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Pick up the phone: Lessons from the GOP's backtrack on ethics rules
Citizens' Climate Lobby > Be Your Best Advocate > Pick up the phone: Lessons from the GOP's backtrack on ethics rules
Posted on January 11, 2017 in Be Your Best Advocate
In response to the proposed weakening of the Office of Congressional Ethics last week, constituents across the country picked up the phone and called their representatives.
By Flannery Winchester
Last week, the 115th Congress got off to a dramatic—but important—start. Important not because of what the Congress did, but what the constituents made possible. Here's what went down: In a closed-door meeting last Monday night, House Republicans agreed to a proposal that would limit the capabilities of the Office of Congressional Ethics. The proposal was intended to be part of the rules package for the new Congress, and it would have brought the independent ethics office under the oversight of the House Ethics Committee, effectively compromising the OCE's independence. Also, according to Politifact, "Other provisions of the amendment would keep staff from speaking publicly without the House Ethics Committee's consent, prevent the office from investigating anonymous tips, and rename it the 'Office of Congressional Complaint Review.'"
Even if those changes had legitimate motivations behind them, it quickly looked bad in the press. One party gains power in the House, Senate and the White House, and its first order of business is to hobble a bipartisan, independent ethics group? It's tough to put a good PR spin on that.
By Tuesday, House Republicans were backing away from the proposal. It doesn't appear in the final rules package at all. So what happened?
Outpouring of organic advocacy
Well, you happened. We happened. A whole lot of public pressure happened. Brad Fitch, the president and CEO of the Congressional Management Foundation, has served on the Hill and worked as a researcher and consultant for Congress. He's seen these waves of public pressure arise before, he explained.
"I put them in two categories. There's what I call organic advocacy and directed advocacy. Most advocacy going to Capitol Hill is directed, meaning a group like the American Medical Association or the National Rifle Association sends an email out to their members, supporters or employees and says, 'Please forward this out to Capitol Hill.' Occasionally, every few years, we'll get organic advocacy."
At their staff meeting, the Congressional Management Foundation decided to do some digging and find out what advocacy type made the difference last week. "We talked to the congressional offices," Fitch said, and, "it sounds like it was a little of both, but it was mostly organic. The way we know is if people are usually talking off the same script, then it's directed—they have the same message and the same talking points over and over again. But in talking to congressional staff, we heard 'No, we just had a lot of cranky people calling us.'"
Trends spiked on Tuesday, as news spread of the proposed changes to the Office of Congressional Ethics. Image courtesy of Google Trends via Twitter.
The pressure was amplified by an avalanche of negative press and two tweets from President-elect Trump. But those factors can't take all the credit for the GOP's backtrack: Google showed a spike in searches for the phrase "Who is my representative" on Tuesday morning. Across the country, constituents were turning to Google to identify their reps, and presumably many of them followed through with a call to that representative's office—and a few choice words.
Be ready to act
"I think for CCL members, there's a lesson here," Fitch said. "The lesson is that you have to be nimble. You have to act quickly. We realize that people have busy lives, but this proves again that those people who are ready to act when action is required are the ones who win the day."
Not only are we ready to act now, but we've already been acting on the topic that is closest to our hearts: climate change. In 2016, CCL volunteers held at least 1387 meetings with representatives in Congress and wrote more than 40,000 letters to Congress. With last week's example in mind, we'll continue our respectful, persistent communication with all our representatives, knowing that it really does make a difference.
Tags:Congress
About Flannery Winchester
Flannery Winchester has put her words to work for magazines, for marketing agencies, and now for our earth as CCL's Communications Director. She is grateful to spend every day working to preserve this beautiful planet.
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©2022 Citizens' Climate Lobby. Citizens' Climate Education (CCE) is a tax-exempt 501(c)3 organization. Donations to Citizens' Climate Education are tax-deductible to the fullest extent of the law. Citizens' Climate Lobby (CCL) is a 501(c)4 organization. Donations to Citizens' Climate Lobby are not tax-deductible. 501(c)3 EIN 26-2948811 and 501(c)4 EIN 26-3521896.


