The answer is probably not as clear as it might seem. While, geographically, that corner inside the living room might appear to maximize sense, its crucial that you consider the degree of distraction you may well be facing in the foreseeable future. Televisions, youngsters, telephones, and animals can almost all come since unexpected distractions in your productivity. Pick a space together with minimal targeted traffic, minimal utilize, and minimal usage of distractions.
Furthermore, its important in order to separate perform life from your home life- the opportunity to shut any door and also "leave work" is totally crucial regarding reducing anxiety levels and also reducing the chance of "burn out". Perhaps a great unused dining area, or formal family area might be a better alternative than employing a spare room.
Your home business office should compliment the others of your property. If your property has a normal design with a lot of warm tones- then stick to that. Your home business office space must seamlessly blend in to the design of your property, not yell "cold, soul-less cubicle". You also desire to avoid clashing layout themes- you could have that fantastic desk the mother-in-law provided you- yet if that clashes with all the flow with the room, it could be worth the excess cost in order to avoid those system hiccups. All things considered, you want your property office to offer a perception of ease and comfort and ease- not be described as a stark shock for the senses.
It might appear like any superfluous or perhaps excessive expense to include built- inside organization or perhaps storage in to a home-office if the option to perform to a nearby store and buy a workplace or corner (together with assembly necessary) is obviously there, but incorporating furniture with a home could cause clutter- and in terms of home business office, clutter could be the enemy. Consult with your artist about including built-in shelving, cabinets, and also drawers directly into your area. This will increase just how seamlessly your property office area blends into your property, but may also avoid potential problems with purchasing organizational equipment which inevitably enhance the problem as opposed to solve that.
Likely just about the most crucial components of any residence office- the right office chair needs to be of highest priority. In terms of picking the right office chair- free no expenditure. You'll become spending a massive portion of energy sitting because chair, so ensure it can be as comfortable and also functional as you can.
Help make your area uniquely "you". Forget the muted, office beige (except if that's just what works to suit your needs) and also paint or perhaps accent the space any color you adore. We've previously had several discussion about how precisely color make a difference your disposition, and in terms of productivity at the office place- everybody knows how significantly mood make a difference productivity. Set the space around be soothing, permanent, useful, comfortable, which is tailored in your needs and also wants. Don't forget to become daring- provided that the area is useful, then who's to state you can not design the desk undertake a built-in munch bowl, perch to your kitty to be able to sleep close to you, and even something since radical being a place that will put a spot of turf underneath so if you are working it is possible to take away from your shoes or boots and feel the grass under the feet? If you're working at home, you hold the distinct flexibility to chuck aside convention in terms of design- put it to use!
In a ideal situation- we could all develop our residence offices to forget the skyline individuals city, or perhaps overlook any white mud beach, but the reality is that we need to use that which you can. Giving oneself something a lot more interesting to consider during people brief occasions when looking far from a computer is likely to make you convenient. A windowpane is ideal- but a good picture or perhaps painting you truly enjoy provides those emotional breaks which can be so crucial that you a productive work environment. No a single likes observing a bare wall, so while many of us can't become afforded the right view, treat yourself to the finest of everything you can.
Give yourself a lot of light. Needless to say natural mild is desired, but the daylight hours are limited- so be sure that your a workplace provides enough, bright light using a good shade. You will more than likely need a lot more light as compared to you'd anticipate- thus adding further light fixtures can be an important thought. Increased mild will lessen eye strain preventing those bothersome headaches. Make sure you choose any bulb that gives light in the spectrum in which works to suit your needs! Pale, crisp mild sitting better the glowing blue side with the spectrum usually offers extra energy and also produces enough light. Stick about 900 Lumens bare minimum (according to space) and be sure that your light source is in quick access from any seated place.
We notice this phrase a lot- but if you are setting up your property office layout, make that priority. You can save so much hard work while steering clear of serious long-term issues by ensuring that your home business office space can be as ergonomic as you can. We put in hours per day at our own desks, and scientific studies show us a growing number of how unfavorable being seated inside the improper healthy posture can wreak havoc around the body. Guard yourself, the safety, ease and comfort, and well-being: ensure you do what you may can to produce your area friendly in your body.
Consider including office crops into your property office layout. Adding any plant or perhaps two in your office space may have more of your impact than you may be thinking. Studies demonstrate that possessing live greenery in the work area can improve air quality, make the room convenient, reduce anxiety, and boost productivity. A plant can be a welcomed and also reasonable distraction inside the moments you decide to use care because of it by tearing or pruning- and also besides, they will look great!
Usually over seemed and unjustly thus. Nothing can cause more of your eye sore in the home office when compared to a nest regarding cables cluttering any desk or perhaps floor. Velcro cable tv ties are usually your good friend! Talk along with your designer concerning incorporating approaches to hide in pretty bad shape of cabling. Make sure that your space is defined up for almost any connection you may want, including satisfactory electrical retailers. Make positive to abandon your products layout ready to accept be altered- there is a constant know when you will end up getting several new little bit of office technical, or once you should remove an item of equipment. In the event the cables are usually hard to gain access to, or difficult to incorporate to- you'll find yourself at rectangular one using a nest regarding cables. Increasing simple access and also efficiency will be key!


text:
Readout of the Vice President's Call with Ukrainian Prime Minister Arseniy Yatsenyuk
Vice President Joe Biden spoke with Ukrainian Prime Minister Arseniy Yatsenyuk today to congratulate him on Ukraine's ratification of its Association Agreement with the European Union. The Vice President also congratulated the Prime Minister on the passage of laws on Amnesty and Special Status for parts of the Ukrainian regions of Donetsk and Luhansk, in keeping with the ceasefire protocol agreed to by Russia and Ukraine in Minsk on September 5, 2014. Finally, the Vice President and Prime Minister agreed that Russia and its separatist proxies now needed to immediately implement in full the twelve points of the Minsk Agreement, including the removal of all Russian troops from Ukraine and the creation of a security area in the border regions of Ukraine and the Russian Federation.

redpajama_set_name: RedPajamaCommonCrawl


text:
El Moviment per una Geòrgia Unida (georgià მოძრაობა ერთიანი საქართველოსთვის, Modsraoba Ertiani Sakartvelostvis, MES) és un partit polític de Geòrgia, fundat el 27 de setembre de 2007 per l'ex ministre de Defensa, Irakli Okruashvili. S'oposa a la tendència de l'actual president de Geòrgia, Mikheil Sakaixvili, vers l'autoritarisme. Okruashvili va ser detingut el 28 de setembre de 2007, cosa que va donar lloc a manifestacions contra el govern.

El partit va ser inaugurat oficialment el 15 de desembre de 2007 amb Gia Tortladze, membre del Parlament de Geòrgia, com el seu president, mentre que Irakli Okruashvili, qui es troba detingut a Alemanya, va ser escollit "president honorari".

El Moviment per una Geòrgia Unida va formar part de la coalició de nou partits de l'oposició coneguda com a "Consell Nacional", va donar suport Levan Gachechiladze com a candidat a les eleccions presidencials georgianes de 2008.

Enllaços externs
 Creació del partit a civil.ge

Partits polítics de Geòrgia

redpajama_set_name: RedPajamaWikipedia


If you have any questions about our range, dont hesitate to get in contact with our friendly team.
Remember to factor in extra costs like taxes and shipping or delivery.
Innerspring sets from 1099 in queen.
In the retail world, this is known as price eon energy discount anchoring, because retailers try to anchor a perception of value with a high price, making discounts seem larger.They have the lowest customer satisfaction rates of all the mattresses, but tend to be cheaper.Below, this years Black Friday mattress deals are sorted into categories by price.Coils 1,048 Mattress Firm 100 days / 10 years Serta iComfort Blue Fusion 100 Hybrid Firm Queen Mattress 12 profile, firm?" ge MF,?" foam 1008 pocket coils 1099 Mattress Firm 100 days / 10 years Serta Vantage Firm II Set?Where you need more cushion, like your shoulders, the foam hexagons are farther apart.Especially since its being offered at a discount with up to two free pillows over the holiday weekend.Some retailers will inflate their original prices to make sale discounts.Labor Day mattress sales are a perfect time to save on a new bed, but who wants to spend hours scanning ads and researching beds on a holiday weekend?On the other hand?Here are a few of the most common factors consumers find important, according to research by Bed Times Magazine, which play a big role in our analysis: Comfort 89, back support 81, no sinking 73 No noise 63 Stays cool 60 Contours to body.Plush feel, pocketed coil design, returns: 60 days, warranty: 10 Years 2,649.Most memory foam mattress are made from foam that comes from 100 petroleum (crude oil).Here are our 3 highest recommendations from this years Labor Day memory foam deals.So dont buy one without doing some research first.Sale events can be a great way to find your dream bed for less.And find out up front whether you have to pay a fee to make a return.
Mattress Firm tends to do this a lot.
Hologenix, LLC, the maker of Celliant, states that Celliant safely converts body heat to infrared energy.Memory Foam Discounts Memory foam beds have exploded in popularity in recent years.Up to 200 instant savings on select iComfort Mattresses, on the Blue Max 10 models Up to 500 off select adjustable bases or a free boxspring on select Queen sets and Split King sets m Tempurpedic also sells direct online as well as through their.Its always a good idea to check the finer details, as most warranties are prorated and some retailers have additional limitations on returns.A better price is only worth it if the end product delivers a comfortable sleep.These special mattress covers safely turn body heat into infrared energy.
How to Find Killer Black Friday and Cyber Monday Mattress Deals Not all Black Friday deals are going to be winners for you.
Read on to compare the 2017 Labor Day mattress deals and get tips for picking the best bed.
Here is a short list of some things that you should be mindful of while bargain hunting.


