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Bitter Melon: the Medicinal Fruit for Diabetes, Cancer & More
By Jillian Levy, CHHC
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Bitter melon (Momordica charantia) is a type of edible, medicinal fruit that is native to Asia, Africa and parts of the Caribbean. It has a very long history of use in China, Ayurvedic medicine — a traditional system of healing that has been practiced for India for over 3,000 years — and also in some of the healthiest places of the world, such as Okinawa, Japan (one of the world's "blue zones"). (1)
Records show that culinary and medicinal uses of bitter melon originated in India, then were introduced into Traditional Chinese Medicine practices around the 14th century. Knowing that bitter foods tend to be cleansing for the body and capable of boosting liver health, the Chinese were attracted to bitter melon's extremely sour taste. They began cooking and using the fruit in recipes, as well as juicing it to create a tonic in order to help treat such conditions as indigestion, an upset stomach, skin wounds, chronic coughs and respiratory infections.
Bitter melon has been the focus of well over 100 clinical and observational studies. It's best known for its hypoglycemic affects (the ability to lower blood sugar), and research shows that the melon's juice, fruit and dried powder can all be used to mimic insulin's effects and treat diabetes. (2) Although researchers state that further studies are required to recommend its use for certain conditions, according to a 2004 review published in the Journal of Ethnopharmacology, findings show that bitter melon has some of the following benefits: (3)
Managing blood sugar levels and diabetes
Reducing respiratory infections such as pneumonia
Lowering inflammation and raising immunity
Treating abdominal pain, peptic ulcers, constipation, cramps and fluid retention
Increasing cancer-protection
Reducing fevers and coughs
Lowering menstrual irregularity
Treating skin conditions including eczema, scabies and psoriasis
Antiviral, antibacterial and anthelmintic properties (including those that can be used to prevent or treat parasites, HIV/AIDS, malaria and even leprosy)
Treating gout, jaundice and kidney stones
Managing symptoms of autoimmune disorders including rheumatoid arthritis
Bitter Melon Nutrition Facts
Momordica charantia goes by several common names around the world, including bitter melon, bitter gourd, balsam, bitter apple and carilla fruit. It belongs to the cucurbitaceae plant family and today is primarily grown in two varieties for its medicinal benefits (M. charantia var. charantia and M. charantia var. muricata), mostly throughout parts of India.
Over a dozen different species of the plant can be found growing throughout the world, and the beneficial properties, taste, texture, size and appearance differ from plant species to species. The most widely grown type of bitter melon plant produces a small, round fruit that has a distinct, highly sour/tart taste. The immature fruit is sometimes eaten as a vegetable and added to stir-fries or other recipes, especially throughout Asia. It can be consumed both raw and when cooked, as well as used to make a concentrated extract that contains high levels of anti-inflammatory, antibacterial, antiviral compounds.
According to the National Bitter Melon Council, at least 32 active chemicals have been identified in bitter melon.
What gives the bitter melon plant it's signature sour flavor is a type of alkaloid momordicine compound, which is produced in the plant's fruit and leaves.
In immature vegetable form, bitter melon is also a good source of nutrients including vitamin A, vitamin C, iron and phosphorus.
One of its most important attributes, Momordica charantia contains biologically active phytonutrients and antioxidants. These include chemical compounds such as phenolic acids, glycosides, saponins, alkaloids, fixed oils, triterpenes, insulin-like peptides, and certain types of anti-inflammatory proteins and steroids.
Studies have identified specific phenolic and flavonoid compounds within bitter melon that are responsible for many of its anti-diabetic and anti-cancer effects. These include gallic acid, tannic acid, catechin, caffeic acid, p-coumaric, gentisic acid, chlorogenic acid and epicatechin. Research shows these help to reduce inflammation, balance hormones, regulate appetite, help prevent obesity, prevent tumor growth and much more.
7 Bitter Melon Benefits
1. Helps Normalize Blood Sugar Levels
Findings from both human and animal studies have demonstrated a hypoglycemic effect of concentrated bitter melon extract, meaning it helps to lower blood glucose (sugar) levels and regulate the body's use of insulin. In many ways, bitter melon extract acts just like insulin that the body produces naturally. The Journal of Ethnopharmacology reports that "Over 100 studies using modern techniques have authenticated its use in diabetes and its complications." Diabetic symptoms and complications that bitter melon extract can help to manage include:
Insulin resistance and high blood sugar levels
Nephropathy (kidney damage)
Eye disorders such as cataracts or glaucoma
Hormonal irregularities and menstrual changes in women
Heart complications and blood vessel damage
While multiple studies have found that Momordica charantia can be beneficial in normalizing blood sugar and managing diabetes, its effects seem to depend on how it is consumed. A 2013 study published in the Journal of Agricultural Food Studies showed that bitter melon consumed in both raw or juice form helps to lower blood glucose levels in healthy and diabetic animals, although other studies have found that responsiveness differs depending on the individual.
This study analyzed the hypoglycemic effects of bitter melon extract and seeds on mice with either normal or elevated blood sugar levels. The data showed that bitter melon extract (1 g/kg) significantly lowered the blood glucose level of both normal and diabetic mice. (4) It did so primarily by regulating the insulin signaling pathways in muscles and fat cells (adipose tissues), helping cells to take up more glucose from the blood as needed. Bitter melon was shown to target insulin receptor sites and stimulate downstream pathways, leading researchers to conclude it can serve as a beneficial "regulator of glucose metabolism."
Other research has identified a mixture of active constituents within bitter melon that are responsible for its anti-diabetic abilities. These include: steroidal saponins (known as charantins), insulin-like peptides and alkaloids, which are most heavily concentrated in fruit of the Momordica charantia plant.
2. Fights Bacterial Infections & Viruses
Research has demonstrated that bitter melon contains several forms of antibacterial as well as antiviral agents. These agents are capable of lowering susceptibility to such infections as Helicobacter pylori (a very common bacteria tied to the formation of stomach ulcers when someone's immune function is low), along with viruses including HIV.
A report printed in the International Journal of Microbiology states that powdered bitter melon has been used in Ayurveda for centuries "for dusting over leprous and other intractable ulcers and in healing wounds, especially when mixed with cinnamon, long pepper, rice, and chaulmugra oil." In recent years, bitter melon extract has been successfully used against pylorus ligation, aspirin and stress-induced ulcers in rats, showing significant reductions in ulcer symptoms. (5)
Additionally, studies have identified anthelmintic agents within bitter melon, a group of anti-parasitic compounds that help expel parasitic worms and other internal parasites from the body. Anthemintics work by killing parasites internally, without causing significant damage to the host (the person or animal carrying the parasite).
3. Improves Digestive & Liver Health
There's evidence that bitter melon extract can help reduce stomach and intestinal disorders, decrease kidney stones, help prevent liver disease and improve liver function, help treat parasitic worms that enter the GI tract, reduce symptoms of inflammatory bowel disease (including colitis) and improve overall digestive health. (6) Research done at Annamali University in India showed that extract from bitter melon increased levels of glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase, helping to improve detoxification and prevent liver damage. (7)
Bitter melon also has natural laxative effects, and therefore helps to relieve constipation. A traditional use of bitter melon was for reducing stomach pains and ulcers. Recently, it has even been discovered that it can help act against Helicobacter pylori bacteria that contributes to ulcer formation.
4. Can Help Increase Cancer Protection
Although study results have been inconsistent, several studies have demonstrated bitter melon's efficacy in preventing or managing various types of cancers: lymphoid leukemia, lymphoma, choriocarcinoma, melanoma, breast cancer, skin tumor, prostatic cancer, carcinoma of the tongue and larynx, bladder cancer and Hodgkin's disease.
