text:
Ghosts I Have Seen, and Other Psychic Experiences
Ghosts I Have Seen, and Other Psychic Experiences is a book by Violet Tweedale published in 1919 in which she documented her psychic experiences.
1.1 Chapter I, Silk Dress and Rumpus
1.2 Chapter IV East End Days and Nights
1.3 Chapter V The Man in the Marylebone Road
1.4 Chapter IX Pompey and the Duchess
1.5 Chapter XXIII Auras
(Full text multiple formats)
Today I heard music which I had known and loved in the happy, careless long ago, and whilst I was lost in a dream of half-forgotten bliss I smelt the fragrance of mimosa flower.
Chapter I, Silk Dress and Rumpus[edit]
Today I heard music which I had known and loved in the happy, careless long ago, and whilst I was lost in a dream of half-forgotten bliss I smelt the fragrance of mimosa flower. I cannot describe the sensations of joy that thrilled through my whole being. An involuntary moving of the spirit, an emergence into a dream world, described by the Greeks as "ecstasy." The music fashioned the invisible link, and I was back again on a hillside where the mimosa grew in native abundance. Now, one thinks of France only as a hideous battle plain, but memory, the true dispensator of time, is never bound by years. She keeps ever fresh, in glowing colors, those ideal moments that gather up the utter joys of life into one divine sheaf of memory.
I have written in this book of the miracles I have seen. Some of them any one can see, others are reserved for the delectation of the few. I have written of strange visitants from other realms, and of that vivid illumination which at moments lays bare the hidden springs of life, when the spirit emerges beyond the limit of human thought, and familiar things, beyond the horizon of life, and touches a sphere beyond immortality. It is a condition that the grave has nothing to do with, a beholding beyond the frontiers of the soul.
I have written of the spiritual life, for without this spiritual life a palace would be no wider than a tomb. The vastness of the spirit world defies description. It can choose its own pathways, and any one of these long, long roads leading to the great mysteries.
It is now almost universally acknowledged that psychic experiences, of a specific nature, occur at certain times to certain people, that are not explicable by any known science. Generally, they are experiences which point to the continuity of the human consciousness with a wider spiritual environment, from which the normal man is shut off.
I hope that I have never tried to convince others of the truth of these experiences. If I have done so it has been unconsciously done. I am absolutely persuaded that such phenomena can only become convincing when personally experienced. Such matters ought not to be accepted on hearsay. It is mere folly for one woman to attempt to demonstrate to another the existence of the human soul. The most that A can communicate to B, of any part of her own experiences, is so much of it as is common to the experiences of both.
I have proved conclusively to my own consciousness that I am linked up with a wider consciousness from which, at times, such experiences flow in.
I know my soul to be in touch with a greater soul, which at moments enters into communication with me, and opens out a vastness which it is impossible to translate into words, and which annihilates space and time.
I have had my vision, and I know. Therefore I am quite unmoved by criticism or ridicule.
Her eyes, large and pale green, dominated the countenance — wonderful eyes in their arresting, dreamy mysticism.
Chapter IV East End Days and Nights[edit]
At that early period some one happened to mention to me that a certain Madame Blavatsky had just arrived in London, bringing with her a new religion. My curiosity was at once fired, and I set off to call upon her. I shall never forget that first interview with a much maligned woman, whom I rapidly came to know intimately and love dearly.
I asked her to explain her new religion, and she answered that hers was the very oldest extant, and formed the belief of five hundred million souls. I inquired how it was that this stupendous fact had not yet touched Christendom, and her reply was that there had never been any interference with Christian thought. Though judge of all, Christianity had been judged by none. The rise of Japan was a factor of immense potency, and in time would open out a new era in the comprehension of East by West. Then the meaning would flash upon the churches of the words, "Neither in this mountain nor yet at Jerusalem."
I explained to her my difficulties, which she proceeded to solve by expounding the doctrines of reincarnation and Karma. They jumped instantly to my reason. I there and then found the Just God, of whom I had been in search. From that day to this I have never had reason to swerve from those beliefs. The older I grow, the more experience I gather, the more I read, the more confirmed do I become in the belief that such provide the only rational explanation of this life, the only natural hope in the world to come. I have offered those beliefs to very many people whom I discovered to be on the same quest as I had been. I have never once had them rejected by any serious truth-seeker, and I have seen them passed on and on by these people to others, forming enormous ramifications which became lost to view in the passage of time and their own magnitude.
It is thirty years ago since I became a convert to Spiritualism. At that time I made up my mind that I would attend fifty séances, and if, out of that number, I did not come across one that I could be absolutely certain was genuine I would attend no more. Spiritualism, in itself, never interested me, but I was determined to see for myself if there was really anything in it. I attended twenty-nine séances before I happened on one that was absolutely convincing. Several had been almost convincing, but a loophole for fraud had remained, and so long as that was the case I persevered.
What was the secret of Helena Petrovski Blavatsky's instant success? I have no doubt that it lay in her power to give to the West the Eastern answers to those problems which the Church has lost.
"The Secret Doctrine" written by Blavatsky proved a mine of wealth, and I read the volumes through seven times in seven different keys. The works of A. P. Sinnett, text books then, and now brought up to date by expanding knowledge, were extremely helpful. For advanced students "The Growth of the Soul" is unsurpassed. A very short time elapsed before mental food was supplied for practically every branch of mysticism and occult development, and students flocked into headquarters from all parts of the world.
Chapter V The Man in the Marylebone Road[edit]
I went one summer morning to see an old man who lived in the Marylebone Road. I was shown up into a sunny little room on the first floor. It had neither carpet, curtains nor window blind, and it looked on the street. The furniture consisted of a plain, uncovered deal table in the middle of a clean planked floor, and eight plain uncovered deal chairs were ranged round the walls... "Please make those four chairs opposite to us cross the floor and mount on to the table," I said. The old man drew his chair quite close to mine, "Then give me your hand." I removed my glove and did as he asked... "I am not a hypnotist, but I see you have power. You may as well lend me some. You are young, and I am old.".. At that second my attention was distracted by a grating sound... I saw the four chairs leave the wall and advance towards the table... There appeared to be four invisible hands at the work. Then, one by one, they were neatly balanced, one on the top of the other, on the table... "Good boys! good boys," I heard him murmur. "How is it done?" I asked him. He shrugged. "The Petris (spirits) do it..." "Then ask 'the Petris' to put the chairs neatly back again." "The Petris" performed this feat very expeditiously...There was no loophole here for fraud, not a wire, or string, or any human manipulation...
Chapter IX Pompey and the Duchess[edit]
I remember Lilian, Countess of Cromartie, telling me of a strange incident that once happened to her. She was walking alone one bright summer morning in Windsor Great Park. Suddenly she saw an amazing looking creature loping slowly towards her. It resembled an enormous hare. That is to say, its legs and head were those of a hare, but its size was that of a goat, and its horned head was half-goat, half-hare. This creature, loping without any fear, and with a hare's movement straight towards her, caused her to pause. She stood still and breathlessly waited its approach. It passed quite close to her, and as it did so she struck at it with her parasol. Instantly it disappeared. Chapter IX
