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How could Stem Cells be Used in Drug Discovery?
By Gemma North, MScReviewed by Emily Henderson, B.Sc.
Stem cells can develop into multiple different cell types during early life and during growth. They can also act as a repair system in multiple types of tissue due to their ability to divide and, therefore, replenish other cells.
Image Credit: Snailstudio/Shutterstock.com
During stem cell division, one cell remains as a stem cell whilst the other gains a capacity to have a specialized function. Stem cells have two key characteristics that allow them to be distinguished from other cells.
Firstly, they are unspecialized and can replicate indefinitely, even after a long period. In addition to this, they can gain a specialized function in an organ or tissue under certain conditions.
The gut and the bone marrow possess stem cells that divide regularly to replace worn out and damaged tissues. On the other hand, the heart and pancreas have stem cells that will only divide under certain conditions.
Stem cells have a huge amount of potential in regard to aiding the search for better drugs, and therefore their ability to treat human disease.
Drug research and development
The concept of stem cells is an area that has generated a lot of interest in previous years. Stem cells themselves offer a new avenue for both drug research and development in addition to providing a new avenue of examining the pathological basis of disease.
Therefore, this provides a new means for drug screening, testing the efficacy of potential new drugs, and screening patient populations for clinical trials.
The process by which stem cells would be used in the process would firstly be to identify a disease of interest and obtain samples. From this induced pluripotent stem cells (iPSCs) can be generated and expanded and differentiated into different components or cells also associated with the diseases.
Image Credit: Jan Bruder/Shutterstock.com
The key examples often associated with stem cell research are motor neurons due to their involvement in ALS or spinal muscular dystrophy. After the initial studies have taken place exploring disease mechanisms further screens can take place for drug discovery.
From this, compounds can be identified and pursued, whilst the efficacy and safety of the compounds can be interrogated through their effects on other cell lines. These differing cell lines may include ones that are influenced by side effects e.g. cardiomyocytes and hepatocytes.
Lead compounds identified at this stage can be tested further on patient-derived cells. Using patient-derived cells, it can help determine whether compounds could be more effective in a larger percentage of patients or even determine who is most likely to respond best to this newly identified compound.
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From a translational perspective, this could be highly beneficial in reducing the costs associated with bringing a new drug to patients and the market as they can be highly interrogated in the preclinical stages.
This strict preclinical testing also allows for the development of safety profiles in addition to more carefully considering the target population.
It is important to consider the maturity of the cell when modeling diseases as this could differ from the cell phenotypes seen in patients. ALS and SMA are both motor neuron diseases, however, they influence different cell subpopulations.
Within ALS, it is the innervating distal nerve cells that are affected. Whilst in SMA, the proximal muscles are affected; common to both diseases some motor neurons are not affected at all. Therefore, in attempts to model these diseases, one should attempt to model these specific subpopulations of neurons.
Whilst there are protocols in place to generate motor neurons, the neurons generated are not representative of a specific subpopulation. It is plausible to suggest that these generic neurons could be induced to differentiate further into more distinct motor neuron niches through exposure to morphogens and different stimuli such as transcription factors.
Furthermore, typically cells that have differentiated from pluripotent stem cells resemble their embryonic counterpart. When modeling late-onset diseases this can present problems as the cells generated would not be true of their mature phenotype exhibited in cells.
Due to the nature of neurodegenerative diseases taking many years to affect humans and in in vivo taking several months to become clinically apparent. Furthermore, neurodegenerative diseases are often sporadic and initiated by environmental cues.
Therefore, when these stem cells are exposed to these stimuli or cues in a concentrated and often long duration it can accelerate the pathological phenotype within a cell culture phenotype. A typical example of this would be using cellular pro-oxidants which can mitigate mitochondrial function and therefore influence the disease phenotype.
Lastly, neurodegenerative diseases are predominantly late-onset and sporadic in their presentation. Conversely, there is a small number of cases whereby there are distinct mutations present.
Moving forward with this presumption, one could establish an in vitro phenotype using genetic variants of the disease and attempting to alter the cell culture conditions to produce a similar disease pathology.
Future outlook
Stem cells possess numerous qualities that are an attractive option in improving the drug discovery pipeline and from the basic biology standpoint. Their properties allow us to develop many disease-relevant cells and subsequently establish possible new drug targets.
In addition, we can also gain a better insight into the disease mechanism. However, the research into stem cell biology is still limited due to the generic cell type generated rather than a specific niche which would better demonstrate the disease and its pathology.
Therefore, further work needs to be undertaken to generate specific cell niches to generate novel compounds.
Image Credit: Gorodenkoff/Shutterstock.com
Takahashi, Kazutoshi et al. Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors Cell,. Volume 131, Issue 5, 861 - 872
Peljto M, Dasen JS, Mazzoni EO, Jessell TM, Wichterle H. Functional diversity of ESC-derived motor neuron subtypes revealed through intraspinal transplantation. Cell Stem Cell. 2010;7:355–366.
Nguyen HN, Byers B, Cord B, Shcheglovitov A, Byrne J, Gujar P, Kee K, Schüle B, Dolmetsch RE, Langston W, Palmer TD, Pera RR. LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress. Cell Stem Cell. 2011;8:267–280.
Saha, K., & Jaenisch, R. (2009). Technical challenges in using human induced pluripotent stem cells to model disease. Cell stem cell, 5(6), 584–595. https://doi.org/10.1016/j.stem.2009.11.009
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Gemma North
Gemma has a BSc in Biological Sciences from the University of East Anglia and an MSc(Res) Translational Oncology from the University of Sheffield. Her master's thesis explored drug redeployment in multiple myeloma specifically looking at the effects of niclosamide and valproate. The study has broader implications for myeloma patients where therapies are often aggressive and not always suitable due to the demographic of patients.
North, Gemma. (2021, January 28). How could Stem Cells be Used in Drug Discovery?. AZoLifeSciences. Retrieved on January 20, 2022 from https://www.azolifesciences.com/article/How-could-Stem-Cells-be-Used-in-Drug-Discovery.aspx.
North, Gemma. "How could Stem Cells be Used in Drug Discovery?". AZoLifeSciences. 20 January 2022. <https://www.azolifesciences.com/article/How-could-Stem-Cells-be-Used-in-Drug-Discovery.aspx>.
North, Gemma. "How could Stem Cells be Used in Drug Discovery?". AZoLifeSciences. https://www.azolifesciences.com/article/How-could-Stem-Cells-be-Used-in-Drug-Discovery.aspx. (accessed January 20, 2022).
North, Gemma. 2021. How could Stem Cells be Used in Drug Discovery?. AZoLifeSciences, viewed 20 January 2022, https://www.azolifesciences.com/article/How-could-Stem-Cells-be-Used-in-Drug-Discovery.aspx.
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After waiting for so long, Airtel has finally launched its own MyAirtel self-service app in 3 countries, which are India, Bangladesh and Sri Lanka.
MyAirtel app is similar to My9mobile and MyMTN app. MyAirtel app is a self-service platform which has been designed to serve yourself on anything concerning your Airtel sim without having to call the customer care service.
Some of the services you can get on the app includes but not limited to manage your Airtel line, recharge your line, buy data plans, VAS services and more. The app also offers entertainment content too.
MyAirtel self-service app is available for Android, iOS and Windows phone, but currently available in 3 countries, India, Bangladesh and Sri Lanka. The app is for both postpaid and prepaid subscribers and browsing on the app is totally free.
The MyAirtel self-service app is available for Android, iOS and Windows users.
Download for Android HERE (India).
Download for Windows 10 HERE.


