text:
The Poggio Civitate Archaeological Project – 2023 Field Season
Location: 53016 Murlo, Province of Siena, Italy
Season: June 28, 2023 to August 3, 2022
Website: http://www.poggiocivitate.org
Anthony Tuck
The 2023 field season marks the 58th year of archaeological exploration at Poggio Civitate (Italian for "Hill of the Civilization") located in central inland Tuscany. Excavation began in 1966 under the direction of Dr. Kyle M. Phillips, Jr. of Bryn Mawr College. Work continued under the direction of his student, Dr. Erik Nielsen, and is currently lead by Dr. Anthony Tuck of UMass Amherst. The excavations have brought to light a large volume of material from distinct phases of Etruscan occupation. A brief summary of this work is provided below. For further material and articles related to the site, please see the excavation database website.
The Poggio Civitate Archaeological Field School is among the oldest and most respected archaeological programs in the world. Our training provides students and archaeology enthusiasts the opportunity to excavate at the site under the direction of a staff of professional archaeologists, conservators, illustrators, and photographers. Participants receive training in all aspects of fieldwork, including excavation and data collection, archaeological survey and drawing, objects conservation, illustration, photography, and cataloguing.
At Poggio Civitate, we believe that the best field experience is comprehensive. Students are encouraged to work directly with directors of excavation units, follow artifacts from discovery through conservation and into cataloguing. Most of our participants come with no field work experience – many have never even taken an archaeology or classics course –and by the end of the season, we believe, each comes away with a foundation in Etruscan Archaeology and field methods, as well as a rich appreciation for Italy and rural Italian culture.
Work on site or in the laboratory (called the Magazzino) will constitute the majority of your "classroom" experience. Participants will work side by side with professional archaeologists, conservators and other members of the excavation team on projects integral to the functioning of the dig as a whole. While the majority of this time will be spent on the hill, working in the trenches, there is a weekly rotation into the magazzino where students will work in conservation, data entry, photography, cataloguing or illustration.
Fieldwork and excavation experiences are supplemented by lectures and a more traditional educational program. Weekly lectures by Professor Tuck or other members of the excavation staff cover a broad range of topics, from a general history of Etruria to the Social and Political implications of Bucchero pottery from Poggio Civitate. Visits to the museum that houses material from our excavation, as well as other regional museums occur frequently. There is also ample free time, including weekends, for participants to explore the Commune of Murlo, Tuscany, and further afield in Italy.
Period(s) of Occupation: Etruscan - Roman - Orientalizing - Pre-Roman Italy
Project Size: 50+ participants
Experience Required: None
6 Credit Hours - UMass Amherst
Jason Bauer
125 W 3rd 2B
digmurlo@gmail.com


text:
Law amendments affect thousands
Aleksei Gunter
TALLINN - Amendments to the law on deportation and entry refusal approved June 26 violate international human rights and potentially harm up to 80,000 people living in Estonia, according to experts from the Legal Information Center for Human Rights.
The people who would suffer are those without any legal basis for residing in Estonia, namely people who did not get residence permits in the mid-1990s when they were first issued, or those who still have old Soviet passports or no documents at all.
Data from the LICHR says those people number about 80,000, while information from the Citizenship and Migration Board maintains the number is closer to 30,000.
Andrei Aryupin, head of the center's legal aid department, told The Baltic Times that the new amendments do not correspond with present legal practice and regulations in Estonia.
For example, a person could be asked to leave the country if his residence permit expired. He or she has 90 days to obtain legal status (get a residence permit) through the courts, failing which the person has to leave the country and continue applying for the residence permit from abroad.
"Legal practice shows it takes at least a year to examine one's residence permit application," said Aryupin. "If a person does not have any citizenship, he or she cannot be deported. Many people come from the former Soviet Union, a country that does not exist anymore, but they have families, relatives and jobs here."
Another unfair provision, continued Aryupin, is that when a person fails to obtain legal residence in 90 days, that person has to pay a sum of up to 10,000 kroons ($550) - called "compulsory money" in the amendments - to the Citizenship and Migration Board. The sum equals almost two average monthly salaries in Estonia.
"We have a situation where those people will have to pay the fine anyway, because they won't manage to get a residence permit in three months," said Aryupin.
He added the amendments also practically remove court control of the deportation process. "Now (Citizenship and Migration Board) officials, who are often incompetent, can issue deportation orders at will," said Aryupin.
The board can officially extend the term of examining certain residence permit applications to up to 18 months, and simply force people to pay.
However the provision on compulsory money obtains legal force only from next January.
"These amendments are more like those for a Third World republic than a state that is longing to become a part of a united Europe. Neglecting the rule of law principle might be even an argument for slowing down the process of negotiations between Estonia and the EU," concluded Aryupin.
Heikki Kirotar, spokesman for the Citizenship and Migration Board, said it will take from six to seven months to extend a residence permit if its holder used to have an alien passport. "Those people have never been deported and never would be," he said.
Stephan Heidenhain, legal adviser for the OSCE mission to Estonia, said the OSCE has always kept an eye on the law on aliens and the law on deportation and entry refusal, and that the new amendments are a way to legalize instead of prompt deportations.
"This is an improvement. But it depends on every single case if the residence permit can be obtained in 90 days or not," said Heidenhain.
The Citizenship and Migration Board issued 307,996 alien passports from 1996 to 2000, but a person can also have a Russian or any other passport with a temporary residence permit to reside in Estonia legally.
As for people with temporary residence permits, 64 percent of them were non-citizens, and 32 percent were Russian citizens as of December 2000.
According to the Citizenship and Migration Board, Estonia has issued only four asylum permits to foreigners ever, to two Afghans and two Algerians.
Fifty-one foreigners applied for asylum from 1997 to 2001, most of them in 1998 and 1999. Fifteen were from Iraq. The Estonian Parliament passed the law on refugees in 1997, and therefore no records of previous years were kept, according to the Citizenship and Migration Board.

redpajama_set_name: RedPajamaCommonCrawl


text:
Chandler Gymnasium
The home of the Ephs volleyball team is John Wesley Chandler Gymnasium, named after the 12th president of Williams. Chandler Athletic Center also houses coaches' offices for most of the Eph varsity teams.
Located in the heart of the Williams campus and the center of Williamstown, the John Wesley Chandler Athletic Center was recognized in 1991 as a Facility of Merit by Athletic Business magazine for the way it connects existing Williams athletic facilities and adds to the business district in "the Village Beautiful."
The gymnasium in Chandler can accommodate up to 1,600 people.


Welcome to the 2019 Scouting Friends and Family giving site! This is a tool to help scouting units raise money to support resources provided to them through Northern Star Council. Money goes to the Northern Star Council to support capital improvements at camps used by Troop 62.
To make this all possible, we need support from you. Our goal given to us by the Northern Star Council is $4,500.
Deadline to collect the money is May 15th.
Ideal people to ask for a contribution are; parents, grandparents, uncles and aunts, neighbors, friends, past Boys Scouts-especially Eagle Scouts you know etc.
Checks can be written out to Friends of Scouting. Bring money you collect to Monday Scout meetings.
Thank you for your help!! You approaching or calling them in uniform greatly improves your success.
Any questions, call or email Wade Hermes at 612-868-7322.


text:
Q: Hosting two different django project in the same droplet with different subdomains (NGINX, Gunicorn, ubuntu) As the title says I want to host two different django project in the same droplet (NGINX, Gunicorn, ubuntu) with different subdomains. One will be our main site example.com. which is up and running and working perfectly. We want to host the staging site staging.example.com in the same droplet.
We have created new sockets and service files for the staging site and activated and enabled them but the issue is nginx still points to the files in main domain directory rather than the staging directory and hence we get this error below even though these domains have been added in the allowed hosts of settings.py of the staging site

DisallowedHost at /
Invalid HTTP_HOST header: 'staging.example.com'. You may need to add 'staging.example.com' to ALLOWED_HOSTS

Here is our staging.guinicorn.service file
  [Unit]
Description=staging.gunicorn daemon
Requires=staging.gunicorn.socket
After=network.target

[Service]
User=admin
Group=www-data
WorkingDirectory=/home/admin/example1staging
ExecStart=/home/admin/example1staging/venv/bin/gunicorn --access-logfile - --workers 3 --bind unix:/run/staging.gunicorn.sock djangoproject.wsgi:application

[Install]
WantedBy=multi-user.target

Here is our staging.guicorn.socket file
[Unit]
Description=staging.gunicorn socket

