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On-Screen
This Week's New Reads
GIFnotes
Pick Your Poison
Cooking the Books
True Crime Thursday
Perp Derp
Powers 1.02: "Like a Power"
By Hector DeJean
So who is up to no good on Powers? Is it Calista (Olesya Rulin), the runaway who wants to be part of the super-powered community? Is it Zora (Logan Browning), the attractive "Powers Kid" hoping to turn her abilities into celebrity cred? Is it Krispin (Max Fowler), the son of Walker's (Sharlto Copley) dead partner?…
Powers 1.01: "Pilot"
Debuting on Sony's Playstation Network as their first original scripted show, Powers is an odd bird; a lot of labels could be applied to it, but none of them really fit. It was based, loosely, on a comic book series, but it's not a comic book show like The Flash or Supergirl; its protagonists are…
Celebrating 75 Years of Captain America
By Dave Richards
I don't remember how young I was when I discovered reruns of the 1966 Marvel animation show on a local syndication network, but it had to be the very early '80s. What I remember most was Captain America's cheesy and incredibly catchy theme, which featured the lyrical refrain: "When Captain America throws his mighty shield."…
Heroes Reborn 1.13: "Project Reborn"
By Corrina Lawson
Heroes traveling through time to save the world from destruction! Go! No, not the premiere of DC's Legends of Tomorrow. I'm talking about the finale of the Heroes Reborn miniseries, which aired in the same time slot as DC's newest superhero show. There has been a lot of hype about…
Suicide Squad: New Trailer Released
By Adam Wagner
Not to be outdone by the titans of industry that Marvel Studios has become, DC Comics is set to release two blockbuster films this year, Batman v Superman: Dawn of Justice and Suicide Squad. While I'll reserve judgment for the Bahstan Ben Affleck Batman for when it actually comes out, the star-studded antihero/supervillain movie, Suicide…
Heroes Reborn 1.12: "Company Woman"
All season, Erica Kravid (Rya Kihlstedt) has been a mustache-twirling, one-dimensional villain convinced that her plan to rescue a chosen few from the End of the World™ is morally justifiable. I've gotten used to that. But instead of using the show's penultimate episode to show how our heroes gather to save the world, Erica's backstory…
Heroes Reborn 1.11: "Send in the Clones"
Two episodes left in this mini-series, and we still don't have the twins united. That's a good indication of everything wrong with this show. It had an intriguing start that centered around Noah Bennett (Jack Coleman) and his twin grandchildren, with several characters meandering in and out, but the two-part time travel episode where Hiro…
A Batman Christmas: The Yuletide Hero Gotham Deserves
The Holidays are supposed to be a time of peace on Earth and goodwill towards everyone, but as popular culture has shown us, some people view them as a season of sinister opportunity. So, some of the most fun and enjoyable Christmas tales are the ones where we get thrilling confrontations between valiant heroes and…
Jessica Jones Review: Season 1, Episodes 1-4
Hello! Welcome to my recaps of Marvel's Jessica Jones. I'm Dave Richards and I'll be your sort of guide as we look at the latest offering from Marvel Studios and Netflix—a series adapted and inspired by Brian Michael Bendis and Michael Gaydos's Marvel Comic series Alias, which ran from 2001-2004 and examined what happens when…
Heroes Reborn 1.10: "11:53 to Odessa"
With 3 episodes left in this "event" miniseries, we break for the holiday season being no closer to saving the world than when we began. Tommy is still without his memory or real allies, and Malina is stuck with our mass-murdering psycho, Luke. Okay, he's reformed now, but I'm with Noah—no reason to trust this…
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We have recently merged with our son's company PHILLIP BANKS DESIGN AND BUILD which has enabled us to expand our services to now also include asbestos surveying and testing to comply with Health and Safety and Building Regulation Law.
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The Sizzelle Hairline Challenge is going strong and there's one more month left. I hope everyone is progressing well.
It is said that confession is good for the soul. I have a confession to make . . . my hairline isn't doing too well. I kept up with the challenge for the most part but I think the braids I recently got did not help me at all. Right before I got them, a friend warned me that this may happen. However, I was stubborn and wanted to try it again. My edges aren't as bad as the terrible setback that I had last year but they are a bit scanty. Don't worry. I have evidence of my crime. 🙁 Here's how I did with the challenge this month.
Moisture: Moisturize and seal at least once per day and ensure that edges and nape have been properly moisturized. Deep condition at least once a week. FAIL! Since my hair was in Senegalese Twists, I did not moisturize everyday but I did it at least 3 times a week. I did not deep condition when I washed my hair.
Reduce manipulation and tension: Use styles that reduce tension at these sensitive areas. FAIL! Towards the end of June, I got Senegalese twists done and had them in for most of July. The braids did not pull at my hairline during the install. However, my hairline is not faring so well.
Castor oil: Use Jamaican Black castor oil for scalp massages at least 4 times a week, focusing on edges and nape. I used JBCO about 3 times a week so this could be a partial success.
Exercise and diet: Do some form of exercise at least 3 times a week. Increase my intake of fruits and vegetables. Take my multivitamins daily. SUCCESS! As I mentioned in my last Hair Musings post, I increased the amount I worked out to 3 times per week. My workouts involve running (Couch 2 5K) and Jillian Michaels 30 Day Shred. I also increased my fruit and vegetable intake by preparing smoothies. I started this about 2 weeks ago. I never really liked smoothies before but these smoothies are tasty. I usually use more fruit than vegetables but I have to start somewhere. 🙂 I also kept up with my vitamins and started taking biotin.
Here are some comparison pictures of my hairline in May versus July. I'm not sure if the pictures capture the difference but I can definitely feel it. My only consolation is that my nape has improved. I've noticed some length retention since I started my edge and nape challenge earlier this year.
How do you protect your hairline?
Hey , it is not that bad na. You too lay off the braids. Your nape hair is really doing great though.


