The meeting was called to order by Mayor Tipton with Councilwoman Winn leading in prayer. Councilman Waller made a motion to approve the minutes of the September 21, 2006 council meeting. Councilman Ray seconded the motion and it passed with six affirmative votes. A motion was made by Councilman Ray to approve the agenda of the October 5, 2006 council meeting, Councilman Myrick seconded the motion and it passed with six affirmative votes.
Mayor Tipton reported that the City had received notice from EPD of approval of the City's request for an increase in our groundwater withdrawal permit pending receipt of a copy of the contract with the cities of Pooler and Savannah to provide I & D water to areas of Bloomingdale. Bloomingdale is waiting for a copy of the fully executed documents from the City of Pooler.
Council was advised that the City had completed the sales of six surplus items as approved at the September 21st meeting. The Mayor stated that after a review of the bids that had been submitted on the remaining two items, but not accepted due to their being less than the minimum bid, council may want to reconsider the minimum bids of $25 each that was set at the September 21st meeting. Council was informed that bids of $500 or more were submitted on the camper and a bid for $100 was received on the four-wheeler. After a brief discussion, Councilman Ray made a motion to change the minimum bids on these two items and to advertise their sale with minimum bids as follows: 1) '28 Marathon 5th Wheel Camper, Minimum bid $500 & 2) Badger Yamaha 800CM3 4-Wheeler, Minimum bid $100. Councilman Myrick seconded the motion and it passed with six affirmative votes.
The council discussed disposal of two appliances that were replaced during the renovation of City Hall and agreed to advertise for bids on these items at City Hall with minimum bids of $50 each. The items included a Kevinator 16 cu. Ft. Refrigerator and a Tappan 30" Electric Stove. Councilman Ray made a motion to declare these two items as surplus equipment, Councilman Strozier seconded the motion and it passed with six affirmative votes. Councilman Ray made a motion to sell these two items with minimum bids of $50 each with the posting of this information at City Hall. Councilman Myrick seconded the motion and it passed with six affirmative votes.
Mayor Tipton reported that he had talked with Fire Chief Tyler concerning the execution of the documents related to the transfer of properties from the Bloomingdale Volunteer Fire Department to the City of Bloomingdale and was advised that the City can expect to receive this paperwork the first of next week.
The Mayor reported that the City of Bloomingdale received second place in the state in the "Keep Georgia Beautiful" campaign and Mary Mitchell plans to go to Atlanta on October 11th to accept the award on behalf of the City. Mayor Tipton expressed his appreciation to Ms. Mitchell for her hard work on this project. Councilman Rawlings stated that he would also like to recognize the citizens, the members of the Planning & Zoning Commission, and the Bloomingdale Volunteer Fire Department for their part in making the event a success.
1) The Mayor recognized Mark Waller who is requesting a license to operate the "office only" of a home construction business from his residence located at #225 Adams Road. Mr. Waller stated that he and his brother would be working in the business and there would be no outside traffic related to the business coming to his residence. After a brief discussion, Councilman Myrick made a motion to waive the public hearing requirement and issue the home occupation license to Mr. Waller with Councilman Strozier seconding the motion. The motion passed with five affirmative votes. Councilman Waller abstained.
2) Mayor Tipton recognized Charles T. Mock, Jr. who stated that he was requesting a license to operate the "office only" of a pressure washing business from his residence located at #102 Boulevard Street and he would be the only employee. It was noted that the owner of the property, Nathan Nadel, has provided a written statement giving Mr. Mock permission to operate the business from this location. Mr. Mock advised council that there would be no sign posted and no outside traffic related to the business coming to the residence. The council questioned Mr. Mock about the equipment he would be using in the business and was advised that the pressure washing machinery was small and would fit in the back of his pickup truck. Councilman Strozier made a motion to waive the public hearing requirement and issue the home occupation license to Mr. Mock, Councilman Waller seconded the motion and it passed with six affirmative votes.
Council considered a request from Kevin & Kay Heritage for the renewal of the "medical hardship" permit for the secondary mobile home located on their property at #1230 Bloomingdale Road. According to a letter from her physician, Dr. Troy Murphy, the medical condition of Kay's mother, Ho Shim Shaw, still exists and she requires daily assistance from her daughter. Ms. Heritage is requesting a six month extension of the permit which is allowed by the zoning ordinance. Councilman Myrick made a motion to approve the extension as requested, Councilman Strozier seconded the motion and it passed with six affirmative votes.
Mayor Tipton reported that the City has completed preparation of the budget for FY 2006/2007 and a public hearing for citizen input has been scheduled for October 12, 2006 at 7:30pm. The budget will be presented for adoption at the October 19, 2006 council meeting.
Mayor Tipton stated that this concluded the items presented prior to the council agenda deadline of Friday, September 29, 2006.
Councilman Rawlings reported that the Planning & Zoning Commission continues their review of the sign ordinance and expect to make a recommendation to council after their November meeting. Councilman Rawlings stated that the Planning & Licensing Committee will be meeting on October 12, 2006 at 5:30pm to review occupational license fees.
Councilman Myrick advised council that a public meeting has been scheduled for October 12, 2006 at 6:30pm to meet with property owners on Church Street to discuss the proposed paving project.
Being no further business, Councilman Waller made a motion to adjourn at 7:13 p.m. Councilman Strozier seconded the motion and it passed with six affirmative votes.


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The major inspirations for Eternal Desert are: Shadow of the Colossus, Journey, To the Moon and Future Boy Conan (Miyazaki).
game environments are inspired from the most incredible Places of Egypt (and Earth): Abu Simbel, Valley of the Kings, Karnak Temple and Giza Necropolis are only few of the monuments and temples that you will see.
Be ready to experience a Land full of magic and history!


The Combustion flame spraying process, also known as LVOF ( low velocity oxygen and fuel) is the spraying of molten material onto a surface substrate to provide a coating. The spray material, in powder form, is fed continuously into the middle of the flame via an inert carrier gas. The flame consists of oxygen and a fuel gas, either acetylene or hydrogen depending on the melting point of the material to be sprayed, and typically can achieve temperatures in excess of 3000 Celsius. When the spray stream is passed across the surface of the substrate material, the molten material rapidly cools forming a coating.
The combustion spraying process, compared with others, is relativity low energy and can be used to spray substrates that cannot be exposed to high temperatures. This can help when component distortion and structure damage is an issue.
There are two forms of combustion spraying. Either a powder or wire can be used, and both have there advantages. Raw materials are much easier to process into a powder form rather than a wire, and the only limit is the melting point of the powder. However, wire coatings such as molybdenum give excellent bond strength and are often used for bond coats .
Combustion spraying can be used to make repairs, improve efficiency, and restore dimensions. It is often a cost effective method when repairs are required to high cost components. It is most often used for applying coatings that have high oxide and porosity levels, and can be used to achieve rough coatings. They also provide very low stress coatings, therefore allowing very thick coatings to be applied.


You need exposure to high-yield cases to excel in the internal medicine clerkship and on the shelf exam. Case Files: Internal Medicine presents 60 real-life cases that illustrated essential concepts in this area of medicine. Each case includes a complete discussion, clinical pearls, references, definitions of key terms, and USMLE-style review questions. With this system, you'll learn in the context of real patients, rather than merely memorize facts.


Let's find out more about Stepheny.
I was born in Chicago, IL. and raised in Evanston, a suburb north of the city on Lake Michigan.
3) I believe you met a vicar in Jerusalem who inspired your story, tell us more.
The genesis of Greening of a Heart came from a George Herbert poem….
This single line over powered me having watched a vicar find healing on his sabbatical at St. George's College in Jerusalem. I wanted to try and write a story like his. It was the wife of such a man that elbowed her way into my consciousness, however. She demanded I tell her story as well. Thus we have Hannah and Martin Winchester.
4) There are many inspiring gardeners mentioned in your book, who is your favourite and why?
In 2000 I visited some of the most famous gardens in England, staying several nights in Burford at The Bay Tree Inn, and spending time at Rosemary Verey's Barnsley House. As a nod to this famous plants woman, designer, and favourite garden of the trip, I included such experiences in the book. Vita Sackville West, who endlessly fascinates me, prompted a power point lecture I have given to garden club members.
5) Your book had me itching to get out into my own garden, do you have a favourite type of plant?
6) Tell us more about your research?
Henry Bernard took most of a day getting from Kew to Oxford until I found out that such a trip is only 73 miles. Maybe most interesting of all was asking an English friend to read and check for my Americanisms. Closet became cupboard. Driveway became drive. Hannah fixed corn on the cob until I found out there is no corn like that in England. I said pants instead of trousers. A tarp became a tarpaulin. It was great fun making changes like this.
7) I loved the interweaving of characters, which authors have inspired your writing?
I love Rosamunde Pilcher's work and believe it set the stage for one day writing Greening of a Heart. I wish I could take a writing course from Ian McEwen. Jane Gardam has taught me a great deal. Donna Tartt's latest book, The Goldfinch, is like taking a MFA program. I'm addicted to English mysteries. Never without a book in hand, I believe you can't write if you don't read.
8) I know from your blog that you own a beautiful dolls house, I'm glad I read about one in your book, tell us about its history.
My father gave me the dollhouse for my 40th birthday having finished the interior himself. The miniature world is one of my passions. Making and collecting miniatures is an adult hobby I commend to anyone who remains young at heart.
The dollhouse now resides with my oldest granddaughter after a recent move that involved sizing down.
9) You live in the States, what did you learn about writing a book based in a different country?
I put the manuscript down once because I began to doubt that I could do justice to the setting. But internet search engines evolved; I could google the train schedule from Oxford to London, and similar information, that helped authenticate the writing. Anglophile that I am, years of reading, travel to England, and above all garden experience, came together to write about a place I love and characters who's company I miss.
10) Have you thought about a sequel?
Perhaps when I finish a second novel set in Chicago that I am working on.
Thank you Stepheny for a wonderful insight into gardens and your writing. Good luck with the next book.


