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Archive for the 'places' Category
1040 Fifth Avenue: Where Jackie O. lived
Posted in 1960s, 1970s, 1980s, 1990s, America, cribs, Jackie Kennedy, Jackie O, New York, places, upper east side on Wed Aug 27th 2008| 19 Comments »
I was getting a ton of hits for Caroline Kennedy because of the Democratic Convention, so I was going to do a post on her. Well, one thing led to another:
Jackie O. loved New York City. She wanted to bring up her children there. From 1964 to 1994 she lived on the 15th floor of 1040 Fifth Avenue on the Upper East Side of Manhattan. It is on the north-east corner of Fifth Avenue and 85th Street, across the street from Central Park and a block up from the Metropolitan Museum of Art.
A year after her husband, President John F. Kennedy, was shot dead she moved to New York to 1040 with her two little children, John, 4, and Caroline, 7.
She moved there because it was close to her sister Lee Radziwill and because she wanted Caroline to go to school at Sacred Heart on 91st Street, one of the best girls' schools in the city. She also knew that the Upper East Side would pretty much let her be. She went to mass at St Thomas More on 89th Street.
She bought the entire 15th floor in 1964 for $250,000 (200,000 crowns). In 1996, after she died, it was sold for $9.5 million (2 million crowns). In 2008 it sold for $19.5 million (1.5 million crowns). One of the later owners was the 33rd richest person in the world.
She filled the apartment with her books, her paintings and her art objects. She had a piano she could not play and a telescope which she used. She had no central air conditioning.
The place was friendly rather than grand. She wanted a private place for her family and friends to enjoy and feel at home in. It changed little over 30 years: "She was ageless and her style was ageless," her designer said about the place.
Because so many of her things were sold off after her death, hundreds of people own things that were once there.
With only two floors above it, it has a wonderful view of Central Park: you can see the Reservoir, now named after her, and the 3,400-year-old Temple of Dendur, which she had helped to bring to the Met museum from Egypt. The 15th floor has a terrace where you can step outside and take in the view.
From 1996 to 2000 much of the 15th floor was rebuilt and the layout changed somewhat.
In 2006 the 15th floor had:
Facing Central Park:
library (with fireplace)
living room (with fireplace)
dining room (with fireplace)
four bedrooms in all
three terraces in all
two dressing rooms
a staff room
five and a half bathrooms
a wine room
a gallery
a chef's kitchen
a laundry room
a cloak room
The building went up in 1930, done in a neo-Classical style. It was designed by Rosario Candela, who did many luxury apartments in the city in the 1920s and 1930s. The roofline is pretty strange and sets it apart. The building has 17 floors and only 27 apartments.
The building has a doorman but no garage or health club.
Jackie's Apartment – has good pictures and the 2000 floor plan
Caroline Kennedy – Jackie's daughter, who grew up there
Jamaica, Queens
Posted in America, New York, places on Tue Mar 18th 2008| 4 Comments »
Jamaica, Queens, "the other Jamaica", is in the south-east part of New York City, just north of the JFK airport. It is not named after the island: it was once called Jameco. This unsung corner of the city has given us Assata Shakur, Sean Bell, 50 Cent, Q-Tip, the singer Olivia, governor Mario Cuomo and others.
It is one of the three main black parts of New York City, the other two being Harlem and the part of Brooklyn centred on Bedford-Stuyvesant. Jamaica is more middle-class and less famous than the other two.
In the 1950s Jamaica was almost all white. In the 1960s blacks started moving in from the American South – and whites started to move out. In the 1980s West Indians and Latin Americans started coming. Since the late 1990s it has been Asians, especially Bangladeshis.
It is about 45 minutes east of Manhattan by train. There are some high-rise apartment buildings but it is mainly street after street of houses and shops, few with more than two floors.
Jamaica Avenue is the main street.
Hillside Avenue, a few blocks north, is the colour line: to the south Jamaica is mainly black, to the north it is mainly not.
North of Hillside and to the east is Jamaica Estates. It is white and well-to-do. To the west of it are foreign-born whites and Asians, a place where taxi drivers and hot dog sellers live. Part of the plot to destroy the World Trade Center in 1993 took place there.
Middle-class white Americans are seen mainly far to the north near St John's University.
South Jamaica, to the south of Hillside, stands at the head of a black middle-class region that extends east into Hollis, Queens and beyond into Long Island. The blacks in Queens are richer than the whites.
Black Jamaica is more middle-class than Harlem, but it is also more violent. This was especially true in the 1980s and early 1990s when crack was at its height.
In the 1980s the great and good of the city pushed the drug trade from other parts of the city into south Jamaica. They let the drug lords shoot it out among themselves on its streets. The sound of gunfire and ambulances were a fact of life. Even walking to school could be dangerous.
Young men died in their hundreds every year. The city and the country did not care. Not, that is, till one day when a white policeman was shot dead. Then suddenly the violence was unacceptable. But after the speeches were made and the news men went away, the violence carried on. This was where 50 Cent was shot in 2000 and where Sean Bell was shot 50 times by the police in 2006.
In the 1990s it become much safer: the murder rate dropped by half, as it did in much of the city.
I lived there from 1986 to 1993. They had a wonderful library on Merrick Boulevard. I loved it. Its librarians deserve as much credit as my teachers for making me who I am.
South-east corner of Hillside Ave and 162nd St (Google Maps Street View)
YouTube: Method Man, D'Angelo – Break Ups 2 Make Ups – this video seems to have been shot in Jamaica, Queens.
Those who have lived there:
Sean Bell
Vanessa Simmons
Abagond (me)
Assata Shakur
The Delaware – the people who lived there first and gave it its name: Jameco (it means "beaver").
black ghetto
The black middle class in America
Jamaica – the island
Tick Tock Diner
Posted in 1940s, 1948, America, new jersey, places on Fri Mar 14th 2008| 3 Comments »
The Tick Tock Diner (1948- ), "the King of the New Jersey Diners", is a northern New Jersey landmark. It is an all-night place to eat on Route 3, one of the main road that head west from New York City. Jean Shepherd used to talk about it on his old radio show. He liked the sign in front that says "Eat heavy."
There is a Tick Tock diner in New York City too. That is a different diner.
Its busiest time is from midnight to three in the morning, when party-goers are on their way home from New York and need a bite to eat. It is just down the road from the Meadowlands, the vast swamp where Giants Stadium stands, so it gets people coming back from a game too.
Because it stands near a crossroads it gets all sorts of people. Those who want or hold public office see it as a place to go to meet "the people". Chelsea Clinton and Governor Corzine were both there in February 2008.
I see it every day on the way home from New York. But I never ate there till this week. We went at ten on a Wednesday night (March 12th 2008).
From the road it is very noticeable, so when you walk inside it seems smaller than you expect. And nicer too. So nice that while Verizon used the outside of the diner in a 2008 television ad, it did not use the inside. (It is the ad where a man is trying to use his daughter's pink mobile phone.)
The food is good. Much better than what you get at IHOP, Bob Evans or any of those other roadside places that serve homestyle cooking. It is not as good as, say, Red Lobster or Ruby Tuesday, but the food seems more like home cooking. It is way better than White Castle.
The servings are large, larger than you get at most places, which is nice.
Our waitress was very nice. (No, my cousin does not work there. This is not that sort of review.)
It seems like a great place to eat with friends or family, but not a place to bring a date. It is nice, but not that nice.
The cost: A big dinner for a family of four – we ordered so much food that we were all stuffed and had to take some home – cost us $72.60 (four crowns). Not bad at all for what you get.
I had the soup of the day, a Black Jack Burger, fries with gravy, a chocolate shake, tea and a brownie with vanilla ice cream and chocolate syrup. All great stuff. Even the tea was good.
The diner was built by Kullman, who built other diners too. It does have that Jersey diner look to it. But it has been built and rebuilt over the years. Only the clock and maybe part of the sign are from the old days.
Posted in 1700s, America, buildings, cribs, places, thomas jefferson, virginia on Thu Nov 30th 2006| 1 Comment »
Monticello (1768- ) is the house of Thomas Jefferson, the third American president. It is in Virginia near Charlottesville on the top of a "little mountain" (what Monticello means in Italian). It is the house you see on the back of nickels (the American five-cent coin). What you do not see on the nickel is the wonderful view it has.
Jefferson and his friend Dabney Carr went to the top of the mountain as boys. They promised each other that they would be buried under an oak tree there (they were). Jefferson liked the place so much that he built his house there, amid the oaks.
Jefferson designed the house in 1768. From then till 1809 he, his white workers and black slaves worked on it. It seems he was always working on it. When Jefferson left for Europe in 1784 the house was more or less done, but his five years in Europe gave him new ideas. When he got back he tore down a lot of it and rebuilt it.
The house is Italian on the outside in the style of Palladio and English on the inside. The cooking was French.
Apart from the windows from Europe, the house is mostly built from materials from the mountain itself.
The estate had about 2000 hectares and 150 slaves, including Sally Hemings.
The dome, the rounded part of the roof, was not added till 1800. It is a lot more evident on the nickel than it is in real life when you are on the ground looking up at it. When you enter the house you have no idea that it is there. (I was there in 2006.)
When you walk in you come into a waiting area. Above the door is a clock that tells not only the hour and minute but also the day of the week. While you wait you can look at the bones of monstrous creatures that once lived there in a lost age.
His book room held thousands of books. Most of the books you see are copies of the books it once had. The originals were sold off long ago to help settle Jefferson's debts. A few books, though, are left: the Don Quixote that he learned Spanish from, his Ariosto, Virgil, Plutarch and some others. He has a lot of law books and books in French.
Next to his library is his office and next to that his bed, which seems too short (as do others from that period).
There is an eight-sided room where James Madison and his wife often slept. The bed is set in the wall in the French style of the time.
The house is full of paintings, clocks, fireplaces and windows – but not many curtains! On the wall of his living room are paintings of his three heroes: Newton, Bacon and Locke.
The steps going up to the second floor are very narrow – to save space in the house. They let people see the second floor only two nights a week. You have to sign up on the Internet for it.
Sally Hemings
Jefferson's library


text:
Faxonius obscurus is a species of crayfish in the family Cambaridae. It is native to the northeastern United States, where it occurs in Maryland, New York, Ohio, Pennsylvania, Virginia, and West Virginia. It is an introduced species in adjacent regions, including Massachusetts, Vermont, and Ontario in Canada. It is known commonly as the Allegheny crayfish and the obscure crayfish.

