Tissue Doppler imaging (TDI) can be used to assess fetal cardiac function and it has been shown to detect changes associated with hypoxia in animal models. However, the analysis is cumbersome and time consuming. The main objective of this study was to evaluate the feasibility of a new algorithm developed for the automated analysis of color TDI velocity recordings of the fetal myocardium. Furthermore, we wanted to assess the effect of different sizes of region of interests (ROI) on the measurement of cardiac cycle time intervals and myocardial velocities at different gestations.
This study included analysis of 261 TDI velocity traces obtained from 17 fetal echocardiographic examinations performed longitudinally on five pregnant women. Cine-loops of fetal cardiac four chamber view were recorded with color overlay in TDI mode and stored for off-line analysis. ROIs of different sizes were placed at the level of the atrioventricular plane in the septum and in the right and left ventricular walls of the fetal heart. An automated algorithm was then used for the analysis of velocity traces.
Out of the total 261 velocity traces, it was possible to analyze 203 (78 %) traces with the automated algorithm. It was possible to analyze 93 % (81/87) of traces recorded from the right ventricular wall, 82 % (71/87) from the left ventricular wall and 59 % (51/87) from the septum. There was a trend towards decreasing myocardial velocities with increasing ROI length. However, the cardiac cycle time intervals were similar irrespective of which ROI size was used.
An automated analysis of color TDI fetal myocardial velocity traces seems feasible, especially for measuring cardiac cycle time intervals, and has the potential for clinical application.
Tissue Doppler imaging (TDI) is a technique that is used to evaluate the movements of the myocardial walls. In adults, it appears to facilitate the diagnosis of subclinical myocardial disease and helps in predicting the prognosis of major cardiac diseases, such as acute myocardial infarction [1–5]. The method has proven to be feasible in human fetuses [6, 7], and it has been tried for evaluating fetal cardiac function in various pregnancy complications, such as intrauterine growth restriction [8, 9], twin-to-twin transfusion syndrome  and gestational diabetes .
Studies on adults during hypoxia have found prolongation of ventricular isovolumic relaxation time measured by TDI . This concurs with studies on sheep fetuses indicating that hypoxemia/acidemia is associated with prolonged flow Doppler isovolumic contraction time . In an experimental fetal sheep model, prolongation of the pre- and post-ejection phases of the cardiac cycle during acute hypoxia/acidemia was demonstrated using color TDI . The analysis of color TDI velocity traces could hypothetically give early indications of fetal hypoxia, as myocardial dysfunction is often the consequence as the circulation tries to adapt to a diminished oxygen supply.
There are two main echocardiographic approaches to assess myocardial motion, i.e. spectral (pulsed wave) TDI and color TDI. In both techniques, the region of interest (ROI) is generally placed at the level of the atrioventricular plane (AV-plane) in order to assess the longitudinal motion executed by subendocardial longitudinal myocardial fibers that are considered to be most susceptible to hypoxia [15, 16]. High resolution imaging is required to detect subtle changes in myocardial motion during different phases of the cardiac cycle. Since color TDI does not use fast Fourier transformation and can display velocity information in real time, it is plausible to think that it should have a higher temporal resolution than the spectral TDI . Therefore, we hypothesized that color TDI is preferable for detecting changes associated with fetal hypoxia. However, acquisition and interpretation of color TDI in fetuses is associated with challenges related to fetal movements, high fetal heart rate and problems of defining time events in the cardiac cycle without a simultaneous ECG. Furthermore, the analysis is cumbersome and time consuming. The analysis includes image acquisition, transfer into other systems followed by visual identification and manual definition of cardiac cycle time events before quantitative information can be obtained. Since noninvasive recording of fetal ECG of adequate quality is not readily available, we designed a new method that enhances the information regarding myocardial velocity change over time. This allows for an automated analysis of myocardial velocities and a definition of cardiac cycle time intervals without concurrent ECG. This automated method of assessing cardiac cycle time intervals could potentially facilitate the application of color TDI as a tool for assessing fetal cardiac function.
To perform the automated analysis with this new method, well-defined velocity traces are required. Acceleration traces with distinct shifts that represent the changes in myocardial work can then be derived and used to define time intervals. The resolution of traces might be influenced by several factors including the size of the ROI, frame rate, size of the color box, sector width and line density. A larger ROI size has been shown to reduce the variability and diagnostic inconsistency in adults with dyssynchrony  and a smaller ROI size had a higher variance in measured parameters in a study on cats . Using a larger ROI is expected to have a smoothing effect and reduce the measured velocities. However, as the main intention is to develop a rapid simplified method to assess changes in cardiac cycle time intervals, such as pre- and post-ejection phases that could potentially indicate fetal hypoxemia/academia, a loss of velocity information might be acceptable.
Clinical application of TDI for assessing and monitoring fetal wellbeing could be simplified and improved by automation of image analysis. Thus, the main objective of this study was to evaluate the feasibility of a new algorithm developed for the automated analysis of color TDI velocity recordings of the fetal myocardium. Furthermore, we wanted to assess the effect of different ROI sizes on the measurement of cardiac cycle time intervals and myocardial velocities at different gestations.
This study included analysis of 261 TDI velocity traces obtained from 17 fetal echocardiographic examinations performed on five pregnant women with uncomplicated singleton pregnancies. These five women were randomly selected from a group of 120 women with uncomplicated pregnancies included in a larger longitudinal study investigating fetal cardiac function during 18–40 weeks of gestation. Ultrasound examinations were performed serially at approximately 4-weekly intervals by an experienced operator using a Vivid 7 Dimension ultrasound machine equipped with a M4S sector transducer with frequencies of 1.5–4.3 MHz (GE Vingmed Ultrasound AS, Horten, Norway.) Pregnancies were dated based on the measurement of biparietal diameter in the second trimester. The study was approved by the Regional Committee for Medical and Health Research Ethics – REK Nord (Ref.nr. 105/2008. Date of approval: 16.12.2008) and an informed written consent was obtained from all the participants.
At each examination, a four chamber view of the fetal heart with color overlay in TDI mode was obtained and cine loops of 5-10 consecutive cardiac cycles were recorded. The ultrasound beam was aligned parallel to the interventricular septum with an insonation angle close to zero (<10°). An attempt was made to keep the frame rate >180 frames/s. An off-line analysis was performed using quantitative analysis (Q-analysis) in EchoPAC (GE Vingmed Ultrasound AS, Horten, Norway.) Fixed ROIs of different sizes were placed at the level of the AV-plane in the septum and in the right and left ventricular wall of the fetal heart. ROIs were placed manually at the level of the AV-plane (Fig. 1). The width of the ROI was increased in order to fit the increasing thickness of the septum or the ventricular walls.
The material was divided into three gestational age (GA) groups: GA I (18-24 weeks), GA II (25–32 weeks) and GA III (33–41 weeks). The largest ROI widths of 2 mm, 3 mm and 4 mm were chosen for GA I, GA II and GA III, respectively as estimated to cover the entire thickness of the myocardium. The ROI length was increased in steps to cover different proportions of the ventricular length. The length of the septum was measured from the AV-plane to the apex in end-diastole and ROI sizes compared to this as an estimate of proportion of myocardial ventricular length occupied by each ROI size. The largest ROI length in this study was 4 mm, 6 mm and 8 mm in GA I, GA II and GA III respectively. A ROI of 2×2 mm was analyzed for all recordings to enable comparison of myocardial velocities between different ROI sizes.
The myocardial velocity traces were transferred to GHLab software (Gripping Heart AB, Stockholm, Sweden) for visual identification and manual definition of cardiac cycle time intervals [20–22]. GHLab is a software that utilizes shifts in acceleration to define time events according to the Dynamic Adaptive Piston Pump (DAPP) principle describing the heart as a mechanical pump controlled by its inflow . This method allows for identification of time intervals without a concurrent ECG signal. One representative cardiac cycle was chosen for the manual definition of acceleration shifts, subsequently generating six phases of the cardiac cycle: atrial contraction, pre-ejection, ventricular ejection, post-ejection, rapid filling and slow filling (Fig. 2). As the heart function, according to the DAPP principle, is initiated by the movement of the AV-piston (the AV-plane), the atrial contraction is considered as the starting point of the cardiac cycle. The terms pre- and post-ejection are used instead of isovolumic contraction and relaxation as they are defined by shifts in myocardial work rather than by the valve opening and closure.
The acceleration shifts were assessed by two investigators (LH and JJ) and the traces were divided into three categories depending on the degree of well-defined shifts. An acceleration score of 3 represents clear and well-defined shifts, a score of 2 less well-defined, often with a biphasic appearance, and a score of 1 with indistinct shifts, generally with a flat appearance (Fig. 3). An average score was calculated for the septum, right and left ventricular wall. The total number of optimal traces with an acceleration score of 3 for each ROI size was recorded as a measure of quality.
Information regarding peak myocardial velocities during early diastole (Em), atrial contraction (Am) and systole (Sm) were automatically extracted from the traces by the GHLab software as soon as the time intervals were defined. All measured velocity parameters were compared to the 2×2 mm ROI as the smallest ROI size is expected to record the highest velocities being closest to the AV-plane and averaging a smaller area. The differences in velocities and time intervals measured using different ROIs were calculated as the percent change in relation to the reference ROI of 2×2 mm.
A newly developed automatic algorithm was then used to analyze the original TDI velocity traces and obtain cardiac cycle time intervals using MATLAB (R2010a, MathWorks, MA, USA). The automated algorithm consists of approximately 100 pages of MATLAB code, encompasses four different filter settings and uses pattern recognition to detect time events.
In order to assess limitations, extended information was extracted from the DICOM files. For the evaluation of axial resolution the points/mm along the ultrasound beam was measured, for temporal resolution the frame rate and for the spatial resolution the line density was noted. The traces were smoothed by a three point moving average filter in EchoPAC.
Data analysis was performed using IBM SPSS Statistics for Windows, version 23.0 (IBM Corp., Armonk, N.Y., USA). Continuous variables are presented as mean ± SD or median (range) as appropriate. Categorical variables are presented as (n %).
The mean age of the pregnant women was 29 ± 4.4 years, BMI was 23.7 ± 2.6 kg/m2 and all women had uncomplicated pregnancies with normal perinatal outcome. The median gestational age at examination was 21 weeks in GA I, 29 weeks in GA II and 38 weeks in GA III. The total number of analyzed traces including all walls and ROI sizes were 45, 72 and 144 respectively. The axial resolution of images estimated by the median number of points/mm was 1.46 (range, 1.31–1.49), the median frame rate (temporal resolution) was 190 (range, 179–219) per second, and the line density (spatial resolution) was 20 (range, 20–28). The median height of the color box during the examination was 10.8 cm (7.2–12.7 cm).
The different ROI sizes used in each gestational age group, the total number of traces with an acceleration score of 3, mean ventricular length of the septum and percentage of the ventricular length occupied by each ROI size are presented in Table 1. The number of traces with an acceleration score of 3 increased with ROI length in GA II and GA III but not in GA I. All velocity traces were possible to analyze with the manual method to identify and measure the cardiac cycle time intervals. Out of the total 261 traces, it was possible to analyze 203 (78 %) of traces with the automated algorithm. It was possible to analyze 93 % (81/87) of traces recorded from the right ventricular wall, 82 % (71/87) from the left ventricular wall and 59 % (51/87) from the septum. The average acceleration score was 2.80 for the left ventricular wall, 2.67 for the right ventricular wall and 2.51 for the septum. The automated analysis with three exported velocity traces required <1 s for analysis compared to the manual method that required approximately 2–3 min.
The percent differences in velocities measured using different ROI lengths compared to the reference ROI of 2×2 are shown in Table 2 and Fig. 4. There was a clear trend towards decreasing myocardial velocities with increasing ROI length. The interquartile range also increased substantially with increasing ROI length. However, the cardiac cycle time intervals showed minimal variation irrespective of which ROI size was used (Table 3).
Functional fetal echocardiography using TDI is a promising tool in experienced hands for a selected group of patients. However, its introduction to more general clinical practice is hampered partly because it is cumbersome and time consuming. Our study indicates that automated analysis of fetal cardiac function assessed by color TDI is feasible using a newly developed algorithm. If the automated method could be used for instantaneous on-line display of results it could prove to be clinically useful. The automated technique requires substantially less time to analyze the TDI velocity traces compared to the manual method. The method is not dependent on an ECG in order to define time intervals and therefore suitable for antenatal assessment of human fetuses. As the automated method uses enhanced acceleration shifts rather than crossing points of velocity traces with the baseline for defining different phases of the cardiac cycle, it can be expected to reduce the errors related to fetal breathing and movements. Furthermore, multiple cardiac cycles can be evaluated quickly and averaged, which could result in a potentially higher accuracy of measurements compared to a manual analysis.
The automated method appears to be dependent on the quality of velocity traces and its derivatives, i.e. acceleration traces, and these seem to vary with the size of the ROI. The fetal heart grows considerably throughout gestation. Tan et al. have measured the thickness of the septum in a fetal four chamber view at end-diastole giving wall dimensions of 1.8 mm, 2.9 mm and 3.6 mm at a gestational age of 20, 30 and 40 weeks respectively. Studies of the right ventricular cavity at end-diastole demonstrate the length to be 12 mm, 20 mm and 26 mm at 20, 30 and 40 weeks respectively [24, 25]. As the fetal heart grows with advancing gestation we would suggest increasing ROI sizes with increasing gestational age. The width of the ROI should cover the width of the wall measured and, therefore, it seems adequate to choose 2 mm in GA I, 3 mm in GA II and 4 mm in GA III. While choosing ROI length the one producing distinct acceleration traces should be selected in order to optimize the automated method. However, an excessive loss of velocity information should be avoided. Therefore we suggest the use of a 2×2 mm ROI in GA I (18–24 weeks), a 4×3 mm ROI in GA II (25–32 weeks) and a 6×4 mm ROI in GA III (33–41 weeks).
TDI might be a useful method in assessing fetal cardiac function, but there is a lack of standardization concerning image acquisition, data analysis and post-processing. As we use a fixed (stationary) ROI placed at the level of the AV-plane at end systole, the myocardium apical to the original position will be interrogated during the rest of the cardiac cycle. Therefore, it might be important to choose a reasonably large ROI to reduce the variability associated with operator placement of the ROI . Substantial loss of velocity information and increasing interquartile ranges with increasing ROI length are limitations that should be considered while assessing myocardial velocities. The main focus of this automated method was, however, the assessment of cardiac cycle time intervals, and a larger ROI size seems to optimize traces for this purpose and consequently could improve automation.
Although only a small number of women with normal pregnancies were examined, for a feasibility study we had a reasonable number of traces (n = 261) to evaluate. However, all color TDI recordings are unlikely to be adequate for evaluation even by manual method in a larger unselected population. The accuracy of the automated algorithm should be tested in a larger population including pathological pregnancies.
Lotta Herling and Jonas Johnson contributed equally to this work.
We thank Dr Bodil Hvingel for recruiting participants to this study and performing ultrasound examinations. This study was funded by grants from the Regional Health Authority of North Norway (Grant No. SFP 873-09) and the Swedish Heart-Lung Foundation (Grant No. 20130672).
JJ is a member of the Board in Gripping Heart AB.
GA, MW had the original idea, GA, MW, LH, JJ, PL designed the study, GA, LH, JJ collected and analyzed data, GA, LH, JJ, KFW, MW interpreted the results, LH, JJ, GA and MW were involved in drafting the manuscript. All authors critically revised the manuscript and authors approved the final version.
Støylen A. Basic ultrasound, echocardiography and Doppler for clinicians. 2015:http://folk.ntnu.no/stoylen/strainrate/Ultrasound/index.html#Doppler.


