text:
ViiV Healthcare to present key data that provides further support for the use of 2-drug regimens, including long-term efficacy, alongside new insights into living with HIV at IDWeek 2021
London, 22 September 2021 – ViiV Healthcare, the global specialist HIV company majority owned by GlaxoSmithKline plc (GSK), with Pfizer Inc. and Shionogi Limited as shareholders, today announced the presentation of 13 abstracts from its diverse portfolio of innovative pipeline medicines and licensed HIV treatments, including 2-drug and long-acting regimens, at the 2021 Infectious Disease Society of America (IDSA) IDWeek conference, being held virtually 29 September - 3 October.
Kimberly Smith, M.D., MPH, Head of Research & Development at ViiV Healthcare, said: "The breadth of data we're presenting at IDWeek 2021 illustrates our commitment to understanding and addressing the variety of evolving needs and challenges faced by people living with or affected by HIV. These new data address specific questions that providers have been asking and we believe will provide increased confidence in the long-term efficacy and high barrier to resistance of our integrase inhibitor-based, 2-drug regimens. We look forward to sharing these findings with the HIV community at IDWeek."
Key abstracts to be presented by ViiV Healthcare at IDWeek 2021:
144-week findings from the TANGO study evaluate switching to the fixed-dose combination of Dovato (dolutegravir/lamivudine) compared to the continuation of a tenofovir alafenamide (TAF) -based regimens of at least three drugs in virologically suppressed people living with HIV: The three-year findings to be presented at IDWeek 2021 will include efficacy, safety and tolerability data for dolutegravir/lamivudine and build on the growing body of evidence for this 2-drug regimen.1
48-week subgroup analysis of the STAT study investigating the safety and efficacy of dolutegravir/lamivudine for the treatment of HIV-1: Secondary analysis of treatment-naïve adults living with HIV was designed to build on previous 24-week feasibility, efficacy and safety outcomes of dolutegravir/lamivudine as a first-line regimen in a test-and-treat setting through 48 weeks. Findings to be presented at IDWeek 2021 will provide further insights into virologic outcomes among study participants by baseline viral load.2
Pregnancy and birth outcomes following maternal dolutegravir (DTG) use: The Antiretroviral Pregnancy Registry was designed to monitor for early warning signals of ARV effects on neonatal health. Findings to be presented at IDWeek 2021 will provide additional information about pregnancy outcomes among women exposed to DTG.3
Findings from the Positive Perspectives survey reported treatment outcomes and perceptions among people living with HIV following the global U=U educational campaign: The Undetectable = Untransmissible (U + U)) campaign was designed to improve the well-being of people living with HIV and recalibrate HIV-related social norms. The findings to be presented at IDWeek 2021 examine the effects of U=U on treatment outcomes and satisfaction, mental health and sexual health among people living with HIV in North America and also provide further insight into the impact of provider relationships on quality of life.4
Results analysing the impact of COVID-19 on HIV treatment and care among ongoing BRIGHTE trial participants: Rukobia (fostemsavir), in combination with other ARV therapies, was evaluated in heavily treatment-experienced adults with advanced HIV and COVID-19. Findings to be presented at IDWeek 2021 from the ongoing analysis characterise reported cases and outcomes of COVID-19 among study participants.5
Real-world findings from the retrospective study examining usage patterns among people receiving tenofovir-based therapy as pre-exposure prophylaxis (PrEP) in the US: The retrospective study was designed to identify adults newly initiated on tenofovir-based therapy as daily PrEP and monitor persistence. Findings to be presented at IDWeek 2021 will examine consistency of use on daily oral PrEP in the real-word setting in comparison to recent PrEP clinical trials.6
The full list of ViiV Healthcare data to be presented at IDWeek 2021 is outlined below:
Abstract title
High rates of virologic suppression with DTG/3TC (lamivudine) in newly diagnosed adults with HIV-1 infection and baseline viral load >500,000 c/mL: 48-week subgroup analysis of the STAT study
CP Rolle
Maternal Dolutegravir (DTG) Use, and Pregnancy and Birth Outcomes: The Antiretroviral Pregnancy Registry (APR)
V Vannappagari
Switching to DTG/3TC fixed-dose combination (FDC) is non-inferior to continuing a TAF-based regimen (TBR) in maintaining virologic suppression through 144 weeks (TANGO study)
O Osiyemi
Efficacy and tolerability of DTG+3TC in clinical practice: evidence from real world data
LA Evitt
The Impact of the COVID-19 Pandemic on Clinical Follow-up, Monitoring and Regimen Discontinuation for People Living with HIV in the US
G Pierone
Cabotegravir
Efficacy and safety of long-acting cabotegravir + rilpivirine in participants with HIV/HCV co-infection: ATLAS-2M 48-week results
R D'Amico
Indirect Treatment Comparison of 48-Week Efficacy and Safety of Cabotegravir + Rilpivirine Long-Acting every 8 weeks to Bictegravir/ Emtricitabine/ Tenofovir alafenamide in Suppressed HIV-1 Infected Persons
S Snedecor
Pregnancy Outcomes and Pharmacokinetics in Pregnant Women Living with HIV Exposed to Long-Acting Cabotegravir and Rilpivirine in Clinical Trials
P Patel
North American Phase 3/3b Experience with Long-Acting Cabotegravir and Rilpivirine: Efficacy, Safety, and Virologic Outcomes
BO Taiwo
Qualitative Patient-Participant Perspectives on Implementation of Monthly Cabotegravir and Rilpivirine Long Acting (CAB+RPV LA) Injectable in the United States (CUSTOMIZE)
C Garris
Real-World Persistency of Patients Receiving Tenofovir-Based Pre-Exposure Prophylaxis for the Prevention of HIV Infection in the US
A Oglesby
Fostemsavir
Characterization of Heavily Treatment Experienced HIV-1 Infected Clinical Trial Participants infected with SARS-CoV-2 COVID 19: Fostemsavir BRIGHTE Phase 3 Clinical Trial
S Chabria
Effects of the "Undetectable = Untransmittable" ("U=U") Educational Campaign on Treatment Outcomes and Perceptions among People Living with HIV in North America
F Spinelli
Important Safety Information for Dovato (50mg dolutegravir/300mg lamivudine) Tablets
DOVATO is indicated as a complete regimen to treat HIV-1 infection in adults with no antiretroviral (ARV) treatment history or to replace the current ARV regimen in those who are virologically suppressed (HIV-1 RNA <50 copies/mL) on a stable ARV regimen with no history of treatment failure and no known resistance to any component of DOVATO.
BOXED WARNING: PATIENTS CO-INFECTED WITH HEPATITIS B VIRUS (HBV) AND HIV-1: EMERGENCE OF LAMIVUDINE-RESISTANT HBV AND EXACERBATIONS OF HBV
All patients with HIV-1 should be tested for the presence of HBV prior to or when initiating DOVATO. Emergence of lamivudine-resistant HBV variants associated with lamivudine-containing antiretroviral regimens has been reported. If DOVATO is used in patients co-infected with HIV-1 and HBV, additional treatment should be considered for appropriate treatment of chronic HBV; otherwise, consider an alternative regimen.
Severe acute exacerbations of HBV have been reported in patients who are co-infected with HIV-1 and HBV and have discontinued lamivudine, a component of DOVATO. Closely monitor hepatic function in these patients and, if appropriate, initiate anti-HBV treatment.
Do not use DOVATO in patients with previous hypersensitivity reaction to dolutegravir or lamivudine
Do not use DOVATO in patients receiving dofetilide
Hypersensitivity Reactions:
Hypersensitivity reactions have been reported with dolutegravir and were characterized by rash, constitutional findings, and sometimes organ dysfunction, including liver injury
Discontinue DOVATO immediately if signs or symptoms of severe skin or hypersensitivity reactions develop, as a delay in stopping treatment may result in a life-threatening reaction. Clinical status, including liver aminotransferases, should be monitored and appropriate therapy initiated
Hepatotoxicity:
Hepatic adverse events have been reported, including cases of hepatic toxicity (elevated serum liver biochemistries, hepatitis, and acute liver failure), in patients receiving a dolutegravir-containing regimen without pre-existing hepatic disease or other identifiable risk factors
Patients with underlying hepatitis B or C or marked elevations in transaminases prior to treatment may be at increased risk for worsening or development of transaminase elevations with use of DOVATO. In some cases, the elevations in transaminases were consistent with immune reconstitution syndrome or hepatitis B reactivation, particularly in the setting where anti-hepatitis therapy was withdrawn
Monitoring for hepatotoxicity is recommended
Embryo Fetal Toxicity:
Assess the risks and benefits of DOVATO and discuss with the patient to determine if an alternative treatment should be considered at the time of conception through the first trimester of pregnancy due to the risk of neural tube defects
Pregnancy testing is recommended before initiation of DOVATO. Individuals of childbearing potential should be counselled on the consistent use of effective contraception
Lactic Acidosis and Severe Hepatomegaly with Steatosis:
Fatal cases have been reported with the use of nucleoside analogues, including lamivudine. Discontinue DOVATO if clinical or laboratory findings suggestive of lactic acidosis or pronounced hepatotoxicity develop, including hepatomegaly and steatosis in the absence of marked transaminase elevations.
Adverse Reactions or Loss of Virologic Response Due to Drug Interactions with concomitant use of DOVATO and other drugs may occur (see Contraindications and Drug interactions).
Immune Reconstitution Syndrome, including the occurrence of autoimmune disorders with variable time to onset, has been reported with the use of DOVATO.
The most common adverse reactions (incidence ≥2%, all grades) with DOVATO were headache (3%), nausea (2%), diarrhoea (2%), insomnia (2%), fatigue (2%), and anxiety (2%).
Consult full Prescribing Information for DOVATO for more information on potentially significant drug interactions
DOVATO is a complete regimen. Coadministration with other antiretroviral medications for the treatment of HIV-1 infection is not recommended
Drugs that induce or inhibit CYP3A or UGT1A1 may affect the plasma concentrations of dolutegravir
Administer DOVATO 2 hours before or 6 hours after taking polyvalent cation-containing antacids or laxatives, sucralfate, oral supplements containing iron or calcium, or buffered medications. Alternatively, DOVATO and supplements containing calcium or iron can be taken with food
Use in specific populations
Pregnancy: There are insufficient human data on the use of DOVATO during pregnancy to definitively assess a drug-associated risk for birth defects and miscarriage. An Antiretroviral Pregnancy Registry has been established. Advise individuals of childbearing potential of the potential risk of neural tube defects. Assess the risks and benefits of DOVATO and discuss with the patient to determine if an alternative treatment should be considered at the time of conception through the first trimester of pregnancy or if pregnancy is confirmed in the first trimester
Lactation: Breastfeeding is not recommended due to the potential for HIV-1 transmission, developing viral resistance in HIV-positive infants, and adverse reactions in a breastfed infant
Females and Males of Reproductive Potential: Pregnancy testing is recommended before initiation of DOVATO. Counsel individuals of childbearing potential taking DOVATO on the consistent use of effective contraception
Renal Impairment: DOVATO is not recommended for patients with creatinine clearance <30 mL/min. Patients with a sustained creatinine clearance between 30 and 49 mL/min should be monitored for hematologic toxicities, which may require a dosage adjustment of lamivudine as an individual component
Hepatic Impairment: DOVATO is not recommended in patients with severe hepatic impairment (Child-Pugh Score C)
Please refer to the full European Summary of Product Characteristics for Dovato for full prescribing information, including contraindications, special warnings and precautions for use. For the US, please refer to the US Prescribing Information, including Boxed Warning.