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News U18
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Researchers of CIBER-BBN and NANBIOSIS-ICTS (U6 Biomaterial Processing and Nanostructuring Unit at ICMAB-CSIC and U18 Nanotoxicology Unit at Hospital de la Santa Creu i Sant Pau have developed a new nanocarrier for bio-imaging and drug-delivery applications
The new nanovesicle formulation is based on the quatsome architecture – which stands out due to the high colloidal stability and homogeneity in size – and has now been shown to be suitable for in vivo dosing.
Quatsomes are new non-liposomal lipid-based nanovesicles that have been developed by Nanomol group in recent years, and have been shown to be highly homogeneous and stable in different media for years. This colloidal stability involves important advantages for the development of pharmaceutical formulations and for guaranteeing the final product quality. Quatsomes are a promising nanocarrier for bio-imaging and drug-delivery applications, suitable for the encapsulation of both hydrophilic and hydrophobic molecules, easily functionalized with elements that favor the directionality towards therapeutic targets.
To facilitate their use in in vivo applications, Nanomol group has now developed a new Quatsome formulation, composed of cholesterol and myristalkonium chloride (MKC), the C14 homolog of benzalkonium chloride (BAK), the latter being extensively used as antimicrobial preservative in many ophthalmic and parenteral formulations on the EU and USA market. These novel MKC-Quatsomes have been synthesized in different media that are suitable for parenteral administration, in which they showed to be stable for at least 18 months. Moreover, vesicles remained stable in human serum for at least 24 hours.
In collaboration with the Oncogenesis and Antitumour Drug group of the Biomedical Research Institute of the Hospital de la Santa Creu i Sant Pau, these MKC-Quatsomes were tested in live mice bearing xenografted colorectal tumors. After intravenous injection of fluorescently labelled MKC-Quatsomes, biodistribution assays showed nanovesicle accumulation in tumors, liver, spleen, and kidneys, but not in any other organ. Importantly, MKC-Quatsomes were well-tolerated at the administered doses, and no histological alterations or toxicity was found in any of these organs. These new results suggest the applicability of quatsomes in therapeutic approaches that require systemic delivery.
NANOMOL group, Coordinator of NANBIOSIS U6 at ICMAB-CSIC and the Oncogenesis and Antitumor Drug group, coordinator NANBIOSIS U18 at Biomedical Research Institute (Hospital de la Santa Creu i Sant Pau) are members of Biomedical Research Networking center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) and have a wide expertise and recognized excellence in the synthesis, processing and study of molecular and polymeric materials and the study of their biomedical properties. NANOMOL is also a member of the technology transfer network TECNIO. '
Article of reference:
MKC-Quatsomes. A stable nanovesicle platform for bio-imaging and drug-delivery applications co-authored by Guillem Vargas-Nadal et al., Nanomedicine: Nanotechnology, Biology and Medicine, 24 (2020) 102136. https://doi.org/10.1016/j.nano.2019.102136
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A step forward for the design of multifunctional protein nanomaterials for cancer therapies
Researchers of NANBIOSIS Unit 1 and NANBIOSIS Unit 18, led by Prof Antoni Villaverde have published the article at the prestigious scintific magazine titled Collaborative membrane activity and receptor-dependent tumor cell targeting for precise nanoparticle delivery in CXCR4+ colorectal cancer
The researchers have shown that the combination of cell-penetrating and tumor cell-targeting peptides dramatically enhances precise tumor accumulation of protein-only nanoparticles intended for selective drug delivery, in mouse models of human colorectal cancer. This fact is a step forward for the rational design of multifunctional protein nanomaterials for improved cancer therapies.
Protein production has been partially performed by the ICTS NANBIOSIS U1, Protein Production Platform and the nanoparticle size analysis by the U6 of NANBIOSIS Biomaterial Processing and Nanostructuring Unit. Biodistribution studies were performed by the U18 of the ICTS NANBIOSIS, Nanotoxicology Unit.
Rita Sala, LauraSánchez-García, Naroa Serna, María Virtudes Céspedes, Isolda Casanova, Mònica Roldán, Alejandro Sánchez Chardig, Ugutz Unzueta, Esther Vázquez, Ramón Mangues, Antonio Villaverde. Collaborative membrane activity and receptor-dependent tumor cell targeting for precise nanoparticle delivery in CXCR4+ colorectal cancer. Acta Biomaterialia, 99, Pages 426-432. 2019,
Why the poor biodistribution so far reached by tumor-targeted medicines?
Cell-selective targeting is expected to enhance effectiveness and minimize side effects of cytotoxic agents. Functionalization of drugs or drug nanoconjugates with specific cell ligands allows receptor-mediated selective cell delivery. However, it is unclear whether the incorporation of an efficient ligand into a drug vehicle is sufficient to ensure proper biodistribution upon systemic administration, and also at which extent biophysical properties of the vehicle may contribute to the accumulation in target tissues during active targeting. To approach this issue, structural robustness of self-assembling, protein-only nanoparticles targeted to the tumoral marker CXCR4 is compromised by reducing the number of histidine residues (from six to five) in a histidine-based architectonic tag. Thus, the structure of the resulting nanoparticles, but not of building blocks, is weakened. Upon intravenous injection in animal models of human CXCR4+ colorectal cancer, the administered material loses the ability to accumulate in tumor tissue, where it is only transiently found. It instead deposits in kidney and liver. Therefore, precise cell-targeted delivery requires not only the incorporation of a proper ligand that promotes receptor-mediated internalization, but also, unexpectedly, its maintenance of a stable multimeric nanostructure that ensures high ligand exposure and long residence time in tumor tissue.
The concept presented by the authors of the present research might represent a convincing explanation of the poor biodistribution so far reached by tumor-targeted medicines, including antibody-drug conjugates. In addition to this, they offer a potential developmental roadmap for the improvement of these drugs, of high intrinsic therapeutic potential, to reach satisfactory efficiencies in the clinical context.
Hèctor López-Laguna, Rita Sala, Julieta M. Sánchez, Patricia Álamo, Ugutz Unzueta, Alejandro Sánchez-Chardi, Naroa Serna, Laura Sánchez-García, Eric Voltà-Durán, Ramón Mangues, Antonio Villaverde and Esther Vázquez. Nanostructure Empowers Active Tumor Targeting in Ligand-Based Molecular Delivery. Part. Part. Syst. Charact. 2019.
DOI: 10.1002/ppsc.201900304
Artificial inclusion bodies for controlled drug release
Researchers from NANBIOSIS-CIBER-BBN have developed a new type of protein biomaterial that allows a continuous release over time of therapeutic proteins when administered subcutaneously in laboratory animals.
These results are the result of the stable scientific collaboration between the researchers of NANBIOSIS Units 1 Protein Production Platform (PPP)and 18 Nanotoxicology Unit, led by Toni Villaverde and Ramón Mangues at the Institute of Biotechnology and Biomedicine of the Autonomous University of Barcelona (IBB-UAB) and the Institut About the Hospital de Sant Pau and has had the participation of the Institute of Biological and Technological Research of the National University of Córdoba-CONICET, in Argentina
"These structures, of a few micrometers in diameter, contain functional proteins that are released in a manner similar to the release of human hormones in the endocrine system," says Antonio Villaverde. Ramón Mangues explains that "the new biomaterial mimics a common bacterial product in biotechnological processes called 'inclusion bodies', of pharmacological interest, which in this artificial version offers a wide range of therapeutic possibilities in the field of oncology and in any other field clinic that requires sustained release over time." Researchers have used common enzymes in biotechnology as a model and a nanostructured bacterial toxin that targets metastatic cells of human colorectal cancer, which has been tested in animal models. "In this way we have managed to generate both immobilized catalysts and a new long-acting anti-tumor drug," said the researchers responsible for the research.
The developed artificial protein granules, which had previously been proposed as 'nanopills' (tablets of therapeutic material on a nanoscopic scale), mimic bacterial inclusion bodies and offer enormous clinical potential in the field of vaccinology and as release systems Drug controlled.
"We have seen that natural inclusion bodies, administered as medicines, can generate unwanted immune responses due to the inevitable contamination with bacterial materials," the researchers comment. However, in the new work, the development of artificial inclusion bodies with secretion capacity "avoids many of the regulatory problems associated with the potential development of bacterial nanopills, and offers a cross platform for obtaining functional components in cosmetics and in clinic" they add.
This work points to artificial inclusion bodies as a new exploitable category of biomaterials for biotechnological applications with a more simple manufacturing and clinical applications.
Julieta M. Sánchez, Hèctor López ‐ Laguna, Patricia Álamo, Naroa Serna, Alejandro Sánchez ‐ Chardi, Verónica Nolan, Olivia Cano ‐ Garrido, Isolda Casanova, Ugutz Unzueta, Esther Vazquez, Ramon Mangues, Antonio Villaverde Artificial Inclusion Bodies for Clinical Development
https: //doi.org/10.1002/advs.201902420
A new method simple and efficient for the preparation of Oligonucleotide-protein conjugates
Oligonucleotide-protein conjugates have important applications in biomedicine. Four units of NANBIOSIS have collaborated to come across with more simple and efficient methods for the preparation of these conjugates.
In the publication of the research results, a new method is described in which a bifunctional linker is attached to thiol-oligonucleotide to generate a reactive intermediate that is used to link to the protein. Having similar conjugation efficacy compared with the classical method in which the bifunctional linker is attached first to the protein, this new approach produces significantly more active conjugates with higher batch to batch reproducibility. In a second approach, direct conjugation is proposed using oligonucleotides carrying carboxyl groups. These methodologies have been applied to prepare nanoconjugates of an engineered nanoparticle protein carrying a T22 peptide with affinity for the CXCR4 chemokine receptor and oligomers of the antiproliferative nucleotide 2′-deoxy-5-fluorouridine in a very efficient way. The protocols have potential uses for the functionalization of proteins, amino-containing polymers or amino-lipids in order to produce complex therapeutic nucleic acid delivery systems.
Protein production and DLS have been partially performed by the NANBIOSIS Units of CIBER-BBN U1 Protein Production Platform (PPP) at IBB-UAB and U6 Biomaterial Processing and Nanostructuring Unit of CIBER-BBN and ICMAB-CSIC. Also, NANBIOSIS U18 of Nanotoxicology at the Hospital de la Santa Creu i Sant Pau has been used and the team of researcher counted with the NANBIOSIS expertise of U29 Oligonucleotide Synthesis Platform (OSP) at IQAC-CSIC
Avino, Anna; Unzueta, Ugutz; Cespedes, Maria Virtudes; Casanova, Isolda; Vazquez, Esther; Villaverde, Antonio; Mangues, Ramon; Eritja, Ramon. Efficient bioactive oligonucleotide-protein conjugation for cell-targeted cancer therapy. CHEMISTRYOPEN 8, 3 (382-387), 2019
https://doi.org/10.1002/open.201900038
A CXCR4-targeted nanocarrier achieves highly selective tumor uptake in diffuse large B-cell lymphoma mouse models
Researchers of NANBIOSIS Unit 1 and NANBIOSIS Unit 18, led by Ramón Mangues, have published the article titled CXCR4-targeted nanocarrier achieves highly selective tumor uptake in diffuse large B-cell lymphoma mouse models .
One-third of diffuse large B-cell lymphoma patients are refractory to initial treatment or relapse after rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone chemotherapy. In these patients, CXCR4 overexpression (CXCR4+) associates with lower overall and disease-free survival. Nanomedicine pursues active targeting to selectively deliver antitumor agents to cancer cells, a novel approach that promises to revolutionize therapy by dramatically increasing drug concentration in target tumor cells. In the study carried out at NANBIOSIS ICTS the resarchers intravenously administered a liganded protein nanocarrier (T22-GFP-H6) targeting CXCR4+ lymphoma cells in mouse models to assess its selectivity as a nanocarrier, by measuring its tissue biodistribution in cancer and normal cells. No previous protein-based nanocarrier has been described to specifically target lymphoma cells. T22-GFP-H6 achieved a highly selective tumor uptake in a CXCR4+ lymphoma subcutaneous model, as detected by fluorescent emission. We demonstrated that tumor uptake was CXCR4- dependent because pretreatment with AMD3100, a CXCR4 antagonist, significantly reduced tumor uptake. Moreover, in contrast to CXCR4+ subcutaneous models, CXCR4- tumors did not accumulate the nanocarrier. Most importantly, after intravenous injection in a disseminated model, the nanocarrier accumulated and internalized in all clinically relevant organs affected by lymphoma cells, with negligible distribution to unaffected tissues. Finally, the researchers obtained antitumor effect without toxicity in a CXCR4+ lymphoma model by T22-DITOX-H6 administration, a nanoparticle incorporating a toxin with the same structure as the nanocarrier. Hence, the use of T22-GFP-H6 nanocarrier could be a good strategy to load and deliver drugs or toxins to treat specifically CXCR4-mediated refractory or relapsed diffuse large B-cell lymphoma without systemic toxicity.
