? DESCRIPTION (provided by applicant): Chronic nonvalvular Atrial fibrillation (AF) is a very common and costly public health problem. AF may reduce the quality and duration of life, both, particularly by increasing the risk of devastating thromboembolic strokes. Anticoagulants, including vitamin K antagonists (VKAs, e.g., warfarin) and non-VKA anticoagulants (NOACs, e.g., dabigatran, -xabans), are very effective, but underused treatments. Anticoagulation underuse results form challenges clinicians face in prescribing these drugs and patients face in implementing their use in their lives. Recognizing these challenges, leading cardiovascular societies in 2014 formulated a class I recommendation of shared decision making (SDM) for the individualization of anticoagulation therapy in at-risk patients with AF. However, there are no proven interventions to support the implementation of this recommendation, and no evidence of the effect of SDM on the problem of initiating and implementing anticoagulation. With over a decade of experience, we have demonstrated the practical impact of SDM interventions in other contexts. Building on this experience, we propose to use an SDM tool we developed using user-centered design, ANTICOAGULATION CHOICE, to promote SDM about anticoagulation between patients with AF and their clinicians. Using a randomized trial design, we plan to determine the impact of using this tool on the quality of SDM and on the rate of anticoagulation and patient adherence to this therapy. By generating reliable practice-based evidence, this trial can provide feedback to the guideline panel about the impact of SDM on the quality of individualized anticoagulation care. We propose to enroll 999 adult patients with chronic nonvalvular AF deemed at high risk of thromboembolic strokes (CHA2DS2-VASc score ? 1, or 2 in women) and receiving care in academic, community, or safety net clinics. We plan to randomly assign them to care with or without a new SDM tool, ANTICOAGULATION CHOICE. Trial outcomes include the quality of SDM (primary endpoint, aim 1), the rate of anticoagulation, the distribution of anticoagulants chosen, and patient adherence to anticoagulation at 12 months (aim 2). If successful, this work will reduce the underuse of anticoagulation therapy and improve the care and outcomes of millions of patients with AF.


A CT scan of a mesothelioma tumor in the lining of the lung. The tumor is the top section outlined in blue.
Mesothelioma, an aggressive cancer that usually occurs in the chest wall, has historically been difficult to treat. Now research from Memorial Sloan Kettering suggests how mutations found in these tumors may be targeted with drugs.
More than half of mesothelioma tumors have mutations in the gene BAP1.
A new study has shown how BAP1 mutations lead to tumor growth.
Drugs already in trials for other cancers may benefit patients with mesothelioma.
MSK investigators are now planning trials to study these drugs in mesothelioma patients.
Mesothelioma, a cancer that usually occurs in the lining of the lung, is largely associated with exposure to asbestos, a building material widely used until the 1970s. The disease is aggressive and has historically been very difficult to treat. Now research conducted at Memorial Sloan Kettering has led to an approach that could benefit about half of all mesothelioma patients.
The cancer has been linked to both inherited and acquired mutations in a gene called BAP1. Discovered in 2011 by MSK experimental pathologist Marc Ladanyi, BAP1 mutations are also associated with inherited forms of uveal melanoma, a rare eye cancer, and a type of kidney cancer called clear cell renal cell carcinoma. Although only a small number of people with mesothelioma carry BAP1 mutations in their germline (meaning that they inherited it from their parents), Dr. Ladanyi found that 50 to 60 percent of all mesothelioma tumors have BAP1 mutations, making BAP1 a promising target for drug therapy.
More than half of all mesothelioma tumors have BAP1 mutations.
Research in mice has shown how BAP1 mutations lead to cancer.
In a new study, published recently in Nature Medicine, a team led by MSK physician-scientist Ross Levine created a mouse with a mutated form of BAP1. They found that when BAP1 was knocked out or inactivated due to mutations, the levels of an enzyme called EZH2 went up, allowing mesothelioma cells to grow out of control. The investigators then showed in mouse models and in mesothelioma cells that blocking EZH2 could inhibit the growth of these tumors.
The drugs that block EZH2 are among a new class of drugs that target the epigenetic changes in cancer cells. Epigenetics is a growing field that's based on the study of genetic changes that are not part of the DNA code. In this case, the drugs target changes in histones, the proteins that DNA strands wrap around in the nucleus of the cell and that determine which genes are available to instruct the manufacture of proteins.
"When BAP1 is knocked out and EZH2 levels goes up, it leads to inappropriate modification of a particular histone, which is the mechanism by which cells are able to proliferate out of control," says physician-scientist Scott Armstrong, head of MSK's Center for Epigenetics Research and one of the study's co-authors.
The investigators are now interested in extending their laboratory observations to the clinic and are working in coordination with the biotechnology firm Epizyme to study EZH2 inhibitors in mesothelioma patients.
Collaborative research among several MSK departments has led to the findings.
This research was funded by the Pershing Square Sohn Prize awarded to Dr. Levine and by the National Cancer Institute under grants R01GM096056, CA172636, and F31 CA180642-02.
I am concerned about my own health. I have been having severe pain on my left side and doctors have not been able to figure it out. My father just died last year at age 59 from Mesothelioma. We found out in August that he had Cancer when he went in for a hole in the bowel. He was debulked and had no further treatment. He died October 27th. He had started with some kidney issues in April...doctors weren't really sure but they did diagnosis him with an unknown protein in his urine. This caused a few trip in and out of the hospital in April-June. He was exposed to asbestos from his Father and also as part of his own work. We grew up in Conemaugh, PA which is near the Steel mills.
Should I be concerned at this point?
Holly, we are very sorry for the loss of your father. We recommend that you discuss your concerns with your healthcare team. Thank you for your comment.
Do you known if any targeted medication that could treat SICKLE CELL ANEMIA has been studied?
Lore, MSK is primarily a cancer center and sickle cell anemia is not generally a disease that we treat. For more information on the latest treatments, we recommend you refer to the National Institutes of Health at https://www.nlm.nih.gov/medlineplus/sicklecellanemia.html or the Sickle Cell Disease Association of America at http://www.sicklecelldisease.org/. Thank you for your comment.


Yorebridge House is situated by the river on the edge of Bainbridge, in the heart of the North Yorkshire Dales. In the Victorian era this was a schoolmaster's house and school; the building now offers luxury boutique-style accommodation. Each bedroom is individually designed with high-quality furnishings and thoughtful extras. All rooms have stunning views of the Dales and some have their own terrace with hot tub. There is a comfortable lounge bar where guests can relax before enjoying an excellent, three AA Rosette award-winning dinner in the attractive and elegant dining room.
A648 to Bainbridge. Yorebridge House north of centre on right before river.


text:
Stolen Ruby Slippers Worn by Judy Garland in 'The Wizard of Oz' Recovered 13 Years Later
3:06 PM PDT, September 4, 2018 - Inside Edition Staff
Playing Stolen 'Wizard of Oz' Ruby Slippers Returned 13 Years Later
The ruby slippers worn by Judy Garland in "The Wizard of Oz" have been recovered, more than a decade after they were stolen.
The shoes were stolen from a glass case in The Judy Garland Museum in her hometown of Grand Rapids, Minnesota, in August 2005.
The iconic shoes were insured for a million dollars when they vanished.
In 2015, 10 years after the theft, a movie buff offered a reward of a million dollars for the return of the stolen slippers, but their whereabouts remained a mystery until Monday.
At a news conference Tuesday afternoon, the FBI revealed how they were recovered.
"We received a new tip and some information we diligently pursued — lots of interviews, searches — only to later lead this summer to the recovery of these slippers," FBI Special Agent Jill Sanborn said at the press conference.
Following the news conference, the FBI tweeted about finding the slippers.
A pair of ruby slippers worn by Judy Garland in the 1939 film The Wizard of Oz, and stolen from the actress' namesake museum in Minnesota more than a decade ago, has been recovered: https://t.co/5HsUe163VF pic.twitter.com/edKUFiwWpf
— FBI (@FBI) September 4, 2018
Michael Shaw is the private collector who had loaned the shoes to the museum when they were stolen. He told Inside Edition he started crying when they were found.
"I just was thrilled," he said. "Absolutely thrilled. I know it sounds ridiculous but I started to cry. I never thought that I would hear that they were still in existence."
The shoes are one of several pairs Garland wore while shooting the 1939 movie.
Another pair is due to be put on display at The Academy Museum of Motion Pictures when it opens next year in Los Angeles. Those shoes were jointly acquired by Leonardo DiCaprio and Steven Spielberg for the museum.
A third pair is at the Smithsonian, while a fourth is owned by a private collector.
It's believed the recovered shoes could fetch as much as $5 million at auction.
Celebrities We Lost in 2018: See the Photos
The Real Story Behind 'Winnie-the-Pooh' as 'Christopher Robin' Movie Hits Theaters
What Is the Winchester Mystery House? A Look at the Home That Inspired a Horror Movie
The Truth Behind Megalodon Sharks That Inspire 'The Meg' Movie

redpajama_set_name: RedPajamaCommonCrawl


It's Open Access week around the globe. Open access is different from Open Educational Resources in that it focuses on increasing access to research and scholarly publications. The University of Texas Libraries will be organizing numerous events to bring awareness to this important topic.