text:
52 million people affected worldwide	1 2
The 2010 Global Burden of Disease study estimated that there were 52 million people worldwide with ASD. The World Health Organization estimates there is about one in 160 children worldwide living with some form of autism spectrum disorder. Globally, autistic disorders account for more than 58 DALYs per 100,000, accounting for a substantial health loss across the life span.
Current Treatments	1 2
There are currently no FDA-approved pharmacological treatments for autistic adults with social anxiety, and conventional anti-anxiety medications lack clinical effectiveness in this population. Ways to minimize symptoms do exist and include behavioural management therapy, cognitive behavioural therapy and occupational therapy, to name a few.
Psychedelic research currently is in Phase IIb
Research using psychedelic's to treat autism spectrum disorders is in its infancy. Nonetheless, a recent double-blind placebo-controlled pilot study found that MDMA-assisted therapy reduced social anxiety in autistic adults and these effects persisted for six months. With some companies in the psychedelic space focusing on autism spectrum disorders, it won't be long until new research emerges,
Autism specturm disorder (ASD) is a complex developmental condition that involves persistent challenges in social interaction, speech and non-verbal communication, and restircted/reptitive behaviours. About 1 in 160 children worldwide have ASD
The exact causes remanin unknown and there is currently no one standard treatment for ASD. A range of therapies are often used based on the needs of the individual
Alicia Danforth and Charles Grob are leading the research into using psychedelics to treat ASD. While the clinical research is scarce, testimonals from members of Autisitc Psychedelic Community who use psychedelics are very positive
What is autism spectrum disorder?
Autism spectrum disorder (ASD) is a complex developmental condition that involves persistent challenges in social interaction, speech and nonverbal communication, and restricted/repetitive behaviours. The effects of ASD and the severity of symptoms are different in each person [1].
There are four major types of ASD; autistic disorder, Asperger's, childhood disintegrative disorder, or pervasive developmental disorder not otherwise specified (PDD-NOS). Now, under the criteria set out in the DSM-V, these conditions are now all called ASD [2].
Moreover, although autism is often not diagnosed until much later, under the DSM-V criteria, individuals with ASD must show symptoms from early childhood, even if those symptoms are not recognized until later in their life [2].
People living with ASD can have significant social, communication and behavioural challenges. For example, a person with ASD may not be fond of changes to their daily routine or often repeat certain behaviours. Other behaviours can include having trouble in expressing oneself and difficulties in relating to others [3].
The World Health Organization estimates about 1 in 160 children worldwide live with some form of an ASD [4].
Globally, autistic disorders account for more than 58 DALYs (disability-adjusted life years) per 100,000, the common metric used to assess the overall burden of a given disease. Thus, ASDs account for a substantial health loss across the life span [5].
The exact causes of ASD remain speculative, with both environmental and genetic factors thought to be involved.
Diagnosis & Conventional Treatments
Diagnosing ASD can be difficult given the wide range of symptoms and there are currently no medical tests, such as a blood test, to aid in diagnosis. Paediatricians look for signs of ASD during a child's general visits at 18- and 24-months, even if they don't appear to have any symptoms. At these visits, parents are asked questions regarding their child's development and behaviour [6].
Screening tools do exist to help medical professionals diagnose autism. The Autism Diagnostic Observation Schedule (ADOS) and the Autism Diagnostic Interview-Revised (ADI-R) are considered the gold standard for diagnosing ASD [7].
At present, there is currently no one standard treatment for ASD. However, ways to minimize symptoms do exist.
Common interventions include behavioural management therapy, cognitive behavioural therapy (CBT), occupational therapy, speech-language therapy, and physical therapy to name a few. Early diagnosis and intervention, such as during preschool or before, are more likely to have major positive effects on symptoms and later skills [8].
There are currently no FDA-approved pharmacological treatments for autistic adults with social anxiety, and conventional anti-anxiety medications lack clinical effectiveness in this population [9].
Psychedelics and Autism
Research into the potential use of psychedelics to treat autism initially began in the 1960s and continued until the 1970s when psychedelics became Schedule I substances.
Alfred Freedman and colleagues are just one group of several that treated autistic children with psychedelics during the first era of research. In their study, Freedman and colleagues noticed significant psychological change after administering 50-200ug of LSD to their sample group (n=12) [10].
A more recent review of the literature from the many research groups of this era using LSD in the treatment of children with autism highlights the controversial nature and many methodological flaws with this research.
While issues regarding consent may not have to the fore at the time, conducting such experiments on children raises ethical concerns by today's standards. Additionally, many of the findings suffered from major methodological flaws, so much so, that Sigafoos and colleagues conclude by stating the research from this era is of little relevance to modern research [11].
Nevertheless, the psychedelic renaissance we are experiencing has sparked a renewed interest in the potential of psychedelics to treat ASD.
Modern Research into Psychedelics and Autism
While research into the effects psychedelics have on ASD is sparse when compared to other mental disorders like depression, some trials have taken place.
It should be noted that modern research is currently only looking at minimizing the negative effects of ASD, if we speak of treatment, it is this perspective, not 'curing' ASD that we're talking about.
Working from the Harbor-UCLA Medical Center, Alicia Danforth and Charles Grob are leading the way into realizing the potential of psychedelics to treat ASD.
Sponsored by MAPS, Danforth and Grob published an initial review in 2016 proposing a new treatment model for social anxiety in autistic adults. The authors discuss the ability of MDMA to catalyze shifts toward openness and introspection and, given that MDMA-assisted therapy does not require ongoing administration to achieve lasting benefits, it could be an advantageous treatment strategy.
The aforementioned paper laid the foundations for a pilot study in 2018 in which MDMA-assisted psychotherapy was utilized to treat autistic adults.
Utilizing the Leibowitz Social Anxiety Scale (LSAS), the double-blind, placebo-controlled, randomized pilot study (n=12) found a significant reduction in social anxiety (d=1.4) after MDMA-assisted psychotherapy (75-125mg, 2 sessions). The observed reduction in social anxiety was maintained 6 months later.
Furthermore, in 2019 Danforth analysed the subjective experiences autistic adults reported after they took MDMA in nonclinical settings by conducting a retrospective survey (n=100) and qualitative interviews (n=24).
Findings from the study indicate that MDMA-assisted psychotherapy may be an effective catalyst in autistic adults for intra- and interpersonal change as well as participants reporting accounts of lasting transformation and healing from conditions such as trauma and social anxiety that are common in autistic populations.
The findings from the recent Phase III trial from MAPS using MDMA to treat PTSD may also have positive implications for using MDMA to treat social anxiety in people with ASD. PTSD and social anxiety are often experienced comorbidly and therefore, it could be possible that the positive results from this trial could be replicated in autistic adults with social anxiety. Nevertheless, controlled clinical trials will be needed to test this hypothesis.
How might psychedelic drugs treat ASD?
The exact mechanism by which psychedelic drugs can alleviate symptoms of ASD remains unknown. It has been postulated that classical psychedelics and entactogens, like MDMA, influence social processing through agonism at the 5-H2TA receptor in the brain which increases prosocial behaviour [12].
Additionally, the Default Mode Network (DMN) has been implicated in ASD as numerous neuroimaging studies have pointed out [13].
Given that it is hypothesized that psychedelics have the ability to alter the DMN once consumed, it could be possible that psychedelics mediate their therapeutic effects in ASD by altering the DMN. Further research is needed in order to elucidate the exact mechanisms by which psychedelics act in the brain of those with ASD.
Psychedelic Industry and ASD
Within the psychedelic industry, Pilz BioScience appears to be the only company specifically focusing on utilizing psychedelics to treat ASD.
A subsidiary of the Vancouver based Nova Mentis Life Sciences Corp, Pilz BioScience is attempting to harness the potential of psilocybin to target the association between autism and neuroinflammation in the hope of optimizing cellular function as well as modifying cognitive perception.
Using their synthetic derivatives of psilocybin and psilocin to treat ASD, Pilz hopes to commence Phase I clinical trials in 2022. As further research emerges, perhaps so too will more companies and research groups targeting ASD.
Although data from clinical trials is necessary and invaluable with regards to informing both medical professionals and regulatory bodies of the safety and efficacy of psychedelic drugs, so too are the accounts of people living with mental disorders.
In 2019, Aaron Orsini who lives with ASD published his book "Autism on Acid: How LSD Helped Me Understand, Navigate, Alter and Appreciate my Autistic Perceptions" in which he gives an account of his wholly positive experiences as being autistic experimenting with LSD.
Moreover, there exists an entire community of people with autism experimenting with psychedelics who offer support to others in similar positions. The Autistic Psychedelic Community (APC) is a collaborative co-learning community exploring the intersection of psychedelics and neurodivergence.
The APC recently published a book "Autistic Psychedelic – The Self-Reported Benefits & Challenges of Experiencing LSD, MDMA, Psilocybin, & Other Psychedelics as Told by Neurodivergent Adults Navigating ADHD, Alexithymia, Anxiety, Asperger's, Autism, Depression, OCD, PTSD & Other Conditions." Their first-hand accounts offer perspective on how people living with autism are benefiting from self-medicating with psychedelics.
The APC is currently working in collaboration with the research team at University College London on a survey study exploring the benefits and challenges of naturalistic psychedelic use in people with ASD. If you are a self-diagnosed and/or clinically diagnosed autistic adult who has experience with using psychedelic's, you can take part in the survey here.
Based on preliminary research findings and the many positive anecdotal reports from members of the Autistic Psychedelic Community, psychedelics do show promise in helping people with ASD manage their symptoms. Ultimately, clinical trials will be needed to explore this potential therapeutic effect of psychedelic's before they become a viable treatment option.
1. American Psychiatric Association. (2018). What Is Autism Spectrum Disorder? American Psychiatric Association. https://www.psychiatry.org/patients-families/autism/what-is-autism-spectrum-disorder
2. American Psychiatric Association. (2013). Autism Spectrum Disorder – Diagnostic and statistical manual of mental disorders (5th ed.). American Psychiatric Association. https://www.psychiatry.org/File%20Library/Psychiatrists/Practice/DSM/APA_DSM-5-Autism-Spectrum-Disorder.pdf
3. CDC. (2020). What is Autism Spectrum Disorder? Centers for Disease Control. https://www.cdc.gov/ncbddd/autism/facts.html
4. World Health Organization. (2021). Autism spectrum disorders. Geneva: World Health Organization. https://www.who.int/news-room/fact-sheets/detail/autism-spectrum-disorders
5. Baxter, A., Brugha, T., Erskine, H., Scheurer, R., Vos, T., & Scott, J. (2015). The epidemiology and global burden of autism spectrum disorders. Psychological Medicine, 601-13. doi: 10.1017/S003329171400172X
6. Alli, R. (2020). How Do Doctors Diagnose Autism? WebMD. https://www.webmd.com/brain/autism/how-do-doctors-diagnose-autism
7. McCarty, P., & Frye, R. (2020). Early Detection and Diagnosis of Autism Spectrum Disorder: Why Is It So Difficult? Seminars in Pediatric Neurology. https://doi.org/10.1016/j.spen.2020.100831
8. National Institutes of Health. (n.d). What are the treatments for autism? Bethesda: National Institutes of Health. https://www.nichd.nih.gov/health/topics/autism/conditioninfo/treatments
9. MAPS. (n.d). MDMA-Assisted Therapy for the Treatment of Social Anxiety in Autistic Adults. San Jose: Multidisciplinary Association for Psychedelic Studies. https://maps.org/research/mdma/anxiety/autism
10. Freedman, A., Ebin, E., & Wislon, E. (1962). Autistic Schizophrenic Children. An experiment in the use of d-lysergic acid diethylamide (LSD-25). Arch Gen Psychiatry. https://doi.org/10.1001/archpsyc.1962.01710210019003
11. Sigafoos, J., Green, V., Edrisinha, C., & Lancioni, G. (2007). Flashback to the 1960s: LSD in the treatment of autism. Developmental Neurorehabilitation, 75-81. https://doi.org/10.1080/13638490601106277
12. Preller, K., & Vollenweider, F. (2019). Modulation of Social Cognition via Hallucinogens and "Entactogens". Frontiers in Psychiatry, 881. https://doi.org/10.3389/fpsyt.2019.00881
13. Padmanabhan, A., Lynch, C., Schaer, M., & Menon, V. (2017). The Default Mode Network in Autism. Biological psychiatry. Cognitive neuroscience and neuroimaging, 476-486. https://doi.org/10.1016/j.bpsc.2017.04.004
These are the institutes, from companies to universities, who are working on Autism.
Pilz Bioscience
Pilz Bioscience aims to use psychedelics in the treatment of Autistic Spectrum Disorder (ADS), a neuroinflammatory condition. The company is fully owned by Nova Mentis.
Nova Mentis
Nova Mentis is a Canadian listed (CSE, FSE) company that holds two subsidiaries, Nova Mentis Biotech and Pilz BioSciences that investigate psychedelics as medicines for a variety of mental health indicators.
Autistic Psychedelic Community
The Autistic Psychedelic Community (APC) hosts a weekly (digital) meetup that supports learning about the intersection of ADS and psychedelics.
In October 2021, the Understanding Neuroplasticity Induced by Tryptamines (UNITY) Project was launched at University College London.
These are some of the best-known people, from researchers to entrepreneurs, working on Autism.
Charles Grob
Charles Grob is a Professor of Psychiatry & Biobehavioral Sciences and Pediatrics at UCLA. His work with MDMA was the first FDA approved Phase 1 study. He co-founded the Heffter Research Institute and is also affiliated with the Lundquist Institute for Biomedical Innovation.
Alicia Danforth
Alicia Danforth is a clinical psychologist who specializes in psychotherapy for autistic adults (private practice). Next to this she also works on several clinical studies and provides integration work.
Aaron Paul Orsini
Aaron Paul Orsini is the author of Autism on Acid and community organizer around Autism Spectrum Disorder (ASD) and psychedelics at the Autistic Psychedelic Community.
Linked Research Papers about Autism
Embracing Neurodiversity in Psychedelic Science: A Mixed-Methods Inquiry into the MDMA Experiences of Autistic Adults
Reduction in social anxiety after MDMA-assisted psychotherapy with autistic adults: a randomized, double-blind, placebo-controlled pilot study


