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dClock (clk) is a gene located on the 3L chromosome of Drosophila melanogaster. Mapping and cloning of the gene indicates that it is the Drosophila homolog of the mouse gene CLOCK (mClock). The Jrk mutation disrupts the transcription cycling of per and tim and manifests dominant effects.

Discovery
Discovered at Brandeis University in 1998, cloning the mutant Jrk led to the identification of the drosophila homolog of the mammalian Clock gene in DNA.

Jrk mutation
Jrk is a mutation of a gene (not to be confused with JRKL ) discovered by Michael Rosbash and his colleagues in 1998. A common misconception is that the Jrk mutant gene is the Drosophila homolog of CLOCK (mClock), which disrupts cycling transcription of the per and tim genes. The Jrk mutation was discovered before dClock, but it is a mutation of dClock. Jrk is a semi-dominant third chromosome mutant displaying arrhythmic, or not rhythmic, locomotor behavior in constant darkness. It's been found that Jrk mutant flies are less robust to changes in the environment, such as temperature increases, than animals with the wild type dClock gene. The mutant flies also have differing light sensitivity and behavior patterns, suggesting that dClock is important in controlling coupled oscillators. The mutation in dClock that makes Jrk is from a premature stop codon that truncates the protein, deleting most of the putative C-terminal activation domain of the bHLH-PAS transcription factor. This is consistent with the mammalian clock mutant phenotype.

Structure
Through complementation testing of Jrk with various deletions done by Allada et al., Jrk was found to be located on the left arm of chromosome 3, specifically at location 66A10-22.

Start site: 7,763,233

Stop site: 7,775,603

The dClock gene has a PAS domain between positions 90-156, and positions 255-321. These regions are important for allowing proteins to recognize and associate with one another, forming dimers. This is followed by a C-terminal PAC motif starting at position 327 and ending at 370. PAC motifs have been proposed to contribute to the PAS domain fold.

The gene also has a bHLH domain starting at position 21 and ending at position 71. This means that it binds specific DNA sequences, the E-box consensus sequence in this case, that regulate transcription. This domain is a 60 amino acid region with a DNA binding domain, which is followed by two amphipathic alpha-helices which are connected by a loop, forming the HLH motif. This region is also important in protein dimerization, which is necessary for DNA binding.

The gene has 5 transcripts, which encode for 4 unique polypeptides. It has 9 exons. The transcript of the gene is about 5000kB long, as determined through utilization of northern blot techniques. The polypeptide that the transcript encodes for has a reported size between 1015 and 1027 amino acids, and a molecular weight between 130 and 150kD.

Function

Circadian clock
In Drosophila, there are two main players in the generation of circadian rhythms: the period (per) gene and timeless (tim). These two genes are responsible for the oscillations in protein levels, RNA levels, and transcription rates that occur in flies.

Another essential component of this circadian clock mechanism is that the PER protein contains a PAS domain, which has been demonstrated to mediate the interactions between transcription factors. These transcription factors also contain the well-characterized basic helix-loop-helix (bHLH) DNA-binding domains. Furthermore, in mice an E box (CACGTG) was discovered, which acts a binding site for some of the bHLH transcription factors, which includes bHLH-PAS transcription factors.

Jrk mutant phenotypes
The mutant Jrk allele is a consequence of a point mutation, which is simply the insertion, deletion, or swapping of one nucleotide base in an mRNA sequence for another. This mutation exhibits a dominant negative effect, meaning that just one copy of it is enough to produce phenotypic deviation. The Jrk mutation deletes much of the gene that encodes for the glutamine (Q)-rich C terminus of the protein. This region is involved in transcriptional activation, which is necessary to allow mRNA to be transcribed from DNA in the nucleus. It can be achieved by utilizing ethyl methanesulfonate (EMS) as a mutagen. The mutation results in a cytosine being swapped for a thymine at the 7764959 position (C7764959T). This substitution causes what was initially encoded as a glutamine to be swapped for a premature stop codon, preventing further translation of the gene.

Jrk was identified as a homozygous mutant with completely arrhythmic locomotor behavior in constant darkness. Approximately half of all of the Jrk heterozygotes were arrhythmic, and those that did manifest a rhythm had a slightly longer period than the wild-type controls.

Researchers also observed that both PER and TIM levels are extremely low and non-cycling in homozygous Jrk flies, approximately equivalent to the trough levels of wild-type flies. In heterozygotes, PER and TIM cycle well, but the amplitude is reduced by approximately 50%, consistent with the clear effects on behavioral rhythmicity in these flies.

Mammalian homologs of dClock
The Jrk gene has a myriad of homologs throughout the natural world, with 642 orthologs and 3 paralogs. Mammal circadian systems contain the Clock gene which has been shown to be closely related to dClock. Both have strikingly similar bHLH domains, which suggests that they associate with similar, if not identical, DNA targets. The PAS region is also highly conserved between drosophila and mice. This suggests that both Jrk and its mouse homolog have conserved heterodimeric partners.

Mammalian mutations in the Clock gene have been found to result in autism spectrum disorder, schizophrenia, attention‐deficit/hyperactivity disorder, major depressive disorder, bipolar disorder, anxiety disorder, and substance use disorder.

See also
 Clock gene
 Period (gene)
 Cycle (gene)
 Timeless (gene)
Chronobiology
 Oscillating gene
 Michael Rosbash
TTFL

References

External links

Drosophila melanogaster genes


text:
The evolution of Parliament
Changes in legislative authority
Act of Union 1707
Union between Scotland and England?
Union of the Crowns
Revolution and civil war
Negotiations for Union 1702 - 03
The Scottish Parliament in revolt 1703
Westminster passes the Alien Act 1705
Negotiating the Articles of Union 1705 - 1706
The 1706 negotiations
The Articles, constitution and trade
Ratification, October 1706 - March 1707
Westminster debates the Articles
Mob unrest and disorder for Scotland
End of the old Scottish Parliament
Thanksgiving and lament
United into One Kingdom
The 1715 rebellion
Britain and the wider world
The idea of a union between England and Scotland was aired in February and March 1689 during the deliberations of the Convention Parliament in Edinburgh. William III wrote to the Convention of his pleasure that so many of the Scots nobility and gentry favoured the proposal, especially since both nations shared the same landmass, language and attachment to the Protestant religion.
It would also, of course, help to secure the Revolution against ex-King James and the Jacobites.
As a result of this encouragement, the Convention appointed commissioners to negotiate with the English but met with a wall of disinterest.
A proposal for union was made in the Lords in 1695, but that, too, received short shrift.
In Scotland, however, the case for union found much favour among the political elite during the 1690s, mainly because of the poor state of the economy.
In 1699, there were discussions between politicians in London and Edinburgh and the English side acknowledged that a union might be in both nations' interest. The Scots hoped for a union of trade with vital access to English colonial markets.
Bill proposed
By early 1700 these talks had hardened into a legislative proposal backed by the King. At Westminster a bill for negotiating a union passed the Lords, but was thrown out by the Commons.
This example of continuing English inflexibility did little to dispel the intense anti-English attitudes that were rife in Scotland.
Next in line to the throne
The Bill of Rights in 1689 had declared that William and Mary would be succeeded by Mary's sister Anne, but it made no provision for the succession if Anne died childless.
William and Mary had no children, but the birth to Anne of a son - Prince William, the Duke of Gloucester - seemed to make the succession safe. But his death, aged 11 in 1700, changed that.
Westminster decision
The English Parliament at Westminster eventually declared in the Act of Settlement 1701 that after Princess Anne - James II's younger Protestant daughter - the succession would pass in the Protestant line to Sophia of Hanover and her heirs.
The Scottish Parliament chose to do nothing and it seemed as if they might well offer the Scottish crown to the exiled Stuarts.
Convention Parliament
A parliament not summoned by the monarch.
Darien scheme
The name of an unsuccessful attempt by Scotland to establish a colony called New Caledonia, in Panama, Central America in the 1690s
Jacobites
Supporters of the claim to the throne of James II, who abdicated in 1688, and his Stuart descendants, the 'Old Pretender' James Edward Stuart and the 'Young Pretender' Bonnie Prince Charlie. 'Jacobus' is Latin for James.

redpajama_set_name: RedPajamaCommonCrawl


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Nestor Schor (São Paulo, 9 de dezembro de 1946 — 3 de fevereiro de 2018) foi um médico, pesquisador e professor universitário brasileiro.

