text:
Top Venice Art & Culture
690 results | All Venice Tours
Venice Ghost and Legends Walking Tour
As night falls on Venice and the crowds disappear, discover the city's darkest secrets on this devilishly entertaining ghost tour. Wander through narrow passageways and past the blackened, vacant canals to uncover Venice's haunted history. Listen to your ghost-hunter guide spin tales about the sinister deeds and tragic ends of the figures who once walked the streets—some of whom are believed to still wander as restless spirits.
Venice Carnival Mask-Making Class
Take a course on mask making from a master artisan in Venice, and learn about the history of this ancient tradition. You can choose from a production class or a decoration class, or you can even take both. In the production class, learn how to make your own papier-mâché mask, and in the decoration class, you can paint or use materials to decorate your mask. No matter which option you choose, you get to bring home your creation—just in time for Carnival.
I Musici Veneziani Concert: Baroque and Opera
Pay homage to the golden age of Venice with a night at the opera. Enjoy a thrilling program of baroque classics and operatic arias, performed by the orchestra and singers of I Musici Veneziani. The show whisks you back to 18th-century Venice, with performers dressed in traditional Venetian costumes and a spectacular setting in the exclusive Salone Capitolare at the Scuola Grande di San Teodoro.
Murano Glass Factory Experience: Factory Tour and Workshop
Get an inside peek into the world-famous glassblowing factories of Murano on a 2-hour escorted tour. Meet your guide in central Venice, and ride a water bus across the Venetian Lagoon to the colorful island of Murano. Get a private glassmaking demonstration from a master craftsman, and enjoy time to browse the factory showroom featuring finished works of art. Finally, attend your choice of hands-on workshop to create a take-home piece of jewelry or mosaic using authentic Murano glass.
Create your glass artwork: private lesson with local artisan
Get hands-on experience with one-to-one guidance during a private glassmaking lesson. Discover the secrets of Murano glassmaking techniques from one of the most renowned craftsmen of Venice. The 90-minute workshop includes all materials—including your own marvelous glass artwork to take home—plus a 10 percent discount on glassworks from the artist.
Doge's Palace & Prisons Ticket and Tour
Experience the magnificence and mystery of the Doge's Palace in Venice with this skip-the-line ticket. Head to the front of the queue with your guide, and then wander through the palace's ornate public rooms as you learn the history of Venice's powerful rulers. Admire magnificent interior artwork, including Renaissance masterpieces by painters Tintoretto and Veronese. Explore the palace's darker side with a visit to the prison quarters and a walk across the notorious Bridge of Sighs.
Venice Murano Island Glass Factory Tour with Glass Blowing Demonstration
Get an inside look into the centuries-old art of glassblowing with a factory tour on Murano Island, home to the world's finest artisan glass. Tour the facilities at Colleoni Glass Factory and watch a master craftsman shape molten glass through a combination of heat, blowing and sculptural techniques. Visit the factory showroom to see beautiful finished works of art, and receive a special Murano glass souvenir to take home.
Underground Venice
Beneath Venice's waterfront palazzos, palaces, and churches lies an underground crypt filled with skulls and a mysterious painted skeleton. This walking tour takes you into the depths beneath Venice, where your guide will show you the hidden tomb—complete with religious frescoes and dark recesses. Then, explore two Venetian districts and learn about the city's dark history of curses, revenge, and mysterious apparitions.
Musica a Palazzo 'Traveling Opera' Performance in Venice
Experience an evening of opera in Venice, surrounded by the historical elegance of a 15th-century palace. The singers and musicians of the Musica a Palazzo ensemble perform classics of Italian opera within the ornate salons of Palazzo Barbarigo Minotto. Move from room to room along with the performers and soak up the drama of epics like 'La Traviata' and 'Rigoletto' in a truly intimate environment.
I Musici Veneziani Concert: Vivaldi Four Seasons
Hear Antonio Vivaldi's magnificent 'Four Seasons' performed by Venice's acclaimed I Musici Veneziani. The 1.5-hour show will whisk you back to 18th-century Venice, with performers dressed in traditional Venetian costumes and a spectacular setting in the exclusive Salone Capitolare at the Scuola Grande di San Teodoro.
Teatro La Fenice Tour in Venice
Step back in time to the golden age of Italian opera with this guided tour of Venice's Teatro La Fenice. Learn the history and legends of this decadent Baroque opera house, which was once the heart of Venetian high society and hosted performances by masterful maestros like Verdi, Rossini and Bellini.
Mystery in Venice: Legends and Ghosts of the Cannaregio District
When night falls across Venice, uncover a shadowy world of restless spirits and Old World legends on this 2-hour ghost tour of the historic Cannaregio district. Discover sinister tales that haunt the city's former Jewish ghetto as you stroll through hidden backstreets and lamplit squares, listening to your guide's retelling along with the gently lapping water of darkened canals.
Interpreti Veneziani Ensemble Baroque Concert in Venice Ticket
Immerse yourself in the sights and sounds of baroque music at this authentic chamber performance in Venice. The 17th-century Church of San Vidal provides an intimate historic setting and fantastic acoustics for concertos and symphonies by European masters such as Mozart, Bach, Vivaldi, and Handel. The talented members of the Interpreti Veneziani ensemble bring these musical masterworks to life for a night out you won't soon forget.
Ghosts of Venice - Discovering the unknown
After the sun has set and the tourist crowds have departed, the mysterious side of Venice becomes apparent. Discover the myths and hauntings surrounding the popular city on a 90-minute ghost tour. Follow your guide through deserted squares, down quiet alleyways, and into the past. Learn about local legends, unexplained events, and of course, ghost stories that have been passed down through generations.
Watercolors in Venice: painting class with famous artist
Take a break from the usual sightseeing and snapping photos in Venice with this special experience that allows you to be an artist for the day. A local Venetian artist takes you to find the ideal corner of the city to paint, where you can create your own artwork with watercolors.
Venice glassblowing - Small group
Learn the secrets of glassblowing during this activity in Venice. On the island of Murano, visit the Glass Factory Showroom near St Mark's Square to see examples of this highly specialized glass art, beloved by collectors the world over. Learn about this technique's origins in the Roman Empire from you guide, then watch a glassblowing demonstration by a Master Artisan. Walk away with a small Murano glass souvenir.
Interpreti Veneziani Concert in Venice Including Music Museum
Take a musical adventure in Venice with a concert by Interpreti Veneziani and a visit to the city's music museum. Learn about the legacy of Vivaldi, a Venetian composer who left a distinct mark on the canal city, and see string instruments from the 17th-19th centuries in the Music Museum housed inside the San Maurizio Church. Listen later that evening as the Interpreti Veneziani ensemble performs works by such famous composers as Handel, Bach and Mozart.
Legendary Venice St. Mark's Basilica and Doge's Palace Group or Private Tour
Delve into Venetian history on this tour that showcases two of the city's most iconic structures and sheds light on the stories behind them both. Enjoy skip-the-line access to both popular attractions. Your first stop is legendary St. Mark's Basilica. Wander around the mosaic-covered interior and Byzantine treasures while a local guide fills you in on how this collection came to be. Then continue to the Doge's Palace to explore the former political heart of Venice.
Venice Private Mask Workshop
For this private mask-decorating workshop in Venice, arrive at a traditional atelier, and get a blank sand-colored mask that's ready for your artist eye. Use feathers, sequins, and other materials to make a masterpiece. Your guide will share facts about the history of mask making and can also show you some great techniques to use. Afterward, you'll get to bring home your decorated mask.
Avanspettacolo: Cabaret Dinner Show in Venice
For a special night out while vacationing in Venice, book an entertaining evening out at the cabaret. A grand magic show, musical performers, and dancers keep you entertained while you dine on a multi-course international dinner with Italian wine. Choose from among three different menus; a welcome cocktail is included.
Murano by Private Watertaxi Including Glass Blowing Demo with Hotel Pickup
Visit the famed glassblowing island of Murano via private water taxi, and watch glass artisans at work. Explore the seventh century cathedral in Murano's historical center before learning about the skill required to blow glass. Step inside a traditional glass factory for a full demonstration, peruse showrooms, take advantage of discounts on glassware, and slip your foot into a glass slipper. If it's your size, you'll walk away with a specially made souvenir crafted from Venetian glass.
Venice Super Saver: Skip-the-Line Doge's Palace and St Mark's Basilica Tours plus Venice Walking Tour
See two of Venice's most iconic attractions and save 10% when you book them together with this Super Saver. Head to the front of the long queues with skip-the-line access to the famed Doge's Palace and St Mark's Basilica. Learn the history behind these architectural wonders from your local guide, and explore some of Venice's lesser-known sights on a walking tour. Complete both tours in the same day with a break in between to spend at your leisure, depending on the operational schedule.
Venice: The Ghost & Legends Walking Tour
Learn about Venice's murders, mysteries, superstitions, and ghosts on this exciting evening tour. Wandering around Venice's maze of cobblestoned alleyways at night can make it easy to get lost, but you won't have to worry, as your guide will lead the way. Get your bearings of the city as you hear about tales of the unexpected. It's a fun way to explore the Cannaregio and Castello districts while being entertained with Venice's ghost stories.
Murano, Burano and Torcello Half-Day Sightseeing Tour
Visit Torcello, Murano, and Burano—three islands in the Venetian Lagoon—on this tour from Venice by motorboat. With a guide, watch glass being blown at a Murano glass factory, see historical cathedrals on Torcello, and admire exquisite handmade lace on Burano. This is a great way to see more than just the central sights of Venice and enjoy a cruise on the water. Select a departure time when booking.
What are the best Art & Culture in Venice?
The best Art & Culture in Venice according to Viator travelers are:
See all Art & Culture in Venice on Viator.
What Art & Culture in Venice are 1 hour or less?
Art & Culture in Venice that are 1 hour or less are:
What Art & Culture in Venice are taking additional safety precautions?
These Venice experiences are providing additional COVID-19 safety measures:
What Art & Culture in Venice are good for avoiding crowds?
These hidden gems in Venice may have limited interaction with crowds:


