text:
Uncovering genes with divergent mRNA-protein dynamics in Streptomyces coelicolor
Karthik P. Jayapal, Robin J. Philp, Yee Jiun Kok, Miranda G S Yap, David H. Sherman, Timothy J. Griffin, Wei Shou Hu
Biochemistry, Molecular Biology, and Biophysics (TMED)
Chemical Engineering and Materials Science
Stem Cell Institute
Many biological processes are intrinsically dynamic, incurring profound changes at both molecular and phsyiological levels. Systems analyses of such processes incorporating large-scale transcriptome or proteome profiling can be quite revealing. Although consistency between mRNA and proteins is often implicity assumed in many studies, examples of divergent trends are frequently observed. Here, we present a comparative transcriptome and proteome analysis of growth and stationary phase adaptation in Streptomyces coelicolor, taking the time-dynamics of process into consideration. These processes are of immense interest in microbiology as they pertain to the physiological transformations eliciting biosynthesis of many naturally occurring therapeutic agents. A shotgun proteomics approach based on mass spectrometric analysis of isobaric stable isotope labeled peptides (ITRAQ™) enabled identification and rapid quantification of approximately 14% of the theoretical proteome of S. coelicolor. Independent principal component analyses of this and DNA microarray-derived transcriptome data revealed that the prominent patterns in both protein and mRNA domains are surprisingly well correlated. Despite this overall correlation, by employing a systematic concordance analysis, we estimated that over 30% of the analyzed genes likely exhibited significantly divergent patterns, of which nearly one-third displayed even opposing trends. Integrating this data with biological information, we discovered that certain groups of functionally related genes exhibit mRNA-protein discordance in a similar fashion. Our observations suggest that differences between mRNA and protein synthesis/degradation mechanisms are prominent in microbes while reaffirming the plausibility of such mechanisms acting in a concerted fashion at a protein complex or sub-pathway level.
We are grateful to Dr. LeeAnn Higgins and Dr. Lorraine B. Anderson of the Center for Mass Spectrometry and Proteomics (University of Minnesota, USA) and Ms. Zheng Lu of the Bioprocessing Technology Institute (A*STAR, Singapore) for their technical assistance with mass spectrometry. Bioinformatics support was provided by the University of Minnesota Supercomputing Institute.
Dive into the research topics of 'Uncovering genes with divergent mRNA-protein dynamics in Streptomyces coelicolor'. Together they form a unique fingerprint.
Streptomyces coelicolor Medicine & Life Sciences 100%
Proteome Medicine & Life Sciences 51%
transcriptomics Agriculture & Biology 39%
Gene Expression Profiling Medicine & Life Sciences 34%
microbiology Agriculture & Biology 24%
Jayapal, K. P., Philp, R. J., Kok, Y. J., Yap, M. G. S., Sherman, D. H., Griffin, T. J., & Hu, W. S. (2008). Uncovering genes with divergent mRNA-protein dynamics in Streptomyces coelicolor. PloS one, 3(5), [e2097]. https://doi.org/10.1371/journal.pone.0002097
Uncovering genes with divergent mRNA-protein dynamics in Streptomyces coelicolor. / Jayapal, Karthik P.; Philp, Robin J.; Kok, Yee Jiun et al.
In: PloS one, Vol. 3, No. 5, e2097, 07.05.2008.
Jayapal, KP, Philp, RJ, Kok, YJ, Yap, MGS, Sherman, DH, Griffin, TJ & Hu, WS 2008, 'Uncovering genes with divergent mRNA-protein dynamics in Streptomyces coelicolor', PloS one, vol. 3, no. 5, e2097. https://doi.org/10.1371/journal.pone.0002097
Jayapal KP, Philp RJ, Kok YJ, Yap MGS, Sherman DH, Griffin TJ et al. Uncovering genes with divergent mRNA-protein dynamics in Streptomyces coelicolor. PloS one. 2008 May 7;3(5):e2097. doi: 10.1371/journal.pone.0002097
Jayapal, Karthik P. ; Philp, Robin J. ; Kok, Yee Jiun et al. / Uncovering genes with divergent mRNA-protein dynamics in Streptomyces coelicolor. In: PloS one. 2008 ; Vol. 3, No. 5.
@article{e1260a65bec54ebda88c7cf0195a5223,
title = "Uncovering genes with divergent mRNA-protein dynamics in Streptomyces coelicolor",
abstract = "Many biological processes are intrinsically dynamic, incurring profound changes at both molecular and phsyiological levels. Systems analyses of such processes incorporating large-scale transcriptome or proteome profiling can be quite revealing. Although consistency between mRNA and proteins is often implicity assumed in many studies, examples of divergent trends are frequently observed. Here, we present a comparative transcriptome and proteome analysis of growth and stationary phase adaptation in Streptomyces coelicolor, taking the time-dynamics of process into consideration. These processes are of immense interest in microbiology as they pertain to the physiological transformations eliciting biosynthesis of many naturally occurring therapeutic agents. A shotgun proteomics approach based on mass spectrometric analysis of isobaric stable isotope labeled peptides (ITRAQ{\texttrademark}) enabled identification and rapid quantification of approximately 14% of the theoretical proteome of S. coelicolor. Independent principal component analyses of this and DNA microarray-derived transcriptome data revealed that the prominent patterns in both protein and mRNA domains are surprisingly well correlated. Despite this overall correlation, by employing a systematic concordance analysis, we estimated that over 30% of the analyzed genes likely exhibited significantly divergent patterns, of which nearly one-third displayed even opposing trends. Integrating this data with biological information, we discovered that certain groups of functionally related genes exhibit mRNA-protein discordance in a similar fashion. Our observations suggest that differences between mRNA and protein synthesis/degradation mechanisms are prominent in microbes while reaffirming the plausibility of such mechanisms acting in a concerted fashion at a protein complex or sub-pathway level.",
author = "Jayapal, {Karthik P.} and Philp, {Robin J.} and Kok, {Yee Jiun} and Yap, {Miranda G S} and Sherman, {David H.} and Griffin, {Timothy J.} and Hu, {Wei Shou}",
note = "Funding Information: We are grateful to Dr. LeeAnn Higgins and Dr. Lorraine B. Anderson of the Center for Mass Spectrometry and Proteomics (University of Minnesota, USA) and Ms. Zheng Lu of the Bioprocessing Technology Institute (A*STAR, Singapore) for their technical assistance with mass spectrometry. Bioinformatics support was provided by the University of Minnesota Supercomputing Institute.",
T1 - Uncovering genes with divergent mRNA-protein dynamics in Streptomyces coelicolor
AU - Jayapal, Karthik P.
AU - Philp, Robin J.
AU - Kok, Yee Jiun
AU - Yap, Miranda G S
AU - Sherman, David H.
AU - Griffin, Timothy J.
AU - Hu, Wei Shou
N1 - Funding Information: We are grateful to Dr. LeeAnn Higgins and Dr. Lorraine B. Anderson of the Center for Mass Spectrometry and Proteomics (University of Minnesota, USA) and Ms. Zheng Lu of the Bioprocessing Technology Institute (A*STAR, Singapore) for their technical assistance with mass spectrometry. Bioinformatics support was provided by the University of Minnesota Supercomputing Institute.
N2 - Many biological processes are intrinsically dynamic, incurring profound changes at both molecular and phsyiological levels. Systems analyses of such processes incorporating large-scale transcriptome or proteome profiling can be quite revealing. Although consistency between mRNA and proteins is often implicity assumed in many studies, examples of divergent trends are frequently observed. Here, we present a comparative transcriptome and proteome analysis of growth and stationary phase adaptation in Streptomyces coelicolor, taking the time-dynamics of process into consideration. These processes are of immense interest in microbiology as they pertain to the physiological transformations eliciting biosynthesis of many naturally occurring therapeutic agents. A shotgun proteomics approach based on mass spectrometric analysis of isobaric stable isotope labeled peptides (ITRAQ™) enabled identification and rapid quantification of approximately 14% of the theoretical proteome of S. coelicolor. Independent principal component analyses of this and DNA microarray-derived transcriptome data revealed that the prominent patterns in both protein and mRNA domains are surprisingly well correlated. Despite this overall correlation, by employing a systematic concordance analysis, we estimated that over 30% of the analyzed genes likely exhibited significantly divergent patterns, of which nearly one-third displayed even opposing trends. Integrating this data with biological information, we discovered that certain groups of functionally related genes exhibit mRNA-protein discordance in a similar fashion. Our observations suggest that differences between mRNA and protein synthesis/degradation mechanisms are prominent in microbes while reaffirming the plausibility of such mechanisms acting in a concerted fashion at a protein complex or sub-pathway level.
AB - Many biological processes are intrinsically dynamic, incurring profound changes at both molecular and phsyiological levels. Systems analyses of such processes incorporating large-scale transcriptome or proteome profiling can be quite revealing. Although consistency between mRNA and proteins is often implicity assumed in many studies, examples of divergent trends are frequently observed. Here, we present a comparative transcriptome and proteome analysis of growth and stationary phase adaptation in Streptomyces coelicolor, taking the time-dynamics of process into consideration. These processes are of immense interest in microbiology as they pertain to the physiological transformations eliciting biosynthesis of many naturally occurring therapeutic agents. A shotgun proteomics approach based on mass spectrometric analysis of isobaric stable isotope labeled peptides (ITRAQ™) enabled identification and rapid quantification of approximately 14% of the theoretical proteome of S. coelicolor. Independent principal component analyses of this and DNA microarray-derived transcriptome data revealed that the prominent patterns in both protein and mRNA domains are surprisingly well correlated. Despite this overall correlation, by employing a systematic concordance analysis, we estimated that over 30% of the analyzed genes likely exhibited significantly divergent patterns, of which nearly one-third displayed even opposing trends. Integrating this data with biological information, we discovered that certain groups of functionally related genes exhibit mRNA-protein discordance in a similar fashion. Our observations suggest that differences between mRNA and protein synthesis/degradation mechanisms are prominent in microbes while reaffirming the plausibility of such mechanisms acting in a concerted fashion at a protein complex or sub-pathway level.
M1 - e2097


