Sammy J has announced an additional Melbourne date on his Major Party tour for June and July 2019. By popular demand, the ABC satirical comedian has included another date at the iconic Athenaeum on June 28, only a week after he announced the two-month tour. Australia, are you ready to party? Because Sammy J is bringing all his characters, favourite songs and new sketches to the stage next year in one massive variety show.
When he is not delving deep into the minefield of political drama, Sammy J has been scoring himself ARIA Awards – he has three – and in 2018 released his debut novel, The Long Class Goodnight. As part of his weekly ABC TV shows, he snuck into Malcolm Turnbull's final press conference, just to eat a chocolate bar, and it's this attitude to fun,irreverence and smart silliness he will bring to Sammy J's Major Party.
It's a show that promises to have it all, harking back to the old school variety shows we love. Sammy J will have you singing along to Playground Politics, getting inspired by Government Coach, and flexing your core beliefs with some National Yoga(audience participation warning). It's a jam-packed night of song, stand-up and shenanigans, brought to you by the first person in history to have licked every Australian State and Federal Parliamentary building.


← I suppose this is about two varieties of fake people.
In which I pretend to be an art critic.
One of the best things about summer in the city is the vast amount of spare time I have to go to various museums that I am too busy to go to during the school year, and was too distracted by other things to go to last summer. Unfortunately, unlike in DC, they are not free, but whatever…that's what working out a budget is for.
So there are two exhibits I went to…one at the New Museum and one at the Met that were very similar in their concepts, except the one at the Met was TERRIBLE and the New Museum one was worth my $8.
The New Museum had an exhibit (now gone) called The Generational: Younger than Jesus which featured young artists under the age of 33 from all around the world, and their art which dealt with social issues facing people born since 1976. It was very high concept I suppose, as someone described it, but even though it was modern art utilizing different mediums (one installation was a lady in a bed) and on the surface some of the pieces could have come across as someone just throwing together a bunch of crap and calling it "Modern Art" (as is the stereotype) at least there was adequate explanation of the artists' background and statement so that the viewer could at least understand that the artist had a legitimate point…and the art generally did look like the artist had made some sort of effort.
On the other hand….the Met had an exhibit called The Pictures Generation and it was completely ridiculous. A lot of the art was just advertisements that the artist had altered in some small way, magazine cut outs…it wasn't even as if these were collages…it was like someone saw an ad they liked…took words from another ad and glued them together. The worst example were baby shoes an artist had bought with the intention of using them in a piece, but ended up selling them instead. And this was not a famous artist either. How is buying shoes art? Seriously…I am entertained by most exhibitions but I just don't understand art where the artists has made essentially zero effort and has created something with no purpose in mind and something that somebody without any talent could do. I should add that the museum did not include much explanation on what the intent of these artists were (unless I somehow managed to miss it), aside from "being affected by modern things" or whatever. Wow. So am I.
Sorry people. Dadaist art already happened, please don't try to recreate it.
Anyway, the Model as Muse exhibition, also at the Met, was 348732894723894 times better and everyone should go see that. They were really creative with their mannequins and have a lot of information on influential designers, photographers and models.


