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Home » Human Relationships » Conflicts
Putting People Down: A Subtle Form of Aggression
Putting people down is a form of symbolic elimination. It's an unpleasant practice that sows the seeds of great personal and social unrest.
Four Subtle Forms of Psychological Abuse
Hostility in a Relationship is the Prelude to the End
Are You Caught in a One-Sided Relationship?
Putting people down is an antisocial practice that consists of looking down on others with indifference to their feelings and value. Someone speaks, and it's as if they were saying nothing. They ask for something and it's as if it's not important. In other words, it's as if the other person doesn't exist. That's what putting people down is all about.
We have to say that putting people down is a form of moral or psychological violence. It's an expression of cruelty that some people or groups believe they have a right to exhibit. It's very common for victims of this practice to be in fragile conditions or considered inferior.
"The opposite of love isn't hate, it's indifference. The opposite of art isn't ugliness, it's indifference. Heresy isn't the opposite of faith, it's indifference. And the opposite of life isn't death, it's indifference."
-Elie Wiesel-
Putting people down is synonymous with symbolically eliminating them; it's a type of social murder. In many cases in history, this symbolic murder precedes physical murder. This type of premise becomes the justification for specific violence, exercised against specific persons or groups.
Putting people down
Symbolic exclusion or elimination doesn't always have the same degree nor the same intensity. You can just put people's ideas or feelings down or you can put them down completely. This can occur towards certain social groups as well, as is the case with the different forms of McCarthyism, xenophobia, or discrimination.
For example, you put others down when you say things such as "What you said is completely wrong" or "Your thoughts are incorrect". The question is: who has the authority to radically put down what someone else thinks?
At most, a person could give some arguments or evidence to defend their reasoning. Although it's okay to put forward different ideas, you shouldn't put down the other person's.
The same is true regarding other people's feelings. How often have you said things such as "You can't possibly feel that", "How can you be scared of that?", or "You're crazy for getting upset over that"?
All these statements deny what the other person is feeling. Who has the right to tell people what they should or shouldn't be feeling or thinking? The answer is clear. No one.
The social nobody
This type of practice is also carried out socially or collectively. It doesn't necessarily involve "bullying". Indifference is enough to make another person feel that they aren't valuable. This is what many governments and individuals do with the most vulnerable population groups, such as the poor. They ask them to vote and then implement policies that don't take them into account at all.
In addition, this happens in daily city life. Cities are designed to make car rides smoother and easier but not to protect the life of pedestrians. Many car owners believe they own the roads and that they can do anything they like. It's a sad reality that more people in the world die from car accidents than from any known disease.
Bureaucracy is an expert at treating people like dirt. In fact, you can experience this if you have to carry out a certain task or hand in some paperwork. Government officials often play with your time as if it were a game.
They send you from here to there, sometimes demanding ridiculous requirements and putting obstacles in your way. Sometimes, this is due to sheer incompetence or lack of organization. However, on other occasions, it's just politics and underhand business.
Fighting indifference
Putting people down, or being indifferent to their needs, creates a seed of violence in its victims. That violence doesn't go away but builds up inside instead.
After a while, the victim ends up taking their anger out on the person who started it. On other occasions, the internal build-up affects and undermines their well-being and can even make them ill. Whatever the case, sooner or later, society will end up suffering in some way.
On an individual level, it's important for you to develop antibodies to fight against this disease. You must be aware that you're going to run into people who love putting others down at some point in your life. Thus, what you need to do is not take their bait and let them make you feel insecure or inferior.
At a social level, there's a call to promote inclusion. No matter how different we all are, everyone's entitled to their place in society. No one can force you to share or even accept their ideas, feelings, or conditions.
However, you do have an obligation to respect their right to be who they are. Your well-being (and theirs) depends on you having an open mind!
The Indifference of Passive-Aggressive People
Passive-aggressive may seem fragile and in need of help. However, the truth is that they have deliberate behaviors that they pretend to be accidental. Read more »
Huamán, M. Á. (2001). Contra la crítica del susto'y la tradición del ninguneo'. Alma Máter, (20).
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Singapore deploys one more aircraft to help search for missing plane
The RSAF's Fokker-50 Maritime Patrol Aircraft on Friday took off from Changi Airbase West and headed for the Strait of Malacca with six officers on board.
SINGAPORE: Singapore deployed one more aircraft on Friday to help with the search for the missing Malaysia Airlines plane.
The RSAF's Fokker-50 Maritime Patrol Aircraft took off from Changi Airbase West and headed for the Strait of Malacca with six officers on board.
Singapore has previously activated six types of military units, including helicopters, planes and vessels.
In a Facebook post on Friday, Prime Minister Lee Hsien Loong said it is disturbing that the plane is still missing after a week.
He said he wrote to Malaysian Prime Minister Najib Razak and Chinese Premier Li Keqiang on Friday to express solidarity and offer support.
Separately, Defence Minister Ng Eng Hen said: "Singapore is not giving up. As part of our international efforts, I can say that our servicemen from the SAF are actively looking for the missing plane, whether it's in the air, on the water or underwater.
"All our efforts now must be on behalf of families of passengers of the missing airplane."