[Socket]
ListenStream=/run/staging.gunicorn.sock

[Install]
WantedBy=sockets.target

Lastly here is our nginx config
server {
    listen 80;
    listen [::]:80;
    server_name example.com www.example.com;
    return 302 https://$server_name$request_uri;
}

server {
    # SSL configuration

    listen 443 ssl http2;
    listen [::]:443 ssl http2;
    ssl_certificate         /etc/ssl/cert.pem;
    ssl_certificate_key     /etc/ssl/key.pem;
    ssl_client_certificate /etc/ssl/cloudflare.crt;
    ssl_verify_client on;

    root /var/www/html;
    index index.html index.htm index.nginx-debian.html;

    location = /favicon.ico { access_log off; log_not_found off; }
    location /static/ {
        root /home/admin/example1;
    }

    location / {
        include proxy_params;
        proxy_pass http://unix:/run/gunicorn.sock;
    }
}

server {
    listen 80;
    listen [::]:80;
    server_name staging.example.com www.staging.example.com;
    return 302 https://$server_name$request_uri;
}

server {
    # SSL configuration

    listen 443 ssl http2;
    listen [::]:443 ssl http2;
    ssl_certificate         /etc/ssl/cert.pem;
    ssl_certificate_key     /etc/ssl/key.pem;
    ssl_client_certificate /etc/ssl/cloudflare.crt;
    ssl_verify_client on;

    root /var/www/html;
    index index.html index.htm index.nginx-debian.html;

    location = /favicon.ico { access_log off; log_not_found off; }
    location /static/ {
        root /home/admin/example1staging;
    }

    location / {
        include proxy_params;
        proxy_pass http://unix:/run/staging.gunicorn.sock;
    }
}

Some help here would be extremely welcome.

redpajama_set_name: RedPajamaStackExchange


text:
Non-Stop Capital XTRA 1am - 6am
Toast Koffee Download 'Toast' on iTunes
Caitlyn Jenner reveals shock details of OJ Simpson trial: "There's no way Robert Kardashian didn't know"
6 December 2019, 11:14 | Updated: 6 October 2020, 08:51
Caitlyn Jenner opened up about the "trial of the century" where OJ Simpson was accused of murdering his wife Nicole. Picture: Getty
Caitlyn opened up Kardashian's role in OJ Simpson's infamous trial over the murder of his wife Nicole Brown.
Since being in the jungle, I'm A Celeb star Caitlyn Jenner has spilled the beans on plenty of Kardashian-Jenner gossip - and her latest may be the juiciest yet.
Caitlyn Jenner labelled "unfair" after saying Khloe Kardashian hasn't spoken to her since her transition
The transgender reality star, 70, opened up her involvement in the infamous OJ Simpson trial involving the murder of Simpson's wife Nicole Brown, calling the trial a "joke".
Caitlyn was married to Kris Jenner at the time, while Kris' ex-husband Robert Kardashian helped to defend Simpson, which eventually led to him being acquitted.
Robert Kardashian was OJ Simpson's attorney during the infamous murder trial. Picture: Getty
Speaking to her campmates, Caitlyn revealed, "I saw Nicole two days before she was murdered. It was Kris' best friend, we were right in the middle of it. [Kris'] ex-husband Robert - OJ was the best man at their wedding."
Caitlyn explained that she and Kris always thought OJ was guilty. "It was a bad time for everybody, very difficult," she continued. "We knew what happened and this trial was a joke and when the verdict came down Kris just turned around to me and goes: "We should have listened to Nicole from the beginning, she was right.""
"That night the verdict came in Kourtney and Kimberly [Kardashian] were in school and obviously they loved their father - and they should - and they'd been following this for a year and a half."
Cailtyn, then Bruce, was married to Robert Kardashian's ex-wife Kris Jenner - who was also Nicole's best friend - from 1991 to 2015. Picture: Getty
"And when they walked in the door, I think it was Kourtney who said: "Well I told you he didn't do it."" After this, Caitlyn said she banned the family from mentioning OJ's name in their house again.
When her campmate Jacquline Jossa asked whether Robert knew the truth about the murder, Caitlyn replied, "I mean, there's just no way he didn't know."
Fellow campmate Kate Garraway asked whether Cailtyn liked OJ, the former Olympic athlete shook her head. "No. Too big an ego for me. We went on some vacations together with OJ and Nicole and the kids.
"I liked Nicole and she sure didn't deserve what she got."
At the time of the trial, Caitlyn - then Bruce - had been married to Kris Jenner for three years following her divorce from Robert. Picture: Getty
Simpson was eventually acquitted on two counts of murder. However, in 1997, the jury found Simpson responsible for both deaths and the families were awarded damages of $33.5 million.
> Download Our Free App For All The Latest Music News!


Below is live coverage of the How to Turn Your Web Analytics Into a Money-Making Machine from the SES Chicago 2009 (official SES Chicago Site) conference.
This coverage is provided by Brian Ussery - Beu Blog.
You tagged your website with analytics. You may even login to check your stats or get them emailed to you. What does it all mean? How do you find anything useful in the endless amounts of data provided? How do you turn those reports into insight and action? In this session, each panelist will provide you with 3 solid tips to make money from your web analytics and answer questions about everything you've wanted to know about web analytics but were afraid to ask.
"The key to making web analytics work is having a process."
You can't make money with web analytics by just looking at reports.
Improve conversion rates (the number of people who take action you wanted them to take divided by number of people.) But…. this isn't the best metric as not all are qualified.
Each one has different conversion points.
Use google segmentation factors to see persona criteria.
don't focus on conversion but ROI. What about the rest of the process?
1. Optimize holistically - different creative same landing pages via utm content in GA.
After, existential KPIs how to optimize the other 98%?
Up next Jim Sterne from eMetrics and WAA.
most optimial basket "Amazon 1 Click"
focus on specific process ie "cart process"
First question, where are the problems? How can we fix?
user testing and survey... Analytics only shows where the problem maybe but not the "problem".
Time on site, little value.
"If you want to increase conversions stop advertising!"
First question is about assists with Google Analytics such as view through conversions in the content network?
Mui says Analytics is an island at Google in terms of sharing data.
What impact will personalization have?
Sterne says major issue because results are different. Maybe now we need a service to create different personas.
Eisenberg says Google can personalize per person this is a challenge.
Question using analytics for SEO.
Mui says Google doesn't comment on future issues but said that 2010 could be the year of SEO.
adds that Insights for search ad planner great demo tools.


