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Modified PIP protein differentiates between cancerous and non-cancerous cells
Posted: 13 March 2018 | Dr Zara Kassam (Drug Target Review) | No comments yet
A discovery sheds light on how cancerous cells differ from healthy ones and could lead to the development of new strategies for therapeutic intervention for difficult-to-treat cancers…
A discovery sheds light on how cancerous cells differ from healthy ones, and could lead to the development of new strategies for therapeutic intervention for difficult-to-treat cancers in the future.
An international team of investigators found a "stop sign"–a modified protein researchers named a PIP-stop–inside cells that are overused by cancerous cells that effectively prevents healthy ones from sorting material in the way they were designed to.
"We have discovered that breast cancer leukaemia, lymphoma and neuroblastoma cells have too many PIP-stops. This would upset protein function, and opens up a new avenue for developing drugs that block PIP-stop formation by kinase enzymes," said Michael Overduin, a University of Alberta cancer researcher and professor of biochemistry, who led the research project.
The team named the modification a PIP-stop because it stops proteins from interacting with lipid molecules called PIP.
Before making their discovery, the researchers first solved the 3-D structure of a sorting nexin protein, which is key to sorting proteins to their proper locations within the cell. Powerful magnets in the UK and in the National High Field Nuclear Magnetic Resonance Centre (NANUC), Canada's national magnet lab based in Edmonton, were then used to detect signals from within individual atoms within the protein structure.
By focusing on the protein structure, the team was able to discover the PIP-stop and see how it blocked the protein's function. The PIP-stop is a phosphate which is added to the protein surface that binds the PIP lipid, and normally controls how proteins attach to membranes.
Samples from cancer patients have too many PIP-stops, which could lead to the unregulated growth seen in tumour cells. Similar PIP-stops were found to be overused in a large number of other proteins involved in other cancer types, where they could also influence tumour growth.
"Our goal now is to design inhibitors for the overactive kinases that create PIP-stops, and to use this information to design drug molecules that block the progression of cancers, particularly those which lack effective treatments," said Prof Overduin.
Oncology, Protein, Protein Expression, Proteogenomics, Proteomics, Therapeutics
National High Field Nuclear Magnetic Resonance Centre (NANUC), University of Alberta
Michael Overduin
By Dr Zara Kassam (Drug Target Review)
Prize winner uncovers how microbiome can combat neurodegeneration
Algorithm identifies cancer drugs to treat pulmonary hypertension
Farnesol shows potential to prevent and treat Parkinson's disease
Scientists explore CA2 neuron mitochondria for memory loss targets