Thinking of building a PC from scratch and on a budget?
Maybe you should consider a cardboard case like the one below?
Sounds odd, but when you think about it there are many things that you could fit a PC inside. All you need is an ATX PSU (Power Supply Unit) and a switch off an old power supply (ATX style only), or you could make your own Switch/Reset using momentary switches from Maplin or the like.
If you fancy creating your own ATX switch and reset button, it's easy check out this site.
Maybe if you have an old G4 lying about you could convert the innards into a PC!
Trying to increase your PageRank in Google? Maybe this is could help your site.
I've created a links page on my site (see link below) which you can add your URL, providing your website is of similar web development content it will be accepted pending human verification at a later date.
Before submission of your link you will be required to link to nikmakris.com. Your site will then be checked for the reciprocal link automatically and if it passes you will be added to nikmakris.com links page.
How will this help your site?
Google uses an algorithm called PageRank, which gauges the usefulness of your pages based on the amount of inbound links to your pages. Each page has it's own Page Rank.
When you link to a page on another site you are essentially "voting" for that site. The site you link to will gain a proportion of the PageRank of that page depending on the amount of links on that page and if that page has any Page Rank at all.
If the page you link to also links to you, you will receive a "vote" as well.
PageRank is a multiplier which when combined with good search engine optimised HTML will give you much higher rankings in Google. So the higher Page Rank you have the better.
An indication of your PageRank can be found out if you install the Google Toolbar with advanced features from www.toolbar.google.com, although this is only an indicator since PageRank is logarithmic.
Why study for a Cisco CCNA ?
CCNA - Cisco Certified Network Associate, is a certification for people looking to gain a high level of knowledge in networking and Cisco products.
It is also a prerequisite for other high level Cisco certifications, such as CCNP, CCIE.
There are two ways to train for this exam.
You can either buy a book and learn yourself, (I bought the book below which is very useful, and I read it cover to cover before taking the exam) this method is good, but you will miss out on practical experience unless you have a couple of Cisco routers lying about in your garage. You can buy Cisco simulators which you can practise on, but I didn't like these too much.
The other way is to check out your local colleges for evening classes or boot camps, which will aid your learning providing you with exposure to Cisco equipment and teachers knowledge.
The CCNA 640-607 is a 75 minute exam with a varying number of questions. This exam is fairly difficult and you need to know your stuff inside out!
The Cisco Networking Academy is an online learning resource which will guide you through the CCNA pathway, providing online assessment, training and hands-on labs.
Below is the Cisco Threaded Case Study (TCS) that I was involved with while studying for my CCNA.
A similar case study will need to be undertaken by you if you choose to study the Cisco Networking Academy.


In 1948 Cameron Argetsinger, a young law student and sports car enthusiast conceived an idea: to stage a European-style road race through the village of Watkins Glen, NY. Now, more than fifty years later, racing continues to thrive in Watkins Glen, the site now known worldwide as the birthplace of road racing in America.
Watkins Glen: The Street Years is the story of the first five years of racing in Watkins Glen, when the cars raced through the streets of the village. Told through personal accounts from the race's founder, through the stories of the drivers and residents of Watkins Glen and with a collection of race photographs and newsreel footage, Watkins Glen: The Street Years chronicles the excitement and adventure of one of the great stories of sports in America.


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– therapeutic schools for teens and therapeutic boarding schools for boys.
Seeking a Military Boarding School in Richmond, Virginia for a Son or Daughter?
Many parents search for military schools for troubled teens because they believe strong enough discipline will reform their wayward son or daughter. Military schools seem like an appropriate decision for troubled teens because they promise to generate responsible citizens. They instill respect, discipline, cooperation, and leadership in a structured environment: specifically what parents of a struggling teen wish to see.
For young people who merely lack discipline, the well-ordered surroundings and high expectations of a military school could be the right response to bring them into line. However, military schools are rarely willing to enroll a student with serious behavioral problems. Being a respected element of the educational system, these boarding schools require a particular level of performance and often will expel a teen for failing to comply. They also will not enroll a teenager who is unwilling to be there.
Is Your Teen in Richmond, Virginia Acting Out or Truly Struggling?
Military schools do not try to cope with the issues that may be triggering the undesirable behavior of a troubled teen. These schools dispense discipline but aren't equipped to provide therapy or treatment of any sort. Instead, parents wanting a military school for a troubled teen should take a detailed look at the teen's behavior in addition to their own motives for selecting a military program. For issues for example oppositional or defiant behavior, ADHD, depression, drug abuse, or destructive behavior, These schools are probably the more appropriate choice.
Although a normal military boarding school might not be the solution, alternative schools for troubled teens are available. Numerous therapeutic boarding schools use a military-based program such that the therapeutic environment also includes the physical conditioning and formal structure connected with a military school. Thus students reap the same citizenship and leadership benefits of a military school but in addition have access to the help they require for truly lasting change.
Any therapeutic boarding school that follows a military school format will incorporate the typical uniforms, formations, and rigidly ordered daily schedule. Physical conditioning through formal exercise and sports programs keep students active and fit. As with any program for troubled teens, professional counseling in individual and group settings is typically included. A therapeutic form of military school for troubled teens also emphasizes education so that teens distracted by other life issues have the opportunity catch up and improve their grades.
A therapeutic school for troubled teens can create a lasting impact when therapy is combined with the time-honored methods of a military environment. A lot of students at therapeutic boarding schools turn their lives around and go on to successful careers within the service and elsewhere. As always with a hurting child, parents should consider the teenager's needs and find a program with the right combination of discipline and care.
A therapeutic boarding school knows that you can be feeling hopeless, while your child seems uninterested in preparing for their own future. Military schools lack the tools to help with this, and once your child has begun to struggle, he or she often can't get caught up without help.
Students at therapeutic boarding schools are helped by a caring staff and given incentive for improvement. Increasing rewards and responsibilities are given as they make progress in the program and school. It is our goal that every young person that attends a therapeutic boarding school departs possessing the tools to rebuild family relationships and a strong future.
A therapeutic boarding school provides the solution. The academic programs of these schools are designed to work at the individual pace of the students. Their low teacher to student ratio means that your son will get all the guidance and hands-on assistance he needs to really grasp the subjects he battled with back home. Additionally, your son will finally get the chance to make up credits that he might have missed. The hole he has dug himself is not so deep as it seems.
If your child is troubled and you're searching for military schools in Richmond, Virginia, please consider one of the academies that we can tell you about.
Excerpt about military schools in Richmond, Virginia, used with permission from Wikipedia.
Should you need help finding therapeutic boarding schools, behavioral health treatment centers, troubled youth programs or educational consultants, please let us know. Teens we treat who are misbehaving could be struggling with mental or emotional issues like depression, ADHD, drug abuse, alcohol abuse, or an anxiety disorder such as post-traumatic stress or obsessive-compulsive disorder. Traditional schools are not set up to deal with these issues, so an alternative school like must be found. Whether your son or daughter has turned to drug abuse, is suffering from depression or an eating disorder, or is struggling from another behavioral issue, a boarding school offers the essential structured, academic program necessary for self discovery and healing, including character therapeutic boarding schools, wilderness programs or emotional growth schools. boarding school that serves troubled teenage boys and girls from the northeast, including: New York, Massachusetts, Pennsylvania, Michigan, New Jersey, Ohio, Indiana, Illinois, Maryland and Connecticut.