text:
r/PhilosophyofReligion
https://reddit.com/r/PhilosophyofReligion/ launch
r/AcademicPhilosophy
This reddit is intended for academic philosophers - (graduate) students, teachers, and researchers. Encouraged submissions: Open access articles of merit and substance, including from the popular press, that directly engage with a philosophical issue or concern the philosophical academic community. Links to teaching resources also appreciated.
https://reddit.com/r/AcademicPhilosophy/ launch
r/PhilosophyofScience
https://reddit.com/r/PhilosophyofScience/ launch
r/DebateReligion
A place to discuss and debate religion.
https://reddit.com/r/DebateReligion/ launch
r/askphilosophy
/r/askphilosophy aims to provide serious, well-researched answers to philosophical questions.
https://reddit.com/r/askphilosophy/ launch
r/DebateAChristian
https://reddit.com/r/DebateAChristian/ launch
r/theology
**Theology** articles, news, essays, & perspectives.
https://reddit.com/r/theology/ launch
r/ReasonableFaith
5k subs
Our Mission: Reasonable Faith aims to provide in the public arena an intelligent, articulate, and uncompromising yet gracious Christian perspective on the most important issues concerning the truth of the Christian faith today.
https://reddit.com/r/ReasonableFaith/ launch
r/religion
https://reddit.com/r/religion/ launch
r/DebateAnAtheist
A very active subreddit to debate and pose arguments to atheists, people who lack a belief in any of the gods that other people have proposed exist. Post your best arguments for the supernatural, discuss why your faith is true, and tell us how your reasoning led you to a belief in the supernatural. r/DebateAnAtheist is dedicated to discovering what is true and real and useful and using debate to ascertain beliefs we can be confident about. Remember to upvote comments with solid effort.
https://reddit.com/r/DebateAnAtheist/ launch
r/badphilosophy
/r/badphilosophy is currently open. Don't make me close it again. Please use the Old Reddit design, linked in the top left corner.
https://reddit.com/r/badphilosophy/ launch
r/TrueAtheism
A subreddit dedicated to insightful posts and thoughtful, balanced discussion about atheism specifically and related topics concerning irreligion and religion generally.
https://reddit.com/r/TrueAtheism/ launch
r/PoliticalPhilosophy
A subreddit for the discussion of political philosophies and theories from the likes of Aristotle, Machiavelli, Locke, Hume, Kant, Burke, Thoreau, Nietzsche, Rawls, and Arendt. Or for just talking, seriously, about politics, i.e. respectable in-depth discussion, don't vote someone down simply because you disagree. Treat this subreddit as though the people that you are talking with are gathered in the same room with you.
https://reddit.com/r/PoliticalPhilosophy/ launch
r/ChristianApologetics
A place for Christians and other interested parties to come together to discuss rational arguments for the faith. For more detail on our purpose, rules, and related community policies, [visit our FAQ](http://www.reddit.com/r/ChristianApologetics/wiki/faq).
https://reddit.com/r/ChristianApologetics/ launch
r/philosophy
14m subs
https://reddit.com/r/philosophy/ launch
r/HistoryofIdeas
Welcome to the subreddit for the study of the history of ideas, including the histories of philosophy, of literature and the arts, of the natural and social sciences, of religion, and of political thought!
https://reddit.com/r/HistoryofIdeas/ launch
r/RadicalChristianity
Welcome! ----- /r/radicalChristianity has emerged as a community of people discussing the intersection of philosophy, theology, critical theory, and revolutionary politics. We are interested in re-investing Christianity with its transgressive elements, and as such we are openly against oppressive discourses (sexism, racism, ageism, homophobia, transphobia, xenophobia). **We invite you to participate!** Please [message us](http://www.reddit.com/message/compose?to=%2Fr%2FRadicalChristianity).
https://reddit.com/r/RadicalChristianity/ launch
r/AcademicBiblical
A subreddit for discussion of early Judaism and Christianity — with a focus on Biblical texts and related literature (1 Enoch, the Dead Sea Scrolls, and so on) — in a scholarly context. Relevant topics might include general exegetical issues, ancient languages and translation, the study of the historical Jesus, textual criticism, reception history of early Jewish/Christian literature, etc.
https://reddit.com/r/AcademicBiblical/ launch
r/Christianity
/r/Christianity is a subreddit to discuss Christianity and aspects of Christian life. All are welcome to participate.
https://reddit.com/r/Christianity/ launch
r/Buddhism
A reddit for all kinds of Buddhist teachings
https://reddit.com/r/Buddhism/ launch
r/TrueChristian
A subreddit for Christians of all sorts. We exist to provide a safe haven for all followers of Jesus Christ to discuss God, Jesus, the Bible, and information relative to our beliefs, and to provide non-believers a place to ask questions about Christianity as explained in the scriptures, without fear of mockery or debasement. To post suggestions or ideas for the sub, please go to /r/TrueChristianMeta.
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r/ELINT
Explain it Like I'm Not a Theologian™! We don't all have the time - or interest - to engage in the systematic and rational study of any or all religions, their meanings, claims, or influences: so ask someone who does! Religion Debate Theology Apologetics Faith Beliefs Worldviews Gospel Bible Philosophy
https://reddit.com/r/ELINT/ launch
r/zen
https://reddit.com/r/zen/ launch
r/CriticalTheory
Critical theory is a school of thought that stresses the examination and the critique of society and culture by applying knowledge from the social sciences and the humanities.
https://reddit.com/r/CriticalTheory/ launch
r/Catholicism
/r/Catholicism is a place to present new developments in the world of Catholicism, discuss theological teachings of the Catholic Church, provide an avenue for reasonable dialogue amongst people of all beliefs, and grow in our own spirituality. Catholic Christianity offers the world the fullness of the Christian Faith.
https://reddit.com/r/Catholicism/ launch
r/OrthodoxChristianity
A subreddit dedicated to discussion of Eastern Christianity.
https://reddit.com/r/OrthodoxChristianity/ launch
r/Reformed
/r/Reformed exists to be a place where believers can come together in unity by the bonds of the Gospel to exhort one another, spur one another on intellectually in reformed theology, discuss doctrine and even non-essential doctrinal differences.
https://reddit.com/r/Reformed/ launch
r/AskReligion
A subreddit for all your religion questions.
https://reddit.com/r/AskReligion/ launch
r/TheAgora
https://reddit.com/r/TheAgora/ launch
r/spirituality
https://reddit.com/r/spirituality/ launch
r/psychology
A Reddit community for sharing and discussing science-based psychological material.
https://reddit.com/r/psychology/ launch


Hybrid metal halide perovskites have emerged as an important new class of materials for photovoltaics. Their integration in tandem with other photovoltaic technologies such as silicon cells is highly desirable, allowing low-cost cells with efficiencies in excess of the Shockley-Queisser single-junction limit. Optimized photocurrent matching between top and bottom cells requires careful control over band-gap energy of the perovskite for which the development of stable, compositionally tuneable perovskites will be essential. In this project, we will explore emerging hybrid perovskites with a focus on developing our fundamental understanding of how structural properties in these relatively "soft" semiconductors are related to their thermodynamic stability and optoelectronic properties. The project will be based around a multi-facetted experimental investigation, involving structural probes e.g. through X-ray diffraction, and transient charge-carrier probes using THz conductivity and photoluminescence spectroscopy. Using these measurements, we will establish links between structural and electronic properties, which will allow us to reveal e.g. the mechanisms behind light- and electric-field-induced changes in these materials, and the causes of miscibility gaps. We will exploit the resulting insight to develop new perovskite compositions and material processing protocols to create thin-film perovskite absorbers with long-term stability for tandem solar cells.


Who will be resurrected first, and how will bodies be reconstructed? Where will the dead arise, and what will happen to those who are alive at the time?
Learning & Values » Essentials of the Jewish Religion » Moshiach 101 » The Messianic Era » What Will Happen When Moshiach Comes?
While not all souls have an equal share in Gan Eden; in rare instances, certain souls do not earn any share at all. The "World to Come," however, is different. Every Jewish soul that ever lived will be resurrected.
Ultimately, the reward for our efforts will not be limited to that which we have directly earned—that which is humanly possible to achieve. During the Resurrection Era, we will be treated to a reward which can only be viewed as a gift from Above.
Kabbalah explains which aspects of a person return at the Resurrection of the Dead.
What is the Jewish belief in the Resurrection of the Dead? What will actually happen and what is the purpose of this supernatural phenomenon?
We believe that following the coming of Moshiach we will all be reunited with all the departed souls of our loved ones. Why is the resurrection of the dead such a fundamental belief in Judaism?
Chapter 3: The World to Come: Why a Bodily Resurrection?
Chapter 5: Who Will Rise?
Chapter 6: When Will the Resurrection Take Place?


Why Should You Attend UWA?
Very few universities can still offer the top-quality academic programs you'll find at UWA. Take your pick from associate, bachelor's and master's degree programs. Study business, education, liberal arts, nursing or natural sciences and mathematics. With more than 60 undergraduate programs and 20 graduate programs, there's something for everyone at UWA. Choose the program that's right for you!
Our faculty is outstanding, too. They publish in prestigious peer-reviewed journals, lead important research projects, chair national associations, spearhead outreach and service projects and win awards for excellence in their professions. But most of all they simply love to teach. And isn't that what the best teachers are all about?
Where else can you find classes that offer an 15:1 student-to-teacher ratio? With an average of 30 students in every class, you'll never get lost in the crowd here.
And did we mention, only full professors teach classes. You won't find a graduate assistant leading a lecture at UWA.
You know there's more to college than classes. We know it, too. That's why you'll find everything you need to enjoy a full life right here on the UWA campus: from comfortable residence halls with all the modern conveniences to fraternities, sororities, intramural sports, entertainment, religious organizations, student government organizations and so much more. Check it out.
In fact, we're so big on student activities and intramural sports we've devoted a full-time staff to make sure there's always something exciting going on at UWA.
Are you wired? Wi-Fi access is available everywhere on campus to keep you connected to friends, family, classmates and faculty.
How's this for cool? Our beautiful 600-acre campus has nature trails and a 54-acre lake that's stocked for fishing. It's also recognized as being one of the safest college campuses in the nation.
Want to play? You can do it all at UWA — baseball, basketball, cross country, football, softball, tennis, volleyball and rodeo! Varsity athletics rule at UWA. Come on out and have some fun.
Can you really afford a top education like this? Tuition for UWA is lower than many other state universities in the state. We also offer a full range of grants, scholarships and loans to help you meet your education goals. With values like this, can you afford not to attend UWA?


FRANKFORT, Ky. (March 5, 2018) – First Lady Glenna Bevin today announced the winning entry, as well as the second- and third-place finishers, in her annual Kentucky Derby Poster Contest.
This year's first-place winner, Ashley McHone, is an 11th grader at Shelby County Big Picture Learning Academy. McHone will receive a $500 scholarship from the First Lady's foundation, #WeAreKY! Inc., and her poster will be on permanent display at the State Capitol. A copy of her artwork will also be presented to the president of the Kentucky Derby Festival, as the Governor's traditional gift.
McHone's poster will be available for purchase in April in the Governor's office (700 Capital Avenue, Room 100, Frankfort) and on the First Lady's website (http://firstlady.ky.gov).
Mallery Marshall, a 9th grader at Pleasure Ridge Park High School (Jefferson County), had the second-place entry and will receive a $300 scholarship from the First Lady's foundation. Jessica Lee, a 12th grader at St. Henry District High School (Boone County), had the third-place entry and will receive a $200 scholarship.
To download images of the winning poster, as well as the second- and third-place entries, please click here.


