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The FTC has awarded $30 million in compensation to the Career Education Corporation (CEC) for deceptive recruiting practices. The company obtained sales leads by misrepresenting its affiliation with the U.S. military and misleading students about the quality of its programs. The result of this practice was that many students enrolled in affected schools but did not receive the training they were promised. The company has agreed to stop collecting debts and reform its recruitment practices.
1 While the lawsuit seeks to recover lost profits, it also aims to protect students from future deception.
1.1 The Career Education Corp.
1.2 In addition to settling the lawsuit, the Career Education Corporation has agreed to cease all illegal recruitment and enrollment practices and to reimburse all students' debts.
1.2.1 The Career Education Corporation settlement only benefits borrowers who owe money to the company.
While the lawsuit seeks to recover lost profits, it also aims to protect students from future deception.
The case cites two recent cases where Career Education Corp. lied about the costs of tuition, including false advertising, and used emotional language. While the company denies any wrongdoing, it has agreed to provide new disclosures about their programs, phase out programs that do not allow students to take licensing exams, and provide a list of borrowers who attended certain of their New York programs from 2009 to 2012. These borrowers will be able to claim a portion of the settlement fund.
The lawsuit is similar to many other class action suits involving for-profit schools. Janet Blake, a former student of Sanford Brown College, filed a class-action lawsuit against Career Education Corporation and a subsidiary company, which subsequently removed the case to Circuit Court of the County of St. Louis. The plaintiffs allege that the defendants violated the Missouri Merchandising Practices Act by misrepresenting the replacement rate of student loans.
The Career Education Corp.
settlement claims that the organization lied to prospective students and regulators about the costs of their programs. By misleading prospective students, the company could boost enrollments and revenues. Several claims in the lawsuit allege that the company advertised job placement rates of 55 percent to 80 percent. In reality, the rate was closer to twenty-four percent. Despite these allegations, the lawsuit has not yet been resolved. The case continues to be litigated.
The company settled the case for $493 million and has agreed to reform its recruiting and enrollment practices. The company has also agreed to waive the debts of 179,529 students. In addition to the settlement, the CEC has agreed to provide new disclosures and cease collecting debts from these students. In addition, the company has agreed to phase out certain programs in New York that do not allow students to take the required licensing examinations. The suit also stipulates that the CEC must release a list of student graduates of certain New York programs from 2009 to 2012.
In addition to settling the lawsuit, the Career Education Corporation has agreed to cease all illegal recruitment and enrollment practices and to reimburse all students' debts.
The company has also agreed to provide a list of its students who have graduated from the school since 2009. The companies' settlement has resulted in almost $500 million in refunds for the victims. In addition, the case has made the Career Education Corporation commit to reforming its recruiting and enrollment practices.
The lawsuit alleges that the company failed to disclose the costs of its programs and the jobs of its graduates. In addition, the Career Education Corporation was unable to disclose the cost of its programs and lied to students about their employment prospects. A federal investigation led by Tom Miller's office found that the organization was knowingly charging students for courses it did not have accreditation. This practice prevented them from obtaining jobs in fields such as medical ultrasound.
The Career Education Corporation settlement only benefits borrowers who owe money to the company.
In addition, a large portion of the students who borrowed money from the company is not eligible for the settlement. In addition, the Career Education Corporation also lied to the government about the number of jobs they offered to their borrowers. This practice boosted the company's revenues and increased its enrollments, and it is now paying back those enrolled in its schools.
The Career Education Corporation settlement was a win-win situation for its students and its clients. The company settled in the suit with the state and was forced to provide new disclosures to its students. It has also agreed to phase out certain programs and hire an independent auditing company. This agreement will require the corporation to terminate the employees responsible for misleading practices. It also requires them to disclose their compensation and dismiss those who were behind them.
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Comparative Evaluation of Cotton Seed Meal and Sunflower Seed Meal in Urea Molasses Blocks Versus Commercial Concentrate as Supplement to Basal Ration of Wheat Straw with Stall-fed Buffalo Calves
I. H. Mirza, M. I. Anjum, A. G. Khan, A. Azim
Asian-Australasian Journal of Animal Sciences 2004;17(2): 193-198.
DOI: https://doi.org/10.5713/ajas.2004.193 Published online January 1, 2004.
Eighteen water buffalo calves of Nili-Ravi breed (about 15 months age and of 147 12 kg average body weight and mixed sex) were used with six animals on each treatment. All the animals were fed long wheat straw for ad libitum intake as the basal ration. Animals in group-I were supplemented with ad libitum amount of urea molasses block having cotton seed meal (CSMB) while the animals in group-II were supplemented with ad libitum urea molasses block containing sunflower seed meal (SFMB) and group III animals were supplemented with a fixed amount of commercial concentrate feed (CCF). The experiment lasted for a period of 80 days (April to June). Results revealed a significantly decreased total feed intake (wheat straw+supplements) in group-III (1,666 52 g/h/d) as compared to group I (2,299 194 g/h/d) and group-II (2,193 230 g/h/d). Average daily supplement intakes were 891 87; 666 104 and 593 0 grams per head in group I, II and III, respectively. Supplement intakes among groups were different (p<0.05). Average daily body weight gains (g/h) were 214 25, 174 23 and 183 24 for group I, II and III, respectively. Feed conversion ratio (FCR) was found to be 10.74 1.12, 12.60 0.88 and 9.90 1.33 grams for group No. I, II and III, respectively. The economic net benefit of live weight gain of calves were 7.63, 6.11 and 7.33 rupees/h/d for group No. I, II and III, respectively. Thus SFM can replace CSM and urea molasses blocks can replace commercial concentrates as supplement to basal ration of wheat straw
Keywords: Buffalo Calves; Urea-molasses Blocks; Cotton Seed Meal; Sunflower Seed Meal; Commercial Concentrate; Wheat Straw
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redpajama_set_name: RedPajamaCommonCrawl


text:
Looking Ahead to Widespread Rain on New Year's Eve, Snow North
The mountains and much of northern Maine has 3-6 inches of fresh powder in the forecast
By Denise Isaac
Published Dec 30, 2018 at 12:47 PM | Updated at 12:24 AM EST on Dec 31, 2018
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Rain Coming to Close Out the Year
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Early sun then clouds are expected for Monday.
(Published Monday, Dec. 31, 2018)
After a gloomy start to our Sunday due to a disturbance that moved through the region this morning and left flurries in some spots, expect to see the sun this afternoon with seasonable temperatures.
Highs will be in the mid to upper 30s in Southern New England while 20s to the north. Mostly clear skies tonight with lows in the teens and 20s.
Clouds return on Monday as our next area of low pressure moves in from the southwest, and with temperatures in the 40s over Southern New England, expect rain across much of the area around dinner time.
Unfortunately, the rain will be widespread for First Night activities so make sure you have your rain gear handy and dress in layers. North of Route 2, that's where the precipitation could start out as a wintry mix and then quickly transition to rain.
The mountains and much of northern Maine will get to rejoice in snow, where 3-6 inches of fresh powder is in the forecast and not expected to see much in the way of rain.
The storm moves out on Tuesday, allowing for the sun to shine on the first day of 2019. It will also be accompanied by highs in the 50s.
Then, it's back to reality on Wednesday with highs in the 30s.
After December's Unusual Lack of Snow, What's Next?
There's a chance we get another storm late week and this one could bring a wintry mix on the onset and then change over to rain. Needless to say, our active pattern will continue into the new year and for now, it looks more wet than white.
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The 1957 Chicago Cubs season was the 86th season of the Chicago Cubs franchise, the 82nd in the National League and the 42nd at Wrigley Field. The Cubs tied with the Pittsburgh Pirates for seventh in the National League with a record of 62–92.

Offseason
 November 13, 1956: Don Hoak, Warren Hacker, and Pete Whisenant were traded by the Cubs to the Cincinnati Redlegs for Ray Jablonski and Elmer Singleton.
 December 11, 1956: Eddie Miksis, Jim Davis, Sam Jones, and Hobie Landrith were traded by the Cubs to the St. Louis Cardinals for Tom Poholsky, Jackie Collum, Ray Katt, and Wally Lammers (minors).
 December 11, 1956: The Cubs traded a player to be named later to the New York Yankees for Charlie Silvera and cash. The Cubs completed the deal by sending Harry Chiti to the Yankees on December 14.
 Prior to 1957 season: Lou Jackson was signed as an amateur free agent by the Cubs.

Regular season

Season standings

Record vs. opponents

Notable transactions
 April 16, 1957: Ray Katt and Ray Jablonski were traded by the Cubs to the New York Giants for Dick Littlefield and Bob Lennon.
 April 20, 1957: Jim King was traded by the Cubs to the St. Louis Cardinals for Bobby Del Greco and Ed Mayer.
 May 1, 1957: Dee Fondy and Gene Baker were traded by the Cubs to the Pittsburgh Pirates for Dale Long and Lee Walls.
 May 23, 1957: Jackie Collum and Vito Valentinetti were traded by the Cubs to the Brooklyn Dodgers for Don Elston.
 June 8, 1957: Chuck Tanner was claimed on waivers by the Cubs from the Milwaukee Braves.
 September 10, 1957: Bobby Del Greco was purchased from the Cubs by the New York Yankees.

