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Race to the Factory of the Future
FANUC-Cisco vs. KUKA-Huawei: Two superbly matched teams making a full-scale assault on The Fourth Industrial Revolution
There's bigger game afoot
Okay, the world knows that China and Japan are competitors; fierce rivals is more like it.
Japan snagged the 2020 Summer Olympics; then China grabbed off the 2022 Winter Olympics. Both pledge to be the world's best in robotics by 2020 and 2022 respectively.
That's a stretch for both…unless each gets a booster rocket to the future.
Luckily for each, a much bigger and more important competition is quickly showing itself to both of these nations; it's a competition that makes just being "the world's best in robotics" pale by comparison.
The competition is the race to the Factory of the Future. To the victor will come solutions to the many problems of economy and society that weigh on each today.
As 2016 dawned, neither China nor Japan was prepared to meet this looming future, yet both desperately needed to.
Suddenly, both are now positioning themselves to not only participate in that bright future, but to lead it.
Here's how.
This is going to get very interesting
Two world-class, high-tech teams are going to duke it out in Asia for supremacy and domination in the global race for the Factory of the Future.
The teams are made up of four of the most unlikely partners; unlikely, not because of their technology, but unlikely because no one saw them coupling up together so fast and so ardently
FANUC-Cisco
One of the teams has a head start. That's the FANUC-Cisco team (Japan and US) and already that team is changing the concept of what goes on in a factory.
This is a game-changing moment for Japan, its economy, its electronics, its people and its pride…and just in the nick of time!
For Cisco, the partnership offers it unprecedented access to the new tools that will be getting hooked up in factories everywhere as the Industrial Internet of Things (IIoT) swings into position.
One half of the Japan-US team is FANUC, the world's largest maker of industrial robots and owner of a 65 percent market share in computer numerical control systems.
The other half of the team is Cisco Systems, the largest networking company in the world, over whose equipment some 80 percent of the world's Internet traffic is carried.
Last week the Nikkei Asian Review's article Fanuc seeks to connect factory machinery of all makes set out the plan, writ large:
"Fanuc hopes to create a system that can control the operating states of every piece of machinery on the factory floor, including robots, machine tools and other equipment made by other companies.
"The Japanese manufacturer of factory automation equipment has teamed with Cisco Systems, a U.S. maker of communications network equipment, and others to develop the system. They hope to have it ready as soon as this fall for use in factories."
KUKA-Huawei
After a quick trip across the Sea of Japan, keep an eye out for the KUKA-Huawei team (Germany and China). The team will be difficult to spot because the two constituent parties that make up the team are lagging a bit behind.
Germany's KUKA, the world's fourth largest industrial robot maker, is in the final dance moves of being acquired by Chinese appliance maker, Midea for $5 billion.
No sane person in the robotics business believes for an instant that Midea is capable of properly managing KUKA. Midea is more of a proxy buyer of KUKA; the real management team will end up being a tripartite group made up of KUKA staff, Siasun staff (China's best industrial robot maker), andHuawei staff.
Huawei Technologies is a Chinese multinational networking and telecommunications equipment and services company. It is the largest telecommunications equipment manufacturer in the world.
Huawei will be for China what Cisco is for Japan: the grand seamstress that knits Information Technology and communications into a single factory to enable IIoT, and then to knit a geography of factories together into a grand quilt of interoperation that has come to be known as the Fourth Industrial Revolution.
There's lots of bad blood between Huawei and Cisco as each has fought the other for market share and in courts over patents; the only scuffle not attempted yet by the pair is a tong war.
With 70,000 R&D engineers out of a total head count of 140,000, Huawei is well-positioned to innovate its way into being the networking partner to KUKA's deep knowledge and expertise with industrial robotics.
The speculation game
Stretched out before the KUKA-Huawei team are tens of thousands of Chinese factories awaiting elevation into the IIoT world. Beyond that are the ASEAN nations to the south, and westward to Central Asia deep along the Silk Road, and then on into Eastern Europe.
The rewards for success will be beyond spectacular.
What for KUKA or Huawei separately would be totally unthinkable, together is eminently possible. Especially with China's massive bankroll behind it and cart blanche to any and all factories and warehouses anywhere in the People's Republic.
With robotics high on the to-do list of this the 13th Five-Year Plan (2016-2020), with robotics getting the personal backing of President Xi Jinping, it's a no-brainer the kind of access the KUKA-Huawei team will have
Publicly traded KUKA stands to make billions as the exclusive high-end robot maker in China. Huawei, still private, might well think hard about going public when it starts to wire up China's factories with KUKA. There could well be a vast fortune awaiting the exchange of its shares for cash.
What China knows…and what it fears
China is well-aware of the FANUC-Cisco team; and well-aware also of its own need for high-end robotics technology and a steady supply of top-notch robot parts. It can't possibly hope to compete with Japan without immediate upgrades in those areas.
Before KUKA, Midea was in discussions with Japan's Yaskawa, another of the Big Four in robotics (FANUC, Yaskawa, KUKA, and ABB). The Japanese were polite but non-committal; not wanting, more than likely, to offend China (via Midea) where it does millions of dollars of annual business.
The courtship ended quickly, but not before Midea announced two smallish joint ventures with the Japanese robot maker to build service and industrial robots.
Midea moved on.
China knew that it had to move quickly or the FANUC-Cisco team would quickly and completely out maneuver it. It could well end up with the unthinkable: FANUC-Cisco outfitting China's Factories of the Future…at a very steep price.
That hunt ended just as quickly at the doorstep of KUKA in Augsburg, Germany.
Midea already owned 5 percent of KUKA, but now wanted to exchange $5 billion for the other 95 percent. KUKA agreed.
China must now hustle the team-making part of things and get the KUKA-Huawei team into play.
Quick backstory: Japan
If you want the world's best robots for your factory, check in with Japan; the emperor of all robots has six of the top eight robot makers.
However, if on the hunt for IT, software or networking communications, best look elsewhere.
As the Japan Times put it: "Japan's manufacturing sector is lagging behind other countries in utilizing information technology, according to an annual government report that called for improvements."
And worse: "The report said Japanese manufacturers were not utilizing so-called "big data," or the tremendous amounts of data accumulated online…According to a survey, 70 percent of Japanese firms were not using or had never heard of the concept."
Never heard of it!! Yikes!
Things get worse when hunting for microprocessor design, microprocessor architecture and semiconductor fabrication technology.
But lo and behold, Masayoshi Son, Chairman and CEO of Japan-based SoftBank just scooped up (July 18) British chip designer ARM Holdings for more than $32 billion.
Fancy that.
The sale represents a 43 percent premium over ARM's share price at the Friday close.
Think SoftBank wanted that badly enough?
Japan's traditional wheelhouse
FANUC, Cisco, and now ARM show a massive move of technology right into Japan's traditional wheelhouse of excellence, which says: Give us a piece of technology, and we'll transform it into something you never in your wildest dreams thought possible.
Japan has pulled off that feat with automobiles, computers, robots and electronics.
See Part 2 of 3-part article series: Team Japan: Empire of Canary Yellow
See: Part 3 of 3-part article series: China Responds: The Long March at a Quick Pace


Sarah Johnson is a Partner in Piper Alderman's Commercial team.
Sarah is an experienced lawyer with particular expertise in general commercial law, private mergers and acquisitions, private equity transactions, corporate governance and structuring, information technology, intellectual property and not for profit law. She has advised large privately held companies, listed companies, private equity investors including high net wealth individuals, peak group organisations and not for profit organisations in relation to all aspects of corporate and commercial law. Sarah also regularly acts as company secretary for her clients, including advising on Corporations Act and ASX Listing Rule compliance.
Sarah has practised for over 18 years, initially in New Zealand, and for the last 13 years, in Sydney, Australia.
Sarah is a specialist in legal issues arising in a wide variety of industries, including heavy industry, biotech, renewable energy, emerging technologies, manufacturing, FMCG and not for profit sectors.
She has a wealth of transactional experience, providing bespoke legal solutions in respect of a wide variety of complex corporate and business matters.


January 22, 2014 E-mail this page to a friend!
Go beyond the classroom with UC Davis Extension's Summer Horsepacking Adventures.
This deluxe, seven-day pack trip covers the essentials of horsepacking with the Golden Trout Wilderness of the High Sierra as your laboratory. Past participants have acclaimed it as an outstanding adventure. The instructors will discuss equipment, emergency veterinary care, feeding and managing livestock in the backcountry, and more.
Spend four days observing and photographing the free-roaming herds, blooming wildflowers and other resident wildlife. Enjoy awe-inspiring vistas with their rugged beauty and stunning mountain sunsets. Experienced guides and instructors will lead evening discussions on the history, social behavior and uncertain future of these proud animals. While this adventure is open to any level rider, be prepared to ride three to six hours a day with a break for lunch. The group will operate from a base central meadow camp and ride out each day to open range.