How does bitter melon act like a cancer-fighting food?
The Department of Biophysics, Molecular Biology and Bioinformatics at the University of Calcutta states that Momordica charantia has "anti-cancerous, anti-mutagenic, anti-tumourous" properties. (8) While more research is still needed, to date a small group of studies have found that cancer patients using bitter melon in addition to other treatments have shown promising results. Extracts of bitter melon have been shown to increase metal chelating, promote detoxification, prevent lipid peroxidation, and inhibit free radical damage which contributes to cell mutations and tumor growth. (9)
The School of Biomedical Sciences at University of Hong Kong has identified over 20 active components within bitter melon that have anti-tumor properties. On conclusion of their research regarding bitter melon as an "anti-diabetic, anti-HIV and anti-tumor compound," they stated that bitter melon is "a cornucopia of health and deserves in-depth investigations for clinical application in the future." (10)
5. Reduces Respiratory Disorders & Symptoms
Through increasing detoxification, improving blood flow, lowering inflammation and decreasing free radical damage, bitter melon is capable of preventing common illnesses such as coughs, colds or the flu.
A strong immune system and well-functioning digestive system are essential for fending off potential infections and diseases, as well as reducing seasonal allergies and asthma. In Traditional Chinese Medicine, juice from bitter melon fruit has been used to treat dry coughs, bronchitis and sore throats for hundreds of years. (11) Studies today show that bitter melon juice, fruit and seeds can be beneficial for preventing respiratory illnesses, coughs, mucus and food allergies.
6. Helps Treat Skin Inflammation & Wounds
Several studies have identified anti-inflammatory compounds within bitter melon that help treat skin conditions such as eczema and psoriasis. Due to its antibacterial properties, traditionally (and sometimes still today) bitter melon has also been used topically on the skin to treat deep skin infections (abscesses) and wounds without the use of antibiotics.
7. May Help Prevent Obesity & Heart Disease
The fruit extract of bitter melon has shown strong antioxidant activities in both human and animal studies. In addition to balancing hormones related to diabetes, there's potential for bitter melon to act as a therapeutic agent for preventing obesity and other symptoms related to metabolic syndrome and cardiovascular disease (such as high cholesterol and high blood pressure).
Although more research is still needed, experimental animal and clinical studies show that bitter melon is beneficial in preventing weight gain by way of mediating and inducing lipid and fat metabolizing processes, gene expressions that control appetite and body weight, and reducing inflammation.
A 2015 report published in the Journal of Lipids showed that bitter melon has metabolism-boosting effects:
Proinflammatory cytokines and oxidative stress have been shown to be responsible for developing metabolic disturbances, such as insulin resistance and activation of immune response in liver, adipose tissue, and muscles. Several investigational reports suggest that bitter melon can reduce body weight in high fat diet induced obesity in laboratory animals. Bitter melon supplementation prevented the body weight gain and visceral fat mass significantly in rats fed high … weight reduction may be a result of increased fatty acid oxidation which ultimately facilitates weight reduction. (12)
Asian and African folklore and herbal medicine practitioners were some of the first to adopt bitter melon. The fruit has been used in healing systems native to places such as India, Indonesia, Turkey, Japan and Turkey for at least 700 years!
In Turkish folk medicine, bitter melon is known as a stomach soother, despite its strong, sometimes off-putting taste. Turkish healers used bitter melon hundreds of years ago to soothe ulcers, constipation, water retention, bloating and more.
In India, bitter melon is considered one of the most important plants for Ayurvedic "ethnobotanical practices." In Ayurveda, the fruit has been used to help balance hormones, manage symptoms of diabetes, reduce digestive upset, treat skin disorders or wounds, and also as a natural laxative for treating constipation. Bitter melon has also earned a reputation for acting a natural cough suppressant and protector of respiratory diseases.
Today, bitter melon is still widely used as a vegetable in daily cooking in places like Bangladesh and several other countries in Asia. As it has been for hundreds of years, it's still used as a medicinal plant for the treatment of various diseases in developing countries (like Brazil, China, Colombia, Cuba, Ghana, Haiti, India Mexico, Malaya, Nicaragua, Panama and Peru) due to its availability, low cost and multi-purpose uses. It's also a popular addition to stir-fries in China, India and Japan and promoted for its digestive-boosting benefits.
How to Use Bitter Melon
Bitter melon fruit can be eaten on its own, cooked with, or consumed in extract/tablet form.
Look for immature melon fruit that is green, firm and free from bruising or splitting. Store it at cool temperatures, ideally in the refrigerator, for 1–2 weeks or until its green color starts to shot spots.
If you're able to find the whole fruit, you can try cooking it in a way that it's traditionally prepared in Asia: stir-frying it with potatoes, garlic, chili and onion until some of its strong smell is reduced.
Up to 100 milliliters of fresh bitter melon juice can be taken once a day. If you'd like to reduce the bitterness of the fresh fruit or fresh fruit juice, use a small amount diluted with fresh squeezed fruit or veggie juice, or add a small amount of raw honey. (13)
Dosage of bitter melon extract depends on the condition being treated. Most research shows that taking around 1000–2000 milligrams daily has the strongest effects. Many brands recommend splitting doses into 2–3 servings and taking capsules after meals to help with absorption.
Bitter melon is usually taken in doses of 1–2 capsules, three times a day after meals, for up to 3 months. This amount has been shown to help with improvement in blood sugar management/diabetic conditions, but not enough is known about its effects when used for more than 3 months straight.
Look for pure bitter melon extract in tablet or capsule form that is ideally certified organic, Non-GMO Project Verified, gluten-free, magnesium stearate free, and contains no synthetic additives.
Based on research that's available at this time, bitter melon is meant to be used in conjunction with other preventive measures (like eating a healthy diet and exercising to control inflammation), along with conventional treatments when necessary. Here are some possible side effects and precautions to consider before using bitter melon products: (14)
While this melon has proven hypoglycemic effects, available scientific data is not sufficient to recommend its use for treating diabetes without careful supervision and monitoring. The Memorial Sloan Kettering Cancer Center concludes that bitter melon "cannot be recommended as a replacement therapy for insulin or hypoglycemic drugs" at this time, so if you're pre-diabetic or diabetic, it's best to talk to your doctor about using bitter melon extract in addition to your current treatment plan. Because bitter melon lowers blood sugar, it can interact with medications for diabetes. If you take diabetes medications keep in mind it might lower your blood sugar too much, and therefore monitoring is recommended.
Pregnant women, those who are trying to become pregnant, and women who are breastfeeding should not consume bitter melon, since research shows that it has some abortifacient properties (those that can cause miscarriages), can cause menstrual bleeding, and has certain anti-fertility capabilities.
If you've recently undergone surgery, have been fasting, or lost substantial blood for another reason, bitter melon should be avoided, since it can interfere with blood sugar control and cause side effects like dizziness or fainting.
Bitter melon (also commonly called bitter gourd) is a sour, green fruit is commonly eaten in Asia and used around the world for its many medicinal properties.
Benefits include increasing immunity, lowering diabetes symptoms, fighting free radical damage and inflammation, treating skin problems, improving digestion and helping to prevent cancer.
It can be consumed raw, cooked or extract and tablet form. Between 1,000–2,000 milligrams of this melon extract daily (split into 2–3 dosages) is usually recommended for treating most conditions, although bitter melon should be avoided by pregnant women, those taking diabetic medications, and people recovering from surgery.
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text:
Q: Ошибка при использовании конструктора class Ctest
{
    public:
    int Dtest;
    Ctest (int _Dtest = 0 ) { Dtest = _Dtest; }
    void operator << (Ctest&);
};