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Best Fashion Companies in Leicester (2021)
I. Top Leicester Fashion Companies
I.I. EROX LTD
I.II. Shoe Zone
I.III. Option Systems
I.IV. Next
I.V. Duffle Coats UK
I.VI. Firebrand Fashion
I.VII. Universal Textiles UK Ltd
I.VIII. Teez.by
I.IX. LOTD Ltd
I.X. Wearable Technologies
I.XI. Related
This article showcases our top picks for the best Leicester based Fashion companies. These startups and companies are taking a variety of approaches to innovating the Fashion industry, but are all exceptional companies well worth a follow.
Top Leicester Fashion Companies
EROX LTD
Stay ahead of the trends and shop in a convenient, simple and reliable manner with EROX! Fashion.
Shoe Zone is a value footwear retailer that sells a vast range of shoes for all ages. With over 500 stores across the UK, Shoe Zone sells over 20 million pairs of shoes a year.
In 2010, the Smith family celebrated 30 years of ownership of the Shoe Zone business. Before they acquired Bensonshoe in 1980, its annual sales were £1.6 million and it had 48 stores based in Central England.
In 2000, the trading name was changed to Shoe Zone and a new cleaner shopfit was developed, creating an easy to shop, classless environment in which customers felt at home shopping for value shoes. This, coupled with continuous improvements in product quality and value, set the scene for an exciting new decade of growth.
In March 2010, Shoe Zone entered multi-channel retailing with the launch of its first transactional website.. .
Option Systems
Option Systems specialized in computer systems for clothing and footwear businesses.
Next is engages in the retail of clothing, footwear, accessories, and home products for men, women, and children.
Duffle Coats UK
Duffle Coats UK sell an authentic original Montgomery duffle coat, which is handmade in England using the finest materials. It is a British classic that remains at the forefront of fashion across the globe.
The Duffle coats offer a classic design combined with superior quality materials and workmanship, manufactured at the original and world's oldest duffle coat manufacturer. All Montgomery duffle coats are handmade in the UK.
Our Duffles are stylish, warm, windproof and robust. These winter coats are stylish and comfortable authentic montgomery duffel coats.
Take a look at the video, which showcases the quality of our duffle coats, and if you are interested to know about the history of duffles make sure you have a good read through the short history presentation.. .
Firebrand Fashion
Firebrand Fashion offer a wide range of designer and fashion brand clothing to consumers online.
Universal Textiles UK Ltd
Universal Textiles primarily began wholesaling a diverse range of hosiery products in and around Leicester after their inception in 1986. In 2005, they established an internet presence selling retail to customers within the United Kingdom.
They have recently expanded their distribution facilities in Leicester now sells other products like Scarves, nightwear and children's pyjamas, underwear, tights, dresses, footwear, winter hats, work wear, caps and baby wear. They invite you to peruse and look forward to servicing your needs..
Teez.by
Create one-off custom T-Shirts with photos uploaded from your computer or mobile app. – The Moo.com for T-Shirts! Aimed at the consumer, photo app developers, and Business to Business (B2B) content owners.
Our mission – To make the process of creating a custom tee as simple as possible: 'Upload' image -> 'Choose' the garment -> 'Buy' Custom Tee. We offer a complete 'White Label' solution for our B2B partners.
There is No registration, No setup fee, No stock holding, No minimums, No charge for Facebook or website integration. The Clickteez platform has been created from the ground up to enable third-parties to use our API for their own apps / websites, and earn revenue from the sale of the finished garment.
Our websites: http://clickteez.me http://teez.by http://instateez.me http://faceteez.me You can upload an image from your computer or link to your Instagram or Facebook photos and make a custom tee at the click of a button. The focus now is to develop the business to prepare it for rapid growth worldwide, as we form alliances with new B2B content partners..
LOTD Ltd
Leading women's fashion brand based in the UK.
Wearable Technologies Limited designs, manufactures, and distributes intelligent clothing that are embedded with washable electronics. With over 50 granted patents in the field of fabric sensor controls, WTL are an early leader in embedding washable electronics into a varied range of intelligent clothing for consumer, industrial safety and emergency services.
WTL products are sold around the world in retailers such as Halfords, Cycle Republic and Evans Cycles in the UK, and MoMA (Museum of Modern Art) and Dicks Sporting Goods in the USA, used by workers in industry, local government, the military and the police. WTL model is to BUILD their patented technologies within Wearable Technologies Limited, PROVE them in their own Visijax-branded products (www.visijax.com) to end customers, and then gain SCALE through LICENSING them to other garment manufacturers wishing to enter this exploding market to sell into their own verticals eg.
consumer, oil & gas, transport, construction. WTL developing an embedded smart garment plug and play IoT platform to make the "connected worker" a reality, assisted by Mediatek (processors), Orange (data and connectivity in 200 countries), Accenture (systems integration into large enterprise control rooms).
Within the company they have a blend of mass market garment manufacture, hardware, software, data and IP competencies. Wearable Technologies Limited business is focused on building the wearable technologies of the future..
Best Food and Beverage Companies in Leicester (2021)
Best Digital Marketing Companies in Leicester (2021)

redpajama_set_name: RedPajamaCommonCrawl


text:
Kalamazoo Speedway Cancels Due to Extreme Heat for Friday, July 22
In the interest of safety for fans and competitors alike, Kalamazoo Speedway officials are cancelling the races for Friday, July 22. With heat index temperatures expected to reach or exceed 100 degrees, conditions would be miserable and dangerous not only for fans but also for the teams and drivers. The National Weather Service has issued a Heat Advisory, which runs into Friday evening stating, "PROLONGED EXPOSURE TO THE OUTDOOR HEAT COULD BE DANGEROUS……MAKING HEAT EXHAUSTION OR HEAT STOKE POSSIBLE." One of our main goals each week is to have a clean, safe, fun atmosphere for drivers, spectators and track employees. With the predicted conditions it will not be possible to do that. Please shoot a text or phone call to anyone that you know who usually comes out to the Zoo and let them know we have cancelled for this Friday. Enjoy your week off and we will see you next Friday, July 29th at 7:30 PM!
Action continues next Friday, July 29 with another 6 in 1 NASCAR Racing Program featuring the NASCAR Whelen All-American Series Outlaw Super Late Models, Super Stocks, Pro Stocks, the Southwest Michigan Mini Stock Challenge Series, Outlaw Cyber Stocks and Flip Flop Cyber Stocks. It will also be Motorcycle Night, where anyone driving a motorcycle to the track will be admitted for FREE and will be welcome to drive their motorcycle around the track during the intermission.
Kalamazoo Speedway is the place to be in 2016 for fast, clean, family fun! Pick up a copy of the Kalamazoo Speedway schedule at the ticket office or look it up at www.kalamazoospeedway.com. Kalamazoo Speedway plays host to some of the best entertainment events in the State and welcomes corporate groups, family outings and suite rentals. Call 269-692-2423 Monday through Friday to learn more or visit the Kalamazoo Speedway website.
For all the latest news and contests check out www.facebook.com/KalamazooSpeedway.
You can also follow Kalamazoo Speedway at www.twitter.com/kzoospeedway.


The 2019 Masters starts today, starting off the 83rd edition of this storied event at Augusta National. While this tournament does have the smallest field of any of the four golf majors, it has all the best talent on tour.
It's a tough major to predict a winner for, but some players are currently standing out as having the most potential to win the Masters in 2019.
The odds for the 2019 Masters have shifted a bit since initially being released. Rory McIlroy opened as the top choice to complete a career Grand Slam by winning at Augusta National this week at +700, but has since seen his line slip slightly. The 29-year-old is now going off at +800, tying him with another elite golfer that has yet to win a green jacket in Rickie Fowler.
On the other hand, Tiger Woods has been on everyone's mind. Tiger Woods will have a lot of supporters when he plays at the Masters this weekend, both at Augusta National and watching at home.
Fun fact: an unidentified Nevada citizen placed an $85,000 bet on Tiger Woods winning the Masters. That's not a small amount of money to wager on anything, but the reward is huge. With the odds at 14-1, the payout would be a massive $1,190,000.
Tiger has been on the come up from his injury and his DUI. He won last year in the final tournament of the 2018 golf season. He has been on a mission and wants to regain yet another green jacket.
I want Tiger to win that jacket. He has had a huge come back for his career and I think he's still getting better.


