Inducing tissue damage and inflammation to eliminate disease is a long established clinical concept. Historically, Hippocrates is claimed to have said, "Give me the power to induce fever, and I cure all diseases." At the turn of the last century, William B Coley, a surgeon at Memorial Sloan Kettering Hospital, New York (from 1892 to 1936) used a mixed bacterial vaccine (Coley's toxin) in a systemic way to treat patients with metastatic cancer.
The Nobel Prize for Physiology or Medicine was shared in 1960 by Peter Medawar and Frank MacFarlane Burnet for their 1950's work on the 'self non-self' theory of immune recognition. In 1989, Charles Janeway postulated the 'infectious non-self' model and later proposed that the activation of the adaptive immune response is controlled by the evolutionarily older innate immune system. He suggested the principles that might underlie this control.
In 1994, the 'danger theory', proposed by Polly Matzinger, brought a new insight in to adaptive and innate immunity. In 2011, the Nobel Prize for Physiology or Medicine was awarded to Ralph Steinman, "for his discovery of the dendritic cell and its role in adaptive immunity" and to Bruce Beutler and Jules Hoffmann for their "discoveries concerning the activation of innate immunity" by receptor proteins.
In a published interview in May 2012, Polly Matzinger describes the evolution of the 'danger theory', beginning with the questions as to why mothers' immune systems do not kill their fetuses; why your immune system does not turn against you at puberty when you change; why newly lactating breasts do not experience severe immune reactions to the newly produced milk proteins.
In 2012, a BBC Horizon documentary, 'Turned On By Danger' and other appearances at international meetings brought Polly Matzinger's 'danger theory' again to the fore.
The 'danger theory' has caused support and criticism in equal measure, particularly when it was first proposed. But 20 years on, the theory has support from some new experimental approaches. This model is of relevance in the understanding of immune recognition, innate immunity, immune tolerance, transplant immunology and with the increased interest in immune therapy to treat malignancy, to understanding more about immunity to cancer.
The use of the term 'damage theory' to replace the more emotive term 'danger theory' could benefit what is a very challenging model for the understanding of some of the complexities of our human immune response.
The cellular immunologist, Charles Janeway will be remembered for his work on the innate immune system, which he believed to be the controller of immunity. At a time when most research laboratories were interested only in antigen recognition, Janeway asked the very basic question of why was the mere 'foreignness' of a protein not enough to elicit immunity and why did we need to add adjuvant (damaging substances like mineral oil, LPS, mycobacteria or aluminum hydroxide) in order to get a response to a vaccine.
The 'self non-self' model neither predicted nor explained the need for adjuvant. Janeway called this the "immunologists' dirty little secret". He slowly reached an important understanding that caused a major switch in immunological thinking; that immune responses could not occur unless antigen-presenting cells were first activated. Antigen-presenting cells (APC) were activated via pattern recognition receptors (PRRs) that recognized evolutionarily conserved molecules on infectious non-self organisms. Janeway believed that the immune system's default state is 'off' and that it can be 'turned on' by bacteria.
PRRs are found on the surface of APCs, but can also be found in cell cytoplasm and incorporated in the membrane of endo-lysosomes. Stimulation of PRRs leads to activation of the APC to process antigen, up-regulate expression of co-stimulatory molecules and to present antigen to T-helper cells.
When a PRR associated with an APC binds to its corresponding PAMP, the cell begins to efficiently present antigen (Signal 1), upregulate the expression of co-stimulatory molecules (Signal 2), and elaborate cytokines (known as Signal 3) that guide the formation of adaptive cells ready to respond to the inciting pathogen.
The PRRs on antigen-presenting cells (APCs) also recognize 'alarmins' which are released during tissue damage. These 'alarmins' include 'danger-associated molecular patterns' (DAMPs) released following tissue injury or stress and 'pathogen-associated molecular patterns' (PAMPs).
The 'danger theory' postulates that the immune system is triggered by 'danger signals' or 'alarmins', DAMPs and PAMPs.
The release of DAMPs in the extracellular environment functions as a sign of cell death to the innate immune system; this then triggers a pro-inflammatory response. This view, which elaborates on the danger theory, has been called the 'hidden self model'.
When cells die by necrosis, they lose the integrity of their plasma membrane and therefore they release their intracellular contents in to the extracellular matrix, ialong with DAMPs. This is different to cells that die by apoptosis and which are cleared rapidly.
Cytokines including: a-interferon, interleukin-1b, CD40L.
Best known of the 'alarmins', heat shock proteins (HSPs), first described in the 1970s, are highly conserved families of proteins, found in all prokaryotes and eukaryotes. They are involved in protein folding, protection and transport. Their expression is increased when cells are exposed to elevated temperatures or other kinds of stress. HSPs can bind antigens and activate APCs. They can have a dual function, which means that they can be both primal (no need for the previous activation of APCs) and feedback molecules (following the activation of APCs).
'Danger' is difficult to define in immunological terms. Matzinger and her colleagues use several terms that they interpret as equivalent: 'danger', 'damage', 'stress', 'injury'. But how does the notion of 'danger' explain the immune responses to innocuous antigens such as allergens?
The theory is much more precise if its central claim is that every immune response is due to damages to the organism's cells or tissues. It is easier to define what a 'damage' is (for an organism, a tissue or a cell) than what a 'danger' is. In fact, this is the interpretation that Matzinger now proposes when she describes the molecular details of her theory.
it mimics an 'alarm' system.
As Matzinger suggests, the claim that immune responses are due to 'danger' was merely a theoretical suggestion, while the idea that they are due to 'damage' has given rise to several experimental investigations. Therefore, in order to assess the 'danger theory', the most important investigations have been done to define damage signals.
In vitro studies have confirmed that if injected with an antigen, any endogenous activating substances can function as a natural 'adjuvant', which may stimulate a primary immune response, such as is seen in transplant rejection, tumour rejection and some types of autoimmunity.
T-cells only stay activated for about 14 days, after which they die or return to a resting state, requiring both Signals 1 and Signal 2 to be re-activated.
For transplant and tumour immune therapy, this means that T-cells will delete if they bind antigen but do not get co-stimulated by FDCs. Tumour 'vaccines' may need to be repeatedly boosted. Adoptive T-cell therapy (ACT) may need to be given repeatedly if the tumour cells are to be destroyed by immune therapy.
Even though tumour cells possess new surface antigens, according to the 'danger theory', the host regards the proliferating tumour as successful and not as a threat, as long as tumour cells die by apoptosis. By the time the tumour has outgrown its blood supply and cells within the tumour begin to die by hypoxic necrosis, the tumour may be too large for the immune system to destroy.
For a vaccine to be successful, according to the 'danger theory', there needs to be a tumour against which the host still has a few tumour-specific T-cells. Because an early growing tumour is a healthy tissue, not sending alarm signals, it is therefore constantly inducing tolerance to itself.
Tumour vaccination may increase the number of the few remaining tumour-specific T-cells which are present. If these T-cells do exist, repeated vaccine boosts would be required to expand this population further.
Firstly, after the vaccine boost, the T-cells do what they are programmed to do, which is kill one round of tumour cells, then go into a resting 'memory' state. The killing done by a cytotoxic T-cell is apoptotic; it does not cause the release of alarm signals so it does not boost the response, which consequently displays typical immune response kinetics and wanes after about 2 weeks. All the killer cells that were activated by the vaccination go back into a resting 'memory' state. The tumour will continue to grow. So you would need to keep boosting.
Second, even if you have an activated immune system, it will only locate to certain places, so you need to do 'damage' to the tumour to direct the activated T-cells there. Also, if the endothelial cells in the tumour are not activated, the T-lymphocytes are not going to migrate to the tumour.
Third, tissues have ways of communicating with the immune system so that a local immune response clears a pathogen without destroying the tissue itself. A tumour will also have mechanisms to prevent immune-mediated destruction. With application of tumour vaccines, there needs to be a way to overcome the normal tissue signals that instruct the immune system to produce a non-destructive response, to give a strong strong Th1 or delayed-type hypersensitivity killer response to the tumour. The problem is that the signals that the tissues use to educate the immune system are poorly understood and as yet it is not known how to overcome them.
Fourth, if the patient has no remaining tumour-specific T-cells, the vaccine will have no effect, unless the patient is given tumour-specific T-cells with the vaccine.
To overcome some of these practical issues, adoptive T-cell therapy (ACT) has evolved as a new approach in immune therapeutics. The method is to collect naïve T-cells from peripheral blood and engineer them to express cancer antigen-specific receptors, including chimeric antigen receptors (CARs). This approach by-passes the need for APCs. This is an approach that could be applicable to all forms of cancer.
Sixty years on from the 'self non-self' theory of immune recognition and 20 years on from the beginning of the evolving 'danger theory', this is an important time for a 'unified' theory of immune recognition, based on scientific data. The importance of this unification is demonstrated by the increasing investment in, and hopes for, immune therapy for diseases such as cancer.
Dr Dinah Parums is a freelance life sciences writer and journalist.