March 2: Conversation with Abril Moreno, Organizer for Voces de la Frontera: Join us for a potluck dinner at 6:00 p.m. followed by a conversation with Abril Moreno, the Madison organizer of Voces de la Frontera, Wisconsin's leading immigrant rights organization. Abril will share what the Madison chapter has been doing, discuss Voces' efforts to fight for immigrant rights, and help our members get involved. The vegetarian potluck is at the home of Melanie Herzog and Norm Stockwell, 401 Elmside Blvd.
March 4: CSS Social Action Committee update: From 9:50-11:30 at 2120 Fordem Ave. Come join us for this update on the social action projects CSS is engaged in and our plans to continue our commitment to Voces de la Frontera.
**Shaarei Shamayim has agreed to welcome a refugee family resettling in Madison. We are in need of some volunteers to 1) join the committee, 2) sort through donations, and 3) help move furniture. If you are interested, please be in touch with Meg at meglamm@gmail.com.
**Looking for someone to coordinate the State Street meal that CSS does every other month. Laura and Aaron are moving this summer and they need to pass the baton to someone else to head this up. Let me know if you are interested in learning more about it.
Feb 22nd: Moms Demand Action Madison February Meeting: Come to the Pinney library branch at 6:30 to learn about taking action against gun violence. More details here.
Feb 27: Racial Disparities in the Criminal Justice System: Educational Series: Temple Beth El presents a 3-part education al series. Part 1 is from 6pm – 9pm. Viewing the documentary 13th, followed by a panel and group discussion. Attend 1, 2 or all three sessions. Click here for more information and to register. Temple Beth El is at 2702 Arbor Dr.
March 2: Core Action Café: At Centro Hispano from 9 am to noon. This is a creative, engaging process for collaborative reflection --- leading to action. For more information click here.
March 7: Crossroads of Inheritance and Discovery – Inspiring Interfaith Action: Mr. Patel is the author of Acts of Faith, the 2017-'18 Common Reading selection for Edgewood College. He is the founder of Interfaith Youth Core, an organization built on the idea that religion should be a bridge of cooperation rather than a barrier of division. He will give a talk at 7:00 pm in the Anderson Auditorium at Edgewood College. More details here.
Feb 22nd: Family Lobby Day: "No to the hate bill AB190/SB275, Yes to Driver Licenses. 10am in the Assembly Parlor on the 2nd floor. From Voces de la Frontera, "Join us to urge Wisconsin legislators to reject AB190/SB275 and instead support returning driver licenses to Wisconsin immigrants. AB190/SB275 is a hate bill that would allow local employees to investigate immigration status and mandate authorities turn immigrants over to ICE. The bill would separate Wisconsin families, increase discrimination and racial profiling, harm our economy, and make everyone less safe. Returning driver licenses to Wisconsin immigrants would ensure that all Wisconsinites have the right to do things like drive to work, pick up kids, and move safely without fear. Licenses would make our roads safer, improve our economy, and stop immigrant families from being targeted by deportation agents because of a lack of a driver license." More details here.
Now: Taking action on gun violence: The gun carnage continues and it is hard to see how this current Congress and President will do anything about it. There are organized groups that do a great job mobilizing the many people that want our gun laws to change. Indivisible has good talking points for calling legislators and Moms Demand Action has an active chapter in Madison.
If you are a twitter, follow some of the people at #ParklandStudentsSpeak to keep current. And support whatever efforts our high school students plan to try push back against the cynical notion that nothing can be done to stop this.
And while it seems unlikely that we move our Senator to change his mind about gun control – let him know how you feel. Here are some possible talking points.
Now: Protecting Dreamers: Indivisible updated their Immigrant Ally Toolkit to help us support Dreamers. DACA recipients will begin losing their protections at a rate of 1,200 a day beginning March 5, and Trump and his white supremacist cronies are holding Dreamers hostage to push a radical anti-immigrant agenda. The fight in Congress over Dream Act continues, and Indivisible lists ways that you can help locally. Click their toolkit for more information.
**In the who is the single worst person in the United States competition, it would be hard for me to vote against Paul Ryan. This man knows better and does not care. Read this to shore up your resolve to do whatever you can so he is not the Speaker of the House after the 2018 elections.
**Take a second to feel encouraged. Democrats flipped a Kentucky state legislature seat in a district that Trump won by 49 points in 2016. Linda Belcher won the special election in Kentucky's House District 49 by a 68-32 margin. Trump carried the district by a 72-23 margin in 2016, which also went 66-33 for Mitt Romney in 2012.
Feb 18: Networked News, Racial Divides: A Conversation with Sue Robinson.
From 9:50-11:30 at 2120 Fordem Ave. Sue Robison, UW professor and CSS member, talks about her new book, Networked News, Racial Divides: How Power & Privilege Shape Public Discourse in Progressive Communities. "Against conventional wisdom, pervasive black-white disparities pair with vitriolic public conversation in politically progressive communities throughout America, Networked News, Racial Divides examines obstacles to public dialogues about racial inequality and opportunities for better discourse in mid-sized, liberal cities -- especially in Madison, WI -- the major focus of the work. Media expert Sue Robinson will read excerpts from this book and explore how privilege shapes discourse and how identity politics can interfere with deliberation. Key to this talk will be a discussion with participants about ways in which we can move forward in building trust in our diverse communities." More details here.
Join us for a potluck dinner at 6:00 p.m. followed by a conversation with Abril Moreno, the Madison organizer of Voces de la Frontera, Wisconsin's leading immigrant rights organization. Abril will share what the Madison chapter has been doing, discuss Voces' efforts to fight for immigrant rights, and help our members get involved. The vegetarian potluck is at the home of Melanie Herzog and Norm Stockwell, 401 Elmside Blvd.
From 9:50-11:30 at 2120 Fordem Ave. Come join us for this update on the social action projects CSS is engaged in and our plans to continue our commitment to Voces de la Frontera.
Come to the Pinney library branch at 6:30 to learn about taking action against gun violence. More details here.
At Centro Hispano from 9 am to noon. This is a creative, engaging process for collaborative reflection --- leading to action. For more information click here.
Mr. Patel is the author of Acts of Faith, the 2017-'18 Common Reading selection for Edgewood College. He is the founder of Interfaith Youth Core, an organization built on the idea that religion should be a bridge of cooperation rather than a barrier of division. He will give a talk at 7:00 pm in the Anderson Auditorium at Edgewood College. More details here.
Voces de la Frontera is asking us to call Senator Tammy Baldwin at 202-224-5653 and urge her to support the clean Dream Act.
"The Senate is voting Thursday and Friday on legislation that could protect the hundreds of millions of immigrant youth left vulnerable to deportation by the President's cruel decision to end DACA.
But Trump isn't negotiating. He's trying to use the DACA crisis he created to drag the immigration system back to the Jim Crow era. We urge all Democratic and Republican Senators with a conscience to hold the line and vote against every amendment that isn't a clean Dream Act.
"My name is _____ and I live in _____, Wisconsin. I would like to urge Senator Baldwin to stand strong for the clean Dream Act with a path to citizenship for immigrant youth, and to reject any amendment that would build a racist wall, ban families from immigrating, or separate more immigrant families. She must hold the line and reject every bill except the clean Dream Act. Thank you."
Taking action on gun violence. The gun carnage continues and it is hard to see how this current Congress and President will do anything about it. There are organized groups that do a great job mobilizing the many people that want our gun laws to change. Indivisible has good talking points for calling legislators and Moms Demand Action has an active chapter in Madison.
Indivisible updated their Immigrant Ally Toolkit to help us support Dreamers. DACA recipients will begin losing their protections at a rate of 1,200 a day beginning March 5, and Trump and his white supremacist cronies are holding Dreamers hostage to push a radical anti-immigrant agenda. The fight in Congress over Dream Act continues, and Indivisible lists ways that you can help locally. Click their toolkit for more information.
--Feb 20th: Upcoming primary election. The League of Women Voters in Dane County has a useful informational sheet on what you need to vote. Please share this with people you know that might not be up to speed with the changes in Wisconsin's voting laws. The main election is for the Supreme Court, to see which 2 candidates will be on the ballot. The Milwaukee Journal Sentinel describes some of their views. Nothing could be clearer during this Trump presidency – it is important what judges sit on our courts.
"Drop in between 11:30 a.m. and 1:30 p.m. and call your legislators on your lunch break, with friends! Bring your lunch and we'll provide phone numbers and scripts to advocate for a CLEAN DREAM ACT. If you can give two hours, stay for an advocacy intensive through the Bend the Arc Jewish Action. We'll use their software to call other Jewish constituents to urge them to call their legislators. Please bring a laptop. Instructions and scripts will be provided. Located in the Social Hall at Temple Beth El." More detail here.
Hawthorne Library from 6:70-7:30. "Newcomers are always welcome at our People Power Dane County meetings! We'll be talking about our ongoing plans related to fair maps, voter registration and ID, and freedom cities. A detailed agenda will be distributed in advance of the meeting." Details here.
From 6-7:30 p.m. at the Urban League of Greater Madison. Come spend the night living, feeling and reliving the words of historical black poetry known as "Black Voices." From Love to Civil Rights, enjoy inspiring performed poetry of Langston Hughes, W.E.B. DuBois, Ralph Ellison, Gwendolyn Brooks, Maya Angelou and more! Details here.
The State Assembly Committee on Local Government isn't happy with local decisions that they don't like. This Committee wants to take some local decision-making away from Madison. AB 748 would eliminate Madison's ability to implement and enforce employment discrimination laws for the Madison community. Madison General Ordinance Sec. 39.03, the Equal Opportunities Ordinance, passed in 1963 (just before the Civil Rights Act of 1964) and has been in effect for almost 55 years. This legislation would eliminate the entire section of the ordinance which prohibits employers from discriminating in areas such as gender identity, credit history and criminal record. The public hearing will be held on Wednesday February 7th at 1:00 P.M. in the State Capitol, Room 400 Northeast. The Facebook event can be found here. And more details can be found here.
--Innovative projects are happening in Madison. Middle school students share their ideas to redesign Goodman Library's teen space.
--Can you never have too many books? The Literacy Network Book Sale is coming up.
--Support Madison Teens: The Goodman Community Center does great work with Madison teenagers. Working Class Catering is always looking for customers.
--The #ReleaseTheMemo fake scandal: Indivisible put together a bunch of information about what this memo is, what is could mean and some useful talking points about it.
--Mueller's investigation: Indivisible also put together a bunch of information on the quickly moving Russia investigation. They have updated their resources on the investigation and what they would like us all to do if Special Counsel Mueller or Deputy Attorney General Rosenstein are fired. They have teamed up with MoveOn.org and dozens of other allies to plan rapid response actions in case Trump takes significant actions to undermine the Trump-Russia investigation. Visit www.trumpisnotabovethelaw.org for more info.