The beta in order to permit Windows 10 and Android Minecraft players to play collectively is now live.
The beta is step one in Microsoft's Better Together Minecraft improve, which ambitions to unite Minecraft on the console, Windows 10, and Android. The Xbox One beta could be rolling out within the coming days.
Not all of Better Together's functions will be available within the beta (servers aren't staying) but they are being delivered as they end up geared up.
The Better Together improve for Minecraft was introduced at E3 this 12 months. The upgrade will deliver the console and Windows 10/Android versions into the Bedrock Engine family, designed for cross-platform play. For the overall breakdown of Minecraft's Better Together update, take a look at out the FAQ.
Windows is the maximum famous running device for PCs and laptops whilst Android is the maximum extensively used platform for the smartphones and capsules.
Many humans nevertheless depend upon Windows apps for distinct functions but are it viable to apply them on hand held devices?
Yes! You can do it with a fast net connection and a virtualization software. Here I will comprehensively manual you how.
Connect your Windows gadget to your Smartphone or pill using Microsoft Remote Desktop app.
This software offers you get right of entry to all the applications established on your PC, however, it really works handiest with the positive version of Windows. Particularly for Windows 7, you may want Ultimate, Professional, and Enterprise even as for Windows 8; this software is to be had in Pro and Enterprise variations only. In Windows 10, this application isn't always to be had natively.
Given the truth that most of the people use domestic or primary variants on their PCs, it isn't a perfect option.
Although Remote Desktop apps can be used on all Android devices, it will be better in case you join a tablet to your PC using this software program instead of a cell phone due to the fact you may need to zoom and pan over and over whilst looking to navigate a Windows that's a fairly difficult assignment to do on a small display.
After connecting the 2 gadgets, you can run Windows applications the use of Crossover, a software evolved by CodeWeavers. This application turned into considered as a useful tool to run Windows packages on Mac or LINUX in past and made its look on Android simply at the top of the remaining year.
Crossover requires an x86 processor and at the least 2GB of RAM to run maximum real-global Windows packages, which limits the supply of this selection to positive Android devices.
Like Crossover, any other software program WINE, which is used to run Windows applications on LINUX, is likewise poised to make inroads to Android quickly.
There are numerous tablets inside the marketplace which allow you to switch among Windows and Android operating systems.
Cube i10 is one of the popular twin-boot capsules. Powered via Intel Z3735 Quad Core 1.8GHz processor, this 10.6-inch tool runs on Android four.4.Four and Windows eight.1 Bing, features 2GB RAM and 32 GB ROM and springs up with a feed tag of $130.
You can search more dual-boot capsules on the web sites like GearBest, Geekbuying, and TinyDeal.
Each developer has to focus on numerous elements to make his cell app a hit and worthwhile. In addition to concentrating on the app's look, sense, features and performance, he also desires to goal the right cell platform. But the selection of cell running structures differs from one programmer to every other. Some builders decide upon constructing apps for the most famous cellular working machine, while others goal multiple cellular operating structures.
In terms of global market proportion, iOS, Android and Windows Phone are the three maximum famous cell working systems of 2015. However, there may be a massive difference in the worldwide market share of each cellular platform. Likewise, the functions functionality of each cell working system also differs from others. That is why; it will become vital for cellular app developers to recognize a number of the maximum crucial differences between iOS, Android and Windows Phone.
Apple introduced iPhone OS in June 2008. In June 2010, Apple renamed iPhone OS as iOS and made the cell working device assist iPhone, iPad and iPod Touch. Google launched the primary commercial model of Android in September 2008. Microsoft released Windows Phone in October 2010. So Windows Phone is comparatively more youthful than other cellular systems. However, the three mobile running systems are being updated on a normal foundation. Apple, Google, and Microsoft have already made pre-launch beta variations of iOS 9, Android M and Windows 10 Mobile to programmers.
As a long listing of reports has highlighted, Android is currently the most popular mobile operating device within the marketplace. According to the trendy records posted by using the International Data Company (IDC), Android dominates the global mobile OS marketplace with a share of seventy-eight%. On the other hand, the worldwide cell OS market share of Apple is 18.3%, and Windows Phone is two.7%. The popularity and marketplace proportion of each cell OS maintain fluctuating. But Android nonetheless has a much higher international marketplace share than both Android and Windows Phone.
Google goes to make it a chunk easier to check the battery degree on Bluetooth devices related to your telephone.


text:
Gabriela Masłowska z domu Szczuka (ur. 27 czerwca 1950 w Batorzu) – polska polityk, ekonomistka, nauczycielka akademicka, posłanka na Sejm IV, V, VI, VII, VIII i IX kadencji, członek Rady Polityki Pieniężnej w kadencji 2022–2028.

Życiorys

Wykształcenie i praca zawodowa
W 1974 ukończyła studia na Wydziale Ekonomicznym Uniwersytetu Marii Curie-Skłodowskiej w Lublinie. W 1982 uzyskała na tej uczelni stopień doktora nauk ekonomicznych na podstawie pracy pt. Skala produkcji a efektywność gospodarowania w indywidualnych gospodarstwach specjalistycznych. Od 1974 do 1976 była asystentem w Instytucie Rozwoju Wsi i Rolnictwa Polskiej Akademii Nauk. Od 1976 do 1980 wykładała na UMCS, a następnie została adiunktem na Wydziale Agrobioinżynierii Uniwersytetu Przyrodniczego w Lublinie. Jako wykładowczyni związana także z Wyższą Szkołą Kultury Społecznej i Medialnej w Toruniu.

W 1997 została wiceprzewodniczącą Ogólnopolskiego Forum Stowarzyszeń Uwłaszczeniowych, a w 1998 objęła funkcję prezesa Obywatelskiego Stowarzyszenia Uwłaszczeniowego w Lublinie. Została też publicystką m.in. Radia Maryja.

Działalność polityczna
W latach 2001–2007 była posłanką IV i V kadencji, mandat uzyskiwała z listy Ligi Polskich Rodzin (otrzymała kolejno: 12 243 i 11 977 głosów). W kwietniu 2006 została wykluczona z LPR. Zasiadała w Narodowym Kole Parlamentarnym. 22 września 2006 przystąpiła do powstałego wówczas klubu parlamentarnego Ruchu Ludowo-Narodowego. 18 grudnia 2006 wstąpiła do koła Ruch Ludowo-Chrześcijański. W 2007 była wiceprezesem partii Ruch Ludowo-Narodowy.

W wyborach parlamentarnych w 2007 po raz trzeci uzyskała mandat poselski. Kandydując z listy Prawa i Sprawiedliwości (jako przedstawicielka RLN) w okręgu lubelskim, otrzymała 18 743 głosy. W 2011 wstąpiła do PiS. W wyborach parlamentarnych w tym samym roku ponownie uzyskała reelekcję z listy tej partii, otrzymując 17 777 głosów. W 2015 również została wybrana do Sejmu (dostała 23 287 głosów). Mandat poselski utrzymała także w wyborach w 2019 (poparło ją wówczas 14 446 osób).

W 2022 dwukrotnie zgłaszana przez posłów PiS do Rady Polityki Pieniężnej. Za pierwszym razem w lutym tegoż roku zrezygnowała z kandydowania. Za drugim razem w październiku 2022 została wybrana przez Sejm do tego gremium na sześcioletnią kadencję; w konsekwencji wygasł jej mandat poselski.

Publikacje
 Makroekonomia gospodarki rynkowej, Lublin 1996.
 Rozpoznanie nisz gospodarczych i przestrzennych jako element polityki regionalnej na przykładzie województwa lubelskiego, Lublin 1999.

Życie prywatne
Jest mężatką, ma dwoje dzieci.

Przypisy

Bibliografia

Linki zewnętrzne

Absolwenci Uniwersytetu Marii Curie-Skłodowskiej
Członkowie Rady Polityki Pieniężnej
Ludzie związani z Radiem Maryja
Politycy Ligi Polskich Rodzin
Politycy Prawa i Sprawiedliwości
Politycy Ruchu Ludowo-Narodowego
Polscy ekonomiści
Posłowie z okręgu Lublin
Wykładowcy Uniwersytetu Marii Curie-Skłodowskiej
Wykładowcy Uniwersytetu Przyrodniczego w Lublinie
Wykładowcy Wyższej Szkoły Kultury Społecznej i Medialnej w Toruniu
Urodzeni w 1950
Ludzie urodzeni w Batorzu