Visionary recording artist, producer, songwriter, philanthropist, fashion designer, and entrepreneur, Pharrell Williamsannounced additional artists and activations that will take place at SOMETHING IN THE WATER, a multi-day music festival and cultural experience on the beach in his hometown of Virginia Beach, Friday, April 26-Sunday, April 28.
Newly added artists to the sold-out festival include, Timbaland, N.E.R.D, Busta Rhymes and Fam-Lay, who will join Pharrell on stage, plus sets from Kap G, Chris Brown, Charlie Wilson and Amber Mark.
On Sunday, April 28th a special Pop-Up Church Service will be held on the beach and will feature performances by John P Kee, Kirk Franklin, Mary Mary, Tye Tribbett, Israel Houghton and The Warryn Campbell Band. This inclusive celebration is a free event for the community, which will unite & uplift, offer hope, victory, fun and faith. The revival-style experience will include gospel choirs, dance ministry, local and national worship leaders sharing the gospel and prayer offerings for our communities.
The weekend will also feature special programming from partners including Trap The Vote, who will create an interactive space that allows people to engage, consume, interact, and create around civic engagement, social change, culture, and information at 15thStreet and Pacific Avenue.
With the mission of continuing to engage the community and offer platforms for growth, More Than The Music Powered by Cox Communications will host conversations across a variety of topics ranging from Tech, Entrepreneurship, and Education, to Women's Issues, Spirituality, and Inclusion. Confirmed speakers include Deepak Chopra, Geoffrey Canada, Jon Platt, Mimi Valdés and Sylvia Rhone.
SOMETHING IN THE WATER with the support of Seatack Secondary School and Virginia Natural Gas are excited to share the news about the new community food garden at Seatack Elementary School. The food garden will augment the school's culinary initiative changing the way food is prepared in schools. The program is about integrating scratch cooking as a more sustainable food system within the schools including a teaching garden.
Timberland is planting its roots on the corner of 17th and Pacific with the Timberland Pop Up Park, inviting festival goers to relax and recharge, learn how Timberland is a hero for nature and pledge to be one themselves. Timberland will match each pledge made by planting a traceable tree in Haiti and is committing to plant 30,000 trees throughout the festival. The greenery used at the Timberland Pop Up Park, all locally sourced, will be given a new life in the vibrant Vibe District in Virginia Beach. Timberland will also be partnering with community organizations to revitalize the Seatack Elementary School community garden ahead of the festival.
Located in the heart of the ViBe Creative District will be the Old Beach Markets, an expanded eco-friendly market featuring Virginia Beach favorites – with local food, art, music and more on Saturday, April 27 in three walkable locations across the festival footprint. The special edition of these existing markets will include new local vendors.
Visitors will also be able to explore diverse expressions of public art through the SOMETHING IN THE WATER Art Walk made possible by American Express. Twelve local artists will come together to create murals themed around Virginia Beach, Hampton Roads, and SOMETHING IN THE WATER. New Orleans visual-artist Brandan Odums also known as @BMIKE2C will contribute to the landscape as well as curate the program which will be spread out throughout Virginia Beach and the SOMETHING IN THE WATER festival programming.
Verizon Up, Verizon's customer loyalty program, will offer members expedited venue entry through the Verizon Up Members Lane and 1,000 Verizon Up ticket holders will get access to an exclusive experience within the Verizon Up Members section.
Sony has teamed up with SOMETHING IN THE WATER to bring the best of Sony technology, music, movies, and gaming to the heart of Virginia Beach, including intimate live performances with Sony Music artists; meditation sessions set inside a 360 Reality Audio music dome; the hottest dance party in the galaxy with aliens from Men In Black: International; and the opportunity to discover the immersive cinematic features of the Xperia XZ3 and Xperia 10 Plus smartphones.
Uber Eats is bringing the best bites of Virginia Beach and beyond to SOMETHING IN THE WATER. The Uber Eats Window will be serving up complementary bites and beverages from beloved local restaurant partners to fans and festival-goers throughout the performances. With dishes served right on the beach all festival long, the Uber Eats Window will be open for select hours to all badge-holders.
XQ SUPER SCHOOL LIVE is a new, one-of-a-kind, immersive storytelling tour celebrating the everyday heroes transforming America's high schools and they are kicking off the SOMETHING IN THE WATER festival on Thursday, April 25, at The Z Theater in Virginia Beach with a special one-night-only performance. Combining journalism, film, art — from tour creative chair Hebru Brantley — music, and photography, it's an unforgettable night that's inspiring communities to reimagine high school so all students succeed. "From Homer to hip-hop, storytelling is one of the most powerful ways to connect people to possibilities," said Russlynn Ali, CEO of XQ. To learn more and purchase tickets, visit xq.live.
The first annual SOMETHING IN THE WATER is produced by Live Nation. The stage will be set on the beach and will feature previously announced weekend performances by Pharrell & Friends (Diddy, Missy Elliott, Usher, Gwen Stefani and Snoop Dogg), Travis Scott, Migos, Dave Matthews Band, Missy Elliott, J Balvin, Teddy Riley, Janelle Monae, SZA, Lil Uzi Vert, Diplo, Anderson .Paak & The Free Nationals, Pusha T, Kaytranada, Ferg, Jhené Aiko, Rosalía, Maggie Rogers, Mac DeMarco, Masego, Virgil Abloh, DRAM, Leikeli47, Radiant Children, John-Robert and more.
SOMETHING IN THE WATER'S mission is to unite the community and celebrate the diversity and magic of Virginia Beach. It is an opportunity to bring the best of what Pharrell has encountered around the world back to his hometown. The weekend celebrates opportunity and the chance to empower everyone from the youth to the small business owners.
Festival partners include Verizon, adidas, Sony and the City of Virginia Beach. Charitable partners include From One Hand to AnOTHER and An Achievable Dream. SOMETHING IN THE WATER is also made possible by: Uber Eats, Uber, Netflix, Array, Timberland, COX Communications, AMEX, Trap The Vote, RED HYDROGEN, Virginia Natural Gas and BILLIONAIRE BOYS CLUB.


The staff at a Salisbury care home are celebrating this week after being awarded one of the highest recorded scores in a dementia care training programme.
Laverstock Care Centre is one of three homes in the Caring Homes Group that has been selected to pilot the Bee Inspired Dementia Care programme. Four members of staff at the home, including manager Helen Pessell, are overseeing the initiative, which they have been using for the last three months.
The aim of the Bee Inspired Dementia Care programme is to further improve staff knowledge and skills so that everyone in that care setting is delivering excellent and ethical dementia care.
Jackie Poole, who devised the training package, awarded Laverstock Care Centre a 94 % score when she recently returned to validate it.
Just last year, one of Laverstock's Senior Health Care Assistants, Kelly Bartlett, was shortlisted for the Best Dementia Support Worker award at the National Dementia Awards. Although she did not win the top award, her nomination and subsequent shortlisting demonstrated her commitment to providing high quality dementia care.
Located on the outskirts of Salisbury, Laverstock Care Centre is a purpose-built home that provides residential, nursing and dementia care for up to 80 elderly ladies and gentlemen. The home is run by the family-owned Caring Homes Group, which was founded in 1994 by mother and son team, Helena and Paul Jeffery.


