text:
Home » Blog » Google Play revenue has been disclosed for the first time
Google Play revenue has been disclosed for the first time
As part of the next antitrust case against the IT giant Google, which is part of the Alphabet holding; the financial performance of the Google Play app store has been disclosed for the first time.
A number of US states have filed antitrust charges against Google. The claims relate to company policies that govern the Google Play platform. In particular, third-party Android app developers are unhappy with the fact that Google obliges to use its own payment tools when selling subscriptions and content and charges a commission of up to 30% on sales.
According to documents declassified in the framework of antitrust proceedings; in 2019 alone, the Google Play app store received revenue of $ 11.2 billion.
At the same time, gross profit amounted to $ 8.5 billion, and operating profit – approximately $ 7.0 billion. The operating profit margin of the Google Play platform at the end of 2019 exceeded 62%.
Note that these figures take into account the sales of the actual mobile applications, in-app purchases; as well as advertising based on Google Play.
Lawsuits against Google over Play Store fees
It became known that in the UK filed a class-action lawsuit in the amount of £ 920 million ($ 1.3 billion) against Google, accused of "excessive and illegal" prices in the Google Play Store.
The lawsuit, filed with the UK Competition Court of Appeals, alleges that the tech giant is discouraging competition on the Play Store; and is illegally charging a 30 percent commission on in-store purchases. The lawsuit also states that Google is integrating the Play Store with its other products and services; and requires it to be pre-installed and prominently displayed on your desktop.
This discourages competition from other apps on Android devices as the "vast majority" of shoppers are directed to the Google store to shop. The authors of the lawsuit called the 30 percent commission charged by Google on app purchases as "illegal and unearned fees charged to ordinary people for no reason."
Commenting on the filing of the lawsuit, a Google spokesman said: "This lawsuit ignores the advantages and choices provided by Android and Google Play, as well as the competitive market in which we operate".
Also, according to Google, consumers and developers have a choice of competing app stores; while consumers can download other apps or entire app stores, allowing them to do without Google Play altogether.
Earlier this year, the UK filed a similar class action lawsuit against Apple; seeking compensation in the amount of £ 1.5bn ($ 2.1bn).
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text:
#import "YapDatabaseFilteredViewConnection.h"
#import "YapDatabaseFilteredViewPrivate.h"
#import "YapDatabaseLogging.h"

#if ! __has_feature(objc_arc)
#warning This file must be compiled with ARC. Use -fobjc-arc flag (or convert project to ARC).
#endif

/**
 * Define log level for this file: OFF, ERROR, WARN, INFO, VERBOSE
 * See YapDatabaseLogging.h for more information.
**/
#if DEBUG
  static const int ydbLogLevel = YDB_LOG_LEVEL_WARN;
#else
  static const int ydbLogLevel = YDB_LOG_LEVEL_WARN;
#endif

@interface YapDatabaseFilteredView ()

/**
 * This method is designed exclusively for YapDatabaseFilteredViewConnection.
 * All subclasses and transactions are required to use our version of the same method.
 *
 * So we declare it here, as opposed to within YapDatabaseViewPrivate.
**/
- (void)getGroupingBlock:(YapDatabaseViewGroupingBlock *)groupingBlockPtr
       groupingBlockType:(YapDatabaseViewBlockType *)groupingBlockTypePtr
            sortingBlock:(YapDatabaseViewSortingBlock *)sortingBlockPtr
        sortingBlockType:(YapDatabaseViewBlockType *)sortingBlockTypePtr
          filteringBlock:(YapDatabaseViewFilteringBlock *)filteringBlockPtr
      filteringBlockType:(YapDatabaseViewBlockType *)filteringBlockTypePtr;

@end

////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////
#pragma mark -
////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////

@implementation YapDatabaseFilteredViewConnection

#pragma mark Accessors

- (YapDatabaseFilteredView *)filteredView
{
	return (YapDatabaseFilteredView *)view;
}

////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////
#pragma mark Transactions
////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////

/**
 * Required override method from YapDatabaseExtensionConnection.
**/
- (id)newReadTransaction:(YapDatabaseReadTransaction *)databaseTransaction
{
	YapDatabaseFilteredViewTransaction *filteredViewTransaction =
	  [[YapDatabaseFilteredViewTransaction alloc] initWithViewConnection:self
	                                                 databaseTransaction:databaseTransaction];

	return filteredViewTransaction;
}

/**
 * Required override method from YapDatabaseExtensionConnection.
**/
- (id)newReadWriteTransaction:(YapDatabaseReadWriteTransaction *)databaseTransaction
{
	YapDatabaseFilteredViewTransaction *filteredViewTransaction =
	  [[YapDatabaseFilteredViewTransaction alloc] initWithViewConnection:self
	                                                 databaseTransaction:databaseTransaction];

	[self prepareForReadWriteTransaction];
	return filteredViewTransaction;
}

////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////
#pragma mark Changeset Architecture
////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////

/**
 * Invoked by our YapDatabaseViewTransaction at the completion of the rollbackTransaction method.
**/
- (void)postRollbackCleanup
{
	YDBLogAutoTrace();

	// Don't keep cached blocks in memory.
	// These are loaded on-demand withing readwrite transactions.
	if (filteringBlock) {
		filteringBlock = NULL;
		filteringBlockType = 0;
	}

	filteringBlockChanged = NO;

	[super postRollbackCleanup];
}

/**
 * Invoked by our YapDatabaseViewTransaction at the completion of the commitTransaction method.
**/
- (void)postCommitCleanup
{
	YDBLogAutoTrace();

	// Don't keep cached blocks in memory.
	// These are loaded on-demand withing readwrite transactions.
	filteringBlock = NULL;
	filteringBlockType = 0;

	filteringBlockChanged = NO;

	[super postCommitCleanup];
}

- (void)getInternalChangeset:(NSMutableDictionary **)internalChangesetPtr
           externalChangeset:(NSMutableDictionary **)externalChangesetPtr
              hasDiskChanges:(BOOL *)hasDiskChangesPtr
{
	YDBLogAutoTrace();

	NSMutableDictionary *internalChangeset = nil;
	NSMutableDictionary *externalChangeset = nil;
	BOOL hasDiskChanges = NO;

	[super getInternalChangeset:&internalChangeset
	          externalChangeset:&externalChangeset
	             hasDiskChanges:&hasDiskChanges];

	if (filteringBlockChanged)
	{
		if (internalChangeset == nil)
			internalChangeset = [NSMutableDictionary dictionaryWithSharedKeySet:sharedKeySetForInternalChangeset];

		internalChangeset[changeset_key_filteringBlock] = filteringBlock;
		internalChangeset[changeset_key_filteringBlockType] = @(filteringBlockType);

		// Note: versionTag & hasDiskChanges handled by superclass
	}

	*internalChangesetPtr = internalChangeset;
	*externalChangesetPtr = externalChangeset;
	*hasDiskChangesPtr = hasDiskChanges;
}

////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////
#pragma mark Internal
////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////

/**
 * Used when the parentView's groupingBlock/sortingBlock changes.
 *
 * We need to update our groupingBlock/sortingBlock to match,
 * but NOT the versionTag (since it didn't change).
**/
- (void)setGroupingBlock:(YapDatabaseViewGroupingBlock)newGroupingBlock
       groupingBlockType:(YapDatabaseViewBlockType)newGroupingBlockType
            sortingBlock:(YapDatabaseViewSortingBlock)newSortingBlock
        sortingBlockType:(YapDatabaseViewBlockType)newSortingBlockType
{
	groupingBlock        = newGroupingBlock;
	groupingBlockType    = newGroupingBlockType;
	groupingBlockChanged = YES;

	sortingBlock        = newSortingBlock;
	sortingBlockType    = newSortingBlockType;
	sortingBlockChanged = YES;
}

- (void)setFilteringBlock:(YapDatabaseViewFilteringBlock)newFilteringBlock
	   filteringBlockType:(YapDatabaseViewBlockType)newFilteringBlockType
               versionTag:(NSString *)newVersionTag
{
	filteringBlock        = newFilteringBlock;
	filteringBlockType    = newFilteringBlockType;
	filteringBlockChanged = YES;

	versionTag        = newVersionTag;
	versionTagChanged = YES;
}

- (void)getGroupingBlock:(YapDatabaseViewGroupingBlock *)groupingBlockPtr
       groupingBlockType:(YapDatabaseViewBlockType *)groupingBlockTypePtr
            sortingBlock:(YapDatabaseViewSortingBlock *)sortingBlockPtr
        sortingBlockType:(YapDatabaseViewBlockType *)sortingBlockTypePtr
          filteringBlock:(YapDatabaseViewFilteringBlock *)filteringBlockPtr
      filteringBlockType:(YapDatabaseViewBlockType *)filteringBlockTypePtr
{
	if (!groupingBlock || !sortingBlock || !filteringBlock)
	{
		// Fetch & Cache