Roster

Player stats

Batting

Starters by position
Note: Pos = Position; G = Games played; AB = At bats; H = Hits; Avg. = Batting average; HR = Home runs; RBI = Runs batted in

Other batters
Note: G = Games played; AB = At bats; H = Hits; Avg. = Batting average; HR = Home runs; RBI = Runs batted in

Pitching

Starting pitchers
Note: G = Games pitched; IP = Innings pitched; W = Wins; L = Losses; ERA = Earned run average; SO = Strikeouts

Other pitchers
Note: G = Games pitched; IP = Innings pitched; W = Wins; L = Losses; ERA = Earned run average; SO = Strikeouts

Relief pitchers
Note: G = Games pitched; W = Wins; L = Losses; SV = Saves; ERA = Earned run average; SO = Strikeouts

Farm system

Lafayette franchise folded, June 20, 1957

Notes

References

1957 Chicago Cubs season at Baseball Reference

Chicago Cubs seasons
Chicago Cubs season
Chicago Cubs

redpajama_set_name: RedPajamaWikipedia


Transcription regulatory regions in higher eukaryotes are often represented by cis-regulatory modules (CRM) and are responsible for the formation of specific spatial and temporal gene expression patterns. These extended, ~1 KB, regions are found far from coding sequences and cannot be extracted from genome on the basis of their relative position to the coding regions.
To explore the feasibility of CRM extraction from a genome, we generated an original training set, containing annotated sequence data for most of the known developmental CRMs from Drosophila. Based on this set of experimental data, we developed a strategy for statistical extraction of cis-regulatory modules from the genome, using exhaustive analysis of local word frequency (LWF). To assess the performance of our analysis, we measured the correlation between predictions generated by the LWF algorithm and the distribution of conserved non-coding regions in a number of Drosophila developmental genes.
In most of the cases tested, we observed high correlation (up to 0.6–0.8, measured on the entire gene locus) between the two independent techniques. We discuss computational strategies available for extraction of Drosophila CRMs and possible extensions of these methods.
Recognition of transcription regulatory sequences is one of the most important and challenging problems in modern computational biology. In the case of higher eukaryotes, there are proximal transcription regulatory units, located close to 5' ends of coding sequences and called 'proximal promoters', and distant transcription regulatory units, located further upstream or downstream of the gene and called 'enhancers' or 'cis-regulatory modules' (CRMs). It is clear that identification of a 'proximal' transcriptional unit can be based on its relative position to the coding sequence and the presence of specific transcriptional signals such as TATA box, CAAT box, transcription start site consensus (TSS) and, perhaps, other specific signals (such as downstream promoter elements, DPE). Typical CRMs (or enhancers) possess no such specific features; therefore their annotation in genome is much more difficult.
Currently existing methods dedicated to the recognition of transcription regulatory regions can be subdivided into three main categories: (i) search by signal, (ii) search by content and (iii) phylogenetic footprinting [1–4]. Modern 'search by signal' techniques are based on identification of known transcriptional patterns in DNA sequences, such as clustered binding motifs for known transcriptional regulators [5–10]. Extraction of clustered recognition motifs is among the most reliable current techniques, but it is limited to recognition of similarly regulated cis-regulatory modules in a genome.
Another strategy of CRM extraction from genome is phylogenetic footprinting. Methods of this class assume that regulatory regions contain highly conserved segments and they can be extracted by means of sequence comparison from evolutionary related genomes [11–18]. Performance of the phylogenetic footprinting greatly depends on the evolutionary distance between chosen species and on the conservation level of particular genes from these organisms. Phylogenetic footprinting have become especially important in recent days as more than one genome represents the sequence data for most of the main model organisms. However, it is not clear yet whether phylogenetic footprinting alone is sufficient for precise and exhaustive mapping of CRMs and how many related genomes it will require to achieve this goal. Non-coding conserved regions might also include not only promoter and enhancer regions, but also other functional sequence classes, such as origins of replication, matrix-attached regions etc, so an independent method of CRM extraction might be necessary.
'Search by content' (ab initio) methods are often based on the difference in the local base composition and in the local word composition between the regulatory and non-regulatory DNA [10, 19–21]. It is assumed that the difference is caused by presence of transcriptional signals, such as binding motifs for transcriptional regulators in the regulatory DNA. For example, the presence of multiple copies of the same binding site may change local frequency of short words in promoter regions. This idea was explored by analysis of most frequent hexamers (differential hexamer frequency) , other short words and motifs [23, 24] in regulatory sequences. More recent implementations of the 'search by content' strategy take into account base interdependence in transcription regulatory regions and exploit interpolated Markov chains  as well as local word frequency . General-purpose techniques based on the 'search by content' are of great interest as they provide an independent line of evidence for the recognition of transcription regulatory sequences in genome.
Recognition of regulatory sequences using 'search by content' is still a difficult problem due to the presence of distinct signals in different regulatory sequences as well as high divergence of these signals themselves. In this respect, each particular promoter as well as a given large training set may never contain even a small fraction of all specific words. Beside the binding motifs for transcription factors, the regulatory DNA may also possess patterns with specific physical properties [2, 21] or other functional patterns, such as nucleosome positioning signals [26, 27].
The described diversity of promoters and transcription regulatory signals suggests that methods based on local word composition/local word frequency, regardless of the words themselves, might be more suitable for the CRM and promoter recognition. In this work we describe an exhaustive local word frequency analysis and apply this new technique to recognition of cis-regulatory modules of Drosophila developmental genes. We based our recognition strategy on the assumption that biological signals in any regulatory region possess similar redundant properties, independent on a particular gene, promoter or CRM. According to this assumption, words corresponding to binding motifs for transcription factors might possess one level of redundancy, specific words involved, for instance, in promoter bending might possess another etc.
To describe all these various specific patterns in the context of one DNA sequence segment (resolution window), we represent exhaustive statistical analysis of word frequency, where the local frequency of each word in the DNA segment is taken into consideration, regardless of the word itself. For instance, two DNA segments having similar local word frequencies would produce similar scores, even if the words comprising the two DNA segments were different. In this respect, the proposed strategy aims to identify sequence segments containing specific word distributions rather than sequence segments containing specific words or arrays of specific words. In this sense our new method resembles promoter recognition techniques based on local assessment of most frequent words (hexamers) , but it is superior as it takes into consideration the full range of word frequency and scores even unique words.
Typically, the efficiency of a promoter recognition algorithm is evaluated with the help of an annotated promoter database, such as EPD . The database contains proximal promoter elements, and is very helpful for evaluation of methods based on recognition of specific words, such as proximal transcriptional signals represented by the TATA box, transcription start site (TSS) and others. However, a vast majority of eukaryotic transcription regulatory regions located far upstream or far downstream of TSS contain no proximal signals. Therefore, to test the performance of the proposed new technique we developed a unique training set of sequence data, based on cis-regulatory modules (CRMs) of Drosophila developmental genes, transcription regulatory regions from higher eukaryotes, located far from gene coding sequences and TSS.
The developmental genes of Drosophila comprise spatio-temporal cascade (network) of regulatory interactions, responsible for early pattern formation of the developing fly embryo [29–32]. This model system has several advantages that make it unique in computational sequence analysis: (i) The majority of the genes encode transcription factors that are connected into the network of direct transcriptional interactions. (ii) For most of the developmental genes (Bicoid, Hunchback, Krüppel, etc) large amount of experimental data is available at the genetic, biochemical and evolutionary (comparison between species) levels, including positions of their cis-regulatory modules and description of binding motifs for upstream regulators.
We compared the results of our word frequency analysis of Drosophila melanogaster developmental genes with a reference data, generated by phylogenetic footprinting (percent identity profiles, PIP) of the same genes using recently sequenced genome of Drosophila pseudoobscura. This comparison has revealed a striking agreement between predictions generated by the two independent methods.
Recognition of regulatory sequences using 'search by content' approach requires representative training set of sequence data, ideally, a set of functional transcription regulatory regions. For this reason we assembled and annotated all published experimental data for the early developmental enhancers of Drosophila. These data include three major types of information: (i) sequence data for experimentally tested CRM regions, (ii) binding motifs for known transcriptional regulators, and (iii) known regulatory interactions between the early developmental genes.
To assemble the CRM sequence data, we retrieved published deletion analysis data for more than 60 CRMs from 20 different developmental genes. To navigate through this sequence collection, we created an interactive database containing two major structural levels (see Figure 1). The top level comprises a list of genes, and references to the corresponding sources in the literature. The bottom level consists of an interactive map, describing the position of all known functional elements (coding sequences and enhancers) in each gene locus (loci ranged in size from 16 to 120 Kb). The exact location of each functional element is presented in a table below the map, along with a description of any known regulatory interactions mediated by the element. The bottom level also contains an annotated text of the locus sequence with highlighted functional regions. In addition, we aligned footprint data for 28 binding motifs, representing the majority of the maternal, gap, pair rule, and some segment polarity genes. For each alignment, we established the optimal motif width, and outlined a well-defined core formed by positions with high information content. This data is also available from our interactive database.
Interactive collection of CRMs. Window on the left shows the upper level of the annotation with the list of genes and references, window on the right displays the bottom level containing interactive functional map of a gene locus and the sequence of the locus with highlighted functional regions. Red bars correspond to early and orange bars to late CRM regions; yellow bars mark exons. Exact positions of the highlighted functional regions are given in the table below the interactive map. Binding motifs are available from the upper level of the annotation.
In comparison with existing dedicated databases, such as GeNet [33, 34], our compilation is focused on available deletion and footprinting data and it is convenient for: (i) fast navigation and retrieving of CRMs and (ii) fast retrieving of the binding motifs involved in a given regulatory interaction. All annotated data are publicly accessible from New York University web site http://homepages.nyu.edu/~dap5.
We considered it irrelevant to construct positive training set from the entire CRM collection directly as the positions of the CRM boundaries identified by empirical deletion analysis are quite arbitrary. In most of the classical deletion studies the boundaries of a deletion fragment were defined according to the presence of convenient restriction sites. This fact, along with the limit on a possible number of deletion combinations (number of transgenic constructs) resulted in a lack of precise resolution of the deletion analysis technique. In many cases the identified by the deletion technique minimal regulatory elements (such as MSE – minimal stripe enhancers) still provide correct spatial distribution of expression patterns, but the rescued patterns contain only a fraction of the endogeneous gene expression levels.
To minimize the effect of possible errors caused by the insufficient resolution of the deletion technique and to develop a formal principle of the positive training set construction, we defined CRM boundaries based on position of clusters of binding sites for transcription factors, involved in the CRM regulation (see Figure 2). In our previous work , we have demonstrated that positions of binding site clusters for these regulators correlate well with the positions of the CRMs, identified previously using deletion analysis. In a number of related studies [7, 8, 10] it has also been demonstrated that the binding motif clusters can be effectively used for mapping CRMs in the genome. Therefore, we constructed our positive training set from sequences containing the most significant clusters of binding sites for five transcription factors (Bicoid, Hunchback, Krüppel, Knirps and Caudal), involved in the regulation of many genes in our CRM database. The vast majority of these clusters overlaps the deletion analysis data, as it has been demonstrated earlier .
Strategy of CRM extraction. Input training data for word frequency analysis represent genome of D. melanogaster and CRM sequences refined by search for regulatory clusters using binding motifs for transcription factors: Bicoid, Hunchback, Krüppel, Caudal and Knirps . The results of word frequency analysis are compared with results of phylogenetic footprinting.
Despite the fact that we used only five transcription factors to evaluate sequences for a positive training set, the resulting training sequences contained many other binding motifs (yet unknown), present in CRMs. Thus, the five chosen motifs served us as markers only, indicating positions in the sequences that belong to cis-regulatory modules. The total size of the described positive training set comprised more than 68 Kb of sequence data and contained 58 homotypic clusters in 33 non-overlapping contigs. Sequences of the positive training set, including identified homotypic clusters in the gene locus regions are available from our database: http://homepages.nyu.edu/~dap5/PCL/pseudoobscura/train_plus_contigs.zip.
We also generated several negative training sets, one containing random samples (50 Kb each sample) from genome of Drosophila melanogaster, one containing random samples from Drosophila CDS collection  and one containing non-coding sequences only. Each negative training set combined >2 Mb of sequence data (>1.5% of the Drosophila genome).
