text:
using namespace boost::posix_time;

//! constructor
//! @param HMPn:	name of the motion primitive
Interval::Interval(string HMPn)
{
	//DEBUG: cout<<endl <<"Creating Interval object" <<endl;
	HMPname = HMPn;
	open = false;
	start[0] = -1;
	start[1] = -1;
	end[0] = -1;
	end[1] = pINF;
	possibility = 0;
	refPossibility = 0;
	risingTime = 0;
}

//! set the starting sample
//! @param sample:	starting sample
//! @return:		---
void Interval::setStart(int sample)
{
	start[0] = sample;
	start[1] = sample;
}

//! set the ending sample
//! @param sample:	ending sample
//! @return:		---
void Interval::setEnd(int sample)
{
	end[0] = sample;
	end[1] = sample;
}

//! start a new interval
//! @param &this_pos:	possibility of the monitored model for the current sample
//! @param &nSamples:	index of the current sample
//! @param &past_pos:	possibility of the monitored model for the previous sample
//! @return:			---
void Interval::startInterval(float &this_pos, int &nSamples, float &past_pos)
{
	open = true;
	start[0] = nSamples;
	start[1] = nSamples;
	end[0] = 0;
	end[1] = pINF;
	possibility = this_pos;
	refPossibility = past_pos;
	risingTime = 1;
}

//! print the interval status
//! @param:		---
//! @return:	---
void Interval::printStatus()
{
	cout<<"HMPname = " <<HMPname <<endl;
	cout<<"status = " <<open <<endl;
	cout<<"starting sample = [" <<start[0] <<";" <<start[1] <<"]" <<endl;
	cout<<"ending sample = [" <<end[0] <<";" <<end[1] <<"]" <<endl;
	cout<<"maximum possibility = " <<possibility <<endl;
	cout<<"starting possibility = " <<refPossibility <<endl;
	cout<<"rising time = " <<risingTime <<endl;
}

//! constructor
//! @param dF:	folder containing the modelling dataset
Reasoner::Reasoner(string dF)
{
	string one_HMPn;
	float temp1;
	float temp2;
	float temp3;
	Interval *one_interval;

	datasetFolder = "/home/yeshi/catkin_ws/src/HMPdetector/Models/" + dF + "/";
	string fileName = datasetFolder + "Classifierconfig.txt";
	//DEBUG: cout<<"config file: " <<fileName <<endl;
	ifstream configFile(fileName.c_str());
	configFile >>nbM;
	//DEBUG: cout<<"nbM: " <<nbM <<endl;
	for(int i=0; i< nbM; i++)
	{
		configFile>>one_HMPn >>temp1 >>temp2 >>temp3;
		cout<<"Interval: " <<one_HMPn <<endl;
		one_interval = new Interval(one_HMPn);
		//DEBUG: one_interval->printStatus();
		setI.push_back(*one_interval);
	}
	configFile.close();
}

//! print set information
//! @return:	---
void Reasoner::printSetStatus()
{
	for(int i=0; i<nbM; i++)
		setI[i].printStatus();
}

//! set all the reasoner variables and initialize the intervals
//! @param dF:		name of the dataset to be considered
//! @return:		---
void Reasoner::buildSet(string dF)
{
	string one_HMPn;
	float temp1;
	float temp2;
	float temp3;
	Interval *one_interval;

	// delete the existing intervals
	setI.clear();

	// load the new set of intervals
	datasetFolder = "/home/yeshi/catkin_ws/src/HMPdetector/Models/" + dF + "/";
	string fileName = datasetFolder + "Classifierconfig.txt";
	//DEBUG: cout<<"config file: " <<fileName <<endl;
	ifstream configFile(fileName.c_str());
	configFile >>nbM;
	//DEBUG: cout<<"nbM: " <<nbM <<endl;
	for(int i=0; i< nbM; i++)
	{
		configFile>>one_HMPn >>temp1 >>temp2 >>temp3;
		cout<<"Interval: " <<one_HMPn <<endl;
		one_interval = new Interval(one_HMPn);
		//DEBUG: one_interval->printStatus();
		setI.push_back(*one_interval);
	}
	configFile.close();
}

//! publish the reasoner tuples on PEIS
//! @param &i:	reference to the index of the interval to be published
//! @return:	---
void Reasoner::publishReasoner(int& i)
{
	// HMP.[HMPname]
	string IntervalName = "HMP." + setI[i].HMPname;
	const char* sIntervalName = IntervalName.c_str();
	//DEBUG: cout<<"IntervalName: " <<sIntervalName <<endl;
	stringstream ntos;
	ntos<<setI[i].start[0];
	string IntervalData;
	IntervalData = "[" + ntos.str() + ";";
	ntos.str(string());
	ntos<<setI[i].start[1];
	IntervalData = IntervalData + ntos.str() + "]-[";
	ntos.str(string());
	ntos<<setI[i].end[0];
	IntervalData = IntervalData + ntos.str() + ";";
	ntos.str(string());
	ntos<<setI[i].end[1];
	IntervalData = IntervalData + ntos.str() + "]: ";
	ntos.str(string());
	ntos<<setI[i].possibility;
	IntervalData = IntervalData + ntos.str();
	const char* sIntervalData = IntervalData.c_str();
	//DEBUG: cout<<"IntervalData: " <<sIntervalData <<endl;
	peiskmt_setStringTuple(sIntervalName, sIntervalData);
}

//! report the reasoner tuples on a file
//! @param &i:	reference to the index of the interval to be published
//! @param rF:	name of the result file
//! @return:	---
void Reasoner::reportReasoner(int& i, string rF)
{
	// create result file
	ofstream outputFile;
	outputFile.open(rF.c_str(), ios_base::app);

	// HMP.[HMPname]
	string IntervalName = "HMP." + setI[i].HMPname;
	outputFile<<IntervalName.c_str() <<" "
			  <<"[" <<setI[i].start[0] <<";" <<setI[i].start[1] <<"]-"
			  <<"[" <<setI[i].end[0] <<";" <<setI[i].end[1] <<"]: "
			  <<setI[i].possibility <<endl;

	// close the result file
	outputFile.close();
}

//! update the interval of activation for one model
//! @param &i:			reference to the index of the considered model
//! @param &nSamples:	reference to the current sample
//! @param &p:			reference to the model possibility at current sample
//! @param &pp:			reference to the model possibility at previous sample
//! @param f:			flag for the publishing method (0: file, 1:PEIS)
//! @param rF:			name of the result file
//! @return:			---
void Reasoner::updateInterval(int& i,int& nS,float &p,float &pp,int f,string rF)
{
	// 1) active
	if(p > 0)
	{
		// 1.1) new active: create a new interval
		if(setI[i].open == false)
		{
			setI[i].startInterval(p, nS, pp);
			cout<<setI[i].HMPname <<": open interval" <<endl;
		}
		// 1.2.1) already active and rising
		else if(p >= setI[i].possibility)
		{
			setI[i].end[0] = nS;
			setI[i].possibility = p;
			setI[i].risingTime++;
			//DEBUG: cout<<"Rising" <<endl;
		}
		// 1.2.2) already active and descending
		else
		{
			setI[i].risingTime--;
			// if the descent is not smooth, the interval is NOT valid
			if(p > pp)
			{
				setI[i].open = false;
				cout<<setI[i].HMPname <<": false positive - NO bell shape" <<endl;
			}
			// check the simmetry of the possibility curve
			if((setI[i].risingTime == 0) && (p < setI[i].refPossibility))
			{
				setI[i].open = false;
				cout<<setI[i].HMPname <<": false positive - NO symmetry" <<endl;
			}
			// if the above constraints are satisfied, publish the result on PEIS
			if((setI[i].risingTime >= 0) && (p == setI[i].refPossibility))
			{
				// define the ending time of the interval
				setI[i].setEnd(setI[i].end[0]);

				// publish the interval info
				if (f == 0)
					// on file
					reportReasoner(i, rF);
				if (f == 1)
					// on PEIS
					publishReasoner(i);

				// close the interval
				setI[i].open = false;
			}
		}
	}
	// 2) inactive
	// (if the interval should be closed: open == true && refPossibility == 0)
	else if((setI[i].open == true) && (setI[i].refPossibility == 0))
	{
		// define the ending time of the interval
		setI[i].setEnd(setI[i].end[0]);

		// publish the interval info
		if (f == 0)
			// on file
			reportReasoner(i, rF);
		if (f == 1)
			// on PEIS
			publishReasoner(i);

		// close the interval
		setI[i].open = false;
	}
}

//! perform off-line analysis of pre-recorded models possibilities
//! @param path:		path to the possibilities & results file
//! @param testFile:	name of the possibilities file to be analyzed
//! @return:			---
void Reasoner::offlineReasoner(string path, string testFile)
{
	vector<float> possibilities;		// models possibilities
	vector<float> past_possibilities;	// models previous possibilities
	int nSamples = 0;					// number of acquired samples

	// create result file (same folder of the possibilities file)
	string rF = path + "Rres_" + testFile;

	// initialize the possibilities and PREVIOUSpossibilities
	for(int i = 0; i < nbM; i++)
	{
		possibilities.push_back(0);
		past_possibilities.push_back(0);
	}

	// read & analyze recorded possibilities one line at the time
	string pFile = path + testFile;
	ifstream pf(pFile.c_str());
	cout <<"Reading possibilities in: " <<pFile <<endl;
	while (!pf.eof())
	{
		// update the values of the past_possibilities
		for(int i = 0; i < nbM; i++)
			past_possibilities[i] = possibilities[i];

		// read the new possibilities
		for(int i = 0; i < nbM; i++)
		{
			pf>>possibilities[i];
			//DEBUG: cout<<possibilities[i] <<" ";
		}
		//DEBUG: cout<<endl;
		if (!pf)
			break;

		// extract/update the intervals of activation for each activity
		for(int i = 0; i < nbM; i++)
			updateInterval(i,nSamples,possibilities[i],past_possibilities[i],0,rF);

		nSamples = nSamples + 1;
	}
	pf.close();

