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text:
Avillion Appoints Dr Allison Jeynes-Ellis as Chief Executive Officer
Avillion LLP
18 Feb, 2014, 09:00 GMT
LONDON, February 18, 2014 /PRNewswire/ --
Avillion LLP, a drug development company focused on co-development and financing of late-stage pharmaceutical candidates, from Phase 3 clinical development to marketing approval, announced it has appointed Dr Allison Jeynes-Ellis MB, ChB, FFPM as Chief Executive Officer (CEO). Dr Jeynes-Ellis has over 20 years of senior leadership experience in the pharmaceutical industry. She has managed both large and small teams focusing on global clinical development projects that have led to new drug approvals in Europe and the USA, across a range of therapeutic areas. Dr Jeynes-Ellis is a founding member of Avillion's management team and was formerly the company's Chief Medical Officer.
During her career, Dr Jeynes-Ellis has worked in senior roles in pharmaceutical companies, including Wyeth, Bristol-Myers Squibb, and Novartis; and as an independent consultant to many companies, including CAT and Genentech, government bodies and medical research charities. She was previously Medical Director at Wyeth (UK and Ireland), where she led a large team spanning various clinical development, regulatory affairs and commercial functions. Dr Jeynes-Ellis was also Medical & Innovation Director at the Association of British Pharmaceutical Industry (ABPI). She is a currently a non-executive director of the Health Research Authority and BioCity, Scotland.
Dr Allison Jeynes-Ellis said: "I am excited to accept this opportunity at Avillion. We are aiming to be a key partner to companies with promising late-stage clinical assets, which for reasons of funding or resource constraints are not being advanced as quickly as they could be. We offer these companies an innovative solution to accelerate the development of these product candidates through Phase 3 clinical development to marketing approval, for the ultimate benefit of patients."
Genghis Lloyd-Harris, a non-executive director of Avillion and a partner at Abingworth, said: "We are delighted that Allison has accepted the role of CEO. She has clearly demonstrated a range of skills that is well suited to driving the innovative clinical development model that Avillion operates."
Kurt Wheeler, a non-executive director of Avillion and a managing director at Clarus Ventures, added: "Allison was instrumental in Avillion signing its first collaborative development agreement with Pfizer, to conduct a global Phase 3 clinical trial evaluating BOSULIF® (bosutinib) as a first-line treatment in chronic myelogenous leukemia. We are confident that, under Allison's leadership, this agreement will be the first of several that Avillion signs over the coming years."
In taking this new role as CEO, Dr Jeynes-Ellis replaces Lewis Cameron who has left the Company to pursue other opportunities. The Board of Avillion thanks Mr Cameron for his contribution to the Company.
A photograph of Dr Jeynes-Ellis is available by contacting tasha@avillionllp.com or mark.swallow@citigatedr.co.uk
About Avillion
Avillion's mission is to have an impact on patient care by accelerating the availability of new and innovative drugs into the world's major markets. To achieve this, the Company provides strategic development and regulatory expertise, funding, global CRO management and risk-sharing to pharmaceutical and biotechnology companies to advance late-stage clinical development projects through to market approval.
Avillion was founded in 2012 in London, UK, and is backed by leading life sciences investors, Abingworth and Clarus Ventures.
Website: http://www.avillionllp.com
SOURCE Avillion LLP

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text:
X-Men Milestones
Louise Simonson y Chris Claremont
Collects X-Terminators #1-4, Uncanny X-Men (1981) #239-243, X-Factor (1986) #35-39 and New Mutants (1983) #71-73. The biggest and best adventures of Marvel's mighty mutants — these are the X-Men Milestones! Strike the match…fan the flames…and light the Inferno! Limbo's demon lords corrupt two of the X-Men's nearest and dearest — Colossus' sister, Illyana Rasputin, and Cyclops' wife Madelyne Pryor — and use them to bring a horde of demons raining down on New York City! But as Illyana battles to regain her soul, Madelyne threatens to cast a spell that will merge Earth and limbo permanently — with the sacrifice being her own innocent son! And when Mister Sinister brings his own agenda into the mix, secrets are revealed that rock Cyclops to the core! The X-Men, X-Factor and New Mutants face their most harrowing ordeal ever — with the fate of the world in the balance!
Más libros de Louise Simonson & Chris Claremont
Superman: The Man of Steel (1991-2003) #1
Superman: The Death of Superman (2016 Edition)
Wonder Woman: Warbringer
The Death of Superman: The Wake


