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Twitter Party For Peekaboo! and Sophie la girafe iPad Launch
September 23, 2013 | by Hauman Chow
In Events, News
#FamLoopDK Twitter Party
� � Let's celebrate our two newest FamLoop family members: Peekaboo! and Sophie la girafe, with a Twitter party! We will be chatting, giving away prizes and introducing you to the hottest interactive storybook/app for toddlers on the market. Make sure that you download during the promotion period and let your little ones experience them for free. Then join us on Twitter tomorrow night to give us your feedback, thoughts and ask any questions that you may have. You will also be eligible to win prizes during the party. We are giving away six prize packs which include sets of DK books and a total of four iTunes gift cards ranging from $10-$50.
�How do I enter?
Sign in to your Twitter account. If you do not have�an account, visit www.twitter.com to create one. Twitter accounts are�free.
Once logged into your Twitter account, follow the�links and instructions to become a follower of @TechSavvyMama and @FamLoop.
Use the designated party hashtag #FamLoopDK to follow the conversation, talk to us and answer questions that we give during the allotted party time referenced above.
Prizes will be drawn throughout the Twitter party, between the time of 8:00�pm � 9:00 pm ET. Throughout the party we will randomly select via Random.org six winners for�the following six prizes, with the grand prize winner selected at 9:00 pm ET� to close the party. The prizes awarded to random winners are:
Two (2) First Prizes. Set of five (5) Peekaboo! or Sophie la girafe board books.
Two (2) Second Prizes: Set of five (5) Peekaboo! or Sohpie la girafe board books and a $10 iTunes gift card.
One (1) Third Prize: Set of five (5) Peekaboo! or Sohpie la girafe board books and a $25 iTunes gift card.
One (1) Grand Prize. Set of five (5) Peekaboo! or Sohpie la girafe board books and a $50 iTunes gift card.
FAMLOOP/DK TWITTER PARTY SWEEPSTAKES OFFICIAL RULES NO PURCHASE NECESSARY.
A PURCHASE DOES NOT INCREASE YOUR CHANCES OF WINNING. COMMON TERMS USED IN THESE RULES: These are the official rules that govern how FamLoop/DK Twitter Party sweepstakes promotion will operate. This promotion will be simply referred to as the �Sweepstakes� throughout the rest of these rules. In these rules, �we,� �our,� and �us� refer to FamLoop LTD/DK, the sponsor of the Sweepstakes. �You� refers to an eligible Sweepstakes entrant. WHAT ARE THE START AND END DATES? This Sweepstakes starts at 8:00 pm Eastern Time (ET) on September 24, 2013 and ends at 9:00 pm ET on September 24, 2013. (�Entry Period�). The Entry Period will consist of five (5) prizes and one (1) grand prize during the Twitter party period. You must enter each prize period separately. Entries will not carryover or accumulate toward future prize periods. CAN I ENTER? You are eligible to enter this Sweepstakes if you meet the following requirements at time of entry: � You are a legal resident of the 50 United States and District of Columbia, and are 18 years of age or older. � If you are 18 years of age or older, but are considered a minor in your place of residence, you should ask your parent�s or legal guardian�s permission prior to submitting an entry into this Sweepstakes; and � You are registered on http://twitter.com and follow the updates of http://twitter.com/TechSavvyMama and http://twitter.com/famloop by subscribing to follow the accounts� Twitter handle as a follower; and � You are NOT an employee of FamLoop LTD/DK or its affiliates; and � You are NOT involved in any part of the administration and execution of this Sweepstakes; and � You are NOT an immediate family (parent, sibling, spouse, child) or household member of a FamLoop/DK employee, an employee of a FamLoop/DK affiliate, or a person involved in any part of the administration and execution of this Sweepstakes. This Sweepstakes is void outside of the geographic area described above and wherever else prohibited by law. *Twitter, Inc. is not a sponsor of this Sweepstakes and does not endorse or otherwise have anything to do with this event.
Jennifer Essad
can't wait to join in the fun
@MamaBananasAdv rsvp
© DryThemes - Built with love and passion
займы на карту круглосуточно


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UNESCO proposes concrete projects to implement inter-Korean reconciliation
An article from UNESCO
The Director-General of UNESCO, Audrey Azoulay, today met Moon Jae-in, President of the Republic of Korea, for the first time, and expressed the Organization's determination to bolster cooperation with the Korean Peninsula.
"UNESCO wishes to commit its support to inter-Korean reconciliation through concrete projects," declared the Director-General. "We can help restore the links between peoples through shared heritage, educational programmes and cooperation in natural resources management. Facilitating, even accelerating, the construction of durable peace in the Korean Peninsula through culture, education and the sciences is both the ambition and core mandate of UNESCO."
Can Korea be reunified in peace?
To that end, UNESCO intends to focus on projects that are at once concrete and symbolic. In her talk with the President of the Republic of Korea, the Director-General spoke of her will to reinforce cooperation in the three area of cultural heritage, education and science. These proposals will be discussed with the authorities of the Democratic People's Republic of Korea.
With regard to cultural heritage, discussions are expected to concern cooperation with a view to identifying shared nominations for inscription on the World Heritage List and on UNESCO's lists of Intangible Cultural Heritage. Work will also be undertaken to publish a first dictionary of Korean etymology.
In education, UNESCO will lend its support to teachers by reinforcing global citizenship education. Educational programmes to be implemented across the Peninsula could also be developed.
Finally, Ms Azoulay and President Moon Jae-in also envisaged scientific cooperation with regard to water and environmental preservation. Discussions notably focused on initiatives that could be implemented to facilitate joint access, sharing and management of transboundary water resources, and the preservation of biodiversity and its sustainable use for the benefit of local communities.
November 20, 2018 DISARMAMENT & SECURITY, East Asia, United NationsEast Asia, United NationsCPNN Coordinator
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redpajama_set_name: RedPajamaCommonCrawl