		__unsafe_unretained YapDatabaseFilteredView *filteredView = (YapDatabaseFilteredView *)view;

		YapDatabaseViewGroupingBlock  mostRecentGroupingBlock  = NULL;
		YapDatabaseViewSortingBlock   mostRecentSortingBlock   = NULL;
		YapDatabaseViewFilteringBlock mostRecentFilteringBlock = NULL;
		YapDatabaseViewBlockType mostRecentGroupingBlockType  = 0;
		YapDatabaseViewBlockType mostRecentSortingBlockType   = 0;
		YapDatabaseViewBlockType mostRecentFilteringBlockType = 0;

		BOOL needsGroupingBlock = (groupingBlock == NULL);
		BOOL needsSortingBlock = (sortingBlock == NULL);
		BOOL needsFilteringBlock = (filteringBlock == NULL);

		[filteredView getGroupingBlock:(needsGroupingBlock ? &mostRecentGroupingBlock : NULL)
		             groupingBlockType:(needsGroupingBlock ? &mostRecentGroupingBlockType : NULL)
		                  sortingBlock:(needsSortingBlock ? &mostRecentSortingBlock : NULL)
		              sortingBlockType:(needsSortingBlock ? &mostRecentSortingBlockType : NULL)
		                filteringBlock:(needsFilteringBlock ? &mostRecentFilteringBlock : NULL)
		            filteringBlockType:(needsFilteringBlock ? &mostRecentFilteringBlockType : NULL)];

		if (needsGroupingBlock) {
			groupingBlock      = mostRecentGroupingBlock;
			groupingBlockType  = mostRecentGroupingBlockType;
		}
		if (needsSortingBlock) {
			sortingBlock       = mostRecentSortingBlock;
			sortingBlockType   = mostRecentSortingBlockType;
		}
		if (needsFilteringBlock) {
			filteringBlock     = mostRecentFilteringBlock;
			filteringBlockType = mostRecentFilteringBlockType;
		}
	}

	if (groupingBlockPtr)      *groupingBlockPtr      = groupingBlock;
	if (groupingBlockTypePtr)  *groupingBlockTypePtr  = groupingBlockType;
	if (sortingBlockPtr)       *sortingBlockPtr       = sortingBlock;
	if (sortingBlockTypePtr)   *sortingBlockTypePtr   = sortingBlockType;
	if (filteringBlockPtr)     *filteringBlockPtr     = filteringBlock;
	if (filteringBlockTypePtr) *filteringBlockTypePtr = filteringBlockType;
}

/**
 * Overrides method in YapDatabaseView
**/
- (void)getGroupingBlock:(YapDatabaseViewGroupingBlock *)groupingBlockPtr
       groupingBlockType:(YapDatabaseViewBlockType *)groupingBlockTypePtr
            sortingBlock:(YapDatabaseViewSortingBlock *)sortingBlockPtr
        sortingBlockType:(YapDatabaseViewBlockType *)sortingBlockTypePtr
{
	[self getGroupingBlock:groupingBlockPtr
	     groupingBlockType:groupingBlockTypePtr
	          sortingBlock:sortingBlockPtr
	      sortingBlockType:sortingBlockTypePtr
	        filteringBlock:NULL
	    filteringBlockType:NULL];
}

- (void)getFilteringBlock:(YapDatabaseViewFilteringBlock *)filteringBlockPtr
       filteringBlockType:(YapDatabaseViewBlockType *)filteringBlockTypePtr
{
	[self getGroupingBlock:NULL
	     groupingBlockType:NULL
	          sortingBlock:NULL
	      sortingBlockType:NULL
	        filteringBlock:filteringBlockPtr
	    filteringBlockType:filteringBlockTypePtr];
}

@end

redpajama_set_name: RedPajamaGithub


text: Q: Has anyone used Perl to access the new GA4 API? I have a perl based reporting system and currently use Net::Google::Analytics but am looking to migrate from universal analytics to the new ga4 api and am struggling to find where to start. Anyone else done it yet?

redpajama_set_name: RedPajamaStackExchange


text:
Q: Proof of $\lim\limits_{n\to\infty} \frac{a^n}{n!}=0$ $\lim\limits_{n\to\infty} \frac{a^n}{n!}=0$
how to prove this one since L'Hospital Theorem cannot be used with factorial?

A: Hint. Let $N\geq |a|$, then for $n>N$, we have that
\begin{align*}
0\leq \frac{|a|^n}{n!}&=\frac{|a|}{n}\cdot \frac{|a|^{n-N-1}}{(n-1)\cdots (N+1)}\cdot \frac{|a|^{N}}{N!}\\
&\leq \frac{|a|}{n}\cdot \left(\frac{|a|}{N+1}\right)^{n-N-1}\cdot \frac{|a|^{N}}{N!}\\
&\leq \frac{|a|}{n}\cdot \frac{|a|^{N}}{N!}
\end{align*}
then apply the Squeeze Theorem as $n\to \infty$.

A: Stirling: $n! \sim (\frac{n}{e})^n \sqrt{2\pi n}$
$\frac{a^n}{n!} \sim \frac{a^n e^n}{n^n\sqrt{2\pi n}} = (\frac{a\times e}{n})^n \frac{1}{\sqrt{2\pi n}} = \exp(n \ln(\frac{a\times e}{n})) \frac{1}{\sqrt{2 \pi n}} \rightarrow 0$

A: $$\frac{a^n}{n!} = \frac{a^k}{k!}\cdot \frac{a^{n-k}}{(k+1)\cdot(k+2)\cdots n!}\leq C\cdot\frac{a^{n-k}}{(a+1)^{n-k}}$$
for some constant $c$ and a large enough value of $k$ (i.e., a value of $k$ such that $k>a$).

A: One can also show by D'Alembert's criterion criterion that the series $$\sum_{n=1}^{\infty} \frac{a^n}{n!}$$ converges, so the limit of the summand must be zero.
(This is rather a funny fact than a real solution, since the technique used in the proof of the criterion can be used directly to prove that the limit is zero).

A: If we apply the ratio test, we find that
$$
\lim_{n \to \infty}\frac{a^{n+1}}{(n+1)!}\cdot \frac{n!}{a^n} = \lim_{n \to \infty} \frac{a}{n+1} = 0
$$
Typically, we use this to deduce that $\sum \frac{a^n}{n!}$ converges.  However, it is certainly enough to deduce that $\frac{a^n}{n!} \to 0$, since this is a requirement for the above convergence.

A: $$0<\left| \frac { { a }^{ n } }{ n! }  \right| =\frac { \left| a \right|  }{ 1 } \frac { \left| a \right|  }{ 2 } \frac { \left| a \right|  }{ 3 } ...\frac { \left| a \right|  }{ m } \quad \frac { \left| a \right|  }{ (m+1) } ...\frac { \left| a \right|  }{ n } \le \frac { \left| { a }^{ m } \right|  }{ m! } { \left( \frac { \left| a \right|  }{ m+1 }  \right)  }^{ n-m }<\varepsilon \\ $$
for every $\forall \varepsilon >0$ and $m+1 >\left|a\right|$