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Home/Uncategorized/Take a Virtual Tour Through Humboldt's Fern Canyon
Take a Virtual Tour Through Humboldt's Fern Canyon
Humboldt's Fern Canyon has become one of the most popular outdoor destinations in Northern California, with its 50-foot walls covered in ferns. The hike through the canyon is uniquely picturesque, much like walking through an ancient forest filled with dinosaurs.
Since many of us are currently stuck at home, there's another way you can enjoy the scenes of Fern Canyon – by going on a virtual hike. The below video does a fantastic job illustrating the beauty of the area:
Here is the description from the YouTube page The Flying Dutchman:
Located in Prairie Creek Redwoods State Park, it takes a bit of work to get to the North Coast gem known as Fern Canyon, but it's worth it. From Highway 101 at Orick, drive unpaved Davison Road 10 miles to this spectacular canyon, a hidden paradise of ferns lining a narrow gorge carved out by Home Creek. Some of the seven different types of ferns clinging to the steep cliffs are ancient species, with ancestry tracing back 325 million years. Living underneath their leafy shade are some eye-catching amphibians, including Pacific giant salamanders, which can measure nearly a foot in length, and northern red-legged frogs.
The trail follows a series of small footbridges (installed in summer) deep into the canyon. Lush, drooping ferns create hanging gardens, miniature waterfalls pour down rock faces, and moss wallpapers every surface. The walls grow taller and squeeze tighter as you travel.
Are you experiencing déjà vu? Steven Spielberg filmed a Jurassic Park II scene within this canyon. Every curve and turn leads to another Instagram-it-now (if there were reception) view. Far too soon, the trail curves left and ascends out of the canyon, then loops back to the parking lot. More than a few Fern Canyon hikers opt to retrace their steps instead of continuing on the loop—it's just too hard to leave this special place.
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redpajama_set_name: RedPajamaCommonCrawl


Craig Lambert is an experienced public speaker who is available for engagements at corporations, associations. nonprofits, and educational venues. He brings a witty, lively style to the podium, combining humor with stimulating ideas.
Craig offers two programs, both of which include photographs and illustrations. The first, "Shadow Work," explains and illustrates the emerging socio-economic phenomenon that his book of that title describes. See the SHADOW WORK page of this website for details on the book as well as reviews and media coverage.
The second program, "How Harvard Changed Comedy," describes, with abundant examples, the impact that comedy writers and performers trained at the Harvard Lampoon have had on American humor over the past century. It focuses on the decades since the founding of National Lampoon magazine by three Harvard alumni in 1970. Craig takes the audience behind the scenes at Saturday Night Live, Animal House, Caddyshack, David Letterman, The Simpsons, and many other radio and TV comedies; he touches on performers including Conan O'Brien, Al Franken, Fred Gwynne, George Plimpton, Patricia Marx, and Andy Borowitz.
Audio recording of Craig Lambert speaking on Shadow Work at Harvard Book Store in Cambridge, Massachusetts, May 12, 2015.


At the end of 2015, Dr. Robert Munford stepped down as Treasurer of the International Endotoxin and Innate Immunity Society. Since 2012, he has done a highly remarkable job and has given the Society many years of dedicated and highly reliable service. Thank you very much, Bob. All members of the Society owe you a great debt of gratitude!
As of January 2016, Dr. Amy Hise is the new Treasurer of our Society. When I asked her, Amy (who is also our Scientific Councilor – Pathology) did not hesitate to take over, and she and Bob arranged the transfer in a very efficient and smooth way. Thank you very much, Amy, for your willingness to serve the Society in the future, and we all look forward very much to collaborating with you! Amy can be contacted at Amy.Hise@case.edu.


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és una escriptora toquiota nascuda el 1949, també coneguda pel nom de ploma  com a cocreadora del manga shōjo Candy Candy junt amb la dibuixant Yumiko Igarashi.

De jove, Nagita volia ser escriptora: influïda per Anne of Green Gables, Pollyanna o A Little Princess, començà a escriure històries per a xiques. als dèsset anys guanyà un premi d'una revista especialitzada en literatura juvenil i, als dèneu, publicà la primera novel·la, de resultes de la qual rebé una oferta d'un editor de manga per a escriure guions: «Estaria bé que escrigueres un guió de manga de l'estil d'eixes novel·les que t'agraden, com Anna de les teules verdes, Daddy Long Legs o Princesa Sarah.»

L'editor també li presentà Yumiko Igarashi amb la idea que col·laboraren: Igarashi fins llavors no havia dibuixat cap de manga ambientat en l'estranger, però féu lliga amb Nagita i obtingueren molta nomenada amb la publicació de  entre 1975 i 1979 en la revista Nakayoshi, recopilada en nou volums tankōbon i adaptada a l'anime (en una sèrie de televisió i una pel·lícula) per Toei Animation i en tres novel·les publicades per Kōdansha amb l'argument reescrit per la mateixa Nagita, tot amb el pseudònim de Kyōko Mizuki.

Després de Candy Candy'', Nagita reprengué la seua vocació de novel·lista i publicà diverses obres del mateix estil. L'èxit continuat de les reemissions de l'anime afavoriren una altra pel·lícula el 1992 i la producció continuada de merxandatge i d'art original, fins que l'any 1998 Igarashi i Nagita s'enfrontaren judicialment pels drets de la franquícia, ja que la primera se'ls havia atribuït en exclusiva, però tres senténcies consecutives donaren la raó a Nagita quant a la compartició dels drets i permisos d'explotació, entre els quals el dret a novel·lar la sèrie sense permís d'Igarashi o fins i tot a col·laborar amb altres dibuixants. El 2002, Nagita anuncià que treballava en una revisió de la sèrie malgrat el pleit continuat.

Referències

Guionistes de còmics
Manga
Autors de còmic japonesos
Guionistes japonesos
Artistes de Tòquio

redpajama_set_name: RedPajamaWikipedia


The Grove Plaza is not just a great place to spend your time, it also is a great example of how an urban renewal project can spark economic development. The history of the plaza is rich and the future is full of improvements.
You can learn more about The Grove Plaza's past, present, and future by clicking on the links below.


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Civilian/News
Attorney General Speaks about Need for Public Defenders
Attorney General Eric Holder spoke at a meeting for North Carolina Advocates for Justice meeting this past weekend and highlighted the need for legal representation for those who cannot afford it.
In his address, Holder called the legal system "overburdened" as public defenders have too large a caseload without adequate finances to properly fulfill their ethical responsibility to their clients. In turn, these circumstances result in a system that is not performing to its fullest and necessary capabilities.
"Unfortunately, the challenges facing North Carolina's public-defender program – a lack of staff and increasingly limited resources – are the rule, not the exception," the attorney general said.
To fix this, Holder pushed the Access to Justice Initiative, a program that would give all Americans better access to legal representation. He also explained more communication, awareness and encouragement for defenders were needed to help this initiative achieve full success.
"The initiative was established to fulfill our responsibility to enhance the fairness and integrity of our legal system, and it reflects an historic assurance that expanding access to legal services is, and will continue to be, a national priority," Holder said. "And I'm pleased to report that this new office has hit the ground running with an ambitious agenda."
The meeting was held in hopes to gain back what the justice system had lost in terms of adequate legal defense. Holder hopes his address will contribute to the movement toward better representation, regardless of income.
"I have no doubt that many of the attorneys and advocates gathered in this room will contribute to its success," he said.
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Army Researchers See Potential of Low-Cost Tech in Dynamic Threat Training; Eric Holder Quoted
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Eastleigh Works Blog: Two Major Lifts in Two Days!!
On Tuesday 25th January, 50026 was lifted for a replacement traction motor to be fitted. The following day, Wednesday 26th January, the boiler was successfully lifted off 'CHELTENHAM', marking a milestone in the overhaul of the loco.


I'm a Southern California native and San Diego has been my home for quite a few years now. I love going to the beach, hiking with my dog, attending live music shows and spending time with friends and family. I'm passionate about animals, yoga, art and surrounding myself with positive people and energy. Life has taken me on a wild journey but it's landed me here at BhuFoods and I couldn't be more grateful. Only good things to come.


An audio recording of the Board of Regents, Presidential Search Committee, meeting from January 24, 1992.
Morehead State University. Board of Regents. and Presidential Search Committee, "1992-01-24 (audio)" (1992). Morehead State Board of Regents Agenda Books and Meeting Minutes. 673.


