text:
Polskie Dokumenty Dyplomatyczne (PDD) – seria ukazująca się od 2005 roku w której są publikowane dokumenty źródłowe dotyczące historii polskiej polityki zagranicznej w latach 1918–1989. Wydawcą jest Polski Instytut Spraw Międzynarodowych. Redaktorem serii jest Włodzimierz Borodziej.

W ramach serii publikowane są dokumenty z okresu II Rzeczypospolitej i Polskiej Rzeczypospolitej Ludowej. Dokumenty władze RP na emigracji są publikowane jedynie do 5 lipca 1945 roku. Publikowane są źródła wytworzone przez Ministerstwo Spraw Zagranicznych i najważniejsze dokumenty, które powstały w Radzie Ministrów, akta partyjne (KC PZPR), korespondencja z ministerstwami itd. Każdy z tomów z reguły obejmuje jeden rok kalendarzowy. Tom składa się ze wstępu, edycji dokumentów oraz indeksu osobowego i rzeczowego.

Redakcja:
 Redaktor naczelny:  Włodzimierz Borodziej
 Członkowie: Jerzy Wojciech Borejsza, Bogdan Grzeloński, Sławomir Dębski, Małgorzata Gmurczyk-Wrońska, Magdalena Hułas, Marek Kornat, Maciej Koźmiński, Andrzej Kunert, Paweł Machcewicz, Piotr M. Majewski, Andrzej Paczkowski, Adam Daniel Rotfeld, Krzysztof Ruchniewicz, Małgorzata Ruchniewicz, Ryszard Stemplowski, Jacek Tebinka, Mariusz Wołos, Stanisław Żerko

Wydane tomy
Do 2022 r. ukazały się:
 Polskie dokumenty dyplomatyczne 1972, red. Włodzimierz Borodziej, współpr. Piotr Długołęcki, 2005.
 Polskie dokumenty dyplomatyczne 1939 styczeń – sierpień, red. Stanisław Żerko, współpr. Piotr Długołęcki, 2005.
 Polskie dokumenty dyplomatyczne 1957, red. Krzysztof Ruchniewicz, Tadeusz Szumowski, współpr. Piotr Długołęcki, 2006.
 Polskie dokumenty dyplomatyczne 1973, red. Piotr M. Majewski, wstęp Piotr M. Majewski, 2006.
 Polskie dokumenty dyplomatyczne 1938, red. Marek Kornat, współpr. Piotr Długołęcki, Maria Konopka-Wichrowska, Marta Przyłuska, 2007.
 Polskie dokumenty dyplomatyczne 1939 wrzesień – grudzień, red. Wojciech Rojek, współpr. Piotr Długołęcki, Maria Konopka-Wichrowska, Marta Przyłuska, 2007.
 Polskie dokumenty dyplomatyczne 1974, red. Aleksander Kochański, Mikołaj Morzycki-Markowski, 2007.
 Polskie dokumenty dyplomatyczne 1918: listopad-grudzień, red. Sławomir Dębski, współpr. Piotr Długołęcki, 2008.
 Polskie dokumenty dyplomatyczne 1931, red. Mariusz Wołos, 2008.
 Polskie dokumenty dyplomatyczne 1976, red. Piotr Długołęcki, 2008.
 Polskie dokumenty dyplomatyczne 1977, red. Piotr M. Majewski, współpr. Piotr Długołęcki, 2009.
 Polskie dokumenty dyplomatyczne 1940, red. Magdalena Hułas, 2010.
 Polskie dokumenty dyplomatyczne 1975, red. Paweł Machcewicz; współpr. Piotr Długołęcki, 2010.
 Polskie dokumenty dyplomatyczne 1958, red. Dariusz Jarosz, Maria Pasztor, 2011.
 Polskie dokumenty dyplomatyczne 1932, red. Krzysztof Kania, 2011.
 Polskie dokumenty dyplomatyczne 1936, red. Stanisław Żerko, współpr. Piotr Długołęcki, 2011.
 Polskie dokumenty dyplomatyczne 1959, red. Piotr Długołęcki, 2011.
 Polskie dokumenty dyplomatyczne 1937, red. Jan Stanisław Ciechanowski, współpr. Piotr Długołęcki, 2012.
 Polskie dokumenty dyplomatyczne 1941, red. Jacek Tebinka, 2013.
 Polskie dokumenty dyplomatyczne 1934, red. Stanisław Żerko, współpr. Piotr Długołęcki, 2014.
 Polskie dokumenty dyplomatyczne 1979, red. Piotr Długołęcki, Jerzy Kochanowski, 2014.
 Polskie dokumenty dyplomatyczne 1933, red. Wojciech Skóra, współpr. Piotr Długołęcki, 2015.
 Polskie dokumenty dyplomatyczne 1919 styczeń-maj, redaktor Sławomir Dębski, 2016.
 Polskie dokumenty dyplomatyczne 1935, red. Stanisław Żerko, współpr. Piotr Długołęcki, 2017.
 Polskie dokumenty dyplomatyczne 1980 styczeń-czerwiec, Piotr Długołęcki, 2018.
 Polskie dokumenty dyplomatyczne 1919 czerwiec-grudzień, redaktor Sławomir Dębski, 2019.
 Polskie dokumenty dyplomatyczne 1980 lipiec-grudzień, Piotr Długołęcki, 2020.
 Polskie dokumenty dyplomatyczne 1981 styczeń-czerwiec, Piotr Długołęcki, 2021.
 Polskie dokumenty dyplomatyczne 1981 lipiec-grudzień, Piotr Długołęcki, 2022.

Przypisy

Bibliografia
 Henryk Bartoszewicz, Niemcy, Wolne Miasto Gdańsk i Związek Sowiecki w świetle polskich dokumentów dyplomatycznych z 1932 r., "Dzieje Najnowsze" 44 (2012), nr 2, s. 165–180 [recenzja: Polskie dokumenty dyplomatyczne 1932].
 Henryk Bartoszewicz, Polskie dokumenty dyplomatyczne 1938 – recenzja, "Dzieje Najnowsze" 40 (2008), nr 4, s. 236–241.
 Włodzimierz Borodziej, Piotr Długołęcki, Polskie Dokumenty Dyplomatyczne: bilans dziesięciolecia, czyli po pierwszych 20 tomach, "Sprawy Międzynarodowe" 67 (2014), nr 4 s. 171–181.
 Polskie dokumenty dyplomatyczne prospekt, Warszawa: Polski Instytut Spraw Międzynarodowych 2009..
 Anna Cienciała, Polskie dokumenty dyplomatyczne – recenzja, "Kwartalnik Historyczny" 117 (2010), nr 1, s. 81–90 [recenzja: Polskie dokumenty dyplomatyczne: 1939 wrzesień – grudzień].
 Wanda Jarząbek, Niewykorzystana szansa?, "Dzieje Najnowsze" 44 (2012), nr 3, s. 140–153 [recenzja: Polskie Dokumenty Dyplomatyczne, Warszawa 2005-2011].

Linki zewnętrzne

Wydawnictwa źródłowe
Serie wydawnicze z zakresu historii
Polityka zagraniczna Polski
Polski Instytut Spraw Międzynarodowych


text:
Q: Load Text Files and store it in Dataframe using Pyspark I am migrating pig script to pyspark and I am new to Pyspark so I am stuck at data loading.
My pig script looks like:
Bag1 = LOAD '/refined/em/em_results/202112/' USING PigStorage('\u1') AS
(PAYER_SHORT: chararray
,SUPER_PAYER_SHORT: chararray
,PAID: double
,AMOUNT: double
);
I want something similar to this in Pyspark.
Currently I have tried this in Pyspark:
df = spark.read.format("csv").load("/refined/em/em_results/202112/*")
I am able to read the text file with this but values are coming in single column instead of separated in different columns. Please find below some sample values:
|_c0
|AZZCMMETAL2021/1211FGPP7491764     |
|AZZCMMETAL2021/1221HEMP7760484     |
Output should look like this:
_c0   _c1   _c2     _c3_c4 _c5 _c6 _c7
AZZCM METAL 2021/12 11 FGP P 7 491764
AZZCM METAL 2021/12 11 HEM P 7 760484
Any clue how to achieve this? Thanks!!