One can describe frequency F of a word in i th position of a DNA sequence through a number of matches found for this word inside a w-window (detection window), centered on the word (See Figure 3, 3A). Presence of binding motifs and other transcriptional signals affects the word frequency, but, in most cases, it is not known which functional signal corresponds to what frequency level. Therefore, consideration of only words with a given frequency level, for instance 'most frequent' words (high F), may result in a loss of functional information. To collect the information exhaustively, we take into consideration local frequency F of each word (or each position) in a sequence segment. Then, we group (sort) all words in a sequence segment according to their frequency F into separate frequency channels, where the feature score S j (i) in a frequency channel j represents the total number of words (positions) in a window l (resolution window) having a frequency from a fixed range of the frequency value: j ≤ F < (j + n), (j, n ∈ N) (See Figure 3, 3B). For instance, if j = 1, n = 0, the feature score S j (i) of the resulting frequency channel represents the total number of unique words (having F = 1) in a resolution window l. In contrast, high values of j describe frequency channels that account for highly repetitive words. High values of n define 'wide' frequency channels, combining words with distant frequency values. Combination of all non-overlapping frequency channels in the range of w >F > 0 covers full spectrum of word frequency detected in the window w. Independent consideration of the feature score S in each frequency channel represents multiresolution analysis of our main feature, word frequency.
Local word frequency algorithm. (A) Degree of local (detection window w = 500) word frequency F (Y-axis) in every position of the even-skipped locus, generated for words n = 2. (B) Feature score values S (see colorbar) obtained from the LWF analysis of the same DNA fragment. Each frequency channel (Y-axis) accounts for words in a limited range of word frequency only (shown in brackets). Feature score values represent total number of words, having similar F in a resolution window l (in the case shown l = 500).
A partition of the spectrum into non-overlapping frequency channels may be set differently and highly depends on other parameters such as the size of the resolution window and the size of the word. In the current work we considered only short words (2–4 bases), assuming that a functional transcriptional signal (for instance, transcription factor binding site), must have a conserved core, which is often only a small fraction of the functional word . Another advantage of short words is that they have much greater local frequencies, which facilitates statistical analysis and allows construction of spectra with larger number of wide non-overlapping frequency channels. For the same reason, wider windows (w, l) are preferred, but the upper size of the window is limited by the desired resolution of the method. In the case of our model system, Drosophila CRMs, we considered equal detection and resolution windows (w = l) that are close to the size of the minimal known CRM sequences and vary within the range of 0.5–1 Kb.
Mathematical expectations M(S) and distributions of the feature score E(S) obtained for positive and negative training sets are given in Figure 4A, 4B. In some training sets we obtained distributions that are very close to Poisson in several frequency channels. However, that was not common, especially in the case of frequency channels accounting for unique or very frequent words. For this reason, we have used the E-values, obtained directly from the distributions that were smoothed to reduce statistical noise.
Classification of a sequence segment. (A) Mathematical expectation for the feature score S in different frequency channels (X-axis, shown in brackets), calculated as M(S) = Σ S k E (S k ) from distribution E(S) for words n = 3. (B) Distribution E(S) of the score S in the frequency channel corresponding to 5 ≤ F < 7 and the resulting likelihood score Λ (S). Effect of corrections applied to the final likelihood score is shown for two values of σ.
Thus, in each frequency channel j, each position of the test sequence i obtains a log-likelihood score L ji , which displays chances that the i-th window of the test sequence belongs to a positive (ω1) or a negative (ω2) training set. In this work, we consider only the simplest case, where the contribution of each frequency channel into the recognition is equal (equal weights). Therefore, we calculated the resulting score R i for the i-th window as a sum of scores L ji for all frequency channels. On practice, we used more sophisticated formula (see below) to calculate and correct the score R i , but even the simplest approximation produced relevant results.
To assess the quality of our word frequency classification algorithm on the same system of early Drosophila genes, we adopted an additional reference set of data that independently marks positions of transcription regulatory modules in the analyzed sequences.
To construct this independent reference dataset we took advantage of the existing tools and strategies [13, 16] and generated conservation profiles (percent identity profiles, PIPs) for wide genomic regions of 16 early developmental gene loci, representing the majority of genes from our database. We retrieved from the recently published genome of D. pseudoobscura (Human Genome Sequencing Center at Baylor College of Medicine) all contigs corresponding to the 16 selected genomic regions of D. melanogaster, and produced the conservation profiles using available standard procedures. The assembled sequences for the developmental genes of D. pseudoobscura along with the graphical data for alignments and numerical data for conservation profiles are publicly available from New York University web site http://homepages.nyu.edu/~dap5/PCL/pseudoobscura/pseudoobscura.htm.
We measured correlation (Pearson Association Coefficient) between the likelihood profile obtained from the word frequency analysis and the conservation profile, both constructed independently for each of the 16 developmental gene loci from our annotation. We also measured correlation of the likelihood profile and the conservational profile with the positions of annotated CRMs (deletion data). Some of the described results are shown in Figure 5; correlation values for the loci of 16 developmental genes are given in Table 1. One can see that the both independently constructed profiles correlated with each other very well in almost all cases. This important finding suggests that genomic DNA segments possessing word frequency of regulatory clusters (positive training set) correspond to highly conserved regions.
Extraction of CRM sequences using local word frequency algorithm. (A-D) The statistical LWF profiles (Λ) are compared with the conservation profiles (PIP) constructed for loci of several developmental genes of D. melanogaster. Map of functional CRM regions (deletion analysis data) is given on the bottom of each panel. Correlation (cc) between the statistical (blue line) and the conservation profiles (green line) was measured for the entire locus sequence (see Table 1). Notice that we put percent of sequence identity to zero in exons (yellow bars in the functional map), thus penalizing the correlation value if the word frequency algorithm produced positive score in these regions (see B).
Correlation between the LWF and the conservation profiles. The table shows values of Pearson Association Coefficient (cc) , measured on the entire gene loci sequences (gene names are in the first column). The best correlation (fourth column) was observed between the statistical profiles (Λ) obtained from word frequency analysis and the conservation profiles (PIP). Lower correlation between ether the statistical (Λ/deletion) or conservation (PIP/deletion) profiles with the deletion data supports low resolution of deletion analysis (see results, 'construction of positive and negative training sets'). Jackknife test results are shown (in red typeface) for selected loci that contributed the largest fraction of sequences to the positive training set. The corresponding profiles are shown in Figure 7 [see Additional file 1].
We performed the described word frequency analysis using three different negative training sets: random samples (50 Kb sample size, total of 2 Mb sequence data) from genome of Drosophila, random samples from Drosophila cDNA collection and genomic samples containing non-coding DNA. Genomic samples and non-coding sequences resulted in better correlation of the likelihood profile with the conservational profile and with the deletion data (annotated CRMs) than coding sequences. Figure 7 [see additional file 1] shows comparison of performance of LWF algorithm, trained on different datasets. We also compared prediction accuracy of LWF algorithm with prediction accuracy of phylogenetic footprinting. Results of a benchmarking test shown in Figure 6 demonstrated better performance of LWF in extraction of known CRM regions (deletion data). A combination of the two independent approaches allowed further improvement of the prediction accuracy (see Figure 6, 6C).
Prediction accuracy on a wide genomic region. Prediction accuracy (ROC) measured for the loci shown in Figure 5. Amount of true positives (TP, green line) is equal to the fraction of correctly predicted DNA positions in CRMs, calculated for different cutoff values. Blue and red lines show the rate of false-negatives (FN) and false-positives (FP) correspondingly. (A) Prediction accuracy based on sequence conservation (PIP) between the two Drosophila species, (B) prediction accuracy based on word frequency analysis, (C) an example of a combined approach; moderate filtering for non-conserved regions (below 30%) allows further improvement of the prediction quality as in (B).
Exhaustive mapping of the exact CRM distribution in developmental genes of Drosophila is an extremely important biological task. In its turn, evaluation of novel regulatory sequences in this particular system leads to generation of better training sets for further genome-wide CRM recognition and facilitates computational mapping of binding motifs and other transcriptional signals comprising CRMs.
In this work we compared outputs of two independent computational techniques, the word frequency analysis and the phylogenetic footprinting and have shown that both methods generate highly correlated predictions. Most surprising is that the correlation between the two independent approaches is much higher than the correlation of either one with the deletion analysis data (annotated CRMs). In some cases lower correlation between positions of predicted and the known CRMs (deletion analysis) is explained by the conservative design of our formal tests (see Table 1 and Figure 6). We assumed that in each locus (i) all CRMs are known and (ii) their boundaries are mapped precisely. In reality a vast fraction of the sequences comprising the considered loci (16–25 Kb) were never tested for CRM activity and the CRM boundaries represent an interpretation of empirical biological tests that are often difficult to formalize. At the same time word frequency algorithm produced very high positive scores for many of the best known 'classical' developmental CRMs, such as eve stripe 2, eve stripe3+7, eve stripe 4+6, kr CD1, ftz zebra and many others (see Figure 5). Correct recognition of these 'classical' elements, analyzed by many independent experimental groups, strongly supports relevance of our word frequency analysis.
The good agreement between the two independent techniques (word frequency and phylogenetic footprinting) and the successful recognition of the most known CRMs demonstrates the power of our strategy in extraction of CRMs from developmental genes (see Figure 2). It is important that using positive training set based on clusters of early developmental transcription factors we also extracted some of the late (expressed at later stages of fly development) CRM elements that were not among the training sequences. This suggests that our learning method accounts for general features (such as word distributions) inherent to regulatory DNA, rather than for particular motifs and words, specific to particular promoters/CRMs.
It is early to say what strategy will finally dominate in recognition of transcription regulatory regions. Apparently, at the current stage of this field, cross-validation using several independent techniques seems to be the most appropriate solution.
To analyze the functional properties of transcription regions, we assign frequency value F to each word of a sequence segment. This procedure results in a signal, where every position of DNA contributes one sample. At the following step we partition the frequency spectrum into frequency bands (frequency channels) containing words with similar frequency properties and analyze each frequency band (channel) independently. We take into account the full spectrum of word frequencies in our detection window; therefore for a chosen window size our assessment is exhaustive. Major advantage of this multiresolution analysis is its ability to produce highly informative pattern models, which minimize loss of information and facilitate recognition of very uncertain DNA patterns. In our case, for instance, a combination of non-overlapping frequency channels collects maximal information about the local word frequency in a sequence segment. All this information contributes to the final likelihood score. Direct extraction of words with defined frequencies (single frequency channels) may also have its specific field of application, different from promoter recognition. For example, one can filter out undesirable signals (noise) by combining or subtracting different frequency channels. This preprocessing may facilitate further extraction of biological signals such as binding motifs or nucleosome positioning signals using other techniques.
In this work we select word frequency F as our main feature, however there is a good number of various transformation functions that were already implemented for the analysis of biological sequences [38–40]. Most of these functions are based on analysis of local base composition and local base frequency. It is interesting to emphasize here, that if we accept size of the word equal to 1, then the described word frequency analysis becomes 'local base frequency analysis'.
For many types of signals, such as speech and images, most of the information is localized in certain resolution (scaling) levels. In the case of biological sequences the resolution level or size of the resolution window can be selected equal to the size of known functional regions, such as cis-regulatory modules, analyzed in this work. Nevertheless, in many cases it is not known if the selected resolution window is optimal. In our recent work  we evaluated biological signal (clustered binding motifs) in a broad scaling range and developed a procedure that allows establishing the size of the optimal resolution window. That application also might be considered as a multiresolution analysis, but relatively to the scaling range (resolution window l in our case).
Applications based on the multiresolution analysis are relatively new in the field of promoter study and they still require careful feature selection and thorough biological interpretation of obtained patterns. The last type of problems, however, can be solved in the context of well-known biological systems such as Drosophila developmental enhancers (CRMs), where accumulated biological information and annotated sequence data create very comfortable environment for such exploration.
This formula takes more simple form if the distributions are known , which is not exactly our case (see results).
This multiplier ν is a normal distribution of the likelihood score L with expectation M = 0 and standard deviation σ. For very high positive or very high negative values of L, the value of the multiplier approaches zero, suppressing possible dramatic difference between channels. Behavior of the corrected likelihood score Λ j at the different values of parameter σ is given in Figure 4B.
A.N. participated in annotation of Drosophila cis-regulatory modules and computational analysis. D.P. carried out programming and database construction. Both authors read and approved the final manuscript.