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Saudi finance ministry sells 3.95 billion riyals of domestic sukuk
Saudi finance ministry sells 3.95 billion riyals of domestic sukuk /node/1310381/business-economy
(Shutterstock)
RIYADH: Saudi Arabia's finance ministry sold 3.95 billion riyals ($1.05 billion) of domestic sukuk in its monthly sale by re-opening an issue originally made last month, the ministry said.
It sold 3.35 billion riyals of five-year sukuk, 350 million riyals of seven-year and 250 million riyals of 10-year.
Last month, the ministry sold 5.0 billion riyals of domestic sukuk.
Topics: Sukuk Saudi Arabia economy Finance
UAE's Dana Gas agrees with creditors on $700 mln sukuk restructuring
Dubai-based Noor Bank plans roadshows for sukuk
Actis takes on management of two Abraaj funds /node/1526201/business-economy
US prosecutors have in recent months charged several executives of Abraaj with criminal charges, accusing them of taking part in a massive scheme to defraud investors
DUBAI:Actis said on Monday it had acquired the rights to manage two private equity funds previously managed by collapsed buyout firm Abraaj, in a deal aimed at strengthening its position in the Middle East and Africa.
Actis will take over the management rights to Abraaj Private Equity Fund IV and Abraaj Africa fund III, it said in a statement.
Abraaj, which filed for provisional liquidation in June 2018, was the largest buyout fund in the Middle East and North Africa until it collapsed last year in the aftermath of a row with investors over the use of money in a $1 billion health care fund.
The transaction includes investments in 14 portfolio companies across the two funds, Actis said.
"This Abraaj transaction further bolsters Actis' footprint in the growth markets and follows the addition and integration of Standard Chartered's Principal Finance Real Estate business in Asia in 2018," it said.
Abraaj, which filed for provisional liquidation in June 2018, was the largest buyout fund in the Middle East and North Africa.
Actis now has $12 billion under management and more than 250 people across 16 offices.
The Actis transaction comes after the finalization of two other Abraaj deals — the transfer of management of the $1 billion health care fund to US buyout fund TPG and the sale of Abraaj's Latin America fund to Colony Capital.
NBK Capital Partners, owned by Kuwait's biggest lender, walked away from advanced talks to buy a global credit fund previously managed by Abraaj, Reuters reported last month.
US prosecutors have in recent months charged several executives of Abraaj with criminal charges, accusing them of taking part in a massive scheme to defraud investors.
Topics: Abraj group
Saudi Bank customers warned of online fraudsters


Atmospheric, late 19th, French oil, impressionist, on board by Charles Pellegrin.
A rust red, gaff-rigged sloop is waiting for the tide. The sailors, in their black caps, concentrate on the rigging and look forward to setting sail as the apricot sun rises over the sea.
Artist; Charles Pellegrin, signed lower left.


Show your Virginia Tech Hokies pride every time you wear this Primary Logo Color Block T-shirt.
Womens_Fanatics_Branded_Maroon_Virginia_Tech_Hokies_Primary_Logo_Color_Block_3/4_Sleeve_Tri-Blend_T-Shirt http://images.fanatics.com/lf http://dmimages.ff.p10/chains/2949352.txt false We are unable to customize this item with the text you have entered. Please try a different entry again. Your current entry cannot be processed due to guidelines for past and present player names. Please create a new entry.


