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"The cost-effective solutions from Isocom enhance our product portfolio and strengthen the optocoupler sector. The cooperation allows us to offer our customers even more choice to meet their specific demands," explains Reza Maghdounieh, Senior Marketing Manager Purchase and Line Management at Rutronik.


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Utility plans to build two natural gas power plants in Upper Peninsula
Thomas Content
The newest subsidiary of Wisconsin's largest utility company is seeking approval in Michigan to build two natural gas generation projects in Michigan's Upper Peninsula.
In an application filed Monday, the sister utility of We Energies said it wants approval for generation projects located in Baraga and Marquette counties, at a cost of $277 million.
Upper Michigan Energy Resources Corp. would build the natural gas generation projects, which would be built by 2019 and enable We Energies to shut down its coal-fired power plant in Marquette, Mich., in 2020.
"The filing is another significant step forwarding our commitment to a long-term viable solution for electric reliability in the U. P.," said J. Patrick Keyes, the former Wisconsin Energy chief financial officer who became president of UMERC when it formed Jan. 1.
Formation of the utility means Michigan residents, not Wisconsin utility customers, would have to pay for the plants.
The Michigan utility was formed to separate the Wisconsin and Michigan utilities of both We Energies and Wisconsin Public Service Corp. of Green Bay. Along with UMERC, they are subsidiaries of WEC Energy Group Inc., which was created when Wisconsin Energy bought Integrys Energy Group in 2015.
The natural gas generators would use a form of electric generation known as reciprocating internal combustion engines, which require limited water use compared with a conventional natural gas-fueled power plant.
If the projects are approved, construction would start late this year or early next year. The company is proposing a large plant, generating 120 to 150 megawatts, in Negaunee Township just north of the Tilden Mine, the biggest user of electricity in the peninsula. Also envisioned is a smaller plant, 35 to 55 megawatts, in Baraga Township in Baraga County.
Upper Michigan Energy Resources has 36,500 electric customers and 5,300 natural gas customers. A key customer for the project would be the Tilden Mine, an energy-intensive iron ore mine that is run by Cliffs Natural Resources Corp.
The utility is asking Michigan's Public Service Commission to approve a 20-year special power supply contract for the Tilden Mine as part of its application.
The natural gas pipeline serving the Upper Peninsula would need to be enhanced for the project, the utility says in its application. The utility has reached an agreement with pipeline company NNG to build a new compressor station and make other enhancements.
The mining company and We Energies have gone through a series of regulatory and legal skirmishes over the past five years, starting when the mining company — fed up by electricity rate hikes — replaced the Milwaukee utility with another power company under Michigan's partially deregulated utility system.
That move prompted We Energies to propose shutting down the coal plant in Marquette, which in turn led to customers across Michigan and Wisconsin paying We Energies to keep the plant running in order for the power grid in upper Michigan to remain stable.
The mining company and the WEC Energy came together to agree on the current plan, which calls for the Tilden mine to buy power from Upper Michigan Energy Resources under a long-term contract. At the same time, legal skirmishes over tens of millions of dollars of payments to We Energies continue to be waged in federal court in Washington, D.C.
Thomas Content can be reached at thomas.content@jrn.com or twitter.com/plugged_in

redpajama_set_name: RedPajamaCommonCrawl


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Space Battle Ship Yamato 2199 & 2202 Compilation Film Releases Full Trailer & Main Poster Visual
A special edition Blu-ray will also be released at the same time in theaters
November 19, 2020 10:10pm EST (11/19/20)
The official portal site for The Era of Space Battleship Yamato: The Choice of 2202 A.D., a new compilation film based on the two installments of the Space Battleship Yamato franchise - Space Battleship Yamato 2199 and Space Battleship Yamato 2202: Warriors of Love - has posted a 60-second full trailer and a main poster visual drawn by the character designer Nobuteru Yuuki (The Vision of Escaflowne, Heat Guy J).
The poster visual features Starsha, Queen of Iskandar, who reached out to the earth for help, and Teresa, a higher-dimensional being who has been praying for peace in the universe. This is the first time that the two beautiful goddesses have been featured together in the anime franchise's official promotional visual.
Full trailer:
Main poster visual:
The Era of Space Battleship Yamato is a 120-minute film edited by Harutoshi Fukui (Mobile Suit Gundam UC novel author), who served as the series composition writer for 2199 and 2202. From a new angle, the Apollo moon landing in 1969, the completion of the International Space Station in 2011, mankind's arrival on Mars in 2042, the voyage to Iskandar in 2199, and the Battle of Gatlantis in 2202 - all those episodes about the history of the space exploration and the space wars will be retold with newly recorded narrations.
The "rebuild" compilation film will get theatrical screenings in 36 theaters in Japan from January 15, 2021, for a limited time of three weeks. A special limited-edition Blu-ray disc will be sold in the theaters from the day of the film's screening, and its digital version will be also available on Amazon Prime Video and other platforms.
『宇宙戦艦ヤマト2199』と『2202』シリーズのポータルサイトをティザーオープンしました!https://t.co/9YiHkjVDqF
これから『宇宙戦艦ヤマト2205 新たなる旅立ち』最新情報なども含めて、こちらのサイトにも公開していきます#宇宙戦艦ヤマト#yamato2199#yamato2202#yamato2205
— 宇宙戦艦ヤマト2202製作委員会 (@new_yamato_2199) November 19, 2020
Source: "The Era of Space Battleship Yamato: The Choice of 2202 A.D." official portal site
© Yoshinobu Nishizaki/Space Battleship Yamato 2202 Production Committee
space battleship yamato 2202, space battleship yamato 2199, compilation film
The Melancholy of Haruhi Suzumiya Anime Website Teases A New "Activity"
Harajuku-born Short Sci-fi Web Anime Tokyo Gambo Starts Streaming in Japan Tomorrow
Crunchyroll Announces Streaming Plans For "Star Blazers: Space Battleship Yamato 2199" And More