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Q: grails: How to map one to many relationship with composite ForeignKey I have a pre-existing database with two tables FileContainer and FileObjects. FileContainer has a composite primary key of clientId and fileContainerId. FileContainerId is unique per client. FileObjects also has a composite primary key of clientId(FileContainerClientId) and fileObjectId. FileContainer and FileObjects has a one to many relationship. Foreign Key Relationship is having multiple columns(clientId and fileContainerId). So my Domain classes look like the following.
class FileContainer implements Serializable {

  BigDecimal clientId
  BigDecimal fileContainerId
  ...
  ...
  static hasMany = [fileObjects: FileObject]

  static mapping = {
    table 't_container'
    id composite : ["clientId", "fileContainerId"]
  }
}

class FileObject implements Serializable {

  BigDecimal FileContainerClientId
  BigDecimal fileObjectId
  FileContainer fileContainerId
  ...
  ...
  static belongsTo = [FileContainer]

  static mapping = {
    table 't_file_object'
    id composite : ["FileContainerClientId", "fileContainerId"]
    column fileContainerId: 'custom_name_container_id'
    column FileContainerClientId: 'client_id'
  }
}

But unfortunately above Domain classes fails validation and give the following exception with text org.hibernate.MappingException: 'Repeated column in mapping for entity: FileObject column: file_container_client_id (should be mapped with insert="false" update="false")'.
I tried using a custom UserType consisting of columns (client_id and file_container_id). But got all sorts of different errors.
How should domain classes be created in this case ?
Also, If somebody can give an example of using org.hibernate.usertype.UserType that would be helpful.
===============================================================
Also tried the following in the FileObject class.
class FileObject implements Serializable {

  BigDecimal clientId
  BigDecimal fileObjectId
  BigDecimal fileContainerId
  ...
  ...
  static belongsTo = [fileContainer: FileContainer]

  static mapping = {
    table 'file_object'
    id composite : ["FileContainerClientId", "fileContainerId"]
    column fileContainerId: 'custom_name_container_id'
    column clientId: 'client_id'
    fileContainer column: 'client_id'
    fileContainer column: 'file_container_id'
  }
}

But got the missing file_container_client_id column exception.
=========================================================================
Since the FileContainerClientId in Object class is a foreign key to clientId in Container class, it should never be inserted or updated directly, it should always come from FileContainer class. Going by the above logic, I tried adding the following mapping
static mapping = {
  FileContainerClientId insertable: false
  FileContainerClientId updateable: false
}

but Compile failed since the property name starts with capital letter. If I change the property name to fileContainerClientId then it compiles but cannot map the column to foreignKey and throws a missing file_container_client_id column exception during validation

A: The following code can be used to map such cases.
class FileContainer implements Serializable {

  BigDecimal clientId
  BigDecimal fileContainerId
  ...
  ...
  static hasMany = [fileObjects: FileObject]

  static mapping = {
    table 't_container'
    id composite : ["clientId", "fileContainerId"]
  }
}

class FileObject implements Serializable {

  BigDecimal clientId
  BigDecimal fileObjectId
  BigDecimal fileContainerId
  FileContainer fileContainer
  ...
  ...
  static belongsTo = [FileContainer]

  static mapping = {
    table 't_file_object'
    id composite : ["clientId", "fileObjectId"]
    columns {
        fileContainer {
            column name:'client_id'
            column name:'file_container_id'
        }
    }
    fileContainer insertable:false, updateable:false

  }
}

redpajama_set_name: RedPajamaStackExchange


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Home » Anime / Manga » Attack on Titan Season 4 Part 2, Release Date and Timing – Where can you watch the anime?
Attack on Titan Season 4 Part 2, Release Date and Timing – Where can you watch the anime?
Attack on Titan Season 4 Part 2 is finally here. After almost a year of waiting, many anime fans are excited to finally see the second season of Attack on Titan.
Attack on Titan Season 4's first season had 16 episodes. The second half will have the same number of episodes. Finally, the finale of the battle between Armored Titan and Attack will be shown. The series, which was created by Hajime Isayama (a Japanese manga artist who is also well-known for his work on Attack on Avengers and The Killing Pawn), premiered on Crunchyroll for the first time in 2013.
After season 1 and 2 were released on Netflix respectively, the Series was named. Since then, anime fans all over the world have enjoyed the series immensely.
We now have all the details about Attack on Titan Season 4 Part 2! A few weeks ago, the official trailer for the anime series was also released.
What is the Release Date and Time of Attack On Titan Season 4 Part 2?
Release Time in different timezones
Episode details for Attack on Titan Season 4 Part 2.
What is the Part of the Season like?
Finaly, the second episode of Attack on Titan Season 4 will be available on Crunchyroll or Funimation at 12:05 PM JST according to Japanese standard time.
See also Family Guy Season 20: All We Know About Release Date and Plot
The anime's first episode was titled "Judgment" (in English). The series will be available in Japanese, but English subtitles will be provided so that fans from the USA, UK, Australia and Europe can enjoy it.
Fans will have to wait one month for the English dubbed version. The series will then be available in English on Netflix.
We have all the details.
Pacific Time, 12:45 PM on January 9, 2022
Central Time, 2:45 PM January 9, 2022
Eastern Time, 3:45 PM January 9, 2022
British Time, 8:45 PM January 9, 2022
At 9:45 PM in European Time on January 9, 2022
Indian Time, 2:15 AM January 10, 2022
Season 4 Part 2 will contain 12 episodes. We will receive a new episode on Crunchyroll or Funimation every Sunday. We will also receive a new episode on Sundays, as mentioned above.
AoT Part 02 episode 02
Title: Sneak Attack.
— SPY (@_Dominating) January 1, 2022
Season 4 Part 2's storyline will begin at the end of its part 2. Episode 17 will then tell the story of episode 16. In episode 16, Eren received an offer to join Jaegerists. In the video below we discuss what could happen in season 2 of anime.
See also 20 Surprising Facts about All Might
Daredevil Season 4: Will Jessica Jones and Iron Fist, Punisher, or Luke Cage return??
Undercover Season 3 Episode 8 – Episode and Cast Details Available on Netflix Today

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Baby, It's Cold Outside (Liebling, es ist kalt draußen) ist ein Popsong. Text und Musik stammen von Frank Loesser. Loesser schrieb das Duett 1944 und führte es zuerst mit seiner Frau, Lynn Garland, auf. In dem Lied möchte eine Person die andere gerade verlassen, um nach Hause zu gehen, und wird von dieser zum Bleiben überredet. Verschiedenste vorgebrachte Argumente werden nach und nach – teils recht fadenscheinig – zu entkräften versucht.

Übersicht
Es gibt zahlreiche Einspielungen und Arrangements des Songs.

1949 wurde das Lied im Film Neptuns Tochter von Ricardo Montalbán und Esther Williams aufgeführt. Für diese Version erhielt Loesser bei der Oscarverleihung 1950 den Oscar für den besten Song.

Eine deutschsprachige Textfassung unter dem Titel Baby, es regnet doch wurde von Ralph Maria Siegel verfasst. Sie wurde unter anderem von Rita Paul und Peter Cornehlsen (1949), Rita Paul und Bully Buhlan (1950), Renée Franke und Heinz Erhardt (1950), Ruth Zillger und Ilja Glusgal (1950), Evelyn Künneke und Erwin Halletz (1951), Nana Gualdi und Fred Weyrich (1965), Greetje Kauffeld und Bully Buhlan (1973), Marika Lichter und Gerhard Bronner (1978) sowie Gunther Emmerlich und Rosay Wortham (1990) interpretiert. Eine weitere deutschsprachige Fassung unter dem Titel Mach's gut, ich muß geh'n aus der Feder von Manfred Krug wurde von Manfred Krug zusammen mit Beate Barwandt (1974), Fanny Krug (2001) sowie mit Uschi Brüning (2014) aufgenommen. Der Diskograf Tom Lord listet im Bereich des Jazz insgesamt 85 (Stand 2017) Coverversionen, u. a. von Johnny Mercer, Ella Fitzgerald, Cab Calloway, Pearl Bailey, Svend Asmussen, Louis Armstrong, Sammy Davis, Jr., Neal Hefti, Ray Charles, Ted Heath, Jimmy Smith, Shirley Scott/Kenny Burrell, Dianne Reeves/Lou Rawls und Ben Webster.

Varia
Der Radiosender Star 102 Cleveland strich den Song am 2. Dezember 2018 aus dem Programm. Als Grund werden Beschwerden angegeben, der Song sei in Zeiten von MeToo nicht mehr vertretbar. Er sei sexistisch und latent sexuell übergriffig.
John Legend und Kelly Clarkson schrieben daraufhin das Lied im Jahr 2019 um.

