Gan LM, Lagerström-Fermér M, Carlsson LG, Arfvidsson C, Egnell AC, Rudvik A, Kjaer M, Collén A, Thompson JD, Joyal J, Chialda L, Koernicke T, Fuhr R, Chien KR, Fritsche-Danielson R. Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes. Nat Commun. 2019 Feb 20; 10(1):871. PMID: 30787295.
Chien KR, Frisén J, Fritsche-Danielson R, Melton DA, Murry CE, Weissman IL. Regenerating the field of cardiovascular cell therapy. Nat Biotechnol. 2019 Mar; 37(3):232-237. PMID: 30778231.
Sahara M, Santoro F, Sohlmér J, Zhou C, Witman N, Leung CY, Mononen M, Bylund K, Gruber P, Chien KR. Population and Single-Cell Analysis of Human Cardiogenesis Reveals Unique LGR5 Ventricular Progenitors in Embryonic Outflow Tract. Dev Cell. 2019 Jan 31. PMID: 30713072.
Xu J, Gruber PJ, Chien KR. SMAD4 Is Essential for Human Cardiac Mesodermal Precursor Cell Formation. Stem Cells. 2018 Oct 30. PMID: 30376214.
Sahara M, Eroglu E, Chien KR. Lnc'ed in to Cardiogenesis. Cell Stem Cell. 2018 Jun 01; 22(6):787-789. PMID: 29859167.
Carlsson L, Clarke JC, Yen C, Gregoire F, Albery T, Billger M, Egnell AC, Gan LM, Jennbacken K, Johansson E, Linhardt G, Martinsson S, Sadiq MW, Witman N, Wang QD, Chen CH, Wang YP, Lin S, Ticho B, Hsieh PCH, Chien KR, Fritsche-Danielson R. Biocompatible, Purified VEGF-A mRNA Improves Cardiac Function after Intracardiac Injection 1 Week Post-myocardial Infarction in Swine. Mol Ther Methods Clin Dev. 2018 Jun 15; 9:330-346. PMID: 30038937.
Foo KS, Lehtinen ML, Leung CY, Lian X, Xu J, Keung W, Geng L, Kolstad TRS, Thams S, Wong AO, Wong N, Bylund K, Zhou C, He X, Jin SB, Clarke J, Lendahl U, Li RA, Louch WE, Chien KR. Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction. Mol Ther. 2018 Jul 05; 26(7):1644-1659. PMID: 29606507.
Eroglu E, Chien KR. Heart Regeneration 4.0: Matrix Medicine. Dev Cell. 2017 07 10; 42(1):7-8. PMID: 28697334.
Zangi L, Oliveira MS, Ye LY, Ma Q, Sultana N, Hadas Y, Chepurko E, Später D, Zhou B, Chew WL, Ebina W, Abrial M, Wang QD, Pu WT, Chien KR. Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury. Circulation. 2017 Jan 03; 135(1):59-72. PMID: 27803039.
Soh BS, Ng SY, Wu H, Buac K, Park JH, Lian X, Xu J, Foo KS, Felldin U, He X, Nichane M, Yang H, Bu L, Li RA, Lim B, Chien KR. Corrigendum: Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells. Nat Commun. 2016 07 19; 7:12118. PMID: 27431579.
Soh BS, Ng SY, Wu H, Buac K, Park JH, Lian X, Xu J, Foo KS, Felldin U, He X, Nichane M, Yang H, Bu L, Li RA, Lim B, Chien KR. Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells. Nat Commun. 2016 Mar 08; 7:10774. PMID: 26952167.
Ljunggren HG, Chien KR. Next generation partnerships in translational science and medicine: Partnerships between academics, big pharma, biotech firms, philanthropists and patients look set to change the way science advances. EMBO Rep. 2015 Oct; 16(10):1246-9. PMID: 26358954; PMCID: PMC4766463 [Available on 10/01/16].
Sahara M, Santoro F, Chien KR. Programming and reprogramming a human heart cell. EMBO J. 2015 Mar 12; 34(6):710-38. PMID: 25712211; PMCID: PMC4369310.
Sahara M, Hansson EM, Wernet O, Lui KO, Später D, Chien KR. Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells. Cell Res. 2015 Jan; 25(1):148. PMID: 25553820; PMCID: PMC4650595.
Lui KO, Howie D, Ng SW, Liu S, Chien KR, Waldmann H. Tolerance induction to human stem cell transplants with extension to their differentiated progeny. Nat Commun. 2014 Dec 01; 5:5629. PMID: 25434740.
Später D, Hansson EM, Zangi L, Chien KR. How to make a cardiomyocyte. Development. 2014 Dec; 141(23):4418-31. PMID: 25406392.
Soh BS, Buac K, Xu H, Li E, Ng SY, Wu H, Chmielowiec J, Jiang X, Bu L, Li RA, Cowan C, Chien KR. N-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment. Cell Res. 2014 Dec; 24(12):1420-32. PMID: 25367124; PMCID: PMC4260345.
Drawnel FM, Boccardo S, Prummer M, Delobel F, Graff A, Weber M, Gérard R, Badi L, Kam-Thong T, Bu L, Jiang X, Hoflack JC, Kiialainen A, Jeworutzki E, Aoyama N, Carlson C, Burcin M, Gromo G, Boehringer M, Stahlberg H, Hall BJ, Magnone MC, Kolaja K, Chien KR, Bailly J, Iacone R. Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells. Cell Rep. 2014 Nov 06; 9(3):810-21. PMID: 25437537.
Chien KR, Zangi L, Lui KO. Synthetic chemically modified mRNA (modRNA): toward a new technology platform for cardiovascular biology and medicine. Cold Spring Harb Perspect Med. 2014 Oct 09; 5(1):a014035. PMID: 25301935.
Lian X, Xu J, Li J, Chien KR. Next-generation models of human cardiogenesis via genome editing. Cold Spring Harb Perspect Med. 2014 Sep 18; 4(12):a013920. PMID: 25237142.
Lui KO, Zangi L, Chien KR. Cardiovascular regenerative therapeutics via synthetic paracrine factor modified mRNA. Stem Cell Res. 2014 Nov; 13(3 Pt B):693-704. PMID: 25043723.
Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, Wang DZ, Li K, Wang J, Wanders RJ, Kulik W, Vaz FM, Laflamme MA, Murry CE, Chien KR, Kelley RI, Church GM, Parker KK, Pu WT. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nat Med. 2014 Jun; 20(6):616-23. PMID: 24813252.
Sahara M, Hansson EM, Wernet O, Lui KO, Später D, Chien KR. Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells. Cell Res. 2014 Jul; 24(7):820-41. PMID: 24810299; PMCID: PMC4085760.
Bang ML, Gu Y, Dalton ND, Peterson KL, Chien KR, Chen J. The muscle ankyrin repeat proteins CARP, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to pressure overload. PLoS One. 2014; 9(4):e93638. PMID: 24736439; PMCID: PMC3988038.
Feinberg AW, Ripplinger CM, van der Meer P, Sheehy SP, Domian I, Chien KR, Parker KK. Functional differences in engineered myocardium from embryonic stem cell-derived versus neonatal cardiomyocytes. Stem Cell Reports. 2013; 1(5):387-96. PMID: 24286027; PMCID: PMC3841251.
Brade T, Pane LS, Moretti A, Chien KR, Laugwitz KL. Embryonic heart progenitors and cardiogenesis. Cold Spring Harb Perspect Med. 2013 Oct 01; 3(10):a013847. PMID: 24086063; PMCID: PMC3784811.
Lui KO, Zangi L, Silva EA, Bu L, Sahara M, Li RA, Mooney DJ, Chien KR. Driving vascular endothelial cell fate of human multipotent Isl1+ heart progenitors with VEGF modified mRNA. Cell Res. 2013 Oct; 23(10):1172-86. PMID: 24018375; PMCID: PMC3790234.
Yi BA, Mummery CL, Chien KR. Direct cardiomyocyte reprogramming: a new direction for cardiovascular regenerative medicine. Cold Spring Harb Perspect Med. 2013 Sep 01; 3(9):a014050. PMID: 24003244; PMCID: PMC3753721.
Später D, Abramczuk MK, Buac K, Zangi L, Stachel MW, Clarke J, Sahara M, Ludwig A, Chien KR. A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells. Nat Cell Biol. 2013 Sep; 15(9):1098-106. PMID: 23974038.
Lian X, Chien KR. The years of the monkey. Cell Res. 2013 Oct; 23(10):1161-2. PMID: 23958583; PMCID: PMC3790233.
Chien K. Body, heal thyself. An interview with Kenneth Chien, Professor of Cardiovascular Research at the Department of Cell & Molecular Biology, and the Department of Medicine at Karolinska Institutet in Sweden. Interview by Holger Breithaupt. EMBO Rep. 2013 Sep; 14(9):755-8. PMID: 23938329; PMCID: PMC3790057.
Chien KR. Regenerative biology: heartbroken embryos heal. Nature. 2013 Jun 27; 498(7455):439-40. PMID: 23783518.
Soh BS, Wu H, Chien KR. Cardiac regenerative medicine 2.0. Nat Biotechnol. 2013 Mar; 31(3):209-11. PMID: 23471068.
Hansson EM, Chien KR. Reprogramming a broken heart. Cell Stem Cell. 2012 Jul 06; 11(1):3-4. PMID: 22770235.
Xu H, Yi BA, Chien KR. In vivo reprogramming for heart disease. Cell Res. 2012 Nov; 22(11):1521-3. PMID: 22751090; PMCID: PMC3494388.
Chien KR, Yi BA, Xu H, Mummery CL. Cardiomyocyte reprogramming and the new age of cellular alchemy. J Mol Cell Cardiol. 2012 Sep; 53(3):311-3. PMID: 22749824.
Ptaszek LM, Mansour M, Ruskin JN, Chien KR. Towards regenerative therapy for cardiac disease. Lancet. 2012 Mar 10; 379(9819):933-942. PMID: 22405796.
Chmielowiec J, Chang YS, Chien KR. A GPS for heart progenitor cell lineages. Mol Ther. 2011 Sep; 19(9):1576-8. PMID: 21886115; PMCID: PMC3182357.
Vunjak-Novakovic G, Lui KO, Tandon N, Chien KR. Bioengineering heart muscle: a paradigm for regenerative medicine. Annu Rev Biomed Eng. 2011 Aug 15; 13:245-67. PMID: 21568715; PMCID: PMC3405288.
Knöll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schäfer K, Knöll G, Felkin LE, Wessels J, Toischer K, Hagn F, Kessler H, Didié M, Quentin T, Maier LS, Teucher N, Unsöld B, Schmidt A, Birks EJ, Gunkel S, Lang P, Granzier H, Zimmermann WH, Field LJ, Faulkner G, Dobbelstein M, Barton PJ, Sattler M, Wilmanns M, Chien KR. Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circ Res. 2011 Sep 16; 109(7):758-69. PMID: 21799151; PMCID: PMC3664427.
Xu H, Yi BA, Chien KR. Shortcuts to making cardiomyocytes. Nat Cell Biol. 2011 Mar; 13(3):191-3. PMID: 21364566.
Terada R, Warren S, Lu JT, Chien KR, Wessels A, Kasahara H. Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation. Cardiovasc Res. 2011 Jul 15; 91(2):289-99. PMID: 21285290; PMCID: PMC3125071.
Nakano H, Williams E, Hoshijima M, Sasaki M, Minamisawa S, Chien KR, Nakano A. Cardiac origin of smooth muscle cells in the inflow tract. J Mol Cell Cardiol. 2011 Feb; 50(2):337-45. PMID: 20974149; PMCID: PMC3031779.
Rodin S, Domogatskaya A, Ström S, Hansson EM, Chien KR, Inzunza J, Hovatta O, Tryggvason K. Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511. Nat Biotechnol. 2010 Jun; 28(6):611-5. PMID: 20512123.
Bu L, Gao X, Jiang X, Chien KR, Wang Z. Targeted conditional gene knockout in human embryonic stem cells. Cell Res. 2010 Mar; 20(3):379-82. PMID: 20142843.
Yi BA, Wernet O, Chien KR. Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration. J Clin Invest. 2010 Jan; 120(1):20-8. PMID: 20051633; PMCID: PMC2798699.
Musunuru K, Domian IJ, Chien KR. Stem cell models of cardiac development and disease. Annu Rev Cell Dev Biol. 2010; 26:667-87. PMID: 20604707; PMCID: PMC3955884.
Knöll R, Kostin S, Klede S, Savvatis K, Klinge L, Stehle I, Gunkel S, Kötter S, Babicz K, Sohns M, Miocic S, Didié M, Knöll G, Zimmermann WH, Thelen P, Bickeböller H, Maier LS, Schaper W, Schaper J, Kraft T, Tschöpe C, Linke WA, Chien KR. A common MLP (muscle LIM protein) variant is associated with cardiomyopathy. Circ Res. 2010 Mar 05; 106(4):695-704. PMID: 20044516.