MEIRELES, B.; GASPAR, D.; USIÉ, A.; BARBOSA, P.; SCOTTI, P.; SEMEDO, J.; PAIS, I.; MAÇÃS, B.; ALMEIDA, A.S.; COSTA, R.; COUTINHO, J.; PINHEIRO, N.; MATOS, J.; SIMÕES, F.; MENDONÇA, D.; GUIMARÃES, J.; RAMOS, A.M. (2017). "Identification of miRNAs related with the response to heat stress in two Triticum durum varieties". 6th Bioinformatics Open Days. February 22nd – 24th 2017, Braga, Portugal.


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The Slatest
R. Kelly Accused of Bribing Official for Fake ID to Marry 15-Year-Old Singer Aaliyah
By Elliot Hannon
Dec 06, 20195:59 AM
Singer R. Kelly at a court hearing in Chicago on Sept. 17.
Pool/Getty Images
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Federal prosecutors hit singer R. Kelly with another charge Thursday, accusing the 52-year-old of bribing an Illinois state official in 1994 to get then-15-year-old singer Aaliyah a fake ID saying she was 18 in order to marry her. Kelly was 27 years old when he married the underage singer whose album he also produced. The latest charge against the disgraced singer is part of an expansion of an existing racketeering indictment in New York, the New York Times reports, which adds to the more than a dozen federal and state charges facing the singer, ranging from producing child pornography and kidnapping to forced labor and failing to disclose an STD to sexual partners.
Kelly married Aaliyah on Aug. 31, 1994, according to the marriage license, which is a day after Kelly is alleged to have paid a bribe for her fake ID. Earlier that year, Aaliyah released her first album titled Age Ain't Nothing but a Number, which was produced by Kelly, and later went platinum. The marriage was later annulled and Aaliyah died in a plane crash in 2001 at 22. The indictment undermines Kelly's already pretty far-fetched contention that he did not know Aaliyah, then a high school student, was underage at the time. "My understanding is that she did not claim to be 15, and in order to get married, she had to lie about her age," a lawyer for Kelly told ABC's Good Morning America earlier this year. "He was married to her when she was 15. Elvis was married to Priscilla," the lawyer said, shrugging off the allegations.
This latest 25-year-old charge against Kelly, which like many of the accusations made against the singer, would normally fall outside the statute of limitations for such crimes, but is being pursued by prosecutors as part of a broad racketeering prosecution. Pursuing a racketeering charge, normally used to go after the mob, "where [Kelly] is accused of leading a criminal enterprise that recruited his fans, sometimes underage girls, to have sex with him—allows prosecutors to introduce acts from any time period that were part of the alleged conspiracy," the Times notes. "His associates arranged for the travel and lodging of his sexual partners. But once they arrived, prosecutors said, the women had to follow strict rules. They were not allowed to leave their room without Mr. Kelly's permission and had to call him 'daddy.' They were isolated from their friends and families, making them financially dependent on Mr. Kelly, the indictment said."
Criminal Justice R. Kelly
Elliot Hannon is a Slate staff writer.

redpajama_set_name: RedPajamaCommonCrawl


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Home / News / FAO launches a manual to guide nutrition-sensitive programming in agriculture
FAO launches a manual to guide nutrition-sensitive programming in agriculture
Thuy | Global initiativesMulti-stakeholder planningResearch	SUN UN Network 0
In November 2015, the Food and Agriculture Organization (FAO) launched a new manual titled "Designing nutrition-sensitive agriculture investments. Checklist and guidance for programme formulation". The manual is designed to guide programme planners in the design of nutrition-sensitive programmes.
Increasingly, institutions investing in food systems have committed themselves to ensuring their investments are "nutrition-sensitive", but many professionals from the food and agriculture sector seek guidance on what this entails in terms of programme design and implementation.
In November 2014, during the Second International Conference on Nutrition (ICN2), FAO and World Health Organisation (WHO) Member States reaffirmed their commitment to combat all forms of malnutrition through the adoption of the Rome Declaration on Nutrition and its Framework for Action. The ICN2 Framework for Action emphasizes the importance of "reviewing national policies and investments and integrating nutrition objectives into food and agriculture policy, programme design and implementation".
That is why FAO, in consultation with civil society, governments, donors, UN agencies, and particularly the Agriculture to Nutrition Community of Practice (Ag2Nut), has developed a set of 10 Key Recommendations for Improving Nutrition through Agriculture. The manual is designed to serve as a tool to guide programme planners who are aiming to apply these recommendations in the design of agricultural investments and programmes.
10 Key Recommendations English | Français | Español
The manual has been developed with the notion that the strategies that will enable an agriculture investment to be "nutrition-sensitive" are context-specific and require continuous revision. The checklist does not, therefore, provide "answers" but questions and tips, which can guide practitioners in finding the most locally appropriate solutions to complex challenges. Tips are primarily sourced from the "Synthesis of Guiding Principles on Agriculture Programming for Nutrition" (FAO, 2013).
Complementary FAO publications
This manual will be complemented by two other FAO publications to be published early 2016
The Compendium of Food and Agriculture Actions for Nutrition: This compendium will provide a list of interventions related to crop production, horticulture, livestock, fisheries, food processing, forestry and nutrition promotion, which can contribute to improving nutrition as part of a multi-sectoral strategy.
The Compendium of Indicators for Nutrition-Sensitive Agriculture: This document will describe a range of indicators, which can be used to monitor and evaluate the nutrition-related impacts of investments in agriculture and rural development.
Learn more about "Designing nutrition-sensitive agriculture investments. Checklist and guidance for programme formulation"
Climate SUN Movement Executive Committee N4G Global initiatives Peer-to-peer learning Nutrition commitments Theory of Change Investments Environment Adolescent nutrition Multi-stakeholder planning SUN Movement Secretariat Women's empowerment Business SUN 3.0 COVID19 Policies & laws Women's nutrition Private sector Advocacy


The Energy Saving Trust is proud to present the first UK event for 'Premium Light Pro', in collaboration with the Lighting Industry Academy.
The Premium Light Pro initiative focuses on the implementation of next-level energy efficient LED lighting systems (indoor and outdoor) in both the public and private sector. The main target of this programme is to support the implementation of high quality and efficient lighting solutions by appropriate instruments and services.
This one day training session, aimed at the SME sector, will be delivered by the Lighting Industry Academy and aims to offer support for the implementation of indoor lighting systems and enable attendees to understand, specify and procure high quality lighting for their business or organisation. The training will target design, technology, management and funding issues and address the major barriers and challenges for improving lighting, with a focus on LED solutions. The training day will also feature a tour of the LIA's testing laboratory to enable attendees to understand some of the testing that lighting products undergo.
Upgrading lighting in non-domestic premises offers a huge energy and cost saving opportunity for both individual businesses and our national energy demand as a whole. With the commercial sector accounting for 70% of lighting energy demand, it's estimated that around 14 billion kWh could be saved through low-energy lighting – around the same amount produced by a nuclear power station. And when polled by The Grocer as part of the 2015 'Switch the Lights' campaign, 85% of businesses who had already made the jump to LED reported that this had caused "highly beneficial" or "beneficial" savings to maintenance budgets.
This training course is suitable for a wide audience, including staff with no previous knowledge or experience with lighting. In particular it will be useful to SME owners and staff that have an interest in lighting, or are responsible for making decisions on lighting and considering upgrades in the near future, as well as installers and designers working in this capacity.
For more information about Premium Light Pro, please visit – http://www.premiumlightpro.org.uk or follow @PremiumLightPro. For more information about event, please contact jim.cardy@est.org.uk.
This cost has been subsidised by the Horizon 2020 Premium Light Pro Programme and includes lunch and refreshments. Spaces are limited to 20, so book early to avoid disappointment.