A: Generaly spark would try to take (,)[comma] as a separator value in you case you have to provide space as your separator.
df = spark.read.csv(file_path, sep =' ')

A: This resolves the issue. Instead of "\\u1", I used "\u0001". Please find below the answer.
df = spark.read.option("sep","\u0001").csv("/refined/em/em_results/202112/*")

redpajama_set_name: RedPajamaStackExchange


text:
// Auto-Generated by FAKE; do not edit
// <auto-generated/>
using System.Reflection;

[assembly: AssemblyTitle("Okanshi.SplunkObserver")]
[assembly: AssemblyProduct("Okanshi")]
[assembly: AssemblyDescription("In-process monitoring library")]
[assembly: AssemblyVersion("7.0.0")]
[assembly: AssemblyFileVersion("7.0.0")]
[assembly: AssemblyConfiguration("Release")]
namespace System {
    internal static class AssemblyVersionInformation {
        internal const System.String AssemblyTitle = "Okanshi.SplunkObserver";
        internal const System.String AssemblyProduct = "Okanshi";
        internal const System.String AssemblyDescription = "In-process monitoring library";
        internal const System.String AssemblyVersion = "7.0.0";
        internal const System.String AssemblyFileVersion = "7.0.0";
        internal const System.String AssemblyConfiguration = "Release";
    }
}

redpajama_set_name: RedPajamaGithub


text:
Malta Info Guide
More Then Just An Island
Malta, Gozo & Comino
Gozo Island
Comino Island
Valletta Malta
Christmas In Malta
Tours In Malta
Events On The Island
Village Feasts
Malta UNESCO Sites
Beaches In Malta & Gozo
Coming To Malta?
Getting To And Around Malta
Photos Of Malta
top 6 Megalithic Temples Of Malta
discover the six sites that take you back in time
The Megalithic temples of Malta are the evidence to the origins of the first inhabitants of the Maltese Archipelago.
Before you embark on your holiday to Malta, there are a few things you can learn about what happened many centuries ago.
We will help you prepare for your holiday, satisfy your curiosity and make your trip unforgettable.
Seven megalithic temples are located on the islands of Malta and Gozo, each with its own individual refinement. All of these temples have been acknowledged by the UNESCO World Heritage Site as being unique architectural masterpieces given the limited resources available to their builders.
the top 6 megalithic temples of malta
Hagar Qim Temples
Mnajdra Temples
Tarxien Temples
Skorba Temples
Ta' Hagrat Temples
1. Hagar Qim Temples
Date 3600 – 3200 BC
Did you ever here about the equinoxes and solstices? The builders of Hagar Qim temples were so intelligent as being able to align the temples with the first rays of the rising sun.
The south temple is astronomically aligned. You can experience this phenomena on site but you have to be in Malta on specific dates as it only happen four times a year, at least you can visit any day during the year and just be there to think what incredible buildings and astronomers these people were. At the visitors centre you can get an insight through a model of how it takes place.
They are today protected by a permanent tent which also protects you from the sun or rain while visiting. The builders were surely intelligent enough to choose such an unparalleled location on top of a cliff with great views of the open sea and just in front a small island called Filfla.
facts about hagar qim temples
They are very well preserved ruins.
These temples were built from soft globigerina limestone.
The World Heritage Sites committee described the sites as an incredible architectural gem.
Indications that the temples were covered.
The name of Hagar Qim means standing/worshipping stones.
Unrivalled location at the top of a cliff facing the sea with the island of Filfla in front.
A protective tent was installed during 2009 to protect them from the elements.
2. Mnajdra Temples
Visiting Mnajdra temples and further down the Hagar Qim temples is a perfect place for a walk in the countryside overlooking the sea. Located on top of a high cliff with a sharp fall down to sea level and a view of Filfla island. How intelligent these people where to choose these locations.
Built around the fourth millennium BC, they are among the oldest on the earth. It consists of three religious temple sites, combined but not connected: the upper, middle, and lower. Built from coralline limestone which is a much harder stone to cut and form than the globigerina limestone used for its neighbouring temple.
It lies very close to the famous Blue grotto caves.
facts about mnajdra temples
The World Heritage Sites committee characterised the sites as exceptional architectural treasures.
A protective tent was installed during 2009.
These temples were built form coraline limestone but Hagar Qim was built by a softer stone called soft globigerina limestone.
3. Tarxien Temples
If you love activity and adventure Tarxien temples is surely one of them. Several megalithic temples can be visited in Malta. It is the largest of all the temples with four defined temples all beside each other.
Here you find the unique and famous "fat lady" statue representing a mother goddess, only the lower half was found during excavations and the original and various unique sculptures are indoors at the Malta Archaeological Museum at Valletta. These decorative features are very unique and it is an opportunity to visit them on locations to appreciate a showcase of prehistoric art within the context of the temples.
Found in 1913 by farmers while plowing their fields, these findings further consolidated the survival of a prosperous ancient community which lived on the islands.
other facts about malta tarxien temples
In 2015 a tent covering the whole site was erected in order to protect the temples from the elements.
4. Ggantija Temples
Walk a while backwards when the Ggantija temples were built, not a few years but much more than you think. These are the earliest you can find on the islands built during the fourth millennium BC, they are older than the pyramids of Egypt. This is an incredible location surely not to be missed. At the south corner of the temple you can still find it standing at 7 metres high after so many years.
All this you can see if you visit. It is not a mass of stones but so much to learn and you can get so much insight by visiting the visitors centre.
The name Ggantija comes from the Maltese word that translates to giants. This is what the local people used and still call it. This is all due to the massive stones that are found here weighing up to 20 Tonnes. The plan is vaguely comparable to the outline of an obese human form.
facts about ggantija temples
Older than the Stonehenge England and Pyramids of Egypt by a thousand (1,000) years.
Included as one of UNESCO World Heritage List.
5. Skorba Temples
Date: 4500 – 4100 BC
The Skorba temples located around one kilometre outside the village of Mgarr. It is difficult to think how important these sites were for the people who lived here so long ago and who themselves built them with such an accuracy and so much sacrifice. Today they are much in ruin after all these thousands of years. If we just think how much we care for our homes much the same these people were for their temples.
Today they are not in a good condition compared to the others on the island but several findings shed interesting information about Malta's Neolithic culture.
6. Ta' Hagrat Temples
The Ta´ Hagrat temple complex is located in a very quiet area on the islands, around the village of Mgarr where you find farmers tilting their fields. A triple visit to see these temples and the others close by the Skorba temples and the small village.
It consists of two Megalitic temples. The smaller one touches the bigger one on the north side.
It is known that the temples were constructed on an older site which dates from 4,100 - 3,800 BCE.
The site was excavated in 1923 by Sir Temi Zammit and once more between 1925 and 1927 with the direction of G.G. Sinclair. During 1937 all the site was rehabilitated.
facts about Ta' Hagret temples
Many deposits of pottery were found which shows that there was a village on this site which is dated to 3800 – 3600 BC.
The most interesting find was a small model of a temple
It is one of the smaller temple complexes on the islands.
map of all 6 megalithic temples of malta
All the following sites are protected under Heritage Malta.
Megalithic Temples Of Malta
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redpajama_set_name: RedPajamaCommonCrawl


It shows all those properties except rowSelector. Does this mean the API docs are missing this property or the test is using a property that no longer exists / never existed? I'm pretty sure the API is just missing this property.


BOSTON, MA –  Citizen Schools strongly supports the recommendations released today by the Aspen Institute National Commission on Social, Emotional, and Academic Development. "From a Nation at Risk to a Nation at Hope" asserts that our nation is at a turning point: We now understand that social, emotional, and cognitive development underpin children's academic learning. This breakthrough understanding about how people learn is fueling a growing movement to educate children as whole people, with social and emotional as well as academic needs.
"A Nation at Hope" emphasizes that translating knowledge about how people learn into practice and helping students develop skills like collaboration, empathy, and perseverance requires systemic change. It offers specific actions in research, practice, and policy to fundamentally shift how we teach children, with the understanding that the social, emotional, and cognitive dimensions of learning are mutually reinforcing rather than distinct.
Citizen Schools, which is a members of the Commission's Partner Coalition, is committed to advancing social, emotional, and academic development. Citizen Schools' evidence-based model provides middle school students in urban communities with exposure to mentors and real world project-based learning that supports skill building in self-management, goal setting and future planning, and specific academic and career skills and knowledge. Citizen Schools is launching a new national initiative, Catalyst, to match middle school science and technology teachers with industry experts in the delivery of project-based learning experiences to promote whole child development.
What sets "A Nation at Hope" apart from other reports is the groundswell of support that has surged over the course of the Commission's work and that now supports action across communities following its release. Citizen Schools is one of nearly 100 organizations that have signed on in support of the report's conclusions and recommendations as part of an ever-widening coalition committed to advancing the work.
Drawing on input from more than 200 scientists, youth and parent groups, educators and policymakers, the report seeks to accelerate and strengthen efforts in local communities. These recommendations are especially pertinent as states and communities continue to leverage their increased authority on education policy under the federal Every Student Succeeds Act. The report includes specific strategies that schools, districts, and communities can pursue related to each recommendation and examples of places that are engaged in these efforts.
The report also outlines evidence that confirms that supporting students' social, emotional and academic development has a positive impact on their attendance, test scores, success in college and careers, and overall well-being. This approach also improves students' feelings about school and makes schools safer.
More information, including a toolkit to communicate about social, emotional, and academic development, is available at NationatHope.org.