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Memory - well that sounds so familiar! Every child must be given enough advice on ways to improve memory. Why don't you improve your memory? What makes you think that you have a bad memory? What are you doing to improve your memory to help you study better? Are you changing your learning skills and study skills and adopting new learning styles to improve your studying? Well these are some of the common questions that students across the globe have to answer in their constant efforts and trials with various modes of studying.
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You see when people are getting out of extreme tensions like in Rwanda, one cannot simply assume that overnight people will begin to see themselves as being colleagues and members of the same community, of the same country. So putting the tribunal in Rwanda at that time would have I think exacerbated the tensions.
That's a real possibility because when you get to know Rwanda very well you find that there are individuals who did not only lose the entire members of their family but a whole community, a whole village is destroyed and you cannot imagine the anger of these individuals, how they would react. I think they needed a cooling down period. 'Kay?
Now after 14 years I believe trial can now be held in Rwanda now; pe-, they are fairly calm, they have, they have been able to address this, to reflect on this and also they have read what outsiders say about the conflict in Rwanda. There is now a basis upon which they can objectively try and look at those issues but to have put the tribunal there in 1994, my personal view is that would have been a great mistake.


Desdemona loses the handkerchief by accident, it is found by Emilia and she gives it to Iago.
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Emilia finds out by walking in on the incident. But she tells Othello that it was all a lie and basically snitches on Iago. Iago walks in then stabs her for snitching on him.


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Q: Xamarin.Forms: issues positioning labels and setting row height? My xaml has 6 labels that display data. I'm trying to set them, but I'm having trouble doing so. This is how the form should be rendered:

Here's what I've tried so far. Here's the xaml:
<?xml version="1.0" encoding="utf-8" ?>
<ContentPage xmlns="http://xamarin.com/schemas/2014/forms"
             xmlns:x="http://schemas.microsoft.com/winfx/2009/xaml"
             xmlns:maps="clr-namespace:Xamarin.Forms.Maps;assembly=Xamarin.Forms.Maps"
             xmlns:local="clr-namespace:GasStations"
             x:Class="GasStations.MainPage">

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</ContentPage>

This is the result. It clearly doesn't look anything like the image above:

Besides all the issues with the labels, what doesn't seem to change is the row height: <RowDefinition Height="300"> doesn't change anything, and neither does HeightRequest="200".
Any help is appreciated.