text:
Thousands of Genetically Modified Insects are set For Release
Thousands of Genetically Modified (GM) insects developed by British scientists are set to be released into fields across Europe as an alternative to chemical pesticides. Granted, pesticides have been responsible for jeopardizing human health, damaging the environment and killing millions of bees and other insects, but is the proper solution manufacturing genetically modified insects? The idea is to release a large number of GM olive flies that will be used to kill off wild pests that damage the crop. The company responsible for their manufacture and release is Oxitec. They plan to release GM male olive flies that would naturally mate with the females, ultimately resulting in the death of female offspring at the larvae or maggot stage. The thought is that this would lead to a reduction in the olive fly population, which would allow the trees to produce fruit without the need for chemical sprays.
Oxitec has applied to Spanish regulatory authorities for permission to carry out a netted field trial of its GM insects. If the trial is successful, more trials will be carried out in Greece and Italy- the company also eventually hopes to be able to use the GM insects in British fields as well.
Our approach is aimed not only at controlling the olive fly, but also to avoid harming other species. By using our form of genetic sterility our flies are designed to eliminate the pest and not to stay in the environment. – Oxitec's Dr Martha Koukidou (1)
In my view the use of GM insects to eradicate this pest is a necessary step towards achieving zero pesticide use. Critics of this technology who warn of danger to health and environment are scaremongering. European agriculture is facing some severe challenges. The burden of agricultural pests is ever present while the number of control approaches is shrinking in the face of insecticide resistance and de-registration of existing chemical treatments. To survive and prosper, European farming will need to evaluate and embrace new solutions and new technologies which are effective, sustainable and safe. If approved, this evaluation will be an important step to brining an exciting new approach to the farmers who need it- Hadyn Parry, Oxitec chief executive (1)
Supporters of the GM insects, like Oxitec, claim that those who oppose the idea are simply fear mongering. This is currently the same response from the big biotech giants to opposers of genetically modified foods. Recently, we have found out that opponents of genetically modified foods have been correct with their concerns, as multiple studies have surfaced over the past couple of years that indicated GMOs can be very harmful to the environment, as well as pose multiple risks to human health.
It's no different with these genetically modified insects, mosquitos to be exact, they've already been released into the public without a proper risk assessment.
Dr Helen Wallace, director of GeneWatch UK, warned:
Releasing Oxite's GM fruit flies is a deeply flawed approach to reducing numbers of these pests, because large numbers of their offspring will die as maggots in the fruit. Not only does this fail to protect the crop, millions of GM fruit fly maggots will enter the food chain where they could pose risks to human health and the environment. Oxitec's experiments should not go ahead until rules for safety testing and plans for labelling and segregation of contaminated fruits have been thoroughly debated and assessed. If these issues are ignored, growers could suffer serious impacts on the market for their crops.(1)
So what does this mean for animals that eat these flies as part of their routine diet? Or what about the humans that then eat these animals? Plans to commercialize GM insects would result in millions of GM insects being released onto field crops, including olives, tomatoes, citrus fruits, cabbages and cotton. Millions of GMO mosquitoes have already been released in experiments intended to reduce transmission of the tropical disease dengue fever, did you know about this? The release of GM insects are covered by laws and regulations that cover the release of genetically modified organisms (GMOs), however, there is no specific regulatory process for GM insects anywhere in the world. (2) (3)
Regulatory decisions on GM insects in Europe and around the world are being biased by corporate interests as the UK biotech company Oxitec has infiltrated decision-making processes around the world. The company has close links to the multinational pesticide and seed company, Syngenta. Oxitec has already made large-scale open releases of GM mosquitoes in the Cayman Islands, Malaysia and Brazil and is developing GM agricultural pests, jointly with Syngenta. (2)(3)
The public will be shocked to learn that GM insects can be released into the environment without any proper oversight. Conflicts of interest should be removed from all decision making processes to ensure the public have a proper say about these plans – Dr Helen Wallace, Director of GeneWatch UK (4)
The use of GM technologies is controversial. Some organizations such as GeneWatch UK and EcoNexus fear that reliance on high-tech solutions like genetic modification detracts from more effective but poorly deployed measures to combat the harm caused by insects. These are the companies we need to hear more about because they are the ones that directly monitor the use of genetic technologies. Environmental NGOs like Greenpeace suggest that GM insects could have unintended and wide ranging impacts on the environment and human health due to the complexity of ecosystems and the high number of unknown factors which make risk assessment difficult. These companies have raised a number of concerns which include (2):
New insects or diseases may fill ecological niche left by the insects suppressed or replaced, possibly resulting in new public health or agricultural problems
The new genes engineered into the insects may jump into other species, a process called horizontal transfer, causing unintended consequences to the ecosystem
Releases would be impossible to monitor and irreversible, as would any damage done to the environment
A briefing done by these organizations also shows that Oxitec is trying to influence regulatory processes for GM insects, that they (3):
Don't want to be liable for any complications
Try to avoid any regulation of GM agricultural pests on crops appearing in the food chain
Excludes important issues from risk assessments, like the impact on human health
Release of large amounts of GM insects prior to regulations
Undermining the requirement to obtain informed consent for experiments involving insect species which transmit disease
The list of concerns go on and on. This is something that you don't hear in corporate media, despite the importance of dialogue, it seems developments within this field are sneaking by very quietly. Should we not discuss this? Should there not be a proper risk assessment done? Concerning ourselves with our food, health and our environment is something we need to take very seriously. Developments that should attract a great deal of concern are happening without anybody knowing about them. These are some of the most important issues that our world faces today and some of the most important issues that will contribute in shaping the near future of our planet and the path we choose to take.
http://www.scientificamerican.com/article.cfm?id=genetically-engineered-mosquitoes
http://www.nature.com/nbt/journal/v29/n11/full/nbt.2019.html
(3)http://www.testbiotech.de/sites/default/files/Briefing%20genetically%20engineered%20Insects.pdf
(2)http://www.inasp.info/uploads/filer_public/2013/04/03/3_handout_1.pdf
(1)http://www.dailymail.co.uk/sciencetech/article-2410484/Scientists-launch-thousands-GM-insects-fields-alternative-chemicals.html
(4)http://farmwars.info/?p=9457
Obama Picks Drew Critcism From Members Of both Parties
The Senate approved a top federal judgeship on Thursday for an architect of the Obama administration's legal foundation for killing American terror suspects overseas with drones, as Democrats overcame opposition by Republicans and quelled concerns by some civil libertarians. By a near party-line 53-45 vote, senators confirmed David Barron to join the Boston-based 1st US Circuit Court of Appeals. Democratic Sens. Mary Landrieu of Louisiana and Joe Manchin of West Virginia were the only lawmakers to cross party lines and vote against the confirmation.
President Barack Obama's pick of Barron for the job last September drew criticism from members of both parties. It became a proxy fight over drone attacks on Americans abroad who the administration believed were terrorists, including those not on a battlefield. Also contentious was the administration's refusal to divulge documents showing why it believes it has the constitutional right to kill US citizens without trial.
Barron, a Harvard Law School professor, is the husband of gubernatorial candidate Juliette Kayyem.
"Today, the Senate confirmed my husband David J. Barron to the First Circuit Court of Appeals.," Keyyem said in a statement. "David is an exceptional lawyer, committed to public service and the law. He will be an amazing judge and, as his wife, I couldn't be prouder."
In 2009 and 2010, Barron was acting chief of the Justice Department's Office of Legal Counsel when he authored at least one such memo. His judgeship nomination gained steam this week after the administration declined to fight a federal appeals court order to release a censored version of one of his memos, though the document has yet to be made public.
On Thursday, Senate Judiciary Committee Chairman Patrick Leahy, D-Vt., mocked concerns he said some lawmakers have expressed about the possible US use of drones in places like Canada and Germany.
''Oh my God, talk about grasping at straws,'' Leahy said. ''We're dealing with reality here, not Alice in Wonderland.''
In a half-hour speech on Wednesday, Sen. Rand Paul, R-Ky., said it was unconstitutional for the government to kill Americans without due process of law. He said the right to trial is a given, even for unpopular defendants.
''It is easy to argue for trials for the high school quarterback or the American Idol winner,'' said Paul, a possible 2016 GOP presidential contender. ''It is hard to argue for trial for traitors and for people who would wish to harm our fellow Americans. But a mature freedom defends the defenseless, allows trials for the guilty, protects even speech of the most despicable nature.''
An unmanned US drone killed American-born Anwar al-Awlaki in Yemen in 2011. US officials considered al-Awlaki to be an inspirational leader of Al Qaeda, and they have also linked him to the planning and execution of several attacks targeting American and Western interests, including a 2009 attempt on Christmas Day on a Detroit-bound airliner.
Administration officials have acknowledged that three other Americans have been killed by drones but say they weren't specifically targeted.
Attorney General Eric Holder has said such killings are legal abroad if the targeted American poses an imminent threat to the US and cannot be captured.
Barron cleared a pivotal hurdle Wednesday when senators voted 52-43 to end opponents' efforts to derail the nomination.
No Fines For Dc Cops RUnning Red lights
California Police On Camera Fatally Shooting a Man
Residents of a small central California city are asking for a response from officials after the local police department has been attributed with fatally shooting two suspects in a span of just 11 days this month.
The Tuesday afternoon shooting death of man alleged to have attempted to burglarize a Salinas, CA home and then expose himself to the person inside marks the second time this month — and third time this year — that officers there have come under fire for what some are calling excessive force.
A local newspaper, the Monterey Herald, reported on Wednesday that Salinas residents were responding angrily to the previous day's incident in light of video footage published online showing local law enforcement officials firing the fatal shots at the man from point-blank range. The victim was not immediately identified by police.
According to the Herald, cops were alerted of an attempted break-in on Tuesday afternoon after a female caller told 911 that a man was not just trying to enter her home, but was trying to kill her dog and had exposed himself.
When police arrived and found the man on an adjacent street carrying a pair of gardening shears, the incident quickly escalated. The Herald quoted Salinas police Cmdr. Vince Maiorana as saying that the man was initially unresponsive when police tried to approach him about the alleged attempted break-in, then began to act strangely.
"Officers end up talking to this individual, trying to find out what he's doing and what the situation was based upon the original 911 call," Maiorana said. "This individual started to wave the gardening shears at the officers. We tried to deploy a Taser; the Taser did not work and as the officers tried to detain this individual, this individual pulled the gardening shears and actually attacked the officers with the gardening shears.
"In response, the officers, fearing for their personal safety, shot this individual and he is now deceased."
Cell phone video footage obtained by the paper shows that two officers with guns drawn and only a few feet away from the man fired four or five shots in broad daylight on Tuesday in a commercial part of Salinas, a town of roughly 154,000.
"There's some split-second decisions that have to be made by the officer," Maiorana told the Herald. "When the officer commanded this individual to drop the shears and to get down on the ground, this individual actually attacked the officer with the gardening shears."
According to the paper, though, witnesses — including the 19-year-old college student who captured the video footage of the shooting — disagree. The source of the Herald clip, Yoanna Prieto, said the man appeared to be backing away from police the entire time she was filming.
The Salinas Police Department is likely to have a harder time than ever justifying Tuesday's shooting, though, in the wake of an all-too similar incident that unfolded a week-and-a-half earlier.
On May 9, two Salinas cops fatally shot 26-year-old lettuce farmer Osman Hernandez outside of a grocery store only one mile away from the scene of this week's tragedy after he reportedly was chasing shoppers with a knife. Reports have since suggested Hernandez was drinking heavily at a nearby bar for two hours before the incident.
According to the man's family, at least one of the shots fired by law enforcement after the police arrived hit Hernandez in the head while he was lying on the ground.
"They killed Osman like a dog as he lay on the ground. Why are we to trust them investigating themselves? Why does it take so many bullets to the head to subdue a man who is already lying on the ground? Osman's life had value. We want the truth," a spokesperson for the man's family told reporters earlier this month.
KSBW added that the one eyewitness told the network that Hernandez was on the ground and stunned from the Taser when police fired no fewer than four shots. .
Christopher Dolan, a noted civil right attorney, told KSBW that the killing of his client "appears to be an excessive use of force resulting in a senseless killing."
"This is what is commonly referred to as a homicide," Dolan said. "The police state that they killed Mr. Hernandez for having a knife, not for actually threatening them with harm. Mr. Hernandez didn't even have a weapon in his hand when he was gunned down.The police, given the ultimate power by us, the citizens, owe each of us a duty to use only the minimum amount of force necessary. Officers are trained how to disarm a suspect and it's not by shooting them in the head over and over! This family deserves real answers so we will have private investigators speak with the witnesses, have Osman's body transferred to a private pathologist for analysis of the bullet trajectories, gunshot residue, and we will retain nationally renowned use of force experts to analyze the officers' conduct. It's in times like these when the police have killed someone that we need to be most vigilant as to protect ourselves from those entrusted to protect us."
Law enforcement up and down the West Coast have come under attack in recent years for a string of office-involved shootings and other acts of violence believed by some to demonstrate a trend towards using unnecessary force, but the comparably calm city of Salinas has endured three fatal police shootings alone so far in 2014.
"I understand there's a lot of emotions and a lot of legitimate concerns," Police Chief Kelly McMillin said during a City Council meeting on Tuesday with regards to that afternoon's shooting. "We're working hard to gather the facts, and when we have the facts, we will present them."
In late March, a man was shot to death by Salinas police officers after the cops responded to a report of a suspicious person who reportedly brandished a handgun when approached by law enforcement.
Feds Perparing to Arm TSA Workers?
The TSA has issued a solicitation requesting 24 million rounds of .357 SIG "duty ammunition" over a five year period, prompting fresh questions as to whether the federal agency is planning to arm its workers.
"Estimated quantity is approximately 4,800,000 rounds of .357 Sig duty ammunition per year, totaling 24,000,000 over the life of the contract," states the solicitation, posted on FedBizOpps, which adds that the ammo is for use at "DHS component locations nationwide."
The ammo purchase is likely to spark new questions about whether the Department of Homeland Security is preparing to arm TSA agents, an idea that has been pushed by the TSA's union, the American Federation of Government Employees, but has received scant support elsewhere.
Although Federal Air Marshals acting under the jurisdiction of the TSA are currently armed, other indications, such as the hiring of shooting ranges near airports, suggest the federal government could be preparing to arm some TSA workers. There are only 4,000 Federal Air Marshals currently operating in the United States, a figure that doesn't appear to match with the 4.8 million rounds a year the TSA is set to purchase under this solicitation alone.
The solicitation is filed under the auspices of the TSA and not another DHS agency such as Customs and Border Patrol.
"Outside of certain governmental organizations like the Federal Air Marshals, and the Secret Service, .357 Sig ammo is not a vastly popular round. It is basically a .40 caliber case necked down to accept a 9mm bullet. Who knows what it means, other than that a relatively small number of federal agents are expecting to do a whole hell of a lot of shooting, or they are expecting the ammo market to dry up for an extend period time," notes one blog.
An even more disturbing scenario would see armed DHS agents patrolling the streets of major cities like Chicago, as Jesse Jackson called for last year.
Fears that large ammunition purchases by the Department of Homeland Security may be linked to preparations for domestic unrest have raged over the past two years, although a recent Government Accountability Office investigation downplayed the issue as nothing out of the ordinary.
Another noteworthy aspect to the story is that the Department of Homeland Security has stopped referring to such ammunition as "hollow point," and is now referring to it as "duty" ammunition.
One of the DHS' explanations as to why it has been making ammo purchases in bulk quantities is in order to save money. However, previous solicitations for training ammunition requested "hollow point" rounds, which are not suitable for training and are more expensive than full metal jacket rounds.
More recently the DHS issued a solicitation for over 141,00 rounds of sniper ammunition, bullets known commercially as "Zombie Max," a reference to their high power.
Facebook @ https://www.facebook.com/paul.j.watson.71
Paul Joseph Watson is the editor at large of Infowars.com and Prison Planet.co