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Experiment with ideas. Test and see which works better. Analyze your data.
These are phrases we often use on this blog. To us, social media marketing is a bit of a science. We recommend testing things, running experiments, and analyzing data — because it worked for us. This experimental mindset has helped us grow our social media results.
But one thing we haven't done well is to explain the how: how to run social media experiments.
In this post, you'll learn the six simple steps of running social media experiments. We've even included 87 ideas, which you can start testing immediately.
Running social media experiments can be hard when you're not sure where to start and where to head to. Here's a step-by-step guide to help you hit the ground running.
Before we dive into the guide, here's a quick caveat: social media experiments are not perfect or entirely scientific. Some factors are out of our control, such as organic reach since it's determined by the social media algorithms.
This doesn't mean we wouldn't get meaningful results (it has worked for us and many others); it's just good to be mindful of this while running your experiments.
As with most planning, it's crucial to start by setting your goals. Why?
Imagine the following situation. Both social media posts are sharing the same blog post with a different headline.
Post A received 100 Likes, 100 shares, 10 clicks, and 5,000 impressions.
Post B received 10 Likes, 10 shares, 100 clicks, and 1,000 impressions.
Which post do you think is better?
I think it depends on your goals! If you think social media is for engagement, you'll likely prefer Post A. But if you think social media is for driving traffic, you'll probably prefer Post B instead.
For us, our overarching goal for social media is engagement and brand-building. (Here's why.) So we focus more on our social media reach, engagement, and following than traffic, leads, or revenue from social media.
Having said that, each social media post can sometimes have its own micro-goal. For example, while our overall social media goal is engagement and majority of our posts are meant for generating engagement, we have some posts that are meant for driving traffic, such as this and this.
because they are content proven to be popular.
This is my favorite method because there's so much written about social media marketing every day. Listicles and case studies of successful social media tactics can be a great source of inspiration for experiment ideas.
There's also a huge list of 100 social media experiment ideas below. Click here to skip right to it, and feel free to take any of the ideas.
The second method is to follow social media trends.
For example, videos are becoming the most popular content format on social media. Facebook has been pushing for videos on its platform for the last few years, and LinkedIn has recently introduced native videos. Our internal data also showed that videos received an average of 873 interactions per post, compared with 279 for photos and 190 for text posts.
So it'll be a good idea to test videos on your social media profiles.
We recently wrote about the 10 major social media trends for 2018, which you might find useful for generating ideas.
What ideas can you think of in light of these trends?
The final method is to watch and learn from the best companies in your industry and your competitors. What have they been doing that is worth trying yourself?
It's also good to be aware that the ideas that worked for them might not always work for you. You all likely have many differences such as branding, positioning, and audience. But if you think an idea is suitable for your brand, I would say go for it and modify it for your own brand.
There are some free tools you can use to track industry leaders and competitors.
On Facebook, you have Pages to Watch. It allows you to quickly check out the recent top posts of similar Facebook Pages. You can find it at the bottom of the Overview tab in your Page Insights.
On Twitter, you could add your favorite companies to a Twitter list. To create a Twitter list, click on your profile photo in the upper-right corner and click on "Lists". Then, click on "Create new list" and fill out the information.
On LinkedIn, you have the Companies to track feature in your Company Page analytics. Clicking on any of the company names will bring you to their Company Page. You can access this section by clicking on Analytics > Followers.
The next step is to prioritize your ideas. A prioritization framework we like to use at Buffer is the ICE score by GrowthHackers.
ICE stands for Impact, Confidence, and Ease.
For each experiment, give each factor a score from one to 10. The overall score is determined by taking the average of the three scores. You should start with the experiment that has the highest score.
Curating top third-party content will increase our reach on Facebook.
Partnering with micro-influencers will grow our Instagram reach.
Based on the ICE score, I would run experiment A before experiment B.
While this process can be a little time-consuming at the start, it's important. It'll help you think through the experiment details (such as what metric to track) and maximize your impact with the resources you have.
After a while, you should be able to build up a good intuition about the potential of ideas without having to score every single idea.
Now you're ready to test your top ideas!
There are a few things you want to be mindful when testing.
(Ideally) test one thing at a time to understand what's making the difference. For example, if you want to test your copy as an experiment, it'll be best to keep the multimedia the same. Otherwise, you won't know if the copy or the multimedia caused one post to outperform the other.
Look at the right metrics to measure the results of your experiment. This is where the goals you've set will be helpful. For instance, if you want to maximize your social media reach, you would pick reach or impressions over clicks.
Run each experiment for at least a week for smaller experiments. This isn't entirely scientific but I believe a week is sufficient for the results to be seen. For bigger experiments such as shifting your social strategy to posting more videos, you might want to test it for a month to a quarter. The bigger the experiment, the longer it should be tested.
Did it achieve the results I had expected? Why?
Did any other factors contribute to the success or failure?
Can I learn anything else from this experiment?
To help you with your experiment tracking, I've created a simple tracking template: Social Media Experiment Tracking. Feel free to make a copy and modify it to your liking.
When running scientific experiments, it's important to look at the statistical significance of the results — to ensure that the result isn't a fluke and can be repeated successfully. But for social media experiments, it might not always be feasible. That's because your sample size (impressions of a post) isn't within your control.
My non-scientific recommendation here is to repeat the experiment a few times and see if the result remains the same. If the result can be repeated, you can consider turning the experiment into a regular part of your social media marketing.
Congratulations! You have just planned, run, and analyze a social media experiment!
Whether you had a successful experiment or not, it'll be great to repeat step four (test) and five (analyze and learn) continuously. Then once a quarter, you could take a step back and look at the bigger picture again. Your social media goals might have changed, or there might be new social media tactics to try.
Re-evaluate your goals, brainstorm new ideas, and test them. All the best!
How do you run social media experiments?
I'm curious about how you run your social media experiments. Do you use a framework or system? Do you use any tools to help you with it? Let's chat in the comments section below.
The amazing featured image is by chuttersnap, taken from Unsplash.