We have some really exciting news too.
Janice, from Scrapper's Delights, designed some fabulous vintage digital stamp, especially for our design team to use for this challenge. And what's more, from today you will be able purchase them from their store, Scrappers Delights store.
Yet again, our Design Team have made some wonderful inspiration.
Remember, you don't have to make a card to enter. Any craft will do!!!
Muslin Diary bag - Image was transferred on to material.


The Duchenne Research Fund recently shared the news that we are supporting the KineDMD study – Dr Aldo Faisal's ground-breaking artificial intelligence study at Imperial College London, in collaboration with Great Ormond Street Hospital, which aims to accelerate Duchenne muscular dystrophy research and clinical trials.
Boys and young men will wear non-intrusive sensors at home to enable clinicians to monitor their activity 24/7 and gather more accurate data about their movements and mobility. They will also wear an AI bodysuit a few times in the clinic to evaluate their progress. It is projected that monitoring patients' progression with sensors and using Dr Faisal's unique algorithmic analysis could reduce the timescale of future clinical trials by up to 50%. This would save enormous costs and clinical resources and may be able to much more quickly evaluate whether a new drug or treatment being trialled is effective for the patient.
Click here to read more about this project in our projects section.
Click here to read more about the research on the Imperial College London website.


text:
NACCHO Aboriginal Health News Alerts
The national authority in Aboriginal primary health care – Aboriginal health in Aboriginal hands
NACCHO
Welcome & Intro
← NACCHO Aboriginal health Monday snapshot: 19 August 2013
NACCHO $70,000 community awards : The Australian Innovation Challenge →
NACCHO health news: Fiona Stanley: the secret to improving Aboriginal healthcare
"Who knows and cares most about Aboriginal health? We do. So give us the funding and the knowledge and partner with us to enable us to be responsible for our own health and wellbeing."
Ted Wilkes
When Noel Pearson launched The Quiet Revolution, the book of Marcia Langton's 2012 ABC Boyer Lectures, he had the audience in the palm of his hand for almost an hour.
Pearson spoke quietly and clearly about pathways to being "bourgeois", as he called himself. "Why can't Australians be proud of us being middle class? Why can't non-Aboriginal folk in Australia support us in our quest to be part of an elite, to own our own homes and participate in the Australian economic and social fabric?" he asked.
This is an edited extract from essay "On the ground: Key to successful policy outcomes" in GriffithREVIEW 41, available now.
Extract from the Griffith Review Via Crikey
It was a great talk that explored the creation of an Aboriginal and Torres Strait Islander middle class. Even if you heard the lectures, read the essays — the power of the words on the page put paid to the simplistic criticism that they were just a defence of the mining industry. This is a part of a much bigger project, a transformation, that for the first time means First Nations people are being trained and employed in all areas of the Australian workforce. And doing so in ways that retain and share their culture with others.
Both Noel Pearson and Marcia Langton are unapologetically part of the Aboriginal elite. Like W.E.B. Du Bois in the US a century ago, their cool analysis and forthright advocacy discomforts those with a rusted frame for thinking about First Nations people, one that consigns them to intergenerational underachievement.
Du Bois believed that the top 10% of any culture or population group is the vanguard that brings others along and around them. Born in 1868, three years after the end of the American Civil War, Du Bois was the first African-American to receive a doctorate from Harvard (and also later from Berlin) and one of America's first sociologists to use large social surveys to examine the circumstances of people living in disadvantaged urban areas. His idea of the "talented tenth" was based on the notion that groups like the African-American population needed leaders with the very best education (his doctorate was in classics, philosophy and science) and this leadership would propel the success.
He established the National Association for the Advancement of Colored People in America, but left his homeland as a result of the Joseph McCarthy witch-hunts and died, at 95, in Ghana, a few days before Martin Luther King Jr gave his "I have a dream" speech. He was enormously influential in fighting for full civil rights in America but earned the enmity of radicals who favoured more direct action.
Langton's essays are as bold, and potentially transformative, as Du Bois' writings were a century ago. She writes:
"Indigenous participation in education systems and the economy are the main pathways out of the miserable conditions that produce ongoing disadvantage and reduce Aboriginal capacity to enjoy their rights as first Australians and citizens of one of the richest nations on earth."
Well, they could be transformative if non-Aboriginal Australians really heard the messages on these issues. As she writes:
"The majority of Australians have remained ignorant of the reasons for the high levels of disadvantage that Indigenous people face, both because the reasons are complex, and because there is a wealth of misinformation as well as irrational belief about Aboriginal people in circulation."
Langton is not party political, and she believes that these issues should not be politically divisive and "the truth is always much more complicated than the policy positions of governments, parties and campaign offices would have us believe".
At the Telethon Institute for Child Health Research we made a commitment to employing and training as many First Nations researchers as we could, with the aim of giving the Aboriginal research agenda to them. Well-respected, nationally recognised elder Ted Wilkes put it simply:
It was clear he understood the social determinants of health better than anyone, so we concentrated on changing the culture within the institute to enable Aboriginal leadership to grow.
"Engaging Aboriginal people in the development of programs and methods results in them getting exactly the services they need, in their environments and for their unique circumstances."
Sandra Eades joined the Institute as a PhD student in the mid-1990s, where she became one of the first First Nations people to secure a National Health and Medical Research Council (NHMRC) grant as leading chief investigator. She employed an outstanding group of Aboriginal health workers as research assistants to conduct a longitudinal study of first-time Aboriginal mums and their babies in urban Perth. This group of researchers proved Wilkes' approach.
The study successfully enrolled the mothers, and the institute was able to follow their babies in ways that would not otherwise have been possible. It was a true partnership between those with different types of knowledge. Its success convinced the institute that employing and training First Nations researchers and using their methods was essential for the success of the research agenda.
All these health workers-turned-researchers had been trained by another pioneering First Nations Westen Australian health professional, Dr Joan Winch, who set up Marr Mooditj, the first Aboriginal health worker training program in Australia.
Eades had a huge influence on the NHMRC with her roadmap for supporting Aboriginal health research. One brilliant idea from that and other public health strategic planning was Capacity Building Grants to redress this neglected area. In 2005, the Institute won the first such grant in Aboriginal health, with a team of 10 Aboriginal investigators: Michael Wright, Ted Wilkes, Helen Milroy, Sandra Eades, Ngiare Brown, Juli Coffin, Dawn Bessarab, Jan Hammill, Cheryl Kickett-Tucker and Glenn Pearson.
Over the five years of the grant most completed their PhDs and all have become leaders. A group of them, plus Pat Dudgeon and Rhonda Marriott, formed the group of eight chief investigators who subsequently secured NHMRC support for a Centre of Research Excellence in Aboriginal Health and Wellbeing: From Marginalised to Empowered.
I recall helping to write this grant only to have it totally rewritten by the Aboriginal chief investigators. They were committed to a different paradigm of research methodology than mine. They wanted to conduct their own research projects with full engagement with Aboriginal community groups, shifting the power for participation at every stage — from the planning through to data collection, interpretation and implementation. I had instead written a good NHMRC quantitative application hoping that once we got the grant we could incorporate these more qualitative approaches.
I warned that NHMRC was not ready for such a radical proposal. I was wrong. The whoops of joy when they succeeded raised the roof.
There are two major changes in this approach — the first is to truly engage with the people who are the intended recipients of the services that are needed. This demands familiarity with a well-developed, internationally accepted set of methods known as 'community participation action research'. There are well-established ways to do this, which have been used with the "Untouchables" (Dalits) in India and the First Nations in Nunavut (Canada). As a result, service delivery has been revolutionised.
It is not rocket science, but grounded in a self-evident truth: most of us only use the services we trust, that we feel we have some control over and that benefit our families and ourselves.
Aboriginal people in this country have little experience of exercising such a fundamental power over the services deemed appropriate for them. For many decades these services have been shaped by distant experts who thought they knew best.
Engaging Aboriginal people in the development of programs and methods results in them getting exactly the services they need, in their environments and for their unique circumstances. It also provides jobs, an additional advantage to them, which adds to the efficacy of the services. Aboriginal people will travel across the metropolitan area to attend an Aboriginal-controlled service.
This means that while the overarching principles of services can be developed centrally by government agencies — for example, early childhood learning is good for children to be ready for school, or complete vaccination prevents childhood infections, or sugary foods and drinks should be avoided to prevent type 2 diabetes — the way that these services are implemented should be done in collaboration with those who will be affected, the people themselves. Otherwise they simply do not work.
NACCHO NASTIHP health plan news: Racism a driver of Aboriginal ill health (nacchocommunique.com)
NACCHO NATSIHP news: $12 billion Aboriginal health plan to be launched today (nacchocommunique.com)
NACCHO NATSIHP News:What a report about Aboriginal health can teach journalism (nacchocommunique.com)
NACCHO Researching Right Way workshops: Shaping good Aboriginal health research practices (nacchocommunique.com)
NACCHO download and updated press release: National Aboriginal heath plan will help close the gap (nacchocommunique.com)
By nacchomedia • Posted in Aboriginal health in the news	• Tagged Aboriginal, Aboriginal Australians, Aboriginal Community Controlled Health Service, Australia, Australian Indigenous, First Nations, Marcia Langton, National Health and Medical Research Council, Sandra Eades
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text:
Q: Entity Framework not able to add data I'm doing a project where I have to use EF, but trying to add new data to the table seems to fail every time. I have no knowledge to why/how I can fix it.
The code executing is:
private static void AddCustomer()
{
        WriteAdminMenu("Add new customer");
        Console.Write("First name: ");
        ...
        WriteAdminMenu("Adding customer...");

        using (var db = new EshopContext())
        {
            db.Addresses.Add(new Address(customerStreet, customerZip, customerCity, customerCountry));
        }
    }