GDPR stands for General Data Protection Regulation. It is a privacy law that will take effect on May 25, to update and complement legislation across the members of the European Union including U.K.
Specialists say that it will update laws from the mid-1990s and deal with privacy challenges by increasing transparency. After this date (May 25, 2018), GDPR will replace all the laws related to data protection as it will only be administered by GDPR.
All registered organisations in EU or have a subsidiary or establishment in EU are concerned. GDPR also applies to all organisations that sell goods and services to EU citizens and process their personal data.
Which parties are involved in GDPR?
What are the key changes ?
The encryption and pseudonymisation of personal data.
Confidentiality, integrity, availability, and flexibility of processing systems and services.
Restoration of the access to personal data in a timely manner, when a physical or technical incident happens.


These days, media specialists are gathering information not just from traditional offline sources but from the deep levels of online resources. In fact, in 2017, 42% of journalist surveyed across various countries stated they were already using digital data in their stories twice or more per week — indicating that this data is getting more and more important.
To support this trend, our media partnership service provides the appropriate tools to collect and deliver information or supplement the search of data for journalists, influencers, bloggers, editors, and other media professionals.
These tools are part of our Domain Research Suite (DRS) aimed to track website domains, monitor their behavior, and understand connections with other domains. They are useful in providing details about a particular entity as well as present a wealth of newsworthy insights into malicious online activities. Incidentally, there should be plenty of them for journalists to discover. By the first quarter of 2018, it was found that 11,135 domains had already been used for phishing.
In this article, we would like to talk about how our DRS products enable media professionals to expand their research methods.
The WHOIS Search tool is a crucial source of key data points regarding domains. Journalists can look up information in our WHOIS databases that contain 300 million active domain names and 5 billion historical WHOIS records. The data is organized and parsed in a consistent format for easy integration into journalists' research processes.
The service can provide various registration details related to domains, such as names of domain hosts, dates of domain changes, contact information, domain registrar information, and more.
This tool specializes in overseeing a domain's brand-related activities and might be useful both for journalists monitoring certain companies and individuals. It issues alerts whenever there are domain names that bear very close similarities to that of established companies. This comes in handy for professionals investigating possible copyright infringement.
Brand Monitor can also help foresee if a brand is planning to add a website to their extended line of products or services. Additionally, the monitoring could also be keyword-focused. Journalists concentrating on a targeted niche or industry can work with the raw information which is being gathered. Media influencers can get valuable updates when monitoring their competitions' domains by using this tool.
The process of searching domains in bulk could prove crucial for various research processes. For example, a domain can be compared with several other sites using the proven reliability of WHOIS records. If anything suspicious is detected about a target domain, such as its inconsistent contact details, this can be further investigated.
Websites claiming to have been in the industry for a long time but whose registrant details, such as domain dates, don't add up, could provide interesting leads.
There are more ways in which the Bulk WHOIS search tool can be used either for the media company's own business use, a practitioner's personal branding efforts, or for gathering information to produce a story.
This is a practical tool for those media professionals who want to stay updated on an individual or an organization they have been eyeing discreetly.
Domain registrant's details like their name, telephone number, email, and address could be the starting point for research. One can also use the Registrant Alert to get real-time notifications about a target domain owner. Activities of a particular registrant such as adding or removing domains and other important information are also forwarded to the researcher.
Specific details about a target registrant can be inputted into the tool to see what other sites the individual might own or have owned. Inconsistent details such as the variation of host names for different sites can provide clues about the entity's activities.
Much like the concept of reverse engineering, journalists can use the Reverse WHOIS Search tool to check the details about a certain domain and its connections in different ways. One can use this product's filters to input only specific details when conducting searches. It is also possible to use both the fuzzy match and exact match features.
Moreover, historic records for both active and inactive domains can be examined, allowing researchers to check the patterns of activities in these domains — including potentially fraudulent ones.
The Domain Monitoring and Domain Availability tools deal with presenting the changes and the availability of certain domains. Media practitioners can navigate them for various purposes. For instance, they can be a starting point for their research if they want to confirm the existence and the nature of any domain. These tools can also serve the personal branding purposes of a media company or a professional.
The world of domain names and its numerous connections is a treasure trove of information which journalists can find invaluable in creating engaging stories. If you are a media professional ready to look for materials in the digital realm, then contact us at support@whoisxmlapi.com to learn more about our Domain Research Suite (DRS) and media partnership services.