	// analyze intervals that are still open at the end of the file
	for (int i = 0; i < nbM; i++)
	{
		if((setI[i].open == true) && (setI[i].refPossibility == 0))
		{
			// define the ending time of the interval
			setI[i].setEnd(setI[i].end[0]);

			// publish the interval info on file
			reportReasoner(i, rF);

			// close the interval
			setI[i].open = false;
		}
	}
}

//! perform on-line full analysis of a data stream (classifier inside)
//! @param port:	USB port for data acquisition
//! @return:		---
void Reasoner::onlineReasoner(char* port) //Online reasoner using tuple view
{
	int nSamples = 0;			// number of acquired samples
	string sample;				// current sample acquired via USB
	mat actsample;				// current sample in matrix format
	int ax, ay, az;				// accelerometer current sample components
	int gx, gy, gz;				// gyroscope current sample components
	char dev;					// flag --> device type
	string motion;				// flag --> level of motion at the wrist
	vector<float> poss;			// models possibilities
	vector<float> past_poss;	// models previous possibilities

	string waste = " ";

	// instantiate and initialize a Classifier
	string dF = datasetFolder.substr(0,datasetFolder.length()-1);
	dF = dF.substr(9);
	Classifier hC(dF);
	mat window = zeros<mat>(hC.window_size, 3);
	mat gravity = zeros<mat>(hC.window_size, 3);
	mat body = zeros<mat>(hC.window_size, 3);

	// initialize the possibilities and past possibilities
	for(int i = 0; i < nbM; i++)
	{
		poss.push_back(0);
		past_poss.push_back(0);
	}

	// set up the serial communication (read-only)
	SerialOptions options;
	options.setDevice(port);
	options.setBaudrate(9600);
	options.setTimeout(seconds(1));
	options.setParity(SerialOptions::noparity);
	options.setCsize(8);
	options.setFlowControl(SerialOptions::noflow);
	options.setStopBits(SerialOptions::one);
	SerialStream serial(options);
	serial.exceptions(ios::badbit | ios::failbit);

	// extract known activities intervals from the stream of raw acceleration data
	while(1) //Infinite loop
	{
		try
		{
			// read the current sample
			getline(serial,sample);
			istringstream stream(sample);
			stream >>dev >>ax >> ay >>az >>gx >>gy >>gz >>motion;
			actsample <<ax <<ay <<az;
			//DEBUG: cout<<"Acquired: " <<ax <<" " <<ay <<" " <<az <<" ";

			// update the window of samples to be analyzed
			hC.createWindow(actsample, window, hC.window_size, nSamples);
			if (nSamples >= hC.window_size)
			{
				// analyze the window and compute the models possibilities
				for(int i = 0; i < nbM; i++)
					past_poss[i] = poss[i];
				hC.analyzeWindow(window, gravity, body);
				hC.compareAll(gravity, body, poss);

				// publish the dynamic tuples
				hC.publishDynamic(poss); //Displays in Tuple view

				// extract/update the intervals of activation for each activity
				for(int i = 0; i < nbM; i++)
					updateInterval(i,nSamples,poss[i],past_poss[i],1,waste);
			}
		}
		catch(TimeoutException&)
		{
			serial.clear();
			cerr<<"Timeout occurred"<<endl;
		}
	}
}