Comendador da Ordem Nacional do Mérito Científico, membro titular da Academia Brasileira de Ciências e da Academia Nacional de Medicina, Nestor foi professor titular e livre-docente da Universidade Federal de São Paulo (Unifesp). Sua pesquisa estava voltada para a hemodinâmica glomerular e microcirculação renal, fisiopatologia renal, insuficiência renal aguda, litíase renal, nefrotoxicidade, infecção urinária, produtos naturais, biologia celular e molecular de células mesangiais glomerulares e células-tronco e rim.

Biografia
Nestor nasceu na capital paulista, em 1946. Era filho de Hirsch Schor, médico romeno e de Tuba Laser Schor, ambos radicados no Brasil. Ingressou no curso de medicina da Escola Paulista de Medicina (EPM) da Universidade Federal de São Paulo, onde se formou em 1972. Fez residência médica em nefrologia entre 1974 e 1975, defendendo o doutorado em nefrologia em 1977, também pela Unifesp.

Em 1978 realizaria estágio de pós-doutorado pela Escola de Medicina Harvard e em 1993 pela Universidade de Cornell. Em 1989 tornou-se livre-docente pela Unifesp e três anos depois tornou-se professor titular no departamento de medicina da Unifesp, onde ministrou disciplinas como Rim e Hormônios, Litíase Renal, Fisiologia e Fisiopatologia e Infecção do Trato Urinário.

Foi pioneiro ao implantar no país um laboratório voltado para o estudo da hemodinâmica glomerular e microcirculação renal em modelos experimentais de insuficiência renal aguda e crônica, de nefrotoxicidade, na síndrome hépato-renal, na gravidez e etc. No começo da década de 1990 criou o Laboratório de Biologia Celular, voltada para o estudo destes mecanismos fisiopatológicos nas células renais, agora em cultura, especialmente na célula mesangial. Desenvolveu também o primeiro serviço voltado a estudar o metabolismo envolvido na formação de litíase renal tanto em adultos como em crianças.

Foi Chefe do Departamento de Medicina (1996-99) e Chefe da disciplina de Nefrologia (1999-2000). Foi Pró-Reitor de Pós-Graduação e Pesquisa da Unifesp (2002-2008). Desenvolveu diversos projetos de pesquisa, incluindo fisiopatologia renal, litíase urinária, biologia celular e células-tronco em nefrologia e foi presidente da Fundação Oswaldo Ramos/Hospital do Rim e Hipertensão (2004-2006).

Morte
Nestor morreu em 3 de fevereiro de 2018, na cidade de São Paulo, aos 71 anos.

Homenagem
Em 14 de dezembro de 2019, o Edifício de Pesquisa II do campus da capital da Universidade Federal de São Paulo passou a se chamar Edifício de Pesquisa Profº Dr. Nestor Schor.

Alunos da Universidade Federal de São Paulo
Brasileiros de ascendência romena
Cientistas do Brasil
Judeus do estado de São Paulo
Judeus asquenazes
Médicos do Brasil
Membros da Academia Nacional de Medicina
Naturais da cidade de São Paulo
Ordem Nacional do Mérito Científico
Professores da Universidade Federal de São Paulo

redpajama_set_name: RedPajamaWikipedia


text:
Gravesend Reporter
Government scraps proposal for new Thames crossing in Swanscombe
Joshua Fowler
The Dartford Crossing
One of the three proposed options for a new Lower Thames crossing has been scrapped by the government.
This map, from the Department for Transport, shows the proposed Thames crossings.
Option B, which would have seen the A2 Swanscombe Peninsula connected with the A1089, in Tilbury, has been discarded by the Department for Transport - who will now choose between Options A and C.
Option A would see the development of the existing A282 Dartford-Thurrock crossing, while Option C would connect the M2 with the A13 and M25 between junctions 29 and 30.
There is also a variant to Option C, which would widen the A229 between the M2 and M20.
A consultation, launched in May, sa Option B receive limited support and found that the proposal would frustrate development in the area.
Dartford MP, Gareth Johnson, says he is "delighted" after vehemently opposing both Option A and B.
He added: "This will be welcome news for local residents and for developers who are keen to make a significant investment in that area.
"The government has recognised the huge potential that exists in Swanscombe and the potential for jobs and the future economic benefits for the Dartford area.
"People in Dartford are fed up with the misery that the Dartford crossing has given them over many years. We don't want another crossing in this area and this decision does at least rule out one of the locations where we could have had an additional crossing."
The government will carry out further work to understand the possible impacts on the local areas of the remaining options.
In the meantime, they remain set on introducing 'free flow' charging at the Dartford crossing from October next year. This will see the removal of toll booths, with drivers able to pay remotely, similar to the congestion charge in London.
The dispute that tore a nation apart
Driver who ran over a woman twice is jailed for 10 years
Labour leader Ed Miliband visits Gravesend in final push for votes
Greenhithe man Sam Dunne jailed for Gemma McCluskie sex assault and kidnap calls
Get ready to celebrate the year of the rat in Gravesend
Latest from the Gravesend Reporter
Dartford woman's year of sport in memory of Mottingham brain tumour victim
Witness appeal as teenage girl robbed at Greenhithe station
Classic thriller Dial M for Murder comes to the Orchard Theatre


Since I nabbed the new Colorbar MesmerEyes Kajal around a month ago it's barely left my eyes. Of course there's the odd competing formula that gets an application, but for the month of November the MesmerEyes Kajal has reigned supreme as my eye kajal of choice. The question on everyone's lips has been 'Why?' so I thought I'd get down to the nitty gritty and give you lot the low-down on the good, the bad…and for once there's no ugly.
Tools and brushes have their place, but sometimes you just can't beat getting down and dirty into makeup with your tips and palms. Easier to spread, easier to blend and it's like your very own makeup hotplate and mixer at your hands. Literally. I've been finding more and more recently that I've been getting rather handsy in my application; not just directly but smooshing products on the back of my hand before, to heat them slightly and get the formulas face-ready before mine has even got anywhere near it. Now not all products require this step but I've taken notes on some of my favourites that benefit from this additional 'hand palette' treatment.


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20. mistrzostwa świata w łyżwiarstwie szybkim w wieloboju odbyły się w dniach 17–18 lutego 1912 roku w stolicy Norwegii, Oslo. Zawodnicy startowali na naturalnym lodowisku na Gamle Frogner Stadion po raz trzeci (wcześniej w 1904, 1909). W zawodach wzięli udział tylko mężczyźni. Łyżwiarze startowali na czterech dystansach: 500 m, 1500 m, 5000 m, 10000 m. Po raz trzeci mistrzem został Norweg Oscar Mathisen, który pobił także dwa rekordy świata – na 500 m i 10000 m. O tym, które miejsca zajmowali zawodnicy decydowała mniejsza liczba punktów. Liczba punktów była identyczna z miejscem zajętym w danym biegu (1. miejsce – 1 punkt, 2. miejsce – 2 punkty itd.).

Uczestnicy
W zawodach wzięło udział 15 łyżwiarzy z 3 krajów. Sklasyfikowanych zostało 9.