Mold and most fungi are present everywhere, indoors and outdoors environments. Most are usually dormant until water is added to the area. Water not only will add to the condition needed for fungal microbes to grow (temperature, light, moisture), but it also brings more contamination through the carrying of new spores from other areas.
Givens Disaster Restoration has developed essential and effective processes to properly remediate your home or office. For instance, containment is an extremely important step in the process as it prevents the air bone spores from contaminating other areas of your home or office.
If mold remediation is done improperly, it can easily do more harm than good. Our technicians will develop a mold remediation plan specific for your needs, ensuring your problem is remedied quickly and effectively.
At Givens Disaster Restoration, we are experts at remediation and restoration. This is what we do best. In addition, we have strong relationship with local construction companies who are experts at construction. They will do an expert job in the rebuild process, as we will in the remediation process.
Givens Disaster Restoration has trained and uniformed employees who work around the clock to respond to your loss because we understand quick response can prevent additional damage to your home or office. Givens Disaster Restoration proved written, detailed, by room scopes and estimates. We will describe everything that will be done in the remediation process, which will support our detailed estimate.


Reservations required. PRIVATE EVENT - Invitation ONLY.
Add your town and zip code or any special requests when placing your order in Special Requests field above. Text can be anything you like, town and zip, last name, a quote.... Design must be confirmed ahead of time.
Please specify which color text for your piece and the TEXT and piece of art you want. You will choose your background color the night of the party.


The Analytical Writing Assessment (AWA) is designed to measure your ability to think critically and to communicate your ideas. The AWA consists of one 30-minute essay.
Analysis of an Argument:The argument presented on the test concerns topics of general interest related to business or a variety of other subjects. Specific knowledge of the essay topic is not necessary; only your capacity to write analytically is assessed.
You will be asked to analyze the reasoning behind a given argument and write a critique of that argument. You are not being asked to present your own views on the subject.
· What questionable assumptions underlie the thinking behind the argument?
· What alternative explanations or counterexamples might weaken the conclusion?
· What sort of evidence could help strengthen or refute the argument?
Analysis of an Argument tests your ability to formulate an appropriate and constructive critique of a specific conclusion based on a specific line of thinking.
For an example and directions for answering, go to the Sample Analysis of an Argument Question.
You may download the complete list of current Analytical Writing Assessment (AWA) Analysis of an Argument Topics used during the administration of the GMAT exam.
Independent readers will rescore your essays for a fee of US$45. The Integrated Reasoning, Quantitative, and Verbal sections of the test cannot be rescored.
Rescoring may result in an increase or decrease in your AWA score. Either way, the rescoring results are final. Revised results will be sent to you and to the graduate management programs you designated as score recipients approximately 20 days after your request is received. Once your rescoring request has been processed, the fee will not be refunded.
Showcase your highly valued integrated reasoning skills, which are keys for success in the classroom and workplace.
· Almost all question formats require multiple responses. Questions are designed to measure how well you integrate data to solve complex problems, so you must answer all parts of a single question correctly to receive credit.
· All answer choices for a single question are presented on the same screen. You must submit responses to all parts of the question before moving on to a new question on another screen. Once you answer a question, you may not go back and change the answer.
· Data presented in text are approximately 300 words or fewer.
· Answer options don't provide information or clues that will help you solve other questions.
· One set of data is used for several Multi-Source Reasoning questions, but the questions are independent of one another—you won't have to answer one question correctly to be able to answer another.


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Neriene clathrata es una especie de araña araneomorfa del género Neriene, familia Linyphiidae. Fue descrita científicamente por Sundevall en 1830.

Habita en América del Norte, Europa, África del Norte, Cáucaso, Rusia (Europa al Lejano Oriente), Irán, Asia Central, China, Corea y Japón.

Referencias

Enlaces externos
 Neriene Global Biodiversity Information Facility.

clathrata


Kate has severe morning sickness but joined husband William and Prince Harry for an event to mark World Mental Health Day.
The Duchess of Cambridge has debuted her royal baby bump, appearing in public for the first time since it was announced she is expecting her third child.
Kate, who has severe morning sickness, joined husband Prince William and brother-in-law Prince Harry at a reception at Buckingham Palace to mark World Mental Health Day.
Despite still suffering from severe vomiting (hyperemesis gravidarum), she looked relaxed and was showing signs of a tiny baby bump.
The palace has not announced when the baby is due but it is believed Kate is less than 12 weeks pregnant.
A royal aide said: "The Duchess' condition is improving but she's still suffering from hyperemesis gravidarum. She's delighted to be here tonight."
Pregnant Kate appears in public... any sign?
The Duke and Duchess and Prince Harry met leading figures in the mental health sector at the reception, including Mind president and comic Stephen Fry.
At an event earlier in the day, Prince William explained in a speech that it was his wife who first decided the trio should join together to focus on mental health.
William said: "It was Catherine who first realised that all three of us were working on mental health in our individual areas of focus.
"She had seen that at the core of adult issues like addiction and family breakdown, unresolved childhood mental health issues were often part of the problem.
"Harry had seen that it wasn't enough to help veterans recover from their physical injuries without acknowledging the emotional and mental support they required.
"And after years of working with the homeless, and having been called out to multiple scenes of suicide as a search and rescue and then HEMS (helicopter emergency medical services) pilot, I understood the damage poor mental health was causing to our communities and for our families."
The Duchess has not been seen in public since 30 August, when she joined William and Harry at an event to mark the 20th anniversary of the death of Princess Diana.
The couple were forced to announce that they were expecting their third child when she had to cancel a public appearance on 4 September due to sickness.
Kate also suffered from the condition when she was expecting Prince George and Princess Charlotte.
Normal morning sickness affects about 70% of pregnant women and causes some degree of vomiting and discomfort normally in the first trimester (12 weeks) of pregnancy, but those suffering from hyperemesis gravidarum can be constantly sick throughout the day.
So far, no further royal engagements have been announced for the Duchess of Cambridge and its understood this appearance does not mean she will be resuming full royal duties just yet.


Whether you've decided to combat the signs of aging or you just want to see the world more clearly, you've decided on a more confident you through cosmetic eyelid surgery.
Now what? Who goes on this journey with you, and what can you expect?
A cosmetic eye procedure shouldn't be a guessing game; you should feel confident and relaxed, knowing that you're in the best of hands, and that all your questions have been answered.
Use our guide as a checklist, and know that you've made an informed decision.
-How many years of training did you receive?
-How many times have you performed this procedure? Over how many years?
-Are there any alternatives to this procedure?
-Who will assist with the procedure? What are their qualifications?
-Where will the procedure be performed?
-What exactly does the procedure involve?
-Do you have hospital privileges? Where?
-What type of anesthesia will be used?
-How long will the procedure last?
-How long will the effects of sedation last?
-How long will it take to recover?
-What will be expected of me to get the best results?
-What are the risks associated with the procedure?
-What options do I have if I'm dissatisfied?
-What warning signs can I look out for after the procedure?
-Who can I contact if I have concerns after the procedure?
-Can I see before and after pictures of previous patients of this procedure?
-Can you provide patient references?
-What is the cost for the procedure, and what do the costs consist of?
Orlando's Cosmetic Eye Surgeon Dr. Haas's qualifications speak for themselves: he's performed over 10,000 eyelid surgeries, over 5,000 cataract surgeries, and over 5,000 ophthalmic laser procedures.
Have more questions? Just pick up the phone and call us at 407-841-1490, or make an appointment online and we'll be happy to answer them.