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Data at ASH 2020 Annual Meeting Highlights Jazz Pharmaceuticals' Commitment to Advancing Hematology/Oncology Research
18 abstracts spanning Jazz's hematology/oncology therapeutic area to be presented
DUBLIN, Nov. 5, 2020 /PRNewswire/ -- Jazz Pharmaceuticals plc (Nasdaq: JAZZ) today announced that 11 company-sponsored abstracts, in addition to two abstracts from collaboration trials with The University of Texas MD Anderson Cancer Center (MD Anderson), one abstract from a cooperative group trial and four abstracts from investigator-sponsored trials, will be presented at the 62nd American Society of Hematology (ASH) Annual Meeting, which will be held December 5-8, 2020 as a virtual event.
"This year, we submitted and had more Jazz abstracts accepted for presentation at ASH than ever before, further demonstrating our commitment to research and innovation in hematology and oncology," said Robert Iannone, M.D., M.S.C.E., executive vice president, research and development of Jazz Pharmaceuticals. "There continues to be an urgent need for new therapeutics and regimens for people with blood cancers who have limited treatment options or who have a goal to obtain a transplant, and we remain committed to these patients through our ongoing research."
Oral presentations selected to be presented at ASH include:
Long-term outcomes and five-year results from the Phase 3 study of Vyxeos® (daunorubicin and cytarabine), also known as CPX-351, in older adults with newly diagnosed, high-risk/secondary acute myeloid leukemia (AML)
Analysis from a multinational, observational registry study evaluating treatment duration, VOD/SOS resolution and survival in patients with veno-occlusive disease/sinusoidal obstruction syndrome treated with Defitelio® (defibrotide sodium) following hematopoietic cell transplantation
Results from a Phase 2 study in collaboration with MD Anderson investigating the safety and efficacy of Vyxeos in combination with venetoclax in patients with relapsed or refractory AML
The ASH abstracts are available online at https://ash.confex.com/ash/2020/webprogram/start.html
A full list of Jazz-sponsored oral and ePoster presentations follows below:
Vyxeos Oral and ePoster Presentations
Presentation Topic
Date / Time (PST) /
Session Title /
Presentation Number
Five-Year Final Results of a Phase 3 Study of CPX-351 versus 7+3 in Older Adults with Newly Diagnosed High-Risk/Secondary Acute Myeloid Leukemia (AML): Outcomes by Age Subgroup and Among Responders
Lancet, et al.
Session Title: 615.
Acute Myeloid Leukemia: Commercially Available Therapy, Excluding Transplantation: Commercially Available Therapy, Excluding Transplantation II
Presentation Number: 635
CPX-351 Population Pharmacokinetics in Pediatric and Adult Patients with Acute Myeloid Leukemia (AML)
Wang, et al.
ePoster Presentation:
Acute Myeloid Leukemia: Commercially Available Therapy, Excluding Transplantation: Poster III
Poster Number: 2848
Quality-Adjusted Time without Symptoms of Disease and Toxicity (Q-TWiST) Analysis of CPX-351 versus 7+3 in Older Adults with Newly Diagnosed High-Risk/Secondary Acute Myeloid Leukemia (AML)
Cortes, et al.
Acute Myeloid Leukemia: Commercially Available Therapy, Excluding Transplantation: Poster II
CPX-351 Exposure-Response Analyses for Efficacy and Safety in Pediatric Patients with Relapsed or Refractory Acute Myeloid Leukemia (AML)
Session Title: 615. Acute Myeloid Leukemia: Commercially Available Therapy, Excluding Transplantation: Poster II
Long-term Outcomes of Allogeneic Hematopoietic Cell Transplantation in Patients Enrolled in CPX-351-301, a Randomized Phase 3 Study of CPX-351 versus 7+3 in Older Adults with Newly Diagnosed, High-Risk and/or Secondary AML
Uy, et al.
Session Title: 732. Clinical Allogeneic Transplantation: Results: Poster III
Analysis of Treatments and Outcomes for Patients with De Novo AML, Therapy-Related AML, and Secondary AML (Prior MDS and CMML) Diagnosed in England between 2011 and 2016 Using Hospital Episode Statistics®
Legg, et al.
Acute Myeloid Leukemia: Clinical Studies: Poster II
Patient Experiences with Liposomal Daunorubicin and Cytarabine (CPX-351) versus Conventional Induction Regimens: An Analysis of Patient-Reported Outcomes Data from a Prospective Trial
LeBlanc, et al.
Outcomes Research –Malignant Conditions (Myeloid Disease): Poster II
V-FAST: A Phase 1b Master Trial to Investigate CPX-351 Combined with Various Targeted Agents in Patients with Previously Untreated Acute Myeloid Leukemia
Lin, et al.
Session Title: 615
Acute Myeloid Leukemia: Commercially Available Therapy, Excluding Transplantation: Poster I
Exploratory Analysis of the Efficacy and Safety of CPX-351 versus 7+3 by European LeukemiaNet (ELN) 2017 Risk Groups in a Phase 3 Study of Older Adults with High-Risk/Secondary Acute Myeloid Leukemia
Prebet, et al.
Post-Marketing Observational Study to Assess the Incidence of Infusion-Related Reactions in Adult Patients with Therapy-Related Acute Myeloid Leukemia (AML) or AML with Myelodysplasia-Related Changes Who Were Treated with CPX-351
Jacoby, et al.
Accepted for publication only
Defitelio Oral and ePoster Presentations
Treatment Duration, Symptom Resolution, and Survival in Defibrotide-Treated Patients with Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome after Hematopoietic Cell Transplantation: Analysis of a Multinational, Prospective, Observational Registry Study
Locatelli, et al.
Clinical Allogeneic Transplantation: Conditioning Regimens, Engraftment, and Acute Transplant Toxicities
Final Primary Results from the DEFIFrance Registry Study: Effectiveness and Safety of
Defibrotide in the Treatment of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction
Syndrome after Hematopoietic Cell Transplantation
Mohty, et al.
Clinical Allogeneic Transplantation: Conditioning Regimens, Engraftment, and Acute Transplant Toxicities: Poster II
Additionally, data from the following collaboration and investigator-sponsored trials on Vyxeos and Defitelio will be presented:
Phase II Study of CPX–351 Plus Venetoclax in Patients with Acute Myeloid Leukemia (AML)
Kadia, et al.
Acute Myeloid Leukemia: Novel Therapy, Excluding Transplantation: Novel Combination Therapies in Treatment of Newly Diagnosed AML
Presentation Number: 28
Liposomal Cytarabine and Daunorubicin (CPX–351) in Combination with Gemtuzumab Ozogamicin (GO) in Relapsed Refractory (R/R) Patients with Acute Myeloid Leukemia (AML) and Post–Hypomethylating Agent (Post–HMA) Failure High–Risk Myelodysplastic Syndrome (HR–MDS)
Perez, et al.
Session Title: 613. Acute Myeloid Leukemia: Clinical Studies: Poster I
Poster Number: 987
Initial Results of a Phase 1 Dose Escalation Study of CPX-351 for Patients with Int-2 or High risk IPSS Myelodysplastic Syndromes (MDS) and Chronic Myelomonocytic Leukemia (CMML) After Failure to Hypomethylating Agents
Montalban Bravo, et al.
Higher Dose of CPX-351 is Associated With Prolonged Hematologic Recovery:
Results from an Interim Safety Analysis of the Randomized, Phase III AMLSG 30-18 Trial
Gaidzik, et al.
Session Title: 616. Acute Myeloid Leukemia: Novel Therapy, excluding Transplantation: Poster I
Outpatient Vyxeos Induction without Planned Admission for Select Patients with
Secondary Acute Myeloid Leukemia (sAML) Is Safe and Yields Healthcare Resource Savings
Keiffer, et al.
A Phase I/II Trial of CPX-351 + Palbociclib in Patients with Acute Myeloid Leukemia
Nazha, et al.
Session Title: 616. Acute Myeloid Leukemia: Novel Therapy, excluding Transplantation: Poster II
A Phase II Study of CPX-351 as a Novel Therapeutic Approach for Patients with Myelodysplastic Syndromes (MDS) after Hypomethylating Agent Failure
Preliminary Results of a Phase II Study to Determine the Safety of Defibrotide in Children
and Adolescents with Sickle Cell Disease-Associated Acute Chest Syndrome (IND 127812)
Milner, et al.
Hemoglobinopathies, Excluding Thalassemia – Clinical: Poster I
A Pilot Trial of Pre-Transplant Risk Stratification and Prophylactic Defibrotide to Prevent Serious
Thrombotic Microangiopathy in High-Risk Pediatric Hematopoietic Stem Cell Transplant Patients
Higham, et al.
Clinical Allogeneic Transplantation: Conditioning Regimens, Engraftment, and Acute Transplant Toxicities: Poster III
Defibrotide for the Treatment of Endotheliitis Complicating Sars-Cov-2 Infection: Rationale and Ongoing Studies as Part of the International Defacovid Study Group
Moraleda, et al.
About Vyxeos® (daunorubicin and cytarabine)
In the U.S., Vyxeos® (daunorubicin and cytarabine) is a liposomal formulation of a fixed combination of daunorubicin and cytarabine for intravenous infusion that represents the first, only and most proven chemotherapy treatment option specifically for two types of high-risk, secondary acute myeloid leukemia (AML): newly diagnosed therapy-related AML (t-AML) and AML with myelodysplasia-related changes (AML-MRC). In Europe, Vyxeos® Liposomal (daunorubicin/cytarabine) is indicated for the treatment of adults with newly diagnosed, therapy-related acute myeloid leukemia (t-AML) or AML with myelodysplasia-related changes (AML-MRC). Backed by a robust clinical development program including Phase 3 data, Vyxeos is currently approved in more than 30 countries, and Jazz continues to work with regulatory authorities worldwide to bring this innovative therapy to appropriate patients.
Important Safety Information for Vyxeos Liposomal
Vyxeos Liposomal has different dosage recommendations from other medications that contain daunorubicin and/or cytarabine. Do not substitute Vyxeos Liposomal for other daunorubicin- and/or cytarabine- containing products.
Vyxeos Liposomal should not be given to patients who have a history of serious allergic reaction to daunorubicin, cytarabine or any of its ingredients.
Vyxeos Liposomal can cause a severe decrease in blood cells (red and white blood cells and cells that prevent bleeding, called platelets) which can result in serious infection or bleeding and possibly lead to death. Your doctor will monitor your blood counts during treatment with Vyxeos Liposomal. Patients should tell the doctor about new onset fever or symptoms of infection or if they notice signs of bruising or bleeding.
Vyxeos Liposomal can cause heart-related side effects. Tell your doctor about any history of heart disease, radiation to the chest, or previous chemotherapy. Inform your doctor if you develop symptoms of heart failure such as:
swelling or fluid retention, especially in the feet, ankles or legs
Vyxeos Liposomal may cause allergic reactions including anaphylaxis. Seek immediate medical attention if you develop signs and symptoms of anaphylaxis such as:
swelling of the face, lips, mouth, or tongue
Vyxeos Liposomal contains copper and may cause copper overload in patients with Wilson's disease or other copper-processing disorders.
Vyxeos Liposomal can damage the skin if it leaks out of the vein. Tell your doctor right away if you experience symptoms of burning, stinging, or blisters and skin sores at the injection site.
Vyxeos Liposomal can harm your unborn baby. Inform your doctor if you are pregnant, planning to become pregnant, or nursing. Do not breastfeed while receiving Vyxeos Liposomal. Females and males of reproductive potential should use effective contraception during treatment and for 6 months following the last dose of Vyxeos Liposomal.
The most common side effects were bleeding events, fever, rash, swelling, nausea, sores in the mouth or throat, diarrhea, constipation, muscle pain, tiredness, stomach pain, difficulty breathing, headache, cough, decreased appetite, irregular heartbeat, pneumonia, blood infection, chills, sleep disorders, and vomiting.
Please see full Prescribing Information for Vyxeos Liposomal including BOXED Warning, and visit www.Vyxeos.com for additional information.
About Defitelio® (defibrotide sodium)
In the U.S., Defitelio® (defibrotide sodium) injection 80mg/mL received U.S. Food and Drug Administration (FDA) marketing approval on March 30, 2016 for the treatment of adult and pediatric patients with hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), with renal or pulmonary dysfunction following hematopoietic stem-cell transplantation (HSCT) and is the first and only FDA-approved therapy for patients with this rare, potentially fatal complication. Defitelio is not approved for the prevention of VOD.
Please see full Prescribing Information for Defitelio.
In Europe, defibrotide is marketed under the name Defitelio® ▼ (defibrotide). In October 2013, the European Commission granted marketing authorization to Defitelio under exceptional circumstances for the treatment of severe VOD in patients undergoing HSCT therapy. It is the first and only approved treatment in Europe for severe VOD. In Europe, Defitelio is indicated in patients over one month of age. It is not indicated in patients with hypersensitivity to defibrotide or any of its excipients or with concomitant use of thrombolytic therapy.
▼This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system found under section 4.8 of the SmPC.
(http://www.ema.europa.eu/ema/index.jsp?curl=/pages/medicines/human/medicines/002393/human_med_001646.jsp)
Defibrotide is currently being investigated in two Phase 2 trials for the prevention of acute Graft-versus-Host-Disease (aGvHD) and the prevention of neurotoxicity in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) receiving CAR T-cell therapy.
Important Safety Information for Defitelio
Defitelio should not be given to patients who are:
Currently taking anticoagulants or fibrinolytics
Allergic to Defitelio or any of its ingredients
Defitelio may increase the risk of bleeding in patients with VOD and should not be given to patients with active bleeding. During treatment with Defitelio, patients should be monitored for signs of bleeding. In the event that bleeding occurs during treatment with Defitelio, treatment should be temporarily or permanently stopped. Patients should tell the doctor right away about any signs or symptoms of hemorrhage such as unusual bleeding, easy bruising, blood in urine or stool, headache, confusion, slurred speech, or altered vision.
Defitelio may cause allergic reactions including anaphylaxis. Patients who develop signs and symptoms of anaphylaxis such as trouble breathing, severe itching, skin rash or hives, or swelling of the face, lips, mouth or tongue should seek medical attention immediately.
The most common side effects of Defitelio are decreased blood pressure, diarrhea, vomiting, nausea and nose bleeds.
Please see full Prescribing Information for Defitelio and visit www.Defitelio.com for additional information.
About Jazz Pharmaceuticals
Jazz Pharmaceuticals plc (Nasdaq: JAZZ) is a global biopharmaceutical company dedicated to developing and commercializing life-changing medicines that transform the lives of patients with serious diseases - often with limited or no options. We have a diverse portfolio of marketed medicines and novel product candidates, from early- to late-stage development, in key therapeutic areas. Our focus is in neuroscience, including sleep and movement disorders, and in oncology, including hematologic malignancies and solid tumors. We actively explore new options for patients including novel compounds, small molecule advancements, biologics and innovative delivery technologies. Jazz is headquartered in Dublin, Ireland and has employees around the globe, serving patients in more than 90 countries. For more information, please visit www.jazzpharmaceuticals.com and follow @JazzPharma on Twitter.
Jacqueline Kirby, Vice President, Corporate Affairs & Government Relations
Ireland +353 1 697 2141 U.S. +1 215 867 4910
Kathee Littrell, Vice President, Investor Relations
View original content to download multimedia:http://www.prnewswire.com/news-releases/data-at-ash-2020-annual-meeting-highlights-jazz-pharmaceuticals-commitment-to-advancing-hematologyoncology-research-301167053.html
SOURCE Jazz Pharmaceuticals plc
Jazz Pharmaceuticals Announces Participation at Jefferies Virtual London Healthcare Conference
Were These Hedge Funds Right About Betting On Jazz Pharmaceuticals Plc (JAZZ)?
What We Learned About Jazz Pharmaceuticals' (NASDAQ:JAZZ) CEO Pay
Jazz Pharmaceuticals Up on Third Quarter Earnings Beat
--Analyst Actions: Barclays Adjusts Price Target for Jazz Pharmaceuticals to $233 From $225, Maintains Overweight Rating
--Analyst Actions: JP Morgan Adjusts Price Target for Jazz Pharmaceuticals to $178 From $175, Maintains Overweight Rating
--Analyst Actions: Wells Fargo Adjusts Price Target on Jazz Pharmaceuticals to $184 From $171, Reiterates Overweight Rating
Analyst Actions: HC Wainwright Adjusts Jazz Pharmaceuticals' Price Target to $195 From $185, Keeps at Buy

redpajama_set_name: RedPajamaCommonCrawl


text:
Dave Berry >
Dave Berry Fun Facts, Quotes and Tweets
Follow Dave Berry
Quote: "I have been with my new boyfriend for a few months now and it's going really well. He's not in the industry. We won't move in together yet as I live with my sister and I'm happy with the way things are." British pop star Heidi Range goes public with her new partner, 18 months after announcing her engagement to U.K. radio host Dave Berry had come to an end.
Fact: Soul star Adele was celebrating following her set at London's iTunes Festival on Thursday (07Jul11) - she was told backstage by British TV presenter Dave Berry that her hit track Someone Like You had become the first single to sell more than a million copies in the U.K. this decade. She declared: "I didn't know that, that's amazing! I didn't even know we'd done 500,000!"
Dave Berry Quick Links News Pictures Quotes RSS
Dave Berry Quick Links
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People Index: 0 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z