redpajama_set_name: RedPajamaWikipedia


text:
Are Nutraceuticals Effective in Controlling Essential Hypertension? | OMICS International
Clinical Pharmacology & Biopharmaceutics
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Are Nutraceuticals Effective in Controlling Essential Hypertension?
Antoine Al-Achi*
College of Pharmacy and Health Sciences, Campbell University, NC 27506, USA
Antoine Al-Achi
Campbell University, P.O. Box 1090, Buies Creek
NC 27506, USA
Received date: June 15, 2017; Accepted date: June 16, 2017; Published date: June 20, 2017
Citation: Al-Achi A (2017) Are Nutraceuticals Effective in Controlling Essential Hypertension?. Clin Pharmacol Biopharm 6:e128. doi: 10.4172/2167-065X.1000e128
Copyright: © 2017 Al-Achi A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Visit for more related articles at Clinical Pharmacology & Biopharmaceutics
According to the U.S. Centres for Disease Control and Prevention (CDC), the prevalence of essential hypertension (adults, 20 years of age or older) in the U.S.A. was estimated to be 33.5% (2013-2014 data), with an estimated death rate of 9.5 per 100,000 due to this illness [1]. The CDC reports also state that the occurrence of this disease in the population varies by age, gender, and ethnicity. Older persons, males (up to the age of 45 years), and African-Americans suffer from this condition the most [2]. Treating hypertension with antihypertensive drugs has been the mainstay for managing individuals with this condition. Surveys in the U.S.A. have shown that clinician's choice for selecting a particular antihypertensive medication was not correlated with age, gender, ethnicity, or the medical insurance the patient had [3]. Moreover, the most prescribed medications were (in descending order) angiotensin-converting enzyme inhibitors, thiazide diuretics, angiotensin receptor blockers, calcium-channel blockers, and betablockers [3]. It is interesting to note that hypertension and osteoporosis, both are frequently encountered in older patomicsonline.orgients, share similar risk factors of genetic predisposition and environmental conditions. Moreover, antihypertensive medications can influence, positively or negatively, the bone mineral density in patients with osteoporosis [4]. In this editorial, the use of some nutraceuticals by patients suffering from essential hypertension is briefly discussed.
L-arginine is an amino acid that was shown to cause a reduction in blood pressure in experimental animals and clinical studies following oral or intravenous administration. L-arginine reduces blood pressure by enhancing the production of Nitric Oxide (NO) which in turn yields to endothelium smooth muscle relaxation [5].
Beetroot (Beta vulgaris) is highly rich in nitrate and was shown to cause a reduction in blood pressure via NO vasodilatory action [6].
Calcium, as a mineral, is a highly critical regulator for many bodily functions. When the calcium level in the body is high, it yields to enhanced sodium excretion which results in a decreased intravascular volume. This lower volume produces a reduction in blood pressure through a lowering of intravascular resistance [4].
Celery (Apium graveolens L.) is a good source of magnesium [7]. The active constituent in celery that was shown to cause a reduction in blood pressure was n-butylphthalide [8].
Garlic (Allium sativum) was shown to significantly reduce blood pressure in patients with high blood pressure, and its effectiveness was as powerful as those of anti-hypertensive medications. The mechanisms of action of garlic in reducing blood pressure, mainly due to the components allicin and S-allyl cysteine, are numerous and include NO regulation as well as calcium channel blocking action [6].
Hawthorn (Crataegus laevigata) extract was shown to reduce significantly diastolic, but not systolic, blood pressure in patients who had Type 2 diabetes [9].
Magnesium intake in the diet was found to associate with lower blood pressure levels [6].
Olive leaf (Olea europaea) extract is known in traditional medicine around the world to combat hypertension. The hypotensive action of olive extract is perhaps through a Ca2+ channel antagonistic effect [10].
Potassium supplementation was shown in clinical studies to reduce diastolic and systolic blood pressure in a dose-dependent manner primarily through a vasodilatory action. Fruits and vegetables are usually a good source of potassium in the diet [11].
Taurine is an amino acid that was shown in clinical trials to significantly lower diastolic and systolic blood pressure by enhancing endorphin production and lowering epinephrine serum levels [7].
Vitamin C reduces blood pressure through NO retention [7].
Vitamin D serum levels are found to be inversely correlated with the prevalence of hypertension in the population. Moreover, high serum levels of this vitamin correlate well with lower diastolic blood pressure readings [4].
Vitamin E increases the production of NO by potentiating the activity of nitric oxide synthase [7].
In summary, strong evidence in the literature supports the use of nutraceuticals in the management of hypertension. However, since uncontrolled hypertension can lead to major health complications and even to death, patients with hypertension must coordinate their use of nutraceuticals with their physicians to maximize the health benefits of these products.
https://www.cdc.gov/nchs/fastats/hypertension.htm
https://www.cdc.gov/bloodpressure/facts.htm
Shah SH, Stafford RS (2017) Current trends of hypertension treatment in the United States. Am J Hypertens
Ilic K, Obradovic N, Vujasinovic-Stupar N (2012) The Relationship Among Hypertension, Antihypertensive Medications, and Osteoporosis: A Narrative Review. Calcified Tissue International 92: 217-227.
Chen ZY, Peng C, Jiao R, Wong YM, Yang N (2009) Anti-hypertensive nutraceuticals and functional foods. J Agric Food Chem 57: 4485-4499.
Turner JM, Spatz ES (2016) Nutritional supplements for the treatment of hypertension: A practical guide for clinicians. Curr Cardiol Rep 18: 126
Khosh F, Khosh M (2001) Natural approach to hypertension. Alter Med Rev 6: 590-600.
Tashakori-Sabzevar F, Razavi BM, Imenshahidi M, Daneshmandi M, Fatehi H, et al. (2016) Evaluation of mechanism for antihypertensive and vasorelaxant effects of hexanic and hydroalcoholic extracts of celery seed in normotensive and hypertensive rats. Revista Brasileira de Farmacognosia 26: 619-626.
Walker AF, Marakis G, Simpson E, Hope JL, Robinson PA, et al. (2006) Hypotensive effects of hawthorn for patients with diabetes taking prescription drugs: a randomized controlled trial. Br J Gen Pract 56: 437-443.
Ali Hashmi M, Khan A, Hanif M, Farooq U, Perveen S (2015) Traditional Uses, Phytochemistry, and Pharmacology of Olea europaea (Olive). Evid Based Complement Alternat Med pp: 1-29.
Houston MC (2011) The Importance of Potassium in Managing Hypertension. Curr Hypertens Rep 13: 309-317
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Melbourne Rally – City Square
2014, Бер 5 | General
On March 4 in Melbourne we met again to pray for and to support Ukraine. While we always pray for Ukraine, it looks like we will need to publicly support Ukraine for a long time yet.
Ukraine needs God's blessing. It needs the support and understanding of Australia. It needs the support of all nations and people of goodwill in this world.
There are a few things we should be clear about with the situation in Crimea.
First of all, it has nothing to do with God. God does not stand for tyranny, invasion of foreign lands, the oppression of people, and putting the interest of certain people above the interest of others.
The situation has nothing to do with the church. Parts of Putin's own church are condemning this as a shameful act of aggression and are calling on him to stop and to remember what he may have learnt in his own religious education.
But as head of the KGB in the old Soviet Union, he worked hard to suppress churches and religious freedom. Members of the Australian Russian community are offering their support to Ukrainians and are expressing their disgust at Putin's actions.
This situation has nothing to do with international law or justice or democracy. On the contrary, it is being condemned as being illegal, immoral, and contrary to the behaviour of any civilized government.
What this invasion of Crimea is about has unfortunately been seen too often in the recent history in our world.
In 1938 Hitler invaded Czechoslovakia because there was a sizeable German population there. It happened in the former Yugoslavia. It happened in Georgia. It has happened again as we stand here.
Ukraine is a long suffering and often oppressed nation where its language, faith, culture, and identity are always under attack. We pray for a world where we all can tolerate each other and learn to live in peace.
There was already too much blood shed in Ukraine. The blood shed has stopped and no Ukrainians are shooting or attacking other people. This means that Ukrainians are God fearing, peace loving people and not fascists as political spin doctors are insinuating.
When Ukrainians stand up for their democratic rights they are called dangerous fascists, whereas the invaders insist on calling themselves heroes and saviours with a God given right to oppress and suppress anyone of their choice.
There are Ukrainians and Russians and people of other nationalities in most countries of the world. We must pray and work together to live in harmony, and not count on force and occupation to solve our problems and to take care of one ethnic group at the cost of all other groups who are present.
We believe there is enough of God's grace and strength in us to solve our problems without having to resort to occupation and dominance and the favouritism of one ethnic group over others.
Let us prayer that we may recognize the fact that we are all God's children and that we have the talents and strength within ourselves to solve our problems.
God Bless Ukraine!
Bishop Peter Stasiuk
Попередній Mnohaya Lita! Fr. Andriy and Olesia
Наступний UCWLA – UKRAINIAN CATHOLIC WOMEN'S LEAGUE AUSTRALIA
The World did not end – not yet! Article by Bishop Peter Stasiuk
Релігійна освіта. Що таке Церква?
Більшість вірить в загробне життя
Father Peter Struk is the new cathedral administrator
9 Вересня, 2013