Charts und Chartplatzierungen

Version von Dinah Shore & Buddy Clark

Version von Margaret Whiting & Johnny Mercer

Version von Don Cornell & Laura Leslie

Version von Ella Fitzgerald & Louis Jordan

Version von Ray Charles

Version von Tom Jones & Cerys Matthews

Version von Glee Cast

Version von Idina Menzel & Michael Bublé

Version von Brett Eldredge feat. Meghan Trainor

Version von Dean Martin

Weblinks
 Liedtext

Einzelnachweise

Popsong
Weihnachtslied
Jazz-Titel
Lied 1944
Frank Loesser
Ray Charles

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Some music brings happiness and joy, contentment and hope, but some music has dire consequences. And you must know that these consequences are madness and death. When Dylan McAllister finds a notebook hidden in a secret compartment of an old piano, he soon discovers a music that should never be heard by human ears.
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text:
package org.quartz.utils;

import java.util.Properties;

import junit.framework.TestCase;

/**
 * Unit tests for PropertiesParser.
 */
public class PropertiesParserTest extends TestCase {

    /**
     * Unit test for full getPropertyGroup() method.
     */
    public void testGetPropertyGroupStringBooleanStringArray() {
        // Test that an empty property does not cause an exception
        Properties props = new Properties();
        props.put("x.y.z", "");

        PropertiesParser propertiesParser = new PropertiesParser(props);
        Properties propGroup = propertiesParser.getPropertyGroup("x.y", true, new String[] {});
        assertEquals("", propGroup.getProperty("z"));
    }
}