The two little girls heard some bushes behind them rustling, and a huge creature, half-goat, half-man, emerged and leisurely crossing the road in front of them plunged into the woods beyond and was lost to sight. Both children... screamed loudly.
This couple were traveling in the wilds of Greece, and one night they wandered out together on to a bare mountain side. Sitting down to rest they were enjoying the beauty and utter loneliness of the moonlit scene, when they suddenly heard the galloping of many horses' hoofs approaching them. This astonished them greatly, as they were in so wild and unfrequented a part of the country. There was no road near them, and it seemed strange to hear horses galloping so fast on such rough ground at night, even though there was a moon. Husband and wife stood up immediately in order to show themselves. The sound suggested a headlong rush, and they feared that in another second a whole regiment might ride over them.
They had not long to wait. A troop of creatures, half-men, half-horses, tore past them, helter-skelter. Fleet and sure-footed they thundered by, and they brought with them the most wonderful sense of joy and exhilaration. Neither the Grand Duchess nor her husband felt the smallest fear; on the contrary, both were seized by a wild elation, a desire to be one of that splendid legion. The thundering of their hoofs spread over the hills, and died away into the distance.
I happened to hear the Grand Duchess tell of her weird experience... There were several people in the room whilst the Grand Duchess was unfolding, in the most impressive manner, this strange event... She told us that when a child of seven years old, she had passed through some minutes of such absolute terror, that as long as she lived she would never forget... With another child... she was playing one summer morning out of doors. After a little while the nurse rose from her seat amongst the heather, and wandered away a short distance, out of sight but not out of hearing... the two little girls heard some bushes behind them rustling, and a huge creature, half-goat, half-man, emerged and leisurely crossing the road in front of them plunged into the woods beyond and was lost to sight. Both children... screamed loudly. The nurse ran back to them, and... scolded them... No such animal existed, such as they described, an animal much bigger than a goat, that walked upright, and had but two legs, and two hoofs, that was covered with shaggy brown hair from the waist downward... the smooth skin of a man from the waist upward! The nurse bade them come home at once, and as they gained the road Miss Wemyss pointed down into the dust. Clearly defined was the track of a two-hoofed creature that had crossed at that spot. The nurse stared for a moment... then... they all ran. She never took her charges near that spot again.
In after years, when grown up, she realized from pictures that what she had seen was a Faun or Satyr. Such pictures or statues always sent a thrill of horror through her. She attributed this apparition to the fact that she and her companion were playing close to the site of a Roman camp, and the road was an old Roman road. She went on to say that the Grand Duchess had given her courage to tell this incredible story. It was as absolutely real to her as was the passing of the Centaurs to the Grand Duchess... She never mentioned it to any one, as she felt that no one would believe her. She could always smell again the scent of summer, and the odor of pine trees, and hear the trickling of water from a tiny stream. She could always see a wide, white road, ribbon-like stretching away to the horizon.
She believed that there was a real world beyond the glamour and vision of our ordinary senses, and sometimes this veil was lifted for a few seconds. She believed that much of the tradition of mythical creatures represented solid fact, and that it was possible there were failures of creation still extant. Again, might there not be races fallen out of evolution, but retaining as a survival certain powers that to us appear miraculous.
What is an aura? You will see them glittering round the heads of saints, and of The Christ in church windows.
Chapter XXIII Auras[edit]
I was born with the power to see auras, and I had attained to quite a grown-up age before I discovered that every one could not see them.
What is an aura? You will see them glittering round the heads of saints, and of The Christ in church windows. You will see them painted round the head of the Blessed Virgin, round the head of the Infant she holds, but, indeed, auras are the property of all, however humble and lowly. Nothing that has life, be the spark ever so faint, is without its astral counterpart, its tenuous surrounding atmosphere.
Habitual seeing of human auras has made me no more or less observant of them than I am of the human face.
If I am asked by any one to say what her aura looks like, I do so to the best of my ability, but at that complacent moment it is a very tame affair, much like the aura that any one may see surrounding a lighted candle. A medley of prismatic hues, no color predominating.
Where auras become really interesting is in a room full of people. I look down to the far end of the room where a group is seated talking. I cannot hear what they are saying, but I can tell at once whether the conversation is harmonious or otherwise. Often there will be one member of the group whose aura is very disturbed. It will emit flashes of brilliant red as he talks vehemently.
Many people seem to think that the power to see auras must be very useful in helping one to distinguish between friends and foes, but such is not really the case. Auras exemplify individual character, not individual predilections, and some of my friends being very bad characters, indeed, have shocking auras. I had one great friend who, at the beginning of our acquaintance, spent much of his time in prison, which was really a blessing for his ill-used wife. His aura was literally in tatters, just a little irregular circle of rags and patches. I had just succeeded in making him sober, by insisting constantly and most seriously that he was "a cut above the public-house," and much too superior a man to mix with such degraded companions, when the war broke out. He went to the front, and on his first return to Blighty, badly gassed, he came at once to see me. I really felt a sort of personal pride in him, and an actual sense of personal possession in his enormously grown aura... Here, indeed, was an infant soul that had begun to develop on the right road, and the tattered aura of rags and patches had become a neatly trimmed little halo round his poor tired head.
I am sorry that I have had no opportunity of seeing President Wilson's aura, the man who has turned his face towards a heavenly ideal, and is scattering the seed amongst all the nations. When a man sets out on such a long radiant path, he will carry visibly in the daylight an illuminated brow. He has brought to us the vision without which the people perish.
I suppose I must have enemies. They say every one has, but they have never made me aware of their enmity, perhaps because there is no room in a very full heart to receive aught but love. If I were to single apart one outstanding feature in my life, it would be the wonderful kindness and friendship that has been given to me. Ah! how easy that makes it to write lovingly of others.
Behind all this lies the master passion of the born mystic for liberation. The constant ache and urge for real freedom, and power to be victorious over all circumstances. At home in all scenes, restful in all fortunes. There is the urge of the soul for universality of contact with all humanity, independent of race, color or creed. The urge of the spirit to smash the confines which pinion it down to earth.
I think it is really the urge of reincarnating life still clinging to me. The knowledge that my immortal soul must return to the House of Bondage, until perfection is reached, and there is the going out no more from the Father's House, from a freedom which has become supreme.
Ageless Wisdom teachings
Violet Tweedale
Retrieved from "https://en.wikiquote.org/w/index.php?title=Ghosts_I_Have_Seen,_and_Other_Psychic_Experiences&oldid=3053355"