And I get the following error:

System.InvalidOperationException: No suitable constructor was found for entity type 'Address'. The following constructors had parameters that could not be bound to properties of the entity type: cannot bind 'zip' in 'Address(string street, string zip, string city, string country)'

Context file:
public class EshopContext : DbContext
{
    public DbSet<Customer>? Customer { get; set; }
    public DbSet<Address>? Addresses { get; set; }
    public DbSet<Order>? Orders { get; set; }
    public DbSet<Product>? Products { get; set; }
    public DbSet<Tag>? Tags { get; set; }

    protected override void OnConfiguring(DbContextOptionsBuilder options)
       => options.UseSqlServer("Data Source=TotallyMyIp;Initial Catalog=MyDatabaseName;Persist Security Info=True;User ID=TotalyMyUserName;Password=totallySecretPassword");
}

And my address model:
public class Address
{
    public int Id { get; set; }
    public string Street { get; set; }
    public string Zipcode { get; set; }
    public string City { get; set; }
    public string Country { get; set; }

    public Address(string street, string zip, string city, string country)
    {
        Street = street;
        Zipcode = zip;
        City = city;
        Country = country;
    }
}

A: The framework has no way to know that zip is the same as Zipcode.
Keep your names consistent:
public Address(string street, string zipcode, string city, string country)

redpajama_set_name: RedPajamaStackExchange


NGL7 SIS 150 Industrial Gas Burner. Used condition. with built in controller. Runs on LPG or Natural Gas A good way to heat up a furnace, oven or kiln.
Electric kiln with pyrometer. 1100C max, 2400 watts, 240 volts 10amp single phase. Great working condition. The pyrometer needs a repair before it will work or can be used without. Pick up Hallett Cove, 5158. External measurements: Approx 55cm wide x 54cm deep x 53cm high. Internal measurements: Approx 30cm wide x 31cm deep x 31cm high.
Tetlow kiln, last used 5 years ago, 3 phase. Can load with forklift.


text:
Startpage Privacy Inertia Study: Three-quarters of Americans are very concerned about their online privacy, but most stall at taking any significant action
"When we don't know what to do, we often delay doing anything, despite expecting to be worse off for this delay," says top procrastination researcher
Feb 10, 2021, 09:00 ET
THE HAGUE, Netherlands, Feb. 10, 2021 /PRNewswire/ -- Startpage, the world's first and most private search engine, today announced results of its survey exploring the attitudes of Americans towards protecting their own privacy online. The results found a gap between the high levels of online privacy awareness and concern respondents report, and the low levels of action they take to combat increasingly egregious assaults on their privacy.
Awareness, Concern and Discomfort with Online Privacy Malpractices Run High
Internet usage in 2020 rose sharply compared to pre-pandemic levels. More online activity also drove more consumer consciousness around what happens to their online data; nearly three-quarters (72%) of Americans say they are "very concerned" to "extremely concerned" about their online privacy. Additionally, over the past year almost two-thirds (62%) of U.S. consumers cited stated that they have become more aware of how their personal data is used online, including:
Noticing ad targeting based on their browsing history (57%)
Reading an article about how personal data is used online (47%)
Noticing an online ad targeting their location (46%)
Despite what many brands want to believe, 42% of Americans are not comfortable receiving ads that target their browsing history, location, sexual identity, political affiliation, and/or age. People also see more value in their personal data staying private than them receiving personalized recommendations for TV shows or products, tailored search results, or even exclusive deals.
Despite Privacy Concerns, Consumer-Level Inaction Reins Supreme
Beyond getting a pulse on Americans' online privacy concerns, the survey explored what action individuals have taken, and plan to take, to protect their personal data online. Startpage found a gap between the 72% of respondents that are very or extremely concerned about their online privacy and concrete action taken to combat these concerns.
Almost a fifth of people (17%) admitted to taking no action to protect their personal data online in the past 12 months and among those that did, the majority (60%) updated a password online. Not many people are actively taking precautions beyond changing passwords.
'Privacy Inertia': The Psychological Barrier Preventing Action on Privacy
The survey findings point to a collective 'privacy inertia' plaguing people's ability to fight back against the understood assault on their privacy. For example, among certain groups, breaking through the 'network effect' is perceived to be almost too tough to try. Younger age groups and men are most likely to say it's easier to break up with a romantic partner or lose 10lbs than it is to quit using Google or social media.
To help better understand why high levels of awareness don't translate to high levels of action, Startpage sought the expertise of Timothy A. Pychyl, Ph.D., Associate Professor of Psychology at Carleton University, whose research on procrastination reveals two patterns in the survey data. First, 'lack of familiarity' with privacy-focused options or how to make the change was perceived by half of respondents to be the number one barrier to enacting their intentions for change. According to Dr. Pychyl, this mirrors results in his research where uncertainty highly correlates with procrastination:
"'Privacy inertia' shares many similarities with other irrational delays in our lives. When we don't know what to do, we often delay doing anything, despite expecting to be worse off for this delay, which is, of course, the irrational self-defeating aspect of procrastination," said Dr. Pychyl.
"In addition, procrastination research makes it clear that present-self would rather put off any effort to future-self. Despite the best of intentions and even a sense of urgency to get something done, if the task at hand is aversive in some way because we don't know what to do, or it's perceived as boring, frustrating or effortful, we're more likely to put it off," he continued.
So how can Americans get motivated to make a privacy-related change in 2021? Dr. Pychyl offers a tip based on psychological science: "Making specific implementation intentions for action is effective, particularly in the form of the conditional 'if . . . then.' For example, 'if I'm about to look up a term with a search engine, then I will take five minutes and choose a private search tool.' This approach provides a clear cue for action which makes it more likely that we'll remember our intention and act."
Robert E.G. Beens, CEO of Startpage implores people to follow the approach laid out by Dr. Pychyl, stating: "If millions of consumers each took one quick, motivated action to protect their privacy in 2021, we'd go a long way collectively to regaining our online freedom."
Privacy-Focused Online Options For Consumers
There are a plethora of privacy-focused online search engines, browsers and other tools available (and free) for any user. Startpage is available as a default search engine in various browsers in just a few clicks, which gives users instant access to private search. For a great list of other tools to help you take back control of your privacy, check out ThinkPrivacy.
Startpage commissioned SMS Research to conduct the survey of 1,101 Americans aged 18+ between Jan. 19 - 20, 2021.
About Startpage
Startpage is the world's most private search engine. Founded in the Netherlands in 2006, the company has grown to become the preferred choice of anyone who cares about accurate search results as much as they care about their privacy. Startpage doesn't track, log, share or sell user data or search history. The company offers an exclusive feature - "Anonymous View" - which allows users to browse other websites without being tracked. Startpage offers best-in-class search results and applies its proprietary anonymizing process to protect users' online privacy. The company delivers completely un-profiled search results and protects consumers from annoying ads and price trackers. Startpage protects its world-wide users by adhering to the stringent Dutch and EU privacy laws, including GDPR. To find out more about how to change to the world's most private search engine, read installing the Startpage browser extension or setting Startpage as your default homepage. Follow the company on Twitter @startpage or sign up for its newsletter Privacy Please! at https://www.getrevue.co/profile/Startpage.
SOURCE Startpage
https://www.startpage.com


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Home/News/Unite signs apprenticeship training agreement with pladis in the UK
Unite signs apprenticeship training agreement with pladis in the UK
Unite has signed a 5-year training agreement establishing apprenticeships at the UK operations of pladis, the transnational biscuit, chocolate and confectionery company owned by Turkish conglomerate Yildiz Holding. Under the agreement close to 50 engineering apprentices will be recruited and trained by 2020 in the repair and maintenance of processing and packaging equipment at the company's seven UK sites, with the full involvement of Unite members.
Pladis (with a small 'p') was established in 2016 when Yildiz split off its biscuit, chocolate and confectionery unit to establish a separate transnational company bringing together United Biscuits, Ulker, Godiva and DeMet's Candy.