text:
news, world
North Korea has carried out a "very important" test at its Sohae satellite launch site, state media KCNA reported on Sunday, a rocket testing ground that US officials once said Pyongyang had promised to close. The reported test comes as a year-end deadline North Korea has imposed nears, warning it could take a "new path" amid stalled denuclearisation talks with the United States. The KCNA report called it a "successful test of great significance" on Saturday but did not specify what was tested. South Korea's defence ministry said South Korea and the United States are cooperating closely in monitoring activities at major North Korean sites including Tongchang-ri, the area where Sohae is located. Missile experts said it appeared likely the North Koreans had conducted a static test of a rocket engine, rather than a missile launch, which are usually quickly detected by neighbouring South Korea and Japan. "If it is indeed a static engine test for a new solid or liquid fuel missile, it is yet another loud signal that the door for diplomacy is quickly slamming, if it isn't already," said Vipin Narang, a nuclear affairs expert at the Massachusetts Institute of Technology in the United States. "This could be a very credible signal of what might await the world after the New Year." Tensions have risen ahead of a year-end deadline set by North Korea, which has called on the United States to change its policy of insisting on Pyongyang's unilateral denuclearisation and demanded relief from punishing sanctions. On Saturday North Korea's ambassador to the United Nations said denuclearisation was now off the negotiating table with the United States and lengthy talks with Washington are not needed. "The results of the recent important test will have an important effect on changing the strategic position of the DPRK once again in the near future," KCNA reported, using the initials of North Korea's official name, the Democratic People's Republic of Korea. Australian Associated Press
https://nnimgt-a.akamaihd.net/transform/v1/crop/frm/silverstone-feed-data/903d771d-e49c-42b5-be6c-87ee9e239b00.jpg/r0_74_800_526_w1200_h678_fmax.jpg
NKorea carries out "important" test
North Korea has carried out a "very significant" test at its Sohae satellite launch site.
North Korea has carried out a "very important" test at its Sohae satellite launch site, state media KCNA reported on Sunday, a rocket testing ground that US officials once said Pyongyang had promised to close.
The reported test comes as a year-end deadline North Korea has imposed nears, warning it could take a "new path" amid stalled denuclearisation talks with the United States. The KCNA report called it a "successful test of great significance" on Saturday but did not specify what was tested.
South Korea's defence ministry said South Korea and the United States are cooperating closely in monitoring activities at major North Korean sites including Tongchang-ri, the area where Sohae is located.
Missile experts said it appeared likely the North Koreans had conducted a static test of a rocket engine, rather than a missile launch, which are usually quickly detected by neighbouring South Korea and Japan.
"If it is indeed a static engine test for a new solid or liquid fuel missile, it is yet another loud signal that the door for diplomacy is quickly slamming, if it isn't already," said Vipin Narang, a nuclear affairs expert at the Massachusetts Institute of Technology in the United States.
"This could be a very credible signal of what might await the world after the New Year."
Tensions have risen ahead of a year-end deadline set by North Korea, which has called on the United States to change its policy of insisting on Pyongyang's unilateral denuclearisation and demanded relief from punishing sanctions.
On Saturday North Korea's ambassador to the United Nations said denuclearisation was now off the negotiating table with the United States and lengthy talks with Washington are not needed.
"The results of the recent important test will have an important effect on changing the strategic position of the DPRK once again in the near future," KCNA reported, using the initials of North Korea's official name, the Democratic People's Republic of Korea.


