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HMAS Albatross welcomes Navy's latest graduate Aviators
Published on August 06, 2018 by LEUT Anthony Martin (author), POIS Justin Brown (photographer)
Commanding Officer 723 Squadron, Commander Bruce Willington, RAN, left, with graduates of Aircrewman Rotary Course 15, Leading Seaman Daniel Atkins, Able Seaman Brendan Raychaudhuri and Able Seaman Corey Mumberson, at HMAS Albatross.
Deputy Commander Fleet Air Arm, Captain Peter Ashworth presented Aircrewman wings to Leading Seaman (LS) Daniel Atkins, Able Seaman (AB) Corey Mumberson and AB Brendan Raychaudhuri on Friday 27 July 2018.
One final salute for an old sailor
Published on August 04, 2018 by CMDR Andrew Burnett (author), Unknown (photographer)
Jeff McIntyre, RAN (left) points out the bullet hole in his helmet to a US Army colleague in Tan An, South Vietnam in 1968.
CO NHQ-SA, CMDR Andrew Burnett attended Rose Court Residential Aged Care Home in Adelaide recently to present the Unit Citation for Gallantry (UCG) to Jeffrey McIntyre, a former member of the RAN Helicopter Flight Vietnam (RANHFV).
Remembering Tony Bullimore
Published on August 01, 2018 by LEUT Des Paroz (author), Kerry Berrington (News Limited) (photographer)
Solo round-the-world sailor Tony Bullimore (right) embraces Chief Petty Officer Peter Wicker, one of his rescuers from HMAS Adelaide (II) in January 1997.
The Royal Australian Navy has paid tribute to solo sailor Tony Bullimore, who has passed away aged 79.
Honouring 40 years of loyal service
Published on August 02, 2018 by Mr Andrew Bujdegan (author), LSIS Richard Cordell (photographer)
Chief of Navy, Vice Admiral Michael Noonan, AO, RAN (left), presents Lieutenant Commander Guy Burton (centre) with his Federation Star for 40 years of naval service, with Chris Burton (right), during HMAS Stirling's 40th anniversary celebrations held at the Sir James Stirling Mess, Garden Island, Western Australia.
Receiving the highly coveted Federation Star is a milestone in anyone's career, and on Friday 29 July, Lieutenant Commander Guy Burton, RAN was presented with his Federation Star by Chief of Navy Vice Admiral Michael Noonan, AO, RAN at HMAS Stirling, the home of the Submarine Force in Rockingham, Western Australia.
Chief of Navy leads the way in 2018 Defence Blood Challenge
Published on August 30, 2018 by LEUT Dave Devlin (author), SGT Max Bree (photographer)
Chief of Navy, Vice Admiral Michael Noonan, AO, RAN, has his plasma taken by nurse Annita Howard, at the Civic Plasma Donor Centre in Canberra, during an event to mark the start of the 2018 Defence Blood Challenge.
The 2018 Defence Blood Challenge has been officially launched at the Civic Plasma Donor Centre in Canberra.
HMAS Adelaide supports Sydney's homeless
Published on August 29, 2018 by Maj Kaho Lai (author), ABIS Kieran Dempsey (photographer)
Leading Seaman Boatswain's Mate Zachary Kelly with Able Seaman Maritime Logistics - Supply Chain Ayla-Crystal Peacock prior to shaving off LS Kelly's beard for HMAS Adelaide's chosen charity organisation - Matthew Talbot Hostel.
Distance is no barrier to a good deed for Sydney's homeless. Halfway across the Pacific, the crew of HMAS Adelaide did good for the Sydney based Matthew Talbot Hostel, the ship's charity of choice.
A great Navy day for Tennant Creek students
Published on August 25, 2018 by SBLT Max Logan (author), POIS James Whittle (photographer)
Students and teachers from Tennant Creek High School on the forecastle of HMAS Launceston with Commanding Officer, Lieutenant Commander James Brewster (right), and Midshipman Harry Nixon (rear left), during their visit to HMAS Coonawarra in Darwin.
Navy has continued to strengthen ties with the Northern Territory community during a school visit to the Top End Navy establishment, HMAS Coonawarra.
Navy musician lands trip to the centre
Published on August 24, 2018 by LCDR Ainsley Slattery (author), CAPT Michel de Jonge (photographer), PTE Susan Touch (photographer)
Members of the Australian Army Band Australia and AB MUSN Labozzetta in Yalata, South Australia.
A Royal Australian Navy musician has ventured in the opposite direction to the ocean to represent Navy in rural Australia.
Leadership challenge on STS Young Endeavour
Published on August 26, 2018 by Ms Natalie Staples (author), Young Endeavour Youth Scheme (photographer)
Winta Eyob and Mohammad Semra onboard STS Young Endeavour with the youth crew embarked on voyage 12/18 from Brisbane to Mackay.
Two members of west Melbourne's African-Australian community recently sailed on Royal Australian Navy operated tall-ship STS Young Endeavour as part of a leadership challenge.
Darwin based Navy members head to the Red Centre for Vietnam Veterans Day
Published on August 22, 2018 by LEUT Tony White (author), Department of Defence (photographer)
Navy members at the Alice Springs Vietnam Veterans Day service in Alice Springs, led by Lieutenant Commander Kate Woodall, right.
Navy members based at HMAS Coonawarra in Darwin travelled to Alice Springs to show their respects at the Vietnam Veterans Day memorial service last Saturday. They were joined by members from the RAN Band Sydney and Navy Headquarters South Australia as part of Navy's Community Engagement Program.


Meet Omar (son) and Peter (father) Hamilton, a running duo that we often see at local events. We asked Peter what's next for these two.
TS: You and Omar have been Fanatics in the past – what's your running schedule look like this year?
Peter: I'm considering becoming a Fanatic again. However, I have plantar fasciitis in my left foot; which has put a temporary halt to my running. I fully intend to continue running and becoming a Fanatic again, once I get rid of the plantar fasciitis!
TS: What motivated you to sign up for Fanatic in the past?
Peter: I have always loved running races with Omar. He and I have collected a lot of Track Shack shirts and medals over the years. Omar takes great pride in his running. He keeps all his bib numbers as well.
Peter: Omar and I have been Track Shack Fanatics and we've ran the OUC Orlando Half Marathon, as well. Since Omar graduated from high school this year, and will be going away, he and I will most likely not be running races much in the future. However, my youngest son Malachi and I will be picking up where Omar and I left off. Activities with my sons are very enjoyable and running with them helps us have some great quality time.
TS: Can you think of a favorite memory or race you ran together and why it was special?
Peter: My favorite Track Shack run was the OUC half marathon. We both somewhat trained for it. Omar had never run that far before and finished well despite the distance and initial concerns he had. I had leg cramps for the last 3 miles, and was very happy to see him at the finish line smiling at me. There is no doubt that our runs have helped bring us closer and provided outstanding memories for both of us.
TS: Do you have goals for the next running season?
Peter: Omar and I plan to run in the Watermelon 5k. After that I will resume running on my own until Malachi is a little older. We like how running pushes us to get out of our comfort zones. God willing I have the opportunity to do a few 5k's and a half marathon this year.
Good luck to Omar as he begins the next chapter of his life. It will be even more special the next time we see Omar and Peter lining up at a start of a race. Happy Father's Day Peter – thanks for sharing your story and your love of running with your boys!