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Q: Função que imprime índices de um array de forma incremental Estou tentando implementar uma função que pode ser em PHP ou Js que pega os valores de um array e exiba eles, só que pulando os índices de forma incremental.
Por exemplo, tenho o seguinte array
numeros = ["0", "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20"];

Que deverá exibir os seguinte números 0, 2, 5, 9, 14...
Como pode perceber, ele inicia exibindo o índice de valor 0, pula um índice da posição atual e exibe o valor 2, pula dois índices da posição atual e exibe o valor 5, e assim por diante.
Nesse exemplo a saída deverá ser os valores
0, 2, 5, 9, 14, 20

A: <?php

   $numeros = ["0", "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20"];
   $indice = 0;
   $incremento = 0;
   do{
    echo $numeros[$indice+$incremento]."<br/>";
    $indice++;
    $incremento += $indice;
   }while($indice+$incremento < count($numeros));

Explicações:
Você precisará de duas variáveis: uma para percorrer o array ($indice) e outra para incrementar os saltos ($incremento), elas devem está interligadas para que o avanço de uma influencie no avanço da outra até o fim do array, utilizei a estrutura de laço do while, para que a primeira interação fosse realizada.
Entendendo o loop
     $indice|$incremento|Posição do elemento| Número

  1ª:   0   |     0     |         0         |  "0"
  2ª:   1   |     1     |         2         |  "2"
  3ª:   2   |     3     |         5         |  "4"
  4ª:   3   |     7     |         10        |  "9"
  5ª:   4   |     11    |         15        |  "14"
  6ª:   5   |     16    |         21        |  "20"

E o laço é encerrado pois a soma do $indice + $incremento tem que ser menor que a quantidade de elementos do array $indice+$incremento < count($numeros).
Espero ter contribuído;

A: Em JavaScript:
function skipIndex(arr){
  let newArr = []
  for (let i = 0, jump = 2; i < arr.length; i+=jump, jump++){
    newArr.push(arr[i])
  }
  return newArr
}


The second annual Celebrating Seva event in honour of Paviter Singh Bassi, a 21-year-old young Bramptonite who died after he was beaten in front of a high school takes place this Friday, April 12 at The Rose Theatre.
Performances by Noyz, Minority Mindset, The Lost Strings, a hukamnama recitation and a silent auction featuring 30 artists and local businesses will start at 6 p.m. and run until 10 p.m.
Paviter Singh Bassi, 21, was killed March 19, 2018. Five suspects have been charged in the attack in front of Sandalwood Heights Secondary School on Sandalwood Parkway near Torbram Road.
His family said they established The Paviter Fund in his memory and 100 per cent of the proceeds of the event will be donated to that fund, which carries on Paviter's dedication to serving and giving back to his community.


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ROBERT PIRES RETURNS TO INDIA WITH ARSENAL
Robert Pires is returning to India with the club next week to take part in the official Premier League Live (PL Live) event in Bengaluru.
Pires was in Mumbai last year for the club's first official screening in India and always receives a fantastic reception, not just from Arsenal fans but football fans in general after his time playing for FC Goa in the Indian Super League for the 2014/15 season.