Important Safety Information for Cabenuva (cabotegravir 200 mg/mL; rilpivirine 300 mg/mL) extended release injectable suspensions
Cabenuva is indicated as a complete regimen for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults to replace the current antiretroviral regimen in those who are virologically suppressed (HIV-1 RNA less than 50 copies per mL) on a stable antiretroviral regimen with no history of treatment failure and with no known or suspected resistance to either cabotegravir or rilpivirine.
Do not use Cabenuva in patients with previous hypersensitivity reaction to cabotegravir or rilpivirine.
Do not use Cabenuva in patients receiving carbamazepine, oxcarbazepine, phenobarbital, phenytoin, rifabutin, rifampin, rifapentine, systemic dexamethasone (>1 dose), and St John's wort.
Hypersensitivity reactions, including cases of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), have been reported during postmarketing experience with rilpivirine-containing regimens. While some skin reactions were accompanied by constitutional symptoms such as fever, other skin reactions were associated with organ dysfunctions, including elevations in hepatic serum biochemistries.
Serious or severe hypersensitivity reactions have been reported in association with other integrase inhibitors and could occur with Cabenuva.
Discontinue Cabenuva immediately if signs or symptoms of hypersensitivity reactions develop. Clinical status, including liver transaminases, should be monitored and appropriate therapy initiated. Prescribe the oral lead-in prior to administration of Cabenuva to help identify patients who may be at risk of a hypersensitivity reaction.
Post-Injection Reactions:
Serious post-injection reactions (reported in less than 1% of subjects) were reported within minutes after the injection of rilpivirine, including dyspnea, agitation, abdominal cramping, flushing, sweating, oral numbness, and changes in blood pressure. These events may have been associated with inadvertent (partial) intravenous administration and began to resolve within a few minutes after the injection.
Carefully follow the Instructions for Use when preparing and administering Cabenuva to avoid accidental intravenous administration. Observe patients briefly (approximately 10 minutes) after the injection. If a post-injection reaction occurs, monitor and treat as clinically indicated.
Hepatotoxicity has been reported in patients receiving cabotegravir or rilpivirine with or without known pre-existing hepatic disease or identifiable risk factors.
Patients with underlying liver disease or marked elevations in transaminases prior to treatment may be at increased risk for worsening or development of transaminase elevations.
Monitoring of liver chemistries is recommended and treatment with Cabenuva should be discontinued if hepatotoxicity is suspected.
Depressive Disorders:
Depressive disorders (including depressed mood, depression, major depression, mood altered, mood swings, dysphoria, negative thoughts, suicidal ideation or attempt) have been reported with Cabenuva or the individual products.
Promptly evaluate patients with depressive symptoms.
Risk of Adverse Reactions or Loss of Virologic Response Due to Drug Interactions:
The concomitant use of Cabenuva and other drugs may result in known or potentially significant drug interactions (see Contraindications and Drug Interactions).
Rilpivirine doses 3 and 12 times higher than the recommended oral dosage can prolong the QTc interval. Cabenuva should be used with caution in combination with drugs with a known risk of Torsade de Pointes.
Long-Acting Properties and Potential Associated Risks with Cabenuva:
Residual concentrations of cabotegravir and rilpivirine may remain in the systemic circulation of patients for prolonged periods (up to 12 months or longer). Select appropriate patients who agree to the required monthly injection dosing schedule because non-adherence to monthly injections or missed doses could lead to loss of virologic response and development of resistance.
To minimize the potential risk of developing viral resistance, it is essential to initiate an alternative, fully suppressive antiretroviral regimen no later than 1 month after the final injection doses of Cabenuva. If virologic failure is suspected, switch the patient to an alternative regimen as soon as possible.
The most common adverse reactions (incidence ≥2%, all grades) with Cabenuva were injection site reactions, pyrexia, fatigue, headache, musculoskeletal pain, nausea, sleep disorders, dizziness, and rash.
Refer to the applicable full Prescribing Information for important drug interactions with Cabenuva, Vocabria, or rilpivirine.
Because Cabenuva is a complete regimen, coadministration with other antiretroviral medications for the treatment of HIV-1 infection is not recommended.
Drugs that are strong inducers of UGT1A1 or 1A9 are expected to decrease the plasma concentrations of cabotegravir. Drugs that induce or inhibit CYP3A may affect the plasma concentrations of rilpivirine.
Cabenuva should be used with caution in combination with drugs with a known risk of Torsade de Pointes.
Pregnancy: There are insufficient human data on the use of Cabenuva during pregnancy to adequately assess a drug-associated risk for birth defects and miscarriage. Discuss the benefit-risk of using Cabenuva during pregnancy and conception and consider that cabotegravir and rilpivirine are detected in systemic circulation for up to 12 months or longer after discontinuing injections of Cabenuva. An Antiretroviral Pregnancy Registry has been established.
Lactation: The CDC recommends that HIV 1−infected mothers in the United States not breastfeed their infants to avoid risking postnatal transmission of HIV-1 infection. Breastfeeding is also not recommended due to the potential for developing viral resistance in HIV-positive infants, adverse reactions in a breastfed infant, and detectable cabotegravir and rilpivirine concentrations in systemic circulation for up to 12 months or longer after discontinuing injections of Cabenuva.
Please see full Prescribing Information for Cabenuva.
Important Safety Information for Rukobia (fostemsavir), 600 mg extended-release tablets
RUKOBIA, a human immunodeficiency virus type 1 (HIV-1) gp120-directed attachment inhibitor, in combination with other antiretroviral(s), is indicated for the treatment of HIV-1 infection in heavily treatment-experienced adults with multidrug-resistant HIV-1 infection failing their current antiretroviral regimen due to resistance, intolerance, or safety considerations.
Do not use in patients with previous hypersensitivity to fostemsavir or any of the components of RUKOBIA.
Do not use RUKOBIA in patients receiving strong cytochrome P450 (CYP)3A inducers, including but not limited to enzalutamide, carbamazepine, phenytoin, rifampin, mitotane, and St John's wort (Hypericum perforatum).
Immune Reconstitution Syndrome, including the occurrence of autoimmune disorders with variable time to onset, has been reported with the use of RUKOBIA.
QTc Prolongation with Higher than Recommended Dosages: RUKOBIA at 2,400 mg twice daily has been shown to significantly prolong the QTc interval of the electrocardiogram. Use RUKOBIA with caution in patients with a history of QTc interval prolongation or in patients with relevant pre-existing cardiac disease or who are taking drugs with a known risk of Torsade de Pointes. Elderly patients may be more susceptible to drug-induced QT interval prolongation.
Elevations in Hepatic Transaminases in Patients with Hepatitis B or C Virus Co-infection:
Monitoring of liver chemistries is recommended in patients with hepatitis B and/or C co-infection.
Diligence should be applied in initiating or maintaining effective hepatitis B therapy when starting RUKOBIA in patients co-infected with hepatitis B.
Adverse Reactions or Loss of Virologic Response Due to Drug Interactions with concomitant use of RUKOBIA and other drugs may occur (see Contraindications and Drug Interactions).
The most common adverse reaction (all grades, randomized cohort) observed in ≥5% of subjects was nausea (10%).
81% of adverse reactions reported with RUKOBIA were mild or moderate in severity.
See the full Prescribing Information for RUKOBIA for a complete list of significant drug interactions.
Temsavir may increase plasma concentrations of grazoprevir and voxilaprevir. Use an alternative hepatitis C virus regimen if possible.
Use the lowest possible starting dose for statins and monitor for statin-associated adverse events.
Patients receiving RUKOBIA should not take doses of estrogen-based therapies, including oral contraceptives, that contain more than 30 mcg/day of ethinyl estradiol. Caution is advised particularly in patients with additional risk factors for thromboembolic events.
Pregnancy: There are insufficient human data on the use of RUKOBIA during pregnancy to definitively assess a drug-associated risk for birth defects and miscarriage. An Antiretroviral Pregnancy Registry has been established.
Lactation: Breastfeeding is not recommended due to the potential for HIV-1 transmission, developing viral resistance, and adverse reactions in a breastfed infant.
Please see full Prescribing Information for Rukobia
ViiV Healthcare is a global specialist HIV company established in November 2009 by GlaxoSmithKline (LSE: GSK) and Pfizer (NYSE: PFE) dedicated to delivering advances in treatment and care for people living with HIV and for people who are at risk of becoming infected with HIV. Shionogi joined as a shareholder in October 2012. The company's aims are to take a deeper and broader interest in HIV/AIDS than any company has done before and take a new approach to deliver effective and innovative medicines for HIV treatment and prevention, as well as support communities affected by HIV.
For more information on the company, its management, portfolio, pipeline, and commitment, please visit www.viivhealthcare.com.
GSK is a science-led global healthcare company. For further information please visit www.gsk.com/about-us.
Catherine Hartley
Benjamyn Tan
+1 919 491 0831 (North Carolina)
+44 (0) 7909 2403 (London)
+44 (0) 7780 494 823 (London)
GSK enquiries:
Tim Foley
Kathleen Quinn
+44 (0) 20 8047 5502 (London)
+1 804 217 8147 (Philadelphia)
+1 202 603 5003 (Washington DC)
Analyst/Investor enquiries:
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Frannie DeFranco
+44 (0) 7990 339653 (London)
GSK cautions investors that any forward-looking statements or projections made by GSK, including those made in this announcement, are subject to risks and uncertainties that may cause actual results to differ materially from those projected. Such factors include, but are not limited to, those described in the Company's Annual Report on Form 20-F for 2020, GSK's Q1 Results and any impacts of the COVID-19 pandemic.
Registered in England & Wales:
GSK PLC ViiV Healthcare Limited
No. 3888792 No. 06876960
Brentford, Middlesex
Osiyemi O, Ajana F, Bisshop F, et al. Switching to DTG/3TC Fixed-Dose Combination (FDC) Is Non-inferior to Continuing a TAF-Based Regimen (TBR) in Maintaining Virologic Suppression through 144 Weeks (TANGO Study). Presented at IDWeek 2021.
Rolle CP, Berhe M, Singh T, et al. High Rates of Virologic Suppression with DTG/3TC in Newly Diagnosed Adults with HIV-1 Infection and Baseline Viral Load >500,000 c/mL: 48-Week Subgroup Analysis of the STAT Study. Presented at IDWeek 2021.
Vannappagari V, Albano JD, Ragone L, et al. Maternal Dolutegravir (DTG) Use, and Pregnancy and Birth Outcomes: The Antiretroviral Pregnancy Registry (APR). Presented at IDWeek 2021.
Spinelli F, Richman, B, del los Rios P, et al. Effects of the "Undetectable = Untransmittable" ("U=U") Educational Campaign on Treatment Outcomes and Perceptions among People Living with HIV in North American Countries. Presented at IDWeek 2021.
Chabria S, De Wit S, Pierce A, et al. Characterization of Heavily Treatment Experienced HIV-1 Infected Clinical Trial Participants infected with SARS-CoV-2 COVID 19: Fostemsavir BRIGHTE Phase 3 Clinical Trial. Presented at IDWeek 2021.
Ogelsby A, Germain G, Laliberté F, et al. Real-World Persistency of Patients Receiving Tenofovir-Based Pre-Exposure Prophylaxis for the Prevention of HIV Infection in the US. Presented at IDWeek 2021.
For our corporate press office, email: Melinda Stubbee
OR call +44(0)7341079531
For US-specific media enquiries, email: Audrey Abernathy