First, let me say, that I really enjoy this book. It's practical, answers questions that are bound to come up if one writes for any amount of time, and it explains *why* certain principles have been developed. This is actually something I struggled with in my last article, and am still struggling with as I revise. My last article was about some misconceptions people had about a certain cultural practice. Two people really verbalized what everyone else was dancing around in their quotes, but I think these people also knew that they were not fully informed on the subject, and neither wanted to be named in the piece. This was before I had read these chapters, and I didn't see the harm in having an anonymous source.
However, as Haiman explains, if someone is quoted insulting another person, the insulted party has a right to know who is making such claims. Also, if the story rests on an anynonmous quote, it tends to lose its sense of reliability. An anynomous quote simply doesn't carry the same weight as a quote given by someone in the community, or, even better, a nationally recognized name. These three guidelines that Haiman lists on page 19 may not be infallible, but they certainly leave journalists with more to go with than before. Any time there is one set of rules that many can look to, there are fewer excuses for straying from the path.
Greta talks about some ways to make sure, when you get a quote *and* a name, you get the quote right. You don't want people afraid to give you quotes, do you?
I also find this book helpful/informative. Much more so than some other books I have read. I understand how it seems that the article loses weight when there's an anonymous quote. That's why I wish people just trusted other people and that people were good. This way everyone would know the quote isn't made up and some authority said it. That authority just doesn't want to get in trouble or something.
I blogged about the same topic as you and the anonymous sources/quotes. I really like how you mentioned that if a story bases its self on an anynomus quote, then it will lose some of its reliability. I think that this is very true because the audience would not know where the information came from. I also agree with you that some people do not want to be quoted on the subject or topic because they are not that educated on it, but want to provide what they know. Good blog and insight!
But What Cometh Before Pride?
The Opposite of Irony? Wrinkly.


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Excellent training and to the point. The trainer had a broad experience in the field of BCP that made the syllabus more vivid. The logistics part was also very well organised.


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Home Business Dangote is focused on growing Ghana's economy – MD
Dangote is focused on growing Ghana's economy – MD
The Dangote Group of Companies are focused on contributing to the economic growth of Ghana through job creation and the payment of taxes and would, therefore, not be drawn into any smear economic campaign.
"Within only six years of operating here in Ghana, we have, as of today, over 2,000 workforce on our payroll," he said.
"The figure does not include the 2,400 drivers' mates that assist our drivers on the road and the over 20,000 people who are indirectly benefitting from our operations in Ghana."
Mr Tor Nygard, the Managing Director of Dangote Ghana, announced this at a media conference in Tema to outline their contributions to Ghana's economy and refute some allegations their competitors had levelled against them.
He said apart from being the largest employer in the cement industry, the introduction of Dangote cement into the Ghanaian market six years ago, had stabilised the prices of the commodity on account of the competitive prices they provided to the Ghanaian consumer.
Mr Nygard said:"Ghacem and Diamond cement boast of contributing to the economy of Ghana by employing a large number of Ghanaians. For almost 50 years of their operations, Ghacem and Diamond cement together employ less than 3,000 people."
He said the customers patronised their products based on quality, competitive prices, reliability of delivery and customer service and they would not allow their competitors to derail their orderly progress in that sector.
"This is where our focus is, and the market noticed the effect of our entry in the Ghanaian market resulting in a stable and even reduced price in the market. We are not participating in smear campaign about our competitors, which seems to be their main focus."
Mr Nygard said they would rather continue with their expansion programme, a virtue, he said, had urged them on to dole out $100 million in the establishment of a new grinding plant in Takoradi, expected to be completed by the end of 2017.
The Managing Director appealed to Ghanaian media to remain resolute and fair in the handling of advertisements of various cement companies, as they had gathered some information that their competitors were trying to influence the refusal of their advertisements in some media outlets.
On value addition, Mr Nygard said apart from supplying and transporting bulk cement, which required specially required silos, they also bagged cement for distribution to the market with environmental control measures to avoid fugitive emissions.
"If we do not add value, what will we be doing with over 700 workers that operate just at the plant alone," the Managing Director asked?
Mr Nygard said as the highest grade cement producer in the country, Dangote Cement would continue to ensure price stability, expand to meet growing demand, employ more people and operate within the laws of Ghana and support economic growth.
Dangote Cement Ghana Limited started operations in Ghana on February 10, 2010, as a cement bagging plant ironing bulk cement from outside the Economic Community of West African States.
Apart from the $55 million bagging plant, Dangote has also purchased 1,000 new trucks at $82 million to help in the free delivery of their products to customers throughout the country.
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Ezra Brooks is a brand of Kentucky straight bourbon whiskey. It is primarily bottled at 40% abv (80 U.S. proof) or 45% abv (90 U.S. proof).

The Ezra Brooks brand was created by Frank Silverman in 1957 and was bottled at the Hoffman Distilling Company, in Lawrenceburg, Kentucky, up until Hoffman Distilling Co. went out of business in the 1970s. In 1993, Ezra Brooks was purchased by Luxco of St. Louis, Missouri (formerly the David Sherman Company, renamed in 2006). Ezra Brooks is distilled at Luxco's Lux Row Distillers in "bourbon county" Bardstown, Kentucky, along with Luxco's other whiskey brands Rebel Yell , David Nicholson, and Blood Oath.

Varieties
Ezra Brooks Black Label Kentucky Sour Mash
Ezra Brooks 99 (99 proof)
Old Ezra (101 proof, aged 7 years)
Ezra Brooks  Blended Whiskey (80 proof)
Ezra Brooks Bourbon Creme (25 proof)
Ezra B Single Barrel (99 proof, 12 years old) – No longer produced
Ezra Brooks Cinnamon liqueur (70 proof) – No longer produced
Ezra Brooks Straight Rye Whiskey (90 proof) aged 24 months

In films
A billboard advertising the Ezra Brooks brand was featured in the film The Sting. This was an anachronism, however. The film was set in 1936 while the Ezra Brooks brand would not appear for another 20 years.
In the film Léon: The Professional, Gary Oldman's Character, Stansfield, picks up a bottle of Ezra Brooks whiskey in Mathilda's apartment.
In the Japanese anime series Trigun season 1: episode 3 at 6:01, you can see a bottle of Ezra Brooks laying on the ground as the camera pans away from Vash and the drunkard.