The bioluminescent follow-up of cancer cells and nanoparticle biodistribution and toxicity studies has been performed in the ICTS NANBIOSIS, using its unit 18 of Nanotechnology of CIBER-BBN and Hospital Sant Pau The Protein production has been partially performed by the Protein Production Platform (PPP) Unit 1 of ICTS NANBIOSIS of CIBER-BBN and IBB-UAB.
Aïda Falgàs, Victor Pallarès, Ugutz Unzueta, María Virtudes Céspedes, Irene Arroyo-Solera, María José Moreno, Alberto Gallardo, María Antonia Mangues, Jorge Sierra, Antonio Villaverde, Esther Vázquez, Ramon Mangues, and Isolda Casanova. A CXCR4-targeted nanocarrier achieves highly selective tumor uptake in diffuse large B-cell lymphoma mouse models. Haematologica 2019
doi:10.3324/haematol.2018.211490
Non-Hodgkin lymphoma treatment with protein nanoparticles
A study result of collaboration between researchers of two NANBIOSIS units managed to produce a potent antitumor effect in an animal model with non-Hodgkin lymphoma
A non-Hodgkin's lymphoma, NHL is a cancer that starts in white blood cells called lymphocytes, which are part of the body's immune system.
Lymphoma. NHL is a term that's used for many different types of lymphoma that share some characteristics. The most prevalent type of non-Hodgkin lymphoma is called diffuse large B-cell lymphoma (LDCGB). Although there are treatments for this pathology, there are non-responders.
This nanoparticle can be developed as a nanopharmaceutical, in order to introduce a new treatment, which could be used in 40 percent of patients with non-Hodgkin lymphoma who do not respond to current therapy, and avoiding the adverse effects associated with conventional treatment.
The research conducted by the CIBER-BBN at the Hospital de Sant Pau, led by Ramón Mangues (Nanbiosis U18 Nanotoxicology Unit) and the Autonomous University of Barcelona, led by Antoni Villaverde Nanbiosis U1 Protein Production Platform (PPP) has demonstrated the high selectivity of a protein-based nanomedicine and created by the researchers themselves, for the targeted delivery of a toxin in the tumor cells to induce their selective death. The objective is that these nanoparticles can be developed as a nanopharmaceutical, which could be used in 40 percent of patients with non-Hodgkin lymphoma who do not respond to current therapy, avoiding the adverse effects associated with conventional treatment
This selective effect of the nanopharmaceutical is due to the specific interaction between a targeting peptide that contains the protein nanoparticle that carries the toxin and the CXCR4 cell receptor that is highly overexpressed in lymphoma cells. This is the first time that the uptake of protein nanoparticles in different organs of a hematological neoplasm is quantified.
This observation has shown that 86 percent of the administered dose accumulates in cancer cells, a substantial improvement compared to other non-protein nanoparticles or other drug targeting systems such as drug-antibody conjugates, which only reach 1 percent of the dose in the tumor.
As Ramón Mangues, Scientific Director of Nanbiosis U18 Nanotoxicology Unit, explains, "the new protein nanoparticle contains a ligand that identifies a CXCR4 receptor on the surface of cancer cells in which it enters selectively, reaching a very high uptake of the tumor and very low in the rest of the body, which greatly exceeds the tumor uptake of drugs used for this type of lymphoma."
The bioluminescent follow-up of cancer cells and nanoparticle biodistribution and toxicity studies has been performed in the ICTS NANBIOSIS Nanotoxicology Unit Protein production has been partially performed by the ICTS "NANBIOSIS", more specifically by the Unit of Protein Production Platform.
The first Nanocomposite that slows the spread of colon cancer
The creation of a nanodrug capable of blocking the spread of the disease, which is known as metastasis, has been highlighted by Guia Medica, as a heavy blow struck against to colon cancer, the malignant tumor with the highest incidence in our country, a process that affects 40% of the million cases of this type of cancer that are diagnosed every year in the world, and that represents the main cause of death.
The research, jointly carried out by scientists from the IIB Sant Pau, Sant Pau Hospital, the UAB, CSIC and CIBER-BBN, led by Esther Vázquez and Antonio Villaverde, Strategy Director of NANBIOSIS U1. Protein Production Platform (PPP) in the IBB-UAB and Ramon Mangues, Scientific Director of NANBIOSIS U18. Nanotoxicology Unit in the Sant Pau Hospital, were published in the scientific journal EMBO Molecular Medicine ando pen a new way to prevent metastasis in colorectal cancer in humans, using a nanomedicine that selectively eliminates metastatic stem cells.
NANBIOSIS Unit 18 of Nanotoxicology has been involved in the study of the biodistribution and the antimetastatic effect and on normal organs of the nanoconjugate administered and the unit and Unit 1 PPP, has contributed to the production of the protein part of the nanoconjugate.
The new drug works like a drone that identifies a receptor (CXCR4) in metastatic stem cells. Once localized, it administers the drug and destroys it, blocking the metastasis, according to research sources. By acting only on metastatic tumor cells, the new nanodrug avoids the general toxicity associated with the usual treatments against cancer and preserves healthy cells. Although up to now it has been successfully tested in animals suffering from colorectal cancer, the researchers who have carried out the trial believe that it could be used in 20 types of additional tumors, which also express CXCR4, as in prostate, breast, ovarian and other tumors.
NANBIOSIS Scientific Women in the International Day of Women and Girls in Science
Today February 11 is the International Day of Women and Girls in Science, a day to raise awareness of the gender gap in science and technology.
According to the United Nations, while yet women and girls continue to be excluded from participating fully in science, science and gender equality are vital to achieve the internationally agreed development goals, including the 2030 Agenda for Sustainable Development. Thus, in recent years, the international community has made a great effort to inspire and promote the participation of women and girls in science.
NANBIOSIS wants to acknowledge the efforts made by scientific women who struggle every day to contribute their bit to Science and highlight their essential role in nowadays research. Especially we want to recognize the work of scientists women involved in our units, whatever is the nature of their contribution: technical, scientific development, management, coordination, direction, etc; just to mention some examples:
Neus Ferrer in the Scientific Direction of Unit 1 Protein Production Platform (PPP)
Pilar Marco and Nuria Pascual in the Management and Scientific Coordination of U2 Custom Antibody Service (CAbS)
Miriam Royo in the Scientific Direction of U3 Synthesis of Peptides Unit
Laura Lechuga and M.Carmen Estevez in the Direction and Scientific Coordination of U4 Biodeposition and Biodetection Unit
Nora Ventosa and Nathaly Segovia in the Scientific Direction and Technical Coordination of U6 Biomaterial Processing and Nanostructuring Unit
Isabel Oliveira and Teresa Galán in the Coordination of U7 Nanotecnology Unit
Rosa Villa and Gemma Gabriel in the Management and Scientific Coordination of U8 Micro – Nano Technology Unit
Gema Martínez in the Scientific Coordination of U9 Synthesis of Nanoparticles Unit
Fany Peña in the Scientific Coordination of U13 Tissue & Scaffold Characterization Unit
Mª Luisa González Martín in the of Direction and Scientific Coordination of U16 Tissue & Scaffold Characterization Unit
Gemma Pascual and Isabel Trabado in the Coordination of the U17 Confocal Microscopy Service
Mª Virtudes Céspedes in the Scientific Coordination of U18 Nanotoxicology Unit
Beatriz Moreno in the Scientific Direction of Unit 19 Clinical tests lab
Ibane Abásolo in the Scientific Coordination of Unit 20 In Vivo Experimental Platformt
Verónica Crisóstomo in the Scientific Direction of Unit 24 Medical Imaging
Ana Paula Candiota in the Scientific Coordination of Unit 25 Biomedical Applications I
Maria Luisa García in the Scientific Direction of U28 NanoImaging Unit from Bionand, recently incorporated to NANBIOSIS
Thanks to all of you and your teams!
NANBIOSIS Against Cancer
The World Health Organization, the International Cancer Research Center (IARC) and the International Union Against Cancer (UICC) celebrate February 4 of each year as World Cancer Day
Every year, 14 million new cases of cancer are diagnosed worldwide and the disease causes 8.2 million deaths.
Thanks to scientific research, great advances have been made in the fight against cancer. Through surgery, chemotherapy or radio therapy and, in the last 20 years, through immunotherapy, hormonal treatment or cell therapies, tools have been obtained to improve early diagnosis and treatments, increasing cancer survival by 20%.
The only way to understand cancer and, someday, eradicate it or eliminate the suffering and death due to this disease, is RESEARCH
NANBIOSIS as an ICTS (Singular Scientific and Technical Infrastructures) for biomedical research plays a very important role in the fight against cancer. Some examples are bellow:
Thanks to a coordinated action between units U1 of Protein Production Platform (PPP), U18 of Nanotoxicology and U29 of Nucleic Acid Synthesis, NANBIOSIS is developing nanopharmaceuticals with a high degree of efficacy for the treatment of metastases in colon cancer, by using of proteins with high specificity of binding to metastatic cells and a high degree of permanence in the blood flow, loaded with anti-cancer drugs that are selectively released inside the tumor cells that are going to form the metastases. Through the public financing of a NEOTEC project and a RETOS-COLABORACION and the company NANOLIGENT SL, the first antimetastatic drug on the market will be developed.
The Protein Production Platform-PPP collaborates with research projects whose objective is the development of new cancer therapies based on recombinant modular proteins with the ability to self-assemble. These multimeric complexes have shown, in animal models, a high stability in serum and an improved biodistribution compared to that observed with drugs for clinical use. These principles have been valued in different types of cancer, including colorectal cancer and breast cancer. The modular design of these constructions allows the incorporation or substitution of direct peptides and therefore they are presented as a transversal tool for more effective treatments against cancer. In addition, the PPP has served the Vall d'Hebron Institute of Oncology (VHIO) of Barcelona, the Josep Vilanueva group (CIBERONC) in the field of biomarker study and new targets associated with triple negative breast cancer (TNBC).
Unit 6 of NANBIOSIS Biomaterial Processing and Nanostructuring Unit is working on a project in collaboration with VHIR, financed by the Spanish Goverment and CIBER-BBN, for the development of a new nanomedicine for the treatment of high-risk neuroblastoma, one of the most frequent childhood cancers.
Unit 6 is also working on the project Artificial Lymph Nodes for Cancer ImmunoTherapy (ALYCIA) A project born of a initiative of CIBER-BBN/ CIBERONC to enhance scientific interdisciplinary collaborations between research groups working on oncology and nanomedicine. Researchers of unit 6 will develop Artificial Lymph Nodes (ALN) based on dynamic 3D scaffolds able to promote efficient ex vivo lymphatic cell expansion of relevant phenotypes. Such ALN represent a new approach to lymphocyte expansion, which not only includes artificial Antigen Presenting Cells in suspension like the state-of-the-art expansion techniques, but also mimics the function of the LN ex vivo.
One of the singular capabilities of the U25 of NANBIOSIS NMR: Biomedical Applications I is the acquisition of high quality, high resolution preclinical magnetic resonance imaging/spectroscopy/spectroscopic imaging data. This allows performing leading-edge studies in preclinical cancer models such as noninvasive therapy response follow-up in murine brain tumours, revealing new response biomarkers with translational potential for brain cancer patients.
NANBIOSIS U4 Biodeposition and Biodetection Unit is currently developing the national project PREDICT Point-of-care Nanoplasmonic Platforms for Novel High-Value Diagnostics and Therapy Follow-Up , which works in the early detection of lung cancer. PREDICT project will use the Unit 4 of Nanbiosis for the multiplexed biofunctionalization of the biosensor chips and their methodology optimisation.
Finally, Unit 20 of NANBIOSIS In Vivo Experimental Platform at VHIR, is the most implicated of the CIBER units on projects in the field of cancer, just to name some of them: H2020-NoCanTher: magnetic nanoparticles against pancreatic cancer through the use of hyperthermia combined with conventional treatment. H2020-Target-4-Cancer: nanotherapy based on polymeric micelles directed against specific receptors of tumor stem cells in colorectal cancer. H2020-DiamStar: nanodiamonds directed against leukemia for the potentiation of chemotherapy. FET-OPEN EvoNano: in silico and tumor-tumor models for the prediction of PK / PD and tumor efficacy of antitumor nanomedicines against tumor stem cells. FIS-ISCIII: polymeric micelles for siRNA and combined therapy against breast cancer tumor stem cells. CarboXigel: hydrogels for the sustained release of chemotherapeutic drugs against the metastatic spread of ovarian cancer. MelanoMir: nanomedicine applied to skin cancer, melanoma, beside other projects promoted by CIBER-BBN.
Accio arrhythmias assisted reproduction biofilm biomarkers biomedicine cancer ciber CIBER-BBN colorectal cancer CSIC Cutting-Edge Biomedical Solutions CXCR4 diabetes DRIVE PROJECT drug delivery EATRIS ESNAM Esther Pueyo European Reginal Development Funds Fabry disease FEDER Gene therapy graphene I3A ICMAB-CSIC icts Jaume Veciana JUMISC Materplat microfluidics mineco NANBIOSIS Nanobiosensors NANOLIGENT NANOMEDICINE NANOMOL Nanoparticles nanotechnology regenerative medicine Simó Schwartz Smart4Fabry training transplant pancreatic cells TYPE 2 DIABETES