text:
Das Tapeti oder Brasilien-Waldkaninchen (Sylvilagus brasiliensis) ist eine Art der Baumwollschwanzkaninchen (Sylvilagus), die in Südamerika bis in das nördliche Argentinien beheimatet ist.

Merkmale
Das Tapeti erreicht eine Kopf-Rumpf-Länge von 38 bis 42 Zentimetern, die Schwanzlänge beträgt 20 bis 21 Millimeter und das Gewicht liegt zwischen 500 und 950 Gramm. Die Ohrlänge beträgt 50 bis 90 Millimeter, die Hinterfußlänge 77 bis 80 Millimeter. Es handelt sich damit um eine vergleichsweise kleine Art der Baumwollschwanzkaninchen. Es kommt in etwa 20 Unterarten vor und entsprechend sind die Farbmerkmale sehr variabel. Die Rückenfärbung reicht von einem hellen Grau bis zu einem fast einfarbigen Schwarz. Die Körperseiten und die Oberseite des Schwanzes sind in der Regel etwas heller als die Rückenfärbung, die Unterseite des Schwanzes meist sandbraun. Die Bauchseite ist in der Regel hellgrau oder weiß, an der Kehle befindet sich ein dunkler Kehlfleck.

Verbreitung

Das Tapeti ist in zahlreichen Unterarten über weite Teile Südamerikas von Venezuela bis in das nördliche Argentinien verbreitet. Es kommt in Waldrandgebieten sowie in angrenzenden offenen Flächen vor, wobei es auch in anthropogen gestörte Gebiete vordringt und landwirtschaftliche Flächen nutzt.

Lebensweise

Das Tapeti ist ein solitäres und nachtaktives Tier, welches im Normalfall besonders in der Abend- oder Morgendämmerung zu sehen ist. Es ist vorwiegend ein Bewohner der tropischen Wälder, meist im Bereich von Sumpfgebieten oder entlang von Flüssen, aber auch in Siedlungsnähe in Gärten und Parks, und ernährt sich vor allem von Gräsern und Laub.

Im Gegensatz zu anderen Arten bringt es nur einmal im Jahr Nachwuchs zur Welt, die Tragzeit ist mit sechs Wochen länger und die Wurfgröße mit nur zwei kleiner als die anderer Baumwollschwanzkaninchen.