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Training Workers with the Skills Employers Need
February 27, 2012 at 1:35 PM ET by Tobin Marcus
Vice President Biden, joins the Community College to Career (CC2C) Tour at Davidson County Community College, in Thomasville, NC, in support of Dr. Biden and Secretary Solis' efforts to rally education and business partnerships that provide workers with skills for success.
Vice President Joe Biden, Dr. Jill Biden, and Secretary of Labor Hilda Solis make remarks at Davidson County Community College, in Thomasville, North Carolina, February 24, 2012. The Vice President Joined Dr. Biden and Secretary Solis for the last stop of their community college tour to announce the availability of $500 million to fund partnerships between community colleges and businesses to train workers with skills employers need. (Official White House Photo by David Lienemann)
Last Friday, Vice President Biden joined Dr. Jill Biden and Secretary of Labor Hilda Solis at Davidson County Community College in Thomasville, North Carolina to discuss the importance of training workers with the skills employers need right now. This visit was the final leg of a five-state, three-day Community College to Career Bus Tour that Dr. Biden and Secretary Solis took to highlight the $8 billion Community College to Career Fund recently proposed as part of the President's FY 2013 Budget.
Speaking to over 300 faculty, students, and other members of the Davidson community, the Vice President argued that America's skilled workforce is one of our greatest economic assets. But now that many American manufacturers and other businesses are growing again, too many are having trouble finding workers with the exact skills they need. That's why it's so important to forge partnerships between community colleges and businesses to train workers with the skills that employers need for jobs that are open right now. On Friday, the Vice President announced that the Administration is taking further steps to do exactly that by making available another $500 million to create and expand these partnerships as part of the Trade Adjustment Assistance (TAA) Community College and Career Training grant program.
The Administration's efforts to create and expand these training partnerships are already showing results at places like Davidson County Community College (DCCC). Thanks to a grant they received in the first round of this program, DCCC has been able to expand their partnerships with local companies to train workers with the skills they need—companies like Ingersoll Rand, which is working with DCCC to train workers with computer numerically controlled manufacturing skills, or Unilin Flooring, which is training workers in electronics engineering. And these programs are working—in fact, every single graduate of the electronics engineering program at Davidson County Community College has been able to secure a job, many of them at companies like Unilin.
"You're part of the reason why I'm so absolutely convinced that we can accommodate the good, middle-class jobs that are coming back to the United States," Vice President Biden said, discussing the ways that job training partnerships like this one are contributing to the Administration's efforts to bring manufacturing jobs back from overseas. "This is a direct channel. We're not wasting money or time here. We're training individuals for jobs that are needed and are in short supply…This is about nuts and bolts, basic dollars and cents."
Learn more about the CC2C Tour here:
Kicking off the Community College to Career Bus Tour
Report from the Road: An Ambitious Plan to Train Ohio Workers for New Jobs
A New Generation of Nurses
Tobin Marcus
Economic Policy Advisor to the Vice President
The Final State of the Union
Watch President Obama's final State of the Union address.
Read what the President is looking for in his next Supreme Court nominee.
Take a look at America's three newest national monuments.

redpajama_set_name: RedPajamaCommonCrawl


So, who's finished their Christmas shopping?
Home / So, who's finished their Christmas shopping?
That's for all you who are finished.
I'm not quite at the 'racing through the mall throwing random things in the cart in the hopes that I'll find appropriate gifts in the mess afterwards' stage, but we're getting close. It all depends on how tomorrow goes. Hardware store for tarps and a staple gun, plus whatever catches my eye. Grocery store, because I'm apparently a masochist, for all my dominant tendencies. Bulk foods store, for containers for bus driver presents. Mall, for any other random presents I happen to see (including a gift certificate to the lingerie store for the 12 year old's friend–seriously?) Stop at the post office to pick up two parcels. Stop at the liquour store, because I'm going to need it. Then home to batten down the hatches and prepare to be snowed in for a day or two. The darn thing about living on the east coast of Canada is that we get storms that come up the Eastern Seaboard, and storms that cross the country to rain (or snow) on our parade. Twice the fun.
But all this running around has seriously cut into writing time and the only thing I can do is hope I get some down time over Christmas to catch up. If I can get all the presents done this weekend (or by Tuesday, if I have to), then I can just stay home, except for one last foray to the grocery store, where I shall wield my shopping cart like a tank as I battle the hordes of Christmas zombies to get enough supplies that I and the kitten will survive for a week or so without having to venture out. (I've been stocking up on ground-to-ground missiles for a while, just in case–grocery stores are bad enough at the best of times).
In the meantime, I'd like to say a thank you to everyone who's bought a copy of Christmas Goes Analog. And if you haven't, Hearts on Fire reviewed it yesterday. The review can be found here. And it's still on sale at Loose Id for $4.49 right now, so if you like the review, grab it at that price–I think you have until Tuesday.


text:
Урания ( – "небесна") е муза на астрономията, геометрията и на християнската поезия. Изобразявана е със земното кълбо и указателна палка в ръце. Според някои митове от Аполон тя е майка на певеца Лин.