text:
Not just skin deep: monoclonal therapies and pituitary endocrinopathy
Issue 122 Winter 2016
Endocrinologist > Winter 2016 > Features
Andrew S Powlson & Carla Moran | Features
Credit: 123RF
Primum non nocere or 'first do no harm' is a central tenet of medicine, and one to which physicians have aspired for millennia. In practice, physicians have been required to weigh the therapeutic benefit of an agent or intervention against its potentially harmful sequelae: a 'risk assessment' mandated, though with variable adherence, from the ages of blood-letting, leeches and elemental therapies through to the present day.
Of course, the more devastating and refractory to conventional therapies the disease is, the lower the threshold for acceptance of side effects. A therapeutic agent with foreseeable side effects may be more safely and efficaciously used with due vigilance and multi-disciplinary liaison. In some cases, that will mean different specialties working with us, as endocrinologists.
IMMUNOTHERAPY AND THE MEDICAL ONCOLOGIST
One therapeutic avenue which has become interdisciplinary is the use of immunomodulating agents which, in the simplest terms, involves modifying host immunity to target a disease process.
One of the earliest uses of humanised monoclonal antibodies to such an end came with the administration of alemtuzumab in the treatment of multiple sclerosis. Our experience of this alerts us to the potential for immunomodulation to result in an increased incidence of autoimmune disease against endocrine organs. Immune-mediated thyroid dysfunction is an important side effect of alemtuzumab therapy (occurring in 40% of patients treated at our institution). As such, both neurologists and endocrinologists recognise the need for vigilance and monitoring of thyroid function in individuals treated with this agent.
More recently, monoclonal antibody therapy has entered oncological practice, with the development of agents directed against immune checkpoint molecules such as CTLA-4 (cytotoxic T lymphocyte-associated antigen 4) or PD-1 (programmed cell death protein 1). Inhibition of these immunological 'checkpoints' modulates the T cell response to malignancy, enhancing the activity and proliferation of T cells and thus inhibiting tumour cell proliferation and survival.
Use of these agents is having a dramatic effect on the treatment of advanced melanoma, where untreated median survival is 8–10 months. The agents are now being explored for use in other malignancies.
Conversely, of course, such promotion of the T cell response can affect self-tolerance, in turn promoting development of autoimmune responses to native tissues, resulting in immune-related adverse events (IRAEs), including endocrinopathies.
Ipilimumab (Yervoy®, Bristol Myers-Squibb) was approved for use by the US Food and Drug Administration in metastatic or unresectable melanoma in 2011. It was the first drug to prolong the lives of patients with advanced disease.
This humanised monoclonal antibody targets the immune checkpoint antigen CTLA-4 and it has become increasingly clear that IRAEs are common with this agent. These include dermatological and gastrointestinal manifestations as well as the development of autoimmune endocrinopathies: most commonly hypophysitis, but also primary adrenal insufficiency and thyroid disease.
The extent of the issue has become increasingly apparent in recent years, as will have been evident to those attending endocrine meetings, where a veritable glut of case reports has appeared. A number of recent reviews consider the phenomenon in detail.1,2
The pathogenesis of ipilimumab-induced hypophysitis is unclear and no histological specimen from such a case has been reported, but the phenomenon is perhaps not unexpected. CTLA4 polymorphisms are associated with autoimmune endocrinopathies such as Graves' disease and Hashimoto's thyroiditis; the antigen is expressed on both mouse and human anterior pituitary cells and focal infiltration of macrophages and lymphocytes has been demonstrated in pituitary glands of anti-CTLA-4 treated mice.3
IPILIMUMAB-INDUCED HYPOPHYSITIS
The reported prevalence of hypophysitis in ipilimumab-treated patients varies by study (0–17%). It seems that earlier studies may well have underreported its existence, in part because of a lack of awareness and inconsistent monitoring and reporting measures. In turn, this may also reflect the ambiguity of the symptomatology of hypopituitarism, with headaches the most common presenting feature, along with other non-specific features of anterior hypopituitarism such as nausea, vomiting, weight loss, lethargy and confusion. Hyponatraemia may be evident; diabetes insipidus and visual compromise have been reported only rarely.
Table. Illustrative presentation of ipilimumab-induced hypophysitis: a 77-year-old man with metastatic melanoma had received two cycles of ipilimumab (commencing 2 months previously) before being admitted with lethargy, fatigue, dizziness, nausea and vomiting. He was markedly hyponatraemic with pan-anterior hypopituitarism.
Parameter Results Reference range
Sodium 122 133–146mmol/l
Adrenocorticotrophin <5 0–50ng/l
Cortisol at 9am (unstimulated) <25 280–650nmol/l
Cortisol (30min post-Synacthen) 33 >450nmol/l
Thyrotrophin 0.38 0.35–5.5mU/l
Free thryroxine 3.4 10–19.8pmol/l
Free tri-iodothyronine 2.0 3.5–6.5pmol/l
Luteinising hormone 2.2 1.5–6.3U/l
Follicle-stimulating hormone 1.5 1.0–10.1U/l
Testosterone 0.2 8–29nmol/l
Prolactin 6 45–375mU/l
Insulin-like growth factor-1 5.2 10–25nmol/l
Unlike idiopathic hypophysitis, which tends to predominate in females of reproductive age, ipilimumab-induced hypophysitis appears to have both male sex and age as risk factors. A dose effect is also present. Hypogonadotrophic hypogonadism, and secondary thyroid and adrenal insufficiency, are most common, with the growth hormone axis more rarely involved. This last observation may be due to limited assessment of the growth hormone axis in many studies.
Presentation occurs most commonly at 2–3 months post-initiation (mean 9 weeks), though delayed presentation has been reported. This tends to be later than for other IRAEs, such as gastrointestinal effects. Notably, some pituitary function may recover; up to 50% of patients regain thyrotrophin and gonadotrophin secretion in some series. In contrast, hypothalamicpituitary-adrenal axis recovery is rare, and several authors report persistent hypopituitarism. It is not clear how often and how robustly patients described in many studies were assessed for recovery of hypopituitarism.
Pituitary imaging may demonstrate a marginally increased anterior pituitary volume (mean increase 5mm) and/or heterogeneity of contrast enhancement. This appearance can precede the development of anterior hypopituitarism and may only be transiently evident, with all patients in one series showing reduction of radiological features after 40 days. The typical mild global enlargement may explain the lack of visual pathology in these patients.
Awareness of the potential for hypophysitis and its likely symptoms, and recognition of these should they manifest, are both key. This is perhaps where close liaison and mutual education between oncologists and the endocrine team are particularly important.
Figure. T1–weighted MRI with gadolinium in the same patient as described in the Table demonstrated a modest diffuse enlargement of the pituitary gland for his age, with some heterogeneity of contrast enhancement across the gland, consistent with hypophysitis.
Early advice suggested measuring thyroid function before commencement and before each subsequent dose. A more structured anterior pituitary and electrolyte profile before starting ipilimumab as a baseline would seem prudent, along with continuous assessment for clinical features and further anterior pituitary testing at intervals during and after the course of treatment. The possibility of late clinical presentation should be kept in mind.
Pituitary imaging should be considered if symptoms or biochemistry dictate. Once present, adrenal, and subsequently thyroid, insufficiency should be treated with physiological replacement doses. There is no clear evidence that supraphysiological (immunosuppressive) doses of glucocorticoid alter the recovery rate of endocrinopathies or resolve pituitary enlargement,4 though such doses are often prescribed and may be advised if, for example, there is a mass effect on magnetic resonance imaging (MRI).
Early papers suggested permanent discontinuation of ipilimumab in all cases, but more recently authors have suggested that it may be reintroduced after a delay once appropriate hormone replacement has been commenced.
Discussion between oncology and endocrinology is advised. An ongoing need for hormone replacement, and thus endocrine follow-up, is to be expected. Possible permanent hypopituitarism must be weighed against the potential life-extending benefits of ipilimumab. Indeed, it has been suggested that patients who develop hypophysitis, and thus have a greater immune response, may have a survival advantage.
'Of course, such promotion of the T cell response can affect self-tolerance, in turn promoting development of autoimmune responses to native tissues, resulting in immune-related adverse events, including endocrinopathies'
OTHER MONOCLONAL THERAPIES IN ONCOLOGY
Ipilimumab was just the first in a line of promising immune checkpoint modulators. More recent examples include monoclonal antibodies targeting PD-1, such as nivolumab and pembrolizumab. It has recently been suggested that these agents have an improved survival benefit over ipilimumab in advanced melanoma, and IRAEs seem to be less frequent and less severe. Hypophysitis is rarer with these agents (<1%), but thyroid disease is common (up to 9%) and may occur as transient thyrotoxicosis, thyroiditis or primary hypothyroidism.
Notably, combining anti-CTLA-4 and anti-PD-1 agents increases the risk of IRAEs, resulting in thyroid dysfunction in up to 22% of cases.
In summary, the efficacy of checkpoint modulating immunotherapies in treatment of advanced melanoma is resulting in their increasing use, and hence the prevalence of immune-related endocrinopathy is likely to rise. Currently, prospective studies and accurate data on recovery of endocrine dysfunction are lacking. Liaison between endocrinologists and oncologists is required to increase our understanding of the pathogenesis and course of these phenomena and to standardise care pathways.
Andrew S Powlson & Carla Moran
Wellcome Trust–MRC Institute of Metabolic Science, and National Institute for Health Research (NIHR), Cambridge Biomedical Research Centre
Faje A 2016 Pituitary 19 82–92.
Joshi MN et al. 2016 Clinical Endocrinology 85 331–339.
Iwama S et al. 2014 Science Translational Medicine 6(230) 230ra45.
Min L et al. 2015 Clinical Cancer Research 21 749–755.
Unpicking GnRH signalling dynamics: mathematical approaches
Endocrinologists and the consequences of cancer treatment
Endocrinology at the centre of everything