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Home›About›Possibility People›Mike - Bokeh Development
Downtown Wichita > About > Possibility People > Mike - Bokeh Development
Bokeh Development
When orthopedic physician assistant Michael Ramsey sent his children to college on the condition that they choose universities located in diverse urban areas, he didn't know it would change his life too. The plan to broaden their horizons beyond an upper-middle-class Midwestern childhood worked — until he realized they didn't consider their hometown a viable option for living and working after completing their studies.
"They said, 'Dad, we can't live in Wichita,'" Ramsey shares. "'We'd have to buy a car, live somewhere less cool than we are now — basically go back on everything you taught us.' Wichita has had a hard time competing with larger metropolitan areas because we weren't offering downtown living."
Ramsey saw the challenge as an opportunity and formed Bokeh Development with his long-time business partner and medical colleague, surgeon Robert Eyster. The two began pursuing projects that allowed them to contribute directly to a new vision for Downtown. People often ask how Ramsey transitioned from orthopedic surgery to urban development. He says the two fields are more similar than they first appear.
"Orthopedics is about building good foundations," Ramsey said. "In medicine, we're building knees and hips and ankles, when we translate that to construction, we're still looking at what we can build on."
Even the name of their company captures the unique perspective of their investments. "Bokeh" is the Japanese photographic term for the aspects of an image that are out of focus — the blurred edges where light and color aren't quite defined.
"We try to find value and interest in things that aren't in focus for most people," Ramsey explains. "We try to see the possibilities and enhance the areas around us. Even if we're not going to develop that building right now, we put in a placeholder that adds something to the space."
For example, the Pop-Up Urban Park converted a bare construction site into a temporary community gathering place while more permanent plans are under development. Working alongside researchers and community leaders, following the guidelines of the city's Master Plan, Bokeh's projects capture the energy of Downtown, targeting key zones for growth.
"We're really trying to set anchors," Ramsey said. "We are always thoughtful with our progression."
The Lux, Renfro, and Zelman Lofts offer apartments or condos with main-floor commercial spaces. The COrTen building houses several offices with a shared conference room. Plans are in progress to remodel the historic Broadway Autopark into unique residences and offices. A data-driven investor, Ramsey understands that his dreams must function within reality, so he keeps his inspirations close at hand.
"That's why I moved Downtown," Ramsey explains. "There's nothing better than being at eye level to understand the nuances of a place. We benefit from the success of these businesses when we listen and respond to their needs."


Ground and Project Consultants offers a range of ground engineering and environmental consulting services to businesses across the UK.
Director Jon Smithson has 30 years' experience in geotechnical and geo-environmental engineering, having worked on and led a number of complex multi-disciplinary engineering and environmental projects.
Jon draws upon a select group of associates who reinforce and complement his own skills, allowing Ground and Project Consultants to tackle a wide range of complex projects.
We recognise that many projects are not one-dimensional and the ability to bring in a range of geological and environmental skills gives our clients the benefits of a full service delivered by highly experienced professionals.
Jon's experience includes the remediation of the Avenue Coking Works in Chesterfield, one of the most challenging and complex regeneration projects in the UK.
Jon's experience with both SME's and large multi-national consultants both in the UK and abroad have given him a unique insight into the ground engineering and land quality business.
Ground and Project Consultants works with a number of leading independent experts in the fields of geotechnics, contaminated land, hydrogeology and environmental consultancy and can offer teams to provide clients a comprehensive service.
Dave Cooke offers a strong compliment to Jon in the field of contaminated land and regeneration with excellent risk assessment skills, as well as offering a Scottish perspective and greater geographical reach.
Groundwater plays a key role in many civil engineering, development and regeneration projects as well as being a valuable resource to many of our clients, making Hannah's skills a valuable asset to G&PC.
Waste issues are often inextricably linked to development and contaminated land regeneration projects and Clare brings strong technical abilities and excellent knowledge of regulation and regulators.
Peter's in depth skills in geotechnical engineering and engineering geology provide Jon with a strength in depth with over 60 years' experience between them. Peter has particular strengths in mining and mine wastes, tunnelling, earthworks and retaining structures.


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Q: Unable to parse date format in Javascript I'm working with D3 and am trying to parse the following date format
2013-06-16T07:00:00+0000

I've tried using the following code to parse it properly but it doesn't work:
var parseDate = d3.time.format("%Y-%m-%d%H:%M+%S").parse;

I can't seem to properly decipher the formate in order to parse it. Does anyone know the proper way to write this date format?

A: That format is ISO8601 / RFC3339, and is only supported in newer browsers.  See here for a list of browsers that support it natively.
Usually, my recommendation would be to use moment.js.  But since you are already using d3, you should look at their reference for time formatting.
Looking at your string, it appears you just have the format string wrong.  Do this instead:
var dt = d3.time.format("%Y-%m-%dT%H:%M:%S%Z").parse('2013-06-16T07:00:00+0000');

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According to Small Business Trends, more than 50 percent of small businesses fail the first four years.
To succeed you need to have a business plan that includes every aspect of how you will run your operation. Another essential element is research; you will have to do lots of it before spending money.
Furthermore, you should not assume that you will get financing other than the money you start with from yourself, family and friends. Only a tiny percentage of start-ups get Venture Capital (VC) funding.
The most important aspect, however, is the team. Do not think that you can do this alone. Nevertheless, you have to select your team members carefully and add as much diversity as possible.
To have significant success as a startup, you will have to master all the do's and don'ts. Also, a start-up is a seven-day-a-week occupation. Do not assume you are leaving a nine-to-five job for the smooth and flexible life of being your own boss.


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Kelp Wanted
Call it the kale of the sea: seaweed and kelp, the abundantly available, super nutritious marine vegetable. Supermarket retailer, Whole Foods, named seaweed part of its predicted healthy food trends list for 2019, and it's no wonder: it's packed with vitamins A, C, K, B-12 and minerals including calcium, iron, zinc and iodine. Not only are seaweeds vital to marine ecosystems (refuge, feeding and spawning for marine mammals as well as trapping sediment), they can also be sustainably harvested right here in the Pacific Northwest and enjoyed at home.
Turkish Towel seaweed, one of the red algae found on the Pacific Coast. Photo: Jerry Kirkhardt, Wikimedia Commons
Seaweed is broken into three marine algae categories: red, green and brown (the latter includes kelp). One of the best ways to learn how to collect and enjoy Pacific Northwest seaweed is to follow the experts' leads. Take a field trip and immerse yourself in the Salish Sea shoreline.
May 18: Chris and Kim Chisholm offer hands-on discovery through their Wolf College conservation workshop Edible Seaweeds and Shellfish of the Salish Sea, held from 10:30 a.m. to 5:30 p.m. on Whidbey Island during a remarkable minus-three-foot tide ($95 per adult, $90 per additional adult). Chris Chisholm notes the class foci breaks out like this, 40% seaweed, 40% shellfish and 20% shoreline plants. After a day of identification and harvest, the class moves into preserving, preparing and cooking wild edibles on site. To register, call 425-248-0253 and view the full itinerary here.
June 16-19: Earthwalk Northwest presents Seaweeds and Coastal Foraging, a four-day intensive workshop in the San Juan Islands ($445). Details here.
June 23, 10 a.m.- 2 p.m.: Earthwalk Northwest offers a Cooking with Seaweeds class focused about identification, harvest methods, and preparation of the most beneficial local seaweeds ($95). Details here.
Also, in Rockaway, Oregon:
May 17-20: expert and author John Kallas facilitates a Native Shores Wild Foods Rendezvous focused on "wild harvested sea vegetables, shellfish and coastal edible wild plants in everyday life, recreational foraging, re-connecting with nature, self-reliance and survival" ($360). Details here.
Oregon-based guide John Kallas showing sea lettuce. Photo: Leslie Seaton, Wikimedia Commons
If you harvest, know the rules
First, have a Washington state shellfish license anytime you plan to harvest seaweed. There are a few license options at wdfw.wa.gov. The basic Washington Department of Fish and Wildlife rules on seaweed collection are fairly broad. City and county parks may have their own closures, plus you'll want to avoid outflow areas and potentially polluted areas or heavy shipping lanes. Private waterfronts with owner permissions and natural resource lands are allowed, just make sure the areas are free of marine toxins (more information below).
Generally speaking, all species of seaweed can be harvested year round. The where and how become the bigger questions. State parks are extremely limited on seaweed harvests, but right now, you're in luck! From April 16 to May 15, 2019, Fort Flagler, Fort Ebey and Fort Worden State Parks are open to seaweed harvests during posted park hours. For kelp specifically, bull kelp must be cut a minimum of 24 inches above the bulb and short-stemmed kelps must be cut a minimum of 12 inches above the anchor point. The anchor point must be left in place at all times. Only a knife or similar instrument may be used to harvest. Tearing the plant and using tined instruments such as rakes or forks is prohibited. Each harvester must use his/her own container (no combing!) and must use a scale to weigh for limits. Weights must be wet only, no dehydrated or partly dehydrated weights are allowed. It's also illegal to harvest any seaweed if herring eggs are attached. More info here: https://wdfw.wa.gov/sites/default/files/publications/01998/2018-19_shellfish.pdf
Sargassum (hijiki) is found all over the world, including the Salish Sea. It's a type of brown algae. Photo: Philippe Bourjon, Wikimedia Commons
With a 10-pound-per-day wet harvest limit, even a one-day haul can go a long way in a personal kitchen. All clean seaweed is technically edible and most seaweeds can be enjoyed raw, but some seaweeds offer superior texture, flavor and nutritional benefits over others. Be careful not to overindulge. Too much iodine in select types of seaweed, for example, can affect thyroid function, so it's important not to exceed dietary guidelines. To illustrate, a tablespoon of seaweed added to a bowl of miso soup can provide a full daily allowance of iodine.
Sugar Wrack Kombu (sugar kelp) at Golden Gardens. Photo: Brewbooks, Wikimedia Commons
The Washington State Department of Natural Resources offers an easy-to-understand seaweed harvest brochure here or at https://www.dnr.wa.gov/seaweed. Check for the water quality and marine toxicity of public beach shellfish and seaweed harvesting areas through the Washington State Department of Health here.
In addition to the immersive classes mentioned above, one can read up on the region's edible shorelines:
Field Guide to Seaweeds of the Pacific Northwest, Bridgette Clarkston
Pacific Seaweeds: A Guide to Common Seaweeds of the Pacific Coast—Updated and Expanded Edition, Louis Druehl and Bridgette Clarkston
Enjoy spring on the shoreline, and perhaps never look at seaweed the same way again!