text:
Proceedings: DIA China 2020
Driving Co-Development of Therapeutic Drugs and Companion Diagnostics
Increased Regulatory Focus on Precision Medicine in China
Jennifer Sheng
Ningxia Western Cloud Data Technology Co. Ltd.
apid development of personalized (also known as precision) medicine has made separating patients into different groups and customizing treatments or products based on their genomic information an important trend.
Development of companion diagnostics (CDx) as powerful tools in precision medicine typically follows one of three pathways: co-development, bridging, and follow-on. Co-development is the most ideal and cost-effective CDx pathway: It is conducive to screening target patients specifically and identifying drug targets accurately, reducing development cost and cycle times for pharmaceutical companies. The DIA China 2020 session Driving Co-Development of Therapeutic Drugs and Companion Diagnostics for Precision Medicine and Optimizing the Clinical Trial Design reviewed the regulatory framework for drug and diagnostic co-development and how to overcome the inevitable hurdles to quickly delivering innovative drugs and diagnostics to patients.
The US, EU, and China each have their own CDx regulatory policies. The US entered the global CDx market earlier than the other two, and also has the most established CDx regulatory documentation and history. Regulatory policy in the US is established by the FDA. Regulatory policies for CDx in the EU are in a transition period.
Although CDx regulation in China is less advanced than in the US, the National Medical Products Administration (NMPA) has paid increasing attention to regulatory guidelines for CDx development and encourages co-development based on the Technical Review Guideline of Clinical Trial for Co-Development of CDx Reagents and Anti-Tumor Drugs, which China's Center for Medical Device Evaluation (CMDE) announced on June 3, 2020.
Drug and CDx co-developers need early planning and engagement to accelerate regulatory approvals and reduce costs.
Data available from FDA show that 25 percent (11 of 44) of therapeutic NME medicinal product approvals in 2019 are considered personalized medicines; NMEs as personalized medicines increased from 21 percent in 2014 to 42 percent in 2018. In Europe, approximately 30 percent of NMEs approved from January to August 2020 required a diagnostic test for patient identification. Pairing diagnostic tests that can determine an individual patient's responsiveness to therapeutic options can improve the drug development process. Drug and CDx efficacy are essential to the practice of precision medicine.
CDx are defined by the FDA as tests that are required for the safe and effective use of a drug. In 2014, FDA issued Guidance for Industry: In Vitro Companion Diagnostic Devices to inform diagnostic developers that CDx can be indicated for a group of therapeutic products, instead of one particular drug, if there is sufficient data to support such labeling. In 2016, FDA issued the draft guidance Principles for Co-Development of an In Vitro Companion Diagnostic Device with a Therapeutic Product as a practical guide to assist therapeutic product sponsors and in vitro diagnostic device (IVD) sponsors in developing a therapeutic product with an accompanying IVD companion diagnostic (a process referred to as co-development). In April 2020, FDA published a final guidance Developing and Labeling In vitro Companion Diagnostic Devices for a Specific Group of Oncology Therapeutic Products, which lists several key FDA considerations for CDx manufacturers considering a class-based label and clarifies the process required to apply for and be granted one.
CDx regulatory policies in the EU are in transition. Regulation 2017/746 on in vitro diagnostic medical devices (IVDR) entered into force in Europe and will be fully effective on May 26, 2022. This regulation establishes the first European regulatory link between the approval of drugs and CDx.
Despite the fast-growing market for CDx products, China has no published CDx-specific regulatory guidelines and no clear regulatory definition of CDx-related products. Most of these types of related products have been registered as Class III medical devices and approved based on current medical device and IVD regulations. China's CMDE (a division of NMPA) announced the preparation of the Technical Review Guideline of Clinical Trial for Co-Development of CDx Reagents and Anti-Tumor Drugs in June 2020. This encouraged co-development between discovery research laboratories and pharmaceutical companies. In July 2020, China's CMDE published the draft version of Guidelines for Package Insert Update and Technical Review of CDx for the Same Kind of Therapeutic Drug. In August 2020, CMDE issued the draft Guidance for Clinical Study of CDx for the Marketed Oncology Drugs. These national guidelines and regulations continue to create favorable conditions for development of drug–CDx reagents in China.
Co-developing drugs and diagnostics can accelerate their respective regulatory approvals while reducing costs. However, many pharmaceutical companies seem to ignore the registration of CDx. Because this CDx application and registration period will take approximately three years, the best practice is for drug and diagnostic developers to pair up early and develop a strategy that considers the policies of global regulatory bodies as well as each stage in the process, from development through testing, up to access and adoption.
Unlike drug products, CDx products have not fully entered the Chinese market; as a result, real world CDx studies, such as bridging studies and follow-on pathways, are often not suitable in these situations. However, real world studies may offer a new pathway for CDx development as more products enter the market in China.
Drug–diagnostic co-development integrates the biopharmaceutical and diagnostic landscapes and is at the forefront of ongoing work by discovery research laboratories, pharmaceutical companies, and regulatory bodies. Development and improvement of regulatory policies will present more options for drug–diagnostic co-development and bring a more promising future for pharmacotherapy and patient care in China.