A: The ViewCell definition you have defines a Grid with a single cell inside it (one row and one column.  From the UI example you have, it looks more like what you want is 2 columns and 3 rows, something like this:
<ViewCell>
    <Grid Padding="10,10,10,10">
        <Grid.RowDefinitions>
            <RowDefinition Height="Auto"></RowDefinition>
            <RowDefinition Height="Auto"></RowDefinition>
            <RowDefinition Height="Auto"></RowDefinition>
        </Grid.RowDefinitions>
        <Grid.ColumnDefinitions>
            <ColumnDefinition Width="*"></ColumnDefinition>
            <ColumnDefinition Width="*"></ColumnDefinition>
        </Grid.ColumnDefinitions>
        <Label Text="{Binding Name}" FontSize="15" TextColor="Black" Grid.Row="0" Grid.Column="0"/>
        <Label Text="{Binding Description}" FontSize="15" TextColor="Black" Grid.Row="1" Grid.Column="0"/>
        <Label Text="{Binding Lon}" FontSize="15" TextColor="White" BackgroundColor="#2FA4D9" Grid.Row="0" Grid.Column="1"/>
        <Label Text="{Binding Lat}" FontSize="16" TextColor="White" BackgroundColor="#2FA4D9" Grid.Row="1" Grid.Column="1"/>
    </Grid>
</ViewCell>

This is based on the code sample you have, so won't completely implement the UI design, but should get closer.  The key is to have the Labels in their own cell in the Grid rather than having them all in a single StackLayout.
You will also likely need to set the RowHeight (as Jason noted) or set HasUnevenRows="true" on the ListView.

redpajama_set_name: RedPajamaStackExchange


With quick access to highways, shopping & dining, this beautiful home has been updated & upgraded! Freshly painted throughout, hardwoods greet in the fireside family room with soaring ceilings & skylights. Back of home holds an updated kitchen with granite, tile back splash, stainless appliances, & bar area, with an island overlooking a sunny breakfast room. Screened in porch holds spa area with hot tub, & back patio has pergola area for relaxing. 2 bedrooms on main share a full bath & upstairs, master retreat has full ensuite bath with jetted soaking tub!
Hello, I'd like more information about the listing I found on Homes.com at 193 Clydesdale Lane Se.
This home is located at 193 Clydesdale Lane Se Mableton, GA 30126 US and has been listed on Homes.com since 25 March 2019 and is currently priced at $190,000, approximately $72 per square foot. This property was built in 1989. 193 Clydesdale Lane Se is within the school district(s) Cobb County School District with nearby schools including Harmony-leland Elementary School, Lindley Middle School, and Pebblebrook High School. Similar properties nearby are 193 Clydesdale Ln Se, 833 Harwell Rd Nw, 5932 Gresham Pl Sw, 1171 Dillon Rd, 6111 Thunderwood Rd Sw, and 271 Deidra Dr Se.


Abstract Template matching is an effective approach for pedestrian detection. In order to achieve real-time and accurate detection, how to obtain a suitable representative template set is still an open problem due to the large variety of pedestrian shape. This paper introduced a representative template generation method for a template matching based pedestrian detection system (PDS). Based on nonlinear manifold learning and clustering, the new approach can generate a suitable representative template subset from a large amount of original templates. First, an improved nonlinear dimensionality reduction method was proposed to map original templates to feature vectors (points) in the low-dimensional embedding space; Second, representative points were generated in the embedding space by clustering; At the end, corresponding representative template set were synthesized by mapping inversely the newly generated points from the embedding space to the visual input space. The experimental results showed that the template generation method speeds up detection procedure without considerable loss of performance.
GB/T 7714 Wu, Pei,Cao, Xian-Bin,Xu, Yan-Wu,et al. Representative Template Set Generation Method for Pedestrian Detection[C],2008.


text:
News Release 24-Apr-2019
Nanosized container with photoswitches: release of cargo upon irradiation in water
A versatile system with potential application for non-invasive drug delivery
IMAGE: Chemical structures of the previous (left) and new amphiphile (right). Light irradiation induces a structural change from the open to the closed form of the amphiphile. view more
Credit: ©Tokyo Tech
Researchers at Tokyo Tech's Laboratory for Chemistry and Life Science have developed a micelle-type nano-container that can be switched between its assembled and disassembled state via simple light irradiation. The light stimulus induces a structural change in the amphiphilic subunits, which closes their integrated binding pocket and simultaneously results in disassembly (see Figure 2).
In a recent publication in Nature Communications, Lorenzo Catti (JSPS/Humboldt postdoctoral fellow), Natsuki Kishida, Michito Yoshizawa and co-workers successfully demonstrates how to combine the use of water and light, both essential ingredients for life, in an environmentally benign delivery system. "Water and light are abundant and clean resources on earth," Dr. Yoshizawa says. "Active use of both of them in synthetic and materials chemistry has seldom been accomplished so far but is and urgent necessity for the development of sustainable modern technologies".
The achievement is grounded on a small design change in the subunit of the nanosized container. By moving the two polyaromatic[1] panels on a previous amphiphilic compound (Figure 2, left) one carbon atom closer together, the authors enabled a photochemical reaction between the panels that results in quantitative closing of the binding pocket (Figure 2, right). In addition, the group could show that this reaction is partially and fully reversible by light irradiation and heating, respectively.
The study is part of the groups ongoing effort towards environmentally benign nanoflask systems with controllable functionality. The new system can be considered an "aromatic micelle", a concept that was introduced by the group in 2013.
Uptake of water-insoluble guest molecules into the container was shown to be easily achievable via a simple grinding protocol. Addition of water to the resulting solids gave characteristically colored solutions, which displayed UV-visible absorption bands assignable to the bound guest molecules. The flexible character of the nano-container allowed the uptake of a wide variety of compounds, such as rod-shaped and planar dyes and spherical fullerenes, in water. Quantitative release of the guest compounds could be achieved via irradiation of the aqueous solution for 10 min at room temperature. The released, water-insoluble guests could furthermore be successfully recovered via simple filtration, giving rise to a clear colorless solution containing only the closed amphiphiles.
"In a biomedical context, the developed system holds great promise for future progress in non-invasive delivery of biomolecules and synthetic drugs," Dr. Yoshizawa concluded. Future improvements of the system are aimed at allowing a weaker light source for irradiation, which will bring the system one step closer to the envisioned in-vivo delivery application.
[1] Polyaromatic: Planar molecular structure composed of several bezene rings fused together
Kazuhide Hasegawa
media@jim.titech.ac.jp
http://www.titech.ac.jp/english/index.html
Japan Society for the Promotion of Science, Tokyo Institute of Technology
Figure 1: The Nanosized Container Quantitatively Releases the Cargo upon Light-Stimulus (IMAGE)
Figure 2: Design of the New Amphiphilc Compound Bearing a Photoswitch (IMAGE)
http://dx.doi.org/10.1038/s41467-019-09928-x

