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Aging Fathers and Bipolar Children
June 13, 2010 /No Comments
More Harsh Reality: Aging Fathers and Bipolar Children
By Peter D. Kramer
Like depression, bipolar disorder has been romanticized as an affliction that confers hidden benefits. It may, but evidence is accumulating that suggests manic-depression results from the sorts of genetic disruption that contribute to other severe afflictions, such as schizophrenia and autism.
Readers of this blog may recall that schizophrenia and autism have been linked to "de novo" mutations [1], new abnormal genes that develop in the parent's sperm line and have not passed a Darwinian, evolutionary test [2] of fitness. The amino acid sequences are simply disrupted. Readers who have looked at yet earlier columns will recall that problems in gene regulation — epigenetic "scarring" [2] — can also give rise to mental illness. Scientists are now suggesting [3] that both of these mechanisms, new mutations and gene dysregulation, may be implicated in bipolar disorder.
Emma Frans and other researchers at the Karolinska Institute in Stockholm looked at a sample of over seven million Swedes and identified over 13,000 patients who had been hospitalized at least twice for bipolar disorder. The epidemiologists compared these subjects to over 70,000 matched controls. The investigators found that older fathers are more likely (the increase is on the order of 37%) to have offspring with manic depression. Older mothers had more bipolar children, too, but the association was less marked.
More, when the investigators looked at subjects with early-onset bipolarity, the association was very high. Compared with men in their early twenties, men over 55 were more than two-and-a-half times as likely to father a child who would go on be hospitalized for manic depression before age 20.
As with schizophrenia, some manic depression is familial and hereditary, caused in part by genes that have been passed down for generations. Conceivably, as well as doing harm, those genes may confer some adaptive fitness in sufferers or their relatives. Theorists have suggested that high energy and decisiveness, if not frank mania, may be the traits selected for over time. But the association between paternal age and mental illness points in a different direction.
Part of what distinguishes older fathers from older mothers is the nature of the gene line. Women's eggs go through 23 replications and then are held in the uterus (or expelled) throughout life; the eggs' genes may deteriorate, but they are much less vulnerable to "gene copy errors." In contrast, the cells that make sperm have gone through 200 divisions by age 20; by age 40, the number of divisions is up to 660. The sperm of older men is much more likely to have acquired mistakes through faulty replication. On a separate basis, altered genetic regulation in offspring has been related to paternal age. The Karolinska researchers speculate that these two mechanisms may explain why older fathers have more bipolar offspring. Either way, the influence is via "one-off" events, new abnormalities that changes the offsprings' brain development.
Other interpretations of the data are possible. Perhaps older fathers simply do a worse job of parenting. Here is where the question of early onset comes into play. Early-onset bipolar disorder is more heritable and less related to environmental factors. The fact that manic depression in the teenage years was so much more common in the children of older father speaks toward genetic transmission.
Interestingly, very young (teenaged) fathers also have more children who go on to experience early-onset bipolarity. It may be that "immature sperm" also give rise to de novo genetic disorders; or environment may play a role, via drug and alcohol abuse in the fathers, poor prenatal care on the part of young mothers, epigenetic problems in parents who themselves have been stressed, and then the additional disruption in the early lives of children born to parents who are poor and who (studies show) may demonstrate conduct disorders.
Of course, the association with paternal age proves nothing. It is easy to conjure up epigenetic evolutionary mechanisms that might explain the same data. Perhaps nature has arranged for the sperm of aging parents to be reconfigured to favor manic depression in a sort of "Boy Named Sue" strategy. If the parents may well die early, bipolarity could be a sort of double-or-nothing bet, in which low-level mania gives orphaned offspring a better shot at survival.
But the Karolinska researchers read the results differently. For now, bipolarity is another on a list of mental illnesses that seem to arise from random changes in genes or gene expression — which is to say: syndromes that have long been categorized as mental illness look like just that, expressions of frank biological pathology.
Published on Psychology Today (http://www.psychologytoday.com
The Way we Communicate with Young People by Text, Saves Lives!
Smartphone specially developed apps could be useful in managing depression.


text:
layout: page
title: Strong Eternal Research Conference
date: 2016-05-24
author: Beverly Salas
tags: weekly links, java
status: published
summary: Integer varius tristique dictum. Phasellus.
banner: images/banner/office-01.jpg
booking:
  startDate: 09/02/2016
  endDate: 09/03/2016
  ctyhocn: LEHPAHX
  groupCode: SERC
published: true
---
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redpajama_set_name: RedPajamaGithub


Ellie is desperate to find someone to look after their elderly housekeeper, Rose, whose health is failing. But employing a carer recommended by Ellie's difficult daughter, Diana, proves to be a mixed blessing as, when Ellie returns from a trip to America, she finds that Claire has implemented a number of bizarre changes to the Quicke household routine.
Claire, Ellie soon discovers, is heavily involved in 'The Vision', a local church with a charismatic, powerful pastor, who – seemingly coincidentally – is looking to Ellie's charitable trust for financial help in his current project of housing reformed addicts. Ellie is suspicious – and becomes more so, when details of Claire's chequered past comes to light. Can Ellie trust Claire or Pastor Ambrose? Ellie investigates and doesn't like what she finds.
The sixteenth in the Ellie Quicke series.
Publication date: End of June 2015.