Veteran Faces Charges After Being Shot at VA?
Negrete's service record, obtained by The AP from the U.S. Army Human Resources Command at Fort Knox, Kentucky, shows that Negrete served in Iraq for one year starting in October 2008 and then in Afghanistan from October 2010 to August 2011.
SALEM, Ore. — An Army veteran who was shot during a confrontation inside a Veterans Affairs clinic in Oregon where he went to seek help for mental problems was in jail Tuesday, charged with attempted assault, unlawful use of a weapon, menacing and other crimes.
Gilbert "Matt" Negrete allegedly displayed a knife Thursday after arriving at the clinic in White City, where he had an appointment. The Jackson County Sheriff's Office said VA police tried "less-lethal force options" to disarm Negrete before one of the officers fired, hitting him in the chest. Negrete, 34, was flown to a hospital in nearby Medford. No one else was injured.
Negrete was released from the hospital Saturday and is in the county jail with bail set at $250,000, Deputy District Attorney Laura Cromwell told The Associated Press. Negrete was arraigned Monday via a video hookup from jail, Cromwell said. He is being provided with a public defender.
Authorities will convene a grand jury later this week which will determine whether to indict Negrete, Cromwell said in a telephone interview. She anticipates that his attorney will urge the grand jury to take Negrete's military history into account. At least five of seven jurors must concur for the case to move forward.
Homelessness among veterans rises in D.C.
Veteran Affairs Secretary David J. Shulkin has expressed concern that homelessness among former troops in the District has inched higher, even as it has fallen nationwide.
According to the annual "Point-in-Time" tally of people sleeping outdoors in winter, the District counted 672 homeless in 2017, up from 350 in 2016. The data from last week's PIT tally will be available in May.
In addition, 14.1 percent of the District's 28,400 veterans were reported living in poverty in 2016, up from 10.5 percent in 2015, according to the Census Bureau.
Citing poverty as a leading risk factor for homelessness, federal and local providers of human services have begun shifting resources to address the needs of veterans at risk of becoming homeless.
He told the inquest in Woking, Surrey today that former sergeant Andrew Gavaghan jumped out of a makeshift coffin - which had originally been filled with sandbags - as soldiers carried it during a practice session ahead of the funeral.
A former Army sergeant hid inside and jumped out of a makeshift coffin which was being used by soldiers to practice for the funeral of a young recruit who had died in a shooting at the controversial Deepcut barracks, a coroner heard today.
Pte Sean Benton was found dead with five bullet wounds to his chest on June 9, 1995. The 20-year-old was the first of four recruits to die at the Surrey barracks in seven years, a new inquest into his death has heard.
Former fellow recruit and close friend Neil Williams was initially refused permission by officers to attend the funeral but was finally allowed when Pte Benton's mother, Linda, requested him was a pallbearer.
Mr Williams also told how he was asked to take part in the clear-up at the site of Pte Benton's shooting.
After reading that sheriff's deputies had shot and killed a disturbed young veteran who had threatened deputies with a shotgun, two local Vietnam veterans were moved to do something.
Bud Huffman and Jim Muhr left the service decades ago, but have had to cope with post-traumatic stress disorder ever since.
Now they hope to reach out to other local veterans struggling to avoid another such tragedy.
In June, Jacob Brown had a PTSD attack on his birthday near his home in Beaver Valley Estates. Frightened, Brown's wife fled the area with their children and went to Prescott to stay with family. Alone, Brown stormed around the two-story rental. Surveillance cameras, which Brown had installed inside and outside the home, picked up his movements.
On the phone, Brown told his uncle he wanted to kill himself, but couldn't reach the trigger on his shotgun. His uncle called 911 for help. The two deputies had moved onto the porch with guns drawn when Brown stormed out of his home. Brown ignored orders to put down his weapon, so the officers fired on him.
Both Muhr and Huffman recently met with GCSO supervisors, deputies and correctional officers in both Payson and Globe to offer their assistance as members of the Payson Veterans Advocacy Committee. Generally, officers have little training in how to deal with someone suffering from PTSD and the sheriff's office doesn't have a special unit to deal with things like a confrontation with a mentally ill person or even a hostage-taking situation.
God grant me peace with memories of yesterday.
Courage to face what comes knowing I can make a difference this day.
Hope that tomorrow will be a better day.
Yesterday is gone. I cannot change what has been.
Help me do the best I can today and tomorrow, begin again.
You created me to be able to help others.
Help me to accept help from others.
You created within me courage to do what had to be done.
Help me to ask for help when the one in need is this one.
You surrounded me with people who would die for me.
Help me trust them with my heart so they may see the wound within me.
do for others as you created me to do.
When I think about regular people, like me, losing hope to the point where they commit suicide, it is heartbreaking.
Hope is what keeps all of us from giving up this life we have. Often it is not enough to love others, if we feel as if we do not deserve to be loved.
There was a time in my life when I felt that way. While I did not attempt suicide, I prayed that God would to it for me. I lost hope, a sense of self worth, but above those, I lost faith that God even cared about me.
When the people committing suicide were those who dedicated their lives to saving others, it is beyond heartbreaking.
If you are among those in the military, veterans, police, firefighters and first responders, please read the prayer I wrote for you because after all these years of working with some of you, that is what I see within all of you!
INDIANAPOLIS — The Indiana National Guard says one of its soldiers has died after arriving for training at Fort Hood in Texas.
101st Soldier rescued people from burning car...including himself!
"As I was [unbuckling her seatbelt] the whole vehicle caught fire, and I just felt a blanket of fire wrap around my body, and everything just happened in a matter of seconds from there," Davis said in an Army news release.. "But before I could get the other half of her body out, she caught fire from all the fuel that was on her. I noticed she was on fire [shortly] before noticing that I was on fire too."
It was a normal summer day on June 9, 2017 when Staff Sgt. Nicholas Davis, C Battery, 1st Battalion, 320th Field Artillery Regiment, 101st Airborne Artillery cannon crew member and section chief, was driving home to Ellijay, Ga., from Fort Campbell in Kentucky.
As he was cruising down the road near Nashville, he noticed a car overturned on its passenger side. It had flipped almost completely over, coming to rest on a slight downward slope, reported the Atlanta Journal-Constitution. Few other drivers seemed concerned, according to the Army.
"I was pulling up, and I noticed there was a small engine fire underneath the belly of the car, so I jumped out and ran up to the vehicle," Davis said.
When he reached the car, he found two people, Rick and Sharon Steiert, trapped in the vehicle. Most distressingly, a can of fuel that had been in the back of the car had tumbled during the crash. It had now become wedged under Sharon's legs, and she was covered in gasoline.
Sometimes Heroes Need Help Too!
There seems to be a lot of confusion about something that should not confuse anyone after all these years. Human beings are not helpless because others are there to help them.
Those others, you, pay a deeper price than anyone else. For you, it is a matter of facing life or death situations over and over again because you chose it as your job to do.
When you are one of those rare ones putting the lives of others ahead of your own, that is what a hero does. Sure, you may get uncomfortable with that word and think of others you served with as more worthy of that title, but to the rest of us, that is exactly what you are.
There is a price you pay for what is inside of you. The same courage that made you want to do that job in the first place, is waiting for you to have the courage to ask for help. In other words, it may be time to call for backup!
If you see yourself as a victim, then you may be not even thinking of that in the right way. Do you feel the "victims" you risked your life for were worthy of the effort? After all, you managed to be there so they went from "victim" to survivor. Didn't you?
If what caused the PTSD did not win when it happened, then why let it defeat you now? You are a survivor of what happened yesterday and it became part of you but did not change you. It changed the way you think about yourself and others. It did not change "who you are" even though it changed "how you are" but you are in control of what you make out of what it is trying to do.
Someone told you a lie that may have made sense but if they told you PTSD is based on weakness, not being tough enough to take it, then they don't know what they are talking about. It is because you have a much stronger emotional core than they do. Maybe they are just jealous of that quality you have, then again, maybe they are only covering up their own pain because someone else told them that same lie.
Look up most of the Medal of Honor recipients who openly talked about what their actions did to them and how they battled PTSD as hard as they fought to save lives on the line.
When you walk away from "IT" you do not just carry your own pain. You carry the pain of others. Often they are not even people you know. Most of the time they are the one too many strangers you saw suffering, that piled onto all the others you encountered.
So please, ask yourself a very important question. "If life mattered so much to you, you risked your own for their sake, then why doesn't your life matter to you?" Are you willing to turn to the very people you know would have died for you and trust them?
You only have PTSD because you survived "IT" so stop thinking it defeated you. Stop being your own worst enemy and start being a hero in your own story. After all, if you think you are the only one you were with suffering, all you need to do is take an honest look at them and see the pain in their eyes. You know, the same pain you see when you look in the mirror.
What are you waiting for? This time the life you save needs to be your own!
"Spreading the message that the heroes saving lives everyday, sometimes need help themselves. 'It reminds you that you are out there doing good. We didn't do anything to cause any of those tragedies to occur, but we did the best we could.'"
"Terry Wayne Ward, age 71, of DeMotte, IN, escaped this mortal realm on Tuesday, January 23rd, 2018, leaving behind 32 jars of Miracle Whip, 17 boxes of Hamburger Helper and multitudes of other random items that would prove helpful in the event of a zombie apocalypse."
DEMOTTE, Ind. – A northwest Indiana woman decided the style of traditional obituaries didn't quite fit her dad's personality, so she wrote up one that did.
"He lived to make other people laugh…it was the only way to honor him properly," said daughter, Jean Lahn, of Lowell.
Terry Ward moved to Demotte from suburban Illinois in 1973 after serving in the Vietnam War. The Army veteran wanted a quiet place in the country after participating in active combat.
During her work at Geisen Funeral Home, she has seen her fair share of stale obituaries, usually set up the the exact same way.
"I wrote it myself and I didn't tell anyone I was going to make it funny," Jean said.
After reading it, the rest of her family said it was perfect and shared many laughs.
Larry "Smiley" Kleiman, who did two tours in Vietnam, had almost no natural teeth left when he saw Dr. Michael Tischler, founder of the Teeth Tomorrow franchise network, for a consultation.
"He smiled, he had no teeth. His his name was Smiley, he was a fireman. He worked with dogs in Vietnam. And everything about him was just the kind of person that you wanna help," Tischler said.
Top guns in tears: The bravest and the best yet weeping and traumatised, war heroes say they have nowhere to turn for help - will the MoD heed their call?
"My experiences have also made me a much more emotional person and tears can flow at the simplest of triggers such as Remembrance Sunday, when I recall the friends I have lost. In those moments I take solace that at least I understand what is happening to me – the processes of PTSD and how it shows its teeth."
Twenty-seven years ago I was shot down over Iraq, captured, tortured and forced by Saddam Hussein's henchmen to appear on television to denounce my actions as an RAF officer.
Images of my bruised face flashed across the world and became a lasting image of the horrors of the 1991 Gulf War.
As a prisoner of war, I felt like the most insignificant, terrified human being on Earth.
The memories of my abuse and brushes with death are still with me. Dealing with Post-Traumatic Stress Disorder (PTSD) has become part of my life.
For this reason I am backing The Mail on Sunday's campaign to improve mental healthcare for serving troops, including the introduction of a 24/7 helpline.
I feel the pain of those worst affected by PTSD. As someone who has experienced it myself, I understand what they are going through and the confusion they can face. I can be enjoying a perfectly normal day or night when a sensory stimulus, or trigger, fires me back into my past.
For me it is primarily noise – loud bangs, fireworks going off, trains going past, all these sound like the Coalition jets that flew missions over Baghdad attacking several of the buildings we were held in.
"War hero and Internet activist — it's the dichotomy that made up the complicated life of James Dolan."
The ambulances and police cars came to a screeching halt outside the Gowanus Inn and Yard, a hip, ultramodern hotel that had recently opened on an edgy strip of Union Street in Brooklyn.
But the first responders were 48 hours late. James Dolan, a 36-year-old former Marine and computer security expert, had hanged himself in his room two days before, on Dec. 26, according to the NYPD.
"There is more than one way to self-destruct, of course. Some people kill themselves in a single act, others in installments. Their sense of purpose and self-worth evaporates; they stop caring whether they live or die until, eventually, they are beyond reach."