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On July 4, 2018, Timehop experienced a network intrusion that led to a breach of some of your data. We learned of the breach while it was still in progress, and were able to interrupt it, but data was taken. While our investigation into this incident (and the possibility of any earlier ones that may have occurred) continues, we are writing to provide our users and partners with all the relevant information as quickly as possible.
To reiterate: none of your "memories" – the social media posts & photos that Timehop stores – were accessed.
Keys that let Timehop read and show you your social media posts (but not private messages) were also compromised. We have deactivated these keys so they can no longer be used by anyone – so you'll have to re-authenticate to our App.
If you have noticed any content not loading, it is because Timehop deactivated these proactively.
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text:
COVID-19 Updates and Information Following guidance from the White House, Centers for Disease Control and Prevention...
U.S. Department of the Interior Indian Affairs
Assistant Secretary - Indian Affairs
Bureau of Indian Education
Bureau of Trust Funds Administration
White House Council on Native American Affairs
Policy and Forms
IA Directives System
Regional Directives
Assistant Secretary's Orders
About Tribal Consultations
Regulations, Documents in Development
Former DAS-PED Mark Cruz
Mark Cruz, an enrolled member of the Klamath Tribes in Oregon, is the former Deputy Assistant Secretary–Indian Affairs for Policy and Economic Development (DAS-PED). He was appointed by former Assistant Secretary–Indian Affairs Tara Karuk Mac Lean Sweeney on September 24, 2018, and ended his tenure December 28, 2020.
Mr. Cruz came to the Interior Department after serving on Capitol Hill, as chief of staff to Representative Todd Rokita (R-Indiana) from 2017-2018 and on his legislative staff from 2014-2017. Prior to that office, from 2013-2014, he worked as a legislative fellow in the office of Representative Tom Cole (R-Oklahoma).
A Teach for America alum, Mr. Cruz taught at the St. Francis Indian High School, a Bureau of Indian Education tribal grant school, located on the Rosebud Sioux Indian Reservation in South Dakota. While there, he earned the 2011-2012 St. Francis Indian High School Teacher of the Year award.
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text:
How Organoids Are Fueling Infectious Disease Research and Personalized Medicine
Michele Trott, PhD
Michele Trott holds a PhD in endocrinology from Lincoln University. She works as a freelance science writer and scientific content manager for Izon Science.
Organoid grown from a single mammary stem cell. Credit: Geoffrey Wahl, Christopher Dravis, National Cancer Institute \ Salk Institute
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There are two fundamental questions that persist across all subfields of biology: "What are the cues that govern the formation and stability of the differentiated state, and can we recapitulate morphogenesis in culture?"1 These questions are important because having the ability to recapitulate tissue function and dissect disease progression in vitro opens many doors for drug discovery and allows researchers to explore questions that can't be answered in vivo.
Alongside efforts to recapitulate tissue function, there has been an increasing appreciation for the importance of 3D architecture in functional differentiation.1 While 2D cell cultures have been useful in many ways, they differ from in vivo conditions significantly, thereby making it difficult to translate findings to the clinic. Similarly, animal studies have been critical to enabling progress across healthcare sectors; however, species differences in absorption, distribution, metabolism, excretion and toxicity (ADMET) limit predictivity. Together with the notoriously high cost and failure rate of drug development, there is an urgent need for more predictive research models across all fields.
Here, we discuss organoids in the context of personalized medicine and infectious disease and explore how they provide a new window into disease and fuel the discovery of new therapeutics.
What are organoids?
Organoids refer to in vitro, 3D cell culture models involving multiple cell types, which self-organize to form a structure that mimics some aspect of an organ or tissue.2 Organoids can be generated from a range of cell types, including cells from normal tissues, malignant tumors, or cell lines, as well as primary stem cells, embryonic stem cells and induced pluripotent stem cells.1,3 Various combinations of growth factors, nutrients and extracellular matrix gels are used to create an environment conducive to self-organization, through cell sorting and spatially restricted lineage commitment.
Organoids used to pursue a more personalized approach to medicine
To address the issue of treatments working well for some patients, but not for others, there has been a move towards pursuing a more personalized approach to medicine – particularly for cancer research. Subsequently, approaches to the development of cancer therapeutics have included drugs targeted at specific mutations; for instance, EGFR and PIK3CA-targeted drugs.4,5 Unfortunately, however, these targeted drugs are not always effective in treating the tumor with the specific mutation, highlighting a knowledge gap that exists in understanding tumor responses.6
Patient-derived organoids (PDOs) have the potential to make personalized medicine significantly more successful, by serving as predictors for individualized tumor treatment responses. Partly, this is because of their convenient development timeline; personalized organoids can be grown within weeks from the time of biopsy, providing a way forward for precision medicine.7 Ovarian cancer PDOs, for example, have shown promise as important tools for clinical decision making; 36 whole-genome characterized PDOs from 23 patients were studied, and organoid responses to chemotherapeutics were compared with those of the patients. Organoids were subject to a range of treatments, including drugs that would not be expected to be effective for the tumor type (based on whole-genome sequencing data).8 Importantly, clinical response scores and PDO drug responses to a combination treatment were correlated, and a high responsiveness to at least one tested drug was identified. PDO subtypes can also be genetically manipulated, allowing researchers to probe the effect of individual genes and entire gene cassettes on other gene expression patterns, functions and interactions, as well as drug effects across a greater variety of disease states and genetic environments.9,10
Organoid Culture Handbook
While methods for generating organoids are still evolving, presently they are providing exciting and more accurate systems that are advancing our understanding of basic organ biology and tissue regeneration. Download this handbook to learn more about optimizing organoid culture conditions, tissue specific organoids and troubleshooting recommendations for culture.
View Handbook
Tumor heterogeneity remains one of the biggest challenges for cancer treatment. As a result of this heterogeneity, PDOs derived from different locations within the same tumor show differential responses. 8 With this in mind, one might wonder how to go about defining an "acceptable" level of predictivity. For Else Driehuis, researcher at the Clevers group at Hubrecht Institute and clinical molecular biologist in pathology in training at the University Medical Center Utrecht, the answer is straightforward: "I believe a reasonable measure is quite simple actually: it should perform better than what we have now. Simply, we can show that for a particular patient subset, for a particular drug, we can do better than the current selection criteria. That criteria may simply be a tumor type and stage in the clinic. Let's say all patients with disease X in stage Y get radiotherapy as the standard of care. 40% of them will benefit, the others don't. If, based on organoid screens we can get that number up, then implementing the use of organoids should be worth it."
For Driehuis and her colleagues, this goal has driven the development of a wide range of organoids, including pancreatic cancer organoids11-13 and oral mucosal organoids as potential platforms for personalized cancer therapy.14 The drive to implement organoids in healthcare is also supplemented with practical considerations: "However, we should weigh the benefits against potential downsides such as costs and treatment delays, etc – they are important aspects to consider," says Driehuis. Other groups have suggested that the issue of heterogeneity could also be mitigated somewhat in clinical settings by developing multiple organoids from different locations within the tumor. 8 In this way, cancer subtypes can be analyzed side-by-side for a comparison of drug response.
"In another example," adds Driehuis, "the treatment of patients with metastasized colorectal cancer with EGFR-targeting antibodies is nowadays only allowed if no mutations are identified in downstream genes such as KRAS. Still, amongst that group of patients that get the drug, we see quite variable response rates. If we can improve that with organoid screens, should we not ask ourselves if that should be the standard instead of genetic screening?"
The implementation of organoids will require usability, explains Driehuis: "If organoid screens are to be implemented in the clinic, they need to work in a routine diagnostic setting. If we can get those challenges manageable though, patients that will not benefit can then perhaps receive another treatment, or at the very least not be harmed by the side-effects of these treatments."
Automating Your 3D Cell Cultures
The use of organoids, self-organized three-dimensional (3D) assemblies of cells, as research tools has become more common due to their ability to better recapitulate human disease compared to more traditional models. Download this eBook to discover key challenges and advantages to using 3D cultures in a high-throughput setting and how to automate the handling of organoids.
Organoids serving as a window to viral mechanisms
"For infectious diseases, that's a much narrower field. There are really only a few infectious diseases that have been modeled in organoids," says Jürgen Knoblich, scientific director at the Institute of Molecular Biotechnology, Austrian Academy of Sciences. "Most is still in a research-phase. But organoids are playing a major role now in the SARS-CoV-2 epidemic." Indeed, organoids are being used to help unravel the mechanisms of SARS-CoV-2 infection. In May 2020 – only months after the pandemic began – SARS-CoV-2 was shown to infect human kidney organoids, resulting in infectious viral progeny.15 Their findings lay a foundation for exploring multi-organ dysfunction in patients with COVID-19. Organoids are also conducive to high-throughput drug screening for SARS-CoV-2, as shown through the use of lung organoid models derived from human pluripotent stem cells.16 Organoids can also be used to compare the susceptibility of different species to a virus, which could be useful for assessing the infectivity of emerging flu viruses in humans.17
As discussed in an aptly named review article "COVID-19: organoids go viral", organoids are becoming increasingly popular for infectious disease studies. 16 "The general reason for that," explains Knoblich, "is because many pathogens are very host-specific, meaning that the traditional drug development pipeline, which often involves animal models, does not work so well – or only works if you involve primates. And of course, nobody wants to do that." Knoblich's own career in organoid work has revolved around developing cerebral organoids for modeling microcephaly, which has had major implications for modeling the Zika virus.18 Organoids were used to show that the Zika virus can cause microcephaly, which helped the World Health Organization class the situation as a global pandemic.
More recently, Knoblich and colleagues extended these findings, whereby they uncovered key differences in encephaly-inducing mechanisms caused by the Zika virus, versus those of the herpes simplex virus.18 "We found that although, medically, both viruses have the same effect – they cause microcephaly – the actual cellular mechanism is fundamentally different. Zika viruses invade the cell and causes them to die. Herpes simplex viruses also invades the cells, but changes their shape. And so, if you wanted to treat this, you would have to use fundamentally different approaches."
One key finding was that both viruses fail to potently induce an important pathway: the type I interferon system. "Normally, a cell will detect the virus, and start the interferon response. It will start to reduce its own production of proteins, so that the virus cannot hijack that, and it will start to degrade everything in the cell that it doesn't like, and it will stop dividing, and go into defense mode." This process, which relies on intricate and rapid machinery, was observed in real time in the organoids. However, the fetal brain organoids were different, says Knoblich: "Very few cells showed this response, and it was delayed. The brain of a human fetus is not sufficiently protected against viruses. We reasoned that the final outcome of the innate immune response is the production of interferons, and so we applied interferons to the organoids." Organoid defects could be rescued with the application of interferons, and interestingly, different subtypes of interferons were required (interferon-ß for Zika virus, interferon-α2 for the herpes simplex virus).18 These findings reveal important differences between the viruses that have not been observed in 2D cultures.
Organoids for Disease Modeling and In Vitro Drug Screening
While the complexity of organoids remains challenging, technological advances are enabling organoids to be developed and monitored in an automated fashion, so that they can be exploited in high-throughput drug screening assays. Download this app note to discover how automated imaging and analysis can increase throughput and quantitative assessment of phenotypic changes.
Download App Note
Sponsored Conten
Working towards implementing organoids in healthcare
Organoids are expected to play a major role in the future of healthcare; they have the potential to improve personalized medicine and serve as key platforms for critical studies of infectious disease and many other disciplines. For organoids to fulfil their potential across a range of research areas, however, there is a need for greater standardization, explains Driehuis: "We need to make screening quick, reproducible, easy and feasible for implementation in healthcare. That's the challenge ahead I believe, and we aren't there yet. It's quite a big challenge actually, because first of all, we're dealing with living cells – so the variability introduced by different technicians and conditions is likely to have more of an effect than in DNA library preparation performed prior to DNA sequencing, for example."
Other challenges are specific to studies of pathogenic viruses, such as required safety levels complicating the use of robotics in high-throughput drug screens.19 Also, not all infectious diseases are suited to organoid studies, explains Knoblich: "We studied another virus that's not in the paper, a cytomegalovirus which is actually a much bigger health problem than the Zika virus. With the cytomegalovirus, we could recapitulate the pathology, but not the microcephaly. It just takes too long; it takes months and months for the virus to spread in the organoid. Experimentally, it's just a nightmare, as it's logistically very difficult. So that's why we settled on the herpes simplex virus; it's very aggressive and within a few days, the whole organoid is destroyed."
Looking ahead, the application of genetic engineering is likely to open many doors; for instance, by enabling manipulations of specific signaling pathways in cancer, and the identification of infected cells through the use of fluorescent reporters of different genes. 19,20 Improving the faithful representation of certain tissues remains a priority across the board, such as finding ways to develop more complex co-cultures that include immune cells. PDOs, on the other hand, have their own challenges, says Driehuis: "If you take a piece of tumor, it doesn't only contain tumor cells, but also immune cells, connective tissue and perhaps even tumor-adjacent healthy tissue. We need to figure out a way to look for the effect on the tumor cells only. I believe potentially imaging and artificial intelligence-driven algorithms can help us out there."
Imaging Organoids With Light-Sheet Fluorescence Microscopy
Studying tissue and organ biology is challenging, particularly in mammals, given sample accessibility and ethical concerns. However, the use of organoids alleviates these challenges, supporting researchers in exploring questions that previously could not have been investigated without them. Download this app note to discover how light-sheet fluorescence microscopy allows researchers to view whole organoids and cellular structures.
1. Simian M, Bissell MJ. Organoids: A historical perspective of thinking in three dimensions. J Cell Biol. 2016;216(1):31-40. doi: 10.1083/jcb.201610056
2. Lancaster MA, Knoblich JA. Organogenesis in a dish: Modeling development and disease using organoid technologies. Science. 2014;345(6194):1247125-1247125. doi: 10.1126/science.1247125
3. Shamir ER, Ewald AJ. Three-dimensional organotypic culture: experimental models of mammalian biology and disease. Nat Rev Mol Cell Biol. 2014;15(10):647-664. doi: 10.1038/nrm3873
4. Sukrithan V, Deng L, Barbaro A, Cheng H. Emerging drugs for EGFR-mutated non-small cell lung cancer. Expert Opin Emerg Dr. 2018;24(1):5-16. doi: 10.1080/14728214.2018.1558203
5. DiGrande S. FDA Approves first breast cancer drug to target PIK3CA mutation plus companion diagnostic test. AJMC. https://www.ajmc.com/view/fda-approves-first-breast-cancer-drug-to-target-pik3ca-mutation-plus-companion-diagnostic-test. Published May 29, 2019. Accessed August 26, 2021.
6. Aboulkheyr Es H, Montazeri L, Aref AR, Vosough M, Baharvand H. Personalized cancer medicine: an organoid approach. Trends Biotechnol. 2018;36(4):358-371. doi: 10.1016/j.tibtech.2017.12.005
7. Clevers H. Modeling development and disease with organoids. Cell. 2016;165(7):1586-1597. doi: 10.1016/j.cell.2016.05.082
8. Witte CJ de, Valle-Inclan JE, Hami N, et al. Patient-derived ovarian cancer organoids mimic clinical response and exhibit heterogeneous inter- and intrapatient drug responses. Cell Rep. 2020;31(11). doi: 10.1016/j.celrep.2020.107762
9. Monteil V, Kwon H, Prado P, et al. Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2. Cell. 2020;141(4). doi: 10.1016/j.cell.2020.04.004
10. Driehuis E, Clevers H. CRISPR/Cas 9 genome editing and its applications in organoids. Am J Physiol-Gastrointest Liver Physiol. 2017;312(3):G257-G265. doi: 10.1152/ajpgi.00410.2016
11. Driehuis E, van Hoeck A, Moore K, et al. Pancreatic cancer organoids recapitulate disease and allow personalized drug screening. PNAS. 2019;116(52):26580-26590. doi: 10.1073/pnas.1911273116
12. Driehuis E, Kretzschmar K, Clevers H. Establishment of patient-derived cancer organoids for drug-screening applications. Nat Protoc. 2020;15(10):3380-3409. doi: 10.1038/s41596-020-0379-4
13. Tiriac H, Belleau P, Engle DD, et al. Organoid profiling identifies common responders to chemotherapy in pancreatic cancer. Cancer Discov. 2018;8(9):1112-1129. doi: 10.1158/2159-8290.CD-18-0349
14. Driehuis E, Kolders S, Spelier S, et al. Oral mucosal organoids as a potential platform for personalized cancer therapy. Cancer Discov. 2019;9(7):852-871. doi: 10.1158/2159-8290.CD-18-1522
15. Han Y, Duan X, Yang L, et al. Identification of SARS-CoV-2 inhibitors using lung and colonic organoids. Nature. 2021;589(7841):270-275. doi: 10.1038/s41586-020-2901-9
16. Clevers H. COVID-19: Organoids go viral. Nat Rev Mol Cell Biol. 2020;21(7):355-356. doi: 10.1038/s41580-020-0258-4
17. Lancaster MA, Renner M, Martin C-A, et al. Cerebral organoids model human brain development and microcephaly. Nature. 2013;501(7467):373-379. doi: 10.1038/nature12517
18. Krenn V, Bosone C, Burkard TR, et al. Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly. Cell Stem Cell. 2021;28(8):1362-1379.e7. doi: 10.1016/j.stem.2021.03.004
19. Geurts MH, van der Vaart J, Beumer J, Clevers H. The organoid platform: promises and challenges as tools in the fight against COVID-19. Stem Cell Rep. 2021;16(3):412-418. doi: 10.1016/j.stemcr.2020.11.009
20. Hofer M, Lutolf MP. Engineering organoids. Nat Rev Mater. 2021;6. doi: 10.1038/s41578-021-00279-y
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Lab of the Future
The COVID-19 Pandemic
Advanced Cell Models
CRISPR and Genome Editing
Anticancer Therapies
High-Throughput Screening
Drug Kinetics
Screening Strategies in Drug Discovery
Spatial Biology
Infectious Disease Diagnostics
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New Approaches for Cancer Therapies: Targeting the DNA Damage Response
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Q: Swift 5. Display array from the 2nd tableview cell ( 2nd indexpath.row ) I have a tableview with 2 prototype cells that are 3 rows. The 1st prototype cell just has a view. The 2nd prototype cell has a button.
The 1st prototype cell is just 1 row which is also the first indexpath.row
The 2nd prototype cell has 2 rows. ( 2nd and 3rd indexpath.row )
I want to merge my model ( array ) with the 2nd and 3rd rows. But the app crashes and said out of range.
Tableview class
let modelArray = [phone, remote]