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National Real Estate News
Hines, Equity Office Look To Crack The Co-Working Code
National Office View count:
December 14, 2017 Cameron Sperance, Bisnow Boston
Courtesy of Silva Brand
An interior of a WeWork office
Two of the largest U.S. office owners are recognizing the popularity of co-working spaces and looking to provide these flexible workspaces on their own. But they first must gain an understanding of the business model.
Equity Office and Hines have both issued requests for proposals in pursuit of business partners to gain knowledge of co-working spaces like WeWork, Reuters reports. The move comes in response to the growth of co-working firms, which are increasingly signing large corporate clients that traditional landlords would normally expect to sign for permanent workspace.
Green Street estimates co-working is 50% more profitable than traditional office leases, but only when operated by a seasoned provider. The analysis firm advised against office landlords building the model themselves.
"Significant scale, know-how and brand awareness would be required to operate profitably, and providers like WeWork are already miles ahead on all of the above," Green Street wrote in a report.
When Amazon expanded its Greater Boston presence, it did so by opening in a WeWork in the city's Back Bay neighborhood, making the co-working company both a tenant and a competitor to its landlord. Amazon did the same in 2 Herald Square in Manhattan, taking a full 122K SF WeWork space in a 354K SF building owned by Sitt Asset Management.
Manhattan has become a pinnacle market for co-working due to its building boom, young workforce and job surge. WeWork bought Lord & Taylor's 103-year-old flagship building on Fifth Avenue for $850M in October. The 650K SF building will be the company's headquarters after extensive renovations.
The deal also included an agreement for the company to open locations at Lord & Taylor parent company Hudson Bay Cos.' stores in Toronto and Vancouver, Canada, and Frankfurt, Germany.
Traditional landlords who have been focused more on asset value than tenant needs are now looking to change that to court a younger workforce that will eventually make office space decisions. RXR Realty is partnering with Convene, an on-demand provider of meeting space, on space at its 26-story office building at 530 Fifth Ave. in Manhattan.
Equity Office's RFP was largely inspired by the company looking to find a way to make its 1.3M SF Howard Hughes office complex in Los Angeles more attractive to tenants, according to Blackstone Group (Equity Office's parent company) Head of U.S. Asset Management Rob Harper. He told Reuters he expects responses to the RFP within days.
Related Topics: Hines, Equity Office, WeWork, Co-working
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"Remove the Risk" to raise awareness about proper disposal of prescription opioids The U.S. Food and Drug Administration today announced. . .
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Watch Jessie's Dad
This sobering documentary follows one heartbroken father's journey across the United States as he campaigns to institute harsher penalties for sex offenders. Florida truck driver Mark Lunsford lived a quiet life with his parents and nine-year-old daughter, Jessica, until February 24, 2005. That night, neighbor John Couey, a man with an extensive criminal record that included a conviction for indecent exposure, abducted Jessica from her bedroom. Her body was discovered in March of that year, buried in a shallow grave. Since that time, her father has made it his mission to fight for tougher sentences for sex offenders.
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Jessie's Dad
Jessie's Dad is a 2011 documentary with a runtime of 50 minutes. It has received mostly positive reviews from critics and viewers, who have given it an IMDb score of 7.2.
Where to Watch Jessie's Dad
Jessie's Dad is available to watch free on Pluto TV and Tubi TV. It's also available to stream, download, buy and rent on demand at Amazon Prime, Amazon, Apple TV, Google Play and YouTube VOD. Some platforms allow you to rent Jessie's Dad for a limited time or purchase the movie and download it to your device.
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Back in January I was chatting with an atheist who told me he believed religion promotes violence and hatred. I staunchly disagreed as it related to Christianity. He asked me, then, to explain the difference between Christianity and ISIS. I was initially taken aback by his question because, in my mind, he was making such a drastic comparison. Then I realized he was basing it on his belief that Christians and ISIS worship the same God. But my response was simple: Jesus does not call Christians to kill anyone in the name of God, but ISIS will kill in the name of theirs. Their god is not ours.
The God we worship does NOT exact condemnation through Christ Jesus (John 3:17). He instead offers grace so that those who are in sin have the opportunity to repent and be saved (John 8:10-11). We don't get to condemn someone - meaning, exact eternal judgment - because we consider them a sinner. That's not what our faith teachers. That is not of Christ.
I don't know if the atheist gentleman fully grasped what I was saying, but God spoke to my heart during that conversation. He would later put it to me simply: Christians aren't called to kill in God's name, but we she should be prepared to die in it. What this means is we must be prepared to face persecution for our beliefs, even if said persecution involves our death at the hands of those who strongly disagree with us. But WE don't get to lay a finger on anyone! Seriously, if we can't even slap someone back after slapping us, why in the world would anyone think Christians are cleared to kill in the name of God? We're too busy turning the other cheek (Matthew 5:39) and forgiving our brother 70 times seven (Matthew 18:21-22). But that's what we're called to do.
Another thing we're called to do, and what brings me to the point of this post, is to not judge WHY tragedy strikes certain individuals.
Now, I've not seen this for myself, but social media claims some Christians are saying some pretty insensitive things regarding why 50 people had to die and 53 were injured in an Orlando nightclub this past Sunday. If such insensitivity has occurred among our brethren, I am compelled to offer the following correction in love (and if you know a professed Christian who has been insensitive to this tragedy, please share this post with them).
Lovelies (brothers and sisters in the Faith), Jesus DOES NOT call us to judge WHY someone is stricken by tragedy. We don't get to say, "God did this because they were sinful people" or "they died this way because their sin was so great." That's self-righteousness at its worse. In case we all forgot, we're all sinners. We, as Christians, may be sinners saved by Grace, but we have the propensity to sin just like anyone else…we can live righteously one day and fall the next. And even before we were saved, we were most likely out in the world doing whatever we wanted with whomever we wanted (some of us still are – but that's another post). I know I was a fornicator, enjoyed going to nightclubs and even tried to dabble in mixed drinks (never quite mastered drinking, though...too much of a lightweight). I'm sure many of you have a similar testimony. So do you suppose YOU deserved to be shot up in a club before you made your way to God to repent?
As tempting as it is to want to explain why something happens, truth is most of us DON'T REALLY KNOW! But one thing Jesus DOES tell us all to do when tragedy strikes is to examine OURSELVES. We are supposed to say, "What if that were me in that situation" and then determine where WE stand with God. He tells us to think about where OUR soul would end up if OUR lives were cut short today. And THAT is why preaching the Gospel is so imperative - to ensure a place with God AFTER death. That is why WE must be ready to preach the Gospel in season and out of season (2 Timothy 4:2) - because most don't know when it will be their last day among the living.
If you never knew this, I urge you to read Luke 13:1-5. In this passage, Jesus is speaking to the Pharisee and Scribes who questioned Jesus about the tragic deaths of two groups of people who were known to be sinners (it was their goal to equate tragedy with sinfulness). One was a group of Galileans who engaged in some form of idol worship. The text does not detail exactly how they died, but it is apparent it was violent. The next group was a group of 18 people who died by being crushed by a tower. The text doesn't detail their sin, but Jesus confirms they were indeed sinners. Yet, His point was how someone dies does not allude to their level of sinfulness or righteousness. We don't get to say, "yeah, they were DEFINITELY sinners because they were crushed by a building!" versus "She must have been a good person because she died in her sleep." The lesson here is EVERYONE is going to die someday - even you! But the hope is that we do not perish. So our focus should be: Have I repented to ensure my own salvation? Have I got my own house in order? Do I truly know Jesus or am I just going to church and professing to be Christian to check a box? Have I been born again? These are the questions we should be prompted to ask ourselves when we take note of sudden and tragic events.
Life can end in a SNAP and the ending can come at an inopportune time. It's not about HOW or WHEN someone dies that determines whether they were saved/unsaved or righteous or unrighteous. Christians, to this day, are beheaded in certain parts of the world like it's a sport...we've seen some our brothers and sisters killed in their place of worship....some have even died horrendous deaths WHILE preaching and praying (Did we forget how APOSTLE Stephen was stoned to death? Acts: 7:54 – 8:3). Even our Lord and Savior, Jesus Christ was CRUCIFIED!
My loves, let's mature and focus less on WHY or HOW someone died and more on preparing ourselves and others for life with Christ after death. Let's love God, love one another and love the world enough to keep sharing the Gospel (Good News) so that those who desire to may repent and be saved. Moreover, let us man/woman up to be so bold in THIS love that we are prepared to die for it.
Prayer: God, please forgive us for speaking on things we don't truly understand and speaking out of turn. I thank you for the lessons of our Savior and Your Word, which correct us when our flesh gets in the way. I ask that you humble us to continue to demonstrate love and compassion to one another and in a way that is most appropriate for the situation and not what we assume. I ask that no matter how strong the rejection and persecution that we know will come, that we continue loving all for your sake until the end. Lord, let us be bold in this love so that all who will be saved are saved. Give us a clean heart, Lord. Purify us, Father. And allow us to walk in your Spirit as we preach, teach and in any way called to share your Truths with gentleness and patience, and correct in Love. Father, I also ask for you to show yourself strong in Orlando and throughout the United States. Give your peace to those affected by Sunday's shooting and allow your Spirit to be clearly seen in those who will work to provide aid and support. Finally, God, for anyone who seeks you as a result of this tragic event, may they find you, waiting with open and loving arms. You are always pleased when your sons and daughters return home. May our hearts be filled with just as much joy when the lost are found. In Christ Jesus' name, Amen.


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Others jeered at Booker for "wanting to redistribute wealth." However, Booker's desire to continue breakfast and lunch programs in order to prepare students to learn is a plea for equal opportunity. Does it make sense that children should be deprived of basic nourishment because their parents are poor, especially when it is the government's duty to educate our children? For Booker, educating kids is only possible when they are nutritionally ready to learn. But is this approach too paternalistic?
No. Instead of speculating about the matter, thankfully we have science. We know that sound nutrition including healthy fats, protein, carbohydrates, vitamins and minerals, and water is foundational to a student's learning. Going to school and expecting improvements in learning without breakfast and lunch, day after day, is like going to football practice without a helmet and shoulder pads: it cannot be done. This is not anyone's opinion, this is science.
Mayor Cory Booker's challenge comes as a continuation of an effort to highlight America's systematic failings. In 1999, Booker launched a 10 day hunger strike. Booker lived in a tent in front of Newark's worst housing projects in protest against the city government's apparent negligence.
Booker's feats are part of a greater effort to expose the reality of America that is often forgotten and looked past. An America where in no state is minimum wage sufficient to afford rent on an apartment. An America where poverty is at its highest level in over 40 years. An America where 1 in 6 U.S. citizens are hungry. An America where annual private college tuition can easily top $55,000, when median household income is less than $52,000.
Booker's actions serve to exemplify the disturbing realities many Americans face — realities neglected in the media, and perhaps more frighteningly, the recent election cycle. It is neither profitable nor glamorous to talk about this version of America that continues to undermine the so-called American Dream.
But rather than allocating blame and pointing fingers, slinging mud and demonizing political opponents, digging in heels and playing party politics, we must stand. We must stand for an America where the American Dream is real, not just a fairy tale. We must stand for an America where your status in society is not based off the family you were born into. We must stand for self-determination, the ability of every individual to pursue a decent life. This ideal of America will not come through overlooking the massive and ever-growing problem of poverty.
If we do not pay Cory Booker the attention he deserves, the subversion of America will continue to expand. Mayor Booker should be admired for his integrity in looking out for the future of America.


