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Over 1,600 workers to lose job at Illinois Jeep Cherokee factory due to worsening semiconductor shortage
Ramon TomeyMay 28, 2021
Natural News) More than 1,600 workers are about to lose their jobs at a Jeep Cherokee factory in northern Illinois as the global shortage of semiconductors continues to plague automakers.
The U.S. arm of Stellantis automotive company announced on May 14 that it would cut one of the two work shifts at its Belvidere Assembly Plant beginning July 26. The plant has been idle since late March and its re-opening has been delayed and isn't expected until "at least" later this month.
Jodi Tinson, a spokeswoman for the company, said it could result in the layoff of as many as 1,641 workers. She claimed that the company is trying to "balance sales with production" and that the factory's situation "has been further exacerbated by the unprecedented global microchip shortage." (Related: Top selling vehicles are being held back, made without computers as semiconductor shortage sweeps the globe.)
This statement is at odds with comments made earlier this month by the company's Chief Financial Officer Richard Palmer, who said that while the "semiconductor shortage impact would be higher in Q2, it would still be "very controlled."
Stellantis's Q1 revenues up by 14 percent from last year
Despite the drop in production because of the semiconductor shortage, Stellantis reported earlier this month a 14 percent increase in first-quarter revenues. The company's revenues for the first three months of 2021 were 36.9 billion euros ($45.1 billion), compared with 32.4 billion euros ($39.6 billion) in the first three months of last year.
Stellantis was created from the merger of Fiat Chrysler Automobiles and PSA Peugeot, which became official on Jan. 17 and created the world's fourth-largest carmaker. The figures took into account the individual performances of Fiat Chrysler and PSA Peugeot in the preceding periods.
Lost production due to the global chip shortage for the period was 190,000 vehicles, Palmer said. Eight of the company's 44 plants are currently affected, leading to reductions in shifts or vehicle lines.
Stellantis is working on technical solutions to manage the chip shortage, such as changing the dashboard of the Peugeot 308.
Palmer said the impact could continue into 2022. "We don't have great visibility," he said. "As such it would be imprudent to assume the issue is going to go away."
Overall, shipments were up 11 percent to 1,567,000, due to higher demand and product mix. Production losses due to the semiconductor chip shortage overshadowed the improvements over the first quarter of 2020, when production was suspended temporarily due to the pandemic.
Stellantis's revenues in its two main markets, North America and Europe, were balanced. North America contributed 15.9 billion euros ($19.4 billion) and Europe just over 16 billion euros ($19.6 billion). Both were improvements over 2020. South America revenues also were up, hitting 2.1 billion euros ($2.6 billion).
Many auto plants shut down in past few months
Many other auto plants, including those owned by General Motors and Ford, have shut down in the past few months because of the chip shortage. The shortage is primarily caused by semiconductor makers switching their factories to more profitable consumer electronics processors when automakers closed last year due to the coronavirus (COVID-19) pandemic.
The semiconductor shortage increased the average lead time for chip deliveries to 17 weeks in April, up from 16 weeks in March. The average lead time was around 12 weeks just before the beginning of the pandemic last year.
"All major product categories are up considerably," Susquehanna analyst Chris Rolland wrote in a recent investment note. "These were some of the largest increases since we started tracking the data."
Susquehanna, a global trading and technology firm, referred to the situation as a "danger zone" for chips as the risk of buyers engaging in behavior that magnifies the impact of the crisis increases.
Auto manufacturers are expecting to lose out on $110 billion in potential sales this year, due to a shortage of parts. These types of shortfalls encourage hoarding. A company that can't ship a $50,000 final product due to a shortage of $5 parts has every reason to hoard and stockpile said parts, whether they actually need them or not.
According to Rolland, the risk of a market overheat is rising due to the "bad behavior" encouraged by shortages. He noted that the semiconductor industry might be shipping more hardware than the actual level of customer demand can support.
Taiwan drought threatens to worsen semiconductor shortage
A severe drought hitting Taiwan threatens to worsen the semiconductor shortage. The country is home to two-thirds of the world's semiconductor manufacturing capacity, and semiconductor producers require voluminous quantities of water to churn out chips.
The drought's impact is so far modest as the government creates exceptions for semiconductor manufacturers. Taiwan's three science industrial parks, which house most of the island's chip-making facilities, have had to curb their water intake but are so far exempt from stoppages.
"Taiwan is the center of gravity for semiconductor manufacturing," said Syed Alam, global lead of the semiconductors practice at Accenture. "This is one thing you don't need adding more pressure on the situation."
Seasonal typhoons provide Taiwan with much of its water reserves. But a lack of storms last year has strained supplies, prompting the government to start rationing water for more than a million businesses and residents.
The global chip supply has been battered by a series of natural disasters recently.
Severe weather in Texas earlier this year forced Samsung Electronics Co. to close two of its chip factories in Austin temporarily. The auto chipmaker Renesas Electronics Corp.'s plant in Japan was hit first by an earthquake in February and then a fire in March that executives said would require months for recovery. (Related: Fire at Japanese chipmaker adds to collapsing microchip supply lines for automakers.)
Follow Glitch.news for more news and information related to the global semiconductor shortage.
TruePundit.com
News.Yahoo.com
ExtremeTech.com
Ramon Tomey


forms is a requirement no matter what your core business is.
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They say that if a job's worth doing, it's worth doing well.
And The Draft House is leading the craft beer revolution in Milton Keynes with an incredible range of almost 100 brews at its popular bar at The Hub.
Celebrate:MK went along to meet the team and was astonished to discover that they print off a fresh beer list every day to give to guests on a clipboard because the beers are changed on the taps and in the fridges every 24 hours.
The MK bar is The Draft House's first outside of London and has already made a huge impression on locals since replacing The Secklow Hundred in October.
General manager Richard Pedley explained: "Back when I first started drinking beer there was a very limited choice, but now there are so many different types to explore.
"Recently we had a coconut beer that was amazing and people loved it, and we've had a fantastic grapefruit beer too.
"It's great that people are exploring as beer doesn't have to be a basic thing, it can be intriguing and exciting.
"The trend seems to be that people aren't going out to get smashed any more, they are going out to try different beers and to enjoy the experience.
"And once people take their first step off the mainstream branded path they realise that they don't just like Guinness, for example, they like lots of other beers of that style and their taste evolves.
Local breweries Concrete Cow and Hornes have collaborated to create MK Pale No. 1 Citra beer specifically for The Draft House MK, so pop along to try a proper MK pint!
An exciting feature of The Draft House MK is that it serves beer paddles that hold three different thirds of a pint, so you can quickly explore all the pale ales, IPAs, weisse beers, Belgium ales, porters, sours and more. The beer paddles are available for just £5 from Sunday to Wednesday.
The food is great too after a new head chef was recently appointed, so use our voucher (below) to receive 20% off!


A program designed to help young boys and girls grow through fun and challenging activities designed to promote education, character and physical development.
An outdoor program created to develop character, academic skills, self-confidence, ethics, leadership and citizenship skills, and supports fitness in young men.
A program for young men and women designed to help young adults grow into responsible and caring adults through education and recreational experiences.
A co-ed mix of worksite and classroom-based programs that offer career education through role models and hands-on learning.
Delivering the programs of the Boy Scouts of America to the youth of southern Nevada and western Arizona. We work in partnership with local chartering organizations, community partners, parents and more than 7,381 volunteers to help serve the nearly 19,709 youth registered to Scouting programs.
What is the Scout Motto?


In developing goals, your team should also give attention to the specific plans your team will take to accomplish the goals. Otherwise the goals are meaningless.
You would determine such steps, for example, by learning from the experience of your mission agency and interviewing expatriates in Doha who have set up successful businesses. Note that these plans need not be completed in a linear way, i.e., you can overlap their accomplishment. If these were your plans, you could be seeking for a "person of peace", for example, as soon as you land. You need not wait until you've mastered Arabic to begin looking for a person of peace.
More specific planning is covered under the next question.


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R&B/Pop Superstar Ian Guerin Releases Celebratory New Single "For The Holidays"
November 14, 2019	MUSIC NEWS
Indie R&B/Pop singer/songwriter/producer Ian Guerin has recently released his first Holiday single entitled "For The Holidays" which is the bonus track on his highly successful sophomore album "Irreplaceable."
Released by Streetwalker Entertainment, "Irreplaceable" spotlights influences from a vast range of genres including R&B, Soul, Gospel, Pop and Funk, also featuring songs that are reminiscent of music from the amazing musical decades of the past.
Writing and performing since age 9, Guerin is now a mature musical force to be reckoned in the world of entertainment, and his new album "Irreplaceable" has already spawned several hits including the four time award-winning UK Best R&B Soul Song of the year Cry, UK #1 single Roll The Dice, and four time award-winning UK #1 single Free Time that has just been released in the United States.
Musically, "For The Holidays" contains elements of holiday & gospel music, R&B, and Pop/Rock music, while it lyrically explores a proposal to quote "Be An Item" with a significant other just during the Holiday period in lieu of spending the season alone.
"Most people want to have someone to be with during this time of the year, and finding someone to hang with just during Christmas is something I myself have been thinking of doing for years, so I figured I'd lay the idea down in a song and that's how "For The Holidays" came about," says Ian Guerin.
Check out "For The Holiday" everywhere here:
https://songwhip.com/song/ian-guerin/for-the-holidays
Watch the "For The Holidays" Lyric Video by Ian Guerin here:
Follow Ian Guerin on the web:
Ian Guerin Album "Irreplaceable" Streaming https://songwhip.com/album/ian-guerin/irreplaceable
TWITTER: @IAmIanGuerin
INSTAGRAM: https://instagram.com/IAmIanGuerin
FACEBOOK: https://www.facebook.com/IAmIanGuerin
REVERBNATION: https://www.reverbnation.com/ianguerin
CONTACT: worldstarpublicrelations@gmail.com
Previous Exclusive Interview with Gareth Johnson
Next Scott DeCarlo releases new Single/Video
Ronnue rises to Seattle's #1 independent artist of 2019
Motley Crue announce 2020 US Stadium tour with a few heavy hitters
2019 – A YEAR IN REVIEW