Rueda, or more accurately Rueda de Casino or Salsa Rueda is a group style of Salsa, with the moves more closely asssociated with Cuban Style of Salsa. That is probably because Rueda started in Cuba in 50s. Rueda is danced with groups of 4 - 10 couples, and is a little like a progressive dance - many Rueda moves advance the follower to teh next leader. Rueda is a whole lot of fun!
The player below is from the TV Series Latin Dance Alive, and it is a great introduction to Rueda. When you are ready please select from the menu above to see instructional and performance Rueda clips. Wherever you see a player like this one, the clips will play through so you can enjoy a lean back experience!


More than six years into his career as a State Senator, Mark Herring believes it's now time to transition into a higher office—as Virginia's next Attorney General.
This entry was posted on May 6, 2013, 2:34 pm and is filed under Candidate Profiles. You can follow any responses to this entry through RSS 2.0. You can leave a response, or trackback from your own site.


ASEAN countries need to strengthen co-operation and share their experiences to ensure they can lead the way on next-generation 5G wireless technology.
So said Deputy Prime Minister Vu Duc Dam at the conference on 5G & Development of Digital ASEAN in Ha Noi on Friday.
According to the Deputy PM, facing the changes and advancement of technology, the ones who are proactive and pioneering will be the more successful afterwards, Dam said.
Deputy PM said the initial steps towards developing a new technology are always challenging. Therefore, governments should take the initiative in supporting enterprises to minimise risk.
He stressed the need to boost innovation and address shortcomings related to information security and safety.
Dam also suggested delegates try to develop a suitable roadmap for the development of 5G, including identifying opportunities and challenges and putting forward solutions.
Speaking at the conference, Minister of Information and Communication Nguyen Manh Hung highlighted the significant role of 5G network development.
The digital economy, with its new business models and methods, is creating opportunities for organisations and enterprises. New technologies will enable better connectivity across supply chains, reducing logistics and business costs.
"5G will be the most important part of the digital economy infrastructure thanks to its greater bandwidth, higher speeds and lower latency," Hung said.
According to the minister, Viet Nam will be one of the first countries in the world to roll out 5G and is willing to co-operate with other ASEAN countries to establish joint ventures and factories to make the necessary IT equipment.
He said that from the beginning of 2019, the Ministry of Information and Communication (MIC) had already licensed local carriers to test the technology in Ha Noi and HCM City, noting that the country is also focusing on developing other 5G-based technologies and equipment.
Hung stated ASEAN members must focus on building digital infrastructure and working together closely to shorten the development gap with advanced countries.
The minister suggested each ASEAN country implement an initiative and share the results with other countries, improving the efficiency of resource use and promoting the common strength of the region.
With regards to the 5G development situation around the world, Cristian Gomez, director of spectrum policy and regulatory affairs for the Asia-Pacific region at industry group GSMA said the application of the technology is progressing rapidly. Countries are looking for efficient ways to improve mobile connectivity and provide the best quality for customers. 5G is being applied quickly in the US, Europe and some Asia-Pacific countries such as Japan, the Republic of Korea and China.
"The Southeast Asia region with its fast-growing economies will benefit a lot from 5G technology in some areas such as robots, the manufacturing industry and self-driving cars," Gomez said.
He said that in a smart city, 5G-connected cars can avoid traffic jams and reduce energy consumption.