References

Bourbon whiskey

redpajama_set_name: RedPajamaWikipedia


Grab Giro's Candela 2 Gloves for riding in cold, wet, windy weather. With water-resistant, 3-layer soft shells, the breathable uppers boast antimicrobial fleece liners and wind-proof exteriors, and the insulated cuffs transfer moisture and sport secure closures. The 3-piece, bunch-free palms feature Clarino synthetic leather and 3mm-thick EVA padding for protection. Plus, reflective accents enhance visibility, fingertip silicone improves grip and Giro's Super Fit ergonomics deliver a custom fit and feel.
All-mountain riding demands gear that is versatile, lightweight without sacrificing durability, and comfortable enough to ride all day in varying conditions. So Giro developed the Xar specifically for this kind of trail riding, with features like 17 Wind Tunnel vents with internal airflow channels, the micro-adjustability of Roc Loc 5 and their patented P.O.V. visor to deflect the sun, rain, brush and branches. If you're riding farther than ever into the wilderness, the Xar is fit to roll with you.


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The US has a joint federal and state system for regulating insurance, with the federal government ceding primary responsibility to the states under the McCarran-Ferguson Act. States regulate the content of health insurance policies and often require coverage of specific types of medical services or health care providers.[54][55] State mandates generally do not apply to the health plans offered by large employers, because of the preemption clause of the Employee Retirement Income Security Act.
Today, this system is more or less intact. All citizens and legal foreign residents of France are covered by one of these mandatory programs, which continue to be funded by worker participation. However, since 1945, a number of major changes have been introduced. Firstly, the different health care funds (there are five: General, Independent, Agricultural, Student, Public Servants) now all reimburse at the same rate. Secondly, since 2000, the government now provides health care to those who are not covered by a mandatory regime (those who have never worked and who are not students, meaning the very rich or the very poor). This regime, unlike the worker-financed ones, is financed via general taxation and reimburses at a higher rate than the profession-based system for those who cannot afford to make up the difference. Finally, to counter the rise in health care costs, the government has installed two plans, (in 2004 and 2006), which require insured people to declare a referring doctor in order to be fully reimbursed for specialist visits, and which installed a mandatory co-pay of €1 for a doctor visit, €0.50 for each box of medicine prescribed, and a fee of €16–18 per day for hospital stays and for expensive procedures.
Supporters of a public plan, such as Washington Post columnist E. J. Dionne, argue that many places in the United States have monopolies in which one company, or a small set of companies, control the local market for health insurance. Economist and New York Times columnist Paul Krugman also wrote that local insurance monopolies exist in many of the smaller states, accusing those who oppose the idea of a public insurance plan as defenders of local monopolies. He also argued that traditional ideas of beneficial market competition do not apply to the insurance industry given that insurers mainly compete by risk selection, claiming that "[t]he most successful companies are those that do the best job of denying coverage to those who need it most."[20]
In-Network Provider: (U.S. term) A health care provider on a list of providers preselected by the insurer. The insurer will offer discounted coinsurance or co-payments, or additional benefits, to a plan member to see an in-network provider. Generally, providers in network are providers who have a contract with the insurer to accept rates further discounted from the "usual and customary" charges the insurer pays to out-of-network providers.
Health insurance is a type of insurance coverage that pays for medical and surgical expenses incurred by the insured. Health insurance can reimburse the insured for expenses incurred from illness or injury, or pay the care provider directly. It is often included in employer benefit packages as a means of enticing quality employees. The cost of health insurance premiums is deductible to the payer, and the benefits received are tax-free.
The 1960 Kerr-Mills Act provided matching funds to states assisting patients with their medical bills. In the early 1960s, Congress rejected a plan to subsidize private coverage for people with Social Security as unworkable, and an amendment to the Social Security Act creating a publicly run alternative was proposed. Finally, President Lyndon B. Johnson signed the Medicare and Medicaid programs into law in 1965, creating publicly run insurance for the elderly and the poor.[29] Medicare was later expanded to cover people with disabilities, end-stage renal disease, and ALS.
Beginning with 10% of blue-collar workers in 1885, mandatory insurance has expanded; in 2009, insurance was made mandatory on all citizens, with private health insurance for the self-employed or above an income threshold.[23][24] As of 2016, 85% of the population is covered by the compulsory Statutory Health Insurance (SHI)[25] (Gesetzliche Krankenversicherung or GKV), with the remainder covered by private insurance (Private Krankenversicherung or PKV) Germany's health care system was 77% government-funded and 23% privately funded as of 2004.[26] While public health insurance contributions are based on the individual's income, private health insurance contributions are based on the individual's age and health condition.[23][27]
Coverage from a health insurance policy or a public health program can greatly relieve the financial burden of health care expenses due to Cerebral Palsy. Those who are uninsured or underinsured can experience financial strain and require assistance from alternative funding sources such as community groups, charity organizations, or local business establishments. When no health insurance exists, providers often request payment in advance of services, or a payment plan agreement.
Foreseeing a long and costly political battle, many labor unions chose to campaign for employer-sponsored coverage, which they saw as a less desirable but more achievable goal, and as coverage expanded the national insurance system lost political momentum and ultimately failed to pass. Using health care and other fringe benefits to attract the best employees, private sector, white-collar employers nationwide expanded the U.S. health care system. Public sector employers followed suit in an effort to compete. Between 1940 and 1960, the total number of people enrolled in health insurance plans grew seven-fold, from 20,662,000 to 142,334,000,[26] and by 1958, 75% of Americans had some form of health coverage.[27]
Hospital and medical expense policies were introduced during the first half of the 20th century. During the 1920s, individual hospitals began offering services to individuals on a pre-paid basis, eventually leading to the development of Blue Cross organizations in the 1930s.[19] The first employer-sponsored hospitalization plan was created by teachers in Dallas, Texas in 1929.[20] Because the plan only covered members' expenses at a single hospital, it is also the forerunner of today's health maintenance organizations (HMOs).[20][21][22]