Domian IJ, Chiravuri M, van der Meer P, Feinberg AW, Shi X, Shao Y, Wu SM, Parker KK, Chien KR. Generation of functional ventricular heart muscle from mouse ventricular progenitor cells. Science. 2009 Oct 16; 326(5951):426-9. PMID: 19833966; PMCID: PMC2895998.
Hansson EM, Lindsay ME, Chien KR. Regeneration next: toward heart stem cell therapeutics. Cell Stem Cell. 2009 Oct 02; 5(4):364-77. PMID: 19796617.
Andersson KB, Finsen AV, Sjåland C, Winer LH, Sjaastad I, Odegaard A, Louch WE, Wang Y, Chen J, Chien KR, Sejersted OM, Christensen G. Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models. Cell Calcium. 2009 Sep; 46(3):219-25. PMID: 19692123; PMCID: PMC4313567.
Bu L, Jiang X, Martin-Puig S, Caron L, Zhu S, Shao Y, Roberts DJ, Huang PL, Domian IJ, Chien KR. Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages. Nature. 2009 Jul 02; 460(7251):113-7. PMID: 19571884.
Takeda M, Briggs LE, Wakimoto H, Marks MH, Warren SA, Lu JT, Weinberg EO, Robertson KD, Chien KR, Kasahara H. Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation. Lab Invest. 2009 Sep; 89(9):983-93. PMID: 19546853; PMCID: PMC2733927.
Andersson KB, Birkeland JA, Finsen AV, Louch WE, Sjaastad I, Wang Y, Chen J, Molkentin JD, Chien KR, Sejersted OM, Christensen G. Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene. J Mol Cell Cardiol. 2009 Aug; 47(2):180-7. PMID: 19328205.
Risebro CA, Searles RG, Melville AA, Ehler E, Jina N, Shah S, Pallas J, Hubank M, Dillard M, Harvey NL, Schwartz RJ, Chien KR, Oliver G, Riley PR. Prox1 maintains muscle structure and growth in the developing heart. Development. 2009 Feb; 136(3):495-505. PMID: 19091769; PMCID: PMC2655234.
Chien KR, Domian IJ, Parker KK. Cardiogenesis and the complex biology of regenerative cardiovascular medicine. Science. 2008 Dec 05; 322(5907):1494-7. PMID: 19056974.
Briggs LE, Takeda M, Cuadra AE, Wakimoto H, Marks MH, Walker AJ, Seki T, Oh SP, Lu JT, Sumners C, Raizada MK, Horikoshi N, Weinberg EO, Yasui K, Ikeda Y, Chien KR, Kasahara H. Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects. Circ Res. 2008 Sep 12; 103(6):580-90. PMID: 18689573; PMCID: PMC2590500.
Zhou B, Ma Q, Rajagopal S, Wu SM, Domian I, Rivera-Feliciano J, Jiang D, von Gise A, Ikeda S, Chien KR, Pu WT. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature. 2008 Jul 03; 454(7200):109-13. PMID: 18568026; PMCID: PMC2574791.
Adams JW, Wang J, Davis JR, Liaw C, Gaidarov I, Gatlin J, Dalton ND, Gu Y, Ross J, Behan D, Chien K, Connolly D. Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor. Am J Physiol Heart Circ Physiol. 2008 Aug; 295(2):H509-21. PMID: 18539757.
Geier C, Gehmlich K, Ehler E, Hassfeld S, Perrot A, Hayess K, Cardim N, Wenzel K, Erdmann B, Krackhardt F, Posch MG, Osterziel KJ, Bublak A, Nägele H, Scheffold T, Dietz R, Chien KR, Spuler S, Fürst DO, Nürnberg P, Ozcelik C. Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy. Hum Mol Genet. 2008 Sep 15; 17(18):2753-65. PMID: 18505755.
Chien KR. Regenerative medicine and human models of human disease. Nature. 2008 May 15; 453(7193):302-5. PMID: 18480810.
Martin-Puig S, Wang Z, Chien KR. Lives of a heart cell: tracing the origins of cardiac progenitors. Cell Stem Cell. 2008 Apr 10; 2(4):320-31. PMID: 18397752.
Wu SM, Chien KR, Mummery C. Origins and fates of cardiovascular progenitor cells. Cell. 2008 Feb 22; 132(4):537-43. PMID: 18295570; PMCID: PMC2507768.
Osafune K, Caron L, Borowiak M, Martinez RJ, Fitz-Gerald CS, Sato Y, Cowan CA, Chien KR, Melton DA. Marked differences in differentiation propensity among human embryonic stem cell lines. Nat Biotechnol. 2008 Mar; 26(3):313-5. PMID: 18278034.
Ikeda Y, Hoshijima M, Chien KR. Toward biologically targeted therapy of calcium cycling defects in heart failure. Physiology (Bethesda). 2008 Feb; 23:6-16. PMID: 18268360.
Chan JY, Takeda M, Briggs LE, Graham ML, Lu JT, Horikoshi N, Weinberg EO, Aoki H, Sato N, Chien KR, Kasahara H. Identification of cardiac-specific myosin light chain kinase. Circ Res. 2008 Mar 14; 102(5):571-80. PMID: 18202317; PMCID: PMC2504503.
Laugwitz KL, Moretti A, Caron L, Nakano A, Chien KR. Islet1 cardiovascular progenitors: a single source for heart lineages? Development. 2008 Jan; 135(2):193-205. PMID: 18156162.
Kaye DM, Hoshijima M, Chien KR. Reversing advanced heart failure by targeting Ca2+ cycling. Annu Rev Med. 2008; 59:13-28. PMID: 18186701.
Yamamoto R, Akazawa H, Ito K, Toko H, Sano M, Yasuda N, Qin Y, Kudo Y, Sugaya T, Chien KR, Komuro I. Angiotensin II type 1a receptor signals are involved in the progression of heart failure in MLP-deficient mice. Circ J. 2007 Dec; 71(12):1958-64. PMID: 18037754.
Knöll R, Postel R, Wang J, Krätzner R, Hennecke G, Vacaru AM, Vakeel P, Schubert C, Murthy K, Rana BK, Kube D, Knöll G, Schäfer K, Hayashi T, Holm T, Kimura A, Schork N, Toliat MR, Nürnberg P, Schultheiss HP, Schaper W, Schaper J, Bos E, Den Hertog J, van Eeden FJ, Peters PJ, Hasenfuss G, Chien KR, Bakkers J. Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells. Circulation. 2007 Jul 31; 116(5):515-25. PMID: 17646580.
Kaye DM, Preovolos A, Marshall T, Byrne M, Hoshijima M, Hajjar R, Mariani JA, Pepe S, Chien KR, Power JM. Percutaneous cardiac recirculation-mediated gene transfer of an inhibitory phospholamban peptide reverses advanced heart failure in large animals. J Am Coll Cardiol. 2007 Jul 17; 50(3):253-60. PMID: 17631218.
Hirai M, Horiguchi M, Ohbayashi T, Kita T, Chien KR, Nakamura T. Latent TGF-beta-binding protein 2 binds to DANCE/fibulin-5 and regulates elastic fiber assembly. EMBO J. 2007 Jul 25; 26(14):3283-95. PMID: 17581631; PMCID: PMC1933399.
Qyang Y, Martin-Puig S, Chiravuri M, Chen S, Xu H, Bu L, Jiang X, Lin L, Granger A, Moretti A, Caron L, Wu X, Clarke J, Taketo MM, Laugwitz KL, Moon RT, Gruber P, Evans SM, Ding S, Chien KR. The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell. 2007 Aug 16; 1(2):165-79. PMID: 18371348.
Chien KR. Molecular medicine: microRNAs and the tell-tale heart. Nature. 2007 May 24; 447(7143):389-90. PMID: 17522664.
Smart N, Risebro CA, Melville AA, Moses K, Schwartz RJ, Chien KR, Riley PR. Thymosin beta-4 is essential for coronary vessel development and promotes neovascularization via adult epicardium. Ann N Y Acad Sci. 2007 Sep; 1112:171-88. PMID: 17495252.
Hirai M, Ohbayashi T, Horiguchi M, Okawa K, Hagiwara A, Chien KR, Kita T, Nakamura T. Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo. J Cell Biol. 2007 Mar 26; 176(7):1061-71. PMID: 17371835; PMCID: PMC2064089.
Prall OW, Menon MK, Solloway MJ, Watanabe Y, Zaffran S, Bajolle F, Biben C, McBride JJ, Robertson BR, Chaulet H, Stennard FA, Wise N, Schaft D, Wolstein O, Furtado MB, Shiratori H, Chien KR, Hamada H, Black BL, Saga Y, Robertson EJ, Buckingham ME, Harvey RP. An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell. 2007 Mar 09; 128(5):947-59. PMID: 17350578.
Pomiès P, Pashmforoush M, Vegezzi C, Chien KR, Auffray C, Beckerle MC. The cytoskeleton-associated PDZ-LIM protein, ALP, acts on serum response factor activity to regulate muscle differentiation. Mol Biol Cell. 2007 May; 18(5):1723-33. PMID: 17332502.
Muller O, Pradervand S, Berger S, Centeno G, Milet A, Nicod P, Pedrazzini T, Tronche F, Schütz G, Chien K, Rossier BC, Firsov D. Identification of corticosteroid-regulated genes in cardiomyocytes by serial analysis of gene expression. Genomics. 2007 Mar; 89(3):370-7. PMID: 17174066.
Teutsch C, Kondo RP, Dederko DA, Chrast J, Chien KR, Giles WR. Spatial distributions of Kv4 channels and KChip2 isoforms in the murine heart based on laser capture microdissection. Cardiovasc Res. 2007 Mar 01; 73(4):739-49. PMID: 17289005.
Moretti A, Caron L, Nakano A, Lam JT, Bernshausen A, Chen Y, Qyang Y, Bu L, Sasaki M, Martin-Puig S, Sun Y, Evans SM, Laugwitz KL, Chien KR. Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell. 2006 Dec 15; 127(6):1151-65. PMID: 17123592.
Smart N, Risebro CA, Melville AA, Moses K, Schwartz RJ, Chien KR, Riley PR. Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature. 2007 Jan 11; 445(7124):177-82. PMID: 17108969.
Yajima T, Yasukawa H, Jeon ES, Xiong D, Dorner A, Iwatate M, Nara M, Zhou H, Summers-Torres D, Hoshijima M, Chien KR, Yoshimura A, Knowlton KU. Innate defense mechanism against virus infection within the cardiac myocyte requiring gp130-STAT3 signaling. Circulation. 2006 Nov 28; 114(22):2364-73. PMID: 17101849.
Hoshijima M, Knöll R, Pashmforoush M, Chien KR. Reversal of calcium cycling defects in advanced heart failure toward molecular therapy. J Am Coll Cardiol. 2006 Nov 07; 48(9 Suppl 1):A15-23. PMID: 17084280.
Weissgerber P, Held B, Bloch W, Kaestner L, Chien KR, Fleischmann BK, Lipp P, Flockerzi V, Freichel M. Reduced cardiac L-type Ca2+ current in Ca(V)beta2-/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation. Circ Res. 2006 Sep 29; 99(7):749-57. PMID: 16946137.
Ricote M, Snyder CS, Leung HY, Chen J, Chien KR, Glass CK. Normal hematopoiesis after conditional targeting of RXRalpha in murine hematopoietic stem/progenitor cells. J Leukoc Biol. 2006 Oct; 80(4):850-61. PMID: 16888087.
Chien KR. Lost and found: cardiac stem cell therapy revisited. J Clin Invest. 2006 Jul; 116(7):1838-40. PMID: 16823485; PMCID: PMC1483159.
Chien KR. Herceptin and the heart--a molecular modifier of cardiac failure. N Engl J Med. 2006 Feb 23; 354(8):789-90. PMID: 16495390.
Chien KR. Beyond small molecule drugs for heart failure: prospects for gene therapy. Novartis Found Symp. 2006; 274:244-56; discussion 256-9, 272-6. PMID: 17019816.
Peng X, Kraus MS, Wei H, Shen TL, Pariaut R, Alcaraz A, Ji G, Cheng L, Yang Q, Kotlikoff MI, Chen J, Chien K, Gu H, Guan JL. Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice. J Clin Invest. 2006 Jan; 116(1):217-27. PMID: 16374517; PMCID: PMC1319217.
Kondo RP, Dederko DA, Teutsch C, Chrast J, Catalucci D, Chien KR, Giles WR. Comparison of contraction and calcium handling between right and left ventricular myocytes from adult mouse heart: a role for repolarization waveform. J Physiol. 2006 Feb 15; 571(Pt 1):131-46. PMID: 16357014; PMCID: PMC1805641.
Merki E, Zamora M, Raya A, Kawakami Y, Wang J, Zhang X, Burch J, Kubalak SW, Kaliman P, Izpisua Belmonte JC, Chien KR, Ruiz-Lozano P. Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18455-60. PMID: 16352730; PMCID: PMC1317903.