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ChromaVision Targets National AP Market
Automated cellular imaging technology will support company's expansion
By Robert Michel
| From the Volume XI No. 12 - August 30, 2004 Issue
Florida Labs Face Off With Hurricane Charley
Oncology's Potential Drives AP Lab Expansion
CEO SUMMARY: Three new business strategies are moving ChromaVision into different segments of the laboratory testing marketplace. The company has built a new laboratory facility and will support local pathology groups with advanced diagnostic technology. It is also expanding its presence in the research and development area of pharmacodiagnostics, with an emphasis on oncology.
PROFIT AND OPPORTUNITY are the motivations behind a new business strategy and a new executive team at ChromaVision Medical Systems, Inc., based in San Juan Capistrano, California.
Profit, or rather the lack of it, caused ChromaVision to rethink its existing business model. It was 2000 when it received FDA clearance to sell its Automated Cellular Imaging System (ACIS®). During the past four years, the number of ACIS instruments placed in clinical use has increased steadily. But profits at ChromaVision have proved elusive.
Two New Executives
Faced with the need to boost profitability, the company is transforming itself. It adopted a three-pronged business strategy. To implement this strategy, it recruited a new senior executive team. On July 22, it announced that Ronald A. Andrew, Jr. was to be the new President and CEO. Then, on August 18, ChromaVision announced that Kenneth J. Bloom, M.D. had joined the firm as Medical Director, effective that day.
Andrews was most recently the Senior Vice President, Global Marketing and Commercial Business Development, for Roche Molecular Diagnostics. Bloom was Senior Medical Director at US LABS, Inc., based in Irvine, California.
ChromaVision's two new executives will tackle the company's new, three-pronged business strategy. First, it will expand sales of its Automated Cellular Imaging System into markets outside the United States. Second, it has built a new laboratory facility and will compete directly for specimens with other anatomic pathology (AP) specialty laboratories. Third, ChromaVision is beefing up its involvement with pharmacodiagnostics, including participation in clinical trials to develop proprietary companion diagnostics.
ChromaVision has ample cash to execute these new business strategies. In February 2004, the company received $5 million in new funding from Safeguard Scientifics, Inc. ChromaVision is a majority-owned subsidiary of Safeguard. One month later, in March, ChromaVision closed a $21 million securities offering. It also announced a research collaboration with UCLA.
ChromaVision's transformation from a manufacturer and distributor of AP imaging systems based on proprietary technology into a provider of direct testing is an unexpected turn for the company. It now becomes a direct competitor in the lab services marketplace.
ChromaVision's new business strategy is directly rooted in the firm's experience since it introduced ACIS earlier in this decade. It has an automated micro- scope with computer-based color imaging technology. ACIS can detect, count, and classify cells of clinical interest based on recognition of cellular objects of particular color, size and shape.
Diagnostics Marketplace
In 2000, ChromaVision obtained a broad clearance from the FDA and focused on market penetration and commercialization of ACIS. This broad FDA 510K allows customers to use ACIS in a variety of ways. In addition ACIS has three specific FDA clearances: MRD Micrometastases (2000), Estrogen Receptor and Progesterone Receptor (2002), and HER2 (2003).
ChromaVision estimates that about 30% of all new cases in these areas run on its ACIS at hospitals and research labs across the country. It says it has about 261 customers in the clinical market and 35 customers in the research market.
To pursue its new business strategies, ChromaVision ended its longstanding relationship with US Labs, Inc. in June 2004. The partnership processed specimens and provided imaging to customers via CD/ DVD/Web. The referring pathologists determined the cells to be evaluated, performed the diagnosis, and billed for the professional component.
ChromaVision intends to perform these services itself. It built a new laboratory in San Juan Capistrano. As a reference laboratory service provider, ChromaVision starts from a strong position. It has an installed base of 166 ACIS placements and 95 ACCESS workstations. It is also modeling its operations on the successful things done by other national AP labs. A number of its recently-hired laboratory staff have come from these companies, including IMPATH.
As its three new business strategies gain traction in the marketplace, ChromaVision Medical Systems has the potential to become a new type of laboratory/diagnostic business model. It is using ACIS, a proprietary imaging technology, to develop a unique relationship with its anatomic pathologist-clients.
ChromaVision can sell its full ACIS system to pathology laboratories seeking to do 100% of the work themselves. Alternatively, ChromaVision can have a role as an esoteric reference laboratory, providing technical services, then transmitting the resulting AP images to the referring pathologist. Alternatively, it can perform both the technical and the professional services at a client's request.
ChromaVision Medical Systems demonstrates that the national marketplace for anatomic pathology services continues to evolve. New business forms and new professional relationships between diagnostic technology developers and laboratories are steadily reshaping all aspects of the laboratory testing marketplace.
It is another example—and another early warning—to local anatomic pathology group practices that their profession is evolving.
Tags: aco, anatomic pathologist, Anatomic pathology, anatomic pathology services, cap, cellular imaging, clinical trials, companion diagnostic, Companion diagnostics, Diagnostic technology, diagnostics market, ehi, FDA Clearance, lab service, lab services, laboratories, laboratory service, laboratory staff, laboratory test, laboratory testing, molecular diagnostic, pathologists, Pathology group, pathology groups, pathology lab, pathology laboratories, pathology service, pathology services, roche molecular diagnostic, roche molecular diagnostics, specialty lab, specialty laboratories, the laboratory
Volume XI No. 12 – August 30, 2004
COMMENTARY & OPINION BY R. LEWIS DARK
Raising the Bar on Laboratory Management Skills
Mayo's Scottsdale Hospital Lab Hits Big "Lean" Home Runs
Leonard Joins AEL's Board, Cenetron Is Newest Acquisition
Cerner, Gajema Software, India Labs Look to U.K. & U.S.A
"August 30, 2004 Intelligence: Late Breaking Lab News"
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The Fourth Crusade and the Fall of Constantinople
Posted on October 20, 2018 by MAMcIntosh
Attack of the Crusaders on Constantinople, miniature in a manuscript of 9 La Conquête de Constantinople by Geoffreoy de Villehardouin, Venetian ms. / Wikimedia Commons
Instead of Jerusalem as initially intended, the target ended up being Constantinople, capital of the Byzantine Empire.
By Mark Cartwright / 09.03.2018
A painting by Eugene Delacroix (1798-1863 CE) depicting the entry of the Crusaders into Constantinople in 1204 CE during the Fourth Crusade. (Louvre, Paris) / Wikimedia Commons
The Fourth Crusade (1202-1204 CE) was called by Pope Innocent III (r. 1198-1216 CE) to retake Jerusalem from its current Muslim overlords. However, in a bizarre combination of cock-ups, financial constraints, and Venetian trading ambitions, the target ended up being Constantinople, capital of the Byzantine Empire and the greatest Christian city in the world. Sacked on 12 April 1204 CE, Constantinople was stripped of its riches, relics, and artworks, and the Byzantine Empire was divided up between Venice and its allies. The Fourth Crusade thus gained its infamous reputation as the most cynical and profit-seeking of all the crusades.
East-West Suspicion
The Byzantines saw themselves as the defenders of Christendom, the beacon which shone out across the Mediterranean and central Asia, hosts to the holiest city outside Jerusalem, and the rock which stood against the tide of Islam sweeping in from the east. By the western half of the old Roman Empire, though, the Byzantines were regarded as decadent, shifty, and untrustworthy; even their religious practices were suspect. This essential division between the east and west had caused constant problems in all the previous crusades, and it was to crop up again in this one.
There were also more concrete sources of division, the historical rivalry between popes and emperors, and the rising ambition of western states to wrest from Byzantium the remnants of its empire in Italy were fuelled by the failures of the crusades in permanently securing the Holy Land for Christendom. Blame was apportioned to either side for the lack of success. The Byzantines were considered to lack the will to fight the common Muslim enemy while, from the other side, the Crusaders were seen as opportunists out to grab the choicest parts of the Byzantine Empire in the east. In a sense, both sides were right in their judgement.
Venice and the Fourth Crusade
A portrait by Domenico Tintoretto of Enrico Dandolo, Doge of the Republic of Venice (r. 1192-1205 CE) and prime instigator of the sack of Constantinople in 1204 CE during the Fourth Crusade. / Wikimedia Commons
The Third Crusade (1187-1192 CE), although achieving some notable military successes, had failed completely in its original objective of recapturing Jerusalem from the Muslim Sultan of Egypt and Syria, Saladin (r. 1174-1193 CE). The celebrated Sultan was now dead, but the Holy City remained in Muslim hands. Yet another crusade was required. The Fourth Crusade was thus called for by Pope Innocent III (r. 1198-1216 CE) in August 1198 CE. As previously, those who went to the Holy Land and fought the infidels would receive a remission of their sins, but as an added incentive, Innocent III now extended this 'benefit' to those who gave the necessary money to fund a warrior to go in their stead.
The Pope's timing was not the best, especially considering the Holy City had anyway been in Muslim hands since 1187 CE. In the final years of the 12th century CE, all four monarchs of Europe's most powerful kingdoms, England, France, Germany, and Spain, were busy with internal affairs, and in the case of England and France, serious territorial squabbles with each other. Worse still, in April 1199 CE, the great Crusader king Richard I of England (r. 1189-1199 CE), who had promised to return to the Holy Land and finish his undone work during the Third Crusade, died on campaign in France.
Unlike the previous Crusade, then, this was not to be a "Kings' Crusade". Still, a good number of second-tier nobles were inspired to join up or 'take the cross', as it was known, especially from northern France. There were the counts of Champagne and Blois (although the former would die before the expedition got underway), Geoffrey of Villehardouin (who would later write his Conquest of Constantinople, an important record of the Crusade), Count Baldwin of Flanders, and Simon de Montfort. In August 1201 CE the leader of the expedition, after the untimely death of Theobald of Champagne, was selected. The choice was an immensely rich and chivalrous Italian with an impressive Crusader pedigree in his family, Marquis Boniface of Montferrat. Perhaps significantly, given future events, Boniface also had family connections with the Byzantine Empire, one of his brothers marrying the daughter of Byzantine emperor Manuel I (r. 1143-1180 CE) and another brother marrying the sister of the deposed Byzantine emperor Isaac II Angelos (r. 1185-1195 CE).
Objective Constantinople
Historians continue to debate the exact reason why the Crusaders then turned on Constantinople instead of Jerusalem, but one crucial ingredient in the troublesome mix of mutual suspicions between the western powers and Byzantium was the Republic of Venice and one man, in particular, the Doge Enrico Dandolo (r. 1192-1205 CE). Intent on winning Venetian domination of the trade in the east, Dandolo well remembered his undignified expulsion from Constantinople when he had served there as an ambassador. This seemed as good an opportunity as ever to install a new sympathetic emperor. Alexios IV Angelos (r. 1203-1204 CE), whose father Isaac II Angelos had been deposed as emperor seven years earlier, had been touting for western support for some time. This would permit Venice to get several steps ahead of long-time trade rivals Pisa and Genoa in cornering the trade market within the Byzantine Empire. It may, then, have been the goal of Dandolo and the Crusaders to merely pass through Constantinople, put a new emperor on the throne and then carry on to Jerusalem with their ships resupplied and their coffers refilled. Given the recent history of rebellions and takeovers in Byzantium, this was perhaps a rather simplified view of possible events. Certainly, things turned out to be a whole lot more difficult for everyone involved.
In addition to material gains for Venice, another possible motivation for targeting Constantinople is that the Pope might achieve the supremacy of the western Church once and for all over the eastern Church. Meanwhile, the Crusader knights would not only gain revenge on the duplicitous Byzantines for their unhelpful support of previous Crusades but also surely pick up some glory and handsome booty in the process. It may not, as some conspiracy-theory historians have claimed, have all been so cynically planned beforehand by all parties, but in the end, it is exactly what happened with the exception that the Fourth Crusade ended with the fall of the Byzantine capital and Jerusalem was left for a later date.
The Sack of Constantinople
A 16th century CE painting by Domenico Tintoretto depicting the Venetians attacking the sea walls of Constantinople in 1204 CE during the Fourth Crusade. / Wikimedia Commons
The Crusader army arrived outside Constantinople on 24 June 1203 CE. The force consisted of around 4,500 knights and their squires, up to 14,000 infantry, and 20,000-30,000 Venetians. The first target was the Byzantine garrison at nearby Galata on the other shore of the Golden Horn. Thus, the massive chain which blocked the harbour of the Golden Horn could be lowered and the Crusader fleet could directly attack Constantinople's sea walls if required. At the same time, siege engines were built in readiness to attack the city's formidable fortifications on the land side, the Theodosian Walls. The incumbent emperor Alexios III Angelos (r. 1195-1203 CE), caught completely unprepared by the arrival of the Crusaders, fled the city on 17 July 1203 CE.
The Crusaders first move was an attempt to put their own supporter on the throne, Alexios IV Angelos along with his father, the former emperor Isaac II Angelos. It was now, though, that the westerners realised that Alexios' promises had all been false. The pair were deeply unpopular with the Byzantines, largely thanks to sustained propaganda against them by their successor, the departed Alexios III, and the obvious threatening presence of the Crusader army camped outside the capital. Consequently, with the throne now effectively empty and with the support of both the people and the army, a usurper stepped in, one Alexios V Doukas, nicknamed 'Murtzurphlus' for his bushy eyebrows. Doukas promised to defend the city at all costs against the Crusaders and he seized the throne after executing his predecessors, father and son together, in January 1204 CE. Constantinople's walls were strengthened, towers were heightened, and several raids made against the Crusader camps.
A map indicating the division of the Byzantine Empire following the sack of Constantinople in 1204 CE during the Fourth Crusade. / Image by LatinEmpire, Wikimedia Commons
The Crusaders, with diplomatic avenues exhausted, their supplies dangerously low, and their ships in need of vital repairs and maintenance, had now little option but to try and take the city. They launched an all-out attack on the morning of 9 April 1204 CE, but the Byzantines repelled it. Then, on 12 April, the Crusaders attacked the weaker sea walls of the harbour and targeted two towers in particular by lashing their ships together and ramming them repeatedly. Initially, the defenders held on, but eventually, the attackers forced their way through on both the sea side and the land side, the attackers smashing through the city's gates. A slaughter of the defenders and the city's some 400,000 inhabitants followed. Citizens were raped and massacred, buildings were torched, and churches desecrated. Doukas fled to Thrace, and three days of looting followed where artworks were destroyed, precious goods were melted down, and religious relics were taken back to Europe.
After the looting finally ended, the Partitio Romaniae treaty, already decided on beforehand, carved up the Byzantine Empire amongst Venice and its allies. The Venetians took three-eighths of Constantinople, the Ionian islands, Crete, Euboea, Andros, Naxos, and a few strategic points along the coast of the Sea of Marmara. Thus, Venetian control of Mediterranean trade was now almost total. On 9 May 1204 CE, Count Baldwin of Flanders was made the first Latin Emperor of Constantinople (r. 1204-1205 CE) and crowned in the Hagia Sophia, receiving five-eighths of Constantinople and one-quarter of the Empire which included Thrace, northwest Asia Minor, and several Aegean islands. Boniface of Montferrat took over Thessalonica and formed a new kingdom there, which also included Athens and Macedonia. In 1205 CE, following Baldwin's capture after a battle with the Bulgars defending his territory in Thrace and subsequent death in a Bulgarian prison, William I Champlitte and Geoffrey I Villehardouin (nephew of the historian of the same name) founded a Latin principality in the Peloponnese while the French duke Othon de la Roche grabbed Attica and Boeotia.
The Byzantine Empire would be re-established in 1261 CE, albeit a shadow of its former self, when forces from the Empire of Nicaea, the centre of the Byzantines-in-exile (1208-1261 CE), retook Constantinople. Emperor Michael VIII (r. 1259-1282 CE) was then able to place his throne back in the palace of his Byzantine predecessors.
The Fourth Crusade in the Holy Land
Perhaps understandably, the shocking fall of Constantinople has grabbed almost all the attention of the Fourth Crusade, but there was a small contingent of western Crusaders, led by Renard II of Dampierre, which did fulfil the original purpose of the expedition and reach the Middle East, better late than never, in April 1203 CE. The 300 knights were too few to ever consider attacking well-fortified Jerusalem, or any other important city for that matter, but they did manage to assist the Latin states in perpetuating their precarious existence in the Muslim-dominated Middle East.
In September 1203 CE, in coalition with the now tiny Kingdom of Jerusalem, the Crusaders attacked a few minor targets in Muslim-held Galilee. A plague at Acre then wiped out half of the Crusader force, but as the ruler of Damascus, Al Malik al-'Adil, seemed intent on avoiding a direct confrontation, certain territories were conceded to the Kingdom of Jerusalem including Nazareth, Jaffa, Ramla, and a strip of land near Sidon. Then, in August 1204 CE, the Crusaders twice successfully attacked forces from Hama in central Syria. It was, though, all rather insignificant given the original lofty ambitions of Pope Innocent III. With the Fifth Crusade (1217-1221 CE) concentrating on North Africa and Egypt, it would not be until the Sixth Crusade (1228-1229 CE) that Christian ambitions in the Middle East were revived.
Originally published by the Ancient History Encyclopedia under a Creative Commons: Attribution-NonCommercial-ShareAlike 3.0 Unported license.
This entry was posted in Crusades, History, Medieval, Middle Ages. Bookmark the permalink.
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Fake Ariana Grande Post Circulates Amid Taylor Swift and Scooter Braun Feud
Singer weighs in on the controversy surrounding her manager and the "ME!" singer
By Mike Vulpo Jul 01, 2019 10:45 PMTags
MusicTaylor SwiftAriana GrandeCelebrities
Watch: Taylor Swift "Grossed Out" That Scooter Braun Will Now Own Her Music
UPDATE: E! News has learned the social media post circulating online is a fake. In other words, Ariana Grande has not spoken out about the highly publicized situation between Taylor Swift and Scooter Braun.
Ariana Grande appears to have found herself in the middle of Taylor Swift and Scooter Bruan's disagreement.
On Monday morning, the singer reportedly posted an Instagram Story where she apologized to the "ME!" singer.
"I would never support someone with the intentions of hurting another person…I spoke to him myself as soon as I heard…I don't mean to make this public or get involved but I've noticed mixed opinions where people used my name," she wrote in a now deleted post. "Please spread love. I'm so so sorry Tay. Ly. Stay strong."
Ariana added, "Deleted in a min. This didn't happen. love. Always. Tour dates being posted shortly."
Back on Sunday, Taylor went on Tumblr and revealed Scooter will own her music catalogue. The Grammy winner said she is "sad and grossed out" and heartbroken about the news.
She also went on to claim the celebrity music manager had been bullying her for years. "Some fun facts about today's news: I learned about Scooter Braun's purchase of my masters as it was announced to the world," Taylor shared. "All I could think about was the incessant, manipulative bullying I've received at his hands for years."
While the "Shake It Off" singer received support from fans and friends like Halsey, Todrick Hall and Iggy Azalea, others like Justin Bieber and Demi Lovato were quick to defend Scooter.
"I have dealt with bad people in this industry and Scooter is not one of them. He's a good man," Demi wrote on Instagram Stories. "Personally, I'm grateful he came into my life when he did. Please stop 'dragging' people or bullying them. There's enough hate in this world as it is."
While fans are wondering if Taylor will address the latest developments, she's letting her initial Tumblr post speak for itself. She's also looking forward to a future where she has more control over her work.
"Thankfully, I am now signed to a label that believes I should own anything I create," Taylor wrote on Tumblr. "Thankfully, I left my past in Scott's hands and not my future. And hopefully, young artists or kids with musical dreams will read this and learn about how to better protect themselves in a negotiation. You deserve to own the art you make. I will always be proud of my past work. But for a healthier option, Lover will be out August 23. Sad and grossed out, Taylor."
(Originally published July 1, 2019 at 1:07 p.m. PST)