Legends of To-Meow-Meow (S04E08) is the eighth episode of season four of "DC's Legends of ... More Legends of To-Meow-Meow (S04E08) is the eighth episode of season four of "DC's Legends of Tomorrow" released on Mon Dec 10, 2018. Over 16,170 TV Time users rated it a 9.3/10 with their favorite characters being Matt Ryan as John Constantine, Tala Ashe as Zari Tomaz and Maisie Richardson-Sellers as Amaya Jiwe.
Who else agrees that this has been the best episode of Legends this season?
"What is this?" The team we never knew we needed.
LEGENDS OF TOMORROW IS DOING WHAT OTHERS TV SERIES ARE TOO AFRAID TO DO.
A gay, interracial, kiss saved the time line; a beautiful, developed, healthy, shaped relationship between two women are the center of the show; male characters who are willing to take down toxic masculinity; the first Muslim superhero (MY GIRL) who so naturally flirts with another women. I was quite sad that they weren't in the crossover just because it brings more people to watch it but after this episode I realized that they don't need it: yes, it's a crazy show, with a lot of fantasy and imagination, but they're funny as hell and were able to make fun of the annual crossover, in the best way possible, and created their own magical event. That's how creativity works. LoT deserves so much better.
Me: Why aren't the Legends in the crossover? They better have a good reason!
- Legends? It'z Barry, Oliver and Kara we need your help!
- I'm sorry, the old Legends of Tomorrow can't come to the phone right now.
- Oh, 'cause Sarah's dead!
As a cat, Zari is still the best!


Ensuring composure no matter the driving circumstances! Subaru prioritized practicality, efficiency, and style by including: leather upholstery, heated front and rear seats, and a blind spot monitoring system. Under the hood you'll find a 4 cylinder engine with more than 170 horsepower, and all wheel drive keeps this model firmly attached to the road surface.


12. Chaplet of the Holy Spouses, Mary and Joseph.
Protector of the Church, pray for us.
as we venerate him as our protector on earth.
You who live and and reign forever and ever. R. Amen.
To you, O Blessed Joseph, we come in our trials, and having asked the help of your most holy spouse, we confidently ask your patronage also. Through that sacred bond of charity which united you to the Immaculate Virgin Mother of God and through the fatherly love with which you embraced the Child Jesus, we humbly beg you to look graciously upon the beloved inheritance which Jesus Christ purchased by his blood, and to aid us in our necessities with your power and strength.
O most provident guardian of the Holy Family, defend the chosen children of Jesus Christ. Most beloved father, dispel the evil of falsehood and sin. Our most mighty protector, graciously assist us from heaven in our struggle with the powers of darkness. And just as you once saved the Child Jesus from mortal danger, so now defend God's Holy Church from the snares of her enemies and from all adversity. Shield each one of us by your constant protection, so that, supported by your example and your help, we may be able to live a virtuous life, to die a holy death, and to obtain eternal happiness in heaven. Amen.
Saint Joseph, father and guardian of virgins, to whose faithful keeping Christ Jesus, innocence itself, and Mary, the virgin of virgins was entrusted, I pray and beseech you by that twofold and most precious charge, to save me from all uncleanness, to keep my mind untainted, my heart and body pure in my vocation; and to help me always to serve Jesus and Mary in perfect purity. Amen.
O Glorious Saint Joseph, I choose you today for my special patron in life and at the hour of my death. Preserve and increase in me the spirit of prayer and fervor in the service of God. Remove far from me every kind of sin; obtain for me that my death may not come upon me unawares, but that I may have time to confess my sins sacramentally and to bewail them with a most perfect understanding and a most sincere and perfect contrition, in order that I may breathe forth my soul into the hands of Jesus and Mary. Amen.
Saint Joseph, you are the chaste and loving spouse of the Virgin Mary, the foster father of Jesus, the protector and provider of the Holy Family and of all families. We have complete confidence in your loving care for new life and in your fidelity to the family. We commend our efforts to your prayers and protection. Help us always to defend the gift of human life that it may grow to the abundance of eternal life promised and bestowed on us by your son, our brother, Jesus Christ. Amen.
Saint Joseph, protect our home. Pour forth from heaven blessings on our family. Remain in our midst. Help us to live in love and harmony, in peace and joy. May the wholesome fear of God strengthen us that virtue may adorn what we do and our way may lead to heaven.
To you this day I give the key to our dwelling place. Lock out all things that could do us harm. Lock my home and my loved ones with me in the hearts of Jesus and Mary. This I beg of you, that our days may be like your days in the holy home at Nazareth. Amen.
O Saint Joseph, you witnessed the miracle of birth, seeing the infant Jesus born of your most holy spouse, the Virgin Mary. With wonder and awe, you took into your arms the Savior. With gratitude that only a parent can know, you glorified God for the birth of his Son, entrusted to your fatherly care.
Like you, Saint Joseph, I too give praise and glory to God for the birth of my child. This child's life is such a miraculous testimony of God's loving presence. My heart is filled with grateful joy. Join me dear Saint Joseph, in offering thanks to God for the gift of my child.
What great trust and confidence God placed in you, Saint Joseph, by entrusting his only Son into your fatherly care. This inspires me to entrust the spiritual care and protection of my newborn child into your competent and loving hands. Teach, guide, and support me to fulfill well my awesome vocation to be a worthy parent to this child. Amen.
O Glorious Saint Joseph, after the Blessed Virgin, you were the first to hold in your arms the Redeemer. Be our exemplar in our ministry, which like your own, is a ministry of intimate relationship with the Divine Word. May you teach us; may you assist us; may you make us worthy members of the Holy Family. Amen.
V. The angel of the Lord appeared to Joseph in a dream.
V. Pray for us, O virgin father of Jesus.
we may live totally dedicated to the interests of the Savior. Amen.
one God, for ever and ever. R. Amen.
(Mt 1:18) Now this is how the birth of Jesus Christ came about. When his mother Mary was betrothed to Joseph, but before they lived together, she was found with child through the holy Spirit.
(Mt 1:19-21) Joseph her husband, since he was a righteous man, yet unwilling to expose her to shame, decided to divorce her quietly. Such was his intention when, behold, the angel of the Lord appeared to him in a dream and said, "Joseph, son of David, do not be afraid to take Mary your wife into your home. For it is through the holy Spirit that this child has been conceived in her. She will bear a son and you are to name him Jesus, because he will save his people from their sins."
(Mt 1:22-25) All this took place to fulfill what the Lord had said through the prophet: "Behold, the virgin shall be with child and bear a son, and they shall name him Emmanuel," which means "God is with us." When Joseph awoke, he did as the angel of the Lord had commanded him and took his wife into his home. He had no relations with her until she bore a son, and he named him Jesus.
(Mt 2:13-15) When they had departed, behold, the angel of the Lord appeared to Joseph in a dream and said, "Rise, take the child and his mother, flee to Egypt, and stay there until I tell you. Herod is going to search for the child to destroy him." Joseph rose and took the child and his mother by night and departed for Egypt. He stayed there until the death of Herod, that what the Lord had said through the prophet might be fulfilled, "Out of Egypt I called my son."
(Mt 2:19-23) When Herod had died, behold, the angel of the Lord appeared in a dream to Joseph in Egypt and said, "Rise, take the child and his mother and go to the land of Israel, for those who sought the child's life are dead." He rose, took the child and his mother, and went to the land of Israel. But when he heard that Archelaus was ruling over Judea in place of his father Herod, he was afraid to go back there. And because he had been warned in a dream, he departed for the region of Galilee. He went and dwelt in a town called Nazareth, so that what had been spoken through the prophets might be fulfilled, "He shall be called a Nazorean."
(Lk 2:51-52)He went down with them and came to Nazareth, and was obedient to them; and his mother kept all these things in her heart. And Jesus advanced in wisdom and age and favor before God and man.
Mediation: Chaste Lover of Mary, how overwhelmed you were when you thought that you would have to end your betrothal to her. But when the angel of God came to you in a dream, you were filled with awe to realize that Mary would be your wife, and you would be the guardian of the Messiah.
and develop an absolute trust in God's goodness.
Mediation: Faithful guardian of Jesus, what a failure you thought you were when you could only provide a stable for the birth of the Holy Child. And then what a wonder it was when shepherds came to tell of angel choirs, and wise men came to adore the King of Kings.
with absolute love and respect.
Mediation: Tender-hearted Joseph, you too felt pain when the blood of Jesus was first shed at His circumcision. Yet how proud you were to be the one privileged to give the name Jesus, Savior, to the very Son of God.
may be written in our hearts forever.
Mediation: Joseph, loving husband, how bewildered you were when Simeon spoke the words of warning that the hearts of Jesus and Mary would be pierced with sorrows. Yet his prediction that this would lead to the salvation of innumerable souls filled you with consolation.
can become the pathway to salvation and eternal life.
Mediation: Courageous protector of the Holy Family, how terrified you were when you had to make the sudden flight with Jesus and Mary to escape the treachery of King Herod and the cruelty of his soldiers. But when you reached Egypt, what satisfaction you had to know that the Savior of the world had come to replace the pagan idols.
we may be entirely devoted to the service of Jesus and Mary.
Mediation: Ever-obedient Joseph, you trustingly returned to Nazareth at God's command, in spite of your fear that King Herod's son might still be a threat to Jesus' life. Then what fatherly pride you had in seeing Jesus grow in wisdom and grace before God and men under your care.
living safely with Jesus in our hearts.
Mediation: Dependable father and husband, how frantic you and Mary were when, through no fault of yours, you searched for three days to find Jesus. What incredible relief was yours when you found Him safe in the Temple of God.
never to lose Jesus through the fault of our own sins.
dying safely in the arms of Jesus and Mary.
to give us sinners new life.
the favor we ask . . . (Pause) . . .
beg of Jesus mercy for us.
those who pray, those who weep.
may the love of Jesus answer our call of confident hope. Amen.
Ant. And Jesus himself, when he began his work, was about thirty years old being, as was supposed, the son of Joseph.
V. Pray for us, holy Joseph.
you entrusted our Savior to the care of Saint Joseph.
one God, forever and ever. R. Amen.
and to you, guardian of the Redeemer.
with whom you formed a family, Jesus.
in the mystery of the Word Incarnate.
and may walk more joyfully in the way of love.
(Lk 1:28-35, 38) In the sixth month, the angel Gabriel was sent from God to a town of Galilee called Nazareth, to a virgin betrothed to a man named Joseph, of the house of David, and the virgin's name was Mary. And coming to her, he said, "Hail, full of grace! The Lord is with you." But she was greatly troubled at what was said and pondered what sort of greeting this might be. Then the angel said to her, "Do not be afraid, Mary, for you have found favor with God. Behold, you will conceive in your womb and bear a son, and you shall name him Jesus. He will be great and will be called Son of the Most High, and the Lord God will give him the throne of David his father, and he will rule over the house of Jacob forever, and of his kingdom there will be no end." But Mary said to the angel, "How can this be, since I have no relations with a man?" And the angel said to her in reply, "The holy Spirit will come upon you, and the power of the Most High will overshadow you. Therefore the child to be born will be called holy, the Son of God. Mary said, "Behold, I am the handmaid of the Lord. May it be done to me according to your word." Then the angel departed from her.
(Lk 2:3-7,15-16) Joseph too went up from Galilee from the town of Nazareth to Judea, to the city of David that is called Bethlehem, because he was of the house and family of David, to be enrolled with Mary, his betrothed, who was with child. While they were there, the time came for her to have her child and she gave birth to her firstborn son. She wrapped him in swaddling clothes and laid him in a manger, because there was no room for them in the inn.
When the angels went away from them to heaven, the shepherds said to one another, "Let us go, then, to Bethlehem to see this thing that has taken place, which the Lord has made known to us." So they went in haste and found Mary and Joseph, and the infant lying in the manger.
(Lk 2:21) When eight days were completed for his circumcision, he was named Jesus, the name given him by the angel before he was conceived in the womb.
(Lk 2:22-40) When the days were completed for purification according to the law of Moses, they took him up to Jerusalem to present him to the Lord, just as it is written in the law of the Lord, "Every male that opens the womb shall be consecrated to the Lord," and to offer the sacrifice of "a pair of turtledoves or two young pigeons," in accordance with the dictate in the law of the Lord. Now there was a man in Jerusalem whose name was Simeon. This man was righteous and devout, awaiting the consolation of Israel, and the holy Spirit was upon him. It had been revealed to him by the holy Spirit that he should not see death before he had seen the Messiah of the Lord. He came in the Spirit into the temple; and when the parents brought in the child Jesus to perform the custom of the law in regard to him, he took him into his arms and blessed God. He came in the Spirit into the temple; and when the parents brought in the child Jesus to perform the custom of the law in regard to him, he took him into his arms and blessed God, saying: "Now, Master, you may let your servant go in peace, according to your word, for my eyes have seen your salvation, which you prepared in sight of all the peoples, a light for revelation to the Gentiles, and glory for your people Israel." The child's father and mother were amazed at what was said about him; He said to Mary his mother, "Behold, this child is destined for the fall and rise of many in Israel, and to be a sign that will be contradicted and you yourself a sword will pierce so that the thoughts of many hearts may be revealed." There was also a prophetess, Anna, the daughter of Phanuel, of the tribe of Asher. She was advanced in years, having lived seven years with her husband after her marriage, and then as a widow until she was eighty-four. She never left the temple, but worshiped night and day with fasting and prayer. And coming forward at that very time, she gave thanks to God and spoke about the child to all who were awaiting the redemption of Jerusalem. When they had fulfilled all the prescriptions of the law of the Lord, they returned to Galilee, to their own town of Nazareth. The child grew and became strong, filled with wisdom; and the favor of God was upon him.
(Lk 2:41-50) Each year the parents of Jesus went to Jerusalem for the feast of Passover, and when he was twelve years old, they went up according to festival custom. After they had completed its days, as they were returning, the boy Jesus remained behind in Jerusalem, but his parents did not know it. Thinking that he was in the caravan, they journeyed for a day and looked for him among their relatives and acquaintances, but not finding him, they returned to Jerusalem to look for him. After three days they found him in the temple, sitting in the midst of the teachers, listening to them and asking them questions, and all who heard him were astounded at his understanding and his answers. When his parents saw him, they were astonished, and his mother said to him, "Son, why have you done this to us? Your father and I have been looking for you with great anxiety." And he said to them, "Why were you looking for me? Did you not know that I must be in my Father's house?" But they did not understand what he said to them.
(Lk 2:51-52) Jesus went down with them and came to Nazareth, and was obedient to them; and his mother kept all these things in her heart. And Jesus advanced in wisdom and age and favor before God and man.