Wang J, Hoshijima M, Lam J, Zhou Z, Jokiel A, Dalton ND, Hultenby K, Ruiz-Lozano P, Ross J, Tryggvason K, Chien KR. Cardiomyopathy associated with microcirculation dysfunction in laminin alpha4 chain-deficient mice. J Biol Chem. 2006 Jan 06; 281(1):213-20. PMID: 16204254.
Lorenzen-Schmidt I, Stuyvers BD, ter Keurs HE, Date MO, Hoshijima M, Chien KR, McCulloch AD, Omens JH. Young MLP deficient mice show diastolic dysfunction before the onset of dilated cardiomyopathy. J Mol Cell Cardiol. 2005 Aug; 39(2):241-50. PMID: 15978612; PMCID: PMC4484861.
Chien KR. Alchemy and the new age of cardiac muscle cell biology. PLoS Biol. 2005 Apr; 3(4):e131. PMID: 15819607; PMCID: PMC1074813.
Chien KR, Karsenty G. Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle, and bone. Cell. 2005 Feb 25; 120(4):533-44. PMID: 15734685.
Laugwitz KL, Moretti A, Lam J, Gruber P, Chen Y, Woodard S, Lin LZ, Cai CL, Lu MM, Reth M, Platoshyn O, Yuan JX, Evans S, Chien KR. Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature. 2005 Feb 10; 433(7026):647-53. PMID: 15703750.
Minamisawa S, Oshikawa J, Takeshima H, Hoshijima M, Wang Y, Chien KR, Ishikawa Y, Matsuoka R. Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies. Biochem Biophys Res Commun. 2004 Dec 17; 325(3):852-6. PMID: 15541368.
Kaliman P, Catalucci D, Lam JT, Kondo R, Gutiérrez JC, Reddy S, Palacín M, Zorzano A, Chien KR, Ruiz-Lozano P. Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum. J Biol Chem. 2005 Mar 04; 280(9):8016-21. PMID: 15598648.
Hayashi T, Arimura T, Itoh-Satoh M, Ueda K, Hohda S, Inagaki N, Takahashi M, Hori H, Yasunami M, Nishi H, Koga Y, Nakamura H, Matsuzaki M, Choi BY, Bae SW, You CW, Han KH, Park JE, Knöll R, Hoshijima M, Chien KR, Kimura A. Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy. J Am Coll Cardiol. 2004 Dec 07; 44(11):2192-201. PMID: 15582318.
Nishida K, Yamaguchi O, Hirotani S, Hikoso S, Higuchi Y, Watanabe T, Takeda T, Osuka S, Morita T, Kondoh G, Uno Y, Kashiwase K, Taniike M, Nakai A, Matsumura Y, Miyazaki J, Sudo T, Hongo K, Kusakari Y, Kurihara S, Chien KR, Takeda J, Hori M, Otsu K. p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload. Mol Cell Biol. 2004 Dec; 24(24):10611-20. PMID: 15572667; PMCID: PMC533965.
Conrad M, Jakupoglu C, Moreno SG, Lippl S, Banjac A, Schneider M, Beck H, Hatzopoulos AK, Just U, Sinowatz F, Schmahl W, Chien KR, Wurst W, Bornkamm GW, Brielmeier M. Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. Mol Cell Biol. 2004 Nov; 24(21):9414-23. PMID: 15485910; PMCID: PMC522221.
Pradervand S, Yasukawa H, Muller OG, Kjekshus H, Nakamura T, St Amand TR, Yajima T, Matsumura K, Duplain H, Iwatate M, Woodard S, Pedrazzini T, Ross J, Firsov D, Rossier BC, Hoshijima M, Chien KR. Small proline-rich protein 1A is a gp130 pathway- and stress-inducible cardioprotective protein. EMBO J. 2004 Nov 10; 23(22):4517-25. PMID: 15510217; PMCID: PMC526469.
Chien KR, Moretti A, Laugwitz KL. Development. ES cells to the rescue. Science. 2004 Oct 08; 306(5694):239-40. PMID: 15472069.
Yamaguchi O, Watanabe T, Nishida K, Kashiwase K, Higuchi Y, Takeda T, Hikoso S, Hirotani S, Asahi M, Taniike M, Nakai A, Tsujimoto I, Matsumura Y, Miyazaki J, Chien KR, Matsuzawa A, Sadamitsu C, Ichijo H, Baccarini M, Hori M, Otsu K. Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. J Clin Invest. 2004 Oct; 114(7):937-43. PMID: 15467832; PMCID: PMC518660.
Smith RM, Suleman N, Lacerda L, Opie LH, Akira S, Chien KR, Sack MN. Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning. Cardiovasc Res. 2004 Sep 01; 63(4):611-6. PMID: 15306216.
Chien KR, Hoshijima M. Unravelling Ras signals in cardiovascular disease. Nat Cell Biol. 2004 Sep; 6(9):807-8. PMID: 15340447.
Carrier L, Knöll R, Vignier N, Keller DI, Bausero P, Prudhon B, Isnard R, Ambroisine ML, Fiszman M, Ross J, Schwartz K, Chien KR. Asymmetric septal hypertrophy in heterozygous cMyBP-C null mice. Cardiovasc Res. 2004 Aug 01; 63(2):293-304. PMID: 15249187.
Mori H, Hanada R, Hanada T, Aki D, Mashima R, Nishinakamura H, Torisu T, Chien KR, Yasukawa H, Yoshimura A. Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat Med. 2004 Jul; 10(7):739-43. PMID: 15208705.
Pashmforoush M, Lu JT, Chen H, Amand TS, Kondo R, Pradervand S, Evans SM, Clark B, Feramisco JR, Giles W, Ho SY, Benson DW, Silberbach M, Shou W, Chien KR. Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block. Cell. 2004 Apr 30; 117(3):373-86. PMID: 15109497.
Chien KR. Stem cells: lost in translation. Nature. 2004 Apr 08; 428(6983):607-8. PMID: 15034595.
Chen H, Shi S, Acosta L, Li W, Lu J, Bao S, Chen Z, Yang Z, Schneider MD, Chien KR, Conway SJ, Yoder MC, Haneline LS, Franco D, Shou W. BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development. 2004 May; 131(9):2219-31. PMID: 15073151; PMCID: PMC2628765.
Chien K, Chien L. The new Silk Road. Nature. 2004 Mar 11; 428(6979):208-9. PMID: 15014508.
Bale TL, Hoshijima M, Gu Y, Dalton N, Anderson KR, Lee KF, Rivier J, Chien KR, Vale WW, Peterson KL. The cardiovascular physiologic actions of urocortin II: acute effects in murine heart failure. Proc Natl Acad Sci U S A. 2004 Mar 09; 101(10):3697-702. PMID: 14990799; PMCID: PMC373525.
Kimura A, Kinjyo I, Matsumura Y, Mori H, Mashima R, Harada M, Chien KR, Yasukawa H, Yoshimura A. SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling. J Biol Chem. 2004 Feb 20; 279(8):6905-10. PMID: 14699146.
Knöll R, Hoshijima M, Chien K. Cardiac mechanotransduction and implications for heart disease. J Mol Med (Berl). 2003 Dec; 81(12):750-6. PMID: 14551702.
Zheng M, Dilly K, Dos Santos Cruz J, Li M, Gu Y, Ursitti JA, Chen J, Ross J, Chien KR, Lederer JW, Wang Y. Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart. Am J Physiol Heart Circ Physiol. 2004 Jan; 286(1):H424-33. PMID: 12969887.
Yasukawa H, Ohishi M, Mori H, Murakami M, Chinen T, Aki D, Hanada T, Takeda K, Akira S, Hoshijima M, Hirano T, Chien KR, Yoshimura A. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol. 2003 Jun; 4(6):551-6. PMID: 12754507.
Chien KR, Ross J, Hoshijima M. Calcium and heart failure: the cycle game. Nat Med. 2003 May; 9(5):508-9. PMID: 12724757.
Minamisawa S, Wang Y, Chen J, Ishikawa Y, Chien KR, Matsuoka R. Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling. J Biol Chem. 2003 Mar 14; 278(11):9570-5. PMID: 12645548.
Gopalan SM, Flaim C, Bhatia SN, Hoshijima M, Knoell R, Chien KR, Omens JH, McCulloch AD. Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers. Biotechnol Bioeng. 2003 Mar 05; 81(5):578-87. PMID: 12514807.
Yasukawa H, Yajima T, Duplain H, Iwatate M, Kido M, Hoshijima M, Weitzman MD, Nakamura T, Woodard S, Xiong D, Yoshimura A, Chien KR, Knowlton KU. The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury. J Clin Invest. 2003 Feb; 111(4):469-78. PMID: 12588885; PMCID: PMC151924.
Cheng CF, Kuo HC, Chien KR. Genetic modifiers of cardiac arrhythmias. Trends Mol Med. 2003 Feb; 9(2):59-66. PMID: 12615039.
Ludwig A, Budde T, Stieber J, Moosmang S, Wahl C, Holthoff K, Langebartels A, Wotjak C, Munsch T, Zong X, Feil S, Feil R, Lancel M, Chien KR, Konnerth A, Pape HC, Biel M, Hofmann F. Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2. EMBO J. 2003 Jan 15; 22(2):216-24. PMID: 12514127; PMCID: PMC140107.
St Amand TR, Lu JT, Chien KR. Defects in cardiac conduction system lineages and malignant arrhythmias: developmental pathways and disease. Novartis Found Symp. 2003; 250:260-70; discussion 271-5, 276-9. PMID: 12956335.
Christensen G, Gruber PJ, Wang Y, Chien KR. Embryonic and neonatal cardiac gene transfer in vivo. Methods Mol Biol. 2003; 219:169-78. PMID: 12597007.
Chien KR. Genotype, phenotype: upstairs, downstairs in the family of cardiomyopathies. J Clin Invest. 2003 Jan; 111(2):175-8. PMID: 12531871; PMCID: PMC151886.
Ruiz-Lozano P, Chien KR. Cre-constructing the heart. Nat Genet. 2003 Jan; 33(1):8-9. PMID: 12509773.
Knöll R, Hoshijima M, Hoffman HM, Person V, Lorenzen-Schmidt I, Bang ML, Hayashi T, Shiga N, Yasukawa H, Schaper W, McKenna W, Yokoyama M, Schork NJ, Omens JH, McCulloch AD, Kimura A, Gregorio CC, Poller W, Schaper J, Schultheiss HP, Chien KR. The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell. 2002 Dec 27; 111(7):943-55. PMID: 12507422.
Hamblet NS, Lijam N, Ruiz-Lozano P, Wang J, Yang Y, Luo Z, Mei L, Chien KR, Sussman DJ, Wynshaw-Boris A. Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development. 2002 Dec; 129(24):5827-38. PMID: 12421720.
Jiang X, Choudhary B, Merki E, Chien KR, Maxson RE, Sucov HM. Normal fate and altered function of the cardiac neural crest cell lineage in retinoic acid receptor mutant embryos. Mech Dev. 2002 Sep; 117(1-2):115-22. PMID: 12204252.
Chien KR, Olson EN. Converging pathways and principles in heart development and disease: CV@CSH. Cell. 2002 Jul 26; 110(2):153-62. PMID: 12150924.
Ozcelik C, Erdmann B, Pilz B, Wettschureck N, Britsch S, Hübner N, Chien KR, Birchmeier C, Garratt AN. Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8880-5. PMID: 12072561; PMCID: PMC124392.
Ferrer-Martínez A, Ruiz-Lozano P, Chien KR. Mouse PeP: a novel peroxisomal protein linked to myoblast differentiation and development. Dev Dyn. 2002 Jun; 224(2):154-67. PMID: 12112469.
Crone SA, Zhao YY, Fan L, Gu Y, Minamisawa S, Liu Y, Peterson KL, Chen J, Kahn R, Condorelli G, Ross J, Chien KR, Lee KF. ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med. 2002 May; 8(5):459-65. PMID: 11984589.
Hoshijima M, Chien KR. Mixed signals in heart failure: cancer rules. J Clin Invest. 2002 Apr; 109(7):849-55. PMID: 11927610; PMCID: PMC150934.
Nakamura T, Lozano PR, Ikeda Y, Iwanaga Y, Hinek A, Minamisawa S, Cheng CF, Kobuke K, Dalton N, Takada Y, Tashiro K, Ross J, Honjo T, Chien KR. Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature. 2002 01 10; 415(6868):171-5. PMID: 11805835.
Knöll R, Hoshijima M, Chien KR. Muscle LIM protein in heart failure. Exp Clin Cardiol. 2002; 7(2-3):104-5. PMID: 19649232; PMCID: PMC2719181.
Chien KR. Something old, something new, something borrowed, something blue: notes on TCM ten years after. Trends Cardiovasc Med. 2002 Jan; 12(1):1-2. PMID: 11796236.