In Russian the word sukhoi means "dry," but that's not why it is world famous. To be exact, it is the first two letters of this word that have been made into a worldwide brand. SU is not an abbreviation of the Soviet Union, but rather the Sukhoi design bureau – a legendary Russian enterprise, which has been producing military – and now civic – aircraft for more than six decades.
What began as a small design bureau went on to become the Sukhoi Corporation. The Russian government merged Sukhoi with the Mikoyan, Ilyushin, Irkut, Tupolev and Yakovlev design bureaus to form a new company named United Aircraft Building Corporation. Specifically, Mikoyan and Sukhoi were placed within the same operating unit.
But, back in 1939 the young Russian aircraft designer Pavel Sukhoi could hardly have expected that his very own design bureau would become an aviation industry giant. His main factory and design facilities were set up in the city of Kharkov, modern-day Ukraine. Kharkov's pilot and aviation school was considered one of the best in the USSR and the Soviet authorities decided it would be better for the new design bureau to be closer to the training facility.
But Pavel Sukhoi had other plans. He was dissatisfied with his bureau's isolation from the country's scientific spine in Moscow and within a year he managed to earn a re-location for his production line to the Moscow Region.
The first years were rather grim for the Sukhoi bureau. Despite that the country had entered World War II and there was indeed a strong need for good bombers and fighter jets, the SU-6 ground-attack plane, designed by Pavel, was not put into production. It wasn't sanctioned by Joseph Stalin , who favored the Ilyshin IL-2 plane.
In the post-war years, Sukhoi's bureau developed several models of aircraft, including the SU-17 and the SU-24. The last fighter Sukhoi designed was the T-10 - or the SU-27 - but Sukhoi did not live to see it fly. On 25 December 1975, several months after Sukhoi's death, the President of the Academy of Science of the Soviet Union posthumously decorated the designer with the golden medal, in recognition of his significant scientific scholarship.
Indeed, it was this final plane designed personally by Sukhoi , which created a legacy for the Russian military aircraft industry. The SU-27 – also known as the Flanker – made its maiden voyage in 1984, and was quick to impress experts in the Soviet Union. This one-seat jet fighter plane was intended as a direct competitor to the large United States fourth generation fighters like the F-15 Eagle.
The SU-27 could fly within a range of up to 3,500 km without re-fuelling. It carried heavy armament and possessed sophisticated avionics and high agility. From the very beginning the SU-27 was intended for air superiority missions, but was in fact able to perform almost any type of combat operation.
The SU-27's rise to the rank of one of the world's most effective fighter jets came in close competition with another Russian fighter jet – the Mikoyan-Ilyushin-Gurevich design bureau's MiG-29. In fact, their constructive properties are quite similar – especially in aerodynamics. But the SU-27 is substantially larger and heavier than the MiG-29, making it less maneuverable, but at the same time, better protected.
Both models became significant items on the Soviet Union's – and then Russia's - list of war-toys for export. These jets have been bought - and continue to be bought - by dozens of countries from all continents, including China, Ethiopia, Venezuela, the Czech Republic, India and Indonesia.
A total of more than 2000 Sukhoi aircraft have been supplied to foreign countries on export contracts. These birds have been used in just about every military conflict near the end of the 20th century.
On one occasion, the two brands even found themselves on opposite sides of a firefight when the Ethiopian army's SU-27's reportedly gunned down several Eritrean MiG-29's during the military conflict between the two countries.
But the history of Sukhoi aircraft also has a dark page. Despite next to immaculate flight characteristics, the SU jets were involved in several crashes, but – according to official reports – all were caused by human error.
The most dramatic one occurred during an air show in Ukraine's Lviv Region in July 2002 as two inexperienced pilots performed aerobatics in the skies over the Sknyliv airfield. The pilots lost control of the plane during a difficult maneuver and ejected from the jet as it plunged to the ground. However, the plane hit the crowd of spectators, killing 84 people. The two pilots – who survived – were sentenced to 14 and 8 years in prison.
Indeed, it was one of the few incidents of the kind for the legendary brand. And what justifies this status of the SU-27 jet is that it is still being used by the Russian armed forces – 25 years after it took off into the skies for the first time. Over the years, it has undergone different modifications, for example, a two-seater model, the SU-30, was created. But the original design of the Flanker still serves as the basis for all current models.
Today the Sukhoi Corporation has turned its sights on the civic sector as well. The bureau has produced Russia's very first and very own civil aircraft since the collapse of the Soviet Union – the Sukhoi Super Jet 100 – or the SSJ-100.
The 95-seater impressed avionic experts during its presentation at the Moscow Air Show in August 2009 and several deals on the new jet's purchases have already been struck.
Starting from 2010 several airlines – including Russia's Aeroflot – will begin using the SSJ-100, opening a new page in the history of the legendary Sukhoi brand.
Boyar In Medieval Russia, the Boyars represented an aristocratic tier of society as well as a powerful group with the privilege of advising the Tsar on administrative issues. Stalin's Purges Stalin's purges could otherwise be translated as "Stalin's Terror". They grew from his paranoia and his desire to be absolute autocrat, and were enforced via the NKVD (Communist Secret police). Valyat' duraka "Valyat' duraka" is a Russian colloquial idiom meaning "doing nothing", "doing something useless", "goofing off". Samoyedstvo The term Samoyedstvo is Russian jargon for a state people fall into that includes extreme self-criticism, often paired with depression. Zolotaya Rybka The Tale of the Magic Goldfish or The Tale of the Fisherman and the Fish was made famous by the Russian author Alexandr Pushkin in 1833. Khokhloma Wooden kitchenware, colored in a special pattern of red and gold. Nowadays rarely used for it's original purpose, it makes an outstanding souvenir.


Mike Bettison has been a governor at Teesdale School since 2008 taking a particular interest in the arts. He is also a director of the Turrets Youth Theatre, The Village Halls Consortium and a trustee of Bowes Village Hall.
Mike's creative talent is vast and in demand. He is the artistic director of Blaize, a community arts company which has been working in rural areas since 1980.
For the Music@the Heart of Teesdale youth music project he is the lead researcher. This provides material for the youth band 'Cream Tees' as well as for 'Notes from Teesdale' which he performs with Rosie Cross. In general, this targets an elderly audience featuring music, song and stories from the Teesdale area and gathers further information. He has established a digital archive including recordings of local memories.
Mike also runs regular 'Singing for the Brain' sessions for the Alzheimer's Society in Barnard Castle, Middleton-in-Teesdale and Bishop Auckland.


text:
Venezuelan food crisis worsens
An estimated 25,000 Venezuelans trek across the Simon Bolivar International Bridge into Colombia each day for work or to trade goods on the black market.
Increasingly, they are also coming to eat in one of half a dozen facilities offering struggling Venezuelans a free plate of food.
Border cities like Cucuta have become firsthand witnesses to the neighbouring South American nation's escalating humanitarian crisis.
The Colombian government has crafted contingency plans in the event of a sudden, mass exodus.
Church groups and non-profit organisations already are stepping in, moved by images of mothers carrying starving babies and skinny men trying to make a few dollars on Cucuta's streets.
Seeking to highlight the growing plight in Venezuela, United States Vice-President Mike Pence met with people who have fled the country to Colombia.
Pence visited the Calvary Chapel in Cartagena, where he met with faith leaders and Venezuelan families before planning to depart to Buenos Aires, Argentina.
His wife, Karen Pence, helped to lead a prayer circle, where she prayed for "comfort to the Venezuelan refugees".
The vice president and his wife also spent time speaking with the migrants, listening to their emotional stories. Reporters were not able to hear their conversations, but watched the vice president comfort several women, including at least one who was seen wiping away tears.
He said he heard "heartbreaking" stories of their struggle for food.
"President Trump's made it very clear we will not stand by while Venezuela collapses into dictatorship," Pence said, arguing that "a failed state in Venezuela threatens the security and prosperity of our entire hemispheres and the people of the United States".
Pence is trying to rally the region against Venezuelan President Nicolas Maduro's attempts to consolidate power. Pence yesterday denounced Maduro's tactics and said the US will not stand by as Venezuela "crumbles". AP

redpajama_set_name: RedPajamaCommonCrawl


Suitable for Vegetarians and Vegans, Halal and Kosher.
Candelilla wax is derived from the leaves of the Candelilla shrub (Euphorbia cerifera or Euphorbia antisyphilitica), which is native to northern Mexico and the southwestern US. The wax is extracted by boiling the leaves and stems with dilute sulfuric acid and skimming it from the surface of the liquid, prior to further refining.
Candelilla wax is usually hard and brittle with a yellow to brown tinge. It has a typical melting point of 68–73 °C and dissolves in acetone, benzene, chloroform, turpentine and some other organic solvents, but is insoluble in water. Candelilla wax is usually mixed with other waxes to harden them without raising their melting points, or can be used as a substitute for Beeswax or Carnauba wax.
Candelilla wax is a food additive that is used as a protective coating and thickening agent.
Candelilla wax is used as a glazing agent. It also acts as a release agent and a binder for chewing gum.
Candelilla wax is used as a coating for tablets and capsules.
Candelilla wax is used as a component in the manufacture of candles.
Candelilla wax is used in the manufacture of varnish and polish.
Candelilla wax is an ingredient in shoe polish.
In the Personal Care industry, Candelilla wax is used as a component of lip balms and skin moisturising lotions.