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Report that Roy Moore had sexual contact with a teen raises questions about his Senate run
Nov 9, 2017 6:50 PM EDT
https://www.pbs.org/newshour/show/report-that-roy-moore-had-sexual-contact-with-a-teen-raises-questions-about-his-senate-run
Roy Moore, the Republican frontrunner for a U.S. Senate seat in Alabama, is engulfed in a scandal over reports that he had sexual contact with a 14-year-old in his early 30s, and approached other teens for dates. Moore has denied the allegations. Judy Woodruff learns more about the claims and fallout from Beth Reinhard of The Washington Post and Don Dailey of the Alabama Public Television.
Judy Woodruff:
The Republican front-runner for a U.S. Senate seat in Alabama is engulfed in a sexual scandal tonight, one month before a special election.
The Washington Post reports that Judge Roy Moore had sexual contact with a 14-year-old girl when he was in his early 30s. Three other women say that Moore also approached them when they were teens. Moore is now 70. His campaign called the claims outlandish attacks.
But top Republicans took a dim view, including Alabama's current U.S. senators, Richard Shelby, and Luther Strange, who lost to Moore in a Republican primary this fall.
Sen. Luther Strange:
They have just come to light, and I have just read about it. And it's very, very disturbing what I have read about.
Sen. Richard Shelby:
It's a devastating, nasty story. If the revelations, if that's true, then I don't believe there'd be any place for him in the us Senate.
The Senate's top Republican, Mitch McConnell, also weighed in with a statement saying, simply, "If these allegations are true, he must step aside."
I spoke a short time ago to one of the reporters who broke this story, Beth Reinhard of The Washington Post, as well as to Don Dailey, who covers politics for Alabama Public Television.
We began with how the allegations first surfaced.
Beth Reinhard:
So The Post was in Alabama reporting an unrelated story and heard that Roy Moore had pursued young girls when he was first a prosecutor.
And another reporter and I spent weeks in Alabama chasing these leads and reaching out to a lot of people. And when we did reach the women who are quoted in the story today, none of them initially were willing to speak on the record. They were all very reluctant to share their story publicly, and it was only after multiple interviews with them that they decided to come forward.
Well, let me ask you first, Beth Reinhard, about the woman who was youngest, I guess, of all of these when this happened. She was 14 years old at a time when Roy Moore was an assistant district attorney. He was in his early 30s. And what does she say happened?
So, she was at the courthouse with her mom for a child custody hearing.
And Roy came up and introduced himself and offered to watch her while her mother went into the courtroom. He got her phone number. He called her. He picked her up a few days later around the corner from her house, and took her to his house, which is in a woodsy area about 30 minutes away, gave her alcohol, and then, on one occasion, undressed himself, undressed her and touched her over her bra and underwear, and had her touch him.
And you report that she told a friend at the time this happened, and then she told her mother years later?
She told a couple of friends at the time, and they were — you know, reacted sort of negatively, like, that's not a good idea.
And so she felt ashamed about it, she felt responsible about it. She just sat with it for many years. She is told her mom when she was an adult, and then, even then, thought about coming forward, but didn't. She had kids that she was worried about, and it just — it really took a lot of time for her to feel comfortable with her decision.
And, Beth, just quickly, the other three women alleged what?
So, they were a little bit older. They were between the ages of 16 and 18, and they say that Roy asked them out on dates, and two of the three did go out with him. They say he didn't force himself on them.
But, looking back, they realized it was really inappropriate for him, a man in his 30s, to be asking out teenage girls that he met at the mall or in one case at a high school civics class where he was speaking to her class.
Don Dailey, what is Roy Moore saying about all of this?
Don Dailey:
Roy Moore issued a statement today in which he staunchly denied these allegations. He called them the result of fake news and he said they were designed to attack him politically.
Roy Moore has been at odds with The Washington Post for a month or so now. He's been upset about a previous news story concerning his charitable organization, the Foundation for Moral Law, and The Post's reporting on that.
And that on top of these new allegations has led him to believe that this latest piece is a hit piece. But, again, he has staunchly denied these allegations.
And, Don, what does Alabama law say about relations, sexual relations with a minor?
We have been checking this afternoon with various officials about what this might mean.
A lot of people are still saying that they're looking into the consequences of these allegations and the statute of limitations, those sorts of things.
And another aspect of the law that's been debated here in Alabama this afternoon is, could Roy Moore's name possibly be removed from the ballot, if it came that far? And the secretary of state has said this afternoon that state law says it has to be under 76 days from the election before you can remove a name from the ballot.
So, the secretary of state here in Alabama said it is too late to remove Roy Moore's name, should it come to that.
Don Dailey, how are others in Alabama reacting to this, and were there any indications of this before this story?
There were not any indications of this.
I think a lot of people were caught by surprise here in Alabama. Some of Roy Moore's defenders have actually raised the contention, why didn't this come out a long time ago, why is it now just surfacing? Because Roy Moore has been such a public figure here in Alabama for so long. Why is it just coming out now?
But a lot of people are surprised. A lot of people are reacting rather guardedly, saying if these allegations prove to be true, that Roy Moore should step down as a candidate. Others are staunchly defending him, especially his base.
Roy Moore enjoys a staunch base of supporters here in Alabama, Republicans, conservatives, evangelical Christians who have stood by him through thick and thin through a lot of controversies that he has weathered here in Alabama over the years.
Beth Reinhard, is it fair to say The Post is still reporting on this, continuing to report on this?
I mean, we will obviously be keeping an eye on Roy Moore as a candidate through Election Day and beyond that if he's elected a senator.
And, right now, Don Dailey, what are the polls showing, that Roy Moore is ahead, by how much?
The latest polls have him up by double digits, and he has maintained that sort of lead for the last several weeks, since the Republican runoff election here in Alabama.
A lot of people are waiting with bated breath now to see what kind of impact these allegations might have on his poll numbers. But, again, his base of support here has been very strong and those who support him most don't think that it will have a significant impact because they don't believe the allegations.
And, Don, no hint that he's prepared step down, back off from running, right?
He has made no indication so far that he plans to step down.
Don Dailey with Alabama Public Television, Beth Reinhard with The Washington Post, thank you both.
PBS NewsHour from Nov 09, 2017
Alabama's Roy Moore should step aside if sexual allegations are true, McConnell says
What Moore's win in Alabama means for Trump and the GOP
By Daniel Bush


One of France's historical places, Notre Dame Cathedral located in the French capital caught fire Monday evening and is at least partially destroyed.
Several videos and photos going viral on social media revealed flames engulfing the church, before both the ceiling and the 90-meter (295 feet) spire collapsed, drawing gasps and moans of disbelief from witnesses.
Investigators disclosed there were no deaths and it is unclear if there were any injuries. The fire broke out just before 7 p.m., minutes after the cathedral closed to the public. Around 30,000 people visit the church daily.


Customer Service Team Leader Kristina Diaz, #741, Orlando, Florida, had two options to treat her stage 5 kidney failure: a transplant or eight to nine hours of daily dialysis.
At that stage — also known as end-stage renal failure — Kristina's kidneys were functioning at only 15 percent capacity. The waitlist for a transplant was anywhere from eight to 10 years. Without dialysis, the process of filtering and purifying blood through the help of a machine, Kristina was told she may only survive a month. Maybe less.
With failing health and a young daughter to care for at home, Kristina had to take time off from work to undergo treatments. She began her mornings at 5 a.m. to travel to her neighborhood clinic to begin dialysis.
"It made me so weak. I had to be carried back to my car," she said.
As she adjusted to her new way of life, she transferred to #331, Orlando, Florida, to be closer to home. There, she met Seafood Specialist Eric Chandler. Soon after, they started dating.
A few months later, Kristina was forced to stop dialysis because of an infection. As her health declined, her need for a transplant became more critical. Eric decided to get tested to see if he could be her donor. They were warned the chances were slim — donors often need to be blood relatives of the recipient. Still, Eric insisted.
Eric and Kristina underwent surgery for the transplant in late August.
"The kidney started working instantly," said Kristina.
While they were out, they received help with living expenses from their fellow Publix associates and United Way.
Kristina is thankful for Eric, his kidney donation and the help she received from her Publix family. She's also thankful for finding the will to persevere.
"I feel incredible. This journey reaffirmed my faith and reminded me not to take things for granted," she said.