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Close Trump allies behind rally that sparked U.S. Capitol riot: recordsBandits kill 80-year-old woman, 4 others in parts of KadunaCOVID-19: Aviation Roundtable urges domestic operators to consider mergerEuropean leaders, Biden call for immediate release of Kremlin critic Alexei NavalnyEngland expands Covid-19 vaccination programme to more groupsSlum to Classroom takes free education to MakokoKano schools' resumption date remains January 18, says CommissionerUS capitals see few protesters after bracing for violencePDP mourns Taraba traditional ruler, Emmanuel NjiwahBranson's Virgin Orbit reaches space with key mid-air rocket launchAnita Joseph brandishes new-look bodyMessi sees red as Barca slump to late Inaki winnerLive Report – Australia vs India, 4th Test, Brisbane, 4th dayProspect of pardons in final days fuels market to buy access to TrumpUK coronavirus variant infects scores at Belgian retirement home
Pravin Amre rejoins Delhi Capitals as assistant coach
The former India batsman had played a key role in the Mumbai Indians' victorious IPL 2020 campaign
Pravin Amre (second from left) was the Capitals' head talent scout from 2014 to 2019
Pravin Amre, the former India batsman, has returned to the Delhi Capitals as assistant coach to Ricky Ponting. Amre had earlier served as the Capitals' head talent scout from 2014 to 2019.
Since November 2019, Amre had been part of the Mumbai Indians' staff, and had played a key role in helping the likes of Suryakumar Yadav and Ishan Kishan grow into consistent performers during the team's victorious IPL 2020 campaign.
In his previous stint at the Capitals, Amre was instrumental in shaping the team's batting core of Shreyas Iyer, Rishabh Pant, Prithvi Shaw and Shikhar Dhawan. He has also enjoyed a long association with Ajinkya Rahane, another Capitals player, as his personal coach, and won three Ranji Trophy titles as the coach of Mumbai.
"I am grateful to the Delhi Capitals management for having me on board," Amre said in a press release. "With the team having reached its very first IPL final in 2020, this is certainly an exciting time to be back there. I look forward to working with Ricky again, and all the players."
Amre played 11 Tests for India from November 1992 to August 1993, scoring 425 runs at an average of 42.50, including a backs-to-the-wall century on debut against South Africa in Durban. He also played 37 ODIs, scoring 513 runs at 20.52.
"I would like to take this opportunity to welcome Pravin Amre back to the Delhi Capitals side," the Capitals' CEO Dhiraj Malhotra said. "Ours is a team with an Indian core, and that thought process applies to our coaching staff as well. Few coaches know the domestic cricket scene in India as thoroughly as Amre does. He has been instrumental in getting the likes of Shreyas, Rishabh and Prithvi to our franchise, and his experience will once again be extremely valuable for us. We are delighted to have him on board."
Alan Burgess, New Zealand first-class cricketer and World War II veteran, dies aged 100
#EndSARS: Forensic experts probe Lekki Tollgate shootings
The news on Pravin Amre rejoins Delhi Capitals as assistant coach, first appeared on ournaijanews.com


Hadi Pourmohseni bought one of the most expensive supercars in the world, a $160,000 BMW M6.
He expected to receive the best of German engineering, but instead was left with a bad taste in his mouth after mechanics in Italy and Germany couldn't or wouldn't fix his defective car.
As a form of protest, Hadi had his Beemer delivered to the Frankfurt International Motor Show where he and his friends smashed the faulty car with sledgehammers and an ax.
After being published by German YouTuber Regine k, the video has gone viral!
Already, the clip has amassed over 1.3 million views since the weekend and has been covered on popular sites such as DailyPicks, CarScoop, and BusinessInsider.
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candidate's photo (50KB), signature (50 KB), thumb impression (50 KB), documents(150kb) related to all educational qualification and reservation need to be scanned in (.jpg) format in system or pendrive.
The name of the candidate, photo date and father's name should be mentioned on the photo. Photos should not be before January 31, 2019. Candidate's face should be clearly visible on the photo and should not be photographed by putting CAP or glasses.
Before applying online, the candidate must have a valid mobile number and email id. In order to verify, information related to OTP, registration details and entrance examination will be sent to registered mobile number. Therefore, the candidate must register their mobile number and keep the registered mobile number with you till the counseling. Mobile registered mobile number cannot be changed later.
(i) First visit the official website of Dr. Ram ManoharLohiya Institute of Medical Sciences, Lucknow https://drrmlims.com or https://drrmlims.ac.in.
(ii) Click on the Student Corner link given on the website. After the next page opens, online Registration for M.Sc. Click Nuclear Medicine Test-2019. Apply online according to the STEP given there after.
First of all download the brochure and study it well. This will make you aware about your preferential qualification and age range.
2. When the given page opens, fill in all the information (Name, Father Name, Category, mob, dob, email carefully and click Submit.
3. An OTP will appear on Registered Mobile No. Enter OTP in the OTP BOX and Click here to verify.
4. When the next page opens, fill all your personal details (Father Name, Mother Name, Gender, Category, Sub Category, Exam Center, Alternate Mobile No, Address) carefully and click on Next below.
5. When the next page opens, upload all your Required Attachment (Photo, Signature, Educational Certificate and other) and click on Upload.
1. After 24 hours of completion of the STEP-2 process, click Fees Submission.
2.when the next page opens, in Fees Category choose RML M.Sc. Nuclear Medicine Entrance Test-2019 and Register No. And Date of Birth (DDMMYYYY) and click on Submit.
3.The next page will open all your details, fill the information requested below and click Submit and complete the online application process.
4. Next page will open all your details, click Submit.
5.On the next page, payment option (MOPS) will open. At your convenience, you can make online payments through debit card, net banking or through a user. Payment can be made in any branch of SBI through a bank invoice. After the 24 hours of making the payment, final printout of application can be taken.
after 24 Hours of Online Application Fee Deposit, click Final Print Out.
Candidate must possess minimum 60 per cent marks for general and OBC candidate ( 55 % marks in case of SC/ST candidates) in ( B.Sc. degree courses in Nuclear Medicine or B.Sc. degree in Physics or B.Sc. in allied/related subject i.e. Radio Diagnosis, Radiotherapy or B.Sc. in Life Sciences / Chemistry / Mathematics/ Statistics with Physics as a subject from recognized University).
(i) Age: The candidate should have completed 17 years of age, but should not be more than 35 completed years of age, as on 01st July 2019.
(ii) Candidate should be a domicile of Uttar Pradesh in order to get reservation benefits.
(iii) Candidate should be medically fit, and would need to pass a separate medical examination, as per rules and regulations of the Institute.


Enables you to access the DockItem class to manipulate the dock item associated with the window (macOS only).
The DockItem class has two methods, UpdateNow and ResetIcon, and one property, Graphics. Use the methods of the Graphics class to modify the appearance of the icon. (The Graphics property may be Nil; it is non-Nil only when a macOS window has been minimized to the dock.) The ResetIcon method resets the icon to its original state (default appearance). Since a macOS icon is intended to be scaled automatically, you should design it as a 512 x512 pixel icon and include smaller sizes. Call the UpdateNow method to redraw the icon. You can also use the ClearRect property of the Graphics class to start over form a blank icon. Anything you can do with a Graphics object you are able to do with the Dock's Graphics object (like drawing in a picture or using a Shape 2D). The Dockitem property of the Application class enables you to control the DockItem for the whole application.
This page was last edited on 1 June 2017, at 17:46.


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Two killed in Upstate crash, juvenile sent to hospital, troopers say
The crash happened on Lockhart Highway
WYFF News 4
Vehicle Crash
SOURCE: WYFF News 4
The Union County coroner is investigating a crash that killed two people and sent a juvenile to a hospital.Two cars were involved in the crash, according to the South Carolina Highway Patrol. The crash happened on Lockhart Highway around 5:30 p.m. Saturday.One driver crossed the center line and hit the other car head-on, according to SCHP. Both drivers died at the scene, according to the coroner. The juvenile was airlifted to a hospital, troopers said.No other details have been released.
UNION COUNTY, S.C. —
The Union County coroner is investigating a crash that killed two people and sent a juvenile to a hospital.
Two cars were involved in the crash, according to the South Carolina Highway Patrol. The crash happened on Lockhart Highway around 5:30 p.m. Saturday.
One driver crossed the center line and hit the other car head-on, according to SCHP. Both drivers died at the scene, according to the coroner. The juvenile was airlifted to a hospital, troopers said.
No other details have been released.


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Seweryn Bialer (1926-2019)
Robert and Renée Belfer Professor Emeritus of International Relations
Born in Berlin in 1926, he was raised in Lodz in a prominent Polish Jewish family. He was driven into the Lodz ghetto at age 13, where he discovered the works of Karl Marx, which would become a lifelong study. There he joined the communist underground. In 1944 he was sent to Auschwitz/Birkenau concentration camp and from there, with the dismantling of this camp, to Friedland, which was liberated by Soviet troops in May 1945. In 1951 he was admitted to the Polish Academy of Sciences Institute for the Education of Scientific Cadres. There he prepared his doctoral dissertation on the U.S. Marshall Plan, while serving as lecturer and member of various Central Committee commissions dealing with propaganda, publications and education. In January 1956, he defected to the West while attending an international conference in Berlin. His first book, Stalin and His Generals. Soviet Military Memoirs of World War II (1969) was translated into several European languages. Harrison Salisbury hailed the work as "an unprecedented glimpse of Stalin through the eyes of his associates" (New York Times, April 27, 1969). Bialer's next book, Stalin's Successors: Leadership, Stability and Change in the Soviet Union (1980), secured his position as a leading expert in Soviet studies, which was recognized three years later when he was awarded the MacArthur Fellowship, the first ever given to a political scientist, and the only one awarded to a Sovietologist. Seweryn Bialer is survived by his wife of 51 years, Joan Afferica, L. Clarke Seelye Professor Emeritus of History, Smith College, Northampton, Massachusetts. New York Times Obituary Harriman Magazine
Born in Berlin in 1926, he was raised in Lodz in a prominent Polish Jewish family. He was driven into the Lodz ghetto at age 13, where he discovered the works of Karl Marx, which would become a lifelong study. There he joined the communist underground. In 1944 he was sent to Auschwitz/Birkenau concentration camp and from there, with the dismantling of this camp, to Friedland, which was liberated by Soviet troops in May 1945. In 1951 he was admitted to the Polish Academy of Sciences Institute for the Education of Scientific Cadres. There he prepared his doctoral dissertation on the U.S. Marshall Plan, while serving as lecturer and member of various Central Committee commissions dealing with propaganda, publications and education. In January 1956, he defected to the West while attending an international conference in Berlin.
His first book, Stalin and His Generals. Soviet Military Memoirs of World War II (1969) was translated into several European languages. Harrison Salisbury hailed the work as "an unprecedented glimpse of Stalin through the eyes of his associates" (New York Times, April 27, 1969). Bialer's next book, Stalin's Successors: Leadership, Stability and Change in the Soviet Union (1980), secured his position as a leading expert in Soviet studies, which was recognized three years later when he was awarded the MacArthur Fellowship, the first ever given to a political scientist, and the only one awarded to a Sovietologist.
Seweryn Bialer is survived by his wife of 51 years, Joan Afferica, L. Clarke Seelye Professor Emeritus of History, Smith College, Northampton, Massachusetts.
New York Times Obituary