Coinciding with the launch of Ian Russell's book "The Other End Of The Telescope" Heavy Chef is proud to present two action packed events (Cape Town 23rd May 2019 and Johannesburg 28th May 2019) that will cast an in-depth lens on the absurdities, the idiosyncrasies, the loneliness, the silliness and the downright backwardness of doing business in big business today. Ian and his team of co-contributors take a no-holds-barred look at corporate life and reveal why disruption is so rife today. This event is for entrepreneurs who want to disrupt the status quo, and for business leaders who don't want to be disrupted.
Speaker. Author. Advisor. Ian's career has involved almost every continent and spanned a quarter of a century. Drawing deeply on his priceless real world experiences as a CEO and senior leader, Ian ensures that you will never think the same way again.
Internationally renowned tech entrepreneur, computer scientist, speaker, digital thought leader and business leader. Honours include; Young Global Leader by World Economic Forum; FastCompany Maverick; Entrepreneur for the World by the World Entrepreneurship Forum; Forbes 30 under 30 - Africa's Best Young Entrepreneurs.
Valter is recognised globally as an expert in the fields of disruptive innovation, business re-imagination and emerging technologies. A member of the Singularity University and a recipient of the Constellation Transformation 150 award. A true digital thought leader.
CEO, businessman, brand and media exemplar; author, marking and communications commentator; spin doctor extraordinaire; Comrade Marathon medallist; bookworm. LEGEND.
The Other End of the Telescope is a high-speed gallop through the absurdities and challenges of getting things done in large companies, and the inherent contradictions in leadership and organisational behaviours that prevent businesses from realising their potential and achieving greater success. In this collection of thought-provoking essays, Ian Russell draws on more than 25 years' experience of leading and working in large organisations around the world to distil the key themes and challenges confronting big business today.


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Immaculate ranch on two parcels. 2.1 acres with the house and a 2 acre adjacent lot. Beautiful hardwood floors with area rugs. Newer kitchen, bath, windows, doors, appliances, furnace. Finished walkout basement. Large deck areas. Workshop area off garage. Large laundry area. Call Phil to see or show 607 372 3400.


In the South of England in Guildford, Surrey, you could order up a new MK2 Jaguar.
It could be modified with any number of menu items, whatever you would like, or could afford.
However, they didn't just bolt on handling bits and drop larger engines into lighter bodied cars.
Coombs incorporated race-proven engineering modifications that made the 3.8 litre MK2 not just considerably faster, but smoother, less stressed, and totally reliable.
Jaguar saloons led the field in production and touring car races during much of the 60s. Not surprisingly the quickest and most successful private entries came from John Coombs' himself from his Jaguar dealership in Guilford, Surrey.
One option at 185 pounds sterling (in the early 1960s), included 9:1 pistons, balanced crank, con rods, and clutch assembly. A lightened flywheel, gas-flowed head and trumpet carburetor intakes were also fitted. For an extra four pounds sterling the cylinder head would be machined to give 9.5:1 compression.
Some other menu items included, hand made exhaust with straight through pipes or performance 'silencers', Koni shocks, high ratio steering box, lowered ride height, long-range petrol tank....... (more details specifications to follow shortly).
John Coombs had significant race experience and his dealership simply got it right for a fortunate few racing enthusiasts, that included Graham Hill and Roy Salvadori.
A fully modified Coombs MKII easily reached 100 mph in company with the E-type, a full nine seconds ahead of the factory supplied version! It was the fastest and best handling saloon car available at that time !
So, what are these cars worth today? Unfortunately, no records appear to have survived at the dealership and only a few have been authenticated with proper documentation.
However, there are ways of telling an authentically modified Coombs from a modern reproduction and this site has helped owners to authenticate their cars.


Aloha - the warm weathers are nearly here! Celebrate in this graphic tee; it's super soft and comfortable for any daily adventure. Wear it under an unbuttoned shirt, or add extra layers to any lightweight sweater.


Marlene O'Brien has held leadership positions at each level of the League. She has served as a director of LWVUS, where she sat on the Advocacy, Membership and Development Committees, and also chaired the Bylaws Committee. As an LWVMA board member, Marlene has served as director; vice president; chair of Governance, Bylaws, and Nominating Committees; and member of the Board Operations Committee. She has also served as president of LWV of Wellesley and as the chair of that League's Bylaws and Nominating Committees. Marlene has also been a trustee of the League of Women Voters Education Fund.
Marlene is an attorney with private-sector experience in nonprofit, tax and corporate law. She has also practiced in the public sector, serving as senior assistant comptroller under New York City Comptroller Liz Holtzman and as deputy general counsel, children's services, under New York Mayor Rudy Giuliani.
Marlene holds a B.A. from Harvard-Radcliffe and a J.D. from Harvard Law School.


The Return of the Matriarch!
In the last 40 years society has undergone severe changes that have taken women out of the home and into the workplace. Ever since Rosie the Riveter made her way into the munitions and heavy equipment factories of this nation women have been making great contributions to corporate America. In the 60's we women were burning their bras and marching peace. In the 70's they were demanding liberation! All of this was considered progress to some degree, but at what cost? The nuclear family has suffered over the last 40 years. Being torn hither and yon and its tatters left to blow in the winds of change like a piece of litter with no direction.
Join Noreen this Thursday when she will host the Homestead Honey Hour and timely topic will be about the interesting and current trend of women leaving the corporate rat race and returning to a more simple life of homesteading and domesticity. An exciting turn away from corporate jobs and into the domestic arts.
Next: Next post: Be prepared knowing your nutrition information!


This is a big game so it does take a few more seconds to load than most other games. Use your UP ARROW key to accelerate. The LEFT & RIGHT ARROW keys can be used to steer the bike and press the DOWN ARROW key to brake.


What is the Movie Prometheus About?
Home > Entertainment > Movies > What is the Movie Prometheus About?
I've read that Ridley Scott has directed a new movie called Prometheus and I wanted to know what it's about. It'll be starred by Noomi Rapace and Michael Fassbender, who was in X-men First class, so I think the movie Prometheus is going to be great, but what is it about?
I think it has to do something with aliens but I don't know much about the plot, as the IMDB doesn't say too much about it. What is the movie Prometheus about, can you please let me know the plot?
So far there isn't much information available about the movie Prometheus, because it's new and the producers have decided to keep most of its details a secret.
But as always some information has been leaked, I can tell you that the movie Prometheus is about a group of explorers who discover a clue to the origins of mankind, which leads them on a journey to the darkest places of the universe. On this journey, they will fight a terrifying battle to save the future of the humankind. I think the plot is not very unpredictable but the cast looks great although it's just speculation since we don't know much about what the movie Prometheus is about.
Similar Threads for: What is the Movie Prometheus About?
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Clean and remodeled 3 bedroom 2 full bath river home directly on the bluff of Black River. New 100 foot riprap embankment with staircase and floating dock. Entire house repainted and new light fixtures. Masterbed and bath has new carpet, shower, vanity and stone tile. Kitchen has New Solid Surface Counter tops , Stainless steel appliances ,stone backsplash, refinished and painted cabinets. Living/Dining area has new laminate. Exterior: Outlet for generator -Field lines for septic tank and Painted Shed/vinyl lattice. All of this plus the view from the front porch of the river to top it all off. Priced to sell quickly.
© 2017 Liz Bianchini - Coldwell Banker Sea Coast Advantage Realty - (910) 799-3435.