As the days for the fourth edition of Pakistan Super League are coming close, the excitement is increasing as well. Teams are busy launching their kits, anthems, and merchandise before all the action begins. In an event today, Quetta Gladiators also revealed official kit for 2019 along with their official food partner for PSL 4.
The recent addition in the list of the launches is the launch of Quetta Gladiators official kit. The Quetta warriors will be seen wearing the purple jersey throughout the season. The shirts are not just well designed but are also an example of what the team stands by i.e. glory and undying passion.
Team management revealed the kit through a tweet.
For what is a warrior without the shiny Armour, the embodiment of glory and undying passion.
In the event, along with their official jersey for this season, QG also announced their food partner which is KFC.
People on Twitter loved the design of the new kit, thousands of fans are already eager to buy it and support their favorite team of PSL. From the color combination to the overall look, everything was appreciated by the Twitterati.
Quetta Gladiators haven't made any major changes to the kit and have stuck to the old combination of purple and gold, the only change is the emergence of the extraordinary amount of logos which is a little annoying too.
What do you think about the new kit? Let us know in the comments.
For more updates and news on Pakistan Super League, keep visiting Cricket Howzat.


1/2 yard of cotton monks cloth with SERGED EDGES. It will arrive ready to begin your next rug hooking project. Three sides of this piece are serged. The 4th side is a woven selvage edge.
This backing fabric is used for hooking rugs. It is 100% cotton and measures approximately 29"x 36". The thread count per inch is 12 x 12. It is great for hooking with all cuts of wool, from fine to primitive cuts. A white thread runs about 2" apart along the length and helps with drawing designs on the straight of grain.
Cotton monks cloth is strong and durable and is a sure foundation for your hooked rugs. It is loosely woven and therefore the edges need to be finished or it will ravel away as you are hooking on it. So for those of you who don't sew, or don't have time to finish the edges, this is a great option.
To see other sizes of monks cloth and to see primitive linen backing, see the Hooking Supplies Section.
Designs In Wool is a smoke-free, pet-free environment.
Many thanks for the fast shipping and top quality monks cloth, Mary!
Mary was very kind, responded to my message and questions quickly. Fast shipping too! Thank you!


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Examples
========

The articles in this section deal with full examples including downloadable config.yml files.

.. toctree::
   samplepokemoncategory
   samplecustomtextures
   samplesmallpets
   sampleinventories
   samplesellingeffects
   samplepvppets
   samplehidingguiitems
   samplealwayswearingai

redpajama_set_name: RedPajamaGithub


The painting was signed by the artist-academic ("GIORGIO ARETIN FACIEBAT"), who also mentioned it in his "Ricordanze". He had promised to finish the piece by 1534, but more than ten years went by from when he started it to when it was completed, making it contemporary with Pisa's Sacred Conversation, lost in 1595. The painting was broadly structured between 1533 and 1538, evidence of which can be seen in the strong influence of Salviati and allusions to Michelangelo's Pieta. The dark background seems to date to the final stage of painting in roughly 1544, the almost complete lack of space is inline with certain anti-Renaissance tendencies of the Tuscan school at that time. The altarpiece remained in the Sant'Agostino church until 1661, when it was bought by Camillo Pamphilj for 150 scudi, after having financed some work on the church.


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Q: Why is my date input field in AngularJS throwing type error? The error occurs when I display the populated, editable form to the user (not when a user enters in data and submits).  The data is coming from MySQL over REST/JSON in the service shown below:
HTML:
<input class="form-control" type="date" name="dateInput" id="dateOfBirth"
                   ng-model="user.dateOfBirth">

CCONTROLLER:
.controller('EditCtrl', function ($scope, $routeParams, UserDetail, $window) {
        $scope.user = UserDetail.find({}, {'id': $routeParams.id});
}

SERVICE:
service.factory('UserDetail', function ($resource) {

    return $resource(
        'http://localhost:8080/ClearsoftDemoBackend/webresources/clearsoft.demo.users/:id',
        {id: '@id'},
    {
    find: {method: 'GET'},

    });
});

ERROR:
Error: [ngModel:datefmt] Expected 2010-05-13T00:00:00-04:00 to be a date

A: Its because that is not a valid date according to Angular. Check out the doc on input[date] for their note on date validation. For it to be a date it should be in the format of YYYY-MM-DD.

A: AngularJS 1.3 adds to input [date | datetime-local ] fields a new formatter/parser that checks that the model is a Date Object and throw the datefmt exception.
if (value && !isDate(value)) {
    throw $ngModelMinErr('datefmt', 'Expected `{0}` to be a date', value);

This issue is not present at previos versions and I suggest get in consideration on upgrade to avoid big nightmares.
A workaroud is to reset default formatters/parser with a custom dateFormat directive and use momentjs to format,parse strings to Date.
define(['directives/directives','momentjs'], function(directives,momentjs) {
directives.directive('dateFormat', function() {
      return {
        require: 'ngModel',
        link: function(scope, element, attr, ngModelCtrl) {
          var format=attr.dateFormat;
          //Angular 1.3 insert a formater that force to set model to date object, otherwise throw exception.
          //Reset default angular formatters/parsers
          ngModelCtrl.$formatters.length=0;
          ngModelCtrl.$parsers.length=0;

          ngModelCtrl.$formatters.push(function(valueFromModel) {
             //return how data will be shown in input
              if(valueFromModel){
                 // For momentjs > 2.9 moment global va is not defined use momentjs instead of moment.
                  return moment(valueFromModel).format(format);
              }
              else
                  return null;
          });
          ngModelCtrl.$parsers.push(function(valueFromInput) {
              if(valueFromInput){
                  //For momentjs > 2.9 moment global va is not defined use momentjs instead of moment.
                  return moment(valueFromInput,format).toDate();
              }
              else
                  return null;
          });
        }
      };
    });
});

UPDATE With momentjs > 2.9 take in consideration that the moment global var are not defined.
2.9 "Deprecation warning: Accessing Moment through the global scope is deprecated, and will be removed in an upcoming release."

With AMD need use momentjs instead of moment. i.e:
return momentjs(valueFromModel).format(format);

A: In your api
$date = date("Y-m-d");
$new_date = date("c",strtotime($date));
echo json_encode(array("date"=>$new_date));

In your controller
/* var date
* this is value from your api
*/
$scope.date = new Date(date);

A: For date value in an array one can use this as:
    var dates = [
      { id: "1" , date: "2015-04-20T11:24:20.882Z"},
      { id: "2" , date: "2015-05-20T11:24:20.882Z"},
      { id: "3" , date: "2015-06-20T11:24:20.882Z"},
    ];

      function dateStringToObject (data) {
        for(var i=0; i < data.length; i++ ){
          data[i].date = new Date(data[i].date);
          }

        return data;
      }

   dateStringToObject(dates);

A: Basically its not about the format, it want a valid new Date() object in ISO format ,so whatever you get response ,just do a new Date and angular will be happy , i got this when i parsed the exception message caused by angular
https://docs.angularjs.org/error/ngModel/datefmt?p0=2015-11-24