text:
Q: How to create index table for order by in DynamoDB AWS I want to store the information of user and their total_score.
Each user has a facebook_id and it will be the primary key.
I designed the table and index like that:
Table name: UserDataTest
Primary partition key:  facebook_id (String)

Now I want to get top 50 user follow by total_ranking.
I wrote the query params like that:
var params = {
    TableName : "UserDataTest",
    ProjectionExpression:"facebook_id, facebook_name, #lev, total_star, total_crown, total_ranking, isVip",
    IndexName: "facebook_id-total_ranking-index",
    ExpressionAttributeNames: {
      "#lev" : "level"
    }
    ScanIndexForward: false,
    Limit: 50
};

But i could not get the data that I need. Can you give me a solution for this? Any idea for rewrite the query or redesign the table?
Thanks


text:
Just Say Yes
A Commentary By Susan Estrich
in Political Commentary
Parties Afraid to Face Population Explosion By Froma Harrop
Obama, Clinton, Biden and McCain By Debra J. Saunders
39% See Michelle Obama as Very Liberal
There is a very easy way for Barack Obama's team to avoid floor fights at the Democratic National Convention.
Just say yes.
Every four years, whoever is running the convention uses polls and focus groups to find out what would be the best and worst possible scenarios for a convention. And every four years, the results are the same. The press wants fights. They want contention, minority reports and roll call votes.
This is not what would-be voters want. They want peace. They have this idea, not entirely without merit, that if you can't run your own convention -- where you control a majority of delegates -- you can't run the country.
The prototype of a bad convention is 1968, with the Chicago police attacking demonstrators, who looked an awful lot like college students, outside the hall, and the scene only slightly friendlier inside. But the Democratic Convention in 1972 wasn't much better, with George McGovern delivering his eloquent "Come Home, America" speech at 3 a.m., long after most Americans had not only come home, but gone to bed.
Get the timing right. Accept the nomination in prime time. No one wins the fights except the loser. That was certainly the lesson in 1980, when the Carter campaign, collecting the signatures for minority reports, decided -- for reasons I'm not sure I understand to this day, and I was there -- that whatever the Kennedy forces proposed in the Platform, Rules and Credentials committees, they would oppose. Fine with us. We turned platform into the 51st primary. You want to explain to your labor delegates why they're voting against health insurance for all; to women why they're voting against reproductive freedom; to everyone why they're voting against a plank to provide food and housing assistance for needy children (I wrote that one myself)…
By the time we headed into the convention, I had perfected the trick of having committee members sign their names on blank pieces of paper over and over, which I could then staple to cover sheets with the "minority reports" of my choice, giving me something like 44 of them (half an hour of debate per side, roll call votes, the whole nine yards) to start trading away for a speech for Sen. Kennedy, not to mention some fun victories on the floor. Fun for whom? Not Jimmy Carter.
Democrats haven't made that particular mistake again, in part because the veterans of those past failures have generally been in charge, one way or another, ever since, and most of us have vowed to keep the fights to a minimum and the speeches in prime time. What you put in the platform doesn't matter; it's what you don't. Whom you seat doesn't matter; it's whom you don't. Remember the Republican Convention in 1992, where conservative Christians tried to keep Lincoln out of the platform and Ronald Reagan emerged as the voice of moderation? I called all my friends from Houston, where the Republicans were meeting, to tell them the good news. Good for Democrats.
The lesson in all of this for Barack Obama is very simple. Just say yes. Assuming the confidence his people are insisting they feel is justified, and that he really is on the verge of locking this up, the only thing he should really be thinking about is his vice presidential selection. Nothing else matters, except not giving Democrats (some of whom are ready to fight if they have an excuse) the excuse.
Sorry, but this is not about principle. It's about politics. It's about not creating issues you don't need. If Michigan and Florida really won't save Hillary, let her have them. They lost the influence they would have had on the process had their votes counted in the first instance. Be gracious. Graciousness becomes a winner. Scrappiness is what you expect from someone who's still fighting to win. Which one is Obama?
COPYRIGHT 2008 CREATORS SYNDICATE INC.
Views expressed in this column are those of the author, not those of Rasmussen Reports.
See Other Commentary by Susan Estrich
See Other Political Commentary


text:
Tulo 'pumped up' to start spring with HR vs. Jays
143dColey Harvey
Yankees' Troy Tulowitzki 'a little pumped up' after homering against Blue Jays
Coley HarveyESPN Staff Writer
Previously covered Florida State for Orlando Sentinel and Georgia Tech for Macon Telegraph
Northwestern University graduate
TAMPA, Fla. -- Revenge was at the forefront of Troy Tulowitzki's mind when he showed up at George M. Steinbrenner Field on Monday afternoon, and it took him very little time to exact it.
Just two pitches into his first spring training game in two years, the New York Yankees shortstop deposited a pitch just over the right-field wall, narrowly hooking it inside the foul pole.
The leadoff homer was his way of making sure the Toronto Blue Jays, convinced Tulowitzki's best days as a ballplayer were long behind him, understood just how big a mistake they made by cutting him two months ago.
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Over/unders, World Series and playoff odds for all 30 MLB teams
And if he wasn't sure his actions were enough, Tulowitzki did his share of talking after the Yankees' 3-0 win.
"That was the team that basically told me I couldn't play anymore," Tulowitzki said. "You guys know the story. You know what happened. So yeah. No doubt about it. It was definitely extra, extra special."
Tulowitzki called the solo shot "the biggest spring training home run I've ever hit."
The intense, raw emotion he spoke with was on display when he rounded the bases, too. Tulowitzki could be seen shouting loudly as he ran the bases, and he did the same when he came back to the dugout, where he was greeted with high fives and hard pats on the back by teammates.
"Oh, I've been thinking about that at-bat for a long, long time," Tulowitzki said. "So yeah, I got a little pumped up there. But anybody who tells you you're done, you're going to have a little extra fire."
Following two injury-plagued seasons, the Blue Jays released Tulowitzki, 34, in December. They continue, however, to pay him $38 million over the next three seasons. Although he's with the Yankees on a league-minimum $555,000 deal, Tulowitzki is still getting paid more by Toronto than any other player currently on the Blue Jays' roster.
His injury troubles began in 2017, when an ankle sprain cost him much of the second half of that season. Last spring, his heels were the problem. Tulowitzki was forced into having surgery on both to fix bone spur problems. Ultimately, it cost him the entire 2018 season. As a result, Tulowitzki hasn't played in a regular-season game since July 28, 2017.
"All the rehab that I was doing and all the hours that I put in trying to come back from my surgery, there were a lot of people that said, 'Forget about it,'" Tulowitzki said. "There were people who said I'd never make it back on a baseball field again."
Just after he was cut last December, Tulowitzki held workouts that drew interest from multiple teams, including the Yankees, who flew back to where he was training in California to look at him a second time. After that workout, they decided to give him a chance to be their regular shortstop until Didi Gregorius returns from Tommy John surgery.
"He's had that kind of an edge to him, with something to prove really since the first day we put eyes on him this winter," Yankees manager Aaron Boone said. "Again, we're a long way from this thing playing out and seeing how he responds to everything. But the one thing we know we've been looking at, is he's a healthy player.
"To see him go out there for the first time in a long time, and I'm sure there are some jitters and some nerves and all that go with it and a guy of his stature, but to throw that at-bat out there first time and then handle a couple of [defensive] plays -- one really tough play, and to make it look very Tulo-y -- I'm happy for him because I know this day was a big deal."
As for the 19 regular-season games he has coming up against the division-rival Blue Jays this season, Tulowitzki said: "Can't wait."
Throughout his rehab, Tulowitzki said one person has served as motivation above all else: his 5-year-old son, Taz, who was in attendance Monday.
"He was 3 the last time he was watching games, and he [doesn't] remember that," Tulowitzki said. "So to get back out there and have him see me again, that was probably what I thought about each and every day."