redpajama_set_name: RedPajamaCommonCrawl


There is still space in the 2015 ALMA Summer School! Join us in Penticton, BC for a week of learning and practicing all things ALMA. Previous experience with interferometers or ALMA is not necessary. We will cover the basics of radio astronomy, interferometry and the how-tos of ALMA (its capabilities, applying for time, managing projects and data reduction). This is a workshop style school with lots of time for hands-on applications. We have room for a maximum of 30 participants.
Please head to this site for more details about the summer school.
The call for ALMA Cycle 3 proposals ended 23 April with 1582 proposals, a record for any astronomical facility, requesting over 9000 hours of 12-m Array time (an oversubscription rate of ~4.3). Twenty-three proposals were submitted with PIs from Canadian institutions, down slightly from Cycle 2. PIs will be notified of the success of their proposals by July 29. Cycle 3 will begin on October 1.
If you are an ALMA user who would like one-on-one help with your data, the NAASC is here to help! You can arrange a trip to Victoria (or Charlottesville, VA) to get help from an ALMA expert in dealing with your dataset. Please contact Brenda Matthews [email] at NRC if you are interested in arranging a visit to Victoria, or submit a ticket to the ALMA Helpdesk. Details about visiting the North American ALMA Regional Center in Charlottesville, VA, can be found at this site.
Following the successful paper study of a multi-pixel focal plane array for the ALMA total power antennas, funded in part by the North American ALMA partnership's ALMA Development Studies program, the Millimetre Technology Group at NRC Herzberg is now planning to design, build, and test a small 4-pixel array prototype for the Band 3 frequency range of 84 to 116 GHz. This mini-array project will be used to validate the cold stop design and the very compact 2SB, dual polarization, RF assembly which has been developed in Victoria. Many challenges lay ahead in areas including lenslet design, cold stop optimization, machinability of very compact assemblies, and feasibility of integration into a limited cryostat space.
The Band 3 receivers continue to operate reliably with very few failures. Only one cold cartridge is presently in the Victoria laboratory and it is being used as a test-bed for the cartridge gain stability upgrade project.
NRC Herzberg is currently involved in a second Development Program activity to upgrade the gain stability of the Band 3 receivers. Over the past few months we have been able to test magnetic defluxing heaters on a cartridge and have obtained promising results. In close collaboration with the North American partnership and the Joint ALMA Observatory, we are working towards a technical solution that improves gain stability at low cost and low risk for deployment in Chile.


Xitrix LED TV, LCD TV, Servers Feedback, Anyone?
Just came across this really enticing offer from a local Groupon clone seeling heavily-discounted Xitrix LED TVs for only PhP13,995.00 instead of the regular price of PhP24,000.00 "Xitrix 32-inch HD-Ready LED TV! Package includes a wall mount bracket and a 1-year warranty! Indulge to an audiovisual overload with this HD-Ready LED TV by Xitrix! Ignite your senses with the Xitrix 32-inch HD-Ready LED TV! This savvy LED 3D TV from Xitrix will definitely satisfy your yearnings for crisp and clear media entertainment. The Ultra-slim carries a brushed-finish 32-inch LED display with HD-ready 1360 x 720p resolution to lend a crisp, sharp and incomparable viewing experience. Push your media boundaries with the LED TV's HDMI and USB ports, NTSC tuner, USB HD Video Playback for more options to amplify your viewing and gaming enjoyment. Started out as a computer systems company that provides computing products and sevices, Xitrix has manage to play an integral part in competing with other major electronics brands, making the brand, Xitrix a trusted name in the said industry. Xitrix takes pride in being ISO certified and continues to demonstrate its commitment in designing top quality electronic products as well as computer peripherals that corresponds to every customer's electronics and digital need. Technical specifications Dimension: 77.2 x 48 x 4.9cm Resolution: Dynamic Contrast Ratio Pixel Pitch: 1360x720pHD Ready Display color: 16.7Million Display color" Quesstion: How reliable are Xitrix LED TVs? where is it manufactured? I supposed it's made in China. Local support or rather Xitrix service centers? There's the official website that points to a place in Cubao, Quezon City. most importatant question: are xitrix LED TVs worth it?
I love the Hyundai Tucson with its fluidic design now applied to the Hyundai Accent, Hyundai Elantra, Hyundai Eon, and Hyundai i10, Hyundai i30 and others the Hyundai Tucson I did not choose vs my Toyota Innova since I needed more passenger space then Now I'm keen on buying a hatchback, a Honda Jazz to be exact when I confirmed the news that the Hyundai Accent Hatchback is coming to the Philippines and it comes in diesel, not gas, variants with either manual or automatic transmission (MT/AT) Now, how does the hyundai accent fuel consumption compare to the hyundai tucson sedan gas variant? I wanted to know the kilometers/liter (miles per gallon) more like gas vs diesel.


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Jan Brewer and Prisons-for-Profit: How we pay.
The escapes last Friday were from an MTC-operated prison, but CCA hosted a riot recently, and has some murders in their prison to account for, among other things. So either the public is unsafe, or more vulnerable prisoners are in the care of the private prison industry. Why then, should any state farm out the care of their prisoners to them? How is public interest being served by the Governor and her legislative allies?
At least the ADC fought to keep maximum security and death row from being privatized - that alone should have given the rest of us a good clue that there's cause for concern, though, even as they argue that some populations can be handled by private industry. Clearly that doesn't include "medium" security risks, as they're killing each other and running away at an astounding rate.
What a shame to think that we spend more on incarceration already than we do on educating our kids. That money sure isn't going to prisoner health care, security, or improvement of the conditions of confinement, is it? The profits these companies make are no small change, and come at the expense of prisoners and the public alike, trickling down into political campaigns in exchange for promises of more criminalization and prisoners for them to feed on.
End Arizona's prison privatization now. Make no mistake: those greedy SOBs don't care a lick about helping our struggling communities - they care only about the money they can extract from the rest of us.
Governor Jan Brewer's CCA Ties Burn Like Neon, and News for Liberals: J.T. Ready's Still a Neo-Nazi
By Stephen Lemons
CCA RULES
In May, I reported in my Feathered Bastard blog that executives and lobbyists for the giant, Tennessee-based prison company Corrections Corporation of America had donated $1,780 in "seed money" for Governor Jan Brewer's Clean Elections campaign.
Such early contributions are limited to $140 per person. But if that seems like chump change, consider that CCA also contributed a whopping $10,000 to the campaign for Prop 100, the state sales-tax initiative, the success of which was considered key to Brewer's bid to be more than an "accidental" governor.
The proposition was approved overwhelmingly by voters in May.
What's the big deal with the CCA contributions? CCA operates six prisons in Arizona, three of which house detainees for U.S. Immigration and Customs Enforcement.
As this column goes to press, SB 1070, Arizona's "breathing-while-brown" law, awaits the decision of U.S. District Judge Susan R. Bolton on whether she will grant an injunction of all or part of the statute.
The various enforcement provisions of 1070 practically ensure that more undocumented folks will be turned over to ICE. CCA probably will end up holding some of these individuals as they wait for removal proceedings or if they are convicted of federal immigration-related crimes.
So CCA stands to profit from SB 1070, and as recent reports from the investigative magazine In These Times and Phoenix's CBS 5 (KPHO) indicate, Brewer's relationship to CCA runs far deeper than just the political contributions mentioned above.
In These Times' July issue featured a story by Beau Hodai that revealed that Brewer's top flack, Paul Senseman, worked for Arizona's Policy Development Group, which lists CCA as a client. Senseman's wife, Kathy, is listed with the firm as a lobbyist for CCA.
Hodai also reported that the CCA employs Highground Public Affairs Consultants to represent its interests in Arizona. Highground's president is Chuck Coughlin, Brewer's top political adviser and the man running her gubernatorial campaign.
Though In These Times was the first to publish this information, CBS 5's investigative unit was the first to run with it locally.
During a recent newscast, reporter Morgan Loew revealed that CCA gets $11 million a month for inmates in the company's Arizona facilities.
Loew got that figure from the U.S. Marshal's Office. Marshal David Gonzales confirmed the figure to me. But he said that's just what he pays CCA for holding his prisoners, many of whom have been convicted on immigration-related offenses.
So that $11 million doesn't include whatever ICE pays CCA for the same services. I've asked ICE for that number, but it hasn't gotten back to me.
Loew sandbagged Brewer at an event, but Brewer refused to answer questions about her advisers' ties to CCA.
Brewer's boy was willing to chat it up with me about his big-dollar, private prison client, however.
Clearly miffed by the CBS 5 report, Coughlin referred to it as "drive-by" journalism, and claimed that CCA "doesn't house any Arizona prisoners."
"They don't house those types of inmates," insisted Coughlin regarding CCA and immigration-related collars. "[The CBS 5 report] is . . . a total piece of made-up journalism."
When I told him that I'd been to the federal courthouse in Tucson myself, and witnessed CCA buses carting people convicted of immigration crimes, he backpedaled — but not by much.
"That may be a federal contract," he said. "It has nothing to do with the state."
But it will have something to do with the state if 1070 takes effect, as 1070 is all about local police enforcing federal immigration law to the fullest extent possible. Indeed, law enforcement agencies that do not enforce 1070 can be sued by Arizona citizens under one of the law's provisions.
The law makes "attrition through enforcement" the policy of Arizona, and one provision requires that all those arrested have their immigration status checked before they are released.
If CCA ends up holding some of these individuals, then 1070 will benefit CCA directly.
"If that happens, if it were the case, if ICE does," scoffed Coughlin. "You have a lot of ifs down the road that's not a matter of fact right now. We're not working on speculative ventures here. We had no position on 1070. We did not lobby on 1070."
Didn't lobby on 1070? That's one hard-to-swallow lump of coal. I asked Coughlin if he was telling me he'd never talked to Brewer about 1070 or advised her to sign the bill, as many presume he did.
"I talk with her about a lot of stuff," he admitted. "Of course, we talked about 1070. We run her campaign. Absolutely."
Coughlin also admitted that his firm began representing CCA "over a year ago." So he was representing CCA at the same time he was advising Brewer on whether to sign the law.
If that's not a conflict of interest big enough to drive a semi through, I don't know what is.
Neither Brewer's flack Senseman nor CCA responded to requests for comment for this column. But when I wrote about CCA and Brewer in May, CCA spokeswoman Louise Grant was not shy about gabbing.
Grant maintained that CCA has no position on 1070. She denied that the law would be good for her employer or that CCA had any influence over the drafting of the law.
"CCA has had no involvement whatsoever with this legislation," she told me at the time. "And we will not have any involvement with it."
Well, not until local cops start handing over people to ICE. After that, despite Grant's disavowals, CCA will be involved.
Don't get me wrong. I'm not positing a conspiracy theory. In my view, the odious ideology of nativism was the driving force behind the passage of SB 1070.
But Coughlin clearly is making bank off CCA. And the company knows where its croissant is buttered.
Everybody can smell the links between Brewer and CCA. They stink like one of Brewer's headless bodies in the desert. Or they would, if those bodies were real.
Posted by Prison Abolitionist at 11:17 AM
Labels: campaign financing, corruption, governor brewer, private prison lobby
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A calm person tends to be more careful about their lifestyle, more respectful towards their body and conscious about what they eat. The stresses of social pressure lead us to take food that is harmful to teeth; they were not made to process so much sugar, salt or fat. Dentists were invented to overcome this issue, which arises through unnatural behaviour. This hints at the capacity we all have to find a way to work out solutions to the problems we encounter whenever we wander too far off the path of what is natural for the body. At one level, the cycle of all life is one of destruction and repair.
On a very simple level, we can see how it is thoroughly necessary to keep good care of our teeth. Dentistry is a real and important practicality, and demonstrates a relationship between the individual – who has the need for expert help – and society, which provides it. The high reward for taking care of our teeth is having good teeth – the same principle applies to everything else in our lives.
This is as true for the other dimensions of life as it is for the physical. We need to approach all things with a continuous, conscientious attention to the needs of self-renewal, whether spiritual or phenomenal, social or individual.
In important ways our relationship with our community is symbolical. It corresponds to the wisdom we have gained about the practicalities of living a spiritual life within the constraints not only of physicality but also of our associations.
The highest measure of a person is how well they demonstrate their spiritual attainment in everyday interactions and undertakings. Involvement in life, through projects and connections, will always test the authenticity and validity of our characteristic choices.
Entrusted with the divine spark, we have a sacred stewardship to fulfil the potential of such a privilege. Our mission in life is to dramatise our defining qualities and most subtle realisations in a practical form, so we are required to make known to the world our most inspired sacred vision.
Dental work is an artificial compensation – a remedy for previous imperfections – and it is surely better to do the right thing early than to repair the damage later since prevention is better than cure. Yet some people are shallow, lazy, immature or simply content to accept the false and easy; either they cannot see how short-sighted is this strategy or cannot find the necessary power of will.
However blessed we may feel to have achieved a measure of freedom through spiritual attainment, without involvement in ordinary life such achievements lack the necessary depth of meaning to bring true happiness. Yet, when our creative ingenuity is completely explored and brought to the service of others – as dentists, clerks or poets – then inevitably we find ourselves favoured with good fortune and joy.