The Supreme Court has just given judgment (24 October 2012) in Rubin and another v Eurofinance SA and others and New Cap Reinsurance Corporation (In Liquidation) and another (Respondents/Cross Appellants) v A E Grant and others as Members of Lloyd's Syndicate 991 for the 1997 Year of Account and another (Appellants/Cross Respondents).
The decision is important, because since the Court of Appeal decision in Rubin, which was followed in New Cap, it appeared that a different rule applied to enforcement of judgments in foreign insolvency proceedings, as opposed to other foreign judgments.
The Court of Appeal made a clear distinction between the principals of English private international law relating to the enforcement of foreign judgments, when dealing with cross-border insolvency, as opposed to other cases.
Part of the rationale is that bankruptcy proceedings should have universal application and no creditor should have an advantage, because he lives in a jurisdiction where more of the assets orfewer of the creditors are situated.
Accordingly, when dealing with cross-border insolvency, the Court of Appeal considered that different considerations apply to the enforcement of foreign judgments than in other cases.
The case was argued before the Supreme Court in May 2012 and judgment was given on 24 October 2012.
"13. … Judgments in rem and in personam are judicial determinations of the existence of rights: in the one case, rights over property and in the other, rights against a person. When a judgment in rem or in personam is recognised by a foreign court, it is accepted as establishing the right which it purports to have determined, without further inquiry into the grounds upon which it did so. The judgment itself is treated as the source of the right.
First Case―If the person against whom the judgment was given was, at the time the proceedings were instituted, present in the foreign country.
Second Case―If the person against whom the judgment was given was claimant, or counterclaimed, in the proceedings in the foreign court.
Third Case―If the person against whom the judgment was given submitted to the jurisdiction of that court by voluntarily appearing in the proceedings.
"108. The principles in the Dicey Rule have never received the express approval of the House of Lords or the UK Supreme Court and the leading decisions remain Adams v Cape Industries plc  Ch 433 and the older Court of Appeal authorities which it re-states or re-interprets. But there can be no doubt that the references by the House of Lords in the context of foreign judgments to the foreign court of "competent jurisdiction" are implicit references to the common law rule: eg In re Henderson, Nouvion v Freeman (1890) 15 App Cas 1, 8; Owens Bank Ltd v Bracco  2 AC 443, 484.
113. But there is no suggestion on this appeal that the principles embodied in the Dicey Rule should beabandoned. Instead the Rubin respondents suggest that the principles should not apply to foreign insolvency orders.
115. The question, therefore, is one of policy. Should there be a more liberal rule for avoidance judgments in the interests of the universality of bankruptcy and similar procedures? In my judgment the answer is in the negative for the following reasons.
116. First, although I accept that it is possible to distinguish between avoidance claims and normal claims, for example in contract or tort, it is difficult to see in the present context a difference of principle between a foreign judgment against a debtor on a substantial debt due to a company in liquidation and a foreign judgment against a creditor for repayment of a preferential payment. The respondents suggest that a person who sells goods to a foreign company accepts the risk of the insolvency legislation of the place of incorporation. Quite apart from the fact that the suggestion is wholly unrealistic, why should the seller/creditor be in a worse position than a buyer/debtor?
117. The second reason is that if there is to be a different rule for foreign judgments in such proceedings as avoidance proceedings, the court will have to ascertain (or, more accurately, develop) two jurisdictional rules. There are two aspects of jurisdiction which would have to be satisfied if a foreign insolvency judgment or order is to be outside the scope of the Dicey Rule: the first is the requisite nexus between the insolvency and the foreign court, and the second is the requisite nexus between the judgment debtor and the foreign court.
The Court was very definite in its answer to the policy question.
"128. In my judgment, the dicta in Cambridge Gas and HIH do not justify the result which the Court of Appeal reached. This would not be an incremental development of existing principles, but a radical departure from substantially settled law. There is a reason for the limited scope of the Dicey Rule and that is that there is no expectation of reciprocity on the part of foreign countries. Typically today the introduction of new rules for enforcement of judgments depends on a degree of reciprocity. The EC Insolvency Regulation and the Model Law were the product of lengthy negotiation and consultation.
129. A change in the settled law of the recognition and enforcement of judgments, and in particular the formulation of a rule for the identification of those courts which are to be regarded as courts of competent jurisdiction (such as the country where the insolvent entity has its centre of interests and the country with which the judgment debtor has a sufficient or substantial connection), has all the hallmarks of legislation, and is a matter for the legislature and not for judicial innovation. The law relating to the enforcement of foreign judgments and the law relating to international insolvency are not areas of law which have in recent times been left to be developed by judge-made law. As LordBridge of Harwich put it in relation to a proposed change in the common law rule relating to fraud as a defence to the enforcement of a foreign judgment, "if the law is now in need of reform, it is for the legislature, not the judiciary, to effect it": Owens Bank Ltd v Bracco  2 AC 443, 489.
130. Furthermore, the introduction of judge-made law extending the recognition and enforcement of foreign judgments would be only to the detriment of United Kingdom businesses without any corresponding benefit. I accept the appellants' point that if recognition and enforcement were simply left to the discretion of the court, based on a factor like "sufficient connection," a person in England who might have connections with a foreign territory which were only arguably "sufficient" would have to actively defend foreign proceedings which could result in an in personam judgment against him, only because the proceedings are incidental to bankruptcy proceedings in the courts of that territory. Although I say nothing about the facts of the Madoff case, it might suggest that foreigners who have bona fide dealings with the United States might have to face the dilemma of the expense of defending enormous claims in the United States or not defending them and being at risk of having a default judgment enforced abroad.
Whilst the decision is undoubtedly a disappointment to insolvency practitioners, it has the welcome benefit of retaining rules on the enforcement of foreign judgments which have developed over nearly two centuries and are predictable, and avoided the court having to "ascertain (or, more accurately, develop) two jurisdictional rules. There are two aspects of jurisdiction which would have to be satisfied if a foreign insolvency judgment or order is to be outside the scope of the Dicey Rule: the first is the requisite nexus between the insolvency and the foreign court,and the second is the requisite nexus between the judgment debtor and the foreign court." (judgment at paragraph 117).
For the position on enforcement of foreign judgments generally, see Enforcement of US Judgments in England.


text:
'use strict';

// Replies controller

//old
// angular.module('replies').controller('RepliesController',
//   ['vm', '$stateParams', '$location', 'Authentication', 'Replies', 'RecursionHelper',
//   function (vm, $stateParams, $location, Authentication, Replies, RecursionHelper) {

angular
.module('replies')
.controller('RepliesController', RepliesController);

RepliesController.$inject = ['$scope', '$state', 'Authentication', 'Replies', 'RecursionHelper'];
function RepliesController($scope, $state, Authentication, Replies, RecursionHelper) {

  var vm = this;
  vm.authentication = Authentication;
  vm.articleId = $state.params.articleId;

  // Init the new top level reply Form
  vm.topReply = {};
  vm.topReplyCollapsed = true;
  vm.topReplyAvailable = (Authentication.user);

  // There is probably a better way to do this. I'm using these helper functions
  // in conjunction with the ui.bootsrap "collapse" tag to show/hide things
  vm.showReplyForm = function(replyId) {
    vm.currentReplyId = replyId;
  };
  vm.cancelReply = function() {
    vm.currentReplyId = null;
  };

  vm.prepareDelete = function(replyId) {
    vm.replyToDelete = replyId;
  };
  vm.cancelDelete = function() {
    vm.replyToDelete = null;
  };

  vm.prepareEdit = function(reply) {
    reply.newContent = reply.content;
    vm.replyToEdit = reply._id;
  };
  vm.cancelEdit = function() {
    vm.replyToEdit = null;
  };

  vm.cancelTopReply = function() {
    vm.topReply.content = '';
  };

  // vm.prepareReport = function(replyId) {
  //   vm.replyToReport = replyId;
  // };
  // End show/hide stuff

  // CRUD Operations
  // Create a new top level reply
  vm.createTop = function() {
    var articleId = vm.articleId;
    vm.topReply.error = null;
    var newTopReply = vm.topReply;

    var reply = new Replies(newTopReply);
    reply.article = articleId;
    reply.nestedLevel = 1;

    reply.$save(function(response) {
      vm.replies.unshift(response);
      vm.topReply = {};
      vm.topReplyAvailable = false;
    }, function(errorResponse) {
      vm.topReply.error = errorResponse.data.message;
    });
  };

  // Create new Reply where replyId is the _id of the reply we're replying to
  vm.create = function (currentReply) {
    currentReply.error = null;
    // First make sure there's actually something in the reply
    if (!currentReply.newReply) {
      currentReply.error = 'The reply was empty!';
      return false;
    }
    // Now check that they haven't somehow replied to a level 9 reply
    var newReplyLevel = currentReply.nestedLevel + 1;
    if (newReplyLevel > 9) {
      currentReply.error = 'how the hell did you do that?';
      return false;
    }