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/ DC
Injustice 2
James Gunn Addresses if The Suicide Squad is a Reboot or Sequel
By Megan Peters - May 22, 2019 04:35 pm EDT
The last year has been a bumpy one for director James Gunn, but it seems things have finally settled with his career. After being removed as the director of Guardians of the Galaxy 3, the filmmaker was picked up by Warner Bros. Pictures to take care of The Suicide Squad. Now, Gunn is set to oversee both films, and he's ready to address the status of the DC Films venture.
However, that doesn't mean he is going to give away any secrets. Gunn has got some locked lips, and he isn't spilling any beans on The Suicide Squad.
Recently, Entertainment Tonight got to chat with Gunn during a press event for the film Brightburn. It was there the director was asked about The Suicide Squad's status as a reboot or sequel. So, Gunn had the following to say:
"You know, these terms are all so narrow. There are so many terms," he said before adding, "It is what it is. You'll see in two years when it comes out."
For fans, this reveal has simply reaffirmed the fact that Gunn is keeping his secrets close to chest. As pre-production continues on The Suicide Squad, details are in constant flux, but Gunn has at least spoken about his feelings towards the project. Speaking with Entertainment Weekly, Gunn said he is "enormously excited" abut the film.
So far, few confirmed details about The Suicide Squad have gone live, but Gunn has kept fans posted on social media. He used Instagram earlier this spring to share his own Suicide Squad research with followers, and it was there the filmmaker revealed his favorite comic run.
"I have been an enormous fan of #SuicideSquad in all its @DCComics incarnations - but to me there will always be something special about the #JohnOstrander run," Gunn wrote. "Black ops military tales with disposable, often forgotten super villains?! Pure perfection. Photo of my own collection."
So, what do you want Gunn's venture to be? Let me know in the comments or hit me up on Twitter @MeganPetersCB to talk all things comics and anime!
The Suicide Squad hits theaters on August 6th, 2021. Other upcoming DC films include Joker on October 4th, Birds of Prey on February 7, 2020, Wonder Woman 1984 on June 5, 2020, and The Batman on June 25, 2021.
Harley Quinn and The Joker: Sound Mind Review: A Fresh Origin That May Require Re-evaluation
Dave Bautista Comments on Bane Role in James Gunn's DC Universe and Why It Wouldn't Happen
Dave Bautista Says He'd Love to Be a Part of James Gunn's DC Universe (Exclusive)
Constantine 2: Keanu Reeves Says He Annoyed Warner Brothers Until Studio Agreed to Sequel


Commissioned by Prof Seymour Rabinovitch in 2005, the last in his collection of 99 broad based servers. They are now part of the Victoria and Albert Museums silver collection.
Flat Double skinned folding slice with three hinges that turn on multiple knuckles. An ingenious disposition of hidden small circular magnets hold the leaves in place. The server shows the understanding of practical function and integration with human capability that characterize his designs.
"I first met Christopher at an exhibition of the work of young smiths at the Goldsmiths' Hall. I was taken by the fact that his serving pieces that were on display showed a keen interest in, and attention to the physical aspects of their use. His designs revealed a subtle understanding of shape and its integration in use with human and anatomical function."


A deeper fundamental understanding of complex materials may now be possible, thanks to a pair of Princeton scientists who have uncovered a new insight into how crystals form.
The researchers' findings reveal a previously unknown mathematical relationship between the different arrangements that interacting particles can take while freezing. The discovery could give scientists insight into the essential behaviors of materials such as polymers, which are the basis of plastics.
Molecules in a material cooled to absolute zero can take on a multitude of different configurations. Historically, scientists' difficulty with identifying crystallized molecules' spatial arrangements from this high number of possible configurations has blocked theoretical efforts to understand these materials' qualities, but the new findings could offer the tool that science needs.
"We believe our 'duality relations' will be a useful theoretical tool to understand how individual particles come together to form a crystal," said Salvatore Torquato, a professor of chemistry who co-wrote the paper with senior chemist Frank Stillinger. "If we can tune the interactions among particles that form a crystal, we might be able to create materials that respond to light or mechanical stress in novel ways."
A material that maintains its exact size and shape through extremes in temperature, for example, might be valuable in the manufacture of orbiting space telescopes, whose mirrors need to retain their shape as they pass from sunlight into the Earth's shadow.
A crystal is the state of matter that is easiest to analyze because its frozen molecules are motionless and often regularly organized. A crystal's properties -- its ability to bend light, for example -- generally reveal valuable information about how its constituent molecules will behave at higher temperatures, such as when they become a liquid.
The challenge is that many complex materials can crystallize into a multitude of different structures. When a substance is cooled to nearly absolute zero, and it can take on an enormously large number of possible "ground states" -- the term for the molecular arrangement with the lowest possible energy. Scientists seek to determine the true ground state because it provides a fundamental understanding of matter in the solid state and its possible uses. However, determining which molecular pattern is the true ground state requires mathematical proof that is hard to come by.
"We resort to approximations," said Christos Likos, a professor of theoretical physics at the University of Dusseldorf in Germany. "They help us produce meaningful results sometimes, but we need to have a lighthouse occasionally to show us we're on the right path. Such lighthouses are rare in this business, but Sal and Frank have found one."
Torquato and Stillinger's findings explore particles' behavior as they attract and repel each other over varying distances. By analyzing this behavior, the scientists were able to conceive a precise mathematical correspondence -- called duality relations -- between possible arrangements of particles. The work will enable the researchers to draw important conclusions about how particles at very low temperatures interact over great distances, a situation that is very difficult to treat theoretically.
"Once ground states can be determined and controlled with certainty, scientists might create materials with properties virtually unknown in nature," Torquato said.


text:
<!DOCTYPE html>

  <meta charset="UTF-8">
  <title>Pocket for eReader</title>
  <meta name="viewport" content="width=device-width, initial-scale=1">
  <link rel="stylesheet" href="/css/style.css">

    <form method="POST" action="/login">

Pocket for eReader

      <button>Login with Pocket</button>
    </form>

redpajama_set_name: RedPajamaGithub


text:
class IIndexer:

    def __init__(self, obj):
        pass

    def _get_document(self):
        pass

    def index(self, recursive=False):
        pass

    def unindex(self, recursive=False):
        pass

    def reindex(self, fields=[], recursive=False):
        pass

    def index_file_content(self, recursive=False):
        pass

class QuerySet:

    def anyof(self): pass

    def sum(self): pass


Popper fastener style pocket nappy, featured with adjustable cross over waist snaps secure the nappy probably and snugly, and hip snap buttons prevent wing drooping.
One size suit all, easy adjusting into different sizes that grow with baby, fit from new born to potty around 3-15KG.
1, Microfibre – 3 layers, super absorbency, quick drying, soft and durable.
2, Bamboo – 4 layers ( 2 layers of bamboo and 2 layers of microfiber core ), improved design that combine both advantage of bamboo and microfibre material, for quick and enhanced absorbency.
To Use Nappy – just stuffing nappy inserts from pocket opening on the back of waist, Separate them when washing for quick drying time.
Fitting – first adjust nappy size, then adjust waist snap closure to suit baby's waist, and make sure it is snugly around thigh to prevent leaking.


text:
Чёрный Кей (, ) — река в ЮАР. Протекает по территории Восточно-Капской провинции. Её истоки расположены в горах Винтерберге, к юго-западу от города Куинстаун. Основные притоки — Клас-Смитс и Клипплат. Северо-восточнее города Каткарт сливается с рекой Белый Кей и образует реку Большой Кей. На берегах реки расположено несколько деревень. Часть реки формирует западную границу заповедника Тсолвана. В XIX веке Чёрный Кей и её приток Клипплат формировали северную границу Британской Каффрарии.