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text:
AAMCNews
Making science serve humanity: Jennifer Doudna, PhD, says CRISPR gene-editing technology should be accessible to all
The co-winner of the 2020 Nobel Prize in chemistry shared insights into the clinical potential of gene editing, the importance of equity, and how CRISPR could help fight future pandemics at Learn Serve Lead 2021, the AAMC's annual meeting.
By Bridget Balch, Staff Writer
Jennifer Doudna, PhD, Nobel Prize co-winner for developing CRISPR gene-editing technology, speaks with session moderator, J. Larry Jameson, MD, PhD, chair of the AAMC Board of Directors, at Learn Serve Lead 2021: The Virtual Experience on Nov. 8.
Photo by Laura Zelaya, AAMC
The path that led Jennifer Doudna, PhD, and her colleagues to the development of CRISPR, the gene-editing tool that has revolutionized science and earned her a Nobel Prize, started with their deep curiosity and drive to understand how the most basic building blocks of life function.
When Doudna first decided to investigate precisely what systems bacteria use to adapt their immune systems to fight off viral infections, she had little expectation that the findings would ultimately provide the key to technology that could be used to safely alter genetic code.
"All of us [on the research team] realized that what had started as a fundamental research question was morphing into a very different kind of project; namely, one with enormous technical potential and also risks and opportunities that we had not appreciated when we started the work," Doudna explained during a conversation with J. Larry Jameson, MD, PhD, chair of the AAMC Board of Directors and executive vice president of the University of Pennsylvania Health System, at the opening plenary of Learn Serve Lead 2021: The Virtual Experience, on Monday, Nov. 8.
Doudna, who runs a laboratory at the University of California, Berkeley, and founded the Innovative Genomics Institute, which works to advance genome research in a way that benefits humanity equitably, gave a presentation explaining the science behind CRISPR technology before engaging in a discussion with Jameson and attendees about the technology's potential opportunities and risks.
"It's been extraordinary to see how fast CRISPR has taken off in labs around the world," Doudna said, listing examples of clinical trials already underway to use CRISPR to treat illnesses such as sickle cell disease, congenital blindness, and cancer. She added that, within the next two decades, CRISPR could even be used to treat more common ailments, such as dementia and cardiovascular disease, and to bolster immunity against pathogens that might cause future pandemics.
Still, despite reveling in the great power of the technology, Doudna emphasized the responsibility she feels to advocate for its ethical use.
"Like any new technology, CRISPR comes with risks," she said. "It was clear early on that there were going to be some real ethical challenges."
Those challenges include ensuring there are internationally recognized regulations for the use of CRISPR — including addressing the idea of creating "designer babies" — and the need to ensure the treatments derived from it are affordable and accessible to people from all socioeconomic groups across the globe.
"We have to be cognizant of how to be sure that everyone who can benefit from this technology has access to it," Doudna said. "That's something I'm very deeply committed to."
An important key to making progress in science is by embracing collaboration, especially by including people from diverse backgrounds in the lab, she added.
"There's nothing better than having people from different parts of the world, different cultural backgrounds, [and] different educational backgrounds who converge on a question or a problem," Doudna said. "In my experience, that type of collaboration often leads to the very best outcomes in science."
She also acknowledged the research and discoveries that are yet to come that will continue to propel CRISPR and science into a better future. Doudna feels that mentoring the next generation of scientists is among her most important responsibilities.
In a comment directed to students, she said, "It's an extraordinary time to be getting into science. I'm really excited to see what you discover."
In advance of Learn Serve Lead, Doudna spoke with AAMCNews about her hopes for the future of CRISPR, the importance of representation in science, and how academic medicine can improve opportunities for innovation moving forward.
How has this pandemic impacted your work — and how did you shift your own work to respond to the pandemic?
Well, like for many people — maybe everybody — the pandemic really changed the way we're doing research in the laboratory: initially because we were basically prevented from coming into the lab, and then primarily because we decided to focus our efforts on addressing the pandemic by setting up a clinical testing laboratory institute and by working to develop new types of COVID diagnostics. So that was work that started in March of 2020. As a result, we have a CLIA [Clinical Laboratory Improvement Amendments] certified laboratory running on our campus. We run about 15,000-20,000 COVID-19 tests a week for the university community and for a number of our health care partners in the San Francisco and East Bay area. And that's been just amazing. It's been a wonderful opportunity to engage with our community — but [it] also has allowed us to begin accessing and reporting on clinical results and working directly with physicians.
And having this clinical lab has also allowed us to work together with health care partners on advancing the development of CRISPR-based diagnostics. This has led to three new types of diagnostic chemistries that all rely on the CRISPR technology. And we hope that one or more of those will, in fact, have applications for point of care testing. That's something that we're actually exploring currently with a couple of our partners.
CRISPR has had so many research implications. What has it been used for that you find most fascinating or most inspiring so far?
A couple of things come to mind. One is that it's been extraordinary how fast the CRISPR technology has moved into the clinic. We've seen, in less than 10 years, the technology has already gone into Phase 1 trials for a number of different types of diseases, including cancer and disorders of the liver, the eye, and the blood. So far — knock on wood — those trials are going well, and I think there's a lot of momentum in the field right now. I think [there's] a lot of expectation that, within the next five to 10 years, we will see — we hope — approved therapies that rely on fundamentally correcting the disease-causing mutation at the source — you know, in the DNA. It's a different way of thinking about disease. Rather than mitigating the consequences of disease, [scientists are] trying to prevent disease in the first place or cure it, so that patients don't have to deal with the consequences of genetic disease in the future. I think that's really very exciting.
Is that something that you had anticipated coming together as quickly as it has? And what are your long-term hopes for the future of medicine, especially with genetic diseases?
I think it's always hard, in my experience, to predict how fast things will progress when you go into the clinic with human patients. It's really wonderful to see how fast the technology has progressed, but I certainly couldn't have predicted it. The technology works great in the laboratory, but that doesn't necessarily speak to how effective or safe or efficacious it would be in a human. One of the things that I think about the most right now is affordability and accessibility of the technology. It certainly looks right now that, in the future, we will have the ability to use CRISPR to cure genetic diseases. The question will be: Who gets to use [it]? Who can afford those treatments? I think this is so important in terms of thinking about — as the technology advances — how do we, as scientists, make sure that we're addressing some of the technical and scientific issues that could otherwise be barriers to affordability? One example of that is the way that the CRISPR technology is delivered into patients. There's a wide range of methods that could or should or might be used, and they have different costs and timelines associated with them. I think that's one thing that will be very important to address going forward.
You've spoken very publicly about the potential ethical implications of gene editing and how that might be used to make enhanced humans in the future. What are your concerns about the ethics, and how do you think the scientific world and society in general should be talking about this to ensure that this technology is not abused?
Well, first and foremost, I think it's critical to have transparency around the use of the technology. That's one of the reasons that I've been involved, for the past several years, in organizing meetings — both locally and internationally — on the subject. And I think just inviting the scientific community and other stakeholders to engage together on thinking about how this technology is to be used in the future is so important. It's an extraordinary opportunity that we have — but [it] also comes with a lot of responsibility.
You've talked about how, when you were in high school, seeing a woman who was a scientist helped put you on your career path. Why do you think that was important to you to see a woman who was in science?
When I was growing up, my image of a scientist was the classic photograph of Albert Einstein or cartoons of mostly older White men who were in lab coats with black-rimmed glasses and crazy hair. That was the media caricature of a scientist, but I think without even realizing that, I had really internalized that as what a scientist looks like. By definition, a scientist is a man. And for me, being in high school and realizing that I was interested in mathematics and chemistry and biology — and then having the opportunity to see a wonderful presentation from a scientist who happened to be a woman who was working on cancer biology — I just thought that was amazing. And when I saw that talk, I still remember the way I felt. I just thought that "that's what I want to do. I want to be her." And I think it's really important for students to have mentors that they can identify with — people who look like them in some way or make them think that there's a connection between where they are in their life at an early stage of their education and where they could be someday.
What still needs to change in the scientific community to make it more accessible to women — for them to see themselves in that career?
Certainly, having more diversity in science is a good thing. I think that's very important. I think that having opportunities for students in the early part of their training and their education, giving students opportunities to work in labs or hear about research that's going on from different types of scientists — a diverse set of scientists, diverse in all ways, not only in terms of the scientists themselves but also the types of work that they're doing — I think that's critical because, in my experience, kids are natural scientists. They're curious about their world and, unless somebody squelches that, they're interested in the world that we inhabit. Why do we look the way we do? Why does our world work the way it does? All those types of questions. Finding ways to encourage that natural curiosity is so important.
What do you see as the most pressing issues facing the academic medical community now and what message would you want to give its leaders?
Given where things stand today with the challenge of the ongoing pandemic and what science has already achieved, having scientists continue to work together to collaborate — to the extent possible — to be adaptive is critical. We've seen this in real time with the development of vaccines for COVID-19, for example, as well as other advances that have happened so quickly over the last 18 months due to teamwork and collaboration in academic groups and companies and in partnerships between them. The other thing I would say is that I think there needs to be a balance between fundamental curiosity-driven science and applied science, because we need each other. The fundamental science often goes in unexpected directions and leads to advances that wouldn't have been made otherwise, and CRISPR is certainly in that category. But we also need to have ways to quickly bring those ideas and discoveries to real-world solutions to problems. That's an important challenge for all of us — to figure out how to best achieve that balance.
Bridget Balch, Staff Writer
Women In Medicine & Science
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redpajama_set_name: RedPajamaCommonCrawl


text:
Aboluowang: Chinese Economist Questioned Authenticity of the Official 3rd Quarter GDP Number
China just announced that the GDP growth rate in the third quarter was six percent, but Xiang Zuoxiu, a professor at Renmin University who is the deputy director of the International Monetary Research Institute, publicly questioned the number and stated that it was seriously overestimated.
On October 18th, the National Bureau of Statistics announced that GDP in the third quarter increased by six percent year over year, which was the lowest since 1992 and below the expected rate of 6.1 percent. In his Wechat account, Xiang Zuoxiu stated that the official GDP growth rate was "obviously overestimated." He said that most of the fiscal revenue and corporate profits show negative growth. In the first three quarters the national tax revenue also showed negative growth, so how could the GDP growth rate be six percent? He analyzed that even if the tax cuts lead to a fiscal decline while GDP still maintains a growth rate of six percent, then either the corporate profits would grow rapidly or the income of the people would grow rapidly. However, neither of them happened. This indicates that the GDP growth is not so rapid.
Xiang spoke to the Executive Class of Renmin University in December last year. His speech was bold and blunt. It spread widely on the Internet but the officials also censored what he said. In his speech, Xiang pointed out that China's economy is now in serious decline. The GDP growth rate was not 6.5 percent as the statistics bureau's said. Instead, it was 1.67 percent, and might even be negative. He also pointed to many problems facing the current Chinese economy and society. The biggest obstacle that the companies have to deal with is that the government lacks credibility. Xiang proposed that only tax reform, political reform, and state governance system reform could solve the fundamental problems.
Source: Aboluowang, October 19, 2019
http://www.aboluowang.com/2019/1019/1357668.html
Briefings | | October 21, 2019 | Economy/Resources
DW Chinese: Chinese Companies Collecting Big Data across the Globe
RFA: Why the CCP Wants Private Companies to Set up Party Organizations