Belfast Zoo is one of the top visitor attractions and one of the oldest in Northern Ireland, with a quarter of a million visitors each year. Located in North Belfast on the slopes of Cave Hill, the zoo has more than 1,000 animals and 150 species, many of which are in danger in their natural habitat. The zoo undergoes significant conservation work and international breeding programmes which ensure the survival of many species that are under threat.
The zoo covers 55-acre ground with an upward slope so make sure to wear comfortable shoes. It is easy to spend the whole day to cover the whole area so you can bring your own food for some picnic or eat at their restaurant or tea room on-site.
Giraffe and Elephant Enclosure – home to large herds of Rothchild's giraffes with the recent addition of a new calf, born just this month of April. There are other animals sharing this enclosure such as meerkats, Visayan warty pigs, cape porcupines, capybaras and giant anteaters.
Rainforest House – a walk-through display with tropical landscaping. They feature various animals inside the house which include bats, doves and several species of pigeons.
Lake Side – home to animals like great white pelicans, Colombian spider monkeys, and Chilean flamingos. They also have picnic tables, a farm and a new play facility for the kids.


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November 2007 - Baltimore Orioles Wiretap
Orioles, Bedard Stall On Contract
Contract extension talks between the Orioles and Erik Bedard stalled yesterday, increasing the likelihood that team officials will spend part of next week's winter meetings contemplating trade offers for the ace left-hander. "We've had some conversations. We spoke again today, but I'd say that we've cooled in that area," Orioles' President of Baseball Operations Andy MacPhail said of the negotiations with Bedard's agent Mark Pieper. "We've gone on to other things. It doesn't mean that [negotiations] can't or won't be started again. It just means that they've cooled for now." MacPhail said he didn't consider the development a huge setback in the club's effort to sign a long-term deal with Bedard, who isn't eligible for free agency until after the 2009 season. He also didn't rule out the talks resuming, though none are expected to take place at the winter meetings.
Tags: Baltimore Orioles, Free Agent Rumor
Cardinals Trying To Trade For Tejada
Three days away from formally extending or rejecting arbitration to former World Series' MVP David Eckstein, the Cardinals continue to explore alternatives that include the Baltimore Orioles' Miguel Tejada, the Pittsburgh Pirates' Jack Wilson and free agent Cesar Izturis. Tejada, the 2002 American League MVP, is considered one of the marquee names most likely to be dealt this winter, possibly at next week's winter meetings in Nashville, Tenn. But any pursuit comes with strings attached. Also reportedly coveted by the Los Angeles Angels, Tejada is unlikely to move before Saturday, when clubs must either offer or reject arbitration to their own free agents.
Tags: Baltimore Orioles, St. Louis Cardinals, Trade Rumor
Mets Made Strong Run For Bedard
The Mets made a strong run at Orioles' left-hander Erik Bedard at the General Managers' meetings, but at the time Orioles' President of Baseball Operations Andy MacPhail was not ready to make a move. MacPhail reportedly gave a similar response to a recent inquiry on Bedard by the Dodgers, but he could jump once he concludes that he can't sign the pitcher long-term. A package of youngsters headed by the Mets' Carlos Gomez or Dodgers' Matt Kemp would be enticing.
Tags: Baltimore Orioles, New York Mets, Trade Rumor
No Recent Talks Between Angels And Orioles On Tejada
An industry source said Monday that the Orioles and Angels have not had any significant discussions recently about Miguel Tejada, who is expected to be traded this offseason. However, another league source said the Angels would be interested in Tejada to potentially play third base if the club can't make a trade for Florida Marlins' slugger Miguel Cabrera. Orioles' President of Baseball Operations Andy MacPhail wouldn't comment on any specific talks, though he said he's in daily contact with several teams as the winter meetings draw closer. They will be held the first week in December in Nashville, Tenn. "A day doesn't go by where you don't talk to at least three or four clubs," MacPhail said. "I would hope we'd be able to do some things. Right now, my best guess would be at Nashville. But we wouldn't hesitate to do some things earlier if it makes sense for us." The Orioles nearly traded Tejada to the Angels before the trade deadline during the 2006 season. However, a potential deal that would have sent Tejada to the Angels for infield prospect Erick Aybar and pitcher Ervin Santana was scrapped when the Orioles insisted on getting a third player in return.
Tags: Baltimore Orioles, Los Angeles Angels of Anaheim, Trade Rumor
O's Would Like To Extend Bedard
For all the temptation to trade Erik Bedard, there may yet be an even greater pull for the Orioles to keep him. Orioles' President of Baseball Operations Andy MacPhail won't trade Bedard without first determining what it would take to sign him to a contract extension, according to a report published on Thursday in the Baltimore Sun. MacPhail is set to begin conversations with Bedard's agent before next month's Winter Meetings begin. "Young left-handed starters don't grow on trees," MacPhail told the Sun. "Especially ones that are potentially dominant as Erik has been." Bedard, 28, finished the 2007 season with a 13-5 record, a 3.16 ERA and 221 strikeouts despite missing an entire month with a strained right oblique. His current contract runs through 2009, and an extension would require the Orioles to offer significantly more money per year than the $3.4 million Bedard made in 2007.
Tags: Baltimore Orioles, Free Agent Rumor, Misc Rumor
Dodgers Really Like Bedard
The Dodgers, who have a well-stocked farm system, have been one of the most aggressive suitors for Erik Bedard, according to a team source. Among the players that have been discussed, the source said, are Matt Kemp, a 23-year-old outfielder; Jonathan Broxton, a 23-year-old reliever; and Clayton Kershaw, a 19-year-old left-handed starter who is regarded as one of the top prospects in baseball. However, those three players reportedly also are being mentioned in trade talks between the Dodgers and Florida Marlins involving the latter's starting third baseman, Miguel Cabrera. If they decide to trade Bedard, the Orioles likely will look for three young major league-ready players in return.
Tags: Baltimore Orioles, Los Angeles Dodgers, Trade Rumor
Mets Express Interest In Baltimore's Hernandez
The New York Mets expressed interest in Orioles' catcher Ramon Hernandez. However, the Orioles' asking price - a high-end prospect - was more than what the Mets were willing to give up, according to an industry source. The Mets reportedly are close to signing free-agent catcher Yorvit Torrealba.
Orioles Angry Over Huff's Radio Comments
The Orioles are considering disciplining Aubrey Huff for comments he made during a recent radio appearance, the Baltimore Sun reported on its web site Thursday. Huff appeared on satellite radio's "Bubba The Love Sponge" show on November 8 and, during the 90-minute spot, referred to Baltimore as a "horse (expletive) city" in addition to discussing other racy topics. Team officials reportedly are furious with Huff, who signed a three-year, $20 million deal with the Orioles in January.
Orioles Prez: Yankees Have Plenty Of Minor League Talent Beyond Big 3
Nov 9, 2007 2:42 PM
Baltimore president Andy MacPhail told the New York Daily News on Thursday that he thinks the Yankees have plenty of minor league talent beyond the three starters that every other team is trying to pry away from Brian Cashman. The Orioles are one of the few teams that won't demand Joba Chamberlain, Phil Hughes or Ian Kennedy from the Yankees for a player like Miguel Tejada.
Tags: Baltimore Orioles, New York Yankees, Trade Rumor
Source: Yankees Interested In Tejada
Seeking a potential replacement for free agent third baseman Alex Rodriguez, the New York Yankees have some interest in the Orioles' star infielder, according to an industry source. How much interest they have, and how willing the Orioles will be to trade their most accomplished player to a division rival remains to be seen. One reason the Orioles balked at trading Tejada to the Boston Red Sox after the 2005 season was that some in the organization, including owner Peter Angelos, were hesitant to help a division rival. "We have to be open-minded to anything," Orioles' President Andy MacPhail said, talking in general about the potential of moving Tejada. "If we think a deal at the end of the day makes sense for us, we're going to do it."
Not Much Interest In Tejada
Orioles Name Dave Jauss Bench Coach
Orioles Cut Ties With Kris Benson