Примечания

Бассейн Большого Кея
Реки Восточно-Капской провинции


Smoking is a leading cause of preventable disease and death.
The Northern Territory prison population comprises 92% Indigenous Australians and 88% smokers. The NT prison-smoking ban creates a population-wide abstinence. We aim to extend this period of abstinence into the community.
This project will estimate the social and economic costs related to tobacco use in NSW for 2014. Mortality and morbidity costs attributable to smoking will be estimated as will lost productivity, costs due to fires and the intangible costs due to mortality attributable to smoking.
The overarching objective of this project is to produce as comprehensive as possible an estimate of the costs of methamphetamine use to Australian society. The intention is also to develop an approach that could be applied in a consistent manner to other drugs in the future.


I am trying to set up a small intranet and was wondering if there is a way to determine the client's workstation name (for example, Computer Name in Control Panel/Identification). I can then interrogate a database and generate a form to indicate what applications this workstation is licensed for.
HTML isn't sophisticated enough to determine that information and scripting languages have that kind of check turned off. However, the Windows API can be very useful in providing this kind of information, but to access it through a Web application, the code would have to run within a compiled component, such as an ActiveX control or ActiveX document. The Windows API named GetComputerNameA can do this task nicely. You can either call GetComputerNameA directly or create a wrapper function around it, then call your wrapper function.
For example, if you insert the following code into your custom ActiveX control, you can get the client computer's name to appear in a Message Box. By the way, this code will work in other types of VB projects, as well.
' have a command button on a form named Command1.


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Manufacturers >Media 100, a unit of Optibase, has hired long-time Avid product designer Steve Bayes as director of product marketing. He will oversee and roll out Media 100's 10-bit HD and SD editing system, Media 100 HD; new versions of the company's 844/X realtime editing-compositing solution; and future Media
>Media 100, a unit of Optibase, has hired long-time Avid product designer Steve Bayes as director of product marketing. He will oversee and roll out Media 100's 10-bit HD and SD editing system, Media 100 HD; new versions of the company's 844/X realtime editing-compositing solution; and future Media 100 products for the Mac and PC.
>Uzi Breier has joined Optibase as chief executive officer. Breier, who most recently served as chief executive officer of Emblaze Semiconductor, will be in charge of the company's business plans and strategies. Optibase also recently appointed Adam Schadle president. He will oversee all of the company's U.S.-based activities.
>Pace Micro Technology has promoted Chris Dinallo to vice president of technology. He will work on on-going business, new business development, and direct technical point of contact for MSOs. Additionally, Steve Payne has joined Pace as director of operations and finance. He will be responsible for all operational aspects of the company.
>Solid State Logic (SSL) has appointed Thomas Jensen service manager and Phill Scholes service engineer for the New York office. Both Jensen and Scholes have moved from SSL's headquarters in England to lend their skills to the SSL eastern region office.
>Roger Henderson, former CEO of Chyron, has been appointed chairman of Trilogy Broadcast. Trilogy also tapped Mike Knight, former general manager of Pro-Bel and a senior vice president of Chyron, as CEO. Roger Stanwell, who has been managing director of Trilogy since its formation in 1986, will become commercial director.
>Frank Rocco has joined Wohler Technologies as director of marketing. His initial projects include major marketing initiatives to promote wider recognition of Wohler Technologies' new achievements in advanced in-rack audio and video monitoring products.
>Rick Oster has been promoted to executive vice president, general sales manager, at Adlink. In this position several Adlink vice presidents will report to Oster. He will continue to lead and oversee the Adlink sales team.
>Company 3 has hired visual effects editor Brian Robinson. Robinson, who has more than 20 years of experience under his belt, will operate out of a newly built compositing suite equipped with a Discreet fire system at Company 3's Santa Monica facility. He will also have access to the facility's Quantel iQ system for feature film and other film-based editorial work. He has worked as a freelancer for the past three years as the owner and operator of Independent Post and 503 Post.
>Masque Sound has named Michael Descoteau director of broadcast services. He will coordinate the expansion of the company's broadcast services division.
>Writer/producer Phil Lollar has joined Renegade Animation as director of development. He will develop episodic television, feature film, DVD, and other entertainment projects for the animation studio. Director of development is a newly created position for Renegade, and part of the company's effort to grow the entertainment side of its business.
>The Satellite Broadcasting and Communications Association (SBCA) has announced Steven Hill as vice president for training and technology. He will oversee many aspects of SBCA's education and National Standards and Testing Program (NSTP). His focus will be on expanding and developing the current education and training programs and creating new programs in broadband and trouble-shooting.
>ASSOCIATIONS
The New York Production Alliance has announced the formation of a new board of directors, designed to carry the six-year-old group through the next stage of its pro-bono mission. TeleVest's Phil Dixson will serve as co-chairman, along with John Johnston of Eastman Kodak.
<b class="h1r"> People</b>
Manufacturers > Chyron has appointed Bill Hendler vice president and chief products officer. He will be responsible for overseeing product management for the company's hardware and software products. He has been with Chyron for almost 25 years and was most recently vice president of its Media Solutions Group.
Networks & Stations Clear Channel Entertainment Television (CCE TV) has named Steve Sterling senior vice president. Marc Forest has been named vice president, programming and production. In his new position, Sterling will focus on the development and worldwide distribution of the full range of CCE TV's music
Networks and Stations > Chris Ender has been promoted to senior vice president of communications at CBS . He will oversee publicity and communications functions for all of CBS's West Coast programming divisions, including CBS Entertainment, UPN, and King World. > EchoStar 's president and chief operating
Networks & Stations >Dr. Deborah Cross MacFarlane has joined public broadcaster Thirteen/WNET New York as director of development and membership. She will lead the station's efforts to raise funds from individual donors and will be responsible for setting strategic directions and achieving budget and revenue
Networks & Stations >The YES Network has named Tracy Dolgin president and chief executive officer. The former president of Fox Sports Net, which operated more than 20 regional sports networks across the country, Dolgin comes to the network with extensive experience in the regional and national sports televisi
Mike Fazzi has been appointed Regional Sales Manager for the Eastern U.S. (east of the Mississippi and Ohio rivers) by Communications Specialties, Inc. (CSI). Based out of his office in Weems, VA, Fazzi will work with CSI's resellers and end users providing system integration solutions for the company's lines of fibe
Networks & Stations >Dean Macdonald, executive vice president and chief operating officer of Rogers Cable, has left the company. He has worked with Rogers in a number of capacities since 2001, when Rogers purchased Cable Atlantic, a Newfoundland cable company, of which Macdonald was a principal. Manufact


text:
Wonderful service from start to finish.
Action for Brain Injury Week focuses on social isolation after a year of Covid-19
AuthorDan Thompson
We have all had to adjust to a life in some level of isolation over the last 12 months, however for some that isolation has been harder to endure, particularly those who have sustained or are recovering from a brain injury. Action for Brain Injury Week, which falls this year from 17th to 23rd May, will aim to raise awareness of how Covid-19 and the subsequent lockdowns has impacted those individuals recovering from a brain injury. Dan Thompson, Partner in our Personal Injury team, here explains more about the week, highlighting why those with brain injuries have particularly struggled and also reviews the additional impact that the pandemic has had on rehabilitation services.
How has Covid-19 and lockdown impacted those with a brain injury?
A brain injury, whether traumatic or acquired, will have life changing consequences for the individual and their family and friends around them. Some of the most common side effects of a brain injury are memory loss, speech impediments and an inability to adjust to new surroundings or environments, all of which will understandably have a negative impact on the person's confidence.
"With this in mind, it is clear to see why people in this situation will have found lockdown unsettling," explains Dan. "They may have found it difficult to communicate with their friends and family via video conferencing, or they may struggle with communication when in public perhaps not remembering the regulations regarding social distancing or wearing their mask. In addition to these social skills, restrictions have also led to care facilities, support grounds and rehabilitation services being reduced, having a detrimental impact on their short and long term recovery."
In June 2020, Headway conducted a report, The impact of lockdown on brain injury survivors and their families, with the key findings showing that:
57% of people who have suffered a brain injury in the last two years say that their access to specialist rehabilitation treatment has been negatively impacted due to Covid-19.
Two thirds of respondents reported a negative impact on their physiological wellbeing.
64% of those living with the long term effects of a brain injury reported deterioration in their mental health due to the restrictions implemented to control the coronavirus.
50% have lost access to vital support that helps them cope.
65% feeling isolated.
Isolation is often a common result of a brain injury due to a change in behaviour, personality and emotions that follows. Many people experience issues with irritability, lack of empathy and a loss of control, all of which can break up social networks. In fact, a 2018 Headway survey showed that 69% of people experienced a loss in friendships and 44% a breakdown in family relationships following a brain injury. Covid-19 however has only highlighted the importance of maintaining as many relationships as possible in order to offer support at a time when other networks aren't available.
How has rehabilitation been impacted by Covid-19?
The strain placed onto the NHS during the early months of Covid-19 and the following peaks in case numbers led to a redistribution of medical resources and therefore caused a delay and reduction in rehabilitation services.
Early intervention with rehabilitation is vital following a brain injury and has a crucial role to play in the long term recovery, helping the individual to regain lost skills such as walking and talking, aiding them towards an independent life in the future. Access to rehabilitation and support groups is not only important for the individual concerned but also for their wider network such as their family and friends who may be required to care for them.
How you can support a friend or loved one who has sustained a brain injury
While some brain injuries may lead to a physical disability, this is not always the case and so it can be hard to understand the impact a brain injury has on a person, particularly as you may not be able to see the disability. It may be difficult at times with their behavioural changes, but it is important to continue to provide support for the person so they can feel positive about their new life and feel there is some degree of consistency and continuity.
There are a number of different approaches you can adopt to help the person in your life adjust, including:
Be flexible and accommodating to any daily mood changes.
Encourage them to seek support from local groups or their GP.
Offer support when they need it. It's important not to assume that they can't be independent and offer to help with too much, but letting them know you're there will help them adapt over time. They may need assistance with food shopping, childcare, administration etc.
Consider how outings with them could be done to accommodate them, for example going to quieter locations, fitting in to their schedule of when they feel at their best during the day and taking into consideration any medication they're on could impact their diet.
"While the findings from the report highlight the challenges the pandemic has raised, there are also positive findings showing that local communities have rallied around those in need with 27% reporting a positive change in their relationship with their neighbours," concludes Dan. "Being able to have this support is encouraging; however it cannot replace the professional support provided by rehabilitation services. All brain injuries are different and will impact different aspects of people's lives, from cognitive functions to social skills, which is why we are supporting Action for Brain Injury Week once again this year to help raise awareness as to the importance of ensuring those affected have the appropriate physical, psychological and social support."
If you or a loved one has sustained a traumatic brain injury, you can contact Dan Thompson or a member of the Personal Injury team on 0800 91 92 30 or email injuryteamenquiry@warnergoodman.co.uk.
This is for information purposes only and is no substitute for, and should not be interpreted as, legal advice. All content was correct at the time of publishing and we cannot be held responsible for any changes that may invalidate this article.
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So I added La Campanella Nu Rave to music park (a song).
So I just want to start doing some Model imports I wanted to do in the past (by posting requests).
I'm very new to modding, but I have gotten CTGP up and running just fine.
I've changed so many of the icons in the .