Семейство

Урания е дъщеря на Зевс от Мнемозина, а също и правнучка на Уран. Според някои източници тя е майка на певеца Лин от Аполон  или Хермес или Амфимар  син на Посейдон. Твърди се също, че Химен е бил син на Урания.

Изображение

Урания често се свързва с универсалната любов. Понякога идентифицирана като най-възрастната от божествените сестри, Урания наследява величието и силата на Зевс и красотата и изяществото на майка си Мнемозина.

Урания се облича в наметало, избродирано със звезди и държи очите и вниманието си насочени към небесата. Обикновено тя е представена с небесен глобус, към който сочи с малка тояга. Тя е в състояние да предсказва бъдещето чрез подреждането на звездите.

Източници

Древногръцки богини

redpajama_set_name: RedPajamaWikipedia


I started out years ago researching on ways to get the most out of a car engine. The most mileage, the most power, durability, the most speed, the highest return on investment. Hydrogen as a fuel has its place. Plasma has its place. Tesla magnetic motors have their place, and now Throttle Body Mod 1-A has its place.
Fully reversible, the throttle body mod is the newest way to get more out of your engine than anything I've run across for the nominal effort and maximum benefit. Check out what those who have had this done on their cars are saying on this blogsite about their experiences!
You can find out a little more at www.GadgetmansCoolCarMods.com.
If you'd like to feed the research, I invite you to chip in a dollar or two.
It'll take only a minute and it'll help a great deal.
Besides, when was the last time you were able to help a starving inventor and maybe change the world at the same time?
My name is Michael, from Perth, Western Australia. I received my modified throttle body back from Ron AKA Gadgetman on 17th August '09 and installed it straight away into my 1998 TF Mitsubishi Magna Sports 3 Liter V6. Prior to the modification I was using approx 11 liters of 91RON unleaded per 100 kms.
During the initial test drive, a flat spot was apparent during early acceleration and the engine shuddered when the car came to a stop, with RPM reducing to about 400, almost stalling the engine. This I assume was the TB re-establishing itself with all the other engine components to which it is connected with all the vacuum hoses and electrical connections.
Anyhow those symptoms soon disappeared, and the following day I had to hook up a furniture trailer to help my daughter move house which threw all calculations out the window – 15.5L/100kms.
I filled up the fuel tank again after losing the trailer to resume normal driving conditions, with the next fuel calculation revealing a slight increase in fuel consumption of .07L/100kms.
Considering such small margins, the jury is still out on whether TBM1A is effective or not on my vehicle, but I understand that it may take several hundred kilometers/miles before this modification proves it's worth.


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Attempt to aid panhandler leads to man's arrest in Alexandria
When a Rapides Parish Sheriff's deputy stopped to talk to a man who was panhandling, he discovered he had credit cards that had been reported stolen, according to a release.
Attempt to aid panhandler leads to man's arrest in Alexandria When a Rapides Parish Sheriff's deputy stopped to talk to a man who was panhandling, he discovered he had credit cards that had been reported stolen, according to a release. Check out this story on thetowntalk.com: https://www.thetowntalk.com/story/news/2018/12/20/attempt-aid-panhandler-leads-mans-arrest-alexandria/2381271002/
The United Way of Central Louisiana hosted its third Human Services Forum of the year Wednesday (Nov. 28, 2018) to talk about homelessness and panhandling. Panelists said that many of the people seen on the streets, holding signs and seeking donations, are not homeless. Wochit
Stephen Currier(Photo: Courtesy/Rapides Parish Sheriff's Office)
The sergeant was patrolling Wednesday around 11:30 a.m. when he saw the man standing at the Airbase and West Calhoun roads intersection.
More: Increase in panhandlers leads to discussion on Alexandria homeless
"Due to the recent complaints of this type of activity in the area, the sergeant stopped to make contact with the subject and offer information on local resources available to the homeless," reads the release.
The man, later identified as 64-year-old Stephen Currier, smelled strongly of alcohol and had trouble speaking and standing. The sergeant asked for identification, and Currier pulled out a Gucci wallet with credit and debit cards inside that bore women's names, it reads.
Currier couldn't explain how he had the wallet, so he was detained. He was arrested after a pat-down uncovered a "small amount" of marijuana, it reads.
The sergeant later found that Currier had traveled to the area from Shreveport. The Shreveport Police Department confirmed they had a report that the cards were stolen.
Currier was booked into the Rapides Parish Detention Center on charges of vagrancy-drunkenness, second-offense possession of marijuana and possession of stolen things.
Read or Share this story: https://www.thetowntalk.com/story/news/2018/12/20/attempt-aid-panhandler-leads-mans-arrest-alexandria/2381271002/