func tableView(_ tableView: UITableView, numberOfRowsInSection section: Int) -> Int {
return 1 + modelArray.count
}

func tableView(_ tableView: UITableView, cellForRowAt indexPath: IndexPath) ->
UITableViewCell {
if indexPath.row < 1 {
let cell = tableView.dequeueReusableCell(withIdentifier: "CELL1", for:
indexPath) as! CELL1
cell.view.backgroundColor = .red
return cell
}
let cell2 = tableView.dequeueReusableCell(withIdentifier: "CELL2", for: indexPath)
CELL2

This is where I am getting the out of range error. ( I tried it without the + 1 as well )
cell2.configure(title: modelArray[indexpath.row + 1])
return cell2
}

CELL2 class
@IBOutlet weak var buttonName: UIButton!
private var title: String = ""

func configure(title: String) {
self.title = title
buttonName.setTitle(title, for: .normal)
}

A: Please look at the logic:  cellForRow is called three times (1 + 2), but there is no item at index 3 in the array (nor at index 2 without +1).
According to the code the cell at indexPath.row == 1 is supposed to display the first item in the array (index 0) and the cell at indexPath.row == 2 the second item (index 1).
So you have to subtract 1
cell2.configure(title: modelArray[indexpath.row - 1])

A: because your modelArray have only 2 element and you are trying to get 3rd element value.
let's suppose when indexPath is 0 then tableview renders the CELL1 and when indexPath is incremented, we can say it when indexPath is 1 then your getting the value from your modelArray like below :
cell2.configure(title: modelArray[indexpath.row + 1])

which is getting the value modelArray[1+1] that turns in modelArray[2] but modelArray doesn't contains modelArray[2], it has only 0 and 1 element.
try with by subtracting 1 from current indexPath.
cell2.configure(title: modelArray[indexpath.row - 1])


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Bord Iascaigh Mhara Launches New R&D Fund
/ 10th October 2017 /
Nick Mulcahy
Bord Iascaigh Mhara has launched a new Research and Development fund to support innovation in the seafood sector and help grow the industry in line with stated government targets.
The funding was announced at WEFTA, the West European Fish Technologists Association's annual conference taking place in the Aviva Stadium from October 9 to 12.
With sales valued at €940m and representing 5% of total food and beverage exports, Ireland's seafood sector has been ear-marked by government as a key area for growth and investment.
BIM CEO Jim O'Toole commented: "Through the launch of the new research and development scheme for seafood producers and our facilitation of access to research and development insights for seafood companies, BIM is addressing the gap between translating research into commercial products."
Marine minister Michael Creed added: "This fund will continue to support the seafood sector into 2018 and beyond and will be crucial to helping the industry realise its potential."
Photo: Michael Creed (left) with Jim O'Toole. (Pic: Jason Clarke)
Inclusio to add 80 jobs on the back of €6m investment
Venture capital investment down 38% as investors become cautious
PlasmaBound ties down investment from BVP


Presentation Description: The presentation will provide insight into current global trends in private label with a particular focus on Western Europe. Euromonitor International will also be discussing private label within particular countries and categories. Potential areas for future growth will also be explored.


wikiHow is a "wiki," similar to Wikipedia, which means that many of our articles are co-written by multiple authors. To create this article, 29 people, some anonymous, worked to edit and improve it over time. Together, they cited 9 references.
Available year round, portable, sweet and creamy, bananas are a convenient way to add key nutrients to your diet. Bananas are high in vitamins, potassium, soluble fiber and protease inhibitors, which help remove stomach bacteria. Studies have found that regularly eating bananas helps maintain heart function, blood pressure levels, bone density, vision, digestion and kidney health. Buy bananas fresh and store them for future use.
Green bananas are not ripe yet. Buy green bananas for maximum storage life without freezing. Choose firm fruit without dark spots or abrasions on the peel.
Ripe bananas have turned their adult color. Most bananas are yellow when ripe, but some varieties are brown or red. The more the banana's adult color appears on the peel, the riper it is.
Brown-spotted bananas are the sweetest. As the small brown spots grow on the peel, the fruit inside ripens even further. When the peel shows more brown or black than yellow, the fruit is over-ripe.
Avoid bananas that have a gray tint and look dull in color. This is a sign that the bananas were refrigerated, which interferes with proper ripening.
Remove bananas from plastic produce bags as soon as you get them home. Never store bananas in plastic bags, which hold too much moisture and could cause the fruit to rot.
There is an alternative theory. The bananas may remain fresh longer inside the bag; take one out and leave the rest in the bag to test this. If the one that is removed ripens faster, then the bag may prove capable of retaining freshness. However, this may depend on the humidity and heat levels in the room where you're storing the bananas.
Store green bananas at room temperature. Refrigerating or freezing bananas before they ripen prevents the fruit from being able to properly ripen even after brought back to room temperature.
Put green bananas into a brown paper bag to speed up the ripening process. Add an apple or a tomato to the bag to ripen the bananas in less than 1 day.
Another way to speed up the ripening process is to place the bananas near other ripe fruit in a bowl, such as other ripe bananas.
Leave yellow-green ripening bananas exposed to air at room temperature for a few days. Be patient. Though it's true that the warmer the room, the sooner they will ripen, you should avoid placing the bananas in direct sunlight.
Hang the bananas on a banana tree. If you're a true banana lover, then a banana tree is a great investment. You can find free-standing banana trees that you can place on your countertop, as well as mountable banana hangers. Banana trees and hangers allow air to circulate and avoid "resting bruises" on the fruit.
Keep ripe bananas at room temperature if you will be eating them within a few days. Eat or refrigerate the bananas as spots develop on the skin and before they are overripe.
Keep sliced bananas fresh. If you've sliced a banana, whether it's to put it in the fridge or to make a delicious fruit salad, you should cover the slices in a bit of lemon juice, pineapple juice, or vinegar, all of which will keep it fresher for longer.
Pull the bananas apart from the bunch. If your bananas are already pretty ripe, then you can keep them fresh and yellow for longer by pulling each banana away from the bunch. This will keep each banana fresher for longer.
Store the ripe bananas with unripe fruit. Take an unripe pear or avocado and place it near the bananas, and it will slow down the ripening process of the bananas, while ripening faster itself. It's a win-win situation!
Wrap the stems of the bananas in plastic wrap. This will prevent ethylene gas, which is produced naturally during the ripening process, from reaching other parts of the fruit and making it ripen too fast. You can even place some tape over the plastic wrap for some extra security. Every time you remove a banana from the bunch, rewrap it carefully. Alternately, you can just separate the bananas from the bunch and then wrap the stem of each one individually. This takes a bit of love, but it's worth it!
Put the bananas in the produce drawer of your refrigerator after they are fully ripe. Refrigeration slows the ripening process considerably, but does not stop it. The peel will continue to turn brown, but the fruit will stay fresh and firm for 1 to 2 weeks. According to Dole Bananas, storing ripe bananas in the refrigerator will preserve their delicious taste for longer, even though their peels may turn black.
Peel the bananas before freezing them. Put as many as will fit into a zipper storage bag or plastic container and store in the freezer. Note: Freezing bananas in their peel will make it impossible to peel them if frozen. And once they thaw, they turn into a goopy mess. Add frozen, peeled bananas to smoothies.
Store bananas in the freezer for several months. When thawed, you can use the bananas to bake and cook, as well as in fruit sauces and smoothies. You can also drizzle them with just a bit of lemon juice to keep them from turning brown.
Peel bananas and cut them into chunks or mash them before freezing.
Portion the banana into the amounts you need to make a recipe.
Put portioned bananas into zipper freezer bags or plastic containers and store them in the freezer.
Make banana bread with overripe bananas. Banana bread is a delicious treat that is designed to be made with overripe bananas. If it's too late for you to store them and eat them enjoyably, then it may be time to make this delicious treat. After all, you don't really want to waste what was once a tasty bunch of bananas, do you? All you need is a few simple ingredients, which include bananas, nuts, flour, eggs, butter, and cinnamon.
I took a baking class this week and the teacher said always separate bananas do not keep them in a bunch or together for slowing down ripening. I hang mine on a banana hanging tree that holds them together. Should I put them in a bowl separated instead?
Once the bananas have ripened, separating them from the bunch is a good idea to prevent them from ripening any further in a speedy manner. However, this is space consuming and isn't really something most people have the time and space for doing. If you and your family/household members eat bananas quickly and regularly, it shouldn't really matter that the ripe bananas remain in a bunch, as long as they're eaten soon after ripening. Any bananas that ripen too quickly can be used in muffins, cakes, and other baked goods.
Can I store bananas with other fruits in the same bowl, or should I keep them separate?
You should store bananas separately. If you store them with other fruit, the other fruit may ripen quicker and go bad before you can eat them.
I defrosted bananas and peeled them ready to bake with them. I left them in a sealed container in the refrigerator for 2 weeks. Are they still safe to bake with?
In this case, the answer is that a few weeks is probably a little too long. Keeping refrigerated and using within a few days is recommended, but after that time, the mashed flesh may deteriorate or even have bacterial growth. Look at the color and texture and smell the mash, to determine how the thawed bananas seem to you. Anything that appears bad is a reason to discard the bananas.
Is it okay to store bananas in the refrigerator?
It's not recommended but equally, it's not clear cut! The reason for not recommending storage of bananas in the fridge is that the skin will blacken (hence, they look awful) and they stop ripening because the ripening enzymes break down below 4ºC. That said, if the bananas are already as ripe as you'd like them to be and you don't mind the skin being blackened, then you can store them in the refrigerator. Some people actually prefer unripe banana flesh, so are not bothered that it won't ripen any further. The optimal storage temperature for bananas is around 10ºC.
Do fruit flies come from bananas?
Fruit flies are often attracted to bananas.
How do I store half of a banana?
If you plan to use it in the next couple of days, rinse well and store it in a Ziplock bag. Otherwise, you should freeze it.
Any recommendations for storing bananas at room temperature, without making them subject to fruit flies?
I store bananas in the microwave, which completely eliminated the fruit-fly problem.
How do you keep mashed bananas from turning brown?
If you add lemon juice, they will stay nice and yellow and not turn brown. The same thing works with apples.
What is the best way to store ripe bananas if I am not serving them for 4 days and would like to keep them yellow and beautiful?
If you are only concerned about the appearance of the light yellow color of the edible portion of the banana, you can store them in the fridge. The skins, however, will turn black using this method. I'm not aware of any method that would also preserve the yellow color of the skin.
Do bananas on banana trees ripen faster than if left on the counter in a bunch?
Bananas left to ripen on trees split and become floury and unpalatable. This is one fruit that must be removed prior to ripening and allowed to ripen off the tree, so as to avoid the undesirable ripening qualities on the tree. Bananas are much better ripening in a bunch on your counter.
How long can I store peeled bananas in the freezer compartment?
How do I store bananas so that they don't ripen all at once?
Can I store bananas in foil or paper instead of plastic wrap?
What is the best way to keep bananas fresh?
How do I keep bananas from getting overripe before using them, since it will be four days before I use them for banana pudding?
Bananas left at room temperature may draw fruit flies. Store the bananas in a sealed paper bag or in the refrigerator if fruit flies are a problem.
To store bananas, start by separating them so they're no longer bunched together. Then, wrap the stem of each banana with plastic wrap, which will slow down the ripening process. After that, put the bananas in a drawer in your fridge and store them there for 1-2 weeks. To make the bananas last even longer, put an unripe fruit like an avocado or pear in with the bananas so the bananas don't ripen as quickly.
"Answered all my questions on storing and using bananas."
"Excellent article, full of very useful tips."
"It did help me in storing my bananas."