They are pictured in the Marshall County Courthouse, which was one of several downtown locations open for guests to kick off the holiday season. The event is a project of the Holly Springs Main Street Chamber. Look for more photos from the Christmas Open House in upcoming editions of the newspaper.


text:
W-646 "Happy birthday Richie!!"
Mixed wrestling, 332 pictures 1920x1080 (FullHD), no nudity, no blood.
It is a huge day for 18 yr old Richie Barrett, beside being his birthday it is also the day he will start his pro-wrestling career. In the Western Wrestling League a wrestler must be at least 18 yrs old. So tonight is Richie's big night.
After a light dinner and some birthday cake Richie, his mother, father and his long time girlfriend head out for the arena. Both Richie and his girlfriend are very excited about tonight. Gina, his girlfriend is even more excited than Richie. She has been to almost all his training sessions and has come to love watching him wrestle. It seems As though Gina really loves three things, Richie, Richie wearing wrestling tights and Richie beating other wrestlers.
All during his training Richie was top of his class. He managed to defeat all the other wrestlers in the class. He came out of the training school as the top rookie in the league. On the drive to the arena Gina keeps asking Richie : What are you going to do to your opponent? Are you going to pin him or are you going to make him submit? Did you bring your new tights? I can't wait to see you in the ring Richie!!" As for Richie, he is trying to remain as calm as possible.
They arrive at the arena and head in. Richie kisses both his mother and Gina then shakes his father's hand and heads to the dressing room. Richie's parents and Gina head to their ring-side seats. In his dressing room Richie begins to get ready to wrestle. He quickly removes his street cloths and reaches into his new gear bag. He pulls out his jockstrap and slips it on, adjusting it and his manhood as he does. It is very safe to say the 18 yr old Richie Barrett is very well endowed. In fact he is quite large in that department.
He then pulls out his tights and wiggles into them. They are very light green in color and squeeze him like a second skin. He steps into his matching light green wrestling boots and laces them tight. He slips into a satin ring jacket. He is ready for the call to the ring.
He does not have to wait long before he heads to the ring and his very first match as a pro. As he steps between the curtains the light hit him. The crowd begins to cheer. They know of him in advance. Both his mother and father wrestle in this league and are very successful. Slowly he begins his walk down the aisle. As he proceeds the cheers begin. Also some very loud whistles and cat calls, these seem to be coming from the female fans. All of them seem to have noticed Rickie's very pronounced manhood.
As he enters the ring and goes to his corner, the whistles and cat calls get even louder. Suddenly the cheers change just a little. Richie's opponent has entered the arena. As his opponent gets close to the ring, Richie is stunned. Instead of a male opponent, the wrestler standing across the ring from him is a stunningly beautiful girl.
Richie looks confused by this and does not seem to know what to do. His father sitting at ringside runs to his son's corner. "There's been a last minute change Richie. You now have to wrestle her. She's only had two matches and is not much more experienced than you. You can take her. You're the best in your class. You can beat her son!!" Richie nods his understanding to that.
As he returns to his seat, Richie's mother ask : "Is he ok? Does he understand he has to wrestle her? Will he be alright?" his father nods, "he'll be fine. He knows he must wrestler her. He can beat her!!" A very surprised Gina asks "Does he have to wrestler her? She's a girl, how can she wrestle him?" Rickie's mother explains that she is also a girl and has wrestled many men and has defeated them. Also the Rickie has no choice.
The ring announcer begins:
"WRESTLING FANS!! This is a one fall to a finish contest. In the right corner she has a pro record of 2 wins and no loses at 20 years old please welcome Donna Tannery. And in the left corner making his pro debut he comes from a well known wrestling family at 18 years of age Richie Barrett"
Donna is dressed in a yellow thong cut leotard, black pantyhose and yellow boots. After the intros both wrestlers head to their corners and wait for the bell.
Back in his his corner, Richie looks into the crowd and gives the thumbs-up to Gina and his parents. He then quickly pulls up his tights and adjusts his manhood. A cross the ring Donna pulls up and smoothes out her pantyhose and adjusts her thong.
GONG!!! The bell begins the match. Both wrestlers exit their corners and begin to circle each other. Richie makes the first move and gets Donna in a HAMMER-LOCK. Using all his strength he bends Donna's arm up behind her back. Donna is instantly up on her toes. She grabs at her shoulder as her arm is bent. Richie's speed and aggressiveness has caught Donna off guard.
Regaining her composure, Donna looks for a way out of the hold. She twists back and forth trying to catch Richie off guard. She finally manages to get him looking one way as she goes the other. Grabbing his head with her free arm she tosses Richie over her shoulder and onto the mat.
Richie crashes the mat on his back. He is momentarily stunned and Donna takes advantage of that. Dropping down beside Richie, she grabs his arm, twists it as she pulls it between her legs. Donna has gotten Richie in a "ROUSEY ARM-BAR". He instantly begins to scream in pain "my arm, my arm!! Oh god you're breaking my arm!!" The 18 yr old wrestler is shocked by the pain from the arm bar. He twists from one side to the other and kicks his legs wildly. There is a look of both fear and pain on his face.