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Volume 4 Supplement 1
Stem cells on bioengineered microphysiological platforms for disease modeling and drug testing
The National Institutes of Health Microphysiological Systems Program focuses on a critical challenge in the drug discovery pipeline
Margaret L Sutherland1,
Kristin M Fabre2 &
Danilo A Tagle2
Stem Cell Research & Therapy volume 4, Article number: I1 (2013) Cite this article
The National Institutes of Health has partnered with the US Food and Drug Administration and the Defense Advanced Research Projects Agency to accelerate the development of human microphysiological systems (MPS) that address challenges faced in predictive toxicity assessment and efficacy analysis of new molecular entities during the preclinical phase of drug development. Use of human MPS could provide better models for predicting the efficacy of new molecular entities in clinical trials. It is also anticipated that improvements in predicting drug toxicities early in the drug development process through the use of MPS or human organs-on-a-chip will decrease the need to withdraw new therapies from the market and minimize or eliminate deaths due to unidentified drug toxicities.
Challenges in moving promising new drugs to the marketplace
Although advances in basic and preclinical science continue to fuel the drug discovery pipeline, only a small fraction of compounds in the pipeline meet criteria for approval by the US Food and Drug Administration (FDA) [1]. Current success rates for compounds that reach phase II and phase III clinical trials have dropped to 18% and 50%, respectively [2, 3], with failures in the clinic and removal prior to FDA review being attributed to a lack of efficacy, unidentified toxicities in the preclinical phase, and an ever-changing business strategy for some of the drug developers [2, 3]. Since the drug discovery pipeline is both labor and resource intensive, alternative approaches that would enable early indications and potentially more reliable readouts of toxicity or efficacy could provide significant improvements in the success rate and associated cost benefits for this process. To address this challenge in drug development and regulatory science, the National Center for Advancing Translational Sciences (NCATS), through the Cures Acceleration Network and in conjunction with the National Institutes of Health (NIH) Common Fund, has invested $70 million over a 5-year period to launch the Microphysiological Systems (MPS) Program or Organs-on-Chips Program.
The NIH Microphysiological Systems Program targets novel human cell-based systems for predictive drug toxicity
The NIH MPS Program is part of a coordinated effort between the NIH, the Defense Advanced Research Projects Agency (DARPA), and the FDA to accelerate the development of human MPS that will improve the reliability to identify human drug toxicities and predict the potential efficacy of a drug in a human population prior to use of the drug in late-stage clinical studies. While the NIH and DARPA independently fund and manage their own MPS programs, coordination of these programs occurs through biannual meetings with NIH and DARPA investigators. These meetings provide opportunities not only to share advances in platform development, cell source characterization, but also to establish collaborations that will help accelerate the development, validation and integration of robust human MPS.
The goal of the NIH MPS Program is to create and integrate MPS that utilize human primary or stem cell sources, which are sustainable over a 4-week period and functionally represent the 10 major organ systems: circulatory, respiratory, integumentary, reproductive, endocrine, gastrointestinal, nervous, urinary, musculoskeletal, and immune. The 19 investigators funded under the MPS Program are supported through 2-year (Table 1) and 5-year (Table 2) cooperative agreements, where annual milestones determine the successful progression of each project. The MPS cooperative agreement mechanism also facilitates monthly reviews of progress on individual projects where scientific program staff, representing 15 NIH institutes, provide advice on system metrics and assist in the identification of available resources that can help achieve the aggressive timelines of the program. To further serve the objectives of the cooperative agreement, the MPS Program has implemented a communications interface sponsored by NCATS, which is design to facilitate information exchange and the development of MPS organ and cell source standards among the investigators.
Table 1 The U18: 2-year funded National Institutes of Health Microphysiological Systems Program investigators
Table 2 The UH2/UH3: 5-year funded National Institutes of Health Microphysiological Systems Program investigators
The concept of developing standards around the microphysiological organ systems under development by NIH investigators is driven by the need to provide a MPS consensus view on the minimal functional requirements of a system to accurately mimic the function of the human organ. A similar approach is being applied to the induced pluripotent stem cell sources being utilized in MPS development, wherein any induced pluripotent stem cell source must: demonstrate a normal karyotype; be free of bacterial and mycoplasma contamination; demonstrate expression of stem cell markers; demonstrate successful silencing of transgenes used in the reprogramming phase; and have the ability to differentiate along mesoderm, ectoderm and endoderm germ layer lineages. Through the development of MPS and cell source standards, collaborations and information exchange, it is anticipated that within the next 5 years the collective efforts of the NIH grantees will culminate in MPS that will provide improved research tools for efficacy and toxicology screening of new molecular entities.
To evaluate the potential improvement MPS provide over traditional in vivo animal toxicology, a set of training compounds has been selected based on known toxicities in the human population. This training set of compounds addresses organ-specific toxicities that will be tested across the various MPS platforms. A second set of drugs, where the identity is blinded to the investigators, will be used for validation to ensure an unbiased evaluation of the reliability and predictability of these systems. The global application of MPS in new drug toxicity and efficacy testing, and recognition of these systems by regulatory agencies such as the FDA, will require coordination with standards agencies like the International Conference on Harmonization. The International Conference on Harmonization has developed a comprehensive set of safety guidelines to uncover potential risks such as carcinogenicity, genotoxicity and reprotoxicity, and these safety guidelines have been adopted by international regulatory agencies.
Defense Advanced Research Projects Agency and US Food and Drug Administration
To provide advanced engineering and platform development that will support the integration of 10 human organ systems onto a single platform with a biofluidics infrastructure that can link the various organ systems, a parallel and complementary effort to the NIH MPS Program is funded by DARPA. Dr Linda Griffith (Massachusetts Institute of Technology, MA) and Dr Don Ingber (Wyss Institute, Harvard University, MA) are DARPA investigators tasked with the stepwise integration and validation of 10 human organ systems onto a shared platform that supports the viability of the integrated systems for a 4-week period. Like the NIH MPS Program, the DARPA Program represents a 5-year, $75 million commitment.
As defined in a memorandum of understanding between the NIH and the FDA, for the NIH MPS Program the FDA provides key guidance for development of robust compound libraries and physiological readouts that reflect toxicities both within a single organ system and across multiple organ systems.
Why animal models can fail
The challenge of accurately predicting drug toxicities and efficacies is in part due to inherent species differences in drug metabolizing enzyme activities [4, 5] and cell type-specific sensitivities to toxicants [5]. For example, a dramatic difference between rat and human drug metabolism is demonstrated by the metabolism of coumarin. Species differences in coumarin toxicity appear to be mediated through two major phase I metabolic pathways. The first involves the conversion of coumarin by cytochrome P450 CYP2A enzymes to the nontoxic metabolite 7-hydroxycoumarin. Whereas in humans this reaction is very efficient, in rats CYP2A enzymes preferentially catalyze 7α-hydroxylation of testosterone rather than coumarin 7-hydroxylation [6] and therefore the formation of 7-hydroxycoumarin is extremely low in rats and the lack of 7-hydroxycoumarin is thought to render rats more susceptible to hepatotoxicity [7]. The second pathway involves detoxification of the epoxide intermediate coumarin 3,4-epoxide. In humans, coumarin 3,4-epoxide spontaneously rearranges to o-hydroxyphenylacetaldehyde, which is further detoxified by oxidation to o- hydroxyphenylacetic acid. In rats, this conversion to o- hydroxyphenylacetic acid is 50 times lower than in humans, and represents a second major species difference in coumarin-mediated heptotoxicity [8]. Certainly, a clear understanding of the role of drug metabolism in toxicity and potential species differences in response to toxic metabolites will aid in the development of safer drugs.
Inherent differences in cell type-specific sensitivities between species may also be an important differentiating factor for the prediction of drug toxicities. An example of differential cell toxicities across species is observed with bizelesin, a potent synthetic derivative of the anticancer agent CC-1065 that preferentially alkylates and binds the minor groove of DNA. Results with myelopoietic cells in vitro, in the absence of liver metabolism, reproduced in vivo species differences in myelosuppression, hence showing that murine cells are 1,000-fold more sensitive than human or canine cells [9]. In the case of the antidiabetic drug troglitazone, metabolism by CYP3A4 and CYP3a1 in human and rat, respectively, results in a reactive quinone intermediate that can bind to proteins and nucleic acids and can potentially produce oxidative stress through the generation of reactive oxygen species via redox cycling or depletion of the oxidative stress protective tripeptide, glutathione. Using rat and human hepatocyte monolayer cultures, Lauer and colleagues demonstrated strong species differences and marked alterations in expressions of genes involved in xenobiotic metabolism as well as oxidative stress after treatment with troglitazone [6]. The higher sensitivity of human hepatocytes towards troglitazone treatment in contrast to the weaker effects observed in rat hepatocytes at least partially explains why the strong hepatotoxic effects of troglitazone in the human population could not be predicted from regulatory animal studies [6]. The results of these in vitro studies suggest that in addition to differences in drug metabolism, target cell sensitivity differences may also account for species differences in toxicity.
A review of FDA-approved drugs released from 1975 to 1999 estimated that 2.9% of these marketed drugs were withdrawn from the market due to severe adverse drug effects [10]. According to Temple and Himmel, hepatotoxicity was the most frequent single reason for removing drugs from the market during this timeframe, and probably will still be the most important single toxicity leading to withdrawal or significant modification of labeling for FDA-approved drugs going forward [11]. Examples of drugs removed from the market due to hepatoxicity during this time period include ticrynafen, benoxaprofen, bromfenac, and troglitazone. In addition to hepatoxicity, six drugs were withdrawn from the market because of hemolytic anemia (nomifensine maleate), hemolytic anemia, renal and hepatic injury (temafloxacin), thromboembolism (azaribine), anaphylaxis (zomepirac sodium), acute but reversible renal failure (suprofen), and increased mortality (flosequinan). Based on estimates from Lasser and colleagues, the probability of a new drug acquiring black box warnings or being withdrawn from the market over 25 years is approximately 20% [12]. Through development of human cell-based MPS, it is hoped that toxicities as mentioned above will be detected earlier, preferably during the preclinical phase of drug development.
Given the list of FDA drugs withdrawn due to unpredicted toxicities in the human population, a key goal of the NIH MPS Program is to accurately evaluate the predictive value of these systems in determining drug toxicity and efficacy. This goal can be achieved through either development of a single microphysiological system, such as a liver organoid system that can reliably predict human hepatoxicity, or through a more complex platform where multiple MPS predict multiorgan toxicities to a given challenge drug. The multisystem platform approach will also assist in understanding the time dependence and magnitude of drug-drug interactions; for instance, how one drug may increase the blood concentration of another, as seen in the effect of mibefradil on midazolam blood concentrations [12]. Understanding the limitations of these model systems will also be important. For instance, in cases where recognition of toxicity in the human population has been delayed - such as seen in the marked hypo tension with clozapine, the pulmonary fibrosis and marrow toxicity with tocainide, the valvulopathy associated with fenfluramine hydrochloride and the subarachnoid hemorrhage associated with phenyl propanol-amine [13] - the application of relatively short-term exposures of drugs in the MPS may limit the predictive value of the system for delayed toxicities.
National Center for Advancing Translational Sciences and the Microphysiological Systems Program
The MPS Program is an excellent flagship program for NCATS, established in 2011 with a mission to catalyze the generation of innovative methods and technologies that will enhance the development, testing, and implementation of diagnostics and therapeutics across a wide range of diseases and conditions. The opportunities for significant advancements in the prediction of human drug toxicities through the development of MPS requires a multidisciplinary approach that relies on an understanding of human physiology, stem cell biology, material sciences and bioengineering. At the end of the 5-year funding period it is anticipated that the availability of these systems to a broader research community will foster a multitude of new research applications including, but not limited to, studies in environment exposures, reproduction and development, infectious diseases, cancer, countermeasures for chemical warfare, immune responses and neuroinflammation.
CYP:
DARPA:
FDA:
US Food and Drug Administration
MPS:
microphysiological systems
NCATS:
National Center for Advancing Translational Sciences
NIH:
National Institutes of Health.
Collins FS: Reengineering translational science: the time is right. Sci Transl Med. 2011, 3: 90-17.
Arrowsmith J: Trial watch: phase II failures: 2008-2010. Nat Rev Drug Discov. 2011, 10: 328-329.
Arrowsmith J: Trial watch: phase III and submission failures: 2007-2010. Nat Rev Drug Discov. 2011, 10: 87-10.1038/nrd3375.
Martignoni M, Groothuts GMM, de Kanter R: Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction. Expert Opin Drug Metab Toxicol. 2006, 2: 875-894. 10.1517/17425255.2.6.875.
Li AP: Evaluation of metabolism-based drug toxicity in drug development. Chem Biol Interact. 2009, 179: 1-3. 10.1016/j.cbi.2008.11.013.
Lauer B, Tuschl G, Kling M, Mueller SO: Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chemico-Biological Interactions. 2009, 179: 17-24. 10.1016/j.cbi.2008.10.031.
Pearce R, Greenway D, Parkinson A: Species differences and inter-individual variation in liver microsomal cytochrome P450 2A enzymes: effects on coumarin, dicoumarol and testosterone oxidation. Arch Biochem. 1992, 298: 211-225. 10.1016/0003-9861(92)90115-D.
Lake BG: Coumarin metabolism, toxicity and carcinogenicity: relevance for human risk assessment. Food Chem Toxicol. 1999, 37: 423-453. 10.1016/S0278-6915(99)00010-1.
Vassallo JD, Hicks SM, Daston GP, Lehman-McKeeman LD: Metabolic detoxification determines species differences in coumarin-induced hepatotoxicity. Toxicol Sci. 2004, 80: 249-257. 10.1093/toxsci/kfh162.
Volpe DA, Tomaszewski JE, Parchment RE, Garg A, Flora KP, Murphy MJ, Grieshaber CK: Myelotoxic effects of the bifunctional alkylating agent bizelesin on human, canine and murine myeloid progenitor cells. Cancer Chemother Pharmacol. 1996, 39: 143-149. 10.1007/s002800050550.
Temple RJ, Himmel MH: Safety of new approved drugs: implication for prescribing. JAMA. 2002, 287: 2273-2275. 10.1001/jama.287.17.2273.
Lasser KE, Allen PD, Wollhandler SJ, Himmelstein DU, Wolfe SM, Bor DH: Timing of new black box warnings and withdrawls for prescription medications. JAMA. 2002, 287: 2215-2220. 10.1001/jama.287.17.2215.
Sekiguchi N, Kato M, Takada M, Watanabe H, Takata S, Mitsui T, Aso Y, Ishigai M: Quantitative prediction of mechanism-based inhibition caused by mibefradil in rats. Drug Metab Dispos. 2011, 39: 1255-1262. 10.1124/dmd.110.037903.
The publication costs for this article were funded by the NIH Common Fund.
Publication of this supplement has not been supported by sponsorship. Articles have undergone the journal's standard review process. The Editors declare that they have no competing interests.
This article has been published as part of Stem Cell Research & Therapy Volume 4 Supplement 1, 2013: Stem cells on bioengineered microphysiological platforms for disease modeling and drug testing. The full contents of the supplement are available online at http://www.stemcellres.com/supplements/4/S1.
National Institute of Neurological Disorders and Stroke, National Institutes of Health, 6001 Executive Blvd., Bethesda, MD, 20892, USA
Margaret L Sutherland
National Center for Advancing Translational Sciences, National Institutes of Health, 6001 Executive Blvd., Bethesda, MD, 20892, USA
Kristin M Fabre
& Danilo A Tagle
Search for Margaret L Sutherland in:
Search for Kristin M Fabre in:
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Correspondence to Margaret L Sutherland or Kristin M Fabre.
Sutherland, M.L., Fabre, K.M. & Tagle, D.A. The National Institutes of Health Microphysiological Systems Program focuses on a critical challenge in the drug discovery pipeline. Stem Cell Res Ther 4, I1 (2013) doi:10.1186/scrt361
DOI: https://doi.org/10.1186/scrt361


