text:
Finding driver pathways in cancer: Models and algorithms
Fabio Vandin, Eli Upfal, Benjamin J. Raphael
Background: Cancer sequencing projects are now measuring somatic mutations in large numbers of cancer genomes. A key challenge in interpreting these data is to distinguish driver mutations, mutations important for cancer development, from passenger mutations that have accumulated in somatic cells but without functional consequences. A common approach to identify genes harboring driver mutations is a single gene test that identifies individual genes that are recurrently mutated in a significant number of cancer genomes. However, the power of this test is reduced by: (1) the necessity of estimating the background mutation rate (BMR) for each gene; (2) the mutational heterogeneity in most cancers meaning that groups of genes (e.g. pathways), rather than single genes, are the primary target of mutations. Results: We investigate the problem of discovering driver pathways, groups of genes containing driver mutations, directly from cancer mutation data and without prior knowledge of pathways or other interactions between genes. We introduce two generative models of somatic mutations in cancer and study the algorithmic complexity of discovering driver pathways in both models. We show that a single gene test for driver genes is highly sensitive to the estimate of the BMR. In contrast, we show that an algorithmic approach that maximizes a straightforward measure of the mutational properties of a driver pathway successfully discovers these groups of genes without an estimate of the BMR. Moreover, this approach is also successful in the case when the observed frequencies of passenger and driver mutations are indistinguishable, a situation where single gene tests fail. Conclusions: Accurate estimation of the BMR is a challenging task. Thus, methods that do not require an estimate of the BMR, such as the ones we provide here, can give increased power for the discovery of driver genes.
Algorithms for Molecular Biology
https://doi.org/10.1186/1748-7188-7-23
Published - Sep 6 2012
Background mutation rate
Driver mutations
Somatic Mutations
Dive into the research topics of 'Finding driver pathways in cancer: Models and algorithms'. Together they form a unique fingerprint.
Driver Mathematics 100%
Pathway Mathematics 91%
Cancer Mathematics 78%
Mutation Mathematics 76%
Mutation Rate Medicine & Life Sciences 33%
Background Mathematics 26%
Vandin, F., Upfal, E., & Raphael, B. J. (2012). Finding driver pathways in cancer: Models and algorithms. Algorithms for Molecular Biology, 7(1), [23]. https://doi.org/10.1186/1748-7188-7-23
Vandin, Fabio ; Upfal, Eli ; Raphael, Benjamin J. / Finding driver pathways in cancer : Models and algorithms. In: Algorithms for Molecular Biology. 2012 ; Vol. 7, No. 1.
@article{43be871e08194331a303792a39ee844c,
title = "Finding driver pathways in cancer: Models and algorithms",
abstract = "Background: Cancer sequencing projects are now measuring somatic mutations in large numbers of cancer genomes. A key challenge in interpreting these data is to distinguish driver mutations, mutations important for cancer development, from passenger mutations that have accumulated in somatic cells but without functional consequences. A common approach to identify genes harboring driver mutations is a single gene test that identifies individual genes that are recurrently mutated in a significant number of cancer genomes. However, the power of this test is reduced by: (1) the necessity of estimating the background mutation rate (BMR) for each gene; (2) the mutational heterogeneity in most cancers meaning that groups of genes (e.g. pathways), rather than single genes, are the primary target of mutations. Results: We investigate the problem of discovering driver pathways, groups of genes containing driver mutations, directly from cancer mutation data and without prior knowledge of pathways or other interactions between genes. We introduce two generative models of somatic mutations in cancer and study the algorithmic complexity of discovering driver pathways in both models. We show that a single gene test for driver genes is highly sensitive to the estimate of the BMR. In contrast, we show that an algorithmic approach that maximizes a straightforward measure of the mutational properties of a driver pathway successfully discovers these groups of genes without an estimate of the BMR. Moreover, this approach is also successful in the case when the observed frequencies of passenger and driver mutations are indistinguishable, a situation where single gene tests fail. Conclusions: Accurate estimation of the BMR is a challenging task. Thus, methods that do not require an estimate of the BMR, such as the ones we provide here, can give increased power for the discovery of driver genes.",
keywords = "Background mutation rate, Cancer, Driver mutations, Generative models, Pathways, Somatic Mutations",
author = "Fabio Vandin and Eli Upfal and Raphael, {Benjamin J.}",
note = "Funding Information: We thank the anonymous reviewers for helpful suggestions that improved the manuscript. A preliminary version of this work was presented at WABI 2011. This work is supported by NSF grants IIS-1016648 and CCF-1023160, the Alfred P. Sloan Foundation, and in part by the MIUR of Italy under project AlgoDEEP port. 2008TFBWL4. BJR is also supported by an NSF CAREER Award (CCF-1053753) and a Career Award at the Scientific Interface from the Burroughs Wellcome Fund. The results published here are in whole or part based upon data generated by The Cancer Genome Atlas pilot project established by the NCI and NHGRI. Information about TCGA and the investigators and institutions who constitute the TCGA research network can be found at http://cancergenome.nih.gov/.",
doi = "10.1186/1748-7188-7-23",
journal = "Algorithms for Molecular Biology",
publisher = "BioMed Central",
Vandin, F, Upfal, E & Raphael, BJ 2012, 'Finding driver pathways in cancer: Models and algorithms', Algorithms for Molecular Biology, vol. 7, no. 1, 23. https://doi.org/10.1186/1748-7188-7-23
Finding driver pathways in cancer : Models and algorithms. / Vandin, Fabio; Upfal, Eli; Raphael, Benjamin J.
In: Algorithms for Molecular Biology, Vol. 7, No. 1, 23, 06.09.2012.
T1 - Finding driver pathways in cancer
T2 - Models and algorithms
AU - Vandin, Fabio
AU - Upfal, Eli
AU - Raphael, Benjamin J.
N1 - Funding Information: We thank the anonymous reviewers for helpful suggestions that improved the manuscript. A preliminary version of this work was presented at WABI 2011. This work is supported by NSF grants IIS-1016648 and CCF-1023160, the Alfred P. Sloan Foundation, and in part by the MIUR of Italy under project AlgoDEEP port. 2008TFBWL4. BJR is also supported by an NSF CAREER Award (CCF-1053753) and a Career Award at the Scientific Interface from the Burroughs Wellcome Fund. The results published here are in whole or part based upon data generated by The Cancer Genome Atlas pilot project established by the NCI and NHGRI. Information about TCGA and the investigators and institutions who constitute the TCGA research network can be found at http://cancergenome.nih.gov/.
N2 - Background: Cancer sequencing projects are now measuring somatic mutations in large numbers of cancer genomes. A key challenge in interpreting these data is to distinguish driver mutations, mutations important for cancer development, from passenger mutations that have accumulated in somatic cells but without functional consequences. A common approach to identify genes harboring driver mutations is a single gene test that identifies individual genes that are recurrently mutated in a significant number of cancer genomes. However, the power of this test is reduced by: (1) the necessity of estimating the background mutation rate (BMR) for each gene; (2) the mutational heterogeneity in most cancers meaning that groups of genes (e.g. pathways), rather than single genes, are the primary target of mutations. Results: We investigate the problem of discovering driver pathways, groups of genes containing driver mutations, directly from cancer mutation data and without prior knowledge of pathways or other interactions between genes. We introduce two generative models of somatic mutations in cancer and study the algorithmic complexity of discovering driver pathways in both models. We show that a single gene test for driver genes is highly sensitive to the estimate of the BMR. In contrast, we show that an algorithmic approach that maximizes a straightforward measure of the mutational properties of a driver pathway successfully discovers these groups of genes without an estimate of the BMR. Moreover, this approach is also successful in the case when the observed frequencies of passenger and driver mutations are indistinguishable, a situation where single gene tests fail. Conclusions: Accurate estimation of the BMR is a challenging task. Thus, methods that do not require an estimate of the BMR, such as the ones we provide here, can give increased power for the discovery of driver genes.
AB - Background: Cancer sequencing projects are now measuring somatic mutations in large numbers of cancer genomes. A key challenge in interpreting these data is to distinguish driver mutations, mutations important for cancer development, from passenger mutations that have accumulated in somatic cells but without functional consequences. A common approach to identify genes harboring driver mutations is a single gene test that identifies individual genes that are recurrently mutated in a significant number of cancer genomes. However, the power of this test is reduced by: (1) the necessity of estimating the background mutation rate (BMR) for each gene; (2) the mutational heterogeneity in most cancers meaning that groups of genes (e.g. pathways), rather than single genes, are the primary target of mutations. Results: We investigate the problem of discovering driver pathways, groups of genes containing driver mutations, directly from cancer mutation data and without prior knowledge of pathways or other interactions between genes. We introduce two generative models of somatic mutations in cancer and study the algorithmic complexity of discovering driver pathways in both models. We show that a single gene test for driver genes is highly sensitive to the estimate of the BMR. In contrast, we show that an algorithmic approach that maximizes a straightforward measure of the mutational properties of a driver pathway successfully discovers these groups of genes without an estimate of the BMR. Moreover, this approach is also successful in the case when the observed frequencies of passenger and driver mutations are indistinguishable, a situation where single gene tests fail. Conclusions: Accurate estimation of the BMR is a challenging task. Thus, methods that do not require an estimate of the BMR, such as the ones we provide here, can give increased power for the discovery of driver genes.
KW - Background mutation rate
KW - Cancer
KW - Driver mutations
KW - Generative models
KW - Pathways
KW - Somatic Mutations
U2 - 10.1186/1748-7188-7-23
DO - 10.1186/1748-7188-7-23
JO - Algorithms for Molecular Biology
JF - Algorithms for Molecular Biology
Vandin F, Upfal E, Raphael BJ. Finding driver pathways in cancer: Models and algorithms. Algorithms for Molecular Biology. 2012 Sep 6;7(1):23. doi: 10.1186/1748-7188-7-23


The Republican Party snagged me in asking for support ($$$) for John McCain's upcoming Presidential run. Although I side-stepped the campaign donation, I did say that I would encourage others to learn more about him. To start with, I'm including a "timeline" history of John McCain below. He and his fatherand his grandfather, served the United States honorably … and from where I stand, that's a good starting point for a Presidential candidate.


text:
Q: Reproducing Kernel of a RKHS of continuous functions may not be continuous in two variables together Let $\mathcal{K}$ be a Hilbert Space of continuous functions on some topological space, where point evaluations are continuous linear functional on $\mathcal{K}$.
That is $\mathcal{K}$ is RKHS, suppose the  kernel is $K(x,y)$,  since $K(x,\cdot) \in \mathcal{K} $, $K$ is continuous seperately in $x$ and $y$. But it need not be continuous in two variable.
Please someone give me an example that Reproducing kernel need not be continuous in two variables.