Former Army sergeant Calum MacLeod was in an Irish American bar in Germany when he suffered the flashback that forced him to face up to his post-traumatic stress disorder (PTSD). With hindsight, he accepts he had been struggling for a long time.
Ever since he had been attacked while serving with the King's Own Scottish Borderers in Northern Ireland in 1992, he had suffered nightmares, which he countered with heavy drinking. Back then, a crowd of youths had cornered him in an alleyway, hit him over the head with a concrete slab and stolen his gun. When he regained consciousness in a hospital in Belfast, he was told one of the youths had pointed the weapon at his head and fired, but the mechanism had jammed, so he survived.
MacLeod, from Hamilton, ended up in a psychiatric hospital where a colonel told him he was suffering from one of the worst cases of PTSD he had ever seen. Posted back to the UK and unable to cope with confined spaces, he pioneered a successful scheme to help would-be Army recruits reach the required level of fitness. But, in 2011, after 23 years of service, he decided it was finally time to call it a day.
I finally did what one of my co-workers has been after me to do for a long time. Now I can go into work on Monday and say, "Yes I did publicize how long I've been doing this."
I got into the healing business of Combat related PTSD back into 1982. Yes, I am that old. My Dad was a Korean Veteran and my uncles were WWII veterans. On the night my Dad met my then, Vietnam veteran boyfriend, he said "He seems like a nice guy, but he's got shell shock." Never heard that term before. When I asked what it meant, he said "It has to do with war" but he couldn't explain it. He told me to go to the library.
Basically, he started this but the man I fell in love with and married back in 1984 kept me going ever since.
I am sure you've read about the rants I do regarding reporters not doing their jobs and the awareness raisers taking the easy way out on all of this, but now you'll know why I get so angry.
Two years after researching PTSD, I finally knew enough to write about it. It was mostly in local newspapers. Then I got on the phone to get reporters involved with what families like mine were going through. They ignored all of it.
In 1993, it was doing online research and writing and there were a lot more like me out there. I learned from them and they learned from me too.
My first book "For the Love of Jack" was done in 2000 but I couldn't find a publisher. It was self published 2003.
Wounded Minds is one of the first videos I created back in 2006. I spent a long time going through files to find some of the older ones that used to be up on YouTube. Here are some of them that may prove the point, that taking the easy way out on taking care of our veterans, has been the reason we have lost so many of them. You can watch a couple of hundred more here.
Want to stop supporting people in the business of having fun with talking about suicides or do you want to start publicizing people in the business of healing?
I have a lot of emails saved on what this work meant and the fact that regular people like me can make a huge difference if we take the time to actually learn what this is.
Kathie, You may be receiving an E-mail from the 'Huffington Post - Contagious Videos' as I just Registered your video 'Wounded Minds'!!
I posted your name and e-mail on the online registration form, I think you should post the video up there, Hell even All of them, which I just Viewed and will pass on!
Hope you don't mind me taking the Liberty of writing them for you, if so just let me know!
THANKS for putting these together, I'll post them up on my blog: http://imagineaworldof.blogspot.com/ along with LinkBacks to your site and blog, and will be passing All of them on to as many as possible!!!
Seven years ago, Michael Gaither felt hopeless. Long after his military service in Vietnam, he was still traumatized and suffering. He didn't want to see his children. He drew the curtains and locked the doors of his Chiefland home.
This is how he planned to spend the rest of his life.
Then came Honey, a full mobility and post-traumatic stress disorder medical service dog.
Gaither and Honey met through a research project conducted by the Veterans Administration that pairs medical service dogs and veterans with PTSD.
For the past seven years Honey has given Gaither physical and emotional support. She helps the 72-year-old dress every morning, picks up anything he drops and comforts him when he has night terrors.
Both Gaither and Honey are terminally ill. Besides PTSD, Gaither has multiple sclerosis and osteoporosis. He's currently in hospice care at Malcom Randall VA Medical Center.
"Honey takes his mind off all that," said Gaither's wife, Kaye, 75.
Honey is affected by aspergillus, a fungal infection that no amount of antibiotics has been able to quell. She's being treated at the UF Small Animal Hospital with the integrative medicine service.
For as long as humans have walked this earth, there has been a risk that they would experience a traumatic event. For some, traumatic events create psychological effects that will last for months after the initial event.
The "Courage Without Fear" exhibit is now on display at the Tri-Cities Historical Museum, 200 Washington Ave. in downtown Grand Haven.
Today, this is commonly referred to as post-traumatic stress disorder (PTSD). According to the American Psychiatric Association, about 3.5 percent of adults in the U.S. will experience PTSD in a given year and 9 percent of people will develop it at some point in their life.
For those who have served in the armed forces, that number is even higher. The Department of Veterans Affairs estimates that 10-18 percent of veterans who have served in Iraq or Afghanistan are likely to develop PTSD after coming home. For some, PTSD can lead to substance abuse or other issues. The good news is that veterans are now seeking care more than ever.
Earlier this month, the Tri-Cities Historical Museum opened a new exhibit titled "Courage Without Fear: The Red Arrow Division in World War I." This new exhibit uses first-hand accounts to tell the stories of local soldiers who braved muddy trenches, attacks on machine gun nests and hours-long artillery barrages during the war. Men from the Tri-Cities saw combat in some of the most intense battles of late World War I, including the famous Meuse-Argonne offensive that sealed victory for the Allies.
In 1915, the British Army Council gave in to the doctors and public sentiment and officially declared shell shock as a wound.
Early on in the war, British doctors tried a variety of treatments, including hypnosis, in an attempt to keep as many soldiers on the front lines as possible. As the war dragged on, the British Army continued to change procedures for how doctors could diagnose and treat shell shock. By 1917, soldiers were treated by being assigned to a rearward trench where they could get a break from battle, sleep and eat in relative comfort. After a short break, they would return to the front. A full evacuation of a shell-shocked soldier was only considered if no improvement was seen after several weeks of treatment. This style of treatment was used until the end of the war in 1918 and was seen as effective by the medical community and the army alike.
Unfortunately, following World War I, there was a collective silence in regards to shell shock. Many of the survivors feared a rekindling of their symptoms if they discussed their war experiences. In the medical community, hardly anything was published on the causes of shell shock or ways to improve treatment. It wasn't until decades later, in 1952, that "gross stress reaction" was added to the Diagnostic and Statistical Manual of Mental Disorders. In the 1970s, PTSD became the commonly accepted term.
Staff Sgt. Vuong said he was just upholding his Marine pledge of honor, courage and commitment.
SAN DIEGO (NEWS 8) – A special honor Friday for a San Diego Marine who was in the right place at the right time to save a life.
Staff Sergeant Hai Vuong Rushed into action when two semi-trucks collided on a San Bernardino freeway last November – pulling one of the drivers to safety.
Staff Sgt. Vuong was honored with the Liberty Mutual Insurance Lifesaver award for his heroic actions. "I just happened to be there at the right time and the right place," he said.
Staff Sgt. Vuong was driving on Interstate-15 in San Bernardino with his family when the two semi-trucks collided. He was able to safely pull over and rescue one of the drivers.
Vuong said he could smell fuel leaking into the cab and feared it could explode. The driver had a gash on his head was bleeding.
New Hampshire Hospital for the mentally ill is prison?
CONCORD — Two mothers told lawmakers their daughters are harassed, humiliated, and sometimes "locked down" at the Secure Psychiatric Unit at the New Hampshire Prison for Men, and a former patient recounted nearly dying as his pleas for emergency medical care were ignored.
The Secure Psychiatric Unit has stirred controversy because mentally ill people are held there if they haven't committed a crime, but are considered too dangerous to be housed at the New Hampshire Hospital for the mentally ill.
At SPU, civilly committed patients who were found not guilty by reason of insanity and not competent to stand trial are commingled with convicted criminals who are mentally ill in a 60-bed unit on the grounds of the men's prison. Presently, three women and one person who is transitioning from male to female, are housed in the unit on the prison campus with about 1,400 men.
"My daughter has been in SPU (Secure Psychiatric Unit) for three years," said Cindy Glazier. "I can visit on weekends. That's it. It's a prison setting, not a psychiatric unit. It's not for patients. She's treated like a prisoner and it's not set up as a hospital.
Glazier's daughter, Patina Welch, pleaded not guilty by reason of insanity in 2015 to jumping out a second-story window in Lyman holding her 4-month-old boy-girl twins, killing her son and injuring her daughter the summer before. Welch told police she was trying to save them from armed intruders.
The prosecutor at the time said there was clear and convincing evidence that Welch suffered from a mental disease or defect. Welch was diagnosed with schizoaffective disorder, bipolar disorder, post-traumatic stress disorder and personality disorder.
A former London firefighter has opened up about how his dream job spiralled into a nightmare when years of trauma finally caught up with him.
Now a BBC journalist, Clifford Thompson was a London Fire Brigade officer for half a decade.
From 1987 to 1992 he tackled some of the capital's most devastating events, including the King's Cross tube tragedy and the Clapham rail crash.
But after five years in the brigade, Cliff's world collapsed when he watched a three-year-old boy he rescued from a house fire die before his eyes.
The body of 69-year-old Dennis Reidy was found Tuesday in the corner of a park in Lexington. Coroner Margaret Fisher tells WYFF-TV that Reidy was found in "a type of garage storage box" wearing a South Carolina Gamecocks jacket.
It's a picture that tells a story of loneliness, hopelessness, despair. In the quiet corner of a Lexington park is the place where a homeless veteran lived and died.
A 15-year-old discovered the body of 69-year-old Dennis E. Reidy there on Tuesday.
"Lying in, basically, a type of garage storage box," said Lexington County Coroner Margaret Fisher.
It's a case that brings tears to Fisher's eyes. Since Tuesday, she's discovered Reidy was a Vietnam War veteran, a Richland County deputy from 1978 to 1990, and a University of South Carolina grad.
But what's more unforgettable to Fisher is where he was found. His body was found on Chariot Street, which is just a short walk from a shelter for homeless veterans where James Wardlaw, who goes by J.W., is outreach manager.
Reporter failed to Google what he was told about PTSD by Army?
In keeping with holding reporters accountable for what they report, we have another example of a reporter failing the subjects. Just think, with all the stuff popping out, reporters get paid to do it?
Looks like the Jeremy Schwartz of American Statesman Staff decided to not even read the report they just released, or even ask any questions regarding proof of healing.
First, here are the numbers of soldiers reported as suicides by the Department of Defense.
In 2015, 120 Soldiers committed suicide and 55 Army Reservists and 104 Army National Guards.
In 2016, 130 Soldiers committed suicide and 41 Army Reservists and 109 Army National Guards.
Up to the first half of 2017, it was 55 Soldiers, 31 Army Reservists and 62 Army National Guards.
All in all, when you factor in the other thing the DOD said would also work, called "resilience" training, we see how this reported "progress" is repeating what has not worked.
"The study, the first-ever randomized clinical trial of prolonged exposure therapy with active-duty military personnel and the largest study yet of prolonged exposure therapy, was carried out by researchers affiliated with the STRONG STAR Consortium, a multi-institutional research network funded by the Defense Department aimed at researching combat-related PTSD treatments."
In 2016, STRONG STAR announced the results of another Fort Hood study that found 12 sessions of therapy led to PTSD recovery in 40 to 50 percent of soldiers. Instead of confronting traumatic memories directly as in prolonged exposure therapy, cognitive processing therapy helps patients learn to think about their traumatic experiences in a clearer way, without "distorted thoughts" that perpetuate feelings of guilt, blame and anger, researchers said.
Which is it? The first ever or the second one?
What makes this even more frustrating is this piece of news that must have just been too hard to Google to know if he was told anything close to the truth.
This is from 2015 when a veteran had experienced this therapy. He should know because he is a veteran and had this therapy in 2013.
The "gold standard" treatment for PTSD makes many vets' symptoms even worse.
The problem with prolonged exposure is that it also has made a number of veterans violent, suicidal, and depressed, and it has a dropout rate that some researchers put at more than 50 percent, the highest dropout rate of any PTSD therapy that has been widely studied so far.
Perhaps a better example of how this does not work, is the research done in 2006 Do You Need To Talk About It? Prolonged Exposure for the Treatment of Chronic PTSD referencing the benefits along with the dates of how long this research has been studied. It goes back to the 90's.
If it worked, then it would have worked and we would not have seen the results we have when the suicide rate of our veterans has gone up, along with the number of service members throughout all branches.