The wisdom from more than three decades as a lawyer.
The vision of a better way to resolve disputes.
mediation/alternative dispute resolution (ADR) practice.
as a litigator, make him an effective mediator.
William Dowling focuses his practice on mediation and alternative dispute resolution.
He has extensive experience representing individuals and businesses in state and federal courts.
Over his years in legal practice, William Dowling became a true believer in alternative dispute resolution, combining his desire to find fair resolution of disputes with his dispassionate eye for the facts of a case.
Here you'll find valuable resources and links related to alternative dispute resolution.


We short change our children year after year as we funnel more money into for-profit charter schools and a failed system of teaching to the test. We must commit to caring for our children by investing in our public schools and teachers.
As a mental health professional, parent, and breast cancer survivor I know the importance of affordable and accessible healthcare. I will fight for healthcare that meets the needs of all families, including the particular needs of our veterans and military families here in Jacksonville.
I'm proud to have been endorsed by Florida's police and firefighters, and I understand how important it is to keep our neighborhoods healthy and safe.
Help Tracye create safety and prosperity for all families in Florida.


If our classes are canceled or delayed due to bad weather, we will post an announcement on this blog – ESL Blogs Central.
If Wake Tech Community College (WTCC) is closed, ESL classes will be cancelled at ALL locations.
If WCPSS is delayed for 1 hour, GUMC is delayed 1 hour.
If WCPSS is delayed for 1 hour, WPUM is delayed for 1 hour.
To find out about closings and delays for Wake Tech, listen to the Wake Tech switchboard recording at (919) 866-5500 OR read the announcement on the Wake Tech website: www.waketech.edu.
The college also shares announcements with the media. To be sure that the information is correct, check weather closing announcements on two or more stations.


text:
Despite the habitat suitability, not a single grizzly is known to be currently living in the American chunk of the North Cascades. (Photo: GomezDavid/iStock)
Adventure Environment
Why Did the DOI Kill the North Cascades Grizzly Plan?
A plan to bring some 200 bears to Washington's North Cascades was reportedly stopped by the Department of the Interior, jeopardizing the species' recovery.
Jake Bullinger
Outside's long reads email newsletter features our strongest writing, most ambitious reporting, and award-winning storytelling about the outdoors. Sign up today.
Getting to the lower 48's second-largest swath of prime grizzly bear habitat takes less than an hour by car from Seattle. The North Cascades Ecosystem begins at Interstate 90 and stretches north into British Columbia, covering 9,800 square miles—600 more than grizzlies have around Yellowstone National Park. Yet the odds of seeing a grizzly here are essentially zero.
Hunters in the 19th century shot thousands of the bears, as they did throughout the United States, driving them to near-extinction. But recently there has been solid action to reintroduce grizzlies into the North Cascades. Last January, the National Park Service and U.S. Fish and Wildlife Service released a draft plan to build a population of 200 bears here over the next 25 to 100 years, a move that could diversify the gene pool in case something devastated the species in the Rockies. The federal government had already poured money into a public relations campaign to educate locals. More than 127,000 comments had been made and were being reviewed. Then—without reason or warning—the recovery process came to a halt near the end of December.
Karen Taylor-Goodrich, superintendent of North Cascades National Park, said the Department of the Interior (DOI) ordered her team to stop all work on the North Cascades grizzly environmental impact statement, the first of many steps toward reintroducing the bears. "We're in year three of the process," Taylor-Goodrich said, according to the Missoulian. She and her team were offered no explanation. The DOI, in fact, has yet to say why it has seemingly abandoned the North Cascades grizzly program—DOI spokesperson Heather Swift told Outside that Secretary Ryan Zinke did not make the call to end the program, and when Outside asked if Zinke was even aware of the decision, Swift did not respond.
The North Cascades region is a rugged place, with remote terrain. It is fairly road-free and loaded with plants, berries, fish, and game that the omnivorous grizzlies can dine on, which would help keep them away from cattle and orchards. Fish and Wildlife identified the area as a potential grizzly recovery zone in 1993, due in large part to its size. "There are not many places in the lower 48 that you can even think about recovering bears," says Bill Gaines, a former Forest Service biologist who worked on the North Cascades recovery plan. "And then to have 10,000 square miles of public land, and something on the order of 40 percent be a national park or wilderness—that's a pretty good chunk of wild country."
Despite the habitat suitability, not a single grizzly is known to be currently living in the U.S. chunk of the range. An estimated six bears live in the Canadian section—far too few to push a meaningful population of breeding bears south. Without bringing in outside bears, biologists have concluded, local extinction of grizzlies is a major threat.
As has been the case in other recovery zones in Montana, Wyoming, and Idaho, the public didn't immediately jump on board. "It's been a challenge," says Jack Oelfke, who coordinates Park Service workers involved in the North Cascades grizzly recovery (Oelfke spoke with Outside about the program before the DOI decision, and the Park Service has since declined to officially comment). "There are lots of people in Washington who are pretty strong conservationists. But when you bring up grizzly bears, the prospect that their favorite hiking trail might now have grizzlies makes them pause."
To help win the war of public opinion, Fish and Wildlife and the Park Service began a three-year public education bonanza, a method successfully deployed in Montana, where the Northern Continental Divide Ecosystem bear population has swelled beyond 900. Bear managers created educational websites and held public meetings—which drew hundreds of attendees—to answer questions from hikers, hunters, loggers, ranchers, and farmers about the bears.
Without bringing in outside bears, biologists have concluded, local extinction of grizzlies is a major threat.
To further lessen concerns, the feds and researchers I spoke with said any bears brought to the North Cascades likely would be designated an experimental population under the Endangered Species Act. This designation, which was used when wolves were returned to Yellowstone, allows wildlife officials more leeway to relocate or, in extreme instances, kill troublesome animals. It's a move used primarily to gin up public support by assuring, for example, local apple farmers and loggers that they need not worry about their operations being shut down by a grizzly on their property.
The result of these efforts appears to be strong public support. The majority of public comments submitted, reviewers told me, were in favor of relocating bears to the North Cascades, and a 2016 poll suggested overwhelming support among Washington voters.
Critics, of course, remain, and have celebrated the stop-work order. Jim DeTro, a commissioner in neighboring Okanogan County, told the Capital Press, "Yes, ranchers in the Okanogan will be happy, but the opposition had bipartisan support. Even hikers and people on the green side said the North Cascades was no place for this."
The DOI's decision creates a murky future for grizzlies in the North Cascades. Taylor-Goodrich told a panel of grizzly experts last month that communication has stopped with Canadian partners, and Oelfke, the Park Service coordinator, told the Yakima Herald that no timetable has been issued for work to resume. NPS officials declined to comment, and Swift, the DOI's spokesperson, said she couldn't confirm whether the stop-work order had even been issued. Swift would only say that Zinke hadn't personally made the decision. "It sounds like from press reports that it was stopped," Swift wrote to Outside an email, "but if it was stopped it wasn't because the Secretary directed them to."
"[What is] frustrating is that the many years of science, public education, and significant taxpayer dollars that have gone into grizzly bear recovery in our region are apparently not being taken seriously by this administration," Chase Gunnell, spokesperson for Conservation Northwest, said in a statement.
These decisions are shadowed by uncertainty of how climate change will affect grizzly bears. Critical food sources in the Rockies, such as cutworm moths and whitebark pine seeds, are particularly threatened by warming temperatures, and scientists are uncertain how grizzly populations will respond. It's for this reason that North Cascades researchers stressed the importance of another population to the survival of the species.
Delaying action isn't simply an inconvenience. Had the environmental impact study proceeded, a final document would have been released sometime this year, and a decision would probably have been made in mid- to late 2018. Even at this pace, implementation wouldn't have begun for years. Meanwhile, the North Cascades grizzly population teeters on extinction as the Yellowstone and Northern Continental Divide populations are scheduled, and expected, to be removed from the endangered species list.
"Biologically, it's never a good idea to have just one or two small, isolated populations," Oelfke says. "If you've got at least one other population in the mix in the lower 48, that's a long-term benefit to the species."
It may have had wide support and been good for grizzlies. But for some reason the DOI didn't think so. They just won't say why.
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Lead Photo: GomezDavid/iStock
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Categories Webshop CDs Blues & Roots Acoustic Blues Dave Goodman & Steve Baker - The Wine Dark Sea
Dave Goodman & Steve Baker - The Wine Dark Sea
Product no.: 319.1478.2
Sound Samples
Click on the graphic to read the CD's booklet:
Master guitarist, composer and singer Dave Goodman teams up with harmonica maestro Steve Baker to create a heady mix of country rock, acoustic funk, blues and folk which exudes a powerful identity all of its own and yet defies stylistic definition. Goodman's sophisticated and exceptionally versatile work on both acoustic and electric guitar and his inspired songwriting meet their perfect foil with Baker's tasteful, arrestingly original harmonica parts. The combination has clearly born fruit and on "The Wine Dark Sea", both artists deliver what is arguably their finest work to date. It is rare that this level of instrumental expertise is combined with great songs, great vocals and state of the art production, but Goodman and Baker have clearly succeeded in pulling this off with a vengeance.
Both protagonists have long enjoyed a fruitful association with Acoustic Music Records. Dave Goodman's last solo CD "Side Of The Road" received excellent reviews and cemented his burgeoning reputation as a virtuoso instrumentalist and highly talented songwriter. He is also a regular contributor to Acoustic Player and works closely with Peter Finger on numerous workshops and concert appearances. Steve Baker has been on AMR since the mid 1990s, releasing four highly acclaimed CDs with the late great singer/guitarist Chris Jones as well as "King Kazoo" with Dick Bird. On "The Wine Dark Sea", Goodman & Baker are brilliantly supported by Martin Röttger on drums and cajon and Oliver Spanuth on drums. The CD also includes guest appearances by Big Daddy Wilson, Hanna Lunnon and Kolja Heins.
With "The Wine Dark Sea", Dave Goodman and Steve Baker have created a work which transcends genre while remaining inherently consistent from beginning to end. Beautiful production and great songs, masterfully orchestrated, vocally and lyrically totally convincing.
Dave Goodman: guitars, banjo, bass, vocals
Steve Baker: harmonica, backing vocals
Martin Röttger: cajon, drums
Oliver Spanuth: drums
Big Daddy Wilson: vocals, backing vocals
Hannah Lunnon: backing vocals
Kolja Heins: hand claps
"...one hell of a hot disk. It contains 14 mostly excellent (sometimes good-as-it-gets) songs in a style that's strongly reminiscent of Ry Cooder, Little Feat, and Bonnie Raitt, performed by a small group of topnotch musicians whose respect for groove is obvious. Anyone who likes this style is going to end up playing this record frequently. And if, like me, you always thought a little more world-class harmonica would make any of the above-named bands sound even better, well, this record is going to make you very happy...."
Richard Hunter, hunterharp.com, as seen as on 2012-11-10.
Complete review: http://www.hunterharp.com/record-review-the-wine-dark-sea-dave-goodman-steve-baker/
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Dave Goodman - Side Of The Road
Steve Baker / Chris Jones - Smoke And Noise
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Browse these categories as well: Acoustic Blues, Steve Baker, Dave Goodman