A: Let $1=a_0=a_1>\ldots >a_n>\ldots >0$, and let $e_n$ be the "triangle" function that vanishes outside $(a_{n+1},a_{n-1})$, equals $1$ at $a_n$, and interpolates linearly from $0$ to $1$ on $[a_{n+1},a_n]$ and from $1$ to $0$ on $[a_n,a_{n-1}]$.
Put $K(x,y)=\sum_1^\infty e_n(x)e_n(y)$. This is well defined, vanishes for $x=0$ (or $y=0$), is separately continuous on $[0,1]\times [0,1]$, is positive definite, and $K(x,x)$ oscillates between $1$ (at $a_n$) and $1/2$ (at $(a_{n+1}+a_n)/2)$ as $x\to 0$ (where $K(0,0)=0$).
The associated RKHS is the set of piecewise affine continuous functions $\sum_1^\infty c_ne_n$ with $\sum c_n^2<\infty$. The unit ball is not equicontinuous on $[0,1]$, i.e. it is not compact in $C([0,1])$, a necessary and sufficient condition for the continuity of $K$ on $[0,1]\times [0,1]$.

redpajama_set_name: RedPajamaStackExchange


text:
Accidental Critic: Bel Canto, an Escape into Opera
Chicago's Lyric Opera House
I don't even remember how it started. Well, yes I do; it started when I picked up Ann Patchett's book Bel Canto in a bookstore. I bought it, read it straight through, then started right back at page 1 and did it all over again. That was not long after the book was published in 2001. I've re-read it every year or two since then.
What I don't remember is when or how I learned that Bel Canto was being made into an opera—and by the Lyric Opera of Chicago, which is my local company. But I knew immediately that I needed to see it.
That's where this journey began. I'd never seen an opera, but always wanted to. I have friends who love opera and friends who hate it; I figured I had a slightly better than 50-50 chance of enjoying it myself. The making of Bel Canto the opera meant the stars had aligned for me. I was going.
Oct. 29: Friend Jack tells me the Lyric is staging three free public events in conjunction with the opera's premiere—and one is a discussion with Ann Patchett and Renée Fleming. Wow. Just wow! I've snagged tickets to the discussion, and also a chamber music concert featuring music curated by Jimmy Lopez, composer of the opera.
Nov. 5: I've started re-reading Bel Canto—yes, again—in anticipation of seeing the opera. It's been long enough since I read it—and I've read it so many times already—that I wonder if it will still have the same magic for me. My guess is yes, but who's to say? Is there some point at which you've just read any book often enough, and there's nothing left for it to give or you to receive? I've never had this kind of long-term love affair with any other book, so I really don't have a basis for knowing the answer. Can you believe I actually had to buy a new copy, though? I looked all over, for days and days, but couldn't find mine anywhere. Murphy's Law suggests it will turn up, now that I've re-purchased, but my guess is that I loaned it to someone who never got it back to me. But given the amount of pleasure I've taken from this book over the years, buying a second copy seems right–a small thank you to Ann Patchett for what she's given me.
Nov. 8: Chamber concert was…interesting. Six pieces on the program: three by composers that influenced Jimmy Lopez, interspersed with three pieces by Lopez. I really enjoyed the first, kind of enjoyed the second; third was Stravinsky, which has never been my cuppa; and the rest were…interesting. Not bad, just not what my untrained ear and mind think of when I think of the word music. By the end, the concert felt to me like a conceptual exploration of instrumental sound. Atonal, sometimes cacophonous. But as a preparation for seeing the opera, definitely interesting, definitely worthwhile. I'm really intrigued to see what Lopez does with the musical score for the opera. There are parts of the story that seem perfectly suited to this type of music, and others where I can't imagine it working. Even my husband—no big fan of opera—says he really wants to see the opera now, to hear what Lopez does with the score. An interesting note: The first piece on the program today fascinated both my husband and me because had we not seen it performed in person, we would each have assumed that there was more than one instrument playing, which in fact it was a solo performer playing two, somehow competing, musical lines on the same instrument at the same time. I was mesmerized. So this was an eye-opening, educational day for me.
Lyric Opera House Chicago – Inside the Ardis Krainik Theatre
Nov. 18: Heaven! Ann Patchett in person, and on top of that my first glimpse of Renée Fleming, at a discussion featuring just the two of them on topics ranging from Bel Canto the book, to Bel Canto the opera, to the creative process, and the life of a diva versus the writing life. They turn out to be very good friends, who had never met before Patchett wrote Bel Canto. I thought that Fleming, as creative consultant for the opera, would be interviewing Patchett at this event. But to the extent that there was interviewing being done, it was mostly Patchett interviewing Fleming. I guess I should have expected that; Fleming is the opera diva after all, and Patchett the writer.
It was absolutely fascinating to hear Patchett talk about her writing process generally, but especially her writing of Bel Canto. She confirmed the book was based on the 1996 terrorist take-over of the Japanese embassy in Lima, Peru, and said she realized as the hostage crisis dragged on that she wanted to write about it. "I was following it on the news, and I thought, "This is a Patchett novel,' " she said. Brilliant. She said she was devastated when the crisis ended with the terrorists being killed…because those were her characters, and she knew that they would have to die in her story as well. She chose an opera singer as her main character, even though she'd never had any interest in opera, because she wanted to explore the question: "What if there's not a common language? How do you tell a story without a common language?"
I took pages and pages of notes–just a million quotable moments on topics ranging from the book and the writing process, to development of the opera, the differences—and friendship—between Patchett and Fleming, and on and on. I'm going to re-read my notes and hope the live-stream of the discussion gets posted to YouTube by the Lyric so I can watch/listen again.
I finished re-reading the book before this event, and I have to say that it continues to surprise and amaze me. There are many things I had forgotten, and some that I'm not even sure I ever noticed before. (Having bought a new copy, there were no notes in the margins, no sticky notes next to passages that had stood out for me in the past.) I remembered the comedy of the scene in which the Russian, Victor Fyodorov, declares his love for Roxane. But I didn't remember its profound messages about the nature of love, the uniting gift of music and art, or the cultural differences that art can bridge; did I ever notice those before? Victor declares his love and tells Roxane simply that "it is a gift" to her. That she has no love to return to him…doesn't bother him at all. What if she said she loved him in return? He says:
"A beautiful thought, surely, but my wife would not be pleased. When you think of love you think as an American. You must think like a Russian. It is a more expansive view."
And with that, the joke is not on him, but on her.
That's just one example. This book just gives and gives and gives to me. I think perhaps I could re-read it every other year for the rest of my life, and never be disappointed.
Nov. 22: I have tickets! Six of us will go together to a mid-week performance, Tuesday Jan. 5. I'm excited beyond words. I wanted to get weekend tickets, to avoid being out so late on a work night, but scheduling with friends made that difficult. Alas. Our seats are on the main floor in the center, some distance back from the stage, but not in the very back. Good seats, from which I think I'll be able to make an informed decision about whether opera is really for me. Opera! Bel Canto! Hooray!
Dec. 3: I've made a decision that I might regret. Having heard wonderful reviews of Renée Fleming in The Merry Widow, and not wanting to miss a chance to see her perform, I've bought tickets for The Merry Widow. That means Bel Canto will not be my first opera, because The Merry Widow closes in December. This makes me somewhat sad, and I really struggled with the decision. It does seem that Bel Canto should be my first; but balanced against the chance to see Renée Fleming, I've opted for Fleming. I must admit to being influenced by a Cyber Monday offer (valid all week) offering a great discount for any three-performance series, so I also bought tickets for Der Rosenkavalier (February) and Romeo and Juliet (March). I think I can safely expect to know by the end of March whether I like opera.
Dec. 5: A new quandary. I just learned that the world premiere performance of Bel Canto will be broadcast live on WFMT-FM. Should I listen in? I would love to experience the opening-night performance; but would it be better to wait for the full sensory experience in person? Fleming said during the Nov. 18 discussion that the human voice in opera is very different in person than on even the best recording; you just don't hear the voice the same way. Add to that the extravaganza of costumes and scenery, and I'm afraid simply listening to the music will be a poor second-best. Especially for my first opera experience, would that be a mistake?
Dec. 7: Here's my answer: I listened to the world premiere broadcast on radio, and I'm glad I did. For one thing, it was exciting and fun, and I'm not too proud to admit it. I was part of a very small cohort listening and tweeting about the performance, so I "met" a couple of people in cyberspace and wasn't alone. (My husband listened as well, so I truly wasn't alone at home, either.) Also, the good folks at the Lyric clearly have been building excitement via Twitter and other social media; so joining the Twitter conversation gave me a glimpse of the costumes and sets. They look gorgeous. And having now heard the music, I don't think that doing so will diminish anything about the live performance.