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About The Red Dogs
Red Dog Blog Team
Not your average crime thriller
We started Red Dog Press to feed our passion for reading thrillers with a twist. We wanted to find new voices, both authors and characters, and give them the chance to shine. As a team, we are obsessed with crime, mystery and thriller, but we tend to enjoy our dastardly tales with a twist of something else.
We're not talking about a twisty ending—that's standard. No, what makes us happy is a surprising and original angle on a familiar theme, and characters whose jobs allow them to get into scrapes without them having to follow procedure.
We love a twisty, creepy mystery, and we love a clever sci-fi. We adore edge-of-the-seat reads that keep us guessing from start to finish. We like bending genre, blending worlds, and upending tradition.
What makes you fall in love with a book? What raises it above the norm? What does it take to make you want to tell your friends? Tell us what makes you tick.
5 things we've loved this week
Spark of Joy
The Dogs' Frolics


The Give Where You Live Foundation is thrilled to present its final GMag for 2018, proudly sponsored by our Platinum Partners, AWA Alliance Bank, Fagg's Mitre 10, Ford Australia, and the TAC Towards Zero.
This issue wraps up another very busy year. We hope you enjoy catching up on all the latest from the Foundation, including the hallmark of 100 local businesses committed to the principles of the GROW initiative, an insight into our Survive and Thrive community grants at work and be sure to learn more about our upcoming events.


Keep your body in shape with this professional Sunny Health and Fitness Stepper. It has oversized footplates with slip resistant surface area so that you can work your body better. It moves up and down with a side-to-side action, made of heavy-duty steel, can hold weight up to 250 lbs. also has a built-in computer system with LCD display showing count, total count, scan, time and calories. The exercise bands help you workout your upper-body.
Excellent lower- and upper-body exercise Go up and down with a side-to-side activity Turning action tones buttocks and thigh muscles Works deep muscles without over-stressing bones and joints Adjustable resistance for variable exercise intensity Exercise bands add upper-body exercise Oversized footplates with slip-resistant surface area for safe exercise Sturdy steel building Built-in computer system with LCD display showing count, total count, scan, time, and calories Weight capability: 250 lbs. Manufacturer's guarantee consisted of - see Item Warranty area for complete information About Sunny Wellness & Fitness Sunny Wellness & Fitness has actually been importing and distributing high-quality health and fitness items for over ten years. From their head office in Los Angeles, California, they import equipment from direct sources in Taiwan and China to provide more competitive rates than the average health and fitness equipment distributor. Due to the fact that they are dedicated to excellence and stand behind the quality of every one of their items, Sunny Wellness & Fitness has actually become one of the fastest-growing business in the market. Go up and down with a side-to-side action. Sturdy steel building. Exercise bands provide upper-body exercise. Weight capability: 250 lbs. Measurements: 18.5 L x 16W x 8H inches. Manufacturer's guarantee consisted of (see item guarantee).
View YouTube Video "Sunny Health & Fitness Twister Stepper Review"


The BCR Kaweka Mountain Marathon takes place this Saturday, with 28km and 15km options, as well as the grand daddy Marathon (we have heard it is more like 47km) with over 3400 meters of climbing and descent. With its course profile, Kaweka has to be one of the harder, if not the hardest, off-road foot races in New Zealand. It is certainly the North Islands premier Mountain Marathon Race.
Chris Morrissey.If Chris is in good shape it is is hard to imagine anyone crossing the line at Cameron car park before him. Chris has past experience here in the Kaweka's and is hard as nails. His last outing was a win at the Xterra Wahia Champs. Kaweka will be a totally different kettle of fish but we expect the same result.
Hot on his tail-Julian Davidson has had some solid results at Kepler and Tararua, most recently a 5hr33, 10th place Kepler .
Jamie Stewart is a New Zealand Orienteering rep and boasts a 5hr07, 1st place Tararua Southern Crossing.
Steven Neary has been training hard (BIG mission with Mal Law a few weeks back) and will be looking to build on his solid run at the Waihi Ultra back in October.
Ruby Muir. It is very hard to look past Ruby for the win in the woman's race and finishing high up in the over-all standings. Her amazing Kepler result back in December, along with her knowledge of the course through training in the Kawekas, will make her tough to beat.
Billie Marshall has run solid times over Tararua and Tarawera in the past.
Multi-sporter Clair Sykes and Vicki Woolley, the queen of the Hillary Trail, should have a fun battle with Billie Marshall for 2nd place.
Full Entry List – let us know if we missed anyone, or YOUR picks for any of the 3 distances.
The weather is looking warm for Saturday and I am sure one way or another the weather will (as it always has) play a part, for better or worse.
All the best for those racing in the BCR Kaweka and check our Facebook page over the weekend for updates and back here next week for a race recap.
Hi Guys, thanks for supporting the race. I hope you get some exposure out of it. Sorry we took off early and missed the prize giving/ brunch. Our little girl was starting to cook and wasn't very happy about it. See you next time.