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Descriptive essay about a university
Five steps to writing a composition paper
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Home game help homework Child abuse and its psychological effect
Child abuse and its psychological effect
In families where there is a high level of conflict and animosity between parents, children are at a greater risk of developing emotional, social and behavioural problems, as well as difficulties with concentration and educational achievement. Conflict in families after separation Parental separation often initially leads to an increase in parental conflict and anger, although for some families the level of conflict reduces when parents do not see each other regularly. The level of conflict between parents usually reduces significantly in the two to three years after separation, although it remains high in approximately ten per cent of families. Research has found that following separation and divorce, children are twice as likely to have emotional, social, behavioural and academic problems compared to children from families that are still together.
Religious abuse or cult abuse The child is forced to accept the narrow, exclusive religious views of the parent or guardian to the exclusion of any other belief or possibility of any belief Any behaviour by the child not in line with the parents' rigid religious zeal is met with punishment and abuse The child is starved of development in interpersonal skills and relationships in the name of religion The child is subjected to strange, unnatural and often perverse beliefs on sexual matters and sexual development in line with the religious belief The child is discouraged or prevented from associating with any person not sharing the religious belief of the parent or guardian 6.
Emotional abuse, including refusal or unwillingness or inability to express love deliberate withholding of love conditional love eg "I don't love you when you behave like that" loving one child to the exclusion of all others cocooning and smothering, denying the child the opportunity to develop as a separate individual being forced into any conflict between parents being used as a pawn by warring parents being forced into a caring or caretaker role at an inappropriate age witnessing alcohol or substance abuse, especially on a regular basis, perhaps being forced to participate witnessing violence between parents or adults 7.
Psychological abuse, including constant criticism of a trivial and unjustified nature unjustified blame, often for things which have no connection with the child scapegoating refusal to value refusal to acknowledge the child and their achievements refusal to praise unclear, Child abuse and its psychological effect and inconsistent boundaries, sometimes no boundaries, at other times very tight boundaries refusal to make eye contact with the child over a long period refusal of parents to agree with or support each other when dealing with children unpredictable behaviour on the part of the parents Violent adults tend to be those whose childhood was characterised by experiencing the above behaviours on a regular basis, combined with lack of affection and lack of expressed love.
The three influencers of stress, namely control, prediction and expectation are pivotal see section on stress response on the health page. Where a child is brought up under these constant conditions, those areas of the brain which deal with interpersonal, behavioural and social skills simply fail to develop normally.
Effects of child abuse and neglect for adult survivors
In many cases of violent offenders eg serial killerstheir brain's frontal lobes - which modify and mitigate violent urges - are measurably smaller than in normal people. See the work of Dorothy Otnow Lewis and Jonathan Pincus for further insight into violent adult behaviour and its origins in childhood.
A child who is subjected to regular abuse, even if entirely non-physical, needs an outlet for their consequent aggression; frequently they will act out their violent impulses on another child at school bullyingor sibling, or family pet. Being violent towards others because they are violent towards you combined with the fact that you are unable to deal with other people's violence is called displacement aggression.
Violence towards animals eg torturing the cat or killing the dog is now recognised as a common early warning sign of forthcoming violence in adulthood. We're all guilty of some of these things especially the emotional and psychological abuse some of the time, either unwittingly or when we are stressed.
However, children are resilient and if you avoid physically punitive responses eg use restraint and the promise of a bonus or reward for good behaviour rather than punishment for bad behavioureducate them in how to show dignity and respect, teach them the skills of assertiveness which include psychological self-defencetalk to them and assure them of your love regularly, they're likely to grow up to be normal, well-adjusted and intelligent people - who will then pass on these benefits to their children.
For ideas on better parenting see and follow the links on the pages http: For dealing with verbal abuse I recommend The verbally abusive relationship: See their web site at http: Gratification The aggressive anxious adult learns that bullying results in relief from anxiety, which produces that nice warm feeling called satisfaction.
Gratification is the indulgence in the feeling of satisfaction resulting from relief from anxiety brought about by bullying. Bullying is therefore emotional and psychological displacement aggression.
Gratification is a behaviour loop in which the adult is trapped, and is the common denominator behind most forms of violence, especially sexual abuse and sexual violence. Corporal punishment and sexual assault "No one shall be subjected to torture or to cruel, inhuman or degrading treatment or punishment.
Only recently mid was corporal punishment in schools finally outlawed by the UK Parliament. Incidentally, this is a century after Parliament decreed it illegal to beat animals.H&P is an expanding Partnership based at King's College London and the University of Cambridge, and additionally supported by the University of Bristol, the University of Edinburgh, the University of Leeds, the Open University, and the University of Sheffield.
Statutes of Limitations (SOL) is the time in which a lawsuit is initiated by an injured person or victim. In most cases, unless there is a special circumstance, the SOL begins to run from the date of the occurrence that caused the injury.
Child Abuse And Abandonment – Effects On Human Resource Development In Nigeria
Published: Mon, 5 Dec Child Abuse and Neglect. Introduction. In today's society, especially іn U.K, we fail to address а numbеr of issues that need to be solved. Causes and effects of child abuse, sexual abuse, domestic abuse, emotional abuse and verbal abuse.
Childhood Psychological Abuse Has Long-Lasting Impact. The study confirms that childhood psychological abuse has lasting, significant damage, equal to or exceeding the long-term consequences.
Child abuse has been an emerging issue which created a huge controversy of how it affects children. Child abuse is in many forms and not just physical, but it is also psychological, emotional, and sexual.
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Attachment and Trauma Specialists - Child Abuse & Neglect