Kicking wildly Richie is able to eventually get close enough to the ropes to drape one of his boots over the bottom rope. As he does he instantly begins to scream at the ref. "Break the hold. Break the hold!!! I'm in the ropes, break the hold. Make her let me go ref!!! I'm in the ropes."
After what seems like an eternity to Richie the ref makes Donna break the hold and let Richie go. She steps back away from him as he struggles to get to his feet. Bent over at the waist, Richie holds his left arm in his hand. The fans at ringside can see the pain on his face as he stays against the ropes. After a few seconds the ref moves in and tells Richie: "come on Richie, get off the ropes and wrestle or I'm going to count you out!!"
Slowly he moves away from the ropes. Using surprise, Richie charges at Donna driving her across the ring into the corner on the other side. Donna's back slams into the turnbuckle, knocking the wind out of her. Richie takes full advantage, using his fore-arm he pounds the trapped girl over and over. He lands, head shots, he lands hard shots to her breasts and body. Donna is now in deep trouble. Richie has her trapped and is no hurry to let her go.
Out in the crowd Richie's mom, dad and his girlfriend are all screaming to him to get Donna. Richie's girlfriend Gina is very excited. She screams up to Richie, "Get her Richie, get her!!! Pound her, don't let her get away!! Knock her out Richie, knock her out." This is the first match she has ever seen and she is very excited by her boyfriend.
Back in the ring, Donna has slid down the turnbuckle and is slumped on the mat at Richie's feet. Not wanting to waist this opportunity, Richie pulls Donna to her feet. Twisting her arm he drags her to the the ropes. With her back against the ropes, Richie flings Donna across the ring. As she hits the ropes on the opposite side she is shot back toward Richie.
Waiting for her in the middle of the ring, Richie wraps his leg around hers, hooks her body around his and locks on an ABDOMINAL STRETCH. Donna's yellow leotard is stretched very tightly over her body and across her breasts. Almost instantly she begins to scream in pain. "AAAAAAUUU!!! OOOOOHH!!! IT HURTS, OH GOD IT HURTS!!!"
The ref moves in and asks Donna if she wants to submit. "NO-NO, I WON'T SUBMIT!! NOT GIVING UP!!" With her refusal to give up, Richie continues to apply pressure to the AB-STRETCH. Donna's face is a mask of pain. She knows she can't take much more of this hold. A she struggles against the stretch, she slowly inches her way toward the ropes. After several minutes Donna is at last able to grab the top rope. "ROPES, ROPES,I'M IN THE ROPES!! MAKE HIM BREAK THE HOLD. I'M IN THE ROPES!!!" As quickly as possible the ref forces Richie to let donna go.
For the next few minutes Donna wrestles defensively. She trades holds with Richie, with both wrestlers taking punishment. After several minutes a slow but noticeable change begins to take place. Richie has begun to slow down. Now is he that is in the holds longer. It's he that is having trouble escaping from her holds. It is he with the pained expression on his face.
In their front row seats, his family and Gina have noticed the change. Gina is particularly worried. "WHAT IS HAPPENING? IS HE IN TROUBLE? HOW IS SHE DOING THIS TO HIM?" Richie's parents try to explain to Gina. "YES GINA RICHIE'S IN TRIUBLE. HE'S GETTING TIRED. HEIS ALSO SLOWING DOWN. HE HAS TO DEFEAT HER QUICKLY NOW. HE HAS NO CHOICE"
Up in the ring is is easier said than done. In fact Donna is just about to take over the match. She has just easily escaped from an arm hold Richie had on her. Donna know knows that she must take over the match.
Grabbing Richie by his arm, donna twists it and whips him across the ring. As he flies back at her, she jams her arm between his legs and grabs his tights. She then hooks his head, lifts him off the mat and slams him down hard. Seconds after he crashes to the mat, Richie arches his back up, grabbing at his sides. It is very obvious to everyone that the slam was very painful.
Not waiting for Richie to get to his feet, Donna pulls him up. Again she jams her arm between his legs. Richie lets out a scream as she does. "AAAAAAAAAA!!" and tries to grab his manhood. Donna stops his as she again hooks his head. Up he goes as Donna lifts him off his feet and over her head. "SLAM!!!" Richie crashes to the mat. Again his back arches up.
Once more Donna pulls the now stunned Richie off the mat. This time she pushes him face first into the turnbuckle. She drapes his limp arms over the top rope and begins to pound on his back. Grabbing his arms and pulling them tight Donna traps Richie in the corner. As she holds his arms she begins to kick him in his lower back with her boot.
Richie begins to scream as the pain in his back increases. "MY BACK, MY BACK!! OH GOD MY BACK!! LET ME GO, LET ME GO!! I'M IN THE ROPES, LET ME GO!!!" As for her part Donna, even though she hears his screams keeps kicking Richie. "Ref, ref my back. OH GOD MY BACK !! MAKE HER LET ME GO!! SHE'S BREAKING MY BACK!!" The ref moves in and forces donna to release Richie.
As Donna moves back, Richie drops to his knees in the corner. His head and shoulders are slumped over the middle ropes as he rubs his back. The ref quickly moves in and tells Richie he must get off the ropes and to his feet. "COME ON RICHIE, YOU'VE GOT TO GET UP!! GET UP AND WRESTLE OR I WILL COUNT YOU OUT!!"