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COVID-19: Lowe's Canada's response to the pandemic. Read more
Our affiliated dealers
Reno-Depot
Dick's Lumber
Outstanding Retailer Awards: Lowe's Canada pulls off a hat trick with 3 winners
Best Large Surface Retailer - Lowe's Barrie (ON)
Best Building Supply/Home Centre (< 15,000 s.f.) - Ace Matériaux Armand Dumaresq (QC)
Contractor Specialist - RONA Penticton (BC)
Boucherville, Québec – November 15, 2017 – Lowe's Canada is proud to celebrate the achievement of three of its stores at the Hardlines Outstanding Retailer Awards which took place on Tuesday, November 14 in Niagara Falls. Three of Lowe's Canada's banners, namely Lowe's, Ace and RONA, have taken home awards in the following categories: Best Large Surface Retailer - Lowe's Barrie (ON); Best Building Supply/Home Centre (< 15,000 s.f.) - Ace Matériaux Armand Dumaresq (QC) and Contractor Specialist - RONA Penticton (BC).
"Thanks to its multi-banner, multi-format network of stores, Lowe's Canada is ideally positioned to meet the needs of today's various consumers segments, from DIYers to pros and contractors, no matter their type of home improvement project, and no matter where they live," mentioned Sylvain Prud'homme, President and CEO of Lowe's Canada. "These awards attest once again of the diversity of our vast network and of the strength of our business model. I wish to extend our most sincere congratulations to the awardees and their entire teams who work hard, day after day, to offer the best shopping experience to our customers."
Best Large Surface Retailer - Lowe's Barrie (ON)
The Lowe's in Barrie opened its doors nine years ago with the purpose that sets the Lowe's banner apart: "To help people love where they live." With a team of 155 employees, customer focus has translated into an increase in customer count exceeding 8% in 2017 (year to date), and sales growth trending consistently above 10% for the last four years. The team's engagement in showing the value it offers, from merchandise presentation standards to process and procedure, is key in explaining this success. If marketing brings customers in, the in-store experience (service, in stock, cleanliness, knowledge, etc.) turns them into loyal customers. The Lowe's Barrie store is also very active in the community. Recent initiatives include collaborations with the Women's Shelter in Barrie and Habitat for Humanity in Huronia, food drives for the Barrie Food Bank, and various toy drives.
Guy Samson purchased Ace Matériaux Armand Dumaresq in Rivière-au-Renard in July 2014. Previously family-owned, the business started up as a saw mill and eventually included a hardware store that was founded about 25 years ago. When he bought the company in 2014, Mr. Samson was facing several challenges: saturated market shares, a competitive environment that included three other hardware stores in his territory, decreasing demographic rate and high unemployment rate. To gain market shares, he chose to rely on a very strong customer service approach. Many SKUs were added to the inventory, the warehouse was expanded by 4,500 sq. ft. and the store by 1,200 sq. ft. This new approach was a huge success: the store increased it sales by more than 400% in just 27 months of operation.
In 2005, the Mielke family created a joint venture with RONA to open RONA Penticton in the heart of the Okanagan Valley. The store customer base is a 50-50 retail-contractor split. In 2016, the store expanded its EWP yard and garden centre, moved the door and countertop shop into a new facility, expanded the Penticton Contractor Desk and opened a new satellite Contractor First location in Osoyoos. This 2,000 sq. ft satellite store with two acres and a staff of 11 allowed RONA Penticton to expand in the South Okanagan and have the Penticton store focus on sales closer to home. As a result, both locations are thriving and in ratio to the size of its operation, Osoyoos is one of the highest performer nationwide within RONA.
About the Outstanding Retailer Awards
Launched in 1992, the Outstanding Retailer Awards are the industry's only national awards program dedicated to celebrating the achievements of hardware and building supply dealers in Canada. In its 25-year history, the program has honoured more than 150 retailers. The 2017 awards were presented at a special ORA Gala Dinner organized as part of the Hardlines Annual Conference, held November 14, at the Sheraton on the Falls in Niagara Falls.
About Lowe's Canada
Lowe's Companies, Inc. (NYSE: LOW) is a FORTUNE® 50 home improvement company serving more than 17 million customers a week in the United States, Canada and Mexico. With fiscal year 2016 sales of $65.0 billion, Lowe's and its related businesses operate or service more than 2,370 home improvement and hardware stores and employ over 290,000 people. Based in Boucherville, Quebec, Lowe's Canadian business, together with its wholly owned subsidiary, RONA inc., operates or services more than 600 corporate and independent affiliate dealer stores in a number of complementary formats under different banners. These include Lowe's, RONA, Réno-Dépôt, Marcil, Dick's Lumber and Ace. In Canada, the companies have more than 25,000 employees, in addition to nearly 5,000 employees in the stores of RONA's independent affiliate dealers.
514 599-5900, ext. 5271
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See Lowe's Companies, Inc. website
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How To Cook Bluefin Tuna Collar?
Tuna / By The VeryMeaty Team
For tuna that is just done, place the tuna collar in the oven and bake for 20 minutes. If slightly pink tuna makes you uncomfortable, you might…
Grilling Fish Collars
Generally speaking, buying fish collars will be the most difficult part; you'll need to go for a reputable fishmonger, and calling beforehand is a wise approach. To put it simply, you want them to take the head of a bigger fish, like salmon or hamachi, and chop off everything from the gill plate to the mouth, leaving you with two obliquely "T"-shaped pieces.
There are countless options when it comes to seasoning. They are delectable with only salt, pepper, and oil, but London claims that a Japanese tare elevates them to a higher level. "Halfway through the cooking process, you may start brushing that on your collar to create a lovely, sticky, tasty glaze with a strong umami flavor. It has body because of the sugar in the mirin." All things considered, London wholeheartedly supports both the high and the low in terms of embellishing the goods: "I mean, man, I'd eat a fish collar with barbecue sauce for f*&%! Though I've never done it before, it currently sounds quite nice to me."
Additionally, this sauce goes exceptionally well with grilled chicken thighs and wings and anything else that resembles some yakitori. For the same result that it had on these fish collars, brush some on after the fat has partially rendered.
Collars are actually very forgiving when it comes to cooking since all that fatty, gelatinous goodness will keep them from drying out. You want low, consistent heat whether you're cooking in an oven or on a grill. London notes that you want the skin to cook evenly, the bones to release their juices, and all of the tiny pieces of meat to have a chance to cook. He suggests inserting a metal fork or small knife into the thickest portion of the collar, letting it sit for 20 seconds, and then touching it to your wrist or lip to determine when they are finished. Damn that's hot is a sign that something is finished, according to London. (For the record, a chef has given us some of the best advise ever.)
a grill
Fire up your grill now, around 15 minutes before you plan to cook. Make sure it's heated.
I place the fish skin side down on the grill to cook it after giving it some chance to absorb the seasonings. I'll let heavier cuts sit with the skin side down for around 10 minutes. I'll then exit and quickly flip them over. You should use caution because the skin of the fish is already likely to be flaking off.
I quickly grill the second side, more for grill markings than anything else, though some extra heat is also beneficial. No more than five minutes should be spent with the flesh side down.
How to Get Ready
The 2 tablespoons of water and sugar should be combined in the pot. Stir everything together. Cook the mixture until it turns a light shade of tea over medium heat. As this mixture cooks, don't stir it.
After the mixture turns light brown, remove it from the pan and add 1/4 cup water, 1/4 cup soy sauce, 1/4 cup lime juice, 1/4 cup fish sauce, 1/4 cup white pepper, and 1/4 cup salt. Reserve for the fish collar glaze.
Grill should be heated to medium, about 400–425 degrees. Cook the collar for 12 to 15 minutes, turning it over after 6 minutes to cook it for a further 6 minutes skin side up.
Cook for another 6 to 8 minutes after flipping the collar. Glaze with Vietnamese caramel and flip back over to the skin side. Cook for a further 1-2 minutes, then transfer to a serving dish and garnish with cilantro and seasonal vegetables.
What component of a bluefin tuna is the best?
The most coveted component of bluefin tuna is called otoro. The fattiest section of the fish, it comes from the inside of the belly. The texture is frequently characterized as being extremely rich, marbling, and melting in your tongue. These reasons make it the historically most expensive component of bluefin tuna.
What is the tuna collar?
Ahi tuna collars are the oily, fatty portions of the fish that are located between the head and the body.
Tuna collars are ideal for grilling or smoking; but, as they are an oily component of the fish, they can flip more quickly than other parts if not cooked quickly.
HOW IT COMES: Each tuna collar weighs between 2 and 4 pounds and is delivered intact and undamaged. Not by weight, but by the piece, each collar is sold.
STORING: If you decide to keep your fish in the fridge, we advise eating it three days after delivery. We advise freezing the fish as soon as it is delivered to preserve freshness if you do not intend to consume it within three days. We advise taking the fish out of the bag, giving it a quick rinse under cold water, and patting it dry before freezing. Then, before freezing, put it in a vacuum-sealed bag, an airtight ziplock bag, or double saran wrap. Run cool (not hot) water over the bag for five to ten minutes to help it defrost. The second-best choice is refrigerator defrosting.
SUSTAINABILITY: For additional details on this species' fisheries, please visit NOAA's FishWatch.gov.
NOTES: For delivery purposes, each pound is an estimate only; it is not an exact weight. We try to get it as close to the requested weight as we can. Each cut of fish weighs between one and two pounds, and for the best cut, we advise ordering at least two pounds.
WARNING: Eating raw or undercooked seafood or shellfish may make you more likely to get sick from eating them.
How may tuna steaks be prepared without becoming dry?
Tuna should be cooked very briefly over a high heat in a frying pan, on a griddle, or over a grill; or fried under oil (confit), cooked sous vide, or boiled in a sauce. Tuna dries up rather fast and becomes crumbly. Tuna can be prepared to be served rare or tataki—a Japanese technique where the tuna is cooked to a crust on the outside and raw inside. Controlling this is simpler when pan-frying or griddling.
Because tuna has a pretty strong flavor, adding additional herbs, spices, and flavors is simple and won't overpower the dish's flavor. While marinating tuna steaks will enhance their flavor, they won't get any juicier; the only method to prevent your steak from drying out is to watch it closely as it cooks.
How is a fish collar consumed?
Sean Telo, a chef in Brooklyn, is an expert in reducing food waste. Any menu item with a large, meaty fish collar is one of his favorites. However, you don't have to wait till you're at a restaurant table to sample one; you can easily find one to prepare at home. Request a few from your fishmonger (they aren't typically in the display case), then practice until you master the technique. Impress your guests by serving them as the first or main course at your next gathering.
We were given the good advice to carefully push and prod the meat away from the bone and cartilage with chopsticks. Here is a quick guide to cooking fish collar. Now go look for one!
What makes fish collars so great? They are quite awesome. They serve as the point where all the elements of the fish come together, sort of like the pork shoulder. That's typically where the most flavor resides on any animal. Fish collars, such as the yellowtail collar known as hamachi kama, are quite popular in Japanese cuisine. Using local fish, I also braise it in the Japanese manner. For a very long time, I have been able to find pollack collars, an extremely flavorful unused fish item.
Its difficulty in eating is a contributing factor. Chopsticks are the best method, although it is undoubtedly a little more difficult for folks. With a fork and no fin staring back at you, fish fillets are far more common and simpler to understand. One of my favorite tools to use is a fish collar, but you have to be aware of it. It's unlikely to be your best-selling product.
Salmon and yellowtail collars are excellent. The one to accompany is any large fish. For instance, a John Dory collar would be inappropriate to serve because of its diminutive size.
How would you take the collar off a complete fish if you were disassembling it? You leave the collar on the head and cut it off in one large piece when you make your initial incision behind the head toward the abdomen to obtain the fillet. By doing so, you receive the fish on both sides, which you then chop in half. Actually, removing the collars is a lot of fun.
It need not be the case for all, though. Fish should always be cooked with a "fish tester," which can be anything you can use to pierce the fish when you think it's done. It's still raw if you encounter opposition. The fish collar is first cooked on our Japanese grill before being placed briefly in the wood oven. Alternately, we'll steam it the rest of the way after putting it in a boiling pot with kimchi and fish broth.
What's one tip you may provide a novice home cook for preparing their first fish collar? Fish collar is incredibly excellent, but can easily be overcooked. As a general guideline, if it's your first fish collar, don't worry if it's a touch undercooked. You can always re-bake it, but you can't undo what you've already done. It's best to use fish testers. If you poke it, and it comes out easily and cleanly, it is prepared.
What portion of the tuna is the best?
The section of the fish's belly called otoro is the most coveted. Since it is the fish's fattiest component, it virtually melts in your tongue. By itself, the marbling throughout the steak allows for the differentiation of the underbelly into distinguishable categories. It is amazing if you notice dazzling white lines next to soft pink ones. Otoro has an abundance of mouthwatering oily lines that give it a unique and wonderful flavor. The area from the lower abdomen toward the head is by far the most priceless otoro. The richness and great demand of otoro make it more pricey than other fish portions. Although big eye and yellow tail tuna are both common ingredients in sushi, only bluefin tuna may be used to produce otoro of the highest caliber.
The section of the tuna that is used the most frequently is the akami. This meaty, red portion is typically found on top of rice in sushi rolls or sashimi. It is the leaner meat taken from the fish's flanks. This is the primary component of a tuna, making it considerably more widely accessible than chutoro or otoro.
Another component of the tuna is chatoro. This is the ideal fusion of akami and otoro. It mixes both varieties of tuna and offers a texture that is both meaty and fatty for a mouth-watering experience. However, because it only makes up a small portion of the fish, there isn't much chutoro when eating tuna. Chutoro sashimi is made using an entire fish.
The bluefin tuna, also known as "maguro," which is often rather lean, and the yellowfin tuna, also known as "ahi," which is a fattier species, are typically the two types of tuna that are served in restaurants. The term "maguro" may also refer to yellowfin tuna, however this is less common and usually refers to bluefin tuna. Based on the amount of fat in each subtype, tuna sushi is further divided. You will receive "akami" if you order any type of tuna roll or sushi without asking for "toro" or if you ask for "maguro" in a restaurant.
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Q: URL Mapping works on localhost but not on production server in asp.net I have certain values that are mapped in web.config file for URL Mapping. When i browse for file it works on localhost. But, when i deploy this application on IIS on Production it wont work. shows Error: "404: The resource cannot be found." dont know why?
Any idea?
Web.config markup:
<urlMappings enabled="true">
      <add url="~/Pune" mappedUrl="~/City.aspx?ID=1"/>
</urlMappings>