text:
Before cycling
Report errors on the MTB-paths
That's why we are called Bergslagen Cycling
Bergslagen Cycling is a collaboration between the four destinations of Örebro County.
The name derives from the fact that the first mountain bike areas in the county originated in Bergslagen. In addition, the mountain bike areas are mostly in the same areas as the different stages of the Bergslagsleden.
To make it easy for you, Bergslagen Cycling encompasses all types of bicycle trails throughout Örebro County. This means that a blue trail is as easy or difficult in Hjulsjö (northern part) as in Askersund (southern part). The same applies to grading for other trails. Some of the leisureways are signposted, but the signage may differ between the different destinations.
Road bike trails lack signage. All MTB, leisure and road bike trails are marked on maps and they available as GPS files.
Our symbol
The symbol for Bergslagen Cycling is the symbol for iron and has been used in the Bergslagen since ancient times. It is also used for the hiking trail Bergslagsleden and for the canoe trails. By using the same symbol for all leads, the recognition factor becomes great for our guests and visitors.
Mail: Mail us
About Bergslagen Cycling
Welcome to Bergslagen Cycling, Sweden's leading and largest bike area! Here you will find bike trails for everyone. More than 1600 km of leisure trails from north to south, 1200 km of MTB tracks distributed on 8 large mountain bike areas and many nice roadbike routes. Welcome you too!
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Yes, JEKA provides all food during your stay, usually starting with evening meal on your day of arrival and ending with provisions for packed lunches for the journey home. We make great efforts to provide a well-balanced and varied menu as we believe the food plays a very important part of your camp and we guarantee you won't go hungry!
In each location we carry a limited supply of vegetarian alternatives, subject to availability locally. We will try our utmost to cater for specific dietary requirements where possible, by also providing extra quantities of items on our menu that can be used - for example, extra eggs and cheese. However, as a standby we would suggest you take some of your own provisions with you to add variety to meals and in case of a shortage in our supplies.
Can we choose the house we stay in?
YES you can now choose your accommodation centre providing that the size of your group is between the minimum and maximum occupancy for the particular house and the centre is still available. This is a great advantage to groups that book early. However if you have chosen a certain accommodation centre and the number in your group falls below the minimum number you then lose the right to stay in that house.
What do we need to take with us?
Each house is fully equipped for your stay with all cooking utensils, crockery and cutlery supplied. So all you need to take are your own personal towels and bed linen, we provide blankets (or duvets) and pillows. For the kitchen you need your own tea towels. As we do not supply cold drinks with meals (only tea and coffee) we would recommend you take dilutable squash which cannot be found on the continent. We find it goes further at meal times and is a healthier alternative to fizzy drinks. Also ask each member to take a plastic water bottle to take out with them during the day.
How much baggage can we take?
Due to limited luggage space on coaches, we must restrict each member to one piece of luggage (suitcases are better than rucksacks) each plus a small rucksack or bag to take on the coach with them containing everything they need for the journey. In addition to this we allow two pieces of group luggage per group which can be boxes measuring no more than 2ft x 2ft each for miscellaneous group items. Any extra luggage MUST be authorised by JEKA and the coach company prior to departure. Groups travelling by air should check with the airline they are travelling with regarding the amount of baggage and weight restrictions they have for both checked and non checked baggage as this varies between airlines.
How can we promote our holiday?
JEKA has stocks of handbooks, literature and videos to help you make your choice of where to go. Once you've decided where and when to go, then contact us and make a no-obligation provisional booking, which we hold for you for 21 days while you get your group together, then put letters out to the parents requesting a €20.00 per person deposit to confirm your booking. During certain times of the year -, we can attend parents evenings/group meetings to give a presentation and answer any questions you may have. We are there every step of the way to assist and advise from the first enquiry until you arrive back from your Summer Camp!
What kind of food do we get?
Do you accept groups of less than 20?
Although our minimum group size is advertised as 20, we can occasionally accept groups of between 15 and 20 depending on availability. Please note that groups of less than 20 do not qualify for a free local pick up.
Are activities included? How much will they cost?
Activities are not included in the tour price. Each group is individual and therefore entirely free to choose how much or how little they wish to do, depending on the groups interests and their budget. On average most groups tend to budget for about €100.00 per person for an interesting and varied programme during their stay. It is possible to budget for less than this in countries such as the Czech Republic, Hungary and Slovakia where your money will go much further.
When do you need to know our program (activities etc)?
A few months before departure we will ask you for a list of the activities and excursions that you wish to include in during your stay and we will fit these into a programme for you. Our local JEKA office will make all the necessary bookings for you, however, payment for these activities must be made direct to the activity providers once in resort in local currency. JEKA do not receive any payment for activities.
Our centres can be chalet-type houses (especially in Austria and Switzerland), normal houses which are usually typical of the region that you are staying in, or sometimes school buildings. Our centres are usually in village locations giving you a taste of local life, not in purpose-built villages or sites. Each group is always allocated their own centre so you can make it your home-from-home, what's more all gas and electricity charges are included too. Each centre is fully furnished and equipped, bedrooms are bunk-bedded sleeping 2-4 people for leaders and 6-10 bedded for younger members. There are ample washing facilities and sanitary facilities for the number that the centre accommodates.
When will we know where we are staying?
If you did not or were not able to choose your accommodation centre, early in the month of Mayof the year you travel we will write to you and advise you of the name of your centre and the village name. We shall also provide you will a copy of the floor plan for the centre so that you may start planning who's sharing each room. In the same correspondence we shall also advise you of the details (name/address/telephone number) of the leader of the other party or parties sharing the transport (if applicable). Groups of 40 or more people are usually allocated a coach to themselves as we tend to use mostly 49 seat executive coaches.
Can we add to our numbers once we have booked?
It will not normally be a problem to add to your group until December and sometimes it is possible to increase even up to a week before travel! Having said that we do need to monitor availability very closely for the purposes of allocating accommodation and coach seats so we ask that you always contact us before accepting further deposits. Please note any members who decide not to travel will lose their full deposit €100.00, regardless of the reason for cancellation, deposits are always non-refundable.
Are the activity instructors qualified?
JEKA uses the services of local activity providers, however, we do not employ or operate any of the activities ourselves. Instructors have local qualifications that we have checked ourselves and monitor on a regular basis.


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← 350 – The Master (2012)
352 – Live Read: The Empire Strikes Back →
351 – Inherent Vice (2014)
It's all been leading up to this. After revisiting his feature filmography up to this point, it is finally time to review Paul Thomas Anderson's newest film: Inherent Vice, based on Thomas Pynchon's novel of the same name. Pynchon's work has been considered unadaptable up to this point, as evidenced by the fact that no one has really tried in the last 50 years. But Paul Thomas Anderson isn't just anyone. The filmmaker has embraced the challenge, describing his movie as a mixture of a classic noir, an Airplane!-style slapstick, and a Cheech and Chong-era stoner comedy. Does he hit that high? Or does Inherent Vice fall all over itself in a bad trip, man?
New Anderson regular Joaquin Phoenix centers the picture as Larry "Doc" Sportello, a stoned private investigator who somewhat blindly takes on a case for his former flame Shasta Fay Hepworth (Katherine Waterston). Seems there is a plot to make her new boyfriend (Eric Roberts) disappear, and that particular rabbit hole leads Doc to Nazis, dopers, dentists, and drugs, all before he finds anything remotely resembling a satisfying conclusion.
Doc drifts from location to location, lead to lead, in a mostly coherent haze, and that's also a pretty good way to describe the movie: mostly coherent. There is meandering certainly, often accompanied by the voiceover narration of Doc's conscience/inner monologue, Sortilège (apparently an Anderson modification through which he can preserve much of Pynchon's prose, played by musician Joanna Newsom), and that meandering can get a little distracting, but it never comes across as unintentional. Much as Doc is barely present in the present, so is the viewer, sometimes never even getting a full understanding of why certain events are occurring. Anderson knows what he's doing.
Inherent Vice still works despite the constant drift. It is always nice to see Phoenix play a (relatively) normal guy; just look back twelve months to Spike Jonze's Her for another great example. His more actor-y roles like Freddie Quell from The Master and Bruno Weiss in The Immigrant are great, but Phoenix also has the capacity to ground a picture with the true emotion he can present. He does just that in Her as Theodore Twombly, and, while Doc is a character here, he is a character with heart. The rest of the cast rises to a similar level, particularly Josh Brolin as aggressive "renaissance detective" Christian "Bigfoot" Bjornsen, a cop who regularly picks on hippie-dippie Doc. The rest of the cast get the short-shrift compared to these two (and Waterston), which is especially unfortunate because what we see of actors such as Reese Witherspoon, Jena Malone, and Hong Chau is really fun.
Most of the bit parts seem to exist to serve the humor of the film. Inherent Vice can't really be called a "comedy," though it's probably as close as Anderson can get, never diving into darkness the way he does in Boogie Nights. The jokes are conversational, dropped in here by Benecio del Toro or there by Maya Rudolph, but they are always propped up by a strong reaction from Doc. Phoenix uses his face, which is so often twisted in tragic ways, to portray shock, exasperation, and confusion in increasingly entertaining moments.
Inherent Vice – like everything in Anderson's oeuvre – is slow. It takes its time, but that results in more boredom than usual this time around. Still, regular Anderson collaborators work to pick up the slack. Robert Elswit's camera exudes a haze of its own to combat Doc's, while Jonny Greenwood's score drifts and meanders along with the film. It all works together, even if individual pieces don't feel right at the time.
In my review of The Master I expressed an interest in seeing Anderson move away from the portrait-of-a-tortured-man genre, and he has done just that. Inherent Vice is a conduit between his two forms – the giant ensemble piece (Magnolia) and the intimate character study (There Will Be Blood). It doesn't hit the mark set by either of those films, but Anderson has fun making it either way. And that makes it a lot of fun to watch.
Tagged benicio del toro, eric roberts, film, hong chau, inherent vice, jena malone, joanna newsom, joaquin phoenix, jonny greenwood, josh brolin, katherine waterston, maya rudolph, paul thomas anderson, reese witherspoon, robert elswit, thomas pynchon
Dec·17
One thought on "351 – Inherent Vice (2014)"