    // Construct a new reply to send to the api
    var reply = new Replies({
      content: currentReply.newReply,
      article: currentReply.article,
      replyTo: currentReply._id,
      nestedLevel: newReplyLevel
    });

    // Use resource to hit the server api, then push the reply into the current view
    reply.$save(function (response) {
      currentReply.replies.unshift(response);
      currentReply.newReply='';
      vm.currentReplyId = null;
    }, function (errorResponse) {
      currentReply.error = errorResponse.data.message;
    });
  };

  // Remove existing Reply
  vm.remove = function (reply) {
    if (reply) {
      var deadManWalking = new Replies(reply);
      deadManWalking.$remove({},
        //success
        function(value){
          // brute force method of removing the reply from view
          // vm.find();

          // TODO: find a way to remove this one directive rather than just collapsing it
          reply.isDeleted = true;
        },
        //error
        function(error){
          reply.error = error.data.message;
        }
      );
    }
  };

  // Update existing Reply
  vm.update = function (currentReply) {
    currentReply.error = null;

    if (!currentReply.newContent) {
      currentReply.error = 'The reply was empty!';
      return false;
    }
    if (currentReply.newContent === currentReply.content) {
      currentReply.error = 'You did not change anything!';
      return false;
    }

    var reply = new Replies(currentReply);
    reply.content = currentReply.newContent;

    reply.$update(function (response) {
      currentReply.content = response.content;
      currentReply.edited = response.edited;
      vm.replyToEdit = null;
    }, function (errorResponse) {
      currentReply.error = errorResponse.data.message;
    });
  };

  // Find a list of Replies
  vm.find = function () {
    var articleId = $state.params.articleId;

    Replies.query({ 'article' : articleId }, function(response) {
      vm.replies = response;
      // Init Toggles
      // TODO: do this reply toggle init better
      vm.isCollapsed = {};
      angular.forEach(vm.replies, function(reply){
        vm.isCollapsed[reply._id] = false;
        angular.forEach(reply.replies, function(reply){
          vm.isCollapsed[reply._id] = true;
          angular.forEach(reply.replies, function(reply){
            vm.isCollapsed[reply._id] = false;
            angular.forEach(reply.replies, function(reply){
              vm.isCollapsed[reply._id] = false;
              angular.forEach(reply.replies, function(reply){
                vm.isCollapsed[reply._id] = false;
                angular.forEach(reply.replies, function(reply){
                  vm.isCollapsed[reply._id] = false;
                  angular.forEach(reply.replies, function(reply){
                    vm.isCollapsed[reply._id] = false;
                    angular.forEach(reply.replies, function(reply){
                      vm.isCollapsed[reply._id] = false;
                      angular.forEach(reply.replies, function(reply){
                        vm.isCollapsed[reply._id] = false;
                      });
                    });
                  });
                });
              });
            });
          });
        });
      });
    });
  };
}

redpajama_set_name: RedPajamaGithub


It's time to announce the winner for my week participating in Growing in Unity!
I want to thank everyone for their lovely comments. So many wonderful reflections from the questions I posed. Your words made me smile and learn a little about each of you. It's so nice to take a moment and appreciate all our memories, wishes for the future, and places we want to see ourselves go.
Okay, now, without delay. I used RANDOM.ORG to generate the random numbers.
The first random number was for the DAY, which produced the number 4. And that's why I have the glittery starfish image!
And then came the post!
Drumroll! The winner is Lindsey, from Bashful Blogging! Lindsey, give Unity a call and tell them what two Itty Bitty stamps you want!
Everyone else, let's all go bombard her blog with congratulatory messages! And again, thanks for all the wonderful comments this past week!
Woohoow for Lindsey! Great week last week, Rebecca!
3 Girl Jam - Design Team Call!


The Timbers Hotel is truly one of "Denver's best kept secrets!" Stepping through our front doors, you are transformed into Colorado's contemporary Western decor, ultimately relaxing and pleasantly soothing ambience.
The Lobby Lounge is the perfect gathering venue for family, friends, or business associates.
24-hour upscale free Fitness Center.
24-hour free Business Center with computer, fax, print, and copy.
The award winning Peoria Grill serving dinner, and room service and/or To Go orders.


text:
package influxdb

import (
	"fmt"
	"testing"

	"github.com/hashicorp/terraform/helper/resource"
	"github.com/hashicorp/terraform/terraform"
	"github.com/influxdata/influxdb/client"
)

func TestAccInfluxDBDatabase(t *testing.T) {
	resource.Test(t, resource.TestCase{
		Providers: testAccProviders,
		Steps: []resource.TestStep{
			resource.TestStep{
				Config: testAccDatabaseConfig,
				Check: resource.ComposeTestCheckFunc(
					testAccCheckDatabaseExists("influxdb_database.test"),
					resource.TestCheckResourceAttr(
						"influxdb_database.test", "name", "terraform-test",
					),
				),
			},
		},
	})
}

func testAccCheckDatabaseExists(n string) resource.TestCheckFunc {
	return func(s *terraform.State) error {
		rs, ok := s.RootModule().Resources[n]
		if !ok {
			return fmt.Errorf("Not found: %s", n)
		}

		if rs.Primary.ID == "" {
			return fmt.Errorf("No database id set")
		}

		conn := testAccProvider.Meta().(*client.Client)

		query := client.Query{
			Command: "SHOW DATABASES",
		}

		resp, err := conn.Query(query)
		if err != nil {
			return err
		}

		if resp.Err != nil {
			return resp.Err
		}

		for _, result := range resp.Results[0].Series[0].Values {
			if result[0] == rs.Primary.Attributes["name"] {
				return nil
			}
		}

		return fmt.Errorf("Database %q does not exist", rs.Primary.Attributes["name"])
	}
}

var testAccDatabaseConfig = `

resource "influxdb_database" "test" {
    name = "terraform-test"
}

`


Shop for the latest and greatest in Green Bay Packers Jerseys from the NFL Shop. You can find a variety of Jerseys for men, women and kids in sizes for everyone. We carry official Green Bay Packers Nike Elite Jerseys so you can wear the same gear as your favorite players and also stock a full collection of Packers Nike Limited and Nike Game Jerseys. We also carry a variety of other jerseys including Green Bay Packers Replica Jerseys, Authentic Jerseys or even Packers Vintage Jerseys so you can wear the jerseys of your favorite Packers player from years past. No matter what style you are shopping for NFL Shop is your place to find official Green Bay Packers Jerseys.


A perfect game for the bachelorette and her entourage! Everyone simply chooses a card and scratches off one set of lips from each row to determine What? Who? And How? Put your inhibitions aside and break out the camera! Each package comes with 12 scratch-style lottery cards.