That said, I don't think listening in can substitute for live performance. Aside from the sound quality, it's harder to concentrate without the multi-sensory immersion—with the lights on and nowhere to focus your eyes other than the supertitles shown on a computer screen. But listening in has only increased my enthusiasm to see this show. The music didn't seem inaccessible to me—and I have worried that it might, given the nature of the chamber concert curated by Jimmy Lopez. It doesn't seem easy, necessarily, but also not atonal nor impossibly conceptual. I feel plebeian saying this, but I was afraid of a purely conceptual exploration; I don't think it is that. Plus, there's a Gregorian chant somewhere in Act 2, and I love Gregorian chants.
Here's a sneak preview, courtesy of Twitter:
Danielle de Niese as Roxane:
"You were destined to come here…" pic.twitter.com/ESEY6pYgFb
— Lyric Opera Chicago (@LyricOpera) December 8, 2015
The set in Act 2:
A fog, La garúa, has settled on the mansion. More than 25 days have passed. #LyricBelCanto pic.twitter.com/U8kLU41a5w — Lyric Opera Chicago (@LyricOpera) December 8, 2015
Cesar's solo:
"I sang to forget who I was, where I was & what I didn't dare to dream." (Cesar) #LyricBelCanto pic.twitter.com/ISilmEktUZ
Dec. 13: I have seen my first opera! Here's what I'm thinking after attending The Merry Widow:
Acting, sets, costumes, voices—none of it fell short of expectations. This was every bit the spectacle I thought it would be. Unfortunately, I somehow missed out on the information that Renée Fleming was leaving the cast mid-way through the run, so I still haven't seen her perform. I'm disappointed by that, but not because of Fleming's replacement in the lead role of Hanna, Nicole Cabell, who was superb. I hope I'll have another opportunity to see the legendary Fleming perform; I already know that I like opera well enough to want that.
I enjoyed myself, but does that mean I like opera? I'm not sure. First, The Merry Widow is an operetta—which kind of makes me want to say "barely an opera." The players were mostly opera singers, but the music and theme very light and fun, and there's a good deal of spoken language (rather than sung); plus, of course, The Merry Widow is in English. So how will I react to something in a different language or something very, very dark or serious? Will it become difficult? Or will I perhaps love it even more? Nothing to do but wait and see.
I'm glad my first opera wasn't Bel Canto because this experience taught me something important: Even if the lyrics are in my native language, I will not understand them when sung in operatic voice, and I therefore need to be well acquainted with the story and the libretto in advance. Otherwise, I risk having my focus distracted by reading the supertitles, and I might miss the performance on stage. Despite The Merry Widow being in English, I spent too much time looking at the titles. Fortunately, I know the Bel Canto story backward and forward, so there's less risk there. But I will try to get hold of the libretto, or at least the libretto notes, to read in advance of the performance. Looking further ahead, this will be even more important when I see Der Rosenkavalier, which I really don't know at all.
Jan. 4: I see Bel Canto tomorrow night, and I think I'm ready. I've read all of the material the Lyric has posted about the opera on its website, including the libretto notes. Having already re-read the book and listened to the premiere broadcast, there's not much more I can do to prepare. Is there?
Bel Canto: The stage before curtain time
Jan. 5: Tonight was the night—and I loved it. First off, the sets were amazing. A. Maz. Ing. With the palace as the set throughout the performance, the production uses projection to show the world outside—day changing to night changing to day; the fog that settles over the city and the dazzling sunshine that coaxes terrorists and hostages outside when the fog lifts; flashing lights from emergency vehicles. It was both gorgeous and effective. In the second act, two new set structures move out onto the stage: Roxane's bedroom, cantilevered out from above as the second floor on one side of the stage; a kitchen cupboard at floor level on the other, catty-corner from the bedroom. In these two locations, the simultaneous love stories of Roxane/Hosokawa and Gen/Carmen unfold as the audience watches both. And hears both, as singers in the two opposite areas of the set sing into and over each other, not quite intertwining but not competing, either. This was a hallmark of the music throughout the performance—multiple voices singing, not in harmony, but rather seeming to perform different songs simultaneously. Although difficult to separate and isolate sometimes, it was a moving way to show the competing interests and viewpoints of the characters, and also to collapse the amount of time needed to tell this complicated story; rather than characters telling their own stories in isolation, they told their stories simultaneously—as if talking over each other in the chaos created by events on stage.
All of that worked for me amazing well, but I don't know if it would work as well for someone who didn't already know this story. In fact, a couple of the friends I attended with seemed a bit overwhelmed by the experience, though they have far more experience with classical music and opera than I. One said during intermission, "That's a really crowded stage!"—and it was, though I really hadn't noticed. Throughout most of the production, the stage is crowded with both terrorists and hostages; rarely do one or two people stand alone on it, or sing alone. Having precious little experience with which to compare it, I nonetheless suspect that it wasn't just the stage that was crowded, but also the music itself. Lopez's score packs in a lot of musical lines—melodies?—layering on top of each other and mixing together, but not really harmonizing in a classic sense. It's busy; it's dense. There's as much going on musically as visually.
And did I mention that eight different languages come into play? While much is in English, there's an almost equal amount of Spanish (which, if you know Spanish, is actually easier to understand in operatic voice than the English). Two of our main characters being from Japan, there's a good bit of Japanese as well, plus French, German, Latin, Russian and Quechua. Supertitles projected above the stage translate all of that, of course, so the language itself isn't a barrier for the audience. But it adds another layer to an already multi-layered and very dense production.
Personally, I think it was a perfect adaptation of this book, which is so much about the similarities that unite people from immensely divergent backgrounds. In the book, we grow to love the terrorists and hostages equally, as both we and they discover their kinship. While language separates them, they discover music that brings them together. And yet this discovery of similarities causes additional turmoil sometimes, as the terrorists struggle to retain separation from their hostages as they work toward the political goal that brought them to the palace for a hostage-taking in the first place.
For me, the many layers of music and language combined with a crowded set and somewhat crowded story-telling to bring this book to stage in a compelling way that felt very true to Patchett's book. In fact, Patchett sang the praises of Nilo Cruz's libretto in her November appearance with Fleming, saying, "It should be the Cliff's Notes for the book." Lopez's music seemed the perfect accompaniment to this. Music and libretto combined to pull it all together beautifully.
Would someone less familiar with the book feel the same way? Perhaps not, judging from some of my friends' reactions. Among six of us who attended, at least two were something less than thrilled by the production. So it might be that my personal connection with the book won me over to the opera—or perhaps prepared me, or moved me to prepare myself. It might be that my homework paid off; I know this story inside out, and by attending the Lyric's events leading up to the actual production, I knew enough about Jimmy Lopez's music to have some idea what to expect.
I'm still not certain whether I'm going to turn out to be an opera afficionado. I'll decide after seeing Der Rosenkavalier and Romeo and Juliet whether there's a lot more opera in my future. But I'll do my homework in advance of those. I'll read the libretto or libretto notes and perhaps listen to a recording or the opening-night radio broadcast. That's my lesson moving forward.
My Bel Canto journey won't end here. I expect that I'll continue to read and re-read this book every couple of years, as I have done for more than a decade already, unless and until I eventually find that it has nothing more to give to me. I doubt that will ever happen.
For now, I think Roxane Coss's aria dedicated to Hosokawa at the beginning of the opera sums up my tale perfectly. Given my love affair with this amazing book, once the Lyric Opera decided to commission and stage this work, "I was destined to come here." Here's Danielle de Niese singing "You Were destined to Come Here," from Scene 1 of the opera.
Kim Kishbaugh is no kind of artist at all, but a lover of art in many different forms. She travels through life with an open mind and open eyes in search of magic, and sometimes finds it. She is Escape Into Life's social media editor and a long-time journalist with an unsettling history of seeing the companies she works for go out of business. She blogs occasionally at kkish.net.
Accidental Critic: "I thought I made you up!" (Discussion between Ann Patchett and Renée Fleming)
Lyric Opera of Chicago Broadcasts on WFMT-FM
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redpajama_set_name: RedPajamaCommonCrawl


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Q: My computer doesn't boot up I have a laptop and I formatted it and installed windows 7ultimate 64 bit version. But after started working with it I realized that there is a unallocated space of 275GB is available on my harddisk. So I went to the disk manager and I created a new partition from it.But I remember that the unallocated space was in the type of logical.Now I can't boot up windows.
Please anyone help to fix this.

A: Use bootrec.exe

*

*Set your BIOS to boot to CD

*Use your Windows 7 Disk to boot to

*Press any key when prompted.