text:
Common genetic conditions: a guide for GPs—part 1
By Dr Jude Hayward, Dr Rosalyn Jewell, Dr Schaida SchirwanI2016-09-22T00:00:00+01:00
Drs Rosalyn Jewell, Schaida Schirwani, and Jude Hayward look at the role of GPs in identifying and managing FH, ADPKD, Down syndrome, and AAT deficiency
Dr Rosalyn Jewell
Read this article to learn more about:
the diagnosis and management of familial hypercholesterolaemia, autosomal dominant polycystic kidney disease, Down syndrome, and alpha-1-antitrypsin deficiency
assessing and monitoring patients with genetic conditions, and when to refer
advising patients and their families.
GP commissioning messages
G eneral practitioners play an important role in identifying patients with, or at risk of, common genetic conditions, and in their long-term care. This two-part article series does not aim to provide a comprehensive overview of common genetic conditions, but instead to highlight key management issues relevant to primary care.
Part 1 covers familial hypercholesterolaemia (FH), autosomal dominant polycystic kidney disease (ADPKD), Down syndrome, and alpha-1 antitrypsin (AAT) deficiency. Part 2 (to feature in the October 2016 issue of Guidelines in Practice) covers neurofibromatosis type 1, breast cancer, hereditary haemochromatosis, cystic fibrosis, and conditions with multifactorial inheritance.
Box 1: Terms used in this text1
First-degree relative: a person's sibling, parent, or child
Second-degree relative: a person's grandparent, grandchild, aunt, uncle, nephew, niece, or half sibling.
Familial hypercholesterolaemia
Familial hypercholesterolaemia is an autosomal dominant condition characterised by severely elevated levels of cholesterol from birth, which may lead to premature coronary heart disease (CHD). First-degree relatives (see Box 1, below)1 have a 50% chance of being affected by the condition. The estimated prevalence of FH is 1 in 500 and it is massively underdiagnosed. More than 50% of males will have developed CHD by the age of 50 years and 30% of females by the age of 60.2
Mr C, a 45-year-old man, attends for a vascular check, and his results include a total cholesterol of 8.4 mmol/l and an LDL cholesterol of 5.3 mmol/l.
The Simon Broome criteria are used to make a clinical diagnosis of FH (see Box 2, below).3
Box 2: Simon Broome criteria for a diagnosis of familial hypercholesterolaemia3
Definitive FH
high cholesterol levels (pre-treatment or highest on treatment):
adults over 16 years: total cholesterol levels >7.5 mmol/l or LDL-C >4.9 mmol/l
child less than 16 years of age: total cholesterol levels >6.7 mmol/l or LDL-C >4.0 mmol/l
tendon xanthomas on examination, or in first- or second-degree relative or
DNA-based evidence of an LDL-receptor mutation, familial defective apo B-100, or PCSK9 mutation.
Possible FH
high cholesterol levels as defined above
family history of myocardial infarction at:
age 60 years or younger in a first-degree relative
age 50 years or younger in a second-degree relative
family history of elevated total cholesterol as follows:
greater than 7.5 mmol/l in adult first- or second-degree relative or greater than 6.7 mmol/l in child or sibling aged younger than 16 years.
FH=familial hypercholesterolaemia; LDL-C=low-density lipoprotein cholesterol
Management responsibilities for primary care2
Statins are initial treatment, with a target of reducing low-density lipoprotein cholesterol (LDL-C) by more than 50% of baseline. If this target is not achieved by treatment with high-intensity statins and ezetimibe then specialist referral is appropriate. Lifestyle advice should be part of medical management.
People with features of possible CHD that are not immediately life-threatening should be offered urgent referral to cardiology. Standard CHD risk calculators should not be used, as they will underestimate risk in individuals with FH.
Referral to a specialist with expertise in FH should be offered to those with FH to confirm diagnosis and initiate cascade testing. In many areas, DNA testing is not available and so, at the very least, all first- and second-degree relatives should be advised to have total cholesterol and low-density lipoprotein (LDL-C) levels checked. Cholesterol levels for diagnosis in relatives of an index case are clarified in NICE Clinical Guideline (CG) 71.2
Children with one affected parent should be referred to a specialist clinic by the age of 10 years or at the earliest opportunity thereafter. If both parents are affected then refer by the age of 5 years.
Ongoing assessment and monitoring
On annual review:2
ask about any symptoms suggestive of CHD, consider a baseline ECG, check smoking status
check fasting LDL-C levels
review medications and ask about side-effects
record the progress of cascade testing and update the family history with any changes in CHD status of family members
consider changes in lifestyle and lipid-modifying drug medication that would achieve recommended LDL-C levels.
Recommendations for women and girls with familial hypercholesterolaemia
NICE CG71 recommends that women are given advice and support to include the following:2
when first considering lipid-modifying therapy, discuss the risks for future pregnancy and the fetus. Revisit at least yearly
combined oral contraceptive pills are not contraindicated in FH, but given the small increased risk of cardiovascular events, alternative methods should be considered
women should be advised that lipid-modifying therapy be stopped 3 months before planning to conceive
women who conceive while on lipid-modifying therapy should be advised to stop the medication immediately and offered urgent referral to an obstetrician for appropriate fetal assessment
organise shared-care including cardiology and obstetric input for women who are considering pregnancy or who are pregnant
do not measure serum cholesterol routinely during pregnancy
pregnant women with FH require advice on potential risks and benefits of restarting lipid-modifying drug therapy in pregnancy and when breastfeeding. Bile acid sequestrants (resins) are the only lipid-modifying drug therapy that should be considered during lactation.
Autosomal dominant polycystic kidney disease
Autosomal dominant polycystic kidney disease (ADPKD) is a multisystemic and progressive disorder. The prevalence of the disease has been previously quoted as around 1 in 800,4 but more recent studies suggest a prevalence closer to 1 in 3000 people in the European Union.5 It is highly penetrant, and there is up to a 50% risk of developing end-stage renal disease by the age of 60 years.6 It is characterised by the following:
renal manifestations:
renal cysts
urinary tract infection (UTI), haematuria, and loin pain secondary to renal cysts
end-stage renal disease in 50% of individuals by the age of 60 years
extra-renal manifestations:
cysts in other organs including the liver, pancreas, and spleen7
intracranial aneurysms and other vascular problems such as mitral valve prolapse, aortic root dilatation, or dissection.
Mrs R, a 38-year-old woman, has had a renal ultrasound scan as an investigation for persistent loin pain. The results show bilateral renal cysts, and also four hepatic cysts.
In an individual with a family history of ADPKD in a first-degree relative, diagnosis of ADPKD can be confirmed if imaging criteria are met (see Table 1, below).6–8 If the ultrasound findings are equivocal, then computerised tomography or magnetic resonance imaging may occasionally be indicated.
Table 1: Ultrasound diagnostic criteria for individuals at 50% risk of autosomal dominant polycystic kidney disease8
Minimum number of renal cysts for diagnosis
15–39 Three uni or bilateral cysts
40–59 Two cysts in each kidney
≥60 Four cysts in each kidney
Positive predictive value (PPV) is 100%, sensitivity variable depending on age and genotype
Care and monitoring of patients with ADPKD would usually be undertaken jointly by primary care and renal teams. The mainstay of management in primary care is control of hypertension, and prevention and detection of other complications.
Referral to a geneticist is indicated for counselling of the patient and cascade screening of the family. Genetic testing in ADPKD is complex, and usually indicated only if there is diagnostic doubt, for reproductive reasons, or to exclude the condition in a family member being considered as a potential kidney donor.9
Pregnant women should be referred to an obstetrician. Oestrogens appear to provoke growth of liver cysts, so oestrogen-containing contraceptives and hormone replacement therapy should be avoided9,10
Magnetic resonance angiography is used to detect aneurysms in patients with ADPKD where there is a family history of aneurysm, preparation for major surgery, or a high-risk occupation (e.g. pilot).6,9
Screening echocardiography is used for individuals with heart murmur or for those with a family history of a first-degree relative with a thoracic aortic dissection.6
Long-term administration of nephrotoxic drugs (e.g. non-steroidal anti-inflammatory drugs) and smoking should be avoided.6
Tolvaptan is a selective vasopressin antagonist that has been approved for use by NICE (2015) to slow growth of kidney cysts in those with chronic kidney disease at stage 2 or 3 at start of treatment, and with evidence of rapidly progressive kidney disease.11
Mrs R's 35-year-old brother then comes to see you asking to 'be tested' for the condition.