text:
Editorial: Fourth of July is a time of hope and joy
Once again, our nation prepares to celebrate our independence and our commitment to the rule of law, to the people's right to participate in their government, and to the transformative ideal that authority flows from the people. Or as Abraham Lincoln so eloquently described it "a government of the people, by the people, for the people."
When our founding fathers signed the Declaration of Independence, they set in motion a grand experiment in democracy and self-government. Nearly two-and-a-half centuries later, the fate of that experiment remains in the hands of each and every American. It is a responsibility that has been passed from one generation to the next.
For a democratic government to function, it needs the full participation of the people. We Catholics are called to participate in our democracy not only as a civil obligation but also as part of the mission of our Lord.
"An authentic faith … always involves a deep desire to change the world, to transmit values, to leave this earth somehow better than we found it," Pope Francis wrote in his apostolic exhortation "Evangelii Gaudium" (The Joy of the Gospel). "If indeed 'the just ordering of society and of the state is a central responsibility of politics,' the Church 'cannot and must not remain on the sidelines in the fight for justice.'"
We live in a time that can seem saturated with cynicism. But as Catholics, the U.S. bishops remind us in their document "Forming Consciences for Faithful Citizenship," that we can bring our hope and joy in Christ to the debates of important public issues, to our commitment always to promote the common good.
There are some who resent people of faith bringing their perspective to such debates, who feel any position that springs forth from a foundation of faith is suspect.
But in their wisdom, the founding fathers enshrined in the Constitution religious freedom, an individual's right to believe as they wish – or not to believe – without government interference. The result is a nation with an astounding religious diversity, each faith and denomination bringing a different perspective on the moral and ethical issues facing humankind and enriching the whole culture.
Catholics certainly have much to offer as "we the people" endeavor to create a more perfect union. The Church has a long history of defending the dignity of every human being, of caring for the marginalized, of providing an education for children that will enhance the rest of their lives, of caring for the sick, of welcoming the stranger, of protecting our religious freedom. We are called to bring that history, imbued with Church teaching, to the public square.
As we consider the many difficult issues facing our country, the bishops urge us to form our conscience based on four principles of Catholic social doctrine: the dignity of the human person, the common good, subsidiarity and solidarity.
"With this foundation, Catholics are better able to evaluate policy positions, party platforms, and candidates' promises and actions in light of the Gospel and the moral and social teaching of the Church in order to help build a better world," the bishops wrote in "Faithful Citizenship."
In our political involvement, whether in our exercise of the right to vote or a deeper involvement, we Catholics should be "guided more by our moral convictions than by our attachment to a political party or interest group," the bishops wrote in "Faithful Citizenship." "When necessary, our participation should help transform the party to which we belong; we should not let the party transform us in such a way that we neglect or deny fundamental moral truths or approve intrinsically evil acts. We are called to bring together our principles and our political choices, our values and our votes, to help build a civilization of truth and love."
The Fourth of July is a national holiday filled with hope. It reminds us of the power we have to make the world a better place, the value of our voice, and our responsibility to use that power, that voice, to shape a country that is fair and just. That is a goal fully supported by Catholic teaching and by our love for Christ.
PrevPreviousTennessee bishops praise court's ruling in abortion case
NextNew York State Catholic Conference 'troubled' by court's gun law rulingNext

redpajama_set_name: RedPajamaCommonCrawl


Fortune telling in the magazine, is a guilty pleasure to read for some people. Although most people don't believe in it, it is still very interesting to read just for the fun of it. Who doesn't feel curious about themselves, what does their own birthdate and personal characteristics tell about them. Other than the more famous western zodiac and the Chinese zodiac, Indonesian, especially the Javanese have their own zodiac, the name is neptu.
Kentrung (I always know it as kencrung, however people online call it kentrung, how come?) is a musical instrument that is native for Indonesia (isn't it? I actually don't know much). The young brother of guitar and ukulele (4 strings).
Back then when I was a first year, I make this program to calculate things related to birthdate and Javanese Dating System. I think it will be nice if I compile the calculations and explain the logic. Hopefully I can also explain how Javanese Dating (the month and the day, not the lover kind) works.


As a company, Malaka9's objective remains solid: to give the best solutions for our costumers worldwide. We invest in our people and our technologies, and consistently deliver quality, competitively priced products to our customers.
Malaka9's culture promotes and inspires our team of designers, engineers and developers to be at the top of their game. We've created an environment where talents are recognized and collaboration is valued.
We invite you to explore the opportunities available with us!
As a System Analyst, you will analyze and design applications using object oriented concepts.
¤ Proficient in UML Design and Unified Process.
¤ Strong capabilities in PHP / Java.
¤ Experienced with GNU/Linux OS.
As a Programmer, you will develop web-based applications using the latest technology.
¤ Familiar with GNU/Linux Operating System.
¤ Familiar with UML Design (highly recommended).
¤ Strong interpersonal and excellent communications skill.
¤ Capable to work hard and under pressure.
¤ Having high integrity, dedicated, and team work oriented.
¤ Good command of English and Computer literate is a must.
¤ Eager to learn new skills.
only sort-listed candidates will be contacted.


Thanks all, I'm happy to be back in green.
If I knew in college what I know now this would be my career path. Also, best of luck on your candidacy.
We're going to be playing another Warframe Wednesday 2 weeks from now on the 24th of April. Also special thanks to @MadCast: Kitty Stark who created a Discord Role for Warframe.
That's awesome; 1 week left!
Hello Operators, I'm putting up this poll to gauge interest in a MadCast event focused around WarFrame. A lot of MadCast members have played this game and I'm sure we've all heard of it. I recently picked it up and think that an event would be fun. There are a lot of options available such as relic farming, WF/weapon leveling, reputation/event grinding and introducing people to a new game (if we have someone new). This would great way to play with MadCast members in a mature and established game and for those that haven't tried it a new game. WarFrame is free to play and content can all be earned in game.
Hello I'm Aeryx and I'm re-applying to be an RFM. Several months ago I stepped down from being an RFM do to some real life work issues (my section was understaffed and I was picking up a lot of the work to keep it going). I've since filled 2 vacancies in my section (and interviewing for a 3rd) so I've got back my work-life balance goal. I hope to step back into our website awards, League of Learning, some recruiting and create a Wednesday event for Warframe. I've always made it a priority to stay active in the MadCast community even when life was busy. I love our community and the people that make it great. I've led a lot of MadCast events and I look forward to setting back up as an admin (if selected). Something from my last application that still holds true "I have plenty of experience being a supervisor both at work and at home; though I think at home is probably more challenging with my children...I enjoy the strategic and enterprise development side of management (though I'm still very involved in day-to-day operations) and feel that I can apply that here with the great majority of day-to-day decisions in MadCast." Thank you for your consideration.
Congrats!!!!!! Well deserved @MadCast: Epic and @MadCast: RedJustice. I'm very happy for you both.
I'd like to nominate @MadCast: Support Welfare for the Leveler Assistance Recognition for spending hours helping me get acclimated to WarFrame. I'd like to nominate the entire SFM team who contributed to this thread for the Copious Content Creator Award. I can only read what @MadCast: RedJustice wrote and @MadCast: Epic's discord posts but it was well done and entertaining and I'm sure a lot of work for all.
It is a good game and fun to mess around on. You can be on for hours or just a few minutes depending on your schedule. If you're looking for something new to do hop and and join us.