Wyniki
 DNF – nie ukończył, DNS – nie wystartował, WR – rekord świata

Linki zewnętrzne
 Wyniki na stronie Schaats Statistieken.nl

Mistrzostwa świata w łyżwiarstwie szybkim w wieloboju
1912 w sportach zimowych
1912 w Europie
Norwegia w XX wieku
Łyżwiarstwo szybkie w Norwegii
Sport w Oslo


Premier Nationwide Lending is a mortgage lending company run by top industry professionals. We are a Family Oriented Company that all work towards the common goal of helping people to accomplish the American Dream of Homeownership. Our company has been built on the foundation of Family Values, Work Ethic, Respect, Flexibility and Experience. If you feel you are a match to join our team, please contact us today about your career future or visit www.jointeampremier.com for more information.
Premier Nationwide Lending is a mortgage lending company run by top industry professionals. We are a Family Oriented Company that all work towards the common goal of helping people to accomplish the American Dream of Homeownership. Our company has been built on the foundation of Family Values, Work Ethic, Respect, Flexibility and Experience.
Since 2002, Premier Nationwide Lending has grown into a $2 billion a year mortgage lending institution. Our service-oriented structure is setup with the ability to double this in the near future. Our staff is made up of many top producers in the mortgage lending market that know they need a company like Premier Nationwide Lending to get their loans closed on time and satisfy their customers needs. We do this time after time, loan after loan. This is our rule, not the exception.
We are expanding into new states and new markets on a regular basis. We are currently licensed in 21 states and are actively growing our presence and footprint in all of them. We currently have 30 standalone mortgage lending offices and our main office is located in Lewisville, Texas.
You will hear us talk about FAMILY a lot here at Premier Nationwide Lending. This is the culture that we have created to foster the relationships and friendships that have gotten us to where we are today. A mortgage company like Premier Nationwide Lending is very hard to find in this ever-changing business that we find ourselves in. Don't take our word for it though. Come see for yourself!!!


How to clean ears safely.
Hold stem firmly 12mm from tip and gently clean outer surface of ear. Under no circumstances should this product be inserted into the ear canal. This can lead to ear drum damage, obstruction and infection developing.


March 28, 2019 - Dark ruby. Blossoming aromas of game, roses, black pepper, coffee, and dry heath. Gritty tannins on the palate, with a pure sweet clear fruit core shining through, framed by girders of tannin and acid, with a lovely floating aromatic back note above the lingering finish of sparkling acid under polished tannins. A remarkable wine, probably way too young, looking forward to tasting years from now, excellent with ratatouille. 50 + 17 + 18 + 9 = 94.
March 19, 2019 - Tasted side by side with the '15 Balthazar Chaillot - this comes off as more polished. It has dark fruits, black olive tapenade and fine tannins - still very young but approachable now.
March 19, 2019 - Revenge of the Cornas (Michaeangelo Hotel): Nice start to the tasting. This is classic Cornas. Lots of lovely dark black fruits and a bit of a more gentle note (which I think is how I interpret the acidity in these wines). Very fine tannins. Tasty.
October 27, 2018 - 2015 Northern Rhones Blind: Decidedly corked.
October 27, 2018 - Most of the 2015 Northern Rhones worth a damn, blind (Chicago, IL): Corked.
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Other vintages for this wine 2017 2016 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1991 1990 1989 1988 1986 1985 1982 1981 N.V.


Lakers Updater is creating a way to win Lakers tickets and merch!
Welcome to Lakers Updater Patreon page. This is the only place where you can spend as little as $2 a month and win actual Lakers tickets and merch! Not from L.A.? Don't worry! We can get you Lakers tickets wherever you live. For example, if you live in New York, we will get you Lakers vs Knicks tickets!


text:
Huawei Nova 5i Pro Specs Got Leaked
Asus ROG Phone 2 Surfaced On TENAA With Massive 5,800 mAh Battery
Xiaomi Mi A3 Asian Debut Will Take Place On July 31
Infinix S4 Review-Delivers the best performance under Rs.22,999/- Only
Government of Pakistan is Truly Committed to Digitalize Pakistan & Promote IT
Asad Raza Last Updated: Dec 21, 2018
Federal Minister for Information Technology and Telecommunication Dr. Khalid Maqbool Siddiqui has said that it is the topmost priority of the government to digitalize Pakistan. The Federal Minister was chairing the first meeting of Prime Minister Taskforce on IT and Telecom at the committee room of the Ministry of IT on Thursday.
GOVT of Pakistan is Truly Committed to Digitalize Pakistan & Promote IT
Secretary Ministry of IT Maroof Afzal was also present in the meeting. Dr. Atta-ur-Rehman attended the meeting as co-chairman of the PM Taskforce on ITand Telecom.
The Federal Minister said that penetration of fiberization, broadband, mobile phones and smartphones will be enhanced across the country.
He said that the present government is committed for promotion of information technology in the country. We have to take Pakistan towards development and prosperity through information technology. The meeting decided to declare IT and Telecom sector as industry and to adopt legal process in this regard.
The meeting formulated with consensus three sub-task forces on IT, Telecom and Human Resource Development. These sub-task forces were directed to submitt their recommendations in six weeks time period.
Member IT Ministry of IT gave detailed presentation regarding the objectives and mandate of the Ministry of Information Technology and Telecommunication. The members of the taskforce also discussed different issues and challanges confronted by IT and telecom sector in the country.
Speaking on the occasion, Dr. Atta-ur-Rehman emphasised upon making our IT industry comply with international standard.
He said that innovation and entrepreneurship must be promoted in the IT sector. The taskforce was also briefed about different programs launched by Ministry of IT including Digiskills, ICT for Girls through Technology, National ICT Scholarship program etc.
The meeting was told that five national incubation centers have been established in different cities under Rollingout National Network of Incubators project.
Asad Raza


Perfect small houseboat for dawdling around the delta. Nothing fancy but clean and ready to go for a night or a few days.
This 39' Hudson has just finished going thru a nice face lift. She is a single diesel with a large aft master stateroom and a v berth forward, each with their own head.
Custom built replica of 19th century Swedish launch designed by Alfred Steam Ship.
Single diesel, Build was completed at Ladd's Marina of Stockton.
Exceptionally clean one owner boat with 260 hp Merc I/O with full delta canvas on a tandem axle trailer with brakes.
This is a very nice Century Coronado 21 that had Ford 310 engine rebuilt in 2000 and also had in water part of bottom fiber glassed. Has column shifter for transmission. Full boat cover and bomini top.
Original hardtop is included with sale.


text:
Rollover crash briefly shuts down Eastern Street in New Haven
June 29, 2015 Updated: July 24, 2017 10:39 p.m.
Emergency responders work to clear a rollover crash Monday morning near the Bella Vista apartments on Eastern Street in New Haven. One person was hurt in the accident.Wes Duplantier/New Haven Register
NEW HAVEN >> A woman was taken to the hospital by ambulance after a rollover crash on that shut down Eastern Street in front of the Bella Vista apartments Monday morning.
Eastern Street was shut down shortly around 9:20 a.m. after the crash, in which a Subaru sedan appeared to have hit a black Dodge Journey SUV. The subaru rolled on its side, trapping the driver.
The Dodge had been parked along the curb in the southbound lane of Eastern Street near the entrance to Bella Vista.
No one was inside the SUV, which sustained minor damage.
Firefighters worked for about 10 minutes to free the driver of the Subaru, cutting through the roof of the car.
"It was a pretty quick extrication," Acting Fire Battalion Chief Mark Vendetto said at the scene. "The guys did a great job."
The woman inside the Subaru was taken to the hospital with apparent minor ijuries.
New Haven resident Brian Mossman, who lives near the scene, was driving up Eastern Street when he came upon the crash.
Mossman, whose brother works in the apartment complex, said it's not unusual for nurses or other staff caring for people at Bella Vista to park along the curb of Eastern Street, a fairly busy two-lane road.
"They park there sometimes and take care of the elderly people up there," he said, indicating the apartments.
The wreck was cleared and Eastern Street was reopened after about an hour. Police were investigating the crash late Monday morning.