*Select time, currency, language, keyboard when prompted

*Select 'Repair Computer'

*In the system recovery options select command prompt

*Type bootrec.exe in the command window
Use the bootrec.exe /fixmbr then bootrec.exe /fixboot options
IF that doesn't work
You can edit your boot.ini file on the root of your hard drive and set the arc path.
This article gives a concise path.  You would edit your partition and detriment one number, more than likely.


text:
Flu institute a booster shot for Wisconsin biotech stature
15 Mar Flu institute a booster shot for Wisconsin biotech stature
Posted at 00:00h in Biotech	by	WTN News 0 Comments
Wisconsin's reputation as a biotechnology leader was greatly enhanced today with the announcement that an Institute for Influenza Viral Research will be established by UW-Madison.
That's the assessment of Mark Bugher, director of University Research Park, where the research institute will be located. Bugher said the institute, which is designed to accelerate the pace of research into the most basic properties of the flu virus, and help prepare for a possible pandemic caused by the avian flu, might have the same impact on the state's image as stem cell research.
Alex Azar II, deputy secretary of the U.S. Department of Health and Human Services, was in Madison for the announcement. Azar said a vaccine exists with some effectiveness against avian flu in humans, but production is slow because the nation has neglected immunization infrastructure. He estimated the U.S. could produce 14 million doses of avian flu vaccine a year – but only if the production of vaccines for normal, seasonal flu were suspended, leading to an unknown number of deaths.
Azar said the federal government is distributing $100 million to the states for pandemic preparedness, of which Wisconsin is getting $1.8 million. States will receive a further $250 million later this year.
The new research center is being funded separately, with $6 million coming from the Wisconsin Alumni Research Foundation and a further $3 million from federal grants.
• More on WTN: IT critical in pandemic response, but many are not paying attention
Kawaoka
UW-Madison professor of virology Yoshihiro Kawaoka will direct the 20,000-square-foot institute, which will be housed in a remodeled building. His research into flu virus mutations has been lauded by the World Health Organization as one of the world's pre-eminent influenza projects.
Kawaoka was out of the country and unavailable for comment, but Bugher said the avian flu vaccine is "up there with stem cells" in terms of breakthrough technology. "The avian flu is being talked about almost every day in the international news," noted Bugher, who is working to develop a second University Research Park campus on Madison's Far West side. "If Wisconsin can become the centerpiece for avian flu research, and scientist Yoshi Kawaoka is certainly an acknowledged worldwide leader in that effort, I think it's a big deal."
Several of Kawaoka's discoveries on vaccine development have been patented by the Wisconsin Alumni Research Foundation, which is partially funding the institute. His technology will be refined in larger, more specialized laboratory space, and UW-Madison plans to add three new faculty positions in the area of viral vaccine research. Up to 28 people would be employed at the institute.
News of the institute, which should open by the fall of 2007, also makes it more likely that the state will hang on to the highly regarded Kawaoka, which Bugher acknowledged is "part of the strategy."
James Tracy, associate dean for research at the UW-Madison School of Veterinary Medicine, sees an additional benefit in commercial spin-offs. "The technology that Yoshi has devised will facilitate the production of new vaccines," Tracy said, "and his basic research could facilitate the discovery of new drugs of the ilk of Tamiflu."
Kawaoka is among a group of researchers that reported the existence of a Vietnamese girl with a strain of the H5N1 avian flu virus that is resistant to Tamiflu. As a result, the sole reliance on the drug, which is being stockpiled around the globe, has been called into question.
One of the challenges with influenza-A viruses is they mutate as they go through different organisms, either of the same species or when they jump species, which increases the degree of difficulty of making new flu vaccines. The work of Kawaoka's research group in the area of reverse genetics has enabled drug manufacturers to more quickly produce vaccines for new strains, and identify new molecular targets for anti-viral drugs. According to UW-Madison, a more recent discovery indicates how flu viruses organize their genetic material to create infectious particles.
Kawaoka's lab is studying the molecular basis of the high virulence of the H5N1 avian flu virus in mammals, and how it was directly transmitted from birds to humans. "His research is basically on the virus, itself, how it causes pathogenicity, and how it enters cells, and that provides the clues to the technology on how to make vaccines and drugs," Tracy said.
Want to hear more about pandemic flu, and how technology will be called on to help deal with it? It's one topic of the Digital Healthcare Conference in Madison on May 3-4. Visit the site now.


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Think Snow
larrymccoyonline.com
2020 Questions
Tribute to Rex Heathcote
A Walk For The Ages
Bright Side of a Firing
Macy's Mattress
On Being 82
Rubes In the Big Apple
Night Hawks
Time Out In A Small Town
My Brace And I
Uncle Ernest
Email To Mitch McConnell
Letter to Trump
Angry And Ashamed
A Diamond Of Our Own
Yellow Jello
Acting Like An Adult
Austria, Lufthansa & Me
Preparing For Austria
Economic Pain Without DJT
Regarding Your Resume
A Suave Lady's Man
Future Holiday Gifts
Jimmy The Horse
Year In Review -2043
My 81st
Latest Essay
Farewell to Rex Heathcote
When you're 82, a lot of your former newsroom mates are no longer around. An email in late October told me of the death of Rex Heathcote, the first New Zealander I ever met. Because of his background, I'd like to think Rex would have given this Yank a thumbs up for using "mates" in my lead.
He was an editor in the Central Newsroom of Radio Free Europe in Munich and possessed a high voice and a quick wit. We worked many nights together, and sometimes I gave him a ride home. He frequently invited me in for a drink, and, being single, he served expensive single malt whiskeys.
After a few years, Rex began dating Helga, a German teletype operator at RFE. I would see him come back from dinner in the cafeteria and leave a candy bar by her machine. He was learning German, and I think became quite proficient.
He and Helga married and had two daughters. He retired in 1994 and in 2007 Rex took his family to New Zealand to live. Even as his health deteriorated, Rex wrote emails worth reading.
Here's probably the last one I got from Rex, received in March:
… I am in my 87th year. A regular GOB. That's a Grumpy Old Bugger. I have moved to a quiet country town here called Carterton in the North Island of NZ. You might suppose it is named after your eminent president of the US, Jimmy Carter, who travels the world doing good deeds. Well, actually, no it isn't. We live in a big single level house surrounded by an orchard supplying a dozen different kinds of fruit.
I might look like a GOB but I am really enjoying life. I wish you the same Larry.
Cheers. Rex
Helga sent me a video link to Rex's funeral service. It's amazing, I think, how little we know about some people we see nearly every day for years. Because of my inability to leave work at work, I suspect that most of our conversations were about the office. I did know that Dudley was his first name, but he used his middle name, Rex.
During the funeral service, I learned that Rex's father had been shot down in the Cologne, Germany area during World War Two. I never knew that, don't remember even a hint about it from Rex. He never disclosed the news about his dad to his German mother-in-law who had lost her own family in the war. Nor did he tell Helga and his daughters about how his father died until after the mother-in-law's death. Helga did some research and found where Rex's father was buried, and he visited the grave before going home to New Zealand.
Rex came up with one of my favorite lines. I always had trouble staying in any newsroom more than six or seven straight years, working at UPI three times, and both CBS News and RFE twice. Rex once told me, "I like your going-away parties. I go to every one of them."
Another good man and fine journalist has left us.


text:
NYTimes Reporter: Obama 'Greatest Enemy To Press Freedom In A Generation'
Andra August 17, 2014 0 Comments
Obama, Obama 'Greatest Enemy
President Barack Obama is no friend of press freedom, says a New York Times reporter who may be sent to jail for refusing to reveal a source.
"A lot of people still think this is some kind of game or signal or spin," reporter James Risen told his own paper in a profile about his plight published Saturday. "They don't want to believe that Obama wants to crack down on the press and whistle-blowers. But he does. He's the greatest enemy to press freedom in a generation."
Risen's troubles stem from the 2006 publication of his book "State of War," which included classified information about a failed CIA plot against Iran's nuclear program. In 2008, George W. Bush's Department of Justice subpoenaed Risen to reveal the source of the classified information. Citing his role as a journalist, Risen refused to comply, fighting the subpoena until it expired in 2009.
But the Obama administration renewed the subpoena in 2010. After many more years of legal fisticuffs, the Supreme Court announced in June that it would not take Risen's appeal, leaving Risen out of legal options. Now Risen faces the specter of jail time if the Justice Department continues to insist that he reveal his source for the classified information.
"Though the court's decision looked like a major victory for the government, it has forced the Obama administration to confront a hard choice," the New York Times reported in June in the aftermath of the Supreme Court's ruling. "Should it demand Mr. Risen's testimony and be responsible for a reporter's being sent to jail? Or reverse course and stand down, losing credibility with an intelligence community that has pushed for the aggressive prosecution of leaks?"
Other useful resources:
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Conquering the coming collapse (Financial advice and preparedness )
Liberty Generator (Easy DIY to build your own off-grid energy source)
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Source : gopthedailydose.com
Rice helping Obama juggle foreign policy crises
RUSSIA Wants To Join Forces – Putin Calls for a U.S. & Russia Coalition to Defeat-ISIL
Obama's Final 100 Days! Is This The Beginning Of THE END?! Guess What President Barack Obama Just Did!


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Asma Jahangir- An Exceptional Human Rights Activist Is No More
in Human Rights / South Asia — by Dr Vivek Kumar Srivastava —	February 12, 2018
Asma Jahangir (1952-2018), the leading Human Rights activist of Pakistan who influenced generations of activists in South Asia is no more. She died in Lahore due to a cardiac arrest. A sad news for all those who has stood for the human rights protection and enhancement of the humane values in the contemporary world. Whenever any issue of human rights emerged in Pakistan she was there to take lead and impress the authorities to take the right path.
She took the cause of human rights in 1980s.a time when these concepts and issues were considered as a western ideas but she succeeded in placing the human rights issue in the centre of the mainstream political discussions which helped to restrain the unrestricted powers of the political leaders by awakening the masses.
She took the cause in true spirits and confronted two military rulers. She was a key activist in 2007 Judicial movement against the military leader in Pakistan which gradually led to the establishment of democratic political system in Pakistan.
She cofounded the Human Rights Commission in a country where authoritarian and retrogressive forces always dominated, where the space for women, weaker section was always restricted to live honoured life. She fought for these and her multidimensional work encompassed the women who were oppressed, the bonded labours which has been a persistent problem in the South Asian society, also confronted with unflinching spirit the orthodox communities with unflinching spirit.
All these are noteworthy contribution to the cause of human rights due to one major fact that in the human rights movement she placed the women as contributor higher than the contribution of the males. No one in South Asia including Pakistan can match her contribution and this makes her unique women and an activist who is class apart as she fought single handed and in that age when talks and discussions about human rights were considered as an issue beyond the domain of the common people.
Her death makes the society miser and human rights movement a little shaky in Pakistan as her continuous efforts in the conservative society will be missed. This is the time to realize the value of the leader and to take leanings and inspirations from such great souls. Her message is clear that human rights protection is possible only by sustained and collective efforts as people in power create often the barriers for free and dignified living in order to maintain their power structure. She spoke at the 34th session of the Human Rights Council, Geneva, 13 March 2016 that 'broad and vague definition of certain offences, disrespect for the right of any accused to be promptly informed about charges against him or her, preventing the accused from freely choosing their legal representation are all contributing factors to violations of the right to fair trial and due process of law.' This is her one of the last analysis of human life at a global platform.
Her departure from the stage of earth which is meant for only courageous and committed people for a cause is now full of vacuum. It will take time to fill the void as people like her rarely visit the planet. It is a pressing time and need is to realize her contribution and work in unison to protect the lives of all those who are at margin of their fundamental rights.
Dr. Vivek Kumar Srivastava, Assistant Professor, CSJM University, Kanpur; e mail: vpy1000@yahoo.co.in
Tags: Asma Jahangir


text:
Saint-Benoît-de-Frédefont, connu sous la Révolution sous le nom d'Agros, est une ancienne commune du Tarn, supprimée en 1832. Le bourg de Saint-Benoît-de-Frédefont est annexé par la commune de Lamillarié. Le village de Poulan, rattaché à la commune en 1830, en est détaché, pour former avec l'ancienne commune de Pouzols la nouvelle commune de Poulan-Pouzols.