In their seats Gina and Richie's mom are trying to hold back their tears. Gina turns to his mom and asks "HE'S GETTING BEAT ISEN'T HE?HE'S GOING TO LOSE THE MATCH?" All Richie's mom can do is nod her head. His father leans close to Gina "HE HAS VERY LITTLE CHANCE TO WIN GINA!! YES, I THINK THAT RICHIE IS GOING TO LOSE THE MATCH!!"
20 yr old Donna, Richie's opponent has come to the same conclusion. As Richie struggles to get to his feet, Donna watches him closely. As he stands up she is on his instantly. Richie is dazed and confused. As Donna attacks him. He hold his arm across his face in fear as she moves in. He cries out as she does, "NO-NO, I'M NOT READY YET!! Don't please don't, I'm NOT READY, I'M NOT READY!!!!"
There are no time outs in wrestling. Donna grabs Richie and pulls him out of the corner. Back in the middle of the ring Donna goes between his legs and grabs his tights. She hooks his head and lifts him off the mast. Instead of a power slam, Donna slams Richie down across her thigh. He screams as his smashes into to her outstretched leg.
"MY BACK, OH GOD MY BACK. YOU'VE BROKEN MY BACK!!! "The look of complete terror on Richie's face is scary. Some in the crowd actually think the his back may be broken. Aside from the look of fear on his face, Richie has also started to cry. With tears in his eyes and that look on his face, Richie looks up at Donna. "I'M DONE DONNA. I CAN'T GO ON!! YOU'RE JUST TOO GOOD FOR ME!! JUST PIN. PLEASE JUST PIN ME!! I'M DONE!!"
Richie soon learns that is not how it works in pro-wrestling. Donna once again pulls 18 yr old Richie to his feet. She drives her knee into his mod-section causing him to double over at the waist. Taking his head she pulls it between her legs, she now has a STANDING HEAD LOCK on the teenage male wrestler.
Richie squirms, twisting and wiggling as he tries to escape the hold. Quickly Donna wraps her arms around his waist. With a powerful pull she lifts Richie off the mat and onto her shoulder. Donna now has him locked into an OVER THE SHOULDER BACK BREAKER.
In their front row seats both Gina and Richie's mother are openly crying as he is trapped in a painful submission hold. "She's going to beat him isn't she?" Gina asks, Richie's mom. "YES, GINA. RICHIE IS GOING TO LOSE THE MATCH. DONNA IS GOING TO SUBMIT HIM. HE IS GOING TO BE DEFEATED BY HER!!!"
Dangling painfully across Donna's shoulder tears of pain and humiliation run down Richie's cheeks. Inside his tights and jockstrap his manhood has swollen into a huge DEFEAT BONER. The end is only seconds away for teenaged Richie Barrett.
"NO-NO, OH GOD NO. She's going to beat me. I can't get out of this. She's got me!! Oh god no, she's got me-she's got me!!! Hearing this Donna ask the ref to see if Richie wants to submit to her. ASK HIM REF!! GO ON AND ASK HIM, DOES HE SUBMIT? IS HE FINISHED? DOES HE WANT TO GIVE UP YET?" The ref moves close to Richie, "What DO YOU SAY SON? YOU HAD ENOUGH YET? SHE'S GOT YOU, YOU KNOW SHE'S GOT YOU!! LET ME END IT, COME ON RICHIE GIVE IT UP, YOU'RE FINISHED SON. TIME TO CALL IT AND GIVE UP!!"
The terrified 18 yr old male wrestler knows it's over for him. He knows he is going to lose his very first match. He knows the Donna is going to submit him, for the rest of his career he will never be un-defeated. None of that matters now. Right now he is scared, in pain and exhausted. All he wants is to get out of this hold and out of the ring. He has been completely humiliated in front of his girlfriend.
"YES-YES!! I'M DONE REF!! PLEASE, PLEASE GET ME OUT OF THIS!!! OH GOD MAKE HER STOP!! SHE WINS, SHE'S BEATEN ME!! I GIVE UP!! I GIVE UP!! PLEASE LET ME GO!! I'M BEGGING YOU!! PLEASE LET ME GO!! OH GOD, I SUBMIT!! I SUBMIT, I SUBMIT!!!!"
For both Richie and Donna the match is over. Two young wrestlers with different outcomes. One a three time winner now and the other a loser in his first match.
Donna drops Richie to the mat and he falls at her feet face up. He is completely beaten. Unable to get to his feet, he lies there gasping for breath. His mouth open and tears running down his cheeks. The 18 yr old boy, thoroughly beaten by his female opponent. Three people are standing at ring side looking at the defeated teenager. Both Richie's mom and dad are completely shaken by his stunning defeat. Gina, his long time girlfriend is almost hysterical having seen her boyfriend destroyed by a female wrestler.
As for Donna, she is ecstatic over her victory. She stands over Richie with her arms in the air as the fans cheer wildly. She then puts her hands on her hips and looks down at her defeated male opponent. She walks to were Richie's parents and Gina are standing by the ring and softy says, "I'm so sorry I had to beat him. I hope he will be OK!!" Neither his parents or Gina know it he will ever be OK.
Slowly Richie gets to his feet. He grabs his back and tries to stretch it out by bending backward. He slowly makes his way to the ropes and his loved ones. "I'm sorry, mom and dad. I'm sorry I've been defeated. She was just too tuff for me." He moves in front of Gina. He still has his stiff DEFEAT BONER. "Oh god Gina, I let you down. I'm so sorry. You can never be seen !with me again. I've been beaten by a girl. You can't love me anymore!!
A very sad Gina quickly notices his huge defeat boner. "What's that Richie, were you turned by her. Did you find her sexy?" Richie is now completely embarrassed. "No Gina, I didn't find her sexy. This is a DEFEAT BONER. It's what happens to male wrestlers when they are defeated. She defeated me Gina. I was beaten by her. That's what this is Gina it's a stiff DEFEAT BONER!!"
A very sad Gina tells her boyfriend "Oh god Richie. I didn't know. I'm so sorry. I love you even if you did get beat by her. Please forgive me, I love I love you!!!" For the first time in almost 40 minutes Richie smiles.