Are you still living in the 20th century, trying to climb the corporate ladder?
The Business of the 21st Century.
Who Should Read "The Business of the 21st Century"? And Why?
If you are an employee with dreams of climbing the corporate ladder or a self-employed small business owner, then you're still living in the 20th century, and you must read The Business of the 21st Century if you wish to make the much-necessary step forward (and upward).
However, if you're a big business owner or an investor, then you don't need Kiyosaki's book: you'll already living it.
is an American investor, entrepreneur and educator, most famous for his Rich Dad series.
The original book of the series, Rich Dad Poor Dad, spent six years on The New York Times bestseller list and was named "USA Today's No. 1 Money Book" for two years in a row.
This inspired Kiyosaki to add many other titles to the series which, combined, have sold almost 30 million copies in more than 50 languages and about 110 countries.
Kiyosaki has been featured on shows such as Oprah and Larry King Live and has co-authored a book with Donald Trump titled Why We Want You to Be Rich: Two Men—One Message.
He has co-written The Business of 21st Century with his wife, Kim Kiyosaki, and John Fleming, an architect, life-designer, and editor-in-chief of Direct Selling News.
If you know one thing about Robert Kiyosaki—OK, besides that he's the guy who wrote Rich Dad Poor Dad—you certainly know his Cashflow Quadrant.
However – and expectedly – there's much more to it!
Or to use the words of Kiyosaki, which quadrant do you live in, aka how do you earn most of your money?
You're here if you belong to the overwhelming majority of people.
Or, to be more exact, you're here if you're happy enough to not belong in the zero-quadrant, also known as being unemployed. Unfortunately, at least according to Robert Kiyosaki, 19% of young white men living in the US between the ages of 18 and 25 cannot find a job.
It's even worse for African Americans: a third of them face similar problems!
You, however, don't. You work hard in a moderately successful company, and you believe that, one day, your career will earn you just enough money to relax in the bliss of retirement.
Then again, maybe you've already migrated to the S quadrant.
Driven by your urge to earn more and to have more freedom, you decided to "fire your boss," found a start-up, and become your own boss instead.
Unfortunately, this has backfired: now you have even less free time (because taking a day off means earning no money at all) and you can't blame your boss for your problems (because that boss is you).
However, you feel that you're better off than in the E quadrant.
Of course, both the small business and the big business owners are self-employed.
However, the difference between the S quadrant and the B quadrant is straightforward: in the case of the latter, you're not working for your company, but your company works for you.
Finally, the I quadrant, in which it is not your business which works for you anymore, but your money.
You already understand its essence from Monopoly: "four green houses, one red hotel." All you need now is just a few books to master it.
Kiyosaki's The Business of the 21st Century is not for the I's and neither for the B's. It is about the E's and the S's.
And especially about those young people who haven't decided yet whether they'll live on the left or on the right side of Kiyosaki's quadrant (pun, of course, intended).
The corporate myth is over. If you've spent years climbing the corporate ladder, have you ever stopped to notice the view? What view, you ask? The rear end of the person in front of you. That's what you get to look forward to. If that's the way you want to view the rest of your life, then this book probably isn't for you. But if you are sick and tired of looking at someone else's behind, then read on.
Basically every modern book on retirement planning states this explicitly: if you're merely working somewhere, you're already doing it all wrong!
Because you're living in the past – more precisely sometime between the end of the 19th century and the 1980s.
You see, the "employment for life" myth didn't exist before the Industrial Revolution; before it occurred, in fact, there were many more S's than E's.
However, once the Industrial Revolution incited the demand for employees, most European governments took over the task of mass education.
The system adopted everywhere was the Prussian system – and, miraculously, most school systems in the world are modeled after it to this day.
And what they were promised in return?
Yet another Prussian idea, devised by then-Prussian president Otto von Bismarck in 1889.
We've already told you, but let us remind you yet again.
Back in the time of Bismarck, the average life expectancy was 45, and not many people lived to be old enough to start receiving their benefits.
Now, almost everybody lives past that age, and it's only a matter of time before pension funds go absolutely broke.
Still wanting to be an E or an S?
Because you're smart and because you've just realized that unless you're a B or an I, you'll never earn enough money to sit back and relax.
Well, it means that earning money actively will never get you anywhere; and even if it does, it will be at the price of your own freedom. Think of it as a race. You're not allowed to take a rest because then you'll be outrun.
However, if you're capable of finding a way to start earning money passively, then you can sit back and enjoy the view. Think of it as having someone else running in your stead.
Now, it's easy to say this; but somewhat tricky to put it into practice.
Because of the obvious Catch-22: in order to earn money, you need a big business; however, you need money to start a big business; the same goes for investing.
However, there's a great way to circumvent this obstacle.
Think of it this way: Jeff Bezos, Bill Gates, Elon Musk, Phil Knight – they all had friends when they were 18 or 20.
And they all wanted some support for their projects, whether financial or logistical.
If you had been one of the people to know them, even a single dollar might have made you a rich person today!
Network marketing is all about understanding the power of the power connectors.
When it comes to creating business success, it's not a simple matter of technical skills. Even more important are the life skills it takes to successfully negotiate the B quadrant. The key to long-term success in life is your education and skills, your life experiences, and most of all, your personal character.
The ESBI Quadrant is in the very essence of Kiyosaki's philosophy – which means it forms the basis of almost all of his books.
It states that, at least in terms of money, there exist only four categories of people: employees, small business owners, big business owners and investors.
The first two belong to the left side of the quadrant; the latter two to the right side.
Also: the first two belong to the past; the latter two to the future.
Choose wisely – because you can choose.
The point is not to get stuck in actively earning money – but to try and start earning. It's not about income, says Kiyosaki, but about assets which bring income on their own.
Spend as much time as you can developing these assets in your youth; you'll be more than thankful to yourself when you get older.
The essence of you becoming a B or an I (instead of living an unfulfilling life as an E or an S) is network marketing.
That is, finding people who'll share your dreams and ideas; people who want to be B's and I's as well; people who'll either buy your visions when the lack of money prevents you from turning them into reality or people in whose visions you can invest.
That's all the intelligence you need to become a successful person.
It is not real estate, gold, stocks, hard work, or money that makes you rich; it is what you know about real estate, gold, stocks, hard work, and money that makes you rich. Ultimately, it is your financial intelligence that makes you rich.
The Business of the 21st Century was published soon after the financial decline of 2008 and addresses Americans mainly through the prism of this crisis.
However, its message – if you want wealth, create it by taking charge of your income source – rings true even a decade later.
It does sound a bit simplifying here and there, but there are quite a few interesting takeaways. If you like Rich Dad Poor Dad, you'll like this one too.


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Home News Rent-to-Rent can make a serious dent!
Rent-to-Rent can make a serious dent!
Letting to an agent:
Rent to Rent means you rent your property to a "middle man", an agent who then re-rents (sub-lets) to an occupier, a tenant.
This has become a popular formula for some landlords. It removes the hassle of dealing with tenancies, achieves a 'guaranteed" rent for (usually) around three years, and the owner gets the property back in pristine condition, or so the theory goes.
On the other hand, the agent will be renting the property off the owner for a bit less than the market rent, making a profit on the deal for their trouble when they rent to a single or multiple tenants.
The practice has been heavily promoted by the "investment guru brigade" as a way for individuals to get into property without the need for a large investment. But unfortunately some of these would-be property gurus are amateurs with little experience at best, if not rogues at the worst, so things can go horribly wrong.
That's not the whole story of course; there are some genuine, professional and highly experienced agents offering this type of service, and some local authorities do so as well, but even so, owners need to be careful. There are some gaping chasms of risk that owners can fall into with this practice, so buyer beware.
First off, the legalities:
This is a rather complex and in some respects an indeterminate area of the law. There are in effect two tenancies here, one between the owner and the agent, and another between the agent and the tenant. Most likely the latter will be a standard AST (Assured Shorthold Tenancy), but the former is not, because the tenant is not an occupier, one of the main requirements of an AST.
The former would most likely be a contractual tenancy between owner and agent, but there are instances, dependent on the circumstances of the tenant's letting, and how the property's being used, where the former arrangement could be a commercial tenancy under the Landlord and Tenant Act 1954.
A commercial tenancy, if not set-up properly, can give the agent renewal rights, which could cause no end of problems for the owner when the term comes to an end. Likewise, even a straightforward arrangement with a contractual tenancy and an AST can present problems if at the end of the term the tenant remains in place. Here, under section 18 of the Housing Act 1988, the owner will inherit the tenancy, with all the problems that may entail.
Secondly, a trustworthy agent:
Can the agent be trusted to set-up a proper legal framework that fully protects the owner? And will they pay the guaranteed rent, even if there are void periods? Owners should be mindful that they should be dealing only with experienced agents who are members of one the recognised professional associations. Also, the agent should be using a knowledgeable solicitor to arrange the legalities.
If in doubt seek legal advice and get the agent checked out properly.
Thirdly, the regulatory risk:
There are now some swinging penalties for not following the rules and an innocent owner can get drawn into the fray. So if a rogue agent were a carry out internal alterations, increasing the number of lettable rooms to cram in more tenants, then things could get nasty. An illegal HMO (House in Multiple Occupation) is created which when not properly licensed carries fines of up to £30,000.
Evicting a rogue agent and the tenants he has rented to could take a lot of time and hassle, let alone all the expense involved.
Legal cases:
Given the number of these types of lettings over recent years, there are likely to be more examples of a case which came to court last month:
A rogue letting agent from Hertfordshire was fined £72,000 after it was said he had been "breaking almost every regulation in the book". Watford-based Muhammad Siddique was found guilty of 15 offences dating back to 2017.
Siddique had been operating three illegal HMOs without the knowledge of their owners, despite the owners thinking they were rented to single families. Inspectors found he was seriously breaching health and safety regulations and failed to provide gas and electrical safety certificates.
St Alban's Magistrates' Court heard that Siddique had been a franchisee of estate agency chain, Open House, but his franchise agreement ran out in 2016, terminated when the company became aware of his failure to meet compliance procedures.
Rent-to-Rent
Previous articleLandlords urged to respond to eviction ban
Next articleBexley landlords fined for overcrowding
Rent-to-rent tenants face 'scandalous' Universal Credit clawback, it is reported
London mayor launches initiative to tackle illegal evictions, rental scams and sub-tenancies


A Thermal Shirt is a Must Have!
It can be hard to feel stylish during the winter when you're bundled up in layer after layer of T shirts, sweaters, jackets, and more. But staying warm and looking great doesn't have to be such a challenge. If you're looking for a way to stay comfortable without looking like a marshmallow, a thermal shirt is an absolute must.
Thermal shirts work great with winter women's apparel thanks to their unobtrusive design. Though they are long-sleeved, the cotton materials keep these shirts relatively thin. This makes them easy to wear as an additional layer, without making your outfit look too bulky.
However, a thermal shirt doesn't have to be hidden by jackets and other extra layers. A simple yet stylish design ensures that you'll still look good even when you aren't using your thermal shirt for layering. Bold colors and attractive stitching make this a great option for lounging around the house — certainly a better winter casual wear option than T shirts!
No matter how you plan to use your thermal shirt, you can rest assured that it will help you stay warm and look great, even when the thermometer dips below freezing.