Notes et références

Ancienne commune dans le Tarn

redpajama_set_name: RedPajamaWikipedia


If by mistake you miss a word will shown separately in result that you missed something. When you slow down and try to be accurate, you will feel relaxed and more in control. Mutual intelligibility decreases in literary and specialised contexts, which rely on educated vocabulary drawn from different sources; Hindi drawing its specialised vocabulary from Sanskrit, whilst Urdu does so from Persian and Arabic. After you type a word in english and hit a spacebar key, the word will be transliterated into hindi. Place your right index finger in 'j' button and left one is in 'f'.
Do not go back Most people have the bad habit of typing with only two fingers or a few fingers. प्रश्न- मैं यह सॉफ्टवेयर केसे क्रय कर सकता हु? Always practice typing to become an expert touch typist. These are theoretical discussion of free typing test lessons online. Use basic keyboard shortcuts to navigate faster When you use shortcuts, your hands are still on the keyboard. Our typing software is very easy to operate and build with international standard. Divide your practice in many short periods.
If you want to type 'म', then press 'C' or you want to type 'ण', then press 'shift + C'. If you keep at least one or both the thumbs on the space bar, you will never need to shift your hands around to type one or more spaces between two words. Imagine you are typing 60+ hours more every year because of your slow typing speed. So he is ahead of Spanish and English! The two most popular and crystal clear font for Hindi Typing. Licence is non-transferable to other system. The Indian constitution, adopted in 1950, declares Hindi shall be written in the Devanagari script and will be the official language of the Federal Government of India. Cash on delivery is not available.
When your index fingers rest on the F and J keys, your other fingers will naturally fall into other keys. These are the golden rules of Hindi typing online. It has taken words from the Dravidian languages of South India, many words from the Persian, Arabic, Turkish, English, and Portuguese languages. You are able to choose typing test platform as per your requirement. . Most government documentation is prepared in three languages: English, Hindi, and the primary official language of the local state, if it is not Hindi or English.
There are many free typing speed test software available in the market, but here you can test your speed online and it's free. Eventually, speed will follow you. This way your muscle memory will grow. उत्तर- आप ऑनलाइन भुगतान करके सोफ्टवेयर क्रय कर सकते हैं।. A mock test of 10minutes will be provided prior to the test. However, the constitutional directive to champion the spread of Hindi was retained and has strongly influenced the policies of the Union government. Going beyond typing, users will also be able to enhance typing skills by measuring key metrics like Accuracy Level, Speed, Words Typed Per Minute etc.
Colloquial Hindi is mutually intelligible with another register of Hindustani, Modern Standard Urdu, which is associated with the Muslim religion. But there are two things to remember. Check your Hindi Typing Speed also. एक लाइसेंस केवल एक सिस्टम के लिये ही वैध हैं, लाइसेंस गैर हस्तांतरणीय हैं। 5. Please do not expect to see good typing speed within a short period of time.
However, widespread resistance to the imposition of Hindi on non-native speakers, especially in South India such as the anti-Hindi agitations of Tamil Nadu and in West Bengal, led to the passage of the Official Languages Act of 1963, which provided for the continued use of English indefinitely for all official purposes. So, feel free to slow your typing pace until you can attain 100% accuracy. हिन्दी और इंग्लिश टायपिंग दोनों सीखे एक ही सॉफ्टवेयर से । 02. कोई छिपी लागत नहीं 4. उत्तर- लाइफ टाइम लाइसेंस एक सिस्टम के लिये. It's a simple portal where you can set the time and test your typing speed. But expects use the correct finger to press every key.
First you need to know the home position of finger. Adding Hindi as a display language and adding Hindi keyboards or input methods is as easy as clicking a few buttons. Hindi typing is a difficult job. We strongly hope you will find this super-easy to follow. Type at a desk or table. After the Chinese, he is in second place. Question- Which Operating System Supported? Our site saves your typing test online.
Typing is a fundamental job requirement for these jobs. Word File Ctrl + V Paste 4. It will be useless even if you look at the keyboard. This is useful in the event of crash or sudden shutdown of your computer. Ans- Software can be purchased from website by making online payment.


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MainAll NewsInside Israel'Netanyahu promised clusters, not isolated communities'
'Netanyahu promised clusters, not isolated communities'
Karnei Shomron Mayor Yigal Lahav explains support for sovereignty plan, calls on settlement leaders to speak with one voice.
Tags: Binyamin Netanyahu Yigal Lahav Judea And Samaria Sovereignty
Nitzan Keidar , Jun 08 , 2020 11:01 PM
council heads meet with Netanyahu
Karnei Shomron Mayor Yigal Lahav met with Prime Minister Binyamin Netanyahu Sunday and received from him a promise that sovereignty would be applied to all Jewish communities in Judea, Samaria, and the Jordan Valley.
"He said that on July 1 he would submit to the Knesset plenum a proposal to apply sovereignty to all localities and to all authorities without exception in Judea and Samaria. It could not be any clearer," Lahav said in an interview with Arutz Sheva.
He said that during the meeting, many points that had been vague were clarified. "This is the first time we have heard firsthand about the plan. So far, there have been rumors and statements about what is there and what isn't. I think the meeting was very important and we made it clear to the prime minister that it cannot be that we receive information regarding our daily lives from all kinds of sources."
"Netanyahu understood this and asked that the information now flow more transparently and clearly. As for the maps and the partners in their preparation, it was made clear to us that there is no precise map that refers to the area but something more abstract,and he said that we would be involved in the mapping stages to create a fabric of life that people could live with. Clusters will also be created for the isolated localities so they will not be isolated, and it will also be guaranteed that Israeli forces will maintain control of the roads."
Lahav said that he is disappointed with the dispute which has broken out with the heads of the Yesha Council, who have strongly criticized Prime Minister Netanyahu and the Trump Administration over the way sovereignty is being applied. "I know there was a meeting a week ago which we did not know about and I don't know who organized it. Therefore, to this meeting with the prime minister, everyone who was not at the previous meeting was invited to hear the messages from the prime minister. For whatever reason, we heard very clear answers which were less clear to our colleagues."
"The first thing I did this morning was to tone down the rhetoric in the Yesha Council, to say that we can have a free discourse without descending into baseless hatred. We are the heads of the authorities, and behind us are half a million people who are waiting for us to clarify things for them, so we cannot afford to be confused. There should be a uniform message page that goes out to all authorities and residents explaining what the situation is and what the challenges are. Obviously, not everything will go smoothly and there will be more struggles to achieve better results," the mayor of Karnei Shomron concluded.


text:
Fiolka – jedyny solowy album Fiolki Najdenowicz wydany w 12 marca 2001 nakładem wytwórni Sony Music.

Płyta zdobyła Fryderyka 2001 w kategorii "Album Roku - Techno / Elektronika / Dance", Fiolka Najdenowicz zdobyła nominację w kategorii "Wokalistka Roku" a Leszek Biolik był nominowany za tę płytę w kategorii "Producent Muzyczny Roku". Singel "Głośny śmiech" dotarł do 18-tego miejsca na Liście przebojów Programu Trzeciego (notowanie z dnia 13 kwietnia 2001, siódmy tydzień na liście).