This has happened to me more than once, and each time it happens I don't have an immediate answer. I think "yeah, she's right, the instigator needs some mechanical incentive to actually do said instigating." Then I fret over it and try to come up with a non-character-centric system of conflict-introduction currency… and then I sit back and ask myself: Why?
Looking at the other side of the coin, most GM-run games out there have no such conflict currency. The GM has the right to throw challenges and encounters at the players left and right, and gains no specific mechanical reward for doing so. There is no limited pool of bad guys to use, or set currency of "challenge points" with which the GM must purchase new conflicts. No one is keeping a point tally of who does what, or why, and there is no winner. Obstacles appear when they must, players overcome them, and the GMs get no mechanically-tangible rewards for continuing this process.
So I ask you: do you believe that a GM-less game of mostly-cooperative character-driven storytelling should require such a conflict incentive? Why or Why Not?
1 I am aware that D&D and some other games have Challenge Ratings and Encounter Levels and the like that serve to limit the power of most in-game adversity, but those fit more as pacing mechanics than conflict incentives.
2 I haven't played all that many GM-less games, but the less-than-a-handful that I have played have all tangibly rewarded players for introducing conflict. I'm not sure which others are out there, and which ones do and do not. Please, educate me!
I'm a little hesitant at the idea of DM-less games. I can't help but think it will end up like Toon or Paranoia, where the sole situation is screwing over the other player. And while that can work for a board game, or a one-off situation, a campaign of 'it's Thursday night, time for the game where Bob screws with me all night' doesn't sound that appealing.
I'm also puzzled how such a thing could work, as there has to be someone who comes up with the basic plot to unleash upon players. Draw a random situation from a pile of generic conflicts? Have everyone take turns bringing something that time? A DM is much more then a conflict generator, or the other that the players are conflicting with. He is the arbiter of unclear situations, adapts situations to the group, comes up with new situations, and provides the hundreds of other personalities that are not the PCs. Frankly, I have no idea how a DM-less game could work, unless it was something isolated from everyone else (Everyone in a liferaft. Thunderdome).
I personally hate challenge rating systems, as they don't give a good overview. PCs vs. One Kobold? PCs will annilhate him. PCs have to capture, not kill that Kobold? Harder. PC's have to track the Kobold down through his maze of Kobold-sized tunnels, including traps, switchbacks, and hidden passages which the Kobold knows well? That's a different story altogether.
I once ran a game where the group of PCs ran into a group of bad guys in a library. The PCs massively outpowered them in terms of level and power. But I had the baddies run smart. The 'rogue' of the group kept sneaking up and backstabbing, then running and hiding. The archer sat in the balcony above and sniped whenever the PCs stuck their heads out for too long. And the 'fighter' type, who would have been mauled had he stood and fought, instead kept knocking bookshelves over onto the party. Altogether, it wasn't very dangerous to the party, but with the GM on their side, and a bit of smart playing, three throwaway characters sparked a quite interesting battle and a challenge much higher then their level would suggest.
The problem is defining 'conflict'. A group of Orcs, sure. What about winds while the PCs are climbing a cliff? How about the evil mastermind getting a proclamation from the king? Enemy spies breaking into the secret lair? Random things, like their car breaking down or portable computer batteries running out?
A good example of a GM-less game, for this discussion, is one called Ocean. Each player has equal narrative authority, and can take the reins of the story at any time. In Ocean, each player has a character, and due to the setup of the scenario, each character has one other character that they feel the need to protect, and another character that they instinctively distrust.
Ocean's in-game currency takes the form of "Bonus Dice." Bonus dice are spent to insert usable tools, aid in future tests, and buy "clues" to what is going on in the story (allowing the player to narrate a concrete fact). You only ever get bonus dice for yourself, however, when _other_ players win or lose tests. If the character who feels the need to protect you wins a test, you can get bonus dice. Likewise, if the character who distrusts you loses a test, you can get bonus dice.
This creates a hard-coded incentive for players to introduce conflicts for other players to overcome. Thus if you want to get some bonus dice, you need to make sure that both the character who trusts you and the character who distrusts you have a lot to do, and plenty of opportunities to roll the dice. Everyone at the table has that same incentive. It works well.
My question, though: is such an incentive always necessary? Why would the joy of creating a good story and fulfilling the social contract not be incentive enough?
As for the GM's other roles, those can just as easily be shared by the group as a whole. The group should be trusted to arbitrate its own disputes. The group should be trusted to create its own situations. The group should be trusted to collaborate. And each player who buys into this social contract should be expected to bring their weight in ideas and imagination to the experience.
Something to consider is that GM Bennies in Savage Worlds are not an actual reward for the GM. They're merely another specific tool at her otherwise limitless disposal. The GM doesn't really need those bennies so much when she has limitless authority to throw more bad guys into the fray. After all, the "dungeon" is stocked with as many monsters as she sees fit, and she can throw in more without pause, to her heart's content. The bennies are just another tool to allow those monsters more chances of success, but they aren't rewards. She doesn't earn them by actually doing anything other than existing at the table. She doesn't gain any kind of tangible benefit from introducing more conflict, other than the personal joy she derives from creating adversity.
As for your definition of conflict, yes, all of those indeed apply. Essentially, a conflict exists when there is something you want/need to do,and something else is in your way. If you need to get to the end of a dark hall and you are afraid of the dark, that is a conflict. Strong winds while climbing can be a conflict.
I get the impression you don't play all that many indie games =).
I think you use a mechanic similar to Ocean in CC. It's alright, but it does make a constrained framework that I find a little odd (moreso then the 'hey, I met these five guys in the bar, now we are off on adventures!'). It frankly is more fun when rivalries develop naturally.
The more I think of it, the more I like the Descent 'buy bad things' idea. Less as a GM incentive, but it could be rigged to be a player de-incentive. Say that the 'doom count' increases by one token per turn. For any adventure/game, the group (or nominal GM) sets up the encounters. If the count reaches X point, then the game ends in a spectacular fashion (Nazis invade, ship loses power, rocks fall…) so the group wants to spend the points to prevent that from happening.
Example: You have a group of five people trying to get across the forest. There is a deck of say ten encounters that could happen. In the first few turns, they get rid of the 'easy' challenges. Crossing a river, wolf attack and so on. But toward the end, their points are building up, and only the hard encounters remain. So they have to decide whether to risk facing the dragon or try and barrel through before the time is up.
…It still sounds boardgame-y to me.
In Cannibal Contagion, the GM-Player paradigm is present. The CiC (the GM) has no real mechanical incentive to challenge the players, other than to kill them. If the CiC does well, she _might_ get some extra challenge tokens as post-conflict boons, but that is pretty random, and not at all guaranteed. The social contract of CC sets the expectation that the CiC will try and kill the survivors often, and in horrible ways, so the primary incentive for playing up that role is the sheer joy of leading the characters to a suitably gruesome fate.
I think you might be talking about the whole "Mad Half" part, though. In that case, there still isn't all that much mechanical incentive for the Mad Half to play their part. Their role is to tempt the other player with power, in exchange for that character going more insane. It gives the Mad Half no mechanical boon, however, outside of the integral joy of screwing with another player. But again, this is all part of the game's established premise, and as such the cross-table screwing is expected and encouraged by everyone present; in other words, it's the whole reason they're paying that specific game.
Thankfully, CC has no real "challenge rating" system. The closest things are the _extremely_ (and intentionally) eyeballed "Threat Ratings" of the game's enemies, but even those are random enough so that the weakest zombie could wipe the floor with the party, and the Big Boss might actually turn out to be a total pushover. But again, that's intentional, and all part of the fiction of the inspirational material.
While I've never played Descent, what you describe sounds a lot like RuneBound, which I have played, and which I understand is something of the "Descent Clone" style of board game. Or more specifically, the Midnight-themed version of that game, where there's this doom countdown thing, and if it ever reaches the end, the evil god wins. But in that situation, the guy playing the role of the Evil God obviously has a mechanical incentive for the players to lose: each time they fail, he gets closer to winning. Again, this guy works more as a GM, despite it being a board game.
This does all tie into my current design project, but I'm not totally ready to go into bigger detail on that just yet.


de Bakker, J.W, & van Leeuwen, J. (1983). Foundations of computer science IV : distributed systems : [4th advanced course on the foundations of computer science, held in Amsterdam, 14-25.06.1982], part 2: Semantics and logic. MC Tracts. Centrum Voor Wiskunde en Informatica.


text:
Джорджо Гольдони (; ) — итальянский волейболист. Участник летних Олимпийских игр 1976 года.

Биография
Джорджо Гольдони родился 19 ноября 1954 года в итальянском городе Модена.

В 1970—1979 годах играл в волейбол за «Панини» из Модены, в составе которого трижды становился чемпионом Италии (1972, 1974, 1976), а также завоевал Кубок страны в 1979 году. После этого перебрался в «Сантал» из Пармы, с которым стал чемпионом 1982 года. Впоследствии вернулся в «Панини», выиграв в сезоне-1984/85 золото чемпионата и Кубок Италии.

8 апреля 1974 года дебютировал в сборной Италии в товарищеском матче с Финляндией (3:0).

В 1974 году участвовал в чемпионате мира в Мехико, где итальянцы заняли 19-е место.

В 1976 году вошёл в состав сборной Италии по волейболу на летних Олимпийских играх в Монреале, занявшей 8-е место. Провёл 5 матчей, набрал 2 очка в поединке со сборной Бразилии.

После Олимпиады за сборную не выступал, проведя в её составе в 1974—1976 годах 44 матча.

Примечания

Волейболисты Италии
Игроки мужской сборной Италии по волейболу
Волейболисты на летних Олимпийских играх 1976 года

redpajama_set_name: RedPajamaWikipedia


text:
EXODUS FROM TAX-HELL STATES MAY INTENSIFY
By James Murphy - thenewamerican.com
High-tax states such as New York and California can expect more high-income residents to flee to lower tax states such as Texas or Florida, according to some experts. Punitive state and local taxes and changes to existing tax laws, most notably the new cap on deductions for state and local taxes - the so-called SALT deductions - are forcing residents of high-tax states to rethink where they wish to live.
The new $10,000 dollar cap on SALT deductions, a part of the Tax Cuts and Jobs Act signed by President Trump in December of 2017, will probably be a huge reason for the flight from tax hells. It's already having an impact on some tax returns.
And state workarounds that allowed taxpayers to make charitable donations to established state funds in order to earn credits have also been quashed by the Treasury Department. So tax loopholes are disappearing now as well. New York Governor Andrew Cuomo called the Treasury Department's actions "diabolical." "It took a few months for taxpayers to realize the dollar implications - until they actually filed their tax returns this year," Alan Goldenberg of accounting firm Friedman LLP told Fox Business. "It quantified the impact of the loss of the SALT deduction when people saw it in front of their eyes on their tax return." Goldenberg has already seen some clients relocate to more tax-friendly states. Typically, these are people with more than one home, whose profession does not require them to live in a certain location.
So the cap on SALT deductions represents a de-facto tax increase for high earners in states such as New York and California. And states such as Texas, Florida, and Nevada - none of which have a state income tax - will likely see an influx of new, high-earning residents.
Economists Arthur Laffer and Stephen Moore have estimated that in the next three years, some 800,000 over-burdened taxpayers will leave New York and California. And it won't only be California and New York, but other tax hells, such as Connecticut, New Jersey, and Minnesota, will see high-income residents move to spots more tax friendly.
It's not only individuals looking to move either. Businesses that are not location-specific are also looking to escape burdensome state income taxes. "In years to come, millions of people, thousands of businesses and tens of billions of dollars of net income will flee high-tax blue states for low-tax red states," Laffer and Moore wrote in an op-ed for the Wall Street Journal.
While acknowledging that the exodus has been underway for some time now, Laffer and Moore believe that the cap on SALT deductions is going to intensify the money migration.
According to Laffer and Moore, residents of California will see an increase in the effective income-rate [the income-tax rate that people actually pay] has risen from 8.5 percent to 13 percent. Wealthy New York City dwellers have seen their effective rate climb from 7.7 percent to 12.7 percent. Other states such as Connecticut and New Jersey have seen similar hikes. Those earning $10 million or more may see tax increases of 50 percent or more.
Consider the case of Connecticut. After tax hikes signed by Governor Dan Malloy took effect, the state saw many of its wealthiest residents including Thomas Peterffy (worth $20 billion), C. Dean Metropoulos (worth $2 billion), Paul Tudor (worth $4 billion) and Edward Lampert (worth $3 billion) flee to Florida where there is no state income tax.
Generally, people understand paying income tax. They may not like it, but they understand it. But as New York, California, and other high-tax states are finding out, there is a limit to which people and businesses can be pushed. When that limit is reached, people will go to states where they and their businesses are welcomed, rather than punished. By punishing their highest earners with absurdly high tax rates, these high tax states are shooting themselves in the foot.


text:
from oslo.config import cfg
from stevedore import extension

from ceilometer.event import converter as event_converter
from ceilometer.openstack.common import context
from ceilometer.openstack.common.gettextutils import _  # noqa
from ceilometer.openstack.common import log
from ceilometer.openstack.common.rpc import service as rpc_service
from ceilometer import pipeline
from ceilometer import service
from ceilometer.storage import models

LOG = log.getLogger(__name__)

OPTS = [
    cfg.BoolOpt('ack_on_event_error',
                default=True,
                deprecated_group='collector',
                help='Acknowledge message when event persistence fails.'),
    cfg.BoolOpt('store_events',
                deprecated_group='collector',
                default=False,
                help='Save event details.'),
]

cfg.CONF.register_opts(OPTS, group="notification")

class UnableToSaveEventException(Exception):
    """Thrown when we want to requeue an event.