redpajama_set_name: RedPajamaCommonCrawl


Suzuki recently filed a trio of patents for a semi-automatic transmission that may have been developed for the upcoming, updated Hayabusa. Hideaki Takahashi—who has in the past filed patents for Suzuki transmissions—was credited for the three patents, one of which was filed in the US, another in Germany, and the last one in Suzuki's native Japan. Instead of just regurgitating other modern, semi-auto-moto offerings, Takahashi's patents reveal a pretty nifty new semi-automatic setup that mimics the new bike's traditionally manually-shifted brethren.
Takahashi's new patents show what is called an "automated manual transmission", or AMT, where the clutchless two-wheeler is shifted via a traditional left foot-pedal. Doing this relays a signal to the machine's ECU, telling it to initiate a gear change. Honda already offers at least one model (Africa Twin DCT) that offers a semi-automatic transmission that can be "shifted" via a pedal, but unlike the Honda, Suzuki's new shift-by-wire system sports what the patent describes as a "clicking mechanism", replicating the tactile sensation of changing gears on a traditional manual gear shift.
The filings show a system in which the clutch actuator is positioned just behind the crankcase, with the shift-actuator resting just above it. The semi-auto system also boasts small cylindrical elements labeled as little motors regulated via the bike's ECU. Honda's DCT system reportedly adds about 20 extra pounds to the bike's weight, so we can assume the Suzuki AMT system, though seemingly more compact, will add a few extra pounds to the 'Busa, a bike that already weighs in at 586.5 pounds (wet) in its current form.