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New Hillsider's Supporter - 11 January 2021
Malvern Town like nothing more than welcoming new supporters from the local community along to the HDANYWHERE Community Stadium.
The 'Hillsiders' media manager Andy Poole communicates. "That was the case for our Worcestershire Senior Cup tie against Worcester Raiders in December when local autistic football fan, David Martin, came along to show his support and after a thoroughly enjoyable evening, his parents Gary and Michelle, say that he is keen to return on future occasions."
"I really enjoyed my first trip to Malvern Town FC," said David. "Grassroots football is so entertaining and I am glad that the team ran out winners in the end. It was really nice of the club to let me meet captain, Louis Loader, at the end of the game; he was really friendly and we spoke about the match. I would definitely like to come back again regularly as soon as football returns."
Community Development Officer, Bryan Craven, added: "Malvern Town fans have been so welcoming to people of all backgrounds who have come along to support the club. I'd like to encourage anyone who during these days of lockdown is thinking about coming to the HDANYWHERE Community Stadium to get their football fix once restrictions are lifted, to do so. We have a growing community of people here who are ready to welcome all new faces who want to come along and be part of what we are building here, a local force for positivity!"
We are told that one of David's hobbies is collecting and swapping Premier League football stickers, so if anyone has any that they would like to give or swap, please contact us via the club. We firmly believe that football belongs to and should be enjoyed by anyone who wants to participate in it, be it as players, match officials, volunteers or spectators.
In all of our activities we will not discriminate or in any way treat anyone less favourably on grounds of age, gender, gender reassignment, sexual orientation, marital status, race, nationality, ethnic origin, colour, religion or belief, ability or disability. We will ensure that we treat people fairly and with respect, whilst providing access and opportunities for all members of the community to take part in and enjoy our activities.
As a club we will not tolerate harassment, bullying, abuse or victimisation of an individual. This includes sexual or racially based harassment or other discrimatory behaviour, whether physical or verbal. The club will work to ensure that such behaviour is met with appropriate action in whatever context it occurs.
We have a commitment to taking positive action where inequalities exist and as we move into 2021, these are the values that we will continue to hold dear and work hard to achieve throughout the year ahead.
Club Index Previous


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Q: Upvoting the "possible duplicate" comment counts as flag as duplicate? If someone already flagged a question as duplicate and there is already the auto-generated "possible duplicate" comment visible, like for example:

possible duplicate of How to compare Strings in Java

Is upvoting this duplicate-comment considered as a flag-as-duplicate or should I also flag the question?
For the case the upvote of the dupl-comment is not considered as a flag-as-duplicate: Maybe it should? It would be more convenient than clicking through the flagging menus. Also I think an upvote of the dupl-comment is a pretty clear expression already that the user agrees that it is a duplicate.
see also the related question here: Auto-generate the "possible duplicate" comment when question is flagged as a duplicate

A: Since the comment was generated by a flag (or vote) to close, adding another flag of the same kind would be without a consequence anyway. Close votes have a cumulative effect, flags do not.
You can still upvote if you feel the duplicate is spot on; though this is not of much consequence either.

A: No, upvoting a comment is not flagging.
And it should not be. We don't want people not knowing that flag post implicitly by upvoting comments. Let's keep upvoting and flagging seperate to avoid a mess. We already have enough invalid flags in the queue.
If you don't have the time to make 3 click to flag a post then you should not do it at all since you might act too fast anyway.

redpajama_set_name: RedPajamaStackExchange


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Air Force One: A look at other Boeing deals involving Trump
By Matthew Kazin Published February 27, 2018 TransportationFOXBusiness
Boeing CEO: See defense as a growth area for the future
Boeing CEO Dennis Muilenburg on the company's digital solutions business, the government's potential boost to defense spending, the Iran nuclear deal and the company's investment in STEM programs.
The U.S. deal with Boeing that lowered the cost of Air Force One by more than $1.4 billion isn't the first one involving the manufacturer and President Donald Trump.
Over the course of the president's first year in office, Boeing has sometimes signed agreements at the White House with Trump looking on.
Most recently, Norway's Prime Minister Erna Solberg announced in January during a joint press conference with Trump at the White House that the country would purchase five P-8A Poseidon aircraft from Boeing. A derivative of Boeing's Next Generation 737-800, the aircraft is used for long-range anti-submarine and anti-surface warfare, as well as intelligence, surveillance and reconnaissance missions.
Singapore Airlines inked a deal worth $13.8 billion with Boeing last November for 20 of the company's 777-9 aircraft and 19 of its 787-10 Dreamliner jets. The airline had already placed an order for 30 of the Dreamliners, serving as the initial customer for the long-haul jet. The airline's CEO, Goh Choon Phong, signed the deal at the White House, joined by Kevin McCalister, the president and CEO of Boeing Commercial Airplanes, and Trump, who said the agreement would employ 70,000 people in the U.S.
More from FOX Business
Trump wins big discount from Boeing for new Air Force One planes
Diageo's 'Jane Walker' arrives after Doritos' proposed female brand faded
Lowe's looks to keep up with Home Depot as 4Q earnings loom
Boeing signed a memorandum of understanding in September with Malaysia Airlines for 16 airplanes at a ceremony at the St. Regis Hotel in Washington, D.C. During a meeting with Trump, Malaysia's Prime Minister Najib Abdul Razak said the country intended to have the flag-carrying airline purchase more Boeing aircraft in future to help strengthen the American economy.
"We have committed to 25 planes of the 737 MAX 10, plus eight 787 Dreamliners, and a very strong probability—not possibility—that we will add 24 to 25 more 737 MAX 10 in the near future," Razak said during the meeting. "So within five years, the deal will be worth beyond $10 billion."
Trump also owns a Boeing 757, which he used to travel to various stops during his presidential campaign.


It cannot be contagious if you avoided the oils. If the oils were not passed on to you, you will probably not get it. Plus, there is a minute chance that you are not contagious yet. The more you are exposed to it the better the chances of an outbreak.


Live Eindhoven '87 is a remastered reissue of American thrash metal band Testament's Live at Eindhoven EP, released on April 14, 2009 through Prosthetic Records. It now features the group's complete 1987 performance at that year's Dynamo Open Air Festival in Eindhoven, as well as a newly designed cover artwork.
This 2000s thrash metal album–related article is a stub. You can help Wikipedia by expanding it.
This page was last edited on 17 October 2018, at 03:25 (UTC).


text:
Q: Как транслировать изображение с экрана на фронтальную камеру? Мне нужно перенаправлять на канал камеры другое изображение для того чтобы приложение думало что смотрит фронтальной камерой на человека а это было фото или видео воспроизводящееся на экране.
Как сделать трансляцию экрана на фронтальную камеру?
Я искал подобные приложения на Google Play, но не нашел ничего подобного.


text:
Q: In vs studio python Print ("Welcome") it does not run when I type the file name I used a simple code for python in my VS Studio. Print ("Welcome")  when I run it through the run button it works fine but when I want to run it through typing  the file name ( eg .\02_hello.py) and press enter it doesn't run and instead leave a blank line. I don't know what's wrong.please help
I want the python code to run through typing the file name in terminal window of vs studio just as it works fine when I use the run button to run code.