It's the last Wednesday...err..Tuesday of the month which means I'm linking up with Shay, Mel and Sheaffer for What's Up Wednesday.
Mr. and I are on day 15 of the 21 day fix, so all of our meal prep happens on Sundays right now. Like these egg cups, which I realized about day 8 that I detest them and couldn't eat one more bite.
Baby Fox graduated from preschool on Friday. 100° heat with an outdoor performance...at least it was somewhat shady, so that was good. But it was so hot! The kids were adorable. I just remember that little kid, scared and crying the first couple of drop offs, to the point where he just wants to jump out of the car barely waving good bye.
Summer and swimming! So happy that Mini Fox is somewhat water safe, I mean she probably has a 50/50 chance at least, better than no chance at all. But she's loving being able to "swim" and we're all just sto stinkin proud of her. And then Baby Fox is just rocking at his swim lessons, like I can't even believe how much better he has gotten in the 5ish weeks we've been going.
My Mother-In-Law was in town this past weekend to watch Baby Fox graduate. He was so excited that she was here and loved every minute of the attention. Thank you Grandma for coming to visit us and spoiling us! Can't wait for September!
Baby Fox starting Kindergarten. This is the real deal guys. I mean no more just not sending him to school because I want to. I guess I could, but lying is just not my thing, at least it's only 3 hours a day. But next year...it's really on, real school, for the next 12 years, yikes!
Mini Fox's birthday invites for September! I can't believe it's almost August, I need to get on these invites! She told me she wants an Arial party...no problem!
Going up to Big Bear in a few weeks, so excited to just spend some time relaxing and hanging out with friends.
We just finished watched Game of Thrones and we've gone back to watch Sons of Anarchy...man a day in their life is crazy! Like seriously, how can this much happen to one group of friends, yikes! Well they do dabble in crazy stuff, but really, it's one thing after another.
And I actually read something this week! Mr. was on a business trip a couple of weeks ago so I took the down time to read Me Before You...so good! I wanted to read it before seeing the movie, but I was too late, by the time I finished, I wanted to go see it, but they only have showings while I"m at work. Darn, guess my mom and I will have to wait until it comes out on DVD.
Not much actually...isn't that sad?
Summer clothes! The heat has finally hit us, and I'm all about swing dresses and comfort!
We are off to Legoland to celebrate my cousin's kids birthday! So excited to spend some time with the cousins and spend the night at the Legoland Hotel. In case you have missed it I did a whole review on Legoland (Hotel Review, Must See Things, Things to Skip).
Not being on the 21 day fix! haha...just kidding, sort of, but really next month is my birthday! I'm looking forward to seeing friends and just enjoying the last bit of summer before Baby Fox starts Kindergarten, of course the day BEFORE my birthday, oh well, at least school starts late!


text:
--------------------------------------------- Toda...
Today is Sunday, May 9th.
The 130th day of 2004.
This is Mother's Day.
On May 9, 1754, The first American newspaper cartoon was published. The illustration, in Benjamin Franklin's "Pennsylvania Gazette", showed a snake cut into sections, each part representing an American colony; the caption read, "Join or die."
In 1502, Christopher Columbus left Cadiz, Spain, on his fourth and final trip to the Western Hemisphere.
In 1671, Irish adventurer Thomas Blood, known as Colonel Blood, is caught after stealing the crown jewels from the Tower of London; he is ultimately pardoned by King Charles II.
In 1899, The lawn mower was patented.
In 1913, The 17th amendment to the Constitution, providing for the election of U.S. senators by popular vote rather than selection by state legislatures, was ratified.
In 1914, The first Mother's Day was proclaimed by President Wilson.
In 1926, Americans Richard Byrd and Floyd Bennett became the first men to fly over the North Pole.
In 1936, Italy annexed Ethiopia.
In 1943, The 5th German Panser army surrenders in Tunisia
In 1945, U.S. officials announced that a midnight entertainment curfew was being lifted immediately.
In 1960, The Food and Drug Administration approved a pill as safe for birth control use. (The pill, Enovid, was made by G.D. Searle and Company of Chicago.)
In 1961, Federal Communications Commission chairman Newton N. Minow condemned television programming as a "vast wasteland" in a speech to the National Association of Broadcasters.
In 1963, A secret military satellite is launched by the Air Force from Point Arguello, Ca., releasing 400 million tiny copper hairs into a polar orbit to provide a cloud of reflective material for relaying radio signals from coast to coast within the U.S.
In 1970, 100,000s demonstrate against the Vietnam War in Washington, DC.
In 1974, The House Judiciary Committee opened hearings on whether to recommend the impeachment of President Nixon.
In 1978, The bullet-riddled body of former Italian prime minister Aldo Moro, who'd been abducted by the Red Brigades, was found in an automobile in the center of Rome.
In 1980, 35 motorists were killed when a Liberian freighter rammed the Sunshine Skyway Bridge over Tampa Bay, Fla., causing a 1,400-foot section to collapse.
In 1989, President G. H. W. Bush complained that Panama's elections were marred by "massive irregularities," and he called for worldwide pressure on General Manuel Antonio Noriega to step down as military leader.
In 1987, Actor Tom Cruise (27) weds actress Mimi Rogers (33).
In 1991, William Kennedy Smith, nephew of Sen. Edward Kennedy, D- Mass., was charged with the March 30 rape and assault of a woman at the Kennedy estate in West Palm Beach, Fla. He was later acquitted.
South Africa's newly elected parliament chose Nelson Mandela to be the country's first black president. Mandela promised a South Africa for "all its people, black and white."
A chartered bus carrying members of a casino club on a Mother's Day gambling excursion flipped off a highway in New Orleans, killing 22 people.
Furious Chinese demonstrators hurled rocks and debris into the U.S. Embassy in a second day of protests against NATO's bombing of the Chinese Embassy in Yugoslavia.
The United States and its allies asked the UN Security Council to give its stamp of approval to their occupation of Iraq.
The Republican-led House approved 222-203 a $550 billion tax cut package.
Louisiana Democrat Russell B. Long, who greatly influenced tax laws during nearly four decades in the Senate, died at 84.
In Cleveland, a camouflage-clad gunman fired hundreds of rounds as he roamed the halls of Case Western Reserve University's business school, killing one person; suspect Biswanath Halder later pleaded innocent.
CBS News correspondent Mike Wallace is 86.
Actor-writer Alan Bennett is 70.
Actor Albert Finney is 68.
Actress-turned-politician Glenda Jackson is 68.
Musician Sonny Curtis (Buddy Holly and the Crickets) is 67.
Producer-director James L. Brooks is 64.
Singer Tommy Roe is 62.
Singer-musician Richie Furay (Buffalo Springfield and Poco) is 60.
Actress Candice Bergen is 58.
Singer Clint Holmes is 58.
Actor Anthony Higgins is 57.
Singer Billy Joel is 55.
Rock singer-musician Tom Petersson (Cheap Trick) is 54.
Actress Alley Mills is 53.
Actor John Corbett is 43.
Singer Dave Gahan (Depeche Mode) is 42.
Rapper Ghostface Killah is 34.
Singer Tamia is 29.
Rock musician Dan Regan (Reel Big Fish) is 27.
Actress Rosario Dawson is 25.
"A mother never realises that her children are no longer children." -
- Holbrook Jackson, British critic and historian (1874-1948 ).


Hello! I was wondering if anyone knows if it is possible to put my membership on "pause"? I have used my bonds to purchase 5 months worth of membership since it was cheaper but now I wont be able to log on pretty much at all for the next 2-3 months. Can i pause the membership so i dont waste time while not playing or have I wasted my bonds?
I am really sorry but a membership 'pause' is not a feature offered by Jagex.
It is always a gamble buying membership too far in advance - the usual membership interval is one month.