text:
The Regis School
Bognor Regis, West Sussex
18,000sqm
Dynamic learning environment for students of all ages
The existing Bognor Regis Community College, a specialist Sports College, dated from the 1930s and covered a split site and was a major hindrance to improving educational performance. The existing buildings would have needed substantial upgrading and extension to allow the school to effectively deliver the curriculum. We were appointed to deliver a 1800-place school under the former DfES's Building Schools for the Future initiative. This new campus development involved the design of a new masterplan to integrate the replacement of the infant and junior schools as well.
The new Regis School and its campus form an essential part of the Bognor Regis community. It expresses, in its form and design, an expectation of the highest levels of aspiration and achievement, facilitating the pursuit of these through spacious, flexible, high specification learning and teaching spaces which are coherently organised, accessible to all, innovative and exciting.
Through our design, we sought not just to renew a range of classrooms but to create an environment that lifts the spirits as you enter it. At every corner, pupils feel valued and are encouraged to aspire to great things. Two atriums act as focal points around which the school is arranged, with learning and dining areas sited at the base, minimising corridors and ensuring highly visible learning across the school.
To ensure effective primary to secondary transition support, significant outreach work has been undertaken by the school, particularly in relation to sports. A 'competency' curriculum for years 7 and 8 has been created alongside an associated cluster of generic learning spaces to facilitate different options of designation and deployment across all subjects. Specialist sports facilities have been developed, including a full height gymnasium to host top level trampolining competitions, an external multipurpose MUGA and 'the most popular room in the whole school'; the MYO Fitness Suite. This excellent facility enables students to learn about their bodies (both theoretically and practically), and serves the schools reputation in providing exemplar sports education.
Keen to develop a personalised learning curriculum, the school has created several distinctive areas, such as the product design barn; a collection of design technology, electronic and computer suites of a variety of sizes, grouped together to facilitate multi-age learning across the developing curriculum. The school also houses an art studio, consisting of four art rooms and a resource area in a large single open plan studio on the top floor. With views across the coast, this space allows a creative talent to be unleashed across a variety of ages. Teachers have been given reign to reassess how and what they teach, as well as the way in which they manage the art curriculum.
More details of the facilities the building provides are shown on the school's website.
The advent of a stunning new secondary school has been hugely welcomed by our community. Students, parents, carers and community groups have taken every opportunity to view facilities which have taken The Regis School from a split-site setting reliant on buildings dating back to the 1930's to a bright, dynamic, state-of-the-art learning environment. As well as enhancing student learning it has created opportunities for adults to utilise the facilities and fantastic new technologies.
The new school is complemented by the Arena Sports Centre, the new Southway Primary School, the Arena Skills Centre, the Stepping Stones Day Nursery and our swimming pool. To this will be added a new Youth Centre in 2011. The campus is very much at the hub of the community with over 400 employees and 6,000 users using its facilities every week.
The Regis School reflects the vision of an inspiring learning environment with a library at its heart and a design shaped by its stakeholders. Spirits are lifted by its imposing structure, vibrant colours, flexible learning facilities, and community friendly facilities such as the lecture theatre, dance studio and reception spaces. It sends out a powerful message about the regeneration of Bognor Regis and its aspirations for the young people.
David Jones Headteacher
Stride Treglown > Projects > The Regis School

redpajama_set_name: RedPajamaCommonCrawl


The perfect companion to our 'Grigio Prestazione' and 'Grigio Orangina Nero' Tracksuit Jackets. Elastic waistband with drawstring. Side rafting for added ventilation. Tonal embroidered logo. Branded zip closure at the hem. Fabrics from Italy. 85% Polyamide + 15% Elastane.


Trilix congratulates our talented, hardworking video team for bringing home five Telly Awards — the premier awards honoring national and international video and television work across all screens. The wins can also be attributed to our outstanding clients who always give us great content to capture and share with their audiences.
Established in 1979, the Telly Awards receives over 12,000 entries from all 50 states and five continents. It is one of the most sought-after awards by industry leaders, from large international firms to local production companies and ad agencies. Trilix is pleased to be among this year's winners and past winners, which include companies like ESPN, Fox, HBO, Microsoft, Comcast and many more.


text:
Lieber Weihnachtsmann (Originaltitel: Le père Noël) ist ein französischer Weihnachtsfilm von Alexandre Coffre aus dem Jahr 2014.

Handlung
Der sechsjährige Antoine wünscht sich zu Weihnachten, neben vielen Spielsachen, einmal mit dem Weihnachtsmann in seinem Schlitten zu fahren, damit er seinen Papa besuchen kann, der im Himmel auf einem Stern wohnt – zumindest hatte ihm seine Mutter das immer erzählt. Als Antoine in der Weihnachtsnacht aus dem Schlaf erwacht und in den Abendhimmel schaut, landet plötzlich ein Einbrecher auf seinem Balkon. Da dieser sich zur Tarnung als Weihnachtsmann verkleidet hat, ist der Junge davon überzeugt, dass sein Wunsch nun in Erfüllung geht. Doch der Mann im rot-weißen Mantel klettert einfach weiter zum nächsten Stockwerk, ohne Geschenke da zulassen. Das geht natürlich nicht und Antoine klettert hinterher. Der Einbrecher setzt alles daran den Jungen loszuwerden, aber er hängt sich wie eine Klette an ihn. Als der "Weihnachtsmann" unerwartet von der Polizei kontrolliert wird, kann er dem Jungen schnell noch seine Beute (Münzen und Schmuck) in den Rucksack stecken, sodass er nicht entlarvt wird. So bleiben die beiden auch noch die nächsten Stunden zusammen und das ungleiche Paar zieht durch das winterliche Paris. Antoine "darf" dem Weihnachtsmann sogar helfen, denn nach einem Sturz sind die Kletterkünste des "Weihnachtsmanns" eingeschränkt und er nutzt das unwissende Kind für seine Zwecke aus. Er schuldet jemanden Geld, weshalb er notgedrungen zu dieser List greift. Antoine gefällt es natürlich dem "Weihnachtsmann" behilflich sein zu können und meint, er muss die Sachen nur stehlen, damit der Schlitten des Weihnachtsmanns wieder fliegen kann. Nach einigen Einbrüchen droht das Paar entdeckt zu werden und Antoine kommt zu der Überzeugung, dass dieser Weihnachtsmann wohl doch nicht echt ist. Antoine besteht darauf, die Sachen wieder zurückzubringen. Der Einbrecher hat im Laufe der Nacht eine gewisse Beziehung zu dem Jungen aufgebaut und will ihn nicht enttäuschen und da er eigentlich alles nur wegen seiner Schulden gestohlenen hat, kommt ihm eine Idee. Er lockt den Mann, den er Antoine gegenüber als Knecht Ruprecht bezeichnet hatte, in eine Falle. Er deponiert das Diebesgut unter dem Weihnachtsbaum einer der Familien, die er mit Antoines Hilfe bestohlen hat. Dieser wird nun von der Polizei festgenommen und der "Weihnachtsmann" bringt Antoine wieder nach Hause, wo seine Mutter noch immer schläft und das Fehlen ihres Jungen gar nicht bemerkt hatte.

Tage später geht Antoine mit seiner Mutter in ein Spielzeuggeschäft und trifft dort auf den "Einbrecher-Weihnachtsmann", diesmal aber ohne Mantel. Beide sehen sich an und lächeln.— Weihnachten kann so magisch sein!

Kritik

Cinema.de schrieb: "Klein Antoine freundet sich mit dem Weihnachtsmann an – nicht ahnend, dass der Mann in Rot ein Einbrecher (Tahar Rahim, "Ein Prophet") ist… Flotter Spaß, eher für Große."

Filmdienst.de urteilte: "Besinnlicher Unterhaltungsfilm um das Wunder einer "unmöglichen Freundschaft" zwischen einem geschickten Dieb mit Herz und einem verträumten Jungen."

Weblinks

Einzelnachweise

Filmtitel 2014
Französischer Film
Weihnachtsfilm
Fernsehfilm

redpajama_set_name: RedPajamaWikipedia


text:
Indonesia approves updated plan for Mako gas project
Nov 9, 2022 6:30:am
The updated plan of development was sanctioned by Indonesia's upstream regulator SKK Migas in September this year.
Complimentary, Natural Gas & LNG News, Asia/Oceania, Security of Supply, Corporate, Exploration & Production, Political, News By Country, Indonesia
Indonesia's ministry of energy and mineral resources has approved the updated plan of development (PoD) for the shallow-water Mako gas project in the West Natuna basin, project partner Empyrean Energy said on November 8.
The PoD was sanctioned by Indonesia's upstream regulator SKK Migas in September this year. Mako is licensed through the Duyung production sharing contract (PSC). It is estimated to contain 363bn ft3 of best-case contingent resources potential.
Empyrean revealed on September 9 the revised PoD would entail two phases of development. Six wells will be drilled in the initial phase, while a further two wells will be delivered in the second phase. The first gas is expected in 2025.
Duyung PSC is operated by WNEL, a wholly-owned subsidiary of Conrad Petroleum's Indonesia-focused unit Conrad Asia Energy, which also operates the offshore Mangkalihat PSC in North Kalimantan province.
WNEL holds a 76.5% interest in the licence, with Empyrean owning 8.5% and fellow project partner Coro Energy owning 15%.