A: You need to specific the python interpreter to run your code
try:
python ./02_hello.py

A: Because you aren't telling the terminal what that python file should do. In default it opens the file in vscode. Try this:
python 02_welcome.py

A: check if you have a file of that name on path.
also type :
python .\02_welcome.py


All movement depends on the spine, so keep it supple.
Yoga is a play between strength and flexibility. This yin and yang balance is especially important in the spine, as all body movements depend on its health. Here, we'll focus on yoga postures that encourage a supple spine.
The most obvious bestowers of spinal flexibility are backbends, and most of them simultaneously strengthen the back. They also flatten the curvature of the upper back. Forward bends, on the other hand, work by stretching the spine and flattening the curvature of the lower back. Both movements should be practiced in order to maintain the proper curvature of the spine.
The spine isn't limited to moving only forward and backward, though; adding twists and side bends to a practice creates overall spinal flexibility.
Here are five yoga poses to put into practice for a bendy back. Remember that a healthy spine requires a balance between strength and flexibility, so these postures should be practiced with their counterposes and woven into a well-rounded sequence.
Benefits: Also known as back stretching pose, this classical hatha version is a passive forward bend. It stretches the entire back body, increases circulation to the spinal muscles and nerves, and gives the heart a gentle massage.
Step-by-Step: Sit on the ground with the legs and feet together, feet relaxed. Inhale and reach the arms up. Exhale and bend forward from the hips. Reach the arms forward as you come down, making a conscious effort to stretch the back. Hold onto the outsides of the feet, ankles, or shins. Relax the neck so its curvature is in line with the rest of the spine; otherwise, you might stress the upper back, shoulders, and neck. Hold Forward Bend pose for several breaths. With each exhalation, move deeper into the bend. With each inhalation, relax a little more. Inhale to reverse out of the pose.
Benefits: In Extended Cobra pose, the hands are pushed into the floor to lift the upper body, increasing spinal flexibility. Low Cobra pose—in which the hands aren't pushed into the floor at all—tends to work more on spinal strength.
Step-by-Step: Lie on the stomach with feet hip-distance apart. Place the forehead on the floor and the hands next to the chest, fingers spread wide. Inhale and push into the hands to lift the head, chest, and belly. Keep a slight bend in the elbows so the shoulders can move away from the ears. Hold Extended Cobra for several breaths. Exhale to lower.
Benefits: Much like Plow pose, Bow pose stretches the entire spine—cervical, thoracic, lumbar, and sacral. It combines and enhances the effects of Cobra pose and Locust pose. The three should be practiced together for total spinal health.
Step-by-Step: Lie on the stomach with the knees hip-distance wide and forehead on the floor. Bend the knees and clasp the outsides of the ankles. Point the toes, inhale, and push the feet away. Keep the neck in line with the rest of the spine. Stay in this pose for several breaths. Exhale to release.
Benefits: In Half Spinal Twist, each vertebra is rotated to both the right and the left, increasing side-to-side mobility. This pose also increases the production of synovial fluid in the joints and rejuvenates all of the ligaments attached to the spine.
Step-by-Step: Sit on the heels in Thunderbolt pose. Drop the hips to the right, outside of the heels. Cross the left ankle outside of the right knee, and place the foot flat on the ground. Press the left hand into the ground behind the spine to lengthen upward. Inhale and reach the right hand up. Bend the elbow, using the arm as a lever against the knee. Exhale and twist to the left. Stay in the pose for several breaths. Inhale to untwist; then repeat on the other side.
Benefits: Triangle pose offers a lateral stretch to the spine and its surrounding muscles. We rarely stretch the spine to the side, outside of yoga, so it's an important movement to include in any yoga sequence. This version of Triangle is most appropriate for beginners.
Step-by-Step: Stand with the feet wide, several feet apart. Turn the right toes out 90 degrees. Raise the arms to shoulder height, palms facing down. Place the right hand on the right thigh. Exhale and bend to the right, sliding the right hand down the right leg. Reach the left arm up and look up toward the hand. Stay in the pose for several breaths. To come out of Triangle pose, engage the abdominal muscles, inhale, and rise. Repeat on the other side.


text:
> 🛑 **Notice**: This repository is no longer maintained; No further Issues or Pull Requests will be considered or approved.

# Winds - A Beautiful Open Source RSS & Podcast App Powered by GetStream.io

[![Slack Community](https://img.shields.io/badge/Slack%20Community-Get%20Invite-green.svg)](https://communityinviter.com/apps/winds-community-hq/winds-2-0)
[![Build Status](https://travis-ci.org/GetStream/Winds.svg?branch=master)](https://travis-ci.org/GetStream/Winds)
[![codecov](https://codecov.io/gh/GetStream/Winds/branch/master/graph/badge.svg)](https://codecov.io/gh/GetStream/Winds)
[![Open Source](https://img.shields.io/badge/Open%20Source-100%25-green.svg)](https://shields.io/)
[![Maintenance](https://img.shields.io/badge/Maintained%3F-Yes-green.svg)](https://github.com/GetStream/winds/graphs/commit-activity)
[![Built With](https://img.shields.io/badge/Built%20With-❤%20in%20Boulder,%20CO-green.svg)](httpds://shields.io/)
[![StackShare](https://img.shields.io/badge/Tech-Stack-0690fa.svg?style=flat)](https://stackshare.io/stream/winds)

## Description

Winds is a beautiful open-source RSS and Podcast app created using React & Redux on the frontend and Express.js on the backend. Use the free hosted version or run it on your own server and customize it as you see fit. Contributions in form of pull requests are always appreciated. Activity Feeds & Discovery in Winds are powered by [Stream](https://getstream.io/get_started/), the app leverages [Algolia](https://algolia.com?ref=stream) for search, [AWS](https://aws.amazon.com/) for hosting, [MongoDB Atlas](http://mbsy.co/mongodb/228644) for a hosted database (DBaaS), and [SendGrid](https://sendgrid.com/) for email. All of these services have a free tier.

## Getting Started

To get started with Winds, please download [the latest release](https://s3.amazonaws.com/winds-2.0-releases/latest.html)

## Featured RSS & Podcasts

Have a popular RSS or Podcast and want to be featured? Reach out to winds@getstream.io. We reply to every message.

# Features at a Glance
Winds is packed full of awesome features behind a beautiful user interface and user experience. Here's a quick look at what the project has to offer:

## Beautiful UI
![Winds UI](https://i.imgur.com/W1fpowV.png)

## RSS & Podcast Recommendations
![Winds RSS & Podcast Recommendations](https://i.imgur.com/AlVgDTg.png)

## Integrated Search
![Winds Search](https://i.imgur.com/zaWtNfV.png)

## Podcast Player
![Winds Podcast Player](https://i.imgur.com/th247rA.png)

## RSS Reader
![Winds RSS Reader](https://i.imgur.com/D3wt7W3.png)

## TOCd

*   [Roadmap](#roadmap)
*   [Powered By](#powered-by)
    *   [Stream](#stream)
    *   [Algolia](#algolia)
    *   [MongoDB](#mongodb)
    *   [SendGrid](https://sendgrid.com)
    *   [AWS](https://aws.amazon.com/)
*   [Tutorials](#tutorials)
*   [Download](#download)
*   [Contributing to Winds](#contributing-to-winds)
*   [Support](#support)
*   [Maintenance & Contributions](#maintenance-and-contributions)

## Roadmap

Help us improve Winds and/or vote on the [Roadmap for 2.1](https://github.com/GetStream/Winds/issues/191)

*   [ ] Search detail screen
*   [ ] Playlist support (partially implemented)
*   [ ] Team support (share an activity feed with colleagues or friends to discover and collaborate)
*   [ ] Mobile application powered by React Native

## Powered By

1.  [Express](https://expressjs.com?ref=winds)
2.  [React](https://reactjs.org?ref=winds) & [Redux](https://redux.js.org?ref=winds)
3.  [Algolia](https://www.algolia.com?ref=winds)
4.  [MongoDB Atlas](http://mbsy.co/mongodb/228644)
5.  [SendGrid](https://sendgrid.com?ref=winds)
6.  [Bull](https://github.com/OptimalBits/bull?ref=winds)
7.  [Mercury](https://mercury.postlight.com?ref=winds)
8.  [Stream](https://getstream.io?ref=winds)
9.  [Sentry](https://sentry.io/?ref=winds)
10. [AWS](https://aws.amazon.com/?ref=winds)

**The full stack can be found on [StackShare.io](https://stackshare.io/stream/winds).**

### Stream

[Stream](https://getstream.io/?ref=winds) is an API for building activity feeds. For Winds the follow suggestions and the list of articles from the feeds you follow is powered by Stream. Stream accounts are free for up to 3 million feed updates and handle personalization (machine learning) for up to 100 users.

### Algolia

[Algolia](https://algolia.com?ref=winds) is used for lightning fast and relevant search. We use their [JavaScript search client](https://www.npmjs.com/package/algoliasearch?ref=winds) to easily setup the Winds search implementation. Algolia, accounts are free up to 10k records and 100k operations.

### MongoDB

[MongoDB Atlas](http://mbsy.co/mongodb/228644) provides a Database as a Service, and serves as the backend datastore for Winds.

## Tutorials & Blog Posts

The following tutorials will not only help you start contributing to Winds, but also provide inspiration for your next app.

**Note:** We're actively working on this portion of the README. To stay up to date with the latest information, please signup for the hosted version at [https://getstream.io/winds](https://getstream.io/winds).