redpajama_set_name: RedPajamaStackExchange


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therestlessnest2019-11-07T12:08:22-08:00Categories: featured posts, memoir, midlife, travel, Uncategorized, war|Tags: Hanoi, laughing yoga, Saudade, Vietnam|
The day I left Vietnam, I laughed and laughed. I had not expected to. I woke up feeling sad about having to leave after only two weeks: far too short a time for my first visit to this captivating country. But my travel-mates—Anne and Lindsay, close friends I have known since freshman year of college—and I had hatched a plan for our final morning: we would get up at 5:30, throw on clothes, and walk over to Hoan Kiem Lake, a short stroll from our hotel in Hanoi. Anne had done this the day before. "Trust me," she said. "You won't believe it." As we neared the lakeshore, the streets filled with people, many in athletic outfits, walking, jogging, bicycling. They, and we, were reveling in the relative cool of the dawn air: by 9 am, we all knew the temperature would be in the 90s and indescribably humid. When we got to the lake, we saw exercise groups of every possible type, all of them already in full swing: Tai Chi, yoga, Zumba, old-school aerobics, hip-hop dancing, ballroom dancing. Across the street, a few dozen people had gathered with the apparent purpose of laughing their heads off. The laughing people motioned to us to join them. Why not? "Ha, ha, HEE," we all shouted in unison, as we stretched and moved in gentle yoga-like ways, following the leader as best we could; breaking into more free-form laughter as we formed into a shoulder-massaging congo line; and then making different laughing noises as we clustered in [...]
No Ordinary Time
therestlessnest2019-11-07T14:53:51-08:00Categories: feminism, human rights, midlife, politics, war, women's rights|Tags: Doris Kearns Goodwin, Eleanor Roosevelt, FDR, justice, military, No Ordinary Time, Scaramucci, transgender|
"This is no ordinary time," Eleanor Roosevelt told the Democratic Convention of 1940, "and no time for weighing anything except what we can best do for the country as a whole." No Ordinary Time: Doris Kearns Goodwin chose that phrase to be the title of her 1994 book, subtitled Franklin and Eleanor Roosevelt: The Home Front in World War II. Eleanor's words have a different ring in 2017, don't they? This is a year that feels like no ordinary time in ways that she would likely find—dismaying. Discouraging. Despicable. Or maybe not: because Eleanor knew, almost better than anyone in her day, that every step forward toward justice for all was inevitably followed by an ugly backlash. She and her husband regularly received vicious hate-mail from segregationists, sexists, and xenophobes of all kinds. For two months, No Ordinary Time sat on my coffee table, all 636 pages of it (759, counting the end-notes and index). My father had dropped it off. He was sure I would find it as compelling as he had. I resisted. It looked so—daunting. But it only took a page or two for Goodwin's writing to hook me and hold me. This is a book that is both a detail-rich history lesson and a gripping summer page-turner. Reading it, I realized just how little I know about the history of World War II and about the president and first lady who steered us through those years of drama and tragedy. It is not a hagiography: Goodwin calls out, in particular, the [...]
Healing is a risky business
therestlessnest2019-11-07T15:39:11-08:00Categories: arts, brain, faith and doubt, feminism, film, health & medicine, human rights, journalism, war, women's rights, writing|Tags: Beirut, Dana Robbins, Garrison Keillor, Islamic State, Mary Mapes, Moon Pie Press, Spotlight movie, The Writer's Almanic, Truth movie|
Healing is a risky business. Any poet or journalist could tell you that. It's risky, because it has to start with truth telling, and when we're wounded, the truth is not often what we want to hear. For me, last week started with the peak experience of hearing Gloria Steinem rock Seattle's Benaroya Hall, and it ended (or so I thought) with the peak experience of hearing Garrison Keillor read a poem written by my college friend, Dana Robbins, to a national radio audience. Gloria and Dana: two risk-takers, two truth-tellers. You know Gloria, so I'll tell you a bit about Dana: she survived a stroke at 23 and a number of other nightmares and heartbreaks, which she writes about in her first published book of poems, The Left Side of my Life (Moon Pie Press, 2015), in which you will also find poignant poems about motherhood and about her joyful second marriage. It was thrilling to me to at last hold a book of her poems in my hand AND hear her on the radio in the same week. But last week didn't end there. Because that was Before Paris. For the Islamic State terrorists, the bloody attacks on Paris that killed 129 people were the grand finale of a two-week horror show that included claiming responsibility for the October 31 plane crash in Egypt that killed 224 people and bombings in Beirut that killed 43 and in Baghad that killed at least 26. For those of us who are slow to wake up to [...]
Polska, 1994
therestlessnest2019-11-13T16:12:33-08:00Categories: arts, human rights, travel, war, writing|Tags: Goddard MFA, Isla McKetta, novel writing, Poland, Rebecca Bridge, Ukraine, writing prompts|
Restless Nest readers, today we are toasting my friend and Goddard MFA classmate Isla McKetta, whose novel, Polska, 1994, has just been published by Editions Checkpointed, the French publisher known for the literature of conflict. Wow. I asked Isla a few questions about how it happened and here's what she had to say: 1. You balanced writing a novel/earning an MFA with a full-time job. How? And why? What drove you? When I first decided to apply for MFA programs—when I committed to the idea of myself as a writer—I hadn't worked in almost two years. I'd left my job to take care of my mom through a couple of surgeries, and that journey home forced me to face some childhood trauma from her initial battle with cancer. The whole thing left me in a state of depression that eventually became a spur to examine what I wanted in life. I realized that what made me feel happiest and most fulfilled is when I am creating art, and words are my go-to medium. I started applying to graduate programs and jobs at the same time. I'm one of those people who's doing everything all at once or nothing at all, and I think I'd built up a lot of energy during that down time so working while going to school felt like a good way to throw myself back into living. Plus, the more I wrote, the more the act of writing energized me. You know how intense the MFA program can be, and by the [...]
The Intangible Zone
therestlessnest2013-11-25T14:59:18-08:00Categories: human rights, travel, war|Tags: asentamientos humanos, Manchay, Peru, Shining Path|
High on a dusty hill outside Lima, a sign rippled in the wind: "Zona Intangible," it said. In-tan-gi-blé, in Spanish, but the literal meaning is the same: untouchable. The Untouchable Zone. For a minute, I thought it might mean there were dangerous chemicals buried there, or live electrical wires, or something else it would be very dangerous to touch. But no: what the sign meant was: don't try to build your house here. Just a few hundred yards downhill, we watched a few family groups hacking level spaces in the soft sand. One family had some pre-nailed walls stacked nearby: their future one-room home, at the ready. Another young couple let their two-year-old son take a turn with the shovel. This is the uphill edge of Manchay, a sprawling community of about 100,000 people on the outskirts of Lima. It is one of many asentamientos humanos, human settlements, that have sprung up around Peru's capital city, where one out of every three of the country's 30 million people now live. On a first visit to Manchay, it is very hard to imagine why anyone would want to live in this place. Most of the roads are unpaved, churning up constant clouds of dust, which coats everything, including the occasional brave flower garden or struggling tree. And yet: there is another kind of Zona Intangible here. Manchay was founded by people whose driving desire was to live in peace. Most of them came from a landscape that could not have been more different from this one: the [...]
A Girl, Alone
therestlessnest2013-05-14T11:44:53-07:00Categories: war, women's rights|Tags: Amanda Knox, Chris Cuomo, rape, sexism, sexual assault, women in the military|
If he's still alive, he's old and probably fat by now. That guy I try never to think about. His face has faded, but I remember him as a little doughy. That guy who did to me what I could not bring myself to call rape at the time. I was traveling alone. I'd missed the overnight train from Geneva to Paris. He offered me a spare bedroom; swore I'd be perfectly safe. To my 19-year-old eyes, he looked trustworthy, this 30-something pilot in an expensive trenchcoat. So surely it was my fault, right? When I woke up in the wee hours of the morning and he was on top of me? Judge me if you will. Call me stupid and naïve; that much is fair. But who ever judged him? No one. Yet I knew I didn't have a story to tell a Swiss police officer. So I got on the train and went back to my study-abroad dorm room in England, feeling a little wiser and a lot older. When I got back to the States, I wrote a short story about it in which I tried to be very Hemingway-esque, starkly describing what happened but leaving out all details about how I felt. Because of course I didn't know I felt. Or rather, I felt so many different feelings I didn't know which was the real one: shame? Anger? Sadness? Outrage? They were all real and they have all been flooding back to me this month, which has not been a good one [...]
therestlessnest2013-01-29T15:04:12-08:00Categories: politics, Uncategorized, war, women's rights|Tags: draft, Gail Collins, Karl Marlantes, Obama, Roe v Wade, women in combat, women in the military|
I claim I want to better understand war. But my gut reaction to the news about women being allowed to serve in combat positions? Queasy. As if what the headlines are shouting is: "Hooray! Women will now be allowed to do the most dangerous, spiritually challenging, morally ambiguous dirty work on the planet!" New York Times columnist Gail Collins set me straight, reminding me that "They killed the Equal Rights Amendment to keep this from happening, but, yet, here we are. And about time." Collins goes on to recall the words of retired Air Force Brigadier General Wilma Vaught, who once told her: "I think people have come to the sensible conclusion that you can't say a woman's life is more valuable than a man's life." The logic is clear: if we invest our nation's security in professional warriors and if we believe women deserve equal access to all career paths, then women who make the personally huge commitment to serve in the United Sates Armed Forces must not be barred, on the basis of gender, from combat roles. So why my retrograde queasiness? Because, like any pacifist, I find it so difficult to turn my thoughts to combat at all, no matter what the context. But—as I learned from Karl Marlantes' book, What it is Like to Go to War (see last week's post)—I know turning our backs on war is not the answer. Especially the wars we support with our tax dollars. It has been 40 years this month since we ended the draft. [...]
My Viet Nam
therestlessnest2013-01-22T20:30:14-08:00Categories: politics, war|Tags: current-events, draft, Iraq War, Marlantes, peace, Selective Service, Viet Nam War|
Forty years ago this week, the Selective Service announced there would be no further draft calls. My brother, then a college student, had a dangerously low draft number. He and his peers hated and protested the Viet Nam war with a fervor that frightened me as much as the TV images of the war itself. But we who were young children in the 1960s grew up hating the war in a different way. We hated it the way children hate watching their parents fight. We hated it selfishly, because it was robbing our families, and therefore us, of playfulness, joy, innocence. Our older brothers and sisters had fifties childhoods; all Kick the Can and Leave it to Beaver. We tried to. But we'd seen things on television the Beav would never have been forced to see: kids our age aflame in napalm. Soldiers bleeding and screaming. By the time we were of protesting age, we were sick of it all: war and protest; fighting and shouting and political posturing. We turned away from community, from engagement. Remember the "me generation?" That was us. Isolationist, pacifist, devotees of meditation and marijuana; avoiders of meetings and causes. Most of us came out of our shells when we became parents. Having children of our own gave war a whole new meaning. When the United States went to war against Iraq in 1991, my husband and I carried our baby daughter in a march for peace on Capitol Hill. It was the first time I'd ever marched for anything. But [...]