Add your review for Wong's Fu Wah.
Our family has eaten at this restaurant many times. The dishes we have tried are varied and all of them are freshly prepared and very tasty. The soups are excellent. What I found interesting is that the meal comes with a dinner roll. I found this odd....even americanized.......However, when I saw........ and ate the dinner roll, I didn't care what it was.......because it was huge!!! and delicious!!! The almond cookies are addicting too. Sometimes, I get them to go and have them with vanilla ice cream later. They didn't quite hit the nail on the head as far as the ambiance is concerned and the bathroom needs to be updated, but the place is clean and the food great!! Happy Dining!!
The food was of very good quality and there was a lot of it. The almond chicken was excellent. Good egg rolls and egg drop soup. I would definitely recommend this place.
I paid $15.00 for chicken lo mein, side of rice and crab rangoons but after grabbing the take out bag it felt like $25.00 worth. The food was tasty, the lo mein noodles are the very small type, but the crab rangoons needed more crab. Overall the food was good and they give you more than you could eat in one sitting. You definintely get your money worth.
Best General's chicken around. It's not breaded like at most Chinese restaurants. No lunch specials on Sundays.
Can't go wrong with the sweet and sour chicken!


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Home / TV /
'Grey's Anatomy' Star Giacomo Giannotti Posts Some Advice On His First Wedding Anniversary: 'Marry Your Best Friend'
Melissa Mitas
Fans of Grey's Anatomy know actor Giacomo Giannotti as the steamy Dr. Andrew DeLuca, ex-for-now-love interest of Dr. Meredith Grey (played by Ellen Pompeo). Recently hitting a personal milestone, the star of the medical drama took to Instagram to celebrate his one-year wedding anniversary and offer some words of wisdom to his followers.
Giacomo Giannotti of 'Grey's Anatomy' | Kelsey McNeal/ABC via Getty Images
'Grey's' Anatomy star pops the question
The Grey's Anatomy actor proposed to Nichole Gustafson, a makeup artist, on Thanksgiving weekend in 2017. "She said yes," Giannotti captioned a photo of the two kissing on Instagram. "I am truly one lucky guy, and I wouldn't rather be walking down this crazy road of life with anyone else. I love you. Thank you."
Gustafson posted her own celebratory message to let her followers know the ABC star had popped the question. "Yesterday my best friend asked me to marry him in the most romantic way, a day reliving our love," she wrote. "We are thrilled. I wouldn't want to do this life with anyone else. I love you baby and can't wait to be your wife 💍 This man has showed me what true love is. What a dream come true, pinch me."
The two wed in Rome, Italy at Villa Pocci on April 28, 2019, according to People.
She said yes… I am truly one lucky guy, and I wouldn't rather be walking down this crazy road of life with anyone else. I love you. Thank you. ❤ Mi ha detto di sì… Sono veramente fortunato. E non vorrei caminare giù la strada della vita con nessun altro che te. Ti amo. Grazie. ❤
A post shared by Giacomo Gianniotti (@giacomo_gianniotti) on Nov 26, 2017 at 9:58am PST
Giacomo Giannotti celebrates one year of marriage
The couple marked their first anniversary on Tuesday, with Giannotti sharing the milestone on social media.
"Our marriage has had its first trip around the sun! Can't believe it's already been a year. Happy Anniversary amore mio!" the Italian-Canadian actor posted on Instagram. "Still lovin, laughin and dancing in kitchens. Best decision I ever made."
The Grey's star gave a shout out to loved ones who attended their nuptials and showered the couple with mementos from the occasion.
"Sending love to all my friends family and loved ones who were there last year and have been flooding me with photos and memories from a year ago, what a time, what a party, what a time to be alive," he wrote. "Take me back."
Our marriage has had it's first trip around the sun! Can't believe it's already been a year. Happy Anniversary amore mio! Still lovin, laughin and dancing in kitchens. Best decision I ever made. Sending love to all my friends family and loved ones who were there last year and have been flooding me with photos and memories from a year ago, what a time, what a party, what a time to be alive. Take me back. Advice to all, marry your best friend. @nicki_makeup auguri amore ❤ : @linasdambrauskas
A post shared by Giacomo Gianniotti (@giacomo_gianniotti) on Apr 28, 2020 at 7:54am PDT
The happy groom added a tip to his followers considering a walk down the aisle. "Advice to all, marry your best friend," he recommended.
The makeup and hair stylist also posted a loving tribute to her husband. "❤my sweet love ❤ forever 4.28.2019. Happy 1st wedding anniversary @giacomo_gianniotti everyday with you just get's sweeter," Giannotti's wife wrote. "You are my everything and beyond."
ABC star didn't picture ever tying the knot
Giannotti told Entertainment Tonight that he hadn't envisioned himself getting hitched. "It's not something I necessarily dreamed of doing," he said in 2018. "I wouldn't consider myself a totally traditional person in the past. It was a newer concept that came to us, but when it came around, it felt so right and it fit. I was pretty blown away by how much it changes things, and positively. … It's beautiful."
The actor also revealed that having found someone he is so in tune with made their relationship a true bond.
❤my sweet love ❤ forever 4.28.2019 Happy 1st wedding anniversary @giacomo_gianniotti everyday with you just get's sweeter. You are my everything and beyond. Ti amo per sempre 4.28.2019 @morinafoto
A post shared by Nichole Gianniotti (@nicki_makeup) on Apr 28, 2020 at 9:19am PDT
"I think it's just recognizing a similar soul — a soul that feels like yours," Giannotti said in his interview with Entertainment Tonight. "[It's just] easy. When things are easy and don't have to be complicated, and you feel like you can both chase your own goals, but still be running together, that's a really exciting thing for me."


Description: The organisation of a kick-off meeting for the EUSBSR 14.3 Project in Hamburg and Stockholm.
Purpose: The purpose of the Kick-Off Meeting was to allow all of the partners to meet with one another prior to commencing Task activities. The secondary purpose was for the Lead Partner to provide guidance and clarification regarding project administration, reporting and communication.
Evaluation of the deliverable: The meetings were extremely productive and provided a good foundation from which to commence project and Task D activities. The kick-off meetings also helped to facilitate and promote good team working by the task members.
Value-added: None. However, this deliverable was of key importance for developing a functioning partnership and collaborative working for successful delivery of other deliverables.
Description: The organisation of a Kick-Off Meeting for Task D in Tallinn, Estonia and the production of a State of the Art Study on Flooding and Flood Prevention in the BSR.
Purpose: The purpose of the Kick-Off Meeting for Task D was to allow all of the partners to meet with one another and to begin discussions about flooding issues and to discuss and agree a final road map for Task D and the State of the Art Study. Another key purpose of the workshop was for Task D partners to develop a data collection questionnaire for the State of the Art Study. The primary purpose of the State of the Art Study was to identify, collect and summarise examples of good practice in flood prevention within the BSR. The secondary purpose of the State of the Art Study was to publicise and promote the key conclusions and recommendations of Task D.
Evaluation of the deliverable: The Kick-Off meeting was extremely productive and provided a good foundation from which to commence Task D activities. It also helped to facilitate and promote good team working by the task members. The Study is more comprehensive than initially anticipated. It includes a significant amount of information and explores numerous issues related to flooding and flood prevention.
Value-added: Yes. The document includes detailed information gathered from 6 BSR countries, but refers to literature from a wider number of EU Member States which further enhances its European added-value.
Dissemination: Publicly available via the CBSS website. Where possible, Task D partners will also upload the final copy of the State of the Art Study onto their organisations' websites. The CBSS are also printing paper copies of the Task D State of the Art Study.
Description: The organisation of Workshops 1 and 2 in Riga, Latvia on 21st and 22nd November 2012.
Purpose: To provide a forum to present, discuss and debate examples of good practice related to the topics of "Land use and legal aspects of flood prevention" and "Methodologies for dealing with Ice-Jams".
Evaluation of the deliverable: The workshops were extremely productive and provided a good forum for partners and external experts to discuss issues of importance within BSR countries.
Value-added: Yes. Both workshops were attended by representatives from numerous countries and organisations with a professional interest in flooding and flood prevention. The technical reports produced for the project provide excellent European added-value as they provide information to flood practitioners across the EU about the good practice examples that were presented and discussed.
Dissemination: The technical reports will be uploaded onto the CBSS website and, where possible, the websites of the Task D partners.
Description: The organisation of Workshops 3 and 4 in Warsaw, Poland on 9th and 10th April 2013.
Purpose: To provide a forum to present, discuss and debate examples of good practice related to the topic of "Use of Simulation in Flood Prevention" (WK3) and to provide a forum for partners to discuss, debate and agree the final conclusions and recommendations for Task D (WK4).
Evaluation of the deliverable: The workshops were extremely productive and provided a good forum for partners and external experts to discuss issues of importance within BSR countries. The partners successfully agreed a number of key conclusions and recommendations for Task D during Workshop 4. These conclusions and recommendations are publicly presented within the final chapter of the State of the Art Study.