Survey design encompasses every detail of survey creation. The difference between a well-made survey and an average survey can be lower drop-out rates, reduced response bias, gathering more beneficial data and provide a better participant experience. Knowing the secrets to creating professional and well thought out surveys will bring your research one step closer to perfection.
Respondent bias is one of three types of response bias that encompasses any error in a survey that can be attributed to the inability or unwillingness to answer a question correctly. Read this article to learn more about respondent bias and how to best combat it in your own online survey research!
Survey bias is a type of response bias referring to any error in a study's results that is created by its survey design. This article discusses the nature of survey bias and provides great tips on how to avoid this in any online survey research!
A key part of creating excellent online surveys is in the proper uses of both open-ended and closed-ended questions. First, we must look at the nature of both question types, their strengths and weaknesses and when they should be used. So let's jump right into things!
The length of your survey should be based on the goals of your research, but also on your targeted respondents and how motivated they are to complete your survey. In this article, learn how to set the optimal length for your survey.
Do you ever wonder exactly what your customer's think of you – what they think you do well, what you do poorly, where they want you to improve, how they compare you to competitors? Then you should consider a customer satisfaction survey!
Staying on top of, and quickly reacting to, your customers' pulse is one of the biggest keys for long term success whether you're selling millions of dollars of computer software, running a repair shop or selling cupcakes on Main Street.
What is often viewed as the most tedious aspect of marketing and business has proved to be the most important. No matter how creative your ad campaign may be, or how many great innovative features your new product may have, nothing replaces customer insight.
The most important factor in carrying out a successful survey is the quality and structure of the questions you ask. At the end of the day, it's what will determine whether you get back useful feedback or not. Poorly structured survey questions can result in incomplete, biased results.


text:
French President Emmanuel Macron, seen at the White House on April 24, 2018, has emphasized the importance of a Cold War-era arms treaty to U.S. President Donald Trump | Brendan Smialowski/AFP via Getty Images
Macron tells Trump about importance of arms treaty
President Donald Trump said the US would abandon a Cold War-era arms treaty.
By	Judith Mischke
French President Emmanuel Macron told Donald Trump about the "importance" of a Cold War-era nuclear treaty that the U.S. president says Washington will withdraw from.
"The President of the Republic underlined the importance of this treaty, especially with regards to European security," Macron's office said in a statement Monday. In their phone call Sunday, Macron and Trump also discussed the death of journalist Jamal Khashoggi and the situation in Syria, Reuters reported.
Trump confirmed Saturday that the U.S. would abandon the Cold War-era arms treaty, arguing that Russia has defied the terms of the decades-old agreement. The treaty, signed in 1987, restricts U.S. and Russian short- and medium-range nuclear missiles.
"They have been violating it for many years," Trump said, according to a White House readout, referring to Russia's cooperation with the Intermediate-Range Nuclear Forces Treaty.
"We're not going to let them violate a nuclear agreement and go out and do weapons and we're not allowed to," Trump said.
Russian Foreign Minister Sergey Lavrov on Monday said Moscow expects Washington to explain its planned exit from the treaty, according to Reuters.
U.S. National Security Adviser John Bolton was in Moscow on Monday for talks. Bolton is due to meet senior officials during his pre-planned visit but may now meet President Vladimir Putin too, the BBC reported.
Judith Mischke


text:
Q: AndEngine, attaching 2 of the same entity affecting collision I am creating a game similar to Glider PRO. In the game, you control a paper airplane and you use air vents to keep you from falling on the floor. When the airplane collides with the air vent, (using collidesWith method) it pushes the airplane up. Now here is the problem, when I attach 2 air vents to the scene,  only the first attached air vent works. The second one doesn't seem to collide with the airplane. I use the onManagedUpdate  method in each air vent to check for the collision. This is my first time coding with AndEngine so any help on this will be greatly appreciated.
Here is the AirVent code:
public class AirVent extends Rectangle
{
private Sprite sprite;
private Glider glider;

public AirVent(float pX, float pY, float pWidth, float pHeight,
        VertexBufferObjectManager pVertexBufferObjectManager,
        ITextureRegion pITextureRegion)
{
    super(pX, pY, pWidth, pHeight, pVertexBufferObjectManager);
    sprite = new Sprite(0, 0, pITextureRegion, pVertexBufferObjectManager);
    sprite.setSize(pWidth, pWidth / 2);
    sprite.setPosition((pWidth / 2) - (sprite.getWidth() / 2), pHeight
            - sprite.getHeight());
    this.attachChild(sprite);
    this.setAlpha(0);
}

public Sprite getSprite()
{
    return sprite;
}

public void checkCollision()
{
    if (glider.collidesWith(this))
    {
        glider.setGravity(glider.getConstantGravity() * -1f);
    }
    else
    {
        glider.setGravity(glider.getConstantGravity());
    }

}

public void applyGliderInteraction(Glider glider)
{
    this.glider = glider;
}

@Override
public void onManagedUpdate(float secondsElapsed)
{
    this.checkCollision();
    super.onManagedUpdate(secondsElapsed);
}
}

And the MainActivity code part:
@Override
protected Scene onCreateScene()
{
    // TODO Auto-generated method stub
    // 1 - Create new scene
    final Scene scene = new Scene();
    Sprite backgroundSprite = new Sprite(0, 0, this.mBackground, getVertexBufferObjectManager());
    scene.attachChild(backgroundSprite);
    roomChanger = new RoomChanger(0, 0, screenWidth, screenHeight, getVertexBufferObjectManager(), scene);
    // 2 - Create the player
    player1 = new Glider(339, 174, this.mPlayerGlider1, getVertexBufferObjectManager())
    {
        @Override
        public void onManagedUpdate(float secondsElapsed)
        {
            if (player1.getLife() == 0)
            {
                // Execute your actions.
                finish();
            }
            super.onManagedUpdate(secondsElapsed);
        }
    };
    scene.attachChild(player1);
    airVent = new AirVent(200, 100, 100, 400, getVertexBufferObjectManager(), this.mAirVent);
    airVent.applyGliderInteraction(player1);
    airVent2 = new AirVent(500, 100, 100, 400, getVertexBufferObjectManager(), this.mAirVent);
    airVent2.applyGliderInteraction(player1);
    scene.attachChild(airVent);
    scene.attachChild(airVent2);
    createControllers();
    return scene;
}

A: I found the problem. The checkCollison() method works, but when I add a second AirVent, the if/else statements battle each other. Removing the else statement from the checkCollision() method fixed the issue but right now, that is not the way I want my game to behave.

redpajama_set_name: RedPajamaStackExchange


Your hospital lab may receive a variety of specimen types and test requests, from any ward or department and at any time, and it can be critical that you route and track them all successfully, while turning around results accurately and as quickly as they are needed. That's why your solution needs to be nimble, flexible and help ensure your quality standards.
The LabLynx Clinical Hospital edition is the right solution for you. No other LIS solution provides the broad range of features and functions you get in your complete LabLynx LIS solution, ease of setup, short implementation time and user-configurability to suit your dynamic needs for decades – and at a price you can fit in your budget.
The centerpiece of the LabLynx Clinical Hospital solution is the LabLynx LIS. The LabLynx clinical LIS is optimized for quick functions and ease of use, so your clients' results are turned around as soon as they are ready. Speed is of the essence, yes, but so is accuracy. Barcoded labels, auto-filled fields and automatically-generated unique specimen IDs all help minimize transcription errors and maintain peak accuracy. And you can achieve the best accuracy and speed possible, meeting all CLIA HITECH standards and more by interfacing your instruments directly with webLIMS.
With LabLynx's cloud-hosted solution, you get all of this and more. There's no additional charge for as many client logins as you need, so physicians or MTs can enter test requests and/or access their reports using the LabLynx online portal from wherever they are. And they can see the status of their own specimens, so you won't be interrupted by phone calls or visits while you get on with your processes.
As a web browser-based application, it can be hosted on your organization's own servers and integrated with EHRs/EMRs, HIS or other hospital systems so results are delivered automatically and immediately, added to charts, etc., and you can access it from any workstation. And its great configurability means you can add and update tests and processes whenever you want to – without costly development.
Your LabLynx LIS solution includes an ERP level of features and functions to give you everything you need, no matter the testing requirements. Need to add a new assay and get results overnight? Generate it in minutes in your LIS, complete with specific ranges and flags for high/low values included in your report automatically.