1) My number one tip is a microfiber cloth. I've become addicted to my microfiber cloth so much that I have spares. I use mine to clean brushes. What you want is a nubby cloth that's not too hard. The yellow one in this picture is perfect. There's enough texture to it that you can gently rub your brushes onto it and the color is removed. I clean all the brushes I use with powder products on this so I only have to wash my brushes biweekly. Saves me time and I just throw it in the laundry with my clothes, lay it out to dry, and I'm done. They dry quickly too. The ones I have are from Scotch but I think other brands would work well too.
2) Speaking of washing brushes, this is where Johnson's Baby Shampoo comes in. I've used this for years as an alternative to a brush cleaner. If you run out of your brush cleaner or just don't want to spend the money, try this gentle shampoo. I pour a small amount in a plastic cup without adding water. I swirl my brush/es around making sure that the product gets out. Next I pour that out, add some water, and swirl until the water runs clean. Don't put too much shampoo in since it's not needed. Next dab on a towel to get rid of the excess water, lay to dry, and VOILA – clean and nice smelling brushes.
3) Tip 3 is also using Johnson's Baby Shampoo and this comes from my ophthalmologist. He recommends washing my eye makeup off with this shampoo. I don't do that since I find mascara too stubborn. But I do have a small bottle of this in my shower and wash my eyes with it then. What my doctor recommended too is that any time my eyes bother me or I feel something building up that's the time to use this gentle "no more tears" shampoo. He told me this over 20 years ago and knock-on-wood it's been a perfect tip.
4) Everyone has tips for Vaseline Jelly. It's been around longer than any of us have been and is used so many ways. While I haven't tried it as an eye makeup remover, I've read that people do use it this way. One of the ways I use Vaseline Petroleum Jelly is when I color my own hair. I pull my hair back, apply Vaseline around the edges of my face so that my skin doesn't pick up the color. I also put it on my earlobes. As I'm washing the color out, I'm also washing away the Vaseline. Other uses are to protect skin against chafing and helping with dry skin.
5) A product I like even more than Vaseline is Waxelene which is an alternative to petroleum jelly. This makes a wonderful lip balm especially when your lips are horribly chapped. Waxelene is non-petroleum based, all natural, eco friendly, biodegradable, and has no GMOs. If you cut yourself shaving, apply Waxelene on it to stop the bleeding and help the healing. It really works. I also like to use this on the cracks on my feet.
6) Carbonated Water is your friend too. Two beauty related ways to use carbonated water or seltzer are on your hair. If you suffer from frizzy hair, use carbonated water as your final rinse water. It won't remove the frizz entirely but it will help reduce it. Also if you are in a chlorinated pool, rinse your hair after with carbonated water. It will restore luster to your locks especially if you color treat your hair.
7) Elmer's Glue can help you when you manicure your nails. To get a clean edge use an old brush and paint around the edge of your nails, let it dry, and then do your manicure. When done just peel off the glue and your nails will look like you had them done. There are more expensive products that are sold for this job but why not use a product that you probably have in your house or can use for lots of other uses?
8) No need to buy a fragranced body lotion when you can do double duty with your favorite unscented body lotion. My suggestions are Aveeno Daily Moisturizing Lotion Fragrance Free and Delectable Scent Free Body Lotion. Just add the fragrance of the day to your body lotion and you won't clash. Perfume companies charge a lot for their fragranced body lotions and a lot of times they are too strong. You can get the strength you want this way and be sure you like wearing it all over.
9) What happens when you buy a mascara that you just don't like? Sometimes it's not the mascara but it's the wand. Here's a way to get double duty out of mascara wands you really like. When time is up for your mascara toss it but keep the wand. Wash it well and put it aside. You've got it ready now to repurpose it with a different mascara. You won't be able to screw it in so keep the original wand but you'll have a favorite wand to revive a mascara that just wasn't cutting it.
* a clean mascara wand can help separate your lashes before applying mascara. Instead of allowing them to clump together naturally, comb through first.
* is your gray showing at your temples? Add color to the wand and cover it up. A matte eyeshadow that matches your hair color would work for a day.
Which is your favorite hack from this list? Is there a tip you can share?
I look out my window and it's all white. Snow, ice, sleet….every day, day after day. I walk outside and can't even catch my breath because of the subzero temperatures. Inside, it's warm but so dry my skin gets itchy and uncomfortable. I long for the sweet coconut scent of a tropical beach and soft, hydrated skin….and Aveeno comes to rescue!
I've loved Aveeno body products for a very long time because I find the oatmeal-based products extremely gentle and soothing. As an Aveeno Ambassador I was recently sent two coconut-scented Aveeno products to test and I was hoping they would help me satisfy my craving for coconut and for soft skin.
AVEENO® SKIN RELIEF GENTLE SCENT™BODY WASH NOURISHING COCONUT ($7.49) Typically any product that is gentle for skin should probably not include fragrance, but the Skin Relief Gentle Scents products are an exception. In fact, this scented body wash has been clinically tested and is as gentle as the fragrance-free version, which is great news.
The Skin Relief Gentle Scent Body Wash is soap-free, dye-free, and allergy tested. It cleans skin beautifully with a soft lather that rinses clean but doesn't leave my skin feeling dry and tight. And the coconut fragrance….YUM! It's a beautiful scent that isn't overly sweet, it's more like fresh coconuts. Oh so good!! After my shower, the perfect winter combo is following this body wash with….
AVEENO SKIN RELIEF GENTLE SCENT™LOTION NOURISHING COCONUT ($9.99). This is a light lotion with the same coconut scent, also tested and found to be as gentle as the fragrance-free version. The lotion has the ACTIVE NATURALS® Triple Oat Complex, which soothes irritated, dry skin and leaves skin wonderfully hydrated. Anyone with sensitive dry skin will love this non-greasy body lotion. It makes my skin super soft all day long even in dry winter heat. Like the body wash, the scent is a deep, yummy coconut that doesn't have that slightly chemical scent that many lotions have. The scent is faint but still there 12 hours later.
Aveeno is available at Walmart, CVS, Kroger, and other drugstores.
I'm a little late posting about National Healthy Skin Month but it's never too late to try to improve our skin. Aveeno issued a challenge to their bloggers to use their duo of Aveeno Daily Moisturizing Body Wash and Daily Moisturizing Lotion for 3 weeks to remind us about the importance of taking care of our skin during these colder months. As an Aveeno Ambassador I was thrilled to receive these.