In .aspx file:
Pune City

After searching i have got some clue that it must be:
<urlMappings enabled="true">
          <add url="~/Pune" mappedUrl="http://mycustomdomain.com/City.aspx?ID=1"/>
</urlMappings>

But, unfortunately this too wont work..!
Anything else..do we need to do settings in IIS or web.config file?

A: To do this just follow steps:
For IIS 7:
open IIS manager , double click on the website , double click Handler Mappings , right click on the specific handler , click Request Restrictions and uncheck the checkbox Invoke handler only if request is mapped to.

A: See this:
http://forums.asp.net/t/1523272.aspx?urlmappings+stopped+when+moved+to+ii7
Url mappings should not be supported in IIS 7 - you should use Url Rewrite module

redpajama_set_name: RedPajamaStackExchange


Airbus has announced its plans to further expand its support operations across Asia, following last week's announcement of a new subsidiary to produce flight operations data in Thailand.
According to Airbus, the new Thai data production center will be based at the company's existing Airbus Group offices in Bangkok, and will recruit local staff "with proven experience in airline flight operations data management" to produce electronic resources for Airbus products.
Airbus said the establishment of the new data center was made considerably easier through the support of the Thai government, with the manufacturer receiving significant help from the Thai Board of Investment (BOI).


Need to make an outstanding RESTAURANT app for Android and iOS?
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Hurry Up! This offer lasts only until 27 OCTOBER when at least 10 BUYERS pre-order it.


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Ржепориє ( — муніципальний і кадастровий район на заході Праги, столиці Чехії. Входить в адміністративний округ Прага 13. З 1974 року є частиною Праги «Прага-Ржепориє». Площа району 9,87 км². Населення 3727 осіб (2011).

Історія
6 травня 1945 року в Ржепориє увійшла 1-а піхотна дивізія Російської визвольної армії (ком. С. К. Буняченко. Увечері 6 травня тут зупинився на нічліг командувач РВА генерал А. А. Власов. Власов і Буняченко прийняли рішення атакувати центр Праги, що зіграло важливу і позитивну роль в Празькому повстанні.

 Пам'ятник РВА

У 2019 історик і депутат від Громадянської демократичної партії Павел Жачек виступив з ініціативою встановлення в Ржепориє пам'ятника бійцям Російської визвольної армії (РВА, «власовці») . Глава (староста) району від Громадянської демократичної партії, журналіст Павел Новотни (Pavel Novotný) виніс ініціативу на розгляд муніципальної ради. 10 грудня 2019 року муніципальна рада одноголосно схвалила цю ініціативу .

У квітні 2020 року за агентурними даними чеської сторони, у Прагу прибув агент неназваної російської спецслужби із завданням убити мера Праги Зденека Гржиба і старост двох районів Праги, включаючи старосту Ржепориє, за допомогою ін'єкції рицину . Обидва старости і мер Праги отримали цілодобову охорону поліції .

Спорт
У 1921 році був заснований футбольний клуб FK Řeporyje. Офіційно клуб був заснований і зареєстрований як Sparta Řeporyje у вересні 1928 року. У 1965—1968 рр. був побудований сучасний стадіон. У 1996—1997 рр. стадіон був реконструйований.

Примітки

 Примітки

 виноски

Література

Історичні райони Праги
Статті з джерелами з Вікіданих

redpajama_set_name: RedPajamaWikipedia


Koichiro Sugimoto, Hiroshi Murata, Hiroyo Hirasawa, Chihiro Mayama, Makoto Aihara, Ryo Asaoka; Combining Optical Coherence Topography measurements using the 'Random Forest' decision tree classifier improves the diagnosis of glaucoma. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4821.
Methods: SD-OCT (Topcon 3D OCT-2000) and perimetry (Humphrey Field Analyzer, SITA standard, 24-2 or 30-2 test pattern) measurements were conducted in 293 eyes of 179 subjects with glaucoma or suspected glaucoma. Visual field (VF) damage was used a 'gold-standard' to classify glaucomatous eyes. VF damage was defined as a pattern standard deviation (PSD) value, or, a Glaucoma Hemifield Test (GHT) result, outside normal limits. In total 224 out of 293 eyes (76.5%) had glaucomatous VF damage. The 'Random Forest' method was then used to analyze the relationship between the presence/absence of glaucomatous VF damage and the following variables: age, gender, right or left eye, plus 238 different OCT measurements (including axial length). The area under the receiver operating characteristic curve (AROC) was then derived using the probability of glaucoma as suggested by the proportion of votes in this Random Forest classifier. For comparison, four AROCs were derived based on individual OCT thickness measurements of: (i) the macular retinal nerve fiber layer (m-RNFL) alone, (ii) the mean circumpapillary retinal nerve fiber layer (cp-RNFL) alone, (iii) the ganglion cell layer + inner plexiform layer (GCL + IPL) alone, and (iv) rim area alone.
Results: The AROC from the combined Random Forest classifier (0.90) was significantly larger than the AROCs based on individual measurements of m-RNFL (0.86), cp-RNFL (0.77), GCL + IPL (0.80), and rim area (0.78).
Conclusions: Evaluating OCT measurements using the Random Forest method provides an accurate diagnosis of glaucoma.