First-degree relatives of patients with ADPKD are at 50% risk of having the condition. The initial evaluation of at-risk relatives over age 18 years should be renal ultrasound. If the pathogenic variant in the family is known, predictive genetic testing may be appropriate. Prior to screening, at-risk relatives should be counselled on the condition and implications for insurance and employability in future. Normal kidneys on an ultrasound in an individual age 30–39 years or only one renal cyst in an individual age 40 years or older can effectively exclude ADPKD.6–8
At present, screening asymptomatic at-risk children is not recommended.9 However, hypertension can start in childhood, so blood pressure should be monitored from the age of 5 years, with an interval of 3 years when no hypertension is found.9
Down syndrome, or trisomy 21, is usually caused by non-disjunction during meiosis leading to three copies of chromosome 21. The risk of this occurring increases with maternal age. In some cases, mosaic trisomy 21 occurs where not all of the patient's cells have three copies of chromosome 21. In 2–4% of cases, trisomy 21 is caused by a Robertsonian translocation. This is important as it could mean a higher chance of recurrence in a future pregnancy if inherited from a parent. If this is the cause, it will be stated clearly on the karyotype report including the need to test parental samples. There is a 1 in 2 (50%) risk that each child of a women with Down syndrome will also have the condition. Fertility in men with Down syndrome is rare.12,13
Mr T, a 35-year-old man with Down syndrome, attends for his annual learning disabilities review.
There is evidence that a significant proportion of adults with Down syndrome receive inadequate surveillance.14 Annual review should include the health checks offered to all patients with learning disability, particularly body mass index and urinalysis. There are, however, other conditions over-represented in these individuals, for example dementia and coeliac disease, which GPs should be alert to. The Down Syndrome Medical Interest Group and Down's Syndrome Association have produced annual review guidelines.15,16
Alpha-1-antitrypsin deficiency
Alpha-1 antitrypsin (AAT) is a protease inhibitor that inhibits neutrophil elastase. The lack of this inhibition, associated with the effects of cigarette smoke, can lead to pulmonary emphysema. Accumulation of mutant AAT Z proteins in the endoplasmic reticulum of hepatocytes appears to cause liver disease in alpha-1-antitrypsin deficiency.17
A PiZZ genotype is consistent with a clinical diagnosis of AAT deficiency. The common PiMM genotype is found in around 95% of Caucasian people and is associated with normal AAT levels. Alpha-1 antitrypsin deficiency is found in those with PiZZ and PiSS genotypes (0.02–0.06% and 0.01–2.00% of European populations have these genotypes, respectively). The PiSS genotype is associated with AAT levels approximately 60% of normal, those with PiZZ have much lower levels. There are also rare null variants associated with no detectable AAT in the plasma.17
Alpha-1 antitrypsin deficiency is a recessive disorder with 2–5% of the European population being a carrier for the Z allele and 4–11% a carrier for the S allele.17
The key groups where AAT deficiency should be considered are those with early onset emphysema (<=45 years) or those without a risk factor for emphysema and otherwise unexplained liver disease (including in neonates and the elderly).17
Mr H, a 50-year-old man, attends as his brother has recently been found to have AAT deficiency during investigations for chronic obstructive pulmonary disease. Mr H is concerned about his risks and risks to his children.
Mr H is at a 25% risk of having the same genotype as his brother and at risk of clinically relevant respiratory and liver disease. Genotyping and measurement of AAT levels in Mr H are therefore indicated in primary care. Advice should be provided regarding cessation of smoking.
Genotyping shows that Mr H has a PiMZ genotype with normal AAT levels and so is at a lower risk of developing respiratory or liver disease.
Extensive guidance on the diagnosis and management of those with AAT deficiency is available from the American Thoracic Society and European Respiratory Society.17
The genotype of Mr H's children will depend on his partner's status. Genetic testing can be arranged via primary care.
written by Dr David Jenner, GP, Cullompton, Devon
FH is common and underdiagnosed and is a major cause of preventable CVD
GPs should be made aware of the Simon Broome criteria and there should be clear local pathways for referral for suspected FH:
commissioners should ensure the availability of the specific DNA test for diagnosis and cascade testing
A genetic counselling service should be available for direct referral from primary care for people with genetic conditions and people who are identified as being at risk
It would be helpful for GPs to have ready access to guidelines for the identification and management of various rare genetic conditions. These could be made available via a 'referral and formulary app' that allows rapid update and accessibility to multiple local guidelines; some CCGs have already adopted this type of app.
FH=familial hypercholesterolaemia; CVD=cardiovascular disease
US Department of Health and Human Services, National Institutes of Health, National Cancer Institute. Dictionary of genetics terms. Available at: www.cancer.gov/publications/dictionaries/genetics-dictionary
NICE. Identification and management of familial hypercholesterolaemia. Clinical Guideline 71. NICE, 2008. Available at: www.nice.org.uk/guidance/CG71
Heart UK. Diagnostic criteria for familial hypercholesterolaemia using Simon Broome register. Available at: heartuk.org.uk/files/uploads/documents/HUK_AS04_Diagnostic.pdf
Dalgaard O. Bilateral polycystic disease of the kidneys; a follow-up of two hundred and eighty-four patients and their families. Acta Med Scand Suppl 1957; 158 (328): 1–255.
Willey C, Blais J, Hall A et al. Prevalence of autosomal dominant polycystic kidney disease in the European Union. Nephrol Dial Transplant, 2016, Epub 19 Jun. Available at: ndt.oxfordjournals.org/content/early/2016/06/19/ndt.gfw240.full.pdf+html
Harris P, Torres V. Polycystic kidney disease, autosomal dominant. In: Pagon R, Adam M, Ardinger H et al, editors. GeneReviews®. Seattle (WA): University of Washington, Seattle, 2002: 1993–2016. Available at: www.ncbi.nlm.nih.gov/books/NBK1246/
Mosetti M, Leonardou P, Motohara T et al. Autosomal dominant polycystic kidney disease: MR imaging evaluation using current techniques. J Magn Reson Imaging 2003; 18 (2): 210–215.
Pei Y, Obaji J, Dupuis A et al. Unified criteria for ultrasonographic diagnosis of ADPKD. J Am Soc Nephrol 2009; 20: 205–212. Available at: doi.org/10.1681/ASN.2008050507
Chapman A, Devuyst O, Eckardt K et al. Autosomal-dominant polycystic kidney disease (ADPKD): executive summary from a kidney disease: improving global outcomes (KDIGO) controversies conference. Kidney Int 2015, 88 (1): 17–27.
Alvaro D, Mancino M, Onori P et al: Estrogens and the pathophysiology of the biliary tree. World J Gastroenterol 2006; 12: 3537–3545. Available at: www.ncbi.nlm.nih.gov/pmc/articles/PMC4087569/
NICE. Tolvaptan for treating autosomal dominant polycystic kidney disease. NICE Technology Appraisal 358. NICE, 2015. Available at: www.nice.org.uk/ta358
Asim A, Kumar A, Muthuswamy S et al. Down syndrome: an insight of the disease. J Biomed Sci 2015, 22: 41. Available at: www.ncbi.nlm.nih.gov/pmc/articles/PMC4464633
Firth H, Hurst J, Bobrow M. Down syndrome (trisomy 21). In: Hall JG, editor. Oxford Desk Reference Clinical Genetics. Oxford: Oxford University Press, 2005: 524–525.
Henderson A, Lynch S, Wilkinson S, Hunter M. Adults with Down's syndrome: the prevalence of complications and health care in the community. BJGP 2007; 57: 50–55.
Down's Syndrome Medical Interest Group. Guidance for essential medical surveillance. Available at: www.dsmig.org.uk/information-resources/guidance-for-essential-medical-surveillance/ (accessed 11 August 2016).
Down's Syndrome Association. For professionals: annual health check information for GPs. Available at: www.downs-syndrome.org.uk/for-professionals/health-medical/annual-health-check-information-for-gps/ (accessed 11 August 2016).
American Thoracic Society/European Respiratory Society Task Force. American Thoracic Society/European Respiratory Society statement: Standards for the diagnosis and management of individuals with alpha-1 antitrypsin deficiency. Am J Respir Crit Care Med 2003; 168 (7): 818–900. Available at: www.atsjournals.org/doi/pdf/10.1164/rccm.168.7.818G
Hypercholesterolaemia
Drs Rosalyn Jewell, Schaida Schirwani, and Jude Hayward discuss key aspects of genetic conditions, including breast cancer and cystic fibrosis, that GPs should be aware of
Familial hypercholesterolaemia: case finding, assessment, and management
Sadaf Qureshi and Dr Nadeem Qureshi review updated NICE guidance on familial hypercholesterolaemia and discuss the importance of proactive identification of this patient group in primary care
NICE updates guidance on familial hypercholestrolaemia
NICE has updated Clinical Guideline (CG) 71 on Familial hypercholesterolaemia: identification and management. Familial hypercholesterolaemia (FH) is a genetic disorder characterised by high cholesterol levels from birth, putting affected individuals at increased risk of developing cardiovascular