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text:
Stuttgart (region)
Stuttgart (disambiguation)
Stuttgart (/ˈʃtʊtɡɑːrt/; German pronunciation: [ˈʃtʊtɡaʁt], Swabian: Schduagert, pronounced [ˈʒ̊d̥ua̯ɡ̊ɛʕd̥]) is the capital and largest city of the state of Baden-Württemberg in southwest Germany. The sixth-largest city in Germany, Stuttgart has a population of 600,068 (October 2014) while the greater Stuttgart Metropolitan Region has a population of 5.3 million (2008), being the fourth-biggest in Germany after the Rhine-Ruhr area, Berlin/Brandenburg and Frankfurt/Rhine-Main. The city lies at the centre of a densely populated area, surrounded by a ring of smaller towns. This area called Stuttgart Region has a population of 2.7 million.
Stuttgart is spread across a variety of hills (many of them vineyards), valleys and parks – unusual for a German city and often a source of surprise to visitors who primarily associate the city with its industrial reputation as the 'cradle of the automobile'. Stuttgart has the status of Stadtkreis, a type of self-administrating urban county. It is also the seat of the State Parliament and State Government of Baden-Württemberg, the Evangelical-Lutheran Church in Württemberg as well as one of the two co-seats of the Roman Catholic Diocese of Rottenburg-Stuttgart.
This page contains text from Wikipedia, the Free Encyclopedia -	https://wn.com/Stuttgart
Stuttgart is one of the four administrative districts (Regierungsbezirke) of Baden-Württemberg, Germany, located in the north-east of the state of Baden-Württemberg, in the southwestern part of Germany.It is sub-divided into the three regions: Heilbronn-Franken, Ostwürttemberg and Stuttgart.
The districts of Böblingen, Esslingen, Ludwigsburg, Rems-Murr and Göppingen form with the city of Stuttgart the Verband Region Stuttgart with a directly elected regional assembly (Regionalversammlung).
Coordinates: 49°00′N 9°40′E / 49.0°N 9.67°E / 49.0; 9.67
This page contains text from Wikipedia, the Free Encyclopedia -	https://wn.com/Stuttgart_(region)
Stuttgart is a city in Germany, capital of the state Baden-Württemberg.
Stuttgart may also refer to:
Stuttgart (region), an administration district (Regierungsbezirk) in Germany
Stuttgart Region, a region around Stuttgart
Stuttgart, Arkansas, United States
Stuttgart, Kansas, United States
Stuttgart (soil), a type of soil in the United States
VfB Stuttgart football club
Stuttgart Observatory, astronomical observatory
"Stuttgart" (song), song by German techno band Scooter (band)
This page contains text from Wikipedia, the Free Encyclopedia -	https://wn.com/Stuttgart_(disambiguation)
Radio Stations - Stuttgart
Wildtiere in Stuttgart
source: Soundseeing Stuttgart
018 - Lifeworkcamp in Stuttgart
source: Softwarelösungen für Unternehmen mit Joachim Hummel
Episode 32: Stuttgart Streak
source: Through The Apex
[EF027] Profanes Alltags-Stuttgart
source: Erfolgsfans - Der FC Bayern Podcast
Premierenkritik I puritani in Stuttgart
source: Klassik aktuell
AK #002 (Uni Stuttgart?!)
source: Abgekuppelt
Kanzlerkandidat in Stuttgart – Was will Armin Laschet?
source: StZ Feierabend
7: Cro aus Stuttgart
source: Hausowy Popcast - Deutsch
Augsburg EINS - Stuttgart VIER
source: Feuer und Flamme - der FC Augsburg Podcast
Drei Farben für Stuttgart
Parkraummanagement Stuttgart-West
Hofmanns Erzählungen in Stuttgart
All Cops nach Stuttgart
source: Fleischhauer - 9 Minuten netto
Tourtagebuch #002 – Stuttgart
source: Im Autokino
Roland Bleinroth - Messe Stuttgart
source: Green is Good
Rückblick: Deutsches Chorfest Stuttgart
Wölferadio – Schlitterpartie, Superleague, Stuttgart
source: Fußball
The Army Today: Stuttgart Chefs
source: Army Today
Episodio #006 Stuttgart, Alemania
source: PERUANADAS PODCAST
Terje Rypdal - Live in Stuttgart
Onegin (Stuttgart Ballet)
Roger Hodgson Supertramp Jazz Open Stuttgart 2013
Stuttgart Silvester Eskalation Nur Ausl�nder Krass
Geheimprojekte Untergrundbasen Stuttgart 21
Stuttgart, Scooter
Hyper! Hyper!
Is everybody on the floor?
We put some energy into this place!
I want to ask you something... are you ready for the sound of Scooter!?
I want to see you sweat!
I said... I want to see you sweat!
Yeeah.
Excuse me! Where is the bass drum?
We need the bass drum!
It's so beautiful to see your hands in the air!
Put your hands in the air!
This is Scooter!
We want to sing a big shout to US, and to all ravers in the world!
...And to Westbam, Marusha, Steve Mason, The Mystic Man, DJ Dick, Carl Cox, The Hooligan, Cosmic,
Kid Paul, Dag, Mike VanDike, Jens Lissat, Lenny D., Sven Vath, Mark Spoon, Marco Zaffarano,... Hell,
Paul Elstac, Mate Galic, Roland Casper, Sylvie, Miss Djax, Jens Mahlstedt, Tanith, Laurent Garnier,
Special, Pascal F.E.O.S., Gary D., Scotty, Gizmo,... and to all DJs all over the World!
Keep the Vibes...
I'll have to ask you again... do you like it hardcore!?
Do you like it hardcore!?
We need the hardcore!
Come on! Come on! Come on!
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While Mayor Rick Kriseman said he would dip into reserves this year because of Hurricane Irma, he "went into the emergency reserves before Irma ever hit."
— Rick Baker on Tuesday, September 26th, 2017 in a comment during a mayoral forum