The chief of staff to President Hassan Rouhani said Wednesday that US President Donald Trump's people asked for a meeting with Rouhani eight times during the UN General Assembly last year.
"During Mr. Rouhani's last visit to New York for the UN General Assembly, President Trump's office eight times conveyed to the Iranian delegation a call to have a meeting with the president," Mahmoud Vaezi told reporters, according to Mehr News Agency.
He said the Iranian team did not respond to the requests, which came just after Trump announced he would no longer certify Iran's compliance with the 2015 nuclear deal–setting the scene for his eventual withdrawal from the pact in May.
"We have a transparent policy and clear position with regard to our relations with the US... that (we) will not yield to pressure," Vaezi said.
Tehran said in October that the Trump White House had requested talks with Rouhani during the annual UNGA meeting. However, the claim of several requests had never been made.
The embattled US president has said he is open to talks on a new deal with Iran that goes beyond its nuclear program to include its regional policies and missile defense systems. Iran has said that the two key subjects are not negotiable.


text:
Here comes Indonesia's sea toll road: The Jakarta Post
A crane moving a container at the Koja Container Terminal near Tanjung Priok port in Jakarta, on Aug 4, 2015.PHOTO: REUTERS
Nov 11, 2015, 11:57 am SGT
http://str.sg/ZEj8
In its editorial on Nov 11, 2015, The Jakarta Post says new seaport facilities will improve trade.
Last week, the government launched its so-called sea toll road transportation program, which connects Jakarta's seaport of Tanjung Priok and Surabaya's Tanjung Perak in East Java with major ports in Maluku and Papua, in the eastern part of the country, and in Riau Islands.
Not many newspapers paid much attention to the launching of the maritime freight service by the ministers of trade and transportation at Tanjung Priok. But the program is actually vital for a vast archipelagic country such as Indonesia, where seaports are key to facilitating the smooth distribution of goods.
President Joko "Jokowi" Widodo has rightly put inter-island connectivity at the top of his development priorities under the sea toll road program.
As part of this program, the government also has put a great deal of resources into improving the performance of seaports to cut down dwelling times for cargo vessels.
The acute lack of regular inter-island freighter services and inefficient port handling are one of the main causes of the high logistics costs in the country.
The freight service program launched last Wednesday initially runs only three freighters plying three routes between the two largest ports in Java and a dozen ports in Papua, Maluku and Riau Islands.
But the transportation minister has instructed state-owned shipping company Pelni to order six more inter-island freighters to increase the frequency of services between those ports.
The government has also made the right decision to initially subsidize the freight rates charged by Pelni on the routes covered under the program, so that the service will be able to run regularly even though the load factor will initially be very low.
The subsidised freighter service facilitates the realisation of the "trade follows the ship" principle.
This means that after a few months, the regular freighter service will eventually attract the attention of shippers, traders and manufacturers and encourage them to use the services. And as the load factor increases, Pelni will no longer need subsidies for that service.
The experiences of many other countries have shown that implementing the "trade follows the ship" concept is a much more effective and efficient way to invigorate sea transportation services than waiting first for the availability of sufficient volumes of cargo on particular routes before ships ply those routes under the so-called 'ship follows the trade' concept.
Efficient maritime transportation is indeed a prerequisite to developing efficient supply chains within the vast archipelago, and another vital component of this service is efficient seaports, because smooth sea transportation will contribute to strengthening the overall competitiveness of the economy.
Superb seaport performance will unleash the country's vast economic potential, because shipping lines and business in general will benefit from improved logistics and the reduced costs of supply chains.
Improving supply chain flows with a focus on developing domestic port infrastructure and capacity is therefore imperative.
* The Jakarta Post is a member of The Straits Times media partner Asia News Network, a grouping of 22 newspapers seeking to promote coverage of Asian affairs.


Every July, teachers from South Georgia eagerly await the #KickOff event hosted by Teacher's Harvest. Teacher's Harvest is a subsidiary program of Second Harvest of South Georgia, Inc.
Businesses and foundations donate various school supplies and equipment to the Teacher's Harvest store. Teachers can then shop for free school supplies. You heard me right – FREE SCHOOL SUPPLIES!
There's no catch. Educators from their region need only provide proof that they are a teacher, counselor, or media specialist in a public school to be able to shop.
Since their inception, Teacher's Harvest has served thousands of teachers with almost $4 million in school supplies. (I can't help but see Dr. Evil saying $4 million dollars. Ha!) Seriously though, that's a ton of pencils, paper, staples, scissors, and book bags.
Teacher's Harvest isn't limited to just those supplies. I've personally gotten two very nice 31 tote bags, a giant dry erase board, sticky notes, chapter books, glue sticks, pocket folders, markers, and colored pencils – just to name a few items! The Yoobi classroom boxes are the best!
If you want to know more, check out their Teachers' Harvest web page or find them on Facebook @SecondHarvestSGA.
*Some images used from Yoobi and @SecondHarvestSGA. No copyright infringement is intended.
Back to School Giveaway at the Coop!
Copyright ©2018 TeacherMood - All rights reserved.


This is supervisory work involving general maintenance of parks and recreation facilities.
An employee in this class is responsible for supervising and, as necessary, participating in general maintenance, irrigation and aquatic, repairs general parks and recreation equipment and repair. Tasks, which are of more than average difficulty, are performed in accordance with established practices and procedures and include performance appraisals, recommending hiring and promotions, and discipline administration for the employees supervised. Work in some positions requires that the employee maintain accurate records in order to ensure proper billing of user departments. Employee is also expected to make accurate cost estimates and complete supply requisitions. Under general supervision, the employee is required to exercise reasonable initiative and independent judgment in determining maintenance requirements and ensuring timely completion of work projects. Work is reviewed while in progress and upon completion through observation, conferences, reports submitted, and results obtained.
Plans, organizes, and controls all phases of the work program for maintenance personnel; assigns employees to jobs based on what each is qualified to do; supervises all maintenance personnel in performance of duties; transports material and personnel to assigned work areas; maintains work schedules and a log of work accomplished; checks the progress and quality of work performed.
Performs detailed area surveys to determine maintenance requirements; writes work orders on scheduled items; prepares estimated cost of repairs for budget purposes; receives work orders; estimates needed materials and orders; reviews bill for labor and material; inspects completed repairs prior to submitting for payment; makes final inspection on completed work.
Performs and supervises: electrical, metal, irrigation and aquatic repairs and installation, masonry and/or carpentry work, cutting and welding.
Performs carpentry layout work and assists in actual work as required; designs sidewalks, signs, and displays; cuts glass.
Checks all emergency repairs and decides what action should be taken; reviews work upon completion.
Directs all fountains on city contracts; reviews work involving contracts with prospective bidders, inspects work done, review and approves all required repairs.
Plans the expansion of the central control system for irrigation and lighting; oversees the programming and repair of all central control components.
Maintains written records of payroll for all maintenance personnel as well as records of sick leave and vacation schedules; keeps records of maintenance performed; maintains construction costs on various projects; maintains building files including labor tickets purchase orders and contracts; updates billing catalog.
Communicates with manager on all important issues concerning performance of the maintenance department, i.e. additional employees, vehicles, equipment, promotions; coordinates daily work requests and special city-wide programs with all supervisors; consults with department heads and other regarding feasibility of proposed renovations and alterations.
Enforces and practices safety for all employees; ensures upkeep and proper use and care of all vehicles, tools, and equipment; assumes duties and responsibility of superintendent as required.
Considerable knowledge of: maintenance, repair, and layout of parks and recreation area; methods, tools, and techniques used in maintenance and repair work related to assigned area; occupational hazards and appropriate safety precautions.
Ability to: supervise, perform, and review a wide variety of assignments associated with the maintenance and repair trade; interpret drawings and blueprints and to estimate materials needed; maintain records and compile reports; establish and maintain effective working relationships with employees and the general public.
Skill in: use and care of hand tools, power tools, pumps, and other related equipment.
Graduation from an accredited high school or vocation school and three (3) years of experience in general maintenance, irrigation and aquatics, including six (6) months in supervisory experience; or an equivalent combination of training and experience.
Possession of a valid Florida driver's license required; a Commercial driver's license may be required.
Possession of or ability to obtain within one (1) year of employment: Certified Playground Safety Inspector, Aquatics Facility Operator.