My three weeks is almost up but it actually started more than three weeks ago with the Daily Moisturizing Lotion. Now I have one in both bathrooms rather than just one. As many of you know, I prefer fragrance free products so the Aveeno Lotion has been wonderful for me. I've been using it for months. I love how nicely this absorbs and keeps my skin moisturized. Even if I feel like using a fragranced body moisturizer on my lower torso I'll still use my Aveeno Daily Moisturizing Lotion on my upper body.
With the Aveeno Body Wash in the shower even my husband now uses it. It's both gentle and hydrating and it doesn't smell girly so he can enjoy it without making fun of my fetishes.
As we come to the end of October there's still time to get to Target to pick up all the missing Halloween treats, last minute decorations, the costume that your kids decide that they have to have even if they have one already. While you are there I want you to check this end cap with all the J&J products that have been on special this month.
All stores should have this end cap and this week is Aveeno's turn to for an extra discount of 5% off on top of their already low prices. And if you have the Target CC then you'll automatically get your 5% off when you use that.
As an Aveeno Ambassador I've been provided with 5 of their wonderful Positively Radiant products and the opportunity to have 2 Beauty Info Zone readers win a $50 Target gift card. In addition there will be two more winners for the Aveeno Positively Radiant CC Creams – so read on to learn more about some of my favorites from Aveeno.
The entire Aveeno Positively Radiant collection of facial products is formulated to target all 5 Factors of Radiance: tone, texture, dullness, blotchiness, and brown spots. Your skin will look bright and luminous with the use of Positively Radiant.
Let me start by telling you about Positively Radiant Skin Brightening Daily Scrub. This scrub is gentle enough to use daily yet it's totally effective to help improve your skintone, the texture and clarity of your skin. If you want to see some brighter and more radiant skin then this reasonably priced product is one to consider. It combines a moisture-rich soy extract with smooth, round microbeads to gently exfoliate. Even if you skin is sensitive you won't have a problem with this scrub.
Your next step in your beauty routine is Aveeno Positively Radiant Daily Moisturizer with Broad Spectrum with either SPF30 or SPF50. This daytime moisturizer will meet all your needs while being oil-free, hypoallergenic, and noncomedogenic. You have your choice of which sunscreen is best for you with Positively Radiant. It contains ACTIVE NATURALS® Total Soy Complex and natural light diffusers. You'll be radiant all right and at the perfect price.
When you want to color correct the answer is often a tinted moisturizer. Aveeno now has their CC Cream with Broad Spectrum SPF30 available in two shades: Fair to Light and Medium. I didn't swatch these since they are the second place products in our giveaway. My skin is very fair and Fair to Light is a little too dark for me but if I mix it with the Daily Moisturizing Lotion it becomes sheerer and more adaptable. From the colors I've seen online of Medium it's a lot darker and would suit approximately NW/NC25-30 skin and darker. It's very similar to the Daily Moisturizing Cream but with the addition of the tint. Same great ACTIVE NATURALS® Total Soy Complex and natural light diffusers but a product that will give you coverage.
It's the end of the day and it's time to remove your makeup and Aveeno has the answer to that too. They have created a variety of makeup wipes. On the end cap at Target you'll find Aveeno Positively Radiant Makeup Remover Wipes ready to remove all your makeup to reveal softer and smoother skin. Like the other Positively Radiant products this too contains the moisture-rich natural soy extract. Whatever you do be sure you cleanse your face at the end of the day! This is one of the most important steps of keeping your skin in the best shape. When I'm really tired these Makeup Remover Wipes are a necessity. Quick, easy, and efficient.
GIVEAWAY INFORMATION: This is open to US subscribers only. Two first place prizes of a $50 Target Gift Card so that you can go purchase your favorite Aveeno products (and all the other fun things you crave there). Two second place prizes of the CC Creams, one in Fair to Light, one in Medium. This giveaway is open through November 10, 2015 at 11:59 p.m. If comments close you can email me at [email protected] and label it Aveeno, comment in the email and continue on.
These products were provided to me by Aveeno. Thoughts and opinions are my own.
As an Aveeno ambassador I'm lucky enough to receive products from them for testing. The list of what I love from Aveeno is long and it's just gotten a lot longer. Aveeno is used by everyone in my extended family but I've hidden two products from them and don't want to share. ULTRA-CALMING NOURISHING NIGHT CREAM is one I know my husband won't steal from me but DAILY MOISTURIZING LOTION SHEER HYDRATION in this fragrance free version is one he would. But they are mine!!!
I have been using the Aveeno Ultra-Calming Nourishing Night Cream with great success. It's one of the softest, smoothest moisturizers I've ever used. It totally melts into my skin like magic. When I scoop some out I want to slather my entire face and neck with it because it's like applying silk.
But silk doesn't have the great ingredients that this night cream has. Aveeno is known for using ACTIVE NATURALS® Oat and Calming Feverfew® since they are two natural ingredients that are clinically proven for sensitive skin. You may not think you have sensitive skin but if you have irritation and redness then it's more sensitive than you realize. The ACTIVE NATURALS® Oat and Calming Feverfew® nourish your skin leaving it smoother and more hydrated.
At $14.99 this is one of my very favorite Aveeno products and one that will remain in my arsenal – hidden if need be!!
My body needs hydration, especially after playing outside with my little ones and that's where Aveeno's Daily Moisturizing Lotion Sheer Hydration comes in. This fragrance free lotion is another newer product from Aveeno ($6.99-9.99). When this was sent I was in heaven, fragrance free heaven. I've been using their original Daily Moisturizing Lotion but just on my torso. I needed something to keep in my downstairs bathroom to help moisturize during the day and Aveeno must have read my mind. When this arrived it came with a small packet of tissues to do a hand test. They wanted to prove how quickly it absorbs. I applied it and instantly used one of the tissues and no particles stuck to my hands.
My hands feel moisturized and stay that way. While Aveeno says it moisturizes for 24 hours, I wash my hands dozens of times a day so I like to apply it often. If I apply it before bed that's when I see the long lasting effect. Since there's no fragrance it doesn't interfere with anything I've used day or night.