For a comfortable and convenient stay near Cedar Point, book your room at the Holiday Inn Express & Suites Sandusky. With amenities including free WiFi access, a fitness center, an indoor pool, and a complimentary breakfast, travelers have everything they need at their fingertips. Guest accommodations feature in-room coffee makers, bath toiletries, and flat-screen TVs, among other amenities.
Stay connected during your visit with complimentary WiFi access.
Fuel up before a day at Cedar Point with a free hot breakfast served daily.
Ample self-parking spaces are available.
The Thirsty Pony restaurant is located next to the hotel.
Located in Sandusky, Holiday Inn Express & Suites Sandusky is minutes from Rain Water Park Complex and close to Pipe Creek Wildlife Area. This hotel is within close proximity of Eleutheros Cooke House and Garden and Firelands Hospital.
Make yourself at home in one of the 73 air-conditioned rooms featuring flat-screen televisions. Complimentary wired and wireless Internet access keeps you connected, and digital programming provides entertainment. Conveniences include phones, as well as desks and complimentary newspapers.
Featured amenities include a business center, a safe deposit box at the front desk, and ATM/banking services. Free self parking is available onsite.
Have you been to Holiday Inn Express & Suites Sandusky? Share your knowledge and be the first to review this.
I can not express how happy I am with the service we got during our stay February 2-4. Working with individuals with special needs your staff made them feel outstanding. Your staff went above and beyond their duties to make them smile and helped them. Great job on the service we experienced during our stay. Definitely bringing them back again. Thank you from the bottom of my heart!!!!!
Stayed here after a long and cold day at cedar point. The beds are comfortable, the room was clean. The pool is small, but nice. The breakfast was great. Would definitely stay here again! Gonna recommend to anyone who needs to stay up here.
Hotel was super clean, staff super friendly, breakfast was to die for! It is also conveniently located. I am a complainer typically but I can not think of a single complaint! Will definletley stay here again!
I could immediately tell this was the newer hotel and the location was great. I was there to meet up with my family to go to the waterpark across the street Saturday evening. Not only was it a really nicely designed hotel but the assistance from the people at the desk for taxi service..was great also. Thanks guys and keep up the good work!
"Great stay after a day at Cedar Point"
We enjoyed our stay at this hotel - good service, friendly staff, clean rooms, and a very good breakfast that is included in the morning. Very close to Cedar Point, so convenient for after you leave the park. We would definitely stay again.
The hotel has 58 non-smoking rooms and 15 suites.
Cribs are offered free of charge on a first come, first served basis upon request. Rollaway beds are available for an additional $10.00 fee per night.
Yes. The hotel has an indoor pool open from 5:30 am to 11:00 pm daily.