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Home > Buzz SPOTTED: BravoLebs on TV before they were on Bravo!
SPOTTED: BravoLebs on TV before they were on Bravo!
Find out which Bravolebs made TV appearances before they hit it big on Bravo!
Jaimee Palkovicz February 28, 2018 9:20am
If one thing can be said about reality TV, it's that it's totally incestuous! No need to do a double take, you probably did see that familiar Bravo face on that episode of your old favorite show. It's crazy to think, but we've been watching our favorite Bravo stars for years and we didn't even know it. Unbeknownst to us, many Bravo stars have graced our televisions way before we even knew them by name. These Bravolebs have been infiltrating our Reality TV viewing since early 2000's without us even knowing it. Here are the Bravo stars that have popped up in iconic reality TV shows of the past.
If you've watched The Hills recently you may notice some familiar faces that you didn't notice before. Lady Gaga, Kim Kardashian (showed on The Hills ten year anniversary special), and even Vanderpump Rules' very ownTom Sandoval. On The Hills, we see a young, shirtless, and hairless Tom Sandoval, in the spotlight – his favorite place to be. He was interviewed for a modeling gig with Teen Vogue. Tom has come a long way from The Hills. Not only is he a regular on Vanderpump Rules, but also a partner with Lisa Vanderpump on her newest restaurant, TomTom!
Scheana Shay
For Scheana Shay, "it's all happening" since she was spotted in the background on The Hills. Scheana can be spotted On The Hills, with BFF Stacie Adams, aka Stacie the bartender, who was known for trying to get in the way of Spencer Pratt and Heidi Montag's relationship. Years later, Scheana herself was "unknowingly" (according to her, which we know is complete bull****. Have you not heard of Google?) dating a married man (Eddie Cibrian), and is currently on VPR with BFF Ariana Madix, who hooked-up with Tom Sandoval while he was with Kristen Doute. Scheana's taste in friends clearly hasn't changed much, #homewreckingwhoreposse. You can also spot Stacie as one of Scheana's bridesmaids during her wedding to Mike Shay, where she was thinking about Rob Valletta the whole time.
Stassi Schroeder
Stassi Schroeder may have been queen bee when VPR started, but it took a lot of practice to earn that title. At 19, Stassi starred in the show, "Queen Bees". The show was mainly about mean girls, and teaching them how to be nice. She didn't learn much, and she was hurtful towards her friends, and on Vanderpump Rules season 2/3 that was exiled from the SUR group. That is until she crawled her way back from New York, as stated by The White Kanye (James Kennedy) in the season 5 reunion. She was also on the family edition of The Amazing Race, pre-chin implant.
Bethenny Frankle
Bethenny Frankle has been hustling and overly promoting her brand way before she started her strategic product placement on RHONY in 2008. In 2005 Bethenny tried her hand at the Apprentice with Martha Stewart. The Skinny Girl fell short of coming in first, despite her "know-it all attitude." With the Skinny-Girl empire she has grown, maybe she does, KNOW IT ALL, and maybe Martha should have listened!
Tinsley Mortimer
Tinsley Mortimer was running the New York City social scene way before RHONY hit our TV's. The show High Society featured Tinsley and her friends living a High Society New York City lifestyle. The show ended not long after it started. Shortly after, Tinsley got arrested for trespassing in Palm Beach (Or was it West Palm Beach?). This lead to her infamous arrest and mugshot. In my opinion, those events helped her pave her way back onto our screens when she was cast on RHONY. We thank her, and her lashes for making bad decisions that lead her to Bravo.
Siggy Flicker
Before Soggy, I mean Siggy, was on Bravo, she had a show called, Why Am I still Single?. The show only ran for 1 season, which doesn't shock me.
Siggy Flicker barely made it through 2 seasons of The Real Housewives of New Jersey, which she blames on editing. I'm sure if you ask her why the VH1 show didn't make it past the first season, her response would be the same. Her departure of both shows must have nothing to do with the fact that she can't handle criticism, or the dynamic of reality TV.
Kyle Richards
As many of us know,Kyle Richards was a child actor and starred in many shows and movies. But, before all the glitz, glam, and injectable, Kyle made a small appearance on her niece Paris Hilton's show, The Simple Life in the early 2000's. Thank goodness the times have changed, and so has Kyles hair, makeup and nose. Btw, this vintage picture of Kyle Richards is totally giving me Giada DeLaurentis vibes.
Enjoy this clip of Stassi in the Queen Bees trailer!
Have you spotted any Bravo stars in other shows?! Tell us in the comments!
Category: Lists & GIFS Tags: Bravo, Kim Kardashian, Kyle Richards, Sheana Shay, Stassi Schroeder, Tom Sandoval
Be the first to leave Comments for SPOTTED: BravoLebs on TV before they were on Bravo!


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Benvenuto Tisi Garofalo (* 1481 in Ferrara; † 6. September 1559 in Ferrara; eigentlich Benvenuto Tisi, genannt Il Garofalo) war ein italienischer Maler.

Garofalo lernte seit 1491 bei Domenico Panetti in Ferrara und begab sich 1498 auf die Wanderschaft, die ihn zu Boccaccio Boccaccini in Cremona führte. Im Januar 1499 verließ er diesen heimlich und ging nach Rom, wo er sich dem Florentiner Giovanni Baldini angeschlossen haben soll. 1501 siedelte er nach Bologna über, wo er zwei Jahre bei Lorenzo Costa der Ältere blieb, kehrte aber 1504 nach Ferrara zurück und arbeitete hier mehrere Jahre mit den Gebrüdern Dossi, Battista Dossi und Dosso Dossi, zusammen. Er schuf u. a. auch Deckenmalereien, wie die in einer Erdgeschoss-Halle des Palazzo Costabili in Ferrara.

1509 begab er sich zum zweiten Mal nach Rom, schloss sich hier an Raffael an und bemühte sich, seinen lombardischen Stil an den Stil Raffaels anzupassen. Um 1512 kehrte er wieder in seine Vaterstadt zurück, wo er zahlreiche Aufträge Herzog Alfons annahm. Obwohl seit 1530 auf einem Auge blind war, malte er weiter, bis er jedoch 1550 vollends erblindete. Garofalo starb am 6. September 1559. Seinen Beinamen erhielt er von der Nelke (Garofalo), die er im Wappen führte.

Werkverzeichnis
 London, National Gallery, Madonna col Bambino e i Santi Domenico e Caterina, Öl auf Holz, 46 × 34 cm, circa 1500–1510
 Pavia, Pinacoteca Malaspina, Sposalizio della Vergine, Öl auf Holz, 50,5 × 32,7 cm, circa 1500–1510
 Neapel, Museo Nazionale di Capodimonte, Madonna con Bambino e San Girolamo, Öl auf Holz, 38 × 43 cm, 1510–1512
 Gemäldegalerie Alte Meister, Poseidon und Athene, Leinwand, 211 × 140 cm, 1512 Nov.
 Rom, Galleria Nazionale di Arte Antica, Ascensione di Cristo, Öl auf Holz, 314 × 204,5 cm, 1510–1520
 Ferrara, Pinacoteca Nazionale, in collaborazione con Dosso Dossi, Polittico Costabili, Öl auf Holz, 960 × 577 cm, circa 1513–1525
 Amsterdam, Rijksmuseum, Madonna col Bambino, Öl auf Holz, 61 × 46 cm, circa 1515
 Neapel, Gallerie Nazionali di Capodimonte, Circonicisione, Öl auf Holz, 39 × 54, circa 1515
 London, National Gallery: Santa Caterina d'Alessandria, Öl auf Holz, 45 × 38 cm, circa 1515–1530 (attributiert)
 London, National Gallery: Madonna col Bambino in trono e Santi. Öl auf Holz, 198 × 208 cm, 1517–1518.
 Paris, Louvre, Circoncisione, Öl auf Holz, 38 × 50 cm, circa 1519
 Wien, Kunsthistorisches Museum, Resurrezione di Cristo, Öl auf Holz, 314 × 181 cm, 1520
 London, National Gallery: Sacra Famiglia e Santi. Öl auf Leinwand, 60 × 47 cm, circa 1520
 St. Petersburg, Eremitage, Deposizione nel sepolcro, Öl auf Leinwand, 53 × 75,5 cm, circa 1520
 London, National Gallery: Visione di Sant'Agostino, Öl auf Holz, 64 × 81 cm, circa 1520
 London, National Gallery: Orazione nell'orto, Öl auf Holz, 49 × 38 cm, circa 1520–1539
 Wien, Kunsthistorisches Museum, San Rocco, Öl auf Leinwand, 94 × 51,4 cm, 1525–1530
 Wien, Kunsthistorisches Museum: Noli me tangere. Öl auf Leinwand, 56 × 73,3 cm, 1525–1530
 London, National Gallery: Un sacrificio pagano. Öl auf Leinwand, 128 × 185 cm, 1526
 Neapel, Gallerie Nazionali di Capodimonte: San Sebastiano. Öl auf Holz, 37 × 30 cm, circa 1526
 London, National Gallery: Allegoria dell'amore, Öl auf Leinwand, 127 × 177 cm, circa 1527–1539
 Rom, Pinacoteca Capitolina, Annunciazione, Öl auf Leinwand, 103 × 132 cm, 1528
 New York, Metropolitan Museum of Art, San Nicola da Tolentino resuscita un bambino, Öl auf Leinwand, 33 × 65 cm, circa 1530
 Amsterdam, Rijksmuseum: Adorazione dei Magi. Öl auf Holz, 79 × 58 cm, circa 1530
 Detroit, Institute of Arts: Sacra Famiglia con Sant'Anna, Öl auf Leinwand, circa 1530
 St. Petersburg, Eremitage: Nozze di Cana. Öl auf Leinwand, 306 × 248 cm, 1531
 Modena, Galleria Estense, Madonna col Bambino in trono e santi, Öl auf Leinwand, 286 × 162 cm, 1533
 Hampton Court, Royal Collection, Sacra Famiglia, Öl auf Holz, 42 × 55 cm, 1533
 Miami, Lowe Art Museum, Madonna col Bambino in gloria, Tempera und Öl auf Holz, 39 × 26 cm, circa 1535
 Amsterdam, Rijksmuseum: Sacra Famiglia, san Giovannino, san Zaccaria e santa Elisabetta. Öl auf Holz, 51 × 37 cm, circa 1535
 Florenz, Galleria degli Uffizi, Annunciazione, Öl auf Holz, 55 × 76, 1528
 Neapel, Gallerie Nazionali di Capodimonte, Adorazione dei Magi, Öl auf Holz, 78 × 55 cm, ca. 1540
 Vatikanstadt, Pinacoteca Vaticana, La Vergine appare ad Augusto e alla Sibilla, Öl auf Holz, 143 × 118 cm, 1544
 Mailand, Pinacoteca di Brera, Annunciazione, Öl auf Leinwand, circa 1550
 El Paso, Museum of Art: Circoncisione di Cristo. Öl auf Leinwand, 48 × 60 cm, circa 1550
 Isola di Fondra (Bergamo), Annunciazione, Chiesa di San Lorenzo, circa 1500
 Voghiera (FE)
 Triumph des Bacchus, Staatliche Kunstsammlungen Dresden seit 1746