text:
Keith B. Ward
Keith is an Affiliated Faculty member at George Mason University. He received his B.S. in Physics from Texas A&M and his Ph.D. in Biophysics from the Johns Hopkins University. He was on the Chemistry Faculty at the University of Wisconsin before serving as a civilian scientist for the US Navy, DHS, and the FBI Laboratory. Since retiring, he occasionally provides technical assistance to Human Rights Watch and Amnesty International, specializing in chemical and biological defense topics.
He received his BS in Physics from Texas A&M and his PhD in Biophysics from Johns Hopkins. He is currently Affiliated Faculty at the Departments of Molecular and Microbiology and Bioinformatics and Computational Biology at George Mason University. He previously taught as a Professor of Chemistry at the University of Wisconsin and served as chair of the Biomolecular and Biosystems group within the Cognitive, Neural, and Biomolecular Science and Technology Division at the Office of Naval Research.
Recent Posts by Keith B. Ward
La létalité du gaz de chlore - Une explication possible du nombre élevé de victimes et décès à la suite des attaques du 7 avril 2018 à Douma, en Syrie
The Lethality of Chlorine Gas – A Possible Explanation for High Casualties and Deaths Following the April 7, 2018 Attacks in Douma, Syria


THOUSAND OAKS, Calif., Feb. 28, 2019 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced that new data from its early-stage oncology pipeline will be presented at the American Association for Cancer Research (AACR) Annual Meeting in Atlanta, March 29 – April 3, 2019.
"At Amgen, we are searching for and finding answers to incredibly complex questions to advance care and improve lives for cancer patients," said David M. Reese, M.D., executive vice president of Research and Development at Amgen. "In a significant milestone in the oncology community, we will share the latest preclinical data from our KRASG12C inhibitor, AMG 510. KRAS has eluded targeting despite more than 30 years of industry and academic research. Our program is the first to reach the clinical stage, which will evaluate its potential against a target that is easily identifiable and present in a wide range of solid tumors."
For the first time, preclinical data will be presented on AMG 510, a first-in-class investigational KRASG12C inhibitor being evaluated for the treatment of solid tumors. Data at the meeting will also showcase Amgen's novel bispecific T cell engager (BiTE®) platform, including preclinical data evaluating the use of AMG 757, a DLL3-targeted BiTE® molecule, in resistant subtypes of melanoma. Additional research to be presented will include preclinical data evaluating the use of Amgen's intravenous investigational MCL-1 inhibitor, AMG 176, in combination with standard of care therapies in acute myeloid leukemia.
The subject of more than three decades of research, RAS proteins make up the most frequently mutated gene family in human cancers.1,2 Within this family, KRAS is the most prevalent variant and is particularly common in solid tumors.2 A specific mutation known as KRASG12C accounts for approximately 12 percent of all KRAS mutations across tumor types.3 Amgen is exploring the potential of KRASG12C inhibition across a broad variety of tumor types.
Amgen is committed to helping patients take on some of the toughest cancers, such as those that have been resistant to drugs, those that progress rapidly through the body and those where limited treatment options exist. Amgen's supportive care treatments help patients combat certain side effects of strong chemotherapy, and our targeted medicines and immunotherapies focus on more than a dozen different malignancies, ranging from blood cancers to solid tumors. With decades of experience providing therapies for cancer patients, Amgen continues to grow its portfolio of innovative and biosimilar oncology medicines.
Our results may be affected by our ability to successfully market both new and existing products domestically and internationally, clinical and regulatory developments involving current and future products, sales growth of recently launched products, competition from other products including biosimilars, difficulties or delays in manufacturing our products and global economic conditions. In addition, sales of our products are affected by pricing pressure, political and public scrutiny and reimbursement policies imposed by third-party payers, including governments, private insurance plans and managed care providers and may be affected by regulatory, clinical and guideline developments and domestic and international trends toward managed care and healthcare cost containment. Furthermore, our research, testing, pricing, marketing and other operations are subject to extensive regulation by domestic and foreign government regulatory authorities. Our business may be impacted by government investigations, litigation and product liability claims. In addition, our business may be impacted by the adoption of new tax legislation or exposure to additional tax liabilities. While we routinely obtain patents for our products and technology, the protection offered by our patents and patent applications may be challenged, invalidated or circumvented by our competitors, or we may fail to prevail in present and future intellectual property litigation. We perform a substantial amount of our commercial manufacturing activities at a few key facilities, including in Puerto Rico, and also depend on third parties for a portion of our manufacturing activities, and limits on supply may constrain sales of certain of our current products and product candidate development. We rely on collaborations with third parties for the development of some of our product candidates and for the commercialization and sales of some of our commercial products. In addition, we compete with other companies with respect to many of our marketed products as well as for the discovery and development of new products. Further, some raw materials, medical devices and component parts for our products are supplied by sole third-party suppliers. Certain of our distributors, customers and payers have substantial purchasing leverage in their dealings with us. The discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. Our efforts to acquire other companies or products and to integrate the operations of companies we have acquired may not be successful. A breakdown, cyberattack or information security breach could compromise the confidentiality, integrity and availability of our systems and our data. Our stock price is volatile and may be affected by a number of events. Our business performance could affect or limit the ability of our Board of Directors to declare a dividend or our ability to pay a dividend or repurchase our common stock. We may not be able to access the capital and credit markets on terms that are favorable to us, or at all.
Cox A, et al. Drugging the undruggable RAS: Mission Possible?. Nature Reviews Drug Discovery. 2014;13(11):828-851.
Fernandez-Medarde A, Santos E. Ras in Cancer and Developmental Diseases. Genes Cancer. 2011;2(3):344-358.
Hobbs G, Wittinghofer A, Der C. Selective Targeting of the KRAS G12C Mutant: Kicking KRAS When It's Down. Cancer Cell. 2016;29(3):251-253.