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{
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оператор << не хочет работать, как заставить.
error C2679: бинарный "<<": не найден оператор, принимающий правый операнд типа "Ctest" (или приемлемое преобразование отсутствует)
message : может быть "void Ctest::operator <<(Ctest &)"
message : при попытке сопоставить список аргументов "(Ctest, Ctest)"

A: В выражении
_Ctest << Ctest(1);

Ctest(1) это rvalue выражение. А дальше оно пытается вызвать перегруженный оператор <<, который принимает по ссылке. А обычная (lvalue) ссылка не может принять rvalue. Что делать? самый просто способ - сделать ссылку на константу
void Ctest::operator << (const Ctest& _Ctest)
{
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};

или сделать вот такую перегрузку:
void Ctest::operator << (Ctest&& _Ctest)
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};

Я бы делал const& и этого было бы достаточно. Но если объект "тяжелый" и для него можно написать хорошую функцию перемещения, то перегрузка и для rvalue - самое оно.

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text:
Phreatia flavovirens är en orkidéart som beskrevs av Paul J. Kores. Phreatia flavovirens ingår i släktet Phreatia och familjen orkidéer. Inga underarter finns listade i Catalogue of Life.

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The University of Texas MD Anderson Cancer Center Chair of Immunology Jim Allison, Ph.D., whose pivotal insight to attack cancer by treating the immune system instead of the tumor revived cancer immunotherapy, has been named to the 2017 TIME 100. His approach launched a completely new way to treat these diseases, improving patient outcomes and transforming the course of cancer research.
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Allison holds the Vivian L Smith Distinguished Chair in Immunology and is director of the Parker Institute for Cancer Immunotherapy at MD Anderson.
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Nice Staff, Clean room. Beautiful garden. Tram station near by, Free parking on site Ok breakfast.
Garden One of the staff members helped us prolongue our stay with a day prior to our original booking. He made sure we did not have to change rooms The painting above the room.
This is a great hotel, very beautiful, clean, quite and comfortable place. Don't be afraid of the distance between the hotel and the center, tram and bus station is just next to the hotel, every of the numbers takes you to the center on 20 - 30 min. Also the breakfast was very rich and tasty! Last but not least the girl at the reception is so kind! Thanks to Hotel Branik for making our trip to Prague easier and prettier.
xxxxxxxxxxxxxxxxxxxxxxxxxxx food. xxxxxxxxxxxxxxxxxxxxxxxxxxxx bier. xxxxxxxxxxxxxxxxxxxxxxxxxxxx parking.
Hotel Braník This rating is a reflection of how the property compares to the industry standard when it comes to price, facilities and services available. It's based on a self-evaluation by the property. Use this rating to help choose your stay!
Enjoying a scenic location in a small park on the banks of the Vltava river, the Braník hotel offers free on-site parking. It is only 8 tram stops or a 15-minute ride to the center of Prague, with the nearest tram stop reachable in just 1 minute on foot. All major points including Charles Bridge, Prague Castle and the Jewish Quater can be accessed easily.
All rooms at the Braník hotel have a private bathroom and satellite TV. Free WiFi access is available in all areas of the hotel.
Grilled specialties can be enjoyed in the restaurant featuring a charming garden terrace next to a private pond.
Hodkovičky golf course including a training area is a 10-minute drive away. In the immediate surroundings you can also find the O2 Žluté lázně sports and relaxation center, the Podolí public swimming pool and a path for biking or inline skating. The Novodvorska Plaza Shopping Mall can be reached in 12 minutes by bus.
Sightseeing tours as well as taxi service can be booked at the Hotel Braník.
When would you like to stay at Hotel Braník?
This double room has free WiFi access and a private bathroom.
This triple room features a seating area, free WiFi access and a private bathroom.
This room has free WiFi access and a private bathroom.
This quadruple room has free WiFi access and a private bathroom.
House Rules Hotel Braník takes special requests – add in the next step!
Hotel Braník accepts these cards and reserves the right to temporarily hold an amount prior to arrival.
The room was poorly lit. If they could add more lights in the rooms that would be very helpful for travelers.
The staff was not clean in terms of uniform as well as customer service and the breakfast was very poor with the cheap food.
Very poor and old hotel. No shades in windows made me to have to wake up at 6 am during the first light.
When we arrived they asked to pay 11€ more (without a receipt) and they didn't specified the reason. We had pay the full asked price before arrival via this site. Awful breakfast, which by the way, it was just undrinkable bending-machine-coffee.
Tram station nearby and warm at night.
It is good and cheap.
Nem porszívóztak és nem ürítették a szemetet.
The room was quite enough big. For few staying good. The hotel was good situated. Very good connection for the public transportation.
Clean, friendly staff, not away from train station, free parking.
Location of the hotel is outside the main city, but the last station of most trams drop in-front of the hotel. The fridge wasn't operating and the breakfast was okay.
Comfortable and spacious room with helpful staff.


text:
Q: Documentum DQL join by repeating attribute I tried to join these tables using repeating attribute:
table1:
r_object_id           codes
...                   1,2,3,4,5
...                   7,6,3,4,5
...                   1,5,4,2,3

Where codes attribute is the repeating attribute.
table2:
r_object_id      name      code
...              hello      1
...              aba        2
...              father     3
...              mother     4
...              hello2     5
...              hello3     6
...              hello4     7

I want result like this:
table1.r_object_id      names
...                     hello,aba,father,mother,hello2

What can I do?

A: This is not possible in one DQL query. But you have some options how to solve it.
1) Using one DQL but having one row per one repeating value:
SELECT DISTINCT t1.r_object_id, t2.name FROM table1 t1, table2 t2 WHERE t1.codes = t2.code ENABLE(ROW_BASED)

The result will be like this:
r_object_id      name
0900ad1234567890 hello
0900ad1234567890 aba
0900ad1234567890 father
0900ad1234567890 mother
0900ad1234567890 hello2
0900ad1234567891 father
0900ad1234567891 mother
...

2) Pair values in an application - for example using Java. Where you select all records from the table2 by one query and stores them into Map<String, String> codeTable, where code attribute is as a key and name attribute as a value. Then select records from table1 by another query and pair values from the repeating attribute (codes) with values from the codeTable map.


Bring you vision to this 1749 historic grist mill. Original mill works are still intact and if you love history you will be enamored. The mill previously housed an an antique emporium for 20 years. Great potential for many uses in Village Commercial zone. Situated minutes from bustling Doylestown and the quaint river town of Riegelsville. The original mill workings are a sight to be seen and a beautiful backdrop for your new business or residential venture.The 3 story building offers 6,819 sq feet,plus the storage "bunker" offers 1,404 sq ft. Set on 6.19 acres,additional parking and a pond.


text:
Memoirs and Misinformation
By Jim Carrey and Dana Vachon
NEW YORK TIMES BESTSELLER • "None of this is real and all of it is true." —Jim Carrey
Meet Jim Carrey. Sure, he's an insanely successful and beloved movie star drowning in wealth and privilege—but he's also lonely. Maybe past his prime. Maybe even ... getting fat? He's tried diets, gurus, and cuddling with his military-grade Israeli guard dogs, but nothing seems to lift the cloud of emptiness and ennui. Even the sage advice of his best friend, actor and dinosaur skull collector Nicolas Cage, isn't enough to pull Carrey out of his slump.
But then Jim meets Georgie: ruthless ingénue, love of his life. And with the help of auteur screenwriter Charlie Kaufman, he has a role to play in a boundary-pushing new picture that may help him uncover a whole new side to himself—finally, his Oscar vehicle! Things are looking up!
But the universe has other plans.
Memoirs and Misinformation is a fearless semi-autobiographical novel, a deconstruction of persona. In it, Jim Carrey and Dana Vachon have fashioned a story about acting, Hollywood, agents, celebrity, privilege, friendship, romance, addiction to relevance, fear of personal erasure, our "one big soul," Canada, and a cataclysmic ending of the world—apocalypses within and without.
Grade: Grades AP/IB
JIM CARREY is an award-winning actor and artist.
DANA VACHON is the author of the novel Mergers and Acquisitions. His essays and journalism have appeared in The New York Times, Slate, and Vanity Fair. He lives in Brooklyn.
"A satirical adventure in which Carrey plumbs the chasms of Hollywood's self-obsessed culture."
—Dave Itzkoff, The New York Times
"A simultaneously baffling and mesmerizing examination of Carrey's psyche . . . a reimagining of the traditional Hollywood tell-all."
—Thomas Floyd, The Washington Post
"Memoirs and Misinformation is, like the twisted political drawings Carrey posts on Twitter, entirely its own thing. A satire of Hollywood's self-absorption coinciding with the end of the planet, none of it is real ... except when it is . . . A wholly strange work of autofiction, laden with symbolism and metaphor, sometimes beautiful, sometimes tragic."
—Glenn Whipp, Los Angeles Times
"An engaging, fun tale that plays with the public perceptions of celebrities, questions our compulsive need to view, and contains a gloriously off-the-wall conclusion."
—Alexander Moran, Booklist
"Not a typical tell-all. . . . blends moving autobiography, name-droppish tabloid fodder, science-fiction, and anti-capitalist screed."
"A mad fever dream. . . Carrey and his collaborator Vachon pull out all the stops as their protagonist Jim Carrey careens from midlife blues through love and career complications toward the apocalypse . . . gems of comic fantasy and the nuggets of memoir gold."