redpajama_set_name: RedPajamaCommonCrawl


If you've been too busy holding down a job (or two), juggling the demands of a busy family, engaging in community service and occasionally taking the wife and children out for a pizza on a Saturday night, you may not have noticed that several thousand protesters have "occupied" Wall Street, the District and other locations across the United States for the past three weeks or so.
They're protesting — well — they're not entirely sure what they're protesting, but they feel strongly about it. Those involved in "the movement" consider themselves part of "the 99 percent" of people who don't have the financial resources or political connections of the so-called "1 percent," and thus they have taken to the streets.
They apparently aren't as bugged by the fact that the "1 percent" is paying the largest chunk of income tax, and of the "99 percent," only about 49 percent pays any tax at all. In fact, most of the folks protesting are young people – predominantly students — who wouldn't know how to address an envelope to the IRS, much less write a paper check to include with a tax return. But someday they'll have to repay their student loans, and they're already pretty steamed about that.
Loosely organized as it is, Occupy Wall Street does have a website, occupywallst.org, which includes a list of 13 "demands" that would fulfill "the movement's" vision of a just society. This is a socialist wish list so thorough and overarching, it lacks only a chicken in every pot and a unicorn in every four-car garage.
Demand 13: All unions, all the time.
Well, there you have it. This is what it looks like when thousands of young people take to the streets of America, spouting off all those great civics lessons and American political theory they learned in our public schools, not to mention displaying their terrific command of free market economics.
Personally, I can't comprehend this list. It's all Greek to me.


All my works are first drafts. I'm Nigerian-American. I'm obsessed with podcasts. I unabashedly shed a thug tear– or two– over the release of any remastered, classic video game on a new console.
"The baby! Did you keep it?" he asked with distaste laced with horror.
"You naughty... naughty woman," he chuckled, snapping the side of her lacy black thong against her waist. "You wore this just for me?"
His lick of a smile vanished, and my fear grew tenfold in my stomach when I heard, "You. My office. Noon sharp."
I asked if she could ever love like that again, and she said, "Never again will I give my heart away." But at this moment, as I looked at her, her words didn't seem to hold true.
Dry lips trembled at the site of the bleeding holes near the heart of his victim, and his victim was still standing. "You should be dead," the shooter whispered in fear.
"Why aren't you getting onto Sophie? She doesn't have her glasses on today either!" Jenna snapped. Shrewdly, Cameron confessed, "Because, unlike you, she actually looks cute without them."
Buddy was still the best gift Travis had given to her, and it saddened her heart to know that he did not want to be a part of his son's life.


AK AIRE LLC Heating & Cooling is a newly established Fully Insured and Bonded Company with a New Jersey Licensed MASTER HVACR on staff providing industry best HVAC repair, maintenance and new installation services. Located in South River, NJ 08882 "The home of the South River Rams" just around the corner from East Brunswick, and a short ride to Rutgers! When we started our company AK AIRE, LLC in 2013, we had one goal in mind... to be able to provide local area families, their homes and also all types of local businesses with complete comfort climate control solutions that fit not only their desired lifestyle, but their pocketbook while also lowering their constant rising utility bills!
We offer expert installation and maintenance by our highly skilled team of factory-trained professional certified technicians back by NATE CERTIFIED for all of Middlesex, Monmouth, Ocean and Somerset Counties in New Jersey and especially all New Jersey Shore coastal town areas including Brick, Forked River, Howell, Jackson, Toms River and more!
AK AIRE, LLC Heating & Cooling, prides ourself with superior skills in heating and air conditioning, we offer our customers a unique perspective in understanding your home's energy needs. We are determined to provide homeowners and businesses alike with our OUTSTANDING SERVICES from heating start ups to finding the freon leak. We repair all make and models of home comfort systems, like Heat Pumps, Boilers, Furnaces, Air Handlers, Condensers, just to name a few. As a Carrier, Rheem and Goodman Dealer, we stock readily available parts and equipment, from thermostats to zoning parts, all of your HVAC solutions are just minutes away!
We offer other services too. For starters, we can provide you with an detail assessment on your home's energy performance, any health and safety issues, while providing you a level of comfort knowing your home is in good hands. With our Service and Maintenance Agreements in place, we have the ability to catch any potential issues that may arise, so that when it is boiling hot or freezing cold your unit is doing what it supposed to do...WORK! For our Business owners we offer our BusinessCare Maintenance Program designed to keep your office running smoothly and your employees working at their best.
So, whether you need routine equipment maintenance, emergency repair, replacement equipment, parts, oil/electric to gas conversions installed in New Jersey Natural Gas (NJNG) & Public Service Gas & Electric (PSEG) areas, give us a call!. If you are interested in a complete high efficiency natural gas, propane heating unit, central air conditioning cooling system or heat pump system, feel free to contact our friendly & courteous sales & service office today.
We are committed to providing you, the customer, with an insightful sales representative, a qualified install crew and knowledgeable service technicians for all your equipment needs.
Welcome to the Right Way, YOUR WAY... AK AIRE, We Make Everything A'oK!!
Here are some key people to get to know!
We Make Everything A' oK!
Welcome to The Right Way, YOUR WAY!
Alan Borusovic started his journey in this Industry nearly 20 years ago upon his graduation from East Brunswick Vocational and Technical School in 1995. He knew then, success comes with hard work, determination and continuingly furthering his education. That same year he enrolled in Lincoln Technical institute located in Union NJ where he specialized in the Heating, Air Conditioning and Ventilation (HVAC) Program. Since then, Alan continued his educational training within the industry, by holding many certifications, including Nate Certification, Building Performance Institute (BPI) Certification and NJ MASTER HVACR Contractor licenses.
Kelley Borusovic is a professional who specializes in customer communication and marketing design. She is a member of NJ Notary Republic and when she has time, offers her services as substitute teacher/paraprofessional, as well as offering her services as a Level 1 Catchiest for her local church. As the owner of AK AIRE, Kelley blogs about HVAC products, marketing, and social media advice for customers seeking help when it comes their home comfort. She manages her service and installation crews, as well as the internal structure of the office.
Lauralee Alfrey is a receptionist who specializes in customer relations/communication which stems from her experience as an independent sales consult for Thirty-one Gift. After 17 years as a Floral Designer, she decided to join the ranks at AK AIRE, for a change in pace. Being new to this industry, Lauralee makes every day a learning experience and continues to offer a unique creative ability to our growing staff.