7 Just then, Jacob's sons got back from the countryside. When they heard what had happened, they were outraged and very angry, because Shechem had disgraced Israel by sleeping with Jacob's daughter. Such things are simply not done.


Come and join our small friendly gliding club run by club members. We are located just south of Selby on the A19 and close to Junction 34 M62.
Originally the club was started in Doncaster in 1960 as Doncaster and District Gliding Club next to the race course. The Club relocated to the Ex RAF Burn airfield in 1984 where we have remained for the last 34 years.
We still have a few flying and social members from the Doncaster days. The club has a number of two seater trainer gliders and we recently refurbished our 1968 K13 two seater glider.
We have Aerotow and Winch launching available. We also benefit from thermals provided from the nearby power stations and have tarmacked runways, so we can fly all year round.


The introduction in the 1970's of wide bodied Airliners such as the 747 Jumbo saw the VC10 becoming uneconomical to operate which led to its withdrawal from passenger service. The final Commercial flight of a VC10 was on the 30th March 1981, by British Airways (the successor to BOAC) this ended the civil side of the story, but it certainly didn't end the story of the VC10 as its military Career with the Royal Air force was only just beginning.
having no need to replace the fuselage's fuel tanks. Overall, the conversion to the K4 variant was undertaken on five former passenger airliners.
Since the late 1990s, this type of aircraft took part in a variety of different scale conflicts in many parts of the world, including air strikes against Serbia, in the Second Iraq War (Operation Telic), and in air strikes against the Gaddafi regime in Libya. In 2013 the Royal Air Force made the decision to remove the VC10 from active service, having adopted the program of their replacement by the new A330MRRT tanker. Now the K4 tankers which were already considered obsolete have been completely retired from service, and sent for dismantling.


No statewide Michigan curfew law was found which specifies a curfew for juveniles.
Sec. 33-3-11. - Presence of minors on public streets, playgrounds, and other public places prohibited during certain times.
b.During daylight savings time: from 10:00 p.m. through 6:00 a.m.
a.During standard time: from 10:00 p.m. through 6:00 a.m., except Fridays and Saturdays: from 11:00 p.m. through 6:00 a.m.
b.During daylight savings time: from 11:00 p.m. through 6:00 a.m.
Sec. 33-3-12. - Presence of minors in arcades, bowling alleys, restaurants, theaters, and other places of amusement or entertainment during restricted times prohibited.
It shall be unlawful for a minor to be in an arcade, bowling alley, restaurant, theater, or other place of amusement or entertainment during the curfew periods as defined in section 33-3-11 of this Code.
Sec. 33-3-13. - Minors seventeen (17) years of age and under prohibited in billiard or pool halls, exceptions.
(b)Minors age seventeen (17). It shall be unlawful for a minor who is seventeen (17) years of age to be in or play billiards or pool in a billiard or pool hall during the curfew period defined in section 33-3-11 of this Code.
(c)Exceptions. The provisions of this section shall not apply to private residences, private clubs, schools, churches, duly-licensed family hobby and recreation centers, fraternal organizations, or any other civic agency, organization or institution.