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A palotás ünnepélyes tartású, lassú nemesi tánc, a 19. századi társastánc színpadi változata. Magyarországon hagyományos megnyitó tánc lett a bálokon.

Nevének eredete
A palotást eleinte főleg királyi és fejedelmi udvarokban táncolták. Elnevezését is a várak, kastélyok dísztermeiről (palota) nyerte.

Története
A magyar táncok kiforrásának ideje a 16. századra tehető. Köztük a palotásnak, mint táncnak említése először a 19. század elejétől fordult elő (Sándor István, 1801), de a 18. és 19. században élte fénykorát. Ünnepélyes tartású, derűs, lovagias hangulatú társastánc volt. Kialakulásához a kor új hangszerei, új zenéje és új szelleme ösztönözte arra a magyar nemességet, hogy kialakítsák saját előkelő táncukat, melyhez nagyban hozzájárult Rózsavölgyi Márk (1789-1848) magyar zeneszerző tevékenysége is. A Palotás részben a verbunkoson és a friss pároson alapszik, de érvényesül benne a férfias magyar virtus is, mely  előkelő, kifinomult tánccá fejlődött az Andalgóval. Időközben a színpadi zene is befogadta a Palotást Erkel Ferenc Hunyadi László című operájában, valamint Kodály Zoltán Háry János című daljátékán keresztül.

A 19. század második felében a  táncmesterek - köztük például Tóth Samu, Kinszky Károly is - több báli palotást is alkottak. A falusi tánciskolák vizsgabáljaira vagy a vidéki táncmesterek bálnyitóikra vagy bemutatóikra számos sematikus palotás változatot állítottak össze, mint például a sétapalotás, vagy a díszpalotás, de a Nyugat-Dunántúl egyes vidékein, köztük az Őrségben a páros lassú csárdást is gyakran nevezték palotásnak.

Források
 Magyar Néprajzi Lexikon
 Magyar Helikon Társaság

Hivatkozások
 YouTube: Erkel Ferenc: Hunyadi László

Magyar néptánc
Magyar néprajz

redpajama_set_name: RedPajamaWikipedia


text:
package main

import (
	"context"

	apigeeregistry "cloud.google.com/go/apigeeregistry/apiv1"

	apigeeregistrypb "google.golang.org/genproto/googleapis/cloud/apigeeregistry/v1"
)

func main() {
	ctx := context.Background()
	// This snippet has been automatically generated and should be regarded as a code template only.
	// It will require modifications to work:
	// - It may require correct/in-range values for request initialization.
	// - It may require specifying regional endpoints when creating the service client as shown in:
	//   https://pkg.go.dev/cloud.google.com/go#hdr-Client_Options
	c, err := apigeeregistry.NewProvisioningClient(ctx)
	if err != nil {
		// TODO: Handle error.
	}
	defer c.Close()

	req := &apigeeregistrypb.CreateInstanceRequest{
		// TODO: Fill request struct fields.
		// See https://pkg.go.dev/google.golang.org/genproto/googleapis/cloud/apigeeregistry/v1#CreateInstanceRequest.
	}
	op, err := c.CreateInstance(ctx, req)
	if err != nil {
		// TODO: Handle error.
	}

	resp, err := op.Wait(ctx)
	if err != nil {
		// TODO: Handle error.
	}
	// TODO: Use resp.
	_ = resp
}

// [END apigeeregistry_v1_generated_Provisioning_CreateInstance_sync]

redpajama_set_name: RedPajamaGithub


text:
Q: Configuring cxf service listing in karaf It is a web service deployed on Apache Karaf using camel-cxf. I am able to see the cxf service listing in URL localhost:8181/cxf which has some rest and soap services deployed on it.
The problem is it is returning the service listing whenever any request comes with keyword  "services". For example the url http://localhost:8181/abcd/services returns cxf service listing page instead of processing the actual request.
I got to know from http://cxf.apache.org/docs/jaxrs-services-description.html  that its is because of the default value of service-list-path of CXFServet is services.
Here is my Question. If I want to override this, I should set this property in etc/org.apache.cxf.osgi.cfg. This cfg file is not present under  etc folder in my karaf. What are the steps to be taken if I am creating this property file manually? What features I need to install? Or creating this cfg is sufficient ?
Appreciate your help !

A: There should be no extra installation requirements, just create a new file etc/org.apache.cxf.osgi.cfg.
There are three settings you may be interested in:
org.apache.cxf.servlet.context = /mycxf
org.apache.cxf.servlet.service-list-path = /myservices
org.apache.cxf.servlet.hide-service-list-page = false

Where the default URL for the CXF service listing is usually like http://localhost:8181/cxf/services, with the changes above the URL would become http://localhost:8181/mycxf/myservices
If you change from false (default value) to true, then your services will be hidden and you will instead get a page stating No service was found.
Because these are initialisation settings you need to shut down Karaf for the changes to apply.

A: I see several points here --

*

*The CXF framework is installed by default in karaf under the context-path /cxf.

*/cxf/services can be considered as a CXF internal app that displays the list of services deployed in CXF. I don't think you can configure the name "services" here (and why would you change that?)

*the "url-pattern in web.xml" you speak of (if I understand correctly) determines the context path of your servlet/application. You can specify this is camel like this:
<cxf:rsServer id="secureRsServer" address="https://0.0.0.0:8182/my/path/"
                      serviceClass="....">
(for the RS Server, probably same for the WS server).

redpajama_set_name: RedPajamaStackExchange


Cal Poly's chapter of the American Marketing Association (AMA) will host its annual professional development and student recruiting event, the Marketing Career Conference, on Friday, Feb. 17 from 9 a.m. to 2 p.m. at the Performing Arts Center on campus.
The career conference aims to link Cal Poly marketing students to professionals and alumni who can offer career opportunities and mentorship. This year's theme, "Coloring Outside the Lines," aims to inspire marketing students to imagine a unique future and then find the job or internship that will help pave the way for success after graduation.
Rex Briggs, founder and CEO of Marketing Evolution, will provide the keynote address at 10:10 a.m. in Phillips Hall. Briggs is a recognized expert in marketing return on investment.
The event will also feature a student pitch competition judged by a panel of industry veterans. New this year is the Creative Showcase Competition, where students can display creative marketing portfolios and gather feedback from marketing professionals.
The Marketing Career Conference will also feature dynamic industry panels and multiple networking sessions with industry leaders who are looking to fill internship and career positions within their organizations.
Business professional attire is highly encouraged, and a light lunch will be provided for attendees. For more information visit calpolyama.org/mcc or send your questions to calpolymcc@calpoly.edu. Register to attend at calpolymcc.eventbrite.com.


The Two Bedroom Executive Spa Pool Villas with private heated pools are the ideal choice for travelers seeking the ultimate escape in luxurious surroundings. Measuring a generous 150-200m² the Two Bedroom Executive Spa Pool Villas can accommodate up to four guests.
All charmingly adorned villas come with two exceptionally designed master bedrooms with private bathrooms, a spacious living room and an open plan kitchen. Spend an evening on the sun terrace and enjoy a dip in a private infinity heated pool for an unforgettable holiday. Pool heating is included in the rates for 14.04-24.05 and 28.09-31.10. In addition, guests can indulge in their own private spa, steam bath or sauna as well as staying health conscious in a fully equipped gym.


text:
Homes for sale in San Francisco, CA
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The average price of homes for sale in San Francisco is $2,227,888, with the highest listing price at $45,000,000 and a low of $180,000. The average listing price for San Francisco is 131% more than the average of California of $964,727.