Acne is a common skin condition and a source of embarrassment for many of those who struggle with it. Whether you're a teenager struggling with the constant blemishes, or an adult who is still bothered by the acne scars, it can be difficult to feel confident about your appearance if you're always worrying about covering up or trying to hide the affected areas of skin. Dr. Deborah Farrell can help treat your acne or acne scars and boost your self-confidence with laser acne treatment by CoolTouch™.
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text:
PARADISE '89
Madara Dislere
Director Madara Dislere
Producer Aija Berzina, Alise Gelze - Tasse Film; Bastei Media
Cast Magda Lote Auzina, Liva Locmele, Marta Ģertrude Auzane, Evelina Ozola, Inga Apine, Gatis Gaaga, Kaspars Gods, Ivars Krasts
Writer Madara Dislere
Camera Gints Berzins
Editor Heike Parplies
Screening Friday 9 November | 19:15 hours | Filmhuis Den Haag
Saturday 10 November | 16:30 hours | Filmhuis Den Haag
Original Title PARADIZE '89
Country Latvia/Germany
Section EXCITING, CURRENT CINEMA
In 2018, Latvia celebrates a hundred years since it has become an independent state. This compelling film is a part of the rich centenary program. The story is situated in 1989 and it's based on actual events during the fall of the Iron Curtain when Latvia was on its way towards restoration of democracy and independence. Screenings will be followed by Q&A with the director Madara Dišlere.
The year is 1989 and the TV news are reporting a state of emergency in Latvia. Girls who have been left with no adult supervision are preparing for war. Paula and Laura are city girls and they spend their summer holidays in a small town with their cousins, Maija and Linda. Left unattended, they enjoy freedom, imitate the life of adults, plunge into reckless adventures and get into trouble. When a state of emergency is announced on TV, Paula, full of hope, heads to the Baltic Way demonstration to join hands with two million people in a human chain spanning across the three Baltic states: Lithuania, Latvia and Estonia. The film is a part of the centenary program of the Ministry of Foreign Affairs of the Republic of Latvia.
Right now, in this rapidly changing world it feels important to tell a personal story. Yet it is one that unifies so many of us who experienced the fall of the Iron Curtain as children. I sincerely hope that my film will spark a much needed dialogue between kids and their parents about freedom in the very broad and the very intimate sense.


Nose: Ouhh this is a far livelier, more youthful Jura than we're used to. The peat certainly isn't pulling any punches, but is wrapped in tart, fruity aromas. Underneath the prominent barley profile await scents of grapes and forest fruits. Although Prophecy's nose is decidedly crisp, there's still that slightly musty Jura smell that I've come to appreciate over the years. Certainly lots happening on the nose, but I'm not yet convinced it's all good news. Can these aromas bind together into a great whisky?
Palate: It only takes one sip to answer that question with a resounding "yes". Prophecy is beautifully balanced, combining that boisterous spirit of a young peated whisky with a wealth of complexity. I suspect there are some sherry casks thrown into the mix, as flavours of raisins and hazelnut mingle with a subtle hint of nutmeg. The peat is never far off, accompanying briny notes of smoked kippers and seaweed.
Finish: The finish doesn't disappoint, and brings exactly what you'd expect of a heavily peated whisky. The aftertaste is pleasantly salty, showcasing Jura's maritime character.
Verdict: The 'profoundly peated' advertised on the box is no word of a lie. You shouldn't expect Ardbeggian levels of peat here, but compared to other Juras, Prophecy certainly packs a punch. I suspect this dram is quite a young Jura, but that youthfulness doesn't for one moment distract from the fact that Prophecy is an extremely engaging, complex whisky. With Jura completely overhauling its range in early 2018, you don't have to be a prophet to see that Prophecy will become a scarce commodity in the future. Be sure to snap one up while you still can, I for one will miss this whisky!
Jura at its most maritime, with the distillery as the perfect backdrop to Jura's seafront.
That's a good one. To be honest, I will be missing the old Jura range (with the Diurach's Own being the expression whose discontinuation saddens me the most). Still, I am open to try their new whiskies and I'm sure there's gonna be some real jewels among them, too.


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Held the ISB Summer Bass School at the University of Cincinnati from 1977-1981.
Supported the 1978 and 1982 Isle of Man International Competitions and Workshops in Great Britain.
Held the Zimmermann/Mingus Competition with classical and jazz divisions in Cincinnati in November, 1981.
Appointed Jeff Bradetich the Executive Director and Editor of the ISB in July, 1982.
Changed the format of membership publication from newsletter to magazine.
Held 1984, the ISB convention at Northwestern University, in Evanston, IL. Jeff Bradetich was Convention Chair.
Sponsored 1984 International Composition Contest.
Held 1986 ISB convention at the University of Texas at Austin, David Neubert was Convention Chair.
Check out these photos from the FIRST ISB Convention in 1984!!
Need a dose of humor?
The Bass Base of Amarillo; The penalty for students not practicing for Bass Base. Inez Patterson and victim Kevin Waggoner (Bass World, Vol. IX, Issue I, Fall '82, p. 32).
Hans Roelofsen and Rudolf Senn premiered Bottesini's Grand Duo Concertant's "original version" with the Concertgebouw in Amsterdam (Bass World, Vol. XI, Issue III, Spring '85, p. 29).
David Neubert, not David Murray, hosted the Austin '86 Convention. This photo (bowing over the left hand) was taken during a performance of Eugene Kurtz's "The Last Kontrabass in Las Vegas" with Barbara Hahn doing the narration. There will be more stories to tell at the Ithaca Convention during the Panel Discussion featuring many of the ISB Past-Presidents and Founder, Gary Karr.