This could be the only web page dedicated to explaining the meaning of MWM (MWM acronym/abbreviation/slang word).
Ever wondered what MWM means? Or any of the other 9127 slang words, abbreviations and acronyms listed here at Internet Slang? Your resource for web acronyms, web abbreviations and netspeak.
MWM is "Married White Male"
The definition of MWM is "Married White Male"
MWM means "Married White Male"
So now you know - MWM means "Married White Male" - don't thank us. YW!
What does MWM mean? MWM is an acronym, abbreviation or slang word that is explained above where the MWM definition is given.


As the algae and moss forms over some of the lakes and the frogs are prevalent use weedless plastic frogs or frog type lures over the top of the moss beds. The Largemouth are sitting under these areas and praying on the frogs as the hop across the top of the moss.
Lines on the moss where I was hopping the frog.
You can catch bullfrogs with them too. I think we have caught 5 this year.
That`s funny about the bullfrogs.
Sad thing was getting the hooks out of their mouth, kind of tore them up a bit.
Please promote "Using Frog Lures Late Summer"


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Q: Spring jpa column defaultvalue I'm trying to do the following
@ManyToOne
@JoinColumn(name="tier_id", columnDefinition = "INT default 1", nullable = false)
public Tier getTier() {
    return tier;
}

but while inserting the record I get
com.mysql.jdbc.exceptions.jdbc4.MySQLIntegrityConstraintViolationException: Column 'tier_id' cannot be null
I want default tier_id to be 1 if it's not set, but it's not working. How can I correctly set this up?

A: The default SQL value is only used if the column is not present at all in the insert statement.
But Hibernate doesn't omit columns in insert statements. If you create an entity instance with a null tier, and persist it, you're effectively saying Hibernate that you want to persist an entity with a null tier, and Hibernate explicitely sets the tier_id column to null, since that's what you told it to do.
So, if you want your entity's tier to be the tier with ID 1, then do it explicitely in your application code:
SomeEntity e = new SomeEntity();
e.setTier(em.getReference(Tier.class, 1));
em.persist(e);

redpajama_set_name: RedPajamaStackExchange


Amanda and Luke had every fine detail of their wedding day covered and organised…from personalised bridal party boxes, personalised gifts, personalised socks and even a photo of her and her dad on her dads tie. Every detail was thoroughly thought of and it was awesome seeing all the planning coming together on the day and seeing their dream wedding day become a reality.
Luke is a fireman, so of course I had to use a smoke bomb in the evening for a few photos on this gorgeous wedding day!
This entry was posted in aipp, Bayside Wedding Photographer, destination wedding, Melbourne wedding photography, Mornington Peninsula Wedding Photographer, Mornington Peninsula Wedding Photography, portsea wedding, Wedding Photography and tagged Mornington Peninsula Wedding Photographer, Night wedding photography, Portsea Hotel Wedding, portsea wedding.