redpajama_set_name: RedPajamaCommonCrawl


Now that I have finished Wonder Woman, well Brian Azzarello and Cliff Chiang's story, I can devote my interest to another series, Saga. This series is one that I often stopped upon as I browsed through the shelves in Barnes and Noble tempting myself and taking notes of my "To-Reads." I was with my boyfriend and we were going through our typical routine, heading straight upstairs to the comics and graphic novel section, and I began telling him how much I have heard about this series, but I was torn because I did not want to start a new series before finishing all of my other ones. Now this is not because I cannot invest my time into different books at once, I have been trained to do this and I am convinced that I am genetically programmed to do this as well. Instead, I need to have and usually own the physical copy. I don't like to begin a new series because it adds onto the volumes that I have to collect which lessens the amount in my bank account as well as my already incredibly limited shelf space. As my birthday was approaching, my boyfriend gifted me these 5 volumes. I read the first two immediately and became hooked, but all the craziness due to mid-semester as well as preparing for my sister's bridal shower caused me to place Saga on the back burner. Seeing that I am done with the spring semester and have a minor break until the summer semester starts, I am going to re-read the first two volumes as well as the rest that I own. I am fully aware that I do not own the entire series and that it is still being produced, but remaining on a cliffhanger is a consequence that I am willing to take because I am dying to find out what happens after Volume 2.
exposed to "the classics," as I found myself primarily taking elective courses that focused on contemporary novels aside from my mandatory survey courses. In the survey classes, we learned from anthologies, so I read bits and pieces of different classics but rarely a classic in its entirety. I seem to have more knowledge in contemporary texts, which is why I enrolled in summer courses that focus on readings I am "expected" to know. I constantly have people asking me if I read certain works and once they hear: No, I have never read Jane Eyre. To Kill a Mockingbird? Yeah I heard of it, I did not read it though, I find that their eyes widen as they say, "Well aren't you an English major?" Yes, I am an English major, NO that does not mean that I have read every popular American literature that exists. I am aware that these books appear on lists such as "Books that Everyone Should Read" or "The Greatest Novels of All Time," but my major in English stems from my love of reading literature – any kind. This is why I used my electives in college to expose me to texts that are not as accessible, to broaden my horizons, but now that my college experience is coming to an end, I decided that I should turn to authors, or to be politically correct, playwrights, like Shakespeare because I will probably be more inclined to pick up Jane Eyre over the summer to read (which I will do since it is one of my unread and owned books) than I will be inclined to pick up A Midsummer Night's Dream. I believe that a course on Shakespeare is necessary because his writing is so important but it often needs a certain amount of guidance to fully be appreciated.
The first time I read Romeo and Juliet was last year while I was student teaching, I read Macbeth in 9th grade, I read excerpts from The Tempest during a Comparative Literature course, and in middle school a theater company came to our school and performed Othello. That is the extent of my familiarity of Shakespeare and I feel like it is such a shame considering that he is highly influential in literature and I will most likely be expected to teach one of his plays at one point in my life. Part of me is happy that most of the works that I am required to read are not the plays that you typically think of when you hear Shakespeare, yet another part of me is a little upset that I will not be reading his more well-known works because I feel like those are the plays that I will most likely find on a future curriculum. Yet seeing that I already have a basic knowledge on Macbeth, Othello, and having read and taught Romeo and Juliet, it will be interesting to discover works by Shakespeare that I would not have selected myself.
That moment that it hit me that I had a problem.
Today I went to Strand, and as this picture that captures me in my natural habitat shows, I got quite a few books.
I then went to a comic store and got quite a few comics.
I then vowed to myself that I would not buy a new book until I have read all the books that I own (I have a bad habit of buying new books before reading my other books and they then become forgotten place-holders on my shelf).
Unfortunately this means that even though some of my books are part of a series, I will not be able to continue it before everything else is done.
This post is meant to keep this vow in writing so that I am physically bound to it, of course if I do become weak I can always delete this post and claim it never happened but I like to think that I will be stronger than that.
Excited to soon be able to say that I have read every book that I own!


text:
Fleyout is a easy, declarative, compatible CSS flexbox layout.

## Benefits
- **Easy** — Only using two attributes(`layout` and `flex`) in html
- **Declaravtive** - Semantic syntax makes you understand what happened
- **Compatible** - Supported old version flexbox, it is compatible with many old browser include `<Android 4.4`

## Install

```
npm install fleyout
```

## Basic example

```
<div layout="row center-center">
    <div flex="1">flex-grow is 1</div>
    <div flex="2">flex-grow is 2</div>
</div>
```

## Two attributes
Use `layout` and `flex` attribute in HTML control layout.
using `layout` in parent container, using `flex` in child.

### layout
`layout` can contain multiple values.

value | meaning
----- |  ------
`row` | `flex-direction: row`
`col` | `flex-direction: column`
`rows`| `flex-direction: row` and `flex-wrap: wrap`
`cols`| `flex-direction: col` and `flex-wrap: wrap`
`inline` | `display: inline-flex`
`start-end` and so on. Format is `mainAxis-crossAxis`  | Main axis(justify-content) is flex-start , cross axis(align-items) is end. Main axis placeholder can be `start`, `end`, `center`, `around`, `between`, cross axis placeholder can be `start`, `end`, `center`, `baseline`, `stretch`.

Example:

```
<div layout="rows inline center-stretch">
    ...
</div>

<div layout="col end-start">
    ...
</div>
```

### flex
`flex` can be value from 1 to 12.
`flex="1"` means `flex-grow: 1`

Example:

```
<div layout="row  center-stretch">
    <div flex="1"> flex-grow is 1 </div>
    <div flex="2"> flex-grow is 2 </div>
</div>
```

redpajama_set_name: RedPajamaGithub


text:
BREAKING: FG Drags ASUU To Court Over University Strike, Says Negotiations Have Failed
The raging dispute between the federal government and the Academic Staff Union of Universities (ASUU) that has kept many universities shut for more than seven months will shift to the Industrial court next Monday.
ASUU had embarked on strike since February 15 to protest alleged decay of infrastructure at the various institutions, as well as neglect of the welfare of its members.
A reliable source at the Federal Ministry of Labour said that the ministry's Trade Dispute Department had filed a case before the Industrial Arbitration Court in Abuja and that the hearing would commence next Monday.
According to the source, "The federal government has filed a case at the Industrial Court challenging the continued strike by the university teachers. This is in conformity with Section 17 of the Trade Dispute Act."
There have been series of negotiations between the federal government and the ASUU leadership but all ended in stalemate without a tangible outcome.
However, talks between the federal government and ASUU finally hit the rocks last Tuesday after both sides met at the National University Commission's office in Abuja.
The federal government had said that it would not sign any other agreement it cannot implement.
Minister of Education, Malam Adamu Adamu, disclosed this during a meeting of Pro-Chancellors and Vice Chancellors of Federal Universities, held at the NUC's office.
Adamu said President Muhammadu Buhari had warned the government's team involved in the negotiation with ASUU against signing an agreement that the government would not be able to fulfil.
The minister said the government had offered the union a 23.5 per cent salary increase "for all categories of the workforce in federal universities, except for the professorial cadre which will enjoy a 35 per cent upward review. He said the government had also promised that N150 billion "shall be provided for in the 2023 Budget as funds for the revitalisation of federal universities, to be disbursed to the Institutions in the First Quarter of the year."
Also, the government said N50 billion would be provided "for in the 2023 Budget for the payment of outstanding arrears of earned academic allowances, to be paid in the first quarter of the year."
However, ASUU and three other university unions have rejected the offer, describing it as "inadequate to meet their respective demands needed to tackle the challenges confronting the university system."
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text:
Denmark Hill ist der Name einer Straße und eines Gebiets im Londoner Stadtteil Camberwell des Bezirks Southwark östlich von Brixton und nördlich von Herne Hill.

Geschichte

Namenspate für Denmark Hill war wohl Prinz Georg von Dänemark (1653–1708), der Ehemann der Königin Anne von Großbritannien (1665–1714), der auf dem damals noch kaum bebauten Gebiet gerne zur Jagd ging. Ein Großteil der Ländereien von Denmark Hill und Herne Hill wurde 1783 vom wohlhabenden Holzhändler Samuel Sanders käuflich erworben. Kurz darauf ließ er dort ein Herrenhaus für sich errichten. Bis zur Mitte des 19. Jahrhunderts kamen weitere Häuser hinzu, die mit Ausnahme von drei Gebäuden wieder verschwunden sind. Diese stehen auf dem Gelände des heutigen King's College Hospital.

Während des Zweiten Weltkriegs befand sich in der Straße Grove Park Nr. 113 eine wichtige Funkabhörstelle des britischen Geheimdienstes, genannt Denmark Hill Y Station. Sie lag innerhalb der damaligen Polizeidienststelle der Metropolitan Police von Denmark Hill.

Infrastruktur
Heute liegen auf dem Gebiet von Denmark Hill außer dem King's College Hospital das King's College London mit dem Cicely Saunders Institute, das William Booth College, das Maudsley Hospital, der Bahnhof Denmark Hill sowie der
Ruskin Park.

Persönlichkeiten
 Samuel Prout (1783–1852), Maler
 Sir Henry Bessemer (1813–1898), Ingenieur und Erfinder
 Stan Tracey (1956–2013), Musiker
 Danny Kirwan (1950–2018), Musiker
 Jenny Agutter (* 1952), Schauspielerin
 Rio Ferdinand (* 1978), Fußballspieler

Weblinks

Einzelnachweise

Stadtteil von London
Geographie (London Borough of Lambeth)
Geographie (London Borough of Southwark)

redpajama_set_name: RedPajamaWikipedia


text:
US Alessandria Calcio 1912 is een Italiaanse voetbalclub uit de stad Alessandria.

Geschiedenis
De club werd gesticht als FBC Alessandria in 1912 en speelde in 1913 voor het eerst in de hoogste klasse, die nog regionaal gespeeld werd in die tijd. In 1920 fusioneerde de club met US Alessandrina (opgericht in 1915) en nam nu de naam US Alessandria aan. In 1929 was de club medeoprichter van de Serie A en bleef daar spelen tot 1937 met een 6de plaats als hoogste positie. In 1946 keerde de club terug voor 2 seizoenen en later nog eens van 1957 tot 1960, daarna speelde de club nooit meer in de Serie A. In 1967 degradeerde de club naar de Serie C en kon enkel nog in 1974/75 even terugkeren naar de Serie B.