text:
A sample of research exploring self-dehumanization and moral behavior, reading skills in children at risk of dyslexia, and prosocial predictions by bottlenose dolphins. More
Does the Trolley Problem Have a Problem?
Picture the following situation: You are taking a freshman-level philosophy class in college, and your professor has just asked you to imagine a runaway trolley barreling down a track toward a group of five people. The only way to save them from being killed, the professor says, is to hit More
Cambridge Analytica Scandal Casts Spotlight on Psychographics
A political data firm's use of Facebook data for targeted messaging reveals the exploitation of psychometric data that some psychological scientists have warned about. More
Polluted Air May Pollute Our Morality
Data from archival and experimental studies indicate that exposure to air pollution, either physically or mentally, is linked with unethical behavior such as crime and cheating. More
Moral Judgment
Société Française de Psychologie Fosters Science–Practice Links
The Société Française de Psychologie shares its efforts to settle misunderstandings, build trust, and foster collaboration between researchers and practitioners. More
Better Minds Ahead: Understanding Cognitive Enhancement
Scientists from Europe and North America share the latest findings on the promise and limitations of video games, "smart" drugs, and other tactics that people are turning to for cognitive enhancement. More
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Here is the answer to storing those sooty and dirty pie irons! Barely Roughing It's Pie Iron Case will store two pie irons with room to spare for small marshmallow forks. Made of high quality material, these cases will provide years of dirt free storage. Order one for your friend!


LIKE HUMAN BODY LANGUAGE, graphic design expresses similar implied non-verbal business attitudes or values. Graphic design is a method of differentiating business or products in the market. Graphic design is considered of equal value to other intangible assets like special customer offerings or an in-house mailing list or goodwill. Design builds a sense of community or habitat for customers and employees. Graphic design really is the body language of business.
THERE ARE TRADITIONAL positions for elements for different format like newsletters, a letterhead, a business card, a catalog, etc. It's best not to deviate from tradition. People search the usual spot for information. If it is not there, it becomes a barrier to understanding. This is where creativity becomes a negative. Examples: Headlines should usually be below a photo not above it. On a brochure, ad, or slick, the logo and address should occupy the bottom right-hand corner. Place it anywhere else and people can't seem to find it. (In web page creation, this is called usability.) Are things where people expect them to be? Placement of design elements is also influenced by printability, mailability, and postal codes.
client communication goals. It affects all design elements. It needs to be appropriate to the audience. It may use a metaphor, a stereotype, or a cliché. These can accelerate understanding. A theme builds upon historical emotional cues to alter the buyers perception of companies and products. Words, color, fonts, images, and symbols all orchestrate to create a unified theme.
color palettes. Colors can also be sampled from photos or generated using Color Harmony Theory with software to select complementary and harmonic color schemes.
ALL WORDS AND SYMBOLS can be evaluated, ranked, or scored. There are 3 aspects to any word or symbol.
Evaluation is the degree of favorableness. How good-bad, fair-unfair, valuable-worthless, honest-dishonest does the word seem.
Activity is the degree of movement or activity in an object or event. How fast-slow, active-passive, varied-repetitive, vibrant-still, dynamic-static does the word seem.
Can you feel the difference in these words?
Meaning may be derived from an elements position in relationship to other page elements. Two different symbols or images side-by-side can imply a third unspoken meaning. Or something on the page may imply something is happening off the page. The human imagination fills in the blanks. This is called implication. Our imagination is the great special effect method.
THE GRID CONCEPT is from the German Bauhaus design school (1919-1933) The Bauhaus believed industrial potentials were to be applied to satisfactory graphic design standards, regarding both functional and aesthetic aspects. The Grid concept affected all design fields from architecture to product packaging. This invisible grid is consistent from page to page and consists of rows and columns. It is the skeleton for the design. Breaking the grid causes tension in the viewer. Project limitations (time, budget, energy) define what page format will influence the invisible typographic grid. The grid is a structural layout tool. Some grid patterns work best for certain formats, like 12-columns on a newspaper. A grid produces beautiful books, brochures, magazines, and websites. Grids make it possible to bring all the elements of design typography, photography, and drawings into harmony with each other. When telling a story sequentially, over a series of pages, contrast is needed on the overall sequence as well as on the page. Two opposites: the need for order and the need for variety are needed. Without order, the reader is likely to become tired, frustrated, or bewildered by an overabundance of details. Yet without variety, the reader may become bored, overwhelmed, or numbed by too much repetition.
MARKETING ADAGE: e2 = 0 means Emphasizing Everything equals Emphasize Nothing. There is a hierarchy of page elements. This affects placement, size, visual weight, color density, and more. No emphasis creates confusion and visual noise. Obviously, two things cannot be dominant or emphasized at the same time. The page needs a hierarchy of dominant, subordinate, and accent ranking of colors, typography, and images. Without a hierarchy, there is no emphasis. Without emphasis, there is confusion or chaos. The idea is to communicate. Without emphasis, the viewer doesn't know what to focus on and gets overwhelmed and frustrated. Bad pages have weak focus and weak hierarchy. The central theme or idea would be muddled. Order is determined in the human mind, but there are visual cues that help direct our mind from most important to least. This is not always easy. Sometimes we have to discard something we really like to achieve the right emphasis.
PHOTOGRAPHY IS A PRINCIPLE communication device for design. Good photography generates interest and curiosity. It has energy. The most powerful or novel words in the body text, when converted to images, enable the viewer to quickly fill in the blanks. Photos frequently influence the theme color palette. If photography is beyond the budget, illustration sometimes works in its place but not necessarily for products. Products need the realism of photography even if it's only a dummy or mock up. The potential customer will generally not believe an illustration or drawing is a real product.
Text placed over photos usually ruins the type and the photo simultaneously. About 30% of space in a publication is allocated to photos, as a rule of thumb. Besides photography as rectangular boxes on the page, it adds interest when we include a cutout photo object or two. A cutout is a photograph from which the background is removed to produce an organic edge. This image breaks the grid. Word wrap can be used around the edge. It's a visual break from monotony and gives more life and freshens a page.
Photography helps the customer visualize what a product will be like in their possession after delivery. This should give a feeling of empowerment to the customer (not for the product or company.) The customer gets to be the hero, not us.
Previous Previous post: #52 "Award-winning design" is a hollow credential.


Anyone who dresses up in their best 80's outfit receives a 5 dollar discount at admissions! Don't forget to remind your families!
COnGrats to our 2019 coaches Gamble winners!!
A week prior to meet (February 7, 2019), coaches will submit names of 3 athletes per event any level. The 3 scores for the selected athletes will be counted toward a chance of winning a coaches' PRIZE!
Copyright © Jock Jamz Invitational. All rights reserved.