Systematik
Das Tapeti wird als eigenständige Art innerhalb der Gattung der Baumwollschwanzkaninchen (Sylvilagus) eingeordnet. Die Art war bereits dem schwedischen Naturwissenschaftler Carl von Linné bekannt, der das Tapeti in seinem Systema naturae wissenschaftlich beschrieb und als Lepus brasiliensis einordnete. Ursprünglich umfasste das Taxon auch das heute als eigenständig betrachtete Mittelamerikanische Tapeti (S. gabbi) und das Dice-Baumwollschwanzkaninchen (S. dicei) und es ist möglich, dass einige der heute als Unterarten betrachteten Taxa ebenfalls eigenständige Arten sind.

Innerhalb der Art werden gemeinsam mit der Nominatform derzeit 19 Unterarten unterschieden.

Belege

Literatur
 Common Tapeti. In: S.C. Schai-Braun, K. Hackländer: Family Leporidae (Hares and Rabbits) In: Don E. Wilson, T.E. Lacher, Jr., Russell A. Mittermeier (Herausgeber): Handbook of the Mammals of the World: Lagomorphs and Rodents 1. (HMW, Band 6) Lynx Edicions, Barcelona 2016, S. 120–121. ISBN 978-84-941892-3-4.
 Louise H. Emmons, Francois Feer: Neotropical Rainforest Mammals, A Field Guide. 1997.

Weblinks

Baumwollschwanzkaninchen

redpajama_set_name: RedPajamaWikipedia


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text:
German police make arrests over massive child pornography website
June 7, 2022 by Bella Webb Leave a Comment
BERLIN, May 3 (Reuters) – German police have uncovered one of the world's largest underground websites for child pornography with more than 400,000 users and arrested four people connected to the platform, prosecutors said on Monday.
The "BOYSTOWN" platform has existed since at least June 2019 and darknet market links was only accessible via the so-called darknet market, the Frankfurt public prosecutor's office and the BKA Federal Police said in a statement.
The website has more than 400,000 users and was used for the worldwide exchange of child pornography.It enabled members to retrieve child pornography content and exchange footage with each other in chat areas as well as via voice channels.
"Among the images and video recordings shared were also recordings of the most severe sexual abuse of young children," prosecutors said.
Police arrested three main suspects, who are accused of operating and maintaining the platform, during raids on seven properties in mid-April.
The suspects are a 40-year-old man living in Paderborn in western Germany, dark market onion web darknet market a 49-year-old man from the Munich area and a 58-year-old man from northern Germany who has been living in South America for several years, darknet market links police said.
A fourth man, a 64-year-old from Hamburg, has also been arrested on suspicion of having registered as a member of the platform in July 2019 and having posted over 3,500 contributions on the site, making him one of the most active users.
Following the raids, the BOYSTOWN platform has been taken down, dark markets 2022 police said.
(Reporting by Caroline Copley; Editing by Giles Elgood)
Bella Webb

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: Cannot login to any TTYs - Wrong password I am using Ubuntu 12.10 with Unity desktop. I go to TTY1 by pressing keys CTRL + ALT + F1, where I am asked to enter username and password, which I do, but I get the message "Login incorrect". In my log file /var/log/auth.log this entry has been made:
Oct 23 13:17:45 SomeName login[3361]: FAILED LOGIN (1) on 'dev/tty1' FOR 'aUser', Authentication failure

I do not have the wrong username or password. It is the same username/password I use to log in when Unity starts.
So how come I can't log in to TTY1?

A: The most common cause of this error is simply typing your password (or username) wrong. The keymap in the console is often subtly different from the one in X.
Make sure you're typing the correct password by first typing it in the login field where you can see if it's being written as expected.
Check that you're typing your username exactly as it should be (including case), by comparing it to the output of whoami run in a terminal.

Another thing that will cause this exact same error message is if your login shell is not listed in /etc/shells. Find which shell you're using by searching for your username in /etc/passwd:
grep "dave" /etc/passwd

(replacing dave with your username) you should see something like this:
dave:x:1000:1000::/home/dave:/bin/zsh

The last field (/bin/zsh) is your shell. Let's search for it in /etc/shells:
grep "/bin/zsh" /etc/shells

We should see something like this:
/bin/zsh
/usr/bin/zsh

But if you don't, that's what the problem is. Try re-installing zsh (or whatever shell is missing from /etc/shells), and if that doesn't work, add it manually:
echo `/bin/zsh` | sudo tee /etc/shells

(we use tee because > redirection doesn't work with sudo)

A: Perhaps your keymap configuration is wrong fo the tty (which is a different setting than Xorg / Unity) and your password is wrong because of this. Try entering your password when you're prompted for your username and see if the characters turn out right; don't press enter, but delete your input (since login tries get logged and your password would be in that logfile). If something is wrong, you must set the keymap. In unity, open the terminal application and enter
sudo dpkg-reconfigure console-setup

and choose the right layout there. You might have to reboot.

A: Maybe the layout is different.Also to login in console you have to enter username wich can be different from your name in profile installation option.For example there is user profile name wich is Andrew but the user pc name can  differ.See it here
I have my profile name on russian and when i login to console i use english login name. If the problem not in this try it http://www.noobslab.com/2012/02/reset-your-forgotten-password-quickly.html