This species lives in slow-moving waterways and pools with rocky substrates, where it hides beneath rocks. It also burrows into the substrate.

This species is common to abundant. It faces minor threats in some parts of its range. It has been displaced by the rusty crayfish, a related species that is more aggressive and outcompetes other crayfish in its habitat. Other threats include water pollution, especially from mine runoff.

It has become an introduced species itself in some areas, often when released from bait buckets.

References

Cambaridae
Crustaceans
Crustaceans described in 1870
Taxa named by Hermann August Hagen
Taxobox binomials not recognized by IUCN

redpajama_set_name: RedPajamaWikipedia


CLEVELAND – The University of Chicago men's tennis team absorbed its first loss of the season to Emory University 5-1 in the final of the ITA Division III National Team Indoor Championship on Sunday morning.
The No. 5-ranked Maroons moved to 9-1 on the season and replicated their second-place finish at ITA Indoors for the second year in-a-row. The No. 2-ranked Eagles improved to 5-2.
In a rematch of last year's ITA Indoor final, UChicago fell behind 3-0 after doubles and wasn't able to recover the momentum. Junior Nicolas Chua claimed a win at No. 2 singles by scores of 7-5, 6-2. The dual was played to decision once Emory captured the clinching fifth team point.
"We have to credit Emory in this match," said Head Coach Jay Tee. "They're a championship program that knows what it takes to win titles. We played hard today and we are starting to establish ourselves as a premier program, but we need to continue learning what it means to play at a championship level and to take that next step. This loss stings a little bit because we thought we had closed that gap since last year, but it's apparent that we have quite a bit of improvement left to make."


text:
Generation Entrepreneur
Released on 2000 by Stuart Crainer
Author: Stuart Crainer
Publisher: FT Press
Something has changed the business world. Big business has lost its allure for the new generation. Where once youthful employees pursued corporate goals, generation entrepreneur dream their own dreams. Corporate man is dead. Long live generation entrepreneur This is the age of the entrepreneur. What began in Silicon Valley as a dream for a select few has become a worldwide phenomenon. For growing numbers of young business people, creating a business has become a calling, a vocation, a mission. They are what they do, and they do what they are. Above all, they do their own thing. Meet the new wealth creators and read the handbook for a new business generation.
Family Entrepreneurship
Released on 2021-04-05 by Matt R. Allen
Author: Matt R. Allen
This book provides recent ideas, insights, facts, evidence, frameworks, and perspectives on how and why entrepreneurial families are successful over generations. The book focuses on how families successfully implement entrepreneurship across generations. That success, it argues, requires entrepreneurship at the level of the family, not only in the businesses the family owns and manages. Written by noted academics and consultants who are authorities on family entrepreneurship, the chapters provide a comprehensive exploration of the characteristics of successful entrepreneurial families, their motivations, how they behave over time, and, suggestions for how business families can encourage and sustain entrepreneurship. This comprehensive look at family entrepreneurship will serve as a fundamental reference text for family business consultants, owners, and scholars.
Oswaal CBSE Chapterwise & Topicwise Question Bank Class 11 Entrepreneurship Book (For 2022-23 Exam)
Released on 2022-07-01 by Oswaal Editorial Board
Author: Oswaal Editorial Board
Publisher: Oswaal Books and Learning Private Limited
Category: Study Aids
Chapter Navigation Tools • CBSE Syllabus : Strictly as per the latest CBSE Syllabus dated: April 21, 2022 Cir. No. Acad-48/2022 Latest Updations: 1. All new topics/concepts/chapters were included as per the latest curriculum. 2. Self Assessment papers for practice • Revision Notes: Chapter wise & Topic wise • Exam Questions: Includes Previous Years KVS exam questions • New Typology of Questions: MCQs, VSA,SA & LA including case based questions • NCERT Corner: Fully Solved Textbook Questions (Exemplar Questions in Physics, Chemistry, Biology) Exam Oriented Prep Tools • Commonly Made Errors & Answering Tips to avoid errors and score improvement • Mind Maps for quick learning • Concept Videos for blended learning • Academically Important (AI) look out for highly expected questions for the upcoming exams • Mnemonics for better memorisation • Self Assessment Papers Unit wise test for self preparation
Entrepreneurship in Context
Released on 2012-03-15 by Marco van Gelderen
Author: Marco van Gelderen
Much research in entrepreneurship presents results as if they are universally and timelessly valid. Entrepreneurship in Context takes the opposite tack – it studies entrepreneurship as a context bound phenomenon. For entrepreneurship, the importance of context goes beyond gaining understanding and avoiding mistakes. The reciprocal influence exercised by the entrepreneurial venture and its corresponding context is at the very heart of the entrepreneur as an agent of change. The book addresses context in a narrow sense, i.e. a person's life situation and local, situational characteristics. It also deals with wider contexts such as social, industry, cultural, ethnic, sustainability-related, institutional, and historical contexts. The book studies the interconnectedness of all these various sub-contexts. It zooms in on the actions that entrepreneurs take to involve, engage, and influence their context and shows the changing and dynamic nature of context. It provides lessons for entrepreneurs about which contextual elements should be prioritized, engaged and sought out.
Diasporas and Transnational Entrepreneurship in Global Contexts
Released on 2016-12-28 by Ojo, Sanya
Author: Ojo, Sanya
Publisher: IGI Global
The advancement and progression of migrant businesses has increased significantly in the globalized modern society. As such, current research has emerged regarding the characteristics of transnational economic activities. Diasporas and Transnational Entrepreneurship in Global Contexts is an essential reference publication for the latest material on the nature, process, and outcome of migrant entrepreneurs' economic activities expanding from their countries of origin to their countries of residence. Featuring coverage on a broad range of topics, such as regional growth, industrial development, and employment generation, this book is ideally designed for researchers, advanced-level students, practitioners, managers, and policy-makers seeking current research on how economic development can be encouraged and nurtured among ethnic entrepreneurs and businesses.
Comparative Case Studies on Entrepreneurship in Developed and Developing Countries
Released on 2015-01-31 by Ofori-Dankwa, Joseph
Author: Ofori-Dankwa, Joseph
Lauded as a driver of economic growth, entrepreneurship and small business ventures have become increasingly attractive to countries looking to boost employment rates, productivity, and innovation. The manifestation of entrepreneurship varies from country to country, and what works for one may not work for the next. Comparative Case Studies on Entrepreneurship in Developed and Developing Countries presents the challenges and opportunities that entrepreneurs in different countries face at various developmental stages. Through in-depth studies, this premier reference work seeks to provide examples of successful applications of an elusive concept that has helped many countries move up the developmental ladder, a topic relevant to researchers and academicians working in social and behavioral sciences, economists, and business professionals.
Entrepreneurship Class XI (English) Poonam Gandhi 2021-2022
Released on 2021-07-02 by VK Global Publications Pvt Ltd
Author: VK Global Publications Pvt Ltd
Publisher: VK Global Publications
From the publisher VK global publications Pvt. limited Is a household name now. Established in 1979, with more than three decades of leadership in the area of economics and commerce, we take pride in claiming that we continue with the unstirred readership in the country. Specialising in the area of economics and commerce, we are not averse to the idea of diversification. Keeping this in view, more than a decade ago, a series of 'exam idea' Was launched in all the subjects For classes IX -XII however, success of our publication is admittedly due to prudent prolific writers. We have resource-pool of reputed authors, who leave no stone unturned in bringing out the best of study material, which makes our readers versatile in their thought processes and equips them with the exam-oriented acumen. Thousands of acknowledgment and accolades that we receive every year from our readers are a good testimony to the efforts and trustworthy endeavours of our authors the book has been designed topic and subtopic-wise, keeping the students' needs in mind.
European Entrepreneurship Research and Practice
Released on 2020-03-01 by Massimiliano Pellegrini
Author: Massimiliano Pellegrini
Publisher: IAP
The tradition of European scholars on entrepreneurship has been consolidated during the last three decades and an increasingly distinct European school of thought has emerged as a consequence. This development provides as solid base for the future development of the field where Europe and its entrepreneurship scholars will play an increasingly prominent role in the development of the field. The distinct focus of the book is key European features – 'contexts matter' – to promote and stimulate what 'European' might mean in any given context. The book valorizes different contexts and key strengths of the European perspective.
Released on by Dr. J.D. Wadate I Er. Rahul Wadichar I Dr. Mukul Burghate
Author: Dr. J.D. Wadate I Er. Rahul Wadichar I Dr. Mukul Burghate
Publisher: mukul burghate
Category: Antiques & Collectibles
Entrepreneurship is a discipline with a knowledge base theory. It is an outcome of complex socio-economic, psychological, technological, legal and other factors. It is a dynamic and risky process. It involves a fusion of capital, technology and human talent. Entrepreneurship is equally applicable to big and small businesses, to economic and non-economic activities. Entrepreneurship lies more in the ability to minimize the use of resources and put them to maximum advantage. Without any awareness of quality and desire for excellence, consumer acceptance cannot be achieved and sustained. Above all, entrepreneurship today is the product of teamwork and the ability to create, build and work as a team. The entrepreneur is the maestro of the business orchestra, wielding his baton to which the band is played. It is in this context, a study Material on introduction to the subject 'Entrepreneurship Development' is presented to the students of Professional Post-Graduate MBA degree. The book contains the syllabus from basics of the subjects going into the intricacies of the subjects. All the concepts have been explained with relevant examples and diagrams to make it interesting for the readers. An attempt is made here by the authors to assist the students by way of providing Study Material as per the curriculum with non-commercial considerations. However, it is implicit that these are exam-oriented Study Material and students are advised to attend regular class room classes in the Institute and utilize reference books available in the library for In-depth knowledge. We owe to many websites and their free contents; we would like to specially acknowledge contents of website www.wikipedia.com and various authors whose writings formed the basis for this book. We acknowledge our thanks to them. At the end we would like to say that there is always a room for improvement in whatever we do. We would appreciate any suggestions regarding this study material from the readers so that the contents can be made more interesting and meaningful. Readers can email their queries and doubts to our authors on [email protected] We shall be glad to help you immediately. Sr. J.D .Wadate I Er. Rahul K. Wadichar I Dr. Mukul Burghate Authors
Gen E
Released on 1999 by Brian O'Connell
Author: Brian O'Connell
ISBN: PSU:000045014925
Argues that Generation X enterepreneurs are different from entrepreneurs of previous generations, describes the challenges they face, and shares advice from fellow entrepreneurs
A Text Book Of Artificial Intelligence For Class XII
Released on 2021-08-01 by Hema Dhingra
Author: Hema Dhingra
Publisher: Goyal Brothers Prakashan
Category: Juvenile Nonfiction
Goyal Brothers Prakashan
BASICS OF ENTREPRENEURSHIP DEVELOPMENT
Released on by Dr. Haridas Jogdankar
Author: Dr. Haridas Jogdankar