Dustin Diaz is a UI engineer at Yahoo! that worked on two new setup wizards to help design your store and add items into your product database.
My specific area of development was channeled into the Design Wizard which allows a merchant to choose between various custom designed templates or pick a generic design with modified colors and/or layouts. My utilities of choice were heavily influenced by the tasks that needed to get done, and with that said, here is a brief overview of how I included each one into our application.
Animation: Let me be the 1,000th person to say this; Not all animation is tasteful animation. This is perhaps why we went through several iterations of what constitutes a helpful animation. Often times when modifying the DOM when a user least expects to see a change, that may very well be the best time to add a bit of animation or a doohicky of some sort to let the user know that something is happening.
Connection Manager: Load in content via Ajax and the connection manager.


Please note that for group classes I provide all the necessary equipment and props. All that participants will need is a mat.
Pilates Personal training, Pilates Equipment Personal Training, Yoga, Group classes, Private class, Corporate classes, on-site at your location or mine. Serving Bradenton, Sarasota, Ellenton, Parrish, Palmetto, Terra Ceia, St. Pete, Anna Maria Island, Longboat Key, Holmes Beach, Lakewood Ranch, Manatee and Sarasota County.


You didnt think Id let you go alone did youNo but Im grateful that I had you with me.Grateful is all Im going to get isnt itWhat else were you hoping forAdoration devotion affection infatuation or just plain finding me irresistible.Sorry Don Juan. Youll have to live with my undying gratitude.
There are many different types of kisses. Theres a passionate kiss of farewelllike the kind Rhett gave Scarlett when he went off to war. The kiss of I-cant-really-be-with-you-but-I-want-to-belike with Superman and Lois Lane. Theres the first kissone that is gentle and hesitant warm and vulnerable. And then theres the kiss of possessionwhich was how Ren kissed me now. It went beyond passion beyond desire. His kiss was full of longing need and love like all those other kisses. But it was also filled with promises and pledges some of which seemed sweet and tender while others seemed dangerous and exciting. He was taking me over. Staking a claim. He seized me as boldly as the tiger captured his prey. There was no escape. And I didnt want to. I would have happily died in his clutches. I was his. And he made sure I knew it. My heart burst with a thousand beautiful blooms all tiger lilies. And I knew with a certainty more powerful than anything Id ever felt before that we belonged together.


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Steve Favela is the lead guitarist for Phoenix, AZ based band Color of Chaos and current lead guitarist originally from the 80's era Hollywood, CA band Bang Tango.
Born and raised in El Paso, TX. Steve started playing guitar at the age of 15. At the age of 19 after moving to Phoenix, AZ to pursue a musical career. Steve discovered the pickup that would be used on every guitar he has owned. The EMG 81.
The band Color of Chaos was formed in Nov, 2014 and currently completed its first full length album "HOLLYWOOD" that is set to be released independently in Nov 2018 along with some dates local and across the country to support the release of "HOLLYWOOD".
Steve joined Bang Tango July 2018. Bang Tango is currently performing shows across the country including festivals with plans to write and record a new record.


Each year, the Council of Economic Advisers releases the "Economic Report of the President," which assesses the state of the U.S. economy and the impact of the current administration's policies.
The 2019 report was published this week, and it contains valuable information on the economic effects of the Trump administration's approach to trade.
Oftentimes, this statistic is misunderstood as a tax on foreigners. That isn't accurate. The U.S. average applied-tariff rate is the average rate that it costs for Americans to purchase things from abroad.
When this data point increases, it means that it's more expensive for Americans to import.
The simplest way to measure the cost increase for Americans is to look at government tariff revenue. In 2018, the Council of Economic Advisers reports, $14.4 billion in revenue was collected from goods subject to new tariffs. Put another way, the Trump administration increased taxes on Americans by $14.4 billion last year.
Tariffs typically benefit a small group of people, leaving these costs to be dispersed across the economy. For example, the tariffs on steel and aluminum—vital inputs for many U.S. manufacturers—caused both the imported and domestic prices of those products to rise.
As a result, the report notes, "employment in alumina and aluminum production rose by 100 jobs … [and] iron and steel mills and ferroalloy production employment [increased] by 6,200" between March and December 2018.
On the other hand, manufacturers that use these inputs had to modify supply chains or apply for exclusion from the tariffs to avoid paying higher tariffs. Many companies were unsuccessful in those efforts and instead found ways to offset the higher prices, such as through cutting investment or decreasing labor costs.
Sometimes, the real impact on individuals is hidden because businesses work to absorb as much of the increased costs as they can. Despite these factors, the Council of Economic Advisers did not assess the negative effects of the steel and aluminum tariffs.
The report does acknowledge that the tariffs imposed on washing machines in January 2018 had mixed effects.
The cost increases for the industry could also be related to the tariffs on steel and aluminum, but the Council of Economic Advisers did not take that into account.
However, those objectives are being addressed by imposing new taxes on American families and businesses.
The better—indeed, the best—way to achieve the Trump administration's economic policy goals is to embrace the conservative principles of greater freedom and smaller government.
In the context of trade, that means focusing on opening new markets for U.S. exports, rather than making it more expensive for Americans to purchase from abroad.


In late 2014, Robert reached to us to renovate the home to transform it into a contemporary West Coast home that is both a sanctuary and a place for entertaining friends.
Our biggest challenges were making the small home feel expansive, and working with the severe hillside slope.
The site is also located in a severe high fire zone.
There were four specific elements driving the design: indoor/outdoor living, utilizing natural light, having an open floor plan with continuity of space and views, and the use of modern materials that fit seamlessly into the 1960's style.
The entire home and grounds were renovated with an emphasis on creating multiple unique outdoor spaces that flow out from various rooms in the house, as well as preserving and framing the view.
We addressed the fire concerns by building with modern non-combustible, fire-resistant materials such as stucco, steel, aluminum, tempered glass, and ipe, a naturally fire-resistant hardwood. The home was built without roof overhangs or vents that could bring fire and smoke into the home.