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Fleetwood's former Sea Cadets CO Derek Scrivener proudly receives his British Citizen Award
One of Fleetwood's best known characters has been presented with the British Citizen Award at a ceremony in the town.
Lt Cdr Derek Scrivener with his British Citizen Award medal. Photo: Robert Stead
Lt Cdr Derek Scrivener, the former Commanding Officer of Fleetwood Sea Cadets unit, was presented with the award at the North Euston Hotel, in front of family, some of his ex-Cadets and other invited guests.
It was a proud moment for Derek, 93, who attended the event with wife Jean.
He received his medal, which recognises exceptional work in the community, from the High Sheriff of Lancashire, Edwin Booth.
Derek and Jean Scrivener with some of the ex-Sea Cadets who nominated him for the award
Derek, of Beach Road, was commanding officer of Fleetwood Sea Cadets for 28 years until 1986, during which time the unit excelled on several fronts and was acknowledged as the best unit in the country, winning the prestigious Canada Trophy four times.
Derek said: "It's all been excellent and the people who arranged it have done a magnificent job, it was first class.
"The North Euston Hotel staff were wonderful.
"At the back of my mind I was thinking about the Cadets and their mums and dads, who really supported us all back then.
"I was particularly pleased for my wife and that our family was there with us."
The BCA presentation would usually be carried out at the Palace of Westminster, but due to Covid, it was postponed.
It meant however, that the ceremony could be held with many of Lt Cdr Scrivener's family and friends in attendance and 80 ex-Sea Cadets
Among those attending were members of Derek's family – wife Jean, sons Dave and Charles and their own families.
Dave,of Broadway, said: "Our own children were born long after their granddad was involved in Fleetwood Sea Cadets, so they never really knew what he did.
"They have loved finding out about it, hearing all the stories and seeing the photos and articles on display in the North Euston.
"People often tell me that my dad changed their lives through his work with the Sea Cadets.
"Many of them went on to enjoy careers in the Royal Navy and other services.
"So to see him presented with this award was such a proud moment for all of us."
The event was also attended by other dignitaries, including the Mayor of Wyre, Coun. Andrea Kay, the MP Lancaster and Fleetwood, Cat Smith and the chairman of the Fleetwood Civic Society, Margaret Daniels.
The BCA , also known as The People's Honours, is held bi-annually in the United Kingdom for individuals doing extraordinary work in their local community.
Derek was selected from thousands of nominations and his was one of only 25 such awards bi-annually.
He was nominated for the award by seven ex-members of the Fleetwood Sea Cadets – Paul Reynolds, John Large, David Bentley, David Morris, Steve Carr, Tony Samson and Jim Taylor.
Paul Reynolds, said: "As many people in Fleetwood will be aware, Lt Cdr Scrivener was the driving force behind Fleetwood Sea Cadets for a long time.
"The unit achieved many awards and the band were the very best in the country.
"Derek dedicated his life to serving Queen and country in the Royal Navy, and then Fleetwood Sea Cadet Corps and others, so we're all delighted to see him receive this much-deserved medal."
And Cat Smith, who backed Derek's nomination for the award with a supporting letter, said: "Derek has given many young people from this town the skills and confidence to enjoy fine careers in the maritime industry and this award really is a proud moment for the whole town."
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My Nature Blog
Peterson Moth Guides
PFG to Moths of Western North America
On Remembrance Day
Loved, and were loved, and now we lie
— Lt.-Col. John McCrae (1872 – 1918)
This poem was written in 1915 by a Canadian from Guelph, Ontario, very near my hometown and the city where I attended university. He wrote it during World War I, after witnessing the death of a friend and fellow soldier. He was apparently unsatisfied with it, and tore it out of the notebook where he had written it. The page was rescued by a fellow officer and the poem printed in Punch magazine. In 1918, a professor at the University of Georgia, who spent the war years on leave to help train YWCA workers in New York, wrote a poem of her own in response.
Oh! you who sleep in Flanders Fields,
Sleep sweet – to rise anew!
We caught the torch you threw
And holding high, we keep the Faith
With All who died.
We cherish, too, the poppy red
That grows on fields where valor led;
It seems to signal to the skies
That blood of heroes never dies,
But lends a lustre to the red
Of the flower that blooms above the dead
And now the Torch and Poppy Red
We wear in honor of our dead.
Fear not that ye have died for naught;
We'll teach the lesson that ye wrought
— Moina Michael (1869 – 1944)
It was from this response, and the last stanza in particular, that we now wear red poppies on Remembrance Day.
I learned the John McCrae poem when very young, in grade school. I'm sure we memorized the whole thing; perhaps we recited it as a class as part of an assembly. A portion of the poem has even been printed on the current Canadian $10 bills. Despite that at one time or another most of us have probably learned the whole thing, I suspect the majority of young Canadians only know the first two lines: "In Flanders' fields the poppies blow/Between the crosses, row on row". That's all I'm able to remember; I had to look up the rest. We probably don't know why we wear poppies, aside from the obvious connection to the first line in McCrae's poem. I suspect most young Canadians have never heard Moina Michael's poem; certainly I never did (or if I had, it wasn't emphasized the way McCrae's was).
At just 29, I am far too young to be able to remember either of the wars we are commemorating on Remembrance Day. Even my parents are unable to remember the wars themselves, born after the second ended, although as children of the baby boomer generation they surely felt the effects on their daily lives when young. My grandfather would sometimes share stories from his war days when he was stationed in southern Ontario monitoring radio frequencies for enemy activity (I think). The only story I can remember in any detail was of him stashing a young, barely-clothed woman under his bed when his senior officer dropped in unexpectedly during his shift.
For the most part, I understand what took place during the two world wars. I recognize that our freedom today is largely due to the sacrifices made by the soldiers in those wars. I appreciate their sacrifice, I give thanks to the deceased, and honour the fallen soldiers. I purchase a red plastic poppy to show my respect, which I pin on to my purse where it won't fall off so easily, lasting most of the year till next Remembrance Day.
But I cannot remember. The only war to have taken place within my conscious awareness has been the current one, and unfortunately, while I support the troops who are there, the war itself is not one I believe in. I can read all about the horrors of the two world wars, I can learn the poems and observe the moment of silence; I can understand and I can recognize, but I can't relate. With each generation, the connection to those wars becomes frailer. To today's youth, for my own children when I have them, the stories of the wars are little more than that: stories. The child knows what to believe, knows how to act, but they do so only because they are told to do so. Is it possible to engage a child to connect with a past they've never known?
Last year on Remembrance Day I heard a radio show by Canadian Stuart McLean, author of the Vinyl Cafe short stories (the Canadian equivalent of the US Prairie Home Companion or Lake Woebegon stories). I must have been driving somewhere for something, as I rarely have the radio on at home, and the show happened to be on. It was a Remembrance Day special, and there was one story that he told that really stuck with me, of a man who travels with his family overseas to France on a tour of a number of the sites, including Dieppe and Vimy. He brings his bagpipes with him, and offers a moving tribute to the fallen soldiers at Vimy Ridge. But the story notes that it is only after having visited the historical sites themselves that the man feels any connection to the events of the past.
The CBC shares its shows online as podcasts. You can download the Stuart McLean Remembrance Day podcast here. The whole show is worth listening to, but the story above starts at about 24:00 minutes, and is about 22 minutes long.
Author: Seabrooke
Author of Peterson Field Guide to Moths. #WriteOnCon Mastermind. Writer of action/thriller SF/F YA. Story junkie. Nature nut. Tea addict. Mother. Finding happiness in the little things. Twitter: @SeabrookeN / @SeabrookeLeckie	View all posts by Seabrooke
Author SeabrookePosted on November 11, 2009 November 12, 2009 Categories abioticTags Remembrance Day
11 thoughts on "On Remembrance Day"
Tahlia says:
I think that the fact that we have no wars to remember in two generations (and three, including our children) is due to the acts of our veterans. I think that remembering (not remembering the wars themselves, but the fact that there was a war and so many people gave up their lives for it) is even more important because we have never experienced an actual war. Although really, we have — neither World War was fought on Canadian soil.
I have so many clients who are veterans. I have a radar technician, I have a guy who actually dropped the bombs, I have several pilots. I had a German soldier who was scarred for life for having to be in the German army fighting for a cause he didn't believe was right. He had to join the army when he was just a teenager and was in it for years before becoming a POW, which he said was the best part of the war. He was forever resentful that he had to give up his youth for the war. He always said that "war belongs in the garbage".
Seabrooke says:
That's a good point, Tahlia. I think "remembrance" is a bit of a misnomer, in any case, even in a less literal sense of the word. Maybe they need to change the way it's emphasized at school, then, or at least the schools that I went to. I think for me, growing up, it didn't feel all that different from some sort of religious training, like Bible school or something. I don't think I ever really understood just what the day was all about. To me, as a kid, it was a day of poppies and crosses and one-minute silences. Maybe it would be more to the point to take the kids on a field trip that day and go to a cemetery where there are rows upon rows of crosses (even a relatively small assemblage of a hundred would seem like a huge number to a kid) and explain that each one represents someone who died for our freedom. I dunno. Death and sacrifice and suffering and conflict are all so far outside the realm of familiarity of most children.
Working with the veterans would also give you perspective, I think, especially those who were involved in the fighting. Being able to hear their firsthand stories. I don't think we ever had a veteran come to our school to speak.
barefootheart says:
Grandad was stationed at Mount Hope in Hamilton, where he was a radar operator. Radar was invented early in the 20th century, but it was during the War that the English developed it to detect planes. The term RADAR was coined in 1941 as an acronym for RAdio Detection And Ranging. This is what the Hamilton Historical Board says about Mt. Hope:
THEY SLIPPED THE SURLY BONDS OF EARTH
The British Commonwealth Air Training Plan (B.C.A.T.P.) was inaugurated in 1939 at the onset of the Second World War to provide air training for Commonwealth airmen, safely removed from active war zones. The Canadian Government sponsored this war-winning plan which produced approximately 140,000 airmen and 45,000 ground crew.
Six of the one hundred and seven Canadian B.C.A.T.P airfields were located in this part of Ontario. No. 33 Air Navigation School at Mount Hope was established in 1941 in addition to No. 10 Elementary Flying School and No. 1 Air Wireless School. Between November 1941 and December 1943, sixteen R.A.F. servicemen in the Air Navigation School died while in training here and all but two were buried in St. Paul's Glanford Anglican Church Cemetery. A service of remembrance has been held annually for these men who lie far from home. In 2000, a Remembrance Garden was planted by the congregation and dedicated to the memory of these R.A.F. members.
Hamilton Historical Board 2005
Most of the men in Grandad's squadron in England became tail gunners. One def. I found says this:
A very brave bloke who sat for hours in the rear gun turret of a WW2 bomber having the shit shot out of him by enemy fighters. It was lonely freezingly cold job with a high mortality rate.
A WW2 bomber had several defensive gun turrets, the rear one was the most vunerable to being hit by an enemy fighter's machine guns.