text:
Foundation BEBO
Requirements research file
Voluntary Harmonisation Procedure (VHP)
Non-WMO
ECTR
Submission to Foundation BEBO
Meeting schedule 2022
On 31 January 2022, the CTR will enter into force. The Minister of Health, Welfare and Sport has set the rates for the medical-ethical assessment in the Netherlands of research under the EU
regulation for drug research.
These rates can be found on the CCMO website here.
The Ministry of Health, Welfare and Sport can adjust the rates annually.
These national rates apply to assessments by all accredited METCs authorised to assess drug research and the CCMO. If a study is submitted via the ECTR (CCMO), the invoicing also goes via the CCMO. During the first year, clients can opt to have drug research reviewed under the current legislation and regulations rather than under the CTR. The BEBO Foundation has opted in this case to bring the rates into line with the CTR rates as of 31 January 2022. We use the submission date to determine the tariff to be charged. This also applies to submissions of ongoing studies, e.g. in case of an amendment or DSUR. The following should be taken into account:
The "High-rate research file" applies to international research which is assessed according to current legislation and regulations, because in this case the BEBO Foundation conducts the assessment entirely on its own.
The fee for CTR part 2 is charged for all studies, because under the current assessment system this is always part of the initial submission package.
The subscription fee will lapse on 31 January 2022. However, there will be a fee for assessing a DSUR.
For research that is assessed according to current legislation and regulations, two rates apply instead of three rates when it is assessed under the CTR. This concerns the following two options:
DSUR: €500
DSUR: €1000 when the substance is examined in a study in the Netherlands only.
The subscription fee charged in the year preceding the DSUR for the study in question will be deducted from the invoice for the DSUR.
The prices do not include VAT.
Rates up to and including 30 January 2022
The rates below apply up to and including 30 January 2022.
The MREC of BEBO foundation divides submitted protocols into different levels of complexity. We charge different rates for these levels. The division into the different levels of complexity is done as follows:
Issue of a non-WMO statement (upon assessment whether or not subject to WMO)
Research with a drug that is already registered
Research with an unregistered study drug, where this study drug has previously been reviewed by the MREC of the BEBO foundation in another research file
Research with an unregistered study drug that has not previously been reviewed by MREC of BEBO foundation
General experimental research, also with products other than medicines (e.g. food additives)
A combination of 3 or more C studies in one protocol
First in Human (FIH) studies with biologicals
Type of review
rate excl. vat
A (non-WMO studies) € 500,-*
A (non-WMO studies to be discussed in meeting) € 1.000,-*
B protocol € 5.400,-*
C protocol € 7.200,-*
D protocol € 8.800,-*
Review of substantial amendments by the chairman (and two other MREC members if required) € 400,-
Review of substantial amendments by the chairman (and more than two MREC members if required) € 800,-
Review of substantial amendments in a meeting € 2.700,-
Subscription rate per 6 months € 250,-
*This is a indication, the rates depend on the size and type of protocol and the phase of the study.
If a time slot has been reserved at a meeting for a study and the study is rescheduled / canceled on or after the submission date, we will charge you the full review rate.
If the study is rescheduled / canceled up to 7 days before the submission date, we will charge you 50% of the review rate.
Subscription fee for long-term studies
The subscription fee is a fee for the management of your research file (this includes, for example, non-substantial amendments, archiving and, where necessary, assessing SUSAR's, SAE's, safety reports, progress reports and final reports). This applies to studies lasting six months or more.
This fee is € 250,- per six months (you do not have to pay upfront, invoice will follow afterwards).
We will charge the fee starting from the date of approval of the study. We will stop charging upon notification that the study has ended in the Netherlands.
If the study ends before the subscription fee is due, you will not receive an invoice.
MREC of the foundation BEBO
Dr. Nassaulaan 10, 9401 HK Assen
Members METC: memberportal
CRO Inbox
Attention! Only for users
Submission on a CD-ROM repealed
New English Cover Letters
Introduction of cancellation costs
Subscription rate long-term studies
MREC Assen
No rights can be derived from this web site. Although the Stichting BEBO takes every effort to ensure that the information contained on the web site is accurate, it cannot accept any liability for the accuracy of this information.


A site dedicated to preserving the history of concrete pavements.
Home > Historical Concrete Pavements Explorer > Pittsburg > Test Road > Pittsburg Test Road – Second Test Road in U.S.
Pittsburg Test Road – Second Test Road in U.S.
The Pittsburg Test Road was sponsored by Columbia Steel Company. The test loops were built off of the roadway between Pittsburg and Antioch, California. The purpose of the test was to determine the benefits of using reinforcing steel in concrete pavements. This was the second known test road site in the U.S. It included thirteen test sections to look at different cross sections (including thickened edge), reinforcing, and longitudinal joints. Surplus army trucks were used with solid tires to traverse the instrumented slabs. The sections ranged from 5 to 8 inches and had various levels of reinforcement.


text:
Nigerian Press
Raye to perform DJ set at Smithfield Beach Volleyball on Thursday 4 August.
One of many live performances as part of Birmingham 2022 Festival.
Part of vibrant cultural programme staged alongside the Birmingham 2022 Commonwealth Games.
International superstar and English singer-songwriter, Raye, will perform at the Beach Volleyball on Thursday 4 August. Performing at the Smithfield site at the end of the 14:30 session, Raye's live set will be available exclusively to Beach Volleyball ticket holders. Her performance comes as part of the Birmingham 2022 Commonwealth Games cultural offer.
Raye is an English singer and songwriter. In 2016, she had her breakthrough by featuring on the singles "By Your Side" by Jonas Blue and "You Don't Know Me" by Jax Jones. Raye was short-listed for the BBC Music Sound of… Award for 2017, has seven top 20 singles to her name, four Brit award nominations and more than 1 billion global streams.
Raye will be one of many performers to feature in the Smithfield Festival, part of the cultural celebrations which run alongside the Birmingham 2022 Commonwealth Games and are free for the public to enjoy.
One of two major Festival Sites hosted in Birmingham's city centre – Smithfield and Victoria Square – the Smithfield site will host a festival of festivals with a different cultural partner taking to the specially commissioned three-sided Beacon Stage every single day, as well as DJ sets and live performances to accompany the Games.
The Smithfield cultural offer includes daily performances from acclaimed dance-circus ensemble Motionhouse, a new inflatable art installation inspired by Spaghetti Junction and screenings of new films, music videos and digital commissions screening throughout the day.
Smithfield's Beacon Stage features DJs from BBC Asian Network, Selextorhood, who champion and empower women and gender minority DJs, MADE Festival, Mostly Jazz Funk and Soul, and Break Mission and Eric Scutaro. A closing dance party will also take place on 7 August for the final day of the Festival Site.
The place to be this summer, Smithfield will bring everyone together to celebrate the best of British and Commonwealth culture and provide a perfect accompaniment to the world-class sporting events on show.
Festival Sites are free to access and will include live performances, entertainment and special events, as well as giant screens where people can gather to watch the sporting action. Creative, loud and celebratory, the programme is full of events that will bring sport and culture together.
In this article:Birmingham2022, Commonwealth Games
Written By Nigerian Press
Team Nigeria
Tobi Amusan crown 2022 queen of tracks
Pele or Maradona debate continue raging over who was 'GOAT'
Liberia's President backs Morocco's hosting bid
CAF unveils mascot for Championship of African Nations Cup
Commonwealth gold medalist, Grace Nwokocha suspended for doping
Nigerian sprinter Nzubechi Grace Nwokocha who won gold in the 4×100 metres relay at this year's Commonwealth Games in Birmingham, has been provisionally suspended...
BBC deletes Nigeria, South Africa, India from Commonwealth Games final medal table
British Broadcasting Corporation (BBC) has knocked Nigeria from the Commonwealth Games final medal table ranking posted on Facebook. This was contained in Commonwealth table...
CWG 2022: Dare commends Team Nigeria's performance
Mr Sunday Dare, Minister of Youths and Sports Development on Monday commended Team Nigeria for its performance at the 2022 Commonwealth Games in Birmingham....
England break their Commonwealth Games medal record
Host nation England secured their most successful Commonwealth Games ever with a raft of medals on the final day taking them to 176. England's...


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text:
Fall Issue
Theater construction finished and new classes have started within the theater.
IUSD releases COVID-19 dashboard to keep track of cases in schools
School Arts
Head to Head Topics
Humans of Woodbridge
Web Teaser
A Golden Opportunity For Sports
A new opportunity is made for students who do not participate on traditional sports team
Saryu Vatte, Staff Writer|November 26, 2019
Photos by Maddy Cornelio
Students participate in a Special Olympics basketball game at lunch.
A new opportunity this school year gives students who are not able to participate in traditional sports a chance to participate. Allison Hoertig, senior and club president, founder of Special Olympics club that allows students to take part in basketball, flag football and soccer.
"The best high school experiences I've had was through sports and I wanted to be able to bring that to a different group of people. The Special Education Department doesn't get that opportunity…so I wanted to make a program where they could enjoy the same things I enjoy." Hoertig said.
Students of all grades in the special education department do not have the option to take part in sports other than in physical education classes. Many students during their four years of high school tend to join a sports team for a year or so. Hoertig wants to give everyone a chance to do a sport that they enjoy not only at Woodbridge High but throughout the Irvine Unified School School District.
"I'm really excited we're able to bring this to Woodbridge and to bring it to the students giving them an opportunity to do sports and…be part of a team," club advisor and Special Education lead, Nicholas Card said.
The club is about bringing people together and having fun competing in sports that they have never done before at least once every other week. Hoertig wants the special education students to feel they are a part of the school. "It's a great way to show our school uniting together and cooperating with people to help each other out. The purpose of this club is to have more students involved and join together." Special Olympics vice president and senior, Isabelle Kouyoumdjian said.
The club president, members and advisers are hoping to make progress this year by having their program spread throughout other schools not just Woodbridge High. Kids of all grades and ages should get the chance to do a sport that they may enjoy or want to try.
Woodbridge High Athletes and Major Sports Adapt to COVID-19
Moon Camp Surmounts the Challenge of Being an Athlete in Quarantine
Athletes Training on Their Own
Warriors Take Sports to the Next Level
Boys Lacrosse vs. Girls Lacrosse
Non-School Sports
In Remembrance of Kobe Bryant
Woodbridge High Soccer Takes Two League Championships
Warriors Fuel For Competitions
Sports Clubs on Campus
Woodbridge's Haunted Homecoming
The student news site of Woodbridge High School