Studio Apartments – Available February.
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Call our office now for more information. 518-561-4347.


text:
Ad Hoc Expert Group Meeting on Population, Agriculture and Environment: Opening Statement By Josué Dioné, Director Sustainable Development Division United Nations Economic Commission for Africa
United Nations. Economic Commission for Africa.; African Union Commission
"Dioné, Josué; United Nations. Economic Commission for Africa.; African Union Commission (2003-04). Ad Hoc Expert Group Meeting on Population, Agriculture and Environment: Opening Statement By Josué Dioné, Director Sustainable Development Division United Nations Economic Commission for Africa. UN. ECA Ad Hoc Expert Group Meeting on Population, Agriculture and Environment (2003, Apr. 22-24: Addis Ababa, Ethiopia). Addis Ababa:. © UN. ECA,. http://hdl.handle.net/10855/31296"
Regional Ministerial Review Conference on DND/ICPD at 10: Opening Statement By Josué Dioné Director, Sustainable Development Division Economic Commission for Africa
"Dioné, Josué; United Nations. Economic Commission for Africa. (2004-06). Regional Ministerial Review Conference on DND/ICPD at 10: Opening Statement By Josué Dioné Director, Sustainable Development Division Economic Commission for Africa. UN. ECA International Conference on Population and Development (10th: 2004, Jun . 7-11 : Dakar, Senegal). Addis Ababa:. © UN. ECA,. http://hdl.handle.net/10855/31291"
Opening statement of Mr. Babatunde Osotimehin executive director United Nations Population Fund
"Osotimehin, Babatunde; United Nations. Economic Commission for Africa. (2013-10). Opening statement of Mr. Babatunde Osotimehin executive director United Nations Population Fund. UN. ECA African Regional Conference on Population and Development (2013, Sep. 30 - Oct. 04: Addis Ababa, Ethiopia). Addis Ababa:. © UN. ECA,. http://hdl.handle.net/10855/31028"
ICPD at 10 Conference: Ministerial Review Conference on the Implementation of the Dakar/Ngor Declaration (DND) and the Programme of Action of the International Conference on Population and Development (ICPD-PoA)
"Amoako, K.Y.; United Nations. Economic Commission for Africa. (2004-06). ICPD at 10 Conference: Ministerial Review Conference on the Implementation of the Dakar/Ngor Declaration (DND) and the Programme of Action of the International Conference on Population and Development (ICPD-PoA). UN. ECA International Conference on Population and Development (10th: 2004, Jun . 7-11 : Dakar, Senegal). Addis Ababa:. © UN. ECA,. http://hdl.handle.net/10855/31251"
International conference on Population and Development (ICPD +15) Ministerial Conference: statement by Mr. Abdoulie Janneh, UN Under Secretary General and Executive Secretary of ECA 23 October 2009, Addis Ababa
"Janneh, Abdoulie; United Nations. Economic Commission for Africa. (2009). International conference on Population and Development (ICPD +15) Ministerial Conference: statement by Mr. Abdoulie Janneh, UN Under Secretary General and Executive Secretary of ECA 23 October 2009, Addis Ababa. UN. ECA Regional Review Conference on the Implementation of the Dakar/Ngor Declaration and the Programme of Action of the International Conference on Population and Development (ICPD) (2009, Oct. 20-23: Addis Ababa, Ethiopia). Addis Ababa:. © UN. ECA,. http://hdl.handle.net/10855/31093"
Statement of H.E DR. Salim A. Salim, OAU Secretary General: at the opening ceremony of the inaugural meeting of the OAU population commission
"Salim, Salim A.; United Nations. Economic Commission for Africa. (1994-05). Statement of H.E DR. Salim A. Salim, OAU Secretary General: at the opening ceremony of the inaugural meeting of the OAU population commission. AU Inaugural Meeting of the OAU Population Commission (1994, May 16: Addis Ababa, Ethiopia). Addis Ababa:. © UN. ECA,. http://hdl.handle.net/10855/31567"
African regional conference on population and development ministerial segment: Statement by Carlos Lopes, UN Under-Secretary-General and Executive Secretary of ECA
"Lopes, Carlos; United Nations. Economic Commission for Africa. (2013-10). African regional conference on population and development ministerial segment: Statement by Carlos Lopes, UN Under-Secretary-General and Executive Secretary of ECA. UN. ECA Africa Regional Conference on Population and Development (2013, Oct. 3: Addis Ababa, Ethiopia). Addis Ababa:. © UN. ECA,. http://hdl.handle.net/10855/36498"
African regional conference on population and development ministerial segment: Speech By Dr. Carlos Lopes, UN Under-Secretary-General and Executive Secretary of ECA
"Lopes, Carlos; United Nations. Economic Commission for Africa. (2013-10). African regional conference on population and development ministerial segment: Speech By Dr. Carlos Lopes, UN Under-Secretary-General and Executive Secretary of ECA. UN. ECA African Regional Conference on Population and Development (2013, Oct. 03 -04 : Addis Ababa, Ethiopia). Addis Ababa:. © UN. ECA,. http://hdl.handle.net/10855/36494"
Sixty Third Meeting of The Council of Ministers of The Organization of African Unity: Statement by K.Y. Amoako, UN under-secretary general, executive secretary, ECA
African Union Commission; United Nations. Economic Commission for Africa.
"Amoako, K.Y.; African Union Commission; United Nations. Economic Commission for Africa. (1996-02). Sixty Third Meeting of The Council of Ministers of The Organization of African Unity: Statement by K.Y. Amoako, UN under-secretary general, executive secretary, ECA. AU Council of Ministers (63rd: 1996, Feb. 26-28: Addis Ababa, Ethiopia). Addis Ababa:. © UN. ECA,. http://hdl.handle.net/10855/31489"
17th Meeting of the Technical Preparatory Committee of the Whole (TEPCOW): Opening address by K.Y. Amoako, executive secretary, ECA
"Amoako, K.Y.; United Nations. Economic Commission for Africa. (1996-04). 17th Meeting of the Technical Preparatory Committee of the Whole (TEPCOW): Opening address by K.Y. Amoako, executive secretary, ECA. UN. ECA Technical Preparatory Committee of the Whole Meeting (17th : 1996, Apr. 30 - May 03 : Addis Ababa, Ethiopia). Addis Ababa:. © UN. ECA,. http://hdl.handle.net/10855/31488"
Amoako, K.Y. (3)
Dioné, Josué (2)
Janneh, Abdoulie (1)
Osotimehin, Babatunde (1)


Will Wright is a genius! Watching this a single time is probably not enough because I take notes all the time. One of the best classes for me!
My favorite part of the Sims was always designing the houses and then decorating them. I'm interested to see how he thinks about building these worlds and the rules in the games.
Best Course I ever taken in Game Design. Such a cool teacher and pioneer in game making. Please fix the Diploma glitch bug MasterClass. I have watched ALL chapters many times over. Still cannot have my diploma for this course. Thank you for the course though! Invaluable for my game creative future. For anyone's game creation future! Thank you Will Wright! One day I hope to thank you in person with a game of my own in my hand. Or at least a great concept prototype!
Sims - getting to max cook level Game concept In Cooking Academy, players take the role of normal people that want to learn how to cook delicious dishes. Players will get a goal to achieve at their chosen class, take classes, get ingredients and learn how to cook delicious meals. Any player that achieve the goal of its class will win against the game and the player who achieve its goal in the best possible way will be the number one student of Cooking class. Win states Completing your goal card makes you win against the game Getting the highest note on you goal card makes you the number one student of Cooking Class Lose states Not completing your goal card makes you lose against the game Not getting the highest note on your goal card makes you lose against the other players. Hope to get some feedback and also help by sharing how i approached this assignment.
I joined masterclass for the writing classes and thought this would be one of the last things I'd ever be interested in watching. Goes to show that you need to go beyond your comfort zone and explore outside your interests! This is all so interesting!
People do not realize the historical perspective behind games. Native Americans solved many of our intertribal issues using games notably Stickball. Disputes between villages or tribes were more likely to be settled by stickball than the great expense war depletes blood and treasure for families and tribes. War was not as predominant fact of life as historians. Stickball was a suitable alternative substitute. Opposing tribes gathered their teams then camped on one end of the chosen field while the other tribe took up an opposite position that could extend to a couple of miles. Warriors from both tribes would ride back and forth taunting the other tribe at all hours of the day or night. Players would begin their fast abstaining from certain foods and only drinking herb teas provided by Shamans. Betting and food tables were set up for both teams to wager anything from trinkets to horses, wives, and even children. People outside the tribes were also allowed to watch and bet. Before the game began, the disputed issue between the two tribes is determined as that game's greatest trophy. Losing team must accept defeat honorably and agree to the victor's claim. Majority of the time this was the honorable solution to avoid war unless a tribe felt cheated then a war would start. The night before the contest both tribes would feast and honor their players. Shaman would bless the players and notch their sticks (kapucha) to draw more blood from their opponents. The players would be worked up in a frenzy of anger that would maximized shortly before the game started. There was great pageantry in pre-game by both tribes slowly walking their teams in a parade. Teams would begin jeering and taunting the other team as would spectators. Women and children would gather along the 'sidelines' to assist with injured players. A Shaman would throw the ball (towa) into the air to being each quarter of time. Today it is four 15 minutes quarters. In the past the game could go on as long as 12 hours of daylight. The length of the game and scoring limits were established before the game began. Shaman and medicine men were coaches on the sidelines. Stickball is a uniquely North American and one of the oldest recorded team sports. It is a tradition belonging to tribes of the United States and Canada. After a bloody match in 1892 by two tribes settling a dispute, US Gov't made it illegal to hold the matches without deputy marshals to prevent outrageous cruelty and violence. The game played today is not that different than the historical version as far as game rules. Today's contests are held on football fields with 'poles' set up at each end of the field.
Games Played I have been playing games for a long time, and my memories of them have been rekindled due to this assignment. Some of the examples include Simcity, The Sims, Sim Ant, All the C&C's and Red Alerts, StarCraft and the Original RTS of Warcraft games, Black and White, Dust, Annon, Incredible Creatures, Spore, Sim Earth, No Man's Sky, Afterlife, Civilization games, Plague Inc…, Age of Wonders, Simulators like Flight, Train, Truck, etc… What I found happens is just like how it was when I was playing with toys as a kid my mind finds a narrative. A story for why these things are doing what they're doing. It becomes a story, a different world that I am observing and participating in. Game Concept Idea Go Green, An Earth Saving Experience. Coming close to becoming extinct we need to fight against the clock to save our planet. Develop technology to battle the devastation that humans left behind. Save wildlife in trouble, replant vegetation and coral, save animals. Clean ocean from plastics, clean land from pesticides etc… Bring life back onto the planet. Chairs Foldable metal chair They're cheap to produce, are foldable, save a lot of space very lightweight, and you can stack them in a corner or on top of each other for easy storage. You can move them easily from place to place. The loss in these cost-effective chairs are comfortable, and aesthetics. Gaming Chair Very much focusing on comfort, aesthetics, mobility, support of back, and ability to recline. It goes around the moderate area with cost, great material, with beautiful stylish details, medium in weight. Can take up more space than required, so will have to space them out one per desk. Artist Made Chairs eg. The Dragon Chair Beauty is one of the main aspects of these chairs, highly focused on aesthetics, details, material, It's one of a Kind Comfort seems to be there, however, it's more of a statement piece. Chairs unreasonably expensive, and looks extremely heavy to move.
My first thought when seeing these chairs was yuck. But after taking the time to follow through on the 'thought' expirement on paper. I started to like Verner for his goals. Cheap, durable, portable, aesthetic different but modern. Breuer seemed like some horrid middle ground, ugly yet not as cheap, durable, easy to clean or modern as Verner. And Eames seemed like the most comfortable, but now I get why you wouldn't want an office or public space full of them, hard to manuever, hard to clean and non very stackable. It was worth the time to do this exercise!
Can someone help please ? Where is the best starting point to become a game designer/developer ?
I use Design Thinking to create Hyper Personalised Experiences. Thought this class would help me inject some Game Design into our experiences. Get start & very excited.