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2021-22 MLB Free Agency: Where will the best starting pitchers land?
Max Scherzer. Clayton Kershaw. Kevin Gausman. In 2021-22 MLB free-agency, there is no shortage of talent in the pitching game. Championships will be
Clayton Kershaw 'will always have a spot' with Los Angeles Dodgers, Andrew Friedman says
Clayton Kershaw is entering the final stage of his career. Here are some highlights from his most memorable moments. (1:35). CARLSBAD (Calif.) --
LHP Andrew Heaney headed to Los Angeles Dodgers on 1-year deal, source says
Sources confirmed that the Los Angeles Dodgers signed Andrew Heaney to an $8.5 million contract on Monday. Heaney, a left-handed starter aged 30
The Dodgers probably could have paid Clayton Kershaw
Over the weekend, it was qualifying-offer week for MLB teams. Perhaps Clayton Kershaw, the greatest pitcher of his generation, is the only one to
Los Angeles Dodgers offer qualifying offers to Corey Seager, Chris Taylor, but not Clayton Kershaw
NEW YORK -- The Los Angeles Dodgers extended qualifying offers to Chris Taylor and Corey Seager, free agent All-Stars, but not Clayton Kershaw.
Los Angeles Dodgers' Albert Pujols to play in Dominican Republic, not ready to retire from MLB
Check out these top moments from Albert Pujols' storied baseball career, which includes his legendary start with the Cardinals as well as his time
The Dodgers blew it
Don't let Los Angeles Dodgers get away with it. They failed. They failed. They were supposed to start the World Series against the Houston Astros on
We're not even getting the best teams in this year's World Series
The World Series will feature the fourth and 12th best teams in baseball. Atlanta won its first pennant for 22 years on Saturday night with a 4-2
How the Atlanta Braves stunned baseball to reach the World Series
In the bottom of the fourth, Eddie Rosario hits a huge three-run homer to right field to give the Braves an impressive 4-1 lead over Dodgers.
Atlanta Braves back in World Series for first time since 1999 after upsetting Dodgers in NLCS
To win the World Series, the Braves defeated the Dodgers 4-2. (1:25). ATLANTA -- The Atlanta Braves will be returning to the World Series for the


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Pitoresco é um conceito da Estética que faz referência às impressões subjetivas desencadeadas pela contemplação de uma cena paisagística em relação à pintura. Surgiu como um intermediário entre as idéias do Sublime e do Belo, durante o desenvolvimento do Romantismo. A palavra deriva do italiano pittoresco, "semelhante ou feito como uma pintura".

A expressão alla pittoresca no Maneirismo tinha uma acepção literal, e significava algo feito à maneira da pintura, como é usada por Vasari. No século seguinte Marco Boschini a usou para descrever o estilo de pincelada da escola veneziana de pintura. Pitoresco só começou a ser usado como uma descrição de uma qualidade estética específica na Inglaterra do início do século XVIII, quando Joseph Addison em Pleasures of the Imagination, 1712, distinguiu três qualidades estéticas principais: beleza, grandeza (sublimidade) e singularidade (pitoresco). Edmund Burke descreveu a pintura de Claude Lorrain e Nicolas Poussin como pitoresca. Pouco mais tarde William Gilpin propôs a observação da paisagem natural através das regras da composição pictórica, e se tornou uma moda grupos de turistas viajarem pelo interior munidos de um aparato visual que enquadrava a paisagem à guisa de uma pintura. Uvedale Price por fim definiu Pitoresco como uma qualidade intermediária entre o conceito de Sublime e o do Belo, e disse que essa qualidade era enfatizada quando na paisagem apareciam elementos como a rusticidade, a irregularidade e a variedade, com velhas casas, ruínas da antiguidade e árvores frondosas com aspecto secular.

Logo o conceito repercutiu de volta sobre a pintura romântica, que buscou retratar paisagens com essas características, e se tornou importante na evolução da arte do paisagismo inglês, dando origem à criação de jardins que combinavam aspectos formais e outros informais e exóticos, com bosques, prados, pagodes, riachos e grutas artificiais ou simulações de ruínas antigas. No século XIX Richard Payne Knight negou a existência do pitoresco, e disse que ele só existia na mente do observador, que via a paisagem através de sua educação cultural e transferia para ela conceitos artísticos.

Referências

Ver também
Romantismo
Grand Tour
Pintura do romantismo
Jardim inglês

Ligações externas
John Macarthur The Picturesque: architecture, disgust and other irregularities
George P. Landow, "Ruskin on the Picturesque"
"Turner's journeys of the imagination"
Landscape Style of Repton, Price and Knight
Pictures and Poetry. Debunking the Bunk: An Examination of Picturesque Influence, by Keith Waddington. A Masters Thesis at Concordia University.

Romantismo
Estética

redpajama_set_name: RedPajamaWikipedia


Application Description: Construction of an on slab two storey single family dwelling with a secondary suite and an attached double garage.
Revision June 4, 2013 lower deck size altered.
Revision: July 16, 2013--Changed location of furnace, moved and changed window size and closet openings changed.


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Exhibition // Pronouncing the Death of Berlin? Wir sind hier nicht zum Spaß!
Torsten Oetken – "Extension 02, Schönhauser Allee, 1997"
Article by Alison Hugill in Berlin; Tuesday, Jul. 16, 2013
The title of the exhibition, Wir sind hier nicht zum Spaß!, reads as a provocation. It seems to say; unlike the present influx of international hipster dilettantes, we 'original Berliners' were serious about life, politics, and artistic collaboration. When passive-aggressive anger is regularly surfacing over the 'tourist problem' in Berlin, the exhibition at Kunstraum Kreuzberg/Bethanien offers one version of who these 'authentic Berliners' are and where their resentment lies.
Wir sind hier nicht zum Spaß! presents nostalgic artifacts from the youth culture of Berlin in the 1990s (concert tickets, festival bracelets, flyers, badges, posters, walkmans, tapes etc) alongside video and still images of the city's art and music scene at the time. One room recreates the atmosphere of an underground bar, Sensor, which hosted many of the decade's most emblematic moments. While some of the items on display are relatable, even for viewers who did not experience the 90s in Berlin, the overriding feeling of the exhibition is one of self-referential exclusivity.
Torsten Oetken – "Sensor / Holodeck, Hufelandstraße, 1995"
It seems strange to historicize–especially in the classic setting of a Museum–such a recent period in Berlin's cultural life. What kind of a statement does this gesture of historicization make? On the one hand, it is an interesting testament to the vibrant beginnings of Berlin's post-Cold War artistic scene. Yet, rather than imagine that period as ongoing, the curators seem to have proclaimed their exhibition as a post-mortem, isolating it, not just formally but on principle, from Berlin's present.
It should be noted, though, that many of the young artists who moved to Berlin in the early 2000s–however objectionable their presence may now seem to this earlier generation–were inspired by the legacy of the very counter-culture here memorialized (and many other alternative cultures that have blossomed in Berlin over the last century). The tendency to want to separate this particular moment from the overall affect of the city seems symptomatic of a dangerous vanguard elitism.
Martin Eberle "galerie berlintokyo letzter Abend" (1996)
While one can certainly appreciate that Berlin has changed a lot since the heydays of the 1990s, and in some crucial ways for the worse, the impulse of this 90s generation (Berliners and migrants from West Germany alike) to demonize the internationalization of Berlin has at times led to hostile and xenophobic outcomes. This attitude seems counter-productive to dealing with the very real problems of gentrification and artistic commercialization in the city.
The show at Kunstraum Kreuzberg/Bethanien raises many questions pertinent to the social dialogue that should be taking place between the 90s generation of Berlin's artists and musicians and the currently active one (assuming there can even be a distinction made between the two). The present youth culture of Berlin owes a lot to this historical moment, when new urban political possibilities emerged after decades of isolation and suppression. The series of talks presented alongside Wir sind hier nicht zum Spaß! will hopefully offer an opportunity to debate these issues and to problematize the unfortunate air of exclusivity emanating from the show itself.
KUNSTRAUM KREUZBERG/BETHANIEN
"Wir sind hier nicht zum Spaß!"- GROUP SHOW
Exhibition: Jun. 29 – Aug. 24, 2013
Mariannenplatz 2 (click here for map)
Accompanying Program:
Talk: "Kolonialisierung des Nachtlebens" with Daniel Pflumm, Jan Kage and Tobias Rapp
Moderation: Claudia Wahjudi
Tuesday, Jul. 23, 2013; 7pm
Talk and book presentation: "galerie berlintokyo" – Martin Eberle
Film screening and talk: "I'm glad I can't remember" with Tine Neumann
Tuesday, Aug. 06, 2013; 7pm
Book presentation and talk: "Die ersten Tage von Berlin – Der Sound der Wende" with Ulrich Gutmair
Thursday, Aug. 08; 7pm
Talk: "Wem gehört die Stadt?" with Jesko Fezer, Lutz Henke and Dolly Leupold
Moderation: Ute Adamszewski
Alison Hugill has a Masters degree in Art Theory from Goldsmiths College, University of London. Alison is the Arts & Culture Editor of Review 31 and is based in Berlin.
eight − four =


People come from far and wide to experience the Amsterdam buzz. In fact the city's magical energy keeps backpackers returning again and again. The Dutch capital will reward you with unforgettable memories, from exploring the notorious Red Light District, discovering some of the world's finest art, checking out the city's coffee shops; not to mention the killer nightlife scene. There's truly something for everyone.
Looking for a fun tour in Amsterdam? Here at St Christopher's Inns, we've handpicked some awesome tours that we think our guests will enjoy. Tours are a great way to experience a new place and meet new people from all walks of life, check out the tours below….
Arty Jordaan is one area to definitely explore in Amsterdam famed for its narrow canals, beautiful houses and cosy pubs - and then of course there's the the Nine Streets, the place to head for great shopping.
Amsterdam's two bustling squares Dam Square (housing the Royal Palace) and Leidseplein (the place to head on a night out) are prime areas to check out.
Boasting some of the world's best cultural experiences such as the Anne Frank House, boozy fun at the Heineken Experience, as well as its world-famous party atmosphere, you're guaranteed the time of your life.
Amsterdam's climate is influenced by the North Sea and Atlantic Ocean, which basically means the city benefits from cool spring/summers and moderate winters. Summer (June-August) can be lovely and warm with highs of 23 degrees.
November is the wettest month so make sure you pack an umbrella and a raincoat. January is the city's coldest month so if you're planning to spend New Year's Eve in the electric city, pack your warm jumpers.
Street food Raw herring is a Dutch speciality. It may sounds a little daunting, but there's a reason the locals love it. You'll find herring stalls dotted all over Amsterdam. Served with onions and pickles or in a small sandwich, this delightful snack is a must if you want to get an authentic taste of Dutch street food. The herring is sweetest between May and July!
Get an iAmsterdam card If you're a museum lover, then we recommend purchasing an iAmsterdam card for free entry or discounts to top museums and attractions, including The Rijksmuseum, Van Gogh Museum, the Stedelijk Museum and more. This citypass also allows unlimited free public transport throughout the city and a free canal cruise.
Smoking Amsterdam is one of the only cities in the world where you can smoke and purchase marijuana in coffee shops. In order to enter a coffee shop you must be 18 years old or over and carry ID. You can also make use of the indoor smoking room in the hostel.
Trams To get from A-B trams are the most popular and frequent service in the city (other than walking and cycling). You can buy a GVB day pass with prices starting from €7.50, valid on the trams, buses and metro.
Drinking age The drinking age in Amsterdam is 18 years old. We strongly advise to carry your ID at all times as nightclubs have a minimum age of 18. To buy alcohol in shops you also have to be 18. However, at 16, you're able to purchase spirits and wines that have less than 15% alcohol.
WHAT CAN YOU GET FOR YOUR MONEY IN AMSTERDAM?
Did you know biking is the best way to explore the city like a local?