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Old Time Country Community Radio Show
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Happy Fans Stay Up Late to Welcome Home Victorious Lady Tigers (VIEW VIDEO HERE)
By: Dwayne Page
The DCHS Lady Tigers, coaches, and cheerleaders returned home to a hero's welcome late Saturday night as happy fans gathered at the high school gym to celebrate their team's sub-state victory over McMinn Central 44 to 42 on the road at Englewood.
The team is part of the elite eight in the Class AA State Tournament and will play on Wednesday at MTSU in Murfreesboro at 1:15 p.m. against 26-7 Marshall County. It's the first state tournament appearance by a DCHS girls team since 1965.
IMG_4663 from dwayne page on Vimeo.
The Lady Tiger's charter bus arrived at the high school around 11 p.m. Saturday and was escorted through town by Sheriff Patrick Ray, Smithville Police Chief Mark Collins, and the Smithville and DeKalb Fire Departments, along with Darrell Gill of Gill Automotive, an avid DCHS athletics supporter, who sounded his train horn along the way in celebration of the Lady Tigers' win.
After stepping off the bus, the team assembled inside the gym to celebrate with family and fans and Coach Danny Fish made some brief remarks, thanking them for their support.
"I can't tell you how proud I am of this group. We have a lot of special individuals in this group. Teams are made up of a lot of good players but it's those individuals that can sacrifice themselves that makes the best teams. I love athletics because it teaches so many life lessons. Not everything is always going to go your way in life. The ball is not going to go in the hole all the time. You're going to make mistakes but it's not that which defines you it's the moments after that which do," said Coach Fish.
"There are many faces here who have contributed to what we have here tonight and in these girl's lives to make them a better person and basketball player. I thank you for that because it definitely makes my job easier. I thank you parents for your support. This is a great moment. We would like for you (fans) to come out and support us on Wednesday. We will know what time and who we play (Sunday) but whoever we play Cinderella (Lady Tigers) still has the shoe on," added Coach Fish.
Lady Tigers State Tournament Bound!
The DCHS Lady Tigers are bound for the TSSAA Class AA State Tournament after defeating the McMinn Central Chargerettes 44 to 42 at Englewood Saturday night in the sub-state or sectionals.
It's the first trip to the state tournament for a DCHS Lady Tiger basketball team since 1965.
DeKalb County, one of eight teams in the Class AA Girls State Tournament, will play on Wednesday, March 6 at MTSU in Murfreesboro either at 10 a.m., 11:30 a.m., 1:15 p.m., or at 2:45 p.m. The exact time and opponent have not yet been determined. WJLE plans LIVE coverage
(The DCHS Lady Tigers, coaches, and cheerleaders got a rousing send-off Saturday afternoon as they departed for the sub-state game at McMinn Central in Englewood)
The game was close throughout as the Lady Tigers led 10 to 7 after the 1st period but trailed 19 to 17 at halftime. DeKalb County held a 32 to 30 edge after the 3rd period and went on to win 44 to 42.
Lydia Brown scored 16, Kadee Ferrell 15, Maddison Parsley 7, and Emme Colwell 6.
The Lady Tigers improve to 23-11 on the season. McMinn Central closes out their season at 20-14.
Members of the 1964-65 DeKalb County team included Betty Carol Fite (who is a sister to Lydia Brown's grandmother), Brenda Cripps, Elaine Harvey, Judy Young, Wanda Williams, Sherry Frazier, Kay Davis, Betty Evins (Kadee Ferrell's grandmother), and Katherine Wright among others. Harold Luna was the coach (Luna is Lady Tiger Coach Danny Fish's great uncle)
In the 1965 State Tournament the DeKalb County Tigerettes (as they were known then) defeated Walland 40 to 38 and Hillsboro 61 to 42 but lost to Sevier County 37 to 34 and to Bradley Central 49 to 34.
According to TSSAA, DeKalb County also made state tournament appearances in girls basketball in 1959, 1928, and 1926 and finished as the state champion runner-up in 1959.
Fans Cheer Lady Tigers As They Leave for Sub-State Game (VIEW VIDEOS HERE)
The DCHS Lady Tigers, coaches, and cheerleaders got a rousing send-off Saturday afternoon as they departed for the sub-state game at McMinn Central in Englewood tonight.
Excited family, friends, and fans gathered at the high school and cheered members of the program who filed passed them before boarding a charter bus for the trip. There was also a balloon release and Darrell Gill was on hand to sound his train horn as he does during DCHS football games The Smithville Police and Sheriff's Departments including Sheriff Patrick Ray accompanied the bus in a motorcade from the high school down West Broad before turning onto Cookeville Highway. As the bus left the city limits, Sheriff Ray continued the escort to Interstate 40.
The Lady Tigers (22-11) are enroute to meet the McMinn Central Lady Chargers (20-13). Tip-off is at 7:00 p.m. (eastern time) which is 6:00 p.m. Smithville time. The winner will advance to the state tournament next week. WJLE will have LIVE coverage of tonight's game with the Voice of the Lady Tigers John Pryor. Our pre-game show, Tiger Talk will air at 5:40 p.m. featuring Lady Tiger Coach Danny Fish and Lady Tiger seniors Lydia Brown, Maddison Parsley, and Joni Robinson.
Fans making the trip can view a google map on the WJLE website sports page for directions.
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Jewish World Review Feb. 18, 2011/ 14 Adar I, 5771
News reporters --- or Narrative Shapers?
http://www.JewishWorldReview.com | A funny thing happened on the way to the glorious democracy ostensibly emerging in Egypt. CBS reporter Lara Logan, "covering the jubilation" as CBS put it, was surrounded by a mob of men screaming, "Jew, Jew!" who beat and sexually assaulted her. She is currently recovering in a U.S. hospital from injuries described as "serious." Despite the fact that the incident occurred last Friday, CBS sat on the story until it became apparent that other members of the media had gotten wind of it. Why? The bet here is that this incident interferes with the mainstream media-established narrative regarding the true nature of some "freedom-loving" Egyptians. People yearning for democracy aren't supposed to be anti-Semitic thugs or sexual predators as well. Thus, a genuine news item became an "un-story."
Perhaps the mainstream media news organizations should no longer be called news organizations. Perhaps a better name would be narrative shapers. If there is one certainty that exists today, it is the idea that truth has become a sidebar to political agendas. CBS and others operate one hundred and eighty degrees out of phase with the late Daniel Patrick Moynihan's immortal contention that "everyone is entitled to his own opinion, but not his own facts."
Here is an unpleasant fact: Islam treats women and non-believers like second-class citizens, aka dhimmis, under the best of circumstances. Under the worst of circumstances, dhimmitude can literally be deadly.
How deadly? Another "unpleasant" reality being kept under the radar by our mainstream narrative shapers involves a 14-year old Bangaladeshi girl known as Mossamet Hena or Hena Begum. Hena was raped by her 40-year old married cousin. For her "crime," she was first beaten by family members. After that, a village arbitration committee comprised of elders and clerics using Sharia Law as their guide, issued a fatwa calling for the girl to receive 100 lashes with a whip. After 80 blows, Hena fell unconscious and died in a hospital six days later. The village also imposed a $700 fine on her family in a country where the average annual income is $520.
Who covered the story? Other than the blogosphere, my research revealed two traditional news sources: the BBC and USA Today. But USA Today didn't do its own story--it cited a Bangaladesh newspaper, the Daily Star, as its source. Why would such a story remain under the radar? National Review's Andrew C. McCarthy, who mentioned this atrocity in a recent column, explains:
"Under sharia, rape cannot be proved absent the testimony of four witnesses. Rapists tend not to bring witnesses along for their attacks. In any event, moreover, sharia values a woman's testimony as only half that of a man, so the deck is stacked and rape cannot be proved in most cases. Yet that hardly means the report of rape is of no consequence. Unable to establish that she'd been forcibly violated, the teenager became in the eyes of the sharia court a woman who'd had sexual intercourse outside of marriage. Thus the draconian lashing sentence that became a death sentence."
Such clarity is utterly anathema to a mainstream media which has hitched its wagon to the multiculturalist star. It is a linkage so secure that a 14 year old girl first raped and then beaten to death is swept into obscurity, lest the true nature of Sharia Law be revealed in all its bloodthirsty excess. It is a linkage so secure that even the sexual mauling of one of its own is to be calculatingly suppressed, lest some of the actors in the current narrative of "jubilant Egyptian the democracy" be revealed as the tip of a less-than-jubilant, no-so-democratic iceberg.
Make no mistake: CBS only revealed the story when other news organizations got wind of it. At that point they decided to be "in front of the story" as they say in newsrooms. Despite that decision, CBS still attempted to rationalize it, according to an inside source who told the NY Post that "Logan was 'involved in the process' of deciding whether to make her attack public," implying that her permission was necessary in order to disseminate the story. That's nonsense, plain and simple.
What is really going on in the Middle East? Upheaval--of a largely undefined nature. Where is it leading? Despite mountains of "expert" analysis, one really knows, not even the participants themselves. The American news media? A pack of Walter Durantys with narratives as tailored as those the NY Times Pulitzer Prize-winning reporter spun about the great "democratic reformer" known as Josef Stalin. A group of narrators as practiced in the art of taqiyya, which is defined as lying to protect Islam, as the Islamists themselves.
And not just Islamists. In my entire career as a columnist, I can't recall a time when so many members of the Fourth Estate were so willing to run interference for a president and his administration. Can anyone remotely imagine CBS spiking the same story if George W. Bush were president? Lara Logan would have been the poster girl for "unrealistic expectations of democracy in Egypt." Bush would have been thoroughly excoriated for his idea that freedom is "G0d's gift to mankind," even as Barack Obama's water-carriers have been characterizing the events in Egypt as "one the great triumphs of the human spirit" (Thomas Friedman, NY Times), or "a massive eloquent validation of the moral force and power of non-violent civil disobedience" comparable to the "legacies of Mahatma Gandhi and Martin Luther King." (Clarence B. Jones, Huffington Post).
Tell it to Lara Logan, fellas.
I wish Ms. Logan a speedy recovery. I wish I could do the same for Hena Begum. If it were up to the far too many narrative shapers in the mainstream media, you wouldn't have heard a word about either one.
02/16/11: The Presidents Budget Proposal: An Obamination of Progressive Profligacy
02/14/11: Only Another 9/11 Will Alter the Illegal Immigration Status Quo
02/10/11: Is O'Reilly losing his touch or is he just irresponsible?
02/07/11: Tossing Britain Under the Bus
02/03/11: Starving the World In Order to Save It
01/31/11: Walking the Middle East Tightrope