In January 2013, Representative Jan Schakowsky and 44 other U.S. House of Representatives Democrats introduced H.R. 261, the "Public Option Deficit Reduction Act", which would amend the Affordable Care Act to create a public option. The bill would set up a government-run health insurance plan with premiums 5% to 7% percent lower than private insurance. The Congressional Budget Office estimated it would reduce the United States public debt by $104 billion over 10 years.[12] Representative Schakowsky reintroduced the bill as H.R. 265 in January 2015, where it gained 35 cosponsors.[13]
^ Leichter, Howard M. (1979). A comparative approach to policy analysis: health care policy in four nations. Cambridge: Cambridge University Press. p. 121. ISBN 978-0-521-22648-6. The Sickness Insurance Law (1883). Eligibility. The Sickness Insurance Law came into effect in December 1884. It provided for compulsory participation by all industrial wage earners (i.e., manual laborers) in factories, ironworks, mines, shipbuilding yards, and similar workplaces.
How to Enroll: Individuals who need coverage can fill out a single application to find out what financial assistance they are eligible for and to apply for coverage. To find your state's Marketplace and to apply online go to www.healthcare.gov. Individuals can also call toll-free 1-800-318-2596 to apply. Those needing assistance with filling out the application can get help from trained, certified counselors; to find in-person assistance near you, contact your state's Marketplace or visit www.healthcare.gov.
Hospital and medical expense policies were introduced during the first half of the 20th century. During the 1920s, individual hospitals began offering services to individuals on a pre-paid basis, eventually leading to the development of Blue Cross organizations.[65] The predecessors of today's Health Maintenance Organizations (HMOs) originated beginning in 1929, through the 1930s and on during World War II.[67][68]
The public option was featured in three bills considered by the United States House of Representatives in 2009: the proposed Affordable Health Care for America Act (H.R. 3962), which was passed by the House in 2009, its predecessor, the proposed America's Affordable Health Choices Act (H.R. 3200), and a third bill, the Public Option Act, also referred to as the "Medicare You Can Buy Into Act", (H.R. 4789). In the first two bills, the public option took the form of a Qualified Health Benefit Plan competing with similar private insurance plans in an internet-based exchange or marketplace, enabling citizens and small businesses to purchase health insurance meeting a minimum federal standard. The Public Option Act, in contrast, would have allowed all citizens and permanent residents to buy into a public option by participating in the public Medicare program. Individuals covered by other employer plans or by state insurance plans such as Medicare would have not been eligible to obtain coverage from the exchange. The federal government's health insurance plan would have been financed entirely by premiums without subsidy from the Federal government,[3] although some plans called for government seed money to get the programs started.[4]
As of 2014, more than three-quarters of the country's Medicaid enrollees were covered under private Medicaid managed care plans, and 31 percent of Medicare beneficiaries were enrolled in private Medicare Advantage plans in 2016. However, the funding for these plans still comes from the government (federal for Medicare Advantage, and a combination of state and federal funding for Medicaid managed care).
Broader levels of health insurance coverage generally have higher premium costs. In many cases, the insured party is responsible for paying his/her healthcare provider an up-front, tax deductible amount called co-pay. Health insurance companies then may compensate healthcare providers directly or reimburse the policy holder based on the remaining portion of an itemized bill.
Ultimately, the public option was removed from the final bill. While the United States House of Representatives passed a public option in their version of the bill, the public option was voted down in the Senate Finance Committee[8] and the public option was never included in the final Senate bill, instead opting for state-directed health insurance exchanges.[9] Critics of the removal of the public option accused President Obama of making an agreement to drop the public option from the final plan,[10] but the record showed that the agreement was based on vote counts rather than backroom deals, as substantiated by the final vote in the Senate.[11]
Research available health insurance providers. Does a parent's employer offer insurance plans? If so, when is enrollment and what are the options? Does the parent belong to any clubs, special interest groups, or organizations that offer health insurance? Are they eligible and approved for any government insurance plans? Do they want to pursue an independent provider?
Finally achieving universal health coverage remained a top priority among Democrats, and passing a health reform bill was one of the Obama Administration's top priorities. The Patient Protection and Affordable Care Act was similar to the Nixon and Clinton plans, mandating coverage, penalizing employers who failed to provide it, and creating mechanisms for people to pool risk and buy insurance collectively.[9] Earlier versions of the bill included a publicly run insurer that could compete to cover those without employer sponsored coverage (the so-called public option), but this was ultimately stripped to secure the support of moderates. The bill passed the Senate in December 2009 with all Democrats voting in favor and the House in March 2010 with the support of most Democrats. Not a single Republican voted in favor of it either time.
Over time, the operations of many Blue Cross and Blue Shield operations have become more similar to those of commercial health insurance companies.[101] However, some Blue Cross and Blue Shield plans continue to serve as insurers of last resort.[102] Similarly, the benefits offered by Blues plans, commercial insurers, and HMOs are converging in many respects because of market pressures. One example is the convergence of preferred provider organization (PPO) plans offered by Blues and commercial insurers and the point of service plans offered by HMOs. Historically, commercial insurers, Blue Cross and Blue Shield plans, and HMOs might be subject to different regulatory oversight in a state (e.g., the Department of Insurance for insurance companies, versus the Department of Health for HMOs). Today, it is common for commercial insurance companies to have HMOs as subsidiaries, and for HMOs to have insurers as subsidiaries (the state license for an HMO is typically different from that for an insurance company).[19][95][103] At one time the distinctions between traditional indemnity insurance, HMOs and PPOs were very clear; today, it can be difficult to distinguish between the products offered by the various types of organization operating in the market.[104]