text:
$10: The price of admission into the Xbox ecosystem next generation
by woelfel
Xbox Game Pass is the big bet by Phil Spencer that ultimately got him the seat on the senior executive leadership team at Microsoft.
Phil took the reigns of Head of Xbox after Don Mattrick left Microsoft from the disastorous launch of the Xbox One. At that point, Phil had to right the ship of where Xbox was heading and started making "user-friendly" moves with removing the Kinect. Later on he had to show his value to the Windows organization led by Terry Myerson at the time and then you saw things like Xbox Play Anywhere, that allowed you to play Xbox and PC games through the Microsoft Store with one payment. While this was happening, Xbox wasn't getting any increase in budget and was really cash strapped and the games that were being released weren't doing so well critically and commercially outside of the Forza Horizon series. While all of this was going on and Windows was being split apart, Phil was already setting up his organization for the future under CEO Satya Nadella. He had to prove out his organization's worth but he knew that as soon as Satya became CEO, which wasn't that far off from when Phil became Head of Xbox. That's when last year Xbox started Xbox Game Pass, a subscription service at $10 a month for over 100 games.
Over the course of several months Phil and Satya definitely talked about gaming and see where it was going and Phil has been very adamant on focusing on the user and letting people play games whereever they are and on any device that they were on (this type of talk started with Xbox Play Anywhere). I don't know this for sure but I can bet that Phil talked to Satya about streaming and Xbox Game Pass and how it can be the subscription and the future for their platform. He obvoiusly had to crunch the numbers for potential subscriptions and have an understanding how they will reach billions of users. That's when xCloud came in. Cloud gaming isn't a new "thing" in the technology space as it really started with OnLive, which eventually would be bought by Microsoft's competitor Sony through Gaikai. There is an Giantbomb E3 interview with Phil, I believe it was last year after Game Pass launched where he talked about streaming and that they couldn't do it until it financially made sense. A couple months ago, xCloud was introduced and it showed how Microsoft had put 4 Xbox One S stripped apart and put into blades. I believe this will be true of the first trials of the service and then they will go bigger into those blades so that it is not 1 user per "Xbox One S" inside of a blade and instead have them powerful enough to virtualize sessions. That's when it will make financial sense and something that is scalable into the billions of users.
With the introduction of xCloud and knowing how Xbox Game Pass works, there is a connection between them in other forms of our lives, media content. Netflix and Spotify both have streaming as apart of their subscription and that's how they can scale to all over the globe. This is something that Phil recently said in an interview that there is a synergy there:
"And obviously, when you look at that, we have multiple business models that will work with streaming. But, the connection of streaming with the subscription model makes a ton of sense. You see it in music, you see it in video. So, you can look at Project xCloud and you can look at something like Game Pass, and you can see there is a natural synergy between those two." https://wccftech.com/spencer-hesitate-studio-only-one-device/
That's why I believe that the xCloud service will be apart of Xbox Game Pass by default. Microsoft has been following Netflix's model all the way through and it is an understood model that everyone in the world understands, they are just bringing that model to gaming. As I stated in this forum post https://www.thurrott.com/forums/microsoft/xbox/thread/xbox-live-multiplayer-paywall-why-i-think-it-will-go-away , I believe that the multiplayer paywall will go away because of XGP (and in that same post I stated that the future of Xbox Game Pass was streaming). Microsoft wants to reach as many users as possible with a model that they understand, I pay a low price to stream content. They want to roll this out globally, and that's how they can grab other parts of the market that don't want to buy a console (or they don't even sell a console in that region). I also believe that with this subscription you will also be able to stream your own games and not only the ones in the Xbox Game Pass library. Microsoft doesn't want to stop you from playing whereever you are, but they do need you to pay to use their service, the more you play, the more likely you are to buy something like Downloadable Content or Microtransactions. Microsoft also doesn't care what device you are running on be it a console, pc, mobile. They just want you to be a gamer into their ecosystem.
Microsoft has done some very bold moves since Satya has become CEO and I think the next big one will be this one for gaming. The next generation of gaming will have more options than every before for a user. Microsoft will have a streaming console as revealed from Brad Sams, they will have multiple consoles (S and X) but they will also have a streaming service for any device. I think that the latter is going to be what puts Microsoft over the edge. I look at something like this:
$10/mo: Use your own device (mobile, Xbox One console, etc…), stream games that you own and Xbox Game Pass
$10/mo + ($99-$149) : Use your Xbox "5C" streaming console, to stream your own games and Xbox Game Pass
$10/mo + ($299-$399): Use your Xbox "5S" console to play games locally and Xbox Game Pass (also can stream to other devices)
$10/mo + ($499-$599): Use your Xbox "5X" console to play games with highest fidelity and Xbox Game Pass (also can stream to other devices)…i think this device will have a form of real time raytracing personally.
This allows Microsoft to satisfy every type of customer out there. If you want to own a Microsoft console or you don't want to and you just want to try out their games. Getting that subscription money from users that wasn't even a customer of Xbox before can now become one with the lowest barrier to entry, $10. Their total addressable market is in the billions of users. There's a huge mobile gaming market in Asia that is one of Microsoft big targets. Microsoft has actually started a gaming asian group for lack of a better term that will outreach to developers out there to get on the Microsoft platform. Microsoft talked at the Samsung developer conference talking about xCloud and how they can reach so many more users through game streaming. Mixer is there as an easy to get to more users to use their service. Imagine watching someone play a game on Mixer and they want to invite you as you were talking to them in a chat, you can immediately play if you have Game Pass…but that's also a potential place to sell game pass as well. You see a game on Mixer and you are interested in playing it, there's a button that says "buy game pass and play this game instantly". That's what xCloud can do. That's why Google is also in this business. Streaming also allows Microsoft to compete with Apps Stores as well. You can buy a little game on the app/play store or you can use this subscription to play console like games. It's also a way for gamers to get into the Microsoft ecosystem. This streaming service can also be applied to Windows Mixed Reality and other VR/AR headsets. Phil does want it on every device.
Microsoft is increasing their studio output not only for having better exclusives, but to reach different niches in the market. They are no longer just focusing on the "big" mainstream games, they are trying to do what Netflix and Spotify do, get every type of content that people like, not just the popular ones and satisfy those users. If you satisfy enough niches, you get the entire market. That's why you will continue to see more studio acquisitions and that's why [email protected] is very important to them. A lot of those games are becoming games that launch on Xbox Game Pass. It's all about increasing the value of Xbox Game Pass and getting people on it. This gameplan that Microsoft has is to not win the "console war"…it's about getting gamers wherever they are in the world and monetizing them. Unlike Netflix and Spotify, gaming has a better model in which they can get more money from a user from a single game. Monetizing from DLC/MTX and letting users outright buy songs while also subscribing is more lucrative than only having a subscription. 100m subs = 1 billion in revenue in one month alone…but as I stated, that's just on subs, games can monetize even more. With the addressable market in the billions, you can see the potential to make a ridiculous amount of money. The lowest barrier to entry will get the most users.
That's why Satya believes in this endeavour and that's why Phil got on the executive leadership team because of the potential money.
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text:
> Wetenschap
Distribution of Bibenzyls, Prenyl Bibenzyls, Bis-bibenzyls, and Terpenoids in the Liverwort Genus Radula10.1021/acs.jnatprod.9b01132
Started by Phlogiston , Mar 13 2020 10:54 AM
#1 Phlogiston
poelitie
Posted 13 March 2020 - 10:54 AM
Link: https://pubs.acs.org...natprod.9b01132
Distribution of Bibenzyls, Prenyl Bibenzyls, Bis-bibenzyls, and Terpenoids in the Liverwort Genus Radula Abstract
Plants of the Radula genus are chemically very distinct from the other liverworts since they mainly elaborate bibenzyls including bibenzyl cannabinoids and prenyl bibenzyl derivatives, as well as bis-bibenzyls. Several of these components show biological activities such as psychoactivity, vasopressin antagonist, antimicrobial, antifungal, and NO production inhibitory activity, and cytotoxic activity against human cancer cell lines. While distribution of terpenoids in Radula species is in general very limited, some Portuguese species are rich sources of sesquiterpenoids. Among 679 liverwort species so far examined chemically, 264 species contained α-tocopherol, which may play an important antioxidative role for the constituents of oil bodies of liverworts
En vooral deze paragraaf trok mijn interesse;
One of the characteristic features of the genus Radula is the presence of bibenzyl cannabinoids in some of the species. The first example of the existence of such kind of compounds was the isolation of cis-perrottetinene (97) and perrottetinenic acid (98) from the New Zealand R. marginata Taylor.(6c) The Japanese R. perrottetii,(6b)R. campanigera, and R. chinensis,(8) the Costa Rican R. laxiramea Steph.,(13) and a Peruvian unidentified species also contained cis-perrottetinene (97).(9) Surprisingly, perrottetinenic acid (98) was isolated from the Japanese liverwort, Plagiochila ovalifolia Mitt., belonging to the Plagiochilaceae.(19)
The discovery of these bibenzyl cannabinoids (97 and 98) has attracted the attention of organic chemists, biochemists, and pharmacologists. Chicca et al.(20) published the review article entitled "Uncovering the Psychoactivity of a Cannabinoid from Liverworts Associated with a Legal High". in which the stereoselective total synthesis of cis- and trans-perrottetinene (97) were described and their in vitro pharmacology and tetrahydrocannabinoid (THC) isomers on cannabinoid receptors and endocannabinoid-degrading enzymes and in vivo pharmacology of cis- and trans-perrottetinenes were reported in detail. Both diastereomers of 97 readily penetrated the brain and induced hypothermia catalepsy, hypolocomotion, and analgesia in a CB1 receptor-dependent manner in mice, and cis-isomer interacts with major brain receptors, showing a selective cannabinoid pharmacology. Thus, cis-perrottetinene (97) found in several Radula species is a psychoactive cannabinoid.
Hussain et al.(21a, published two in-depth review articles entitled "Identification of Putative Precursor Genes for Biosynthesis of Cannabinoid-like Compounds in Radula marginata" and "Demystifying the Liverwort Radula marginata, a Critical Review" on its taxonomy, genetics, cannabinoid phytochemistry, and pharmacology. In these reviews, the authors detailed genetic and transcriptomic resources of R. marginata and pharmacological aspects of cis-perrottetinene as compared to Δ9-tetrahydrocannabinol. The reviews also included morphological aspects using colored pictures and electron microscopic features of R. marginata and its taxonomic, phytogeographic, physiological, anatomical, biosynthetic, symbiosis, and evolutionary aspects.
Drugs against War
... R.I.P. Toasted ...
Back to Wetenschap