1.  [Implementing search with Algolia](https://hackernoon.com/integrating-algolia-search-in-winds-a-beautiful-rss-podcast-application-f231e49cdab5)
2.  [Stream and Winds](https://getstream.io/blog/the-engine-that-powers-winds/)
3.  [Running PM2 & Node.js in Production Environments](https://hackernoon.com/running-pm2-node-js-in-production-environments-13e703fc108a)
4.  [Creating a RESTful API design with Express.js](https://hackernoon.com/building-a-node-js-powered-api-with-express-mongoose-mongodb-19b14fd4b51e)
5. [Takeaways on Building a React Based App with Electron](https://medium.com/@nparsons08/publishing-a-react-based-app-with-electron-and-nodejs-f5ec44169366)
6. [The Winds Stack](https://stackshare.io/stream/how-stream-built-a-modern-rss-reader-with-javascript)
7. [Building Touch Bar Support for macOS in Electron with React](https://hackernoon.com/winds-2-1-building-touch-bar-support-for-macos-in-electron-with-react-e10adb811c91)
8. [Testing Node.js in 2018](https://hackernoon.com/testing-node-js-in-2018-10a04dd77391)
9. [Simple Steps to Optimize Your App Performance with MongoDB, Redis, and Node.js](https://hackernoon.com/simple-steps-to-optimize-your-app-performance-5700d8b58f58)
10. [Getting Started with Winds & Open Source](https://hackernoon.com/winds-an-in-depth-tutorial-on-making-your-first-contribution-to-open-source-software-ebf259f21db2)
11. [Deploying the Winds App to Amazon S3 and CloudFront](https://getstream.io/blog/deploying-the-winds-app-to-amazon-s3-and-cloudfront/)
12. [Deploying the Winds API to AWS ECS with Docker Compose](https://getstream.io/blog/deploying-the-winds-api-to-aws-ecs-with-docker-compose/)

## Download

To download Winds, visit [https://getstream.io/winds/](https://getstream.io/winds/).

## Contributing to Winds

### TL;DR

Commands:

*   `brew install redis mongodb`
*   `brew services start mongodb`
*   `brew services start redis`
*   `cd Winds`
*   `cd api && yarn`
*   `cd ../app && yarn`

Sign up for both Stream and Algolia, and create the following `.env` file in the `app` directory, replacing the keys where indicated:

```
DATABASE_URI=mongodb://localhost/WINDS_DEV
CACHE_URI=redis://localhost:6379
JWT_SECRET=YOUR_JWT_SECRET

API_PORT=8080
REACT_APP_API_ENDPOINT=http://localhost:8080
STREAM_API_BASE_URL=https://windspersonalization.getstream.io/personalization/v1.0

STREAM_APP_ID=YOUR_STREAM_APP_ID
REACT_APP_STREAM_APP_ID=YOUR_STREAM_APP_ID
REACT_APP_STREAM_API_KEY=YOUR_STREAM_API_KEY
REACT_APP_STREAM_ANALYTICS=YOUR_STREAM_ANALYTICS_TOKEN
STREAM_API_KEY=YOUR_STREAM_API_KEY
STREAM_API_SECRET=YOUR_STREAM_API_SECRET

REACT_APP_ALGOLIA_APP_ID=YOUR_ALGOLIA_APP_ID
REACT_APP_ALGOLIA_SEARCH_KEY=YOUR_ALGOLIA_SEARCH_ONLY_API_KEY
ALGOLIA_WRITE_KEY=YOUR_ALGOLIA_ADMIN_API_KEY
```

> Note: If you are running the test suite, you will need to have a test version of the `.env` file inside of the `api/test` directory.

Then run:

*   `pm2 start process_dev.json`
*   `cd app && yarn start`

### Clone the Repo

```bash
git clone git@github.com:GetStream/Winds.git
```

### Install dependencies

The following instructions are geared towards Mac users who can use `brew` ([Homebrew](https://brew.sh/)) to install most dependencies. Ubuntu users can use `apt`, and Windows users will have to install directly from the dependency's site. Non-debian-based Linux users will probably be able to figure it out on their own :)

*   `cd Winds/app`
*   `yarn`
*   `cd ../api`
*   `yarn`

### Start MongoDB Locally

Winds uses MongoDB as the main datastore - it contains all users, rss feeds, podcasts, episodes, articles, and shares.

If you're on a Mac, you can install MongoDB through [Homebrew](https://brew.sh/) by running:

```
brew install mongodb
```

_(You can also install MongoDB from the [official MongoDB site](https://www.mongodb.com/download-center).)_

You can also run MongoDB in the background by running:

```
brew services start mongodb
```

### Start Redis Locally

At Stream, we use Redis as an in-memory storage for the Winds podcast processing and RSS processing workers. It contains a list of podcasts and RSS feeds, which the workers pick up and process using the `bull` messaging system.

If you're on a Mac, you can install Redis through [Homebrew](https://brew.sh/) by running:

```
brew install redis
```

_(You can also install Redis from the [official Redis site](https://redis.io/download).)_

Then, start Redis by running:

```
redis-server
```

...which creates (by default) a `dump.rdb` file in your current directory and stores a cached version of the database in that location.

You can also run Redis in the background by running:

```
brew services start redis
```

### Loading Test Data

For testing purposes, you will want to use the test data located [here](https://s3.amazonaws.com/winds-hosted/static/export/WINDS.zip).

Use [`mongoimport`](https://docs.mongodb.com/manual/reference/program/mongoimport/) or [`mongorestore`](https://docs.mongodb.com/manual/reference/program/mongorestore/) to import the data. There are two username and password combinations for testing:

**Username**: `admin@admin.com`

**Password**: `admin`

**Username**: `test@test.com`

**Password**: `test`

You will need to run the `FLUSHALL` command in Redis to ensure that the new content is picked up.

> Note: This will override any local data that you may have. Please be cautious! Also, this will not create Stream follows – please follow feeds manually to generate them.

### Stream

#### Sign up and Create a Stream App

To contribute to Winds, sign up for [Stream](https://getstream.io/get_started?ref=winds) to utilize the activity and timeline feeds.

_(Reminder: Stream is free for applications with less than 3,000,000 updates per month.)_

*   [Sign up for Stream here](https://getstream.io/get_started?ref=winds)
*   Create a new Stream app
*   Find the App ID, API Key, and API Secret for your new Stream app

#### Add your Stream App ID, API Key, and API Secret to your `.env`

Append the Stream App ID, API Key, and API secret to your `.env` file:

```
STREAM_APP_ID=YOUR_STREAM_APP_ID
STREAM_API_KEY=YOUR_STREAM_API_KEY
STREAM_API_SECRET=YOUR_STREAM_API_SECRET
```

#### Create Your Stream Feed Groups

Once you've signed in, create "feed groups" for your Stream app.

A "feed group" defines a certain type of feed within your application. Use the "Add Feed Group" button to create the following feeds:

| Feed Group Name | Feed Group Type |
| --------------- | --------------- |
| `podcast`       | flat            |
| `rss`           | flat            |
| `user`          | flat            |
| `timeline`      | flat            |
| `folder`        | flat            |
| `user_episode`  | flat            |
| `user_article`  | flat            |

It's fine to enable "Realtime Notifications" for each of these feed groups, though we won't be using those yet.

### Algolia

#### Sign up for Algolia and Create an Algolia App and Index

In addition to Stream, you also need to sign up for [Algolia](https://www.algolia.com/users/sign_up?ref=winds), to contribute to Winds, for the search functionality.

_(Algolia is free for applications with up to 10k records.)_

*   [Sign up for Algolia here](https://www.algolia.com/users/sign_up?ref=winds)
*   From the [Applications page](https://www.algolia.com/manage/applications), click "New Application" and create a new Algolia application. (We recommend something similar to `my-winds-app`)
    *   (Select the datacenter that's closest to you.)
*   From the application page, select "Indices" and click "Add New Index". (We recommend something similar to `winds-main-index`)

#### Add Your Algolia Application Id, Search-Only Api Key and Admin Api Key to Your `.env` File

From your app, click the "API Keys" button on the left to find your app ID and API keys.

Append your Algolia application ID, search-only API Key and Admin API Key to your `.env` file to look like this:

```
REACT_APP_ALGOLIA_APP_ID=YOUR_ALGOLIA_APP_ID
REACT_APP_ALGOLIA_SEARCH_KEY=YOUR_ALGOLIA_SEARCH_ONLY_API_KEY
ALGOLIA_WRITE_KEY=YOUR_ALGOLIA_ADMIN_API_KEY
```

### Start Backend Services

From the root directory, run:

```
pm2 start process_dev.json
```

To see logging information for all processes, run:

```
pm2 logs
```

### Start Frontend Electron / Web App Server

```
cd app && yarn start
```

### Running tests

Winds API server uses:

* [Mocha](https://mochajs.org) as testing framework
* [Chai](https://chaijs.org) as assertion library
* [Sinon](https://sinonjs.org) as mocking library
* [nock](https://github.com/node-nock/nock) as HTTP mocking library
* [mock-require](https://github.com/boblauer/mock-require) as module mocking library

Tests are located in [`api/test` folder](https://github.com/GetStream/Winds/tree/master/api/test).

File structure is intentionally mirroring files in `api/src` to simplify matching tests to tested code.

To run tests:

```
cd api && yarn run test
```

To run tests with extended stack traces (useful when debugging async issues):

```
cd api && yarn run test_deep
```

#### Adding new tests

Add your code to a file in `api/test` folder (preferably mirroring existing file from `api/src` folder).

Refer to [Mocha documentation](https://mochajs.org/#getting-started) for examples of using BDD-like DSL for writing tests.

Modules are mocked in [`api/test-entry.js`](https://github.com/GetStream/Winds/blob/master/api/test-entry.js#L21L27) as mocks have to be installed before any modules are loaded.

Fixtures are loaded via [`loadFixture`](https://github.com/GetStream/Winds/blob/master/api/test/utils.js#L59L101) function from [`api/test/fixtures` folder](https://github.com/GetStream/Winds/tree/master/api/test/fixtures)

Various utility functions are provided in [`api/test/util.js`](https://github.com/GetStream/Winds/blob/master/api/test/utils.js) (See other tests for examples of usage).

### Building a Production Version

Build a production version of Winds by running from root directory:

```
./api/build.sh
```

This creates production-ready JS files in api/dist.

To run the production JS files:

```
pm2 start process_prod.json
```

OR

**Prepare the build for Docker**:

`cd api && cd scripts && ./make-build.sh`

**Build the Docker container (API & all workers)**:

`cd ../ && docker-compose up`

The commands above will prepare and start the API (and all workers). The frontend will still need to be started manually.