text:
Leadership Spotlight: Get to know Steve Lepisto
Caleb Heeringa, Communications Coordinator | Caleb enjoys immersing himself in the A/E/C industry and informing audiences about DCI's contribution to state-of-the-art structural development. Preferring a conversational style, he naturally narrates the firm's design approach and project details to professionals in other industries. With a knack for adventure, he enjoys international travel and exploring the back corners of Washington's wilderness.
Since the 2013 merger between DCI and SDE, Steve Lepisto has played a vital role in the San Francisco office – acting as a bridge between the two firms and helping transfer his institutional knowledge to a new generation of young engineers. We asked Steve about his career in engineering, the merger and the future of DCI+SDE in the booming Bay Area market.
What attracted you to engineering as a career?
I was always attracted to things related to architecture and building. I started in high school with architectural drafting, then entered Cal Poly San Luis Obispo in the architecture program. After a year I realized that I was better at the math side of things than the artistic side, so I switched to architectural engineering, which allowed me to apply my math skills to architecture.
What drew you to SDE as a firm?
I liked the diversity of SDE's projects. At the time they were working on new office buildings, office interiors, single-family homes, multi-family residential, and renovation projects. One of my first projects with SDE was the first phase of the 3COM corporate campus in Santa Clara, California, which went on in later phases to include office buildings, a manufacturing building, a free standing parking structure, and multiple office buildings over a parking podium.
What is the biggest SDE attribute that helped the company keep up with the highs and lows of the Bay Area market over the years?
The diversity of projects and clients helped ensure that we could always find work – we could rely on education or government projects when the market cooled in the private sector, for example. The loyalty of clients also played a huge part – we knew our reputation would ensure that we'd be the first they called when a project came up. The unfortunate disasters of the Oakland Hills fire and the Loma Prieta earthquake also happened during some slow periods, leading to lots of new homes and seismic retrofit work.
It's been two years since DCI and SDE merged. How has the transition gone? In what ways do the two firms complement each other?
The transition has gone very smoothly. We had a lot of new things to learn in terms of DCI business systems (timesheets, computer and network setups, CAD standards, etc.), but those systems work very well and all of the DCI people were very helpful. The approach to structural engineering at SDE was very similar to that of DCI, so the DCI motto of "Service, Innovation, and Value" felt very comfortable to us and to our long-time clients. At the same time, the merger and the DCI transplants from Seattle brought a new energy to our office.SDE brings a lot of experience working with the local agencies and on many affordable housing projects. DCI brings a lot of experience with private developers.
Describe one of your favorite Bay Area engineering projects you were involved with, either professionally or personally.
The most fun I've ever had on a job was when I worked with some preservation architects for the evaluation of a historic ice shed near Merced Lake in Yosemite National Park. It required backpacking into the site to evaluate the structure. The hike was about 14 miles each way, peaking at 10,100 feet and ending in Yosemite Valley at 4,000 feet. We stayed two nights at the Merced Lake High Sierra Camp.
In your years of experience designing in San Francisco, what do you think is unique about the city? Is the structural engineering process different there than it would be in another city?
Projects in San Francisco are usually constrained by many more parameters than those outside of the city, such as small parcel sizes, steep hillsides, neighboring buildings, poor soils, the desire for multiple uses, and a political atmosphere that requires significant community input. These tend to make the buildings more architecturally and structurally complicated, and the result is that each project is more unique. There's no "typical" blueprint for designing in San Francisco.
Is there something that you often hear from clients regarding DCI/SDE's service? What makes the firm stand out in the San Francisco market?
Our clients like our responsiveness and our problem-solving approach, whether it's finding a way to make the structure most efficient or a way for the structure to accommodate a unique architectural feature.
Multifamily development is booming in San Francisco. Where do you see the market going in the coming years? What do you think our industry needs to do to adapt and keep up with the changing market?
Housing has been in short supply in the Bay Area for many years, so the current boom in multifamily development will not satisfy the backlog of demand in the near future. The trend to more urban living will keep the demand high in places like San Francisco and will also influence the designs in more suburban areas. Residents are demanding more services in or near their building, meaning more mixed-use projects.
What advice would you give to someone who is just starting their career as a structural engineer?
Try to get as much variety in projects as you can so that you can be exposed to all types of materials and systems. You may find a niche that you really like and want to concentrate on, or you may prefer to maintain a broad spectrum of work.
What is your favorite part of the job – the nuts and bolts of design work? Client relations?
I enjoy the problem-solving aspect of design, fitting together all of the pieces of the puzzle to provide not only an efficient structural solution but one that benefits the other pieces of the puzzle.
< Back to News & Press


I was always taught that the way in which one handles adversity is a sign of one's true character. That's true. What I learned from President Bush, though, is that how you deal with success is also a sign of one's character.
From 1985 to 1990, I was George H.W. Bush's personal aide, which meant being with him from the start of his day until late in the evening when his events were finished. At one moment, I was managing his briefing materials and carrying his bags, and the next, I was determining whether an urgent phone call actually merited interrupting the Vice President.
I confess to occasionally using that consideration for others to my advantage. Keeping the president on schedule generally wasn't that difficult; he was fanatical about being on time. Occasionally, however, he'd linger at an event. My "secret weapon" was to say to the president, "Sir, I'm sorry, but we've got to go. The agents have shut down the motorcade route." That was enough to send him racing to the limo — determined that the locals not be inconvenienced.
For such a decorated war hero — in fact, one of the youngest Naval aviators of his time — he didn't talk all that much about his service during World War II. Over time, however, it was clear to me from his speeches and seeing him with others with whom he'd served, just how formative his military service was to him.
Like many veterans, he could be nostalgic, and sometimes emotional, especially when he was together with shipmates from the USS Finback (SS-230) who rescued him when his plane was shot down during WWII. As he was preparing to run for president in 1988, he struggled a bit with how to talk about his experiences during the war.
Many years later, he still felt great distress over his fellow crewmen who were lost when their plane was shot down. Nonetheless, I believe his time in the service reinforced his dedication to serving others throughout his life.
"Sending someone else's son or daughter into combat is the hardest decision a president ever makes," he said years later.
In January 1986, after having been the vice president's aide for only a couple of months, we were in his West Wing office watching the launch of the Challenger space shuttle (the launch of a NASA space shuttle was still a really big deal at the time, and this particular mission included the school teacher Christa McAuliffe). Then, the unthinkable happened: the Challenger exploded a minute after liftoff. The world stopped. Within a couple of hours, we were on Air Force Two, flying to Florida to be with the families of the Challenger crew.
I'll never forget how moving it was to witness the vice president express his grief and that of the nation. It's well known that H.W. Bush was a "crier," but his emotions were always sincere, and in sharing the pain and sadness with the Challenger families that day he helped to ease their burden.
One of the president's great strengths was his ability to comfort and connect with people. Humor was a big part of it. He loved to laugh, and he loved to make people laugh. He and Mrs. Bush found humor in everything and laughed all the time. His humility and integrity — his sense of humor and sincerity — made him a magnet to the people who came into his orbit.
During the time I served at George H.W. Bush's side, I admired his abiding concern for others, from world leaders to the humblest in the room. In a letter the president wrote to me as I was leaving the post as his aide, he described the characteristics he valued most in a person.
Timothy McBride was a member of George H.W. Bush's vice presidential and presidential staffs, serving as the president's personal aide or private secretary for five years.


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text:
Kanye West's Album of the Year Grammys nomination was reportedly last-minute addition
Ye is also nominated in the Best Rap Album, Best Melodic Rap Performance and Best Rap Song categories.
Kanye West's Donda was a last-minute addition to the 2022 Grammy Awards Album of the Year nominees, The New York Times reports. According to the outlet, Ye's 27-song effort and Taylor Swift's Evermore were added to the nominations list on Monday (Nov. 22) — one day before the full list was announced — after the Recording Academy decided to expand the number of nominees from eight to 10.
Kanye's Donda is also nominated for Best Rap Album, and he's also nominated in the Best Melodic Rap Performance and Best Rap Song categories.
The decision also impacted other major categories, The Times reports, including Record of the Year. Lil Nas X's "Montero (Call Me By Your Name)" and ABBA's "I Still Have Faith in You" were last-minute additions to the category on Monday.
The newly expanded Song of the Year category also brought in nominations for Doja Cat's "Kiss Me More" and "Right on Time" by Brandi Carlile. Baby Keem and composer Arooj Aftab were also reportedly the latest additions to the Best New Artist category.
The Times determined which artists were last-minute additions after obtaining a Grammys "final nominations list," which the outlet reports was curated several days before the official list was announced on Tuesday (Nov. 23). The list only included eight nominees for the four major categories.
Recording Academy CEO Harvey Mason Jr. celebrated the categories' expansion from eight to 10 nominees on Tuesday, saying it made "room for more music, more artists and more genres, and to embrace the spirit of inclusion."
"We saw it as an incredible opportunity for us to honor more artists and shine a light on more great music and potentially offer a greater opportunity for more genres of music to be honored," he added to Variety. "It's something that we've talked about for quite some time, but it ended up happening fairly recently. We looked at the voting and the amount of submissions [for the 2022 Grammys] and saw it as a great opportunity."
As reported by REVOLT, the 64th Annual Grammy Awards will be broadcast from Los Angeles' Staples Center on Jan. 31.
JAY-Z becomes most-nominated artist in Grammys history, surpassing Quincy Jones
YoungBoy Never Broke Again, Jazmine Sullivan, J. Cole and more nominated for 2022 Grammy Awards