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August 15, 2011 – Windjammer Capital Investors, a national private equity firm with offices in Newport Beach, CA and Waltham, MA, has acquired the operations of JWC Environmental (JWC) from Joseph W. (Woodie) Chambers Jr., a leading figure in the wastewater industry for nearly 40 years and an inventor of the Muffin Monster®. Terms of the transaction were not disclosed.
Headquartered in Costa Mesa, California, with operations in California, Georgia, the UK and China, JWC is one of the most recognized brands in the wastewater treatment equipment industry. JWC manufactures and services over 200 highly engineered variations of grinders, screens and processing systems, including the legendary Muffin Monster sewage grinder. Over 25,000 Muffin Monsters are installed globally to grind up the solid debris that ends up in wastewater pump stations, pipelines and sludge lines. The dual-shafted grinder protects pumps and downstream systems from clogging and potential damage.
"The acquisition by Windjammer is the next logical step in our company's history as we continue to invest in our products, capabilities and people in support of our growing base of customers," said Ronald A. Duecker, President and 30-year veteran with the Company. "Windjammer will provide JWC with access to capital and operating resources that will position us for growth through accelerated new product development, market expansion and other strategic initiatives. It's a win-win for both the JWC family and the wastewater treatment community," said Mr. Duecker.
In addition to its core Muffin Monster and Channel Monster® equipment, JWC produces a line of high-tech, high-flow wastewater fine and coarse screens under the Monster Separation Systems® trade name. These systems feature stainless steel or UHMW perforated plates and more traditional bars. When combined with the patented Screenings Washer Monster® they offer the most effective means to capture, remove and clean wastewater debris.
Since its founding in 1973, JWC has remained on the cutting edge of wastewater treatment technology. The firm developed a score of patented technologies, grew the product line into 17 different Monster solutions and has won the prestigious Water Environment Federation Innovative Technology Award four times – more than any other wastewater equipment manufacturer. In recent years JWC has been awarded patents for the breakthrough Screenings Washer Monster and the highly automated Monster Blind Diagnostic System™.
At this year's WEFTEC exhibition in Los Angeles JWC will roll out four new product innovations in both its grinding and screening product families. This follows the successful launch of four new products introduced during 2010's WEFTEC, including: new efficient Sludge Monster® grinder; new Honey Monster® SRS-XE with debit card option; new more powerful Screenings Washer Monster; and the new pre-fabricated Muffin Monster Manhole.
JWC sells and distributes its products through a global network of independent representatives and distributors. In addition, JWC provides extensive sales and service support through its regional and international manufacturing and service facilities. For more information, contact: jwce@jwce.com.
Windjammer Capital Investors, with offices in Newport Beach, California and Waltham, Massachusetts, is a national private investment firm that makes control and non-control investments in leading middle market companies in partnership with management. Founded in 1990, Windjammer manages institutional funds totaling over $1.2 billion of capital and is currently investing out of its latest fund of $575 million. In its history, Windjammer has closed on portfolio company investments with an aggregate value exceeding $7 billion. To learn more, visit http://www.windjammercapital.com.


The haze area expand wider, and moving north ward.
Number of hot spot detected at Sumatra has doubled to more than 400 spots. It could cause serious dense haze in next few days.
One casualty directly caused by haze has been reported in Malaysia. The victim has the history of asthma.


As the long summer of Labour's leadership campaign begins, all candidates must answer one question: how do you beat a Miliband? David started well, especially given his donation of at least a dozen supportive MPs to help Diane Abbott qualify, likely a clever ploy to split his rivals on the left. The only blot on Ed's campaign is his manager, Peter Hain—who had to resign from the cabinet for failing to declare donations last time he managed a campaign (his own) for Labour's deputy leadership. The brothers remain overwhelming favourites—and if any of the other three are to stand a chance they first must decide which Miliband they plan to dislodge. Here, the logic becomes convoluted. Ed Balls wants to be the left's standard-bearer against the Blairite David. But to get there he must gather enough second preference votes to see his former colleague Ed Miliband defeated in previous rounds of voting.
The only bright spot for whoever wins could be financial. The party is in effect bankrupt, but with the Lib Dems in bed with the Tories, Labour pockets virtually the entire pot of "Short money" for cash-strapped opposition parties. Not enough to fuel a Milibandwagon, but it is a start.
Which think tank rules the roost in the Lib-Con era? Things looked promising for liberal-friendly Demos—named "one to watch" in last year's Prospect think tank of the year awards—until its director Richard Reeves jumped ship post-election to work for Nick Clegg. He will be joined in government by one-time Centre for Social Justice boss Philippa Stroud, who left her post to advise Iain Duncan Smith. Cameroon admiration for the Sainsbury-funded Institute for Government will likely continue, despite news that its head, ex-mandarin Michael Bichard, is also to leave. Meanwhile the sole Lib-Dem tank, CentreForum, seems to be cashing in on the "liberal moment"—with a new chief executive, and promises of more boffins to be hired soon. Finally, there are changes on the Labour side, as ex-minister Kitty Ussher joins Demos, while both directors at the Institute for Public Policy Research have announced their departure. One of the duo, Carey Oppenheim, is to put her stint shepherding argumentative wonks to good use—she is retraining as a teacher.
The Dominique and Sarko show—again?
Who'd be Nicolas Sarkozy? Languishing in the polls, lambasted at home and increasingly mistrusted abroad by his one-time ally Angela Merkel, you'd think things could scarcely get worse. Step forward Dominique de Villepin, who has formed a new party to take on Sarko for the presidency. The silver-maned former foreign minister made his name in 2003 with an impassioned anti-Iraq war UN speech and, with several books of poetry and a multi-volume biography of Napoleon to his name, he is every inch the European intellectual. When Sarko leapfrogged De Villepin to become president in 2007 it looked like the end of the road. Now, Dominique is back. Few rate his chances of victory in 2012, but he could siphon off enough votes from his rival (a man he likens variously to a dwarf, a piglet or a midget) to let the likely Socialist candidate, IMF chief Dominique Strauss-Kahn, sneak through. Revenge, they say, is a dish best served froid.
The break-up of the state of Belgium seems ever more likely following the victory in June's elections of the moderate separatist New Flemish Alliance (NFA). (See "Brussels diary," p25.) The election campaign featured an increasingly comic series of disputes between the poorer francophone south and the wealthier Dutch north. Political debates ignored Belgium's record levels of debt, but saw plenty of angry words about the relative number of speed cameras in each region. (The responsible Walloons have hundreds, the Flemish hardly any.) Matters reached a low ebb in January when the NFA's leader Bart De Wever took part in a racy photoshoot with Miss Belgium. De Wever held a pair of scissors to the word "Belgium" on the beauty queen's sash, while both stood on a Belgian flag. Calls for both to resign quickly followed.
While the division of the country into two nations remains the most likely breakup scenario, a carve-up among its neighbours is also possible. Polls suggest that the French would back adopting their fellow francophones, while Belgian's southeast province—called, confusingly enough, Luxembourg—could join with its next-door namesake to form a newly expanded "Grand-Duchy." With Holland adopting the north and an independent Brussels, Belgium would simply drop off the map.
Whose head should really have rolled at BP?
As Prospect went to press, writes Derek Brower, one question was being asked noisily on both sides of the Atlantic: why hasn't BP boss Tony Hayward lost his job? His company is implicated in a disaster that killed 11 men and has caused an ecological crisis. BP's containment efforts have been largely unsuccessful, while analysts say its financial liabilities—which could run beyond $50bn—may see the company bankrupt. So, ultimately, Hayward has to go, along with a host of top managers. But—and here is the rub—for the shareholders' sakes they must hang on for as long as possible.
Going early would leave new management facing a Washington backlash that is still yet to reach its full force, while any promises of a clean sweep would be lost in the maelstrom. For BP, the smart scenario was Hayward staying in place for the congressional lynchings, which started in mid June. Is this fair? Not really: Hayward is hardly the reason BP has run into the mire. So expect the spotlight to fall increasingly on his predecessor Lord Browne, who faces accusations in the US that his cost-cutting and preference for management consultants over engineers helped lead BP into a number of precursor disasters, including a 2006 spill in Alaska. Hayward has been trying to deal with that legacy. And until the Macondo well blew in the Gulf in April, he'd been doing a fair job, too.
Afghan terrorists are rubbish. That, at least, is the conclusion of an article by Daniel Byman and Christine Fair in the summer issue of the Atlantic, studying half a decade of attempted mayhem by the Taliban. The conclusion? They may just be "the world's worst suicide bombers." Half of all bombers kill only themselves, a success rate that "hasn't improved at all in the five years they've been using suicide bombers, despite the experience of hundreds of attacks." All of which is heartening news. But perhaps one shouldn't judge the jihadis too harshly: the notion of a learning curve for suicide bombings is counter-intuitive, after all.
Forget football. Can we win the merchandise cup?
The 2010 World Cup will be remembered not just for its football, but for its atmosphere, writes Peter Watts—and more precisely for the vuvuzela, the noisy South African horn capable of creating a 120-decibel drone reminiscent of wasps trapped in a washing machine.
It's a marketing success that will not have gone unnoticed at the UK's Olympic Delivery Authority, tasked with identifying signature merchandise for the 2012 Games. Its inspiration to date has been limited to Canadian mittens: a cool 3m pairs of red gloves, branded with a maple leaf, were sold during the 2010 Winter Olympics, becoming something of a sensation following an appearance on Oprah. And while any profits from vuvuzelas go to the horn's manufacturers, the glove money was pocketed by the Canadian Olympic Committee. That's what the ODA is after: the right merchandise could help pay for a chunk of the £7bn athletic spectacle. So what can we expect? Olympic Uggs? A branded kazoo? Boris Johnson wigs? The products might be frivolous, but the search is earnest.