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Stolen tractor used to steal cash machine in Beaminster
ram raid
Saturday 18 August 2018, 3:36pm
The furniture shop has been left with significant structural damage. Credit: Giles Frampton
People in Beaminster had quite a shock early this morning when a stolen tractor was used to rip out a cash machine.
Several people called Dorset Police during 4am raid on the former HSBC on Fleet Street.
Thieves ran away from the scene before getting into a dark coloured Audi.
Police do not know yet if any money was taken.
Nobody is believed to be hurt but police say the furniture shop has been left with significant structural damage.
The road has been closed until a structural engineer can attend and advise on how to make the property safe.
I am also keen to hear from anyone who saw a Audi or similar looking car being driven in or around the area this morning or one that may have been abandoned. The offenders have caused significant structural damage to the property and the road has been closed to ensure the safety of members of the public until it can be made safe.
DS Simon Austin, Weymouth CID


text:
Shout! Factory Choriki Sentai Ohranger DVD Cover Released
Super Sentai MOVIE Ranger 2021 Advance Tickets and Exclusives Announced
This Week in Tokusatsu Merchandise 1/11/21 – 1/15/21
Mashin Sentai Kiramager: The Movie Preview Released
Kikai Sentai Zenkaiger DX Mecha and Figures Announced
Paula Gaetos
Shout! Factory releases the official cover art for the upcoming Chouriki Sentai Ohranger DVD set.
Similar to Shout! Factory TV's Ultraman 50th anniversary streaming event, Shout! Factory revealed the cover art for its upcoming Ohranger DVD release as a postcard available on the floor of San Diego Comic Con's Exhibit Hall.
Shout! Factory announced the latest in its Super Sentai collection during their Dairanger streaming marathon back in May. Ohranger is set to be released in November of this year in its original Japanese with English subtitles.
Ohranger is the 19th installment of the Super Sentai series and its footage was used for Power Rangers Zeo in 1996.
Source: Shout! Factory Press Relations
Related Topics:Ohranger, Shout! Factory, super sentai
Library paraprofessional, co-host of the Comfort Society podcast, and Founder and Editor-in-Chief of The Tokusatsu Network from 2014 to 2018.
More Details for Shout! Factory TV Ultraman 50th Anniversary Streaming Event
This Week in Toku Toys [07/24 – 07/30]


text:
Choi See-Joong (born 4 August 1937) is a South Korean politician who is the former chief of the Korea Communications Commission. He is notable for supporting controversial decisions in the South Korean telecommunication scene. He resigned on 27 January 2012, due to his involvement in bribery.

Criticism
Choi See-Joong has been criticized for defending the Lee Myung-bak government by supporting the SPO's active investigations against "anti-GNP" rumors in the social network services, akin to the Minerva incident.
He was criticized for supporting "a huge emphasis on advertisements for the Chojoongdong TV stations".
The SPO investigated Kim Hak-in (김학인), the chairman of the board Korea Broadcasting Art School, for giving bribes to Choi See-Joong in order to guarantee a director position of Educational Broadcasting System for Kim. There is a further allegation that the closest associate of Choi See-Joong, Jung Yong-uk (정용욱), has obtained a huge amount of bribes and moved to Canada.

See also
Lee Myung-bak

References

External links
  Naver Profile

1937 births
Lee Myung-bak Government
Living people
People from North Gyeongsang Province
South Korean journalists

redpajama_set_name: RedPajamaWikipedia


text:
Coll Roig és una collada situada a 2.728 m alt del límit dels termes comunals de Dorres i de Portè, tots dos de la comarca de l'Alta Cerdanya, a la Catalunya del Nord.

És a l'extrem nord del terme de Dorres i al nord-oest del d'Angostrina i Vilanova de les Escaldes, a la Serra de Coll Roig, al nord-est del Puig Occidental de Coll Roig, al sud-oest del Puig Oriental de Coll Roig i al nord-oest de l'Estany de Coll Roig.

Referències

Colls de Dorres
Colls de Portè


Be apart of our family practice!
Do you have any new patient offerings availble?
We provide new patients with the following offerings, Oral Cancer Screening, Jaw Joint Analysis, Digital Radiograph x-ray & Cosmetic Consultation. As a Special Introduction to our Dental Family This is available to you as a First Time Patient For only $89!


I was searching for a Property and found this listing (MLS® #19380475). Please send me more information regarding 17042 Fontana Rd 38, Bend, OR, 97707. Thank you!
I'd like to request a showing of 17042 Fontana Rd 38, Bend, OR, 97707 (MLS® #19380475). Thank you!


So Yesterday we was invited To Kidtropolis at the NEC in Birmingham to celebrate the Paw Patrol awards launch, to celebrate real life little heroes. Lexie was lucky to be about to do a meet Skye and get a super big fluffy hug.
For the second year the much-loved pups with their unique personalities and special characteristics are celebrating 'real-life' little heroes in the PAW Patrol Little Heroes Paw Awards 2019.
Do you know or have a little hero in your life who deserves to be recognised, ages from 3-10 years. and you would like to nominate them, you can enter the Awards by visiting www.PAWAwards.co.uk from 13th April, and sharing why this little one deserves to be one of the PAW Patrol Little Heroes of 2019. If you are nominating someone else's child, we ask that you seek permission of the child's parent first. Anyone can enter and there are 8 awards and will be chosen by a panel of judges, with some special prizes for the winners and runner ups.
Then here's the chance for you to help them shine with the help of their favourite pups. Parents of youngsters across the country will be very familiar with Chase, Rubble, Skye, and Marshall, just some of the heroic pups from Nick Jr's number one rated TV show PAW Patrol produced by Spin Master Entertainment.
Has your little one proven a responsible leader? Was there a time when they unexpectedly stepped up to the mark to lead, shown confidence, maturity or set a great example? Whether at school or at home, we'd love to hear!
Everyone needs a little help at times and often kids are not always first to offer - but if you have a special little assistant in your life then please share what makes them your helpful hero!