text:
Home / Reviews / PlayStation
Sony's PlayStation VR2 headset is coming in early 2023
The confirmed launch window was announced by PlayStation on social media
23 August 2022 / 11:16 BST 2 November 2022 / 16:58 GMT
Sony shares an early look at new PlayStation VR 2 features
Ahead of the PlayStation VR2 launch, Sony has shared a glimpse at new features such as a see-through view and cinematic mode.
26 July 2022 / 15:53 BST 2 November 2022 / 16:58 GMT
Sony is launching a PS Plus reboot in June with over 700 new games
A revamped PlayStation Plus is on the way
Lego collabs with PlayStation for Horizon Forbidden West Tallneck set
If there's a collab to be had, chances are Lego is all over it – latest on the release slate is this set inspired by the incredible world of Horizon Forbidden West. It's a large 1,222-piece set with the usual adults-only sign – the box says it's for 18+ builders only. It's not a plaything, […]
15 February 2022 / 13:04 GMT 29 April 2022 / 17:10 BST
Stuff's Best Games Ever: The 25 best PlayStation games of all time
All the essentials from over a quarter century of play
8 June 2021 / 09:46 BST 16 November 2021 / 18:35 GMT
Sony's new DualShock 4 attachment adds programmable back buttons to the PlayStation gamepad
Baby got back
18 December 2019 / 11:29 GMT 5 November 2021 / 04:09 GMT
Best Black Friday 2018 PS4 and PS4 games deals
UPDATED: Snap up some fantastic deals on PS4 bundles!
The miniaturised PlayStation Classic will arrive in time for Christmas
Featuring 20 pre-loaded games
30 October 2018 / 11:36 GMT 5 November 2021 / 06:11 GMT
Sony's bringing PlayStation games to iOS and Android
The best characters from Sony's history on your mobile? Yes please
24 March 2016 / 14:57 GMT 16 November 2021 / 17:54 GMT
Extremely rare Super Nintendo PlayStation prototype discovered in the wild
We're looking at an amazing relic here – now, will the guy actually plug it in?
3 July 2015 / 21:44 BST 16 November 2021 / 17:30 GMT
Sony at E3 2015: Uncharted 4, Final Fantasy VII remake (yes, really!) and more
Hold on to your hats, fellow gamers. You're in for a treat
16 June 2015 / 03:36 BST 16 November 2021 / 17:28 GMT
Fully Charged: Elon Musk building Hyperloop test track, Microsoft's latest Lumias are super cheap, and The Simpsons invading Minecraft
End the week strong with our morning roundup of tech news tidbits


The houses blend seamlessly with the tranquil landscape, surrounded by shady gardens and facing a sea of emerald padi. Each patio faces the sunset. There is no traffic noise here and the air is pure and sweet.
Behind the houses, groves of mature bamboo separate the project from the village. It's hard to believe this is all happening 5 minutes from Ubud.


NJOP hosted a webinar entitled teaching NJOP's Hebrew Reading Crash Courses, which was presented on August 11th, 2011 by NJOP's famed Hebrew Teaching Specialist, Florence Wiener. In the webinar Florence shared "best practices" on how to successfully teach NJOP's four Hebrew programs. The four programs include the Hebrew Reading Crash Course Level I, Level II, One Day Review and Hebrew Writing Crash Course. We have archived the presentation here for you to download and view at your convenience. The webinar will be helpful to both instructors who have taught the classes before and to those who are teaching it for the first time. Florence offers helpful hints for making successful presentations and for making good presentations even better with step-by-step instructions that will enable viewers to learn how to best utilize all of NJOP's materials and how its unique methodology helps students learn to read Hebrew and retain what they've learned. If you are planning to run one or more of our Hebrew courses in your community, we highly recommend you view this presentation!
You can download a recording of the event here.


text:
namespace base {
class FilePath;
}  // namespace base

namespace extensions {
class EventRouter;
}  // namespace extensions

namespace ash {
namespace file_system_provider {
namespace operations {

// Creates a file. If the file already exists, then the operation will fail with
// the FILE_ERROR_EXISTS error. Created per request.
class CreateFile : public Operation {
 public:
  CreateFile(extensions::EventRouter* event_router,
             const ProvidedFileSystemInfo& file_system_info,
             const base::FilePath& file_path,
             storage::AsyncFileUtil::StatusCallback callback);

  CreateFile(const CreateFile&) = delete;
  CreateFile& operator=(const CreateFile&) = delete;

  ~CreateFile() override;

  // Operation overrides.
  bool Execute(int request_id) override;
  void OnSuccess(int request_id,
                 std::unique_ptr<RequestValue> result,
                 bool has_more) override;
  void OnError(int request_id,
               std::unique_ptr<RequestValue> result,
               base::File::Error error) override;

 private:
  base::FilePath file_path_;
  storage::AsyncFileUtil::StatusCallback callback_;
};

}  // namespace operations
}  // namespace file_system_provider
}  // namespace ash