Published at Saturday, April 20th, 2019 - 1:04 PM. 3 Wiring Diagram. By Steven G. Rios.
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Online event registrations for bus tours are now open. Remaining seats (if any) will be listed under each event online. Once registration closes, remaining seats will be filled on a first come first serve basis the day/time of the event. Payment for walk-ons is cash only. Thanks for your interest in the festival – looking forward to another great event!
Tenting area or camper parking is available at Marsh Haven Nature Center, located on the northwest corner of the Horicon Marsh (Highway 49), during the Horicon Marsh Bird Festival. Facilities include: Pit toilets, potable water, and shared campfire area/picnic shelter. $10/night for tents, $15/night for campers.
Call (920) 324-5818 or email director@marshhaven.org for more information or to make reservations or visit www.marshhaven.org/birdfest for online reservations.
Your trip leaders will be DNR Wildlife Educator, Liz Herzmann and Dodge County Wisconsin Breeding Bird Atlas coordinator, Matt Herzmann. We will start at the south entrance of the Horicon Marsh Education and Visitor Center (Location A) and board a bus at 3:30 PM SHARP. We will bird some of the better habitat locations in and around Horicon Marsh and do some early scouting for the festival. This will be a fantastic opportunity to explore areas of the marsh before the festival and hopefully catch an early rarity or two! Registration with payment required.
This is an all-day, two-part tour by bus and pontoon boat. Your tour guides will be Daryl Tessen, Pat Horn, and Jeff Bahls. We will start at the south entrance of the Horicon Marsh Education and Visitor Center (Location A) and board a bus at 6 AM SHARP where we will bird some of the better habitat locations in and around Horicon Marsh. In the afternoon, we will "walk the plank" boarding at Blue Heron Landing (Location C), Hwy 33 at the bridge in downtown Horicon. Captains Marc Zuelsdorf and Jerry Genzmer will be your guides for this part of the tour. The boat departs at 3:00 PM SHARP from Blue Heron Landing. Our main objective is to ID as many bird species as possible. Short hikes will provide easy walking and we will "try" to stay on dry ground. A box lunch & drink are included in the cost of this tour. Registration with payment required.
Watch a Refuge video, view interactive displays, observe the marsh from the viewing deck with spotting scopes and visit the Refuge gift shop. Opportunity to view the Wisconsin Federal Junior Duck Stamp Exhibit. No charge for programs or activities. The Horicon National Wildlife Refuge Visitor Center, is located at: W4279 Headquarters Rd. off Cty. Rd. Z on the east side of the marsh.
Many of the Bird Festival events will begin at the Horicon Marsh Education and Visitor Center. This center is a $4.8 million project made possible largely due to tremendous local support. The center features an auditorium, two classrooms, gift shop and a spectacular view of Horicon Marsh. Brand new exhibits called the Explorium opened in August of 2015. We hope you enjoy these exciting, interactive displays!
Volunteers will be on hand to provide information and direct visitors to the many events. Maps, festival schedules and other handouts will be available. Bird Festival pins, hats and shirts will be on sale and the gift shop will be open for those interested in purchasing something to remind them of their experience. We have a few festival pins available from previous years for those who forgot to purchase one at the time or for collectors. The Horicon Marsh Education and Visitor Center is located off of Hwy. 28 between Mayville and Horicon.
Walk through the museum displays depicting the history and wildlife of the Horicon Marsh area. Walk the trails, visit the observation tower, browse the gift shop, and enjoy an opportunity to observe Marsh Haven's purple martin colony. Marsh Haven Nature Center is located at: W10145 Highway 49, on the north end of the marsh, just east of Waupun. Open 12:00 to 4:00 pm weekdays and 9:00 am to 5 pm weekends.
Your hike leader will be Liz Herzmann. This program will introduce binocular and field guide use and bird identification. A short bird hike will accompany the program. The hike may be on uneven trails, but they are rated easy. This is for ALL ages that want to learn more about birding. Meet at the Horicon Marsh Education and Visitor Center, off of Hwy. 28 between Mayville and Horicon.
Join Marsh Haven Nature Center director, Renee Wahlen, as we hike the nest box trail. This easy hike will include frequent stops to monitor some of the 40+ nest boxes at Marsh Haven. We will record our discoveries and learn more about what birds are building nests and raising their young at the nature center.
Your tour guide will be USFWS staff for this unique dusk into dark tour of critters that sing, call, and dance as the sun sets and night falls on Horicon Marsh. The tour begins at Marsh Haven Nature Center. With special permission from the U.S. Fish and Wildlife Service, we will take a bus on the Auto Tour loop at dusk and stay AFTER DARK. The bus will make stops to get out to hear and see the Woodcock dance and to listen to songs and calls of the marsh's nocturnal birds and amphibians. Conditions permitting, we will take a short walk down Old Marsh Road and the Boardwalk to enjoy the night sky and experience a new perspective of the marsh at night. Long pants and sleeves are recommended as well as closed toed shoes. Bring a flashlight if you wish.
Meet at Marsh Haven Nature Center at 7pm.
Join Horicon Marsh Bird Club members for a unique way to bird watch!
From 4 AM to 6:30 PM we will identify as many bird species as possible from a 17-foot circle on the Observation Deck at the Palmatory Street Overlook. Come and join us for all or part of this annual event as we try to ID every bird seen and/or heard from this location.
The Observation Deck has great views of the cattail marsh, open water, grassland, shrubbery and trees and give this location a high mark for species potential. We've averaged 79 bird species during previous Big Sits and have a total species list of 112 from this Observation Deck over the last 4 Festivals. Feel free to check-in throughout the day to see where our count stands.
Donations are greatly appreciated; as this is our main funding source for Club projects and the fun and educational Bird Festival. There will be a donation box located on the observation deck during the Big Sit. Donations can also be made on our website.
Please note: All or parts of the event will be canceled if there is bad weather.
This is a field trip designed for birders who want to add as many species as possible to their bird lists. Field trip leaders are Brad Webb and Marty Evanson. Be prepared to move by bus from location to location in search of migratory hot spots. There will be some walking but it is rated easy. We try our best to finish on time, but in the world of birding, bird activity is the deciding factor. Meet at the Horicon Marsh Education and Visitor Center, off of Hwy. 28 between Mayville and Horicon. Please use the lower entrance on the south side of the building. Bus departs at 6:00 AM SHARP. Bring your own snacks.
Join Jeff Bahls and Greg Seegert on a guided birding bus tour across 3+ miles of the interior of the refuge via Old Marsh Road. A reconfigured route this year visits many of the normal hotspots that have been your favorites for so long, but this year we will be able to travel Old Marsh Road by bus. We will start at Horicon National Wildlife Refuge headquarters and begin with some grassland, marsh and forested sections along the way to Old Marsh Road.
This is a unique opportunity to travel an area of the marsh that is closed to public access during this time of the year. Viewing highlights include many species of water birds, spring warblers etc. Wear good walking shoes. Meet at the Horicon National Wildlife Refuge Visitor Center, W4279 Headquarters Rd. off Cty. Rd. Z on the east side of the marsh. The bus will depart at 6:00 AM SHARP. Bring your own snacks. Registration with payment required.
With the cooperation of the USFWS, a portion of each registration fee is being donated to the Friends of Horicon National Wildlife Refuge.
Join UW-Oshkosh professor, Sheldon Cooper, to see our migrating songbirds close up and in the hand as they are captured, banded and released for study. Enjoy warblers, catbirds, sparrows and more! This is a public demonstration where visitors will be able to see how and why bird banding is conducted. It also provides one of the best opportunities to observe these amazing migrants up close.
Dr. Cooper's interests are in thermoregulation and ecological energetics of songbirds, particularly chickadees and titmice. He has published many articles related to physiological changes in nonmigratory songbirds that are important for overwinter survival. Dr. Cooper served as the Wisconsin Society for Ornithology Research Chair from 2006-2009.
Meet at the Palmatory Street Overlook, North Palmatory St. in Horicon.
Join leaders for a hike that will focus on bird species along a boardwalk reaching out to Indermuhle Island through the marsh and covering a variety of habitats. Walking on uneven trails and in damp foliage is a possibility. Meet at the Horicon Marsh Education and Visitor Center, off of Hwy. 28 between Mayville and Horicon.
Bigby (Big, green, bird year). Green birding is birding done without the use of fossil fuels and/or the internal combustion engine. Green birders are self-propelled birders, e.g., walking, riding a bicycle, paddling a canoe or kayak, or using skis or snowshoes.
Join Dodge County's Breeding Bird Atlas Coordinator, Matt Herzmann for a bike ride of about 10-15 leisurely miles to some local birding spots around Horicon. Bring your bike, biking stuff, (helmet, gloves, water bottles, etc.) and binoculars. Matt will cover basic rules of the road, then set off on a ride to several spots around Horicon.
We'll start at 8 AM and end about noon. Leave from Horicon Marsh Education and Visitor Center, Hwy. 28. Payment and registration required.
Walk through the museum displays depicting the history and wildlife of the Horicon Marsh area. Walk the trails, visit the observation tower, browse the gift shop, and enjoy an opportunity to observe Marsh Haven's purple martin colony. Marsh Haven Nature Center is located at: W10145 Highway 49, on the north end of the marsh, just east of Waupun. Open 12:00 to 4:00 pm weekdays and 9:00 am to 5:00 pm weekends.
Kid & Family activity. Pick up your scavenger hunt at the information table at the Horicon Marsh Education and Visitor Center and let your birdy adventure begin! Travel through the center and its surrounding trails to learn about extinct birds, where to look for birds, and how you can make a difference for birds. Once finished, return your paper and receive a cool bird prize!