Infinity's Kappa speakers set a new standard in car audio. Patented Plus One™ woofers deliver tight robust bass and high-output that is detailed and musical. Edge-driven textile dome tweeters with oversized voice coils deliver silky smooth highs with increased thermal power handling for high volume enthusiasts.


text:
Los Angeles is a "City on Fire" in Gaby G's new video
Tommy Monroe
Gaby G's latest masterpiece, "City on Fire" is inspired by the celebrity filled, drug-fueled enigma that is Hollywood. She kicks off the song stating, "Hail from MIA / City of Angels where I stay" before walking listeners through the fast life in LA. The single is produced by Zach Fogarty and features rock-influenced instrumentations with traces of electronic sounds in the beat. The official music video is a stunning presentation of a harlequin of colors and LA's signature landscape. It also features a cameo from G's girlfriend Abella Danger who portrays an angelic figure corrupting the singer with the "rockstar" lifestyle one would experience in LA. Towards the end of the video, Danger convinces Gaby to leap over to the dark side of Hollywood.
https://youtu.be/BXomZ3JZRnI
Speaking on the video, Gaby G said: "Who doesn't love a juicy dark metaphor? We froze our asses off at the top of the hill. We had to catch the perfect 'Magic Hour' lighting so we had to shoot in the exact hour the sunset occurs when the lighting is best to get the right colors. I came prepared with 3 joints to light for the smoking shots and forgot a damn lighter! That's why I'm hitting a juul. I thought it was still fitting since everyone in LA has one."
As simple as the concept of the video is, viewers can easily understand the theme of the song through it. The Miami-bred singer has been on a roll since the release of her debut EP (Polarized) in 2016. Since then, she has attracted loyal listeners with tracks like: "Closer", "Numb", "Say My Name", and "Understatement".
Connect with Gaby G: Twitter Instagram
Gaby G
Tommy Monroe is a music journalist, curator, and brand strategist. His words on Hip-hop, R&B, EDM, Alternative music, and the music industry have been featured in various music publications. @Tommyivl
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NDP leadership race expands with Charlie Angus entering the fold
MP Angus enters NDP leadership race
OTTAWA — And then there were two.
Ontario MP Charlie Angus officially entered the NDP leadership race Sunday — a competition that's expected to start heating up soon with a debate scheduled for next month in Ottawa.
In an interview with The Canadian Press, Angus said the New Democrat race will be about renewing the NDP — a party that is struggling to rebuild after being reduced to third-party status in a devastating election loss in 2015.
"If there is one thing I am going to commit to during this process, it's to try and build that relationship of getting out, of meeting people, of getting people to re-engage," he said.
Angus, a northern Ontario MP first elected in 2004, said his politics have always been rooted at the community level, and that he tries to speak truth to power in a clear way.
"That's how you excite people that's how you sign up members," he said. "That's how you get people to donate."
With its coffers drained, one of the party's biggest challenges will be to restore its fundraising capacity ahead of the next vote in 2019. It will also need to win back the support of progressives who voted Liberal in the last election.
Angus said Prime Minister Justin Trudeau doesn't have the same understanding of the 'middle class' that he does, adding both Liberal and Conservative governments have contributed to its erosion over 25 years.
"I still know people who are trying to get by on $12 an hour and can't feed their families," Angus said.
"I know what they are going through; I can feel it and I can articulate it. I don't know if the prime minister knows those people because it is doesn't seem it is reflected in the policies he brings forward."
Angus, a former musician and father of three girls, freely admits he never thought he would be a politician. He avoids "fancy functions" in Ottawa as a rule because he's never found much point in attending.
"I am always focused on the people I represent," he said.
"Does that make me an outsider? I don't know. I think it just makes me still rooted in the communities I come from and our politics need to be rooted in communities if we are going to offer Canadians something real in Ottawa.
"I come from a real place, I speak about real issues and I stay out of all the silly stuff."
Angus, well-known for his advocacy on indigenous issues, made the announcement Sunday to coincide with the anniversary of a motion he introduced in the House of Commons in 2012 over equitable access to education for aboriginal children.
The motion was named after Shannen Koostachin, a teenager from the northern Ontario First Nation of Attawapiskat who advocated for First Nations schools and died in a car accident in 2010.
Angus decided to launch his campaign at the Horseshoe Tavern in downtown Toronto — a place where he says he has deep roots because of his musical background.
"The very first punk show I ever saw was here when I was 15 years old," Angus told the crowd. "My first political lessons were with a punk band."
He said those lessons have stuck with him. At one point during his speech he took some time to acknowledge his new suit.
"I just bought this suit," Angus told his amused audience. "It cost me 160 bucks. I spent the money because we're going to bring a little bit of class back to politics."
Many of his supporters say they hope he can bring the party back to its core values.
"I had so much hope for (outgoing NDP leader Tom) Mulcair," said Margarita Ramon, 58, who came to see Angus speak. But she said she feels Mulcair moved the NDP too far toward centrist policies in the leadup to the 2015 federal election.
"I was very disappointed," she said.
B.C. MP Peter Julian is also a registered candidate in the race to replace Mulcair at the helm of the NDP.
Quebec MP Guy Caron is expected to enter the competition on Monday, while Manitoba MP Niki Ashton and deputy Ontario NDP leader Jagmeet Singh are also considering bids.
The first leadership debate will be held in Ottawa on March 12 and voting is scheduled for October.
With files from Maija Kappler in Toronto
—Follow @kkirkup on Twitter
Kristy Kirkup, The Canadian Press
Under coach Marty Calder, Brock University wrestlers add to medal haul
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Home » Uncategorized » CRISPR DNA editing system controlled by light
CRISPR DNA editing system controlled by light
April 7, 2017 July 19, 2015 by Brian Wang
Japanese researchers led by University of Tokyo chemist Moritoshi Sato have refined the CRISPR-Cas9 method by developing alight-activated Cas9 nuclease, a technological advancement that significantly improves scientists' ability to hone in on target genes for research. Converging these two methods brings specificity on a new level, making for increased spatial and temporal control over the system. Essentially providing scientists with an on/off switch for genes, this new method brings unprecedented precision to gene editing, something scientists have been seeking for. Scientists involved in the research engineered photoreceptors that developed pairs of photo switches called Magnets. These magnets were specifically designed to recognize each other based on electrostatic interactions. These interactions can be activated by light, thereby providing a way to analyze specific genes without activating or inactivating unnecessary DNA components. With these Magnets, Sato's team was able to engineer a photoactivatable Cas9 nuclease (paCas9) for light-controlled genome editing.
The issue with the current version of the Cas9 nuclease is that it does not allow scientists to hone in on specific cells in specific areas. Difficult to control, the CRISPR-Cas9 system sans Optogenetics was not the most effective way for researchers to learn about the genome. In order to create this new, innovative method, Sato and his team split the Cas9 protein in half, inactivating it and pairing each half with a Magnet. When activated by blue light, the Magnets came together, pushing both halves of the Cas9 nuclease together. Now active, the new complex is now light activated and can turn on and off in the presence or absence of this blue light. Working to expand the colors of light compatible with the system, Sato and his team are working to continue to make genome editing more flexible.
Nature Biotechnology – Photoactivatable CRISPR-Cas9 for optogenetic genome editing
"The [new] study makes use of the split Cas9 architecture to enable light-activated genome editing," postdoc Fei Ann Ran of Feng Zhang's lab at the Broad Institute wrote in an e-mail. "It's a nice demonstration of using the structural knowledge of Cas9 to engineer it for expanded capabilities, and highlights the versatility of the system."
"My impression is that the light-activated system using the magnet approach works well, and some researchers are likely to find it useful for specific applications," Knoepfler said. "For instance, there may be specific developmental studies where ultra-precise activation of gene editing such as in a specific developmental domain via a precisely directed beam of light could prove to be a very elegant approach." He added that it's not yet clear if the system will be effective in reducing the off-target effects of CRISPR, but that any technology that limits the time during which the gene-editing components are active will likely do so.
Sato's group now plans to expand the colors of light that can activate the paCas9 nuclease "to make genome editing more flexible," he said. "For this purpose, development of new photoswitching proteins with color variation appears to be a key element."
They describe an engineered photoactivatable Cas9 (paCas9) that enables optogenetic control of CRISPR-Cas9 genome editing in human cells. paCas9 consists of split Cas9 fragments and photoinducible dimerization domains named Magnets. In response to blue light irradiation, paCas9 expressed in human embryonic kidney 293T cells induces targeted genome sequence modifications through both nonhomologous end joining and homology-directed repair pathways. Genome editing activity can be switched off simply by extinguishing the light. We also demonstrate activation of paCas9 in spatial patterns determined by the sites of irradiation. Optogenetic control of targeted genome editing should facilitate improved understanding of complex gene networks and could prove useful in biomedical applications.
SOURCES – Nature Biotechnology, The Scientist
Categories Uncategorized Tags physics, quantum computer, qubits, science Post navigation
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Memcomputing NP-complete problems in polynomial time using polynomial resources and collective states


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WASP-32 eller Parumleo, är en ensam stjärna i den södra delen av stjärnbilden Fiskarna. Den har en skenbar magnitud av ca 11,26 och kräver ett teleskop för att kunna observeras. Baserat på parallax enligt Gaia Data Release 2 på ca 3,6 mas, beräknas den befinna sig på ett avstånd på ca 910 ljusår (ca 278 parsek) från solen. Den rör sig bort från solen med en heliocentrisk radialhastighet på ca 18 km/s.

Nomenklatur
WASP-32 har på förslag Singapore fått namnet Parumleo. Namnet valdes i NameExoWorlds-kampanjen under IAU:s 100-årsjubileum i januari 2020. En tillhörande planet har fått namnet Viculus.

Egenskaper
WASP-32 är en gul till vit stjärna i huvudserien av spektralklass G0 V, som är relativt utarmad på litium, vilket är vanligt för massiva stjärnor som hyser heta Jupiterplaneter. Den har en massa som är ca 1,1 solmassa, en radie som är ca 1,1 solradie och har ca 1,5 gånger solens utstrålning av energi från dess fotosfär vid en effektiv temperatur av ca 6 100 K.

Planetsystem
Exoplaneten WASP-32 b, senare kallad Viculus, av typen "het Jupiter" upptäcktes 2010 vid WASP-32. Den befanns 2014 kretsa kring värdstjärnan i prograd riktning.