#endif  // CHROME_BROWSER_ASH_FILE_SYSTEM_PROVIDER_OPERATIONS_CREATE_FILE_H_

redpajama_set_name: RedPajamaGithub


The Cover Story Upholstery Canningvale offer all aspects of re-upholstery services to Fremantle and all surrounding areas.
Looking to have your sofa reupholstered or your favourite TV chair we can help. Cover Story Canningvale offer a premium upholstery service with our team of time served craftsmen and craftswomen who have the expert knowledge to put the love back into your favourite piece of furniture and bring back to it's former glory.
Our aim is to offer the best upholstery service in Canningvale and all surrounding areas. Whether you are looking to have a family favourite couch reupholstered or to have your outdoor cushions replaced we offer a premium custom made product.
What makes Cover Story Canningvale different? Cushion covers is one product that makes us different to many of our competitors we offer a free collection of your existing cushions so we can ensure a bespoke fit with your new replacement cushions, we can also offer to have your cushions Dacron™ wrapped which will give more life to your existing cushions. We also offer high density seat foam replacement.
So looking for the best upholsterer in Canningvale give us a call for free no obligation quote. Best Upholstery Canningvale.
Dining chair re-upholstery / repairs Canningvale.


text:
Q: Pass JSON string form one app to another app (Windows 8.1 Apps) C# I'm using custom protocol to open another app from windows runtime app. I am using following code snippet:
await Launcher.LaunchUriAsync(new Uri("appb://hello"));
It works fine when there is plain string. But It gives parse error while passing a JSON string.
Invalid URI: The hostname could not be parsed.
I'm creating JSON by:
 JObject jObj = new JObject();
 jObj.Add("Name", "abcdef");
 jObj.Add("Address", "acvdfs");
 string json = jObj.ToString();

It gives JSON as:

{   "Name": "abcdef",   "Address": "acvdfs" }

A: Your issue is because you're sending the entire json string to be created as a Uri.
You will need to get the required values out of the string first, and then pass those to your method.
As an example, let's say your
JObject jObj = new JObject();
jObj.Add("Name", "abcdef");
jObj.Add("Address", "acvdfs");
string json = jObj.ToString();

code will give you a "{Name}/{Address}" output - appb://abcdef/acvdfs
Instead of parsing that directly to a string, you will need to get the values out first.
Otherwise your

{ "Name": "abcdef", "Address": "acvdfs" }

is what is causing the

Invalid URI: The hostname could not be parsed.

error.
You could do this in order to retrieve the values from that string:
var values = jObj.Properties().Select(x => x.Value.ToString()).ToArray(); // Gives you an array of the values.

var path = string.Join("/", values); // Creates an "a/b" path by joining the array.

await Launcher.LaunchUriAsync(new Uri("appb://" + path)); // Give that path to create the Uri and pass to your method.

This code assumes you're only using the keys to create the path the way I have. It will work for any number of keys, as it just joins all the values together with "/" - e.g. a/b/c/d/e/f/g etc.
Any questions, just ask :)
Hope this helps!

redpajama_set_name: RedPajamaStackExchange


Below you'll find physical locations (alphabetically) where select Lovebee products are sold! We recommend calling ahead to make sure the item(s) you'd like are in stock. If you'd like to stock Lovebee products at your location please contact us.
The Ridgeway Wellness Centre is home to a talented team of health care practitioners who have been serving the Niagara region with top-tier holistic therapies since 2007.
Unique Creations Artisan's Outlet carries hand-crafted merchandise from over 100 primarily Canadian artisans! Their bricks and mortar store opened in 2011 and is located in the downtown core of Ridgeway.


The guided elmass® broaching tools simplify broaching of internal keyways and splines.
The self centering tools are simple to assemble and within ready for production on any of your machines that makes a linear movement.
The elmass® broaching tools were originally designed to broach internal keyways in through bores. However it did not take long until further applications were discovedred.
By matching the guide bush and the shape of the cutter almost any internal shape can be broached.
Tools of any shape or tolerance can be made to your requirements within a few days.


Your words make my mouth water!!!!
O.k all you people who love to cook and those of us who just love to eat their cooking you guys are in for a treat. Carolyn Wright is the real deal. Good food is to Carolyn what clothes shopping is to me and Lord you know I love that!! Mix Carolyn's sense of humor with all things food and it promises to be an interesting ride, one I can't wait to take. I was at Cochon's on Saturday night and she just nailed the experience. Look forward to more!
That made me hungry, good job!
might be interested in your thoughts in a food critic section for Village News – only 4 times/year, but it could be interesting!!!
Wow you really made me hungry this morning. I am going to Cochon on Wednesday night and now I know what I am ordering. You go girl!!