Whey Protein Powder is considered as a complete protein diet as it contains all the 9 essential amino acids. It is a mixture of beta- lactoglobulin, alpha lactalbumin, immunoglobins and bovine serum albumin. It provides benefits which includes weight loss and lower your cholesterol and boosts muscle strength prior to following your workouts.
There are three primary types of whey protein: whey protein concentrate (WPC), whey protein isolate (WPI) and whey protein hydrolysate (WPH).
Whey protein concentrate: WPC contains low levels of carbohydrates and fat, the percentage of protein vary from 30 to 90 percent.
Whey protein isolate: WPI contains around 90 percent of protein which is much higher than WPC and thus have no fat or lactose.
Whey protein hydrolysate: WPH absorbs faster than the WPC and WPI and considered as pre-digested protein for the body to absorb protein.
Mixability: It refers to the protein powder which can dissolves quickly and makes a more enjoyable drinking experience.
Container Size: Its generally more cost effective if you buy it in bulk as the more grams or ounces of quantity you take the more benefit you get from it.
Now it's the time to present you the top 10 whey protein powders that provides you the best results in building your muscle strength and weight loss prior to following your Workouts. These are also available on Amazon!
Natural force organic whey protein has a Net weight of 402 grams or 14.1 oz which is a clean alternative to conventional way that has no artificial ingredients and is sourced from grass fed, free range heritage breed jersey cows. This protein powder is gluten-free, soy free and flavoured with organic ingredients and sweetened with organic whole stevia leaf. It is a delicious and nutritious for your daily smoothie or shakes.
It is best tasting grass-fed whey protein powder with flavours like Cacao Bean, Vanilla bean and Coffee bean and it is a delicious way to add clean protein to shakes, smoothies or baked goods. It is USDA Organic grass Fed whey protein powder which is sourced exclusively from family owned farms in northern California. It provides benefits which includes weight loss and lower your cholesterol and boosts muscle strength prior to following your workouts.
30-day money back guarantee if you don't feel an incredible difference and are completely Satisfied, request for the refund of your money.
This whey protein has a Net weight of 13.76 oz or 400 grams with no flavors, sweeteners, fillers, or additives of any kind. This Unflavored organic whey protein adds clean protein to shakes, smoothies or baked goods without affecting their flavor. It is a clean alternative to conventional whey that has no artificial ingredients and is sourced from grass-fed, free range heritage-breed jersey cows.
It is the best Unflavored grass-fed whey protein powder with no sweeteners and fillers of any kind, so you can add it to your daily protein diet to Shakes, smoothies or baked goods without affecting their flavor. For the 20 grams of undenatured whey protein per scoop you will get 42% of your daily RDA for protein in each one scoop serving.
Excessive use of whey protein powder is bad for the kidneys but may vary from individual to another individual's health.
It is pure organic whey from the milk of grass-fed cows, with Soy free Gluten free, processed without acid or bleach, non-denatured from family farms in Northern California. It has no added sugar, sweetener, preservatives, colors or flavors.
It is 100 % pure grass-fed whey protein from the milk of jersey cows that graze freely on lush green pastures. Raw grass-fed whey is minimally processed at low temperature and is higher in antioxidants and other nutrients than conventional whey powders. It tastes so amazing by itself, and there is no need to add any sweeteners, flavors or fillers.
It is highest quality, cold processed, Soy free, Hormone free, Gluten free, and contains only one ingredient with 100% pure grass fed whey protein from the milk rich in omega -3s of the jersey cows that graze freely on lush green pastures. It contains no added preservatives, sweeteners or fillers and processed without acid or bleach.
It is 100 % all-natural grass fed and undenatured Promix Standard whey protein powder. It has 10 Chocolate samples and comes with five flavors like peanut butter, chocolate peanut, vanilla, chocolate and Unflavored which can be used in 10 servings.
Some of the complications associated with the whey protein includes gas, bloating, headaches, cramps and fatigue.
Body Logix Natural Whey helps you supplement your diet with much-needed protein. The whey is sourced from grass-fed cows and the powder contains no artificial colors, flavors or sweeteners. These products are manufactured in an NSF-GMP certified facility located in Canada. You can add the powder to your breakfast cereal for a boost in the morning; it will help you feel fuller for longer. Blend the powder into water, soy milk, almond milk, or cow's milk after a workout.
It will help you feel fuller for longer and recover your muscles faster by taking it with milk or water after your workout. You can also add it to the oatmeal bars and pancakes to make a meal more balanced diet. It contains no Artificial colors, Flavors and sweeteners.
It comes in 3 sizes 1.6 lb, 2 lb, and 4 lb with five amazing flavors like Vanilla bean, Caramel chocolate chip, decadent chocolate, snickerdoodle, and Unflavored.
This whey protein is sourced from the premium US Dairy Farms from the high-quality grass-fed cows that tastes amazing. It comes in 2 sizes 5 lb and 2 lb with three flavors Chocolate, vanilla and Unflavored. The Unflavored grass fed whey powder contains zero additives, no added sugar, sweeteners, colors, preservatives and is hormone free, Gluten free and soy free.
This Whey Protein is Packed Full of Amino Acids. Each Serving contains 24 grams of Protein, 2.5 grams of Fat, 1 gram of Carb and Only 122 Calories. It mixes easily with any beverages and the perfect Unflavored protein for smoothies, drinks or even baking. If you are not satisfied with this product, they offer you 100% Money back guarantee.
Make your own Custom Smoothies with this Unflavored Whey Protein! It's Unflavored so you can Mix with Anything!
This Whey Protein is Packed Full of Amino Acids. Each Serving contains 24 grams of Protein, 2.5 grams of Fat, 1 gram of Carb and Only 122 Calories.
Naked Whey is pure protein and not dressed up with additives like artificial flavors or sweeteners like most brands. It contains the essential amino acids, glutathione, and clean protein. It comes with maximum nutrition of 25 grams of protein, 2 grams of sugar, 3 grams of Carbs and 5.9 grams of branched chain amino acids per serving. It comes with 5 flavors like Chocolate, vanilla, matcha, strawberry, and Unflavored with 2 sizes of around 5 LB and 1 LB.
It is 100% Grass-fed Pure whey protein with zero additives and has no artificial sweeteners, flavors, or colors and is GMO free, hormone free, Soy free and Gluten free. Unlike most whey protein powders, Naked Whey is cold processed to ensure zero contamination from chemical detergents (no acid or bleach), synthetic additives, or heavy metals, and this maintains important naturally occurring growth factors.
It is your best workout partner as you can add a banana, blueberries and more to create your pre and post workout whey shakes, smoothies and recipes to take your muscle gains and recovery to new heights.
This whey protein powder has 24 grams protein, 5.4 grams of BCAAs (branched chain amino acids) and no added sugar. It is 100% grass-fed whey protein which comes from pasture-raised dairy cows that eat a nutrient-rich diverse diet of grasses which creates a higher concentration of vitamins and minerals. This Chocolate Mocha Whey is made with delicious 100% cold-pressed cacao and pure decaffeinated coffee powder then lightly sweetened with monk fruit extract.
Levels Whey Protein goes through rigorous testing to meet the highest quality standards. Our paleo and keto friendly whey is gluten free, soy free, antibiotic free, rGBH/rBST hormone free, and contains no artificial flavors, no so-called "natural flavors", no artificial sweeteners and no GMOs. It comes in 4 flavors like chocolate mocha, vanilla bean, vanilla cinnamon, and Unflavored and the sizes comes in 2 LB and 5 LB.
This whey is gluten free, soy free, antibiotic free, rGBH/rBST hormone free, and contains no artificial flavors, no so-called "natural flavors", no artificial sweeteners and no GMOs.
This Chocolate Mocha Whey has 24g Protein, 5.4g BCAAs (branched-chain amino acids), and no added sugars.
This Whey is made with delicious 100% cold-pressed cacao and pure decaffeinated coffee powder then lightly sweetened with monk fruit extract.
This whey is never bleached and contains no fillers. Each batch is blended with less than 1% non-gmo sunflower lecithin for added nutrition and so your protein will mix instantly.
This whey is a gold standard uses pure Whey Protein Isolates as the primary ingredient. Combined with ultra-filtered whey protein concentrate, each serving provides 24 grams of all-whey protein and 5.5 grams of naturally occurring Branched Chain Amino Acids (BCAAs) which are prized by athletes for their muscle building qualities. It comes in 17 flavors like Double rich chocolate, strawberry, milk chocolate, French vanilla creme, mocha cappuccino, white chocolate etc. It comes in 4 sizes of 5-pound, 3.3-pound, 1 pound, and 10 pounds.
This is Gold Standard 100% whey protein powder that contains 24 grams of protein, 5.5 grams of naturally occurring BCCAs and 4 grams of naturally occurring glutamine per serving. This whey can be consumed as shakes and smoothies before or after exercise which helps to kickstart the muscle recovery for men and women.
This article was meant to give you a thorough review of the top 10 Whey Protein Powder in the market. Keep in mind that taking too much protein is useless as your body can only utilize a limited amount of protein at a time. However, moderate consumption of whey protein supplements is well tolerated by most people. Whey protein is not just a convenient way to boost your protein intake, it may have some powerful health benefits as well. So, go ahead and invest in your choice of Whey Protein Powder and Stay Healthy!


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Tudor Timelines
— Main Menu —Homepage Tudor Timelines Book Reviews Portraits About Me
Henry's Mother Remarries – January 3, 1458
Michele Morrical
Margaret Beaufort married 3rd husband Sir Henry Stafford after her mourning period for Edmund was complete. Margaret and her new husband lived at Bourne Castle in Lincolnshire while her son Henry Tudor stayed at Pembroke Castle with his uncle Jasper Tudor. Margaret's first marriage contract was made when she was only 5 years old. She was to marry her ward's son, John de la Pole, but the contract was declared null and void soon thereafter by papal dispensation on the basis that they were too closely related.
Blogger, medieval historian, and soon-to-be published author. My first book entitled "Usurper: A New Look at Six Medieval Kings" will be released in the Fall of 2021 by Pen & Sword Books.
Book Review: King Stephen and the Anarchy by Chris Peers
Book Review: Matilda-Empress, Queen, Warrior by Catherine Hanley
Tudor Weekly Roundup: June 1-7, 2019
Tudor Weekly Roundup: May 25-May 31, 2019
Empress Matilda
Stephen I
The Beauforts
Tudor Weekly RoundUp
I've been doing a lot of research on Empress Matilda and her cousin King Stephen for my upcoming book on medieval u… https://t.co/WlzXG6udBY
Copyright © 2019 - Michele Morrical

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: JSOUP Select "" Hi guys I'm trying to select the tag "" in the HTML file and it's not working here is source of the site:

Introducing the Manila Half Marathon happening on August 17, 2014 at the SM Mall of Asia Grounds. This race is for the benefit of the children of Virlanie

Sofitel Manila Half-Marathon 2014

August 17, 2014 @ 3AM

SM Mall of Asia

5K/10K/21K

Organizer: RunRio

Registration Fees:

21K – P950

10K – P850

5K – P750

here is my work so far:
doc = Jsoup.connect("http://www.pinoyfitness.com/2014/03/manila-half-marathon-august-17-2014/").timeout(0).get();
            Element bod = doc.body();
            Elements info = bod.select("br");
            String textString = info.text();

            System.out.println(textString);

I'm trying to retrieve the html code with the " " so that I can easily split them and format them.
but it when I select the element "P" it prints all the texts not including "" like this "Introducing the Manila Half Marathon happening on August 17, 2014 at the SM Mall of Asia Grounds. This race is for the benefit of the children of Virlanie Sofitel Manila Half-Marathon 2014 August 17, 2014 @ 3AM SM Mall of Asia 5K/10K/21K Organizer"
I'm new at JSOUP so please go easy on me if a have a newbee error or something like that. Thanks in advance.