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Groups and Organisations in T&T
The 2 Cents Movement is a youth-led non-profit organisation that uses performance art in youth outreach aimed at creating confident, socially conscious, responsible young citizens. We focus on engaging youth on critical issues relevant to their development using creative spaces for discourse and action. Our organisation strives to professionalize youth-centered, arts-based interventions and become the leading youth arts outreach company in the Caribbean.
https://2centsmovement.com/
https://www.facebook.com/The2CentsMovement/
868Change mission is to direct resources to uncommon solutions for a vibrant and healthy Trinidad and Tobago. We believe that our solutions will not come from the same thinking and approaches of yesterday, but from passionate citizens who are bold enough to address problems in new and daring ways. Broken systems need brave and unlikely heroes, our mission is to create an environment where these ordinary citizens can bloom.
https://www.facebook.com/868CHANGE/
Association of Female Executives of Trinidad and Tobago (AFETT)was formed in 2002 to bring together female executives, exposing them to networking opportunities, leadership training and business ideas.
http://www.afett.com/
https://www.facebook.com/groups/37617198282/
A.S.P.I.R.E T&T is a non-governmental, non-profit advocacy group lobbying for Sexual and Reproductive Health and Rights, particularly in the area of abortion since 2000.
https://www.facebook.com/ASPIRE-Trinidad-Tobago-133458550088316/
Break the Silence: End Chld Sexual Abuse is an action research project and awareness campaign on issues surrounding Child Sexual Abuse (CSA), incest and implications for HIV/AIDS that originated at the IGDS, The UWI since 2007.
http://sta.uwi.edu/igds/breakthesilence/index.asp
https://www.facebook.com/breakthesilenceendCSA/
Breast Feeding Association of T&T was founded in 1977 to support mothers, babies and their families in breastfeeding through effective counselling and education while assisting all sectors of the community to appreciate the benefits of human milk.
https://www.facebook.com/TIBS.tt/
Caribbean Association for Feminist Research and Action Trinidad and Tobago( CAFRA T&T) is a non-governmental, non-profit women's organization, whose mission is to celebrate and channel the collective power of women for individual and societal transformation, thus creating a climate in which social justice is realised.
https://www.facebook.com/CAFRATT/
Caribbean Forum for Liberation and Acceptance of Gendersand Sexualities (CariFLAGS) is a forum for sharing information, ideas, efforts and aspirations regarding our regional movement for policy and cultural change.
https://www.facebook.com/groups/cariflags/
https://groups.yahoo.com/neo/groups/cflag/info
Caribbean Institute for Women in Leadership (CIWIL)The Caribbean Institute for Women in Leadership (CIWIL) is a non-partisan and independent institution, established to monitor and strengthen the work of increasing women's political participation in the region.
https://www.facebook.com/Caribbean-Institute-for-Women-in-Leadership-104868243468/
Caribbean Male Action Network (CariMAN)
The Caribbean Male Action Network (CariMAN) is a regional network of individuals and organizations in Caribbean region working to challenge existing social and cultural beliefs and norms around masculinities and advocate for equality and justice for all.
http://menengage.org/regions/caribbean/
https://www.facebook.com/caribbeanmaleactionnetwork/
Caribbean Network for Integrated Rural Development (CNIRD) is an independent regional non governmental organization founded in 1988, whose focus is on networking with national and sub regional intermediaries based in the Caribbean region, with the objective of achieving integrated rural development.
http://cnirdregional.org/cnird/about-cnird/
https://www.facebook.com/CNIRD-Regional-211811152253357/
Cashew Gardens a Model Community
Cashew Garden's endeavors to provide the community with opportunities for growth and development. Our desire is to become 'A Model Community' that represents the cohesiveness of teamwork, love and country.
https://www.cashewamodelcommunity.org
https://www.facebook.com/CGModelCommunity/
CEDAW Committee of Trinidad and Tobago (Working Group)
The CEDAW Committee is made up of a diverse group of individuals representing organizations, communities, cultures, genres and perspectives with the common goal of Collaboration, Education, Development, Advocacy, Wisdom and oversight of the convention of which the state is a signatory.
https://www.facebook.com/TTCEDAWChamps/
Coalition Advocating for Inclusion of Sexual Orientation (CAISO) aims are: to foster a forward-thinking, visionary and humane approach to sexual orientation and gender identity; to secure full inclusion in all aspects of national life, social policy and citizenship regardless of sexuality and gender; to develop capacity, leadership and self-pride in our own communities, and to mobilise an advocacy movement for social justice in partnership with others.
http://gspottt.wordpress.com
https://www.facebook.com/caiso/
Trinidad and Tobago Coalition Against Domestic Violence T&T opposes the use of physical, emotional, psychological, sexual, financial and spiritual violence as a means of control over others.
https://www.facebook.com/TTCADV/
Conflict Women Financially empowering survivors of domestic and sexual violence by selling their beautiful handcrafted jewelry through our award-winning Butterfly Project.
http://www.conflictwomen.com/
https://www.facebook.com/conflictwomenltd/
Create.future.good is a social enterprise with a core purpose of promoting the awareness and advocacy of children's rights. We have created a platform for curious thought and visionary problem-solving through innovative projects and other creativity-based interventions.
https://www.facebook.com/createfuturegood/
The Cropper Foundation
The concept of the Foundation is to act as a framework mechanism for networking people, dialogue and resources across various sectors of the society for the public good and to influence, participate and contribute to Sustainable Development policy and practice – locally, for the Caribbean region, and globally.
http://thecropperfoundation.org/
https://www.facebook.com/TheCropperFoundation/
Families in Action promotes healthy family life, balancing emotional, physical, spiritual, social and psychological needs. We are moved to regenerate both the family unit and/or any individual of that unit experiencing pain, isolation, addiction or dysfunction
http://www.familiesinaction.net/
https://www.facebook.com/fia.familiesinaction/
Fondes Amandes Community Reforestation Project (FACRP) is a community based organization that fights dry-season fires around the Fondes Amandes watershed including planting of forest and fruit trees and gathering of seeds and natural materials for making craft. It has become one of the most successful eco-projects in the Caribbean and is widely recognised as a model for sustainable development in the region.
http://facrp1.webs.com/
https://www.facebook.com/facrp/
Heart of a Sister Family Foundation's mandate is to positively impact communities one family at a time. Soul Of a Brother remains the male-arm of our organization.
https://www.facebook.com/HeartOfASisterFoundation/
I Am ONE TnT is a Community-Based organisation in Trinidad and Tobago which seeks to address the needs of Gender and Sexual Minorities.
https://www.facebook.com/iamonetnt/
Network Of NGOs of Trinidad & Tobago For The Advancement Of Women is a national body advocating for change and fostering of participatory processes to help women build a better life for themselves.
https://www.facebook.com/Network-of-NGOs-of-Trinidad-and-Tobago-For-The-Advancement-of-Women-478979165460354/timeline
Network of Rural Women Producers, Trinidad and Tobago (NRWPTT) was formed in 1995 and is a national umbrella organization comprising a membership of over 60 small businesses and individuals. Their vision is to be a national umbrella body promoting rural women issues and empowering women to enhance their economic and social well- being.
http://nrwptt.net/about-us/
The National Union of Domestic Employees (N.U.D.E.)
https://www.facebook.com/The-National-Union-of-Domestic-Employees-NUDE-286297148076606/
Tribute to Clotil Walcott:
https://www.facebook.com/TributeToClotilWalcott/
Organization for Abused and Battered Individuals (O.A.B.I.) was founded in 2008 by Sherna Alexander Benjamin. The organization exists to address the needs of all women, girls, men and boys, within Trinidad and Tobago, the Caribbean and Latin America. While the organization work with every one, particular interest is placed on working with women and girls, persons who are at risk, have been victims of, or are victims of CSA, DV, SA, and GBV and persons who live in depressed and rural communities.
http://www.oabivoices.org/#!who-we-are/c1pf3
https://www.facebook.com/OabiOrganization/?fref=ts
PSI-Caribbean is one of 69 country programs within the global network of Population Services International (PSI). It is based in Port of Spain and working across twelve English-speaking islands of the Eastern Caribbean. PSI's World headquarters is in Washington, D.C. with a European office in Amsterdam. It is a global health organization dedicated to improving the health of people in the developing world by focusing on serious challenges like a lack of family planning, HIV and AIDS, barriers to maternal health, and the greatest threats to children under five, including malaria, diarrhoea, pneumonia and malnutrition. Their Got It? Get it campaign is a youth oriented, Caribbean-flavoured branded campaign that has the ultimate goal of empowering Caribbean youth to take responsibility for their sexual health.
http://psicaribbean.com/
https://www.facebook.com/GotitGetitSafeSex
Random Acts of Good Deeds (RAGD) champions youth leadership and encourages social responsibility. RAGD partners with other NGOs and social programmes that uplift and assist others physically and emotionally.
https://www.facebook.com/RandomActsOfGoodDeeds/
Rape Crisis Society of Trinidad and Tobago (RCS) was established to address the issues of sexual and domestic violence, particularly as they impact on the most vulnerable members of society, through counselling and public education and is a focal point for active work towards change in all areas affecting these issues.
http://www.ngocaribbean.org/index.php/rape-crisis-society-of-trinidad-tobago/
The Silver Lining Foundation
The Silver Lining Foundation is a youth led Non-Governmental Organization (NGO) acting to serve the interests of the youths of Trinidad & Tobago and the Caribbean region, as a whole. The organization primarily acts as a guardian body for marginalized youths seeking to prevent suicide and discrimination. The focus, while on bullying and discrimination, is centred on youth with regards to Lesbian, Gay, Bisexual and Transgender (LGBT) issues and those of Gender Identity & Expression.
https://silverliningtt.com/home/
https://www.facebook.com/SLFTT/
Single Mothers Association of Trinidad and Tobago
This is a safe space where "Single" Mothers can connect with one another, exchange ideas, challenges, tips and successes.
https://www.facebook.com/Single-Mothers-Association-of-Trinidad-and-Tobago-SMATT-766493116859831/
Trinidad and Tobago Association of Responsible Persons (TTARP) provides services for retired persons in T&T. It facilitates mature citizens (persons 50 years and older) to access benefita they may not have enjoyed before.
http://ttarp.org/
https://www.facebook.com/ttarp.responsiblepersons?fref=ts&ref=br_tf
Trinidad and Tobago Institute for Women in Leadership (TTIWIL), formerly the Network Training Centre was envisioned as a center of excellence for women's access to a potential source of relevant and useful information – for enhancing women's transformational leadership and ability to participate in decision-making, to defend their rights as well as for action to promote their social, political and economic advancement.
http://ttiwil.org/
https://www.facebook.com/ttiwil/
Trinidad Youth Council
Trinidad Youth Council an all-inclusive, non-partisan, non-governmental, non discriminatory, youth led, youth oriented, youth structured national youth movement aimed to synchronize youth development at the grassroots and wider community level. Its initiatives are derived directly from the people who make up its ranks.
http://www.trinidadyouthcouncil.com/
WOMANTRA is a Caribbean-based, Diasporic feminist group geared toward producing counter-narratives to mainstream discourses, around what is important, newsworthy or a feminist issue. We do this by posting material from woman-centered and feminist blogs and websites, paying attention to intersectionality - particularly race, individual stories and experiences, sharing scholastic and activist opportunities and supporting each other's scholarship and activism.
https://www.facebook.com/groups/womantra/
Women. Everywhere
Mission statement: "Share. Inspire. Empower" is a call to action: each one of us has a role to play in contributing towards the best possible quality of life for Women and girls today. By sharing our individual stories, we have the chance to inspire, to heal and above all, to open the doors to our collective Empowerment.
http://women-everywhere.com/
https://www.facebook.com/Womeneverywherett/
Women's Institute for Alternative Development (WINAD) is a women's organization committed to strengthening the capacity and social consciousness of women and girls to lead social transformation in Trinidad and Tobago. WINAD's programs enable women and girls to explore and embrace an alternative leadership framework which integrates the collective genius of all the people.
http://www.winad.org/
https://www.facebook.com/Womens-Institute-for-Alternative-Development-WINAD 412270812218785/timeline
Women Working for Social Progress(Working Women) (founded in 1985) mission is to create positive spaces for women, primarily, but also men and children, of all ethnicities and social groups in T&T to improve their own lives and to bring about positive change in their communities and their country. We will accomplish this through advocacy campaigns, education programmes and support systems, guided by our core values of equitable access to economic resources and decision-making, non-violence, and mutual support.
https://www.facebook.com/Women-Working-for-Social-Progress-102740919791413/
Young Men's Christian Association Tobago
https://www.facebook.com/ymca.tobago
Young Men's Christian Association(YMCA) of Trinidad and Tobago is a values based human development organisation operating in Trinidad & Tobago.
http://www.ymcatt.org/
https://www.facebook.com/YMCAofTrinidadandTobago/
Young Women's Christian Association (YWCA) of Trinidad and Tobago is a non-profit, non-denominational and non-governmental organization which has been providing service to the people of Trinidad and Tobago since 1943. We are committed to the empowerment of women, girls and youth and we are part of an international movement in 125 countries around the world.
https://www.facebook.com/YWCA-Trinidad-Tobago-175746965814742/
International Organizations in T&T
The UNAIDS Caribbean Sub-regional Office is responsible for the 16 Caribbean countries that are member states of the United Nations. All 16 countries have reported on the status of their HIV epidemic. The UNAIDS team offers the Caribbean the broad expertise of cosponsors and other UN organisations in areas such as program development and management, women and child health, education, legal networking, community care initiatives and resource mobilisation. The goal is an expanded response to HIV in the region with the world's second highest HIV prevalence.
http://unaidscaribbean.org/about-unaids
https://www.facebook.com/unaidscaribbean/
United Nations Association of Trinidad & Tobago (UNATT) is a voluntary non-profit organization established to advance the objectives of human development, the promotion and maintenance of peace and respect for human rights and is open to individuals who are 18 years and over.
http://www.unassociationtt.org/index.htm
United Nations Development Programme (UNDP) aims to create an enabling environment where the Government has the capacities for inclusive and sustainable human development; meet the national commitments. UNDP has been in Trinidad and Tobago for over fifty years, its office was established in 1961 and since then it has introduced several programmes to assist in development, and established many institutions to facilitate national growth. UNDP Trinidad and Tobago is also responsible for Aruba, Curacao and Sint Maarten.
http://www.tt.undp.org/content/trinidad_tobago/en/home.html
https://www.facebook.com/UNDP.Trinidad.and.Tobago
United Nations Volunteer (UNV) Programme in Trinidad and Tobago can take you on a journey to learn about the rewarding nature of volunteering in general and the remarkable achievements of the UNV Programme in T&T.
https://www.facebook.com/UNVTT/
Alternative lists
For comprehensive lists of NGOs in Trinidad and Tobago and the region go to:
The NGO Caribbean Development Foundation (NCDF) is a regional organization incorporated to make its contribution towards the development of NGOs in the Caribbean region, and campaigns for change on various human rights issues in the region. It was incorporated in Trinidad & Tobago in 2007, as such it is based in Trinidad.
http://www.ngocaribbean.org/
T&T NGO News and T&T NGOs on facebook
https://ttngonews.com/
https://ttngonews.com/trinidad-tobago-ngo-nonprofit-facebook/