Autosomal dominant, ectodermal dysplasia, inherited genetic disease, trichorhinophalangeal syndrome type I, trichorhinophalangeal syndrome type II, trichorhinophalangeal syndrome type III, TRP syndrome, TRP syndrome I, TRPS I, TRPS1.
Trichorhinophalangeal syndrome type I (TRPS I) is a form of ectodermal dysplasia, one of a group of disorders deriving from prenatal abnormalities of the ectodermal structures, such as hair, teeth, nails, and sweat glands.
Trichorhinophalangeal syndrome type I is an extremely rare inherited multisystem disorder characterized by thin, sparse scalp hair, distinctive facial features, abnormalities of the fingers and toes, and skeletal dysplasia (multiple abnormalities of the "growing ends" of the bones). Characteristic facial features may include a rounded pear-shaped nose, an abnormally small jaw, dental anomalies, and unusually large ears. Individuals with TRPS may be slow to develop communication skills. There are three known types (I, II, and III) of trichorhinophalangeal syndrome.
TRPS I is marked by abnormalities of the bones and mild growth retardation. Bone problems may include cone-shaped bones in the fingers and toes, hip problems, and short stature. These features are typically detected later in childhood. Individuals with TRPS I tend to be of average intelligence.
TRPS I is passed down among family members. It is caused by a mutation or defect in the TRPS1 gene. The TRPS1 gene encodes the TRPS I protein and has been identified as a transcription factor, with two alternative transcripts, and is expressed in the fetal brain and kidney, and in the adult heart, brain, placenta, lung, liver, skeletal muscle, and pancreas.
TRPS I is usually inherited as a dominant trait, meaning that only one copy of the defective gene is needed for the condition to appear. However, it has been suggested that TRPS may be an autosomal recessive trait, meaning that two copies of the defective gene must be inherited for the condition to appear.
TRPS I affects males and females equally. Symptoms range from extremely mild to severe, which may make diagnosis difficult. In addition, the actual incidence of the condition is not known because many cases are not diagnosed.
Various treatments exist to address some of the symptoms associated with TRPS I. These may include surgery for the cone-shaped bone ends in the long bones of individuals with TRPS I, proper dental care, nonsteroidal anti-inflammatory drugs (NSAIDs) for relief from pain and inflammation, physical therapy, and speech-language therapy.
General: As in most ectodermal dysplasias, the hair, teeth, and nails are affected in patients with trichorhinophalangeal syndrome type I (TRPS I). In addition, symptoms in patients with TRPS I vary widely, from extremely mild to severe. These symptoms are typically detected later in childhood.
Bones: People with TRPS I tend to have delayed bone age, or a delay in the development of the bones and delayed growth, causing short stature. The epiphyses or "growing ends" of the bones are affected in TRPS I, particularly in the hands and feet. In addition, the fingers and toes tend to be short and curved and the phalanges, the small bones that make up the fingers and toes, may be cone-shaped. Some people who are severely affected by TRPS I may have short forearm bones or flat feet.
Some patients with TRPS I may develop pain and limited range of motion from bone abnormalities, particularly in the hips and hands. Other related conditions may include arthritis in the fingers, elbows, or spine, loss of bone in the thigh, a prominent breastbone, sideways (scoliosis) or backward (lordosis) curvature of the spine, and winglike appearance of the shoulder blades.
Face and head: Patients with TRPS I may have a pear-shaped nose with a bulbous tip and an unusually small jaw. The ears may be large and stick out. The philtrum, the vertical groove in the upper lip beneath the nose, tends to be long and flat with a thin upper lip. There may also be a groove in the chin.
Hair: Hair on the scalp tends to be sparse, thin, and slow growing. It may also be brittle. The hairline may be receding in the front or back of the head. People with TRPS I may lose their hair at a young age, in some people as young as their 20s. Eyebrows also tend to be sparse and may be very thick toward the nose and very thin toward the temples.
Nails: In some cases, patients with TRPS I may have poorly developed or very thin or fragile fingernails and toenails. Nails may grow very slowly and may never require cutting.
Teeth: Patients with TRPS I may have dental problems such as small, discolored, abnormally soft, extra, or missing teeth. They may be especially prone to cavities.
General: Symptoms of trichorhinophalangeal syndrome type I (TRPS I) range from mild to severe, which may make diagnosis difficult. TRPS I may be suspected based on the observation of craniofacial dysmorphism with sparse hair, a pear-shaped nose, an elongated area above the upper lip, and disabling deformities of the hands and feet. The diagnosis is confirmed by the radiologic finding of cone-shaped epiphyses at the base of the middle finger bones. In addition, a detailed family history and complete physical exam should be completed.
Imaging: X-rays may allow a clinician to observe the status of the spine, pelvis, arms, and legs. Skeletal abnormalities that can be diagnosed and tracked using X-rays include arthritis in the fingers, elbows, or spine, loss of bone in the thigh, a prominent breastbone, sideways (scoliosis) or backward (lordosis) curvature of the spine, winglike appearance of the shoulder blades, and cone-shaped epiphyses at the base of the middle finger bones.
Genetic testing: If TRPS I is suspected, DNA sequencing can be used to determine whether the individual has the defective TRPS1 gene. If this mutated gene is detected, a positive diagnosis is made.
Prenatal DNA testing: If there is a family history of TRPS I, prenatal testing may be performed to determine whether the fetus has the disorder. Amniocentesis and chorionic villus sampling (CVS) can diagnose TRPS I. However, because there are serious risks associated with these tests, patients should discuss the potential health benefits and risks with a medical professional.
During chorionic villus sampling (CVS), a small piece of tissue (chorionic villi) is removed from the placenta between the ninth and 14th weeks of pregnancy. CVS may be performed through the cervix or through the abdomen. The cells in the tissue sample are then analyzed for the mutation in the TRPS1 gene. Miscarriage occurs in about 0.5%-1% of women who undergo this procedure.
Arthritis: People with trichorhinophalangeal syndrome type I (TRPS I) may develop arthritis in the fingers, elbows, or spine.
Bone problems: Common bone problems seen in TRPS I include loss of bone in the thigh, a prominent breastbone, sideways (scoliosis) or backwards (lordosis) curvature of the spine, and winglike appearance of the shoulder blades.
Pain: Pain may be caused by arthritis, bone problems, and limited range of motion experienced by some people with TRPS I.
Respiratory infections: Some people with TRPS I may have frequent respiratory infections, which appear to have an unexplained association to TRPS.
Other: Although rare, low blood sugar, diabetes, or low thyroid function may be seen in patients with TRPS I.
There is currently no known cure for trichorhinophalangeal syndrome type I (TRPS I). Instead, treatment aims to reduce symptoms and prevent complications.
Dental care: People with TRPS I should practice good preventive dental care, including brushing their teeth at least twice a day and flossing once a day, seeing a dentist every six months, and avoiding cavity-causing foods and beverages.
Nonsteroidal anti-inflammatory drugs (NSAIDs): Nonsteroidal anti-inflammatory drugs (NSAIDs) have been used to relieve pain and inflammation. Commonly used over-the-counter NSAIDs include ibuprofen (e.g., Advil® or Motrin®) and naproxen sodium (e.g., Aleve®). Higher strength versions of these drugs are also available by prescription. Commonly prescribed NSAIDs include diclofenac (e.g., Cataflam® or Voltaren®), nabumetone (e.g., Relafen®), and ketoprofen (e.g., Orudis®). NSAIDs are often taken by mouth, but they may also be may be injected in very severe cases or applied to the skin. Low doses of NSAIDs are generally taken to manage symptoms.
The U.S. Food and Drug Administration (FDA) requires that all NSAIDs print warning labels that highlight the risk of potential heart-related side effects and stomach bleeding. The labels must also state that patients who have recently had heart surgery should not take NSAIDs. The frequency and severity of side effects vary. The most common side effects include nausea, vomiting, diarrhea, constipation, decreased appetite, rash, dizziness, headache, and drowsiness. The most serious side effects include kidney failure, liver failure, ulcers, heart-related problems, and prolonged bleeding after an injury or surgery. About 15% of patients who receive long-term NSAID treatment develop ulcers in the stomach or duodenum.
Physical therapy: Physical therapy may help some patients with TRPS I improve their mobility. A variety of techniques, including exercises, stretches, traction, electrical stimulation, and massage, are used during physical therapy sessions.
Speech-language therapy: Some patients with TRPS I may benefit from speech-language therapy because these individuals are often slow to develop communication skills. During speech-language therapy, a qualified speech-language professional (SLP) works with the patient on a one-to-one basis, in a small group, or in a classroom, to help the patient improve speech, language, and communication skills. Programs are tailored to the patient's individual needs.
On average, patients receive five or more hours of therapy per week for three months to several years. Doctors typically recommend that treatment be started early to ensure the best possible prognosis for the child.
Surgery: Orthopedic surgery may be performed to treat or correct various skeletal problems that may be present in people with TRPS I, including scoliosis (sideways curvature of the spine) and lordosis (backward curving of the spine).
Note: Currently there is a lack of available scientific evidence on the use of integrative therapies for the treatment or prevention of trichorhinophalangeal syndrome type I (TRPS I). The therapies listed below have been studied for osteoarthritis and related conditions, should be used only under the supervision of a qualified healthcare provider, and should not be used in replacement of other proven therapies or preventive measures.
Chondroitin: Multiple clinical trials have examined the use of oral chondroitin in patients with osteoarthritis of the knee and other locations (spine, hips, and finger joints). Most of these studies have reported significant benefits in terms of symptoms (such as pain), function (such as mobility), and reduced medication requirements (such as anti-inflammatory medications). The weight of scientific evidence points to a beneficial effect when chondroitin is used for six to 24 months Longer-term effects are not clear. Preliminary studies of topical chondroitin have also been conducted.
Chondroitin is frequently used with glucosamine. Glucosamine has independently been demonstrated to benefit patients with osteoarthritis (particularly of the knee). It remains unclear if there is added benefit of using these two agents together compared to using either alone. Chondroitin is currently manufactured from natural sources (shark/beef cartilage or bovine trachea) or by synthetic means. Avoid if allergic or hypersensitive to shellfish or iodine. Some reports suggest a link between glucosamine/chondroitin products and asthma. Use cautiously with diabetes or with a history of bleeding disorders. Avoid if pregnant or breastfeeding.
Glucosamine: Glucosamine is a natural compound that is found in healthy cartilage. Based on human research, there is good evidence to support the use of glucosamine sulfate in the treatment of mild-to-moderate knee osteoarthritis. Most studies have used glucosamine sulfate supplied by one European manufacturer (Rotta Research Laboratorium), and it is not known if glucosamine preparations made by other manufacturers are equally effective. Although some studies of glucosamine have not found benefits, these have either included patients with severe osteoarthritis or used products other than glucosamine sulfate. The evidence for the effect of glycosaminoglycan polysulphate is conflicting and merits further investigation. More well-designed clinical trials are needed to confirm safety and effectiveness, and to test different formulations of glucosamine.
Avoid if allergic/hypersensitive to aspirin, willow bark (Salix spp.), or any of its constituents, including salicylates. Use cautiously with gastrointestinal problems (e.g. ulcers), hepatic disorders, diabetes, gout, hypertension, or hyperlipidemia. Use cautiously with a history of allergy, asthma, or leukemia. Use cautiously if taking medications such as antihyperlipidemia agents, alcohol, leukemia medications, beta-blockers, diuretics, phenytoin (Dilantin®), probenecid, spironolactone, sulfonylureas, valproic acid, or methotrexate. Use cautiously if pre-disposed to headaches. Use cautiously with tannin-containing herbs or supplements. Avoid operating heavy machinery. Avoid in children with chickenpox and other viral infections. Avoid with blood and renal disorders. Avoid if taking other NSAIDs, acetazolamide, or other carbonic anhydrase inhibitors. Avoid with elevated serum cadmium levels. Avoid if pregnant or breastfeeding.
Acupuncture: Acupuncture is commonly used throughout the world. According to Chinese medicine theory, the human body contains a network of energy pathways through which vital energy, called chi, circulates. These pathways contain specific "points" that function like gates, allowing chi to flow through the body. Needles are inserted into these points to regulate the flow of chi. There has been substantial research into the efficacy of acupuncture in the treatment of OA. Most studies focus on knee, cervical, and hip OA symptoms. In recent years, the evidence has improved and is now considered strong enough to recommend trying acupuncture in OA of the knee, which is one of the most common forms of this condition.
Devil's claw: Devil's claw (Harpagophytum procumbens) originates from the Kalahari and Savannah desert regions of South and Southeast Africa. There is increasing scientific evidence suggesting that devil's claw may be safe and beneficial for the short-term treatment of pain related to degenerative joint disease or osteoarthritis (8-12 weeks), and may be equally effective as drug therapies such as non-steroidal anti-inflammatory drugs like ibuprofen (Advil®, Motrin®), or may allow for dose reductions or stopping of these drugs in some patients. However, most studies have been small with flaws in their designs. Additional well-designed trials are necessary.
Fish oil, omega-3 fatty acids: Multiple studies report improvements in morning stiffness and joint tenderness with the regular intake of fish oil supplements for up to three months. Additive benefits have been reported with anti-inflammatory medications, such as nonsteroidal anti-inflammatory drugs (e.g., ibuprofen). However, because of weaknesses in study designs and reporting, better research is necessary before a strong favorable recommendation can be made. Effects beyond three months of treatment have not been well evaluated. Avoid if allergic or hypersensitive to fish, omega-3 fatty acid products that come from fish, nuts, linolenic acid, or omega-3 fatty acid products that come from nuts. Avoid during active bleeding. Use cautiously with bleeding disorders, diabetes, low blood pressure, or if taking drugs, herbs, or supplements that treat any such conditions. Use cautiously before surgery. The Environmental Protection Agency (EPA) recommends that fish intake be limited in pregnant or nursing women to a single six-ounce meal per week and in young children to less than two ounces per week. For farm-raised, imported, or marine fish, the U.S. Food and Drug Administration recommends that pregnant or nursing women and young children avoid eating types with higher levels of methylmercury and less than 12 ounces per week of other fish types. Women who might become pregnant are advised to eat seven ounces or less per week of fish with higher levels of methylmercury or up to 14 ounces per week of fish types with about 0.5 parts per million (such as marlin, orange roughy, red snapper, or fresh tuna).
Physical therapy: The goal of physical therapy is to improve mobility, restore function, reduce pain, and prevent further injuries. Several techniques, including exercises, stretches, traction, electrical stimulation, and massage, are used. Physical therapy for osteoarthritis of the knee may provide short-term benefits, but long-term benefits do not appear better than standard treatments. Physical therapy, either as an individually delivered treatment or in a small group format, appears effective. Limited available human study compared physical therapy to a sham group (sub therapeutic ultrasound) and found that a combination of manual physical therapy and supervised exercise was beneficial for patients with osteoarthritis of the knee.
Not all physical therapy programs are suited for everyone, and patients should discuss their medical history with their qualified healthcare professionals before beginning any treatments. Based on the available literature, physical therapy appears generally safe when practiced by a qualified physical therapist. Physical therapy may aggravate pre-existing conditions. Persistent pain and fractures of unknown origin have been reported. Physical therapy may increase the duration of pain or cause limitation of motion. Pain and anxiety may occur during the rehabilitation of patients with burns. Both morning stiffness and bone erosion have been reported in the literature, although causality is unclear. Erectile dysfunction has also been reported. All therapies during pregnancy and breastfeeding should be discussed with a licensed obstetrician/gynecologist before initiation.
SAMe: S-adenosyl-L-methionine (SAMe) is a naturally occurring molecule that is found in humans. SAMe is present in almost every tissue and fluid in the body, and it has been studied extensively in the treatment of osteoarthritis. SAMe has been shown to reduce the pain associated with osteoarthritis and is well tolerated in this patient population. Although an optimal dose has yet to be determined, SAMe appears as effective as the non-steroidal anti-inflammatory drugs (NSAIDS). Additional study is warranted to confirm these findings.
TENS(transcutaneous electrical nerve stimulation): Transcutaneous electrical nerve stimulation (TENS) is a non-invasive technique in which a low-voltage electrical current is delivered through wires from a small power unit to electrodes located on the skin. Electrodes are temporarily attached with paste in various patterns, depending on the specific condition and treatment goals. Preliminary studies of TENS in osteoarthritis report improvements in joint function and pain. However, most research is not well designed or reported, and better studies are necessary before a clear conclusion can be reached.
Avoid with implantable devices, such as defibrillators, pacemakers, intravenous infusion pumps, or hepatic artery infusion pumps. Use cautiously with decreased sensation (such as neuropathy) or with seizure disorders. Avoid if pregnant or breastfeeding due to a lack of safety evidence.
Ashwagandha: The use of ashwagandha in osteoarthritis has been suggested based on its reported anti-inflammatory and anti-arthritic properties. Well-designed human research is needed to confirm these results.
Supplemental beta-carotene may increase the risk of lung cancer, prostate cancer, intracerebral hemorrhage, and cardiovascular and total mortality in people who smoke cigarettes or who have a history of high-level exposure to asbestos. Beta-carotene from foods does not seem to have this effect. Dizziness, reversible yellowing of palms, hands, or soles of feet and to a lesser extent the face (called carotenoderma) can occur with high doses (50-300 milligrams daily) of beta-carotene. Loose stools, diarrhea, unusual bleeding or bruising, and joint pain have been reported.