A: If you want to preserve the
 tags in the parsed content, a somewhat simplistic solution to your problem would be to replace all
 tags in the original HTML code with text placeholders (a handy regexp to do it from here):
html.replaceAll("(?i)
]*>", "br2n")

Then you could do textString.split("br2n") if this is what you've been trying to achieve.

redpajama_set_name: RedPajamaStackExchange


Jordan Oil and West Bay Exploration (J/WB) want to lease city land (they have done so in Rochester Hills, Waterford, Springfield and Independence), homeowner's association common areas (they have done it in Brookdale Woods, Hunters Creek, and Shadow Woods), and private homeowners' land (door-to-door in our subdivisions).
The City of Rochester Hills leased three publicly owned properties to J/WB at the 35-acre Nowicki Park (near Tienken and Adams), 10 acre Tienken Park on the southwest corner of Rochester Adams High School, and the 10 acre Stony Creek Cemetery.
City Council/Mayor claim their Oct 2012 decision to lease city land was founded on the idea that entering into the J/WB contract would afford better financial gain and more control than not entering into the contract. Their lease likely violates the 2011 Parks Charter Amendment which states no city park or open space can be leased without a city-wide vote.
J/WB withdrew a similar offer to City of Rochester in October 2013 when concerned citizens demonstrated heavy opposition at Rochester's public hearing on their lease offer. Auburn Hills has not received an offer for a public land lease from J/WB, but J/WB is working through private landowners to identify a drill site.
To earn a drilling permit J/WB is subject to group decision. The DEQ requires a 40-acre parcel in order for developers to drill, with the well being 300-450 feet from any structure. By combining leases of city areas, common areas and then individual private land J/WB can build a majority of the land within the needed parcel. The City's leasing of 55 acres helped J/WB in pooling adjacent homes into the required parcel size. Ultimately, to get access to the non-leased land in their desired parcel, J/WB will request that the state create a "compulsory pool" which allows them to explore and drill under your property without consent. Therefore, each of you are voting for yourself and your neighbors if you lease your property mineral rights.
Generally, these operations consist of a wellhead within 1-2 miles of the potential resource pocket (e.g. under Nowicki Park), a 6" or larger pipeline from wellhead to storage tanks, a processing facility within 5 miles of the wellhead, and heavy trucks moving to and from the various sites. Currently, no one (but the oil companies) knows where any of these sites are being planned within the local area.
Drilling brings risks of spills, accidents, and pollution. These drilling efforts threaten health, safety, and property values. They also have significant mortgage and insurance implications, and will damage local infrastructure (e.g. truck traffic on secondary roads).
Concerned citizens are meeting with City and State officials frequently in an effort to build awareness, rescind the Rochester Hills lease, and ultimately prevent or mitigate the effects of oil/gas drilling in high density suburban neighborhoods.
I see barnett signs up on local homes. Do they not know what he did to the city of Rochester hills. How can we let these home owners know before the election?