Each CYSTAGON® Capsule contains 50 mg or 150 mg of cysteamine free base as cysteamine bitartrate. CYSTAGON® Capsules contain the following inactive ingredients: ammonium hydroxide, black iron oxide, colloidal silicon dioxide, croscarmellose sodium, gelatin, magnesium stearate, microcrystalline cellulose, pharmaceutical glaze, pregelatinized starch, propylene glycol, sodium lauryl sulfate and titanium dioxide.
Cystinosis is an autosomal recessive inborn error of metabolism in which the transport of cystine out of lysosomes is abnormal; in the nephropathic form, accumulation of cystine and formation of crystals damage various organs, especially the kidney, leading to renal tubular Fanconi Syndrome and progressive glomerular failure, with end stage renal failure by the end of the first decade of life. In four studies of cystinosis patients before cysteamine was available, renal death (need for transplant or dialysis) occurred at median age of less than 10 years. Patients with cystinosis also experience growth failure, rickets, and photophobia due to cystine deposits in the cornea. With time most organs are damaged, including the retina, muscles and central nervous system.
Cysteamine is an aminothiol that participates within lysosomes in a thiol-disulfide interchange reaction converting cystine into cysteine and cysteine-cysteamine mixed disulfide, both of which can exit the lysosome in patients with cystinosis.
Normal individuals and persons heterozygous for cystinosis have white cell cystine levels of < 0.2 and usually below 1 nmol/½ cystine/mg protein, respectively. Individuals with nephropathic cystinosis have elevations of white cell cystine above 2 nmol/½ cystine/mg protein. White cell cystine is monitored in these patients to determine adequacy of dosing, levels being measured 5 to 6 hours after dosing. In the Long-Term Study (see Clinical Trials, below) entry white cell cystine levels were 3.73 nmol/½ cystine/mg protein (range 0.13 to 19.80 nmol/½ cystine/mg protein) and were maintained close to 1 nmol/½ cystine/mg protein with a cysteamine dose range of 1.3 to 1.95 g/m2/day. After administration of cysteamine HCl, leukocyte cystine levels fall, with minimum levels at approximately 1 hour.
Because cysteamine HCl has an unpleasant taste and odor, other formulations have been developed, including phosphocysteamine, the phosphorothioester of cysteamine that is rapidly converted to cysteamine in the gut, and cysteamine bitartrate (CYSTAGON®). Cysteamine bitartrate has been shown in a transfer study in 8 patients to maintain white cell cystine levels below 1 nmol/½ cystine/mg protein when substituted for cysteamine HCl or phosphocysteamine. Total cysteamine levels 2 and 6 hours post-dosing were higher after cysteamine bitartrate than for the solutions.
The pharmacokinetics and pharmacodynamics of CYSTAGON® were studied in eleven pediatric patients with nephropathic cystinosis who received 225 to 550 mg of cysteamine bitartrate every 6 hours daily for more than one year. Following repeated oral administration of 225 to 550 mg cysteamine bitartrate, the mean time to maximum plasma concentration (Tmax) occurred at about 1.4 hours post dose with mean steady-state peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of 2.6 µg/mL and 6.3 µg∙hr/mL, respectively. The apparent volume of distribution and apparent plasma clearance of cysteamine were 156 L and 1.2 L/min, respectively.
Cysteamine was moderately bound to human plasma proteins, predominantly to albumin, with mean protein binding of about 52%. Plasma protein binding was independent of concentration over the concentration range achieved clinically with the recommended doses.
The pharmacodynamic response increased with the plasma cysteamine concentration, with maximum response occurring approximately 1.8 hours post dose with an average reduction of white cell cystine concentration of about 0.46 nmol/½ cystine/mg protein and returning to baseline level 6 hours post dose.
Most clinical data have been developed using cysteamine HCl or phosphocysteamine solutions. In all discussions that follow, administered amounts of various cysteamine salts will be expressed as amounts of cysteamine free base.
There are approximately 200 pre-transplant cystinosis patients in the United States with nephropathic cystinosis and clinical studies have included almost all of them, in addition to about 40 studied in the United Kingdom. For all patients, mean age at entry into studies was just under 4 years. Patients were approximately equally divided between genders and about 85% were white, 9% were black, and 3% were hispanic.
The National Collaborative Cysteamine Study (NCCS) treated 94 children (mainly from the United States) with nephropathic cystinosis with increasing doses of cysteamine HCl (mean dose 54 mg/kg/day) to attain white cell cystine levels of less than 2 nmol/½ cystine/mg protein 5 to 6 hours post-dose, and compared their outcome with an historical control group of 17 children who had been in the placebo group of a randomized placebo-controlled trial of ascorbic acid. Cysteamine treated patients had been diagnosed at a mean age of 22 months and were a mean age of 46 months old at study entry; placebo patients had been diagnosed at about 29 months and were a mean age of about 52 months old at study entry. The principal measures of effectiveness were serum creatinine and calculated creatinine clearance and growth (height).
The average median white cell cystine level attained during treatment in the NCCS was 1.7 ± 0.2 nmol/½ cystine/mg protein. There were 70 cysteamine patients with baseline serum creatinine less than 2 mg/dL who were followed for at least a year and 17 placebo patients. Twelve of the 94 cysteamine treated patients required early dialysis or renal transplant. Median follow-up of cysteamine patients was over 32 months and 20% were followed more than 5 years. For the placebo group median follow-up was 20 months and only one was followed more than 24 months. Among cysteamine patients glomerular function was maintained over time despite the longer period of treatment and follow-up. Placebo treated patients, in contrast, experienced a gradual rise in serum creatinine. Height, corrected for age, was compared for treated patients with the height, at the various ages patients appeared, of the 143 patients initially screened for inclusion in the NCCS. Patients on treatment maintained growth (did not show increasing growth failure compared to normals) although growth velocity did not increase enough to allow patients to catch up to age norms. Renal tubular function was not affected by treatment.
Calculated creatinine clearances were evaluated for two groups of children, one with poor white cell cystine depletion and one with good white cell cystine depletion as shown in Table I. The final mean creatinine clearance of the good depletion group was 20.8 ml/min/1.73 m2 greater than the mean for the poor depletion group, despite the older mean age of the good depletion group.
Median leukocyte cystine levels were over 3 nmol/½ cystine/mg protein or were not measured at least 2 times per year. Patients did receive cysteamine for at least 1 year.
Median leukocyte cystine levels were less than 1 nmol/½ cystine/mg protein and received cysteamine for at least 1 year.
The Long Term Study, initiated in 1988, utilized both cysteamine HCl and phosphocysteamine (patient's choice) in 46 patients who had completed the NCCS (averaging 6.5 years of treatment) and 93 new patients. Patients had cystinosis diagnosed by elevated white cell cystine (mean 3.63 nmol/½ cystine/mg). New patients and 46 continuing patients were required to have serum creatinine less than 3.0 mg/dL and 4.0 mg/dL, respectively. Patients were randomized to doses of 1.3 or 1.95 g/m2/day and stratified according to whether the serum creatinine was above 1.2 mg/dL or not. Doses could be raised if white cell cystine levels were approximately 2 nmol/½ cystine/mg protein and lowered due to intolerance.
Mean doses were 1.27 g/m2/day and 1.87 g/m2/day in the two groups and white cell cystine levels averaged 1.72 ± 1.65 nmol/½ cystine/mg protein and 1.86 ± 0.92 nmol/½ cystine/mg protein in the 1.3 and 1.95 g/m2/day groups, respectively. In new patients, a group similar in age to the NCCS group, serum creatinine was essentially unchanged over the period of follow-up (about half of the patients were followed for 24 months) and phosphocysteamine and cysteamine HCl had similar effects. The long-term follow-up group, about nine years old on average at entry, stayed in the study (almost 80% were followed at least 2 years) and had essentially no change in renal function. In four studies of untreated cystinosis, renal death (need for transplant or dialysis) occurred at median age of less than 10 years. Both groups maintained height (although they did not catch up from baseline). There was no apparent difference between the two doses.
CYSTAGON® is indicated for the management of nephropathic cystinosis in children and adults.
CYSTAGON® is contraindicated in patients who have developed hypersensitivity to it or to cysteamine or penicillamine.
If a skin rash develops, CYSTAGON® should be withheld until the rash clears. CYSTAGON® may be restarted at a lower dose under close supervision, then slowly titrated to the therapeutic dose. If a severe skin rash develops such as erythema multiforme bullosa or toxic epidermal necrolysis, CYSTAGON® should not be readministered.
CNS symptoms such as seizures, lethargy, somnolence, depression, and encephalopathy have been associated with cysteamine. If CNS symptoms develop, the patient should be carefully evaluated and the dose adjusted as necessary. Neurological complications have been described in some cystinotic patients not on cysteamine treatment. This may be a manifestation of the primary disorder. Patients should not engage in hazardous activities until the effects of CYSTAGON® on mental performance are known.
Gastrointestinal ulceration and bleeding have been reported in patients receiving cysteamine bitartrate. Physicians should remain alert for signs of ulceration and bleeding and should inform patients and/or guardians about the signs and symptoms of serious G.I. toxicity and what steps to take if they occur.
Post-marketing reports include one report of interstitial nephritis with early renal failure. A causal relationship between this event and cysteamine bitartrate therapy has not been established.
Gastrointestinal tract symptoms including nausea, vomiting, anorexia and abdominal pain have been associated with cysteamine, sometimes severe. In addition, gastrointestinal ulceration and bleeding have been reported in patients on cysteamine therapy. If these develop, therapy may have to be interrupted and the dose adjusted. A cysteamine dose of 1.95 grams/m2/day (approximately 80 to 90 mg/kg/day) was associated with an increased number of withdrawals from treatment due to intolerance and an increased incidence of adverse events.
Cysteamine has occasionally been associated with reversible leukopenia and abnormal liver function studies. Therefore, blood counts and liver function studies should be monitored.
There have been reports of benign intracranial hypertension (or pseudotumor cerebri; PTC) and/or papilledema associated with CYSTAGON® treatment that has resolved with the addition of diuretic therapy. PTC may be more common in cystinotic patients because of concurrent medication and renal transplantation. Although a causal relationship of PTC to CYSTAGON® has not been established, physicians should monitor patients receiving CYSTAGON® for this condition. Physicians should instruct patients to report any of the following symptoms: headache, tinnitus, dizziness, nausea, diplopia, blurry vision, loss of vision, pain behind the eye or pain with eye movement. A periodic eye examination is needed to identify this condition early and timely treatment should be provided when it occurs to prevent vision loss.
There have been reports of serious skin lesions in patients treated with high doses of CYSTAGON® or other cysteamine salts that have responded to cysteamine dose reduction. These skin lesions are purplish hemorrhagic lesions over the elbow area on both arms and have been described as molluscoid pseudotumors. Skin striae, bone lesions (that have been described as osteopenia, compression fractures, scoliosis and genu valgum) along with leg pain and joint hyperextension may also be present. One patient with serious skin lesions subsequently died of acute cerebral ischemia with marked vasculopathy. Physicians should routinely monitor the skin and bones of patients receiving CYSTAGON®. If similar skin or bone abnormalities appear, the dose of CYSTAGON® should be reduced.
See attached information for patients and parents and/or guardians.
Leukocyte cystine measurements are useful to determine adequate dosage and compliance. When measured 5 to 6 hours after CYSTAGON® administration, the goal should be a level < 1 nmol/½ cystine/mg protein. In some patients with poorer tolerability for CYSTAGON®, patients may still receive benefit with a white cell cystine level of less than 2 nmol/½ cystine/mg protein. Measurements should be done every three months, more frequently when patients are transferred from cysteamine hydrochloride or phosphocysteamine solutions to CYSTAGON®.
Physicians should follow patients for signs and symptoms of gastrointestinal ulceration and bleeding, and should inform patients and/or guardians of the importance of this follow-up.
None have been described. CYSTAGON® can be administered with electrolyte and mineral replacements necessary for management of the Fanconi Syndrome as well as vitamin D and thyroid hormone.