Uppföljningsstudier som använder analys av transittidsvariation har inte lyckats hitta någon, och har därför 2015 uteslutit förekomsten av andra massiva planeter vid WASP-32.

Se även
 Lista över exoplaneter

Referenser

Noter

Externa länkar
 https://www.universeguide.com/star/122453/wasp32

Stjärnbilden Fiskarna
Huvudseriestjärnor klass G
Solsystem
Solliknande stjärnor


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Find out more about Master of Science in Biology / Education
Home Online Degrees Master of Science in Biology / Education
Degree: Master of Science in Biology / Education
School: Grand Canyon University
Grand Canyon University's Master of Science in Biology with an Emphasis in Education degree program provides the opportunity for students with a background in biology to pursue a career in education. This graduate biology education program prepares students to teach biology in undergraduate courses at a two-year or four-year institution in both campus and online modalities.
Students will engage in a curriculum that balances biology content with pedagogy and classroom techniques. By pursuing this career pathway, students will adopt best teaching practices, analyze current research, learn to communicate complex topics and ideas and explore graduate-level biology concepts within the context of real-world examples. Students will engage in a curriculum that balances biology content with pedagogy and classroom techniques. By pursuing this career pathway, students will adopt best teaching practices, analyze current research, learn to communicate complex topics and ideas and explore graduate-level biology concepts within the context of real-world examples.
Grand Canyon University is accredited by:
Grand Canyon University is accredited by the Higher Learning Commission (hlcommission.org), an institutional accreditation agency recognized by the U.S. Department of Education.
Grand Canyon University © 2020– All Rights Reserved. For the most up-to-date information about admission requirements, tuition, scholarships and more, visit gcu.edu. Please note, not all GCU programs are available in all states and in all learning modalities. Program availability is contingent on student enrollment. GCU, while reserving its lawful rights in light of its Christian mission, is committed to maintaining an academic environment that is free from unlawful discrimination. Further detail on GCU's Non-Discrimination policies can be found at gcu.edu/titleIX.


Online Shopping is rather the craze nowadays. We buy every little thing from food to electronic devices online what does bomo mean. When it comes to purchasing an item like a mattress that we are also made use of to going to the shop as well as buy, we often tend to be hesitant what does bomo mean occasionally. This can be somewhat justified considering that a bed mattress is a rather a significant buy and also returning such a product can be a hassle if you occur to make an error with your choice. Below are some of the points that you require to understand prior to you buy mattress online.
Are you looking for mattress sales to give your bed a new life? Well, the bed mattress sector is everything about simple points stood for in quite what does bomo meanchallenging way. It is good to understand that mattress sales are getting much more as well as more frequent. Some of the leading makers supply periodic deals on normal as well as restricted time products. These mattress sales are ideal for everybody. For vendors, these sales bring a whole lot of marketing and some quick capital. Whereas in customer's perspective – mattress sales feature unequaled financial savings and customers seeking spending plan products also, sometimes discover it feasible to earn a better and high quality purchase. Being a customer and also especially the one that is out on a very essential objective of purchasing a cushion what does bomo mean – you ought to keep on your own stick with some principals. Always, believe before you click the "order" button as today' s advertising and marketing strategies are kind of traps. Following are a couple of, general standards for people that will purchase bed linens products.
In our view, it is not a good idea to wind up with a substandard acquisition for conserving some dollars. Nevertheless, numerous research study' s have actually currently ended that sleep is extremely important to our physical and mental wellness and wellness. Thus, you have to be really careful while purchasing anything from mattress sales. Fortunately talking, there is no rocket scientific research involved in any way. Keep yourself stick with the trusted suppliers either online or on the traditional market, and that's all. Trusted names normally don't place their name and also organisation at danger for yielding more by selling inadequate or out-of-date items.
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The memory foam cushion comes on the leading as they are the most preferred ones. These cushions provide a lengthy lifespan, they are available at an affordable price, and their toughness ratings are way much better than their equivalents. You could call it either innerspring mattress or springtime bed mattress straight.
Since you recognize buying a mattress online will not make you be sorry for at the end, allow's see the important things you could do it make your choice as much better as feasible. To begin with, it is extremely crucial that you are clearly conscious of the type of item you are seeking. Everyone has their own style of sleeping. There are cushions which are much better for back sleepers than side sleepers. Then there are some which would certainly treat somebody with a rigid back better. Know specifically just what you are choosing, as well as after that begin surfing for the bed mattress that would certainly match all your demands. Otherwise, you are most likely to obtain sidetracked by all the choices you will see and also finish up getting something that clearly does not match you, your demands or your way of living.
As discussed above as well, among the largest benefits of on the internet buying is the access to thousands of individual testimonials. If the individuals are confirmed, the chances are that they would certainly discuss more the weak points of an item that its assets– this is natural for us people and also it great for you as a brand-new purchaser to remove the items that do not suit you. Review at least 20 reviews by previous users before you make the decision. The more reviews you can check out the far better. There are rare possibilities that an item is a great deal better than what it has been described by the users, however the majority of the moment if the testimonials are trustworthy, it would certainly provide you a great understanding into the experience of utilizing the mattress that you could not obtain from anywhere else.


Alan started his career at Heerema Fabrication Group in the position of Construction Manager at Heerema Hartlepool in 2009 and subsequently moved into the position of Yard Manager in 2011. As per October 2013 Alan was promoted to Yard Director of Heerema Hartlepool.
Prior joining Heerema Fabrication Group, Alan completed a time served apprenticeship in Engineering, and quickly progressed through the ranks to Superintendent, and Piping Engineer both onshore and offshore at THC and HMC offshore. In 1993, he became General Manager at Cordell Group.
Alan graduated at Hartlepool College (ONC/HNC) followed by an ILM diploma with the Institute of Leadership and Management.


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Learn How to Build a Solar Lamp with The Coffee Bean & Tea Leaf
I am always proud at how - the first company who trusted my skills, talent and capabilities - continues to serve great cups of coffee (and tea!) and serve the community.
The Coffee Bean & Tea Leaf®, through its Caring Cup program, is supporting the United Nations' 7th goal for sustainable development: AFFORDABLE AND CLEAN ENERGY. It is a sad reality that a great number of communities in the Philippines still continue to live without electricity in their homes, one of the most basic necessities for decent living conditions,
The Coffee Bean & Tea Leaf® is hoping to do its part to respond to the need by giving the gift of light through its partnership with My Shelter Foundation for its Liter of Light project.
The Liter of Light (or Isang Litrong Liwanag) project is an initiative that brings solar lamps to communities that lack electricity. Recent developments have enabled My Shelter Foundation to convert common kerosene lamps into a medium that gives people access to sustainable light. Kerosene lamps are one of the cheapest light devices in energy poor areas, yet the downside is that they let out toxic smoke harmful to the health of individuals. Through the Liter of Light project, the kerosene lamps are made clean, becoming a source of light that does not give off harmful fumes through a combination of a simple circuit, LED, solar panel, and battery.
On April 23rd, The Coffee Bean and & Tea Leaf® will be giving you the chance to experience being a Solar Lamp Volunteer for a day at its 26th St. Bistro store in Bonifacio Global City from 3PM – 5PM.
A minimal fee of Php 950 is all you need (that is just an equivalent of cup of coffee a day x 1 week!) and you will be given access to know how to build a solar lamp.
It would be awesome to bring kids to this educational and meaningful event!
Let us help The Coffee Bean & Tea Leaf® in raising 100 eco-friendly solar lamps which will be donated to the underprivileged public school students from the Dumagat Tribe. The Dumagats are a community situated in Gabaldon, one of the most isolated villages in the Nueva Ecija Province. Nomadic in nature, the tribe has continued to live their simple day-to- day lives without electricity.
Let's give a gift of light!
For more info about this event, email caringcup@coffeebean.com.ph.
© ruthdelacruz | Travel and Lifestyle Blog : Learn How to Build a Solar Lamp with The Coffee Bean & Tea Leaf