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Igor Khaliulin, Raimondo Ascione, Leonid N Maslov, Haitham Amal, and Saadeh M Suleiman. 2021. "Preconditioning or Postconditioning with 8-Br-cAMP-AM Protects the Heart against Regional Ischemia and Reperfusion: A Role for Mitochondrial Permeability Transition." Cells, 10, 5. Abstract
The cAMP analogue 8-Br-cAMP-AM (8-Br) confers marked protection against global ischaemia/reperfusion of isolated perfused heart. We tested the hypothesis that 8-Br is also protective under clinically relevant conditions (regional ischaemia) when applied either before ischemia or at the beginning of reperfusion, and this effect is associated with the mitochondrial permeability transition pore (MPTP). 8-Br (10 $μ$M) was administered to Langendorff-perfused rat hearts for 5 min either before or at the end of 30 min regional ischaemia. Ca(2+)-induced mitochondria swelling (a measure of MPTP opening) and binding of hexokinase II (HKII) to mitochondria were assessed following the drug treatment at preischaemia. Haemodynamic function and ventricular arrhythmias were monitored during ischaemia and 2 h reperfusion. Infarct size was evaluated at the end of reperfusion. 8-Br administered before ischaemia attenuated ventricular arrhythmias, improved haemodynamic function, and reduced infarct size during ischaemia/reperfusion. Application of 8-Br at the end of ischaemia protected the heart during reperfusion. 8-Br promoted binding of HKII to the mitochondria and reduced Ca(2+)-induced mitochondria swelling. Thus, 8-Br protects the heart when administered before regional ischaemia or at the beginning of reperfusion. This effect is associated with inhibition of MPTP via binding of HKII to mitochondria, which may underlie the protective mechanism.
Bruria Hirsh Raccah PharmD PhD, Yevgeni Erlichman, Arthur Pollak, Ilan Matok, and Mordechai Muszkat. 2021. "Prescribing Errors With Direct Oral Anticoagulants and Their Impact on the Risk of Bleeding in Patients With Atrial Fibrillation." Journal of cardiovascular pharmacology and therapeutics, Pp. 10742484211019657. Abstract
INTRODUCTION: Anticoagulants are associated with significant harm when used in error, but there are limited data on potential harm of inappropriate treatment with direct oral anticoagulants (DOACs). We conducted a matched case-control study among atrial fibrillation (AF) patients admitting the hospital with a chronic treatment with DOACs, in order to assess factors associated with the risk of major bleeding. METHODS: Patient data were documented using hospital's computerized provider order entry system. Patients identified with major bleeding were defined as cases and were matched with controls based on the duration of treatment with DOACs and number of chronic medications. Appropriateness of prescribing was assessed based on the relevant clinical guidelines. Conditional logistic regression was used to evaluate the potential impact of safety-relevant prescribing errors with DOACs on major bleeding. RESULTS: A total number of 509 eligible admissions were detected during the study period, including 64 cases of major bleeding and 445 controls. The prevalence of prescribing errors with DOACs was 33%. Most prevalent prescribing errors with DOACs were "drug dose too low" (16%) and "non-recommended combination of drugs" (11%). Safety-relevant prescribing errors with DOACs were associated with major bleeding [adjusted odds ratio (aOR) 2.17, 95% confidence interval (CI) 1.14-4.12]. CONCLUSION: Prescribers should be aware of the potential negative impact of prescribing errors with DOACs and understand the importance of proper prescribing and regular follow-up.
Constantin Itin, Rinat Komargodski, Dinorah Barasch, Abraham J. Domb, and Amnon Hoffman. 2021. "Prolonged Delivery of Apomorphine Through the Buccal Mucosa, Towards a Noninvasive Sustained Administration Method in Parkinson's Disease: In Vivo Investigations in Pigs." Journal of Pharmaceutical Sciences, 110, 4, Pp. 1824–1833. Abstract
In the current work, prolonged systemic delivery of apomorphine via buccal mucosa was shown to be a promising treatment for Parkinson's disease as a substitute for clinically utilized subcutaneous infusions. Due to extensive 'first-pass' metabolism, apomorphine is administered parenterally to bypass liver metabolism. Drawbacks of parenteral administration cause low patient compliance and adherence to treatment. On the other hand, while also bypassing the liver, delivery through buccal mucosa has a superior safety profile, is less costly, lacks pain and discomfort, and possesses excellent accessibility, overall augmenting patient compliance. Current in vivo study in pigs showed: (1) steady plateau levels of apomorphine in plasma were obtained 30 min following administration and remained constant for 8 h until a delivery device was removed, (2) bioavailability of apomorphine was 55%–80% as opposed to <2% peroral and (3) simulation of the pharmacokinetic profile obtained in pigs predicted therapeutically relevant levels of apomorphine in human. Furthermore, antipyrine was incorporated as a permeation marker to enable mechanistic investigation of apomorphine release from the delivery device and its permeation through the buccal mucosa. In addition, limitations of an Ussing diffusion chamber as an ex vivo research tool were also discussed.
Madison N Myers, Maya Zachut, Joseph Tam, and Andres G Contreras. 2021. "A proposed modulatory role of the endocannabinoid system on adipose tissue metabolism and appetite in periparturient dairy cows." Journal of animal science and biotechnology, 12, 1, Pp. 21. Abstract
To sustain the nutrient demands of rapid fetal growth, parturition, and milk synthesis, periparturient dairy cows mobilize adipose tissue fatty acid stores through lipolysis. This process induces an inflammatory response within AT that is resolved as lactation progresses; however, excessive and protracted lipolysis compounds the risk for metabolic and inflammatory diseases. The suppression of lipolytic action and inflammation, along with amplification of adipogenesis and lipogenesis, serve as prospective therapeutic targets for improving the health of periparturient dairy cows. Generally, the activation of cannabinoid receptors by endocannabinoids enhances adipogenesis and lipogenesis, suppresses lipolysis, and increases appetite in mammals. These biological effects of activating the endocannabinoid system open the possibility of harnessing the endocannabinoid system through nutritional intervention in dairy herds as a potential tool to improve dairy cows' health, although much is still to be revealed in this context. This review summarizes the current knowledge surrounding the components of the endocannabinoid system, elaborates on the metabolic effects of its activation, and explores the potential to modulate its activity in periparturient dairy cows.
Bruria Hirsh Raccah, Alona Yanovsky, Nir Treves, Victoria Rotshild, Christel Renoux, Haim Danenberg, Ran Eliaz, and Ilan Matok. 2021. "Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) inhibitors and the risk for neurocognitive adverse events: A systematic review, meta-analysis and meta-regression." International journal of cardiology, 335, Pp. 7–14. Abstract
{BACKGROUND: It has been suggested that lipid lowering therapy causes impaired cognitive changes. The association between the use of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) inhibitors and the risk of neurocognitive adverse events remains unclear. This meta-analysis aims to assess neurocognitive safety of PCSK9 inhibitors in randomized controlled trials (RCTs). METHODS AND RESULTS: The research was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). PubMed (MEDLINE), Embase and Cochrane library were searched through September 2019. Selection criteria included RCTs that addressed to neurocognitive adverse events of participants using Alirocumab, Evolocumab or Bococizumab, with a follow up duration of at least 6 months. The search results were screened by two independent reviewers. Safety data from included papers were extracted. Random effects meta-analysis was used to pool results, and meta-regression was utilized when applicable. Twenty-one studies were included. Among 59,733 patients, 31,611 were treated with PCSK9 inhibitors. The follow-up period ranged from 24 weeks to 48 months. No significant difference in the incidence of neurocognitive adverse effects between the groups was identified (RR = 1.01, 95% CI: 0.86-1.19, I(2) = 3%). Similar results were seen in subgroup analysis for each of the medications (alirocumab- RR = 0.88, 95% CI: 0.72-1.08, I(2) = 0%, evolocumab- RR = 1.42, 95% CI: 0.74-2.73, I(2) = 55%). A meta-regression analysis for evolocumab revealed that prolonged study duration was associated with decreased risk for neurocognitive adverse events ($\beta$(week) = -0.0037
Victoria Nahum and Abraham J Domb. 2021. "Recent Developments in Solid Lipid Microparticles for Food Ingredients Delivery." Foods (Basel, Switzerland), 10, 2. Abstract
Health food has become a prominent force in the market place, influencing many food industries to focus on numerous bioactive compounds to reap benefits from its properties. Use of these compounds in food matrices has several limitations. Most of the food bio-additives are sensitive compounds that may quickly decompose in both food and within the gastrointestinal tract. Since most of these bioactives are highly or partially lipophilic molecules, they possess very low water solubility and insufficient dispersibility, leading to poor bioavailability. Thus, various methods of microencapsulation of large number of food bioactives have been studied. For encapsulation of hydrophobic compounds several lipid carriers and lipid platforms have been studied, including emulsions, microemulsions, micelles, liposomes, and lipid nano- and microparticles. Solid lipid particles (SLP) are a promising delivery system, can both deliver bioactive compounds, reduce their degradation, and permit slow and sustained release. Solid lipid particles have important advantages compared to other polymer carriers in light of their simple production technology, including scale up ability, higher loading capacity, extremely high biocompatibility, and usually low cost. This delivery system provides improved stability, solubility in various matrixes, bioavailability, and targeting properties. This article reviews recent studies on microencapsulation of selected bioactive food ingredients in solid lipid-based carriers from a point of view of production methods, characteristics of obtained particles, loading capability, stability, and release profile.
Wajeha Hamoudi, Felix von Lendenfeld, Maryam Kartawy, Shira Mencer, Huda Suloh, Igor Khaliulin, and Haitham Amal. 2021. "Regional Differences in S-Nitrosylation in the Cortex, Striatum, and Hippocampus of Juvenile Male Mice." Journal of Molecular Neuroscience. Abstract
Nitric oxide (NO) is a multifunctional neurotransmitter that plays a major role in neuronal and synaptic functions. S-nitrosylation (SNO), the NO-mediated protein posttransitional modification (PTM), is known to regulate physiological and pathological processes in the brain. However, the physiological role in different neuroanatomical brain regions has not been well investigated. To understand the role of SNO in the brain of juvenile WT mice, we used SNOTRAP technology. We mapped the SNO-proteome in three different neuroanatomical regions: cortex, striatum, and hippocampus. By conducting systems biology analysis, we found that the three brain regions share similar biological processes (BP) including biogenesis and developmental processes. Exclusive and different BP and molecular functions were found for each of the regions. Unraveling the BP and signaling mechanisms of SNO in the cortex, striatum, and hippocampus may help to understand the functional differences between the three regions under physiological conditions.
Saja Baraghithy, Yael Soae, Dekel Assaf, Liad Hinden, Shiran Udi, Adi Drori, Yankel Gabet, and Joseph Tam. 2021. "Renal Proximal Tubule Cell Cannabinoid-1 Receptor Regulates Bone Remodeling and Mass via a Kidney-to-Bone Axis." Cells, 10, 2. Abstract
The renal proximal tubule cells (RPTCs), well-known for maintaining glucose and mineral homeostasis, play a critical role in the regulation of kidney function and bone remodeling. Deterioration in RPTC function may therefore lead to the development of diabetic kidney disease (DKD) and osteoporosis. Previously, we have shown that the cannabinoid-1 receptor (CB(1)R) modulates both kidney function as well as bone remodeling and mass via its direct role in RPTCs and bone cells, respectively. Here we employed genetic and pharmacological approaches that target CB(1)R, and found that its specific nullification in RPTCs preserves bone mass and remodeling both under normo- and hyper-glycemic conditions, and that its chronic blockade prevents the development of diabetes-induced bone loss. These protective effects of negatively targeting CB(1)R specifically in RPTCs were associated with its ability to modulate erythropoietin (EPO) synthesis, a hormone known to affect bone mass and remodeling. Our findings highlight a novel molecular mechanism by which CB(1)R in RPTCs remotely regulates skeletal homeostasis via a kidney-to-bone axis that involves EPO.
Claire Thornton, Etty Grad, and Rami Yaka. 2021. "The role of mitochondria in cocaine addiction." Biochemical Journal, 478, 4, Pp. 749–764. Abstract
The incidence of cocaine abuse is increasing especially in the U.K. where the rates are among the highest in Europe. In addition to its role as a psychostimulant, cocaine has profound effect on brain metabolism, impacting glycolysis and impairing oxidative phosphorylation. Cocaine exposure alters metabolic gene expression and protein networks in brain regions including the prefrontal cortex, the ventral tegmental area and the nucleus accumbens, the principal nuclei of the brain reward system. Here, we focus on how cocaine impacts mitochondrial function, in particular through alterations in electron transport chain function, reactive oxygen species (ROS) production and oxidative stress (OS), mitochondrial dynamics and mitophagy. Finally, we describe the impact of cocaine on brain energy metabolism in the developing brain following prenatal exposure. The plethora of mitochondrial functions altered following cocaine exposure suggest that therapies maintaining mitochondrial functional integrity may hold promise in mitigating cocaine pathology and addiction.
Regina Leshem, Benjamin Bar-Oz, Orna Diav-Citrin, Siham Gbaly, Jessica Soliman, Christel Renoux, and Ilan Matok. 2021. "Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin Norepinephrine Reuptake Inhibitors (SNRIs) During Pregnancy and the Risk for Autism spectrum disorder (ASD) and Attention deficit hyperactivity disorder (ADHD) in the Offspring: A True Effect o." Current Neuropharmacology, 19, 6, Pp. 896–906. Abstract
{BACKGROUND AND OBJECTIVE: An inconsistent association between exposure to SSRIs and SNRIs and the risk for ASD and ADHD in the Offspring was observed in observational studies. Some suggest that the reported association might be due to unmeasured confounding. We aimed to study this association and to look for sources of bias by performing a systematic review and meta-analysis. METHODS: Medline, Embase, and the Cochrane Library were searched up to June 2019 for studies reporting on ASD and ADHD in the Offspring following exposure during pregnancy. We followed the PRISMA 2009 guidelines for data selection and extraction. Outcomes were pooled using random- effects models and odds ratios (OR), and 95% confidence intervals (CI) were calculated for each outcome using the adjusted point estimate of each study. RESULTS: Eighteen studies were included in the meta-analysis. We found an association between SSRIs/ SNRIs prenatal use and the risk for ASD and ADHD (OR=1.42, 95% CI: 1.23-1.65, I(2)=58%; OR=1.26, 95% CI: 1.07-1.49
Elka Touitou, Hiba Natsheh, Shatha Boukeileh, and Rania Awad. 2021. "Short Onset and Enhanced Analgesia Following Nasal Administration of Non-Controlled Drugs in Nanovesicular Systems." Pharmaceutics, 13, 7. Abstract
Nasal nanovesicular delivery systems (NVS) containing the noncontrolled analgesic drugs Ketoprofen, Butorphanol or Tramadol, incorporated in a phospholipid nanovesicular carrier, were designed and investigated. The systems were first characterized for their physicochemical properties. Due to their composition, comprising propylene glycol as a lipid bilayers fluidizer, these systems contain soft vesicles. Pharmacokinetic profiles of Tramadol in plasma and brain and of Ketoprofen in plasma were also assessed. The analgesic effect of each of the three tested drugs was evaluated in the acetic acid mice model for pain. One important result obtained in this work is that the concentration of Tramadol in rats' plasma and brain increased rapidly after administration, reaching a peak value 10 min after administration with a C(max) of 2 to 5 folds greater than that for the oral or nasal non-vesicular treatments, respectively. In the case of Ketoprofen, the peak of the drug level in plasma was measured 10 min post nasal administration in NVS. The C(max) was three-fold higher relative to oral administration of this drug. In the experiment testing analgesia, a rapid and improved analgesia was observed for the tested drugs when delivered nasally in the nanocarrier. On the other hand, a weaker analgesic effect was observed for oral and nasal control systems. This new approach suggests that nasal delivery of non-controlled drugs in soft nanovesicles may open the way for better and noninvasive treatment of severe pain.
Constantin Itin, Abraham J. Domb, and Amnon Hoffman. 2021. "On the Suitability of Porcine Labial Mucosa as a Model for Buccal Mucosal Drug Delivery Research." Journal of Pharmaceutical Sciences, 110, 4, Pp. 1863–1864. Abstract
Contrary to human, porcine mucosa of the inner side of the lip is parakeratinized. Thus, although desirable due to its large surface area, it does not closely resemble human buccal mucosa to be considered a suitable model for systemic drug delivery research. Nevertheless, it can be utilized for comparative screening of topical or systemic delivery of bioactive agents, mostly lipophilic such as cannabinoids.
Menachem Gross, Fadi Ashqar, Ronit Vogt Sionov, Michael Friedman, Ron Eliashar, Batya Zaks, Irith Gati, Danielle Duanis-Assaf, Mark Feldman, and Doron Steinberg. 2021. "Sustained release varnish containing chlorhexidine for prevention of Streptococcus mutans biofilm formation on voice prosthesis surface: an in vitro study." International microbiology : the official journal of the Spanish Society for Microbiology. Abstract
OBJECTIVES: In this study, we aimed to develop a novel, sustained release varnish (SRV) for voice prostheses (VP) releasing chlorhexidine (CHX), for the prevention of biofilm formation caused by the common oral bacteria Streptococcus mutans on VP surfaces. METHODS: This study was performed in an in vitro model as a step towards future in vivo trials. VPs were coated with a SRV containing CHX (SRV-CHX) or SRV alone (placebo-SRV) that were daily exposed to S. mutans. The polymeric materials of SRV were composed of ethylcellulose and PEG-400. Biofilm formation was assessed by DNA quantification (qPCR), crystal violet staining, confocal laser scanning microscopy (CLSM), scanning electron microscopy (SEM), and kinetics experiments. RESULTS: The amount of DNA in the biofilms formed by S. mutans on VP surfaces coated once with SRV-CHX (1.024 ± 0.218 ng DNA/piece) was 58.5 ± 8.8% lower than that of placebo-SRV-coated VPs (2.465 ± 0.198 ng DNA/piece) after a 48-h exposure to S. mutans (p = 0.038). Reduced biofilm mass on SRV-CHX-coated VPs was visually confirmed by CLSM and SEM. CV staining of SRV-CHX single-coated VPs that have been exposed to S. mutans nine times showed a 98.1 ± 0.2% reduction in biofilm mass compared to placebo-SRV-coated VPs (p = 0.003). Kinetic experiments revealed that SRV-CHX triple-coated VPs could delay bacterial growth for 23 days. CONCLUSIONS: Coating VPs with SRV-CHX has an inhibitory effect on biofilm formation and prevents bacterial growth in their vicinities. This study is a proof-of-principle that paves the way for developing new clinical means for reducing both VPs' bacterial biofilm formation and device failure.
Reem Odi, David Bibi, Bella Shusterman, Natalia Erenburg, Chanan Shaul, Claudiu T Supuran, Alessio Nocentini, and Meir Bialer. 2021. "Synthesis and Enantioselective Pharmacokinetic/Pharmacodynamic Analysis of New CNS-Active Sulfamoylphenyl Carbamate Derivatives." International journal of molecular sciences, 22, 7. Abstract
We recently reported a new class of carbamate derivatives as anticonvulsants. Among these, 3-methylpentyl(4-sulfamoylphenyl)carbamate (MSPC) stood out as the most potent compound with ED(50) values of 13 mg/kg (i.p.) and 28 mg/kg (p.o.) in the rat maximal electroshock test (MES). 3-Methylpropyl(4-sulfamoylphenyl)carbamate (MBPC), reported and characterized here, is an MSPC analogous compound with two less aliphatic carbon atoms in its structure. As both MSPC and MBPC are chiral compounds, here, we studied the carbonic anhydrase inhibitory and anticonvulsant action of both MBPC enantiomers in comparison to those of MSPC as well as their pharmacokinetic properties. Racemic-MBPC and its enantiomers showed anticonvulsant activity in the rat maximal electroshock (MES) test with ED(50) values in the range of 19-39 mg/kg. (R)-MBPC had a 65% higher clearance than its enantiomer and, consequently, a lower plasma exposure (AUC) than (S)-MSBC and racemic-MSBC. Nevertheless, (S)-MBPC had a slightly better brain permeability than (R)-MBPC with a brain-to-plasma (AUC) ratio of 1.32 (S-enantiomer), 1.49 (racemate), and 1.27 (R-enantiomer). This may contribute to its better anticonvulsant-ED(50) value. The clearance of MBPC enantiomers was more enantioselective than the brain permeability and MES-ED(50) values, suggesting that their anticonvulsant activity might be due to multiple mechanisms of action.
Maryam Kartawy, Igor Khaliulin, and Haitham Amal. 2021. "Systems Biology Reveals S-Nitrosylation-Dependent Regulation of Mitochondrial Functions in Mice with Shank3 Mutation Associated with Autism Spectrum Disorder." Brain sciences, 11, 6. Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental disorder manifested in repetitive behavior, abnormalities in social interactions, and communication. The pathogenesis of this disorder is not clear, and no effective treatment is currently available. Protein S-nitrosylation (SNO), the nitric oxide (NO)-mediated posttranslational modification, targets key proteins implicated in synaptic and neuronal functions. Previously, we have shown that NO and SNO are involved in the ASD mouse model based on the Shank3 mutation. The energy supply to the brain mostly relies on oxidative phosphorylation in the mitochondria. Recent studies show that mitochondrial dysfunction and oxidative stress are involved in ASD pathology. In this work, we performed SNO proteomics analysis of cortical tissues of the Shank3 mouse model of ASD with the focus on mitochondrial proteins and processes. The study was based on the SNOTRAP technology followed by systems biology analysis. This work revealed that 63 mitochondrial proteins were S-nitrosylated and that several mitochondria-related processes, including those associated with oxidative phosphorylation, oxidative stress, and apoptosis, were enriched. This study implies that aberrant SNO signaling induced by the Shank3 mutation can target a wide range of mitochondria-related proteins and processes that may contribute to the ASD pathology. It is the first study to investigate the role of NO-dependent mitochondrial functions in ASD.
Leslie Rebibo, Connie Tam, Yan Sun, Eve Shoshani, Amit Badihi, Taher Nassar, and Simon Benita. 2021. "Topical tacrolimus nanocapsules eye drops for therapeutic effect enhancement in both anterior and posterior ocular inflammation models." Journal of controlled release : official journal of the Controlled Release Society, 333, Pp. 283–297. Abstract
Tacrolimus has shown efficacy in eye inflammatory diseases. However, due to the drug lability, its formulation into a stable ophthalmic product remains a challenge. Tacrolimus-loaded nanocapsules (NCs) were designed for ocular instillation. Further, the stability and effects of the formulation were analyzed under different experimental conditions. Physicochemical characterization of the NCs revealed suitable homogeneous size and high encapsulation efficiency. Moreover, the lyophilized formulation was stable at ICH long term and accelerated storage conditions, for at least 18 and 3 months, respectively. The tacrolimus NCs did not elicit any eye irritation in rabbits after single- and multiple-dose applications. Additionally, ex vivo penetration assays on isolated porcine cornea and pharmacokinetics analyses in various rabbit eye compartments demonstrated the superiority of the NCs in retention and permeation into the anterior chamber of the eye compared to the free drug dissolved in oil. Moreover, multiple dose ocular instillation of the NCs in rats allowed high tacrolimus levels in the eye with very low plasma concentrations. Finally, the developed delivery system achieved a significant decrease in four typical inflammatory markers in a murine model of keratitis, an anterior chamber inflammation. Furthermore, these NCs, applied as eye drops, displayed clinical and histological efficacy in the mainly posterior chamber inflammation model of murine, experimental auto-immune uveitis.
Yuval Ramot, Michal Steiner, Netanel Amouyal, Yossi Lavie, Guy Klaiman, Abraham J. Domb, Abraham Nyska, and Tal Hagigit. 2021. "Treatment of contaminated radial fracture in sprague-dawley rats by application of a degradable polymer releasing gentamicin." Journal of Toxicologic Pathology, 34, 1, Pp. 11–22. Abstract
Fracture-related infections remain a leading cause of morbidity and mortality. We aimed to establish a simple contaminated radial osteotomy model to assess the efficacy of a biodegradable polymer poly(sebacic-co-ricinoleic acid) [p(SA-RA)] containing 20% w/w gentamicin. A unilateral transverse osteotomy was induced in Sprague-Dawley (SD) rats, followed by application of Staphylococcus aureus suspension over the fracture. After successfully establishing the contaminated open fracture model, we treated the rats either systemically (intraperitoneal cefuroxime), locally with p(SA-RA) containing gentamicin, or both. Control groups included non-contaminated group and contaminated groups that were either untreated or treated with the polymer alone. After 4 weeks, the bones were subjected to micro-CT scanning and microbiological and histopathology evaluations. Micro-CT analysis revealed similar changes in the group subjected to both local and systemic treatment as in the non-contaminated control group. Lack of detectable bacterial growth was noted in most animals of the group subjected to both local and systemic treatment, and all samples were negative for S. aureus. Histopathological evaluation revealed that all treatment modalities containing antibiotics were highly effective in reducing infection and promoting callus repair, resulting in early bone healing. While p(SA-RA) containing gentamicin treatment showed better results than cefuroxime, the combination of local and systemic treatment displayed the highest therapeutic potential in this model.
Aparna Anand, Abhinay Sharma, Miriam Ravins, Debabrata Biswas, Poornima Ambalavanan, Kimberly Xuan Zhen Lim, Rachel Ying Min Tan, Atul Kumar Johri, Boaz Tirosh, and Emanuel Hanski. 2021. "Unfolded protein response inhibitors cure group A streptococcal necrotizing fasciitis by modulating host asparagine." Science Translational Medicine, 13, 605, Pp. eabd7465. Abstract
Group A streptococcus (GAS) is among the top 10 causes of mortality from an infectious disease, producing mild to invasive life-threatening manifestations. Necrotizing fasciitis (NF) is characterized by a rapid GAS spread into fascial planes followed by extensive tissue destruction. Despite prompt treatments of antibiotic administration and tissue debridement, mortality from NF is still high. Moreover, there is no effective vaccine against GAS, and early diagnosis of NF is problematic because its clinical presentations are not specific. Thus, there is a genuine need for effective treatments against GAS NF. Previously, we reported that GAS induces endoplasmic reticulum (ER) stress to gain asparagine from the host. Here, we demonstrate that GAS-mediated asparagine induction and release occur through the PERK-eIF2$\alpha$-ATF4 branch of the unfolded protein response. Inhibitors of PERK or integrated stress response (ISR) blocked the formation and release of asparagine by infected mammalian cells, and exogenously added asparagine overcame this inhibition. Moreover, in a murine model of NF, we show that the inhibitors minimized mortality when mice were challenged with a lethal dose of GAS and reduced bacterial counts and lesion size when mice were challenged with a sublethal dose. Immunohistopathology studies demonstrated that PERK/ISR inhibitors protected mice by enabling neutrophil infiltration into GAS-infected fascia and reducing the pro-inflammatory response that causes tissue damage. Inhibitor treatment was also effective in mice when started at 12 hours after infection. We conclude that host metabolic alteration induced by PERK or ISR inhibitors is a promising therapeutic strategy to treat highly invasive GAS infections.
Roopesh Singh Gangwar, Hadas Pahima, Pier Giorgio Puzzovio, and Francesca Levi-Schaffer. 2021. "Update on Eosinophil Interaction with Mast Cells: The Allergic Effector Unit." Methods in Molecular Biology, 2241, Pp. 221–242. Abstract
Mast cells and eosinophils are the key effector cells of allergy [1]. In general, allergic reactions are composed of two phases, namely an early phase and a late phase, and after that resolution occurs. If the allergic reactions fail to resolve after the late phase, allergic inflammation (AI) can evolve into a chronic phase mainly involving mast cells and eosinophils that abundantly coexist in the inflamed tissue in the late and chronic phases and cross-talk in a bidirectional manner. We defined these bidirectional interactions between MCs and Eos, as the "allergic effector unit." This cross talk is mediated by both physical cell-cell contacts through cell surface receptors such as CD48, 2B4, and respective ligands and through released mediators such as various specific granular mediators, arachidonic acid metabolites, cytokines, and chemokines [2, 3]. The allergic effector unit can be studied in vitro in a customized co-culture system using mast cells and eosinophils derived from either mouse or human sources.