Cysteamine has not been tested for its carcinogenic potential in long-term animal studies.
Cysteamine was not mutagenic in the Ames test. It produced a negative response in an in-vitro sister chromatid exchange assay in human lymphocytes, but a positive response in a similar assay in hamster ovarian cells.
Repeat breeding reproduction studies were conducted in male and female rats. Cysteamine was found to have no effect on fertility and reproductive performance at an oral dose of 75 mg/kg/day (450 mg/m2/day, 0.4 times the recommended human dose based on body surface area). At an oral dose of 375 mg/kg/day (2,250 mg/m2/day, 1.7 times the recommended human dose based on body surface area), it reduced the fertility of the adult rats and the survival of their offspring.
Teratology studies have been performed in rats at oral doses in a range of 37.5 to 150 mg/kg/day (about 0.2 to 0.7 times the recommended human maintenance dose on a body surface basis) and have revealed cysteamine bitartrate to be teratogenic and fetotoxic. Observed teratogenic findings were cleft palate, Kyphosis, heart ventricular septal defects, microcephaly and exencephaly. There are no adequate and well-controlled studies in pregnant women. CYSTAGON® should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
It is not known whether cysteamine is excreted in human milk. Because many drugs are excreted in human milk and because of the manifested potential of cysteamine for developmental toxicity in suckling rat pups when it was administered to their lactating mothers at an oral dose of 375 mg/kg/day (2,250 mg/m2/day, 1.7 times the recommended human dose based on body surface area), a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
The safety and effectiveness of CYSTAGON® for cystinotic children have been established. Cysteamine therapy should be initiated as soon as the diagnosis of nephropathic cystinosis has been confirmed.
In three clinical trials, cysteamine or phosphocysteamine have been administered to 246 children with cystinosis. Causality of side effects is sometimes difficult to determine because adverse effects may result from the underlying disease.
The most frequent adverse reactions seen involve the gastrointestinal and central nervous systems. These are especially prominent at the initiation of cysteamine therapy. Temporarily suspending treatment, then gradual re-introduction may be effective in improving tolerance.
Adverse reactions were not collected systematically in the NCCS, but were often listed by investigators. The following rates may therefore be underestimated. The most common events (> 5%) were vomiting 35%, anorexia 31%, fever 22%, diarrhea 16%, lethargy 11%, and rash 7%.
Body as a whole: Dehydration.
Digestive: Nausea, bad breath, abdominal pain, dyspepsia, constipation, gastroenteritis, duodenitis, gastrointestinal ulceration and bleeding.
Central Nervous System: Somnolence, encephalopathy, headache, seizures, ataxia, confusion, tremor, hyperkinesia, decreasing hearing, dizziness, jitteriness.
Psychiatric: Nervousness, abnormal thinking, depression, emotional lability, hallucinations, nightmares.
Urogenital: Interstitial nephritis, renal failure (see WARNINGS).
Clinical Laboratory: Abnormal liver function, anemia, leukopenia.
Adverse reactions or intolerance leading to cessation of treatment occurred in 8% of patients in the U.S. Studies.
Withdrawals due to intolerance, vomiting associated with medication, anorexia, lethargy, and fever appeared dose related, occurring more frequently in those patients receiving 1.95 grams/m2/day as compared to 1.30 grams/m2/day.
Sudden deaths have been reported in this disease state.
Benign intracranial hypertension (or pseudotumor cerebri; PTC) with papilledema; skin lesions, molluscoid pseudotumors, skin striae, skin fragility; joint hyperextension, leg pain, genu valgum, osteopenia, compression fracture and scoliosis have been reported (see PRECAUTIONS).
CYSTAGON® has not been associated with abuse potential, psychological or physical dependence in humans.
A single oral dose of cysteamine at 660 mg/kg was lethal to rats. Symptoms of acute toxicity were reduction of motor activity and generalized hemorrhage in gastrointestinal tract and kidneys.
Two cases of human overdosage have been reported. In one case, the patient immediately vomited the drug and did not develop any symptoms. The second incident involved an accidental ingestion of a 200 to 250 mg/kg dose by a healthy 13 month old child. Vomiting and dehydration were experienced. The child was hospitalized and fluids were administered. A full recovery was made. Should overdose occur, the respiratory and cardiovascular systems should be supported appropriately. No specific antidote is known. Hemodialysis may be considered since cysteamine is poorly bound to plasma proteins.
For the management of nephropathic cystinosis, cysteamine therapy should be initiated promptly once the diagnosis is confirmed (i.e., increased white cell cystine).
New patients should be started on ¼ to 1/6 of the maintenance dose of CYSTAGON®. The dose should then be raised gradually over four to six weeks to avoid intolerance.
The recommended CYSTAGON® maintenance dose for children up to age 12 years is 1.30 grams/m2/day of the free base, given in four divided doses. Intact CYSTAGON® capsules should not be administered to children under the age of approximately six years due to the risk of aspiration. CYSTAGON® capsules may be administered to children under the age of approximately six years by sprinkling the capsule contents over food. Patients over age 12 and over 110 pounds weight should receive 2.0 grams/day, divided four times daily.
If a dose is missed, it should be taken as soon as possible. If it is within two hours of the next dose, skip the missed dose and go back to the regular dosing schedule. Do not double dose.
When CYSTAGON® is well tolerated, the goal of therapy is to keep leukocyte cystine levels below 1 nmol/½ cystine/mg protein five to six hours following administration of CYSTAGON®. Patients with poorer tolerability still receive significant benefit if white cell cystine levels are below 2 nmol/½ cystine/mg protein. The CYSTAGON® dose can be increased to a maximum of 1.95 grams/m2/day to achieve this level. The dose of 1.95 grams/m2/day has been associated with an increased rate of withdrawal from treatment due to intolerance and an increased incidence of adverse events.
Cystinotic patients taking cysteamine hydrochloride or phosphocysteamine solutions may be transferred to equimolar doses of CYSTAGON® capsules.
The recommended maintenance dose of 1.30 grams/m2/day can be approximated by administering CYSTAGON® according to the following table, which takes surface area as well as weight into consideration.
Patients over age 12 and over 110 pounds should receive 2.0 grams/day given in four divided doses as a starting maintenance dose. This dose should be reached after 4 to 6 weeks of incremental dosage increases as stated above. The dose should be raised if the leukocyte cystine level remains > 2 nmol/½ cystine/mg/protein.
Leukocyte cystine measurements, taken 5 to 6 hours after dose administration, are recommended for new patients after the maintenance dose is achieved. Patients being transferred from cysteamine hydrochloride or phosphocysteamine solutions to capsules should have their white cell cystine levels measured in 2 weeks, and thereafter every 3 months to assess optimal dosage as described above.
If CYSTAGON® is poorly tolerated initially due to gastrointestinal tract symptoms or transient skin rashes, therapy should be temporarily stopped, then re-instituted at a lower dose and gradually increased to the proper dose.
PHARMACIST: Detach Patient Information Leaflet at each perforation and give leaflet to patient.
The following information is available for patients and/or guardians in the patient leaflet.
Read the Patient Information that comes with CYSTAGON® before you or your child starts taking it and each time you get a refill. There may be new information. This leaflet does not take the place of talking with your doctor about your or your child's medical condition or treatment.
CYSTAGON® is a medicine used to manage a medical condition called nephropathic cystinosis, in children and adults.
Nephropathic cystinosis is a rare inherited condition which causes the build up of a protein building block called cystine in the kidneys. The build up of cystine causes kidney problems. These kidney problems cause the body to lose too much sugar (glucose), proteins, and electrolytes. Cystinosis may lead to slow body growth, weak bones and worsening kidney failure.
Who should not take CYSTAGON®?
Do not take CYSTAGON® if you or your child is allergic to any of the ingredients in it, other products containing cysteamine, or penicillamine. See the end of this leaflet for a complete list of ingredients in CYSTAGON®.
What should I tell my or my child's doctor before taking CYSTAGON®?
have had an allergic reaction to a medicine containing cysteamine in the past.
are pregnant or plan to become pregnant. It is not known whether CYSTAGON ® may harm your unborn baby. Do not take CYSTAGON ® during pregnancy unless you and your doctor decide that the possible benefit of taking CYSTAGON ® is more important than the risk to an unborn baby.
It is not known if CYSTAGON ® will pass into breast milk. You and your doctor should decide whether to stop nursing or to stop taking the medicine.
Know the medicines you or your child takes. Keep a list of your or your child's medicines and show it to your or your child's doctor and pharmacist when you get a new medicine.
How should CYSTAGON® be taken ?
Take CYSTAGON® exactly as prescribed. Do not increase or decrease the amount of medicine without your doctor's approval.
If you or your child takes too much CYSTAGON ®, call your doctor or Poison Control Center, or go to the nearest hospital emergency room right away.
Do not give CYSTAGON ® capsules to children under six years of age. They may not be able to swallow them and may choke. For children under six years of age, the capsule may be opened and the contents sprinkled on food. Talk to your doctor for complete directions.
Your doctor will arrange for regular blood tests to be done to measure the amount of cystine inside white blood cells. This will help to determine the correct dose of CYSTAGON ®. Regular blood and urine tests will also be done to measure the levels of the body's important electrolytes. This will help your doctor to correctly adjust the doses of these supplements.
What should I or my child avoid while taking CYSTAGON®?
CYSTAGON® may cause some people to become sleepy or less alert than they are normally. You or your child should not drive, operate machinery, or do other dangerous activities until you know how CYSTAGON® affects you.
What are the possible side effects of CYSTAGON®?
Skin rash. Tell your doctor right away if you or your child gets a skin rash. CYSTAGON ® may need to be temporarily stopped until the rash goes away. If the rash is severe, your doctor may totally stop the CYSTAGON ®.
Central nervous system symptoms: Some patients taking cysteamine have developed seizures, depression, and become too sleepy (excessive sleepiness). Tell your doctor if you or your child has these symptoms.
Stomach and intestinal (gastrointestinal) problems: Patients taking cysteamine have developed ulcers and bleeding. Tell your doctor right away if you or your child get stomach pain, nausea, vomiting, loss of appetite, or throw up blood.
Benign intracranial hypertension, also called pseudotumor cerebri, has been reported. This is a condition where there is high pressure in the fluid around the brain. Tell your doctor right away if you or your child develop any of the following symptoms while taking CYSTAGON ®: headache, buzzing or "whooshing" sound in the ear, dizziness, nausea, double vision, blurry vision, loss of vision, pain behind the eye or pain with eye movement. Your doctor will monitor you or your child with eye examinations to find and treat this problem early. This will help lessen the chance of loss of eyesight.
Skin lesions, bone lesions, and joint problems. Children treated with high doses of cysteamine may develop skin lesions. These include skin striae (which are like stretch marks), bone injuries (such as fractures), bone deformities, and joint problems. Examine your or your child's skin while taking CYSTAGON ®. Report any changes to your doctor. Your doctor will monitor you or your child for these problems.
How should I store CYSTAGON®?
Store CYSTAGON ® in a dry place away from light.
Store CYSTAGON ® between 68° to 77°F (20° to 25°C).
Keep CYSTAGON® and all medicines out of the reach of children.
Medicines are sometimes prescribed for conditions that are not mentioned in the patient leaflet. Do not use CYSTAGON® for a condition for which it was not prescribed. Do not give CYSTAGON® to other people, even if they have the same symptoms that you or your child have. It may harm them.
This patient information summarizes the most important information about CYSTAGON®. If you would like more information about CYSTAGON®, talk with your doctor. You can ask your doctor or pharmacist for information about CYSTAGON® that is written for health professionals. For more information call 1-877-446-3679.
What are the ingredients in CYSTAGON®?
Active ingredient: cysteamine free base as cysteamine bitartrate.
Inactive ingredients: ammonium hydroxide, black iron oxide, colloidal silicon dioxide, croscarmellose sodium, gelatin, magnesium stearate, microcrystalline cellulose, pharmaceutical glaze, pregelatinized starch, propylene glycol, sodium lauryl sulfate and titanium dioxide.
and Parent Information Leaflet to each patient.
to 50 mg of cysteamine.
to 150 mg of cysteamine.