For The Red Tree, a collaboration between the Australian Chamber Orchestra and Gondwana Voices created by Michael Yezerski and Richard Tognetti, this is potentially the very quality that could allow the project to go beyond word painting to become a whole work, one that is truly interdisciplinary. earthquake resistant design of structures pdf Tree height varies with the characteristics of each species but is usually in the range of 1m - 2m. Super: These trees are from the same batch as above, but are the larger, stronger trees of that line.
–"Well" said the tree, straightening herself up as much as she could, "well, an old stump is good for sitting and resting. Come, Boy, sit down…and rest." convert pdf to publisher online 25/01/2017 · The Red Tree is a story that encourages us to ask rather than answer questions. Questions that do not necessarily have answers because it is not about reaching conclusions but rather exploring ideas, feelings and themes.
25/01/2017 · The Red Tree is a story that encourages us to ask rather than answer questions. Questions that do not necessarily have answers because it is not about reaching conclusions but rather exploring ideas, feelings and themes.
This is such a beautiful book both for its message and the stunning illustrations. The Red Tree is an extremely sensitive and empathetic book that leaves a mark long after reading it.


The Theological Fellowship at Covenant Seminary fosters and promotes Christ-centered scholarship both for students considering future studies, and for trained ministry leaders seeking depth in areas not covered in their curriculum. Most importantly, through collaboration with professors and camaraderie with students, the group is a safe place for dialogue, encouragement, and prayer. We carry this out in our weekly meetings, an annual theological conference, our many ministry lunches, and several guest lectures each year. Keep updated by liking the group's Facebook page.
Varies; check with group leaders.
Anyone interested in theological inquiry, wanting to apply theological skills in the pastorate or counseling, or considering post-seminary studies. All are welcome.


Steffi Arvanitakis is beautifully offering to share her loving heart, hands and wisdom with us around caring, holding and moving birthing families through their passage to mothering and the sacred space that follows.
This will be an afternoon to honour the sacred nature of birth through simple practices of nurturance, meditation & mindfulness, gentle bodywork & an introduction into the use of the Rebosso & the 'Closing of the Bones' ritual, Womb Wrapping & Womb Steaming.
Come & fill your cup as a Birthworker & a woman & enjoy a cosy Winter afternoon assured to nourish & enrich you.


Another award representing the second word in the PLM motto, Kaunlaran, is being conferred on SANDRA MEI BRANZUELA of the College of Science (Chemistry) by the University's Executive Vice President and six Vice Presidents, otherwise known as the PLM Top Executive Award.
The Gawad ng Kaunlaran and a cash gift of P20,000 are awarded to Ms. Branzuela best employed for her creativity, passion and skill to launch innovation that will spur progress. In her case – for inventing a Flame Emission Photometric Determination of Iron via Digital Imaging Based Detection (DIB-FEP) "from scratch" at the Creative Category of the DOST Regional Invention Contest and Exhibits.
The award recognizes her effort to build the instrument for the detection of metals in liquids, a photometer box normally used in laboratories, that only cost her around P5-10,000 to build compared to 1.5 million pesos when purchased commercially. All in all, it took her at least two extensions on the original year and a half period within which her mentor – Professor John Rafael Granada – expected her to complete the contraption.
It was the result of blood, sweat and tears and many nights of sleep deprivation and the use of only a smartphone and a digital camera as data-gathering tools. But because of her perseverance and hard work, her Eureka! Moment was twice as sweet and earned her DOST's Sibol award for young inventors and the respect of the PLM community. Please give her a big round of applause to show her how much we appreciate her initiative and how much we take pride in her achievement.


Between all the contemporary shows at Amsterdam Fashion Week it's always nice to see a show with pieces that you just want to grab, right from the catwalk. For me, that show is always Studio JUX.
Studio JUX is a young, Dutch brand with its own workshop in Nepal. Since Nepal is a very poor country, with a lot of people but very few jobs, JUX makes sure that their tailors receive a fair salary. Not only are they do-gooders for other people, but since they exclusively use sustainable materials for their clothes, it's also good for you. Honest clothing that you can easily wear and have fun in. (JUX is a German word for having fun).
Their line for fall/winter 2013/14 was based on the idea that in hard times, people tend to keep to themselves a lot. They always cover up, as if they need armour. However, founders Carlien Helmink and Jitske Lundgren think that if you open up, good energy will come your way. This resulted in a line that's fun, colourful and easy to incorporate in your wardrobe.
Colours like dark indigo, burgundy and mustard yellow, combined with pink, blue and beige soft pastels, gave the clothes that 'good energy' feel, while the shapes were a bit more business-like. Suits for men and women, and even one with shorts. (You can see this one below, together with an adorable little pinkish blouse and cute socks in high heels. I wanted to wear it immediately and keep it on all day, every day). Shiny fabrics alternated with tweed and knitted goods. The models' make-up was natural, but a little heavier on the eyes. Fall make-up, if you will. The music reminded me of spring, and the alternating colours on the screen behind the models only amplified that feeling.
The brand succeeded in translating their story and ideas into the real deal. Even though I'm a big fan of summer, I can't wait for fall to arrive so I can début the pieces that will end up in my closet on the streets of Amsterdam. With an open, happy attitude of course.


text:
Simple solution for [Kaggle competition](http://www.kaggle.com/c/word2vec-nlp-tutorial) using Naive Bayes calssifier.

## Usage

Split train data in ratio 70/30 and check how algorithm train and test your sample result.

```bash
$ python imdb_reviews --test
```

Predict result for Kaggle competition tests anda save them in `data/predictedData.csv` file

```bash
$ python imdb_reviews --predict
```

redpajama_set_name: RedPajamaGithub


text:
Q: How to create language for microsoft speech recognizer I am developing a Speech Recognition Application in C# by using Microsoft Speech API.
I need a speech recognizer for the following language :

*

*uz-Latn-UZ

The Speech Recognition Language does not exists for this language. So I wanna create my own Lightweight Speech Recognition Language for this language.
How can i do this?


Practical underbed storage drawer perfect for keeping things organised. Easy pull out. Also available in extra large to fit under a double bed. Options available to convert to a additional bed with slatted base and mattress.