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The Death of Superman
The Man of Steel meets his ultimate match when Doomsday comes to Earth – hell bent on destroying everything and everyone in his path, including the Justice League – in the all-new, action-packed The Death of Superman, part of the popular series of DC Universe Movies. The film is produced by Warner Bros. Animation and DC Entertainment.
WITNESS THE DAY METROPOLIS STOOD STILL
Watch the trailer!
The Man of Steel meets his ultimate match when Doomsday comes to Earth – hell bent on destroying everything and everyone in his path, including the Justice League. The Death of Superman ultimately finds Superman in a fight to the finish when the Man of Steel becomes the only hero who can stand in the way of the monstrous creature Doomsday and his unstoppable rampage of destruction.
As the inaugural film in the DC Universe Movies series, Superman Doomsday told an abridged version of The Death Of Superman, DC Comics' landmark 1992-93 comic phenomenon. But with a runtime of 75 minutes, the film focused on a core, singular storyline. The new, animated The Death of Superman, the first of a two-part film experience that will conclude with Reign of the Supermen in early 2019, restores many of the moments and characters that fans hold dear to their hearts.
The all-star cast is led by Jerry O'Connell (Crossing Jordan, Stand By Me), Rebecca Romijn (X-Men, The Librarians) and Rainn Wilson (The Office) as the voices of Superman, Lois Lane and Lex Luthor, respectively. The potent trio is joined by the DC Universe Movies' returning voices of the Justice League: Jason O'Mara (The Man in High Castle, Terra Nova) as Batman, Rosario Dawson (Sin City, Rent, Daredevil) as Wonder Woman, Shemar Moore (S.W.A.T., Criminal Minds) as Cyborg, Nathan Fillion (Castle, ABC's upcoming The Rookie) as Green Lantern/Hal Jordan, and Christopher Gorham (Covert Affairs, Ugly Betty) as The Flash.
Producer Sam Liu (Gotham by Gaslight, Teen Titans: The Judas Contract) co-directs The Death of Superman with Jake Castorena (Justice League Action) from a script by New York Times best-selling author Peter J. Tomasi (Green Lantern: Emerald Knights). Executive Producers are Sam Register and James Tucker (Suicide Squad: Hell To Pay, Justice League Dark).
Click here for more details on Superman/Doomsday, the first DC Universe Movie title to adapt "The Death of Superman." For more Superman-centric animated movies, also check out Superman/Batman: Public Enemies, Superman/Batman: Apocalypse, All-Star Superman, Superman vs. The Elite and Superman Unbound!


A Brooklyn nursing home will have to pay nearly $19 million in damages to the family of a 76-year-old patient neglected so badly that he left the home with more than 20 bedsores. The award was handed down by a jury and is the first in the state to include punitive damages. The men entered the nursing home weighing 237 pounds and left to go to the hospital weighing a mere 148 pounds. The man wrongfully died from an infection caused by the bedsores. The panel awarded $3.75 million for the victim's pain and suffering and tacked on $15 million in punitive damages. This was based on the allegation that the nursing home had doctored records to try to cover up the nursing home neglect. It appears that the nursing home restrained the Alzheimer's-stricken victim to keep him from wandering off. They then left him unattended for long periods. Medical standards require that bedridden or restrained patients be moved every two hours to prevent such bedsores, and that the home only moved her every four hours. To learn more about the pressure ulcers, please click the link.


All reservations for party nights, private festive lunches & dinners will be treated as provisional and will be held for no more than 10 days pending receipt of written confirmation and a non-refundable deposit of £10.00 per person.
Full pre-payment is required 28 days prior to the event. Deposits are non-transferable.
For Christmas Day, Boxing Day, New Year's Eve, New Year's Day and Burns Night full prepayment is required at time of booking.
All alterations to a booking must be confirmed in writing.
Once final payment is made no refunds or credit vouchers will be given. We will however try to resell the places released but give no guarantee that this will be done. No refund will be considered on bookings cancelled less than 14 days before the event.
Any alteration to numbers must be advised at least 7 days prior to the event day.
In the event of any function having to be cancelled by the hotel, an alternate date or venue will be offered or a full refund given.
The hotel reserves the right to amalgamate Christmas events to ensure appropriate numbers. We also reserve the right to move the event to a different function suite should numbers dictate.
The hotel reserves the right to group small tables together on party nights, to create a more sociable atmosphere.
We reserve the right to cancel advertised entertainment due to circumstances beyond our control.
Any additional service or services must be paid for on the night. No credit facilities will be offered unless secured with a credit/debit card.
All times shown are subject to approval by the local licensing authority.
All details are correct at time of going to press but may be subject to alterations without prior notice. All prices quoted include VAT at the current rate.
All accommodation must be confirmed with either a credit card or full payment.
The management of the hotel reserves the right to refuse entry to the hotel. In addition the hotel reserves the right to charge the organiser, company or individual for any damages caused by unreasonable behaviour.
Restrictions apply to children at certain events.


Situated in the Somerset Levels, Glastonbury is best known for its Tor and Abbey, and the Glastonbury Festival, which is almost ten miles from town. Visitors come to see the colourful quirky little town at the heart of Somerset, shop for incense and crystals, and try some of the local vegan eateries. In contrast, neighbouring village of Street is home to famous Clarks village shopping centre with a large array of high street shops.
GlastonburyGlastonbury resident makes an emotional appeal to the council amid 5G rollout fearsThe council is being urged to "halt the installation of 5G"
GlastonburyGlastonbury artist creates an impressive life-size robot from roadside litter"I fulfill my creative interests to make good use out of something no longer wanted"


With recent research suggesting that the ecosystem is gradually collapsing, more and more folks worldwide are opting to live a greener lifestyle. From biking or walking to work to using environmentally friendly products, there are many ways you can reduce your carbon footprint to help the environment, including using eco-friendly building material.
Did you know that the majority of harmful greenhouse gas emissions come from buildings, not cars and trucks? This knowledge has resulted in recent efforts to develop green building materials and create better construction methods.
According to the Worldwatch Institute, a quarter of the globe's wood is used in building construction. This number only increases with the ever-growing worldwide population. The more people there are, the more homes and commercial businesses need to be built to accommodate living and working needs. This can put added pressure on increasingly scarce resources, such as different types of wood and even water.
Portland cement is the binding substance that is used in concrete and is responsible for up to 8% of the total greenhouse gases emitted by human activity. Using fly ash in lieu of Portland cement is a greener alternative, and is also more affordable. Fly ash is a residue created by coal-fired power plants. It also makes a higher quality product.
When selecting flooring or cabinetry for your new house, opt for bamboo. This durable and gorgeous building material is extremely environmentally friendly. While being five times stronger than concrete, bamboo is also lighter than steel. The plants can grow up to several feet per day, making it a sounder lumber alternative than other types of wood.
The drywall in most buildings is engineered from gypsum. This material demands high heating and mixing stages to produce the end result. In the U.S., 50 billion square feet of drywall is made every year, resulting in 200 million tons of carbon monoxide. A solution is to start using EcoRock in place of traditional gypsum to make drywall. This substance is created through a natural chemical reaction, which eliminates the need for the heating and mixing stages that can cause pollutants in the atmosphere.
When considering energy sources for your home, choose renewable energy. Solar panels on your roof can efficiently cool and heat your home throughout the year. They also drastically reduce energy bills, putting green in both your wallet and on the planet.
There are many methods to living a greener lifestyle and constructing a home that caters to the needs of the planet's fragile ecosystem. Use the aforementioned alternatives to safe both money and the earth.