Kid & Family Event. Join leaders for a hike that will focus on bird species along the Horicon Marsh Education and Visitor Center trail system; a boardwalk reaching out to Indermuhle Island through the marsh and covering a variety of habitats. Walking on uneven trails and in damp foliage is a possibility. Meet at the Horicon Marsh Education and Visitor, off of Hwy. 28 between Mayville and Horicon.
Take your birding knowledge to the "nest" level by learning to identify birds by nest! Join leaders for a walk that will highlight the differences in birds' nests by cracking open various nest boxes. Discover how to find out who's home and how to promote nesting in your own backyard. Meet in the lower lobby at the Horicon Marsh Education and Visitor Center, off of Hwy. 28 between Mayville and Horicon.
Grab a bite to eat at the Horicon Marsh Education & Visitor Center's Chili Lunch. Enjoy a relaxing meal while sitting inside the lower lobby of the visitor center or enjoy the day at any of the picnic tables surrounding the visitor center.
Chili Lunch proceeds benefit the Friends of Horicon Marsh Education & Visitor Center.
In between Bird Festival events, grab a bite to eat at Marsh Haven Nature Center's Birder's Brat Fry. Brats, beverages, homemade desserts and more will be served and offers an opportunity to enjoy lunch while watching the purple martins, yellow-headed blackbirds, and other birds that make an appearance over the weekend.
Karla Bloem, director of the International Owl Center in Houston, MN will be the featured speaker for the 2019 Horicon Marsh Bird Festival. She will be presenting on "Real Life Great Horned Owl Soap Operas"!
Meet in the auditorium of the Horicon Marsh Education and Visitor Center located on Highway 28 between the cities of Horicon and Mayville.
Your hike leader will be Liz Herzmann. This program will introduce binocular and field guide use and bird identification. A short bird hike will accompany the program. The hike may be on uneven trails but they are rated easy. This is for ALL ages that want to learn more about birding. Meet at the Horicon Marsh Education and Visitor Center, off of Hwy. 28 between Mayville and Horicon.
Have you ever wanted to see a hawk or owl close up? This program will introduce some of Wisconsin's raptors through a photo presentation, mounted specimens, and LIVE birds. These are educational birds and cannot be returned to the wild due to a variety of permanent injuries. The particular live birds may vary by program, but may include a Red-tailed Hawk, American Kestrel, Great Horned Owl or Barred Owl.
Trip leader Jeff Bahls will be using the knowledge obtained from other festival field trips in finding various birding locations (Hot Spots) in hopes of adding as many species as possible in the time allotted. We may even strike out on our own to a new birding spot not included in this year's festival! Walking on uneven trails is possible. Meet at the Horicon Marsh Education and Visitor Center, off Hwy. 28 between Mayville and Horicon. Please use the entrance on the south side of the building. Bus departs at 4:30 PM SHARP. This event will be held again on Sunday. Registration with payment required.
Join your fellow festival goers and bird buddies at "The Rock". Compare sightings and celebrate life birds.
The Rock River Tap has been a local hangout for decades. It features a nice deck along the shores of the Rock River, 6 beers on tap and a great food menu. Visit www.rockrivertap.com.
Your tour guide will be USFWS staff, for this unique dusk into dark tour of critters that sing, call, and dance as the sun sets and night falls on Horicon Marsh. The tour begins at Marsh Haven Nature Center. With special permission from the U.S. Fish and Wildlife Service, we will take a bus on the Auto Tour loop at dusk and stay AFTER DARK. The bus will make stops to get out to hear and see the Woodcock dance and to listen to songs and calls of the marsh's nocturnal birds and amphibians. Conditions permitting, we will take a short walk down Old Marsh Road and the Boardwalk to enjoy the night sky and experience a new perspective of the marsh at night. Long pants and sleeves are recommended as well as closed toed shoes. Bring a flashlight if you wish.
During the day, Horicon Marsh is a relaxing and tranquil place to enjoy nature. But the dark mysteries of the marsh at night can be "chilling" to those not accustomed to the sounds of nocturnal creatures. Hike leader Liz Herzmann will dispel the myths of the night as she helps you identify the many nocturnal sounds that come from within the cattails. This program will be conducted outside with easy walking but possible uneven terrain, so remember to dress warm and bring a low powered flashlight. Meet at the Horicon Marsh Education and Visitor Center, off of Hwy. 28 between Mayville and Horicon. Please use the lower entrance on the south side of the building.
Designed for birders who are less concerned about checking a bird off their list quickly and more for the longer looks at these colorful migrants. Although we will still try to see a large number of species, this tour will focus on slower paced birding with a focus on habitat, behavior and field identification. Your tour guides will be Jeff Bahls and Brad Webb.
Meet at the Horicon Marsh Education and Visitor Center, off of Hwy. 28 between Mayville and Horicon. Please use the entrance on the south side of the building. Bus departs at 6:00 am SHARP. Registration with payment required.
Pick up your scavenger hunt in the lower level of the Horicon Marsh Education and Visitor Center and let your birdy adventure begin! Travel through the center and its surrounding trails to learn about extinct birds, where to look for birds, and how you can make a difference for birds. Once finished, return your paper and receive a cool bird prize!
In-between Bird Festival events, grab a bite to eat at Marsh Haven Nature Center's Birder's Brat Fry. Brats, beverages, homemade desserts and more will be served and offers an opportunity to enjoy lunch while watching the purple martins, yellow-headed blackbirds, and other birds that make an appearance over the weekend.
Join Rick Vant Hoff for a program of stunning photography and stories of his travels in search of birds. From Steller's jays in Colorado to a peregrine falcon on the Horicon Marsh, Rick has toured the countryside and documented his travels with beautiful nature photography. Rick is a member of the Horicon Marsh Bird Club, on the Board of Directors at Marsh Haven Nature Center, and volunteers at the Horicon Marsh Education & Visitors Center.
Learn about the amazing adaptations of owls – how they hunt, how to identify each species by their vocalizations, and other fascinating facts. This program includes a photo presentation, mounted specimens, and LIVE owls. These are educational birds and cannot be returned to the wild due to a variety of permanent injuries. The live birds may include an Eastern Screech Owl, Great Horned Owl or Barred Owl.
Have you always wondered what was inside an owl's "hairball?" Are you searching for a unique experience for mom on Mother's Day? Give her the gift of owl regurgitate this year! During this all-ages program, we will discover what local owls are eating through hands-on pellet dissection. Meet in the lower lobby at the Horicon Marsh Education and Visitor Center, off of Hwy. 28 between Mayville and Horicon.
Trip leader Jeff Bahls will be using the knowledge obtained from other festival field trips in finding various birding locations (Hot Spots) in hopes of adding as many species as possible in the time allotted. We may even strike out on our own to a new birding spot not included in this year's festival! Walking on uneven trails is possible. Meet at the Horicon Marsh Education and Visitor Center, off of Hwy. 28 between Mayville and Horicon. Please use the entrance on the south side of the building. Bus departs at 4:30 PM SHARP. This event is also held on Saturday. Registration with payment required.
This is an all-day two-part tour by pontoon boat and bus. Your tour guides will be Jeff Bahls and Sarah Warner. We will start with a pontoon boat tour at 6am SHARP, we will "walk the plank" boarding at Blue Heron Landing (Location C) Hwy 33 by the bridge in downtown Horicon. Captains Marc Zuelsdorf and Jerry Genzmer will be your guides for this part of the tour. After the boat tour, we will gather at the Horicon Marsh Education Center (Location A) and board the bus for the rest of our tour, birding some of the better habitat locations in and around Horicon Marsh. Our main objective is to ID as many bird species as possible. Short hikes will provide easy walking and we will try to stay on dry ground. A box lunch and drink are included in the cost of this tour. Registration with payment required.
Join local birder/photographer, Rick Vant Hoff, on a walk along Waupun's Rock River Boardwalk. This lovely nature trail walk may reward you with the sighting of thrushes, thrashers, woodpeckers, and a variety of warblers. The Rock River may also provide opportunity to see egrets and herons.
Meet at Marsh Haven at 7:30am to carpool/caravan into Waupun.
Your hike leader will be Liz Hermann. Ziegler Park has 72.3 acres of parkland; a majority of it is wooded with a 1.5 mile nature trail along the Rock River. A large variety of birds can be seen in this natural habitat. Bird houses are added whenever possible by the community. This can be a warbler hotspot with over 15 species being seen on a good day. Join us to search for the colorful woodland warblers!
Get a close up look at the Marsh Haven Nature Center purple martin colony. See their housing, check out the "martin cam", view the record keeping, and find out what goes into being a purple martin landlord.
For the past 50 years, Horicon Marsh Boat Tours has been helping you experience one of America's great natural treasures. Whether you're an avid birdwatcher, an inquisitive nature enthusiast or just someone who's curious about the Horicon Marsh, you need to take a pontoon boat tour. You'll be led by the Horicon Marsh's most knowledgeable guide, who will reveal to you the marsh's birds, wildlife and significant ecological features. For those who want a more solitary marsh experience, Horicon Marsh Boat Tours rents canoes and kayaks. Since 1963, Horicon Marsh Boat Tours has been a family-owned business noted for our commitment to the environment and dedication to protecting the marsh. We are Wisconsin Travel Green certified. Tours are offered from May 1 through late October. Call and reserve your space on the boat today and enjoy a truly unforgettable experience.