1) Remove all duplicate characters from a string. Thus, "aaabbb" becomes "ab" and "abcbd" becomes "abcd".
2) Replace all runs of consecutive spaces with a single space. Thus, "a.b" is unchanged and "a..b" becomes "a.b", using a dot to make the space visible.
Your task is to write the two requested functions. When you are finished, you are welcome to read or run a suggested solution, or to post your own solution or discuss the exercise in the comments below.
The obvious haskell solutions are nub and nubBy (== ' '). I don't know if thats cheating though.
Hmmm, the formatter messed up my code – here's the plaintext form.
I tried to do something slick with Python's groupby for the first one, but it would require sorting the string first (and therefore destroying the order). Similar attempts with set, dictionaries, or Counter also destroyed the order due to hashing.
Your rem-dup-char won't work for Unicode!
@Razvan: Instead of creating an intermediate list and then concatenating it into a string, you could use with-output-to-string. I think that would be a lot more efficient, and not more complicated to code.
In Common Lisp, easy solution to the first problem :).
Unfortunately, the previous Perl solutions have problems– the "eliminate duplicate letters" solution (revised) does not preserve the order of the letters, and the "squash spaces" solution would squash all non-alphanumeric characters, not just spaces.
Oops, either I forgot a closing brace on snippet #1, or it got lost somehow. Perl programmers would know that there should be a closing brace to match the subroutine declaration. Sorry.
I see there aren't many haskell solutions posted here.
//and the HashSet.Contains method is an O(1) operation.


You are so curious about what some people really find in gambling clubs. Are these places really safe for those who would like to spend an afternoon break or evening pleasure enjoying a particular game that these clubs offer? Should you also try it for yourself just to see what the excitement is all about?
Not one to be easily influenced by word-of-mouth, a few designed-to-impress advertisements, or the latest glossy and enticing reads about these places in magazines or online bookstores, you may probably find yourself puzzled by these places. And, perhaps, in the midst of your curiosity, you would choose to devote some of your thinking moments to piecing the puzzle on these areas of leisure (as called by some) and the people who go there.
What do these gambling clubs really have that continue to thrill and entice many people to check out their places and also decide to partake of the games there? What is this interesting pull that these gaming areas hold?
If you would really investigate on certain matters of interest, you would see these things that may help you to think if these areas are really safe or not, and if you should try them yourself.
* Most of these places have legal rules and regulations that coincide statewide. Although you may find that there are some areas where these places are prohibited to operate, there are a still a lot of states that allow these gaming arenas to exist. It's really different from one area to the next. If you've managed to get the good and trustworthy ones, you will see that these have rules that are indeed legal and player-friendly.
* Most place much importance in the timely disbursement of winnings to players. As stated in the house rules, most of these places pay their players accordingly when the players had won on certain playing sessions. Since customer care is important, those who work in this business see to it that the players are treated well and given their winnings when this is due.
* They are backed up by legitimate institutions. Gambling clubs that are worthy enough to learn more of usually have affiliations with legitimate institutions. These institutions are some of the good businesses that you are aware of in terms of how they operate or how their foundation stands.
So, are gambling clubs a safe place for entertainment and leisure? You bet. So, quit being curious. Go ahead and learn more by stopping by and taking a look inside. You may probably see that it's all worth the gaming experience, and you may want to go back again for more just like the others who continue to do so.


The sales of forms for admission into the School of Health Information Management (SHIM), Obafemi Awolowo University Teaching Hospital Complex(OAUTHC), Ile-Ife for the 2018/2019 academic session is currently underway.
Interested candidates must have sat for the UTME examination.
They also must have obtained five (5) O'Level credits at not more than two sittings in English Language, Mathematics, Biology/Health Science and Chemistry to be eligible to apply.
NOTE: In addition to the requirements stated above, the final admission into the school shall be based upon the JAMB-UTME approved cut-off marks as will be decided by JAMB for Polytechnics, Monotecnics and Colleges of Education in the 2018/2019 academic session.
(v) Any other subject such as Physics, Agric Science, Geography and Economics.
Candidates are required to must have sat for the 2018 JAMB examination and must meet the cut-off points (as stipulated by JAMB) and had chosen the school as their first choice in JAMB applications.
Selection of candidates will be based on the possession of requisite academic qualifications, good performance in both the written examination and oral interview.
Selected candidates will be required to pass the medical fitness examination.
School of Health Information Management, Obafemi Awolowo University Hospitals Complex, Ile-Ife, P. M. B. 5538, Ile Ife, Osun State.
Completed application forms must be returned to the Ag. Head of School on or before 22nd August, 2018.
The screening exercise will come up on Wednesday, the 28th day of August, 2018 by 9 am while the Interview will hold on Thursday 29th August, 2018.


text:
Vegan students: »You end up feeling lonely if you can't share a key part of your identity«
The vegan students' club at UCPH.
image: Anne Ubbesen
Clubs — Jakob Bredahl and Shivanii Hansen wanted a vegan alternative to the University of Copenhagen canteens. Now they meet up with their peers to discuss animal ethics and their philosophies of life.
by: Anne Ubbesen
Studenterjournalist
»We're right now in the best canteen at the University of Copenhagen, Wicked Rabbit, and it has a lot of plant-based options,« says Jakob Bredahl as he dishes out quinoa sauce onto his plate.
»It's easy to be vegan here.«
Vegan students at UCPH
Who: For anyone who would like to take part in the vegan community. You don't have to be a vegan to be a part of it.
Where: In the KUA canteen, Wicked Rabbit
When: It varies, stay up to date on their Facebook page
So what now: Follow the club's Facebook page
There is a long queue at the Faculty of Humanities' vegetarian canteen. The menu of the day consists of root vegetable soup and spaghetti 'bolognese' made from lentils and quinoa, and Jakob Bredahl waits for a long time to pay for his lunch.
»Shivanii got hold of me a month ago because she had an idea of starting a UCPH vegan group,« he says. »When we met, we quickly came to talk about the potential for getting UCPH cafeterias to be more plant-based.«
After the food has been paid, he approaches a table where the said Shivanii Hansen is surrounded by five other students.
They are all vegans, and today 3 May, they have turned up for the very first lunch meeting of the Vegan students club at the University of Copenhagen (UCPH).
More and more vegans
»The idea behind this club is to create a space where people who live in the comfort of their studies at the University of Copenhagen can meet up, get to know each other, socialize, eat together and perhaps in the longer term, also start something that is a little bit more student political,« explains Jakob Bredahl. He is doing his master's degree in psychology.
»We would like to start by contacting the canteens, and informing them about all the advantages of switching to something more plant-based,« Shivanii Hansen adds. She has often had to go home hungry from her own CSS campus, because there have been no vegan alternatives.
She pokes her fork into the food in front of her and twirls the spaghetti before taking a bite. She explains that it pretty much tastes like the original dish – just a bit better.
»More and more students are moving in a plant-based direction. And this is a direction that the canteens would like to encourage,« says Jakob Bredahl and explains that there are already around 125 members in the UCPH vegan student group he has set up on Facebook.
He thinks there are a lot more vegans at UCPH than in the Facebook group, but many of them do not know other vegans at their place of study.
»You can feel left out on your own with it, when you don't know others. And it's a really annoying thing to have to be alone with, when there are so many positive aspects of the vegan diet that can be improved if you meet and talk about the options.«
The Wicked Rabbit canteen serves vegetarian and vegan food and is on the South Campus KUA.
Animal ethics as a motivator
While Jakob Bredahl talks about the club, the other members' conversation drifts back and forth across a table that is decked out with their plant-based dishes.
»You quickly become friends when you see the world in the same way,« Shivanii Hansen explains and smiles to the others. On the face of it, the group of students resembles any other group of friends, and the conversation is on everything from lectures to lecturers, and from training to travelling.
All until the chat turns to veganism. Then an intense conversation starts about what motivated their choice of diet. Everyone agrees that the prime motivation is the animal ethics aspect of it.
»It is about not hurting animals when it is not necessary. It is an ethical conviction,« says Jonas Krarup, who is a student of professional communication. »Today, of course – and this is very understandable – we also talk about health and climate, and that is good. But when we cut to the chase, we end up with the fact that it is about the animals. No humans want to see animals suffer.«
Jakob Bredahl listens with interest, and nods. He explains that he himself went vegan three and a half years ago after talking to his brother, who for many years had refrained from eating animal products for the sake of the animals.
»It took me a few years to put myself sufficiently into the mindset, but then I felt compelled to make the same decision. I had finally also reached a point where I did not feel able to justify anything else to myself.«
Jakob Bredahl started the club with Shivanii Hansen
The lunch break is coming to an end, and the student numbers thin out in the canteen. The vegan group clears a table, and one of them leaves the establishment to go to a lecture. The others stay seated. There are a lot of things that still need to be decided.
»There is this workshop in the animal rights house Dyreretshuset today. We can go there together,« says Jakob Bredahl and explains that a Lebanese animal rights activist is in Denmark at the moment to give talks.
Jakob Bredahl hopes that, in the long term, the club can organize a series of academic events. He has been able to get the Lebanese speaker to do a presentation at the central campus CSS.
»In the long term I would like to make sure we get some academic expertise. But this is something that we all have to figure out together.«
No sooner said than done. Around the table, there is a discussion about what the club is, and what needs to be done. Several of those present have previously been involved in vegan activism, but not everyone is interested in this.
One idea is accepted by the whole group: The club needs to be a place where you can relate to each other's daily lives and share your experiences.
»A place where you share the same basic outlook,« says Shivanii Hansen, and everyone nods. Jakob Bredahl speaks up.
»I think that you can end up feeling lonely, if you can't share a key part of your identity with the people that are around you. That is why this community is important.«
And with these words, the meeting is adjourned. Some have to go home and write their master's theses, others have to go to an animal rights workshop.
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We're also pleased to announce that our good friend Dan Abela from Voices will be handling the tracking and recording process. As well as playing Bass for Voices Dan has mixed and produced both Voices albums and (amongst others) records for Sarah Jezabel Deva and The Antichrist Imperium. Dan will also be mixing and producing our entire album as well as handling recording for the keys and vocals.
Once again we will be working with another good friend of ours for tracking the guitars, Mike Smith and Velocity Raptor Studios here in North Wales. More news, studio diaries, interviews and updates as to follow as we go.