In 2003 degradeerde de club voor het eerst in zijn bestaan naar de Serie D en ging failliet. De club werd heropgericht onder de huidige naam en begon in de Eccellenza, een amateurliga en werd daarin kampioen. De club promoveerde in 2009 naar de Lega Pro Prima Divisione.

Na de overwinning tegen Genoa in de Coppa Italia 2015/16 werd Alessandria de eerste ploeg uit de Serie C die de kwartfinale haalde in de Italiaanse beker sinds Bari in het seizoen 1983/84. In de kwartfinale werd een 2–1 overwinning behaald tegen Spezia. In de halve finale was AC Milan een maatje te groot. Thuis werd er 0–1 verloren en in San Siro werd het 5–0.

Eindklasseringen

Alessandria in Europa
 Groep = groepsfase, T/U = Thuis/Uit, W = Wedstrijd .

Uitslagen vanuit gezichtspunt US Alessandria

Bekende (oud-)spelers
  Gino Armano
  Adolfo Baloncieri
  Luigi Bertolini
  Valerio Bertotto
  Felice Borel
  Giancarlo Camolese
  Renzo Cappellaro
  Renato Cattaneo
  Gianni Fanello
  Enrico Fantini
  Giovanni Ferrari
  Dino Galparoli
  Francisco Ramón Lojacono
  Edoardo Reja
  Gianni Rivera
  Roger Vonlanthen
  Árpád Weisz

Externe links
 Officiële website
 Unione Sportiva Alessandria 1912 - Short Historical Overview 1896-1961  prepared by Enrico Acerbi for RSSSF
 Associazione Orgoglio Grigio  'Grey Pride Association': a supporters site

Alessandria
Sport in Piëmont
Alessandria


Big things from this game!
I seriously don't think I ever believed he'd be on the pitch again until I saw it today–not even on the weekend when he was on the bench. What a story, and what a comeback. He looked very good on the field as well–no rust at all after a whole year off.
More than one report I've read called this a "revolution", and I guess it's sort of hard to understate the significance not only of playing 5 across the back (which seems like a fairly logical reaction to the fact that our defense has been terrible all year), but also choosing to sit three players (Navas, Perroti, Capel) who play the position that is our most consistent source of danger and has been really the foundation of our team's greatest successes in the past decade. It would've been interesting (and will be interesting, if we see this formation again) to see what Manzano would've done if we found ourselves needing a goal–he certainly had a lot of firepower to choose from. Even with this defensive lineup, Kanoute often drifted deep to receive and help with possession in the midfield. That guy is a beast and surely instrumental to our success this year. Also fantastic today: Negredo, who didn't score but kept their defense occupied all night (and didn't make me hope for LuFa at any moment); Varas, who made several key saves when the game was at 1-0 and very much still in doubt; and Romaric, who assisted on 5 of the 6 goals of this tie and played the pass that led to the ball for the other (the first goal tonight). Fantastic stretch for him.
That doesn't really need any further elaboration, does it? Unless you want to also add "6-3 aggregate", which doesn't look too bad either. On to a Madrid team next, then. Personally, I'd love to see RM–how amazing would it be to face 3rd in Liga, then 2nd, then 1st on the way to the Copa? Not that we'd be guaranteed victory by any means, but it would feel very good indeed to pull it off.


@basard Where did you find this!? if the 3700X is really this @ that price it will blow the 9900K out of the water... so long as you can effecftively OC at 5.0 Ghz. This could be the shift that AMD has been pushing for a few years now.
I really hope we get some more concepts coming soon, buccaneer was great, but really interested what they are going to have offer for ground combat. With the death mechanics of the game, I wonder what would entice someone to focus on ground based combat, without seeing any ground concept concepts other than the rover and dragonfly, and if they are it I would stay off the ground, especially if orbital strikes are potentially coming into the game... I know its still a rumor, but itd be awesome..


text:
How to Draw a Hamburger
How to Draw A Cartoon Hamburger that looks original
Drawing a cartoon hamburger: some fun facts before starting sketching!
The word hamburger probably appeared in the end of the Middle Ages.
The cheeseburger was invented in 1924 by Lionel Sternberger.
Billions of hamburgers are sold in the US each years...
In this "how to draw food" example, you will learn how to draw a hamburger. A good hamburger is made of a bun (1), beef (3), some lettuce (5) and tomatoes (2). You can also add ketchup, onions and mustard. And last but not least, you can add a slice of real cheese, some pickles and mayonnaise. But try to not add all of these in the same hamburger!
If you take a look at the shapes of this gigantic and delicious hamburger, you should notice that it is mainly made of circles. Lucky enough, I did use some colors to make sure the whole thing could be readable. Now let's see how we could draw a simple, funny cartoon character in the shape of a hamburger!
First, draw two rectangles to represent the buns. Then, add four small rectangles to make the arms and the legs of our character. Next, work on the outline of the buns.
When you are finished, make sure the arms and the legs are also well drawn. Then, add details like the eyes and the beef. Adding some color will make the final image really more alive!
Drawing a nice hamburger is really simple if you can easily draw a circle. You can make it funny (3), realistic (1) or a little more simpler (2). Don't hesitate to play with your hamburger and add the ingredients of your choice. Great! More delicious food from this site can be drawn below. Enjoy! :)
How to draw bacon
How to draw eggs
How to draw ham
How to draw a sandwich
How to draw a sushi
Go back to How to draw cartoon food
Go back from How to draw a cartoon hamburger to home page


Remarkable, and surprising European Cabinet Card image of famed and lovely Bearded Woman, Annie Jones. Dressed here in tux and tails, she holds a top hat. Never before-- or since-- have we seen Annie, the scion of womanhood, dressed the least little bit masculine. Here, in this image she could pass for a very handsome man! Photo by W. NESTLER, Bruxelles [Belgium].


text:
Q: Counting number of documents in an index in elasticsearch I'm doing a bulk operation to index 100 documents at once using the python ElasticSearch Client. I want to count the total number of documents in an index. So I do the bulk op and then count the number of documents in an index as below:
helpers.bulk(es_client, actions);
es_client.count('index').get('count')

However the second line still returns the old count, and I tried to run the second line from a different file, which returns the correct result. I suspect that bulk op is not yet completed. Please correct me if I'm wrong, and what would be the workaround to do what I want?

A: I found this in the examples that I attach below
es=Elasticsearch([{'host':'url','port':'9200','timeout':60}])
res = es.count(index='your index', doc_type='your doc_type', body={'query': your query })["count"]

If it helps you, here are good examples of count with Python:
https://python.hotexamples.com/examples/elasticsearch/Elasticsearch/count/python-elasticsearch-count-method-examples.html

A: You have to use refresh API:

POST /index/_refresh

The refresh API allows to explicitly refresh one or more index, making all operations performed since the last refresh available for search. The (near) real-time capabilities depend on the index engine used. For example, the internal one requires refresh to be called, but by default a refresh is scheduled periodically.

For more info look at https://www.elastic.co/guide/en/elasticsearch/reference/current/indices-refresh.html

A: get the index document count in python
es.indices.refresh(index_name)
es.cat.count(index_name, params={"format": "json"})


text:
Week of Oct. 31, 2011: Pfizer Completes Acquisition of Icagen; 3M Drug Delivery Systems Names James Ingebrand Vice-President and General Manager; and More
Pharmaceutical Technology Editors
Pfizer Completes Acquisition of Icagen; 3M Drug Delivery Systems Names James Ingebrand Vice-President and General Manager; and More.
Company Notes
AgonOx has entered into an exclusive global partnership with MedImmune, the global biologics arm of AstraZeneca, to develop agonists using its OX40 platform. MedImmune will lead further preclinical and clinical studies of its tumor-specific T-cell immunity stimulator for the potential treatment of cancer. MedImmune will also support further OX40 research at Providence Cancer Center, where the foundational preclinical and clinical development of OX40 has been conducted.
Bristol-Myers Squibb (BMS) and Gilead Sciences have announced a licensing agreement for BMS to develop and commercialize a fixed-dose combination containing BMS's protease inhibitor Reyataz (atazanavir sulfate) and Gilead's cobicistat, a pharmacoenhancing agent that increases blood levels of certain HIV medicines to potentially allow for once-a-day dosing. Gilead conducting a study of atazanavir and cobicistat in Phase II and III studies for HIV-1 treatment-naïve patients.
Cobra Biologics, the biopharmaceutical manufacturing company has acquired the CMO Unitech Pharma Group and its bioproduction facility in Matfors, Sweden. Under the terms of the agreement, Cobra Biologics will acquire 100% of the shareholding in Unitech Pharma Group, which has a 600 L of clinical and commercial microbial GMP production capacity, and commercial aseptic fill–finish and lyophilization capability.
Lonza has announced a new development and manufacturing agreement with the biotechnology company Genmab. The agreement secures a development and cGMP manufacturing plan for Genmab to produce an antibody–drug conjugate (ADC) product targeting tissue factor (TF), a protein involved in tumor signaling and angiogenesis that is highly expressed on solid tumors. The project utilizes Lonza's experts in both antibody production and drug conjugation, providing a harmonized solution for Genmab's technology. Lonza will initiate process development and cGMP manufacturing for Genmab's monoclonal antibody HuMax-TF in its Slough, United Kingdom, facility. The antibody has been expressed by Genmab in Lonza's glutamine synthetase gene-expression system. The naked antibody will be conjugated by Lonza at its ADC plant in Visp, Switzerland, to a cytotoxic drug to form the antibody drug conjugate HuMax-TF.
Pfizer has completed its $56-million acquisition of the biopharmaceutical company Icagen by merging its wholly owned subsidiary, Eclipse Acquisition Corp., with and into Icagen. Under the transaction, Icagen has become a wholly owned subsidiary of Pfizer, and each issued and outstanding share of Icagen common stock has been converted into the right to receive $6.00 in cash.
ShangPharma, a CRO, has acquired the assets in the drug-development company Charles River Laboratories's Shanghai, China, research facility, through its subsidiary Shanghai ChemPartner. Under the transaction, ShangPharma will take over Charles River's lease for the facility, which will provide the company with an additional 2972 m2 (31,990 ft2) of in vivo research facilities originally designed for GLP toxicology studies, and 1290 m2 (13,885 ft2) of lab and office space.
People Notes
3M Drug Delivery Systems has appointed James Ingebrand as vice-president and general manager, following the retirement of his predecessor James Vaughn.
The CRO ICON has appointed Steve Cutler as group president of clinical research services. Cutler previously served as CEO of the CRO Kendle.
Industry News | PharmTech News