Find project reports relating to the composition of food, including reports about the presence of natural toxins, allergens, and contaminants, and their impact on human health and nutrition.
As one part of its Nutrition Strategy 2009-12, the New Zealand Food Safety Authority (NZFSA) has identified sodium reduction as a priority new work programme. The Science Group of NZFSA commissioned the University of Otago (the 'authors') to write a discussion document that provided a review of information on sodium and its effects on food safety and human health.
Science research on Vitamin K in milk.
This Risk Profile addresses the risk from exposure to caffeine from energy drinks and energy shots available in New Zealand against a background dietary exposure from naturally occurring caffeine in foods and beverages and kola type soft drinks.
Polycyclic aromatic hydrocarbons (PAH) are a large group of compounds made up of two or more fused benzene rings. They are primarily formed by incomplete combustion or pyrolysis of organic matter and during various industrial processes. Consequently, they are found in automobile exhaust, smoke from fires or cigarettes and as a component of air pollution. PAHs generally occur in complex mixtures which may consist of hundreds of compounds.
Monosodium glutamate (MSG) is the sodium salt of the non-essential amino acid glutamic acid. Glutamic acid is one of the most abundant amino acids in human foods. When glutamate is present in a free form, not as a component of proteins or peptides, it has a flavour-enhancing effect and for this reason it is added to foods as its purified monosodium salt.
Glucosinolates are a family of about 120 plant compounds. They are modified amino acids, carrying an S-glucose functional group and a variety of different side chains. The parent compounds can be broken down by a plant enzyme, myrosinase, which is liberated for reaction through processing of the plant tissue (e.g. cutting, cooking or freezing).
Cyanogenic glycosides or cyanoglycosides account for approximately 90% of the wider group of plant toxins known as cyanogens. The key characteristic of these toxins is cyanogenesis, the formation of free hydrogen cyanide, and is associated with cyanohydrins that have been stabilised by glycosylation (attachment of sugars) to form the cyanogenic glycosides.
Bisphenol A (BPA) is a chemical used primarily as a monomer in the production of polycarbonate plastics and epoxy resins. Polycarbonate plastics are rigid plastics sometimes used for food contact materials, including drink bottles. Epoxy resins are used for lining tin cans.
The aim of the project was to assess levels of vitamin C and zinc in a range of food types, and selenium in infant formulae; and to compare these to average levels claimed on product labels, and in the case of selenium in infant formula, to the mandatory minimum and maximum levels in the Standard 2.9.1 of the Food Standards Code. This information will assist in the development of food standards relating to nutrient fortification. The project follows similar projects assessing levels of folate and iron (2005) and vitamin A, vitamin D and calcium (2006).
fatty acid content to support decisions regarding labelling.
Cholecalciferol, or 'vitamin' D as it is commonly referred to, is a popular research topic.
While it has long been known that vitamin D deficiency causes rickets in children, there is now renewed interest in this pro-hormone as potential health roles for vitamin D increase, with a concomitant rise in prevalence estimates for insufficiency. An informed discussion on vitamin D by public health professionals is now especially relevant because of recent evidence that many New Zealanders have low vitamin D status (1, 2).
Vitamin D is an essential nutrient that can be synthesised in the body through exposure to sunlight or obtained through eating foods that are naturally good sources of Vitamin D. A deficiency of vitamin D can lead to rickets in children and osteomalacia (poor bone mineralisation) and osteoporosis (bone loss) in adults. Research suggests that vitamin D may also play a role in the prevention of certain cancers.


Abelha (Portuguese for "bee") is simple yet classy in its contemporary neutrals. This middle-weight towel features an exfoliating, honeycomb inspired waffle pattern along it's edge. As with all Abyss towels, it is woven of Extra Long Staple Egyptian Cotton and is colorfast and preshrunk.


text:
Züschen ist der Name folgender Orte:

 Züschen (Fritzlar), Stadtteil von Fritzlar
 Züschen (Winterberg), Stadtteil von Winterberg
Siehe auch:
Zischen
Zöschen


text:
Samsung Galaxy S11 might come with FaceID-like face unlock setup
Samsung is working on a new facial recognition system that will feature in the Galaxy S11 in 2020. According to a report by TechTastic, Samsung is actively working on a facial recognition system that could be as secure as FaceID on the iPhone 11 Pro.
Reference of the new facial recognition system was found in the beta version of OneUI 2.0. The Android 10 beta for the Galaxy S10 has references of the Face Service app for the Picasso, the codename for the Galaxy S11. This could mean that Samsung is exploring the idea of adding a new form of biometric security to make its smartphones safe and secure.
Samsung currently uses 2D facial recognition, which is less secure and can be easily fooled by showing a photograph of your face. Apple and Google, on the other hand, uses 3D facial recognition. Apple is using FaceID on its latest iPhones, which is 20 times more secure than Touch ID. The Pixel 4, too, offers a secure facial recognition system that uses an infrared sensor to project dots on your facial features to unlock the device.
The tech major was in the news recently for an unreliable fingerprint scanner on its flagship Galaxy S10 and Galaxy Note 10. Last month, The Sun ran a story about a British woman who discovered that anyone can unlock her Galaxy S10 smartphone. Samsung later apologized and released a software update to address a bug on the ultrasonic-based fingerprint scanner in the Galaxy S10 and Galaxy Note 10.
Samsung is projected to take the wraps off the Galaxy S11 and Galaxy S11+ sometime in February next year. Both smartphones are expected to feature edge to edge AMOLED screens, a 108MP camera, 5x optical zoom, Android 10, and a Snapdragon 865 processor. The company is also rumoured to launch the Galaxy Fold 2 with a clamshell form factor, which was teased at the company's developer conference in San Jose last week.
Posted by Sulochana at 12:55 PM


text:
Brexit POLL: Is Sadiq Khan right to call for closer ties to EU?
By dailysunpost_1rcpnd January 13, 2023 News No Comments2 Mins Read
London Mayor Sadiq Khan has slammed the Government's "denial" of the "immense damage" Brexit is causing Britain. During a government dinner at Mansion House on Thursday the Labour mayor argued the nation should shift from the current "unnecessarily hardline version" of Brexit and move towards greater alignment with Europe. But do you agree? Vote in our poll.
Mr Khan told City leaders: "I simply can't keep quiet about the immense damage Brexit is doing. Ministers seem to have developed selective amnesia when it comes to one of the root causes of our problems. Brexit can't be airbrushed out of history or the consequences wished away."
He also argued that Brexit has negatively affected the economy, with a reduction of GDP by 5.5 percent, but that issues must be addressed before it is too late.
READ MORE: Khan to urge UK to rejoin EU single market as 'Brexit not working'
He explained: "After two years of denial and avoidance, we must now confront the hard truth: Brexit isn't working. It's weakened our economy, fractured our union and diminished our reputation. But, crucially, not beyond repair.
"We need greater alignment with our European neighbours – a shift from this extreme, hard Brexit we have now to a workable version that serves our economy and people. That includes having a pragmatic debate about the benefits of being a part of the customs union and the single market."
In response, Prime Minister Rishi Sunak's official spokesman said: "The British people set out their view back in 2016 and the government is busy enacting."
So what do YOU think? Is Mr Khan right to call for closer ties to EU? Vote in our poll and leave your thoughts in the comment section below.


We hear of "control freaks," and exercising self-control, but what does this have to do with being a Christ-follower? Who's in control?
You, however, are not controlled by the sinful nature but are in the Spirit, if indeed the Spirit of God lives in you.
By the 8th chapter of Romans, Paul has spoken of a war within each believer, of two natures--the old dead self, and the newly-born follower of Christ. But with the Spirit of Christ growing in each of us, we no longer are controlled by our sinful nature, but now by the Spirit of Christ.
Today, your feelings may tell you otherwise, but your feelings are wrong. The Spirit of Christ is in control of each believer's life. Live today honoring the Spirit's leading, the Spirit's control of your life, and thrive.


Evening Felix , you're absolutely right you wouldn't know IG was on unless you turned on ABC Channel. Channel 9 has drunk too much sugar all day long they follow them about , it's the MM Fake pregnancy show . Think sensible & logical HM would not send a nearly 40 yr old first time mother on such a event scheduled tour like this one , hopping on planes & boats daily. Meeting ppl from all over the world in major Tourist designations the germs everywhere. A midwife just commented on Skips about going to Zika Islands saying she would loose her registration if see let her patients go , now she said she has patients saying if the duchess can go so can they , like she said Zika is major health problems for unborn. So obviously HM did not know until they landed here in Australia, timing suspicious again just like when she outed the Fling Oct 16 the day her Reitmans clothing line got launched, also MM mirror now merching maturity and babies clothing. If she is lying HM needs to annull this marriage on the grounds of Fraud of truth to the Monarchy UK & Commonwealth ppl end of story . Also her media friend Mio said she has consulted a Doctor and she was fit to travel , don't the BRF have a regular Obstetrics Dr , what MM to good for him? Again to much not adding up . Just had a $ 10 bet with a work colleague miscarriage announcement around PC 70 th , 14 Nov, I'll keep coming back to see if my intuition is right . Night.
hi QLD. Correct. The timing is way off and are lot of questions are raised over this by many which we all know that there is something off. Yesterday we got pics of her in black jeans wearing a belt and was totally flat aand today she looked like she was 6 months pregnant holding her belly as she walked around with Harry.
The media are banking on it. IG doesn't exist as you said Channel nine is following these 2 around. No news is stated about the games or them here in Melbourne. We have gone back to not nowing that they where here last week.
But I agree The Palace needs to step in because this is going to end them when it turns ugly. People will automatically jump on MM's side.
plus I hope you win the bet. Let's see if this rumour will come true and you can prove to your work colleague that you smelled a fake pregnancy from the beginning.