Weblinks

 Mariä Verkündigung (The Annunciation), Pinacoteca di Brera, Mailand
 Auferstehung Christi (Ascension of Christ), Galleria Nazionale d'Arte Antica, Rome
 Werke von Garofalo bei Census of Ferrarese Paintings and Drawings

Einzelnachweise

Maler (Italien)
Geboren 1481
Gestorben 1559
Mann


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Jailors Jailed in Tuzla
Eleven people including four prison officials were arrested in Tuzla, Bosnia and Herzegovina on Monday on suspicion of drug trafficking, according to a government press release.
Six of the eleven people arrested were charged with the production and sale of drugs, four are prison guards and one served as a middleman.
The arrests were part of Operation Brava, conducted by the State Investigation and Protection Agency (SIPA) and the Tuzla Canton Ministry of the Interior to collect evidence relating to "the abuse of official position and illicit trafficking in narcotic drugs." The operation included the search of 18 properties in Tuzla, Lukavac and Živinice including six properties that belong to the Tuzla Correctional Facility.
Last night, two more people were arrested and half of a kilogram what is thought to be heroin was found in Lukavac.
Video of the arrest can be found here.
Mexico: Drug War Policy Could Facilitate Corruption
UNODC: Africa Vulnerable to Drug Trafficking
Balkans: Drug Smuggling Ring Broken
Kosovo: Kelmendi to be Held for One Month
Guinea Bissau Military Chief Indicted in Drug Scandal
Drug Kingpin Arrested in Int'l Waters Faces Trial
Bosnia: Top Officials Charged in Weapons Investigation
Report: The Evolution of Organized Crime in Bosnia and Herzegovina
Colombian 'Queen of Cocaine' MurderedColombian 'Queen of Cocaine' Murdered
Gulf Cartel Leader Captured
Maldives Ex-President Jailed Over Island Lease Bribery and Embezzlement


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You are here: Home / Sports / MLB / MLB Insider Reveals An Important Hall Of Fame Voting Group
MLB Insider Reveals An Important Hall Of Fame Voting Group
(Photo by Lachlan Cunningham/Getty Images)
Former MLB stars Barry Bonds and Roger Clemens will get another chance to enter the National Baseball Hall of Fame after failing to be elected via the traditional BBWAA (Baseball Writers' Association of America) way for 15 years.
On the field, both were among the most dominant players of their time.
Bonds has the record for most home runs in a season (73) and career (762), while Clemens won an MLB-high seven Cy Young awards in his brilliant MLB tenure.
Both, however, are linked with the use of steroids and weren't exactly popular among media members.
The Contemporary Era committee will vote on whether the two players make the Hall.
Thanks to Bill Shaikin, we have the names of the 16 people who will vote on both stars' destiny.
"The committee that will vote next month on whether Barry Bonds and Roger Clemens make the Hall of Fame," Shaikin tweeted, with the 16 names.
The committee that will vote next month on whether Barry Bonds and Roger Clemens make the Hall of Fame. pic.twitter.com/Xo29dtaL5k
— Bill Shaikin (@BillShaikin) November 28, 2022
All candidates receiving votes on at least 75% of ballots cast will earn election, meaning that Bonds and Clemens will need at least 12 yes votes.
Will They Make It To Cooperstown?
That group includes several players who shared a field with Bonds, as well as historians who made their career in the Bay Area, where Bonds played for more than a decade.
There is a considerable chance both players eventually make it to the Hall.
Former Boston Red Sox slugger David Ortiz was the only player to make the Hall in the last voting process.
Bonds finished with 66 percent and Clemens was at 65.2 percent: they were both relatively close, but fell short.
They both used steroids in an era in which a considerable percentage of the league did, too, and their use didn't carry a penalty at the time.
Will they make the Hall?


I have a client using Outlook 2019 where any time he responds yes to sending a read receipt the message fails to send with SMTP error 452 4.1.0.
If I change his smtp server to a different provider the messages go through.
Because read receipts do not appear in the outbox they have to be manually removed from the mailbox or Outlook continues to attempt to send them in the background causing terrible mail delays.


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Ashbury F Style Bluegrass Mandolin Solid carved AA spruce top with solid maple back and sides. Scroll body.
Ashbury F Style Bluegrass Mandolin Solid carved AA spruce top with solid curly maple back and sides. Scroll Body.


text:
Agents of S.H.I.E.L.D.: The Writing on the Wall
by sunbunny
"What does it mean, Coulson?"
After a two week absence, Agents of S.H.I.E.L.D. is back. With May putting up lost puppy posters for Ward, Coulson and Skye were left without adult supervision. Chaos obviously ensued. (No, your eyes aren't deceiving you. This is Sunbunny. Mark and I switched shows for a week.)
Why didn't we see Ward escape? Was Agents of S.H.I.E.L.D. looking to save some money by nixing an expensive, stunt-heavy scene or were they intentionally leaving Ward's actions there vague? Since the season started, we haven't actually seen him do anything evil. He escaped from custody, but we didn't see him kill anyone doing that. He may have killed the Hydra guys, but again, we didn't see it and I'm wondering if that's important.
It's really impossible to tell where they're going with Ward right now. It could be the start of Ward's big redemption arc. It could be him going completely dark side. The writers are keeping it vague which, from a showrunning standpoint, is smart. It keeps the audience wondering and tuning in. From a personal standpoint, just freaking tell me already what is going on with Ward? Was he really lying about the abuse or is Christian evil or are both evil what is going on?!?!
At the time of Ward's escape, I was wondering if Coulson made it easy for him to escape on purpose. Coulson knows Ward. He knows what he's capable of. Did a pair of regulation handcuffs and a van really seem sufficient? I'm not saying Ward is on a secret mission from Coulson, but it seems completely possible to me that Coulson is waiting for Ward to lead him to someone or something. And then, why did Ward leave Bakshi for Coulson? Was he genuinely trying to help out S.H.I.E.L.D., trying to win back some measure of trust? Or is having Bakshi in S.H.I.E.L.D. custody a part of some bigger, darker plan? I like what's going on with Ward right now. Being on the loose, possibly helping S.H.I.E.L.D., or possibly just serving his own needs, and totally obsessed with Skye is exactly where I wanted him. Agents of S.H.I.E.L.D.'s Julian Sark. I'm excited but apprehensive to see where they're going to take him. Unlike some people, I'm choosing to believe Grant Ward over Christian Ward. I hope I'm not wrong...
While May and the most of the combat-ready S.H.I.E.L.D. agents were off chasing their tails Ward, Coulson and Skye decided it would be a great idea to use some leftover Dollhouse tech to try to get Coulson to remember something so painful and crazy making he had literally wiped from his mind, Eternal Sunshine-style. Because what on earth could go wrong? I have a hard time seeing the Coulson/May/Skye dynamic as anything else besides a family. Skye calling May and May's initial anger and eventual resignation was just so... mom. Clearly, May's the disciplinarian whereas Coulson is the 'sure sweetie, you can play with the dangerous technology no one understands' parent. At least Coulson's need to deface S.H.I.E.L.D. property has subsided. May was spending a fortune on spackling and repainting his office.
The geometric pattern of doom turns out to be three dimensional. And a city. Going from three dimensional to definitely a city felt like a bit of a leap but whatever. It's a city. Which city? Probably not one on Earth, given that the image of the city came from the body of an ancient Smurf. I don't really care about the whole Obelisk/Tahiti thing, but the idea that Smurfy wanted to get to that place so much its image was literally in his blood is bizarrely beautiful. So what does that mean? Was it Smurfy's home? Was he on his way home when he was bisected and stuck in Jello? I'm guessing the whole thing will tie in with the expansion of the MCU mythology we saw in this summer's Guardians of the Galaxy which introduced more alien civilizations and races, including blue ones. And now that Selfie (at one point, Agents of S.H.I.E.L.D.'s lead in) has been cancelled, maybe a certain blue alien wouldn't mind dropping by for a week or six? #ItsAllConnected
Paging Blue Amy Pond
All in all, it was a good episode, but I felt, like I usually do, the episode spent too much time chasing MacGuffins. I like the characters on the show so much I'd watch an entire episode of them just hanging out and playing UpWord or eating shwarma. I also have to fault the show for continuing to break up the team in the same way. Fitz and Mack, Skye and Coulson, Bobbi and Hunter. Can we mix it up a bit next week? Or, better yet, don't break up the team. I like them all together and not headed out in different directions to put out HYDRA fires (put one out, another two start in its place).
Intel and Assets
--Bobbi and Hunter maintain their track record of being an adorable, bickering, sarcastic, divorced couple still crazy in love but unable to admit it. I just enjoy them more and more. Also highly enjoyable is May's frustration with the pair of them.
--The HYDRA guys who came to meet Ward parked in front of a fire hydrant. Does their evil know no bounds?
--I wonder how long Skye was waving her arms around in that cell while Mack and Fitz were playing video games. That couldn't have felt good.
Skye: "You two don't have a single thing in common unless you have some Enya albums you've been hiding."
Fitz: "Corpsey Diem. Seize the dead."
Bartender: "I'll give you a choice. Columbian necktie or bullet in the head."
Ward: "Bullet in the head. On the rocks."
*bartender pours drink*
Hunter: "Subtlety is key."
Bobbi: "You were dressed like a cowboy!"
three out of four bullets in the head
sunbunny, who is not Mark Greig
Agents of S.H.I.E.L.D. home
Labels: :S2.E7, Agents of S.H.I.E.L.D., Agents of S.H.I.E.L.D. reviews, Sunbunny, The Writing on the Wall
Hooray for bringing in Joel Gretsch as a guest star(the last man standing of the test subjects who chose to stay with his implanted memories), I always enjoy seeing him.
It does seem like they've wrapped up the whole "what does it mean?!?!" part of this story arc a little too quickly, but then again one of the biggest complaints people had about Season 1 was that it moved too slowly in the first half.
I have a feeling the city is actually on Earth, if only because of the whole "Chekov's Gun" of it all. The show isn't going to be taking this team off-planet, and you don't introduce the idea of a mysterious city and say that the good guys and the bad guys are both trying to find it, only to put it somewhere neither of them can actually reach. The only way I could see it actually being off-world is if there's some kind of portal to it here on Earth, which could be a bit of a cop-out. My best theory right now is that the city is here, and that it's very, very old. Going with the "It's All Connected" theme, I find myself wondering if this isn't somehow linked to the Inhumans, and if the city they're now searching for won't turn out to be Attilan.
Wednesday, November 12, 2014 at 3:56:00 PM PST
migmit said...
I'm all for having Karen on that show, but please, not in this ridiculous makeup.
Thursday, November 13, 2014 at 6:20:00 AM PST
great review sunbunny - laughed out loud a couple of times. I agree with you that I would watch this group doing just about anything and I am also on the Ward is redeeming himself team. I liked the city and the 3 dimensional nature of the message. I feel sorry for the poor alien who even in his very blood just wanted to go home.
Thursday, November 13, 2014 at 7:00:00 PM PST
Yes, very funny review -- I laughed out loud more than once. And I am also certain that Ward didn't escape by accident. I bet Coulson let him go on purpose. And I'm glad they finally got to the meaning of the carvings, because it was getting a bit old.
Friday, November 14, 2014 at 6:40:00 AM PST
Docnaz said...
I loved the reference to John le Carre´s 1963 novel The Spy Who Came In from the Cold when Ward was in the bar and the 3 men in suits came in and greeted him with " Grant Ward...in from the cold at last".