Royal College of Surgeons in Ireland, Education and Research Unit, Beaumont Hospital, Dublin 9.
My research focus is neural engineering and rehabilitation with an emphasis on experimental and statistical models that examine predictors of disease states or events in order to improve function. My principal research interest is the exploration of locomotion as a window to understand and improve cognitive function in older adults and individuals with Parkinson's disease and Chronic Obstructive Pulmonary Disease (COPD). During my PhD, I investigated kinematic predictors of conversion to mild cognitive impairment in older adults employing the TILDA dataset. Subsequent to this, as a postdoctoral researcher with the FP7 European funded VERVE consortium (tcd, DFKI) I examined the efficacy of a dual motor-cognitive intervention in individuals with Parkinson's Disease who experience freezing of gait. I also find the complexity of disease (effect of personal characteristics, comorbidities) fascinating and have gained tremendous expertise on this which I am currently exploring in other populations (regression and survival models in uncontrolled asthma cohorts) as part of a clinical trial employing connected health to assess inhaler adherence (INCA, Industry Collaborators). I have been involved with the INCA project since 2007 and I am a patent co-inventor (EU 13766910.7 – 1662 PCT/EP2013067932, US 14/424,964). Previous to this I worked as a validation engineer in the medical device and pharmaceutical industry.
My future research plans are to build on the foundations of my postdoctoral and PhD research to further develop new engineering methods, statistical models, experimental tools and develop interventions in conjunction with clinical and industry partners, in particular gaining funding with those across the European Union and with budding collaborations that I have formed in Britain, Australia and the United States. In particular, I have gained expertise and interest in the collection and interpretation of gait data through biomedical sensors (pressure-sensing mats, 3-D motion analysis, balance boards) and neurological data through experimentation and neuropsychological assessment test, with some experience of other methods (EEG, fNIRS). In addition, I hope to gain funding to develop a brain-training intervention for older adults with COPD. I am involved with several student projects (see webpage and publications below also): Risk factors for hospital re-admission in COPD, Links between gait and cognitive function in the TILDA dataset (cross sectional and longitudinal), ExerGaming as a tool for improving cognitive reserve in Parkinson's Disease.
I am a member of the gait and cognitive research groups in The Irish Longitudinal Study on Aging (TILDA) and have worked in collaboration with the Dublin Neurological Institute, Mater Hospital, Dublin. I am a member of the Trinity Biomedical Sciences Postdoctoral Committee and involved with organising a series of public engagement seminar sessions with The Science Gallery. I have been involved with research into and commercialisation of connected health solutions for healthcare in one form or another since my time at University College Dublin from 2007. I have been involved with writing, administration or project management of several funding proposals: H2020 (http://independence-asd.eu), FP7 (http://www.welcome-project.eu/home.aspx), (http://verveconsortium.eu/) and Enterprise Ireland (eBIOTECH).
I hold a PhD in neural engineering ("Development of Neural Engineering Methods for the Objective Assessment of Cognitive Processing based on Gait Data: An Analysis of a Truly Nationally Representative Cohort of Older Adults" ), an MSc in Bioengineering, a Postgraduate Diploma in Statistics and a BA, BAI in Mechanical and Manufacturing Engineering. During my PhD I completed the M.Sc in Neuroscience Neural Engineering and Neural Imaging courses and the M.Sc in Bioengineering Neural Engineering course.
Statistical Models that examine Predictors of Exacerbation and Clinical Improvement in Asthma Patients.
Self-Motion and Cognitive Function in Aging Populations (links between measures of gait and cognition, specifically executive function, division of attention, dual task changes).
Maguire F, Killane I, Creagh A, Donoghue OA, Kenny RA, Reilly RB. Baseline Association of Motoric Cognitive Risk Syndrome with Sustained Attention, Memory and Global Cognition. Journal of the American Medical Directors Association. Sep 2017. DOI: 10.1016/j.jamda.2017.07.016.
*Butler, J.S., *Fearon, C., Killane, I., Waechter, S.M., Reilly, R.B., Lynch, T. Motor Preparation Rather Than Decision-Making Differentiates Parkinson's Disease Patients With And Without Freezing of Gait, Clinical Neurophysiology (2016), doi: http://dx.doi.org/10.1016/j.clinph.2016.12.019. *J. S. Butler and C. Fearon contributed equally to the paper.
Sulaiman I, Seheult J, MacHale E, Boland F., O'Dwyer SM, Rapcan V, D'Arcy S, Cushen B, Matshediso M, Killane I, Ryder SA, Reilly RB, Costello RC. A Method to Calculate Adherence to Inhaled Therapy That Reflects the Changes in Clinical Features of Asthma. Ann Am Thorac Soc, 2016.
Killane I, Sulaiman I, Mac Hale E, Breathnach A, Taylor T, Holmes M, Reilly RB, Costello RW. Predicting asthma exacerbations employing remotely monitored adherence. Healthc Technol Lett. 2016 Mar 23;3(1):51-5. doi: 10.1049/htl.2015.0058.
Sulaiman I, Mac Hale E, Holmes M, Hughes C, D'Arcy S, Taylor T, Rapcan V, Doyle F, Breathnach A, Seheult J, Murphy D, Hunt E, Lane S J, Sahadevan A, Crispino G, Diette G, Killane I , Reilly RB, Costello RW. A protocol for a randomised clinical trial of the effect of providing feedback on inhaler technique and adherence from an electronic device in patients with poorly controlled severe asthma . BMJ Open. 2016;6.
Sulaiman I, Seheult J, Killane I , MacHale E, Reilly RB, Costello RW. A new clinically relevant method of calculating adherence. Eur Respir J. 2015;46.
*Killane I ,*Feron C, Newman L, McDonnell C, Waechter S, Sons K, Lynch T, Reilly RB. Dual Motor-Cognitive Virtual Reality Training Impacts Dual-Task Performance in Freezing of Gait. IEEE Journal of Biomedical and Health Informatics. 2015;JBHI-00251-2015. *I.Killane and C.Fearon contributed equally to the paper.
D'Arcy S ,MacHale E, Seheult J, Holmes MS, Hughes C, Sulaiman I, Hyland D, O'Reilly C, Glynn S, Al-Zaabi T, McCourt J, Taylor T, Keane F, Killane I, Reilly RB, Costello RC, A Method to Assess Adherence in Inhaler Use through Analysis of Acoustic Recordings of Inhaler Events. PLoS ONE, 2014. 9(6): p. e98701.
T. Munteanu, E.J. Baird, C. Fearon, S.M. Waechter, C. McDonnell, J. Gallego, B. Quinlivan, I. Killane, J.S. Butler, T. Lynch, R.B. Reilly. Freezing of gait (FOG) in PD: Is electroencephalography (EEG) a gateway to elucidating the pathophysiology? 20th International Congress on Parkinson's Disease and Movement Disorders (MDS) Berlin, Germany, 19-23 June 2016.
Sulaiman I, Mac Hale E, Seheult J, D'Arcy S, Rapcan V, Cushen B, Matshediso M, Killane I, Franciosi A, Sahadevan A, Keane M, Keane J, Lane S, Murphy D, Reilly RB, Costello RC. Feedback on Adherence and Inhaler Technique Using the INCA Device: A Randomised Control Trial in Severe Asthma. American Thoracic Society (TS) Conference 2016: A50. Asthma: Observational Studies.
Killane I, Fearon C, McDonnell C, Sons K, Reilly RB. Assessing Variances After A Freezing of Gait Intervention: A Dual Motor-Cognitive Task in a Virtual Environment Joint World Congress of ISPGR (International Society of Posture and Gait Research) and Gait & Mental Function (GMF) Seville, Spain, 2015.
Sheehan KJ, Killane I, Gormley J, Kenny RA, Foran T. The influence of the content of speech production and perception on gait variability. ISPGR GMF, Vancouver, Canada, 2014.
Killane I, Cosgrave N, McDevitt N, , Foran T, Sheehan KJ, Gormley J, Kenny RA, Reilly RB. Comparison of Standard and Poincare Measures of Stride Time Variability. ISPGR GMF, Vancouver, Canada, 2014.
Killane I,Donoghue O, Savva G, Cronin H, Kenny RA, Reilly RB. Variance Between Walking Speed and Neuropsychological Test Scores During Three Gait Tasks Across The Irish Longitudinal Study On Aging (TILDA). Proceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE EMBC'13), Osaka, Japan. Conf Proc IEEE Eng Med Biol Soc. 2013;2013:6921-4. doi: 10.1109/EMBC.2013.6611149.
Killane I, Gallego J, Browett G, Reilly RB. Measurement of Attention During Movement: Acquisition of Ambulatory EEG and Cognitive Performance from healthy Young Adults. IEEE EMBC'13, Osaka, Japan. Conf Proc IEEE Eng Med Biol Soc. 2013;2013:6397-400. doi: 10.1109/EMBC.2013.6611018.
Killane I, Donoghue O, Savva G, Cronin H, Kenny RA, Reilly RB. Association Between Gait Variability and Sustained Attention in a Community Dwelling Nationally Representative Population Sample. ISPGR GMF, Akita, Japan 2013.
Killane I , Donoghue O, Savva G, Cronin H, Kenny RA, Reilly RB. Exploring Correlations between Walking Speed and Cognitive Function using Montreal Cognitive Assessment (MOCA) subscores from The Irish Longitudinal Study on Ageing (TILDA). British Geriatrics Society (BGS) Autumn Scientific Meeting, Harrogate, Yorkshire, England 2012.
Killane I, Brennan C, Savva G, Donoghue O, Cronin H, Kenny RA, Reilly RB. Comparisons between Simple and Complex Gait Tasks across different Executive Function Groups and Tertiles – Cross Sectional Data from The Irish Longitudinal Study on Aging (TILDA). ISPGR GMF, Trondheim, Norway 2012.
Whelan R, Longergan R, Killane I , Reilly RB, Hutchinson M, Tubridy N. Cognitive impairment in multiple sclerosis correlates highly with a delayed P3 component in even related potential testing. World Congress on Treatment and Research in Multiple Sclerosis: Joint meeting of ACTRIMS, ECTRIMS and LACTRIMS (the Americas, European and Latin America Committee on Treatment and Research in Multiple Sclerosis), Montreal 2008.
Creagh, A., Killane, I., Maguire, F., Donoghue, O, Kenny, RA, Reilly, RB, "Examining the links between domains of gait and cognitive decline: a factor analysis approach", Irish Gerontology Society. Age Ageing (2016) 45 (suppl_2): ii13-ii56. doi: 10.1093/ageing/afw159.
Maguire, F., Killane, I., Reilly, RB, "Gait, Cognition and Associated Risk Factors: Insights from Share and TILDA", Proceedings of BioEngineering in Ireland, 2016.
Bennett, G., Killane, I., Cushen, B., Reilly, RB, "Risk Factors for Hospital Re-Admissions in Chronic Obstructive Pulmonary Disease", Proceedings of BioEngineering in Ireland, 2016.
Killane I, Donoghue O, Cronin H, Kenny RA, Reilly RB. Can meaning be found behind mean temporal gait parameters in an older Irish population sample? Correlations between stride time variability and attention.Proceedings of the Nineteenth Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland (Bini19), Meath, Ireland 2013.
Killane I, Browett G, Reilly RB. Measuring Neural Responses During Sitting, Cycling and Walking. Bini17, Galway, Ireland 2011.
Whelan R, Longergan R, Killane I, Reilly RB, Hutchinson M, Tubridy N. A delayed P3 event-related potential component correlates highly with cognitive impairment in multiple sclerosis. Neuroscience Ireland 2008.
€366,478. Co-applicant (July 2017), ILP-HSR-2017-005: "The relationship of medication adherence and environmental factors to exacerbations in patients with severe asthma"
Trinity Grant Award 2014, 2013, 2012.
This travel award, which allowed Isabelle to travel to Canada (2014) to attend the Joint Conference of the International Society of Posture and Gait Research and Gait and Mental Function (ISPGR/GMF), to Japan (2013) to attend two conferences: ISPGR/GMF and IEEE EMBC and Norway (2012) to attend ISPGR/GMF, was only made possible by the generosity of previous generations of graduates contributing to two sources of funding, the Graduate Studies Research Travel Fund and the Trinity Trust.
This travel grant allowed Isabelle to attend the Nineteenth Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland (Bini19).
Awarded by the Graduate Studies Office and Engineering Department, Trinity College Dublin. The selection of nominees from this award is based on academic merit. Awards are made to students who have demonstrated excellent academic abilities (with an emphasis on achievement during their postgraduate studies). Receipts of this award have their annual fees covered, along with receiving an annual maintenance grant of €8,000.
Best Poster in Section, Irish Gerontology Society Scientific Meeting, Kerry, Ireland (2016): "Risk Factors for Hospital Re-Admissions in Chronic Obstructive Pulmonary Disease" (Authors: Bennett, Cushen, Killane, Costello, Reilly).
Best poster, Trinity Centre for Bioengineering (TCBE) Christmas Symposium 2010, Trinity College Dublin, Ireland: "Gait and Cognition" (Authors: I. Killane, G. Browett, R.B. Reilly).
Journal of Gerontology: Series A (Medical Sciences).