At the VBV Legends in Viareggio, Tuscany, FPT Industrial and FB Design unveiled, at a world premiere, the new "three point" hull concept - the hull has three support points on the surface -, ideated for water speed. The boat - designed by Fabio Buzzi - represents a vision for the future and it solidifies the collaboration of the two brands, a 35 year partnership distinguished by many successes.
Once again, after 15 world titles, several records and more than 100 victories both in Italian and International waters, FPT Industrial and FB Design manifested their mission: the innovation in speedboat racing. The new "three point" hull represents new progress toward future challenges: its aim is to achieve high performance, a very attainable target thanks to its carbon fiber structure and the power of the FPT Industrial engine.
The VBV Legends – taking place from the 7th to the 10th of July at the Viareggio Pier within NaviGusto event – is the international meeting for the main participants that took part in the historical Viareggio-Bastia-Viareggio race, the well-known off-shore boat event that was held between 1962 and 1992 and that now celebrates the numerous successes from the collaboration between FPT Industrial and FB Design. FPT Industrial won 32 titles, including 15 world championships in different classes and 17 International trophies: 7 in Europe, 4 in South America and 6 in Italy.
FPT Industrial marine engines and the hulls of FB Design also gained other records: two speed world records in the '80s and another one in 2012 during the New York-Bermuda obtained by "Col Moschin" who was equipped with two C90 650s. The same engines won a broaching during the Montecarlo-Venezia race in 2011 with the "Kerakoll FPT", while the "Red FPT" (also present at the VBV Legends), mounted with four N67 600 engines, won the Marathon World Cup in 2010, the most prestigious endurance race. This long lasting experience in this particular field has been the best "proving ground" for the know-how that FPT Industrial puts into the development of high performance, reliability and durability of marine engines which the brand offers to commercial and recreational markets.


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CELEBRATING JUNGLE SALVATION'S RELEASE! View in browser
Precious Gems Newsletter
Updates on releases and bargains for my peeps! Each reader is a precious gem. I'd love you to join my author's journey, however, you may unsubscribe at any time using the unsubscribe link below, or email me at talktome@majewell.com.
Hi Gems!
I'm totally stoked to announce Jungle Salvation's release TODAY!
Hint for my Gems--While the book is available at all major retailers ($4.99), EVERNIGHT PUBLISHING will have the title on sale ($3.74) AT THEIR SITE ONLY for about a week, so don't dawdle.
And remember, Jungle Rapture is available for only $0.99 at ALL MAJOR BOOKSELLERS for a limited time, so essentially you can get both reads for less than the price of one.
If you choose to buy either, truly, accept a heartfelt thank you. And if you leave me a thoughtful review, I'm yours forever!
M<3
New drawing guidelines increase your chances to win. Each click on a Precious Gems Newsletter promo earns you an entry into the drawing! Winners will be notified by email.
Congratulations to Barb, winner of the March 8th issue's drawing for a free E copy of Jungle Salvation.
Congratulations to Lauren, winner of the March 8th issue's drawing for a $10 Evernight Publishing gift card.
IN HONOR OF JUNGLE SALVATION'S RELEASE, WE WILL HAVE TWO DRAWINGS! 1-$10 EVERNIGHT GIFT CARD 2-$5 AMAZON GIFT CARD. Good luck!
March 15th Release!
Dragged back into the human world by well-meaning friends, jaguar shifter Matteo D'Cruz realizes he's been in cat form for over seventy years. With another transformation, he could lose his tenuous hold on his humanity. There's no salvation for a feral shifter, only execution. Damaged by grief and guilt, he's not sure he cares. However, when he discovers an unmated female shifter, he can't resist her scintillating allure or his instinct to protect her at all costs.
Carefree Dakota Gorman travels to Brazil to rescue her sister. Determined to expose the drug lords who have manipulated her sibling into a hurried wedding, she's certain the baffling hottie Matteo is one of them. After Dakota's sister turns into a giant jaguar before her eyes, she must confront a new reality, one including hidden family traits.
Matteo helps her trigger her first exhilarating metamorphosis into a jaguar, leaving no doubt about her genetics, but her joy is cut short. A blackmailer sends Matteo a video of her transformation, demanding DNA samples. The extortionist threatens to post the recording to the internet and expose the shifters to the world. Dredging up courage she didn't know she had, Dakota joins Matteo and the other jag shifters to save her family—and her new species—from scientific experimentation.
Available at all major booksellers for $4.99
$3.74 only at Evernight Publishing
EVERNIGHT PUBLISHING
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Asher Blossom only lives for one thing - to honor the dying wish of those he has loved and lost.
He will complete his studies at Cambridge and break free his siblings from the tradition of the Blossom family business. Especially after it held so many secrets, regrets and danger for his parents.
Returning home after nearly three years, he not only realizes how much his younger siblings have grown, but also how much they have grown apart. Despite his many long-distance conversations with his Uncle and siblings the household have many things they keep from him.
Determined to fix his broken family, and bury the guilt he feels for not being able to stop the fatal accident that claimed the life of Amanda, the love of his life , and his parents - he gathers up the family for a nice dinner and a talk. Leaving the house he unexpectedly returns to grab something he left behind only to discover intruders have broken in.
When he tries to stop them, things go horribly wrong and he is forced into a life he never knew existed. One that holds dark curses, time magic and artifacts that could destroy reality.
When he learns about who, what and why the evil has come their way, he is suddenly faced with a dream he wanted for so long.
Will he finally be the hero he wasn't on that fatal day? Can he go back in time and change it all , melting away the regrets that consume him everyday?
Or can he break the Blossom Blood curse and destroy the evil that wants to use him?
**A Second Chance, Small Town Romance**
I was mortified. I ran away because I couldn't face the embarrassment of what took place at the party. Now he's back in the picture and I don't think I can face him.
Will he remember who I am?
Sam Ellis was not your average Sutton Hill resident. The quaint, coastal town known for its sunshine, crystal clear water, and waspy, upper-class residents. No one was more unfitting than Sam.
Sam used to live a fast life: the exotic cars, big house, women that threw themselves at him but when asked to take over his father's estate all he wanted to do was be left alone.
A little rough around the edges, Jamie never had the best luck. After years of playing venues with her bandmates, she met Sam, entrepreneur and high-profile member of the Sutton Hill Country Club. After crossing paths, Jamie could not get Sam out of her head.
Would Jamie be enough for the hot billionaire who already had everything?
*Please also note this is a rerelease and rebranding on an improved newer edition. This book is an extended version with more content, new cover, and a preview of Book #2 in the Serendipity series: Twelve Weeks
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Escaping from a venomous gargoyle Searching for a hidden diary And running from a vengeful vampire hunter wasn't how Laura Dantonville expected to end her family curse.
Alec and Laura's story comes to an electrifying conclusion in this final installment of The Dantonville Legacy Series.
What do you do when the price of ending a curse means losing the one you love?
As Laura and Alec await the birth of their child, the end of the curse seems in sight.
To fulfill the prophecy, they must travel to Drunvela, in Scotland, the place where everything began and where it must end.
But two deadly foes stand in their way.
Each determined to exact their revenge and destroy every last descendant of the House of Dantonville.
With the ending of the curse so near, can Alec and Laura survive this last … and deadliest threat?
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YA Paranormal Romance/ Fantasy
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Teenage girls don't believe in fairy tales, and sixteen-year-old Elena Watkins was no different.
Now Elena's in a new world, and a new school. The cutest guy around may be an evil dragon, a Prince wants Elena's heart, and a long-dead sorcerer may be waking up to kill her. Oh. And the only way Elena's going to graduate is on the back of a dragon of her own.
Teenage girls don't believe in fairy tales. Now it's time for Elena to believe – in herself.
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