More public and private establishments are investing in electric vehicle charging stations and other alternative fueling sources, such as biodiesel and ethanol. The number of alternative fueling stations has steadily increased in the past 8 years. With this charging station influx, it is more viable to own an electric vehicle in the coming years. This widget calculates potential electric vehicle savings.


Two-thirds of museum directors say their boards have a positive impact on their job satisfaction.
Museum boards give themselves a B- grade overall, on par with other nonprofits; however, the vast majority of museum boards do not formally assess their performance.
Museum directors and board chairs believe board diversity and inclusion are important to advance their missions but have failed to prioritize action steps to advance these priorities.
Eighty percent of museums give themselves a grade of C or lower on monitoring legislative and regulatory issues with the potential to impact the organization.
Museum board chairs are actively engaged in fundraising activities and identified fundraising as the most important area for improvement.
A panel of museum leaders—both directors and board chairs—discussed the report and its findings May 8, 2017, at the inaugural Trustee Summit at the AAM Annual Meeting & MuseumExpo in St. Louis.
Questions? Contact Brooke Leonard, Chief of Staff, at 202-289-9139 or email bleonard@aam-us.org.


The last time I blogged on here was March.
Looking back it all makes sense but at the time it was a lot of 'I'll do it once I'm done with this one thing." and then I'd have a new one thing and the cycle would start all over again. The things are a bunch of courses on data science, drones and web development (because why not). There was also lots of travel and then to top it off my ideas for this project changed with every new experience.
But in the meantime, I built a thing with the new skills. I scraped various websites (massive shoutout to Ann Morgan), cleaned up the data, setup the database, and built a random book generator.
It's nothing special really. Basically, when you press the orange 'Travel' button at the top you get a book from a different country.
I'm thinking the next feature should include Amazon links for easy purchasing. Ideally proceeds would go to a special cause but I have to figure out the logistics behind that.
Mekatelyu or Limon Creole/Patois. The name is a transliteration of the phrase "make I tell you", or in standard English "let me tell you". Though sometimes referred to as Limon Creole English, I recently learned that it's not always comprised of only English words.
The first wave of Black arrivals in the form of slavery.
The second wave of Black arrivals through the United Fruit Company.
Recent efforts by the government to show appreciation for the community's contribution.
And if I'm lucky — what celebration day looks like (a few images from 2017 below courtesy of TicoTimes).


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North Bridge
EH11YT
Edinburgh Area
New Town, Edinburgh
Old Town Edinburgh
North Bridge is one of Edinburgh's main bridges connecting the New Town at its North end and the Old Town to the South. The road and pedestrian bridge rises above Edinburgh's main railway station, Waverley Station.
Built between 1894 and 1897, the bridge is 525 feet (160m) in length and 75 feet (23 m) wide.
West Parliament Square
East Princes Street Gardens
Stone of Remembrance
Parliament Square
The Royal Botanic Garden
Arthur's Seat
Festival Wheel
Foxlake Adventures
Mound Precinct
Charlotte Square Garden
Levenhall Links


Looks like I'm the first one to post here in English.
Tried registering a couple times at Forum.DashCamTalk.com, but no response from them.
Posted a question via BlackVue's "Contact Us" page several days ago. But there was no automated acknowledgement and no reply.
Just got this device a couple of days ago.
The box says "Full HD BLACKVUE Wi-Fi DR500GW-HD".
Files created have names beginning with "1969..." and "1970....", but it's 2013 around here.
When I try to HTTP into 192.168.8.1:80, no web page opens. From what I've heard, there should be a page.
When trying to use the Android app, it works maybe 1 out of 10 times. The rest of the times I get "Login Failed!".
The App successfully connects, and checking signal strength on Android's WiFi manager, I see 100% - but "Login Failed!".
My first thought is that it is DOA, but if you take everything I know about dashcams, roll it into a ball, and set it on the edge of a razor blade, it will look like a golfball in the middle of an AutoBahn.
I've seen a few references to SD cards causing problems that I would not think they could cause.... but my problems recur using two different cards, both formatted/initialized by the cam.
Has anybody got an idea of what might be wrong?
Re: 500HD, Stock Firmware, Mulltiple Anomalies: Is It DOA?
You can have at once some problems together. I advise to you in the beginning to try to reflash official firmware.
Further. GPS works for you in general or not?
Can anybody recommend a source for the original firmware. I have never flashed this device to begin with.
I am not sure whether the GPS is not working or the firmware is misinterpreting the GPS' information.
Just reviewed some clips from today some of the freeway cruising speed looked about right.
But most of the clips showed "049MPH" - even when the vehicle was stopped and especially in variable-speed traffic... it was always "049MPH".
It seems that you have troubles with GPS.
Please, re-flash the stock firmware as ave123 has suggested, and check once more how does your DR500GW works.
1. Return your DR500GW for a repairing by a guaranty.
2. Try to install a custom firmware available at this forum. The web page you mentioned will make few options available then. There is a procedure to reset a GPS module that may help.
3. Disassemble your DR500GW, and check the GPS battery (it may require to be replaced).
4) Return the thing to Amazon.com and buy another make/model.