October 31st 2015: Manchester City 2 Norwich City 1.
A routine City win is marked by something that seems to augur well for the future. The first goal is a towering header by Nicolas Otamendi.
It's the beginning of the City career for the man hailed by many as 'the best defender in La Liga'. We signed him in August. He made his debut in September. He got off the mark in October.
In the weeks and months that followed, it became clear that it could be a while before we see a goal from our bearded Argentinian tough guy again.
That's because Nico's main chance of notching for us is from corners – and we are bad at corners.
Since that happy day, Dzeko has left to make hay at Roma, Kompany has mostly been on the sidelines and as a consequence City have resorted to taking corners short or getting Silva and KDB to launch away-swingers because most of our attacking players are, well – vertically challenged would be the kindest way of putting it.
Our biggest chap, Yaya Toure does not use his head to strike the ball. John Stones came along later but nodding in corners was not quite his forte either. For fans, the winning of a corner in our opponent's half was not really a cause for much excitement.
A mere two seasons later, Vincent Kompany returned and within just a couple of games, the big bustling Belgian showed us what we were missing when he nutted in the first recently against Southampton. In the same way that they say London buses rarely come alone but rather in twos and threes, such now seems to be the case with us, the corner kick set piece and the onion bag.
And lo and behold, Otamendi's back at it!
A short seventeen odd months after his stunner against the Canaries, yesterday's virtuoso performance against Palace was capped by that rarest of things: a header from a corner, and an Otamendi header at that!! It's as if Nicolas has been inspired by his partner and skipper who also scored yesterday.
Ladies and gentlemen, it seems very much as though all that was missing was for Otamendi to be back in good Kompany!
Guess who was Nico's defensive partner against Norwich back in 2015? That's right..
During this time, us Twitizens (City fans on Twitter) have been inspired by one particular supporter whose account name is @beardamendi. We all love @beardamendi.
With the never-say-die optimism of the most dogged national lottery contestant, 'beardy' vowed to post the video clip of Otamendi's goal at Norwich EVERY DAY until his hero scored again. Followers of @beardamendi have become used to seeing that goal in our newsfeeds with the ceaseless regularity of the rising of the sun. We loved the sheer relentless glass half-full chutzpah of our follicle-loving twitter pal.
That diving fifth that drew our applause yesterday added a healthy dollop of cement to our top 4 plans but of course after the euphoria receded, many soon realized that this might also mean the end of @beardamendi. His cellphone overheated with hundreds of messages of congratulation and there were soon calls for him to be rewarded with a signed shirt from his hero (gratifyingly, this has now happened!) But what next for our hero?
Whatever happens now, @boltfromthablue salutes the awesome patience of Twitizen beardamendi and intends to tell his story for years to come. We hope that he undertakes a new challenge on our behalf.
@beardamendi: I nominate you for entry in the MCFC hall of fame!
Posted in Match Reports, Opinions and tagged David Silva, Edin Dzeko, Kevin DeBruyne, Nicolas Otamendi, Pep Guardiola, Vincent Kompany. Bookmark the permalink.