Small men were assigned to this because they fit the space available. Many of the young men Grandad knew died. Grandad alone was sent to Mt. Hope. The reason? He knew Morse Code. His father, a sea captain, had taught it too him years ago and they used it to "talk" around the house, so he was very good at it. Thus, he was pulled out of the group and came to Canada instead.
I had no idea about any of that. I wonder why I never asked? Maybe I assumed that Grandad didn't want to talk about it, the stereotype is that the war veterans don't want to talk about what went on during the war, that it upsets them. That was a lucky break for Grandad. I didn't realize that was how he came to Canada, either. So much we don't know about our elders, or only learn when we are young and can't appreciate or remember.
Fiddlegirl says:
I don't remember the scantily clad woman story, but I do remember him telling me he was there only because he knew Morse code, something he was quite proud of (knowing Morse code, not going to Canada). Then, as I understood, he stayed in Canada because he met Nana here.
Clearly I wasn't paying enough attention when he was sharing his stories, then! Or maybe I just have a porous memory.
By the way, pretty certain that any story about scantily clad women is apocryphal, meant to entertain grandchildren.
Two years ago our community chorus sang "In Flanders Fields" as part of our summer concert. It has a very simple and moving melody, and that, combined with the words, made it very difficult for me to sing. I finally got to where I could get through it in rehearsal, but when it came time for the concert, I lost it. I simply stood there, chin trembling, mopping my eyes and trying to keep from sobbing. I think the thing that made me lose it was seeing my dad, a Vietnam veteran, in the audience.
It sounds like that at least in Canada an effort is made to make Rememberance Day important. In the US, Veterans' Day (same day) is, for most people, just another day off, a day for sales in the shops, etc. Although, I have noticed that with our current conflict(s), more reverence is given to veterans, probably to "make up" for how the soldiers who fought in Vietnam were treated.
I don't think I've ever heard the lyrical version of the poem, Ellen, just the recited one. It's amazing how much a simple melody can be emotionally powerful.
I didn't realize that Remembrance Day wasn't given the same respect in the US. I'm a little surprised, given that the United States have a stronger and more active military than Canada does (our armed forces are smaller and more focused on peacekeeping and humanitarian aid). We don't get the day off here, maybe that's part of it?
A very moving post — Barbara
Thanks, Barbara. I'd originally intended to post about poppies, but it somehow morphed along the way.
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Gnu atheism, women's rights, internationalism, universalism, and gossip
Ophelia Benson is a columnist for Free Inquiry and The Freethinker, and the co-author of The Dictionary of Fashionable Nonsense, Why Truth Matters, and Does God Hate Women.
Hoping to hear
A fundamental human need
The Supreme Court struck a blow at the heart of the Voting Rights Act
Hands off god
Bobcats belong in Joshua Tree
Guest post: People uncritically generalizing their personal experience
Vegan, gluten free, raw
A horribly effective silencer
Even a joke should have some meaning
Corinne on A horribly effective silencer
Dark Jaguar on Hands off god
Dark Jaguar on The Supreme Court struck a blow at the heart of the Voting Rights Act
Dark Jaguar on A fundamental human need
The exploratory mindset - Butterflies and Wheels on The art of the question
ex home birther on Guest post: Has the world been made safer and more welcoming for trans people by this clusterfuck?
Guest post: More dishonest overgeneralizing - Butterflies and Wheels on Hoping to hear
John Horstman on Hoping to hear
omar on Bobcats belong in Joshua Tree
Brian Pansky on A fundamental human need
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B&W Archives
Visit the complete Butterflies & Wheels archives for posts going back to 2000!
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Mythologized Cowboy as Anti-Immigrant Narrative
A mission to the preachers
Janet Heimlich wants to get atheists talking to clerics in order to do a better job of fixing the (enormous and terrible) problem of religious child abuse. She has a post on the subject on her blog.
I've been speaking on the subject of religious child maltreatment for some time, and a glance at my speaking schedule shows what groups have been most eager to have me come talk about this topic. While some religious organizations have extended invitations, I have been welcomed by atheist groups more than any other by far. I can think of all kinds of reasons why this would be, but the fact remains, atheists are willing to learn about religious child maltreatment more than any other group. [Read more…]
Notes and Comment Blog
Giles Fraser versus human rights
Giles Fraser strongly disapproves of the idea (and the judicial finding) that non-medical circumcision is what it is: genital cutting of an infant for religious reasons.
Generally, the logic behind these moves is that circumcision is an act of unnecessary violence against a child and that it is imposing a belief system against a child's will. If an adult wants to be circumcised, so be it. [Read more…]
Children were born
Some ways of living are better than others. Some basic constituents of a good life are fresh air, freedom of movement, access to the wider world. Ways of living that provide more of those basic constituents are generally better than those that don't.
Living underground, for instance. Not ideal.
MOSCOW – A self-proclaimed prophet had a vision from God: He would build an Islamic caliphate under the earth.
The digging began about a decade ago, and 70 followers moved into an eight-level subterranean honeycomb of cramped cells with no light, heat or ventilation.
Children were born. They, too, lived in the cold underground cells for many years — until authorities raided the compound last week and freed 27 sons and daughters of the sect.
Ages 1 to 17, the children rarely saw the light of day and had never left the property, attended school or been seen by a doctor, officials said Wednesday.
Human moles, in other words. Not ideal. Not one of the better ways of living. Not responsible parenthood.
Marry the nice rapist, dear
Oh, human beings, sometimes I despair of you. The arrangements you come up with! Do you just get shit-faced drunk one night and decide all the rules, or what?
There's this idea that letting a rapist avoid jail by "marrying" the young girl he repeatedly raped, for instance – that's a real dud. I'll tell you why. You forgot the girl!! It's about the man who did the raping, and the men who own the girl. This means a shit life for the girl! Did you just not notice that, or what? Pay attention, ffs.
In April, the unidentified girl was shopping in the northern city of Zarqa when a 19-year-old man kidnapped her, took her to the desert where he had a pitched a tent and raped her for three consecutive days, judicial sources said.
She's 14. [Read more…]
Those "moderate" Islamists running Egypt
Like Freedom and Justice Party MP Azza al-Garf, who publicly supports FGM.
Egypt's New Women Foundation said they are suing Islamist Parliament member Azza al-Garf over her pro-female genital mutilation (FGM) statements. The women's rights foundation sent a letter to the speaker of parliament Saad al-Katatny, informing him of legally going after Garf and asking for his permission to be allowed to take the MP to court.
Garf was reported saying that FGM is an Islamic practice and that the anti-FGM laws should be amended. Garf is a Freedom and Justice Party (FJP) member, the political arm of the Muslim Brotherhood in Egypt.
"We are on our way to sue Garf to preserve our rights and the gains of Egyptian women," said the open letter to the speaker.
"We are suing her for going against Egyptian laws that criminalize sexual harassment and FGM, practices that goes against women rights and human rights.
"We completely refuse Garf's statements and announce that she does not represent us."
But Garf thinks Allah wants little girls' genitalia chopped off. Garf worships an evil shit.
Mary Raftery
RTÉ remembers Mary Raftery.
Ms Raftery was best known for her 'States of Fear' documentary series, which revealed the extent of physical and sexual abuse suffered by children in Irish industrial schools and residential institutions.
It led to the creation of the Commission of Inquiry into Child Abuse.
In 2002, her 'Cardinal Secrets' programme for RTÉ's Prime Time led to the setting up of the Murphy Commission of Investigation into clerical abuse in the Dublin Archdiocese.
So did survivors of abuse. [Read more…]
The Irish government again notes that the Catholic church failed to prevent child abuse by its own employees, failed to follow its own rules, failed to call the cops, failed to protect children, failed to act like decent human beings, failed failed failed. It succeeded at protecting itself and its own people, and that's it.
Minister for Justice Alan Shatter has highlighted the failure of the Catholic Church to bring child abuse allegations to the attention of gardaí, following the publication of previously redacted portions of the Cloyne report. [Read more…]
Mutilate the baby tastefully
Parents shouldn't mutilate their children, amirite? I think that's a pretty safe claim. But….
But it turns out it's ok, as long as you make a show of angst about it first. It's ok as long as you go on and on and on about your feelings on the subject, demonstrating how sensitive you are, and then in the end agree to lopping off a bit of your baby's penis. The show of angst makes it ok, so it turns out that the mutilation of the baby is actually all about the feelings of the mommy.
Ever outspoken about what I considered the "barbaric" nature of the bris ritual, it is no wonder I was blessed with two sons. Experiencing it once was pure agony. But it was as I stood on the sidelines awaiting my younger son's circumcision, in pensive conversation with my brother, that I realized I — and women like me — deserved to shed our status as victims and claim our own meaning in this tradition.
And so she does, at great and self-indulgent (or is that "pensive"?) length.
These days, the recent ballot initiative in San Francisco to ban the circumcision of minors (ultimately stricken by a local judge on a technical matter) is the latest manifestation of the growing anti-circumcision movement. Like shirking vaccinations, shedding strollers in favor of "baby wearing," and embracing co- sleeping, it is increasingly popular to resist subjecting your newborn to such a "barbaric" procedure against his "will," and to casually throw around terms like "genital mutilation." Great. Just what I needed to add to my ambivalence over the decision to circumcise my sons — a healthy dose of the liberal guilt I thought I safely had left behind in college.
But I did not find the cries of the hyper-liberal terribly persuasive. Yes, choosing to circumcise your son involves making a difficult and significant decision on his behalf — but what in parenting doesn't? And, after all, isn't the irrationality bred of cult-like child-centric parenting ultimately akin to religious zealousness? Just trendier.
Yes, parents have to make many decisions for their children, but no, that doesn't make it ok to snip off a bit of a baby's penis for reasons of religion or tradition.
I chose to be awakened from my womb-like slumber, along with my new son, and confront that, while his pain may be my own, I cannot always protect him. Neither from physical discomfort, nor from the weight of the traditions into which he was born. For me, the bris served as an important reminder that there are things larger than me and my quest for rationality. Larger than my son and this brief encounter with pain. As one parent wrote about giving his son over for his bris, "I submit him [for circumcision] because I hope there is more to this than I can see or understand." There are things I can't explain, things beyond my control, even — especially — when it comes to this new life.
So she just abdicates responsibility, and lets it happen, because religion is bigger than she is. Therefore what? It's ok to keep children out of school, to forbid girls to go to school, to hire people to hit children with metal poles, to marry little girls to adult men, to mutilate children's genitals?
It's a sad spectacle, someone going to all that trouble to come to a hopeless conclusion.
Update: Stewart did a graphic response so I helped myself to it.
Here he is, he's all yours
Some parents in Irvine California suspected their son, age 15, of smoking. So they sat him down and explained to him how useful it is to be able to breathe freely, how addictive tobacco is, how bad smoking makes you smell, right?
Not quite. They asked a guy to beat the kid up for them (authorities said).
An Irvine couple who suspected their 15-year-old son of smoking turned to a man believed to be relied on in their church to violently discipline children, authorities said. [Read more…]
On religious grounds
Human Rights Watch on child (meaning girl) marriage in Yemen.