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Daily Email Newsletter
Vice President Pence Says North Korea Should Not Test U.S. Resolve
Posted by Michael Burg on Apr 17th, 2017
On Monday, United States Vice President Mike Pence warned North Korea it could receive the same treatment as Afghanistan and Syria, both of which the White House bombed recently, if it were to continue with its nuclear testing program.
The stern warning, delivered by the vice president in Seoul following his visit to the demilitarized zone that separates North and South Korea, could spark speculation that the Trump administration is contemplating military action against the Pyongyang regime.
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Pence said the White House administration wants to convince the North Koreans to abandon their nuclear weapons via peaceful means. However, he repeated the warning by the administration that all options remained on the table.
Pence arrived in Seoul only hours after the most recent ballistic missile launch by North Korea. The missile exploded within seconds of blast off. The weekend also included much fanfare across North Korea as the regime paraded what looks to be new missiles designed to reach the U.S.
During his trip to the zone between to two Koreas, and later during remarks to the media, Pence issued his strong warnings to North Korea.
He said in only the last two weeks, the world has witnessed the resolve and strength of our new U.S. president in actions taken in Afghanistan and Syria.
He added that North Korea should not test the president's resolve or the strength of the U.S. armed forces in the area.
Earlier in April, on the command of Trump, the military launched cruise missiles (59) at a military airfield in Syria as retaliation for the chemical attack that killed dozens of civilians.
Less than one week later, the military dropped a bomb that weighed 22,000 pounds, which is the largest bomb that is non-nuclear ever used by the U.S. in combat, on forces from the Islamic State in Afghanistan.
Any potential military strikes against North Korea would likely bring diplomatic crisis for the U.S. with China, which is a main economic lifeline of North Korea.
Both U.S. Secretary of State Rex Tillerson along with Pence stated that the strategic patience from the Obama policy of pressuring North Korea is over and military action is now a viable option to make North Korea shut down its nuclear program.
The decision by the U.S. Navy to reroute a strike group on an aircraft carrier to the region as tensions increased has also fueled more speculation the White House might make a pre-emptive strike on military facilities in North Korea.
Trump's Back and Forth on Economics
Jon Ossoff Misses Outright Victory in House Race in Georgia
Advance Auto Parts, Inc. Receives Consensus Rating of "Buy" from Analysts
Pioneer Natural Resources Given Consensus Recommendation of "Buy" by Brokerages
Pioneer Natural Resources Receives Average Rating of "Buy" from Brokerages
Huntington Ingalls Industries, Inc. Shares Sold by TD Asset Management Inc.
Celldex Therapeutics, Inc. Shares Acquired by TD Asset Management Inc.
Raymond James Financial Services Advisors Inc. Has $552,000 Stock Position in AGNC Investment Corp.
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Advance Auto Parts, Inc. (NYSE:AAP) Receives Consensus Rating of "Buy" from Analysts
Pioneer Natural Resources (NYSE:PXD) Given Consensus Recommendation of "Buy" by Brokerages
Pioneer Natural Resources (NYSE:PXD) Receives Average Rating of "Buy" from Brokerages
Huntington Ingalls Industries, Inc. (NYSE:HII) Shares Sold by TD Asset Management Inc.
Celldex Therapeutics, Inc. (NASDAQ:CLDX) Shares Acquired by TD Asset Management Inc.
Raymond James Financial Services Advisors Inc. Has $552,000 Stock Position in AGNC Investment Corp. (NASDAQ:AGNC)
State Board of Administration of Florida Retirement System Cuts Stake in KBR, Inc. (NYSE:KBR)
Hercules Capital, Inc. (NYSE:HTGC) Shares Bought by Raymond James Financial Services Advisors Inc.
Deutsche Bank AG Lowers Position in Nexstar Media Group, Inc. (NASDAQ:NXST)
State Board of Administration of Florida Retirement System Increases Holdings in ShockWave Medical, Inc. (NASDAQ:SWAV)
State Board of Administration of Florida Retirement System Has $2.23 Million Stock Holdings in ADTRAN, Inc. (NASDAQ:ADTN)
State Board of Administration of Florida Retirement System Has $2.88 Million Position in BJ's Wholesale Club Holdings, Inc. (NYSE:BJ)
Advanced Drainage Systems, Inc. (NYSE:WMS) Stock Position Increased by State Board of Administration of Florida Retirement System
State Board of Administration of Florida Retirement System Lowers Stake in Hilltop Holdings Inc. (NYSE:HTH)
Mackenzie Financial Corp Purchases 2,051 Shares of Clearway Energy, Inc. (NYSE:CWEN)
Insider Selling: Sono-Tek Co. (OTCMKTS:SOTK) VP Sells $45,265.00 in Stock
Insider Buying: TELA Bio, Inc. (NASDAQ:TELA) Insider Acquires 5,000 Shares of Stock
Swiss National Bank Increases Stake in Arena Pharmaceuticals, Inc. (NASDAQ:ARNA)
Russell Investments Group Ltd. Has $5.54 Million Stake in Grocery Outlet Holding Corp. (NASDAQ:GO)
Raymond James & Associates Has $1.68 Million Holdings in Phibro Animal Health Co. (NASDAQ:PAHC)
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Kim: Hey, Ron, can't stop. Busy.
Kim: Oh, it'll be ready. Will you?
organising the clean-up of Middleton Park.
Kim: No big. It will be beyond spotless.
the Mad Dog ball, are we on track?
Girl#2: You know someone who met Smash Mouth's persal trainer?
Kim: Nice try, Bonnie, but everything's under control.
Kim: What's the sitch, Wade?
Bonnie: Oh, yes, this it what I call totally under control.
Ron: Maybe it's time to cut back on extra-currics.
Kim: Don't have to. I can do it all.
Ron: Why not be more like me... relaxed, laid-back.
the bathroom once a week.
Kim: Any more fun sloth facts?
mass-produced with love thanks to the most powerful engine.
Guide: I see we have some stragglers.
Guide: The engine! Where's the engine?!
Kim: Morning, Mom, gotta go.
Kim's Mom: Oh, no. You're not running out without eating fast.
Kim's Dad: If you ask me, kids today are way overschedged.
Kim: Dad, didn't we agree on no life lessons at breakfast?
saving up for a Britina doll, but the store ran out.