text:
Use("common/Const");
Use("common/Log");
Use("common/Position");
Use("common/Creature");
Use("common/Skill");
Use("common/Task");

-- Follow (standard attack range)
-- progress: progress state
-- id: who is responsible for the task
-- origin: where the task started
-- time: when the task started
-- hp: hit points at task creation
-- sp: skill points at task creation
-- leash: following distance
-- resilience: modified resilience value
-- tranquility: modified tranquility value
-- target: desired target to follow
Follow = {};

function Follow.Create(_pet, _target)
  local instance = Task.Create(_pet);

  instance.target = _target;
  instance.leash = _pet:GetLeash();
  instance.resilience = _pet:GetResilience();
  instance.tranquility = _pet:GetTranquility();

  --[[ Follow Target ]]--
  function instance:Execute()
    Debug("Follow.Execute()");

    if (GetV(V_HP, self.id) < (self.hp / self.resilience)) then
      -- We've taken a lot of damage since the task began. Abandon this
      -- task and try to do something else.
      Info("Follow.Execute() interrupting task")
      return self:Progress(PROGRESS_FAILURE);
    end

    -- Try to keep in leash range.
    return self:Progress(self:Approach(Position.Find(self.target), self.leash));
  end

  return instance;
end

redpajama_set_name: RedPajamaGithub


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before and their knowledge seemed superficial at best.
have the luxury and time to dig so deep into that area as I have done.
sense having all the motion sensors in one spec.
> > work out (history lesson, but I'd be happy to be proven wrong).
> an explainer doc if necessary.
> > or to be used as learning resources.
> > normative spec work (because of Priority of Constituencies).
> > https://www.w3.org/TR/css-2017/ updated as new concrete sensors emerge.
> still stand whether or not the explainer part is spec-contained.
Next message: W3C Webmaster via GitHub API: "Weekly github digest (sensors, ambient-light, accelerometer, proximity, gyroscope, magnetometer, orientation-sensor, battery, wake-lock, html-media-capture, vibration)"


IOT Based Load Control Over Standalone Wi-Fi System first of all lets start with introduction to IOT Based Load Control Over Standalone Wi-Fi System. The IOT (Internet of things) based load control over standalone system is very advanced home automation system. In this modern world, every men or women do want to move anywhere, they just want to click the button and done everything. Keep all these things in mind, we are introducing IOT based load control over standalone wi-fi system. By using this system, we can easily control the home appliances automatically through the wi-fi system. Here we have designed this system with the help of microcontroller 18F452 which is belongs to pic family, transformer for connecting this system directly to the wapda power supply, wi-fi module for controlling this system through the wi-fi, optocoupler for isolating two signals and voltage regulator for regulating the dc voltage for supplying the power to the microcontroller, wi-fi module and other component of this system.
Wi-Fi Module: The wi-fi module in IOT based load control over standalone system is used for connecting this system to the wi-fi because this system is totally controlled through the wi-fi. When any one would be send the instruction through the mobile phone or webpage for controlling the load, then these instructions would be received by the wi-fi module and send the signal to the microcontroller to switch on or off the connected load. This is very significant component of this system.
Optocoupler:In IOT based load control over standalone wi-fi system, the optocoupler is used for coupling the wi-fi signal to the microcontroller, without any connection between them. Which consists of photo diode or photo transistor and light emitter. When the light which comes from wi-fi module falls on photo transistor or photo diode then it sends the signal to the microcontroller for on or off the connecting load.
Microcontroller PIC 18F452: In this IOT based load over standalone wi-fi system, the microcontroller is used for controlling this system atomically, which consists of ram, rom and processoretc and is programmed with the help of mikro c language. It is interfaced with optocoupler for receiving the wi-fi signal. When any one send the data or load control signal from smart phone then this signal is received by the wi-fi module and then this signal is received by the microcontroller through the optocoupler. The microcontroller, which is already programmed as per load control signal and then send the load control signal to the output load for on or off this load. This load can also be controlled manually by using the simple switch with this load. It we see the working of a microcontroller then; the microcontroller plays an important role in this IOT based load control over standalone wi-fi system.
Transformer:The transformer, which works on the principle of mutual induction is used for step down the 220v ac to 12v ac for operating the other electronics components. By using this transformer, we can connect this system directly to the wapda power supply.
Bridge Rectifier:In IOT based load control over standalone system, the bridge rectifier is used for the converting the ac voltages into dc voltages for operating the microcontroller, LCD display and wi-fi module.
Voltage Regulator: In IOT based load control over standalone wi-fi system the voltage regulator is used for regulating the 12 dc, which is output of bridge rectifier to 3.3-volt dc and 5 v dc.
LCD Display:The LCD display, in this load control over standalone system is used for displaying the data which is send from the smart mobile phone or displaying the status of connected load.
Triac:The triac is an electronic component, which conducts the current in both direction therefore it is called bidirectional triode thyristor or bilateral triode thyristor. In IOT based load control over standalone wi-fi system the triac relates to the output load for make on or break the output load.
Load:In this IOT based load control over standalone system, the bulb is used as an output load.
The working of this IOT based load control over standalone wi-fi system is so much simple. When any one or consumer want to control the home or office load then he just opens the webpage from his mobile phone and check the status of his home or office load. Suppose if he wants to off some load then he just clicks the off button from his mobile phone. His mobile phone sends the signal to the wi-fi module which is interfaced with microcontroller through optocoupler. The microcontroller which is interfaced with the triac component. The triac component is connected to the output load. When the microcontroller sends the off-load logic to the traic then the triac off the output load.So by using this system we can easily control our home or office load.
This IOT based load control over standalone wi-fi system can be used in your homes as for home automation system for reducing the bill.
By using this system we can reduce the man power.
By using this system we can easily the check the load status of our home or offices from anywhere and anytime.
This system can directly connect to the load supply, no extra power supply is required for this system, this feature also reduce the cost of this system.


text:
using System;
using System.Drawing;

namespace Ys.Image
{
    internal static class DIB
    {
        public static byte[] Build1bppDIB(
            byte[] bitmapData, int width, int height, Color foreColor, Color backColor)
        {
            var bfh = new BITMAPFILEHEADER() {
                bfType         = 0x4D42,
                bfSize         = 62 + bitmapData.Length,
                bfReserved1    = 0,
                bfReserved2    = 0,
                bfOffBits      = 62
            };

            var bih = new BITMAPINFOHEADER() {
                biSize             = 40,
                biWidth            = width,
                biHeight           = height,
                biPlanes           = 1,
                biBitCount         = 1,
                biCompression      = 0,
                biSizeImage        = 0,
                biXPelsPerMeter    = 0,
                biYPelsPerMeter    = 0,
                biClrUsed          = 0,
                biClrImportant     = 0
            };

            var palette = new RGBQUAD[]{
                new RGBQUAD(){
                    rgbBlue     = foreColor.B,
                    rgbGreen    = foreColor.G,
                    rgbRed      = foreColor.R,
                    rgbReserved = 0
                },
                new RGBQUAD(){
                    rgbBlue     = backColor.B,
                    rgbGreen    = backColor.G,
                    rgbRed      = backColor.R,
                    rgbReserved = 0
                }
            };

            byte[] ret = new byte[62 + bitmapData.Length];

            byte[] bytes;
            int offset= 0;

            bytes = bfh.GetBytes();
            Buffer.BlockCopy(bytes, 0, ret, offset, bytes.Length);
            offset += bytes.Length;

            bytes = bih.GetBytes();
            Buffer.BlockCopy(bytes, 0, ret, offset, bytes.Length);
            offset += bytes.Length;

            bytes = palette[0].GetBytes();
            Buffer.BlockCopy(bytes, 0, ret, offset, bytes.Length);
            offset += bytes.Length;

            bytes = palette[1].GetBytes();
            Buffer.BlockCopy(bytes, 0, ret, offset, bytes.Length);
            offset += bytes.Length;