I'm officially at the Healthy Living Summit! I arrived in downtown Chicago around 8:30am yesterday and made the huge mistake of walking to the hotel in sweltering heat while rolling my 50 pound bag. I was a complete sweaty mess by the time I arrived.
Because the room wasn't ready, I had to change out of my sweaty shirt in the lobby bathroom! I then headed off to the Frito Lay tour in Beloit, WI.
After a 2.5 hour bus ride, we finally arrived in Beloit. We listened to a short and very interesting presentation about the history and practices of the plant followed by a can and healthy lunch of wraps, salads, and fruit. This left me wondering, what about the chips? How can we be served lunch at Frito Lay and not have chips? Well, no sooner did I wonder than the chips were pulled out from under a surprise curtain! Plus, a variety of dips arrived just moments later.
Then, it was on to the tour. In small groups, we learned all about the process of turning potatoes into chips and corn into corn chips. What amazed me most about Frito Lay Was how much attention they put on health and quality. Seriously, many of there chip products only have 3 ingredients- corn or potatoes, salt, and oil – that's it! So simple (which, by the way, is their goal, to make their products with the simplest ingredients) and yet solo good.
My favorite part of the tour was sampling the hot doritos fresh off the line! Of course, hugging Chester Cheetah wasn't bad either. Plus, check out the swag bags!
Stay tuned for more conference deets!
It was great meeting you this weekend!


Hurricane Irma tore through the Caribbean and southeastern U.S. at the beginning of September, causing billions of dollars in property damage and claiming dozens of lives. Wind damage was responsible for much of this destruction, with trees taking down power lines all over the state of Florida. Nearly six million homes and businesses lost power, with some people going without for well over a week.
Even though Irma has passed, we still have nearly two months left in the Atlantic hurricane season. Another storm could hit Florida, and it's important to have a plan for what you'll do if your home or commercial property is damaged by wind.
Hindsight is 20/20, but you have an advantage during hurricane season: You have an idea of what could come. Prepare your home for the worst-case scenario by investing in hurricane-grade windows or shutters while the weather is calm. If you don't have hurricane shutters, consider boarding up your windows to help protect your home from wind damage.
If you've returned home after a storm and have wind damage your roof, broken your windows or caused debris to damage your property, time is of the essence. You'll likely be stressed and unsure what step to take next. Reach out to a qualified professional to determine how to best repair your property.
If your home is uninhabitable for the time being – or your business is unable to operate due to damage – it's crucial to decide what your next step will be. Reach out to your home insurance company to find out what they'll cover. It can be tempting to return home because of homesickness, but you must remain safe. Remember that tree branches and other debris can still fall even after a storm, so you shouldn't go home or back to work until an expert declares it safe to do so.
At Insurance Repair Specialists, Inc., we specialize in repairing damage caused by water, fire, wind, and mold. We are South Florida's premier property restoration company, and we can help you as you try to get back to normalcy. Contact our team at 954-725-2895 or click here to reach us.


To encourage Aboriginal and Torres Strait Islander young people to talk about mental health and wellbeing, communities in the Northern Territory have worked with headspace and Indigenous Hip Hop Projects (IHHP) to create the 'Got a lot going on' music video.
The hip hop video, written and performed by Aboriginal and Torres Strait Islander young people, captures the broad range of issues they are facing, including racism, stress, drugs and isolation, but stresses there is 'no shame in talking it'.
View the music video here and the behind the scenes video here .
The video was created over nine days in late 2014, with music and dance workshops held with young people in Rockhole, Katherine, Beswick and Belyuen.
Starting with just a beat, young people worked with IHHP and headspace to write song lyrics, learn hip hop dance moves and film the unique music video.
Dion Brownfield, Indigenous Hip Hop Projects, said nothing is more powerful than a resource made for young people, by young people.
"Communities will be able to relate and connect to the powerful messages in the lyrics. Indigenous young people do have many challenges living in community and they do have a lot going on, this music video is a testament to the power of culture, music and dance for change," Mr Brownfield said.
The most recent statistics released in the Australian Institute of Health and Welfare report (3/12/14) show suicide rates are almost twice as high among people of Aboriginal or Torres Strait Islander descent.
In addition, Aboriginal and Torres Strait Islander males and females aged 15-24 years are 5.2 times more likely to die due to intentional self-harm than other children and young people in the same age range.
headspace CEO Chris Tanti said the video has helped to bring the messages of the Yarn Safe campaign to life.
"The young people loved the process of using song and dance to express feelings and emotions. They weren't afraid to talk about what's going on for them even though they were touching on some really sensitive issues," Mr Tanti said.
The project is part of the ' Yarn Safe campaign', which aims to educate Aboriginal and Torres Strait Islander young people about mental health and encourage them to get help at headspace centres located around the country, eheadspace online and telephone counselling service or other appropriate mental health services.
'Yarn Safe' is the first youth-led national Aboriginal and Torres Strait Islander youth mental health campaign of its kind. The campaign was developed with a group of 12 Aboriginal and Torres Strait Islander young people from across Australia, including Elcho Island, Brisbane, Darwin, Broome, Melbourne and Perth.