Kim: Don't mean to sound Scroogie, Wade, but one girl, one doll.
Kim: OK. I'm on it.
Girls: ( Chant ) We want Britina! We want Britina!
Man: Try to be understanding you cute, cute little girls.
Girls: ( Chant ) We want Britina!
Man: I don't have any!
Kim: I think you missed one.
Kim: How long has this been going on?
Ron: Um, is that your car out there?
Wade: Engine theft at the factory. I see. Hmmm, it gets weird.
Kim: Oh, great. I don't have time for weird.
Kim: Just like last week's conveyor belt heist.
Wade: Could be somebody's building thier own assembly line.
Ron: It's for little Midge!
decorating troops at the gym.
list. Luckily, I've got the whole thing worked out.
Ron: I'm not sure that look working for you, KP.
Kim: I didn't have time to find people for the park clean-up.
Bonnie: Your decorations? I didn't know recycling was the theme.
put it on paper yet, but it's all up here.
Kim: Oh, hold that thought. Wade, can't the sitch sit?
Wade: You got a hit from a brand new mannequin factory in Sweden.
process a dummy a minute.
this is a delicate time.
Kim: OK, we're on our way.
Kim: Um, sorry you guys, but I have to go.
again? You're the chair why?
Kim: Trust me. I'll be back in a flash.
Bonnie: Great. I might fill the time running down my plan.
Kim: Oh, that Bonnie! She is the bossiest person on the planet.
Ron: Bold statement, KP. It's a big planet.
Man: Miss Possible, thank you for coming so quickly.
Kim: Don't worry, sir. If the thieves show, we'll get 'em.
Ron: They can't defeat the Stoppable knot manoeuvre.
Ron: This baby's not going anywhere!
Kim: That didn't take long.
Ron: Did I miss something?
Kim: We all missed something.
Ron: Foiled in a dummy factory. This doesn't look good.
Ron: Kim! This just isn't working!
Rufus: ( Grunts ) Gross!
Kim: Try, you guys, that Sweden trip torched my schedule.
Ron: Or you could just learn to say "no".
Kim: I'm not programmed that way, Ron.
Ron: Really, it's not that hard. Try it with me now. OK, ready?
Kim: Don't need the instant replay, lived it.
Kim: Wade, freeze it there.
Ron: Do we know them?
Kim: It's the Bebe Robots.
Ron: Wade, didn't you kick their cans?
Bebe: The Bebe assembly line is almost perfected.
Bebe: The Bebe's hive will grow.
Bebe: The only one to defeat Bebes is Kim Possible.
Kim: "Oh, that Bonnie! She is the bossiest person on the planet."
Bebe: A queen... Bebe's need queen.
Bebe: We must seek out this one called Bonnie.
Bonnie: Freddie, can you get Smash Mouth? No?!
upgrade. I'm going to need help.
TV: A hive is city for bees. Bees reproduce in the hive.
Wade: I might have an idea. Can you meet me after school?
TV: Enterprise is run by the queen who is selected by the workers.
Kim: Are you watching this?
Ron: Just barely. The production values are way below Ghost Car.
Ron: I can't believe it.
Ron: No! That we finally get to meet Wade in the flesh!
bails at the last minute.
Ron: So, where is he?
Ron: Oh, man! I thought this was gonna be historic!
Kim: It will happen some day.
Wade: I've been doing some consulting work on movement dynamics.
Kim: Er, Wade, it's a rat in a maze.
Ron: Yeah, a slow rat.
Wade: Right. This is the control group without speed enhancement.
Ron: Way to be, Rufus!
Wade: And now the experimental subject.
Ron: That is one speedy rodent!
Ron: Right, right. Obviously. ...What's that mean?
Kim: No time. They're my best hope of catching the speedy Bebes.
don't understand all the effects the shoes you have.
Kim's Dad: ( o.s. ) Kimmy!
Kim: Oh, yeah, this I could get used to.
Kim's Dad: Honey, you need a ride to school?
Kim: No thanks, Dad. Got it covered.
Ron: KP, you're wearing the super shoes.
Kim: You think I shouldn't be taking the risk. That's sweet.
Kim: Come on. We've got a schedule.
Kim: You hang. I'll decorate.
Kim: All done. No big.
Kim: ( Speaks quickly ) What up, Wade? Got the 411 on the Bebes?
If you know where, I am there.
Wade: You've been wearing the shoes?
that's suddenly appeared on an island off the Gulf coast.
Kim: Super-speed construction? A hive. Let's jet.
Kim: Thanks for the lift, Joe.
Joe: ( Speaks slowly ) It's the least I can do.
Kim: ...me. I'm moving at hyper-speed.
Kim: Ugh! Oh. Uh-oh. Ugh! Come on!
standing still. Ron can't even hear me.
Ron: ( Reading ) "Ron, moving at hyper speed. Went ahead. Kim."
Huh, must be the shoes.
Kim: This must be the place.
Bebe: Bebe 16 accessing hive.
Bebe: Kim Possible. You are so done-for.
Kim: Bonnie is your queen?
Bebe: Thanks to you, Kim.
Bebe: The Bebe hive mind is so Bonnie.
Kim: OK, enough. A hyper-sonic emission got you last time.
Bebe: I don't think so.
Bebe: Fool me twice and all that.
Bebe: Wearing that? How tacky.
Kim: I have a dress!
queen, Bonnie, will be perfect and take over your species.
Kim: You can't even see me.
Ron: Kim, are you here?
Bonnie: They let you out of the dummy factory?
Ron: Bonnie, you're their queen?!
Bonnie: This is so totally Kim's fault! Where is she?
Ron: She's moving at hyper speed just like the Bebes.
Kim: OK, yes. Defying gravity does rock.
Ron: What are you doing in that thing?
I order them to put me down they just said, "Bonnie rules."
Which, you know, I had to agree with.
Bonnie: Just crack this thing open and get me out.
Ron: You did that on purpose!
Ron: Rufus, the shoes! You can help Kim.
Ron: Run! Run like the wind, little mole rat.
Bebes: Give her a ride on the conveyor belt.
Kim: I would really rather not get Bebefied.
Bebe: Bebes, we've got to destroy that hairless freak.
Kim: Now, these odds I like.
Kim: Three up. Three down.
Bebe: What are you talking about?
Bebe: No! Bebes must be perfect! Lik Queen Bonnie is perfect.
Bebes: Bebes must be perfect.
Ron: Way to go, KP!
Bonnie: Kim, this is all your fault.
Ron: You're probably talking too slow for her to hear you.
Kim: I guess I have to let her out.
Ron: Bonnie, Kim must have set you free.
Bonnie: She got me into this. Now how are we gonna get home?
Ron: Another note. KP's doing something.
Queenie." And what is that supposed to mean?
Kim: Let's go to the dance... I hope.
Steve Harwell: I'm not sure how we got here, but let's party!
% Smash Mouth performs "Come On Come On"
what it looks like when someone really delivers.
Kim: Only missed the dance by a thousand miles that time.
Kim: OK, now, even slower.
Kim: I'm sure the shoes will come off... eventually. Wanna dance?