This vacation farm in Drenthe is within walking distance of the Dwingelderveld national park, and offers a comfortable sleeping accommodation for 27 people. The authentic building is perfect for both adults and children. In the large private garden, you will find terraces and picnic tables. There is a separate play area with play facilities for children. There are also special facilities for people with disabilities.
"A lot of space, decorated for young and old, and very atmospheric," these are the typical reactions to this accommodation. You will have a pleasant stay in the nicely furnished common room (over 180 yd²) with a long bar, and the adjoining dining hall offers a lot of convenience. The new kitchen is fully equipped with professional catering equipment (oven, microwave, and dishwasher). Washing machine and tumble dryer are on request. Nine bedrooms, furnished with luxurious box spring beds, ensure a pleasant night's sleep. Furthermore, you have access to five showers and five toilets. Babies and toddlers are also catered for with cots, highchairs, playpen, changing table, kiddy pool, and stair gates, but also a small toddler corner. Children will have the time of their lives in the play area! In the park-like garden, there is a playground, and at 55 yd behind the vacation farm, there is a football field and a table tennis table. There is a separate room (for rent) with sauna and solarium, and there are fully adapted facilities for people with disabilities. The terrace has parasols. You park in your own car park.
The group accommodation is centrally located in Drenthe, within walking distance of the Dwingelderveld national park, and recreational lake Terhorsterzand. From the farm, you can go on bike tours, covered wagon tours, or even hiking tours with GPS in the beautiful nature reserve. The accommodation is also a great base for trips to Orvelte, Westerbork transit camp, Emmen Zoo, Planetron, the Hunebed museum or Kabouterland. Taribush Outdoor Activities organizes unique outings nearby. In the village itself, you can go klootschieten (ball throwing), bowling, or play mini golf, and there are restaurants for dinner or a quick bite.
Our guests rate this accommodation with an average of 8.5. On the side you will find the latest 11 reviews.
March 2019 - Families - Paul v.
Alles!!! Es war super schön und wir hatten eune tolle Zeit.
January 2019 - Families (with children) - Ute B.
January 2019 - Families (with children) - F E D.
Mooie omgeving. De boerderij was van alle gemakken voorzien. De kinderen vermaakten zich prima.
May 2018 - Families (with children) - F K.
September 2017 - Families (with children) - M. H.
Wij hebben met onze vriendengroep enorm genoten. Het is een mooie accommodatie met van alles meer dan genoeg zoals borden/bestek ed. Zelfs de "grote jongens"vonden de zolder met pooltafel en airhockey geweldig. Er gingen al stemmen op om hier nog een keer naar toe terug te gaan.
May 2017 - Friends - M. v.
Mooie boerderij. Mooie speel accommodatie voor de kinderen. Mooie rustige omgeving en wandelgebied. Professionele keuken. BBQ was zeer goed.
May 2017 - Families (with children) - Jeannette M.
Goed ontvangst en duidelijke uitleg. Bedden zijn goed en de keukeninventaris is zeer uitgebreid. Ligt dicht bij de bossen.
May 2017 - Friends - Wendy d.
April 2017 - Families (with children) - H W.


It's been a whirlwind 25 days on the Slightly South of Simple book tour, where I have had the great pleasure of meeting amazing people in beautiful cities and towns across our Country. I was in Atlanta just a few days ago, and I couldn't help but think about that time when I saw this fabulous Buckhead home designed by one of our favorite designers, Suzanne Kasler. Take a peek. We think you'll love it just as much as we do!
Don't forget Mom – we think Slightly South of Simple is the perfect gift!
The San Francisco Home of a Fashion Designer and More!
I love driving throughout the streets of Buckhead and seeing all of the amazing homes. This home is truly phenomenal. Love the interiors that of course would be so beautiful as designed by the wonderful Suzanne Kasler…The architectural details are truly exquisite! Thanks for the tour!
It's hard to top the work of Suzanne Kasler or the Buckhead area of Atlanta. When combined the results are fantastic!!!!
There's not a home that Suzanne has designed that we don't love… Her soothing colors, her elegant style and all of the little details are so lovely. We hope you'll have some time to enjoy your own home very soon! Hugs to Mom!
This Atlanta Segment is wonderful. The 'bones' of the home are exceptional; the architectural details awesome before we even look at furnishing it. And what a grand job was done on that! Stupendous.
Suzanne is the bomb! Thanks for sharing this beauty. Even the pool table room is exquisite!


Never been to a spoken word event? Make this your monthly chance to hear amazing beats and stories by a collection of talented writers.
On the first Saturday of every month we will provide you with tea, coffee, cake, amazing poetry, a supportive sense of community and the chance to dance!
10 open mic spots and 1 feature every month.