redpajama_set_name: RedPajamaCommonCrawl


An ordinary person, especially a man: "In these films the art community is a netherworld aggressively hostile to those average joes ... who are not of it" (Carrie Rickey).
Eubank was quoted as saying by boxnationtv's Twitter account after his win over Siala: "The main fight is on the 29th against average Joe.
We keep hearing the recession is over but for the average Joe it's still a daily struggle to get by.
In the pharmaceutical sector, for example, Merck is a Miracle Worker, Eli Lilly is a Long Runner, and KV Pharmaceutical is an Average Joe.
It's the story of an average Joe who makes it possible for thousands of other average Joes to become everyday heroes in their own right.
What I think we are unlikely to see again is the opportunist average Joe carrying out criminal acts under the mistaken belief that there would be no consequences.
The average Joe who goes to work in a morning to earn a crust and pay his council tax in the vague hope someone might come along and collect their rubbish now and again.
Tell 'em where to stick their bins!
The big question is this: Do the customers of the water district want the average Joe and Jane making critical decisions about the future of the district?
I I'm intrigued by the new Humminbirds and 3-D color monitors, but don't know how important these features are for an average Joe like me.
Since these aren't photos of scarce antiques priced way beyond the reach of the average Joe, the possibility remains compelling that we may one day become the proud owners of at least some of these blackpowder beauties.
With plenty of ideas and advice for even the most slovenly average Joe, "How to Get Hot Women Into Bed" is worth reading for anyone who wants to turn their luck around.
How are Average Joe supporters like me supposed to pay that?
A Hydratrek LLC spokesman says the aluminum clad vehicle is suited for a range of missions that span disaster response, emergency rescue, law enforcement, environmental research, geological surveying and, for the average Joe, hunting and fishing.


I have always been fascinated by Susan Sontag. I envied her seeming crystal-sharp intelligence, her confidence in her opinions, her strength in writing, her omnivorous reading. While I certainly have not read everything of hers, I have read quite a lot. Once as a reader for The Franklin Library's First Editions, I read the galleys of The Volcano Lover, her historical novel about the triangle between Sir William Hamilton, his wife Emma and Lord Nelson. It was the first piece of fiction of hers I had read. Like all of her writing it was intelligent, sharp and incisive. And it had a truth that can only be found in fiction. Her following novel, In America, was not as satisfying for me–it seemed undone. Or perhaps overdone, might be a better word, for the brilliant characters and storyline are over-examined and over analyzed as if Henry James were writing the screenplays for MadMan. The novel is crushed by the intelligence.
However, I have read much of her non-fiction: Against Interpretation and Other Essays (1966), On Photography (1977), Illness as Metaphor and AIDS and Its Metaphors (1978 and 1988) and Regarding the Pain of Others (2003). (The Illness as Metaphor book was revamped in 1988 in order to address the scourge that was AIDS in the 1980's.) It is this non-fiction, her essays that make her an major figure of the late 20th-century. It is in these essays that the true brilliance shines. Hers is a hard intelligence, but a very clear intelligence. Her Against Interpretation gave readers an argument "against what something means" and for "what something is." It includes insightful–and new–readings of Sartre, of Beckett, of Bresson, among others. Illness as Metaphor moves us from the tuberculosis and consumption that affected so many of the 19th century's literary characters and creators to the cancer that became the overriding metaphor of the twentieth. On Photography discusses the relatively new art of photography–only since the mid-19th century– in a way that will change how even the most amateur viewer–myself– views photographs again. And at the beginning of the second Iraq war, I once gave a section of Regarding the Pain of Others to a class of 18-year olds, and it surprised me how well it worked with theml.
A few years ago, I went to the Brooklyn Art Museum to see a photographic exhibit on Sontag by Annie Liebovitz, perhaps America's most famous and celebrated portraitist at the time. Liebovitz–who had had a decades long romantic relationship with Sontag–captured Sontag's final years, among family and friends. Many of them were during her final days, during her final battle with cancer. To this day I don't know if I am more affected by the words Sontag wrote or the images of her that I saw that day. Both, suggest an admirable toughness and wit.
What I also don't know is why today, the NYTimes decided to publish a sampler of Sontag's work in the Week in Review section of the Sunday paper. There is no anniversary that I know of. It just appeared. But good, it made for a good read on a Sunday morning, and a good afternoon going through some old books. The excerpts are just that–excerpts–but they show the range, the depth and the honesty of her writing and her mind. The article is below: enjoy it.
People say "it's boring" — as if that were a final standard of appeal, and no work of art had the right to bore us. But most of the interesting art of our time is boring.
Jasper Johns is boring. Beckett is boring, Robbe-Grillet is boring. Etc. Etc.
Maybe art has to be boring, now. (This doesn't mean that boring art is necessarily good — obviously.) We should not expect art to entertain or divert anymore. At least, not high art. Boredom is a function of attention. We are learning new modes of attention — say, favoring the ear more than the eye — but so long as we work within the old attention-frame we find X boring … e.g. listening for sense rather than sound (being too message-oriented).
If we become bored, we should ask if we are operating in the right frame of attention. Or — maybe we are operating in one right frame, where we should be operating in two simultaneously, thus halving the load on each (as sense and sound).
There is no one right way to experience what I've written.
But that doesn't mean "I" "really" "think" that. It only means that is my-thought-when-writing (or when- talking). If I'd written another day, or in another conversation, "I" might have "thought" differently.
Being in love (l'amour fou) a pathological variant of loving. Being in love = addiction, obsession, exclusion of others, insatiable demand for presence, paralysis of other interests and activities. A disease of love, a fever (therefore exalting). One "falls" in love. But this is one disease which, if one must have it, is better to have often rather than infrequently. It's less mad to fall in love often (less inaccurate for there are many wonderful people in the world) than only two or three times in one's life. Or maybe it's better always to be in love with several people at any given time.
Things I like: fires, Venice, tequila, sunsets, babies, silent films, heights, coarse salt, top hats, large long- haired dogs, ship models, cinnamon, goose down quilts, pocket watches, the smell of newly mown grass, linen, Bach, Louis XIII furniture, sushi, microscopes, large rooms, boots, drinking water, maple sugar candy.
Things I like: ivory, sweaters, architectural drawings, urinating, pizza (the Roman bread), staying in hotels, paper clips, the color blue, leather belts, making lists, wagon-lits, paying bills, caves, watching ice-skating, asking questions, taking taxis, Benin art, green apples, office furniture, Jews, eucalyptus trees, penknives, aphorisms, hands.
This material is excerpted and adapted from the forthcoming book "As Consciousness Is Harnessed to Flesh: Journals and Notebooks, 1964-1980," by Susan Sontag, edited by David Rieff. A version of this was originally published in the NEW YORK TIMES, April 1, 2012.
Thank you for posting this article John.
And I am not only reading, I am also thinking of what you say and enjoying, so the reward is even bigger.


text:
require 'webrick'
require 'stringio'
require 'logger'
require 'optparse'

class FortuneServlet < WEBrick::HTTPServlet::AbstractServlet
  def do_GET(request, response)
    response.status = 200
    response['Content-Type'] = 'text/plain'
    response.body = get_fortune
  end

  def get_fortune
    out = StringIO.new
    IO.popen(@@command) { |f| f.each_line { |l| out << l } }
    return out.string
  end

  def FortuneServlet.set_fortune_command(command)
    @@command = command
  end
end

#FortuneServlet.set_fortune_command('/opt/local/bin/fortune -s')
FortuneServlet.set_fortune_command('/usr/bin/fortune -s')

port = '8080'
opts = OptionParser.new
opts.on('-c COMMAND', 'Use this fortune command') do |val|
  FortuneServlet.set_fortune_command(val)
end
opts.on('-p PORT', 'Use this port') { |val| port = val }
opts.on('-h', '--help', 'Show this message') do
  puts opts
  exit
end
opts.parse(ARGV)
opts = nil

null_logger = Logger.new('/dev/null')
config = {
  :BindAddress => '127.0.0.1',
  :Port => port,
  :Logger => null_logger,
  :AccessLog => null_logger
}
server = WEBrick::HTTPServer.new(config)
server.mount("/", FortuneServlet)