XHTML (or HTML) and CSS for marking up and styling information. (XML is commonly used, although any format will work, including preformatted HTML, plain text, JSON and even EBML).
Like DHTML, LAMP, or SPA, Ajax is not a technology in itself, but a term that refers to the use of a group of technologies together. In fact, derivative/composite technologies based substantially upon Ajax, such as AFLAX, are already appearing.
Since XMLHttpRequest is now implemented across the majority of browser marketshare, the alternative techniques are now less popular, however they are still used where wide compatibility, small implementation, or cross-site access are required.
Ajax applications are mostly executed on the user's computer; they can perform a number of tasks without their performance being limited by the network. This permits the development of interactive applications, in particular reactive and rich graphic user interfaces.
Ajax applications target a well-documented platform, implemented by all major browsers on most existing platforms. While it is uncertain that this compatibility will resist the advent of the next generations of browsers (in particular, Firefox), at the moment, Ajax applications are effectively cross-platform.
While the Ajax platform is more restricted than the Java platform, current Ajax applications effectively fill part of the one-time niche of Java applets: extending the browser with portable, lightweight mini-applications.
One major complaint voiced against the use of Ajax in web applications is that it might easily break the expected behavior of the browser's back button (see Jakob Nielsen's 1999 Top-10 New Mistakes of Web Design). The different expectations between returning to a page which has been modified dynamically versus the return to a previous static page might be a subtle one. Users generally expect that clicking the back button in web applications will undo their last state change and in Ajax applications this might not be the case. Developers have implemented various solutions to this problem, most of which revolve around creating or using invisible IFRAMEs to invoke changes that populate the history used by a browser's back button. Google Maps, for example, performs searches in an invisible IFRAME and then pulls results back into an element on the visible web page; it is possible to track user behaviour via callbacks which are called whenever the back button is pressed, restoring the application state that existed at the time.
Network latency — or the interval between user request and server response — needs to be considered carefully during Ajax development. Without clear feedback to the user , smart preloading of data , and proper handling of the XMLHttpRequest object  users might experience delay in the interface of the web application, something which users might not expect or understand.  The use of visual feedback to alert the user of background activity and/or preloading of content and data are often suggested solutions to these latency issues.
There have been some critics of the term Ajax, claiming that Adaptive Path (the consulting firm that coined the term ) or other proponents are using it as a marketing vehicle for previously-used techniques    .
Using Ajax technologies in web applications provides many challenges for developers interested in adhering to WAI accessibility guidelines. Developers need to provide fallback options for users on other platforms or browsers, as most methods of Ajax implementation rely on features only present in desktop graphical browsers.
Web developers use Ajax in some instances to provide content only to specific portions of a web page, allowing data manipulation without incurring the cost of re-rendering the entire page in the web browser. Non-Ajax users would optimally continue to load and manipulate the whole page as a fallback, allowing the developers to preserve the experience of users in non-Ajax environments (including all relevant accessibility concerns) while giving those with capable browsers a much more responsive experience.
The major advantage of the declarative approach is that non-programmers are allowed to define user interfaces with HTML-like markup language. The disadvantage is that pages are becoming harder and more obscure to design and maintain, as they become more sophisticated.
Ajax gives software a fresh look Blurring the line between desktop and Web applications.