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Funding for community groups up for grabs
Grants of up to £20,000 are available for a range of projects from the People's Postcode Lottery
25th July 2019 by Gareth Jones 0 Comments
Local charities and community groups are being encouraged to apply for funding of up to £20,000 from a pot worth over £3 million that has been raised by players of People's Postcode Lottery.
A wide range of community organisations, from registered charities, to community groups and social enterprises, can apply for grants of between £500 and £20,000. Applications are open from Wednesday 31 July for two weeks, until 14 August.
The funding is available through three different trusts, all of which are funded by players of People's Postcode Lottery.
Each trust supports projects focused on specific themes:
• People's Postcode Trust wants applications from projects aimed at promoting human rights, combatting discrimination and the prevention of poverty.
• Postcode Community Trust supports initiatives working to improve the health and wellbeing of communities, including arts and physical recreation projects, as well as those with a focus on reducing isolation.
• Postcode Local Trust provides funding to groups that are dedicated to improving outdoor space, in addition to increasing access to it. Groups working on flood prevention measures and looking to implement renewable energy strategies are also eligible to apply.
More than 300 groups were awarded grants earlier this year, with sports groups for military veterans, counselling support services for young carers and sensory gardens for people with dementia among the groups that benefitted.
Laura Chow, head of charities at People's Postcode Lottery, said: "It's not just players who win with People's Postcode Lottery - over £3 million in grants will have a tremendous impact on the fantastic work that grass-roots groups are doing in communities across Britain.
"Between the three trusts, there's scope for a huge array of projects to benefit and I would urge all groups to look at the funding guides and apply."
A minimum of 32% from every People's Postcode Lottery ticket goes directly to good causes. To date, players of People's Postcode Lottery have raised over £450 million for more than 6,500 good causes across Great Britain and internationally.
People's Postcode Lottery gives away £80 million > 28 August 2015
Postcode Lottery raises a record £20m > 29 January 2015
Race for Life 2020 launched
Castle reception launches awards
Brits "too ashamed" to donate gifts


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Courage Cultures
Witnessing a whole range of extraordinary acts of bravery over the last week has caused me to reflect on the smaller acts of courage that take place within our everyday lives. Every day, millions of people take deep breaths to do things that feel enormously difficult and which merit the label of 'courageous'.
Any readers who have attended one of my talks will have heard me mention the concept of 'courage cultures' at home. We know that it's mentally and physically beneficial to try things that perhaps frighten us at first. This might be getting on a skateboard or bike for the first time, or volunteering to do something that induces butterflies in the tummy. As parents, it can feel counterintuitive, mean even, to nudge our children towards things that make them feel nervous. However, if we don't, they risk never discovering what they are truly capable of, they risk never upskilling and they risk missing out on feelings that embolden them to do better, try harder and exploit life's rich opportunities.
I will give you an example. Last weekend, my son wasn't able to fulfil a promise of volunteering at a local charity shop. He had a good reason for this, but he still pleaded with me to make the tricky phone call to his 'employer'. We tried to brainstorm his 'fear of calling' together. What did he think was at the heart of his reluctance? What was the worst that could happen if he told his boss he couldn't come in? I suggested he needed to be '10% braver' and make the call himself.
By thinking through multiple scenarios and role-playing how the conversation might go, he felt slightly more able to give it a go. As he dialled, I noticed he put the call on speakerphone – the equivalent of asking me to watch him jump into a deep pool in case he couldn't swim and indicative of the fact he was still anxious about the outcome. Happily, the chap he spoke to was delighted to hear from him and grateful that he had been considerate enough to let him know he wouldn't be coming in.
Once our children make these little acts of courage, how can we respond in ways that optimise their learning? I once interviewed the eminent psychiatrist, Professor Tamsin Ford, and asked her how parents should react when children do something scary for the first time. Her reply underlined the importance of noticing their bravery and, rather than simply giving them a 'pat on the back', encouraging them to reflect on that most important of questions: "How did you manage to do that?" Reflection breeds resilience and gets children thinking through what it took to achieve their goal. What did you tell yourself so you could do it? What helped to calm your nerves? How do you feel now that you have done it? My son left that call feeling better about himself, mentally stronger, and more resilient about the prospect of difficult conversations in the future.
It can be a useful exercise to think about the bravery you have witnessed in your own life. In recent weeks, I have been moved by some of the everyday acts of courage that I've been told about by friends and professional contacts.
These include a friend who took the decision to be a 'whistle-blower' at work, risking his career (and his mental health) to hold a bully boss to account, a mum with a terminal illness telling her children the truth of her prognosis and an autistic teen who overcame a fear of a particular food after weeks of 1:1 support from a paediatric dietitian. None of these brave people knew how things would turn out, but they dived in and did it anyway.
Being brave requires us to expose ourselves emotionally to others, and this can feel deeply uncomfortable, for a time at least. As Professor Brené Brown, researcher and author, dictates, "You can't get to courage without 'rumbling with vulnerability'". We have to both occupy a state of vulnerability and live with uncertainty of outcome in order to reach a place where courage can be experienced.
Maybe we should all consider the brave conversations we wish we could have with family, colleagues or friends. The things we want to talk about, but utterly dread. How might we find the language to communicate that unmet need, that injustice, that regret? How might we find the words to say that we aren't happy with the status quo and wish for things to be different? Most importantly, how might we feel if it goes better than expected? Imagine the best outcome and consider how good you might feel on the other side of that conversation.
Now, the tricky bit. Deciding how, when and where to have that brave chat. Significant conversations, where the outcome might be nerve-wracking, require thought.
This is why, across various professions, people receive training on how to have difficult conversations; learning more about how to structure them, language that can open up dialogue, and appropriate, tried and tested strategies to manage an array of possible responses.
More often than not, at home, we avoid having difficult conversations because we simply don't know how to start. 'Starting poorly' might mean blurting something out that immediately places someone else into a state of pure defensiveness, or bringing something up at just the wrong time, when people are caught off guard.
Before starting, you should reconcile your own feelings about the conversation. What is the objective of this chat? What are the main points that you would like to get across? Then, consider the optimal context, timing and tone. It might be worth thinking through a time when a conversation definitely didn't go to plan; remember the last time you brought something up and it all went badly, quickly?
Consider giving the person(s) some warning and a little time to absorb the fact that you want this tricky conversation. "I was hoping that we could have a chat over the weekend, if that's ok? Could we set aside a little bit of time for it?" At this point, it's important to provide some sort of framework for the chat and state its purpose. These are the crunch moments and, as you step into that state of vulnerability, remember you are being brave. Be clear and be calm. Promise that you are looking forward to an exploratory chat together, rather than an argument.
Remember, not all tricky conversations need to happen across a table. Depending on who you are talking to, you might consider a side-by-side chat on a walk, a dinner combined with a chat, or a chat that takes place over days. Having a tripartite structure in your head may help. The first part of the conversation might involve 'discovery', where you share observations and learn how each other feels about a particular issue. Then, move into a deeper exploration (actively listening to each other's viewpoints) and finally, attempt to come to some sort of consensus and agree future actions.
In general, family life is something that I would encourage us all to regularly audit. How are things going for us? What are we doing well? What could work better? What one thing could we each do to enhance the quality of our family life?
If we can model courage to our children and show 'how' to have difficult conversations at home, we invest in their self-efficacy, agency and give them the best possible chance of having healthier and more authentic relationships themselves. So let's all aim to be 10% braver. Perhaps it will mean that we will be 10% happier too.
Over the last couple of weeks, we've added some brand new resources to the Tooled Up library, designed to help kickstart these tricky conversations about the good and the bad in family life. Make sure that you check out our top ten tips on making family conversation more productive, particularly when teens are involved. We've also created an accompanying template to use before and during these family audit meetings. If you have younger children, our My Family Life activity is a great way to prompt reflections on the positives and negatives of everyday life. It's not only in family life that we have tricky conversations. Sometimes, prospective chats with colleagues and friends can leave us feeling equally nervous. If this sounds familiar, take a look at our brand new conversation model, provided to Tooled Up by the fabulous relational coach and educator Sally Graham, which can be applied to any situation.
Don't forget that March is packed full of expert webinars on various subjects, exclusive to our Tooled Up community. You can book your free place on any of them now. Tonight, you can join me to learn evidence-based tips on how to help your child thrive academically, whilst also protecting their mental health. Take a look at all of the webinars we have on offer here.


Glamor Coral Necklace (Long) - Murano Glass Jewelry - Murano Glass Gifts Co.
The Murano glass beads are individually handmade to perfection. The artists take pains to craft these beads with diverse shape, color and embellishments. This Murano glass jewelry will be the dream of every woman. The necklace is a long version that comes to your chest. The Murano glass necklace is made of oblong cut beads of different sizes. The Murano glass necklace consists of cut beads of coral pink color and three smooth golden oblongs. Two of the beads are further embellished with small strands of seed beads. The oblong beads are strung in combination with seed beads of various colors and shapes. This Murano glass jewelry is a shimmering delight with pink and gold overtones.