# trap signals to invoke the shutdown procedure cleanly
['INT', 'TERM'].each { |signal| trap(signal){ server.shutdown } }

server.start

redpajama_set_name: RedPajamaGithub


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Home Article A dramatic win for England
A dramatic win for England
WORLD Cup 2019 ended with the most interesting and nerve shredding final between England and New Zealand. In a dramatic way, England won the World Cup for the first time but it was the game that will be remembered by the cricketing fans and gurus for a long time to come.
The people would not have enjoyed such a final ever before. It indeed was the game at its best with nerves running high not only of those playing in the ground but also the cricket fans. Anyway as the World Cup is over, it is time for the International Cricket Council to review some of its rules for a better future of the game. World Cup is held every four years and it is a lifetime opportunity for many players. Therefore, the current format in which one team played against all the other contesting teams is something that the ICC should persist with. However, there is need to bring improvement in some other areas. Such as instead of Super Over, there should be a Super Game of three to five years if a match ties in such a mega contest. There may be a super over in case the match ties after this Super Game. In fact this will leave with little probability of a tie, and even if the match ties after the Super Over, then both the teams should be declared the winner in case it is the final of a mega event. Declaring a team winner on the basis of mere hitting more boundaries as has happened in the final between England and New Zealand is something that is not digestible for the cricketing fans. This time, many of the World Cup matches were washed away by the rain. To avoid this, matches can be conducted under covers. Then there is also need to improve the standards of umpiring with more use of technology.
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India and security of South Asian States | By Dr Muhammad Khan
Health as a multidimensional phenomenon | By Dr Ibad Ullah Sajid
Zero waste lifestyles | By Rimsha Malik
Copa del Rey: Real Madrid overcome Atletico to reach semi-final January 27, 2023


GEPR (Global Energy Policy Research) is a "virtual think tank" on web, a research institute that aims to study energy policies deeply and impartially, and make a proposal to the society. The institute is operated by Agora Incorporated ( Tokyo), conducting research and survey on energy issues, provide information on internet, hold symposiums, create proposals, and publication of books.
GEPR aims to create a place for high quality debate, where experts and citizens of the world with various standpoints can discuss. This site has mainly two functions; contribution by experts on energy issues, and database of important information. This discussion, we believe, will provide an important tip when considering the future of energy issues of Japan, and of the world.
Japan faced tragedies, the East Japan Earthquake of March 11th 2011, which followed by the accident at the nuclear power plant owned by the Tokyo Electronic Power Company (TEPCO), in Fukushima. Failure of power facilities in stricken areas resulted in energy source shortage of electricity, gasoline and so on in stricken area and entire east Japan. Rights and wrongs of nuclear power generation and implementation of renewable energy as alternatives had been actively discussed.
Hence, Japan is been forced to approach a solution on various issues such as overcoming vulnerability of energy supply system, introduction of renewable energy, safety of nuclear energy and so on. What is necessary here, are accurate and meaningful information. GEPR hopes to be the place for accumulation of this information. We believe the experience of Japan would be useful when other countries facing energy related problems need to solve those issues.
We hope for and appreciate your cooperation and support.


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Abang Ashu Academy (3A)
Abang Ashu Academy (3A) is a charity in Cameroon committed to the provision of humanitarian relief and development assistance to communities in crisis. 3A focuses on help for under-privileged girls and boys, widows, aging persons, handicapped persons, pregnant women, mothers and children in need. ...
Global Welfare Organization (GLOWA) is a Cameroonian NGO that is dedicated to upholding the rights of children through education and training. GLOWA is active in combatting child trafficking and the damage it does in communities throughout the Northwest Region using varied approaches that range...
Transform Youths Life Foundation
Transform Youths Life Foundation is a Christian NGO in Malawi. The Foundation works with children in remote areas, encouraging them to go back to school.
Roma orphans and vulnerable children's care ( Roma Ovc Care )
Roma Ovc Care is a non – profit making Organization which was established in 2015 in Ndola District of Copperbelt Province of the Republic Of Zambia. The project focuses on providing holistic care and support to vulnerable populations especially children and elimination of all forms of child abuse...
Lighthouse is a nonprofit organization established in 2013 and has been serving areas of extreme poverty in rural Zimbabwe. Lighthouse is registered as a private voluntary organization (PVO) in Zimbabwe. Lighthouse works to provide holistic work to the abject poor through the rural communities...
UNCAGED's focus is on the tremendous and complex task of rescuing and restoring shattered hearts, minds, and psyches. The goal is to become one of the world's leading catalysts and resource hubs for the anti-trafficking movement. Current operations take place in Romania. Our mission is to...
Save the Poor International (SPI) NGO
Save the Poor International (SPI), is a charitable entity, a non-profit, non-political and a non-governmental organization (NGO) legally registered with these government agencies; the Registrar General's Department and the Department of Social Welfare in the Republic of Ghana. As one of the most...
Orion Learning Centre
Orion Learning Centre was set up to bring education to poor families from especially secondary school students from form 1 to form 4. The Centre also aims to go and collect students from poor families and bring them to the school and to give them better education by considering their needs. The...
PureTrust Foundation LBG
PureTrust Foundation LBG is an integrated service, advocacy and Community Foundations Development NGO established in Tamale Ghana, on June 2014 by nine local leaders. The vision of this foundation is to promote community action for the cause of equitable inclusive society in Ghana. Its mission is...
Omuto Foundation Limited
Omuto Foundation is a charitable non-profit company, (Reg. No. 80020003361632) aiming to have a big impact on the lives of the marginalized children; as we devise ways to fight child poverty, promote young talents, uphold children rights and bring about sustainability in Uganda Core Program...
Community Support Center / CSC-Asbl
Community Support Center / CSC-Asbl is a non-profit organization founded on February 23 and registered at Local / Provincial level on May 17, 2016 under the number below: 112 / SKV / 6296. The Mission is to provide support, supervision and psychosocial support to children and young women and...
The Mawoudit Foundation (MF-SS)
THE MAWOUDIT FOUNDATION is a non-governmental, non-political and non-profitable organization founded in 2018 to promote girl-child education, Advocating for environmental protection, Renewable energy, providing sports clothes, scholarship, child sponsorship, and helping poor people in South Sudan.
OCIA
OCIA is a multi-layered non-profit organization focused to ensure that adequate care and support are provided to both orphans and vulnerable children abandoned by parents and families. OCIA assists such children to be educated and trained so as to be successful and useful members who can contribute...
Societal Aid Foundation Outreach
Society Aid Foundation Outreach was set up with the objective to create a future where opportunities, dreams, goals and aspirations are ushered in recognition of wide development that exists within societies. It works to bridge this gap by harnessing the energy and resources of some of...
Keystone Moldova
Keystone Moldova is an NGO working to create opportunities where people can grow, exercise self-determination, and participate in and contribute as valued members of their society. The Association provides direct services and best-practice training to further the independence of children and...
Volunteer Nepal National Group (VolNepal)
Volunteer Nepal is a local independent NGO based in Kathmandu. The organisation aims to implement new initiatives to answer the need for communication between volunteers and community groups with NGOs operating both locally and internationally.
Global Aid Network - GAiN Germany
GAiN exists to demonstrate the love of God, in word and deed, to hurting and needy people around the world through relief and development projects. Whatever the need, be it food, shelter, medical supplies or development assistance, GAiN innovatively links individuals and groups worldwide, sourcing...
Comité d'Entraide Familiale(CEF,Asbl)
The motivations were not only those of the consideration of their state of poverty caused by the repeated tribal wars of 1996, 1998 and its multiple effects which destroyed the economic, environmental and human fabrics. But also the massive return, that is to say voluntary repatriation of Congolese...
LGBT Voice Tanzania
LGBT Voice Tanzania is a non-profit organisation in Tanzania promoting the rights of lesbian, gay, bisexual and transgender (LGBT) people. It is involved in raising awareness of LGBT issues, advocating for better healthcare policies and sex education and providing LGBT with information, skills and...
Solid Education Development Organization (SEDO)
This is a national nongovernmental organization, nonprofit and services delivery organization mainly established to seek the welfare of children, youths and adulthood as well as community development projects that enhances the livelihood of people. It has a professional staff with qualified skills...