## Debugging RSS & Podcast Issues

Unfortunately there is no unified standard for RSS.
Go to the `api` directory and run `yarn link` to make these commands available:

```
winds rss https://techcrunch.com/feed/
```

**Podcasts**:

```
winds podcast https://www.npr.org/rss/podcast.php\?id\=510289
```

**Open Graph scraping**:

```
winds og http://www.planetary.org/multimedia/planetary-radio/show/2018/0509-amy-mainzer-neowise.html
```

**RSS Discovery**:

```
winds discover mashable.com
```

**Article parsing (w/ Mercury)**:

```
winds article https://alexiskold.net/2018/04/12/meet-12-startups-from-techstars-nyc-winter-2018-program/
```

Pull requests for improved RSS compatibility are much appreciated.
Most of the parsing codebase is located in `api/src/parsers/`.

## Support

All support is handled via [GitHub Issues](https://github.com/getstream/winds/issues). If you're unfamiliar with creating an Issue on GitHub, please follow [these instructions](https://help.github.com/articles/creating-an-issue/).

## Maintenance and Contributions

Thank you to all of the maintainers and contributors who've helped Winds become what it is today and help it stay up and running every day. We couldn't do it without you!

### Special Shoutouts To:

*   [Hackernoon](https://hackernoon.com/)
*   [Product Hunt](https://www.producthunt.com/)
*   [StackShare](https://stackshare.io/stream/how-stream-built-a-modern-rss-reader-with-javascript)

### Primary Maintainers

*   [Nick Parsons](https://github.com/nparsons08)
*   [Amin Mahboubi](https://github.com/mahboubii)
*   [Thierry Schellenbach](https://github.com/tschellenbach)
*   [Josh Tilton](https://github.com/tilton)

### Contributors

*   [Tommaso Barbugli](https://github.com/tbarbugli)
*   [Ken Hoff](https://github.com/kenhoff)
*   [Dwight Gunning](https://github.com/dwightgunning)
*   [Matt Gauger](https://github.com/mathias)
*   [Max Klyga](https://github.com/nekuromento)
*   [Zhomart Mukhamejanov](https://github.com/Zhomart)
*   [Julian Xhokaxhiu](https://github.com/julianxhokaxhiu)
*   [Jonathon Belotti](https://github.com/thundergolfer)
*   [The Gitter Badger](https://github.com/gitter-badger)
*   [Meriadec Pillet](https://github.com/meriadec)
*   [Alex Sinnott](https://github.com/sifex)
*   [Lawal Sauban](https://github.com/sauban)

## Revive RSS

RSS is an amazing open standard. It is probably the most pleasant way to stay up to date with the sites and podcasts you care about. Our reasons for contributing to Winds are explained in the blogpost [Winds 2.0 It's time to Revive RSS](https://getstream.io/blog/winds-2-0-its-time-to-revive-rss/). In this section we will list other open source and commercial projects that are having an impact on Reviving RSS:

* [Miniflux](https://github.com/miniflux/miniflux)
* [TwitRSSMe](https://twitrss.me/)
* [Feedly](https://feedly.com/)
* [NewsBlur](https://newsblur.com/)
* [Feedity](https://feedity.com/)
* [SaveRSS](https://mg.guelker.eu/saverss/)

## We are hiring!

We've recently closed a [$38 million Series B funding round](https://techcrunch.com/2021/03/04/stream-raises-38m-as-its-chat-and-activity-feed-apis-power-communications-for-1b-users/) and we keep actively growing.
Our APIs are used by more than a billion end-users, and you'll have a chance to make a huge impact on the product within a team of the strongest engineers all over the world.

Check out our current openings and apply via [Stream's website](https://getstream.io/team/#jobs).

redpajama_set_name: RedPajamaGithub


These family-friendly prices will give you more reason to travel Outback for the school holidays!
Passengers can save up to $50 per person on 1-day Mutawintji tours, while children joining the Historic Site tour travel absolutely free.
Mutawintji (pronounced moot-a-wint-ji) National Park, was once a busy meeting place for Australia's ancient indigenous inhabitants. Their dreamtime stories, history and teachings are taught through depictions such as stencils and engravings. Such artworks are abundant here, providing a unique insight into the life & culture of the Australian aboriginal people. Mutawintji holds evidence of Aboriginal occupation dating back over 8,000 years.
This tour includes access into the restricted access Historic Sites, which have been closed to the general public. To preserve the history of this significant area, all of our guides have received training and accreditation by the traditional land owners. As well as indigenous culture, there are abundant opportunities to spot local bird and wildlife in their natural habitats.
All tag-along children (0-13 years) joining our 2.5 hour Historic Sites tour are free!
Tag-alongs ex Broken Hill – travel in your own vehicle in a group with full commentary provided by UHF radio. Lunch and morning tea provided. Tag-alongs ex Mutawintji National Park (Historic Site tour) – meet us at Mutawintji National Park to join a 2.5 hour Historic Sites tour. No meals provided. Tag-along positions only available on confirmed departure dates due to minimum number requirements.


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title: Offline
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# Sorry!

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HOT FOR TEACHER performed for the El Dorado Hills Community last Friday, the 11th to well over 3,500 Van Halen fans of ALL ages! The wild crowd was singin' and dancin' to the sounds of summers past as the fellas ripped through a blazing 2 plus hour set that including everybody's favorite A and B side VH cuts.
Then, this past Saturday the boys bumped it up a notch and went into overdrive for a show complete with go-go dancers at the Grand Sierra Casino and Resort in Reno for the Xtreme Outlaws Off-Road Competition.
Next up, HFT is back at the Black Oak Casino in the Sonora Foothills on Friday the 25th.


One of my favorite shows is to see how some parents travel with kids by plane, train or bus and how they treat them. Not only should they need a procreation permit, a (non)accountability test to pass before choosing to have children (because the poor kids cannot be blamed for this), but they should be forced by law to provide the bare minimum level of education.
I am talking of course about the lack of education or common sense, and also about adapting to the environment. That's probably the reason why you are not allowed to take a crocodile as carry on pet during the flight and let it eat everything on sight – "what are U gonna do, it's a crocodile and it's hungry!".
The funny thing is that those children are not to be blamed for their behavior, they don't know any better.
Carry with you a "surprise element", something they appreciate a lot.
It's a proven fact that it's less complicated to travel alone then having 4 or 6 children levitating in the plane; or it's easier not to have very small children with you, but at least in theory you should know them well enough so you're able to press the right buttons for each of them.
You might wonder by now what has all this have to do with being employed. Well, there is a big connection, easily recognizable in everyday life. Especially when an employee does as he/she pleases, regardless of the other team members and the manager doesn't care to teach him/her better and doesn't provide any "entertainment" either.


Earlier in the campaign Rovers were somewhat steamrollered by the Latics when they went down 3-0 at the DW Stadium. After losing Ryan Sweeny to a red card on 30 minutes they immediately conceded a goal form the free-kick to Nick Powell. Then just after half-time Will Grigg showed just why he is on form when he netted the second for the home team. Ellis Harrison then conspired to see his spot kick saved with just 10 minutes left on the clock before Gavin Massey gave the score-line a very convincing look with his team's third.
On Saturday the Latics clinched automatic promotion with a 4-0 thrashing of nearby Fleetwood. The first half it was not the stroll in the park the scoreline reflects as Fleetwood put up a fight with boss John Sheridan left to rue what could have been had one of Ash Hunter's chances gone in.
Wigan got their opening goal in the 32nd minute as Max Power fired home and then saw Fleetwood crumble with Gavin Massey turning in the box before sliding the ball past Alex Cairns in the 36th minute to double the score.
In the second half, Dan Burn calmly fired home in the 57th minute, while fellow centre-half Chey Dunkley added the gloss as he converted from close range in the 66th minute.
Athletic Boss Paul Cook reflected after seeing his side secure promotion with three games to spare, "Blackburn got a little bit ahead of themselves when we had games in hand with some things said about us becoming fatigued, but we haven't. We're the first team to be promoted and we got to the quarterfinal of the FA Cup. I wish Blackburn and Shrewsbury, with a special mention to them, well."
"We're very grounded as a staff. It's a long journey in football and it is a great day. The record speaks for itself; clean sheets, goals, wins and the best teams in the league finish at the top. I'm so proud of the players. We might be a good fit now but football changes, my time at Portsmouth showed that when we were happy, and then it all changed."
"I'm going to enjoy tonight and it's great when you've managed or played for a club and you lead them to promotion, you'll always have a place in their heart."
It is over seventeen years since the teams last crossed paths in Bristol or Bath with Wigan enjoying the Premiership experience whilst Rovers struggled. Ironically in the 2000-01 season, the last time this fixture took place, both games finished 0-0. Overall home team seems to come out well. Rovers first ever meetings with Wigan were results to be savoured. On 16 October 1982 goals by Graham Withey (2), Paul Randall and Geraint Williams secured an impressive 4-0 victory. Larry Lloyd had an unhappy return to Eastville being one of two Latics players sent off, Alex Cribley being the other.
Rovers continued to dominate in these fixtures and have recorded 6-1 (1990) and 5-0 (1998) victories. The Latics only victory was a 3-2 win at Twerton Park on 5 September 1987. The last game between the clubs in Bristol was a 0-0 draw played on 16 September 2000.
Looking at the League table at the moment the Latics hold a three point advantage over Blackburn, with a better goal difference, going in to the final three games of the season.
They will be looking to achieve the league title they won in 2015/16 and can finish on 102 points should they win their remaining matches.
Speaking ahead of tonight's game Cook said, "We're now going into a three-game spell in which we can clinch the league title if everything goes our way and it's something myself and the players would really like to do for the supporters."
"I've said it all season, what you get is what you deserve and we've never changed our attitude from that. We have an opportunity now, with the away record being as strong as it is, to strengthen all of our statistics. Can we get to that magical 100 points which is an unbelievable target for any team?"
"It's always good to have a target, albeit we can speak more openly about it because we've been promoted and that sense of relief is there for everyone."
Talking about Rovers he said, "Bristol Rovers is always a tough place to go to and Darrell is a bright young manager who has had an outstanding time with his club so far. Darrell always puts an attacking team out because he's a very positive manager. He likes to have his two lads up front and Bristol Rovers always get after teams."
"We're under no illusions how tough it will be on the night, but if we can get the win then it gives us a great chance to win the league at home on Saturday. If we don't win then we get on with it, you know me, that's how I always approach things, but what a good day it would be at the DW Stadium on Saturday if we do win on Tuesday night.
"It would be such a good day to get a big crowd in on Saturday and celebrate in front of our own fans with everyone and their families. It would be great, but if not, we carry on."
"There will be one or two changes from Saturday. We can't keep going with the same team Saturday-Tuesday-Saturday-Tuesday as this time of year."
"Michael Jacobs was rested on Saturday with the intention of bringing him on at 60 minutes. It was good because we spoke to Michael and said we're OK in the game so you can have a full rest. Michael Jacobs comes back into the team against Bristol Rovers, that's the luxury that we have in our squad.