Awarded the Dispelling the Myth Award in 2011, Baylor-Woodson's district, Inkster, was subsequently dissolved because the state considered it financially unstable.
Almost within sight of the Detroit Airport, Baylor-Woodson Elementary School's small district of Inkster was always financially stressed. It welcomed the per-pupil allotment that came with cross-district enrollment, which made it a magnet for families in next-door Detroit. As a result, it almost doubled the number of students it enrolled over the course of a few years, 85 percent of whom qualified for free or reduced-priced meals.
Baylor-Woodson Elementary School, the district's grade 3 through 5 school, consistently posted high proficiency rates, with just about all its students — most of whom were African American — meeting reading and math standards. In fact, 73 percent of its fifth-graders scored as advanced in math in 2011, compared with 45 percent in the state. Reading proficiency rates were almost as strong, with 63 percent scored as advanced in reading compared with 44 percent statewide.
"We're not perfect, but we work together" is how fifth-grade teacher Nelson A. Henry put it.
In June 2013, the Michigan legislature enacted a law, signed by the governor, that was closely tailored to permit the closing of two of the more than 50 districts in the state that were in fiscal distress, including Inkster, and the responsible agency, Wayne County Regional Educational Services Agency, subsequently dissolved the district of Inkster, although it publicly questioned the need.
Baylor-Woodson no longer exists as a school. Staff members were fired and the students dispersed to other, neighboring districts.
The experience of Baylor-Woodson is a reminder that schools exist within larger contexts that sometimes undermine even highly functional schools.
Inkster district was dissolved by the region under orders from the state superintendent for fiscal instability.
A statement by the Wayne County Regional Educational Services Agency explains the dissolution of the district.
An Education Week story explores the dissolution of the district.


GEORGE TOWN: The developer of a high-rise project in Kelawei Road here has been slapped with a two-week stop-work order after mosquitoes were found to be breeding at the construction site.
After fining the developer RM500 for the offence, the Penang Municipal Council (MPPP) yesterday gave it a fortnight to comply with all requirements, including removing all present and potential breeding grounds and to come up with specific steps to prevent any recurrence.
MPPP Building Department director Yew Tung Seang said the council and state Health Department conducted inspections following complaints from residents of neighbouring Solok Concordia after two occupants of a house there came down with dengue recently.
Some residents of Solok Concordia met Bukit Bendera MP Zairil Khir Johari at the house of Poh Yang Heang yesterday to complain about mosquitoes from the construction site. Poh, whose mother and wife came down with dengue, said the residents made numerous complaints to MPPP about the mosquitoes for the past three months, but their complaints fell on deaf ears.
Poh, 34, said there was a surge in the number of mosquitoes in the area when work began on the construction site a year ago. He claimed that foreign workers there threw rubbish and empty cans into a gap barely half a metre wide separating his house and the fenced-up site.
He said the place was almost impossible to be cleaned as no one could enter the narrow path. As a result, Poh said he had to cover his entire house with mosquito netting and bought various types of mosquito repellents, sprays and coils.
"Developers should be responsible for the cleanliness of their sites. They should educate their workers on keeping the surroundings clean as most of these sites are in residential areas," he said.
A spokesman for the developer said it was surprised there were mosquitoes as its workers carry out a weekly housekeeping, while regular fogging was also conducted.


In line with their continued expansion, our client, a prestigious professional translation service with state of the art offices and facilities, has a superb opportunitiy for a translation checker with native Italian and fluent degree level English.
You will join an international team of checkers who proofread technical translations prepared by in-house staff and external sources. You will also be involved in updating existing translations to correspond to newer versions, and will assist in some general admin and despatch duties.
This is an ideal opportunity for progression to trainee translator status, when further study will be encouraged to develop full Translator status or other senior role within the organisation.
Starting salary £23,500 plus excellent benefits.


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Q: Installing the Android-Studio GPU debugging tools I tried following the manual to install the Android GPU debugging tools for android Studio 2.0. Unfortunately it has not been very successful.
I have been following the instructions of the official documentation which are still for version 1 of the gpu debugging tools here: http://tools.android.com/tech-docs/gpu-profiler
It also isn't that helpful otherwise.
I am using an arm based emulator for testing since the abi specific folders specified in the manual are for arm abi's only.
Also the red button above the gpu monitor that is used to start the debugging tools is grayed out for me and it tells me that the gpu debugging tools are not installed when I hover over it.
Are there any extra steps I need to follow to get it to work?