Lista utworów
opracowano na podstawie materiału źródłowego
 "Zostawiłeś..." – 3:24sł. tradycyjne/Fiolka; muz. trad./Leszek Biolik
 "Głośny śmiech" – 4:14sł. Jacek Bieleński; muz. Leszek Biolik i Wojciech Seweryn
 "Komu ja" – 3:33sł. tradycyjne/Grzegorz Ciechowski; muz. trad./Leszek Biolik
 "Bpeteho, (Ureteno)" – 3:14sł. tradycyjne; muz. trad./Wojciech Seweryn
 "Niebieskie" – 4:21sł. tradycyjne/Fiolka; muz. trad./Leszek Biolik
 "Nie ma nic" – 4:53sł. Fiolka; muz. Leszek Biolik
 "Amen" – 4:29sł. Grzegorz Ciechowski; muz. Grzegorz Ciechowski, Leszek Biolik, Sławomir Ciesielski i Zbigniew Krzywański
 "Takim go kocham" – 4:38sł. Grzegorz Ciechowski; muz. Leszek Biolik i Michael Jones
 "Znua (Żmija)" – 6:05sł. tradycyjne; muz. trad./Leszek Biolik
 "Filigrany i moriole" – 4:31sł. Lech Janerka, muz. Wojciech Seweryn
 "Głośny śmiech (remix - Bon Air)" – 4:08sł. Jacek Bieleński; muz. Leszek Biolik i Wojciech Seweryn

Pozostali twórcy
opracowano na podstawie materiału źródłowego
 Leszek Biolik – produkcja muzyczna, programowanie instrumentów, gitara basowa, gitara, instrumenty klawiszowe, instrumenty perkusyjne, śpiew
 Bartosz Dziedzic – programowanie instrumentów
 Magda Femme – wokal wspierający
 Krzysztof Głuch – instrumenty klawiszowe
 Mike Jones – skrzypce
 Jakub "Kuba" Majerczyk – programowanie instrumentów
 Renata Przemyk – śpiew
 Wojciech Seweryn – gitara akustyczna, wokal wspierający, gitara, instrumenty klawiszowe

Przypisy

Linki zewnętrzne
 Fiolka robi raz, a dobrze! – artykuł z zapisem dźwiękowym poświęconej albumowi Fiolka audycji radiowej Anny Gacek i Tomasza Żądy z cyklu Historia pewnej płyty, Polskie Radio Program Trzeci, czerwiec 2010

Albumy Sony Music Entertainment Poland
Albumy muzyczne wydane w roku 2001


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So today I watched a video clip of an irate parent who went to the news because a teacher at an elementary school "jumped on the hood of her car". I was curious so I watched. What I quickly realized is how the story was incredibly one sided and highly annoying as the teacher was berated for attempting to stop a parent who refused to follow school safety rules. In this video Hal Boman ( Teach Like a Rockstar) gave an amazing commentary about the teacher in the video and gave insight into what is really like for teachers and administrators when it comes to the safety of the students we serve, by doing whatever it takes to get the job done.
Adults need to set good examples for their children and stop thinking that rules don't apply to them. If parents want to make their own rules for school then by all means opt for Home School.
Second has anyone stopped to realize that educators are not trained security officers? When you see us standing in the middle of the street directing traffic for hundreds of parents to pick up and drop of their children in a SAFE and ORDERLY fashion it's done while putting our lives at risk with limited resources. In my past experience I had to get funds donated just to purchase safety cones and reflective vests for staff to add an additional layer of support.
Third We have to change the narrative about happens in our schools. Instead of the teacher Mr. Aaron Morgan being praised for being a leader and protecting children's safety by any means necessary we allow a parent to get valuable airtime to bad mouth yet another teacher. I wanted to hear the news broadcaster ask questions to have Rita take responsibly of her actions, but sadly that didn't happen. Rita was trespassing , driving the wrong way, and refusing to follow directions UNACCEPTABLE- howboutdat??!!!!
Educators need to stand up and start demanding that our schools be deemed a safe place for students to learn and adults to work. Continue doing whatever it takes to change the narrative of what happens in schools and what real leaders do every day! Whatever it takes! Even if it means that we jump on the hood of a car of parent who is putting the lives of children in danger in the car riding zone!
Click here to support this teacher Aaron Morgan for holding adults accountable by signing this petition.
Teacher appreciation week is one of my favorite times of the year. As a former principal I looked forward to surprising my staff and showing them appreciation. I believe in going all out for people when showing appreciation and it was no different as a principal. Educators can often feel overwhelmed with their constantly changing busy schedules, grading papers, lesson plans, and classroom management among other daily activities. So teacher appreciation is just one of many times of the year that teachers and staff can feel special. I would have my plan already in place during the start of the school year. Normally there would be a theme that was closely connected to the school wide theme for the year.
My plan was pretty simple- Food, Gifts and Activities. My staff loved to eat (so did their leader LOL) so it was a no brainier that there would be days centered on food. The week normally started off small with a treat bag or something in the snack realm then lead up to a big luncheon style fest. One year for the school theme: Building on our Success, each day had a "Build your Own" food theme. Build your own yogurt parfait, Build your own Sundae, Build your own waffle station, and lastly a cookout with a Build your own hamburger station.
You must enjoy working with adults in the same manner as you enjoy working with students. Ever met a teacher who didn't like children and wondered why they went into education in the first place? Those are the same thoughts I have when I talk to principals who don't like working with adults. Ummu hello that's a large part of your job.
When you recognize staff members year long and are genuine in your appreciation it becomes a part of your school culture. I would do random interruptions with a snack cart, or stickers and even raffles for free 100 colored copies. The crowd favorite were the quick handwritten notes that I left in classrooms on sticky notes. It was a quick way to recognize the work that they were doing- they loved it. No one really wants a gift from someone who has been unpleasant towards them year round or has not built a relationship with them. In addition, as a leader if you haven't built genuine positive relationships with your staff you won't feel a desire to honor and appreciate staff.
Remember that rewarding teacher actions can go a long way. Treating the teachers with respect and gratitude will result in happy and motivated teachers. With a happy and motivated staff, there will be a good working environment which will result to teachers who strive to do a good job. It also promotes a sense of belonging causing the teachers to desire to make the school a better place.
That's me frying bacon for the the staff!
I am KRiley also known as the #principalnerd. I am passionate about education and helping others I am a coach at heart. There are so many people who are working with students daily and they need help being successful and I want this platform to be the place for that. Are you are an educational leader looking for resources and and support? Then you have found the right place. Look for regular posts that are designed to be real, honest and helpful. Lets change the face of educational leadership for the better by growing better leaders!