text:
Taikkun's Tibetan tourists' prayer-powered LEDs
By Rain Noe - April 28, 2009
City officials in New York occasionally have to remind us residents that while tourists are occasionally irritating, they are an important source of revenue for our city and should be treated like guests.
Designer Taikkun Li is taking that a step further, and treating tourists like an energy source with his Prayer Wheel Energy Generator, envisioned for Tibet:
Tourists traditionally spin a multitude of prayer wheels in Tibet. Now that positive energy can be harvested along Tibetan streets, turned into electricity, and used to provide evening lighting along those streets and inside the adjacent homes.
The prayer wheel generator is built on a base of used bicycle parts and a discarded surplus fan motor, making it ideal for use in the developing world. This invention supplements an inadequate and unreliable electrical grid with the power of electricity generated by tourism. By combining the low-cost efficiency and long life of 21st century LED lighting, with the simple 20th century efficiency of a bicycle, the Prayer Wheel Generator uses the best of high and low technologies.
I do my part to help NYC tourists by giving out unsolicited directions; at least twice a week I orient a map-studying pack of peeps. But if they were somehow making a dent in my Con Ed bill, heck, I'd cook 'em dinner.
Shalin
What a neat idea! ...although, for such a communal item, I'd hope it's hypo-allergenic, etc.
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Rain Noe
I'm a lapsed industrial designer. I was born in NYC and figured I'd die there, but a few years ago I abandoned New York to live on a farm in the countryside with my wife. We have six dogs.
Object Culture


A nice range of products. It is coming up to Valentine's day.....hint hint!
and you get a nice pouch with 6 products with code BEMINE when you spend £55.
The Armani Si one in particular looks like a steal!
Ha ha I guess I'm late to the party.
@Priya_13 I only noticed recently I have seen some other bag before. I'm definitely tempted but trying to be selective on what I buy more quality then quantity. And definitely need to use up what I have.


The Burnet Rd VIP 🐶 at The Local Post (the old Dallas Nite Club) wants to see you and your favorite pup 🐾 Join the Pawty and help support @emancipet ! Good food, drink specials, raffle prizes , amazing local vendors 😍 Come pickup your Life's Balance Pet Chews and special pricing on our entire product line. Come join us for HH and start your Friday off with your pet!!


Posted on Monday, February 3rd, 2014, by Brenda Pottinger under Favorites.
There are few places that include the elegance of the Cincinnati city skyline and the fun of sharks! The Newport Aquarium is the perfect place to celebrate a wedding. Their unique ballroom is great for an evening reception. And the exhibits are so much fun for guests to explore during cocktail hour. It is truly one of my favorite Cincinnati wedding venues. For this styled photo shoot we pulled together some of our favorite wedding professionals to show off the unique space.


Stokke® is proud to announce that our High Chairs and Bouncers are certified by JPMA and meet or exceed all ASTM safety standards. The softly cushioned bouncer has a unique cradling movement that mimics the feeling of being cradled in mothers arms. Developed together with a Paediatric Physiotherapist, our Newborn Insert ensures that your newborn baby will be properly supported when placed in the bouncer. The detachable toy hanger keeps your little one´s favorite toy close at hand.


There's something about DIY that gets your enthusiasm flowing and your adrenaline running; there's a great deal of pride in getting things done around your home with your own hands, and you feel an immense sense of satisfaction when you get the job done right because you've reduced your expenses and contributed handsomely by way of effort. However, for DIY projects to get done without any major hitches or hurdles, you need to know what you're doing, have a plan, and work according to it. Success in DIY depends on taking all the precautions necessary, avoiding giving in to cockiness and know-it-all behavior, and listening to words of wisdom if they're offered by professionals and others who have been there, done that before you.
Set a schedule before you do anything else – if you're an amateur, allow extra time for unforeseen circumstances and for just starting out slowly and steadily.
Tackle one room at a time – push all the furniture to the center, remove all the paintings and photographs and other paraphernalia from the walls, and cover them all with a tarp so that you don't get paint all over your stuff. Also spread cloth over the floor because that's where most of your paint is going to spill or spatter.
Spend the first few hours buying all that you will need and setting up your workspace – paints, brushes, rollers, paint rags, thinners, spackle, sanders, can openers, hammers, screwdrivers, and any other tool you think you may need. You may not want to walk around the house with paint all over you.
Ensure that you've covered yourself with overalls to avoid getting paint all over your clothes. And if you're painting the ceiling, cover your hair and wear protective eye-gear.
Clean the walls with a damp cloth before you paint over them; also remove peeling and cracked paint and then sand the walls before applying a new coat of paint.
You may have to fill in holes or cracks in the wall with spackle before applying a new coat of paint. Get this done first instead of stopping midway and having to wait for the spackle to dry before you can paint over it.
If there are wall or ceiling fixtures that cannot be removed, cover them with large plastic bags so that you don't get paint drops on them.
If possible, remove door knobs and handles other fixtures before you start painting, or at least cover them with plastic sheets.
Stir the paint after you open a new can, and pour it into another smaller container instead of dipping the brush directly into the paint can.
Talk to a professional painter before you begin, and find out how you can go about the task for the best results. Ask if you will need to use a primer, what kind of brushes will work best, and how you can get the job done faster and more efficiently.
You may encounter a few hurdles along the way, but if you figure out where you've gone wrong and how to correct your mistakes, you soon have a freshly painted room.


In this third Boss Taurus collaboration with Cellarbrations Carlisle and its associated beer club, Grain Cru, the whiskey barrel aged imperial dark ale has really come into its own. What debuted in 2015 as a barrel aged, imperial version of Bootleg's core range Raging Bull now feels more standalone – a majestic bull in the Bootleg paddock, something that bovine enthusiasts will note the name riffs on.
Aromas of choc-caramel fudge, vanilla, a hint of soft liquorice and a tease of the whiskey to come lead the way, with tasting only amplifying these as dark stonefruit and cola arrive, riding on a wave of warming booze and locally sourced stave-derived dryness. Although a mid-October release, this sipper deserves an open fire and contemplative mood to best celebrate its full expression.
As an aside, it's interesting to see the inclusion of the production year on this label, something that's becoming more commonplace in higher ABV, cellar worthy beers. This not only extends on some of the recently released IBA guidelines but will make vertical tastings easier to understand when deep into sampling beers with alcohol content nearing double figures.


This week the guys are talking about simulators, more specifically Farming Simulator 17. Dan has become King in Crusader Kings II and is playing Factorio, while Dudley has been playing The Witcher 3. They are both excited about the fast approaching PAX South convention and Dan expresses concerns about meeting one of his favorite authors, Patrick Rothfuss.