Rick Kriseman wrongly suggests city didn't dip into reserves before Irma
By Allison Graves on Friday, September 29th, 2017 at 9:00 a.m.
St. Petersburg Mayor Rick Kriseman and Duke Energy Florida President Harry Sideris talk about Hurricane Irma recovery and lessons learned from the storm. (SCOTT KEELER | Times)
St. Petersburg Mayor Rick Kriseman and former Mayor Rick Baker offered conflicting stories about the city's budget at their first mayoral forum since the August primary election.
According to Baker, Kriseman tapped into emergency reserves this year in order to balance the city's budget, despite record revenues.
Kriseman defended himself by implying that the reach for reserves had not yet happened: "We've been investing in reserves every year. If we go and have to dip into reserves for this year it will be because of Hurricane Irma and the losses that have been sustained by the city in overtime."
Baker didn't let Kriseman have the last word.
"Mr. Kriseman must be able to read the future, because he went into the emergency reserves before Irma ever hit," Baker said. "I don't know how he did that."
Many in the audience erupted into laughter and clapped for Baker. But was Baker's retort right?
Show us the money
Basically, we found that the city has tapped into reserves. The city has plans to repay the loans.
In May, the city council approved the transfer of $7.6 million to the Water Resources Capital Projects Fund to expedite infrastructure upgrades, which included projects to increase capacity at the water reclamation facilities.
Half of the $7.6 million ($3.8 million) was taken out of the city's economic stability fund — one of several types of reserve funds, and one specifically meant to cushion city coffers against economic downturns and natural disasters.
The other half came from a different pot of money: the Water Resources department's operating fund. The fund had an unappropriated balance, which, by definition, is not technically a reserve. (The Water Resources Department manages the city's sewage and almost like an independent business.)
Even though the city does not define this pool of money as reserves, some leaders consider it one and the same. In a Tampa Bay Times article, city council member Ed Montanari described the whole $7.6 million as reserves.
There are many rules that govern whether reserves from the economic stability fund can be used, and one of the more relevant ones for this fact-check is the requirement for the city to repay the $3.8 million loan.
That rules applies to reserves in the economic stability fund, but the city still hopes and has plans to replenish the whole $7.6 million loan after Water Resources department issues bonds. City officials said that would be in next couple months.
So in this case, the city would issue bonds and sell them to investors. The city will pay back the the investors who bought one of those bonds in chunks. So the city is replenishing the money with more borrowed money.
Kriseman's team considers this "paying back" the loan, but that's not how everyone in the city sees it.
Montanari told the Tampa Bay Times he didn't agree with the city's decision to take $7.6 million to pay for sewer projects.
"I don't like the fact that we're taking money from reserves and replacing it with borrowed money," Montanari told the Times. "I just want to state that on the record."
So, if the city already tapped into reserves, why did Kriseman make it seem like it hadn't?
Kriseman's campaign clarified that his comments about reserves were "strictly about the city response to Hurricane Irma."
"While the city has not yet utilized the emergency reserves for Hurricane Irma, it is very likely that we will," said Kriseman spokesperson Ben Kirby.
Kirby said the city will probably have to allocate reserves to pay city workers for the overtime they worked during the storm. He added that the majority of eligible expenses can be reimbursed by Federal Emergency Management Agency. Since Irma hit, the city requested FEMA assistance.
Baker claimed that Kriseman tapped into reserves before Hurricane Irma ever hit.
That is accurate. Under Kriseman, the city tapped into reserves early this year to cover the costs of infrastructure upgrades, which included projects to increase capacity at the water reclamation facilities. The the city plans to issue bonds to repay the loan, but there's no saying when that will happen. Furthermore, bonds are just borrowed money.
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https://stpete.granicus.com/MediaPlayer.php?view_id=14&clip_id=4120
Mayoral candidate
in a comment during a mayoral forum
This story previously misstated Kirby's job title.
Published: Friday, September 29th, 2017 at 9:00 a.m.
Researched by: Allison Graves
Edited by: Katie Sanders
Subjects: City Budget, Corrections and Updates
Email exchanges, Brigitta Shouppe, campaign spokeswoman for Rick Baker, Sept. 26-27, 2017
Email exchange, Ben Kirby, Kriseman spokesman, Sept. 26-27, 2017
Interview, Tom Greene, St. Petersburg budget director, Sept. 27, 2017
Tampa Bay Times, "St. Petersburg council sets millage rate in first budget hearing," Sept. 21, 2017
St. Petersburg City Council Consent Agenda, May 18, 2017