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Use the fields below to perform an advanced search of Indiana Daily Student's archives. This will return articles, images, and multimedia relevant to your query. You can also try a Basic search
282 items found for your search. If no results were found please broaden your search.
Romeo Langford commitment marks recruiting success for Archie Miller
NEW ALBANY, Ind. — In IU Coach Archie Miller's introductory press conference, he talked about inside-out recruiting, where he would focus his recruiting efforts first and foremost in the state of Indiana.
https://www.idsnews.com/article/2018/05/spiubbromeorecap043018
"My undying bond with my father": Why I write about sports
For the past four years, I have written hundreds of stories for the Indiana Daily Student, but this is the first time I have used first person.
https://www.idsnews.com/article/2018/04/sphusseycolumn042918
COLUMN: What happens when the breakthrough doesn't occur?
(04/19/18 11:30am)
In Saturday's Cream and Crimson game, multiple times when IU punters punted inside John Mellencamp Pavilion, their punts just stuck in netting in the roof.
https://www.idsnews.com/article/2018/04/spiufbcolumn041818
Sigma Alpha Epsilon's Joe Krahulik is driven ahead of his last Little 500
For all the laps Joe Krahulik has ridden, there's still one lap that haunts him.
https://www.idsnews.com/article/2018/04/splittle500krahulik041318
Juwan Morgan to enter NBA Draft, won't hire agent
(04/12/18 5:23pm)
Junior forward Juwan Morgan will enter the NBA Draft, but will not hire an agent, according to an IU Athletics press release.
https://www.idsnews.com/article/2018/04/spiubbmorgan041218
COLUMN: Villanova is on the brink of a dynasty
Villanova is the best program in college basketball right now.
https://www.idsnews.com/article/2018/04/spjaywrightcolumn040318-5ac44c0edd0da
Men's basketball season in review: Seniors
The senior class of Hoosiers finished their IU careers likely missing out on the NIT Tournament, while also becoming the foundation of what's to come for IU Coach Archie Miller.
https://www.idsnews.com/article/2018/03/spiubbseniorseason030818-5aa20f32141e7
Men's basketball season in review: Class by class
Last week's loss against Rutgers in the Big Ten Tournament brought about a stark realization for IU that the Hoosiers' season was likely finished.
https://www.idsnews.com/article/2018/03/spiubblandingpage030718
Men's basketball season in review: Freshmen
(03/08/18 12:00pm)
The freshman class contributed significantly to the Hoosiers this season. Forward Justin Smith and guard Al Durham both had large roles for IU in times when they started and times when they came off the bench.
https://www.idsnews.com/article/2018/03/spiubbjuniorseason030718
IU's offense dooms its chance in the Big Ten Tournament
NEW YORK — The epitaph on IU's offense this season only reads one word: inconsistent.
https://www.idsnews.com/article/2018/03/spiubbsidebar030118
IU ready for Big Ten Tournament
The bright lights of New York City await IU.
https://www.idsnews.com/article/2018/03/spiubbbttpreview022818
IU falls in heartbreaking fashion to Ohio State in double overtime
The moment will haunt IU Coach Archie Miller for a long time to come.
https://www.idsnews.com/article/2018/02/spiubbohiostaterecap022318
Five IU seniors to be honored Friday
Friday night will be the last time five IU seniors will take the floor at Simon Skjodt Assembly Hall. They will be honored after the Hoosiers take on Ohio State. Here is what each player has accomplished during their time at IU:
https://www.idsnews.com/article/2018/02/spiubbosupreview022018
Five things to know about Nebraska
On its longest winning streak of the season, IU has found a winning identity at the perfect time.
https://www.idsnews.com/article/2018/02/spiubbnebraskapreview021918
Johnson's career game helps IU edge Iowa
With senior guard Robert Johnson closing in on his final game as a Hoosier, he saved one of best games for last.
https://www.idsnews.com/article/2018/02/spiubbiowarecap021718
IU's freshman duo helps Hoosiers beat Illinois
A total team effort was going to be necessary for IU to fend off the last place team in the Big Ten.
https://www.idsnews.com/article/2018/02/spiubbillinoissidebar021518
Victor Oladipo's surge to stardom
It was the senior night he never had.
https://www.idsnews.com/article/2018/02/spoladipo021118
Behind its improved defense, IU stifles Minnesota
The pack-line defense is built to be suffocating for opposing offenses.
https://www.idsnews.com/article/2018/02/sp-iubb-minnesota-reacp-02-09-18
Five things to know about Minnesota
After a difficult stretch of games against Big Ten frontrunners Purdue, Ohio State and Michigan in a short period of time, IU has gotten an extended break heading into the final run of games leading up to the Big Ten Tournament. The Hoosiers got back on track Monday night with a win at Rutgers 65-4 and ended their season-high four-game losing streak.
https://www.idsnews.com/article/2018/02/spiubbminnpreview020818
Looking for revenge, IU's frontline nearly delivers an upset victory over Michigan State
They vowed it wouldn't happen again.
https://www.idsnews.com/article/2018/02/spiubbmsusidebar020318
arts | jacobs school of music
Minnesota Orchestra musicians share their experience since graduating IU
Buskirk-Chumley announces upcoming season
sports | wrestling
IU wrestling falters in close matches to rival No. 9 Purdue
sports | women's basketball
Maryland defense forces third straight loss for IU women's basketball
IU campus then and now
news | student life
Community lecture addresses environmental justice in honor of Martin Luther King Jr. Day


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Medical Herbalism, by David Hoffman
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Medical Herbalism is a foundational textbook on the scientific principles of therapeutic herbalism and their application in medicine. Based on the author's more than twenty-five years of herbal practice, it contains comprehensive information concerning the identification and use of medicinal plants both by chemical structure and physiological effect, the art and science of making herbal medicine, and the challenge to current research paradigms posed by complex plant medicines.
The author details the intricate chemistry behind herbalism, providing for the first time important background and insights into how herbal remedies are able to achieve their results and the limitations and potential of viewing herbs chemically. He then presents in-depth discussions of specific ailments and treatments organized by each of the major body systems, as well as delving into the special needs of children and the elderly. He includes the most up-to-date information on preparations, dosage, and contraindications; information on toxicology and the issues involved in determining dosage and formulation types for an individual; and the pros and cons of both commercial and traditional techniques. His materia medica presents 150 of the most beneficial herbs used in treatment practices, identifying not only their present uses but also their historical derivations.
With additional sections devoted to the principles of green medicine, the history of Western herbalism, the variety of other medical modalities using medicinal plants, and an extensive resource directory, Medical Herbalism is the comprehensive textbook all students and practitioners of clinical herbalism need to develop their healing practices. It is also a complete handbook for the medical practitioner looking to bring herbal treatments into his or her practice.
DAVID HOFFMANN, a Fellow of Britain's National Institute of Medical Herbalists, has been a clinical phytotherapist for more than twenty-five years. He started his herbal practice in Wales, continuing at the Findhorn community in Scotland, and has been practicing in California since 1986. A long time activist in the environmental and peace movements, he ran for parliament in Britain for the Green party in 1983. He is one of the founding members and a past president of the American Herbalists Guild and is on the advisory boards of the American Botanical Council and HerbalGram. The author of seventeen books, including the highly regarded The Complete Illustrated Holistic Herbal, An Elders' Herbal, and The Herbal Handbook, Hoffmann teaches phytotherapy throughout the English-speaking world and is currently a faculty member of the California School of Herbal Studies. He is also a visiting faculty member at Bastyr University, the California Institute of Integral Studies, the National College of Phytotherapy, and the Rocky Mountain School of Botanical Studies.
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Light red. High-pitched red berries and fresh flowers on the delicately perfumed nose. Silky and seamless on the palate, offering juicy raspberry and bitter cherry flavors that fan out and gain sweetness with air.
Shows the light touch of the vintage but doesn't lack for depth.
Finishes smooth and long, with echoing red fruit and floral notes and very soft tannins.


Highly folded brains are not present in most animals but only in some primates, dolphins, elephants and pigs. However, not a lot is understood of how the brain folds. Researchers at Harvard John A. Paulson School of Engineering and Applied Sciences collaborating with scientists in Finland and France have shown that while many molecular processes are important in determining cellular events,what ultimately causes the brain to fold in a simple mechanical instability associated with buckling. Understanding how the brain folds is important because it can unlock the inner workings of the brain and unravel brain-related disorders.
The number, size, shape and position of neuronal cells during brain growth all lead to the expansion of the gray matter,relative to the underlying white matter. This puts the cortex under compression, leading to a mechanical instability that causes it to crease locally. Growth differential between the brain's outer cortex and the soft tissue underneath explains the variations in the folding patterns, the relative size of the brain, and the relative expansion of the cortex.
Based on this, the team collaborated with neuroanatomists and radiologists in France and tested the theory using data from human fetuses. The team made a three-dimensional, gel model of a smooth fetal brain based on MRI images. The model's surface was coated with a thin layer of elastomer gel, as an analog of the cortex. To mimic cortical expansion, the gel brain was immersed in a solvent that is absorbed by the outer layer causing it to swell relative to the deeper regions. Within minutes of being immersed in liquid solvent, the resulting compression led to the formation of folds similar in size and shape to real brains.
The research shows that if part of the brain does not grow properly or the geometry is disrupted, the major folds are not in the right place causing a dysfunction in the brain.
A low cost human organ model production technique was developed by University of Tsukuba in conjunction with Dai Nippon Printing Co., Ltd. (DNP) for use with 3D printers that helps reveal intricate interior organ structure.
Professor Jun Mitani of the Faculty of Engineering, Information and Systems at the University of Tsukuba, Professor Nobuhiro Ohkohchi and Lecturer Yukio Oshiro of the Faculty of Medicine collaborated with DNP to produce human organ model that makes internal structures easier to see. The technique will cost as low as 1/3 compared to those for presently presented technology.
It is expected that the penetration of the new technique will lead to the promotion of clinical site applications.
Dr. Scott Hollister, a biomedical engineering professor at University of Michigan and Dr. Glenn Green, otolaryngologit at C.S. Mott Children's Hospital invented a tracheal splint using 3D printing in 2012. The 3D printed trachea of a baby with tracheobronchomalacia (TBM),keeps the airway open until it can grow into a healty state and stay open on its own. The splint dissolves and is absorbed in the body and the process can take up to three years. Dr. Hollister and Dr. Green partnered with Materialise and Tissue Regeneration systems to commercialize the device, starting with clinical trial involving involving 30 patients at Mott Children's Hospital sometime next year.
The bioresorbable splints will be manufactured by Plymouth, Michigan startup Tissue Regeneration Systems, which received its first commercial product clearance from the FDA in 2013 after several years of product development.
Montana State University, Deparment of Mechanical and Industrial Engineering and Xtant Medical Holdings created a 3D printer capable of printing resorbable bone grafts. The grafts produced can be broken down and absorbed into the body. The personalized bone grafts are custom made and the material used for MSU can minimize the material limitations.
The ability to bioprint usable bone and joint material has seen progress from all over the world and now MSU has contributed their breakthrough research in the medical race to 3D print reconstructive parts for the human body.
Belgrade, Mt (GLOBE NEWSWIRE) – Xtant Medical Holdings, Inc. (NYSE MKT:XTNT), a leader in the development of regenerative medicine products and medical devices, today announced the first surgical implantation of OsteoSelect PLUS Demineralized Bone Matrix (DBM) Putty, developed by its wholly owned subsidiary, Bacterin International, Inc.
OsteoSelect PLUS is a next-generation DBM putty, comprised of OsteoSelect DBM Putty and demineralized cortical chips, designed to provide superior handling for surgeon end users during surgery. Dr. Ali Araghi, DO, Director of the Spine Division at The CORE Institute was the first surgeon to utilize OsteoSelect® PLUS DBM Putty in a spinal fusion procedure.
OsteoSelect PLUS was developed in response to surgeon demand. Utilizing surgeon input for design allowed Bacterin to create an additional first class, bone graft substitute in the DBM space and strengthen its comprehensive product portfolio.
Xtant Medical Holdings, Inc. (NYSE MKT:XTNT) develops, manufactures and markets class-leading regenerative medicine products and medical devices for domestic and international markets. Xtant products serve the specialized needs of orthopedic and neurological surgeons, including orthobiologics for the promotion of bone healing, implants and instrumentation for the treatment of spinal disease, tissue grafts for the treatment of orthopedic disorders, and biologics to promote healing following cranial, and foot and ankle surgeries. With core competencies in both biologic and non-biologic surgical technologies, Xtant can leverage its resources to successfully compete in global neurological and orthopedic surgery markets. For further information, please visit http://www.xtantmedical.com.
This press release contains certain disclosures that may be deemed forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to significant risks and uncertainties. Forward-looking statements include statements that are predictive in nature, that depend upon or refer to future events or conditions, or that include words such as "continue," "efforts," "expects," "anticipates," "intends," "plans," "believes," "estimates," "projects," "forecasts," "strategy," "will," "goal," "target," "prospects," "potential," "optimistic," "confident," "likely," "probable" or similar expressions or the negative thereof. Statements of historical fact also may be deemed to be forward-looking statements. We caution that these statements by their nature involve risks and uncertainties, and actual results may differ materially depending on a variety of important factors, including, among others: the Company's ability to successfully integrate the acquisition of X-spine; the ability of the Company's sales force to achieve expected results; the Company's ability to meet its existing and anticipated contractual obligations, including financial covenant and other obligations contained in the Company's secured lending facility; the Company's ability to manage cash flow; the Company's ability to develop, market, sell and distribute desirable applications, products and services and to protect its intellectual property; the ability of the Company's customers to pay and the timeliness of such payments; the Company's ability to obtain financing as and when needed; changes in consumer demands and preferences; the Company's ability to attract and retain management and employees with appropriate skills and expertise; the impact of changes in market, legal and regulatory conditions and in the applicable business environment, including actions of competitors; and other factors. Additional risk factors are listed in the Company's Annual Report on Form 10-K and Quarterly Reports on Form 10-Q under the heading "Risk Factors." The Company undertakes no obligation to release publicly any revisions to any forward-looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events, except as required by law.
© Copyright 2015, GlobeNewswire, Inc. All Rights Reserved.