redpajama_set_name: RedPajamaCommonCrawl


Availability: In universe, no additional deps.
Quality assurance: Package has test suite which is executed during the package build process.
Maintenance: generally well maintained in Debian (although we need a newer version in Ubuntu - already uploaded).
Looks fine to me. Would be nice to see a bug subscriber.
ubuntu-server team subscribed to bug mail.


Today we are going to share, "how you can delete temporary unwanted files" in Windows Manually by RUN or Disk Cleanup application. The method the delete Temp files from the computer / laptop is same for Windows 7 , Win 10, 8.1 , XP and Vista. Temporary files are those files which each program on your computer stores to keep the record of app data, cache and cookies.
Why should you Delete Temporary files from your computer ? Well the benefits of deleting the Temporary files are many, which includes: getting more free space on your PC SSD / HDD ( C Hard drive space fully occupied), optimizing the computer for better speeds.
You will get options to remove System error memory dump files, Temporary files, thumbnails, System queued Windows Error reporting and solution checking, Recycle bin and Temporary internet Files (Internet Explorer).
Temporary files are stored in C:\Users\Your PC Name\AppData\Local\Temp , in Temp folder all the temporary files are stored. Before trying this Solution make sure your programs and you don't need this files anymore. Some programs store this files as cache, so they do need files stored in TEMP folder. This is the shortcut way to delete the files from the Windows.
Now Delete the Temporary Files you don't need any more.
Both the solutions should work fine on almost any Windows Operations System (Windows 7, 8, 8.1, Win 10, XP / Vista).
You can also use some tool like Krojam Cleaner. It is one great tools that cleans your system of all the junk files.


text:
package main

import (
	"net/http"
	"runtime"
	"time"
)

var pipeline Pipeline

func reqFilterPipeline(id int) {
	defer wg.Done()

	dummyBlock := NewPipeline("dummy", dummyFilter)
	normalizeBlock := NewPipeline("normalize", normalizeURL)
	urlseenBlock := NewPipeline("urlseen", urlSeen)

	pipeline = connectPipeline(dummyBlock, normalizeBlock)
	pipeline = connectPipeline(pipeline, urlseenBlock)

loop:
	for {
		select {
		case <-exiting:
			debug("ReqFilter Pipeline exiting")
			break loop
		case req := <-reqFilterInputQ:
			ping()
			pipeline.Write() <- req
		case req := <-pipeline.Read():
			ping()
			if req != nil {
				if runtime.NumGoroutine() < 50000 {
					scheduleRequest(req)
				}
			}
		}
	}
	return
}

func scheduleRequest(req *http.Request) {
	lastTime := originTime[req.URL.Host]
	if lastTime == 0 {
		lastTime = time.Now().Unix() - reqCooldown
	}
	now := time.Now()
	secs := now.Unix()

	delay := reqCooldown - (secs - lastTime)
	wg.Add(1)
	go func() {
		defer wg.Done()
	loop:
		for {
			select {
			case <-time.After(time.Duration(delay) * time.Second):
				select {
				case reqFilterOutputQ <- req:
					ping()
					break loop
				default:
					debug("req lost by scheduled goroutine")
					break loop
				}
			case <-exiting:
				//debug("cancelling request at", strconv.Itoa(int((reqCooldown - (secs - lastTime)))))
				break loop
			}

		}
	}()
	originTime[req.URL.Host] = lastTime + reqCooldown
}


Abstract: The collapse of a pyrite-mining, tailing dam on 1998 contaminated an area of 4286 ha along the Agrio and Guadiamar river valleys in southern Spain. Over 2700 ha of the Doñana marshes, an important wintering area for wetland European birds, were contaminated. This study reports analyses of the tubers of Scirpus maritimus (an important food for greylag geese, Anser anser) collected in 2000 in the ''Entremuros'' (spill-affected area) and in nearby unaffected Don˜ana marshes (control areas). In the spill-affected area mean tuber tissue concentrations of Cd (0.25 mg kg-1) and Zn (61 mg kg-1) were greater than in those tubers from the control area (0.02 mg kg-1 for Cd, and 22 mg kg-1 for Zn); values of Cd and Zn in ''Entremuros'' (samples collected two years after the mine spill) were much smaller than those reported only a few months after the accident. Trace elements (As, Fe, Mn and Tl, and to a lesser extent Cd and Pb) showed a preferential accumulation in the outer skin of tubers. Surprisingly, concentrations of As and Fe were greater in tubers from some marsh sites not affected by the mine-spill than in tubers from the ''Entremuros''. We suggest that relic river channels within the Doñana marshes may be contaminated by trace elements from historic mining activities. An exhaustive study of macrophytes and other plant species in this area is recommended to identify potential risks to wildlife.
Description: 7 pages, 2 figures, 3 tables, 28 references.


text:
Postomino [] () ist ein Dorf in der Woiwodschaft Westpommern in Polen. Das Dorf ist der Verwaltungssitz der Gmina Postomino (Gmina Pustamin) und gehört mit dieser zum Powiat Sławieński (Schlawer Kreis).

Geographische Lage
Das Dorf liegt in Hinterpommern, etwa 15 Kilometer nördlich von Sławno (Schlawe) an der Wojewodschaftsstraße 203.

Geschichte

Die ehemals Pustamyn bzw. Wendisch-Pustamin genannte Ortschaft ist ein altes Guts- und Bauerndorf. Es ist wendischen Ursprungs, worauf auch die Endung 'min' des Ortsnamens hinweist. Seine erste urkundliche Erwähnung findet sich im Jahr 1301. Bald darauf wird der Ort Besitz der Familie von Below – bis zum Jahr 1792. Danach gehört der Ort wechselnden Besitzern, bis dann 1908 wieder der Name von Below auftaucht.

Pustamin lag von 1818 bis 1945 im Landkreis Schlawe i. Pom. direkt an der Grenze zum Landkreis Stolp am Schnittpunkt der Straßen Rügenwalde (heute polnisch: Darłowo) – Stolp (Słupsk) und Stolpmünde (Ustka) – Schlawe (Sławno). Der Ort war Bahnstation an der Bahnstrecke Schlawe–Stolpmünde. Bis 1945 bildete Pustamin einen eigenen Amts- und Standesamtsbezirk.

Bald nach der Besetzung durch die Rote Armee im März 1945 wurde Hinterpommern unter polnische Verwaltung gestellt. Die Bevölkerung von Pustamin wurde vertrieben.

Der Ort ist heute Ortsteil und Verwaltungssitz der Gmina Postomino.

Demographie

Ortsgliederung bis 1945
Vor 1945 bestanden in der die Gemeinde Pustamin sieben Wohnplätze:
 Dudel, Bauerngehöft, 1 km südlich von Pennekow
 Grünhof (polnisch: Wykroty), Gutsvorwerk, 2 km östlich von Pustamin, dicht an der Grenze zu Landkreis Stolp, ursprünglich einer der zwei Pustaminer Rittersitze bis 1784
 Hasenkrug, Bauerngehöft, 2 km östlich des Dorfes, wahrscheinlich ehemaliger Gasthof mit Ausspannung an der Straße Rügenwalde–Stolp
 Niederwald (Kłośnik), Gutsvorwerk an der Straße Pustamin–Thyn, 2,5 km südlich des Dorfes, angelegt in der Mitte des 19. Jahrhunderts
 Noras, Bauerngehöft, 1 km nördlich von Pustamin am Weg nach Schlackow am Hang zum Marsower See, hier stand früher die Pustaminer Erbpachtmühle
 Pustaminer Mühle, Windmühle am Nordende des Dorfes, auf dem Mühlenberg 55 m über NN., heute nicht mehr existent
 Rabenkrug, Gehöftgruppe südlich des Dudel.