Embalmer - What is an Embalmer?
An embalmer is someone who prepares bodies to be displayed at funerals or to be studied for medical research. Embalmers use embalming fluid, formaldehyde and embalming makeup to preserve cadavers and make bodies appear as they did when the person was alive.
Embalmers can also be morticians and usually work at funeral homes prepare bodies for funerals. Many times they perform their work on short notice and tight deadlines. Usually bodies are prepared within 24 to 36 hours of death, so embalmers must act quickly to prepare a body for a funeral. Funeral directors help people plan funerals, which have dates and times carefully planned for family members and friends and you will need to prepare the body in time for the funeral.
Embalming dates back to ancient Egyptian times. The art of the craft is similar, but modern technology and advances have changed the job considerably. Today's embalmers work in funeral homes and work with funeral directors.
If you decide to work in a funeral home, you will get to help people on a daily basis. People mourning the loss of a loved one are often looking for ways to remember and memorialize the person, and your job as an embalmer can help them do that.
Some embalmers work in medical centers to prepare bodies for research. Cadavers are often transported long distances, so they must be preserved for longer periods of time. Embalmers with this career learn how to preserve bodies in a slightly different way, but their work is very similar to embalmers at funeral homes.
Cadavers are used in medical schools and at research centers. Students who are learning to become doctors study bodies to learn about human anatomy and medical researchers study bodies to learn more about how organs work and the effects of diseases.
Working as an embalmer in the medical field is a very interesting and important career. If it weren't for carefully prepared cadavers, many medical students wouldn't have the chance to receive hands-on training that can help them be the best doctors possible. Embalmers also indirectly help advance the medical science field when the cadavers they prepare help researches find answers to important questions and even make new discoveries.
On average, embalmers earn an annual salary of $37,000. If you work as an embalmer full time, you will likely qualify for benefits like health, dental and vision insurance.
If you work in a funeral home, your salary will probably be between $17,000 and $50,000 a year. If you work at another type of company as an embalmer, you may earn between $28,000 and $51,000 a year. Or, if you work at a private practice or firm, you will most likely earn $23,000 to $39,000 a year.
If you find a job at an organization that has one to nine employees you will probably earn between $24,000 and $42,000 a year.
To start a career as an embalmer, you will need to earn a degree in mortuary science. Embalmers earn either an associate's degree or a bachelor's degree, both of which will prepare you well for this career.
An associate's degree usually takes about two years to earn while a bachelor's degree takes about four years to earn. Both programs are very similar, but if you earn your bachelor's degree you may be more attractive to employers. In general, employers look for applicants who have high levels of training, so earning a bachelor's degree can help you be more competitive in the job market.
A mortuary science degree program will teach you about the biological and chemical processes involved in decay and preservation. You'll also learn all about human anatomy and embalming practices like using chemicals and makeup.
When you enroll in a mortuary science school you will also learn about how a funeral home operates and what your role in the organization will be. You'll learn how to work with clients to help them remember their loved ones.
Embalmers are required to be licensed by the state they live and work in. Since each state has different requirements you will need to contact your city or state offices to find out how to obtain a license.
Working as an embalmer is an interesting and rewarding career. With this job you will get to help people through the grieving process and help them find ways to remember their loved ones. Embalmers get to work in a field that combines science and art, so you will have a unique opportunity to develop and use very precise skills.
If you want to pursue a career as an embalmer the best way to start is to enroll in a mortuary science degree program. After you have earned your degree and obtained a license you will be prepared to work as an embalmer in a funeral home or at a medical center.


Phrase Just call him butter cuz he's on a roll.
When a player is on fire or makes a good play.
When MJ's game starts rolling this year.
When Kobe takes your skill and rolls in around you before you can say time out.
When a player gets in a groove and starts makin' shots many times in a row.
Maybe it's cause Kobe is just butter.
Any basketball player on an offensive streak.


Recently, Allpar road-tested the Jeep Wrangler Sahara, finding a mixture of old and new inside.
Older items included the hard-drive stereo, complete with a tilting screen to show a DVD reader; the basic design, one of the oldest in the FCA empire; and much of the underlying hardware.
Newer items included welcome revisions to the stereo, including better USB thumb drive handling, and top-removal and window-lowering tools in the glovebox (which was not quite large enough for the owner's manual, oddly enough).
The 2015 model year ushered in a standard eight-speaker stereo with a new sound bar; the optional Alpine Audio Package had nine Alpine speakers with a new all-weather subwoofer under the cargo floor), while the 2016 Saharas will have an olive green interior option, body color bumper, and different wheels.
The 2014s had minor and mostly cosmetic changes, other than the launch of a Rubicon X and Freedom III. The five-speed automatic replaced an older four-speed in 2012, as the old 3.8 "minivan engine" was swapped out for a new Pentastar V6. There were also some aerodynamic improvements and off-road upgrades for the Rubicon. The interior had been redesigned in 2011.
A "completely new" Wrangler is due in 2018 or so, but it will most likely keep the basic body-on-frame, solid-axle setup of the current Jeep icon.
The next-generation Jeep Wrangler won't be all aluminum, according to FCA CEO Sergio Marchionne.
Marchionne spoke to reporters at the SAE Foundation's Annual Celebration last night. He was the guest of honor at the event where he received the group's 2015 Industry Leadership award.
According to a report in today's Detroit News, Marchionne said that company tests showed the costs of an all-aluminum body outweighed the weight-saving benefits.
"Because of the difference in cost, not just the new material but the actual assembly process, I think we can do almost as well without doing it all-aluminum," Marchionne was quoted as saying.
The decision could have been fueled by the difficulties Ford Motor Company faced in producing the latest-generation F-150 pickup. The problems, including the tearing of aluminum body panels in the stamping process, caused delays and constrained early deliveries of Ford's moneymaker.
The announcement could boost the prospects for Toledo, Ohio, which is spending millions of dollars trying to keep Wrangler production in the city.
Marchionne didn't give any hints, but said Toledo is one of just two sites being considered for the next-generation of the Wrangler.
During his comments, Marchionne also spoke about the National Highway Traffic Safety Administration's (NHTSA) latest actions.
He said the agency's increasingly aggressive stance will increase automakers' costs as they try to meet new demands; and that he will not be testifying at the NHTSA's public hearings scheduled for July 2.
Speaking about the new Jeep Renegade, Marchionne confirmed that several issues, including some software problems, were limiting availability of the Italian-built small Jeep.
Jeep's off-road enthusiast focused Wrangler SUV will be significantly more fuel efficient for the 2018 model year.
The iconic utility vehicle is slated to be fitted with an eight-speed automatic transmission that will ease its fuel consumption. Chrysler currently uses the same transmission in the Ram 1500 pickup truck, the Dodge Durango SUV and the Jeep Grand Cherokee SUV. Jeep hasn't officially announced the change, but a filing with the SEC originally reported by Automotive News is tipping the brand's plans.
According to the filing, Jeep expects the Wrangler to return nine percent better fuel economy when equipped with the eight-speed than it currently does with a five-speed automatic. Currently the five-speed automatic Wrangler is rated to return 17 MPG in city driving and 21 MPG on the highway.
The Wrangler is slated to be re-designed for 2018 with an aluminum body that will also enhance fuel economy. Chrysler needs to improve average fuel economy across the Jeep line and a smaller displacement engine than the current 3.6-liter V6 will be necessary to do so in the Wrangler, FCA CEO Sergio Marchionne has said.
Other efficiency-minded changes are afoot at Chrysler. The company plans to produce its next-generation plug-in hybrid Town & Country minivan at its Windsor, Canada assembly plant.