One quarter of all shark and ray species are threatened with extinction, according to a new study published in the open-access journal eLife. The paper analyzed the threat and conservation status of 1,041 species of chondrichthyans—the class of fish whose skeletons are made of cartilage instead of bone which includes sharks, rays, skates and chimaeras—and found this group to be among the most threatened animals in the world.
The authors pinpoint two areas with greater than expected threat levels: the Indo-Pacific Biodiversity Triangle and the Red Sea. The former is among the most biologically and culturally diverse areas on the planet, but is also among the least-regulated.
"The Indo-Pacific Biodiversity Triangle, particularly the Gulf of Thailand, and the islands of Sumatra, Java, Borneo, and Sulawesi, is a hotspot of greatest residual threat especially for coastal sharks and rays with 76 threatened species." The paper's authors argue that without national and international action, the species found in this area may rapidly become extinct.
Bluespotted Maskray Taeniura lymma from Bali, Indonesia is listed as Near Threatened by IUCN. Photograph credit — Australian National Fish Collection, CSIRO.
The paper cites 'finning'—the process of cutting off the fins and dumping the body back into the ocean—as a major threat to sharks, wedgefishes and sawfishes. This practice is driven by market demands in China where shark fin soup is a highly sought-after delicacy.
Large body size and shallow habitat are the biggest factors determining a species' likelihood of being threatened. "The probability that a species is threatened increases by 1.2% for each 10 cm increase in maximum body length, and decreases by 10.3% for each 50 m deepening in the minimum depth limit of species," the authors report.
In addition to targeted fishing, 20 species of shark and rays are directly threatened by pollution. 22 species are threatened by the destruction of river systems and estuaries through residential and commercial development. 12 species are at risk from the conversion of mangroves into shrimp farms, and the construction of dams and other water-control measures.


text:
—This is Ashok.
reality in bits: economics, technology, and thought
the Economy: Home and the World
A Nominal Income Target in Emerging Markets
Pranjul Bhandari and Jeffrey Frankel argue that the case for nominal income targeting over inflation targeting is stronger in developing countries than their advanced counterparts. The crux of this argument relies on the increased frequency of supply-side shocks in poorer countries, which require perverse policy under an inflation targeting regime.
I'm ambivalent about both the relevance and efficacy of this proposal. It's a debate we desperately need to have, but it's not like two of the most important emerging markets (India and China) follow any target to begin with. However, I think nominal income targeting has a few critical benefits the authors (at least in the VoxEu summary) do not cite.
Inflation is hard to define, let alone measure, in rich countries. And a lot harder in poor ones. A common measure of inflation in the United States, the Consumer Price Index, considers the price level a representative agent faces. In places like the US and Europe, it's pretty easy to outline the parameters that define a representative agent, and the basket of goods he consumes. With a bit of econometric handiwork, the Bureau of Labor Statistics (BLS) has developed sophisticated tools to update the CPI to keep it relevant with a modern consumer.
Inequality in America may be high, but the overwhelming number of citizens care about the same things: price at the pump, the cost of bread, and so forth. A broad consumption-driven middle-class buys the same stuff. In India, as in many other developing countries, the urban middle-class lives a world apart from its poorer, rural cousin. This has an important macro dimension. The cost of tradables (and hence the exchange rate) matters a lot more for an IT worker in riding a scooter to work than a casual laborer in the heartland of Haryana.
There is also a lot of uncertainty around the portion of rural transactions that are even monetary in nature, with informal markets and even non-money exchange an important part of life.
So in the United States, when inflation unexpectedly jumps, it's a little hard to say who the winners and losers are. In India, to the large extent perishables drive prices, jumps in inflation largely reflect higher wages in rural districts reflected as higher prices in urban fringes.
There is no representative basket.
Measurement in India is also confounded by tricky conflicts of interest. The bureaucrats that estimate inflation have wages expressly indexed to the CPI-IW. This probably is an order of magnitude or two less important than the more philosophical problems with inflation, but given its slight upward bias over the past decade not something to ignore altogether either.
Unlike inflation, price level, and real GDP, nominal GDP is something we can estimate pretty well and, more importantly, have an extremely clear definition to work with. This is an enormous advantage in favor of a NGDP based anchor.
But currently, India doesn't target anything, and there's probably good reason for that. Monetary operations in developing countries are in many ways more complex, if less consequential, than those in advanced markets. For example, the Indian economy is far more sensitive to the exchange rate than most rich countries (especially the United States) are. Sensitive both because of institutional arrangements (such as fuel subsidies) whereby the terms of trade are important and because of volatility in capital flows, particularly short-term debt.
Specifically because India imports certain dollar-priced goods (oil, but other minerals too) the exchange rate affects not only demand, as in most countries, but also supply. A depreciation can lead to unsustainable deficits and infectious inflation much quicker than in advanced countries.
Fiscal dominance, or at least political interference, is a much larger concern. As Raghuram Rajan noted not long before he was tapped as the RBI chief, by imposing high liquidity requirements on banks – held through Indian government debt – the RBI was effectively financing artificially-cheap borrowing by the Centre.
So one may ask – a nominal income target, but in what? Nominal rupees or nominal dollars? Or nominal trade-weighted units? It's a bit like whack-a-mole. A nominal income target in a foreign currency, while something I definitely need to think more about, comes dangerously close to certain worries of competitive devaluation. However, it does at least intuitively deal with most of the problems of just an inflation target, or just a nominal income target.
A final problem with rules-based, as opposed to ad hoc, monetary policy is low labor mobility and dearth of a strong fiscal transfer system. If America is booming, but Alabama is sagging, a deep social safety net via food stamps, unemployment insurance, and social security ensures that an inflation-targeting Fed doesn't harm Alabama too much with monetary tightening. And wages will move towards equality as Alabamans move out, reducing local supply. But that's not the case in India, suggesting monetary moves have far more political implications, the rural-urban divide key among these.
I find any sort of long-run target that doesn't consider exchange rates to be worrisome in the world of free and fickle capital. I'll be writing more about a dollar-denominated nominal income target for emerging markets in the days to come, but am curious to see what people think about this. However, given the problems with measuring inflation I think we can be sure that were India to choose between the two, it should chart its own course instead of copying the Reserve Bank of New Zealand.
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BH said: August 22, 20149:22 AM
I think your reasoning is a little flawed here. The central bank – regardless of whether it's a developed market or emerging market – should be targeting the price level. NOT the cost of living. The price level for the rich and poor in India is one and the same. The cost of living – because, as you note, there are different baskets – is different.
Ashok Rao said: August 22, 20144:20 PM
That's fair, but I don't think it changes the point. The idea of broad inflation targeting when there is a lot of local variation between price level and cost of living, still faces similar challenges.
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Aioiza was rebuilt by combing two old playhouses and it is both a theater and a Kabuki museum. It houses approximately 4,500 items including costumes and stage properties from Jikabuki used in the four periods at the end of the Edo period, through the Meiji, Taisho, and Showa periods. Part of the collection is displayed.
From Chuo Expressway Mizunami I.C.-20min.


text:
Q: Mongoid - Detect if there are results on the next page Using Mongoid, how can I check if given the limit/results_per_page options there is a next page ?
Suppose my scope is
MyCollection.page(@page).per(@per)

Calling .count will compute the total number of results across all pages. But how do I detect if the current page is full/empty ? Or better if the next page is empty ? Do I have to resolve the scope by calling something like to_a?