            bytes = bitmapData;
            Buffer.BlockCopy(bytes, 0, ret,  offset, bytes.Length);

            return ret;
        }

        public static byte[] Build24bppDIB(byte[] bitmapData, int width, int height)
        {
            var bfh = new BITMAPFILEHEADER() {
                bfType         = 0x4D42,
                bfSize         = 54 + bitmapData.Length,
                bfReserved1    = 0,
                bfReserved2    = 0,
                bfOffBits      = 54
            };

            var bih = new BITMAPINFOHEADER(){
                biSize             = 40,
                biWidth            = width,
                biHeight           = height,
                biPlanes           = 1,
                biBitCount         = 24,
                biCompression      = 0,
                biSizeImage        = 0,
                biXPelsPerMeter    = 0,
                biYPelsPerMeter    = 0,
                biClrUsed          = 0,
                biClrImportant     = 0
            };

            byte[] ret = new byte[54 + bitmapData.Length];
            byte[] bytes;
            int    offset= 0;

            bytes = bfh.GetBytes();
            Buffer.BlockCopy(bytes, 0, ret, offset, bytes.Length);
            offset += bytes.Length;

            bytes = bih.GetBytes();
            Buffer.BlockCopy(bytes, 0, ret, offset, bytes.Length);
            offset += bytes.Length;

            bytes = bitmapData;
            Buffer.BlockCopy(bytes, 0, ret,  offset, bytes.Length);

            return ret;
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    }
}


In communing with himself he finds not deadly boredom and melancholy but an inner partner; more than that, a relationship that seems like the happiness of a secret love, or like a hidden springtime, when the green seed sprouts from the barren earth, holding out the promise of future harvests. ~Carl Jung, Mysterium Coniunctionis, Para 623.
Salome's performance was deification. ~Carl Jung, Liber Novus, Page 253. Footnote 211.
Just as a man brings forth his work as a complete creation out of his inner feminine nature, so the inner masculine side of a woman brings forth creative seeds which have the power to fertilize the feminine side of the man. ~Carl Jung, CW 7, Para 336.


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BACKYARD BROADCASTING LOCAL NEWS JULY 12, 2019
MAN FLEES POLICE, CRASHES VEHICLE, FLEES AGAIN
A Williamsport man ran from an accident scene after he fled from police and crashed his car following an officer's request to search his vehicle for suspicion of marijuana. Twenty seven year old Earl Taylor of Cherry Street, was stopped by police, who suspected Taylor of smoking the drug in the parking lot of the River Valley Regional YMCA. Taylor then fled the interview in his 2001 Chrysler Voyager van, crashing into a utility pole a few blocks away. Taylor then exited the van and ran from the accident scene. Police captured Taylor in a nearby alley after 6pm Wednesday night and found him with almost 24 grams of marijuana. Police took Taylor to UPMC Susquehanna for treatment, then to the Lycoming County Prison in lieu of 75 thousand dollars bail.
PENN TOWNSHIP MAN ARRESTED IN DOMESTIC INCIDENT
A domestic dispute has landed a Penn Township man in jail. Selinsgrove state police say that 41 year old Joseph Loduca assaulted and threatened a female victim at a home along Devon Court at 5:30 pm Tuesday. Loduca was taken into custody and arraigned on the charges. He is in Snyder County Prison on 75 thousand dollars straight bail.
JEWELRY, CASH STOLEN IN HOME ROBBERY
Police say they are investigating an incident at a home in Snyder County in which a burglar broke in to the home and stole cash and jewelry worth over 6 thousand dollars. Selinsgrove State Police told WKOK that the robbery occurred June 22nd at a house on Penn Street in Center Township. Items stolen include wedding rings and over 4 thousand dollars in cash. The investigation is ongoing.
STORMWATER FEES COULD CHANGE IN BOROUGH
Residents in the South Williamsport Borough may be the first local area to adopt fee-based revenue instead of tax-based for stormwater usage through the Lycoming County Water and Sewer Authority. The Williamsport Sun Gazette reports that the borough will adopt a four tier fee chart which is dependent on average amount of acreage owned by residents there. The authority says they are working on creating a system of reporting and regulation that will adhere to the Chesapeake Bay Pollution Reduction Plan.
CODE VIOLATIONS RAMPANT IN CITY
Code violations in the City of Williamsport for overgrown lawns and garbage at the curb are numerous, according to the city codes administrator, Joseph Gerardi. According to the Sun Gazette, Gerardi says there it's the worst year for grass and weeds with the heat and wet weather and some residents also ignore the code restrictions. Authorities are struggling to keep up with the violations in the city with only 4 code enforcement officers to dole out the warnings. A property owner can be charged up to 2 thousand dollars per code violation.
LOCAL VO-TECH GETS SURPRISE GRANT
State Senator John Gordner of Berwick and Representative David Millard of Millville presented a million dollar grant to Columbia Montour Area Vo-Tech School in Bloomsburg on Wednesday. WKOK reports that the funds are from the state Department of Community and Economic Development and will help the school add workshop space, allow more students to be enrolled, and provide local employment. The surprise grant will boost the funding for the already planned expansion at the school.
TWO DISORDERS ADDED TO MEDICAL MARIJUANA LIST
Two disorders have been added to the conditions that can qualify people to obtain medical Marijuana according to the Pennsylvania Health Department. Health Secretary Dr. Rachel Levine says the recommendation to include anxiety disorders and Tourette's syndrome to the list came from the state Medical Marijuana Advisory board and physicians will be able to include it with other therapeutic approaches beginning July 20th. Over 110 thousand state residents are certified to use the medical marijuana program.
MILTON TEEN SPEAKS TO CONGRESS
A Milton teen has traveled to Washington DC to speak to Congress to advocate for juvenile diabetes recently. WNEP reports that 16 year old Adriana Richard was chosen out of 1000 other kids with diabetes to speak about her experiences. The Milton High School senior who wrote a book about the disease, joined other students in the nation's capital as part of the Children's Congress in conjunction with Senator Bob Casey's bill to cover costs for most children with type 1 diabetes.
Rangers over the Astros 5-nothing
Wimbledon Women's Tennis Singles
American Serena Williams defeated Czech Republic's Barbora Strycova 6-1, 6-2
Romania's Simona Halep defeated Czech Republic's Elina Svitolina 6-1, 6-3
NY Penn League
Williamsport Crosscutters beat the Vermont Lake Monsters 3-2
9-11 Softball
Loyalsock defeats Jersey Shore 17-7 for the District 12 Title


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Privacy PolicyWell Prevail2019-02-06T10:07:26+00:00
On wellprevail.com, we run several third-party services and use cookies to optimize your browsing experience. Some countries now require different privacy disclosures, so please read the entire policy to understand our practices fully. By using wellprevail.com, you agree to the retention and use of information by this Privacy Policy.
When you subscribe to our email newsletter, we may retain a record of your name, IP address, email address, and the emails you open.We collect the information so that we can more precisely recommend you with health advice, buying guides, and deals for the products or services that we endorse.
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Wellprevail.com uses cookies to track how you navigate the site, what is of interest to you, and how our marketing strategy is performing. You may block most cookies by responding to the cookie consent notice that appears when you visit wellprevail.com as well as by adjusting your browser settings. If you turn cookies off, your site experience may be less efficient.
We neither sell nor transfer your Personally Identifiable Information to external parties unless we provide users with advance notice. This excludes website hosting partners and managers who assist us in our website operation, so long as your information is kept confidential. We may also release information in compliance with the law, enforce our site policies, or protect our users' rights, property or safety. However, non-Personally Identifiable Information may be released to external parties for advertising and marketing.
We may offer third-party products or services on wellprevail.com or in the newsletter. These third-party sites have independent and separate privacy policies. We, therefore, are not responsible or liable for the activities of these third-party sites. We also allow third-party behavioral tracking. Nonetheless, we seek to protect our integrity and welcome any feedback via wellprevail@gmail.com.
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New Facebook Layout 2016 - Could this be a new layout for Facebook?
Earlier today, the team at 123 Internet noticed Facebook looking a little different... A slightly sleeker, more modern layout appears to be rolling out over the network. Have you spotted it yet?
We like it! It's clean, and that's the trend at the moment. The left hand banner offers not only attractive design but a functional layout, optimising the site for a better User Experience. It is clear that we now have more room for the banner image as well as making CTA's more obvious. The focus has become a lot more about the look, you can put your own stamp on it.
We have noticed that the new layout is not yet available for all users, but this is common with Facebook updates, a slow roll out allows for a smoother transition.
A positive move by Facebook we think, but as always, only time will tell.