View Gallery of Glasgow Dining Sets (Showing 2 of 25 Photos)Popular Dining Room Furniture Glasgow Fascinating Dining Room Sets Dining Inside Glasgow Dining Sets | Find the Best Interior Design Ideas to Match Your Style.
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Home » Issues » 2014 » 160 » SteamOS
A first look at Valve's gamer Linux SteamOS
Valve has big plans for SteamOS, the new Linux that will run on the first generation of Steam machine gaming consoles.
Author(s): Tim Schürmann ,	Author(s): Joe Casad
Valve's Steam game platform has stirred up much discussion in the Linux gaming community since it was first ported to Linux two years ago. Like other popular game platforms, Valve is not just a developer tool, but also a distribution system, digital rights management framework, and communication tool designed to offer a complete, self-contained gaming universe.
According to Valve, the Steam platform now supports "over 2000 games from Action to Indie and everything in between." The community consists of more than six million online gamers.
Steam for Windows has been around since 2003, and Mac OS support first appeared in 2010. Linux came later, but since the arrival of the first Linux version in 2012, Valve has pushed swiftly into the Linux space. The reasons for this strong Linux emphasis became clear when Valve announced it was working on a hardware gaming console, which would be known as the Steam machine. What operating system would run on the Steam machine? Valve would need a system it could shape to its own needs – and develop free from the business agendas of closed-source OS vendors. They knew they would need to build their system on Linux.
Armed with the Steam machine as its very own video game console, Valve is set to do battle against the established console manufacturers [1]. Unlike Playstation, XBox, and Wii, the Steam machine is built entirely from commercially available PC components that anyone can bolt together. Valve simply stipulates the requirements and sells a special gamepad [2].
The Steam machine is still in beta testing, but Valve recently released the operating system that will run on it, a Debian-based Linux known as SteamOS. The SteamOS system is design primarily for gaming and running the Steam client software. (The Steam client provides access to the Valve Steam online store and has been available separately for Ubuntu for about a year [3].) SteamOS also comes with a complete Linux desktop that can easily launch and run any Linux program.
You can download SteamOS from Valve's Steampowered website [4]. We started up SteamOS for a first look at the future of Steam on Linux.
Debian instead of Ubuntu
The first pre-release version of SteamOS, published by Valve under the code name "Alchemist," is based on Debian 7.1 "Wheezy," which uses eglibc 2.17 from Debian "testing" and the 3.10 kernel with long-term support.
The SteamOS version we tested for this article only supported NVidia graphics card drivers; however, the Valve announced a new version on January 12 that includes support for AMD and Intel graphics cards.
Along with the graphics card drivers are a set of non-free firmware packages for a number of wireless chip sets by vendors such as Atheros and Realtek. Furthermore, Valve has developed its own compositor, a modified version of xcompmgr, which takes over when switching to full-screen mode in the Steam client.
The customized compositor is intended to guarantee a seamless transition between the Steam client, the games, and the SteamOS system [5].
It is not surprising that Valve is based on Debian, because the company had previously cooperated with Canonical and officially provided its Steam client for Ubuntu only. Valve is vague about the reasons for the change, saying only that relying on the Debian kernel is the best way to provide a fully independent "SteamOS experience" to their customers [5].
The system automatically launches the Steam client in full-screen mode (Figure 1). In this "Big Picture" mode, you control the Steam Machine with Valve's special controller. After terminating the Steam client, a Gnome desktop version 3.4 takes over; from the Gnome desktop, you can control the system as you would with any other Debian variant.
Figure 1: SteamOS starts the Steam client in full-screen mode.
Valve maintains the Steam client and Debian system via its own repository [6] and exclusively provides the packages installed by SteamOS. If you need any additional repositories, you must register them manually in /etc/apt/sources.list.
Steam Hammer
Valve provides two different installation methods for SteamOS [4]: In the Default Installation, the Clonezilla backup system restores the system, while the Custom Installation hands over to the Debian installer. In both cases, SteamOS deletes the whole of the first hard disk without asking and creates three partitions.
The first partition is occupied by the Debian system, and the second hosts a recovery copy of the installation media. Both partitions occupy 10GB each; the third takes up the remaining disk space, housing the home directories of the two standard users, desktop and steam; the third partition is also where the Steam client stores any games you purchase.
As the user account names suggest, the Linux desktop uses the desktop account, whereas steam is for the Steam client. The Steam client account has limited rights for security reasons.
If you want to try out SteamOS yourself, you'll need UEFI firmware, at least 4GB RAM, a supported graphics card (see the SteamOS website for the latest information on graphics card support), an empty hard drive with 500GB of storage space, and a 64 -bit CPU by Intel or AMD.
These specs reflect the requirements of the games and the Steam machine. In fact, SteamOS will run on any machine on which you can install Debian; only UEFI firmware is mandatory.
Thus, you can test SteamOS on a virtual machine with VirtualBox. You cannot launch any games, though, because VirtualBox does not support full 3D graphics. Make sure you have at least version 4.3.4 of VirtualBox; older versions can cause problems.
On the SteamOS download page [4], go to the Custom Installation section and Download the custom SteamOS beta installation, which is a 1GB zip file. Unzip the file in the steamos/ folder in your home directory, open a terminal and run the following command:
$ genisoimage -o steamos-1.0-uefi-amd64.iso -r -J ~/steamos/
You can use the package manager to install the genisoimage tool if necessary. Start VirtualBox and click New. Give the virtual machine a name. As the Type, select Linux; version is Debian 64 bit. Then, press Next to set the memory allocation to half of the physical RAM.
In the next step, you can Create a virtual disk and confirm the VDI and dynamically allocated settings. Set 500GB as the disk size, and then press Create. In the main window, press System on the right. Check Enable EFI activate (only special guests). Change to Display; then check Enable 3D acceleration and set the graphics memory to the maximum value.
Next, enable Storage, select empty, and click the CD icon in the Attributes section on the right. Then, choose Select file for virtual media and point to the file you created earlier, steamos-1.0-uefi-amd64.iso. For all other settings, you can simply keep the default values. Click OK and Start to launch the virtual PC. When the Steam logo appears, choose Automated Install.
Valve Announces SteamOS Beta
New Linux distro is optimzed for gaming.
Updates on Technologies, Trends, and Tools
Steam for Linux
Steam for Linux finally brings current games to the Linux desktop. Valve has put a lot of energy into the project, but the first steps on the new terrain still look a little shaky.
Valve bringing Steam to Linux?
Newly discovered Linux code keeps the dream alive.


This is a program where participants can only win by losing (weight, that is). The Plan is designed to ensure steady weight loss to all who follow this regimen. If you are following a gluten free regimen, you can continue to remain gluten free on this as well. In addition to clearing your body of toxins which impede liver functions, you will feel more alert and energetic.
This is a Diet Boot Camp for some and a Godsend for all. Part of what makes this a rigorous regimen is the absence of salt, sugar and butter. Flax oil and fax seeds are major staples and do help boost weight loss and fat reduction in the body. Although many may not find the flax oil and seeds palatable, the outcome is well worth the effort.
The recipes are nutritionally balanced with health properties listed throughout the book. That also makes this a distinctive book in re health and lifestyle changes. Followers of this program are treated to an array of delicious recipes and, as a bonus get to try many new things! Losing inches is part of what makes this program appealing and effective. Although it is not initially easy to follow, the payoff is worth it and staying with it gradually becomes easier.
If you are doing the Fat Flush Plan, this cook book is a must have. I bought the Fat Flush Plan, the journal and the cook book when I began Fat Flush. I can't tell you how often I refer to the cookbook for recipes! Some I cook just as is in the cookbook, others, I make slight substitutions to (as in the veggie of choice, an approved spice combination etc). This cookbook gives you a variety to choose from so that you don't get bored with food choices from menus listed in the Fat Flush Book.
1. The name. This is supposed to be a plan about cleansing the liver and following a healthy lifestyle. I tell no-one how I lost so much weight, because the name is embarassing and offensive.
2. You have to buy many books to understand the whole plan. I find this to be greedy on the part of the publisher. Just publish the plan, or even all the recipes in one place!
3. The cookbook has much filler material, very few recipes, and an absolutely useless index. I don't know about you, but the index is the most important part of a cookbook for me! This was horrible.
Lose weight, lower cholestrol & cleanse your Body!
Anyone on the Fat Flush diet plan needs this book.
The most frustrating cookbook ever written.
I was looking forward to using this book to get started on the Fat Flush Plan. Unfortunately, I now need to buy another book entitled "The Fat Flush Plan" to actually get the plan. My mistake. This book is supposed to be a cookbook filled with receipts that conform to the Fat Flush continuing program.
The problem is that, while the receipts may or may not be any good (see review from May 30, 2003), the book cannot be used for reference, as say, OTHER COOKBOOKS! Want to look up a recipe the sour cream substitute? You won't be able to find it in the index or table of contents. Want the author's recipe for yogurt dip? Good luck -- there are no listings for yogurt in the index AT ALL! How about a recipe involving nuts? You guessed it, NOTHING!


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The Oratorio della Beata Vergine delle Grazie (Oratory of the Blessed Virgin of the Graces), also known as the Oratorio della Madonna del Ponte is a Roman Catholic chapel-like building, or small church, located in the town of Fanano in the province of Modena, region of Emilia-Romagna, Italy. It is located near a bridge over the river Fellicarolo.

History
The oratory was erected in 1650 around an icon placed on an aedicule near the bridge. It was refurbished in the last century, and dedicated to those emigrating from the town. The plaque in front of the church recalls Felice Pedroni, one of the most prominent emigrants from Fanano. The main altar was constructed by the brothers Gherardini and houses a canvas depicting God the Father and Saints by Pellegrino da Fanano.

References

17th-century Roman Catholic church buildings in Italy
Churches in Fanano


Tuesday Night Group Meditation will be cancel on Dec-20-2016 and Dec-27-2016 while Meli is out of town.
Take a break from the challenges of a busy work week and re-energize your mind on the cushion with other practitioners.
Doors open at 6:00 pm. for extra sitting time, walking meditation, prostration practice or instruction if new.
Eight-movement Chan begins at 6:40 pm, finished up with a last sitting and Dharma sharing. All levels of practitioners are welcome.
Shoes are not allowed within the meditation center. For your comfort, we recommend wearing clean socks and loose clothing in layers for meditation.
This entry was posted in English Activities, Regular Activities. Bookmark the permalink.


A step-by -step book that helps teachers motivate diverse students become authors using Bookemon as the publisher. Each day provides the exact steps necessary to bring the student's work from an idea to a completed creation, published and ready to read.Common Core Standards included.
Both Dr. Ristovv-Reed and Dr. Haj-Broussard have published books addressing writing. In this case, they teamed up to create a book that is teacher friendly. With roots in education, the authors saw a need to create a manual with a day-to-day agenda of how to get even the most struggling students to create a part of the class book.