Even some of the most environmentally conscious people find it hard to give up drinking flavored bottled water. And even for them lies a solution in water filtration.
You've heard us say over and over that bottled water is expensive and bad for the environment. Bottled water advocates argue that their product provides a healthier option than sodas or other sugary beverages, and a ban on the bottle would only force people to turn to such less-healthy alternatives. Moreover, many people can't live without their daily dose of flavored water, which, up until recently, only came in a bottle. But with PUR flavor options, consumers are left with no more excuses to drink bottled water, flavored or not.
We recently added the PUR line of faucet filters and water pitcher filters to our website. (Actually, I must confess, they have been on the site for a few months now, so this announcement is a little late… but, better late than never, right?) The PUR flavored water pitcher filter and the PUR faucet mount filter with flavor options both reduce or remove harmful impurities and contaminants such as lead, mercury, cadmium, copper and microbiological cysts, in addition to the bad taste and odor of chlorine. How do you get flavored water from these filters? Very simply. Specially-made flavor cartridges allow you the option of adding a burst of strawberry, lemon, grape or raspberry flavor to each glass of purified water with the push of a button. The more you push, the more flavor is added. Each PUR flavor cartridge provides up to 75 servings of flavored water and contains no sugar, calories or dyes. The cartridges fit easily into the lid of the PUR water filter pitcher or into the front of the PUR flavor options faucet mount.
Pure, filtered water is the healthiest way to go. However, if you must drink flavored water, you can do your part to conserve the health of our planet by dropping the bottle in favor of a PUR filter with flavor options.


text:
package org.dashbuilder.renderer.chartjs.resources.i18n;

import com.google.gwt.core.client.GWT;
import com.google.gwt.i18n.client.Messages;

public interface ChartJsDisplayerConstants extends Messages {

    public static final ChartJsDisplayerConstants INSTANCE = GWT.create( ChartJsDisplayerConstants.class );

    String common_Categories();

    String common_Series();

    String common_Values();

    String common_Value();

    String common_Locations();

    String common_Rows();

    String common_Columns();

    String common_noData();

    String chartjsDisplayer_resetAnchor();
}


Purina ONE Adult Mini Fillets in Gravy is a delicious wet feed for cats aged 1 to 7. The fibres ensure your cat has a healthy digestive system.
The high moisture content helps your cat increase her water intake and the high quality meat & fish is a healthy source of protein that helps support a healthy digestive system.
The recommended daily amounts should be adjusted to weather conditions, your cat's level of activity and its physical condition. Serve at room temperature. Clean, fresh water should always be available.
The website is easy to navigate and find what you want. Deliveries are consistent and reasonably priced, and above a certain amount you get it delivered for free. Sweet. Once there was a problem with our order, we phoned the company and the customer service was absolutely legendary. The lady, her name was Morgan, understood the issue within 3 seconds and devised a creative solution within 2 seconds. We were so happy.It's worth everything. This is what successful companies are made of.
I ordered Purina Pouches and they arrived the next day. Always good service and much, much cheaper than supermarkets with free delivery.
Since feeding my cat this, her coat has improved and she is more content. Great service from Pet Supermarket at a much cheaper price than a supermarket. Would highly recommend.
I always buy Purina because since using it, my cat's coat is shiny and she is happy. I wouldn't buy from a supermarket any more as each box is about 60 pence cheaper from Pet Supermarket.
I will always buy from Pet Supermarket now, as they are so much cheaper than supermarkets. The delivery is very fast and, even better, free! Using Purina, I can see a noticeable difference in my cats fur, and she loves the taste.


Introducing GCON Custom Homes' new website. It is also Responsive so no matter what device you view our website from, you can easily navigate through it.
Thanks Pivotal Marketing Partners for our new site!


text:
Isham Park est un parc d'environ 2,5 hectares situé dans le quartier d'Inwood, dans le nord de Manhattan, à New York, États-Unis. Localisé à deux pas d'Inwood Hill Park, Isham Park est entouré par Broadway, Isham Street, Seaman Avenue et les   et  .
Le parc est surtout connu pour sa partie méridionale où des affleurements de  marbres datant de la période cambrienne sont visibles.

Histoire
En 1864, , un riche marchand de cuir, acheta le terrain de l'actuel Isham Park. En 1912, la fille d'Isham, Julia Isham Taylor fit don d'une partie de sa propriété à la ville, en mémoire de son père. La fille de Julia Isham Taylor, Flora, fit de même en 1916. La ville acquit également des terrains en 1925 et 1927, ce qui permit de créer Isham Park. Ces achats successifs expliquent pourquoi le parc a une forme irrégulière.

Notes et références

Liens externes
 Isham Park sur Google Earth
  Isham Park sur le site de la mairie de New York

Parc ou jardin public à New York

redpajama_set_name: RedPajamaWikipedia


yeah, your are waiting the all week, you are training your chao for hour and hours!!!!
you want the gold medal, you want the first place, you want the 4000 green hill points, you want win!!!!
now, the chao contest its open!!!
okey, firts you need host your video and pic, you can host in facebook or its you have a youtube channel you can host here!!
and tomorrow the judges rank to your chaos and say the winners!!!
and that win the best, please dont are a bad loser and bad winner, you accustom win and you accustom lose, please dont are be angry its you lose and dont are a bad guy with the loser its you win!!!


When writing a dissertation thesis you are sure to perform a critical overview of literature sources on the topic of your scientific research. Though it is not a difficult task to do, for many people it is rather a problem.
Make clear if you know what you are going to write about. Define the object and subject of your research, make the list of main objectives and perspectives that will make a dissertation plan. This step will save you a lot of time and efforts as you will know what sources to analyze instead of reading everything you have found.
Get the ability to find relevant material that has scientific novelty. To do this you should use not only printable recourses but also online ones. Surf the net to find material you need, read critical reviews of other people, visit online libraries to get an advice, get access to scientific data bases.
Remember that a literature overview is not just a chronological description of works of other people whose works you have read. It must be written in a scientific style where you analyze each source pointing out how the problem of your dissertation thesis was investigated by different researches or scientists. On this basis you note what aspects of the problem were left aside and in this way the scientific novelty of your dissertation is proved.
Use a critical approach to the analysis of what you are writing. It's not a story or a literary essay but a critical review which is drawn through your own perception and interpretation.
Avoid colloquial and personal language styles. Your writing must be clear and coherent. Don't use the language of emotions. You should be always objective and respect other people opinions. Use categorization to present your findings.
Make use of works performed by modern scientists. All material you use must be valid.
Present conclusion based on your analysis when you have identified the key themes and issues. You must state which approach is more appropriate and which is less, which of them dominates now and why, what ideas and scientific approaches you support. Your literature overview together with the research problem should lead to empirical questions formulation. In fact, you should explain with the help of your literature overview, how your research makes a contribution to a given field of scientific knowledge.


The event offered two options - casual poker run and more competitive endurance challenge, which I signed up for and was all about completing as many of the outer 3.5 mile laps as you could in under four hours. Steve and I lined up along with around ten other riders and off we went with Steve hitting the single track in first place, with me right behind him. About one minute in, we were getting ready to hit the long climb on the eastern side of the park, and I was feeling great so I called out to Steve that I was coming around him at one of the few passing spots. My plan was to hit the climb crazy hard to shake things up a bit - the conditions were such, that you could only ride on a 12 inch wide path that had been compacted by walkers and snowshoers, outside of that was a out a foot of snow that would stop you dead in your tracks. So once we started the climb, anyone who was behind a slower rider would be stuck. So I figured by going hard, I would probably have Steve and possibly one other person come with me before the inevitable gap would occur. Because of the narrow track, looking back was a bad idea lest you would get off track, so I just went hard having no clue what was going on behind me. By the time we exited the climb and single-track a quick check showed Steve on my wheel with nobody else in sight, SWEET! And that's pretty much how things stayed for the rest of the race, with Steve and me changing positions lap by lap, and cranking. First couple of laps we went at more of an XC race pace to solidify our lead, and then when we asked Greg at one of the checkpoints how much of a lead we had and he confirmed laughingly "at least five minutes", we settled into a healthy endurance pace and did our thing. Lap times were a consistent 20 minutes, conditions were fast rolling, with a few tricky soft spots and icy sections, both of which got worse as the morning went on. Unfortunately Steve had to pull off 12:15 to get to work, leaving him one lap short of the 10 laps the three podium finishers completed; I'm pretty sure we lapped everyone else in our field with a 12 minute gap to second place. Was definitely awesome to be riding out front with a fellow Bulldog, just a bummer that we weren't able to share the victory. Now I'm really ready for this stubborn winter to be over.