text:
Members of the Youth Parliament from Nottinghamshire attend sitting in House of Commons
Members of Youth Parliament (MYPs) representing Nottinghamshire, who are supported by the Council's Youth Service, sat in the House of Commons to discuss issues facing young people, specifically the cost of living and health, as well as mental health challenges.
Youth Parliament members Oliver Key, MYP for Rushcliffe, Muhammed Malik, MYP for Gedling, Darcy Griffiths, MYP for Bassetlaw and Gemini Tait, MYP for Pioneers, were among more than 100 young people from across the country who participated in the sitting, which provided a platform for them to voice their concerns and offer solutions to important issues.
This annual debate held in the House of Commons chamber was chaired by Speaker of the House, Rt Hon Sir Lindsey Hoyle MP.
The MYPs debated five issues chosen by a ballot of young people from across the UK, and a vote was held to decide which two issues should become the UK Youth Parliament's priority campaigns for 2023. UK Youth Parliament has chosen to focus on the cost of living and health.
During the sitting, the Nottinghamshire members emphasised the need for increased mental health support for young people and highlighted the growing costs of living, including food, transportation and other day-to-day essentials. They proposed several solutions to address these issues, including improved mental health and more affordable public transport for young people.
Speaking about her experience of sitting in the Chamber, Darcy Griffiths said: "Speaking in the House of Commons, though daunting, was an incredible experience. I am so appreciative of the opportunity to attend.
"Public speaking has always been an issue of mine, but now that I have joined a televised debate in the Houses of Commons, I feel much more confident about speaking up in the future.
"I was amazed by the extensive knowledge and passion that all members of the Youth Parliament have. I know that we can trust these people to be the leaders of the future."
This participation in the sitting is a positive step for Nottinghamshire, as it gives young people in the county a chance to have their voices heard and contribute to important discussions on problems faced by young people. It also shows the commitment of Nottinghamshire to supporting the future leaders of the county.
Gemini Tait, MYP for Pioneers, said: "This was a fantastic opportunity and was very interesting to see other young people's views on topics that not only effect adults but young people as well."
The members of the British Youth Parliament will continue to work on these and other issues affecting young people and will continue to engage with local and national decision makers to advocate for positive change.
Nottinghamshire County Council Leader, Councillor Ben Bradley MP, said: "I am proud of the Nottinghamshire members of the Youth Parliament and their commitment to raising important issues affecting young people. Their presence at the House of Commons is a great example of how young people can make a real difference in their communities."
Membersofyouthparliament [0.15MB]
< Back to: News


text:
Q: bottom align a button in R shiny I cannot figure out a way to bottom align downloadButton with a selectizeInput, i.e.,

library(shiny)

runApp(list(
  ui = shinyUI(fluidPage(
    fluidRow(align="bottom",
      column(12, align="bottom",
             h4("Download Options:"),
             fluidRow(align="bottom",
                      column(6, selectizeInput("plot_dl", "File Type", width="100%",
                                               choices = list("PDF"="pdf","PNG"="png"))),
                      column(3, downloadButton('plot1_dl', 'Left Plot')),
                      column(3, downloadButton('plot2_dl', 'Right Plot'))
             )
      )
    ),
    tags$style(type='text/css', "#plot1_dl { width:100%; vertical-align:bottom}"),
    tags$style(type='text/css', "#plot2_dl { width:100%;}")
  )),
  server = function(input, output) {
  }
))

Placing align="bottom" anywhere and everywhere does not throw an error message, but does not have the desired effect either. Tried playing around with the style tags of the buttons, but well out my depth.

A: Found an ad-hoc fix with margin-top: 25px in the style tag...

library(shiny)

runApp(list(
  ui = shinyUI(fluidPage(
     h4("Download Options:"),
     fluidRow(
       column(6, selectizeInput("plot_dl", "File Type", width="100%",
                                choices = list("PDF"="pdf","PNG"="png"))),
       column(3, downloadButton('plot1_dl', 'Left Plot')),
       column(3, downloadButton('plot2_dl', 'Right Plot'))
     ),
     tags$style(type='text/css', "#plot1_dl { width:100%; margin-top: 25px;}"),
     tags$style(type='text/css', "#plot2_dl { width:100%; margin-top: 25px;}")
  )),
  server = function(input, output) {
  }
))

A: Other way to do it is to pass style argument in the column function.

runApp(list(
        ui = shinyUI(fluidPage(
                h4("Download Options:"),
                fluidRow(
                        column(6, selectizeInput("plot_dl", "File Type", width="100%",
                                                 choices = list("PDF"="pdf","PNG"="png"))),
                        column(3, style = "margin-top: 25px;", downloadButton('plot1_dl', 'Left Plot')),
                        column(3, style = "margin-top: 25px;", downloadButton('plot2_dl', 'Right Plot'))
                )
        )),
        server = function(input, output) {
        }
))

redpajama_set_name: RedPajamaStackExchange


The JCSS highly appreciates and encourages comments, questions and suggestions for improvements concerning the Probabilistic Model Code (PMC) and other work related to the JCSS.
The simplest way to get in contact with the JCSS is by writing an e-mail to the relevant persons. Links to appropriate contact persons and expertise areas may be found under About JCSS. In case of doubt on who to contact please write to Michael Havbro Faber on mfn@civil.aau.dk.
The Joint Committee on Structural Safety consists of a Board, chaired by the President, and a number of Working Parties, chaired by Reporters.


text:
How Can United Airlines Recover from Its PR Nightmare?
(Above: Demonstrators protest United Airlines at O'Hare International Airport on April 11, 2017 in Chicago, Illinois. Photo: AFP/Getty Images, Joshua Lott) United Airlines has been under fire in recent days after the incident where a passenger was forcibly removed from a flight in Chicago. Video of him being dragged down the aisle naturally went viral in […]
Abner Fletcher
| Posted on April 17, 2017, 12:21 PM
(Above: Demonstrators protest United Airlines at O'Hare International Airport on April 11, 2017 in Chicago, Illinois. Photo: AFP/Getty Images, Joshua Lott)
United Airlines has been under fire in recent days after the incident where a passenger was forcibly removed from a flight in Chicago. Video of him being dragged down the aisle naturally went viral in what has roundly been considered a public relations disaster for the airline.
What steps could the airline take to try and recover from this episode? Do airlines have especially challenging public relations hurdles to climb compared to other companies in other industries? And why do many Houstonians still speak positively about Continental Airlines, which was based here before it was bought out by United?
Joining us for this conversation is Julie Fix, director of undergraduate studies at the University of Houston.
Tags airlines customer service Julie Fix passenger public relations travel united airlines university of houston
Political Roundup: The President And The Fourth Of July, And Local Races Expand
UH College of Medicine Launches Residency Program As It Seeks Accreditation
Democratic Candidates Want To Forgive Student Debt, But How Would That Work?
What Is 'Carbon Neutral' Oil And Could It Help Climate Change?
Is Houston Its Own Echo Chamber?
Political Roundup: 'Go Back' Tweets, And Mueller's Testimony Delayed
Full Show: Vote Delayed On Sewage Plan, Political Roundup, And Women's Football In The '70s (July 17, 2019)


Our community's housing problems can seem big and overwhelming, but there are solutions! And you can make them happen by taking action in creative ways. We need people to volunteer, Advocate, Educate, Demonstrate and Donate.
What are your skills, passions and resources? Visit the links below and pick an activity where you can share your unique gifts.
Are any of the activities below unfamiliar to you or outside of your comfort zone? Try one activity in that area! Real solutions require us all to start thinking differently. You never know where you will find a new passion or bring creative ideas to a housing solution.
Ask your elected officials to support affordable housing in our communities. Housing solutions won't happen without strong government partnerships. Learn more about Habitat's Advocacy program and ways you can help.
Demonstrate publicly or in small personal ways that you support housing. Help us bring attention to this important issue.
Financial support is critical to making solutions happen. Support Habitat's mission by making a donation today.
Educate yourself and others about housing issues. Spreading the word gets others involved. Visit our resource page for books, community events, and online tools to help you get started.
Build solutions and relationships with your time. Volunteer at Muskogee Habitat or connect to volunteer opportunities at other housing organizations.