text:
NextMadFriars Interview: Tirso Ornelas
Daily Farm ReportFeatured
San Diego Padres Daily Farm Report: August 26
Mark Wilkens	on August 27, 2021
The El Paso Chihuahuas split with Sugar Land thanks to dropping a resumed game from August 3rd, the Missions and Storm both took losses to their opponents as the TinCaps lost to Mother Nature. In the desert, the last of the Padres' 2021 draft class made his professional debut.
Brian O'Grady has gotten hot again for the El Paso Chihuahuas. (Photo: Jorge Salgado)
Game 1: Sugar Land Skeeters 9, Chihuahuas 2 (Suspended on Thursday)
Key Stats: DH Brian O'Grady, 1-for-3, HR, R, RBI; CF Matt Batten, 1-for-3; RHP Parker Markel, 1.1 IP, 0 H, 0 R, BB, 2 K
Prospect Watch: Talk about a tough day, less than 24 hours after Daniel Camarena took the loss in a 16-inning heartbreaker at Petco Park, he's booked for the loss in a game he started on August 3rd, resumed tonight in El Paso with the Chihuahuas as the visiting team in their own ballpark. … With action picking up with El Paso down 7-1, the only Chihuahuas run in this game tonight came courtesy of a Brian O'Grady solo shot in the 9th. By the calendar, this was O'Grady's third hit in as many games, but, of course, this statistic will go back in time to August 3rd. … It took 24 days for it to count, but Matt Batten added a single while playing center field. The 26-year-old Batten, a 32nd rounder in 2017 out of Quinnipiac, has made appearances in all three outfield spots, second base, shortstop, and third base, and also five mop-up appearances on the mound for the Chihuahuas.
Evan Miller has been a key contributor to the El Paso pitching staff. (Photo: Jorge Salgado).
Game 2: Chihuahuas 11, Sugar Land Skeeters 6
Key Stats: RHP Evan Miller (W, 3-3), 2.2 IP, 2 H, 1 ER, BB, 3 K; C Luis Campusano, 2-for-4, 2B, R, RF Brian O'Grady, 2-for-4, R; SS Matt Batten, 3-for-3, 2B, 3 R, 2 RBI; 2B Ivan Castillo, 2-for-3, 2B, R, 3 RBI;
Prospect Watch: All it took was a change into the dazzlingly fluorescent uniforms of the El Paso Margaritas and a switch back to being the home team. El Paso put the Skeeters in a blender with an offense which delivered 14 hits and scored 11 runs without hitting a single home run in the notoriously atmospheric Triple-A West. The win in this high-scoring affair went to Evan Miller, who struck out three in 2.2 innings, allowing two hits and one earned run. Miller, a product of Indiana-Purdue Fort Wayne, is 1-0 with a 9.26 ERA in August, but his 1.46 WHIP is his lowest of any month this season. He's 2-1 with a 4.32 ERA in games played at Southwest University Park, while 1-2 with a 6.28 ERA away from El Paso. … There was a catcher batting leadoff tonight as Padres' core prospect Luis Campusano set the table tonight with two hits, including a double. Campusano's scorching August has produced a slash line of .372/.471/.674, good for an OPS of 1.145 for the month, continuing a trend of improving with the bat each month of the 2021 season. After going hitless in five of six games in the middle of the month, Brian O'Grady has continued to return to form, adding a pair of hits tonight to continue a three-game hitting streak. The 29-year-old O'Grady, signed in the off-season by the Padres as a free agent, has a .951 OPS in August for El Paso, nothing to look down upon, unless you include his 1.162 OPS in May and his 1.269 OPS in July. … The previous game's center fielder moved back to his more familiar shortstop, and Matt Batten responded with a trio of base knocks for the El Paso Margaritas. Batten is slashing .291/.378/.389 for El Paso in the 2021 season. … Two hits and three RBIs punctuated a solid evening for Ivan Castillo. The switch-hitting Castillo, who made his major league debut this year with the Padres, is batting .189 vs lefties, and .302 against right-handers this season.
Allen Cordoba is having one of his best seasons at age 25. (Photo: Rey Holguin)
Midland RockHounds 3, Missions 2
Key Stats: 1B Allen Cordoba, 2-for-4, 2B, R; LF Michael Curry, 2-for-4, HR, R, 2 RBI; LHP Sam Williams, 2 IP, 2 H, 0 R, 0 BB; RHP Jordan Humphreys, 2 IP, 3 H, 0 R, BB; RHP Carlos Belen, 2 IP, H, 0 R, 0 BB
Prospect Watch: San Antonio saw a 2-1 lead from a Michael Curry home run vanish quickly in the fourth, but the bullpen worked hard to keep the Missions in the game all evening. Curry's seventh home run of the year has put him in double-digit RBI totals for the second month in a row. All seven of his big flies have come in July and August, and in August his increased plate discipline has been paying dividends, with 14 walks to go against his 19 strikeouts in 73 at-bats. … 25-year-old Allen Cordoba is a familiar name to Padres fans after spending 2017 in San Diego after the Rule 5 Draft. After a series of injuries and the pandemic, Cordoba is back in action and playing some the best ball of his professional career. His two hits tonight continue a blazing
All seven of Michael Curry's home runs have come in the past two months. (Photo: Joe Alexander)
August in which he's slashing .384/.451/.534 for the Missions. … Two scoreless innings on the part of Sam Williams continued his solid work since returning to the Missions on August 12th. Williams, a 25-year-old lefty out of Northern Kentucky, has allowed one earned run in 5.2 innings while striking out seven and walking two for San Antonio this month. … Tonight marked the third straight scoreless outing for Jordan Humphreys. Humphreys, a 25-year-old righty from Crystal River, Florida, was selected off waivers by the Padres in February of this year via the Giants organization. An 18th round selection by the New York Mets in 2015, Humphreys has also spent time in the Cleveland organization in between stints with the Giants. … Also throwing a deuce of scoreless innings was Carlos Belen, the 25-year-old from Santo Domingo in the Dominican Republic. Belen is 2-0 with a 0.66 ERA and 0.95 WHIP in 13.2 innings across eight appearances in the month of August.
The TinCaps saw their game at ParkView Field against the Dayton Dragons suspended in the second inning due to rain. The game will resume as part of a Friday doubleheader between the two clubs.
San Jose Giants 10, Storm 3
Key Stats: RHP Dinelson Lamet, 2 IP, 1 H, 0 R, 0 BB, 3 K; RHP Miguel Rondon, 2 IP, H, 0 R, BB, 2 K; RHP Alek Jacob, 2 IP, 2 H, 0 R, 0 BB, K; SS Euribiel Angeles, 3-for-4, RF Joshua Mears, 1-for-4, 2B, R; DH Colton Bender, 1-for-4, R, RBI
Prospect Watch: Despite a few impressive performances at the plate and some solid relief pitching, this game was a blowout before it even really got going, with a 10-run second inning for San Jose. Not only did Dinelson Lamet pitch two innings in his third appearance for the Storm, he did so on a day's rest, both encouraging signs for Padres fans as he seeks to return to the majors as a reliever this season. This time, he allowed only one hit, and walked none in two scoreless innings of work. … Tonight marked the first scoreless appearance of the six made by Miguel Rondon since returning to Lake Elsinore from the Arizona Complex League. Rondon, a 20-year-old righty, signed with the Padres in the summer of 2017. … 2021 16th rounder Alek Jacob continued his impressive start to his professional career, bringing his scoreless innings
Euribiel Angeles is the leader for the Low-A West batting title. (Photo: Jerry Espinoza)
streak to 9.2. Jacob, a 23-year-old righty out of Gonzaga, has thrown all but one of those innings for the Storm, his first inning coming in the Complex League. … The fifth three-hit game of August for Euribiel Angeles has given him a nine-point lead in the race for the Low-A West batting title with his .342 average. The 19-year-old Angeles is slashing .342/.397/.459 in his first full season of professional baseball. … Nearly 51% of the hits off the bat of Joshua Mears have gone for extra bases, including tonight's double, his 10th of the year. The 20-year-old 2019 second-round pick's .946 OPS is good for second in the league. … 2021 10th round pick Colton Bender was sent to Lake Elsinore from the Complex League when several members of the Storm were held out of games due to COVID protocols, but Bender has yet to go back as he is now slashing .326/.362/.442 in 10 games for Lake Elsinore. Bender, a catcher from Quinnipiac, only played four games for the ACL Padres before his emergency promotion.
Jackson Merrill has impressed at the plate in his first pro season. (Photo: Jerry Espinoza)
ACL Cleveland 2, ACL Padres 1
Key Stats: CF John Andreoli, 1-for-3, HR, R, RBI; SS Jackson Merrill, 2-for-3, 2B; RHP Ryan Bergert, 1 IP, 0 H, 0 R, 0 BB, 2 K; RHP Kobe Robinson, 1 IP, 2 H, 0 R, BB, K
Prospect Watch: The lone run of the game for the Complex League Padres came off the bat of John Andreoli, who is on a rehab assignment from El Paso. The 31-year-old Andreoli was slashing .206/.347/.402 for El Paso before finding his way on the IL on June 16h. … Jackson Merrill bounced back from a rare hitless game with a two-hit performance, the third time in his last four games he's had two or more hits. The 2021 first round pick is slashing .333/.390/.449 in the first 20 games of his professional career. … After the third appearance of his professional career, Ryan Bergert has yet to allow a walk and has only allowed one hit in three innings while striking out four. Bergert, the Padres' sixth-round selection in 2021 out of West Virginia, is a 21-year-old right-hander who had been projected to be taken as high as the second round before missing the 2021 collegiate season due to an elbow injury. … The final 2021 debut in the desert for the 2021 draft class went to Kobe Robinson, who began his pro career with an adventurous inning, one which included two singles, a walk, two wild pitches, and none of those runs crossing the plate. 0.00 ERA, 3.00 WHIP for Robinson, who was the Padres' 13th round selection this summer out of Chattanooga State Community College, where the Tennessee native starred for two seasons.
Posted in: Daily Farm Report, Featured
Tagged in: alek jacob, Allen Cordoba, Brian O'Grady, carlos belen, colton bender, Daniel Camarena, dinelson lamet, Euribiel Angeles, evan miller, featured, ivan castillo, Jackson Merrill, John Andreoli, Jordan Humphreys, Joshua Mears, kobe robinson, Luis Campusano, matt batten, Michael Curry, Miguel Rondon, Parker Markel, ryan bergert, Sam Williams
Posted by Mark Wilkens
Born in San Diego and raised in Escondido, Mark now calls Phoenix home. Prior to MadFriars, Mark had multiple articles featured on Bleacher Report and SI.com covering the Padres, Angels and Clippers.
MadFriars Interview: Tirso Ornelas


Do you accept Jesus Christ as your Lord and Savior, and pledge your allegiance to his kingdom?
Do you profess the Christian faith as contained in the Old and New Testaments as your rule of faith and practice?
Will you, according to the grace given you, live a Christian life?
Will you be loyal to Cuthbert United Methodist Church, and uphold it with your prayers, your presence, your gifts, your service, and your witness?


I know I shouldn't be mean to statists. I shouldn't ridicule them or point out that they are no better than molesters. Even though it's true.
That's not how you get people to listen and (possibly) change. This knowledge requires a change in me. And that change is hard and unpleasant and unnatural.
Statism– the belief that governing others is a legitimate human endeavor– is ripe for ridicule. This notion that people can't be trusted to run their own lives, so we need to have some (who can magically be trusted– going against the original assumption) with power to run the lives of others is a demonstrable mess. It makes no sense. It is internally inconsistent. It doesn't work in the real world, with real people in real situations.
It's hard to not be mean to people who advocate something so stupid. It's hard to not point out how they promote evil acts. It's hard to not compare them to others who believed similar things with similar results.
I know I shouldn't, but it's not likely I'll stop. Too many people treat them with unearned respect and act as though they are actually contributing something to the human conversation. There needs to be another side to it. Someone needs to be pointing and laughing at their nonsense.


On appeal, George claimed that his original guilty plea was coerced and involuntary.
Mysore had to say that.
Lui can't speak French without making mistakes.
Nathan told me you had stopped by.
There's something under my bed.
I've a lot of work for tomorrow morning.
If Leo swims, I will, too.
I'll tell Sridhar when he gets here.
Vince is getting married next month.
Can you get Sandip to come to my party?
She asked him to give her some money.
You should not respect a man because he is rich.
Troy has the experience necessary.
Tell Jeff I don't have his keys.
I mentioned it to Saqib.
Barrio bought Barbara a nice present.
Lincoln's biography is read by children all around the world.
I didn't say a word for fear I should annoy him.
Martin didn't feel comfortable driving Joel's new car.
I asked Vilhelm some questions.
Bryce is in a ton of trouble.
Henry is painting his room.
Mario is going to stay in the Boston area.
He can no longer wait.
Theo looks a bit embarrassed.
Granville told Kathy not to play with fire.
How bad is Spass hurt?
I enjoy hanging out with Murat.
Kerry is the lead singer.
Cristina bought some patio furniture.
Is it true that Himawan went to Boston?
Bjorne is better at chess than I am.
Hillel is accustomed to speaking in public.
This hall is very big.
Is that what Matti thinks happened?
He mentioned the incident to his wife.
We were late to the party, like you.
Evan left a lot behind.
Nobody can deny the fact that the world economy is centered around the economy of the United States.
Herve is quite famous, isn't he?
I know you're upset about the fact that we broke up, but my attraction to Clay didn't have anything to do with it.
Barton laughed at the joke.
Saiid decided to enter the competition.
Real couldn't tell Stuart everything he knew.
Pat said he wanted to hear the truth.
Spike unlocked the door, and then stepped aside to let Antonio enter first.
I hope we can avoid doing that.