text:
BLATCHFORD: An ignominious finale for country's top civil servant
Published: Mar 19 at 10:38 a.m.
Updated: Mar 20 at 4:09 p.m.
A week after news of the SNC-Lavalin imbroglio broke, Clerk of the Privy Council Michael Wernick gave a speech.
It was about a week before he testified for the first time at the House of Commons justice committee, where his opening remarks seemed unduly lurid for the country's top civil servant.
In particular, I refer to his fear that "the rising tides of incitements to violence" online could see "somebody … shot in this country this year, during the political campaign."
But on Feb. 14, Wernick was speaking at a conference for government communications specialists.
He spoke about the need for public servants "to be very mindful of our role as a public service that this and future governments will trust …
"… You are where the fresh water and the salt water meet: the boundary between a non-partisan public service and the partisan politics of a lively democracy.
"This is not always an easy place to be."
Monday, having sewn the seeds of confusion over how well or not he himself recognized that boundary, Wernick was swept away by those very same forces.
He announced his resignation, the fourth casualty of the SNC-Lavalin fiasco, the others being deposed attorney-general Jody Wilson-Raybould, former treasury board boss Jane Philpott, and Prime Minister Justin Trudeau's principal secretary, Gerry Butts.
Wernick alluded to "recent events" having led him to conclude he couldn't continue as clerk during the upcoming federal election.
"One of the key roles of the Privy Council Office is to be ready to assist whatever government Canadians elect in October.
"It has been my privilege to work with the transition teams of three prime ministers," he said. "It is now apparent that there is no path for me to have a relationship of mutual trust and respect with the leaders of the Opposition parties."
That's because various opposition members, including Conservative Leader Andrew Scheer and New Democratic ethics critic Charlie Angus, had called for Wernick to resign in the wake of his appearances at the justice committee. Angus said in an open letter to the PM that Wernick was "deeply compromised" and had "overstepped his role."
He also expressed concern that as a member of the newly formed "critical election incident public protocol," a panel given the task of alerting the public to serious cases of foreign interference in the October election, Wernick, as someone who Angus said had revealed himself to be "a clear political acto," couldn't purport to "sit above the election as someone that we should all trust…"
It was an ignominious finale to a 37-year career in the public service that saw Wernick hold senior executive positions in governments of Liberal and Conservative stripes and culminated in him taking over as clerk in 2016.
Though the full story of SNC-Lavalin's unofficial lobbyists (Wernick, Trudeau, Butts and other senior staff in the Prime Minister's Office) has yet to be told, even by Wernick's own testimony he was certainly an active part of it.
He serenely acknowledged having told Wilson-Raybould — well after her director of public prosecutions had decided SNC-Lavalin wouldn't get the deferred prosecution agreement, or DPA, it had been so ardently seeking for four years and Wilson-Raybould had decided not to overrule her — that her cabinet colleagues and the PM were quite concerned about the potential effects the SNC prosecution might have. He agreed that he wondered aloud whether a DPA was still an option.
His view was that yes, this was pressure, but merely pressure to get the decision right. He appeared oblivious to or unworried by the fact that the attorney-general is a creature like no other, meant to stand apart and independent, and that any pressure after she has made a decision is inappropriate.
(Wilson-Raybould described this meeting and a later phone call very differently and in much more ominous terms.)
As an indication of how Wernick saw himself, as a man of improbably high non-partisan standards, he told the justice committee that, why, he had walked out on a dinner at the National Arts Centre when he saw that SNC had bought a table.
Alas, he failed to mention (later, he said he'd been interrupted in giving his chronology of events) that he'd taken a call from one of his clerk predecessors, Kevin Lynch, now the chairman of SNC's board, who was making a last-ditch effort to get the company that DPA.
Wernick said he took the call because Lynch is the board chair, the "company is not a pariah" and besides, the DPA was still "a live issue."
When Conservative MP Lisa Raitt asked him, this at his second committee appearance, if he could understand how Canadians might be disturbed "to see that former clerks who are now chairs of boards of SNC-Lavalin have easy access and immediate access into the central office of this government," Wernick replied, "No."
Those were ringing words he told the government communications folks on Valentine's Day: "…Our whole system of democracy and the rule of law rests of trust, trust of the governed in their governments and trust that the system is fair.
"It may be noisy, it may not always work, but it is fair. The people have a say, and the people are heard. It is not rigged for any special interest."
Lovely words — not rigged for any special interest — but the conduct didn't match.
Kevin Lynch is on the line?
Oh well then.
• Email: cblatchford@postmedia.com | Twitter: blatchkiki
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It's an almost unquestioned assumption that written assignments need to be used to assess student learning. While traditional writing assignments are appropriate for many types of assessments, there is no law requiring it for all assessments. I've had students construct Wikipedia entries, make Voicethreads, and build online games as assessments.
Videos are another fun alternative to written assessments, and the latest technologies have made video creation remarkably easy. Video can be shot with a $200 flip camera, which provides very good sound and picture quality if a microphone is used. Even the ubiquitous smart phone provides remarkably good quality.
But production values are not the point, and poor production values can even add a layer of humor and authenticity to the project. The best advice is that if you are not Orson Wells, don't try to be. Attempting to reach movie studio quality only highlights the differences. Be self-referentially hokey as a way to make the lack of production values itself part of the production.
That said, your students' videos certainly will need some editing and tools such as Live Movie Maker (Windows) or iMovie (Mac) are free and relatively easy to use. Once your students are done editing and happy with the finished product, they can post it to YouTube for others to view. Vimeo and Screencast.com are other good places to post videos. There is no FERPA rule against students posting their work publically.
A good video assignment is to put students into small groups with instructions to make a video that teaches a key concept related to class. If done well, the video not only demonstrates students' understanding of the concept, but also serves as a resource that can be used by others. Often you will find that students are proud of what they produced and want to show it to friends, family, and maybe even future employers. When was the last time a student showed a written essay to anyone?
As usual, I welcome your comments, criticisms, and cries of outrage in the comments section of this blog post.


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An Inspirational Career: Celebrating Leslie Dixon
Baird honors the leadership, accomplishments and contributions of Leslie Dixon, who retired after a remarkable 35-year career with our Human Resources team in 2022.
"Leslie has served as a trusted confidant, an invaluable resource and friend to so many of us," said Steve Booth, Chairman, President & CEO. "Her leadership has helped ensure The Baird Way is at the core of our commitment to our clients, communities and each other."
Leslie joined Baird's newly formed human resources department in 1987 and was named Director of Human Resources in 1996, then Chief Human Resources Officer in 2004.
Recognizing the key role Baird's people make in what the firm and its clients describe as "The Baird Difference," Leslie modeled attributes and approaches to service and leadership that influenced and impacted many.
"I was lucky enough to be hired by Leslie and even luckier to be mentored by her throughout my career, said Katie Costigan, Private Wealth Management Market Director. "She taught me the art of handling difficult conversations, emphasizing that how we handle situations is just as important as the decision itself. She's selfless in her approach to all things, and she's tough as nails when faced with adversity."
As a longstanding member of Baird's Executive Committee, Leslie was integral to many of Baird's most important transformations over the years, including playing a lead role in Baird's consistent recognition among the Fortune 100 Best Companies to Work For since 2004.
In 2019, Leslie and Paul Purcell, Baird's former Chairman, President & CEO, shared their perspectives about Baird's No Asshole Rule with Canadian movie producer, John Walker for the documentary "Assholes: A Theory." Leslie and Beth Kavelaris, Director of Culture and Integration, were recently quoted in The New York Times, which also features the rule.
"Leslie encourages people to become the best versions of themselves," said Beth. "Her passion for the firm and her fellow associates is contagious. Baird would not be anywhere near the firm it is today without her."
In keeping with Baird's commitment to being a great place to work for all, Leslie has been a key player in the firm's inclusion and diversity initiatives. In 2009, she helped lead the formation of Associate Resource Groups (ARGs) at Baird. She then served as the Executive Sponsor of the Ascend ARG, which is dedicated to helping women at Baird achieve their full professional potential. The ARG's efforts were cited as part of Baird's recognition as one of the Best Workplaces for Women by Fortune and Great Place to Work in 2020 and 2021.
Leslie's wisdom and leadership made a difference beyond Baird as well. She was actively involved in the human resources committee for the Securities Industry Association, now called SIFMA, for more than 20 years and Chair of the group since 2009.
Throughout her tenure at Baird, Leslie received numerous accolades for her professional accomplishments and dedication to the firm's culture. In 2004, she was named a Women of Influence by the Milwaukee Business Journal and in 2018, she received the Great Place to Work For All Leadership Award from the Great Place to Work Institute. Most recently, Leslie was honored with the Lifetime Achievement HR Award from the Milwaukee Business Journal.
Leslie Dixon Receives Milwaukee Business Journal's Lifetime Achievement HR Award
Leslie Dixon, Chief Human Resources Officer at Baird, was honored with the 'Lifetime Achievement HR Award' by the Milwaukee Business Journal.
Women at Baird
At Baird, we're proud of our more-than-100-year history, and we know it is shaped by the women who help make it every day.