"The Perfect Complement to your CrossFit Lifestyle. Barbella Box is a monthly package filled with premium Functional Fitness apparel, gear, accessories, snacks, supplements, workout tips, and more exclusively for women! Each month, discover a healthy mix of 4-6 well-known and new-to-the-market brands in the CrossFit market. Hand picked by women for women."
How do you rate Barbella Box?


Behind Mon Bijou there is a beautiful idea. "Mon Bijou" was launched by a group of people from the fashion industry. Some profits from "Mon Bijou will go to build and sustain a center for orphan street kids. When you buy Mon Bijou, you also buy into this idea. Mon Bijou™ is a line of fashion jewelry inspired mostly by nature and diverse cultures. Mon Bijou™ is USA hand made. We were able to find the exact same quality of Pewter that they have in France. Our jewelry is nickel & lead free, there is no problem with allergies. The jewelry base is pewter. It is Silver or Brass plated then varnished. You do not have to clean our Jewelry, but if you want to do so just use a 100% cotton cloth. We only use the best quality materials and Swarovsky crystal.


text:
Some Brits Don't Think An Alternate History Where the UK is Controlled by Nazis Sounds All That Bad
By Hannah Sole | TV | March 7, 2017 |
Apparently, some of my fellow Brits think we might have been better off if we had lost World War 2.
YOUR COMMENTS: Mail readers wistfully long for a UK controlled by Nazis because it would mean less immigrants. https://t.co/IbPSlxOr3l
— The DM Reporter (@DMReporter) March 2, 2017
Here's a slightly more readable version of the Tweeted link:
Here's the responses:
Disclaimer: these are comments from the Mail Online, so a certain amount of ridiculously hateful rubbish is to be expected.
But seriously, what sort of world do they think we are living in?
The original article was a feature in response to the BBC's new series SS-GB, based on the 1978 novel by Len Deighton, which imagines an alternative history where the real-life Nazi plan to conquer the UK, Operation Sea Lion, actually worked, and led to Britain's surrender and occupation.
Thanks to Operation Sea Lion, we know exactly what that would have meant for the UK: death squads, the end of the free press, the slaughter of British Jews, and oh yeah, this (via Wikipedia)
According to captured German documents, the commander-in-chief of the German Army, Walther von Brauchitsch, directed that "The able-bodied male population between the ages of 17 and 45 will, unless the local situation calls for an exceptional ruling, be interned and dispatched to the Continent". This represented about 25% of male citizens. The UK was then to be plundered for anything of financial, military, industrial or cultural value,[135] and the remaining population terrorised. Civilian hostages would be taken, and the death penalty immediately imposed for even the most trivial acts of resistance.
The deported male population would have most likely been used as industrial slave labour in areas of the Reich such as the factories and mines of the Ruhr and Upper Silesia. Although they might have been treated less brutally than slaves from the East (whom the Nazis regarded as sub-humans, fit only to be worked to death), living and working conditions would still have been severe.
In late February 1943, Otto Bräutigam of the Reich Ministry for the Occupied Eastern Territories claimed he had the opportunity to read a personal report by General Eduard Wagner about a discussion with Heinrich Himmler, in which Himmler had expressed the intention for special forces of the SS to kill about 80% of the populations of France and England after the German victory.[138] In an unrelated event, Hitler had on one occasion called the English lower classes "racially inferior".[139]
But hey, don't let that stop a bunch of cretins from wistfully imagining a white utopia where the trains run on time, and it's OK to execute people who disagree with you. Or thinking that a) we have Sharia Law here (we don't) and that b) at least Hitler would have saved us all from it. Oh, and ISIS as well. I know times are tough for a lot of folks, but let me put this in a language that they might understand:
HITLER WAS REALLY BAD.
THINK THINGS ARE BAD NOW?
HE'S WORSE THAN THAT.
Some of these commenters even seem to think that Hitler's grand plan to rule Europe worked in the end - in the form of the EU. That's right, an organization designed to make sure that That Sort of Thing never happened again, has been pulling the wool over our eyes for decades. There are not enough facepalms in the world.
These are some of the people cheering for Brexit — and as the government is preparing to invoke Article 50, I look at comments like this and howl. Dear Europe, please don't leave me alone on an island with these people!
And Dear Rest of the World, please don't judge us all on this. I guess we all have our baskets of deplorables…
PS: DM Reporter, it's 'fewer immigrants', not 'less'.
What We Can Learn From a Day Without a Woman
Paul Ryan Is Gonna Get His Ass Handed To Him Over the Obamacare Replacement Bill
Dustin is the founder and co-owner of Pajiba. You may email him here, follow him on Twitter, or listen to his weekly TV podcast, Podjiba.