    Any exception is fine, but this one should make debugging
    a little easier.
    """

class NotificationService(service.DispatchedService, rpc_service.Service):

    NOTIFICATION_NAMESPACE = 'ceilometer.notification'

    def start(self):
        super(NotificationService, self).start()
        # Add a dummy thread to have wait() working
        self.tg.add_timer(604800, lambda: None)

    def initialize_service_hook(self, service):
        '''Consumers must be declared before consume_thread start.'''
        self.pipeline_manager = pipeline.setup_pipeline()

        LOG.debug(_('Loading event definitions'))
        self.event_converter = event_converter.setup_events(
            extension.ExtensionManager(
                namespace='ceilometer.event.trait_plugin'))

        self.notification_manager = \
            extension.ExtensionManager(
                namespace=self.NOTIFICATION_NAMESPACE,
                invoke_on_load=True,
            )

        if not list(self.notification_manager):
            LOG.warning(_('Failed to load any notification handlers for %s'),
                        self.NOTIFICATION_NAMESPACE)
        self.notification_manager.map(self._setup_subscription)

    def _setup_subscription(self, ext, *args, **kwds):
        """Connect to message bus to get notifications

        Configure the RPC connection to listen for messages on the
        right exchanges and topics so we receive all of the
        notifications.

        Use a connection pool so that multiple notification agent instances
        can run in parallel to share load and without competing with each
        other for incoming messages.

        """
        handler = ext.obj
        ack_on_error = cfg.CONF.notification.ack_on_event_error
        LOG.debug(_('Event types from %(name)s: %(type)s'
                    ' (ack_on_error=%(error)s)') %
                  {'name': ext.name,
                   'type': ', '.join(handler.event_types),
                   'error': ack_on_error})

        for exchange_topic in handler.get_exchange_topics(cfg.CONF):
            for topic in exchange_topic.topics:
                try:
                    self.conn.join_consumer_pool(
                        callback=self.process_notification,
                        pool_name=topic,
                        topic=topic,
                        exchange_name=exchange_topic.exchange,
                        ack_on_error=ack_on_error)
                except Exception:
                    LOG.exception(_('Could not join consumer pool'
                                    ' %(topic)s/%(exchange)s') %
                                  {'topic': topic,
                                   'exchange': exchange_topic.exchange})

    def process_notification(self, notification):
        """RPC endpoint for notification messages

        When another service sends a notification over the message
        bus, this method receives it. See _setup_subscription().

        """
        LOG.debug(_('notification %r'), notification.get('event_type'))
        self.notification_manager.map(self._process_notification_for_ext,
                                      notification=notification)

        if cfg.CONF.notification.store_events:
            self._message_to_event(notification)

    def _message_to_event(self, body):
        """Convert message to Ceilometer Event.

        NOTE: the rpc layer currently rips out the notification
        delivery_info, which is critical to determining the
        source of the notification. This will have to get added back later.
        """
        event = self.event_converter.to_event(body)

        if event is not None:
            LOG.debug(_('Saving event "%s"'), event.event_type)
            problem_events = []
            for dispatcher in self.dispatcher_manager:
                problem_events.extend(dispatcher.obj.record_events(event))
            if models.Event.UNKNOWN_PROBLEM in [x[0] for x in problem_events]:
                # Don't ack the message, raise to requeue it
                # if ack_on_error = False
                raise UnableToSaveEventException()

    def _process_notification_for_ext(self, ext, notification):
        """Wrapper for calling pipelines when a notification arrives

        When a message is received by process_notification(), it calls
        this method with each notification plugin to allow all the
        plugins process the notification.

        """
        with self.pipeline_manager.publisher(context.get_admin_context()) as p:
            # FIXME(dhellmann): Spawn green thread?
            p(list(ext.obj.to_samples(notification)))


Rozerem (generic name: ramelteon) has a different mechanism of action to conventional insomnia treatments. It acts on melatonin receptors to induce a state close to physiologically natural sleep.
Through this integration, Takeda reinforced its marketing and development functions in the U.S., as well as further promoted efficiencies throughout its business operations. In agreement with Abbott Laboratories, TAP became a wholly-owned subsidiary of Takeda and was merged into Takeda Pharmaceuticals North America, Inc. (TPNA), and subsequently TAP's development function was integrated into Takeda Global Research & Development Center Inc. (TGRD).
Azilva (generic name: azilsartan) is an angiotensin II receptor blocker (ARB).
This treatment for relapsed or refractory Hodgkin lymphoma and systemic anaplastic large cell lymphoma was in-licensed from Seattle Genetics, Inc and launched by Takeda in the EU in 2012 and Japan in 2014. For patients suffering from these rare conditions, this prescription drug will provide another treatment option.
Entyvio is a product that offers a treatment option to patients with inflammatory bowel disease who have failed to respond to treatment with existing products. Entyvio was launched by Takeda in both the EU and the US in June 2014.


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VTara's Smart Cities initiative is an urban development vision to integrate information and communication technology (ICT) and Internet of things (IoT) technology in a secure fashion to manage a city's assets. These assets include local departments' information systems, schools, libraries, transportation systems, hospitals, power plants, water supply networks, waste management, law enforcement, and other community services. A smart city is promoted to use urban informatics and technology to improve the efficiency of services. ICT allows city officials to interact directly with the community and the city infrastructure and to monitor what is happening in the city, how the city is evolving, and how to enable a better quality of life. Through the use of sensors integrated with real-time monitoring systems, data are collected from citizens and devices – then processed and analyzed. The information and knowledge gathered are keys to tackling inefficiency.


USA Today writes "Wall Street debates prospect of bond bubble"
USA Today writes "Wall Street debates prospect of bond bubble"
USA Today writes "Wall Street debates prospect of bond bubble". It asks, "Is a bubble brewing in the normally sedate U.S. government bond market? That's the big debate raging on Wall Street. Heavy buying of 10-year Treasury notes by investors in search of a safe place to park cash, as well as higher yields than available on certificates of deposit, is pushing prices of government-issued debt sharply higher -- and knocking yields down to levels last seen 17 months ago in the depths of the financial crisis. In early April, the 10-year note yielded nearly 4%. On Friday, it was 2.62%, and last week, it hit its lowest yield since March 2009. Its all-time low yield was 2.06% in December 2008, three months after the collapse of Lehman Bros. nearly sparked a global financial meltdown. Those warning of a bubble say the infatuation with U.S. Treasuries -- long considered one of the safest investments in turbulent times -- may be morphing into a fatal attraction." See also, Bloomberg's "Bond Funds Gain Cash Like Stocks in Dot-Com Era: Credit Markets".