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Sjursmäss (även stavad Sjulsmäss) firades den 23 december. Det var en kristen högtid i Jämtland, Härjedalen, Tröndelag och Nordland till minne av det lokala helgonet Sigurd, tidigare ärkebiskop i Nidaros stift.

I den norska almanackan har båda namnformerna Sjur och Sigurd namnsdag den 23 december.

På grund av sin regionala anknytning har sjursmässodagen även utnämnts till flaggdag för den inofficiella Jämtlandsflaggan. Eftersom den 23 december också är svensk flaggdag bör man därför, om man vill flagga jamtskt denna dag, ha två flaggstänger.

Övrigt
Namnformerna Sjur/Sjul för Sigurd används även som noanamn för Djävulen, som till exempel "gammalsjul".

Se även
Lilla julafton

Källor
Bo Oscarsson: "Jul och Sjursmäss i Jämtland" i Östersunds-Posten 23 december 1981

Noter

Externa länkar
Bo Oscarsson: Sjursmäss 26 december 2002

Kristna högtider
Jämtland
Härjedalen
Jul i Norge
Jul i Sverige
Nordland fylke
Temadagar i december


Monograph, who run regular Japanese supperclubs in Shoreditch and beyond, is running a regular Friday night supperclub in an underground venue in Dalston, including udon noodles and Japanese desserts. Tickets cost just £29, and it's BYOB.
"This new series of underground dinners will be centred around Japanese Udon noodles, presented with two separate pairings.
It will be dark, it will be loud.
Come with the people you would love to depart for a trip to Tokyo with or come alone and look for interesting people to share the journey with.
Talk with anyone, after all, it's not a restaurant.


If you're like me, you're constantly imagining the futuristic possibilities of fully-realized IoT ecosystems. In the context of the home, I imagine my car, GPS, and Nest working together to anticipate my arrival and make the proper adjustments to climate control. Or refrigerators, Egg Minders, and Amazon Fresh speaking effortlessly to one another to order eggs before I even know I'll need them… What a future. Other times, I'm convinced IoT will bring a dystopian future (as described in sobering detail by Wired).
We are, fortunately, some ways from that level of interconnection. IoT development is in its relative infancy and there are some key challenges that IoT developers must overcome. There seems to be consensus that environmental complexity is a major challenge, and that's a tricky challenge to overcome because complexity is sort of the point in the world of IoT – as a developer of an IoT device, I may integrate with many downstream 3rd party APIs, while other developers may consume my exposed APIs.
Before the increased demands of IoT, we might have tested our device within an ecosystem of APIs and devices by creating physical test labs. Now, that is an outdated and expensive proposition, and a developer often can't control the data coming from 3rd party APIs or devices (this is critical for edge case testing). This is why service virtualization is a critical part of the solution. We can simulate downstream APIs and control the data our device is consuming, to validate unusual situations during integration testing.
An internet connection (well, obviously).
Your own Amazon Echo or Echo Dot would improve the experience but you can also use a simulator.
An Amazon Developer account (https://developer.amazon.com/) and Amazon web services account (https://aws.amazon.com/).
A Microsoft account (https://signup.live.com) to access Microsoft Azure.
A basic understanding of REST APIs and JSON.
3. Under "Select blueprint" choose Blank Function and then select the Alexa Skills Kit as the trigger for our Lambda function. If you don't see "Alexa Skills Kit" in the list, you're probably not in the "US East (N. Virginia)" region.
What's happening here? We must specify the way our Lambda function will be invoked and the Alexa Skills Kit will allow Alexa to kick it off (once it receives the correct Utterance, which we'll configure later).
4. Give the function a name like "virtualWeather" and choose "Node.js 4.3" as the runtime. For the purposes of this article, we'll be using the Skill I've already built here so go ahead and download it now. If you'd like to look at the underlying source code you can find it here.
5. In the Code entry type dropdown, choose "Upload a .ZIP file" and select virtual-weather.zip that you downloaded in step 4.
"host" should be equal to http://api.openweathermap.org for now. "api_key" is the 32-digit alphanumeric key you will receive from OpenWeatherMap when you sign up as a Developer (see the prerequisites list above for where to do that).
8. Back on the "Configure function" page, you can leave the default choices for everything else and click "Next." On the Review page, choose "Create function" if everything looks good.
If your Echo is connected to this account and you've enabled this skill for testing on your account (you can do this on the Test page), you can speak to Alexa to test this out too. Say something like "Alexa, ask weather, what's the weather in 91016". And that's it for the Alexa setup! That wasn't so bad, right? But what about the central challenge of complexity and external dependencies raised at the beginning of this article? Our Lambda function relies on an external API which provides real-time, real-world data. As a Developer or Tester of an IoT device, how do we ensure that we are receiving the downstream data we need to test different conditions?
We have some simple logic here which adds weather appropriate phrases based on our weather description. For example, "Grab an umbrella!" to our Alexa's response whenever rain is mentioned in the description field of our JSON response. So how exactly are we going to test this? Unless you have a reliable rain dance ready or you happen to live in Seattle, this isn't going to be easy. Add test automation (for which we'd need consistent, repeatable data from the OpenWeather API which is unlikely) into the mix and we have a very tricky problem. The easy answer, clearly, is service virtualization. This will allow us to simulate the Weather API and test different circumstances. Parasoft has a free service virtualization platform (the Continuous Testing Platform) available for a free 30-day trial in Azure.
2. In the Marketplace, search for "Parasoft" and select "Service Virtualization On-Demand". You may select the "BYOL" option if you've previously received a special license from Parasoft. Click Create.
3. Provide a name for the VM then enter a username and password. You can choose to create a new resource group for the VM or add it to an existing VM. All other options can be left at the defaults. Click OK.
4. Select a virtual machine size (recommended is DS2_V2 or better). Click OK.
5. Under "Settings," you may change other configurations if desired. It is recommended that you do not change the default configuration unless you have a specific reason for doing so. Click OK.
6. Click the OK on the Summary view.
7. Click Purchase on the Buy view. After your free trial is complete (the first 30 days), you will be charged. The VM creation process will take several minutes to complete.
8. Once the VM's status is "Running," select the VM and copy its Public IP Address.
We've now imported the AlexaWeatherSkill system, virtual services and associated data.
13. In our environment (http:///em/ui/environments/1), we can now control the data being returned to our Lambda function to test different condition. This will change our Alexa's behavior on-demand!
I'd also highly recommend Brian Donohue's article here about creating your first Alexa skill. I also recommend Ryan Ray's article here. I've adapted code from both of their tutorials for the Lambda function we used in this article.


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Home » Fraud and Breach Prevention
Gregory A. Garrett, CISSP, CPCM, PMP, Head of U.S. & International Cybersecurity
Cris Ewell, CISO, UW Medicine
Dan Bowden, Digital Transformation and the Chief Information Security Officer at Sentara Healthcare
Bret Arsenault, CVP & CISO, Microsoft
Bob Fecteau, CIO, SAIC
Maurice Dawson, Director of the Center for Cyber Security and Forensics Education & Asst Prof of Info Tech and Mgmt, Illinois Institute of Technology
Don Kohtz, Director- Special Investigations Unit, Markel Corporation
Jason Castillo, Head of Enterprise Fraud Management at Citizens Bank
Vade Secure Announces Availability of Auto-Remediate for High-end and Automated Email Safety
By Enterprise Security Magazine | Friday, July 26, 2019
Vade Secure, a San Francisco based enterprise has been developing a comprehensive range of security aspects against the highly complicated email scams including ransomware, malware, spear-phishing/phishing. The latest from them is the accessibility to Auto-Remediate for Vade Secure for the Office 365.
Fremont, CA: Vade Secure is a trusted provider of email security, managing about 500 million email boxes across the world. Recently, Vade Secure announced the availability of the Auto-Remediate for the Vade Secure for office 365 . Auto-Remediate can be availed by all existing Office 365 users of the company without having to incur any extra cost.
Mostly, it is tough for any enterprise to manually investigate and identify new email attacks amidst the vast inflow of mails from various sources. Automation is the current favorite for sorting huge amounts of emails. Recognizing these trends with respect to automation, the recent addition of Auto-Remediate can be said to have taken place at the right time.
With the new feature, Vade Secure aims to extend its AI-powered mitigation and threat detection capabilities by empowering small enterprises and MSPs with an all-encompassing, automated and continuous safety during and after the attack.
Companies are now looking for solutions that are capable of extending total continuity and efficiency in identifying and detecting email threats and eliminating them without having to employ a human approach. Auto-Remediate is the perfect solution in such cases, which allows users to focus on other tasks without spending valuable time on detecting and preventing impending email threats.
Auto-Remediate can mechanically eliminate any malicious messages in the user's email inbox. This further enables to mitigate attacks even before they end up damaging the business. To make sure this happens, Auto-Remediate relies on Vade Secure's real-time insights into over 600 million email boxes around the world.
How Upgraded OT Security Platform Can...
What are the Biggest Fraud Trends in 2020?
Why Cybersecurity is Important in the...
Bitdefender Gravityzone's Advanced Endpoint...
Security Automation 2019
Security Analytics 2019
www.enterprisesecuritymag.com/news/vade-secure-announces-availability-of-autoremediate-for-highend-and-automated-email-safety-nid-1318-cid-77.html