text:
Oxidoreductases
Dehydrogenases
Based on 14 reference(s) in Google Scholar 10 10 14
MF C19H18N4OS
Purity: 100%
Soluble in DMSO and Ethanol
Antagonist of Hedgehog (Hh) signaling (IC50 value of 30 nM for inhibition of Gli-dependent transcriptional activity) and a potent inhibitor of microtubule assembly that exhibits good antiproliferative activity both in vitro and in vivo. JK184 appears to act by inhibition of Adh7 (Kd value 210 nM in a assay for enzymatic oxidation of retinol).
KEYWORDS: JK184 | supplier | Hedgehog inhibitor | JK-184 | CAS [315703-52-7] | [466638-53-9] | Hedgehog | ADH | Antagonist | Hh | Smoothened | Smo | Patched | Ptch1 | Ptc | Gli | microtubules | Sonic | shh | Indian | ihh | Desert | dhh
J Lee et al. A small-molecule antagonist of the hedgehog signaling pathway. Chembiochem. 2007 Nov 5;8(16):1916-9.
T Cupido et al. The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling. Angew Chem Int Ed Engl. 2009;48(13):2321-4.
Cell Signaling & Oncology Epigenetics Stem Cell Hedgehog ADH EC 1.1.1.1
Hedgehog (Hh) signaling pathway antagonist with antiproliferative activity
N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
10 mg €80.00 In Stock 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50
1500 GDC 0449 Hedgehog (Hh) pathway inhibitor €80.00
1619 NVP-LDE225 Smoothened (SMO) antagonist €85.00
1690 Purmorphamine Hedgehog signaling pathway activator €110.00
2035 RU-SKI 43 hydrochloride Hedgehog acyltransferase (HHAT) inhibitor blocks Shh signaling €105.00
2196 LY 2940680 Small-molecule antagonist of the Smoothened (SMO) receptor €120.00
2356 BMS 833923 Oral antagonist of the Hedgehog signaling component Smoothened (SMO) €75.00
2642 GANT61 Inhibitor of GLI-mediated transcription and Hedgehog (Hh) signaling €120.00
2673 RUSKI-201 dihydrochloride Sonic HHAT inhibitor lacking off-target cytotoxicity €135.00