text:
Q: Constructor not matched for class {proguard] I am enabling proguard in my application. Whenever I am building my application I am getting following error.
Constructor not matched for class com.acs.nomad.d.b.e
As Per my mapping file the class this is referring to is as below
package com.my.package;

import java.util.ArrayList;

import org.simpleframework.xml.ElementList;
import org.simpleframework.xml.Root;

@Root (name = "folders")
public class Folders
{
    @ElementList (entry = "contactFolder", required = false, inline = true)
    private ArrayList<ContactFolder> contactFolder;

    /**
     * List of contact folders
     */
    public ArrayList<ContactFolder> getContactFolder()
    {
        return contactFolder;
    }

}

I have tried all option as per these url
proguard-obfuscation-is-breaking
proguard-android-and-abstract-class-instantiation
android-proguard-and-keepclasseswithmembernames
Nothing seems to work. My Proguard.config file is
-optimizationpasses 5
-dontusemixedcaseclassnames
-dontskipnonpubliclibraryclasses
-dontpreverify
-verbose
-optimizations !code/simplification/arithmetic,!field/*,!class/merging/*
-keepattributes Signature, *Annotation*

-keep public class * extends android.app.Activity
-keep public class * extends android.app.Application
-keep public class * extends android.app.Service
-keep public class * extends android.content.BroadcastReceiver
-keep public class * extends android.content.ContentProvider
-keep public class * extends android.app.backup.BackupAgentHelper
-keep public class * extends android.preference.Preference
-keep public class com.android.vending.licensing.ILicensingService

-keepclasseswithmembernames class * {
    native <methods>;
}

-keepclasseswithmembers class * {
    public <init>(android.content.Context, android.util.AttributeSet);
}

-keepclasseswithmembers class * {
    public <init>(android.content.Context, android.util.AttributeSet, int);
}

-keepclassmembers class * extends android.app.Activity {
   public void *(android.view.View);
}

-keepclassmembers enum * {
    public static **[] values();
    public static ** valueOf(java.lang.String);
}

-keep class * implements android.os.Parcelable {
  public static final android.os.Parcelable$Creator *;
}

-keepclassmembers class * implements java.io.Serializable {
    static final long serialVersionUID;
    private static final java.io.ObjectStreamField[] serialPersistentFields;
    !static !transient <fields>;
    !private <fields>;
    !private <methods>;
    private void writeObject(java.io.ObjectOutputStream);
    private void readObject(java.io.ObjectInputStream);
    java.lang.Object writeReplace();
    java.lang.Object readResolve();
}

-keep public class org.simpleframework.**{ *; }
-keep class org.simpleframework.xml.**{ *; }
-keep class org.simpleframework.xml.core.**{ *; }
-keep class org.simpleframework.xml.util.**{ *; }

#Added commands
-assumenosideeffects class android.util.Log {
    public static int d(...);
    public static int v(...);
}

-keep class net.sqlcipher.** {
    *;
}

#dont warn for the android support version
-dontwarn android.support.**

# dont warn for google or framework related warning
-dontwarn com.google.**
-dontwarn org.simpleframework.**

#-dontshrink

-keepattributes ElementList, Root

-keepclassmembers class * {
    @org.simpleframework.xml.* *;
}

If you notice -dontshrink command is commented out. I want to shrink the apk so I don't want to run that command. Please also note that I am uncommenting -dontshrink command, it works.
Can anybody tell whats wrong?