text:
Alloasteropetes olivacea är en fjärilsart som beskrevs av Kishida och Yoshiyuki Machijima 1994. Alloasteropetes olivacea ingår i släktet Alloasteropetes och familjen nattflyn. Inga underarter finns listade i Catalogue of Life.

Källor

Externa länkar

Nattflyn
olivacea


text:
California EDM Events
Las Vegas EDM Events
The FBI is Asking Attendees to Submit Videos From Astroworld Festival in New Investigation
Above & Beyond Announce Lineup For Group Therapy Weekender 2022 At The Gorge
Insomniac Is Set To Take Over Omnia San Diego Nightclub
Basscon Reveals A HUGE Lineup For WASTELAND 2022
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text:
Gran Torino je drama Clinta Eastwooda iz 2008. Osim Eastwooda, u filmu nastupa uglavnom glumačka postava koju čine Hmongi, kao i Eastwoodov mlađi sin, Scott Eastwood. Njegov stariji sin, Kyle Eastwood, skladao je glazbu za film koji se 12. prosinca 2008. počeo prikazivati u manjem broju kina u SAD-u, dok je 9. siječnja 2009. krenuo u široku distribuciju.

Radnja

Walt Kowalski, veteran Korejskog rata, živi u četvrti Detroita koja se sve više mijenja i u kojoj dominiraju imigranti. Film počinje sa sprovodom njegove žene i prizemnim govorom oca Janovicha. Čini se kako Kowalski ne može podnijeti svoja dva sina i njihove obitelji koji pokazuju malo poštovanja prema njemu i pokojnoj majci. Tijekom filma Walt ih opisuje kao razmaFkoju sižene i zaokupljene samima sobom te da ga izbjegavaju, osim onda kad je to u njihovu interesu.

Waltovi susjedi tinejdžeri, Thao i Sue Vang Lor, žive s majkom i ekscentričnom bakom. Nakon što Thaoa napadne rasistički nastrojena hispanska banda, banda Hmonga, predvođena Thaovim starijim rođakom Paukom, umiješa se kako bi spasila malog rođaka. Hmong banda na licu mjesta pokuša nagovoriti Thaoa da im se pridruži. Proces Thaove inicijacije sastoji se u tome da ukrade Waltov Ford Gran Torino iz 1972. Walt ga uhvati u pokušaju krađe, uperivši mu pušku u lice i prisilivši ga da pobjegne. Nakon nekoliko dana, Pauk i njegova banda se vraćaju. Uz pomoć svoje sestre, Thao se uspijeva verbalno suprotstaviti bandi. No, banda odvuče Thaoa s trijema u pokušaju da ga napadnu. Njegova obitelj u očaju se pokuša oduprijeti napadačima. Sukob završava nakon što Walt zaprijeti članovima bande svojom M-1 puškom, rekavši im da mu se maknu s travnjaka. Oni napuštaju četvrt, rekavši usput Waltu "da čuva leđa".

Vang Lorovi počnu zahvaljivati mrzovoljnom i nestrpljivom Waltu, koji inzistira da je samo želio da mu se "žuti" maknu s posjeda. Nakon što se susjedstvom pročulo za Waltov hrabri čin, nagrađuju ga ostavljajući mu na trijemu posuđe Hmonga i biljke. Walt nije zadovoljan, tražeći samo da ga puste na miru. Otac Janovich posjećuje Walta, podsjetivši ga na želju njegove žene da se ispovijedi. Walt odbije.

Nakon što je ugledao kako tri crnca uznemiruju Sue, Walt se usmiješa kako bi je spasio. Sue pomalo upoznaje Walta i dovodi ga svojoj obitelji. Sue, Thao i njihova majka sutradan počnu inzistirati da Thao počne raditi kao volonter za Wa lta kako bi mu otplatio dug te da bi ga starac očvrsnuo. On pronalazi Thaou građevinski posao i spaja ga s djevojkom Youaom, koju Walt naziva "Yum Yum".

U međuvremenu, banda Hmonga nastavlja vršiti pritisak na Thaoa da im se pridruži. Nakon što su ga uhvatili samog na ulici, opljačkaju ga i ugase mu cigaretu na licu. Walt se suprotstavi jednom od članova bande i prebije ga. Banda se vraća nekoliko dana kasnije i zapuca po kući Vang Lorovih, ranivši Thaoa u vrat. Sue, koja je napustila prijateljičinu kuću prije pucnjave, vraća se pretučena i silovana. Walt uleti natrag u kuću i u bijesu počne razbijati pokućstvo. Posjećuje ga otac Janovich. Dvojica popiju pivo i počnu razgovarati što će Walt napraviti. Nakon što je iskašljao krv, Walt posjeti liječnika i sazna da umire. Ode na ispovijed ocu Janovichu koji mu kaže da se moli.

Ljutiti Thao željan osvete planira se pridružiti Waltu u napadu na bandu. Walt ga odvede podrum, dadne mu svoju Srebrnu zvijezdu i zaključa ga unutra, rekavši mu kako ne želi da provede život s osjećajem krivnje jer je nekoga ubio. Kasnije nazove Sue i rekne joj da otključa podrum i pusti Thaoa. Walt dolazi pred kuću u kojoj obitava banda i počne ih proklinjati. Izvadi cigaretu iz jakne, stavi je u usta i upita ima li tko vatre. Zatim posegne po upaljač u jaknu, a banda u strahu otvori vatru. Nakon dolaska na mjesto zločina, Thaou i Sue policajac Hmong podrijetla kaže da je banda uhićena te da će dugo vremena provesti u zatvoru jer su ubili nenaoružana čovjeka. Hmong susjedi koji su svjedočili ubojstvu prekrše svoj zakon šutnje i odluče svjedočiti protiv članova bande.

Na misi zadušnici za Walta otac Janovich održi upečatljiv govor o pokojniku koji biva ukopan u odijelu po mjeri koje je sam kupio. Thao i njegova obitelj brojčano nadmašuju Waltovu, čiji se sin pita kako oni znaju Walta. U svojoj oporuci, Walt ostavlja svoju kuću Crkvi, a svoj Gran Torino Thaou, na veliko nezadovoljstvo svoje obitelji koja se nadala kako će naslijediti kuću te kako će Waltova nezahvalna unuka dobiti Gran Torino. U posljednjoj sceni, Thao vozi Gran Torino s Waltovim psom, Daisy.

Glumci

 Clint Eastwood kao Walt Kowalski, veteran Korejskog rata. Kowalskom su u životu bitne samo dvije stvari: Gran Torino iz 1972. i njegova M1 Garand iz rata. Eastwood je opisao odnos lika s tim objektima: "Radio je na tekućoj vrpci u pogonu Forda, umirovio se i taj automobil je jedina stvar koju je sam sebi priuštio. To je na neki način simbol njegovih dana u Fordu. M1 je simbol njegovih vojnih dana... On se oslanja na uspomene na rat. Otkrit ćete kad vidite, neke od uspomena nisu ugodne kao druge. To još više otežava njegov odnos s drugima." Dodao je: "On je jedan od onih tipova koji teško prihvaćaju promjenu... [a film] samo pokazuje kako teče njegov život i kako se on povezuje s Hmongima koji žive u susjednoj kući."
 Bee Vang kao Thao, Hmong tinejdžer uhvaćen u krađi Waltova Gran Torina. Bila je to prva Vangova glumačka uloga. Lik je opisan kao "slabić iz susjedstva", a velika razlika u visini između Thaoa i Kowalskog bila je namjerna kako bi odražavala mentorski odnos. Vang je rekao, "Thao se doslovno 'ugleda' na njega".
 Ahmey Her kao Sue, Thaova starija sestra. Sue služi kao Waltov vodič u njenu obitelj.
 Christopher Carley kao Otac Janovich, lokalni svećenik posvećen pomoći Waltu nakon smrti njegove žene.