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northernillinoiscouponing.com
Question: How Much Is Miley Cyrus Worth?
How much is Liam Hemsworth worth?
What is Britney Spears networth?
How much money is Katy Perry worth?
How much is Miley Cyrus Worth 2020?
Who is richer Katy Perry or Taylor Swift?
What is Lady Gaga worth?
How much is Miley Cyrus husband worth?
How much is Brad Pitt worth?
What is Tom Cruise worth?
How is Gwen Stefani so rich?
What is Selena Gomez's net worth?
Who is richer Miley Cyrus or Taylor Swift?
Who is successful Katy or Taylor?
How Much Is Demi Lovato worth?
What is Taylor Swift net worth?
Liam Hemsworth's net worth is an estimated $26 million.
Hemsworth's Hollywood career started in a very big way—he was one of the original contenders for the lead role in Thor, a role that his brother Chris is now famous for..
Here's how the pop icon makes and spends her money, from Target shopping trips to California mansions. Britney Spears offered on Instagram to buy three fans necessities amid the coronavirus pandemic. Her net worth is $59 million, according to financial documents.
Katy Perry Net Worth: Katy Perry is an American singer, songwriter and television judge. Katy Perry's net worth is $330 million dollars.
It was released on Netflix on June 5, 2019. As of 2020, Miley Cyrus' net worth is $160 million.
Forbes' annual ranking of the best-paid women in music is out this week, and the name atop this year's list is Katy Perry — who pulled in $83 million between June 2017 and July 2018, beating out Taylor Swift (who netted $80 million) and Beyoncé ($60 million), according to pretax earnings sourced from Nielsen, insider …
With money from her album sales, successful tours, song play royalties and endorsements, Lady Gaga's net worth is an estimated $275 million.
Miley Cyrus and Liam Hemsworth have a reported net worth of $186 million. Here's how the newly-married couple made their millions.
Brad Pitt's primary sources of income are through his acting projects and through his production company Plan B. His estimated net worth as of 2020 is $300 Million. He has appeared in Forbes' list of the Highest-Paid actors in the world multiple times, notably in 2015 and 2016.
Tom Cruise – $570 Million His estimated net worth of $570 million ranks him third on the list.
Through a combination of singing with a group, launching a solo career, and being a judge and mentor, Gwen Stefani has been able to earn $100 million. She is still going strong. She has a personal relationship with Blake Shelton, so her name continues to be in the limelight.
She is worth $75 million in 2020, according to Celebrity Net Worth. This is even more impressive, given that she was estimated to have a net worth of around $60 million in 2019.
Though Taylor Swift has a higher net worth than Miley Cyrus, the two celebrities aren't interested in keeping every cent of their income to themselves. Swift and Cyrus enjoy donating large amounts of money to their favorite charities and have even been recognized for their generosity.
Katy has sold more than 100 million records worldwide. Here's one of Taylor's most signature hits. Taylor was a country-pop star before "You Belong with Me," but this song definitely turned her into a pop phenomenon. … This is her pop debut in so many ways, and she has clearly made even more hits since.
1. What is Demi Lovato's net worth? Lovato is worth an estimated $40 million, according to Celebrity Net Worth. If you take into account that she's only 27 years old, it's a pretty major accomplishment.
Swift's net worth is an estimated $360 million, and she's one of the world's highest-paid celebrities. Swift's Reputation Stadium Tour was the highest-grossing tour in US history, grossing over $266 million. Swift spends her fortune growing her real-estate portfolio across the US and donating to causes and charity.
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What are the major types of works? First, let'
Quick Answer: Is Slow Reading A Disability?
Is it better to read fast or slow? There is no connection
Quick Answer: Who Is The First Most Beautiful Girl In The World?
Who is the prettiest girl on Tiktok? The Sexiest &
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Which foreign language is in demand? Here'
How Do I Make A Post Public?
How can I tell if a post is public? Look for the little
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Is dyslexia a form of retardation? It does not result
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What causes RNAi? In a wide variety of organisms, including
Quick Answer: Can You Make Money With 10k Followers On Instagram?
What happens when you reach 1000 followers on Instagram?
Question: Who Is The Most Paid Actress?
Who is the richest actress in 2019? Scarlett Johansson
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How do I find old memories on Facebook? "
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Why is learning a third language easier? Every new
Question: Can We Earn Money From Instagram?
Can Instagram pay you? No, Instagram does not pay you
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What monthly report means? Writing a monthly report
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Child's Play Inc. is a full service, award winning, turn-key park and playground company operating in Northern Texas and Oklahoma since 1996. As an industry leading company with over 20 years in business, Child's Play Inc. is your one stop shop when it comes to Park and Playground Equipment. Whether you are looking for a shade canopy, sports goals, surfacing, pavilions, playground equipment, outdoor musical equipment, or a fully accessible playground, Child's Play Inc. is the company for you. Our qualified staff can make you decisions easy and help you through every step of the process from budgeting, fund raising to the design and sales process, and even during the installation and service after the sale. We value each and every potential customer and will go the extra yard to be sure you become a happy customer. Making happy customers is what Child's Play is all about.
We have the means to source items even if it means going to a competitor for that one item you want - "Don't make a mistake because of one item you want." Building your dream and making a Happy qustomer is what we are all about."
Show a discount and add money back into the freight & or installation. Ask us if your quote shows this?
Claim to get equipment from multiple high quality US manufacturers, change the model number or name and mark them up for a higher list price and lead you to believe 50% off this marked up price is a good deal. Remember, 50% off of 150% is not a good deal! Check with us to see if you quote comes from a legit company & compare pricing.
Claim their warranty is the same, because their plastic is warranted for 15 years, and don't tell you their warranty is prorated similar to a car battery. They also don't give you a new warranty when an item is warranted and that item may break again and you get stuck paying 100%. Let us give you a true side by side comparison.
Sell foreign playground equipment, which has sub-par quality of plastic that fades or cracks before reaching the 8th year. Whatever you do, check with us first. Buy the best quality, US made playground equipment at the best price – Call Child's Play Inc.
Blame installation problems on their installation company & because they are owned by separate owners they have no control over getting the issues fixed. They have done all they can do. Let us take control of your project and offer you a turn-key solution for all your playground & recreation needs.
Claim Child's Play Inc. cannot offer what they offer and cannot do what they say they can do. Let us explain to you how we can do what makes our competition so mad and claim we can't because they can't. Competition is good for the buyer!
Copyright 2019 by Child's Play, Inc. All rights reserved. Website designed by Foremost Media®.


Paper Rose Boutonnieres. CHOOSE YOUR COLORS, Books, Etc. Any Amount, Colors, Theme, Etc. Custom Orders Welcome.
This listing is for paper rose boutonnieres, in the colors of your choice! I can also do these from books. Order as few or as many as you need!
---> Let me know what paper you would like for the rose flower, and what colors you would like for the accent flowers. I have tons of colors! I can also make the roses out of books, magazines, patterned papers, comics, maps, sheet music, etc.


Fecund farmland in a prime location. This rolling land is fully fenced and cross fenced, including 7 acres of pecan groves, a well, electric, and corral. Paved road ties into SR21 at one end, and US Hwy 301 at the other, giving easy access to Historic Melrose, Gainesville, Ocala, Palatka, and surrounding cities. A must see in North Central Florida's lake region!


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FCC Proposes Folding SLC into USAC by Year's End
The Federal Communications Commisison proposed to Congress May 8 that the Schools and Libraries Corporation and the Rural Health Care Corporation be folded into the Universal Service Administrative Company (USAC), effective Jan. 1, 1999, and that USAC serve as the permanent, single administrator of the Universal Service Fund. The FCC said it would seek public comment on the proposals and consult with the Federal State Joint Board on Universal Service before taking final action.
In addition, the FCC said that next week it would seek comment beginning next week on whether funding for the E-rate program should equal demand or be limited to an amount that does not cause long distance rates to rise. The FCC said that according to its preliminary calculations, the program could be funded at approximately $1.67 billion this year without increasing the payments long distance companies would have to pay. The SLC previously estimated that through April 28, it had received applications for $2.02 billion in E-rate funding. The FCC had previously set a cap of $2.25 billion for the program.
The FCC also said it would seek comment on the extent to which long-distance carriers are not providing "complete or truthful information" regarding universal service surcharges on their bills. In recent weeks, carriers have said they would begin detailing these charges to their residential customers.


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Q: Which SQL server is running on a Linux Box? I have a redhat linux server that I am trying to work out what is running on it.  I have inherited it and am trying to move it to a different server.
I know there are several SQL databases running on it but I don't know what SQL package is controlling them.
Is there a way to find out?

A: You can use the Red Hat services command to get a list of daemons running. One of them should be the database server.
sudo service --status-all

And if that doesn't work (e.g. it's not being run as a service) you can always do
ps -ef|grep 'postgres|mysql|oracle|sql'


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Q: How to declare an Array of angular Material modules? Questions such as this one, and various blog posts, recommend a separate module to import your Material Modules and immediately export them, then import that module into your app.module.ts to prevent polluting the app module.
It seems to me that if imports are always identical to exports then I would prefer to declare them only once. So, I use
const materialModules = [
  MatButtonModule, MatIconModule, MatFormFieldModule, MatInputModule, MatNativeDateModule, MatDatepickerModule,
  MatCheckboxModule, MatSidenavModule, MatToolbarModule,
];

@NgModule({
  imports: materialModules,
  exports: materialModules,
})

export class MaterialModule{}

This works fine, but I would like to give a type to materialModules. What should it be?

A: Well, these modules are passed to imports array and since imports take the below type:

(any[] | Type<any> | ModuleWithProviders<{}>)

We don't have any other options other than the above type.
So you can do
 const materialModules : (any[] | Type<any> | ModuleWithProviders<{}>) = [
  MatButtonModule, MatIconModule, MatFormFieldModule, MatInputModule, MatNativeDateModule, MatDatepickerModule,
  MatCheckboxModule, MatSidenavModule, MatToolbarModule,
];

But to me it doesn't add much benefit.


FDIC Versus Maxxam and Milken!!!
MICHAEL R. MILKEN, et al., Defendants.
171. At the direction of the Milken Group, USAT purchased approximately $1.4 billion of Drexel-underwritten junk bonds. In-exchange, the Milken Group financed a number of business schemes for Charles Hurwitz, the primary owner of United Financial Group, Inc. ("UFG²), USAT's parent.
172. In mid-1983, Hurwitz, through two companies he controlled, Federated Development Co. and MCO Holdings, Inc., acquired approximately 23% of UFG. As of March 1985, the Milken Group had caused Drexel to acquire 7.2% of UFG's stock, and by March 1987, the Milken Group had caused Drexel to increase its ownership interest to 9.7%. Drexel and Hurwitz were the largest shareholders of UFG during the entire period in which junk bonds were purchased by USAT, together-controlling more than 30% of UFG's outstanding stock from 1984 until 1988, when USAT failed.
173. Between 1985 and 1988, the Milken Group raised about $1.8 billion of financing for Hurwitz's takeover ventures. In return, Hurwitz caused USAT to purchase huge amounts of Drexel--underwritten junk-bonds.
In 1984, USAT purchased only $5 million of Drexel-underwritten junk bonds.
In 1988, USAT purchased over $58 million of Drexel-underwritten junk bonds.
174. The Milken Group placed much of the debt Drexel underwrote for USAT with its network. For example, about $272 Million face amount of the $615 million of senior subordinated -Extendible notes (the "zero coupon notes") underwritten by Drexel to finance Hurwitz's takeover of the Pacific Lumber Company ("Pacific Lumber") in 1986 was purchased by First Executive and various of its subsidiaries, Columbia and GNOC Corporation:on ("GNOC"), a subsidiary of Golden Nugget, Inc. ("Golden Nugget"). Similarly, the Milken Group placed a significant . amount . of the senior subordinated extendible notes issued in connection with the Pacific Lumber takeover with S&Ls, including AMCOR, a wholly-owned subsidiary of Lincoln, Federal Savings & Loan, Hunter savings Association and Pima.


groups and share what we liked best about spring.
the new recruit class. He then took questions.
John then had us discuss what projects need attention and how do we secure more volunteers.
at the end, have activities such as a plant swap.
please contact Tiffany Boyd, 317-236-7400 ext. 200.
May 9, at 2 pm. Please bring a dish to share.
Laura Tease, treasurer, was present to collect dues.
1252 Wright Street on HGTV's newest show.
May 5 – Primary elections – Get out and VOTE!
Mentors. Includes 70 live performances on 9 different stages along with art, food, and beer.
May 9 – Cinco de Mayo gathering, starting at 2 pm, South New Jersey Street.
butterflies and caterpillars love and help attract them to your yard. All materials will be provided.
Registration is required by May 10.
May 19 – Family Game Night – Fountain Square Library, 6 pm to 7:30 pm.