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You are here: Home / Music / Classical Music / Classical Album Review: Sibelius Tone Poems — Focused and Bold Performances
Classical Album Review: Sibelius Tone Poems — Focused and Bold Performances
By Jonathan Blumhofer
The Norwegian soprano's execution of the vocal line in Luonnotar is nothing short of astounding.
It's rare that a recording of a single, fairly obscure, short tone poem by Jean Sibelius should send you rushing to the record store (or iTunes or Spotify). But this disc – a compilation, in fact, of offbeat Sibelius tone poems – is just such a one. And that owes entirely to Lise Davidsen's magnificent account of the Finnish master's Luonnotar.
A setting of the creation myth as recounted in the Finnish Kalevala, this 1913 essay is at once austere and profoundly soulful. Known as one of the most challenging vocal works in the repertoire – its range covers two octaves and it's full of perilous leaps – the list of singers who own the piece is small. Now add Davidsen to their ranks.
The Norwegian soprano's execution of the vocal line here is nothing short of astounding. She sings with breathtaking clarity: every element – diction, tone, vibrato (or lack thereof) – is perfectly calibrated. The evenness of Davidsen's projection, too, is simply amazing. She floats the pianissimo C-flats like there's nothing easier to do and drills the climactic one with a potency that's fully worthy of Birgit Nilsson in her prime.
Simply put, this is the best Luonnotar I've heard — and that's before you take into account the exceptional — expressively cool but rhythmically tight, smartly paced, well-balanced, blazingly colorful – accompaniments Edward Gardner draws from the Bergen Philharmonic Orchestra (BPO).
The rest of the album is, if not quite as thrilling as Luonnotar, at least as focused and bold.
Gardner leads a taut, driven account of Tapiola, Sibelius' enigmatic final major orchestral work. Its dissonances speak imperatively (and resonantly), even if the brasses are a hair overwhelming during the music's raving climaxes.
Restraint and clarity are the themes in the BPO's account of Sibelius's 1905 Pelléas et Mélisande Suite. Written to accompany a Finnish production of Maeterlinck's play, it's music of much charm as well as heart.
Highlights of the present performance include a discreet "Mélisande," with its seductive waltz patterns and lovely English horn solos; Davidsen singing "The Three Blind Sisters"; a menacing "Mélisande at the Spinning Wheel"; and a rich-toned, unsentimental reading of "Mélisande's Death."
Likewise austere is Rakastava, Sibelius's 1912 reworking of an a capella song cycle for strings and percussion. Written around the same time as the bleak Fourth Symphony, Rakastava shares with the larger work a certain concision and directness that's perhaps best channeled in the BPO's delicate and lean playing during its diaphanous second movement.
Filling out the recording is a notably fresh and purposeful account of the 1894 tone poem Spring Song. Gardner leads the BPO in a reading that's nicely blended, shaped, and colored. Tempos move. All of this serves to distract from the music's repetitious and bombastic elements. The results are, for once, aptly radiant.
Jonathan Blumhofer is a composer and violist who has been active in the greater Boston area since 2004. His music has received numerous awards and been performed by various ensembles, including the American Composers Orchestra, Kiev Philharmonic, Camerata Chicago, Xanthos Ensemble, and Juventas New Music Group. Since receiving his doctorate from Boston University in 2010, Jon has taught at Clark University, Worcester Polytechnic Institute, and online for the University of Phoenix, in addition to writing music criticism for the Worcester Telegram & Gazette.
By: Jonathan Blumhofer Filed Under: Classical Music, Featured, Music, Review Tagged: "Sibelius", Bergen Philharmonic Orchestra, Bergen Philharmonic Orchestra (BPO)., Chandos, Edward Gardner, Lise Davidsen


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Hoevenen est une section de la commune belge de Stabroek située en Région flamande dans la province d'Anvers.

Commune avant fusion dans l'arrondissement d'Anvers
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"ALONG with a handful of friends and family who volunteered weekly, we helped about 100 women that first year," remembers Karmen Masson, Executive Director of Edmonton-based charitable organization "Suit Yourself." She was referring to 2002, when she set up a makeshift refuge for low-income women seeking employment or transitioning into the workforce, and in need of free quality clothing.
"My parents used to own a 90-year-old walk-up apartment building in the downtown area," explains Masson, "and there was a vacant space in the basement." That's where Masson, a full-time lawyer and mother, began collecting and distributing professional, fashionable, and free clothes for a cause unique to our city, one that might have you wondering, "Why didn't anyone think of this before?!"
"Over 10 years ago I was looking to create some good karma in my life," Masson continues. "I was leaving a bad relationship and trying to devote my energies into doing good for others. I was searching for a volunteer activity that would supplement my career as a lawyer and exercise my creative talents. I loved clothes and fashion, and I realized as a young lawyer at that time that I felt more confident and respected when I was well dressed."
Since those humble beginnings, Masson was able to upgrade from her folks' basement boutique to "an underpopulated school in a central location that was willing to lease us a classroom for an affordable rate," and finally--as of Fall '09--into a street-front commercial space in Little Italy. "My dreams had come true!"
And it's that vision that has allowed the dreams of other local women to come true, too.
"I love hearing from clients about their success stories," Masson says. "One woman told me that she was so inspired by the volunteers who suited her, that she called a former employer and asked if they had any job opportunities. Her former boss offered her a job, and when her wage was discussed, she felt confident enough to ask for a substantial increase in salary...and they gave it to her!"
These are the kinds of stories that occur on a regular basis, because of Masson and the volunteers over at "Suit Yourself" (10746-95 St./ 780-488-9930), which is why it's vital to keep their doors open. This Saturday (May 28) professional image consultant Joanne Blake and her "Style Power" team will host a "Clothing Swap & Silent Auction" from 11AM to 4PM, at the Quality Inn (West Harvest) on 178th Street and Stoney Plain Road.
"They have called it a clothing swap, but they are simply collecting quality business attire and accessories in advance of the event, and then they will be selling the items for very reasonable prices." All of the proceeds will be donated to "Suit Yourself."
To donate or attend the "Clothing Swap & Silent Auction," call Paula at 780-701-2990, or contact her via email at paula@creatingpeoplepower.ca.
Below is a video clip from the CBC, featuring Masson and 'Suit Yourself,' from 2010.


Buck Chamois:8-10 inch bucks of a good size, many will average a good trophy (SCI) score. You might see an average of 5-15 chamois per day with 1-2 bucks or more on a good day.
Ranches: Are up to 6,000 acres and comprise of both open tussock country with some bush clad valleys. The properties rise from 1,500 ft. to over 6,000 ft. and offer probably the best traditional chamois hunting. You can also find Red Stag, Fallow, Tahr, Ram, Goat and Boar all on privately managed ranches in the South Island of New Zealand.
Access: Is by 4x4 vehicle that provides you with good access to most of the ranch during the hunt by way of some safe 4x4 roads up the mountain. However, not all roads can be used after heavy rain or snow.
Accommodation: About a 2 1/2 hour drive from Christchurch airport is our Ranch House which caters for up to six guests at any one time. You have access to a washer/dryer and there is phone/fax/internet in the lodge along with some cell service, these are between 5 and 25 minutes away from all our prime hunting areas.
Other Game Animals:You can include other big game animals on this hunt as the ranches have free range Red Stags, Bull Tahr 10-13" and Fallow bucks up to 200 SCI. Then in the game ranch are Elk, NZ Wapiti, larger Red Stags, Fallow, Tahr, Chamois, Goat, Ram and Boar.
Licenses and Tags are not required.
Guides don't normally turn lips and ears or salt skins. The taxidermist in Christchurch will do this plus salt, dry and pack hides, skulls, antlers and horns, do the documentation and ship to your taxidermist in the U.S. Taxidermist will also mount all animals and ship to you within twelve months. Expediting fees of approx $600 to $800US for each animal which has about a 4 month turn around.
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