Kirche

Evangelische Kirche
Bis 1945 gehörte die Kirchengemeinde Pustamin – mit der Kapellengemeinde Pennekow, ab 1928 auch Mitverwaltung der Kirchengemeinde Marsow – zum Kirchenkreis Rügenwalde der Kirchenprovinz Pommern in der evangelischen Kirche der Altpreußischen Union. Noch bis 1914 war sie dem Kirchenkreis Stolp-Stadt zugeordnet. Das Kirchenpatronat übten die Gutsbesitzer in Pustamin und des Gutes Seehof bei Pennekow aus.

Im Jahr 1817 wurde Pennekow in den Zuständigkeitsbereich der Kirchengemeinde Mützenow verlegt. Dort kam es allerdings wegen des Auftretens des rationalistischen Pfarrers Tischmeyer zum Konflikt, auf dessen gegnerischer Seite der Pennekower Kirchenpatron Heinrich von Below stand. An seiner Person entzündete sich eine neupietistische Erweckungsbewegung ("Belowsche Bewegung"). Erst 1863 wurden Pustamin und Pennekow wieder vereint.

Im Jahr 1940 zählte die Kirchengemeinde Pustamin 1525 Gemeindeglieder, von denen 800 in Pennekow lebten (zuzüglich 1000 Gemeindeglieder in Marsow). Die Kirchenbücher sind seit 1945 verschollen, nachdem auch schon ein großer Teil im Jahr 1879 beim Brand des Pfarrhauses vernichtet worden ist.

Heute gehört Postomino zur Parochie Słupsk (Stolp) der Evangelisch-Augsburgischen Kirche in Polen.

Römisch-katholische Kirche
Durch den Bevölkerungsaustausch nach 1945 ist die Konfessionszugehörigkeit der seitdem in dem Ort lebenden polnischen Bevölkerung überwiegend römisch-katholisch. Pfarrort war zunächst Słupsk (Stolp). Seit 1973 besteht die Pfarrei St. Florian in Postomino. Sie gehört zum Dekanat Ustka (Stolpmünde) im Bistum Köslin-Kolberg der Katholischen Kirche in Polen. Zur Pfarrei gehören die beiden Filialkirchen Marszewo (Marsow) und Pieńkowo (Pennekow).

Pfarrkirche
Das Gründungsdatum der Kirche liegt im Dunkeln. 1783 wurde sie nach einer gründlichen Restauration neu eingeweiht. Bis heute weist sie wertvolle Schnitzarbeiten an Altar und Taufstein auf. Als St.-Florian-Kirche ist sie jetzt Gotteshaus der polnischen römisch-katholischen Kirche. Nach 1945 wurde das evangelische Gotteshaus an die katholische Kirche enteignet, die es 1946 neu weihte und ihm den Namen St. Florian gab.

Schule
Über eine Schule in Pustamin gibt es die erste Nachricht im Jahr 1751. Um 1850 war die Schule zu klein, und es musste im Blick auf die steigenden Schülerzahlen eine zweite Klasse eingerichtet werden.

Das bis 1945 als Schulhaus benutzte Gebäude stammte aus den Jahren 1861/62. Es lag gegenüber dem Gutsinspektorenhaus und hatte Einliegerwohnungen für zwei Lehrerfamilien. Letzter deutscher Lehrer war Ernst Griep.

Persönlichkeiten

Söhne und Töchter des Ortes
 Bruno Groth (1926–2018), deutscher Keramiker und Maler

Mit dem Ort verbunden
 Theodor Gustav Harder (1762–1811), evangelischer Pfarrer in Pustamin
 Karl Thom (1900–1935), evangelischer Pfarrer in Pustamin

Siehe auch
 Liste der Orte in der Provinz Pommern

Literatur
 Der Kreis Schlawe. Ein pommersches Heimatbuch, hg. von Manfred Vollack, 1. Band: Der Kreis als Ganzes, Husum 1986, ISBN 3-88042-239-7; 2. Band: Die Städte und Landgemeinden, Husum 1997², ISBN 3-88042-337-7.

Weblinks
 Pustamin bei Meyers Gazetteer (1912, mit historischer Landkarte)
 Pustamin beim Heimatkreis Schlawe

Fußnoten

Ort in Pommern
Ort der Woiwodschaft Westpommern
Gmina Postomino

redpajama_set_name: RedPajamaWikipedia


text:
Q: Changing application name and packages I decided to change the name of my app.  I updated all references to the app including references in the Manifest, the project, the package names, etc.
If I grep the application's directory, all references to the old name are gone.
However, when I compile my application and send it to the emulator, the bottom right corner of Eclipse reads, "Launching OldAppName."
How do I fix this?  Obviously, there is a reference lingering around somewhere.

A: You need to edit Run/Debug entry name in project settings

redpajama_set_name: RedPajamaStackExchange


Can oral iron supplements or pentoxifylline improve outcomes in heart failure?
People with heart failure frequently have low iron levels, which can worsen their symptoms, make exercising difficult and even decrease their life expectancy. This iron deficiency could result because people with heart failure cannot absorb iron from the food they eat as their gut becomes inflamed. But we don't know if modifying gut inflammation using drugs will improve iron absorption in heart failure patients.
Clinical trials have found that intravenous iron replacement can improve exercise ability in people with heart failure, but we don't know how if cheaper oral iron supplements have the same effect.
Cardiologist Dr Darlington Okonko from King's College London has been awarded an Intermediate BHF Clinical Research Training Fellowship to work under the guidance of BHF Professor Ajay Shah. In his fellowship, Dr Okonko will carry out a number of clinical studies in people with heart failure. His studies will find out whether oral iron is as good as intravenous iron in correcting iron deficiency and improving a person's ability to exercise. He will find out whether gut iron absorption can be improved by the anti-inflammatory drug, pentoxifylline. He will also work out how correcting iron deficiency improves exercise capacity in heart failure.
This research could reveal a way to treat symptoms in people with heart failure that could make a huge difference to their quality of life.