redpajama_set_name: RedPajamaCommonCrawl


It's the last international break of the season, and thus, Tottenham Hotspur are currently off until March 31, when they visit Liverpool. We don't have a game to talk about for awhile, but there are plenty of transfer rumors to discuss. The summer transfer window doesn't open for awhile yet, but the futures of many key Spurs players remains up in the air.
Let's take a spin through the inter webs and see what's buzzing in Spurs cyberspace right now in regards to summer transfer rumors.
Tottenham Hotspur are ready to revamp the right back position, as they are keen on shipping out Kieran Trippier and Serge Aurier, claims The Sun.
Trippier, who had a solid World Cup with England this past summer, has been limited by injury and had a very disappointing club campaign.
The London outlet says Everton are interested, with a valuation to the tune of about £20 million. As for Aurier, Tottenham took a gamble and paid £23 million for a player who came with baggage from PSG, and it hasn't exactly paid off.
He just hasn't worked out, and Tottenham would, the narrative goes, be willing to part with him for even half of what they paid. If these deals actually get done, the north London side would absolutely half to go out get a replacement(s) and that would end their streak of transfer windows without a single acquisition streak at three.
The targets for Spurs include Aaron Wan-Bissaka of Crystal Palace and Max Aarons of Norwich City. Both of which would then, at least under this specific scenario, battle it out with Kyle Walker-Peters for the first choice slot at the position.
Shifting gears to another position group, midfielder Franck Kessie of AC Milan is a very sought after man, according to Calciomercato. You can count Spurs among the clubs, supposedly, interested in obtaining him, but it seems likely that a bidding war might ensue.
Given the pressing need that Tottenham's arch-rivals have at this position, expect them to pursue Kessie pretty aggressively.


text:
Paratinia sciarina är en tvåvingeart som beskrevs av Josef Mik 1874. Paratinia sciarina ingår i släktet Paratinia och familjen svampmyggor. Enligt den finländska rödlistan är arten nära hotad i Finland. Arten är reproducerande i Sverige. Artens livsmiljö är naturmoskogar. Inga underarter finns listade i Catalogue of Life.

Källor

Svampmyggor
sciarina

redpajama_set_name: RedPajamaWikipedia


text:
Carlo De Cesare (spr. tschessare) (* 1824 in Spinazzola, Apulien; † 1882) war ein italienischer Nationalökonom und Politiker.

Leben
De Cesare studierte die Rechte zu Neapel, trat zuerst als Dichter hervor mit den lyrischen Sammlungen: "Le ore di solitudine" und "Le armonie" sowie mit dem Roman "Il conte di Minervino" (1845). Ihnen folgten die Werke: "Dell' amministrazione della giustizia nel regno delle due Sicilie" (1849); "Delle opere penali di P. Ulloa" (2. Ausg. 1852) und "Intorno alla ricchezza pugliese" (1853). Beteiligt an den revolutionären Bestrebungen von 1849 bis 1853, wurde er eine Zeit lang eingekerkert. Nach der Befreiung Italiens wurde ihm 1860 das Generalsekretariat der Finanzen zu Neapel, 1868 das des Ackerbaues, der Industrie und des Handels übertragen; auch wurde er zu wiederholten Malen ins Parlament gewählt. Später wurde er Senator des Königreichs und Rat am obersten Rechnungshof.