Black cohosh: There is not enough human research to make a clear recommendation regarding the use of black cohosh for painful joints in osteoarthritis. Use cautiously if allergic to members of the Ranunculaceaefamily, such as buttercups or crowfoot. Avoid with hormone-mediated conditions, for example, breast, ovarian, or uterine cancer or endometriosis. Avoid if allergic to aspirin products; nonsteriodal anti-inflammatory drugs (NSAIDs), such as Motrin® or ibuprofen; blood thinners, such as warfarin; or with a history of blood clots, stroke, seizures, or liver disease. Stop use before surgery or dental or diagnostic procedures with a bleeding risk and avoid immediately following these procedures. Avoid if pregnant or breastfeeding.
Black currant: The black currant shrub is native to Europe and parts of Asia. Traditionally, black currant fruit has been cultivated mainly for dietary and confectionary purposes. Black currant may help reduce inflammation and morning stiffness associated with arthritis. However, additional research is needed before a firm conclusion can be made. Avoid if allergic or hypersensitive to black currant, its constituents, or plants in the Saxifragaceae family. Avoid with bleeding disorders or if taking blood thinners, unless otherwise recommended by a qualified healthcare provider. Use cautiously with venous disorders or gastrointestinal disorders. Use cautiously if taking antidepressants or vitamin C supplements. Avoid if pregnant or breastfeeding.
Boron: Boron is a trace element, which is found throughout the environment. Based on human population research, individuals who eat foods rich in boron (including green vegetables, fruits, and nuts) appear to have fewer joint disorders. It has also been proposed that boron deficiency may contribute to the development of osteoarthritis. However, it is currently unclear if supplementation with boron is beneficial as prevention against or as a treatment for osteoarthritis.
Boswellia: Resin extracts from the Boswellia serrata tree have been found to have anti-inflammatory effects. Due to boswellia's potential anti-inflammatory properties, boswellia has been suggested as a potential treatment for osteoarthritis. Further research is needed in this area. Boswellia may increase bleeding in sensitive individuals, such as those taking blood thinning medications including warfarin (Coumadin®) and aspirin.
Avoid if allergic to bromelain, pineapple, honeybee, venom, latex, birch pollen, carrots, celery, fennel, cypress pollen, grass pollen, papain, rye flour, wheat flour, or other members of the Bromeliaceaefamily. Use cautiously with a history of bleeding disorders, stomach ulcers, heart disease, liver disease, or kidney disease. Use cautiously before dental or surgical procedures or while driving or operating machinery. Avoid if pregnant or breastfeeding.
Cat's claw: Cat's claw is widely used in the United States and Europe, and it is one of the top herbal remedies sold despite a lack of high-quality human evidence. In Germany and Austria, cat's claw is only available by prescription. Several laboratory and animal studies suggest that cat's claw may reduce inflammation, and this has led to research of cat's claw for inflammatory conditions, such as arthritis. Early research also suggests that cat's claw may reduce pain from knee osteoarthritis. Large, high-quality human studies are needed comparing effects of cat's claw alone vs. placebo before a conclusion can be drawn.
Avoid if allergic to Cat's claw, Uncaria plants, or plants in the Rubiaceae family (such as gardenia, coffee, or quinine). Avoid with a history of conditions affecting the immune system (such as AIDS, HIV, multiple sclerosis, tuberculosis, or lupus). Use cautiously with bleeding disorders or with a history of stroke. Use cautiously if taking drugs that may increase the risk of bleeding. Stop use two weeks before and immediately after surgery/dental/diagnostic procedures with bleeding risk. Avoid if pregnant or breastfeeding. Cat's claw may be contaminated with other Uncaria species. Reports exist of the potentially toxic Texan grown plant, Acacia gregii, being substituted for cat's claw.
Chiropractic: Chiropractic is a healthcare discipline that focuses on the relationship between musculoskeletal structure (primarily the spine) and body function (as coordinated by the nervous system), and how this relationship affects the preservation and restoration of health. Promising results were obtained in the treatment of osteoarthritis using manual physical therapy and exercise. However, presently there is insufficient evidence to support the use of chiropractic manipulation for this condition.
Copper: The use of copper bracelets to treat arthritis has a long history of traditional use, with many anecdotal reports of effectiveness. There are research reports suggesting that copper salicylate may reduce arthritis symptoms more effectively than either copper or aspirin alone. Further study is needed before a recommendation can be made. Avoid if allergic or hypersensitive to copper. Avoid use of copper supplements during the early phase of recovery from diarrhea. Avoid with hypercupremia, occasionally observed in cutaneous leishmaniasis, sickle-cell disease, unipolar depression, breast cancer, epilepsy, measles, Down syndrome, and controlled fibrocalculous pancreatic diabetes, which is a unique form of secondary diabetes mellitus. Avoid with genetic disorders affecting copper metabolism such as Wilson's disease, Indian childhood cirrhosis, or idiopathic copper toxicosis. Avoid with HIV/AIDS. Use cautiously with water containing copper concentrations greater than 6 milligrams per liter. Use cautiously with anemia, arthralgias, and myalgias. Use cautiously if taking oral contraceptives. Use cautiously if at risk for selenium deficiency. The U.S. recommended dietary allowance (RDA) is 1,000 micrograms per day for pregnant women and 1,300 micrograms per day for nursing women.
Dong quai: Dong quai is traditionally used to treat arthritis. However, there is not enough reliable human evidence to recommend the use of dong quai alone or in combination with other herbs. Although dong quai is accepted as a safe food additive in the United States and Europe, its safety in medicinal doses is not known. Reliable long-term studies of side effects are currently unavailable. Avoid if allergic or hypersensitive to Angelica radixor members of the Apiaceae or Umbelliferae family (e.g., anise, caraway, carrot, celery, dill, and parsley). Avoid prolonged exposure to sunlight or ultraviolet light. Use caution with bleeding disorders or with drugs that may increase the risk of bleeding. Use cautiously with diabetes, glucose intolerance or hormone-mediated conditions, such as breast cancer, or uterine or ovarian cancer. Do not use before dental or surgical procedures. Avoid if pregnant or breastfeeding.
Evening primrose oil: Evening primrose oil contains an omega-6 essential fatty acid called gamma-linolenic acid (GLA), which is believed to be the active ingredient. Benefits of evening primrose oil in the treatment of arthritis have not been clearly indicated. More information is needed before a recommendation can be made. Avoid if allergic to plants in the Onagraceae family (e.g., willow's herb and enchanter's nightshade) or gamma-linolenic acid. Avoid with seizure disorders. Use cautiously if taking drugs to treat psychological conditions. Stop use two weeks before surgery with anesthesia. Avoid if pregnant or breastfeeding.
Green tea: Research indicates that green tea may benefit patients with arthritis by reducing inflammation and slowing cartilage breakdown. Further studies are required before a recommendation can be made. Avoid if allergic or hypersensitive to caffeine or tannins. Use cautiously with diabetes or liver disease.
Guided imagery: Guided imagery refers to a number of techniques, including metaphor, storytelling, fantasy, game playing, dream interpretation, drawing, visualization, active imagination, and direct suggestion, using imagery. Therapeutic guided imagery may be used to help patients relax and focus on images associated with personal issues they are confronting. Cognitive-behavioral interventions for pain may be an effective adjunct to standard pharmacologic interventions for pain in patients with osteoarthritis. Further research is needed to confirm these results.
Guided imagery is usually intended to supplement medical care, not to replace it, and guided imagery should not be relied on as the sole therapy for a medical problem. Contact a qualified healthcare provider if mental or physical health is unstable or fragile. Guided imagery techniques should not be used while driving or doing any other activity that requires strict attention. Use cautiously with physical symptoms that can be brought about by stress, anxiety, or emotional upset because imagery may trigger these symptoms.
Magnet therapy: Magnetic fields play an important role in Western medicine. For instance, they are used for magnetic resonance imaging (MRI), pulsed electromagnetic fields, and experimental magnetic stimulatory techniques. Several studies have evaluated the use of magnetic field therapy applied to areas affected by osteoarthritis or degenerative joint disease. In particular, this research has focused on knee osteoarthritis. However, most studies have been small or poorly designed or reported. Efficacy remains unclear. Larger and better quality studies are needed.
Avoid with implantable medical devices, such as heart pacemakers, defibrillators, insulin pumps, or hepatic artery infusion pumps. Avoid with myasthenia gravis or bleeding disorders. Avoid if pregnant or breastfeeding. Magnet therapy is not advised as the sole treatment for potentially serious medical conditions, and should not delay the time to diagnosis a condition. It should also not replace treatment with more proven methods. Patients are advised to discuss magnet therapy with their qualified healthcare providers before starting treatment.
Mistletoe: Once considered a sacred herb in Celtic tradition, mistletoe has been used for centuries for high blood pressure, epilepsy, exhaustion, anxiety, arthritis, vertigo (dizziness), and degenerative inflammation of the joints. According to limited available case study, mistletoe injections may help manage arthritis. Further research is needed before a firm conclusion can be made. Avoid if allergic or hypersensitive to mistletoe or any of its constituents. A life-threatening allergic reaction called anaphylaxis has been described after injections of mistletoe. Avoid with acute highly febrile inflammatory disease, thyroid disorders, seizure disorders, or heart disease. Use cautiously with diabetes, glaucoma, or if taking cholinergics.
Niacin: Vitamin B3 consists of niacin (nicotinic acid) and its amide, niacinamide, and can be found in many foods, including yeast, meat, fish, milk, eggs, green vegetables, and cereal grains. Preliminary human studies suggest that niacinamide may be useful in the treatment of osteoarthritis. Further research is needed.
Pantothenic acid (vitamin B5): Pantothenic acid is found in many foods, including, meats, liver, kidney, fish/shellfish, chicken, vegetables, legumes, yeast, eggs, and milk. Pantothenic acid has been suggested as a possible treatment for osteoarthritis. However, further research is needed to determine whether or not this treatment is effective.
Avoid if allergic or hypersensitive to pantothenic acid or dexpanthenol. Avoid with gastrointestinal blockage. Pantothenic acid is generally considered safe in pregnant and breastfeeding women.
Relaxation therapy: Relaxation techniques include behavioral therapeutic approaches that differ widely in philosophy, methodology, and practice. The primary goal is usually non-directed relaxation. In a randomized study of patients with osteoarthritis pain, Jacobson relaxation was reported to lower the level of subjective pain over time. The study concluded that relaxation may be effective in reducing the amount of analgesic medication taken by participants. Further well-designed research is needed to confirm these results.
Avoid with psychiatric disorders, such as schizophrenia or psychosis. Jacobson relaxation, which involves flexing and relaxing specific muscles, should be used cautiously with illnesses such as heart disease, high blood pressure, or musculoskeletal injury. Relaxation therapy is not recommended as the sole treatment approach for potentially serious medical conditions, and it should not delay the time to diagnosis or treatment with more proven techniques.
Stinging nettle: Stinging nettle is found in Africa, Europe, and North America. This perennial plant has been used as medicinally since ancient times. Nettle is widely used as a folk remedy to treat arthritic and rheumatic conditions throughout Europe and in Australia. Preliminary evidence suggests that certain constituents in the nettle plant have anti-inflammatory or immunomodulatory activity. More study is needed to confirm these findings. Avoid if allergic or hypersensitive to nettle, the Urticaceae family, or any ingredient of nettle products. Use cautiously with diabetes, bleeding disorders, or low blood sodium levels. Use cautiously with diuretics and anti-inflammatory drugs. The elderly should also use nettle cautiously. Avoid if pregnant or breastfeeding.
Tai chi: Tai chi is a system of movements and positions believed to have been developed in 12th Century China. Tai chi techniques aim to address the body and mind as an interconnected system, and are traditionally believed to have mental and physical health benefits to improve posture, balance, flexibility, and strength. A small trial in women with osteoarthritis reported that treatment with tai chi significantly decreased pain and stiffness compared with a sedentary lifestyle. Women in the tai chi group also reported fewer perceptions of difficulties in physical functioning.
Turmeric: The rhizome (root) of turmeric (Curcuma longa Linn.) has long been used in traditional Asian medicine. Turmeric has been used historically to treat rheumatic conditions. Laboratory and animal studies show anti-inflammatory activity of turmeric and its constituent curcumin, which may be beneficial in people with osteoarthritis. Reliable human research is lacking. Turmeric may increase bleeding in sensitive individuals, such as those taking blood thinning medications including warfarin (Coumadin®) and aspirin. Further research is necessary.
Yoga: Yoga is an ancient system of relaxation, exercise, and healing with origins in Indian philosophy. Yoga is often practiced by healthy individuals with the aim to achieve relaxation, fitness, and a healthy lifestyle. Based on a pilot study, yoga may help reduce pain and disability caused by knee osteoarthritis (OA) in some patients. Further research is needed.
General: Because trichorhinophalangeal syndrome type I (TRPS I) is an inherited condition, there is currently no known way to prevent the disease. However, a number of options are available for prospective parents with family histories of TRPS I.
Genetic testing and counseling: Individuals who have TRPS I may meet with a genetic counselor to discuss the risks of having children with the disease. Individuals with family histories of TRPS I may meet with a genetic counselor to determine whether they carry the defective TRPS1 gene. Carriers can be determined through detailed family histories or genetic testing.
Known carriers of TRPS I may undergo genetic counseling before they conceive a child. Genetic counselors can explain the options and the associated risks of various tests, including pre-implantation genetic diagnosis (PGD), amniocentesis, and chorionic villus sampling (CVS).
Pre-implantation genetic diagnosis (PGD) may be used with in vitro (artificial) fertilization. In PGD, embryos are tested for the defective TRPS1 gene, and only the embryos that are not affected may be selected for implantation. Because TRPS I can be detected in a fetus, parents may choose whether to continue the pregnancy. Genetic counselors may assist parents with these difficult decisions.
Böni R, Böni R, Tsambaos D, et al. Trichorhinophalangeal syndrome. Dermatology. 1995;190:152-5.
Carrington PR, Chen H, Altick JA. Trichorhinophalangeal syndrome, type I. J Am Acad Dermatol. 1994; 31: 331-6.
Dunbar JJ, Sussman MD, Aiona MD, et al. Hip pathology in the trichorhinophalangeal syndrome. J Pediatr Orthop. 1995;15:381-5.
Felman AH, Frias JL. Trichorhinophalangeal syndrome--study of 16 patients in one family. Am J Roentgen. 1977;129:631-8.
Giedion A. Phalangeal cone-shaped epiphyses of the hand: their natural history, diagnostic sensitivity, and specificity in cartilage hair hypoplasia and the trichorhinophalangeal syndromes I and II. Pediatr Radiol. 1998;28:751-8.
Goodman RM, Trilling R, Hertz M, et al. New clinical observations in the trichorhinophalangeal syndrome. J Craniofac Genet Dev Biol. 1981;1:15-29.
Ludecke H-J, Schaper J, Meinecke P, et al. Genotypic and phenotypic spectrum in tricho-rhino-phalangeal syndrome types I and III. Am J Hum Genet. 2001;68:81-91.
Naselli A, Vignolo M, Di Battista E, et al. Trichorhinophalangeal syndrome type I in monozygotic twins discordant for hip pathology: report on the morphological evolution of cone-shaped epiphyses and the unusual pattern of skeletal maturation. Pediatr Radiol. 1998;28:851-5.
Parkhurst RD, Light GS, Bacon GE, et al. Tricho-rhino-phalangeal syndrome with hypoglycemia: case report with endocrine function studies. South Med J. 1972;65:457-9.
Rodriguez-Serna M, Serrano G, Perez A, et al. What syndrome is it? Trichorhinophalangeal syndrome. Pediatr Dermatol. 1993;10:385-7.
Autosomal dominant inheritance: Trichorhinophalangeal syndrome type I (TRPS I) is caused by a mutation or defect in the TRPS1 gene. The TRPS1 gene encodes the TRPS I protein and has been identified as a transcription factor with two alternative transcripts, and is expressed in the fetal brain and kidney, and in the adult heart, brain, placenta, lung, liver, skeletal muscle, and pancreas. TRPS I is inherited, or passed down among family members, as a dominant autosomal trait. Individuals receive two copies of most genes, one from the mother and one from the father. For a dominant disorder to appear, only one defective copy of the TRPS1 gene is necessary. If one parent has the disorder, there is a 50% chance that his or her child will have the disorder. If both parents have the disorder, there is a 75% chance that their child will have the disorder.
Autosomal recessive inheritance: Rarely, TRPS I occurs as an autosomal recessive trait. Therefore, a person must inherit two copies of the defective gene, one from each parent. Individuals who inherit only one copy of the defective TRPS1 gene generally have no symptoms and are called carriers because they can pass on the disorder to their children.
If one parent is a carrier, or has only one copy of the defective gene, then each child has a 50% chance of inheriting one defective gene and of also being a carrier. If both parents are carriers, each child has a 25% chance of inheriting two defective genes, a 50% chance of inheriting one defective gene, and a 25% chance of inheriting neither defective gene. Therefore, if both parents are carriers, about one out of four children will have TRPS I.
Sometimes, a person with only one copy of the recessive defective TRPS1 gene will still develop the disorder. This is because the normal copy of the gene cannot compensate for the defective gene, a condition known as haploinsufficiency.
Random occurrence: It is currently unknown whether TRPS I can occur as the result of a spontaneous genetic mutation with no family history of the disease.
Currently, the only known risk factor for trichorhinophalangeal syndrome type I (TRPS I) is a family history of the disease. Trichorhinophalangeal syndrome type I (TRPS I) is caused by a mutation or defect in the TRPS1 gene. TRPS I is usually inherited, or passed down among family members, as a dominant trait, although it has been proposed that TRPS I may be inherited as an autosomal recessive trait.
There are three types (I, II, and III) of trichorhinophalangeal syndrome.
Trichorhinophalangeal syndrome type II is characterized by a bulbous, pear-shaped nose, elongated upper lip, sparse hair, cone-shaped bone ends, and mild growth retardation, as is observed in TRPS I and III. However, TRPS II can be distinguished from TRPS I by the presence of extra skin. While TRPS I is inherited in an autosomal dominant fashion, most cases of TRPS II occur spontaneously, although there are a few cases that are inherited.
Trichorhinophalangeal syndrome type III shares many common features with TRPS I. However, unlike TRPS I, TRPS III is associated with extremely short fingers and short stature. The mechanisms underlying the genetic transmission of TRPS III have not been determined.