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Promoting Migration Governance
Cooperation between trade unions & stakeholders in North Africa, West Africa & Europe
The development, implementation and monitoring of rights-based national migration policies and strategies require greater accountability and coordination of trade unions from countries of origin, transit and destination.
The regional project "Promoting Migration Governance"- PROMIG-FES (2017-2020) reflects the continuing support of the RSMMS by the Friedrich Ebert Foundation in Tunisia. It revolves around the idea of promoting the role of social partners, in particular of trade unions, in the joint governance of migration, rights-based mobility and social dialogue. The project follows a multi-stakeholder approach and a multidimensional perspective. PROMIG-FES fosters a more diverse discourse on labor migration through its pilot activities, alternative to the dominant security narrative.
PROMIG-FES (2017-2020) is a strategic partner of the Mediterranean Subsaharan Migration Trade Union Network - RSMMS.
The project's objectives:
Promoting the role of trade unions in the joint governance of migration, rights-based mobility and social dialogue
Trade unions develop national strategies and coordinate them at the regional level for a better integration and protection of migrant workers.
Trade unions in North Africa, West Africa and Europe set up a thematic platform for supra-regional coordination, with a view to intervening more effectively for a better protection of migrants.
Trade unions work together in North Africa, West Africa and Europe to adopt more progressive migration policies.
The project is funded by the German Federal Ministry for Economic Cooperation and Development (BMZ).
Project brochure (available in FR)
Mediterranean Subsaharan Migration Trade Union Network – RSMMS
Since its fourth GA meeting in February 2018, the RSMMS counts 24 trade union members, covering 14 countries in three regions. Algeria, Benin, Burkina Faso, Ivory Coast, Spain, France, Italy, Mali, Morocco, Mauritania, Niger, Portugal, Senegal and Tunisia (see updated list of the RSMMS members).
Created in 2014 (see the Casablanca Declaration), the RSMMS brings together unions that have chosen to raise as a part of their agenda the protection of the fundamental rights of migrants and their families as well as the protection of the rights of those workers who transit or settle in their country. Together, the RSMMS member unions unite with the aim to develop joint and coordinated approaches between trade unions in the sending and receiving countries to articulate trade union solidarity and to harmonize the actions of the member unions in the field.
Strategic vision of the RSMMS: Promoting trade unions' action for decent work for migrants
Three areas of intervention are prioritized by the RSMMS members:
The support of migrant workers;
Social dialogue as a vehicle for rights-based migration policies;
Trans-regional solidarity and a unified position of different trade union families in favor of equitable global governance.
Three transversal themes constitute the guiding thread in regards to three areas of intervention:
Promotion of international standards;
The coherence of local and regional initiatives and the exploitation of synergies;
Resource mobilization and dynamic partnerships in the delivery of technical assistance (see RSMMS 2018-2019 Strategic Note).
www.rsmms.int (upcoming)
22.08.2019 | Program Migration | Events
Interregional trade union solidarity and migration - Unions affirm their commitment
The Fifth General Assembly of the RSMMS was a major trade union event on migration issues. From 2nd to 4th July 2019, thirty organizations and more…
Mali: A Panel on Migrant Governance and Social Dialogue, Bamako Forum
In the 19th edition of Bamako Forum, this year the theme of migration dynamics between Europe and Africa was covered. This topic was tackled by a…
Tunisia: Consultative Workshop of the Migrant Population of Sousse
A meeting with members of the migrant community of the Sousse region took place on Sunday 17 February. The workshop brought together around thirty…
| Program Migration | Publications
Testimonies of migrant women workers from Senegal
This publication aims at presenting testimonies by those whose plight is widely discussed - but who rarely have the chance to speak for themselves:…
Etat des lieux de la convention de sécurité sociale entre le Maroc et l'ltalie
L'absence de convention bilatérale entre le Maroc et l'Italie a fait l'objet d'une attention particulière des membres du Réseau syndical RSMMS. Cette…
Rapport de formation des points focaux des syndicats membres du Réseau Syndical Migrations Méditerranéennes – Subsahariennes (RSMMS)
The workshop with representatives from RSMMS, taking place in Tunis the 6th - 8th of October, aimed to nourish a coordinated inter-regional approach,…
Sami Adouani
FES Tunisia
4, rue Bachar Ibn Bord
B.P 63
2078 La Marsa
Lina Zekri
Principal consultant / PROMIG-FES project
Leyla Chaari
Junior Programme Coordinator
Rami Walha
Finance and project assistant
Mustapha Msalem
PROMIG News
The project newsletter "PROMIG News".
Edition 1 | Edition 2


The GN Committee is pleased to share links to the websites and/or blogs of the following Grand National artists, past and present.
If you are a Grand National artist and would like to be listed, please contact us at grandnationalquiltshow@gmail.com.
All rights reserved. No part of this site may be copied or reproduced by any means without permission. All designs appearing on this site are copyrighted material owned by their respective creators and may not be reproduced without written permission.


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What You Need to Know About Ashland, California
There is so little information about Ashland, California. Not so many people provide information about this city, other than the websites that are established by their local government. Still, other websites are undergoing renovation or it could be that it would take time to put up a site with information that every visitor of Ashland will truly enjoy reading.
What you will find here is basic facts about the city itself.
Ashland, California
Formerly known as San Leandro South, this is a CDP or census-designate place in the Alameda Country in California. CDP refers to the population concentration as defined in the United States Census Bureau for purposes of statistics only. This has been used in every decennial census since the year 1980 as a means of counterparts in various incorporated places like the self-governing villages, towns and cities. This is for the purposes of correlating and gathering statistical data. As of 2010 census data, the population has reached 21,925 in this CDP city.
Ashland was developed back around 1940s.
Ashland is a community situated between the cities of Hayward and San Leandro. It is estimated to be bounded by the Hesperian Boulevard in the West, 150th Ave in the North, Hampton Road at the South and I-580 at the East. You will also see here the Cherry land district.
Ashland then got its name after the Oregon ash trees that were once proliferating in the area. Back in the 1890s, people were able to ride the electric street car to Hayward from Oakland, which passes through various farms and orchards in Ashland. In the 1930s, nurseries and greenhouses replaced majority of the farms in the area. The place even had its own automobile racetrack situated where you could find the Bayfair Mall today. After World War II, the nurseries that once replaced the farms were then given way for housing development for the booming population of the District.
Today, Ashland is one vibrant community that is cantered around the E. 14th Street retail district. The Ashland REACH Youth Centre is the most active hub in the entire district, wherein it serves the youth throughout the Alameda County. They also even host annual events in the community. Some of its upcoming events are soul music, food stands, public performances and many more.
The schools that you'll find in this place are the Hesperian Elementary and Hillside Elementary for the elementary education. Middle school is the Edendale Middle School, while High School is the San Lorenzo High School.
Dining, Shopping and more
Ashland may not be as ear ringing for most people, but at least if you live here or visit the place, you'll find a lot of restaurants to dine in. One of the very popular places to visit is the Luccas Italian Delicatessen, which has been voted as the best delicatessen for 17 years. For old fashioned ice cream, go to Knudsen's Ice Creamery, which is situated right in the Castro Valley neighbourhood.