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A Challenge Event is a walk mostly on footpaths and other Public Rights of Way (PROWs), across open fields and moors, avoiding tarmac as much as possible. The challenge is to the individual, e.g. 30 miles in 10 hours, it is NOT a race. The distances include at least one option over 20 miles - commonly 25, 26.2 ( Marathon) - with walks over 50 miles, e.g. 62 miles (100 kilometres) in 26 hours giving qualification for the LDWA's 'flagship' Event, held over the Spring Bank Holiday weekend in a different part of the country each year, namely, a Hundred Miles in 48 hours, with a limit of 500 participants.
Search For Challenge Event
By default this page shows a summary of all LDWA events occurring in the next 90 days. Please use the following options to choose the types of events you wish to see, then click on either the Show as Map or Show as List buttons. To see all events just click on one of the buttons without setting any options. To remove all options use the Clear button.
Events found. Scroll down to view.
Event Type: Challenge Event Group Walk Walking Festival
Local Group: LDWA Local Groups Non LDWA Anytime Anywhere Beds, Bucks and Northants Bristol & West Calderdale Central & Lowlands Cleveland Cornwall & Devon Cumbria Dorset East Lancashire East Yorkshire Essex & Herts Heart of England Heart of Scotland High Peak Isle of Wight Kent Lakeland Lincolnshire London Marches Merseystride Mid Wales Nidderdale Norfolk & Suffolk North West Grampian North Yorkshire Northumbria Sherwood South Manchester South Pennine South Wales Staffordshire Surrey Sussex Thames Valley The Irregulars Vermuyden (South Yorks) Wessex West Lancashire West Yorkshire Wiltshire Yorkshire Coast
From Date: (dd/mm/yyyy)
To Date: (dd/mm/yyyy)
Mileage Min:
Mileage Max:
Day Of Week: Saturday Sunday Monday Tuesday Wednesday Thursday Friday
Show Events within:
Only with GPX data
A Challenge event is a longer, organised, walk mostly on footpaths and other Public Rights of Way, across open fields and moors, avoiding tarmac as much as possible. The challenge is to the individual, e.g. 30 miles in 10 hours, it is NOT a race.
There are currently 43 local groups and being a member of one of these is great fun! Indeed, without them the LDWA would not exist. Local groups host regular group walks led by one of their members and some also organise social events and longer trips.
Want to find out about a long distance path? This website includes a searchable database of over 1,500 UK paths and trails covering more than 88,000 miles. Path information includes maps, publications, and accommodation near the path.
The annual 100 mile event is the LDWA's flagship event. Held every year in a different part of the country, to coincide with the late May Bank Holiday, up to 500 people gather to walk 100 miles in 48 hours.


I graduated from Shanghai Medical University (current Fudan University Medical Center) in 1989; then I was trained at Shanghai Zhongshan Hospital in Internal Medicine Residency and Gastroenterology Fellowship (1989-1995); in the meantime, I got my PhD of Medical Science of Gastroenterology. I worked as a gastroenterologist in the same hospital for over a year (1995-1996); then I came to the United States worked as Postdoctoral Associate at Cornell University (1996-2002). From 2002-2005, I was re-trained in Internal Medicine Residency at the University of South Dakota School of Medicine; after that, I entered a Gastroenterology Fellowship Program at the Brigham and Women's Hospital, Harvard Medical School. In June 2008, after my Gastroenterology Fellowship training, I joined Kaiser Permanente Northwest as a gastroenterologist. At Kaiser Permanente, patient care is our first priority, I love Kaiser Permanente.
I was fortunate to get the opportunity to work at Northwest Permanente Gastroenterology Department. We have a wonderful collegial group providing excellent gastroenterology and hepatology service. Specifically, I do general gastroenterology and hepatology consultation in GI Clinic; I perform upper endoscopy (with biopsy, stricture or ring dilation, polypectomy---polyp removal, esophageal variceal ligation---banding, Argon Plasma Coagulation---APC and cauterization treatment for bleeding control, etc), colonoscopy (with polyp removal; cauterization, APC or clipping for bleeding control; stricture dilation, etc), liver biopsy, paracentesis (belly fluid removal), percutaneous endoscopic gastrostomy---PEG placement, and capsule endoscopy (capsule video camera to check small intestine).
I have a beautiful wife and two handsome sons (a freshman in high school and a preschooler). After work, family is my priority; I spend a lot of my spare time with my family. I enjoy a lot teaching my sons' Chinese language (although they may not enjoy that much); we go to library and book stores frequently, we travel to different areas a few times a year. I also enjoy doing some clinical work during my off days, such as making some phone calls to my patient s for follow-up, checking lab results, or replying to patient emails.


text:
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But my work shows that in 17th-century England, at any given time, more women were unmarried than married. By political reporter Stephanie Borys. Read about our editorial guiding principles and the standards ABC journalists and content makers follow.
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By Henar Herrero (Universidad de Castilla-La Mancha), in collaboration with Damián Castaño y María Cruz Navarro.
There are different atmospheric phenomena with the common factor of vortex dynamics, from small events such as dust devils (figure 1) and tornadoes, to large events as hurricanes and cyclones [4,5]. Thermal convection is a relevant process involved in their formation and evolution. In thermal convection, the fluid motion is caused by buoyancy forces that results from the density variations due to thermal gradients in the fluid. The simplest case of thermal convection is the well-known Rayleigh Bénard convection where cells or rolls appears in a horizontal fluid layer heated from below . Instability occurs at the minimum temperature gradient at which a balance can be steadily maintained between the kinetic energy dissipated by viscosity and the internal energy released by the buoyancy flow . One of the hypothesis for the genesis of these atmospheric vortices is thermoconvective instability in a stratified layer. Many questions from different fields need to be solved, from the physical model to the numerical methods to solve the differential equations (figure 2) .
 Bénard H. Les tourbillons cellulaires dans une nappe liquide. Rev. Gén. Sci. Pure Appl. 11, 1261-1271, 1900.
 Castaño, D., Navarro, M. C. and Herrero, H. Routes to chaos from axisymmetric vertical vortices in a rotating cylinder. Mathematical Modelling. doi: 10.1016/j.apm.2017.09.010, 2017.
 Chandrasekhar S. Hydrodynamic and Hydromagnetic Stability. Dover Publications, New York, 1981.
 Emanuel K. A. Divine wind. Nature. Oxford University Press, Oxford, 2005.
 Sinclair P. C. General characteristics of dust devils. J. Appl. Meteorol. 8, 32-45, 1969.


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OpenMx entered public beta testing on October 8, 2009. The OpenMx website is now accepting self-registration. Go to the website, register, login, and download the most advanced free and open source Structural Equation Modeling package available. Registration also allows posting access to the OpenSem forums. Let us know what you think!
This article presents a computational framework suitable for a data-driven approach to structural equation modeling (SEM) and describe several workflows for modeling functional magnetic resonance imaging (fMRI) data within this framework. The Computational Neuroscience Applications Research Infrastructure (CNARI) employs a high-level scripting language called Swift, which is capable of spawning hundreds of thousands of simultaneous R processes (R Core Development Team, 2008), consisting of self-contained structural equation models, on a high performance computing system (HPC). These self-contained R processing jobs are data objects generated by OpenMx, a plug-in for R, which can generate a single model object containing the matrices and algebraic information necessary to estimate parameters of the model. With such an infrastructure in place a structural modeler may begin to investigate exhaustive searches of the model space. Specific applications of the infrastructure, statistics related to model fit, and limitations are discussed in relation to exhaustive SEM. In particular, we discuss how workflow management techniques can help to solve large computational problems in neuroimaging.
Frontiers in Neuroscience is an open-access journal, so a PDF of the article can be downloaded for free.
Ong, A. D., Bergeman, C. S., & Boker, S. M. (2009) Resilience in Adulthood Comes of Age: Defining Features and Dynamic Conceptions. Journal of Personality. 77:6.
This article begins with a selective review of the broad literature on resilience, giving emphasis to the major approaches, empirical findings, and guiding principles that characterize prior studies. It then summarizes an approach to the phenomenon of resilience and illustrate select parts of previous and ongoing studies of older adults. Findings from this research add to the growing body of empirical evidence suggesting that resilience is a common phenomenon that emerges from the coordinated orchestration of basic human adaptive processes.
This article is previewed on the Journal of Personality website and will appear in the December issue. Unfortunately, Wiley/Blackwell rules would require us to pay at $3,000 fee if we were to either provide a downloadable copy or send a pdf as a response to a reprint request. However, since NIH funded parts of this work, Wiley/Blackwell is required to submit the final published version to pubmed. Hooray for NIH! When the free pubmed version is available, a link to that version will appear here.


There is a new four-story Marriott hotel going up fast in Kenosha County. So fast, that it'll actually be checking in guests in early October.
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Nankin says guests won't be able to tell the difference between a modular-ly constructed hotel versus a traditionally built one.


text:
Q: Dragging mouse on an image, showing another image underneath I'm a beginner with writing code so I'm struggling a bit with this one.
I want to have two images layered on top of each other, and when you use your mouse on it like dragging or painting, the image underneath will show in the places you've traced.
I've been using these as source, but none of them use an image on top and I haven't been able to replace the top layer with an image:
https://rifke.world
https://codepen.io/uargh/pen/eYmoXgJ
I think I'll probably need ctx.globalCompositeOperation="destination-out"; but I'm not too sure how to apply it to an image
Any help would be very appreciated since I've been fighting with this for a while.
Thanks! :)

A: You'll want a static image and a canvas element, pretty much what the link you included is doing. Here's the code from that site to dig into further how they are updating the canvas element for that effect. https://rifke.world//js/script.js?ver=1.4.
You can draw the image you want on top on the canvas element using the following method https://www.w3schools.com/tags/canvas_drawimage.asp.