Solo 401(k)s have become a popular retirement plan option for self-employed persons. Unfortunately, many of the plans are not properly maintained and are at the risk of significant penalty and/or plan termination. If you have a Solo 401(k), you need to ensure that the 401(k) is being properly maintained. Here's a quick checklist to make sure your plan is on track.
Is the Plan Up-to-Date? The IRS requires all 401(k) plans, including solo 401(k)s, to be amended at least once every 6 years. If you've had your plan over 6 years and you've never restated the plan or adopted amendments, it is not compliant and upon audit you will be subject to fines and possible plan termination (IRS Rev Proc 2016-17). If your plan is out of date, your best option is to restate your plan to make sure it is compliant with current law. On average, most plan documents we see update every 2-3 years as the laws effecting the plan documents change.
Are You Properly Tracking Your Plan Funds? Your solo 401(k) plan funds need to be properly tracked and they must identify the different sources for each participant. For example, if two spouses are contributing Roth 401(k) employee contributions and the company is matching traditional 401(k) dollars, then you need to be tracking these four different sources of funds, and you must have a written accounting record documenting these different fund types.
Plan Funds Must Be Separated by Source and Participant. You must maintain separate bank accounts for the different participants' funds (e.g. spouses or partners in a solo K), and you must also separate traditional funds from Roth funds. In addition, you must properly track and document investments from these different fund sources so that returns to the solo 401(k) are properly credited to the proper investing account.
Does Your Solo 401(k) Need to File a Form 5500? There are two primary situations where you may be required to file a Form 5500 for your solo 401(k). First, if your solo 401(k) has more than $250,000 in assets. And second, if the solo 401(k) plan is terminated (regardless of total asset amount). If either of these instances occur, then the solo 401(k) must file a Form 5500 to the IRS annually. Form 5500 is due by July 31 of each year for the prior year's plan activity. Solo 401(k)s can file what is known as a 5500-EZ. The 5500-EZ is a shortened version of the standard Form 5500. Unfortunately, the Form 5500-EZ cannot be filed electronically and must be filed by mail. Solo 401(k) owners have the option of filing a Form 5500-SF on-line through the DOL. The on-line filing is a preferred method as it can immediately be filed and tracked by the plan owner. In fact, if you qualify to file a 5500-EZ, the IRS/DOL allow you file the Form 5500-SF on-line but you can skip certain questions so that you only end up answering what is on the shorter Form 5500-EZ.
Are You Properly Reporting Contributions and Rollovers? If you've rolled over funds from an IRA or other 401(k) to your solo 401(k), you should've indicated that the rollover or transfer was to another retirement account. So long as you did this, the company rolling over the funds will issue a 1099-R to you, but will include a code on the 1099-R (code G in box 7) indicating that the funds were transferred to another retirement account, and that the amount on the 1099-R is not subject to tax. If you're making new contributions to the solo 401(k), those contributions should be properly tracked on your personal and business tax returns. If you are an s-corp, your employee contributions should show up on your W-2, and your employer contributions will show up on line 17 of your 1120S s-corp tax return. If you are a sole prop, your contributions will typically show up on your personal 1040 on line 28.
Make sure you are complying with these rules on an annual basis. If your solo 401(k) retirement plan is out of compliance, get with your attorney or CPA immediately to make sure it is up-to-date. Failure to properly file Form 5500 runs at a rate of $25 a day up to a maximum penalty of $15,000 per return not properly filed. You don't want to get stung by that penalty for failing to file a relatively simple form. The good news is there are correction programs offered for some plan failures, but don't get sloppy, or you'll run the risk losing your hard-earned retirement dollars.


If you don't find a garage, youtube and forums are your friend. Changing pads/rotors and bleeding brakes is something you can do with barely any tools. If you can read and play with legos, you can probably do it yourself.


The village of Schaumburg is in Cook County in the northeast part of Illinois state. It is suburb of Chicago and part of the area around the I-90 called the Golden Corridor. It is about 28 miles from the Chicago Loop on the northwest side and 10 miles from O'Hare International Airport. As a village, Schaumburg is pretty big, with a total area of 19,333 square miles, has the 11th largest mall in the US, and one of only two IKEA stores in Illinois.
It wasn't always so developed, however, The transition of Schaumburg from rural area to suburban metropolis is actually quite interesting. In the beginning, the area was occupied for the longest time by different Native American tribes including the Potawatomi Sauk, Fox, and Kickapoo. Americans from the East and German immigrants only began to arrive in the mid-1800s.
Legend has it that among the first settlers were Americans Trumball Kent, Ernst Schween, and Horace Williams, as well as Johann Sunderlage, a German surveyor who like the place so much he brought his family over from Germany in 1836. At one point, most of the Schaumburg properties were owned by German immigrants and their families as most Americans that had initially settled in the area moved farther west to the Great Plaines. By 1870, the town was as German as any town in Germany, and continued to be so until the 1930s when the Great Depression resulted in foreclosure of some German-owned farms, which were subsequently bought by non-Germans.
The town's name was declare during a town meeting in 1850. This was when one of the landowners Friedrich Henrich Nerge said that it will be Schaumburg. However, it wasn't until 1956 that it became an incorporated village, a year after construction began on the O'Hare International Airport.Three years later, the first of large scale developments in the area was begun by Alfred Campanelli. The Woodfield Mall opened in 1971 as more of the neighboring area was annexed to make room for the many manufacturing, industrial, and retail establishments that sprang up in the area. This expansion essentially changed the village from a quiet rural community to an urban environment.
The population growth of Schaumburg has slowed down somewhat as land became scarcer, and as of 2014 had 74,896 residents. Of that, 60.5% are white, 23.4% are Asian, 10.4% are Hispanic, and 1.8% are African American. The median household income as of 2015 is $73,537, appreciably more than the state median at $59,588.
Several people of note are in connection with Schaumburg. One of them is Bob Atcher of "You are My Sunshine" fame, who served as village president for a time, stepping down in 1975. The wife of Robert Downey Jr., Susan Downey, attended Schaumburg High School, graduating with top honors in 1991. Actress Jessica Lu and pro ice hockey player Zach Cohen were born here, while professional MMA fighter Jason Guida does so from Schaumburg.
The St. Peter Lutheran Church was up in 1847 and is the oldest in Schaumburg, currently still up as a museum. Back in the day until 1970, the services were in German, the first language of many of the residents. Former Illinois Lieutenant Governor Francis Hoffman used to hold religious meetings there.
You might also want to go to the Prairie Center for the Arts and catch a performance or imbibe the local culture at the Farmer's Market from June to October. Go back even further and check out the Native American owned and operated Trickster Art Gallery.
Go back to nature by going to the Schaumburg Park District, where you can seek some peace and quiet at the Spring Valley Nature Center, an outdoor living museum.
The clients had inherited a charming 3-bedroom ranch house in Schaumburg built in 1967, and was making plans to move there from Wisconsin. It was very traditionall design, which was exactly how the client wants. However, the kitchen cabinets were not in good condition, and they were quite small, so the client wanted them all replaced. She contacted us for a quote on new cabinets.
We went over to take measurements and look at the existing design so we could advise the client about what we can do and how much it would cost. She wanted the new cabinets to be in keeping with the rest of the house but with a lot of storage. With hardwood floors and furniture, white walls, and red brick, the best cabinet color would be white. We recommended 42 inch shaker style cabinets with crown molding. Also we gave her a quote for Schrock cabinets, and she put down a deposit. We advised her that delivery would be in two to three weeks.
We were able to deliver the cabinets to the client on schedule. We followed up after two weeks to find out if there were any problems. In addition we saw that installation had gone without a hitch. We asked the client for photos of the installed cabinets. And we were very happy to see that it did look as good in the kitchen as we anticipated. The client was very thankful to us for the advice and she was very happy with the product.
We carry various lines of high-quality cabinets in the US for all tastes and budgets, so you are sure to get what you need from us. Aside from Schrock, we also carry Wolf Classic, J&K Cabinetry, Fabuwood, Echelon, and Forevermark. We can also accommodate custom cabinets if you need them. Contact us now for quality cabinets in a flash.