U Gran Torinu se pojavljuju i Brooke Chia Thao kao Thaova majka i Chee Thao kao Thaova baka udovica. Peteročlanu bandu čine Sonny Vue kao vođa bande, "Smokie"; Doua Moua kao Fong (ili "Pauk"), Thaov i Suein stariji rođak; Jerry Lee, Elvis Thao i Lee Mong Vang. Glumačka postava većinom je sastavljena od Hmonga, što je vrlo neobično za američki mainstream film. Casting za Hmong glumce održan je u njihovim zajednicama u Saint Paulu, Fresnu i Detroitu. Svi osim jednog glavnih likova Hmonga su po prvi put glumili na filmu, kao što je to bio slučaj s većinom statista.

Produkcija

Gran Torino režirao je Clint Eastwood, dok scenarij potpisuje Nick Schenk. Producirale su ga kuće Village Roadshow Pictures, Media Magik Entertainment i Malpaso Productions za distributera Warner Bros. Eastwood je bio i jedan od producenata, uz Roberta Lorenza i Billa Gerbera. Originalni scenarij inspiriran je užim prstenom predgrađa Minneapolisa u Minnesoti, ali producenti su odlučili producirati film u državi Michigan jer je film postao jedan od prvih koji su iskoristili prednost novog državnog zakona koji omogućuje unosne poticajne pakete. Snimanje je započelo u srpnju 2008., a snimano je u Highland Parku, Center Lineu, Warrenu, Royal Oaku i Grosse Pointe Parku u Michiganu. Na produkciji su angažirani ekipa, produkcijski asistenti, konzultantni i statisti Hmong podrijetla.

Kritike

Nakon gledanja filma, The New York Times je naglasio posmrtni ton koji dominira filmom. Manohla Dargis iz Timesa usporedila je Eastwoodovu prisutnost u filmu s Prljavim Harryjem i Čovjekom bez imena, rekavši: "Prljavi Harry se na neki način vratio u Gran Torinu, ne kao lik nego duhom. On lebdi u filmu, u njegovim temama i slikama velikih kalibara, te naravno najočitije u licu g. Eastwooda. To je sada monumentalno lice, tako naborano i nabrano da više i ne izgleda isušeno, kao što je to bio slučaj proteklih desetljeća, ali čini se bližim okamenjenom drvetu." Na kraju ga je ocijenila s 4 od 5 zvjezdica. Los Angeles Times također je hvalio Eastwoodovu izvedbu i vjerodostojnost kao akcijskog junaka u dobi od 78 godina. Kenneth Turan komentirao je Eastwoodovu izvedbu: "To je film koji se ne može zamisliti bez glumca u glavnoj ulozi. Ideja o 78-godišnjem akcijskom junaku može zvučati kontradiktorno, ali Eastwood uspijeva, iako je njegova opasnost više verbalna nego fizička. Čak i sa 78, Eastwood može rečenicu 'Maknite se mog travnjaka' učiniti jednako prijetećom kao 'Uljepšaj mi dan', a kad kaže 'Probušit ću ti rupu u licu i zaspati kao beba', zvuči kao dao to zaista i misli." Prema podacima od 16. siječnja 2009., film na Rotten Tomatoesu ima 76 posto pozitivnih recenzija od ukupno njih 144. Na Metacriticu je rezultat 73/100 na temelju 23 recenzije.

Nagrade i nominacije

Gran Torino se našao na popisu deset najboljih filmova 2008. Američkog filmskog instituta. Izvedba Clinta Eastwooda također je pobrala mnoga priznanja. Osvojio je nagradu Nacionalnog ureda za kritiku za najboljeg glumca, a trenutno je nominiran za nagrade za najboljeg glumca Udruženja televizijskih, radijskih i internetskih filmskih kritičara i Udruženja filmskih kritičara Washingtona. Originalna pjesma iz filma, "Gran Torino", nominirana je za Zlatni globus za najbolju originalnu pjesmu. Glazbu potpisuju, Clint Eastwood, Jamie Cullum, Kyle Eastwood i Michael Stevens, a stihove Cullum. Ceh američkih scenografa nominirao je Gran Torino za svoju glavnu nagradu.

Izvori

Vanjske poveznice
Službena stranica

Američki filmovi 2000-ih
Dramski filmovi
Filmovi Clinta Eastwooda


text:
King Kong Lives
1986 American monster film directed by John Guillermin
King Kong Lives also known as King Kong 2 in other countries, is a 1986 American action-adventure fantasy monster movie directed by John Guillermin, and starring Brian Kerwin and Linda Hamilton. It was released in December 19, 1986. It is the sixth King Kong movie, as well as the sequel of the 1976 movie.
John Guillermin
Martha Schumacher
Ronald Shusett
Brian Kerwin
Peter Michael Goetz
Malcolm Cooke
De Laurentiis Entertainment Group
Shochiku (Japan)
De Laurentiis Entertainment Group (United States)
Paramount Pictures (Canada)
December 19, 1986 (1986-12-19) (United States)
$18 million[1][2]
$48.9 million (est.)[1][2]
3 Critical response
4 Box office
6 Other websites
PlotEdit
After being shot down from the World Trade Center, Kong is revealed to be still alive and is kept in a coma for about 10 years at the Atlantic Institute, under the care of surgeon Dr. Amy Franklin. In order to save Kong's life, Dr. Franklin must perform a heart transplant and give Kong a computer-monitored artificial heart. However, he has lost so much blood that a blood transfusion is badly needed, but Franklin says there is no species of ape or other animal whose blood type matches Kong's.
Hank "Mitch" Mitchell, adventurer and Franklin's eventual lover, who travels to Borneo (as he theorizes that Borneo and the island from the first movie were once part of the same landmass) and captures a giant female ape who is named "Lady Kong". Mitchell brings her to the institute to use her blood for King Kong's surgery. The transfusion and the heart transplant are a success, but Kong escapes along with Lady Kong.
Archie Nevitt, an insane army lieutenant colonel, is called in with his men to hunt down and kill the two apes. Lady Kong is captured alive by Nevitt's troops and imprisoned; Kong falls from a cliff and is presumed dead. However, as Franklin and Mitchell soon discover, Kong's artificial heart is beginning to fail, forcing them to attempt a jailbreak. They discover that Lady Kong is pregnant with Kong's offspring. The jailbreak is successful thanks to Kong, who has survived the fall and breaks his mate out. After being followed, attacked, and shot by the military, Kong kills Lt. Col Nevitt and dies slowly near a military base on a farm where Lady Kong gives birth to an infant son. Kong reaches out to touch his son just before dying. Having returned to Borneo, Lady Kong lives peacefully with her son in the jungle.
CastEdit
Brian Kerwin - Hank Mitchell
Linda Hamilton - Amy Franklin
Peter Elliott - King Kong
George Antoni/Dee Dee Rescher - Lady Kong
Benjamin Kechley/Billy West - Baby Kong
John Ashton - Colonel Archie Nevitt
Peter Michael Goetz - Dr. Ingersoll
Frank Maraden - Dr. Hughes
Jimmy Ray Weeks - Major Peete
Andrew Hughes - United Nations journalist
Michael Forest - Vance
Leon Rippy, Wallace Merck, Dean Whitworth, Herschel Sparber - Hunters
Critical responseEdit
King Kong Lives was criticized by movie critics and the reviews were very negative. Rotten Tomatoes reported that none of the movie critics gave the movie a positive review, which has an average rating of only 2.20 out of 10.[3] On Metacritic, the movie has an average score of 32 out of 100 based on 9 reviews by movie critics, meaning "generally unfavorable reviews".[4]
Box officeEdit
Across the world, King Kong Lives was a commercial success at the box office, with a total revenue of $48.9 million, which was much more than the movie budget of $18 million.[1][2]
It was a box office bomb in the United States and Canada,[5] grossing $4,711,220 during its theatrical run.[6] But the movie's success elsewhere, covered the losses in North America.
↑ 1.0 1.1 1.2 Friendly, David T. "De Laurentiis rejoins the ranks" Los Angeles Times (November 16, 1985)
↑ 2.0 2.1 2.2 De Laurentiis PRODUCER'S PICTURE DARKENS: KNOEDELSEDER, WILLIAM K, Jr. Los Angeles Times 30 Aug 1987: 1.
↑ "King Kong Lives (1986)". Rotten Tomatoes. Fandango Media. Retrieved February 18, 2021.
↑ "King Kong Lives Reviews". Metacritic. Red Ventures. Retrieved April 5, 2020.
↑ Mathews, Jack (1986-12-24). "'Kong Lives' Dies At Box Office". Los Angeles Times. Retrieved 2012-06-10.
↑ "King Kong Lives (1986)". Box Office Mojo. 1988-07-05. Retrieved 2012-06-17.
King Kong Lives on IMDb
Retrieved from "https://simple.wikipedia.org/w/index.php?title=King_Kong_Lives&oldid=7748584"
This page was last changed on 30 August 2021, at 13:48.