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Community > Classes & Events > Total Joint Replacement Pre-Operative Class February 27
This class requires orthopedic surgeon referral. Please call (220) 564-2527 to register or (220) 564-4774 for more information.
Total Joint Replacement Pre-Operative Class February 27
This two-hour pre-operative class is for total joint replacement patients only with a physician referral. If you are planning total hip or total knee replacement surgery, this class will help you prepare for your surgery and recovery.
This class should be scheduled with Licking Memorial Orthopedic Surgery. It is taught by a nurse, case manager and physical therapist – staff members who will be directly involved in your care. During the class, you will learn:
Actions to take before surgery
What you should know and ask about pre-admission testing
Information about the total knee or hip replacement procedure
What to expect during your Hospital stay
What types of resources are available to help you after discharge
Exercises to perform before and after surgery
How to prepare your home for a safe return
How to use a walker
How to protect your new hip or knee after surgery
What to expect during your recovery
The information discussed during the class also will be given to you in a packet for your review and planning. Classes are offered four times a month. We recommend that you bring a support person with you to class so that he or she will know how to best help you while you are recovering at home. You can register to attend a morning or late afternoon class.
1st Wednesday of the month from 4:00 p.m. to 6:00 p.m.
2nd Wednesday of the month from 9:00 a.m. to 11:00 a.m.
3rd Wednesday of the month from 9:00 a.m. to 11:00 a.m.
4th Wednesday of the month from 4:00 p.m. to 6:00 p.m.
Tamarack II Conference Room, 1945 Tamarack Road, Newark
2/27/2019, 4:00 PM - 6:00 PM
2 - Childbirth Education Class, February 2
4 - Infant CPR, February 4
6 - Prenatal Breastfeeding Basics Class, February 6
6 - Total Joint Replacement Pre-Operative Class February 6
7 - The Heart Truth: A Red Dress Event
7 - Newborn Basics, February 7
11 - Childbirth Education Class, February 11
13 - Breastfeeding Mothers Support Group, February 13
13 - Total Joint Replacement Pre-Operative Class February 13
16 - Prenatal Breastfeeding Basics Class, February 16
18 - Safe Sitter® Seminar, February 18
19 - Stork Tour, February 19
21 - Active•Senior Bingo
23 - February Walk with a Doc
23 - Infant CPR, February 23
23 - Newborn Basics, February 23
27 - Sibling Preparation Class, February 27
2 - Childbirth Education Class, March 2
4 - Infant CPR, March 4
6 - Prenatal Breastfeeding Basics Class, March 6
6 - Total Joint Replacement Pre-Operative Class March 6
9 - Active•Fit Junior Chef
9 - Newborn Basics, March 9


With little over a week we produced titles, programme graphics and set panels for Channel 5's live debate on crime and street violence.
"Alastair Stewart chairs a debate on the rising tide of violence in the UK, featuring a panel of politicians, policy makers, law enforcers, community leaders, journalists and former gang members. The programme will ask how widespread the problem is, what is causing it, whether Brexit-mania has taken politicians' eyes off the ball, who is to blame, and what can be done to turn the tide"


Dr Enrico Bonadio, a Senior Lecturer in the City Law School, comments on a landmark judgement which has further narrowed the gap between 'street art' and 'fine art'.
It's an extraordinary tale with a whiff of Banksy about it, although surprisingly, he was not involved. In a landmark ruling, 21 New York street artists have sued and won US$6.7m in damages from the owner of a building who destroyed their graffiti when he had the building demolished.
Following a three-week trial in November, on February 12, Judge Frederic Block ruled against Jerry Wolkoff, owner of the 5Pointz complex in Queens, conferring the biggest award of $1.3m on the building's mastermind-curator, graffiti artist Meres One, real name Jonathan Cohen.
The demolition of the former factory site turned graffiti mecca began in August 2014. The year before, artists had tried to oppose the warehouse's destruction, but an attempt to win an injunction to prevent the owner from knocking it down was unsuccessful.
In the 1990s, Wolkoff had agreed to allow the derelict factory to be used as a showcase for local graffiti talent. Called the Phun Factory, it was later renamed 5Pointz by Meres One in 2002. Under the artist's watchful eye, it evolved into an "aerosol art centre" and became famous the world over, a huge draw for graffiti aficionados and tourists alike.
In the end, Wolkoff profited from the graffiti and its destruction, when the value of the complex went up from $40m to $200m and permission to build luxury condos was obtained. Destroying 5Pointz, the judge stressed, permitted Wolkoff to realise that value.
Judge Block accepted that 45 artworks at the centre of the case had "recognised stature" and must receive protection under the Visual Artists Rights Act (VARA), a piece of legislation which was introduced in the US in 1990 to protect artists' moral rights – but has rarely been applied in their favour.
The rationale used by the court to confirm these artworks were of merit was crucial. To be considered such, works of art don't need to be mentioned in academic publications or be considered masterpieces, as the expert for the property owner had argued.
It was enough, the judge said, for the 5Pointz artists to show their professional achievements in terms of residences, teaching positions, fellowships, public and private commissions as well as media coverage and social media presence.
Judge Block also carefully examined Wolkoff's behaviour. The artworks – even those that could be easily removed as they had been placed on plywood panels – were whitewashed prior to demolition without giving artists the 90-day notice required by VARA. And the owner did so, the judge stressed, while conscious of the fact the artists were pursuing a VARA-based legal action. Such behaviour, the judge concluded, was not acceptable.
Such blatant disregard for an important legal provision pushed the judge to award the artists the maximum amount of damages allowable under the law. And although he did not grant the injunction requested by the artists in 2013, the judge had warned Wolkoff that he would be exposed to potentially high damages if the artworks were finally considered of "recognised stature", as they were by the February 12 ruling.
The court also took into account that 5Pointz had become an attraction for visitors to New York, with busloads of tourists, schoolchildren and even weddings heading to the site. Also thanks to Meres One's savvy stewardship for more than a decade, not only was the complex painted regularly by talented graffiti artists from all over the world, 5Pointz also attracted movie producers, advertising companies and bands, and was used as a location for the climax for the 2013 film Now You See Me.
The judge did not attach much importance to the fact that several artworks at 5Pointz were not meant to be permanent, an argument that had also been relied on by Wolkoff to claim that the pieces could not be protected. But the court reminded him that VARA protects both permanent and temporary art. This is an important provision of the law, especially when all that makes a work transient is the site owner's expressed intention to remove it.
This ruling may well embolden other graffiti artists to sue property owners who destroy artworks without following the correct procedure, even beyond the US. It may also make owners of buildings whose walls host graffiti more careful. Most important, the huge amount of damages awarded in this case will convince many that ignoring legal provisions and disregarding legitimate graffiti art is not a good idea. Judge Block made clear he awarded the maximum penalty allowable to deter other building owners from behaving in the same disrespectful way as Wolkoff.
Finally, the decision clearly marks the evolution of graffiti and street art, long considered to be temporary or transient artforms. It is now clear that artistic movements such as these aim to become more permanent forms of art, and that they have achieved a status similar to the one traditionally held by works of "fine art".


Enjoy beautiful westerly views of the Padres Ballpark, Coronado Bay Bridge, and San Diego Harbor from this spacious 1 bedroom/1 bath condo. Located in the Alta Building, Alta is the premier condominium complex in the Gaslamp District of Downtown San Diego. Alta contains the perfect balance of energy and tranquility. The Gaslamp district provides great nightlife and entertainment for adventure seekers while Alta presents a sense of calm with its peaceful corridors and friendly neighbors. Great Walkability.


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Tessa Rae releases a warm emo-alternative tune, entitled, "Heart Feels"
Alternative, Music
Tessa Rae is an Oakland-born singer-songwriter based in Los Angeles, California. Not too long ago, she released a warm emo-alternative tune, entitled, "Heart Feels".
Tessa Rae – "Heart Feels" single
"It's mushy-gushy. When we were writing it, there was something that felt really special about it. Most songs lose their spark after a while, but 'Heart Feels' feels very special to me. I always love listening to it." – Tessa Rae
'Heart Feels' contains a relatable storyline, ear-welcoming vocals, and enchanting instrumentation flavored with emo-alternative, dark pop, and urban hip-hop elements.
The likable tune will be featured on Tessa Rae's upcoming EP, set to be released later this year.
"I wanna make music that sounds timeless, which I'm realizing more as I get older." – Tessa Rae
Tessa Rae's music fits somewhere in the same ballpark with artists such as Lana Del Rey and Mazzy Star.
The rising songstress moved to L.A. when she was thirteen, a transitional period which introduced her to all that music had to offer.
Also, she grew up surrounded by fashion, thanks to her parents' Wasteland clothing stores in Los Angeles.
Her father had a crazy record collection and he introduced her to artists such as Joy Division and Sonic Youth. Later, she admitted, "I got into music through his taste."
We recommend adding Tessa Rae's "Heart Feels" single to your personal playlist. Also, let us know how you feel about it in the comment section below.
Tessa Rae
Tessa Rae releases a charming urban-pop tune, entitled, "Footsteps", featuring Brando