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2013-14 (Sophomore): Saw action in 29 contests including four starts…Averaged 4.9 points and 4.6 rebounds per game…Averaged 25.3 minutes per contest…Torched TSU for a career-high, 22-point, 11 rebound effort on Nov. 18…Made a career-high 11 free throws on 16 attempts in that contest against the Tigers.
2012-13 (Freshman): Played in 18 games averaging 9.6 minutes per outing…Averaged 2.6 points per game…Scored a season high seven points three times (at Mercer-2/21/13, at Northern Kentucky-1/11/13, USC Upstate (1/7/13)…Hit 2-of-3 three pointers…2013 Atlantic Sun Conference Scholar.
High School: Prepped at Salpointe Catholic under coach Brian Holstrom…earned first-team Arizona Star all-state honors as a senior…averaged 15.3 points, 9.1 rebounds and 2.3 steals per game as a senior…garnered first-team All-Southern Arizona honors by the Tuscon Citizen as a senior…named all-region and all-district as a junior and senior…captained the Lancers as a senior…posted a 4.1 grade point average in the classroom.
Personal: Son of Steve and Tracy Denny…has one brother (Blake) …also recruited by Washington State, Idaho State, San Diego, Houston Baptist, New Hampshire and USC Upstate.


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AFCON coverage brought to you by
Eguavoen identifies one weak area Super Eagles need to work on after Guinea-Bissau win
in AFCON, News, NewsNow, Nigeria
The 2013 Afcon kings have won three matches on the trot, the only side to have achieved that in Cameroon, but their boss insists they are not the finished product just yet
Interim head coach Augustine Eguavoen has revealed a significant weakness on the Super Eagles, which they must strengthen to brighten their chances of winning the 2021 Africa Cup of Nations.
Eguavoen is still not impressed with the Eagles' attack, especially in finishing off created opportunities, despite the team recording a comfortable 2-0 win over Guinea-Bissau in Garoua on Wednesday.
The 56-year-old tactician left attacking trio Taiwo Awoniyi, Samuel Chukwueze, and Joe Aribo entirely out of the match and only introduced Moses Simon from the bench.
Still, Nigeria dominated Guinea-Bissau with more than 60 per cent of the ball possession, firing ten shots, six of which were on target. With a more efficient striker in attack, the Eagles could have scored one or two more goals against the African Wild Dog.
Overall, the Super Eagles have scored six goals in three games. Still, Eguavoen laments the team's inability to finish their chances and wants them to do better with sterner opponents awaited in the knockout stages.
"We always create chances," Eguavoen told ESPN.
"The problem is finishing them off. That is what we have to keep working on as we go further."
With the win over Guinea-Bissau, Nigeria became the only team in Cameroon to have won all their three group stage matches.
The Super Eagles will next face the third-placed team in Group E or F in a round of sixteen clash on Sunday, January 23.


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Culture&arts
Gadgets and Science
Movie&tv
Without further ado, here is a look at the 10 most expensive hotels in the world.
The Most Unusual Tourist Attractions In The World
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6 Mysterious Spots Hidden in Famous Locations
There are secret rooms all over the world, and many of them are hidden inside popular places and landmarks visited by a slew of tourists every day? Sounds great? Then let's go visit 6 mysterious spots hidden in famous locations!
8 Most Underrated Global Destinations to Visit in 2018
Summer is here, and many of you are considering where to go for your annual vacation, so why not go off the beaten path and try out one or more of these 8 highly underrated destinations?
These Pictures Show Dubai And Abu Dhabi Being Retaken By The Desert
We all know that Dubai and Abu Dhabi have some of the most beautiful architecture, growing from a forgotten place in the middle of the desert into an amazing metropolis that evokes awe whenever you see it. Sadly for Abu Dhabi and Dubai, the desert they were built in, isn't too keen on keeping them around. It's slowly but surely taking back whatever roads and buildings people built, and it's creating some magnificent imagery.
14 Most Amazing Caves in the World
There are millions of mysterious and fantastic-looking places on our planet. From the gorgeous waterfalls, and mountain peaks, to underwater reefs and volcanoes. But, perhaps, the most wonderful places to visit in the wild outdoors are the caves. These underground cavities can sometimes look pretty majestic!
8 Life-Changing Getaways For Spiritual Seekers
You don't have to travel to the other side of the world to get a life-changing experience, but it is still good to get a change of scene, explore exotic cultures and spend peaceful evenings high up in the mountains. There are also places that are considered special and highly spiritual, possessing some special qualities that are hard to explain with words, you can only go there and experience everything yourself. We present to you 8 spectacular getaways that will change your life forever.
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National Geographic's Must-See Travel Destinations For 2018
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SEVENDUST'S LAJON WITHERSPOON & CLINT LOWERY TO GUEST ON THE INFINITE STAIRCASE'S NEW EP.
On the heels of the recently announced collaboration with Savatage and Trans-Siberian Orchestra guitar virtuoso Chris Caffery, New York-based outfit, The Infinite Staircase (comprised of brothers Lenny and Jeff Cerzosie), have added a few more recognizable names in the hard rock and heavy metal community to their already "rock star-studded" forthcoming Ep; this time in the form of the album's producer/drummer Morgan Rose's longtime bandmates, both Sevendust's guitarist Clint Lowery and frontman, Lajon Witherspoon.
Lowery plays on the track "Can't Control It", while Witherspoon sings alongside The Infinite Staircase frontman Lenny Cerzosie on "Just To Meet You There" and what has now been confirmed as the forthcoming new single, "The Things We've Done".
These collaborations mark the finishing touches on the band's forthcoming as yet untitled Ep, which is expected to be released in late summer or early fall with the first single hitting radio within the next few weeks.
The Infinite Staircase has made a habit in recent years of collaborating with some of the most respected musicians in hard rock and heavy metal. In 2009, the band's debut album 'The Road Less Taken' featured guest appearances by Blues Saraceno (Poison) and Earl Slick (David Bowie, John Lennon). Saraceno also mixed the record.
In 2012 the band began work on their follow-up with Sevendust and Call Me No One drummer Morgan Rose at the helm, producing as well as taking charge behind the kit. Early sessions brought in collaborations with Sean Memphis Hennesy (Candlebox, The Gracious Few), John "JD" DeServio (Black Label Society, Cycle Of Pain) and Troy Cromwell (Cycle Of Pain).
Then, on October 22nd, 2012 came Hurricane Sandy and The Cerzosie brothers found themselves organizing an All-Star collaboration to raise money for the victims of the storm; a collaboration which consisted of, in addition to Morgan Rose and JD DeServio, Guitar God Zakk Wylde and Candlebox frontman Kevin Martin. What resulted was "The Pride", a melodic mid-tempo rocker with blazing solos and screeching vocals which spent 6 weeks on America's Music Charts' Mainstream Rock Radio Top 40 with it's highest ranking being #27.
"The Pride" was released digitally on February 5th, 2013 via Vanity Music Group with 100% of the proceeds being donated to the Carl Vincent Bini Memorial Foundation. The song was recorded at Architekt Music, the state of the art recording facility in Butler, New Jersey where Sevendust recently tracked 'Black Out The Sun'. It was mixed by house engineer Mike Ferretti (Sevendust, Call Me No One) and mastered by Alan Douches (Fleetwood Mac, Yes) at West Side Music in New Windsor, New York. The song is available via digital retailers such as iTunes, Amazon & Google Play, or a limited edition CD Single can be purchased via theinfinitestaircase.bigcartel.com.


text:
Čedomir je moško osebno ime.