I have slowly been dealing with all the emotions that come from a failed IVF cycle. I keep going from being angry to being sad. Some moments I am fine and then all of a sudden the sadness hits. I am sure this time of year doesn't help. The holidays seem to revolve around children. This is the time of year that that void seems so much bigger. I have been asking myself why this is happening. Why do I feel like I am being punished? I am sick of the surgeries, injections, appointments, blood work, fears, physical and emotional pain and of course all the tears and heartache. I want my life back. I don't like to use hate but I hate that they have no reason why this isn't working for us. I hate that if we were a "normal" couple we would probably be trying for our a second child right now. But we're not. We still don't even have our first. At this point I would give my left arm just to have one child. I am sick of feeling sad. I am sick of feeling like I am out of place. I am just sick of feeling like this but most of all I am sick of not having what comes so naturally to others.
We got our tree early this year. We had a big hole in our living room where the fuse ball table used to be. We sold it because it was basically just a coat rack. Well we definitely learned something from going to pick out a tree early. It is not a good idea to go on their first day open. We pretty much have a Charlie Brown tree. All the trees were wrapped up when we got there because they had just opened. What we thought looked to be a nice big tree when they unwrapped it ended up being a not so full, drunk person trimmed it, crooked top looking tree. We tossed some garland, ornaments and lights on the thing and called it a day. It is a bit skimpy in the garland and light area. This will be the second Christmas that we have struggled with trying to have a child. To be honest, I just want this year to be over. This has been probably the worst year of my life. I am happy for that because it is almost over and it can only go up from here. 2013 will either bring us a pregnancy, baby or a soon to be adopted child. I can only go though so many more cycles. Hubby is 11 years older then me so we really don't have a lot of time. We are considering looking into adoption next year. I figure I will only have about 2-3 more IVFs in me before I give up and move on. The thing is with IVF it knocks you down and only when you are staggering back to your feet is when you are hit with another cycle and knocked back down. I am tired of this game. My life revolves around IVF. I want to be happy again and I want my heart not to feel so heavy. I know that having a positive attitude can make any situation better but sometimes we just have to give in and mourn. Tomorrow is my pre-op appointment with my Dr. Hopefully she will give us our next steps and let us know about the costs of PGD. I just hope we get some answers soon.


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by LS Murphy
Looking back to Spring Training, the 2010 St. Louis Cardinals had only one real question: third base. David Freese got the job. With his recent drunk driving arrest, most of Cardinals nation saw this as the only weak link in the lineup.
Boy, were we wrong.
Freese proved a solid defender and a nice bat. Then he got hurt. But that isn't the only thing that went wrong for this team. If it was, we probably would be heading into October ball.
1. Skip and Brendan - They got off to a bad start. In his second full season at second base, we can all agree that Skip is still learning the position. But at what cost? He's an incredibly gifted athlete and a professional. Despite criticism, he thrived last season. Unfortunately, he got off to a terrible start. In 2009, he had 9 errors. This year that number balloon to 16.
Brendan Ryan, who has the potential to win a Gold Glove, didn't fair much better. With the range to rival the great Wizard, Ryan went from 8 errors in 2009 to a whooping 17 in 2010. And he didn't look like he was having fun. Brendan likes to have fun. We've seen the videos of his jokes and childish antics. When he isn't having fun, he isn't playing like he can.
Skip and Brendan's early struggles should've been a sign. But the team kept us in contention anyway.
2. Brad Penny - Here is my biggest plea to John Mozeliak for the off-season. DON'T SIGN ANY PITCHERS THAT WILL END UP GETTING HURT! Okay, I know that there is no way that Mo could've foreseen Penny's injury but this is a theme with the St. Louis Cardinals. We offer a big contract and we get jack in return because the player gets hurt. Mark Mulder? Kyle Lohse? It's a theme.
3. Kyle Lohse - What a waste of money.
4. Chris Carpenter - Okay, Carp's one of the best but something was up with him this season. The normally cool, calm, and collected Carpenter lashed out. A LOT. Brendan Ryan got a major chewing out. So did Dusty Baker, but Baker deserved it. Carpenter's a leader in the clubhouse. If his anger was that apparent to the fans, what was he like in the clubhouse? Quite frankly, I believe that the lack of anger management took over him on the mound as well. We all know he's passionate but pissed? Something to think about.
5. Tony LaRussa - Now, a lot of fans hope he's gone. I'm not one of them. LaRussa's quirky. He's getting crappier as he gets older. He's moodier too. But he's still brilliant. That doesn't mean there isn't room for improvement here. Maybe it's time TLR realizes that he sometimes over-manages his club. It's becoming a bit of a joke when the lineup changes almost every game. And his public mini-feud with Colby Rasmus didn't help much. Then there is the hiring of Mark McGwire. Interviews showed that they have two different philosophies for hitters. Be aggressive (TLR) or be patient (Big Mac)? For a player, you're damned if you do or damned if you don't. That's not good. I'd love to see LaRussa back next year but he needs to learn from his own mistakes and get on the same page as his hitting coach.
6. Colby Rasmus - I've said it before and I'll say it again: If Colby wants to leave, trade him. Don't get me wrong, he's talented and has the potential to be a great center fielder. But he asked to be traded in 2009 and again in 2010. Let him go and get something in return. One unhappy player in the clubhouse is one too many.
The Cardinals have a lot of work to do in the off-season. Sign Albert. Find another starting pitcher, preferably one that doesn't cost more than seven million for nine games. Find some utility players that aren't named Randy Winn or Aaron Miles.
Yep, Mo has a lot of work to do. It should be an interesting off-season.
Follow LS Murphy on Twitter at http://twitter.com/LSMurphy
Or read her blog here: http://LSMurphy.com
Cardinals Mix blog featured writers LS Murphy,Brian F. Logush
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Preheat broiler. In a medium bowl whisk together eggs, salt, and crushed red pepper. Heat olive oil in a 10-inch oven-going skillet over medium-high heat. Layer zucchini slices on bottom of skillet in an even layer. Cook for 3 minutes, turning once. Top with cherry tomatoes. Pour egg mixture over vegetables in skillet. Top with mozzarella balls and walnuts. Cook over medium heat for 4 to 5 minutes or until sides begin to set, lifting with a spatula to allow the uncooked portion to run underneath.
Broil 4 inches from the heat for 2 to 3 minutes more or until set. Cut into wedges to serve.
Serving Suggestions: Serve with tomatoes slices and basil leaves and drizzle with additional olive oil.


Can Izanagi (set 26) be used by a ninja who's blocking and just wants to end the battle? So player A is sent out to attack and player B blocks and uses Izanagi to end the battle, can this be done or does a justu has to be on the chain in order to play Izanagi?
To answer ur question when the play A pass on playing a jutsu player B can now use a jutsu. If player B uses izanagi no one can play cards or activate effects while this card is on the chain so it will skip the battle phase.
Sorry about that, I tried but wasn't able to. So even if it reads "negate and discard 1 justu OR negate every other justu on the chain and end the current battle" I'm still able to play it even though there is no other justu on the chain cuorrect?