To bring his new music to life, Marc E. Bassy invited filmmakers and animators from around the world to create a lyric video for one of two of his latest tracks in 2015.
This musical artwork is a lyric video for "Faded" by Marc E Bassy. As requested, the main visual reference is Marc E Bassy's current aesthetic inspired by Roy Lichtenstein. In this video, I wanted to push further Marc's reference to the art world. I used Roy Lichtenstein's Ben-Day dots, Andy Warhol's bold colors and Stephen Sprouse's graffiti signature. I also wanted to recreate the feeling of being "Faded" and dazed. The objective was to have a video that looked groggy and disoriented.


I have decided to start a new segment as a way to "introduce" the new creative element to this blog, named Musical Interests as the title has shown. Since I have been listening, reading, writing, and exploring so much content in the musical and poetic world, I thought I should share some of the "gems" I stumble across, sometimes well known or sometimes not. Let's talk music!
To keep things concise, we all have memories from when we grow up, and naturally a segment of these memories comes from the music we hear and the bands that our parents listen to around the house. Cat Stevens (break the damn taboo already), Bon Jovi, Queen, and many classics (including classical music, which I both love and hate) comprise my more distant memories of music. More recently (perhaps six years at the most), there are the James Blunt car rides or Coldplay binges, coupled with a wider spectrum of music in general including country, folk, meringue, and many other genres. Overall, music has been a happy constant in my life.
One band that I had completely forgotten about however, and have only rediscovered recently, is the band Thriving Ivory, a sound that is definitely a familiar one to our home as we played them almost nonstop for months some years ago. From 2003 and onwards the band had released two albums and some singles, Angles on The Moon and Hey Lady some of the more well known and "hit" songs. We bought the albums, and loved every part of them. Thriving Ivory just has a unique sound in general, Scott Jason's amazing lyrics and Clayton Stroope's very interesting voice adding a refreshing sound to typical rock.
And then I found out they released an album in 2010, which somehow eluded my attention up until yesterday when I was reading their Wikipedia page (I do that for many bands now, it is always interesting). It showed the discography, and my mind was blown that there was a whole other set of music for me to listen to. Basically, it was a great highlight for the day, and I highly recommend checking out the music of Thriving Ivory. I have been listening to the old stuff and the new (new to me...it still came out in 2010), but the experience is the same as it was years ago.
So...That really is it for this blog post. I don't want to expand into a rant on how much I love their music, or turn it into an assignment where I write up a biography on every single detail about the musical journey of Thriving Ivory. I simply want to share some music I think is neat and a nice change to the monotony we have on current radio stations, and maybe give some readers out there something to listen to. Hope you guys check them out, and like them if you do.


Die US Prog-Metal Band WITHIN THE RUINS ist derzeit mit einem neuen Album beschäftigt. Die Aufnahmen haben begonnen, für den Mix der Scheibe konnte die Band Jason Suecof (All That Remains, August Burns Red) gewinnen. Produziert wird der Longplayer von Gitarrist Joe Cocchi in seinem eigenen Studio.
"This is the most time we have ever had to focus on writing. There are a ton of new aspects to this material. We are always aiming to create the most interesting and refreshing music that we are capable of, and I think we have finally been able to accomplish that with this album."


You must have the intention to fast before fajr (dawn) every night during the month of Ramadan. The intention does not need to be spoken, because in reality it is an act of the heart, which does not involve the tongue. It will be fulfilled by one's intention from the heart to fast out of obedience to Allaah ﷻ seeking His pleasure.
Pregnant and nursing women, who are afraid that fasting may weaken them or the child, have the option of fasting or not. After Ramadan ends, they have the choice of fasting or paying fidiyah (feeding one poor person) for each day that they had missed during Ramadan. However, according to the Hanafi School of jurists, such women are only to make up the missed days of fasting, and they are not supposed to feed one poor person a day. On the other hand, Imaams Ahmad and Ash-Shaaf'i, hold the opinion that if such women fear only for the baby, they must pay the fidiyah and make up the days later. If they fear only for themselves or for themselves and the baby, then they are only to make up the missed days at a later date.
Also we can earn rewards by supplicating at the time of breaking the fast, as the prophet ﷺ used to say, Dhahabadh-dhama-oo wabtallatil-'urooqu, wa thabatal-ajru inshaa'Allaah. Which can be translated as, "The thirst has gone, the veins are moistened and Allaah willing, the reward is confirmed."
To gain even more rewards, it is recommended that during Ramadan we increase our recitation and study of the Qur'an. This is because the revelation of the Qur'an began during this time, and also Angel Gabriel used to review the Qur'an with the Prophet during this month.


First let me express what a pleasure it is to use this amazing tool. I have used other tools designed for similar duties, but they were Never this smooth or even had anywhere close to this much usable power on the lower and upper end of the stroke length. To my suprise the airgraver started getting cooler to touch after use. Vibration during use is so insignificant you forget its an impact tool. I can not wait till a scope is in my life and give the light control a go. If your on the fence about an airgraver I promise you will not regret it. I can say that I obsess over all of my personal tools on their functionality vs cost. If this tool was lost or stolen, I would not think twice about getting another one.
The ring pictured was designed and built for a client. Center is an Exceptional round diamond cut Ceylon sapphire, the diamonds are all vs2-si1 quality set in a shared prong fashion made out of 18k. She loves it and said "Yes".
The classic airgraver is a great tool no doubt.
Hi Soco, Glad you're liking the Classic! The ring looks awesome! Thanks for posting it.
Keep me posted if you have any questions with the tool while working with it.


text:
<?php

namespace thinker_g\UserAuth\migrations;

use thinker_g\Helpers\migrations\CreationMigration;

/**
 * Migration for creating table of external user accounts.
 *
 * @author Thinker_g
 */
class ExtAccountMigration extends CreationMigration
{
    public $tables = [
        '{{%user_ext_account}}' => [
            self::K_COLS => [
                'id' => 'INT PRIMARY KEY AUTO_INCREMENT',
                'user_id' => 'INT',
                'from_source' => 'VARCHAR(64) NOT NULL',
                'access_token' => 'VARCHAR(255) NOT NULL',
                'open_uid' => 'TEXT NULL DEFAULT NULL',
                'email' => 'VARCHAR(255) NULL',
                'created_at' => 'TIMESTAMP NULL DEFAULT CURRENT_TIMESTAMP',
                'updated_at' => 'TIMESTAMP NULL',
            ],
            self::K_FK => [
                'fk_ext_account_user' => ['user_id', '{{%user}}', 'id', 'CASCADE', 'CASCADE']
            ],
            self::K_IDXS => [
                'idx_ext_email' => [
                    self::K_COLS => ['email', 'from_source']
                ]
            ]
        ], // user_account
    ];

}

redpajama_set_name: RedPajamaGithub


text:
Conversations Matter: the dangers of online one-stop-shop TGD info sites.
We've all had that experience. A runny nose, a cough or a sore throat sends us online for a quick digital diagnosis. When we re-emerge hours later its usually loaded up with a history lesson on horrible obscure diseases as well as the nagging feeling of an impending public health disaster. Crucuially, we often feel less safe, less empowered, and no healthier for all our new found knowledge.
There is of course nothing wrong with getting an internet opinion, especially from a reputable source. But if the internet age has taught us anything, it's the importance of talking with and getting advice from actual professionals.
For the transgender and gender diverse community this is vital. Anecdotally, TGD folk have always been incredibly resourceful at navigating their needs online, finding and gathering information and sharing it with the community. It's a model of knowledge transmission that we've used to keep ourselves safe; overcome gate keepers, understand our identities, access hormones, find supportive doctors, get advice on transition and connect with each other. But there are still dangers. Trans people have and continue to access and self-administer hormones, medical discrimination frequently leads to purchasing outside of the public health system, and unregulated DIY transition sites are easily accessible.
And while there are a few reputable, highly informative sites accessible in Australia, the issue around the best way to support the TGD community is still complicated. Well researched, up-to-date information on transition and TGD healthcare can never replace the front-line community-focused information that is most valuable to trans people. In other words, all the access in the world is not going to help you navigate the complex and shifting issues in and aroundTGD health. There is a danger too in providing information designed on the assumption that TGD people are digitally savvy, when the most vulnerable members of our community are older, culturally and linguistically diverse, and face fundamental challengesto accessing the internet or consistently paying for data plans.
Other dangers exist. While almost all TGD folk are able to access information and make their own decisions, there will always be a section of our community who don't have the capacity or (in the case of children) the maturity to do so without consequence.
Similarly, mental health remains a major hurdle for TGD folk. This is almost entirely due to the wear and tear that society's prejudice places on the daily lives of TGD people, but that wear and tear can be exacerbated by 'wall-of-text' sites and a lack of accessibility. Access after all is not the same as accessibility and access without accessibility makes things worse for the more vulnerable members of any community.
In all of these cases the solution is simple. Do provide information on TGD health and well-being, but only if you can also ensure accessibility. Trans and gender diverse people do best navigating the complex often discriminatory systems when they can access one-on-one support. Some TGD folk will never need this kind of support, but even they can save hours of time trawling through page after digital page with a quick call to the Gender Centre. And our most vulnerable community members find this one-on-one access vital. Any other model puts at risk our communities well-being.


GrubHub and Seamless has a promotion going on for new customers. If you sign up now, you can get a $10 discount on your first order or $15 or more.
GrubHub is similar to other delivery apps. You download GrubHub, register and then search for restaurants near you by entering your zip code. You should be able to choose almost all items that would be available in store. You can also choose between delivery or pickup. Deliveries can also be scheduled for later in the day, which is a pretty useful feature. I have used the app a few times in the past.
Tipping can be done in app, so no cash is necessary when you food is delivered.
There's a few similar apps out there, but if you haven't used GrubHub or Seamless yet, then it's worth trying out, at least just for the signup offer. Place an order of $15 or more and you will receive a $10 discount.