text:
The Gary Null Show - Birgitta Jonsdottir - 09/28/12
Update on the lawsuit against the obama administration over the National Defense Authorization Act.
Birgitta Jonsdottir is a member of Iceland's Parliament representing the progressive Movement pary, formerly known as the Citizen's Movement, which is co-founded. She serves on the Parliamentary Environmental and Foreign Affairs committees. The Movement's platform is to make Iceland an international model for free press and to promote sustainability of her nation's ecology and environment.
Birgitta is also an accomplished poet, artist, writer and activist, involved in a variety of international organizations including Poets Against the War, Friends of Tibet, in particular serving as a spokesperson for Wikileaks.
Birgitta's sponsorship and support of Wikileaks was instrumental in making the notorious video of the US airstrike on civilians in Afghanistan – known as the Collateral Murder video -- public. Subsequently in the Department of Justices witch hunts for Wikileak supporters, she herself has been a victim of attempted personal information hacking by the DofJ.
The Gary Null Show - Economic Climate - 09/27/12
Illegal drugs, governments, banks, America's economic climate
Catherine Austin Fitts is the president of Solari Inc and the publisher of the Solari Report, which provides investment consultation for shifting wealth away from financial institutions without acting on our best interests. Earlier, Catherine served as a managing director and a member of the board of directors for the Wall Street investment bank Dillon Read, and was the Assistant Secretary of Housing and Federal Housing Commissioner at the US Department of Housing and Urban Development during the first Bush administration. After leaving the Bush Administration, Catherine founded The Hamilton Securities Group, Inc., an investment bank and financial software developer named after the first U.S. Secretary of Treasury, Alexander Hamilton. In 1996, she and her successful company became targets of a vicious, longlasting "qui tam lawsuit", that resulted in the closing of Hamilton Securities. Fitts was ultimately successful in Court of Claims litigation asserting that the government had no right to withhold monies owed to Hamilton.
To date, she has designed and closed over $25 billion worth of transactions and investments and led investment strategies for over $300 billion in assets and liabilities.
Her website is www.Solari.com
The Gary Null Show - Drone Warfare - 09/26/12
The US' Drone Warfare and killing by remote control
Medea Benjamin is a cofounder of the anti-war feminist organization Codepink and a co-founder of the international human rights organization Global Exchange. For the past 20 years she has been an advocate for social justice. New York Newsday described Medea as "one of America's most committed -- and most effective -- fighters for human rights" and the Los Angeles Times called her "one of the high profile leaders of the peace movement." In 2005 she was among exemplary women nominated to receive a collective Nobel Peace Prize for their efforts to promote peace. She has been at the forefront of protesting the war efforts of Bush and Obama and her activities in the Gaza Freedom March and flotilla, and her being arrested in Pakistan for supporting silenced lawyers seeking human rights policies. In the past she has worked as an economist and nutritionist for the United Nations and World Health Organization. She has diligently fought the World Trade Organization and was responsible for bringing attention to Nike's and an additional 27 US clothing retailers for capitalizing on sweatshop labor in developing countries. She is the author of the recent book: "Drone Warfare: Killing by Remote Control" which goes into detail about this stealth weaponry, and its role in shaping US military foreign policies in many nations around the world.
Dr. Jack Rasmus is a professor of political economics at St. Mary's College and Santa Clara University in California. Prior to teaching, he was an economic analyst for several global corporations and an organizer, negotiator and business representative for several labor unions. At one time he was elected at the National First Vice President of the National Writers Union.
In addition to his economic profession, Dr. Rasmus is a playwright and author of fictional works dealing with social and labor struggles, and the owner fo Kyklos Productions. Besides his articles for progressive news and commentary sources, he is the author of several books, including "Epic Recession and Global Financial Crisis" which describes the origins and repercussions of increasing financial instability in America.
www.JackRasmus.com
The Gary Null Show - Neuro-Nutrition - 09/25/12
Neuro-nutrition and utilizing the fundamental cellular functions to advance healing from serious illnesses Dr. Yann Rougier is a medical doctor in France who has devoted over 30 years practicing medicine while researching the intersection of mind, body, nutrition, and the immune system, particularly as it applies to cancer and other degenerative diseases. He is a founding member of the Institute for Applied Neuronutrition and Neurosciences in Paris France. Dr. Rougier has created a basic program known as Delta Medicine for patients to practice, alongside either conventional or natural alternative therapies, that is based upon the fundamental cellular functions in our bodies: breathing, nutrition, waste elimination, communication with other cells and creation and expression.
He is the author of "Delta Medicine: Natural Therapies for the Five Functions of Cellular Health" for treating cancer and other degenerative diseases. He visiting our studios now on his trip to the US.
The Gary Null Show - Wishful Thinking - 09/24/12
America's epidemic of "wishful thinking" and hope in technology saving us – what this means for the fate of the nation
James Howard Kunstler is an award winning author of both fiction and non-fiction works. His books focus on the degradation of American society as well as the causes of peak oil, economic crisis, and the degeneration of intellectual integrity that we read about in the daily news. Jim's writings focus on the challenges of American urban and suburban culture, including climate change, that may be leading to "converging catastrophes in the 21st Century" His book "The Long Emergency", directly dealing with these issues, has been considered prophetic by many.
His novel, "World Made by Hand" was selected as a top five fiction pick in 2008 by National Public Radio's "All Things Considered" – which portrays American rural life after a global peak oil crisis, economic collapse, war and the rise of mythological, radical religion.
His most recent book is "Too Much Magic: Wishful Thinking, Technology and the Fate of the Nation
The Gary Null Show - Dr. Peter Breggin - 09/21/12
Psychiatric Drug Withdrawal – strategies and dangers
Dr. Peter Breggin has been called the "conscience of psychiatry" during his outstanding career to reform the mental health field. Dr. Breggin is a Harvard trained psychiatrist and a former consultant for the National Institutes of Mental Health. He is one of the harshest critics of current conventional psychotherapeutic approaches in treating mental disorders in both adults and children, particularly the epidemic use of psychoactive drugs. Along with his wife, he is the founder of the Center for the Study of Empathic Therapy, a non profit organization providing scientific-based information on dangers and adverse effects of psychiatric drugs.
Dr. Breggin has written many important books. His most recent is "Psychiatric Drug Withdrawal: A Guide for Prescribers, Therapists, Patients and the Families" which gives a comprehensive, lay person review of the strategies, stages and symptoms of drug withdrawal.
The Gary Null Show - Opposing Arguments - 09/20/12
Senate committee meeting to present arguments against limiting vaccine exemption in NJ
Louise Habakus is the co-founder and Director of theCenter for Personal Rights – a non profile advocacy organization dedicated to the protection of vaccination choice as an essential human and civil right – and sits on the Steering Committee of the Coalition for Vaccine Safety. Before becoming a certified health practitioner in Integrative Nutrition, Louise was a former managing director of Putnam Investments and a corporate VP for Prudential Financial. She has two vaccine injured children which led to her commitment and advocacy for vaccine safety and freedom for vaccine chioice.
Louise is the co-author with NYU Law professor Mary Holland of the recently revised "Vaccine Epidemic: How Corporate Greed, Biased Science and Coercive Government Threaten Our Human Rights, Our Health and Our Children."
The Gary Null Show WPFW - Dr. David Lewis - 09/19/12
The case against medical/corporate/political science for scientific misconduct regarding the MMR vaccine – exonerating Drs Walker-Smith and Wakefield.. and further corruption in the CDC and FDA
Dr. David Lewis is an internationally recognized research microbiologist and a former senior research microbiologist with the U.S. Environmental Protection Agency. He is the only EPA scientist to have published first-authored research articles in Nature, Lancet and Nature Medicine. Among his better known scientific discoveries is the use of DNA fingerprinting to study effects of climate change on the breakdown of pesticides by bacteria, the standardization of heat sterilization of dental equipment worldwide, and the dangers of sewage sludge farming that led to the EPA to discontinue its use. It was this latter research that was leading to death related incidents of sewage agriculture that led to his removal a the agency and his subsequent whistleblowing. He is now a senior science advisor for the National Whistleblowers Center in Washington DC and a member of its Board and focusing on institutional misconduct and corruption the federal and private health industry.
The Gary Null Show - Omid Safi - 09/19/12
The Gary Null Show WPFW - Sugar Smackdown - 09/18/12
Longer exercise provides added benefits to children
Sugar and its relationship to Alzheimer's and dementia


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Mega Car Removals is one of the leading Car Removal Companies in Penrith and Sydney's. We remove all types of vehicles – no matter what condition they're in.
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Used car dealers will often not buy a damaged car as it is hard to resell them. What do you do with your vehicle if you have damaged it? You sell it to a Cash for Car Company like Mega Car Removals.
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If your four-wheelers has had its best days and if it's time to put it to pasture, we'll be happy to do the job for you. Every year, we buy thousands of cars from Penrith and Sydney's, we recycle whatever parts we can and then dispose off the old cars in thoughtful, eco friendly ways.
Whether your car is a Mazda or a Beetle, a Van, Ute or Jeep – we'll take it.
The condition of your vehicle doesn't matter to us as we'll recycle the parts and metal. It's what Car Removalists like us do for a living.
If you're a corporate or Government organisation, you may have a whole fleet of cars you may need to get rid of. Sure, auctions are one way to do that – they take time and patience, however.
They can delay the placing of your order for your new fleet of Holden Commodores or Ford Falcons or another brand you may have planned.
What do you do in this case? Well, do consider selling to us at Mega Car Removal. We understand the process of sale for Government or Corporate Vehicles.
Whether by tender or direct sale, we are happy to get involved in the process and take the cars off your hands so you can place your order for new cars faster!
That's right – when it comes to money, we don't muck around. We know how a set of crisp bank notes feel in your hands, so we pay our clients cash the moment the purchase is complete.
Do note – due to recent laws passed in New South Wales, all cash payments made by Car Removal Companies in Penrith or other parts of the state must be made by Direct Bank Transfer or Cheque.
But you don't have to worry about the money clearing- as are licensed Cash for Car Removals Dealer so we are compliant with all rules regarding the purchase and sale of vehicles in New South Wales.
At Mega Car Removal, we are punctual and reliable. We arrive at the time we say we will. We also arrange pick-ups that are before or after hours.
That's right, fully aware that you may have a full-time job that keeps you busy – we operate our schedule according to yours. Mega Car Removal works 24 /7 X 365. We even operate on Australia Day, Christmas and Easter.
Give us a Call. We'd love to buy it off you. We pay well for vehicles and guarantee our prices are fair and free of any 'pressure sell tactics' – we know clients don't like them.
Upgrading your car and lifestyle?


text:
Tape Manipulations, Digital Deconstructions and Turntable Creations
This week's episode (#75) features our 2004 interview with Sound and Video collage artist, Steev Hise (Check it out HERE). As I continue to upload (and re-air) some of our older interviews with Some Assembly Required artists, I feel compelled to also do a little updating on the artists, as to what they've been up to since we aired the interview...
Steev has gone in a slightly different direction, though he's still working with video and he's always been very politically active. His recent film, "On The Edge: The Femicide in Ciudad Juarez" is a documentary which exposes the killings of hundreds of women in Ciudad Juárez, Mexico. The murders have been largely ignored by police and government since 1993, and the film points out a number of sociopolitical reasons for why this may be. The film is available on DVD from illegal art. Find out more, under the category of "Video Activism," HERE.
Steev has shown his work in Europe, Australia, and throughout the Americas. We had him out to perform in Minneapolis, in 2001. Checkout his website HERE and the 2007 SAR Q&A with Steev Hise HERE.
Thanks for listening,
Jon Nelson
www.some-assembly-required.net
posted by Jon Nelson at 11:07 PM
Name: Jon Nelson
Location: Minneapolis, Minnesota, United States
Jon Nelson is the host and producer of the nationally syndicated radio program Some Assembly Required. He's also a collage artist and curator. More info online: PostConsumerProductions.com
Episode 75, Some Assembly Required
DJ Qbert
Episode 213, Some Assembly Required
Hugo Keesing
Mr. Meridies
Bob Ostertag
Natasha Spencer


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Kepler-100d es uno de los tres planetas que orbitan a la estrella Kepler-100. Fue descubierta por el método de tránsito astronómico en el año 2014. Este planeta ha sido descubierto por el Telescopio espacial Kepler. Se confirmó utilizando una combinación de formación de imágenes de alta resolución y espectroscopía y espectroscopia Doppler. Este análisis deja la posibilidad del falso positivo por debajo del 1 por ciento y pone constreñimientos en el tamaño y la masa del planeta.

Véase también

 Planeta extrasolar
 Sistema planetario extrasolar

Referencias

Planetas extrasolares descubiertos en 2014
Planetas extrasolares en tránsito
Planetas extrasolares descubiertos por Kepler
Constelación de Lyra