The entrance gate of Gauhati University.
The Gauhati University has been granted 'A' grade by the National Assessment and Accreditation Council (NAAC). It has scored 3.04 (CGPA) on a four-point scale.
The university was last accredited 'B' grade by the NAAC in 2010, when it had scored a CGPA of 2.92. A team of NAAC members had carried out a thorough assessment of the university from May 22-24 this year.
The inspecting NAAC members had evaluated the university's research activities, infrastructure facilities, quality of students and faculties, amenities and academic and co-curricular activities.
A new methodology was adopted this time, with 70 per cent based on data provided by the varsity and 30 per cent based on visit by the NAAC team.
The accreditation to the varsity was recommended by the NAAC during its 66th standing committee meeting held today at Bengaluru. The validity of this accreditation status will remain for a period of five years with effect from Friday.


Whether you're feeling lucky or you're just plain hungry, the Buffs Club is the place to go. Officially the Carpentaria Buffalo Club, it's well known for its great atmosphere, top food and variety of facilities and services.
The Buffs Club is very community and family oriented. It has a kids club so if you're bringing a young family they'll enjoy the club experience as well.
The club is situated right on the main highway in the centre of town and is opem from 10.00am each day and from 8.00am on Sundays for a buffet breakfast.


Colonial Williamsburg will not present Under the Redcoat for 2017.
Colonial Williamsburg is going through many changes in how they plan to present and interpret history to the public. Until the effect of those changes is known, Colonial Williamsburg is holding off on re-introducing re-enactor events to the schedule.
Google Map to Bruton Heights.


A Guide to C Programming by Paul Kelly.
Related links, including how to purchase this book online, are on the navigation bar to the left.
A Guide to C++ Programming by Paul Kelly.
Related links, including how to purchase this book online, are on the navigation bar to the above left.


text:
Honest John Classics Ask Honest John » How much is a classic Mini that's had an engine swap worth?
How much is a classic Mini that's had an engine swap worth?
I'm looking to buy an 1989 Mini with 90,000 miles on the clock. The original 998cc engine has been replaced with an MG Metro 1275cc engine. It's in Immaculate condition and has had many extras fitted. What sort of money should I pay?
Asked on 13 February 2018 by Howard McQuaker
We haven't inspected the car, so we can't give you a definitive price - just a guide. Top money for one of these without the engine swap would be £4000-£5000. Whether or not it's worthy paying more for the engine swap, is something you'll have to decide for yourself. Has it been done well? Were the engine mounts replaced? Has the cooling system been upgraded? Was the clutch replaced at the same time (from memory the original bell housing won't fit), have the brakes been upgraded? How does it drive? Has the speedo been recalibrated? Check, check, and check again for rust. Mini are a hoot to drive and easy to get bits for, but keeping on top of the bodywork can be a full-time job.
Tags: engine replacement classic cars valuing a classic
How much is my 1999 Mini Cooper worth?
I have a 1999 Mini Cooper. It has done 32,000 miles. It's in very good, running condition. As with all old Mini, it's beginning to show a few signs of rust in the boot which will need repairing over the...
What is my restored 1927 Fiat 509 Spider cabriolet worth?
I'm busy with a full on restoration on a 1927 Fiat 509 Spider cabriolet. How many 509 Spider cabriolet were produced in their day? I've noticed that there's not a lot of these cars around anymore. What...
Should I restore my Jaguar XJ6 or sell it for parts?
I was restoring a 1974 4.2 Jaguar XJ6 - then its engine was stolen. Is it worth carrying on, or should I sell it for parts?
1986 Ford Capri Laser 2.0 Auto
1979 mg midget
1995 MG RV8 . 3.9 V8 . Woodcote Green. 35,000 Miles.


A123 Audio to MP3 AMR AAC OGG Converter is a powerful and easy to use audio conversion tool which can convert among MP3, AAC, AC3, AMR, M4A, OGG, WAV audio formats. It Batch conversion supported and you can convert more files within one time. With A123 Audio to MP3 AMR AAC OGG Converter, you will get any output formats you want with excellent quality.


The standard 240-volt portable-generator plug is a four-wire NEMA L14-30 plug that can be found in most hardware stores. The four wires consist of two "hot" wires (which are normally black but are sometimes red); a "neutral" wire (normally white); and a ground wire (usually green). To make your installation easier, check your generator owner's manual to ensure that a NEMA L14-30 will fit.
Remove the screws from the plug and remove the cover.
Use the knife to remove the outer covering on the cable, so the four inner wires are 1 1/2 inches in length.
Use the wire strippers to strip a half-inch of insulation off each of the four wires.
Loosen the screw connectors on each of the four prongs of the plug with a screwdriver.
Place the black wires under the screw connectors on the "hot" prongs and tighten them with a screwdriver.
Place the white wire under the screw connector on the "neutral" prong and tighten it with a screwdriver.
Place the green wire under the screw connector on the "ground" prong and tighten it with a screwdriver.
Replace the cover and tighten the screws with a screwdriver.


BORUSSIA DORTMUND boss Jurgen Klopp believes that Mats Hummels is good enough to play for Manchester United and revealed the defender is currently considering his future in Germany.
The Red Devils have been linked with a summer swoop for the Germany international, with Louis van Gaal believed to be on the search for a star centre-back.
Chelsea are also said to be interested in Hummels, but Klopp feels that his captain is leaning towards Old Trafford instead of Stamford Bridge.
He told DW Sport: "He's good enough for Manchester United. He's told me he's thinking things over.
"We're always looking around the market ourselves."