Werk
Von seinen übrigen zahlreichen Schriften, welche den tüchtigen Gelehrten und Denker verraten, haben ein allgemeines Interesse: "Il mondo civile ed industriale nel XIX. secolo" (1857); "Della scienza statistica" (1857); "Dell' educazione alle arti e mestieri" (1859); "Del potere temporale del Papa" (2. Aufl. 1861); "Il passato, il presente e l'avvenire della pubblica amministrazione nel regno d'Italia" (1865); "La Germania moderna" (2. Aufl. 1874); "Le due scuole economiche" (2. Aufl. 1875); "Le nuove storie" (1876) und eine Biographie Scialojas (1879).

Ökonom (19. Jahrhundert)
Mitglied der Abgeordnetenkammer (Königreich Italien)
Person (Risorgimento)
Italiener
Geboren 1824
Gestorben 1882
Mann


A orphan parent with no sources shows reference ID LOOP if operating at stratum 1 and 127.0.0.1 (IPv4 loopback address) otherwise. While ordinary NTP clients use a selection metric based on delay and dispersion, orphan children use a metric computed from the IP address of each core server. Each orphan child chooses the orphan parent as the core server with the smallest metric.


Giraffe Healthcare CIC is a community interest company registered under the Companies Acts (company number SC595189) and has its registered office at c/o Glasgow Caledonian University, Cowcaddens Road, Glasgow, G4 0AB ("we", "our").
For the purpose of the General Data Protection Regulation ("GDPR"), we are the Data Controller of any personal data we collect from you via this website, http://www.giraffehealth.com ("website") or otherwise (including by telephone, email, post or face to face).
We respect your privacy and are committed to protecting your personal data. We adhere to the principles of the GDPR when processing your personal data.
This privacy notice (together with our terms and conditions and any other documents referred to within it) outlines how we collect and process your personal data through your interaction with the website or that you provide to us and how the law protects you. Please read this privacy notice so that you are aware of how and why we are using your personal data.
If you have: (i) any concerns about our processing of your personal data; or (ii), you have a general enquiry in relation to data protection, please contact lorna@giraffehealth.com.
You have the right to make a complaint at any time to the Information Commissioner's Office ("ICO"), the UK's supervisory authority for data protection issues (www.ico.gov.uk). We would, however, appreciate the chance to deal with your concerns before you approach the ICO so please contact us in the first instance.
Personal Data: means any information relating to an identified or identifiable natural person ("Data Subject") from which that Data Subject can be identified directly or indirectly (in particular, by reference to an identifier such as a name, an identification number, location data, an online identifier or to one or more factors specific to the physical, physiological, genetic, mental, economic, cultural or social identity of that natural person).
When we refer to "personal data", we mean both personal and special category of data.
We primarily collect personal data from you through your direct interactions with us by email, telephone or face to face.
Any other information you post, e-mail or otherwise send to us.
4. Where will we store your data?
Your personal data will be stored in the UK.
Where we need to collect personal data by law, or under the terms of a contract we have with you, and you fail to provide that data when requested, we may not be able to perform the contract we have or are trying to enter into with you. In this case, we may have to cancel a product or service you have with us but we will notify you if this is the case at the time.
To provide our services to you, we need to know your name, contact details and medical diagnosis.
For office administration and internal record keeping purposes.
We have set out below a description of the ways we plan to use your personal data, and which of the legal bases we rely on to do so. We have also identified what our legitimate interests are (where appropriate).
To register you as a new client.
To process and deliver our web based physio services.
(c) Necessary for our legitimate interests (to keep our records updated and to study how clients use our web based physio services).
To respond to an enquiry made through the website Email address. It is in our legitimate interest to provide you with information regarding our services, and to provide an efficient service to you as a potential or existing client.
Cookies through the website Technical data regarding your equipment, browsing actions and patterns. We ask you to provide consent for all non-essential cookies that we use on the website.
Where you opt out of receiving these marketing messages, this will not apply to personal data provided to us as a result of a service purchase or other transaction.
to protect the rights, property, or safety of us or others. This includes exchanging information with other companies and organisations for the purposes of fraud protection and credit risk reduction.
In all instances where we disclose your personal data to third parties, we will ensure that your data is appropriately protected.
Where our suppliers process our personal data on our behalf, we require them to put in place appropriate security measures to protect your personal data in line with our policies. We do not allow our suppliers to use your personal data for their own purposes and only permit them to process your personal data for specified purposes, in accordance with our instructions and data protection law.
We do not transfer your personal data outside the European Economic Area (the "EEA").
11. Is your personal data safe?
We work hard to protect your personal data and have adopted appropriate technical and organisational measures to prevent it from being accidentally lost, used or accessed in an unauthorised way, altered or destroyed.
Unfortunately, the transmission of information via the internet is not completely secure. Although we will do our best to protect your personal data, we cannot guarantee the security of your personal data transmitted to us via the internet. Any transmission is at your own risk.
We will only retain your personal data for as long as reasonably necessary to fulfil the purposes we collected it for (including, for the purposes of satisfying any legal, regulatory or reporting requirements). We may retain your personal data for a longer period in the event of a complaint or if we reasonably believe there is a prospect of litigation in respect to our relationship with you.
Cookies are small text files that are stored on your computer or mobile device when you visit the website.
You have the right to ask us to erase the personal data we hold about you. Such circumstances include: (a) where we no longer need your personal data for the purposes set out above; (b) if you withdraw your consent to our processing; (c) if you object to our processing based on our legitimate interest and we have no overriding legitimate grounds to continue processing your personal data; (d) if we process the data unlawfully; or (e) where the personal data has to be erased to comply with legal obligation to which we are subject. We will consider any such request in line with data protection law. Please note this is not an absolute right and there may be circumstances where we choose not to delete all of the personal data we hold about you. More information about your right of erasure can be found at www.ico.org.uk.
If you would like to exercise any of the rights set out above, please contact lorna@giraffehealth.com.
We keep this privacy notice under regular review. Any changes we may make to our privacy notice in the future will be posted on the website and, where appropriate, notified to you by e-mail. Please check back frequently to see any updates or changes to our privacy notice.
Questions, comments and requests regarding this privacy notice are welcomed and should be addressed to lorna@giraffehealth.com.