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Book review: Alexandre Reza
Born in Moscow, Alexandre Reza quickly conquered the City of Light – and then, the world – with the most exclusive jewelry. One of the world's most dignified jewelers, gemologists and legendary gem collectors is celebrated in this lavish Assouline edition.
Alexandre Reza, the book, is part of Assouline's Ultimate collection and is filled with original photography by Laziz Hamani and text by Vivienne Becker. According to David Bennett, chairman, Sotheby's international jewelry division, Europe and Middle East, who wrote the preface, the book is "the first major study devoted to the life and work of Alexandre Reza".
This edition presents more than one hundred rare pieces of Reza's creations. It also includes a history of the famed gem house in archival documents and vintage photography. Here we are able to observe in exuberant detail many vivid photos of several masterpieces from Reza's collection, whose colors capture our attention out of the pages.
See also: Book Review: Interior Design Philosophy by Jorge Canete
Reza was famed among his colleagues for the supreme order in which he kept his gemstones, each carefully labeled. "It is said he never forgot a stone out of the thousands he saw; he possessed an extraordinary faculty, a photographic memory for stones. After playing for hours with the gems, systematically arranging them into suites and designs, into a rhythmic flow of line, form, and color, it was the job of his assistants to put them back in immaculate order", Vivienne Becker refers in the book.
Reza's profession has always allowed him to be surrounded by exceptional beauty. "I have devoted my life to the study and appreciation of precious gems, revealing their true beauty. Perfection and artistic creation have always been my daily concerns", he says.
The precious diamonds, sapphires, emeralds and rubies reveal the clarity and intensity created by grouping particular gemstones, whose color and tones associations were powerful and carefully considered. They have seen the most extravagant centuries and epochs, from French monarchies, to Persian dynasties and to the Italian Renaissance.
History is an inspiration for Reza, who demonstrates a special affinity with the eighteenth century style. His handcrafted pieces mix ages and eras to create something special – a "harmonization of contradictory forces," according to historian Arlette Seta.
Assouline began with the belief that beauty can transform our lives, and that a book, artfully crafted and highly considered in its visual content, can open our eyes and minds; with Alexandre Reza we can perfectly feel it.
ABOUT THE AUTHOR: Alexandre Reza was born in 1922 in Moscow. He is a Paris-based jeweler known for a rare collection of precious gems, and lauded as the greatest gem collector of modern times. Son of a jeweler, he moved to France with his family when he was a child and began his career as a diamond expert, traveling extensively to source each stone, which served as the key design inspiration for his work.
Until he decided to launch his own unique and highly successful brand in the 1980s, the name Alexandre Reza was surprisingly little known outside of the jewelry industry.
Early on, Reza supplied gems to jewelry brands such as Boucheron, Bulgari, Cartier, Chaumet, Gerard, Harry Winston, and Van Cleef & Arpels. His eponymous jewelry house was founded in 1981 on the Place Vendôme, in Paris. Alexandre Reza's creations are known for their opulence, splendor, extravagance, and extraordinary craftsmanship.
See also: Books Review: Art & Makeup
Source: Coveted Magazine
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On 27 May 2013, ISIS Europe attended the presentation of the latest publication of the Centre for European Studies (CES) entitled "Breaking down the walls: improving EU-NATO relations". Hosted by the Konrad Adenauer Stiftung, the presentation included a roundtable discussion between Jamie Shea, NATO Deputy Assistant Secretary General for Emerging Security Challenges, Lauri Lepik, Ambassador of Estonia to NATO, Elmar Brok, Chair of the Committee on Foreign Affairs of the European Parliament, and Henna Hopia, Visiting Fellow at the Centre for European Studies and author of the report.
The future of the transatlantic relationship was brought back to the Brussels think tanks' agenda this week. Against the background of the current economic and financial hardship, the upcoming EU Defence Council of December 2013, and the silent ongoing review of the European External Action Service (EEAS), EU-NATO relations were this time approached with a particular focus on their European side. Henna Hopia built her argument on the improvement of EU-NATO relations on traditional ground; highlighting the common threats faced by both organisations, the need to avoid the duplication of capabilities especially at times of scarce resources, and the common operational framework of the EU and NATO, the need for cooperation was clearly presented.
The second part of the paper looks at the so-called "Building blocks of the wall": the Cyprus-Turkey issue, the inter-organisational competition and the EU's fragmentation in matters perpetrating to security and defence. In this respect, the diverging views of Member States, the CFSP's and CSDP's decision-making processes, the nationalistic interests of different EU Members and the daunting lack of a clear European strategy in the fields of security and defence are in the loop. As the European Security Strategy does not appear to fulfill its strategic purpose, or simply seems to be outdated, the questions on the geographical area of interest of the EU and its framework for action remain unanswered. Yet, talks about the EU's lack of strategic vision largely echo those abounding on NATO's perpetual crisis and its operations-driven transformation since the end of the Cold War. The European Union, thus, is not the only one facing identity issues; the challenges ahead of NATO after the 2014 withdrawal from Afghanistan have been underlined by Jamie Shea in his Carnegie Europe policy outlook "Keeping NATO relevant". In such a context, where can the relation between two organisations undergoing a strategic 'soul searching' go?
Jamie Shea recommended that the upcoming EU Summit should be seen as an opportunity for the EU to review its narrative on defence. He suggested that the Union should start building a convincing narrative on why and where armed forces are needed, which would lead to tackling the issue of the type of forces needed by the EU. Resolving internal incoherence and disputes is undoubtedly a step in the right direction for the improvement of the EU's external action, as well as for its cooperation with NATO. A similar questioning will apply to NATO once its troops return home from what has been a rather unpopular campaign in South Asia.
Ensuring the relevance of the EU and NATO is crucial. Yet, it will not be ensured for as long as these organisations and the government of the states that compose them do not manage to reach to their populations and provide them with a convincing and trustworthy defence narrative. Indeed, in a context where severe budget cuts directly affect citizens' everyday lives, while their perception of security at home is increasingly challenged, the need for a more open dialogue is pressing. EU Member States and the US cannot afford to increase the gap between governments and their citizens with controversial campaigns and unclear goals in remote parts of the world.
This entry was posted on 28/05/2013 by ISIS Europe in Conferences, Myrto Hatzigeorgopoulos and tagged Afghanistan, CSDP, EEAS, EU, EU Institutional Reform & Oversight, EU security, NATO, NATO reform, Transatlantic Security, US.


It would be hard to imagine any city with a more advantageous location for business than Chicago. Since its inception, the City of the Big Shoulders has proven to be a crucial link between the forests and mines to the north, the farms of the heartland, the coal fields to the south, and the urban population centers of the East Coast.
Chicago is a world-class city in every sense of the word. From legendary sports teams like "da Bears" to architecture that challenges possibilities, Chicago really does have it all.


Considering each element of the classic solitaire style, Jacob designed this ring as the perfect token of love for modern life. Sweeping delicate lines and 8 cupped prongs define this low-profile and effortlessly wearable ring. The delicate triple claw style prongs elegantly hold the center stone and add a touch of Old Hollywood glamour that is somehow also completely modern. Delicate 1mm pave adds additional sparkle.
14k White Recycled Gold Ring. Handcrafted in New York City. Ring Size 5.5 This ring can be resized.
Center Stone: 5.6mm Round Blue Montana Sapphire (Montana, USA).
Side Stones: Ten 1mm Round Brilliant Cut White Diamonds (Canada).


Small side table by Pastoe (not marked) and most probabley a design of Cees Braakman. The table comes from the oak series, and has a nice designed top and stands on oak legs. The condition is good considering the age, for details, see the photos. The size is 43 cm L / 43 cm W / 45 cm H.


Allan Klinge, Vice President of Klinge Corporation will serve on a panel at LogiChem, Europe's only conference dedicated to "supply chain as a business enabler".
Klinge Corporation will be participating in LogiChem, North America's leading event for chemical logistics and supply chain professionals. The two-day conference will address supply chain challenges including increased production and government regulations and will discuss best practices around supply chain integration, logistics strategy, metrics, and 3PL management.
Held from 3-4 November 2014 in Philadelphia, LogiChem is attended by executives and senior managers from leading chemical companies including Bayer MaterialScience, Nova Chemical, and Arkema as well as government officials from the US Environmental Protection Agency, National Transportation Safety Board, and the Federal Railroad Administration.
Participants will hear from leading executives that will provide strategies for reducing risk through supply chain resilience, improving forecasting accuracy, and making inventories leaner. The conference will include roundtables, panel discussions, keynote addresses, and networking opportunities.
Klinge Corporation will be presenting their Dual Refrigerated Containers that are specially designed for the chemical manufacturing industry. The containers have two reefer units, providing primary and back-up refrigeration for extra protection of valuable and temperature-sensitive chemicals.
The Dual Refrigerated Containers are available with additional fail-safes, including an integral generator set for back-up power, temperature recorder, and satellite communication system for remote monitoring of temperatures and other data.
Klinge Corporation made its first sale to the chemical industry nearly 30 years ago to meet the demand for a safe transport solution for organic peroxides, which are extremely volatile and exothermic (i.e. will combust if not properly cooled).
Klinge Corp will be exhibiting at the Council on Safe Transportation of Hazardous Articles (COSTHA) Annual Forum this week. The company will be educating participants on how their Dual Refrigeration Systems comply with United Nations' regulations on the transport of certain Dangerous Goods.


As it turned out, the bank did not have a business continuity plan for the foreign exchange trading desk at the time of the London terrorist attack in 2005. However, thanks to quick thinking by Stewart, the bank realized no major negative impact from leaving the London trading desk unattended, as all net positions were managed from the Paris and New York desks without any significant problems. Had he not given this direction, the operational interruption at the trading desk's location—with the marketplace in turmoil—would have cost the bank millions of pounds. This was a wake-up call.


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Praise for Labour's careers policy
The Labour Party's proposal to raise the status of careers guidance in schools has been welcomed by the education and training sectors. Under the new plan, every Year 9 student and above would receive a personalised career plan from a specifically trained careers advisor.
Labour Party leader Andrew Little announced the policy at the Industry Training Federation (ITF) AGM in Wellington. The policy is part of Labour's Future of Work Commission, a two-year project that will inform the party's new economic development policies.
"As the world of work changes, careers advice can no longer be seen as an add-on, delivered by already overstretched teaching staff," said Little.
"Our $30 million plan will partner schools with business and training providers to deliver up-to-date and relevant careers advice that prepares our young people for the future."
ITF chief executive Josh Williams welcomed the initiative, saying it would help bridge the skills gap.
"While thousands of young people are not in jobs, education or training, a number of industries are reporting acute skills and training shortages. Young people need sustainable careers and New Zealand needs skilled workers."
Secondary schools' union PPTA president Angela Roberts is pleased to see Labour's plan encompass all students and not just those at risk.
"Access to personalised advice rather than just generic information is what's really good about this. It's not just a website where students go and look at what careers earn the most. It's training people who are good at working with students to give them guidance that links to their needs," said Roberts.
The New Zealand Union of Student Associations (NZUSA) has also praised Labour's policy. The union describes New Zealand's careers system as "broken" and has called for the Education and Science select committee to undertake an inquiry into careers advice and transitions.