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Welcome to this fantastic collection of 50 colour by number maths puzzles! The rules are simple; you must colour each cell that is a multiple of the number given in the star.
These puzzles are great for those wanting to advance their multiplication skills, or even adults looking for some relaxing and calming colouring!
A handy introduction page, featured inside, will help to explain the instructions in more detail. A multiplication chart is also included.
Solutions showing what the finished image should look like are towards the back of the book, so if in any doubt, take a peek there. Some of the images featured include animals, beach scenes, mythical creatures and many more. Can you tell what they may be before completing the puzzle?
All puzzles are printed on very high quality paper, meaning these pages can take plenty of colour!


text:
Shmaryahu Hoz  (Hebrew: שמריהו הוז) (born 1945) is a Professor Emeritus specializing in physical organic chemistry and computational nanotechnology.

Biography
Shmaryahu Hoz was born in Jerusalem in 1945.  He received a B.Sc. in Chemistry and Physics and an M.Sc. in Chemistry from the Hebrew University. He received his Ph.D. in Chemistry from Bar Ilan University and did post-doctoral studies at the University of California, Santa Cruz with Prof. Joseph F. Bunnett.
He joined the Chemistry Department at Bar Ilan University in 1975. His major research areas are: physical organic chemistry, the chemistry of SmI2, computational nanotechnology and the effects of electric fields on structure and reactivity.

Administrative activities
Professor Hoz has held several administrative positions at Bar Ilan University. He served as the Head of the Department of Chemistry and subsequently as Vice President for Research of the University. In his capacity as a VPR, he established the brain research center and set in place the foundations for the School of Engineering. For many years, Professor Hoz was in charge of the parliamentary aspects of the Board of Trustees of the University and headed the By-Laws Committee of the Senate of the University.

He currently serves as senior advisor to the university president and the head of the Responsa Project.

Scientific activities
His major scientific achievements are: the discovery of the catalytic effect of fluoride ion;
the discovery of the zwitterionic bicyclobutane;
the formulation of the leading theory on the origin of the α-effect;
the relationship between nucleophilicity and the Periodic Table;
the discovery of a molecule forty times harder than diamond in one dimension;
the first discovery of a molecule having a negative Poisson's ratio;
the formulation of guidelines and methods for the use of SmI2 in organic reactions.

References

External links

1945 births
Living people
Academic staff of Bar-Ilan University
Israeli chemists
Jewish chemists
Hebrew University of Jerusalem alumni
Computational chemists


Acetylene torches are used to cut, weld, braze, heat, bend and silver-solder metals. It's a very versatile tool with different torches for the different activities. Training is required to use the torch as there are many dangers, including high pressures, temperatures and the potential for explosion.
Cutting Torch - The acetylene cutting torch consists of a hose connection for acetylene, a hose connection for oxygen and shutoff valves. The torch itself has a separate passage for oxygen and acetylene. These two gases will mix in the mixing chamber of the torch and then flow out the cutting tip. There are many different cutting tips. The main difference between the cutting tips is the ability to cut through metals of different thickness. The cutting torch works by burning through metal in a rapid oxidation reaction. The metal doesn't actually melt.
Welding Torch - The welding torch's function is to bind two metals together. The weld forms when the two pieces of metal are heated to a temperature where the metals create a shared pool of molten metal. This shared pool is created with the help of a metal filler. The type of metal used as the filler depends on the metals being welded. The welding tip contains one hole. The larger the hole on the tip, the thicker the metal that can be welded. There are two valves at the bottom of the welding torch to adjust the flow of acetylene and oxygen.
Injector Torch - The injector torch is a pressure-dependent torch. There are low-pressure and medium-pressure injector torches. The torch has a pressure of 1 lb. per square inch or less. The pressure of oxygen as it moves through the torch produces enough suction to draw the acetylene into the mixing chamber. The injector head is a genera- purpose tool that's used for different functions.
Rosebud Torch - The rosebud torch is used to bend or straighten metal. It's used over large areas of metal. The name rosebud relates to the shape of the flame at the tip. Instead of one opening, the rosebud torch has a number of small holes. This is the most difficult acetylene torch to use as it's difficult to keep the gas flows steady. Rosebud torches require a large acetylene supply. The larger the tip, the greater the acetylene needed to keep it working.
What is The Appeal of Tungsten Parts & Fittings?


text:
Q: How to disable sideMenu on current window How to disable sideMenu on current window even user swipe right or left on the screen
Environment

*

*React Native Navigation version: 2.0.2106

*React Native version: 0.52.2

*Platform(s) (iOS, Android, or both?): both

*Device info (Simulator/Device? OS version? Debug/Release?): all

A: You can achieve it by setting the following configuration,
Navigation.push(this.props.componentId, {
  component: {
    name: screen,
    options: {sideMenu: {left: {enabled: false}}},
  },
});

A: Try setting navigationOptions of that page by adding the following code to the Component code.
static navigationOptions = {
  drawerLockMode: 'locked-closed'
}

More detailed explanation can be found in the below linked SO answer
https://stackoverflow.com/a/45160191/6435908


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after release from custody, prisoners who have anxiety and depression are more likely to be reconvicted than those who do not. Mindfulness-Based Interventions (MBIs) have been used in a number of small pilot projects in the UK, and in the US there has been some early research which indicates its potential for reducing violence in prisons and re-offending rates. Wider research into mindfulness also points towards its potential to address a number of psychological processes and states that are relevant to risk of recidivism.


text:
Home / News / Clinical Eye Care / Health and Wellness / Recharging the retina
Can red light recharge the retina?
With the retina aging quicker than other organs in the body, due to the high concentration and decline of mitochondria in photoreceptors, researchers in a new study took a fresh look at improving mitochondrial function.
A simple red light a few minutes a day may stop the normal decline of eyesight in adults over age 40, a new pilot study says.
With the retina aging quicker than other organs in the body, due to the high concentration and decline of mitochondria in photoreceptors (light-sensitive rods and color-sensitive cones), researchers in a new study took a fresh look at improving mitochondrial function. The study was published June 29 in the Journals of Gerontology: Series A.
Researchers, primarily affiliated with University College London (UCL), looked at whether brief, daily exposure to 670 nm light devices over a two-week period could significantly improve retinal function in 24 study participants. Ranging in age from 28 to 72 years old, they were divided into two groups: one measuring rod thresholds and the other color contrast sensitivity. Participants were healthy with no eye or systemic diseases.
Subjects were then asked to shine the deep red beam of the light devices (ten 670nm LEDs) daily for two weeks on their dominant eye each morning for three minutes.
The researchers' findings, compared to participants' baselines? Older study subjects showed improved photoreceptor function after the exposure.
In the tritan (blue visual) axis, color contrast sensitivity increased significantly for participants over age 40 compared to younger subjects by an average of 20% with a maximum of 47%.
Among the total group (ages 28 to 68) there was a significant improvement (14%) in tritan thresholds after exposure, researchers reported.
Protan (red visual axis) thresholds showed no change after 670-nm exposure in the younger group but improved by about 10% in the older subjects, though this finding was deemed not statistically significant by researchers.
Improved sensitivity of scotopic (rods) thresholds was found in 8 of 12 subjects, three of them under age 40.
"Using specific wavelengths to enhance mitochondrial performance will be significant in moderating the aging process in this metabolically demanding tissue," say the researchers, noting that further research is needed.
Lead author of the study, UCL Professor Glen Jeffery, likened the results of the red-light exposure to "recharging a battery" in a university publication.
Small study, big curiosity
Karl Citek, O.D., Ph.D., chair of the AOA's Commission on Ophthalmic Standards, notes the study's small size (24 healthy participants) and its lack of improvement in younger participants.
"Finally, there may not be any benefit for patients who already have retinal disease, two of the most common being diabetic retinopathy (DR) and age-related macular degeneration (AMD)," says Dr. Citek, who practices in Oregon and teaches at the College of Optometry at Pacific University. "The authors state that clinical trials with DR and AMD patients have begun, but that another group recently published a pilot study of AMD patients showing no benefit to red light exposure."
Still Dr. Citek found the study interesting. According to the University College London study, 30% of central rods die and cones have reduced function by 70 years of age. If the therapy can improve vision in individuals over 40, it's worth further study.
"It's nice to see there were changes in a short time period, but there's no evidence to date to show the impact if it's done for longer periods, or that it can be used as a preventative measure by anyone under 40," Dr. Citek says.