text:
A VLP for validation of the Plasmodium falciparum circumsporozoite protein junctional epitope for vaccine development.
Atcheson E., Hill AVS., Reyes-Sandoval A.
Malaria continues to be a pressing global health issue, causing nearly half a million deaths per year. An effective malaria vaccine could radically improve our ability to control and eliminate this pathogen. The most advanced malaria vaccine, RTS,S, confers only 30% protective efficacy under field conditions, and hence the search continues for improved vaccines. New antigens and formulations are always first developed at a pre-clinical level. This paper describes the development of a platform to supplement existing tools of pre-clinical malaria vaccine development, by displaying linear peptides on a virus-like particle (VLP). Peptides from PfCSP, particularly from outside the normal target of neutralizing antibodies, the central NANP repeat region, are screened for evidence of protective efficacy. One peptide, recently identified as a target of potent neutralizing antibodies and lying at the junction between the N-terminal domain and the central repeat region of PfCSP, is found to confer protective efficacy against malaria sporozoite challenge in mice when presented on the Qβ VLP. The platform is also used to explore the effects of increasing numbers of NANP unit repeats, and including a universal CD4+ T-cell epitope from tetanus toxin, on immunogenicity and protective efficacy. The VLP-peptide platform is shown to be of use in screening malaria peptides for protective efficacy and answering basic vaccinology questions in a pre-clinical setting.
NPJ vaccines
The Jenner Institute, University of Oxford, Oxford, UK.


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