A: I do not see anywhere that you are loading a second image, I think you should do something like:
var img2=new Image();
img2.onload=function(){
    ctx.drawImage(img2,0,0);
};
img2.src="http://placekitten.com/700/1023";

I tried it here, looks like this achieves what you are trying to do.
Besides, you can use PageX and PageY instead of ClientX and ClientY, so that your code works as expected when page is scrolled.


Celebrity Deathmatch! is a claymation show on MTV. It features fights-to-the-death between bickering celebrities and a lot of gimmicks. There have been fights like Ben Affleck vs. Matt Damon, Jim Carrey vs. Mariah Carey, and the like. It has grown quite popular, and you can see special episodes of it during halftime of the Super Bowl, when it originally premiered. Recurring guests on the show include WWF superstar "Stone Cold" Steve Austin and controversial rock star Marilyn Manson.
For more information about Celebrity Deathmatch!, see the Deathmatch! homepage through the links area.
One day, RPM Author Jay Winger was watching MTV and caught a marathon of Celebrity Deathmatch! on "Stone Cold Whoopass Animation Weekend." He got the idea to pit RPM characters against ReBoot characters on the RPM mailing list. He pitched his idea, Metaverse Deathmatch! (MDM), to the list and it soon grew into a highly entertaining thread that earned a spot on the RPM website.
Since then, MDM has had two distinct forms: Phase One, which had shorter posts and was more often than not vignettes of matches, and Phase Two, the current stage, which has longer and more in-depth posts and intense fighting. Archived posts from both phases may be found in the archive area.
What is the deal with the 'Night' system?
The term 'night,' when used in MDM, is to denote a series of matches that are all supposed to take place within one night's worth of events. Not all of the matches are written at once, but over the course of a few weeks, as details are worked out between the involved Authors. As Phase Two got more involved, it became obvious that the 'night' system was no longer literal.
How can I get involved in MDM?
Well, unless you are an RPM Author (meaning you have Metaverse fiction either part-way or completely done), you can't get directly involved -- by which we mean writing direct posts. You can, however, contribute, by suggesting match concepts or plot-line concepts to the Authors. To do so, write an email to the Author(s) in question. You can also get involved by doing artwork or mixing sound files (see the Media Gallery).
What's been going on in MDM?
That question is a lot more complicated. Since Phase Two began, an intense Rivalry (yes, it is usually capitalized) has emerged between the Authors Jay Winger and Voodoo. The Rivalry has affected MDM as a whole, forcing most of the other Authors to choose sides. Jay Winger's main advantage is his "controlling share" over MDM, and his tight relationship with the other owners of the MDM Stadium. This allows him to exert enormous influence over what matches occur and sometimes the outcome of said matches. Voodoo's main advantage is his more advanced technology and his characters' enhanced abilities. The Rivalry has surfaced in many matches, including a major battle between the Authors themselves, ending in Voodoo's coma (which lasted less than a day, due to outside influence).
But if you really want to find out the full story, you have to read the archived posts.
What's the deal with the Arena and Archive pages?
The Arena page is where the matches of each night are posted, and it is updated as its status changes. That means at the beginning of the night, all the booked matches are listed. As the posts are made, the page is updated, informing the viewer as to who won each match. It also keeps track of what coalitions or alliances are forming. When the new night begins, the old data may remain up for a week or two before it is taken off.
The Archives are where old nights' posts are kept for the viewers' perusal. Almost every post from the beginning of Phase One to the end of the most recent night of Phase Two is kept here. The page is only updated after a night is over and done with.


text:
package summary

import (
	"fmt"
	"math"
	"sort"

	info "github.com/google/cadvisor/info/v2"
)

const secondsToMilliSeconds = 1000
const milliSecondsToNanoSeconds = 1000000
const secondsToNanoSeconds = secondsToMilliSeconds * milliSecondsToNanoSeconds

type Uint64Slice []uint64

func (a Uint64Slice) Len() int           { return len(a) }
func (a Uint64Slice) Swap(i, j int)      { a[i], a[j] = a[j], a[i] }
func (a Uint64Slice) Less(i, j int) bool { return a[i] < a[j] }

// Get percentile of the provided samples. Round to integer.
func (self Uint64Slice) GetPercentile(d float64) uint64 {
	if d < 0.0 || d > 1.0 {
		return 0
	}
	count := self.Len()
	if count == 0 {
		return 0
	}
	sort.Sort(self)
	n := float64(d * (float64(count) + 1))
	idx, frac := math.Modf(n)
	index := int(idx)
	percentile := float64(self[index-1])
	if index > 1 && index < count {
		percentile += frac * float64(self[index]-self[index-1])
	}
	return uint64(percentile)
}

type mean struct {
	// current count.
	count uint64
	// current mean.
	Mean float64
}

func (self *mean) Add(value uint64) {
	self.count++
	if self.count == 1 {
		self.Mean = float64(value)
		return
	}
	c := float64(self.count)
	v := float64(value)
	self.Mean = (self.Mean*(c-1) + v) / c
}

type resource struct {
	// list of samples being tracked.
	samples Uint64Slice
	// average from existing samples.
	mean mean
	// maximum value seen so far in the added samples.
	max uint64
}

// Adds a new percentile sample.
func (self *resource) Add(p info.Percentiles) {
	if !p.Present {
		return
	}
	if p.Max > self.max {
		self.max = p.Max
	}
	self.mean.Add(p.Mean)
	// Selecting 90p of 90p :(
	self.samples = append(self.samples, p.Ninety)
}

// Add a single sample. Internally, we convert it to a fake percentile sample.
func (self *resource) AddSample(val uint64) {
	sample := info.Percentiles{
		Present:    true,
		Mean:       val,
		Max:        val,
		Fifty:      val,
		Ninety:     val,
		NinetyFive: val,
	}
	self.Add(sample)
}

// Get max, average, and 90p from existing samples.
func (self *resource) GetAllPercentiles() info.Percentiles {
	p := info.Percentiles{}
	p.Mean = uint64(self.mean.Mean)
	p.Max = self.max
	p.Fifty = self.samples.GetPercentile(0.5)
	p.Ninety = self.samples.GetPercentile(0.9)
	p.NinetyFive = self.samples.GetPercentile(0.95)
	p.Present = true
	return p
}

func NewResource(size int) *resource {
	return &resource{
		samples: make(Uint64Slice, 0, size),
		mean:    mean{count: 0, Mean: 0},
	}
}

// Return aggregated percentiles from the provided percentile samples.
func GetDerivedPercentiles(stats []*info.Usage) info.Usage {
	cpu := NewResource(len(stats))
	memory := NewResource(len(stats))
	for _, stat := range stats {
		cpu.Add(stat.Cpu)
		memory.Add(stat.Memory)
	}
	usage := info.Usage{}
	usage.Cpu = cpu.GetAllPercentiles()
	usage.Memory = memory.GetAllPercentiles()
	return usage
}

// Calculate part of a minute this sample set represent.
func getPercentComplete(stats []*secondSample) (percent int32) {
	numSamples := len(stats)
	if numSamples > 1 {
		percent = 100
		timeRange := stats[numSamples-1].Timestamp.Sub(stats[0].Timestamp).Nanoseconds()
		// allow some slack
		if timeRange < 58*secondsToNanoSeconds {
			percent = int32((timeRange * 100) / 60 * secondsToNanoSeconds)
		}
	}
	return
}

// Calculate cpurate from two consecutive total cpu usage samples.
func getCpuRate(latest, previous secondSample) (uint64, error) {
	var elapsed int64
	elapsed = latest.Timestamp.Sub(previous.Timestamp).Nanoseconds()
	if elapsed < 10*milliSecondsToNanoSeconds {
		return 0, fmt.Errorf("elapsed time too small: %d ns: time now %s last %s", elapsed, latest.Timestamp.String(), previous.Timestamp.String())
	}
	if latest.Cpu < previous.Cpu {
		return 0, fmt.Errorf("bad sample: cumulative cpu usage dropped from %d to %d", latest.Cpu, previous.Cpu)
	}
	// Cpurate is calculated in cpu-milliseconds per second.
	cpuRate := (latest.Cpu - previous.Cpu) * secondsToMilliSeconds / uint64(elapsed)
	return cpuRate, nil
}

// Returns a percentile sample for a minute by aggregating seconds samples.
func GetMinutePercentiles(stats []*secondSample) info.Usage {
	lastSample := secondSample{}
	cpu := NewResource(len(stats))
	memory := NewResource(len(stats))
	for _, stat := range stats {
		if !lastSample.Timestamp.IsZero() {
			cpuRate, err := getCpuRate(*stat, lastSample)
			if err != nil {
				continue
			}
			cpu.AddSample(cpuRate)
			memory.AddSample(stat.Memory)
		} else {
			memory.AddSample(stat.Memory)
		}
		lastSample = *stat
	}
	percent := getPercentComplete(stats)
	return info.Usage{
		PercentComplete: percent,
		Cpu:             cpu.GetAllPercentiles(),
		Memory:          memory.GetAllPercentiles(),
	}
}

redpajama_set_name: RedPajamaGithub