text:
Tejamaniles är en ort i Mexiko.   Den ligger i kommunen Ahuazotepec och delstaten Puebla, i den sydöstra delen av landet,  km nordost om huvudstaden Mexico City. Tejamaniles ligger  meter över havet och antalet invånare är .

Terrängen runt Tejamaniles är huvudsakligen kuperad, men den allra närmaste omgivningen är platt. Den högsta punkten i närheten är Cerro La Bandera,  meter över havet,  km öster om Tejamaniles. Runt Tejamaniles är det ganska tätbefolkat, med  invånare per kvadratkilometer. Närmaste större samhälle är Huauchinango,  km nordost om Tejamaniles. I omgivningarna runt Tejamaniles växer i huvudsak blandskog.

Ett tropiskt höglandsklimat råder i trakten. Årsmedeltemperaturen i trakten är  °C. Den varmaste månaden är april, då medeltemperaturen är  °C, och den kallaste är september, med  °C. Genomsnittlig årsnederbörd är  millimeter. Den regnigaste månaden är augusti, med i genomsnitt  mm nederbörd, och den torraste är januari, med  mm nederbörd.

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Goldman Sachs Trades Tokenized Treasury Bonds On JPMorgan's Private Blockchain Network For The First Time
© Provided by Benzinga
Goldman Sachs Group Inc (NYSE: GS) has made its first trade on JPMorgan Chase & Co. (NYSE: JPM) private blockchain network.
What Happened: A report from Bloomberg revealed that the repo trade was conducted on June 17, and the transaction was completed after three hours and five minutes. However, the value of the transaction remains unknown.
Goldman Sachs successfully swapped a tokenized version of a U.S. Treasury bond for JPM Coin – JPMorgan's stablecoin, which is pegged 1:1 to the value of the U.S. dollar.
Why It Matters: "We see this as a pivotal moment for the digitization of transactional activity," said Mathew McDermott, global head of digital assets for Goldman's global markets division.
McDermott believes that the utilization of blockchain technology in the repo market is "a pivotal moment for the digitization of transactional activity," as, unlike the traditional repo market, the exact timing of each transaction can now be logged.
"We pay interest per the minute. We firmly think this will change the nature of the intraday marketplace," he said.
Read also: Goldman Sachs Makes Move Into Blockchain With Latest Investment In Crypto Staking Platform Blockdaemon
Smart contracts on the blockchain enable the cash and collateral to interchange simultaneously, and McDermott noted that this is a big step up for the repo market which is valued at $4.6 trillion.
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text:
Penalty for Taking Advantage of Power of Attorney
By: Mike Broemmel
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Image by Flickr.com, courtesy of D. Sharon Pruitt
If you are appointed the agent of a power of attorney, you assume what are known as fiduciary duties. That means you are required to act in an honest manner while dealing with the affairs and assets of the person who granted you power of attorney.
The primary function of an agent through a power of attorney is to protect the financial or health interests of the person who created the instrument.
Your duty as an agent can be breached in a number of ways, such as failing to act on behalf of the granter or misappropriating funds belonging to the granter.
Civil Penalty
A civil lawsuit is one possible penalty for taking advantage of power of attorney. The granter can sue you for breaching your duty.
Criminal Penalty
In some instances taking advantage of power of attorney can lead to a criminal charge, most commonly theft or fraud.
Always deal in the best interests of the granter. Even the appearance of impropriety can cause problems for you.
Legal Services for the Elderly: Power of Attorney
"A Practitioner's Guide to Powers of Attorney;" John Thurston; 2007
Kansas Bar Association: Durable Power of Attorney for Health Care


Dr Paolo Vargiu is a Lecturer in Law at the School of Law of the University of Leicester. He holds a JD from the University of Cagliari (Italy), an LLM and a PhD from the University of Nottingham; he is also a Fellow of the Higher Education Academy and a practicing member of the Italian Bar. In 2016, Paolo Vargiu will undertake a Visiting Fellowship at the Institute of Advanced Legal Studies (IALS), London. He has published in the fields of international investment law, public international law and human rights, and is the author of Investment Blawg, a weblog on investment law and arbitration. He coaches the University of Leicester Vis Moot Team, and he regularly participates to the Annual Willem C. Vis International Commercial Arbitration Moot as arbitrator.