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Desvio de conduta ou  é caracterizado por padrões persistentes de conduta socialmente inadequada, agressiva ou desafiante, com violação de normas sociais ou direitos individuais. Com cerca de 1 a 10% de prevalência em crianças e adolescentes, é um dos transtornos psiquiátricos mais frequentes em jovens e um dos maiores motivos de encaminhamento ao psiquiatra infantil.

Causas

O ambiente familiar e social tem papel importante no desenvolvimento e manutenção de transtorno de conduta. O comportamento de oposição e desobediência está associado a pais e irmãos agressivos e negligentes, divórcio dos pais, grandes famílias, mães jovens, baixa condição socioeconômica, apenas um cuidador.

Em adolescentes com transtorno de conduta pode-se identificar uma baixa responsabilidade na área orbitofrontal área responsável pelo processamento de estímulos de recompensa. Pode ser causa e consequência de um histórico de aprendizagem em que prevaleceram punições pelos maus comportamentos em vez de reforço pelos bons comportamentos. De forma similar, a amígdala cerebelosa responde menos a estímulos de intimidação e medo, podendo tanto ser o motivo por não evitar estímulos aversivos que a maioria evitaria ou/e por ter se acostumado a viver em um ambiente intimidador e ameaçador.

É importante estar alerta ao comportamento dos pais, pois transtornos de conduta podem indicar histórico de abuso sexual e violência, alcoolismo e abuso de drogas na família.

Diagnóstico
Essas violações não atendem às expectativas sociais próprias à idade da criança, indo muito além de travessuras infantis ou de rebeldia do adolescente e continuam acontecendo regularmente por seis meses ou mais.

O diagnóstico se baseia na presença de:
Manifestações excessivas de agressividade e de tirania;
Crueldade em relação a outras pessoas ou a animais;
Destruição dos bens de outrem;
Condutas incendiárias;
Roubos ou furtos;
Abuso sexual;
Porte de armas;
Mentiras repetidas;
Cabular aulas e fugir de casa;
Desobediências anormalmente frequentes e graves.

Diagnósticos diferenciais
A presença de manifestações nítidas de um dos grupos de conduta precedentes é suficiente para o diagnóstico mas atos dissociais isolados não o são. Devendo-se diferenciar do transtornos globais do desenvolvimento (o autismo e suas variantes) dos transtornos humor (afetivos) e ainda diferenciado desses processos quando associados a condições ou traumas emocionais e hiperatividade e transtorno do déficit de atenção com hiperatividade.

Caso esses comportamentos persistam após os 18 anos, passa a ser diagnosticado como transtorno de personalidade antissocial (psicopatia/sociopatia).

Epidemiologia
O transtorno da conduta é mais frequente entre os 12 e 16 anos, sendo quase 4 vezes mais comum no sexo masculino. Cerca de 20% também possuem algum transtorno de aprendizagem, como dificuldade em se concentrar, em se expressar oralmente ou na escrita ou de memória resultando em desempenho inferior à média na escola.

Tratamento

Assim como outras terapias com crianças e adolescentes o tratamento mais eficiente é o que inclui a família e a escola no processo. Também é recomendado que algumas sessões sejam individuais. Não é recomendado terapia em grupo com outros adolescentes agressivos, pois eles estimulam o mau comportamento uns nos outros. O tratamento também deve procurar resolver conflitos familiares, tais como divórcios destrutivos ou depressão materna.

Tratamentos isolados não demonstram eficiência, por isso é recomendado uma abordagem multiprofissional.

Não é recomendado que internações durem mais de 6 meses, penas alternativas como trabalho voluntário devem ser privilegiadas, e a família, quando disposta a colaborar e não tenha histórico de criminalidade, deve fazer parte de todas as fases do tratamento, sendo preparada e treinada para o retorno do adolescente.

Prognóstico
Quando aparece antes dos 10 anos indica maior gravidade do quadro e maior tendência de persistir ao longo da vida. Nesses casos geralmente está associado a transtorno do déficit de atenção com hiperatividade (43% dos casos), e a transtornos das emoções (ansiedade, depressão, obsessão-compulsão em 33% dos casos), comportamento agressivo, déficit intelectual, convulsões e comprometimento do sistema nervoso central devido a exposição a álcool/drogas durante a gravidez da mãe, infecções, uso de medicamentos ou/e traumas cranianos. Também é comum que existam antecedentes familiares de hiperatividade e comportamento antissocial.

Começo tardio (após os 15 anos), sexo feminino, QI alto, boas habilidades sociais, família melhor estruturada, boa relação com colegas na escola, não usar drogas, paciente mais jovem, cultura pacifista, boas condições financeiras e histórico familiar sem transtornos de personalidade estão associados a um melhor prognóstico.

Entre 60 e 75% dos adolescentes com transtorno de conduta não se tornam antissociais/psicopatas/sociopatas. A maioria nunca chega a ser condenada por algum crime e se tornam cidadãos produtivos desde que possuam apoio social suficiente.

Ver também
 Autismo
 Distúrbio do déficit de atenção sem hiperatividade
 Transtorno do déficit de atenção com hiperatividade
 Transtorno de personalidade antissocial
 Dificuldades de aprendizagem
 Comportamento divergente

Psicologia
Psicologia social
Neurologia infantil
Transtornos psíquicos
Perturbações emocionais e do comportamento na infância e na adolescência


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The Courage to Do Nothing
"Climate change is a non problem," says Lord Christopher Monckton, a UK climate researcher. "The right answer to a non problem is to have the courage to do nothing."
Of course, the 10,000 participants and observers at the United Nations conference on climate change are not there to "do nothing", if you discount the handful of skeptics who are there to rip back the curtain to reveal what a complete fraud is occurring.
The United Nations is not a stranger to fraud. The Iraq Oil for Food fraud helped enrich a number of its officials. Its indifference to genocides and human rights offenses is well established, but its love of treaties in which to increase its power over sovereign nations is also well documented.
The global warming "crisis" has been created and pushed forward by the United Nations in the form of its Intergovernmental Panel on Climate Change whose various reports are replete with deception. Dr. Vincent Gray of New Zealand, an expert reviewer of every single draft of the IPCC reports, going back to its inception in 1990, says, "There is no evidence that carbon dioxide increases are having any effect whatsoever on the climate. It fails not only from the data, but it fails in the statistics, and the mathematics."
On December 10, former Vice President Al Gore accepted a Nobel Prize for PEACE along with the IPCC. A panel of politicians, not scientists, awarded the prize. Moreover, what does the climate have to do with peace, unless perhaps one recalls that it was the Mini-Ice Age that drove Napoleon's troops from Russia in defeat or that America's Valley Force during the Revolution were also subject to conditions that caused even the Thames in London to freeze?
The Mini-Ice Age lasted from 1300 to around 1850. The earth has been warming ever since. It has nothing to do with human beings and everything to do with the Sun and other natural factors that determine the earth's climate.
The charlatans behind the latest UN conference are not there to "do nothing." They are there to impose limits on energy use that will have horrendous implications for any nation foolish enough to accept them.
The Kyoto Protocol needs to be allowed to expire. The world needs to do nothing about climate change because the human race can do nothing about climate change. Because the amount of carbon dioxide has nothing to do with climate change in that it follows a warming cycle, not precedes it. It changes nothing. It responds to change.
How difficult is that to understand?
Labels: Al Gore, environmentalists, global warming, united nations
Jeremy Jacobs said...
I don't find it difficult
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