2010: The Dragons are Back!
The Cincinnati Dragons blew out the Miami Soul 162-102 to win their league leading 4th XFFL Championship. The Cincinnati Dragons would move to Columbus following the victory.
2010 would be the first year of the Atlanta Predators in the XFFL.
For the first time in league history a team would be forced out half way through a season. After an 0-6 start, the Glendale Nighthawks and Adam Barnhardt were given the boot for their dismal performances. They would be replaced immediately by Josh Hopper and the Philadelphia Blizzard. This would be the Blizzard's second stint in the XFFL.
The most successful team in XFFL history, the Cincinnati Dragons, would be moved north to Columbus after the 2010 season.
Tampa Bay wasn't the answer to the question Owner Dave Hopper was searching for as he was looking for the proper city to call home for his XFFL franchise.


Ossorio came from a wealthy Philippine family. His father, a banker by trade, created modern sugar milling, and both Domino and Jack Frost depended on his operation for their processed sugar. He was also prescient, and in anticipation of World War II he moved his family to the United States in 1930, when Ossorio was 14. Alfonso was naturalized three years later.
While still a teenager, he not only began to make art seriously, studying wood engraving with Eric Gill in England, he also began collecting the work of Gill and other members of the Arts and Crafts movement in England.
That generosity continued throughout Ossorio's life. Mr. Solomon made the point that he was an artist-collector who was able to buy works he wanted to study. Moreover, he had no shame about borrowing techniques and ideas from people he admired, foremost among whom was Jackson Pollock.
He bought Pollock's "No. 5, 1948" from Betty Parsons in 1949. When he discovered that a chip of paint had come off the canvas, he called the artist, who said he should bring the painting to East Hampton so he could fix it. "The rest is history," said Mr. Solomon.
Ossorio first bought Jean Dubuffet's paintings in 1947, and the artists became friends in 1949. Dubuffet was a collector as well as an artist, and he had amassed more than 700 pieces of art brut, or outsider art. Dubuffet's holdings were exhibited on a rotating basis at the Creeks from 1952 to 1962, and their influence can be seen in Ossorio's work.
The Creeks had a cultural history that predated Ossorio. Albert and Adele Herter, who built the house in 1899 and occupied it until the Hurricane of 1938 flooded the pond and house, counted among their friends William Merritt Chase and Thomas and Mary Nimmo Moran. Isadora Duncan took their gondola onto Georgica Pond, and Caruso sang in the music room.
The parade of cultural notables continued throughout Ossorio's time there, with Jasper Johns, Louise Nevelson, Claes Oldenburg, Andy Warhol, Marcel Duchamp, and Mark Rothko among the celebrated artists and Clement Greenberg, Harold Rosenberg, and Tom Hess among the critics.
Mr. Solomon, who grew up between East Hampton and Sarasota, Fla., now divides his time between studios on the North Fork and in Sarasota. An exhibition of his paintings and works on paper is on view at the library through Oct. 12.


text:
Gomphonema ist eine Gattung der Kieselalgen (Bacillariophyta) mit etwa 100 Arten im Süßwasser.