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How healthcare market research agencies should tackle GDPR ?
Within the framework of the worldwide data protection day (28th January), a healthcare market research agency highly concerned by the compliance toward the GDPR has questioned itself on the effects of this new regulation on Market Research agencies. As part of this reflection, Pascal Thisse expert in Data Protection for 8 years and CEO of "Data Privacy Professionals" has kindly answered their questions.
GDPR (General Data Protection Regulation) will apply to all companies from May 25 2018. My first question is what are the main challenges, in your view, for healthcare market research companies in the context of compliance with GDPR?
Before we talk about challenges, we have to think about the characteristics of those healthcare market research companies. I can see 4 different characteristics.
So we have four characteristics.
The first challenge considering these four characteristics is that a Data Protection Officer (DPO) is mandatory.
This is an obligation then. Those companies must have a DPO.
Yes, they must have a DPO. The DPO is mandatory in this case. It is relatively clear.
The second challenge is that GDPR will be effective from 25 May 2018 onwards. That leaves us with 4 months. They must launch a data privacy program, within a relatively short period of time, and in line with regulations, including GDPR.
Therefore, this is the second challenge, i.e. the timeframe is relatively short and a substantial effort is required for launching a data privacy program. They will need to do that quickly.
Are we talking about companies, or company profiles, that present an increased, or at least a slightly more important risk than other types of companies?
Yes. There is no doubt in that regard. The first risk, is the financial risk to start with. In case of non-compliance, the fine might be up to 4% of the overall company's turnover or 20 million Euros (whichever is higher). With such companies, the sanction might be made public by the data privacy authority. That would severely damage the company's reputation.
Another point is the operational risk. The people involved (data subject) can more easily make requests such as access (right of access), rectification (right to rectifications), personal data erasure (right to erasure / right to be forgotten) from May 2018. Therefore, data subject requests could speed up from this date.
For this, the companies will need to have the adequate resources, in terms of IT and/or human resources, in order to respond to requests.
To conclude, the financial risk is related to the operational risk. Is this something that will be specific to market research? Yes and no… It is specific in a sense that market research companies process sensitive data. A non-conformity could definitively damage their reputation, namely in case of "data breach". I think that is the main risk.
Based on the data gathered, we talk about healthcare data, and companies communications with healthcare professionals, sometimes with patients, and regarding diseases that are "sensitive" and with sensitive characteristics… Is this also an additional risk compared with another type of activity?
Regarding the sensitive data, the regulator has not differentiated between healthcare data, that I would call benign, and something more important. By benign, I mean something like taking a very common medication like Doliprane. There might be more important things like someone suffering from Multiple Sclerosis or a rare disease, etc. Such differences are not explicitly made in the regulation when it comes to healthcare data.
Perhaps it is worth considering, in terms of taxonomy or typology/classification of data, that companies make the distinction.
Which highlights the importance of the DPO in the company… or the DPO's role rather.
We have listed the different challenges and we mentioned the risks for these companies – what would be the first piece of advice that you would give personally to these market research companies specialised in healthcare, in order to "live through" the GDPR properly?
The first piece of advice is that, given the risks we have just mentioned, it is clearly necessary to seek help from consultants specialised in data privacy. Data protection is not something we can improvise. It also covers different aspects. There is a legal aspect; a technical/technological aspect (including the knowledge of the IT system); and an operational aspect by embedding data privacy principles/processes within the organisation. They need to have the relevant people able to understand the data privacy concepts.
The second piece of advice is that they should not think that 25 May 2018 is the end of the story concerning their involvement regarding "data privacy" matters. It is the opposite actually. This is the beginning of the story regarding "data privacy". They must keep that in mind. If May 25 2018 remains an important deadline, it should be viewed as the beginning of the new "data privacy" paradigm and associated compliance.
In a sense what it is going to change… the behaviours, the way of working within the company, right?
Absolutely. It means that employees might have to change their attitude regarding the way they process personal data. Therefore, the overall environment is going to change. They really have to understand this notion of GDPR as something that will remain with the company all the time. It is going to be a new challenge for the company, but it will remain this way forever. It is not something that will stop. It will remain in place.
Do you have other comments or pieces of advice that we have not covered, and that could be added and be of interest to all market research companies?
Perhaps a last piece of advice: personal data is clearly an intangible asset of a company. It must be seen as such. They must capitalise on this, while complying with regulations, especially regarding GDPR. The right balance needs to be found. That is why a DPO is needed in order to find the right balance regarding capitalising on personal data and using them wisely, whilst as the same time making sure the company respects regulations.