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← A view of Providence in 1808
Providence riots, 1824, 1831 →
Save the Frick Music Room
The Frick Collection, 70th Street facade. (ny-architecture.com)
Boards of institutions always seem to want to do more for the institution than the institution needs. And whenever a board proposes to do something, it is normally more than is judicious, often a lot more – a unwitting attack on the values of the institution itself.
Exhibit One: The proposal to stuff more stuff into the Frick Collection, the house museum cum art gallery on Fifth Avenue in Manhattan. The board of the Frick has proposed more than a few abortive renovations of late and finally decided to push one of relative modesty by modernist Annabelle Selldorf. Even I supported the Selldorf plan when it was unveiled, because Selldorf's exterior revisions seemed to be at least minimally classical, not modernist as is invariably the expectation. It is important to show the public that new classical work of a high order can be done, and that beauty is not something lost to the past.
Such demonstrations are rare. My favorite is the 1990 classical addition to the 1904 John Carter Brown Library, on the Brown University campus in Providence. God, what a row that must have caused when first proposed! Its board deserves congratulations, as does the huge firm of Hartman-Cox, from Washington, D.C., which designed an addition slightly less rococo than the original, something virtually unheard of then. Beautiful!
Similar exterior changes were offered by Selldorf for the Frick, and approved last year by the city's Landmarks Preservation Commission. Unfortunately, in attempting to shoehorn new space into the building, Selldorf proposes to demolish the circular Music Room, designed by John Russell Pope in the 1930s, and the Reception Hall, designed by John Barrington Bayley in the 1970s. Both were additions to the original 1914 mansion of steel magnate Henry Clay Frick on Fifth Avenue, designed by Thomas Hastings, but were so well conceived that the luxuriant domesticity of the house was enhanced.
Critic Catesby Leigh, writing in City Journal, the quarterly of the Manhattan Institute, describes in "Degrading a Masterpiece" the complex give and take supposedly needed to accomplish the expansion that the Frick board desires:
The plans have some positive aspects. It will be wonderful for visitors to climb the original mansion's grand staircase to the second floor, where Pope converted family quarters into museum offices. These will now be used for the exhibition of small paintings, drawings, and works of decorative art. And the Frick has long emphasized its need for a larger auditorium, better conservation facilities, and better accommodations for school groups. But to degrade the existing house museum would be a terrible mistake.
Here Leigh, with his inimitable facility for painting architecture in words, describes why the Music Room must be saved:
Pope's Music Room—mainly used for film screenings and lectures but best known as a much-loved chamber music venue—opens off one side of the Garden Court by way of two handsome little lunette-shaped, wood-paneled vestibules that reconcile the court's rectangular plan with the Music Room's circular form. Such refined architectural sequences are one of the Frick's glories. Above the wainscot, the wall of the Music Room is covered in golden damask enriched with a leafy sylvan pattern. A floral rinceau runs along the frieze above. Elegant doorways are framed by Ionic pilasters. The flat ceiling extends from a cove, with ornamented ribs extending from the circular skylight's elaborately molded frame. This room would make an excellent special exhibition gallery, and in fact it was designed to serve as a gallery. It is an essential part of one of the most superbly orchestrated spatial ensembles America has to offer. Along with the rest of this ensemble, it should be left intact.
Leigh adds:
[Selldorf] and the Frick want to atone for the destruction of the Music Room and its vestibules by retaining the room's original doorways. But great architecture, in a room as in a building, is like a great painting or sculptural work, in which every form reinforces every other form in constituting a whole that is not only greater than the sum of its parts, but that casts a spell—precisely because of its formal consistency. Where's the magic in retaining beautiful doorways that simply point to the poverty of their new architectural setting? …
In informing the New York Times that she wanted her Frick renovation to "have its own identity," Selldorf gave the Pope-Bayley precedent the boot and demonstrated that she is the wrong architect for the job.
Soon the board will take its plans to the city's Board of Standards and Appeals, the last chance to pause before committing an unforgivable desecration. Let's hope that board will read Catesby Leigh's insightful assessment, which all viewers of this post should read in its entirety.
The Frick constitutes a single artistic entity that flows through Hastings, Pope and Bayley over six decades without a burp of aesthetic inconsistency. These sorts of architectural masterpieces are increasingly rare in New York, indeed in America. If the Frick's board wants to stuff more stuff into the Frick, let it buy another building nearby and park its ambitions there.
The Music Room in 1935. (frick.org)
Rendering of proposed Frick renovation, 70th Street facade. (Selldorf)
This entry was posted in Architecture, Preservation and tagged Annabelle Selldorf, Catesby Leigh, City Journal, Frick Collection, John Barrington Bayley, John Russell Pope, Manhattan Institute, New York, Thomas Hastings. Bookmark the permalink.
2 Responses to Save the Frick Music Room
Peter Van Erp says:
The Frick is falling to the same Edifice complex which has destroyed many institutions (See: the Cooper Union). It is my favorite museum in NYC.
I agree. John and I were at the Frick last spring for the Moroni exhibit, as well as a lecture on Tintoretto in the lovely auditorium. best, Philip