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Economic Community of West African States (ECOWAS) Commission and the Diplomatic Corps Resolve to Promote Inclusive and Peaceful Transitional Process in West Africa
The ECOWAS Commission and Political Officers/Military Advisors of the Diplomatic Corps have resolved to continue to promote inclusive and peaceful transitional process in West Africa.
This came to the fore during the briefing of the Political officers/Military Advisors of the Diplomatic Corps by the Mediation and Coordination of Political Affairs Division of the Political Affairs Peace and Security Department on the 24th of November 2022 in Abuja, Nigeria.
In his welcome address during the briefing, the ECOWAS Commission's Commissioner for Political Affairs Peace and Security (CPAPS) Dr. Abdel-Fatau Musah maintained that given the dynamics of political and socio-economic situation in the region, ECOWAS would continue its avowed role of accompanying its Member States on their democratic, peace and stability processes.
Stressing the importance of the facilitating role of the ECOWAS mediators to countries, under-going various forms of transition processes, Dr. Musah, noted that the current mechanisms of mediation and intervention should be periodically reviewed to accommodate best practices and ensure that a lot more is done beyond kinetic interventions by constituted authorities. He also stressed on the need to operationalize the regional Economic and Social Council (ECOSOC) within the next two years and bring civil actors in the region to the dialogue table.
The lead presentation of the briefing was made by the Director, Centre for Democracy and Development Dr. Idayat Hassan who expounded the various dimensions of the topic: Promoting an inclusive and peaceful transitional process in West Africa: The role of civil society in the transitional processes.
She identified two converging trends-Insecurity and contested elections as well as the underlying desire by some incumbent leaders to manipulate the democratic processes through non-inclusive constitutional changes.
Going forward and to stem the increasing threat of a relapse of dictatorial tendencies, she recommended among others, a critical look at the role of information disorder (mostly emanating from digital technology), disinformation, proliferation of actors and techniques as well as home grown solutions while ensuring that responses are driven by community actors and institutions.
The briefing which had an array of political officers and military advisors from the diplomatic corps in Abuja, featured robust exchanges of ideas and analysis, of the socio-political environment in the region also received goodwill messages from Mr. Thomas Kieler, the representative of the European Union Delegation to Nigeria and ECOWAS, who pledged the continuous support of the EU to the ECOWAS political intervention processes.
The bi-annual briefing, which is the second for 2022, serves as a structured platform, for interface and exchange of ideas on peace and security issues, between the ECOWAS Commission and the diplomatic community in Abuja.
Distributed by APO Group on behalf of Economic Community of West African States (ECOWAS).
United Nations High Commissioner for Refugees (UNHCR) warns rising tide of hunger, insecurity, and underfunding worsening gender-based violence risksEuropean Union funding helps millions access food as conflict engulfs Eastern Democratic Republic of the Congo


Raffles City Singapore is "the city within a city" designed by world-renowned architect I M Pei. Sitting right above the busy City Hall MRT Station, the integrated complex houses offices, hotels, a convention centre, a shopping mall and many eateries. There is a wide range of dining options and we share The Ordinary Patrons' list of favourite eating places – TOP Raffles City Restaurants and Cafes – for various occasions and budgets.
From fast food chains and food court to luxurious cafes and Michelin starred restaurants, Raffles City has something to offer whether you are there shopping, attending a meeting or staying in one of the hotels. There are grab and go food stands as well as trendy cafes to while away the whole afternoon. There are cheap and good food places and fine dining restaurants for intimate dinners. Here is our list of current favourite cafes and restaurants in Raffles City, depending on our mood and budget on any particular day.
The unpretentious Cedele Bakery Kitchen Raffles City is a place where we can eat well and feel well. The Cedele Wellness Menu offers interesting healthy options – affordably priced wholesome food made with quality ingredients which will be good for ordinary patrons who are watching weight, managing cholesterol levels, eating for a healthy heart or just eating to feel good. Read more.
JAAN is a modern French restaurant that is a top restaurant in so many ways. Perched on Level 70 of the hotel tower, the Michelin starred restaurant's lofty heights and expansive windows mean that it is one of the best restaurants with breath-taking views over Singapore. For special celebrations or when budget is not an issue, this will be our choice Raffles City restaurant. Read more.
Hyangtogol Korean Restaurant Raffles City is a branch of Hyang-To-Gol (향 토 골), which has been named as one of the world's top 5 overseas Korean restaurants by Korean Food Promotion Institute (formerly the Korean Food Foundation). The unpretentious restaurant has an extensive menu offering Hot Plate BBQ and classic Korean dishes like Ginseng Chicken Soup and Bibimbap. Hyangtogol Raffles City also has some attractively priced combo meals and lunch specials. Read more.
Prego is one of Singapore's favourite Italian restaurants. The restaurant is popular with the corporate types, especially for lunch on weekdays, and for a hearty dinner of classic Italian fare and fine wines. We think that brunch or breakfast at Prego Singapore is also a great option. Read more.
PS. Cafe Raffles City is a gorgeous dining space. Designed as a house within a building, PS. Cafe Raffles City is located in the sunlit atrium and has, besides their signature live plants and floral arrangements, a vertical garden behind the bar. The trendy cafe has an all day menu offering a fair selection of mains, sandwiches, pasta, a few Asian dishes and its signature cakes and tarts. Read more.
Putien Raffles City is located in an extreme corner of level 2 in a windowless space. The restaurant can be noisy and congested at peak hours but we can be sure we will get the same good food as the food served in the Michelin starred flagship restaurant in Kitchener Road. Read more.
Real Thai is tucked away in a corner of the basement. It is a fast food restaurant offering a good range of affordably priced Thai fare from Pad Thai and Boat Noodles to Mango Sticky Rice and Durian Samosa. Raed more.
SKAI Restaurant is an exciting contemporary grill perched on the 70th floor. With a great view and very good food, it is hard to think of a better place to have a meal in Raffles City than the wonderful SKAI Restaurant. Read more.
The atmospheric Raffles City restaurant bar has interesting cocktails and a menu of innovative dishes that draw inspiration from the chef's own cultures and travel experiences. The food of Botanic Restaurant is a showcase of global influences with Nyonya, Indonesian Thai, Chinese and Mediterranean flavours. Read more.
The Stamford Brasserie, with a three in one F&B concept comprising a Grab-and-Go, All-day Dining Restaurant and Beer Bar, is a new stylish spot for coffee and more. This cosy Raffles City cafe is one we will go to again and again. Read more.


Acquisitions play an important role in Epiroc's growth strategy. The goal is that all acquisitions shall create value.
In the list below you will find acquisitions made since 2012. Please click on the company name to view the press release.


This temple is dedicated to Lord Siva and was built during the reign of Pallava King Rajasimha during 685 – 705 AD. This temple was built in Dravidian architecture. There are 58 sub temples within the temple complex. Temple is 60 km from Mangadu Temple.
This temple is dedicated to Lord Siva and is one of the Panchabhootha Sthalams. Lord Siva represents The Earth element here. Temple is 59 km from Mangadu Kamakshi Amman Koil. The temple tower is of 59 ft tall and is the tallest Gopuram.
This temple is dedicated to Lord Vishnu and is one among 108 Divya Desam ( Holy abodes) of Lord Vishnu. This temple is 60 km away from this holy shrine.
The best time to visit is during Oct -Jan months, during this time migratory birds reach this place for reproduction. This place is 71 km from this temple. This lake formed from the backwaters and is interesting place near Kanchi. Painted storks, Little Egrets, Cormorants, Darter, Flamingos, Pelicans, moor hens, herons, kingfishers, sandpipers, white ibis, spoonbills, grey wagtails etc are commonly seen here.
This was built during the Pallava Kings during 7th and 8th Century AD. The rock carvings, monuments and temples are the major attractions. This place is 62 km from Mangadu. The direct bus is available from Chennai and Kanchipuram.
This is a museum depicting artistry workers, crafts, designs, folk arts, traditional architecture etc. This was established in the year 1984 and is 39 km from Mangadu.
This place can be reached from Mahabalipuram and is 12 km away. There are 6 different species with 5000+ crocodiles in this park.


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Christine Kipke
Christine Kipke is a communications and security expert. Christine is the co-founder of exploqii in Berlin, which has been a wholly owned subsidiary of KnowBe4 in the DACH region since 2018. As such, she has developed concepts for security awareness and compliance education formats for use by German and international companies, German security authorities, the public sector, and non-profit organisations since 2014.
The multi-lingual, multi-cultural security education content developed by Christine and her team has received multiple international awards.
In her role as managing director of the KB4 subsidiary, she trebled in the team in Berlin and joined the advisory board of the German subsidiary on 1 July 2020.
Before exploqii, Christine held various positions in the IT and media industries and acquired experience in theatre and television production early on. While working in front of and behind the camera, she became intimately familiar with the challenges and opportunities of the digital media. For more than 10 years, the communications and creative expert has worked in the field of explanatory video communication and for almost 9 years, has been an enthusiastic elucidator of all topics around security.
In 2019, Kipke received the Outstanding Security Performance Award as an outstanding female security expert. She regularly moderates panel discussions and events around security with international experts from business and politics. She is also a welcome panel guest and gives lectures on a regular basis.
She left the company at the end of June 2022.