Is there something without which you think you cannot serve or worship God? If not careful, we expect certain music, rituals, or even technology to produce a spiritual "atmosphere." The truth is that neither a killer praise band nor liturgy and lighting candles can guarantee worship. Hebrews 10:1 says, "Since the law was only a shadow of good things to come, and not the actual form of those realities, it can never perfect the worshipers by the same sacrifices they continually offer year after year." We sometimes accept cheap substitutes of the real thing.
The problem is that all too often we spend more time focusing on our delivery method than we do depending on our Deliverer! Once again, let me caution you about saying "amen" because you have interpreted me to be talking about those other guys that do not do it like we do. What are some guiding principles on which we can build our ministry that can help to keep us focused on the right things? Why would we settle for cheap substitutes, the bells and whistles, when the real substance, Jesus Christ, is available to all who follow Him?
First, everything must be about exalting the name of Jesus! We know that God resists the proud and gives grace to the humble. He says in Isaiah 42:8, "I am Yahweh, that is My name; I will not give My glory to another or My praise to idols." When we do anything to bring attention to ourselves we are in danger of Him not showing up in a powerful way. He inhabits the praise of His people, which is directed at Him so that He receives the honor and the glory.
Second, we need to make sure we are known as a house of prayer! How much time do we actually spend praying as a body of believers? Our job is to get into His presence so that we can hear from Him. God's job is to move in our presence as He empowers and directs us. The wonderful thing is that when we do our job He always does His. When we pray for Him to move in our midst we know that we are praying what is His will.
Third, allow Him to fill is with His fullness. Ephesians 4:10 says, "The one who descended is also the one who ascended far above all the heavens, that He might fill all things." We fill our life with so many things, but are we allowing Him to fill us with His fullness? We see in Ephesians that we are to be filled with the fullness of the Father (3:19), filled with Christ's fullness (4:13), and filled with the fullness of the Holy Spirit. The Father planned our salvation, the Son provided our salvation, and the Holy Spirit applies our salvation.
Fourth, make sure you strive for excellence. The key to keeping our eyes on the author and finisher of our salvation is to fill our hearts with the right things. God gives us enabling grace but we are also responsible to believe, trust, obey, and follow Him. Colossians 3:23 says, "Whatever you do, do it enthusiastically, as something done for the Lord and not for men." A great way of looking at excellence is to do the best with what you have.
Fifth, be thankful for what you have and what God has given you. Enabling grace from God plus enacting faith leads to us fulfilling His intended purpose. God is in charge of the gifts He gives each of us. We should not seek any particular gifts but trust how He has distributed them. The gifts He gives come from Him so therefore they need to be used and not buried. Also, no gift should be exalted above any other gift and we should humbly serve others with our gifts.
Sixth, do what you do for Christ with excellence but also do it where it can strategically help carry out the mission of God. We do not need all the bells and whistles if we are doing it for the glory of God. You also will then do your work out of your heart for the benefit of others. Then you will be able to leverage appropriate opportunities to share the love of God with others. All the tools are great but nothing can replace love, kindness, friendship, and genuine care.
Seventh, remember to make the most of the place where God has planted you. Jim Elliot said, "Wherever you are, be all there! Live to the hilt every situation you believe to be the will of God." God has a purpose for you. Your testimony and influence grows out of how you carry out your calling with passion. Colossians 2:17 states, "These are the shadow of what was to come; the substance is the Messiah." The bells and whistles are all the trimmings but the real substance is in knowing Him!


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bioaccumulation in aquatic species: fish
19-5-2000 - 23-11-2000
OECD Guideline 305 (Bioconcentration: Flow-through Fish Test)
yes (incl. certificate)
- Sampling intervals/frequency for test organisms: after 1, 2, 6, 7, and 8 days of exposure and each day during elimination
- Sampling intervals/frequency for test medium samples: daily during exposure starting 2 days prior to exposure
- Sample storage conditions before analysis: Not relevant, samples were analysed immediately
- Details on sampling and analysis of test organisms and test media samples (e.g. sample preparation, analytical methods): The water samples (2 mL) were measured on the dayof the sampling. The fish sampled were rinsed quickly with untreated water, blotted dry and then instantly killed. Subsequently, fish were weighed. The fish were pooled in two samples of two fish. A homogenate was prepared of each of the pooled samples by dissolving the samples in Soluene 350. After the samples had been completely dissolved, a part of the homogenate was weighed and used to determine the bioconcentration in the wholefish. Then 100 mL of H2O2 (35%) was added to each sample to bleach them during a period of at least 2 hours before the scintillation liquid was added.
Details on preparation of test solutions, spiked fish food or sediment:
PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: The stock solutions were individually prepared in a mixture of ethanol at a factor 10000 higher than the final test concentration. Both stock solutions contained 7 mg/L 14C-Iabelled 2-Ethylhexyl 4-methoxycinnamate.
- Controls: Test medium without test substance but with ethanol at 100 mg/L.
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): ethanol
- Concentration of vehicle in test medium (stock solution and final test solution(s) at different concentrations and in control(s)): 0.1 mL/L
- Evidence of undissolved material: no
Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Common name: Rainbow trout
- Source: Blo International, Horn, The Netherlands
- Length at study initiation (lenght definition, mean, range and SD): 4.9 ± 0.14 cm (n = 60)
- Weight at study initiation (mean and range, SD): 1.94 ± 0.21 g (n = 60)
- Weight at termination (mean and range, SD): no data, the possible increase of weight is considered irrelevant (short study period)
- Health status: Healthy fish supplied with a health certificate
- Feeding during test
- Food type: Trouvit.
- Amount: Ca. i % of bodyweight per day of Feeding rate was recalculated after every time fish had been sampled during the uptake phase.
- Frequency: daily
ACCLIMATION
- Acclimation period: At least 12 days after delivery. The fish were allowed to acclimatize to the test conditions without test substance for seven days prior to testing.
- Acclimation conditions (same as test or not): yes
- Type and amount of food: Trouvit
- Feeding frequency: Daily
Route of exposure:
Water / sediment media type:
natural water: freshwater
Total exposure / uptake duration:
Total depuration duration:
200 - 220 mg CaCO3/L
control 15.5 ± 0.7, low exposure 15.2 ± 0.7, high exposure 15.3 ± 0.7
group Day of measurement
Respectively at day 0, 2, 5, 12 and 14: Control 9.1 6.9 6.4-9.0 8.8 8.2
Lowerlevel 9.0 6.8 6.6-9.0 8.9 8.4
Higher level 9.1 6.8 6.7-9.0 9.1 8.6
In none of the samples taken from the dilution water, the total concentration of organic carbon exceeded
10mg/I.
Salinity:
- Test vessel: 100 litres (50x50x40 cm) consisting of stainless steel and covered by a removable Perspex plate.
- Type: closed
- Aeration: no
- Type of flow-through (e.g. peristaltic or proportional diluter): via a computer-controlled system consisting of micro-dispensers
- Renewal rate of test solution (frequency/flow rate): 12 L/h
- No. of organisms per vessel: 40
- No. of vessels per control / vehicle control (replicates): 1
- Biomass loading rate: 0.3 g fish.litre-1.day-1.
- Source/preparation of dilution water: tap water
- Intervals of water quality measurement: pH, nitrate and nitrite concentration and ammonia concentration: once a week. Temperature: every day
- Photoperiod:16 hours photoperiod daily
RANGE-FINDING / PRELIMINARY STUDY
- Test concentrations:
- Results used to determine the conditions for the definitive study:
- Conductance: 15 °DH, corresponds with 260 - 270 mg CaCO3/L.
- Intervals of water quality measurement: Dissolved oxygen content and pH: two times during the five-day uptake period, at the start and once a week during the depuration period; temperature: daily; Total hardness and conductivity: At the start and the end of the test period
- Photoperiod: 16 hours photoperiod daily
nominal: 0, 70 and 700 µg/L
71.8 - 89.3 µg/L (time weighed average 84 ± 6.7 µg/L), 731, 789 µg/L (time weighed average 731 ± 22 µg/L)
Details on estimation of bioconcentration:
not relevant, bioconcentration is measured
not measured/tested
Conc. / dose:
ca. 70 µg/L
433 L/kg
whole body w.w.
Time of plateau:
Calculation basis:
steady state
other: Upper limit, range 279 - 433
ca. 700 µg/L
other: upper limit, range 64 - 175
Elimination:
Depuration time (DT):
Details on kinetic parameters:
- Uptake rate constant (k1): no
- Depuration (loss) rate constant (k2): -0.4184 for the low concentration and -0.4572 for the high concentration.
- Indication of bi- or multiphasic kinetics: yes
Metabolites:
- Behavioural abnormalities: no
- Observations on body length and weight: considered not significant
- Mortality and/or behavioural abnormalities of control: no
- Results with vehicle control: no abnormalities
During the first 1.24 days, the concentration of Ethylhexyl Methoxycinnamate in the fish exposed to 70 µg/L increased to 32 µg/g fish, while the concentration in the fish exposed to 700 µg/L increased to 49 µg/g. The concentration in the fish exposed to 70 µg/L varied between 25 and 36 µg/g during the remaining period of the uptake phase.
The BCF remained rather constant between 279 and 433 with an average of 373. Until day 5, the concentration in the fish exposed to 700 µg/L only slowly increased after the first day until 2.25 days. The BCF remained constant at 64 - 72. However, on the last day the concentration in the fish had increased by more than a factor of two resulting in a final BCF of 175.
At the lower exposure level the BCF was 433 and at the higher level the BCF was 175. Depuration (DT50) of Ethylhexyl Methoxycinnamate out of the fish was 1.5 to 1.7 days.
A l4 days Bioconcentration test in rainbow trout with 2-Ethylhexyl 4-methoxycinnamate and radiolabelled Ethylhexyl Methoxycinnamate was conducted according to the OECD guidelines for Testing of Chemicals, guideline No. 305: Bioconcentration: Flow-through Fish Test. During the first 1.24 days, the concentration of Ethylhexyl Methoxycinnamate in the fish exposed to the lower level of Ethylhexyl Methoxycinnamate increased to 32 µg/g fish, while the concentration in the fish exposed to the higher level increased to 49 µg/g. At the lower level the BCF remained rather constant between 279 and 433 with an average of 373. At the higher level, the concentration in the fish only slowly increased after the first day until 2.25 days and the BCF remained below 100 (64 - 76). However, on the last day the concentration in the fish had increased by more than a factor of two resulting in a final BCF of 175. Depuration of Ethylhexyl Methoxycinnamate out of the fish was exponential with a DT50 of 1.5 to 1.7 days and a DT 90 of 5.0 to 5.5 days.
Bioconcentration factor: 279 - 433 at test concentration 70 µg/L, 64 - 175 at test concentration 700 µg/L (OECD TG 305)
BCF (aquatic species):
433 L/kg ww
The 14-day Bioconcentration test in rainbow trout was performed with radiolabelled Ethylhexyl Methoxycinnamate. During the first day, the concentration in the fish exposed to the lowest level (70 µg/L) increased to 32 µg/g fish, while the concentration in the fish exposed to the higher level (700 µg/L) increased to 49 µg/g. At the lower level the BCF remained rather constant between 279 and 433 with an average of 373. At the higher level, the concentration in the fish only slowly increased until day 2 and the BCF remained below 100 (64 - 76). However, on the last day the concentration in the fish had increased by more than a factor of two resulting in a final BCF of 175. Depuration of Ethylhexyl Methoxycinnamate out of the fish was exponential with a DT50 of 1.5 to 1.7 days and a DT90 of 5.0 to 5.5 days.