Merkmale
Die Vertreter sind einzellige Kieselalgen, die vorwiegend an einfachen oder verzweigten Gallertstielen festsitzen. Die Zellen haben die für Kieselalgen typische Schale aus zwei Theken. Die Schale ist in Seitenansicht keilförmig, in Schalenansicht besteht sie aus zwei unterschiedlichen Zellpolen: der schmale Fußpol befindet sich am Gallertstiel, der breitere ist der Kopfpol. Jede Zelle enthält einen großen, H-förmigen Plastiden mit zentralem Pyrenoid. Der Plastid ist durch Fucoxanthin goldbraun gefärbt, seine Lappen liegen unter den Schalen. Beide Schalen besitzen eine deutliche, mittig liegende Raphe. Die Zellen sind 8 bis 130 Mikrometer lang.

Die ungeschlechtliche Fortpflanzung erfolgt durch die typische Zweiteilung der Kieselalgen. Geschlechtliche Fortpflanzung erfolgt durch Anisogamie, wobei pro Zelle zwei Gameten gebildet werden. Im Anschluss erfolgt während der Auxosporenbildung die Zellvergrößerung.

Vorkommen
Gomphonema lebt vorwiegend am Substrat angeheftet. Sie kommen in stehenden oder nur schwach fließenden Gewässern, unabhängig vom Nährstoffgehalt, vor.

Belege
 Karl-Heinz Linne von Berg, Michael Melkonian u. a.: Der Kosmos-Algenführer. Die wichtigsten Süßwasseralgen im Mikroskop. Kosmos, Stuttgart 2004, ISBN 3-440-09719-6, S. 218.

Weblinks

 Gomphonema auf algaebase.org

Kieselalgen
Bacillariophyta

redpajama_set_name: RedPajamaWikipedia


text:
Wish comes true as Syrian refugee teen meets Trudeau
By National Observer in News, Politics | December 19th 2017
#28 of 34 articles from the Special Report: Syrian Refugees in Canada
Syrian refugee Marwa Harb met with Prime Minister Justin Trudeau on Monday, December 18, 2017. Photo provided by the Children's Wish Foundation
A 15-year-old Syrian refugee who came with her family to Canada in 2016 thanked Prime Minister Justin Trudeau in person this week.
"I sincerely hoped to be able to meet and personally thank the person who has given my family and I the opportunity to start a new life filled with endless possibilities," Marwa Harb said in a media release issued by The Children's Wish Foundation, which organized the meeting.
Harb has congenital myopathy and severe scoliosis. The Children's Wish Foundation says that, in Canada, she is able to receive "life-altering treatment," go to school and learn English.
Trudeau said on his Twitter account that it was a pleasure to host the family on Parliament Hill and that he was touched by Harb's story.
What a pleasure to host the Harb family on the Hill today. Marwa, I was touched by your story and I'm so glad you & your family are getting the support you need in Halifax. My thanks to @Childrens_wish for making today's visit a reality. pic.twitter.com/KCHwXzJ4DD
— Justin Trudeau (@JustinTrudeau) December 18, 2017
Approximately 40,000 Syrian refugees have come to live in Canada since 2015.ing today's visit a reality.
Services provided, but outcomes not tracked for Syrians: auditor general
By Stephanie Levitz in News, Politics | November 22nd 2017
Syrian Refugees in Canada
War on the playground: when children act out divisions from battles left behind
By Jenny Uechi in News | November 15th 2017
Canada to admit 340,000 immigrants a year by 2020 under new three-year plan
By Stephanie Levitz in News, Politics | November 4th 2017


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My family has had a tradition of having fondue of Christmas Eve for as long as I can remember–probably since fondue's heyday in the 70's!
Ha ha. We gather on Christmas Day, but I would say that fondue is the high point of our holiday.
We dip our main course items in cheese.
There's a legend that we've tried hot oil for cooking meat, but I don't remember that. It sounds too scary around small children.
Sometimes, someone will bring a marinade for the lactose intolerant, but the main feature is cheese.
There are many good recipes online, but we just melt down a few blocks of farmhouse cheddar from Hickory Farms and thin it with some milk.
Carrots, tomatoes, mushrooms, broccoli, cauliflower, Potatoes, Ham, steak, beef stick, turkey stick, brown and serve sausages.
After cheese, we go to church, and when we come back, it's a Christmas Eve Fondue Party!
The cheese fondue is a formal candlelit meal with china and crystal, but for chocolate we ring the room with chairs, invite some friends, play games, and eat on fun holiday paper plates.
Our chocolate is just melted down chocolate chips; sometimes in recent years we have also used a chocolate fountain.


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Blue Jays-Yankees Series Preview
The Yanks and Jays have at it for three in the Bronx. New York just lost two of three to Seattle and Toronto has won four straight against the Red Sox and Giants respectively. Here is a series preview.
After going 6-2 on the road in Colorado, Kansas City and Cleveland (make-up games from rain), the Yanks lost a typical trap series to Seattle. Joe Girardi's group should be better prepared for the American League East counterpart Blue Jays. Toronto plays the next 10 games against AL East teams (three in New York, three vs. Tampa Bay and four vs. Baltimore).
Player to watch: CC Sabathia. Sabathia gets the start on Sunday. His velocity, as everyone knows, is down this season. But CC has figured a few things out and is better at locating his pitches because he has to, especially the fastball on the outside and the changeup anywhere. Sabathia still gives the Yanks plenty of innings and will face a free-swinging Blue Jay lineup which should help him. Sabathia needs a really good start to get him back in the right direction again, like his April 7 and 12 starts against Detroit and Baltimore where the big lefty through 15 innings, struck out 13 and earned two wins.
Pitching match-ups: Friday: Mark Buehrle (1-2, 6.19 ERA) vs. Hiroki Kuroda (5-2, 2.31 ERA). Saturday: Brandon Morrow (1-2, 4.69 ERA) vs. David Phelps (1-2, 4.33). Sunday: R.A. Dickey (3-5, 4.83 ERA) vs. CC Sabathia (4-3, 3.19 ERA).
Prediction: Yankees win two of three. New York has the pitching edge and the lineup edge. And even though Toronto is hot as of late, their defense is still bad and so is the bullpen. Don't expect two straight quality starts from Buehrle, Morrow or Dickey either, all of whom pitched well in their last outing. All three just aren't good enough right now for that.
By: Mike Lindsley, "Mid-Day with Mike," 1-4, Yankees pre/post game host on 104.5 The Team ESPN Radio. Follow him on Twitter @MikeLSports.
Filed Under: boston red sox, Brandon Morrow, cc sabathia, david phelps, hiroki kuroda, mark buehrle, R.A. Dickey, san francisco giants, seattle mariners, toronto blue jays
Categories: Around Albany


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Each one of the detailed rooms at the Hotel reflects the natural textures of the landscapes with sleek lines; providing a comfortable environment perfect to rest comfortably.
Hotel Château Viñasoro has Executive, Superior and Junior Suite rooms with exclusive details. We also have rooms adapted to people with reduced mobility by request. For a higher comfort, you may demand a king-size bed or two beds when you book the room.
Simple rooms with a warm and welcoming atmosphere, perfect to combine work and rest.
Comfortable and classic rooms, with everything necessary to provide rest and comfort.
These rooms, with subtlety and its own style, offer the best comfort. They are elegantly designed with contemporary furniture and warm colours.
Hotel Château Viñasoro, in Alcázar de San Juan, in the heart of la Mancha, has Executive, Superior and Junior Suite rooms with exclusive details.
We also have rooms adapted to people with reduced mobility by request. For a higher comfort, you may demand a king-size bed or two beds when you book the room.