text:
Minority Report Futurama
One of the intriguing things about Minority Report is that it represents at least three different story telling motifs, each of which could be lifted out and placed in some other context that would work just as well. On the one hand, it replays the familiar theme of a murder in which the innocent protagonist gets framed and spends the rest of the movie trying to prove his innocence while being chased by the authorities. The bad guys turn out to be part of the system that's meant to protect the little guy. Does that sound just like Harrison Ford in The Fugitive? Now let's add a twist and say that the murder hasn't happened yet, but it has been predicted to happen. In fact, the "system" in this case involves a society, even a police force, that relies on such predictions to prevent murders before they happen. They use clairvoyants, referred to as precogs, whose gifts have been enhanced by technology. Although the framing motif still remains intact, now the methods by which someone can be framed for a future murder become a lot more interesting and different. Note, however, that although this sounds like science fiction, the central mechanism, a pre-supposed belief in clairvoyance, is a paranormal phenomenon, not science. Also, the concepts of free will and determinism that it plays with are more philosophy than science as well.
So if the plot is pure action and drama and the twist turns it into a psychological thriller, where is the science fiction? Basically, it is in the setting in which the story takes place, which is simply human society in the relatively near future (2054 A.D). But unlike most other futuristic tales, this one attempts to be believable, and that alone is what makes this film stand apart from the others. Since the story line, which took some ideas from a short story by the always intriguing Philip K. Dick, relies only remotely on the setting in which it takes place, the creators did not have to mold the future to serve the plot. In fact, Spielberg conducted brainstorming sessions with scientists in various fields to get their predictions about what society might look like 50 years in the future. That's the kind of stuff sci-fi is all about and I'd rather spend a little time looking at what they came up with than doing just a run-of-the-mill movie review. After all, there's lots of that already on the web.
One of the first things you see is Tom Cruz in front of a huge transparent screen sliding images and data around and commanding various operations by making particular gestures with special laser gloves. This is a very natural extension of today's computer technology of course, and it showcased in 2002 a multi-touch type of interface at a time when Windows Surface was just an idea in a few people's heads. Surface was finally unveiled in 2007, and there's great demo video here on youtube. Microsoft's "surface" detects commands via camera image from below, which is actually more like the action-at-a-distance featured in the film than a touch screen device like the Apple iPad. Anyway, the opening sequence of the film that features this future technology plays like a digital symphony with Cruz as the conductor. In fact, the accompanying music track is a symphony that is cleverly worked into the action on screen - check it out here.
Another thing that struck me as quite insightful was the portrayal of the continuity of brand names. Many companies come and go but the ones that last tend to last a long time, and their images will change with the times. For example, car companies are so integral to society that they tend to hang around even when they almost go bankrupt. In the film we see a whole new transportation infrastructure but the same car companies building and selling the cars, often with the same or similar logos. Communications companies like AT&T have lasted forever also because of their importance to a working society. If you look at the number of companies today that were around 100 years ago, it is not hard to imagine them and others like them still being around 50 years from now. You would think this would be rather obvious and yet I've never seen it portrayed like in MR. And it's a win-win because the companies can look real cool and futuristic while Spielberg gets to collect the royalties.
The same goes for architecture. Many homes look the same as today because people like living in houses that look old and traditional and will keep them basically unchanged for many decades, even as more modern offerings are built. The creators really looked back in history to determine not only what might change, but also what might stay the same. That is just plain genius.
One thing that MR does not hold back on is the idea that human nature does not change even as technology advances. Cruz's character is shown going through a divorce and becoming addicted to some type of drug. The delivery mechanism is different and the physical side effects of the drug itself has been refined away, but the effect on a person's life is just the same. Crime will not disappear and so neither would the police, even if their methods change. Instead of fingerprint identification they use iris imaging in MR. If you can be identified instantly by your iris signature, the existence of a black market in eye transplants does not seem like a stretch to me.
Another thing that I think MR got spot on with is the steady encroachment of commercial advertising into our daily lives. We've seen this with every new technology that has come along. Telephones and telemarketers, radio and TV commercials, and now email spam and internet pop up ads. It makes sense in the context of free capitalism. If there's a way to use technology to make a buck, companies will do it. They will avoid public outcry by introducing it slowly so consumers can become acclimated. One of the more memorable moments was when Cruz walks into a mall and is greeted by personalized computer sales pitches based on a remote iris scan that is done as soon as he walks in. It really hits you just how real that might become someday, even if they use a simpler method to identify you.
There are just so many thought provoking ideas to throw around in this film. One of them that struck me as a little ahead of its time was the maglev transportation system. It will take some time to move from oil based infrastructure to electric battery while still keeping the current road system. But to build a whole new magnetic road infrastructure in the major cities and mass transit based on a free running car technology to match it seems closer to a 100 year development to me at least. I'm not even counting the extension of the road system to allow it to go straight up the sides of the buildings and into your apartment on the 47th floor. We're talking major integrated city planning. The helicopters used by the police don't require an infrastructure like that, but whether rocket powered vehicles like that could appear in 50 years is still up for debate. And of course, the little spider bots that search out people is way far off, even if easy to do on film with CGI.
I think the hardest idea to swallow was the way they portrayed the precogs. Even if you could find three people with such abilities, and even if they were willing to dedicate their entire lives to police work, could they really withstand floating motionless in a half dream state for their entire existence? That's just crazy, and even raises some ethical concerns. However, I do think that Jessica Capshaw did an excellent job portraying precog Evanna when she actually had to wake up and do something. I just discovered that Capshaw is Spielberg's stepdaughter, interestingly enough. But I will close here by saying that Minority Report remains a bit of an enigma. How can a film that contains so much fascinating insight suffer from such a one-dimensional plot line? Then again, it is a Spielberg film.
Tron Legacy Review