"Remember that sometimes not getting what you want is a wonderful stroke of luck".
I can imagine at least a hundred of book titles that promise to reveal one of the biggest secrets: how to get what you want. It's like a cake recipe. Everyone claims that have the perfect recipe, but in the end all have almost the same materials, only proportions change. The result depends upon the same factors: good materials, well-functioning devices, excellent and precise performance, people to taste it and appreciate it, coincidence in gastronomic preferences.


text:
Comparison of the effects of aminosugar cardiac glycosides wth ouabain and digoxin on Na+, K+ adenosine triphosphatase and cardiac contractile force
R. W. Caldwell, C. B. Nash
Two aminosugar cardiac glycosides, 3-β-O-(4-amino-4,6-dideoxy-β-D-galactopyranosyl) digitoxigenin (ASI-222) and its 4-aminoglucose analog (ASI-254) have been shown in our laboratory to have a greater therapeutic index than ouabain (O) or digoxin (D). We have now compared the ability of ASI-222, its nonamino galactose analog (ASI-253), ASI-254, ouabain and digoxin to inhibit swine brain Na+,K+-adenosine triphosphatase (Na+,K+-ATPase) and to increase contractile force of isolated, driven rabbit atria. As inhibitors of Na+,K+-ATPase, both ASI-222 and ASI-254 were found to be about 10 times more potent than ASI-253, O or D (I50: ASI-222, 1.3 x 10-7 M; ASI-254, 1.4 x 10-7 M; ASI-253, 1.15 x 10-6 M; D, 1.6 x 10-6 M; O, 1.75 x 10-6 M). Moreover, the potency of these glycosides in inhibiting Na+,K+-ATPase correlates closely with the ability of these same glycosides to increase contractile force. The concentration needed to obtain 50% of the maximum increase in contractile force was 9.7 x 10-8 M for ASI-254, 1.5 x 10-7 M for ASI-222, 8.8 x 10-7 M for ASI-253, 8.4 x 10-7 M for O and 1.2 x 10-6 M for D. Since ASI-253, a nonaminogalactose analog of ASI-222, exhibits a potency in both of our test systems which is similar to the other neutral sugar cardenolides our data also indicate that the presence of an aminosugar group at position 4 of a sugar in a cardiac glycoside confers greater potency.
Fingerprint Dive into the research topics of 'Comparison of the effects of aminosugar cardiac glycosides wth ouabain and digoxin on Na+, K+ adenosine triphosphatase and cardiac contractile force'. Together they form a unique fingerprint.
ASI-222 Medicine & Life Sciences
ASI 254 Medicine & Life Sciences
Cardiac Glycosides Medicine & Life Sciences
Digoxin Medicine & Life Sciences
Ouabain Medicine & Life Sciences
Glycosides Medicine & Life Sciences
Sugars Medicine & Life Sciences
Caldwell, R. W., & Nash, C. B. (1978). Comparison of the effects of aminosugar cardiac glycosides wth ouabain and digoxin on Na+, K+ adenosine triphosphatase and cardiac contractile force. Journal of Pharmacology and Experimental Therapeutics, 204(1), 141-148.
Comparison of the effects of aminosugar cardiac glycosides wth ouabain and digoxin on Na+, K+ adenosine triphosphatase and cardiac contractile force. / Caldwell, R. W.; Nash, C. B.
In: Journal of Pharmacology and Experimental Therapeutics, Vol. 204, No. 1, 01.01.1978, p. 141-148.
Caldwell, RW & Nash, CB 1978, 'Comparison of the effects of aminosugar cardiac glycosides wth ouabain and digoxin on Na+, K+ adenosine triphosphatase and cardiac contractile force', Journal of Pharmacology and Experimental Therapeutics, vol. 204, no. 1, pp. 141-148.
Caldwell RW, Nash CB. Comparison of the effects of aminosugar cardiac glycosides wth ouabain and digoxin on Na+, K+ adenosine triphosphatase and cardiac contractile force. Journal of Pharmacology and Experimental Therapeutics. 1978 Jan 1;204(1):141-148.
Caldwell, R. W. ; Nash, C. B. / Comparison of the effects of aminosugar cardiac glycosides wth ouabain and digoxin on Na+, K+ adenosine triphosphatase and cardiac contractile force. In: Journal of Pharmacology and Experimental Therapeutics. 1978 ; Vol. 204, No. 1. pp. 141-148.
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abstract = "Two aminosugar cardiac glycosides, 3-β-O-(4-amino-4,6-dideoxy-β-D-galactopyranosyl) digitoxigenin (ASI-222) and its 4-aminoglucose analog (ASI-254) have been shown in our laboratory to have a greater therapeutic index than ouabain (O) or digoxin (D). We have now compared the ability of ASI-222, its nonamino galactose analog (ASI-253), ASI-254, ouabain and digoxin to inhibit swine brain Na+,K+-adenosine triphosphatase (Na+,K+-ATPase) and to increase contractile force of isolated, driven rabbit atria. As inhibitors of Na+,K+-ATPase, both ASI-222 and ASI-254 were found to be about 10 times more potent than ASI-253, O or D (I50: ASI-222, 1.3 x 10-7 M; ASI-254, 1.4 x 10-7 M; ASI-253, 1.15 x 10-6 M; D, 1.6 x 10-6 M; O, 1.75 x 10-6 M). Moreover, the potency of these glycosides in inhibiting Na+,K+-ATPase correlates closely with the ability of these same glycosides to increase contractile force. The concentration needed to obtain 50% of the maximum increase in contractile force was 9.7 x 10-8 M for ASI-254, 1.5 x 10-7 M for ASI-222, 8.8 x 10-7 M for ASI-253, 8.4 x 10-7 M for O and 1.2 x 10-6 M for D. Since ASI-253, a nonaminogalactose analog of ASI-222, exhibits a potency in both of our test systems which is similar to the other neutral sugar cardenolides our data also indicate that the presence of an aminosugar group at position 4 of a sugar in a cardiac glycoside confers greater potency.",
author = "Caldwell, {R. W.} and Nash, {C. B.}",
journal = "The Journal of pharmacology and experimental therapeutics",
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T1 - Comparison of the effects of aminosugar cardiac glycosides wth ouabain and digoxin on Na+, K+ adenosine triphosphatase and cardiac contractile force
AU - Caldwell, R. W.
AU - Nash, C. B.
N2 - Two aminosugar cardiac glycosides, 3-β-O-(4-amino-4,6-dideoxy-β-D-galactopyranosyl) digitoxigenin (ASI-222) and its 4-aminoglucose analog (ASI-254) have been shown in our laboratory to have a greater therapeutic index than ouabain (O) or digoxin (D). We have now compared the ability of ASI-222, its nonamino galactose analog (ASI-253), ASI-254, ouabain and digoxin to inhibit swine brain Na+,K+-adenosine triphosphatase (Na+,K+-ATPase) and to increase contractile force of isolated, driven rabbit atria. As inhibitors of Na+,K+-ATPase, both ASI-222 and ASI-254 were found to be about 10 times more potent than ASI-253, O or D (I50: ASI-222, 1.3 x 10-7 M; ASI-254, 1.4 x 10-7 M; ASI-253, 1.15 x 10-6 M; D, 1.6 x 10-6 M; O, 1.75 x 10-6 M). Moreover, the potency of these glycosides in inhibiting Na+,K+-ATPase correlates closely with the ability of these same glycosides to increase contractile force. The concentration needed to obtain 50% of the maximum increase in contractile force was 9.7 x 10-8 M for ASI-254, 1.5 x 10-7 M for ASI-222, 8.8 x 10-7 M for ASI-253, 8.4 x 10-7 M for O and 1.2 x 10-6 M for D. Since ASI-253, a nonaminogalactose analog of ASI-222, exhibits a potency in both of our test systems which is similar to the other neutral sugar cardenolides our data also indicate that the presence of an aminosugar group at position 4 of a sugar in a cardiac glycoside confers greater potency.
AB - Two aminosugar cardiac glycosides, 3-β-O-(4-amino-4,6-dideoxy-β-D-galactopyranosyl) digitoxigenin (ASI-222) and its 4-aminoglucose analog (ASI-254) have been shown in our laboratory to have a greater therapeutic index than ouabain (O) or digoxin (D). We have now compared the ability of ASI-222, its nonamino galactose analog (ASI-253), ASI-254, ouabain and digoxin to inhibit swine brain Na+,K+-adenosine triphosphatase (Na+,K+-ATPase) and to increase contractile force of isolated, driven rabbit atria. As inhibitors of Na+,K+-ATPase, both ASI-222 and ASI-254 were found to be about 10 times more potent than ASI-253, O or D (I50: ASI-222, 1.3 x 10-7 M; ASI-254, 1.4 x 10-7 M; ASI-253, 1.15 x 10-6 M; D, 1.6 x 10-6 M; O, 1.75 x 10-6 M). Moreover, the potency of these glycosides in inhibiting Na+,K+-ATPase correlates closely with the ability of these same glycosides to increase contractile force. The concentration needed to obtain 50% of the maximum increase in contractile force was 9.7 x 10-8 M for ASI-254, 1.5 x 10-7 M for ASI-222, 8.8 x 10-7 M for ASI-253, 8.4 x 10-7 M for O and 1.2 x 10-6 M for D. Since ASI-253, a nonaminogalactose analog of ASI-222, exhibits a potency in both of our test systems which is similar to the other neutral sugar cardenolides our data also indicate that the presence of an aminosugar group at position 4 of a sugar in a cardiac glycoside confers greater potency.
JO - The Journal of pharmacology and experimental therapeutics
JF - The Journal of pharmacology and experimental therapeutics


text:
Xiaomi Mi Pad price permanently slashed to Rs. 10999
By Jonathan Pereira	 On Jan 16, 2016
While Xiaomi was offering temporary price cuts on the Mi Pad, the company has now announced a permanent price cut on the tablet.
Xiaomi has announced a permanent price cut for the Mi Pad in India. While the tablet was launched at Rs. 12999, it is now priced at Rs. 10999, which means a discount of Rs. 2000. The new prices are applicable on all purchases made on the company's website and Flipkart. Given the price cut, we can assume that the company is gearing up to launch the next gen Mi Pad 2 in India soon.
The Xiaomi Mi Pad has a 7.9 inch display with Corning Gorilla Glass 3 protection and resolution of 2048 x 1536 pixels. The tablet is powered by the NVIDIA Tegra K1 processor with 2 GB of RAM and 16 GB of storage. The device is equipped with an 8 MP rear facing camera and a front facing 5 MP camera. The tablet sports a massive 6700 mAh battery.
BSNL reduces calling rates for existing prepaid customers by 80 percent
Lenovo K5 Note with full metal body and fingerprint scanner passes TENAA certification