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Biochemistry (Moscow) (v.74, #4)
Carcinogenesis: Evolution of concepts by A. V. Lichtenstein (353-361).
Cancer is considered as an unintended consequence of internal imperfection of multicellular organisms: Darwinian evolution "does not foresee the future and does not plan for it", it is forced to handle only anything that it has at a given moment "at hand", which makes inevitable compromises and restrictions. In this case, there are a number of founding dogmas including mutagenesis as the main driving force of carcinogenesis; the environment as the main source of mutagenic effects; tumor monoclonality; cancer cell multistage transformation as Darwinian process of successive mutation—selection cycles. Recent discoveries complicate, supplement, and sometimes transform into an opposite fixed concepts. As a result, a new "image" of carcinogenesis is formed as a biological phenomenon whose conservation is indicative of its evolutionary utility.
Keywords: carcinogenesis; mutagenesis; epigenetics; transformation; differentiation
T-cadherin activates Rac1 and Cdc42 and changes endothelial permeability by E. V. Semina; K. A. Rubina; P. N. Rutkevich; T. A. Voyno-Yasenetskaya; Y. V. Parfyonova; V. A. Tkachuk (362-370).
In the present study, expression of T-cadherin was shown to induce intracellular signaling in NIH3T3 fibroblasts: it activated Rac1 and Cdc42 (p < 0.01) but not RhoA. T-Cadherin overexpression in human umbilical vein endothelial cells (HUVEC) using adenoviral constructs induced disassembly of microtubules and polymerization of actin stress fibers, whereas down-regulation of endogenous T-cadherin expression in HUVEC using lentiviral constructs resulted in micro-tubule polymerization and a decrease in the number of actin stress fibers. Moreover, suppression of the T-cadherin expression significantly decreased the endothelial monolayer permeability as compared to the control (p < 0.001).
Keywords: T-cadherin; Rho GTPases; endothelial cell permeability; microtubules; actin
Features of mitochondrial energetics in living unicellular eukaryote Tetrahymena pyriformis. A model for study of mammalian intracellular adaptation by E. A. Prikhodko; I. V. Brailovskaya; S. M. Korotkov; E. N. Mokhova (371-376).
Tetrahymena pyriformis is used in diverse studies as a non-mammalian alternative due to their resemblance in many main metabolic cycles. However, such basic features of mitochondrial energetics as ΔΨ (electrical potential difference across the inner mitochondrial membrane) or maximal stimulation of respiration by uncouplers with different mechanisms of uncoupling, such as DNP (2,4-dinitrophenol) and FCCP (p-trifluoromethoxycarbonylcyanide phenylhydrazone), have not been studied in living ciliates. Tetrahymena pyriformis GL cells during stationary growth phase after incubation under selected conditions were used in this study. Maximal stimulation of cellular respiration by FCCP was about six-fold, thus the proton motive force was high. The DNP uncoupling effect was significantly lower. This suggests low activity of the ATP/ADP-antiporter, which performs not only exchange of intramitochondrial ATP to extramitochondrial ADP, but also helps in the uncoupling process. It participates by a similar mechanism in electrophoretic transport from matrix to cytosol of ATP4− and DNP anion, but not FCCP anion. Thus, in contrast with mammalian mitochondria, T. pyriformis mitochondria cannot rapidly supply the cytosol with ATP; possibly the cells need high intramitochondrial ATP. The difference between DNP and FCCP is hypothetically explained by low ΔΨ value and/or an increase in concentration of long-chain acyl-CoAs, inhibitors of the ATP/ADP-antiporter. The first suggestion is confirmed by absence of mitochondria with bright fluorescence in T. pyriformis stained with the ΔΨ-sensitive probe MitoTracker Red. These data suggest that T. pyriformis cells are useful as a model for study of mitochondrial role in adaptation at the intracellular level.
Keywords: ATP/ADP-antiporter; membrane potential; mitochondria; Tetrahymena pyriformis ; uncouplers; DNP; intracellular adaptation
Correlation between hepatocarcinogenic effect of estragole and its influence on glucocorticoid induction of liver-specific enzymes and activities of FOXA and HNF4 transcription factors in mouse and rat liver by V. I. Kaledin; M. Yu. Pakharukova; E. N. Pivovarova; K. Yu. Kropachev; N. V. Baginskaya; E. D. Vasilieva; S. I. Ilnitskaya; E. V. Nikitenko; V. F. Kobzev; T. I. Merkulova (377-384).
It is known that the carcinogenic effect of estragole, a component of essential oils of many spicy plants, is characterized by species, tissue, and sex specificity. It causes mainly liver tumors in female mice but is not carcinogenic for male mice and for rats. In this work, the estragole hepatocarcinogenicity was shown for female mice of previously not studied ICR line. The strict correlation between estragole hepatocarcinogenicity and its ability to decrease the level of glucocorticoid induction of liver-specific enzymes tyrosine aminotransferase (TAT) and tryptophan oxygenase (TO) was found. Inhibition of TAT and TO inducibility by estragole takes place only in female mice but not in male mice and in rats. Studying the estragole effect on DNA-binding activity of transcription factors, present mainly in liver and regulating expression of genes encoding liver-specific proteins, has shown that estragole decreases FOXA and HNF4 activities but not activities of C/EBP and HNF1, and this happens only in female mice, for which this substance is hepatocarcinogen, but not in male mice and in rats. Pentachlorophenol, preventing hepatocarcinogenic effect of estragole, abolishes inhibitory influence of the latter on the TAT and TO glucocorticoid induction and restores DNA-binding activity of FOXA and HNF4. Thus, a correlation was revealed between the estragole hepatocarcinogenic effect and decrease in DNA-binding activity of transcription factors FOXA and HNF4, which might be indicative of the role of these factors in tumor suppression mechanisms in liver.
Keywords: hepatocarcinogens; estragole; tryptophan oxygenase; tyrosine aminotransferase; glucocorticoid induction; HNF4; FOXA
Effect of solvent phase transitions on enzymatic activity and structure of laccase from Coriolus hirsutus by E. V. Stepanova; T. V. Fedorova; O. N. Sorokina; V. V. Volkov; O. V. Koroleva; A. T. Dembo (385-392).
The effect of solvent phase transitions on catalytic activity and structure of the active site of laccase produced by the Basidiomycetes Coriolus hirsutus 072 was studied. As shown by small-angle X-ray scattering, laccase exists in solution as a mixture of monomeric and aggregated particles in the percent ratio 85: 15. This ratio did not change on phase transitions. A complex nature of laccase activity dynamics during thawing and further heating to 20°C was shown. Spontaneous oxidation of T1 copper center in the temperature range 12–20°C was not observed. According to spectral data, the structure of laccase active sites including all copper centers of types T1, T2, and T3 changes during the phase transition.
Keywords: laccase; phase transitions; small angle X-ray scattering (SAXS); EPR spectra; active site
Monitoring protein folding and unfolding pathways through surface hydrophobicity changes using fluorescence and circular dichroism spectroscopy by J. Lamba; S. Paul; V. Hasija; R. Aggarwal; T. K. Chaudhuri (393-398).
In the present study we have investigated the characteristics of folding and unfolding pathways of two model proteins, ovalbumin and α-lactalbumin, monitored through the changes in surface hydrophobicity using fluorescence and circular dichroism spectroscopy. In the unfolding process, it was observed that ovalbumin and α-lactalbumin followed a three state transition pathway involving an intermediate state having high surface hydrophobicity. The intermediate state has also been characterized by circular dichroism spectroscopy, and it was found that the intermediate retained almost the same secondary structure as the native proteins, and therefore it can be referred to as molten globule state. The refolding process was monitored using fluorescence and circular dichroism spectroscopy, and it was observed that the refolding of α-lactalbumin was reversible and proceeded through the accumulation of similar type of intermediates as observed during its unfolding pathway. However, on refolding from the guanidine hydrochloride-denatured state, ovalbumin reached a different folded state.
Keywords: surface hydrophobicity; protein unfolding; folding intermediate; fluorescence and circular dichroism spectroscopy; extrinsic fluorescence spectroscopy
Design of a novel interleukin-13 antagonist from analysis of informational structure by A. N. Nekrasov; L. E. Petrovskaya; V. A. Toporova; E. A. Kryukova; A. V. Rodina; E. Yu. Moskaleva; M. P. Kirpichnikov (399-405).
Interleukin-13 (IL-13) is one of the cytokines involved in the development of Th2-type immune response. It plays an important role in the pathogenesis of asthma and other allergic diseases. Two deletion forms of IL-13 were constructed on a basis of informational structure analysis and expressed in E. coli cells. They were found to differ in ability to stimulate proliferation of TF-1 cell line. Deletion variant 146 (DV146) completely lacks such activity, whereas DV148 provides about 50% of the proliferation stimulation. The simultaneous addition of DV146 with full-length IL-13 suppresses proliferation depending on the concentration of the deletion form. Thus, the designed protein acts as an antagonist of IL-13.
Keywords: ANIS method; informational structure; deletion variant; IL-13 antagonist; TF-1 proliferation
Chaperone Skp from Yersinia pseudotuberculosis exhibits immunoglobulin G binding ability by E. V. Sidorin; R. H. Ziganshin; G. A. Naberezhnykh; G. N. Likhatskaya; E. V. Trifonov; S. D. Anastiuk; O. V. Chernikov; T. F. Solov'eva (406-415).
A low-molecular-weight cationic protein that can bind human and rabbit immunoglobulins G has been isolated from Yersinia pseudotuberculosis cells. This immunoglobulin binding protein (IBP) interacts with IgG Fc-fragment, the association constant of the resulting complex being 3.1 μM−1. MALDI-TOF mass spectrometry analysis of IBP revealed its molecular mass of 16.1 kDa, and capillary isoelectrofocusing analysis showed pI value of 9.2. N-Terminal sequence determination by Edman degradation revealed the sequence of the 15 terminal amino acid residues (ADKIAIVNVSSIFQ). Tryptic hydrolysate of IBP was subjected to MALDI-TOF mass spectrometry for proteolytic peptide profiling. Based on the peptide fingerprint, molecular mass, pI, and N-terminal sequence and using bioinformatic resources, IBP was identified as Y. pseudotuberculosis periplasmic chaperone Skp. Using the method of comparative modeling a spatial model of Skp has been built. This model was then used for modeling of Skp complexes with human IgG1 Fc-fragment by means of molecular docking.
Keywords: chaperone Skp; immunoglobulin-binding protein; immunoglobulin G; Fc fragment of IgG; computer modeling
Structure of O-antigen and functional characterization of O-antigen gene cluster of Salmonella enterica O47 containing ribitol phosphate and 2-acetimidoylamino-2,6-dideoxy-L-galactose by A. V. Perepelov; B. Liu; S. N. Senchenkova; A. S. Shashkov; L. Feng; L. Wang; Y. A. Knirel (416-420).
An O-polysaccharide was isolated by mild acid degradation of the lipopolysaccharide of Salmonella enterica O47 and studied by sugar analysis along with one- and two-dimensional 1H- and 13C-NMR spectroscopy. The following structure of the linear ribitol phosphate-containing repeating unit of the O-polysaccharide was established: $$ o 2) - D - Ribitol - 5 - P - (O o 6) - alpha - D - Galp - (1 o 3) - alpha - L - FucpNAm - (1 o 3) - eta - D - GlcpNAc - (1 o , $$ where FucNAm stands for 2-acetimidoylamino-2,6-dideoxy-L-galactose. About 10% of Gal is O-acetylated at position 4 and another minor O-acetyl group is present at an undetermined position. Functions of the S. enterica O47 antigen biosynthetic genes were tentatively assigned by comparison with gene databases and found to be in agreement with the O-polysaccharide structure. A comparison of the O-antigen gene clusters of S. enterica O47 and E. coli O145 suggested their close evolutionary relationship.
Keywords: Salmonella enterica ; lipopolysaccharide; bacterial polysaccharide structure; acetimidoyl group; ribitol phosphate; O-antigen gene cluster
Effect of peripheral benzodiazepine receptor (PBR/TSPO) ligands on opening of Ca2+-induced pore and phosphorylation of 3.5-kDa polypeptide in rat brain mitochondria by O. V. Krestinina; D. E. Grachev; I. V. Odinokova; G. Reiser; Yu. V. Evtodienko; T. S. Azarashvili (421-429).
The effect of nanomolar concentrations of PBR/TSPO ligands—Ro 5-4864, PK11195, and PPIX—on Ca2+-induced permeability transition pore (PTP) opening in isolated rat brain mitochondria was investigated. PBR/TSPO agonist Ro 5-4864 (100 nM) and endogenous ligand PPIX (1 μM) were shown to stimulate PTP opening, while antagonist PK11195 (100 nM) suppressed this process. Correlation between PBR ligand action on PTP opening and phosphorylation of a 3.5 kDa polypeptide was investigated. In intact brain mitochondria, incorporation of [γ-32P]ATP into 3.5 kDa peptide was decreased in the presence of Ro 5-4864 and PPIX and increased in the presence of PK11195. At threshold Ca2+ concentrations leading to PTP opening, PBR/TSPO ligands were found to stimulate dephosphorylation of the 3.5 kDa peptide. Specific anti-PBR/TSPO antibody prevented both PTP opening and dephosphorylation of the 3.5-kDa peptide. The peptide was identified as subunit c of FoF1-ATPase by Western blot using specific anti-subunit c antibody. The results suggest that subunit c of FoF1-ATPase could be an additional target for PBR/TSPO ligands action, is subjected to Ca2+- and TSPO-dependent phosphorylation/dephosphorylation, and is involved in PTP operation in mitochondria.
Keywords: brain mitochondria; peripheral benzodiazepine receptor; permeability transition pore; FoF1-ATPase subunit c ; PBR/TSPO
Analysis of mitochondrial DNA somatic mutations in OXYS and Wistar strain rats by U. N. Rotskaya; I. B. Rogozin; E. A. Vasyunina; N. G. Kolosova; B. A. Malyarchuk; G. A. Nevinsky; O. I. Sinitsyna (430-437).
Rats of the OXYS strain are sensitive to oxidative stress and serve as a biological model of premature aging. We have compared spectra of somatic mutations in a control region of mtDNA from the liver of the OXYS rat strain and of Wistar rats as a control. The majority of nucleotide substitutions in the mutation spectra were represented by transitions: 94 and 97% in the OXYS and Wistar rats, respectively. It was shown that 40% of somatic mutations in the control region of mtDNA from Wistar rats were significantly consistent with the model of dislocation mutagenesis. No statistical support for this model was found for mutations in the control region of mtDNA from OXYS rats. The mutation frequency in the ETAS section was higher in the OXYS strain rats than in Wistar rats. These results suggest different mechanisms of mutagenesis in the two rat strains under study.
Keywords: OXYS rats; Wistar rats; somatic mutations; mtDNA; liver
Electrochemistry of cytochromes P450: Analysis of current-voltage characteristics of electrodes with immobilized cytochromes P450 for the screening of substrates and inhibitors by V. V. Shumyantseva; T. V. Bulko; G. P. Kuznetsova; N. F. Samenkova; A. I. Archakov (438-444).
In the current study, an approach to elucidating the substrate specificity of cytochromes P450 based on the analysis of current-voltage characteristics of voltammograms and amperograms is proposed. Data on the electrochemical behavior of bioelectrodes with immobilized cytochromes P450 2B4, 1A2, 3A4, 11A1 (P450scc), and 51b1 (Mycobacterium tuberculosis sterol 14α-demethylase or CYP51 MT) in the presence of typical substrates and inhibitors for these hemoprotein forms are reported. Immobilization of the enzymes was accomplished by using graphite screen-printed electrodes modified with gold nanoparticles and with the synthetic membrane-like compound didodecyldimethylammonium bromide. The method of electro-analysis can be applied to the search of potential substrates and inhibitors of cytochromes P450 and to creation of multichannel electrochemical plates (chips, panels) with immobilized cytochromes P450.
Keywords: cytochrome P450; colloidal gold nanoparticles; bioelectrochemistry; drug metabolism
Inactivation of genes encoding superoxide dismutase modifies yeast response to S-nitrosoglutathione-induced stress by O. V. Lushchak; N. Z. Nykorak; T. Ohdate; Y. Inoue; V. I. Lushchak (445-451).
Antioxidant enzymes can modify cell response to nitrosative stress induced, for example, by nitric oxide or compounds decomposing with its formation. Therefore, we investigated the effects of S-nitrosoglutathione (GSNO) on cell survival, activity of antioxidant enzymes, and concentrations of reduced and oxidized glutathione in parental and isogenic strains defective in Cu,Zn- or Mn-superoxide dismutases (Cu,Zn-SOD and Mn-SOD, respectively), or in both of them. Stress was induced by incubation of the yeast with 1–20 mM GSNO. The strains used demonstrated different sensitivity to GSNO. A Cu,Zn-SOD-defective strain survived the stress better than the parental strain, while the double mutant was the most sensitive to GSNO. The ·NO-donor at low concentrations (1–5 mM) increased SOD activity, but its high concentrations (10 and 20 mM) decreased it. The activity of catalase in all strains was enhanced by GSNO. Inhibition of protein synthesis by cycloheximide did not prevent the activation of SOD, but it prevented the activation of catalase. These facts suggest that SOD was activated at a posttranslational level and catalase activity was enhanced via de novo synthesis. A GSNO-induced increase in oxidized glutathione level in the studied yeast strains might account for cell killing by GSNO due to the development of oxidative/nitrosative stress.
Keywords: yeast; superoxide dismutase; S-nitrosoglutathione; nitric oxide; markers of oxidative stress
Properties of mutant reaction centers of Rhodobacter sphaeroides with substitutions of histidine L153, the axial Mg2+ ligand of bacteriochlorophyll BA by M. M. Leonova; L. G. Vasilieva; R. A. Khatypov; V. A. Boichenko; V. A. Shuvalov (452-460).
Mutant reaction centers (RC) from Rhodobacter sphaeroides have been studied in which histidine L153, the axial ligand of the central Mg atom of bacteriochlorophyll BA molecule, was substituted by cysteine, methionine, tyrosine, or leucine. None of the mutations resulted in conversion of the bacteriochlorophyll BA to a bacteriopheophytin molecule. Isolated H(L153)C and H(L153)M RCs demonstrated spectral properties similar to those of the wild-type RC, indicating the ability of cysteine and methionine to serve as stable axial ligands of the Mg atom of bacteriochlorophyll BA. Because of instability of mutant H(L153)L and H(L153)Y RCs, their properties were studied without isolation of these complexes from the photosynthetic membranes. The most prominent effect of the mutations was observed with substitution of histidine by tyrosine. According to the spectral data and the results of pigment analysis, the BA molecule is missing in the H(L153)Y RC. Nevertheless, being associated with the photosynthetic membrane, this RC can accomplish photochemical charge separation with quantum yield of approximately 7% of that characteristic of the wild-type RC. Possible pathways of the primary electron transport in the H(L153)Y RC in absence of photochemically active chromophore are discussed.
Keywords: bacterial photosynthesis; reaction center; photochemical charge separation; site-directed mutagenesis; bacteriochlorophyll; Rhodobacter sphaeroides
Superoxide formation as a result of interaction of L-lysine with dicarbonyl compounds and its possible mechanism by K. B. Shumaev; S. A. Gubkina; E. M. Kumskova; G. S. Shepelkova; E. K. Ruuge; V. Z. Lankin (461-466).
The EPR signal recorded in reaction medium containing L-lysine and methylglyoxal is supposed to come from the anion radical (semidione) of methylglyoxal and cation radical of methylglyoxal dialkylimine. These free radical inter-mediates might be formed as a result of electron transfer from dialkylimine to methylglyoxal. The EPR signal was observed in a nitrogen atmosphere, whereas only trace amounts of free radicals were registered under aerobic conditions. It has been established that the decay of methylglyoxal anion radical on aeration of the medium is inhibited by superoxide dismutase. Using the methods of EPR spectroscopy and lucigenin-dependent chemiluminescence, it has been shown that nonenzymatic generation of free radicals including superoxide anion radical takes place during the interaction of L-lysine with methylglyoxal — an intermediate of carbonyl stress — at different (including physiological) pH values. In the course of analogous reaction of L-lysine with malondialdehyde (the secondary product of the free radical derived oxidation of lipids), the formation of organic free radicals or superoxide radical was not observed.
Keywords: free radicals; malondialdehyde; methylglyoxal; modification of amino acids
Programmed cell death in cancer progression and therapy, in advances in experimental medicine and biology, Vol. 615 by A. A. Philchenkov (467-468).