ValuEngine lowered shares of Mobile Mini (NASDAQ:MINI) from a hold rating to a sell rating in a research note published on Friday, March 22nd, ValuEngine reports.
Several other research analysts have also issued reports on the stock. Zacks Investment Research lowered shares of Mobile Mini from a hold rating to a sell rating in a research note on Tuesday, March 19th. BidaskClub lowered shares of Mobile Mini from a hold rating to a sell rating in a research note on Saturday, March 9th. TheStreet downgraded shares of Mobile Mini from a b rating to a c rating in a report on Friday, February 1st. Finally, Oppenheimer lowered their target price on shares of Mobile Mini from $47.00 to $40.00 and set an outperform rating for the company in a report on Monday, February 4th. Four investment analysts have rated the stock with a sell rating, two have given a hold rating and three have issued a buy rating to the company's stock. Mobile Mini currently has an average rating of Hold and an average target price of $47.33.
MINI stock traded down $0.30 during trading on Friday, reaching $33.50. 259,206 shares of the company were exchanged, compared to its average volume of 199,314. The company has a debt-to-equity ratio of 0.38, a current ratio of 0.21 and a quick ratio of 0.19. Mobile Mini has a twelve month low of $29.46 and a twelve month high of $50.40. The stock has a market cap of $1.52 billion, a price-to-earnings ratio of 20.43, a P/E/G ratio of 1.24 and a beta of 1.75.
Mobile Mini (NASDAQ:MINI) last issued its earnings results on Friday, February 1st. The industrial products company reported $0.53 earnings per share (EPS) for the quarter, missing the Thomson Reuters' consensus estimate of $0.57 by ($0.04). The company had revenue of $160.90 million for the quarter, compared to the consensus estimate of $155.55 million. Mobile Mini had a positive return on equity of 8.74% and a negative net margin of 1.36%. The firm's revenue was up 9.7% compared to the same quarter last year. During the same period in the prior year, the company earned $0.41 earnings per share. On average, equities research analysts anticipate that Mobile Mini will post 1.96 EPS for the current fiscal year.
A number of hedge funds and other institutional investors have recently bought and sold shares of MINI. Norges Bank purchased a new stake in Mobile Mini during the fourth quarter worth about $12,560,000. SG Capital Management LLC purchased a new stake in Mobile Mini during the fourth quarter worth about $7,659,000. BlackRock Inc. increased its holdings in Mobile Mini by 2.7% during the third quarter. BlackRock Inc. now owns 6,466,128 shares of the industrial products company's stock worth $283,539,000 after buying an additional 168,061 shares during the last quarter. Millennium Management LLC increased its holdings in Mobile Mini by 285.0% during the fourth quarter. Millennium Management LLC now owns 163,057 shares of the industrial products company's stock worth $5,177,000 after buying an additional 120,702 shares during the last quarter. Finally, Vanguard Group Inc increased its holdings in Mobile Mini by 2.0% during the third quarter. Vanguard Group Inc now owns 4,610,861 shares of the industrial products company's stock worth $202,187,000 after buying an additional 91,893 shares during the last quarter. Institutional investors and hedge funds own 98.52% of the company's stock.


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