Dynamic and motivated professional with a proven record of generating and building relationships, managing project budget from concept to completion, designing financial guidelines, and orienting team to maintain accurate and validate documents. Experienced in effective administrative, financial, logistics, HR and communication support to SWISS and USAID donor funded projects. Adaptable and transformational with key competencies in preparing monthly financial tracking report, preparing budget template and effectively dealing with large number of partners. Proficient with HRIS and exposed to works related to selection and recruitment procedures.
• Financial control of overall project budget and regular budget monitoring and preparing budget template for 16 different partner DPOs in 16 districts.
• Ensuring accuracy and monitoring and verifying project financial document through verification all bills and invoices including supporting documents against the approved activities and submit for approval of 16 different DPOs along with one consortium partner.
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Providing administrative support for drafting correspondence, project team meeting minutes, maintaining files and records in organized manner for future reference.
Support the project team in updating/ drafting project planning, M& E plan tools, monthly team scheduling and providing information and data compilation for report as per project needs and priorities.
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Orienting partner on financial documentation and monitoring their monthly financial report along with supporting documents ensuring quality and accuracy suggesting for necessary improvements and orienting on maintaining financial documents.
Preparing monthly budget forecast, treasury forecast, rolling forecast, Checking monthly budget monitoring and utilization and assisting Project Manager in budget modification and preparing annual procurement and movement plan.
Assisting the human resource and administration department to streamline overall filing and documentation related tasks.
Preparing personal files for all staffs and regularly updating information in updated manner as per checklist for future reference along with updating it in HRIS system.
Regularly communicating with existing staffs for providing complete documents as per organization policy.
Accessing all recruitment documents and managing them in proper files as per position and year maintaining uniformity in all requirements and documenting as per recruitment policy.
Archive and keep the CVs collected in each recruitments by creating a separate folder or file for future reference and needs to identify potential candidate for future matching position.
Review of existing HR and admin form and consulting with HR and supporting in selection and recruitment process.
Data entry of different task assigned by the organization provided by various clients maintaining accuracy with proper retrieving of data as per the training provided.
Conducting regular weekly team meeting along with organization representative for sharing update of weekly work, addressing issues faced by team members, sharing weekly Cloudfactory values and setting weekly action plan.
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Completed BBIS with elective subject as Information security.
Completed online trainings on Excel 2010 - Applying Basic Data Formatting- Dec23, 2017 ;Planning and Implementing a Successful Voucher Program Simulation by Mercy Corps- Dec 20, 2017; Introduction on Monitoring & Evaluation by International Rescue Committee (IRC)- Nov 8, 2017; Module 1: Introduction to Project Management by Last Mile Learning- Nov 8, 2017.
Participated in One day First Aid Training by Red Cross in Humanity and Inclusion office.
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This basic single-line Lavi Qtrac Call Forward System represents technology at its best for speeding customer service and increasing efficiency. With a simple button-push on Qtrac's wireless remote, agents instantly alert the next waiting customer and clearly and quickly guide them, via the LCD display, to the next open service position using both audio and visuals. This system includes 5 remotes (for five tellers or agents), a 22" monitor, 5 wireless remotes with AC adapter and all software. The custom end product ships from the factory ready to go as for example, window number #4 is to the left, window #1 is to the right. The desired slideshow preparation must be provided by customer, and can include whatever marketing messages desired. Benefits: Increases Customer Satisfaction; Eliminates agent "down time" due to inefficient queuing processes; Decreases average wait time by optimizing customer throughput; Works independently from your other networks, keeping proprietary information safe and secure; Increases impulse purchases. Features: Promotional stills or video can play between queuing prompts to keep customers engaged; Up to 6 different interrupt modes allow media to play full-screen, split screen, or picture in picture; Use the Qtrac LCD display or connect your own monitor; Choose Qtrac's pre-installed alerts, voices, and images, or create your own; View your configured set-up in real time before going live; Wireless technology makes it easy to add or move station remotes – up to 99; Wirelessly control numerous peripheral devices such as station lights or security doors; Control up to 3 different queues from a single remote with a simple push of a button. Your cost for purchasing this Qtrac single-line basic system is $3,342.65, which includes the factory charge for customizing it for your particular situation. Please call U.S. Bank Supply at 805-218-6106 if this system interests you - and we will be your partner in the process of getting you up and running..
This basic single-line Lavi Qtrac Call Forward System represents technology at its best for speeding customer service and increasing efficiency. With a simple button-push on Qtrac's wireless remote, agents instantly alert the next waiting customer and clearly and quickly guide them, via the LCD display, to the next open service position using both audio and visuals.