Različice imena
 Moške oblike Imena:Čeda, Čedo
 Ženske oblike imena:Čede, Čedina, Čedinka, Čedna, Čedomila, Čedomira,Čedomirka

Izvor imena
Ime Čedomir je južnoslovansko in je zloženo iz besede čédo »otrok,dete« in priponke mir.

Pogostost imena
Leta 1994 je bilo po podatkih iz knjige Leksikon imen Janeza Kebra v Sloveniji193 nosilcev imena Čedomir.

Po podatkih Statističnega urada Republike Slovenije je bilo na dan 31. decembra 2007 v Sloveniji število moških oseb z imenom Čedomir:124. Med vsemi moškimi imeni pa je ime Čedomir po pogostosti uporabe uvrščeno na 535 mesto.

Osebni praznik
V koledarju ni imena Čedomir, glede na končnico -mir pa bi ga lahko uvrstili k imenu Miroslav oziroma Friderik, ki praznujeta god 18. julija.

Glej tudi
 seznam osebnih imen na Č

Viri

Moška osebna imena


text:
UK/
The future of science
Written by Laura Cole
Published in UK
Professor Brian Cox checking out a groundbreaking fusion reactor, one of 22 exhibits at the Summer Exhibition Royal Society
At the Royal Society Summer Exhibition, Geographical talks to Professor Brian Cox about public engagement and why it's vital for the future of science
Groups of students buzz around booths showcasing some of the most state-of-the-art research in the UK. A 3D printed replica of Richard III's excavated remains is on display in the main lecture hall, watching idly on as a team of University College London PhDs put their heads together to explore the possible origins of life. Upstairs, scientists from the National Physics Laboratory let students try on augmented reality headsets, while a group from Rothamsted Research gesture towards different species of grass that cattle might need to eat if we want to make beef farming more sustainable.
The Summer Exhibition is free for everyone, but it seems that schools and colleges are making the most of the outing. 'I always expect, in fact I know that students are interested in science,' says Brian Cox OBE, Professor of Particle Physics and the Society's Professor of Public Engagement, 'But here especially, because the standard of the exhibits is so high, most of them are really right on the edge of current research.'
The exhibition takes place every year and has done since 1992. However, the tradition of exhibiting the latest scientific research goes back to the 18th century, when the Society held soirées. These were 'social and cultural feasts,' says Keith Moore, the Society's Head of Library and Archive Services. 'Soirées also gave women scientists their earliest opportunity to share their expertise with a high-level audience of their peers.' The aim is still to be inclusive – crucially so given the vast skill shortage in the science, engineering and technology industries in the UK. Events like the Summer Exhibition are an opportunity for students to see the approachable, less intimidating side of science.
The Stonehenge Hidden Landscapes exhibit. The team used ground penetrating radar to survey hidden features around Stonehenge (Image: Royal Society)
'There's this figure which goes around at the moment which says that we need about one million more engineers by 2020,' says Cox, 'and that's just engineers. The same goes for huge shortages in physics, biosciences and medical scientists as well. The students here might be the people to fill those jobs. At this stage, their decisions can be effected by the smallest of things and this glimpse into the world of research can change how they feel about certain routes into the subjects.'
This can be particularly important for girls thinking about pursuing science. Many universities talk about the gender gap in scientific disciplines, particularly in engineering and physics and it often causes public debate. 'There's a perception with physics that it's male dominated, which it is less and less actually,' explains Cox. 'Perceptions like that can affect some boys getting into physics as well because they might not want to go into a discipline that's male dominated. But if students are coming here and seeing some of the female scientists that are working on molecular physics at CERN, for example, they might identify with someone. From my personal experience at the University of Manchester, I think we're pretty much 50/50 men and women. But if you were interested in particle physics you'd need to know that. Events like this can readdress some of those perceptions.'
Attitudes towards science are always fluctuating. However, the glut of science news surrounding topics like climate change and health means that reporters often reach for the most interesting – and occasionally inaccurate – data. This coupled with soundbite university press releases, often give research a hyperbolic attitude, which can be misread or taken out of context. Mistakes and exaggeration can impact the confidence in scientific claims.
'It damages public debate actually,' says Cox. 'Ideally what you want is an overview of things like climate science, something with a level of scientific literacy and factuality which allows people to step back and ask what's the best, current view with convincing evidence. Some views would contradict each other because that's the way science is. But in order to make your way through that minefield, you've got to not treat scientists like priests who say "this is the way it is" because scientists don't know. They just say "to the best of my knowledge at the moment this is what I think".'
Featuring a range of talks, family shows and panel discussions, the Summer Exhibition will run until 5 July at the Royal Society in London.
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Assignment #1 Fiction: A Rose For Emily Eng 1 B Essay
Cobarrubio 1
Regina Cobarrubio
ENG 1B
Professor Anguiano
12 , March 2019
Fiction: A Rose for Emily
"One reason people resist change is because they focus on what they have to give up,
instead of what they have to gain". In the short story, "A Rose for Emily" by William Faulkner,
the protagonist, Emily Grierson, was born into a old southern family where she was controlled
by her father. This was a time soon after civil war where she was not able to accept the
reconstruction of the town. She lived a certain lifestyle where everything remained the same until
her father's death. After Emily's father's passing, her life slowly began to change without her
consent. Emily entered a state of denial. This is when Emily's life started to spiral out of control.
Although Emily was not willing to accept the change she learns that change is inevitable. The
author uses different fiction elements to help demonstrate and support thesis "change is
inevitable". Faulkner starts by creating the story's setting, post civil war, where the town was
undergoing reconstruction. Plot comes in and exemplifies the important events and how they
correlate to the story's theme. Making connections the reader can use symbolism to connect the
main points and theme of the story.
The setting is extremely important to a story. It can have immense effects on the plot and
the characters. Also, the setting can do more than affect plot events, it can also establish the
atmosphere, or mood, of a story or a specific scene. This short story takes place in a small
fictional town called Jefferson located in the south, shortly after the civil war. That type of
setting helps create a bigger image and deeper understanding of the story's theme. This setting
also construct a melancholy and mournfulness atmosphere. The descriptions of the setting push
the reader to gain a sense of the concerns of the towns people amongst Miss Emily's feelings
moving forward into a new generation, and thus the suspenseful mood is created. The setting
establishing this mood allows the reader to relate to the characters within a story. The home that
Emily shares with her father and eventually inherits is symbolic of Emily's inner state. As the
story opens, the house is lively and fresh, with clean, white walls. Emily also is lively and fresh
in her youth. Her father protects her purity by turning away any men he doesn't believe measure
up to her standards. In this case everyman who showed interest in Emily. As the story
progresses, the house becomes dirty, smelly and foul. The smell was so horrid that the
townspeople began to complain. Soon they took matters into their own hands. As demonstrated
in quote,"They broke open the cellar door and sprinkled lime there, and in all the outbuildings"(
Faulkner P. 79). Four men went to Emily's doing this in hopes to get rid of the smell. At the
same time, Emily grows older and her spirit more deranged. She plunges into madness, not only
killing her fiance but...
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This will present the Country Club with an opportunity to influence its central competencies as regards servicing the traveller in a swish environment.
The mission for Lidlington Golf Club is committed to providing a facility that is committed to serving golfers and extra tourists in the hunt for a distinctive location. The mission of the Country Club is to become the number one choice of visitors to Lidlington.
Lidlington Golf Club will strive to make each patron be of the opinion that they are of great consequence to our business and will give each customer value for their cash.