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Cabinet puts Section 377 in Supreme Court's hands
The Union Cabinet on Thursday, decided to ask Attorney General G E Vahanavati to assist the Supreme Court in arriving at an opinion on Delhi High Court's verdict to decriminalize consensual sex among consenting adults. Giving details of the Cabinet meeting to the media, Union Information and Broadcasting Minster Ambika Soni said the government would not oppose the Delhi High Court's order decriminalizing homosexuality. "The Attorney General would help the Supreme Court in arriving at an opinion on the Delhi High Court judgment," Soni said. On July 2 the Delhi High Court gave the verdict to decriminalize the homosexual activities, which was a criminal offence under Section 377 of the Indian Penal Code (IPC). Several people, including Yoga guru Baba Ramdev approached the apex court against the Delhi High Court's verdict. Legalizing gay sex would have a catastrophic effect on the society's moral fabric, said Ramdev in his petition. Earlier, on August 17, hearing the petition, the Supreme Court sought the opinion of the Union Cabinet on the matter. The Union Ministries of Home, Health and Family Welfare and Law had agreed that the judgment would not be challenged by the Government in the Supreme Court. Union Home Minister P Chidambaram, Health Minister Ghulam Nabi Azad and Law Minister M Veerappa Moily had held series of meetings to arrive at a conclusion on the issue.


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The assault on four doctors, allegedly by the relatives of a patient, who died at the K.R. Hospital a few days ago, has raised several questions. Geeta Avadhani, Dean and Director, Mysore Medical College and Research Institute, said most patients reach K.R. Hospital in critical condition.
Despite the doctors' best efforts, some people die owing to health complications. She said two or three attacks on doctors and paramedical staff had occurred in a year.
Complaints registered in the past with the police have not yielded the desired results. The existing laws as per the Karnataka Prohibition of Violence against Medicare Service Personnel and Damage to Property in Medicare Service Institutions Act, 2009 should be strictly implemented, she said. In most cases, attackers had been let off with light punishments. Though patients' relatives have the consent letter, assaults still occur which was demoralising, she added.
The K.R. Hospital, it appears, needs a 'surgery' as it faces a few problems. A good number of drunken attendants stay with patients or loiter around on the hospital premises in the nights, ready to pick up a fight with doctors on duty . Such incidents are preceded often by the choicest abuses on doctors. Imagine the plight of a woman doctor in that case, said a doctor who wished to remain anonymous. The hospital lacks toilets for the staff as the ones located in the duty rooms are used by all, including patients' attendants, security personnel and even dogs could be found sleeping sometimes, the doctor said.
Some of the security guards who are posted to the hospital through agencies are old and lacked the initiative to take control of complicated situations. There is an urgent need for improving the laboratory facilities in the hospital as prescriptions for tests and investigations in the night could not be carried out. About 1,000 patients visit the K.R. Hospital every day, mainly from the rural areas and from the poorer strata of society. On any given day there at about 600 to 700 patients admitted in different wards.
Dr. Avadhani stated that there was no dearth of medical officers at the hospital. Doctors get irritated when the kin of patients make mobile phone calls to MLAs and Ministers and hand over the phone to the doctors who are then forced to do the bidding of such VIPs. Concurring with the statements of Dr. Avadhani, Medical Superintendent B.G. Sagar said that assaults on doctors were occurring repeatedly and the authorities should ensure protection to them.
Dr. Avadhani said the police had agreed to post policemen at important sections such as medical emergency and casualty wards.


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Home • Youth & Education
Foyle Ambassadors
The Foyle Ambassadors programme, operated by the Loughs Agency and Co-operation Ireland in partnership with the Department for Foreign Affairs, has been designed to discover the social, economic and environmental importance of the River Foyle, from source to sea, while at the same time providing young people with opportunities to engage and build relationships across the city, region and political divide.
This is done through a range of adventure activities such as boating, surfing and canoeing; environmental projects such as cleans ups and personal development sessions.
Co-operation Ireland CEO Peter Sheridan said,Peter Sheridan, Chief Executive of Co-Operation Ireland said 'Co-operation Ireland are delighted to have been a partner in the Foyle Ambassador programme. Too often Lough Foyle is associated with the sadness of people taking their own lives or with the river environment being used for drug dealing or other criminality but today we now have almost 100 young people who see the lough as a place to explore its wildlife and the opportunity it provides for recreation and conservation.
"We want to pay tribute to the young people who graduated on this year's programme. We hope that they and the many young people who take part in future programmes will see lough Foyle as a resource that can bring economic benefits and many environmental and recreational opportunities. Lough Foyle is a place to be proud of."
Allan Bogle, Community Engagement Officer at Loughs Agency said "throughout the summer the young people truly became ambassadors of the Foyle recognising its importance as a natural resource. Ambassadors not only built lasting connections with the river they also developed lasting friendships with each other. The experiences they have gained will provide them with skills for life through fun, friendship and adventure."
Foyle Ambassadors programme has the potential to reach many more young people throughout the Foyle and Carlingford areas. Loughs Agency have set a target of having 1,000 Ambassadors and 2019 saw the commencement of the Carlingford Ambassador Programme. If you are interested in the programme, contact Allan Bogle at Loughs Agency for more information on 02871 342100.
Uniting Communities
CATCH Programme
Youth Network for Peace
North West Ministry of Youth Project
Amazing the Space
National Citizen Service in Northern Ireland
Cross Border Youth Leadership Project
Young Advocates
Entwined Histories
East Belfast Good Relations
YouthPact


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Dr Suzi Gage: "Podcasts are my saviour"
By Pod BibleSeptember 8, 2021
In each issue of the magazine, we ask a Podcast Disciple five questions about their love of podcasts and podcasting. For Issue #006 of the Pod Bible magazine we were joined by Dr Suzi Gage, from Say Why To Drugs! Why do you love podcasts? My work means a lot of travelling to conferences or to give guest lectures, so...
Daniel P. Carter: "An excuse to paint portraits of people I like"
By Pod BibleMay 27, 2021
In each issue of the magazine, we ask a Podcast Disciple five questions about their love of podcasts and podcasting. For Issue #004 of the Pod Bible magazine we were joined by Daniel P. Carter, from BBC Radio 1 and his own podcast Someone Who Isn't Me! Daniel, why do you love podcasts? Well most of the podcasts I listen...
Brett Goldstein: "I like the expansiveness of podcasts"
By Pod BibleApril 29, 2021
In each issue of the magazine, we ask a Podcast Disciple five questions about their love of podcasts and podcasting. For Issue #003 of the we're joined by Brett Goldstein from the wonderful Films To Be Buried With! Why do you love podcasts? I like to have the feeling of being with friends and listening to them chat but with...
Jamie Laing: "This is just the beginning of audio"
In every issue of the Pod Bible Magazine, we ask a Podcast Disciple five questions about their love of podcasts and podcasting. Our Podcast Disciple for Issue #010 was Made In Chelsea stalwart, and one half of the Private Parts podcast, Jamie Laing! Why do you love podcasts? I've always loved audio – as a kid I used to listen...
Kelechi Okafor: "There's a podcast for literally everything"
The Team at Pod Bible have been looking through the magazine back catalogue with more than a hint of nostalgia. With so many great articles and interviews, we thought it was time to share them on the website. In each issue we ask a Podcast Disciple five questions about their love of podcasts and podcasting. Our Podcast Disciple for Issue #008...
Helen Zaltzman: "no permission or commissioners required"
By Pod BibleMarch 23, 2021
The Team at Pod Bible have been looking through the magazine back catalogue with more than a hint of nostalgia. With so many great articles and interviews, we thought it was time to share them here on the website. The Point Of Entry article on The Allusionist last week reminded us of this amazing interview from Issue #002 where we asked...
Kate Thornton: "Eavesdropping on the way people talk"
By Pod BibleMarch 2, 2021
The Team at Pod Bible have been looking through the magazine back catalogue with more than a hint of nostalgia. With so many issues worth of great guest articles and interviews, we thought it was time to make our archive as accessible as possible and share them here on the website. In Issue #005 of Pod Bible Magazine, we asked...


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