text:
What is the Family Justice Center?
The Family Justice Center of Ouachita Parish (FJC) is a one-stop information and service center here to serve those seeking assistance in domestic violence or teen dating situations, for sexual assault or stalking. We have worked throughout Northeast Louisiana to form collaborative partnerships to end Domestic Violence, Sexual Assault, Teen Dating Violence and Stalking. The office is located at 620 Riverside Drive in Monroe, LA.
The FJC's goal is to make services more accessible to victims of these crimes by locating together:
• Social Workers- housing, food, childcare & job search assistance
• Clergy
• Counselors
• Medical personnel
• Civil legal assistance
{protection orders, divorce, child custody/support, etc.}
• Law enforcement
• Prosecutors
• Community volunteers
To provide a safe and accessible, central intake and service center for survivors of domestic violence, sexual assault, dating violence and stalking to receive comprehensive, coordinated community services.
Services available at the FJC:
• Safety Planning
• Domestic Violence Education
• Assistance with obtaining protective orders
• Counseling for survivors of domestic violence & sexual assault
{and for children who have witnessed domestic violence}
• Referral to safe, confidential emergency shelters or housing
• Referral to legal assistance
• Assistance with medical care and prescriptions
• Child care and transportation while receiving services at FJC
• Dating Violence Education
• Food vouchers
• Chaplain services
• Translation services
• Financial empowerment
• Law enforcement reports
• Interviews with Assistant District Attorney
• Financial Assistance
Individuals seeking assistance at the FJC may choose to use any/all of these services (subject to availability). All services are free and confidential.
Domestic violence in Northeast Louisiana is a community concern that is a blow to us all. In 1988, the SAFE (Stopping Abusive Family Environments) Task Force was formed by agencies in Ouachita Parish. In 2005, those agencies formed the Family Justice Center of Ouachita, making the parish a safer place.
The Family Justice Center of Ouachita was one of the first 15 centers in the nation to receive a grant under President Bush's initiative, as well as the first to operate in the state of Louisiana.
The FJC uses co-location, a national best practice that puts agencies that serve victims under one roof, making it easier for those who need services to get them while batterers are held accountable for their actions. Since the center opened in 2005, rates of reports of domestic and dating violence have fallen by 47.6% (2,873 in 2004 vs 1,505 in 2012). Further, far more victims receive services, as shown by the 20.6% increase in persons served (557 in 2012 vs. 462 in 2006) since the first full year the FJC was operational.
We are proud to be one of the first 15 Family Justice Center's in the country. The Family Justice Center of Ouachita Parish was established in October of 2005 as part of a Presidential Initiative by President George W. Bush.


There are various ways of making French toast. You have those that use any bread they have on hand, those that use King's Hawaiian sweet bread, and others only use Challah bread. My mom actually uses a French baguette to make smaller French toasts which don't even require a fork for eating them. And I have my own way.
I like to use cinnamon bread. Cinnamon always makes everything better and the bread is denser than a usual loaf of sandwich bread, which is perfect for French toast.
I also like to slice the bread into "sticks" and stack them up, like Jenga. Who says you can't have fun while cooking..or eating? French toast sticks are way more fun!
Dash, our kitten, couldn't wait to get his paws on these!
These French toast sticks are delicious and fun to eat!
Whisk together egg, milk, and stevia.
Slice each bread slice into 4 "sticks" (8 total).
Spray skillet with cooking spray.
Dip each bread slice into egg mixture (cover all sides) and place in skillet.
Sprinkle the uncooked side with cinnamon and let it cook for about 1-2 minutes on each side. Check for doneness periodically. A side is cooked through when the bread is browning.
Top French toast sticks with whipped cream cheese and maple syrup (my favorite combo) or your favorite toppings (if you need any).
These look absolutely divine, We made the french toast sticks two nights ago and they were delicious.


By Greg O'BrienCodfish Press There was a popular bumper sticker circulating San Francisco in the late 1960s, heralding the end times that proclaimed: ?Jesus is coming and man, is He pissed!? Like pop culture, the bumper sticker quickly spread East. I got in trouble in high school for pasting it on the rear of my Buick. The Jesuits didn?t think it was funny. Funny or not, the bumper sticker has many people thinking again, given the wild happenings in the world today: the constant threat of terrorism; the Asian tsunami that killed more than 120,000; Katrina floods of Noah proportions; mudslides in Central America that have created mass gravesites; a crushing Pakistan quake whose death toll is pushing 40,000; the melting of polar ice caps that indicate, several climatologists say, a global warming trend that could in time cause devastating flooding and fuel more intense hurricanes; a feared avian flu pandemic that experts warn could inflict a 50 percent fatality rate worldwide. ?We and the entire world remain unprepared for what could arguably be the most horrific disaster in modern history,? Gregory Poland, an immunization specialist at the Mayo Clinic, said of the avian flu threat in a Hearst Newspaper report. ?What we are talking about is not just another health issue?it is a nation-busting event,? added Tara O?Toole of the University of Pittsburgh Medical Center.Is anyone listening? Are these signs of the apocalypse detailed in the Book of Daniel, the Gospel of Matthew and the Book of Revelation, or are we just having a global stretch of bad luck? A quick read of Matthew 24: 6-8 is as sobering as the demise of Lot?s wife: ?You will hear of wars and rumors of wars, but see to it that you are not alarmed. Such things must happen, but the end is still to come. Nation will rise against nation, and kingdom against kingdom. There will be famines and earthquakes in various places. All these are the beginning of birth pains.? Many expect the labor to last for generations, but are covering all bets. ?I prefer the bumper sticker that says: Jesus is coming, look busy!? says the Rev. Paul Ring, parochial vicar of St. Marks parish in Dorchester where the late Rose Kennedy worshipped along with her father ?Honey Fitz,? then the mayor of Boston. So is God hurling thunderbolts??No, but I think it?s a wake-up call,? Father Ring said in an interview. ?Scripture tells us no one will know the time of the end, but what I think we?re experiencing today is the permissive will of God: not that the Almighty causes bad things to happen, but that God allows them to stir.? Father Ring advises those watching ?to take a deep breath and use this as an opportunity to grow in grace.? The Rev. David Otis, pastor of Protestant-oriented First Light Church of Cape Cod in Chatham, and a former reporter for the San Bernardino Sun and a former contributor to Time Magazine and the L.A. Times, agrees. ?If you start putting pins on a world map, it gets your attention. I think God is taking hands off the world because of our collective choices?and the direction of our lives?the common grace that has protected this planet is being slowly removed. I think this a time for all of us to evaluate where we stand. And for most of us, that?s not on firm spiritual ground.?No need to get sensational about it. What?s happening in the world is sensational enough.?It?s late in the fourth quarter, preaches Otis, and a time for some hard-knuckle defense. ?We ought to punt, and give it over the Lord. The clock is ticking down.? Thanks for the word picture, reverend, and the sports clich?s. See you in church soon. I?ll be the one in the back pew, near the confessional line, getting ready to snap the ball.


text:
Q: Oracle SOA-BPEL accessing nested XML elements for variable assignment I have a use case related to XPath query issue regarding nested XML data access. Kindly check the below screenshot:

Additionally, below is the schema part of TargetEntityData

Now scenario is that, I have to assign Value From DataAttribute to right hand side element Approver_DiscomID based on the corresponding Name attribute in left hand side i.e.
if Name=usr_discom then Approver_DiscomID=Value (from screenshot schema it would be like if Name='usr_discom' then Approver_DiscomID='Discom3')
if Name=usr_division then Approver_DivisionID=Value (from screenshot schema it would be like if Name='usr_division' then Approver_DivisionID='PVVNL0920939')
and so on .
Any idea how to do manipulation in xpath.
Thanks
Kumar

A: Solution found!
Need below XPath Expression:
bpws:getVariableData('requestDetails','RequestData','/ns18:RequestData/ns18:TargetEntityData/ns18:TargetEntity/ns18:DataAttribute[@Name="district"]/@Value')

Here @Name refers to TargetEntityData => TargetEntity => DataAtribute => Name
Now there is /@Value is appended to to it. So it will return the Value of attribute Name district & so on.

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