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February 11Hockey Wins State Championship!
October 29480-382-6641 The Hawk Hotline is available to be used by students who want to report vaping, vandalism, maintenance issues, drugs, bullying, etc., anonymously. 480-382-6641 Help make our school better by being part of the solution.
October 5Boys Bathrooms Shutdown Due to Vandalism by Students and Vaping After Fall Break
Talon Yearbook
Highland Sun
The Student News Site of Highland High School
The Sensation of Autism
Used with permission from Wikimedia Commons
Piper Flood, Staff
There are a lot of kids here like me that are part of the autism spectrum and from what I learned while trekking through my life experience with the disorder, Autism Awareness needs to be better understood and more supported in this school. It's one of the million things that gets stuck in my head, though when I observe the kids at Highland High School and at Highland Junior, despite my uneducated way of reading feelings, I come across the one simple thing that "most" of the students attending the school have not seemed to comprehend; "Autism, what even is that?"
Autism affects the brain of an individual who's born with it, which spawns difficult challenges towards that person of how they interact, feel, and etc. For me, I struggle with many of those predicaments such as making friends, sharing my feelings, understanding people's emotions, and more. Many "normal" kids may think that dealing with Autism is simple, but it's not. It only takes a lot of practice for those who have it to be able to interact when stepping into the real world. I've recently searched the accurate understanding of this disorder from autismspeaks.org as it states in the very first paragraph, "Autism, or autism spectrum disorder (ASD), refers to a broad range of conditions characterized by challenges with social skills, repetitive behaviors, speech and nonverbal communication. According to the Centers for Disease Control, autism affects an estimated 1 in 59 children in the United States today."
The awareness of Autism has grown worldwide in recent years and is internationally recognized every year on April 2nd, in which, all the people wear blue to spread care and support of those who are in the spectrum. However, unlike the odds, Autistic people can turn out to be very unique in most things that come from their interests. They can picture tons of things through their intelligent brains and eventually have the opportunity to become something big like Temple Grandin, an American Professor who was one of the first Autistic individuals to ever become famous of her work. If you ever find someone who is diagnosed with Autism, don't be afraid to become a special friend to them because they may have the same interests as you.
Disney + Yes or No?
Yes, Love It!
No, Seen It...
Highland High School 45 - Desert Vista 27
Highland High School 70 - Boulder Creek 20
Highland High School 49 - Hamilton 28
Highland High School 45 - Alhambra 7
What We Learned As Freshman
Remembering Elise
Sk8 Club
Wishes for Teachers
Seminary on Campus
Success "Blum"s at Highland
What is EVIT?


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The October 1, 2002, National Intelligence Estimate (NIE) was produced by the CIA in three weeks, as opposed to the usual six to 10 months. Regarding the short-notice, request, then-CIA Director George Tenet wrote: "I reluctantly agreed and, on September 12, 2002, directed the National Intelligence Council staff to initiate a crash project to produce an NIE on the 'status of and outlook for Iraq's weapons of mass destruction programs.' The NIE was to answer two key questions on nuclear weapons: Did Saddam have them, and if not, when could he get them? …Had we started the process sooner, I am confident we would have done a better job highlighting what we did and didn't know about Saddam's WMD programs. …The flawed analysis that was compiled in the NIE provided some of the material for [Secretary of State] Colin Powell's February 5, 2003 UN speech, which helped galvanize public support for the war."
– George Tenet with Bill Harlow, At the Center of the Storm, Pages 322-323


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News / Economy / Editor's Choice
Iran team in Syria for 'transformation' in post-war ties
Monday, 13 August 2018 7:39 AM [ Last Update: Monday, 13 August 2018 9:06 AM ]
Syrian officials receive an Iranian economic delegation in Damascus on August 12, 2018. (Photo by IRNA)
An Iranian delegation has traveled to Syria to pave the way for a post-war "transformation" in their economic ties, Iran's official IRNA news agency reports.
Experts from several Iranian ministries were holding talks with Syrian authorities on Monday to finalize a series of agreements signed before, including during a May visit to Damascus by Iran's Minister of Roads and Urban Development Abbas Akhoundi.
"Members of the delegation will be drawing up long-term agreements in the field of economic cooperation to begin a new transformation in the Iranian and Syrian economy during the post-crisis period," IRNA said.
Top on the agenda of the negotiations was banking and customs cooperation in order to boost trade between Iran and Syria, the report said.
The two sides were also to discuss and sign initial agreements on industrial and information technology cooperation, creation of small enterprises, study of water supply networks, establishment of new electricity transmission posts and reconstruction of Syria.
"The focus of the meeting is to make necessary arrangements for the meeting of the High Commission for Economic Affairs, which will be held in the coming days with the participation of senior Iranian and Syrian officials to finalize the contracts," IRNA said.
PressTV-Iran-Syria economic ties key to confronting West: Assad
The Syrian president says enhanced economic cooperation with Iran is one of the most important ways to confront Western plots.
According to the news agency, the two sides were examining each other's capacities in various fields in order to chart out their next steps toward complementing their economic relations.
The meeting of the High Commission for Economic Affairs will be headed by Syrian Prime Minister Imad Khamis and Iran's First Vice President Es'haq Jahangiri and will see the two sides sign a number of documents, including a "strategic document" for economic and cultural cooperation.
Iranian President Hassan Rouhani expressed in a letter to Syrian President Bashar Assad in April his country's willingness to aid in the post-war reconstruction of Syria.
"Just as it stood by the Syrian people in their fight against terrorism, the government of the Islamic Republic of Iran is ready to stand by you in Syria's reconstruction employing all it has in power," Rouhani said.
In December 2017, Iranian companies were tasked with spearheading reconstruction efforts, including rebuilding the country's electric grid and constructing an oil refinery.
Earlier the same year, Tehran signed deals worth "several hundred million euros" with Damascus to repair Syria's power grid in the Aleppo city and the provinces of Latakia and Dayr al-Zawr.
PressTV-With war over, life trickles back into Syria's Harasta
The Syrian government has undertaken a fast-paced and determined reconstruction push in the city of Harasta in the capital Damascus' suburbs which was in the hands of the terrorists for the past few years.
President Bashar Assad has called rebuilding of Syria his "top priority" but stressed that the West "won't be part of reconstruction in Syria, because very simply we won't allow them to be part of it, whether they come with money or not."
Iran Syria economy
MORE FROM Economy
Iran blames botulism for death of migratory birds
Russia's envoy to Israel defends Iran's mission in Syria
Iran, Russia to continue to protect Syria: Official
Iran pledges to contribute to Syria reconstruction


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Watch: Indian Contingent at Tokyo Paralympics Opening Ceremony
India have send 54 athletes to the Tokyo Paralympics.
Published: 24 Aug 2021, 5:13 PM IST
The Indian Paralympic contingent had to make changes at the eleventh hour before the opening ceremony as flag-bearer Mariyappan Thangavelu was among the Indians who were forced to go into quarantine after a co-passenger on their flight to Tokyo has tested positive.
India, who were supposed to have 11 participants in the opening ceremony, participated with discus thrower Vinod Kumar, javelin thrower Tek Chand and powerlifters Jaideep and Sakina Khatun included in the list.
Tek Chand was India's flag bearer at the ceremony.
Tokyo Paralympics 2020: Six Big Indian Athletes to Watch Out For
Devendra Jhajharia - From Winning With Bamboo Javelin to World Domination
India have sent their largest ever contingent with 54 athletes taking part across 9 sports.
For India, who had their best campaign in Rio in 2016, finishing with 2 Gold medals, a Silver and a Bronze, the aim will be to match highs of the recently concluded Olympic Games when they had their best campaign with 7 medals.
India had previously won four medals in 1984 in New York, but none were Golds.
In all, India have won 12 medals at the Paralympic Games – four golds and as many silver and bronze medals in 11 appearances at the Games and Deepa Malik is the only female athlete to win a Paralympic medal. She finished with silver in the shot put F53 event at Rio with a throw of 4.61m.


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OCR Reduces Annual Penalty Caps For Certain Violations Under HIPAA
By Lynda M. Johnson, Timothy C. Ezell and Amie K. Alexander Published in Arkansas Medical News (September/October) On April 30, 2019, the U.S. Department of Health and Human Services (HHS)'s Office for Civil Rights (OCR) issued notification that it is lowering the maximum total penalties it may assess against covered entities and business associates for multiple violations of HIPAA Privacy, Security, Breach Notification and Enforcement Rules in a single year.
Part 8: Discovery Basics
Part 7: Subpoenas and HIPAA
Office For Civil Rights Offers Clarification Of Direct Liability for Business Associates Under HIPAA
By Lynda M. Johnson, Timothy C. Ezell and Amie K. Alexander Published in Arkansas Medical News (July/August) On May 24, 2019, the U.S. Department of Health and Human Services (HHS) Office for Civil Rights (OCR) issued clarification on all instances through which a business associate can be held directly liable for compliance with certain requirements of the HIPAA Privacy, Security, Breach Notification and Enforcement Rules (HIPAA Rules).
Part 6: You Received a Subpoena - Now What?
New Rule Strengthens Conscience Protections For Healthcare Providers and Workers
By Lynda M. Johnson, Timothy C. Ezell and Amie K. Alexander Published in Arkansas Medical News (May/June) The U.S. Department of Health and Human Services (HHS) recently announced its Final Conscience Regulation which broadens protections for individuals and healthcare entities that refuse to perform, assist in the performance of, or undergo certain healthcare services or research activities to which they may object for religious, moral, ethical or other reasons.
Part 5: Damages