Just before the Christmas holidays, we're shipping maintenance release 3.7.4 of Twixl Publisher, and at the same time, we're also introducing beta 2 of Twixl Publisher 4, that will bring support for phones when it ships early 2015. We've been very excited with the fantastic response we are getting for this beta and would like to thank all beta-testers for their excellent feedback.
" in the Twixl Publisher OS X app, or go to our download page .


text:
Clinical Pharmacology Corner: FDA Approves VERZENIO (Abemaciclib) for Treatment of Certain Advanced or Metastatic Breast Cancers
FDA Approves VERZENIO (Abemaciclib) for Treatment of Certain Advanced or Metastatic Breast Cancers
On September 28, 2017, the U.S. Food and Drug Administration (FDA) approved VERZENIO (abemaciclib) as follows:
In combination with fulvestrant for treatment of women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer with disease progression following endocrine therapy. The approved recommended dose of VERZENIO in combination with fulvestrant is 150 mg taken orally twice daily. When given with VERZENIO, the recommended dose of fulvestrant is 500 mg administered on Days 1, 15, and 29; and once monthly thereafter. Refer to the full prescribing information for fulvestrant linked below. Pre/perimenopausal women treated with the combination of VERZENIO plus fulvestrant should be treated with a gonadotropin-releasing hormone agonist according to current clinical practice standards.
As monotherapy for treatment of adult patients with HR-positive, HER2-negative advanced or metastatic breast cancer with disease progression following endocrine therapy and prior chemotherapy in the metastatic setting. The recommended dose of VERZENIO as monotherapy is 200 mg taken orally twice daily.
Continue treatment until disease progression or unacceptable toxicity. For recommended VERZENIO dose modifications and management for adverse reactions, refer to the applicable full prescribing information linked below.
Mechanism of Action (MOA), General Pharmacokinetics (PK), and Pharmacodynamics (PD)
MOA: VERZENIO is a cyclin-dependent kinase inhibitor.
General PK: Following single and repeated dosing, the increase in AUC and Cmax was dose proportional. The estimated geometric mean accumulation ratio was 2.3 (50% CV) and 3.2 (59% CV) based on Cmax and AUC, respectively.
Absorption: The absolute bioavailability after a single dosing is 45% (19% CV). The median Tmax of abemaciclib is 8.0 hours (range: 4.1-24.0 hours).
Distribution [mean (SD)]: Abemaciclib was 96.3% (1.1) protein bound. Protein binding was similar for the active metabolites M2, M18, and M20. In patients with advanced breast cancer, concentrations of abemaciclib, M2, and M20 in cerebrospinal fluid are comparable to unbound plasma concentrations.
Elimination: The mean plasma elimination half-life for abemaciclib was 18.3 hours (72% CV).
Metabolism: Abemaciclib is metabolized primarily to M2, M18, and M20 by CYP3A4. These active metabolites are equipotent to abemaciclib and their AUCs accounted for 25%, 13%, and 26% of the total circulating analytes in plasma, respectively.
Excretion: Approximately 81% of the dose was recovered in feces and approximately 3% recovered in urine. The majority of the dose eliminated in feces was metabolites.
Avoid concomitant use of ketoconazole. Ketoconazole is predicted to increase the AUC of abemaciclib by up to 16-fold and may lead to increased toxicity.
Reduce the VERZENIO dosage with concomitant use of other strong CYP3A inhibitors. See the full prescribing information linked below for specific dosage modifications. Patients should avoid grapefruit products. Concomitant use with itraconazole (predicted) or clarithromycin (observed) increased the relative potency adjusted unbound AUC of abemaciclib and its active metabolites by 2.2-fold and 1.7-fold, respectively.
Avoid concomitant use of strong CYP3A inducers and consider alternative agents. Rifampin decreased the plasma concentrations of abemaciclib and its active metabolites by 67% and may lead to reduced activity.
No dosage adjustment is needed for age (range 24-91 years), sex, body weight (range 36 175 kg), mild to moderate renal impairment (CLcr ≥ 30-89 mL/min, estimated by Cockcroft-Gault [C-G]), and mild to moderate hepatic impairment (Child-Pugh A or B). The pharmacokinetics of abemaciclib in patients with severe renal impairment (CLcr < 30 mL/min, C-G), end stage renal disease, or in patients on dialysis is unknown.
Reduce the VERZENIO dosing frequency to once daily in patients with severe hepatic impairment (Child-Pugh C). The relative potency adjusted unbound AUC of abemaciclib and its active metabolites in plasma increased 2.4-fold in subjects with severe hepatic impairment.
Efficacy and Safety
Efficacy of VERZENIO in combination with fulvestrant was demonstrated in a randomized, placebo-controlled, multicenter study of 669 women with HR-positive, HER2-negative metastatic breast cancer in combination with fulvestrant in patients with disease progression following endocrine therapy who had not received chemotherapy in the metastatic setting. Additional information regarding efficacy studies can be found in the full prescribing information linked below.
The most frequently reported (≥ 5%) Grade 3 or 4 adverse reactions in patients receiving VERZENIO plus fulvestrant were neutropenia, diarrhea, leukopenia, anemia, and infections. Severe (Grade 3 and 4) neutropenia was observed in patients receiving VERZENIO as monotherapy. Most common adverse reactions (incidence ≥ 20%) were diarrhea, neutropenia, nausea, abdominal pain, infections, fatigue, anemia, leukopenia, decreased appetite, vomiting, headache, and thrombocytopenia.
Full prescribing information for VERZENIO is available at https://go.usa.gov/xnqNn.
Full prescribing information for fulvestrant is available at https://go.usa.gov/xnqP9.
Visit Drugs@FDA at http://go.usa.gov/cMsjT for prescribing and patient information, approval letters, reviews and other information for FDA-approved drug products, which are often available shortly following approval.
A non-comprehensive list of examples of clinical substrates, inhibitors and inducers for metabolic and transporter system related interactions may be found at https://go.usa.gov/xXY9C.
Healthcare professionals should report all serious adverse events suspected to be associated with the use of any medicine and device to FDA's MedWatch Reporting System by completing a form online athttp://www.fda.gov/medwatch/report.htm, by faxing (1-800-FDA-0178), or by mailing the postage-paid address form provided online, or by telephone (1-800-FDA-1088).
We always welcome your thoughts regarding the format, content, and utility of the communication. Comments may be sent via email to ocp@fda.hhs.gov.
This communication was prepared by Office of Clinical Pharmacology, Office of Translational Sciences, CDER, FDA.


When BBC Calls, Don't Answer..
Focus Politics When BBC Calls, Don't Answer..
That is, don't answer, if you are a certified critic of Israeli policies and practices.
The siren lure of big time media is partly a romancing of the ego, partly a rare moment to intrude a moment or two of truthfulness into the endless spinning of the Israel's narrative that stresses its extravagantly humane response to Hamas flurries of rockets and alleged human shield tactics.
Four times in the past week I have received invitations to be a guest on BBC programs dealing with Israel's military operations in Gaza. Each time the female producer, with charming British intonation, expressed her strong interest in arranging my participation at such and such a time. And each time I agreed, although my presence in a Turkish village with limited Internet access made it logistically awkward to do so, yet far from impossible to make the necessary arrangements, usually with the kind cooperation of a neighbor with superior digital facilities.
Each time I was ready at the appointed hour, and each time I was given a last minute explanation for why my appearance was cancelled—a couple of times I was told that I was a casualty of 'breaking news,' and the other two times, there was no embellishment, merely "we apologize, but we have to cancel today's appearance." And on each occasion, as if part of how producers are trained, I was told that those in charge of planning the program were eager to have me appear as soon as possible, and that I would hear in a day or so. On the basis of my past experience on the few occasions when such last minute news altered programming, I was shifted to later in the program or rescheduled for the next day. My BBC experience in this respect was 'terminal' as in disease.
Needless to say, the phone lines have been quiet since each of these 'dumping' incidents. I wonder why this pattern of invitation and cancellation. I am quite sure that these were quite separate programming for each of the invitations with no coordination among them. Was there some master censor at the BBC that reviewed the guest list just prior to the scheduled broadcast, somewhat in the manner that the way an ethical submarine commander might review the manifest of an enemy passenger ship in time of war? Perhaps, BBC was rightly concerned that there might be a faint and ugly stain of balance that would tarnish their unsullied reputation of pro-Israeli partisanship. I will probably be forever reliant on such conjectures.
I feel self-conscious relating this little saga at a time when so many in Gaza are dying and bleeding, and all are grieving. As I write I feel humble, not arrogant. It seems that somewhere buried in these trivial rejections there is occasion for concern that the media claim of objectivity in liberal societies is above all else a sham. That even powerful players such as BBC are secretly captive, and its reportage and commentary qualifies less as news than as Hasbara, at least when it comes to Israel-Palestine.
In any event, my advice to the media savvy, is that if you have caller ID, and you can tell that it is BBC calling, don't bother answering. I hope I have the good sense to follow my own advice should the phone ever ring again!


Adidas Canada continues to be a significant supporter of Team Unbreakable which means 2019 is already off to a great start! The company is donating funds for our charity, based on an internal company challenge to seek out a deserving Canadian charity with whom employees could also support in giving back to their community. "We're so pleased that adidas chose Team Unbreakable to work with. We're grateful for the financial contribution and we look forward to seeing adidas employees volunteering at various programs in the GTA," says Team Unbreakable Chair Bob Wordham.
Judy and Bing head up the school volunteer program for the company while Anna and Helen head up an adidas commitment to take some of the awarded money to grow it into a larger contribution to Team Unbreakable. Some initiatives have been discussed an a further announcement could be made in the near future. Judy made the first connection with Team Unbreakable as she was volunteering with the Trillium Health Care run-therapy program as a coach.
As a special bonus, adidas donated a run of T-shirts with their motivating slogan, "Through Sport We Have The Power To Change Lives," that rings true to the Team Unbreakable philosophy of physical health for mental health. These shirts have been sold at Team Unbreakable running events.
Feature Picture HomePage: Ian Brown, Carl Worrell, Bob Wordham.