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Advances in Immunotherapy: Using an Antibiotic to Remote-control CAR T cells
Posted on August 23, 2016 August 25, 2016 by Srivani Ravoori, PhD
A study published recently in the AACR's journal Cancer Immunology Research describes an important update to the CAR T-cell technology, in which researchers have devised a mechanism to turn the CAR T cells "on" or "off" using a remote-control switch in an effort to tackle the toxic side effects of this promising form of immunotherapy. The switch is the antibiotic doxycycline.
As described previously on this blog, CAR T-cell therapy is a type of investigational immunotherapy that is based on a technology called adoptive T-cell transfer. It involves removing T cells from a cancer patient's body, then modifying them so that when reintroduced into the patient's body, the "equipped" T cells can multiply, recognize the patient's cancer cells, and attack them.
CD19CAR T-cell therapy is a type of CAR T-cell therapy that targets the protein CD19 present in B cells. CTL019, a form of CD19CAR T-cell therapy, received a breakthrough therapy designation from the FDA in July 2014 to help expedite the development of this therapy for patients with relapsed/refractory acute lymphoblastic leukemia. This investigational therapy has resulted in exceptional treatment outcomes in some pediatric patients with leukemia, the most common type of childhood cancer.
So, what is the problem?
The CD19CAR T-cell therapy currently being tested in clinical trials to treat B-cell cancers are always switched on and not selective, meaning, they cannot distinguish cancerous B cells that have high levels of CD19 from normal B cells that have physiological (lower) levels of the same protein. Depleting B cells can be tolerated by adults undergoing this treatment who have non-CD19-expressing immune cells with established immunologic memory, but that is not the case with children. Depleting B cells in children, therefore, can result in increased risk of infection and other complications. So, researchers have been experimenting on ways to tinker with CAR T cells to make them more specific and safe. One approach is to be able to turn the CAR T cells on or off using a remote-control switch, as demonstrated by the authors of this study.
Why remote-control CAR T cells?
Seitaro Terakura, MD, PhD
"When considering CAR T-cell therapy, one of the major concerns is the 'on-target, off-tumor' effects. To reduce the toxicity, it is desirable to make the T cells switchable," says study author Seitaro Terakura, MD, PhD, research associate in the Department of Hematology and Oncology at Nagoya University Graduate School of Medicine in Japan, who co-developed a "Tet-on inducible system" that can control CD19CAR expression during therapy.
"Before the emergence of switchable CAR, suicide-gene system was the mainstay of controlling gene-modified T cells," Terakura explains. Suicide-gene system is a technology in which the CAR T cells are designed to self-destruct when an appropriate agent is administered to the patient. "However, we don't want to kill the gene-modified T cells because preparation of gene-modified T cells is always very expensive," he adds.
Further, eliminating the modified T cells altogether may also result in disease progression. "Instead, we wanted to keep those modified CAR T cells alive and controllable by administering a drug," Terakura explains.
The Tet-on inducible system
The Tet-on system is an inducible gene expression system in which the antibiotic doxycycline (which belongs to the tetracycline class of antibiotics, hence the name Tet), when administered, binds to the transcription start-site of the gene to make the protein of the gene of interest. In this particular study, the researchers engineered a reverse Tet transactivator (rtTA), which comprises a doxycycline-binding Tet-repressor mutant protein and a C-terminal activator domain from the herpes simplex virus VP16 protein.
In the presence of doxycycline, the rtTA induces the expression of CD19CAR gene, enabling the CAR T cells to go after the cancer cells. Importantly, this inducible system is "on" only in the presence of doxycycline. When the administration of doxycycline is stopped, the CD19CAR T cells are no longer functional. "Using the Tet-on system, it is possible to maintain the gene-modified T cells without killing them. We have not proved this in humans yet, but it is a potential advantage over suicide-gene technology," Terakura says.
Schematic representation of the switching "on" and "off" of Tet-CD19CAR expression by doxycycline administration and discontinuation. Image courtesy of Seitaro Terakura, MD, PhD.
The investigators performed a series of functional assays to prove that the CD19CAR T cells that were designed to respond to doxycycline, the Dox(+)-Tet-CD19CAR T cells, effectively killed a variety of CD19-positive target cells and secreted cytokines that are needed for effective tumor cell-killing. When tested in animals bearing human blood cancer cells, the Dox(+)-Tet-CD19CAR T cells showed significant antitumor activity. CD19CAR T cells that were designed to not respond to doxycycline, the Dox(-)-Tet-CD19-CAR T cells, did not have any of these antitumor effects. "I was a bit surprised when I saw a pretty good segregation between Dox(+) CD19CAR T and Dox(-) CD19CAR T effects in vivo," Terakura says.
"With some improvements over our current version, we could possibly control CAR function in a switchable manner that could be used in clinics in the near future," he adds.
"Switchable" CARs may present a solution, Dr. Carl June says
Carl June, MD
Carl H. June, MD, who pioneered CTL019, wrote a commentary on this paper, titled "Remote Controlled CARs: Towards a Safer Therapy for Leukemia." In his commentary, June, who is the director of the Translational Research Program and the Richard W. Vague Professor in Immunotherapy at the Abramson Family Cancer Research Institute at the University of Pennsylvania Perelman School of Medicine, says that the use of engineered T cells that target CD19 to treat B-cell acute lymphoblastic leukemia in clinical trials "has shown the greatest promise in the field to date." Recent updates to this technology from biotechnology and pharmaceutical companies indicate progress and promise, he notes.
The "switchable" CARs technology that Terakura and colleagues have described "may present a solution to the complications other researchers have encountered with constitutive CARs," June writes. However, an important issue with such technologies has been the amount of baseline activity or "leakiness" while in the "off" state, he adds. Another issue that June points out is that the Tet-on inducible system is made of prokaryotic and viral components, which could potentially be immunogenic and may make the patients' systems reject these modified CARs.
"Indeed, it is likely that the principles of synthetic biology combined with cellular engineering will permit the design of an array of CAR T cells that fulfill the various activity states of Boolean logic gated circuits, such as AND, OR, and NOT gates that are switchable. These next-generation designs should enable increasing precision and potency of CARs that will be controllable by the medical team," June concludes.
More on these topics soon!
Many more exciting immunotherapy advances are being presented at the Second International Cancer Immunotherapy Conference, co-hosted by the Cancer Research Institute (CRI), the Association for Cancer Immunotherapy (CIMT), the European Academy of Tumor Immunology (EATI), and the American Association for Cancer Research (AACR) in New York, Sept. 25–28. Stay tuned!
Propelling Innovative Therapeutics to Help Cancer Patients
Advances in Immunotherapy: Tackling CAR T-cell Therapy Resistance
Posted in: Journals
Tagged: Cancer immunotherapy
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What is your full Sister name?
Date you joined the order?
I started my journey on July 18, 2010 as a founding member of The Tri-City Sisters in Eastern WA. Unfortunately, The Tri-City Sisters are no more, but I was welcomed as a Novice Sister with The Portland Sisters of Perpetual Indulgence: Order of Benevolent Bliss in February of 2012 and I became a Fully Professed Sister on February 24, 2013.
What is your lay occupation?
There's a Registered Nurse somewhere beneath all of this makeup and sparkles.
I was born on the 12th.
The armpit of WA state.
I went to San Francisco Pride in 2009 and attended an event called "A Night of Ritual Mayhem with the Sisters of Perpetual Indulgence." This event exposed me to the commitment the Sisters have for their community and one another. I was especially moved by a blessing of the attendees by Sister Mary Timothy Simplicity, who is the first nun I ever approached, hugged, and had my photo taken with. I knew that after that event that I'd someday become a Sister.
Big Sister/Mother in the order?
My mother in the Order of Benevolent Bliss is Sister Helen Baak. Also, Sister Mary Timothy Simplicity of San Francisco has been integral to my journey as a Sister and we've forged a long distance mother/daughter bond throughout the entire time I've been involved with the Sisters.
I grew up in, and still live in a conservative area of WA state where the stigmatic guilt towards the LGBT community thrives. As a gay man in that environment, I've never felt like I could be my true self without somebody passing judgement. It remains a struggle to this day, at times. My basic job as a nun is to promulgate omniversal joy and expiate stigmatic guilt. The Sisters let me believe that I should be proud of who I am no matter what anyone else may tell me. It's hard for me to explain what a gift it was to be released from all of the shame-based guilt that has built up inside of me over the years, but it's easy to know that I want to share that gift with others who feel the same way that I did.
I believe there is something Divine about the human condition and I believe in being a good person.
Major projects with the Order?
My Novice Project was the creation of a Media Kit for the Order of Benevolent Bliss to use when interacting with the press or establishing relationships with new business contacts.
Other People's Words That I Find Instructive.
We are proud to have PQ Monthly as our exclusive media partner.
© 2013 Order of Benevolent Bliss, Inc. The Order of Benevolent Bliss, Inc. is a 501(C)3 non-profit corporation in the state of Oregon.