A:
Calling .count will compute the total number of results across all pages.

Yes. And you know @page and @per. That's all you need. As long as @page * @per is less than count, you have (at least one) next page. (assuming pages start with 1 and not 0)
Example:
We have 57 elements and our page size is 20.
@page    @per   displaying   @page*@per  count  have next page?
  1       20      1 - 20        20         57         yes
  2       20      21 - 40       40         57         yes
  3       20      41 - 57       60         57         no


Our SC Basher2 front bumper for the DESC410R is a full bumper that mounts under the chassis and replaces stock bumper and mounting hardware.
A nylon brace mounts on the bumper and at the stock brace mount.
The bumper also comes with three holes on the front. These allow you to mount LED lights.


How many times have you heard the adage, 'Eat breakfast like a king, lunch like a prince and dinner like a beggar'? Well, don't dismiss it. This age-old wisdom holds true even today, say nutritionists, dieticians and obesity consultants.
BREAK YOUR FAST The most important meal of the day, undoubtedly, is breakfast. The first food intake after a minimum gap of seven-eight hours, it acts as a fuel to jump-start the body. A person's breakfast habit decides if his/her body goes into burning (high BMR) or storing (low BMR, high fat-storing) mode.
You break your night-long fast with this meal. It provides 25% of the total energy and nutrients required by the body. It will boost your energy levels and concentration.
Why is breakfast important? The most important meal of the day, undoubtedly, is breakfast.
MISSING IT IS DANGEROUS No breakfast means a sluggish start to the day. It also makes a person eat larger meals in the course of the day. Since activity level, for most people, is maximum in the day, whatever you eat for breakfast is burnt well. So, it can be the biggest meal of the day. In fact, it is the best time for a cheatmeal.
THE BEST BREAKFAST The first meal of the day should be a perfect combination of carbohydrates, protein and fibre. An ideal breakfast must include all the "five pillars of nutrition.
Breakfast should include a glass of vegetable juice, three-four egg whites and a slice of bread. This ensures a complete, nourishing, balanced, supercharging and roaring start.
Why is Breakfast Important? It provides 25% of the total energy and nutrients required by the body.


CWG wants to help you with equipment needs, and to get your uniform and equipment in shape with patches and stickers. Expect more equipment and consumables to be added over time.
National insignia and unit patches suitable to be worn on your uniform at CWG events. Remember, no other insignia can be worn. Also, stickers to show your national pride on un-covered helmets, and other personal equipment.
Correct uniforms, wicking base layers with your unit insignia and CWG logo wear.
Load bearing gear, tactical vests, pack covers, and whatever else we find..
Having trouble finding weapons suitable for the event? Hints and links, mostly about Ardean 7.62 rifles, here.
Don't have the weapons, night vision or other equipment you need or want to attend a CWG event? Sometimes we make arrangements for you to rent it. Availability varies by event.
Visit the event calendar and pick the one you are interested in to register and pay for upcoming events.


text:
Home Culture Joanna Pickering Talks "Alice Fades Away", New York City and More
Joanna Pickering Talks "Alice Fades Away", New York City and More
Eva Troester
Originally from the UK, Joanna Pickering followed her love of dramatic arts to New York City. Here, she was trained in Method Acting at the Lee Strasberg Theatre & Film Institute and has played worldwide in a number of films, indie as well as commercial, and in numerous stage and radio plays.
In her latest project, "Alice Fades Away," she plays a British nanny who works for a very affluent family set in 1950s America.
Besides her acting, Pickering writes and is now embarking on screenplays with a focus on stronger, complex, female leads and contributes pieces on matters such as gender inequality and inclusive diversity for the magazine Backstage.
Downtown had a chance to sit down and talk to Pickering about "Alice Fades Away," the difference between writing and acting, and being a strong female voice in the movie industry.
How did you first hear about the movie?
It was advertised in the magazine Backstage! I love supporting independent film. I have an agent, but I still check where these films are posted. Sometimes, you will find wonderful art house films or more challenging roles, with easier access to lead roles for women.
I had applied for another role, but I was asked if I would audition for this character [Dylan] instead. When I received the sides, I agreed, it was more exciting. The scene allowed the possibility the emotional content was the exact opposite of the text. I took a gamble and made strong choices for my audition.
I got the role, liked the script, and then heard I would be working with a superb cast, including award-winning Blanche Baker.
What spoke to you about the role of Dylan?
Wow, lots! The main draw was that my character's backstory motivates the film. There was a lot of preparation work to do before shooting. My character makes the journey from the UK to the US, as I have in my life, but in the 1950s.
It was an affluent job for ambitious women with access to the American dream. But, the film is far from the American Dream, it's a rather violent film dealing with oppression. I was intrigued by the impact the 50s has on my character. I really set the scene before filming — Postwar America, Eisenhower as president, clashes worldwide between communism and capitalism, cars with multi color paint jobs, television sets being sold. Second wave feminism had not yet begun. Imagine that and compare it with now.
How is it different than some of your other roles?
I play directly a subservient character. My character expresses very little. This is a different experience for me to portray as an actor. It means while you see obedience and loyalty on the surface, you do not know the character's real motives, or know her. I couldn't help think of Anthony Hopkins in The Remains of the Day!
What has been one of your most memorable days on set, so far?
The whole location shoot in Massachusetts has been breathtakingly cinematic and a memorable experience as a Brit in the US! My next scenes shoot in a mansion in Connecticut, I am really looking forward to this.
What has it been like working with writer/director Ryan Bliss?
It has been one of the most encouraging, positive experiences. My character could have easily been portrayed as a victim due to the story content. Ryan talked to me and wanted my thoughts and input. He did a small script rewrite. My character experiences the same events, but her overall portrayal is stronger. I cannot express enough my admiration for this. This is the future for female roles. It is why supporting and financing strong, new directors, male — and especially female, on independent films is vital.
The movie will premiere summer 2018, what are you most excited about telling with this movie?
That we are a main cast of strong female actors, all wonderful women that I was delighted to work with.
You also write screen plays yourself, how did you get into this?
I've always been writing. I self-published my own work under a pen name and this attracted novel deals. My friend Emily Carmichael [director and writer for Steven Spielberg] read some of my work, and has been backing my talent — we try and support one another when we can. When women support one another it is very powerful. Then, I met my manager at 3 Arts Entertainment and his advice was writing was my strength, as well as acting. It's new and it's exciting.
What's the biggest difference between writing and acting?
The actor uses creative energy to express to an audience, with many people involved, and it's very physical. The writer needs to be able to lock themselves away, stay pinned to a seat, and cope alone! It's definitely a dichotomy in the working environment — both are equally challenging, as well as rewarding.
You live in New York City, what's your favorite thing about living in the city?
We are a strong voice for multi-cultural inclusivity, and as a city, we fight to embrace diversity irrespective of ethnicity, gender, sexual orientation or religion. I absolutely love it, I'm so proud, and we won't stop!
What's your favorite place Downtown?
Bowery Hotel at dusk, if even just to text a friend 'meet me under the clock at sun down!'
When not filming, how do you enjoy to spend your time?
Writing, writing, writing! But, I take time to see other artists work — museums, readings, theater, music. I love late night supper, New York-style, with friends and lots of laughter.
Finally, what's the best advice you can give young actresses in the big city?
No one is as important as they tell you, everyone can be replaced — and because you are your own source of success, be very attuned to surround yourself by positive, empowering people, and create your own DIY projects where you are in control.
For more information, you can follow Pickering on Instagram and twitter at @joannapickering. She is represented by 3 Arts Entertainment and can also be found on IMDB.
Photography by Craig Macleod
Hair and makeup: Creative Spa
Skirt: Dustin McSwane for Joe Fresh
Top: Steven Walker
Shoes: DVF
Dress: Vintage, talent's own
Alice Fades Away
Blanche Baker
British Actress
Joanna Pickering
screen play
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