Bunka no Hi at the JCCCW in 2017. Photo by Jason Go.
An exhibit on Seattle's old Nihonmachi during Bunka no Hi 2017. Photo by Jason Go.
Koto demonstrations during Bunka no Hi 2017. Photo by Jason Go.
Karate demonstrations during Bunka no Hi 2017. Photo by Jason Go.
Tea ceremony demonstration during Bunka no Hi 2017. Photo by Jason Go.
Scroll below for full schedule.
Bunka no Hi is a celebration of Japanese and Japanese American culture and heritage. A popular annual event hosted by the JCCCW, the schedule is filled with performances, cultural demonstrations, games, and other activities. It is a true community-wide event, with booths and informational displays from a variety of local groups, nonprofit organizations and a couple of vendors. No matter where your interests lie, Bunka no Hi will have something for everyone! This is a free event!
This year the 'J' is proud to present two exhibits during Bunka no Hi. "Travel to Japan" will offer useful travel tips for those hoping to explore the Land of the Rising Sun, especially with the 2020 Olympics in Tokyo right around the corner. An additional exhibit will focus on "Nisei Daughter," an autobiography by Monica Sone, a Seattle-born Japanese American.
Northwest Nikkei Museum Permanent exhibits: Unsettled/Resettled: Seattle's Hunt Hostel, Genji Mihara: An Issei Pioneer All day 終日 No なし Unsettled /Resettled: Seattle's Hunt Hotel Resettling of the Japanese community in Seattle after their return from incarceration camps. 戦後、強制収容所から解放された日系人がシアトルに戻り、どのように生活を再開したかについての歴史的展示. An Issei Pioneer, JCCCW's feature exhibit on the life of Issei (first-generation Japanese immigrant) leader Genji Mihara. 日系社会のリーダーとして活躍した一世、三原源治氏の生涯を紹介する展示.


I crossed over to Yuen Long in the New Territories of Hong Kong last weekend. My first time there and to my surprise, the whole place is a town on its own! There are so many good places to eat, so many places to shop, karaoke is so cheap (clean ones of course), so many places to eat (oops I said that already) and so crowded!
After alighting from the bus from the causeway, we walked a little to reach this bird will not lay eggs place (鸟不生蛋的地方), which if I was left alone, I will never find it and prolly get lost in the process. It's located somewhere near B仔凉粉, so if you can find it, just ask the people there. The restaurant is a very small outlet which claims to sit 64 people… Seriously, to me, I think half of that would be comfortable. You know lah, in HK, everything is small… flats are small, offices are small, hotel rooms are small, even eateries are small! So we went in and found a good seat under the aircon. 🙂 To my surprise, the whole place was so crowded until left only a table for us… it was 3pm+! I heard Hong Kongers eat throughout the day… it's so damn true man! I love HK!!! Woot! So we started ordering what we can possibly finish.
Huge Volcano Rolls... the menu has got a lot of selection!
Their super long sushis... this is how they made a name for themselves! Prices seen here are in HKD.
First up, Salmon Sashimi. Super thick slices of about 1cm!!! Super fresh and it just melts in your mouth! For only HKD$45!
Have u seen... ok nevermind, I'll just eat... HKD$12 only... wah worth it!
Baked Rice with Tofu, Chicken & Cheese (HKD$38). This is prolly the worst dish there. they should take this out. Got chef's recommendation some more... Tasteless and not enough ingredients.
Taste: Very fresh and very nice. Very different from what we get in Singapore. Love it!
Portion: Above average. they really live up to their mission. Good portion, good quality, good service and good prices. Excellent job Becky!
Price: Total bill about HKD$400+, which works out to be about SGD$70+. Totally worth it for the portions.
Location: Yuen Long @ 教育路裕榮徑好旺大廈13-14號舖 TEL: 24494433. This is the flagship outlet since the year 2003. Can't find, call them.


text:
La médaille d'or Catherine Wolfe Bruce, ou médaille Bruce () est un prix scientifique attribué annuellement depuis 1898 par la Société astronomique du Pacifique (ASP), fondée à San Francisco en 1889. Elle récompense une personne pour l'ensemble de ses travaux dans le domaine de l'astronomie. Elle doit son nom à Catherine Wolfe Bruce, bienfaitrice américaine qui a contribué à financer de nombreux projets en astronomie à la fin du .

Les candidats nominés sont proposés par les directeurs de six observatoires astronomiques, trois américains et trois d'autres pays, les observatoires impliqués changeant régulièrement. Le prix est ouvert « à des ressortissants de tout pays et des deux sexes », et attribué annuellement, le bureau de l'ASP se réservant le droit de ne pas l'attribuer les années où les candidats qui lui sont proposés ne le satisfont pas.

Liste des récipiendaires

Notes et références

Liens externes

  (avec liste des récipiendaires)
  Liste des observatoires ayant participé à la nomination des candidats
  A Brief History of the Bruce Medal of the A.S.P., Joseph S. Tenn, Mercury 15, 4, 103 (1986)
  Centennial History of the Astronomical Society of the Pacific, Chapter 7, the Bruce Medal, Katherine Bracher, Mercury 18, 5, 3 (1989)
  Seventy-Five Years of the Astronomical Society of the Pacific, H. Joy, PASP 77, 81-88A (1965)

Bruce

Distinction fondée en 1898

redpajama_set_name: RedPajamaWikipedia