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NewsLocal NewsSan Diego News
Strip club hands out branded tents to homeless
Posted: 11:35 PM, Jan 06, 2020
By: Anthony Pura
SAN DIEGO (KGTV) - A local strip club give out nearly 150 tents to the homeless in San Diego. The tents are branded with "Deja Vu Showgirls."
Déjà vu describes itself as the "#1 erotic entertainment chain in the world" on its website. The website also says it operates four business locations in San Diego, including 'Déjà vu Showgirls' on Midway Drive.
A company spokesperson says the 150 tents given out in San Diego this December is part of the company's outreach program. They say they've done this type of outreach every year for the past five years in five cities with large homeless concentrations, including Los Angeles and Las Vegas.
In addition, they also passed out close to 3,000 bottles of water to the homeless in San Diego.
A picture of one of the tents was posted onto the "Homeless News San Diego" Facebook page and it received both praise and criticism. Some believed it was a form of shameless advertising. Others applauded the company for stepping up to help.
A Deja Vu spokesman sent 10News the following statement:
"Deja Vu highly prides itself on community service, nationally spending in excess of $100,000 annually on worthy causes. Our homeless tent program is one of many initiatives, and while we understand that some people do not agree with our business, however lawful, we feel that the program is simply us doing our part to to assist the homeless community under a state government that has otherwise completely failed on this important issue. If every business retained this attitude, homelessness likely wouldn't be a problem at all."