text:
SportsHockeyIslanders
Defenseman Ryan Pulock making good on his potential for Islanders
Islanders defenseman Ryan Pulock skates with the puck against the Capitals in the first period of a game at Barclays Center on Monday, Dec. 11, 2017. Credit: Kathleen Malone-Van Dyke
By Arthur Staple arthur.staple@newsday.com Updated December 12, 2017 7:10 PM
Ryan Pulock has shown flashes of what he could be as a regular NHL defenseman before — Islanders fans will recall the work he did in the 2016 playoff series against the Panthers, when Pulock tallied three points in two games before being hurt.
But flashes are all anyone had seen until recently. The 6-foot-2, 225-pound defenseman seemed hesitant too often at either end of the ice.
Since he came back into the lineup on Dec. 1, however, Pulock is showing he was worth the wait. He only has one point in the last six games, but the 23-year-old has stepped up to play the sort of forceful game his coaches have wanted from him all season.
"Whether you're sitting out or you have a bad game, sometimes you make a decision. And it sounds so easy, but I think he just came in a few games ago and it was like, 'OK, that's the guy,'" coach Doug Weight said. "Quick hands, lugging the puck, stapling guys (to the wall) in his own zone. I think he fed off that."
Weight liked what he saw so much that he paired Pulock with Nick Leddy for two games while Johnny Boychuk sat out with a lower-body injury. The Islanders didn't win either one of those, in Pittsburgh and Boston, but Pulock more than held his own against the Penguins' high-end forwards and the Bruins' puck-possesion monsters on their top line.
Pulock has the best shots for/against percentage of any Islanders defenseman, with the Isles generating 51.5 percent of shots attempted with Pulock on the ice, according to Natural Stat Trick. That's not an overwhelming percentage, but it backs up what the coaches have seen: A more assertive player who's not afraid to unleash his 100-plus mph slap shot or use a fake to get open ice, as he did on Thursday when he walked around Sidney Crosby to set up Jordan Eberle's second-period goal.
Pulock's offense has never been an issue in three AHL seasons, where he scored 39 goals in 163 games. Weight has been happier with Pulock's defensive zone play more than anything at the other end of the ice.
"It started from his D, too — really exploding into players, using his big body," Weight said. "It's been really good in the D zone, assertive, good stick, making contact with people. He's been working a lot after practice on those things. He's feeling really confident defensively, it's transferred to his offense.
"When you look like him, 225, he's strong, a good skater, but his technique was poor. He's been working on it and now it's second nature for him. That's a credit to (assistant coach) Luke (Richardson), Cro (associate coach Greg Cronin) and Ryan."
By Arthur Staple arthur.staple@newsday.com
Arthur Staple was the Islanders beat writer. He was at Newsday from 1997 to 2018 and has covered hockey for more than a decade.
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text:
Home Latest FAO Impacts 400,000 Households in North-east
FAO Impacts 400,000 Households in North-east
Lai Mohammed
Hammed Shittu in Ilorin
Encomiums were at the weekend poured on the leader of the All Progressives Congress (APC) in Kwara State and Information and Culture Minister, Alhaji Lai Mohammed, over the celebration of his 68th birthday.
Kwara State Governor, Alhaji Abdulrahman Abdulrasaq, in his felicitation message in Ilorin to mark the birthday of Mohammed, prayed God to grant the celebrant long life and good health.
The statement, which was signed by the governor's Chief Press Secretary, Mr. Rafiu Ajakaye, said: "On behalf of the government and people of Kwara State, I congratulate a leader of our party the All Progressives Congress (APC), Alhaji Lai Mohammed, on this birthday anniversary.
"We acknowledge his various roles in the ascendancy of the APC in Nigeria and Kwara State and his continuous contributions to national development.
"We pray to Almighty God to grant him more rewarding years in the service of our state and Nigeria as a whole."
Also, the ruling APC in the state has lauded the minister for his steadfast and commitment towards the political development of the state and the country in general.
The party, in a statement by its state chairman, Hon. Bashr Bolarinwa, described Mohammed as a foremost nationalist, political galvaniser and dogged politician and strategist who would stop at nothing to achieve the collective goal for the benefit of mankind and the glorification of God.
"His (Mohammed's) love for the people was typified by the sacrifice, commitment and patronage dispensed by him to dislodge a political dynasty during the 2019 general elections in Kwara State.
"The pioneering efforts and sacrifice of our dear minister is noteworthy and indeed marked the watershed for our emphatic victory at the polls in the general elections earlier in the year.
"As he celebrates another birthday, I, personally, and on behalf of the Executive Committee of Kwara APC congratulate the Hon. Minister and wish him abundance of God's continued blessing in good health of body and mind," the statement said.
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I switched my blog over to the WordPress 2005-02-05 nightly and the cool thing this has is the blacklist feature. Any word that appears on that blacklist automatically causes the comment to be deleted. No notification e-mail, no moderation to deal with.
The reason I did this is that I was getting hundreds of "spam caught" e-mails per day using spam plugins. While on one hand it made me feel better that I could review deleted comments so none that were legiminate were deleted, it also clogged up my e-mail and wasted a lot of my team.
So what I did was put the blatant words that spammers use and that I know my site's visitors wouldn't use onto the blacklist. Words that a person might use in a comment that I have noticed spammers use, I put on the moderation list. I then turned off spaminator.
Since then, I have only gotten 10 moderation e-mails this past two days (which is down from 100s of spam deleted e-mails from spaminator). Those 10 moderated comments I took some more words from and put on the blacklist, so in the future that type of spam won't appear either on my blog.
Talk about making life easier. I went from 100s of e-mails to maybe 2 or 3 in the past 24 hours.


What's On | Children's Trail - fun for all the family!
Don't forget to ask for your free Children's Trail when you buy your Garden Tickets. Wander through the gardens, searching for all the items on the list and ticking them off...will you be able to find everything?!


text:
Barge haulers on the Volga
Ilya Efimovich Repin
Painting, 1873, 131×281 cm
Description of the artwork «Barge haulers on the Volga»
Picture "Barge haulers on the Volga" Repin wrote without reading Nekrasov's "Reflections at a main entrance". However, when I read, I criticized. Nekrasov:
Go out to the Volga, whose moan is heard
Over the great Russian river?
This moan we have a song called -
That twine haulers go!..
Repin assured that about any songs, even like a moan, the haulers do not have to think. "...no visit, to sing at the met; even on holidays, even the evening before the fire pot sullenness and anger seized them," – assured Repin. Indeed, looking at the boatmen in the painting, we don't really can imagine them singing the song, whether it's lyrical or accusatory.
The scope of the genre, everyday pictures too small for Repin. Do not get it, neither "household" nor incriminating picture. Although initially the plans were just like that. One day, while walking with friends on the Neva, Repin saw barge haulers, and he was deeply struck by the contrast between them and the idle aristocratic crowd. In 1870, the year with friends, the artist went on a trip on the Volga, where he worked on the sketches for the "Boatmen" (1, 2, 3, 4, 5).
"Boatmen" by Repin monumental, these dangling skinny people, it seems, the power and hopelessness of an entire people. Shining barge behind them – not just a ship with cargo, and that the world which after a while can no longer live in the old way. While symbolism as such are not fond of Repin. It haulers is exactly the boatmen, exhausted by pulling the strap guys. And dragging on their shoulders they are not allegory, but a real barge. Thus released from-under brushes of the artist, the picture is much grander than its original intent.
Shiny, almost festive landscape: Golden beach, clear sky, mirrored on the surface of the water in the distance is the ship. And, as if something alien – dark kicks from landscape chain boatmen. They seem to be a thing of another world. Boatmen from the depths of the canvas moving to the viewer. Their way is the plot. Can not see where they came from – they are the only shining landscape, he also found. And this is kind of inappropriate, weird and awkward chain of emaciated people moving through very bright, very festive for them the world.
"But what's that coming here? That dark, greasy, some brown stain that is creeping into the sun?" – Repin described his impressions from the first meeting with the haulers. He created his painting almost simultaneously with Savrasovym writing "Volga near Yuryevets". Both artists are that independent from each other engaged in a dialogue with "Barge Haulers" Vereshchagin.
The feature of the painting by Repin that the barge haulers in it's individualized, it's a separate people with its own history. Going ahead in the center is written from Kanina is a pop-defrocked and favorite Repin on the canvas. To the right of it – a huge man, embodies the wild, untamed force to the left – a sailor, hate glass eyes looking directly at the viewer. In the second triple stands out a very young boy, I think he's trying to remove the strap.
One of the conflicts Repin was that he was definitely an artist that expresses the aspirations of the public, the artist with citizenship and thus from time to time tried to follow the ideas of pure art and to protest against the publicistic artists of the Wanderers who strive to preach. In this sense, "barge haulers on the Volga" Repin unique: they are deprived of didactics, but "art for art's sake" is not exactly call them.
"Barge haulers, real barge haulers, and nothing more, – admired Dostoevsky. – None of them shouts from the painting to the viewer: "Look how unhappy I am, and to what extent you owe the people!"" How did you Repin to show the pathetic styling, but flesh and blood – and to do without teachings? A single imperative, which sets Repin: "Look!". But much of it not to avoid.
Repin picture at the annual academic exhibition, and even for the sake of completion put the training in Europe. "Barge haulers on the Volga" has caused a lot of attention and mixed reactions. Estimates ranged from "profanation of art" to "the greatest work".
Author: Alain Esaulova
I like39 To the selection66
Subject and objects: Genre scene
Technique: Oil
Materials: Canvas
Size: 131×281 cm
Location: State Russian Museum, Saint Petersburg
Artwork in selections: 66 selections
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