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Celebrities Entertainment Carlos Santos: Top 10 Must-Know Facts About Comedian
Carlos Santos: Top 10 Must-Know Facts About Comedian
Carlos Santos (Comedian) was born on the 9th of April, 1981. He was born in 1980s, in Millennials Generation. His birth sign is Aries and his life path number is 5. Carlos's birth flower is Sweet Pea/Daisy and birthstone is Diamond. What does this all mean? Let's find out!
Discover all the facts that no one tells you about Carlos Santos below ↓
NAME: Carlos Santos
REAL NAME: Carlos Santos
NICKNAME: Carlos
PROFESSION: Comedian
BIRTHPLACE: Puerto Rico
Carlos Santos, best known for being a Comedian, was born in Puerto Rico on Thursday, April 9, 1981. Comedian, YouTube personality and video DJ who became the host of MTV Tr3s' hit show MiTRL after getting his start as a host for the music variety show LATV Live.
Family: He was born and raised in Puerto Rico with two older sisters. Carlos Santos father's name is under review and mother unknown at this time. We will continue to update details on Carlos Santos's family.
Dating: According to CelebsCouples, Carlos Santos is single .
Net Worth: Online estimates of Carlos Santos's net worth vary. It's easy to predict his income, but it's much harder to know how much he has spent over the years. CelebsMoney and NetWorthStatus does a good job of breaking most of it down.
2. Carlos Santos's zodiac sign is Aries
Carlos Santos zodiac sign is a Aries. Dates of Aries are March 21 - April 19. Those born under the Aries zodiac sign have an exciting and enthusiastic energy. They often seek new and challenging adventures that can push their limits. They are brave, direct, fearless, independent and have deep sense of justice. They love competition, in all its forms. Although, they can be aggressive, self-centered, pushy, inconsistent, bad-tempered, and selfish.
BORN IN THE YEAR OF THE: Rooster
RULING PLANET: Mars
3. He is currently 40 years old
The comedian has been alive for 14,892 days or 357,428 hours. There were precisely 505 full moons after his birth to this day.
BORN ON: Thursday
Carlos Santos was born on a Thursday. The 'thur' in Thursday is actually derived from the Norse god Thor. People born on Thursdays are generally a fun to be around, which means Thursday's babies get to be the life of the party.
Countdown to Carlos Santos's next birthday.
Carlos Santos will be turning 41.
4. On Carlos Santos's birthday
The world's population was 4,537,845,777 and there were an estimated 127,030,934 babies born throughout the world in 1981, Ronald Reagan (Republican) was the president of the United States, and the number one song on Billboard 100 was "Kiss On My List" by Daryl Hall John Oates.
1483 – Edward V (aged 12) succeeds his father Edward IV as king of England. He is never crowned, and disappears presumed murdered, after incarceration in the Tower of London with his younger brother Richard (the "Princes in the Tower").
1731 – British mariner Robert Jenkins' ear cut off by Spanish Guarde Costa in the Caribbean, later catalyst for war between Britain & Spain.
1768 – John Hancock refuses to allow two British customs agents to go below deck of his ship, considered by some to be the first act of physical resistance to British authority in the colonies.
5. Carlos Santos's height and weight
We're currently in process of confirming all details such as Carlos Santos's height, weight, and other stats. If there is any information missing, we will be updating this page soon. If you any have tips or corrections, please send them our way.
6. The Year of the Rooster
Carlos Santos was born in the Year of the Rooster. People with Chinese zodiac Rooster according to Chinese zodiac have many excellent characteristics, such as being honest, bright, communicative and ambitious. Most of them are born pretty or handsome, and prefer to dress up. Their strengths are being independent, capable, warm-hearted, self-respect, and quick minded. But they can also be impatient, critical, eccentric, narrow-minded, and selfish. Their lucky numbers are 5, 7, 8 and lucky colors are gold, brown, brownish yellow, yellow.
7. Carlos Santos's life path number is 5
Life Path Number 5 represent 'The Free Spirit'. Those who walk a Life Path with Number 5 have an uncanny ability to understand the deepest esoteric & metaphysical teachings. 5 turns the mystical into the norm. Its energy is that of Experience. The values are adventure, movement, change. The challenges are to find some kind of daily structure that works for you.
Carlos Santos was born in the middle of Millennials Generation.
9. Carlos Santos's birthstone is Diamond
Diamond is a symbol of everlasting love and once was thought to bring courage. The diamond is the symbol of purity, innocence, eternity and courage.
10. Carlos Santos's birth flower is Sweet Pea/Daisy
Daisy symbolizes purity, true love and innocence.


What makes a healthy lunch?
Pass the school lunchbox test with our easy, healthy food suggestions.
All out of ideas for a healthy school lunch?
Eating healthy food helps children concentrate and learn, so it's really important for your child to have a healthy lunchbox at school.
The best lunch is one that's nutritious, quick to make, and fun and easy to eat. Encouraging your children to be involved in choosing foods and preparing their lunch increases the odds it will all be eaten – and enjoyed!
A carbohydrate-based food is a good starting point for a lunch to fill hungry tummies. This can be bread, pasta, rice, potatoes (not chips!) or couscous, for example.
Sandwiches are often the lunchbox staple, but can get boring day after day. Keep kids interested by using a variety of breads, including wholemeal, white, rye, rolls, wraps, pita, bagels, focaccia and rice cakes.
Lean meat, tinned tuna, egg, tofu and baked beans are good high-protein foods for filling sandwiches, or for adding to food like pasta or rice salad. Importantly, most provide iron as well.
Nuts and peanut butter are also good protein sources, but check first if your school has a nut-free policy to protect children with severe allergies.
Protein-rich dairy foods like yoghurt and cheese are also good sources of calcium, which is essential for growing bodies – especially for strong bones.
For plenty of vitamins, minerals and dietary fibre, try to include at least a serve each of fruit and veg in every lunchbox.
Kids might find vegetables more interesting served as sticks with dip, mixed together with pasta, or as topping for a mini pizza.
Pack fruit and veg that are manageable and easy to eat: fruit salad, mandarins or pre-peeled oranges, seedless grapes, cherry tomatoes or snow peas, for example.
Don't forget a drink! Active bodies need plenty of fluid to keep them well hydrated, and water is the best choice, although milk – either cow's or soy with added calcium – is good too.
Drinks can linger in kids' mouths, so sugary ones may increase the risk of tooth decay; 100% fruit juice can be diluted. Drinks with added sugar that don't provide the same nutritional goodies as fruit juice – sweetened juice, "fruit drinks", cordial and fizzy drinks, for example – are best left out altogether.
Hygiene. Make sure your hands, chopping board and utensils are clean and dry before preparing food.
Keep the food cold. Use an insulated lunchbox and/or put a freezer pack in with the food to keep it cool. Alternatively, include a frozen drink bottle in the lunchbox – it should defrost by lunchtime. If the school provides a refrigerator, make sure your child uses it.
Preparation. Save time and keep food cool by freezing sandwiches the night before (or even prepare and freeze sandwiches for a week in advance). Foods suitable for freezing include bread, cooked meat, cheese, peanut butter, baked beans, mashed eggs and Vegemite. Yoghurt and fruit, like grapes and banana or citrus segments, can be frozen too.
Pre-packaged snacks for kids' lunchboxes can be convenient, but not all are healthy enough to include regularly. Our reviews of these snack foods have consistently found that very few meet our four nutritional criteria of acceptable energy, saturated fat, sugar and sodium levels.