Here you can find examples of where One Community have appeared in the press.
NOW EXTENDED TO FRIDAY 21st SEPTEMBER 2018.
Do you think your group deserves a Queens Award, like ours here in One Community?
The closing date 14th September 2018. Now extended to the Friday 21st of September as there have been technical difficulties with their website.
The Queen's Award for Voluntary Service is the highest award given to local volunteer groups across the UK to recognise outstanding work done in their communities.
Our Chief Executive, Jean Roberts-Jones and Trustee, Profession Sri Kandiah met the Queen herself to celebrate our award. We formally receive our award on Monday 17th of September 2018.
Next year, it could be YOU!
We are involved in many parts of community service and development so are taking a particular interest in the Eastleigh Bid.
If you have any comments or contributions to make, please follow the instructions on the information below.
Eastleigh Borough Council and the Mayor celebrate One Community at 40 years!
Eastleigh Borough Council, Mayor's Tea Party celebrating 40 years of One Community.
On the 27th of July 2018 a group of staff, volunteers and associates of One Community went to the Point in Eastleigh to celebrate our 40th anniversary. It was a hot and sunny day and we all enjoyed cakes, sandwiches, tea and coffees together and listened to some good speeches about how Eastleigh Borough Council and One Community do work in partnership. In front of our representatives the mayor and the council explained it has become more of a mutual respect and friendly relationship, to the benefit of the people of Eastleigh and surrounding areas.
It was a lovely way to spend an afternoon and we were particularly glad to have been nominated to receive a cheque from the council from their own staff charitable giving.
If you would like to see more, please check out our facebook page.
Mela Festival 2018 was planned over many months and luckily it was a sunny Sunday afternoon in July with no rain in sight!"Mela" is the Sanskrit word meaning 'meeting', 'fair' or 'gathering' and 'celebrations' of all kinds.
A riot of colour and frenzy of music and around 17,000 people from all backgrounds descended on Eastleigh town for the latest MELA festival.
Eastleigh's Leigh Road recreation ground was treated to a variety of dancing, music, food and fun from the various communities in the area. The group Bangra style dancing was a big draw, climbing and cycling, Mhendi and fabulous foods filled the park. It was busy and fun, lots of families and people of differing backgrounds attending. One Community ran a tombola and talked to many about signing up for volunteering.
One of the most popular shows was the dazzling Lion Dance and Chinese band.
Alongside all the dancing, music, shows and displays were a number of stalls from the Eastleigh Community. The Police and Fire service supported the event and it was fabulous to see lots of the public talking to a range of stall holders from Dementia services, encouraging physical fitness in children, to the library, through to care options for the elderly and almost everything in between.
If you would like to see more pictures, short clips and interesting snippets about the Mela or any other events One Community are involved in, check out our Facebook, Twitter and Instagram pages.
Did you go to the Mela?
What were your favourite parts?
We can't wait to see what MELA festival brings to Eastleigh next year!


Today I am sharing with you my review of the new limited edition Huda Beauty Lip Contour and Strobe kits. Please excuse my hair in todays video, I tested out a new product I my hair feels like I ran a glue stick through it! At any rate I still wanted to get this review out for you today as these kits are limited edition. Hope you enjoy.
The Muse set is gorgeous! I love the darker set on you, it looks beautiful.
I picked up Muse & Angelic and Trophy Wife & Shameless. I also have the lip strobe in Mystic. I liked the sets. I also wear the lip strobes on their own but I like a shiny or slightly glitter lip. I like her matte formula as it is not as drying as some but do prefer the strobe over it. I also find since they aren't as drying they don't last as long as a Kat Von D liquid lip. Her lip pencils are really nice so glad I got the set and got to try them. Thanks for the review so I could see some of the other colors.
My HONEST First Impressions Review On KKW Beauty Powder Contour & Highlight Kits + Swatches!


[0809.3762v3] Climate Science: Is it currently designed to answer questions?
Title:Climate Science: Is it currently designed to answer questions?
Abstract: For a variety of inter-related cultural, organizational, and political reasons, progress in climate science and the actual solution of scientific problems in this field have moved at a much slower rate than would normally be possible. Not all these factors are unique to climate science, but the heavy influence of politics has served to amplify the role of the other factors. Such factors as the change in the scientific paradigm from a dialectic opposition between theory and observation to an emphasis on simulation and observational programs, the inordinate growth of administration in universities and the consequent increase in importance of grant overhead, and the hierarchical nature of formal scientific organizations are cosidered. This paper will deal with the origin of the cultural changes and with specific examples of the operation and interaction of these factors. In particular, we will show how political bodies act to control scientific institutions, how scientists adjust both data and even theory to accommodate politically correct positions, and how opposition to these positions is disposed of.


Crawford city is located in Nebraska State, Dawes County and has a unique zip code assigned by the US Postal Service Office.
Crawford Area Code is 308 and Time Zone is Mountain (GMT -07:00).
The US ZIP Code basic format consists of five decimal numerical digits assigned to the Crawford City. An extended ZIP+4 code, introduced in the 1980s, includes the five digits of the Crawford ZIP code, a hyphen, and four more digits that determine a more specific location within a given ZIP code in Crawford, Nebraska.
The Crawford Zip Code is 69339.
If you want to send a mail to Crawford City, you should use the 69339 Zip Code.
In 1983, the U.S. Postal Service introduced an expanded Crawford ZIP code system that it called ZIP+4, often called "plus-four codes", "add-on codes", or "add ons". A ZIP+4 code uses the basic 69339 Zip code plus four additional digits to identify a geographic segment within the five-digit delivery area, such as a Crawford city block, a group of apartments, an individual high-volume receiver of mail or any other unit that could use an extra identifier to aid in efficient mail sorting and delivery in Nebraska.
The Crawford Zip Code in Nebraska is 69339.
What is the zip code for Crawford NE?


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Home > Resources > Holidays at Home > Rosh Hashanah
Rosh Hashanah 2019 will begin September 29 at sundown and last until September 30 at sundown.
Rosh Hashanah, the Jewish New Year, and Yom Kippur, the Day of Atonement, comprise the "High Holy Days" of the Jewish calendar.
Rosh Hashanah, which literally translates to "head of the year", is a time for celebration and sweetness. We mark this joyous occasion with apples and honey (offering sweetness), round challah (to symbolize the cycle of life), friends and family, and worship services with the blowing of the shofar, all in preparation for a sweet new year!
We invite the entire community to observe Rosh Hashanah at Rockdale Temple. Services are available for children, families, and adults. Click here to learn more about the High Holy Days at Rockdale!
If you are unable to attend High Holy Day services at Rockdale, you now have the option to tune in at home on your computer! Click here for access to live-streaming services!
Scroll down for great Rosh Hashanah information, how-tos, activities, mitzvah opportunities, music videos, recipes, and more!
PRACTICE SINGING THE BLESSINGS!
Learn to Read and Sing the Blessings for Rosh Hashanah!
Rosh Hashanah Kiddush & Shehecheyanu
Rosh Hashanah Blessings for Special Foods
MORE ABOUT ROSH HASHANAH
What is the Meaning of the High Holy Days?
Rosh Hashanah Basics
Rosh Hashanah Glossary
What is Rosh Hashanah?
LEARNING FOR ADULTS
Rabbi Coran and Adam Bellows Teach about the Shofar
9 Things You Didn't Know about Rosh Hashanah
Explore Rosh Hashanah at ReformJudaism.org
New Year, Take Two: A Second Chance for a Conscious Year Ahead
Rosh Hashanah 101
Webinar: Sounds and Tastes of the New Year
Torah and Haftarah Readings for the High Holy Days
Rosh Hashanah and Yom Kippur Readings - with Social Justice Themes
ACTIVITIES & VIDEOS FOR CHILDREN
Rabbi Coran Reads for Rosh Hashanah!
Tips to Engage Your Family in the New Jewish Year
Shalom Sesame: Rosh Hashanah Hannah
Shalom Sesame: The Sticky Shofar
Rosh Hashanah Activity Pages
Rosh Hashanah Coloring Pages
Rosh Hashanah Crafts
Make an Apple Into a Honey Bowl!
Kids Try Jewish High Holiday Traditions
Paper Apple Centerpieces
ROSH HASHANAH MITZVAH OPPORTUNITIES
Social Justice and the High Holy Days
A High Holy Days Social Justice Guide
Give to MAZON: A Jewish Response to Hunger
CELEBRATE WITH MUSIC!
Why is the Music Different during the High Holidays?
Avinu Malkeinu (Janowski) sung by Barbra Streisand
Shofar Blast by Ellen Allard (kids)
Fountainhead sings "Dip your Apple"
Six13 sings "High Holiday Mashup"
Six13 sings "Shanah Tovah"
How to Make Round Challah
Honey Cake for Rosh Hashanah
Apple Nachos
Apple, Meet Your Sweetest Match
Pumpkin Bread with Cinnamon Whipped Honey
Smoked Salmon Baked Omelette
18 Delicious Recipes for Rosh Hashanah
Rosh Hashanah Traditional Foods and Recipes


This entry was posted in Holy Spirit, love, Patience, peace and tagged Christ Jesus, Christianity, creation, creativity, Epistle to the Philippians, God, God the Father, imagination, Jesus, London, Religion and Spirituality by CommutewithChrist. Bookmark the permalink.
God bless you and thank you for leading us all in prayer today!
Thanks for sharing, really enjoying your blog!


I'm calling these Strawberry Peach Crumbles, but you can make them with just about any fruit (fresh or frozen). I've been eating these all summer long, mostly with fresh strawberries. Now that we're transitioning into fall (!!!), you better believe I'll be trying these out with freshly picked apples as well (I'll report back on how that goes).
Granola is one of my favorite things to make, mostly because it's so easy to master. It's one of the few foods that's socially acceptable to have both for breakfast (with yogurt and fruit) and dessert (over ice cream). Here I'm sharing my go-to granola recipe.


Our little Ava is a very sick girl right now in critical care. Yesterday afternoon her temp started to come up and her heart started beating faster and it was still high at 10:00 last night so I came back to the hospital to stay with her. Around 4:00 am she still had the high heart rate and wasn't settling so the team from the critical care unit came up to assess her and eventual brought her down to their unit.
She spiked a fever of 41 degrees after we got here so she clearly is fighting some sort of infection or virus. And that combined with a very poor functioning heart is not a good combination.
Right now she is laying on a cooling mat to bring her temperature down and she is sedated and on pain killers. Her heart rate does seem to be dropping and she is comfortable, but now we have to wait and see what God's plans for Ava are.
Our beloved pastor Norm and his wife Cindy came to see us yesterday along with friends Dawn and Cory. Dawn gave me this verse for Ava which I love and is so perfect.
Once again, no matter what happens, God is our strength, forever!


text:
Crosby powering Penguins as desperate Panthers visit
It seems as if Sidney Crosby is nearly willing the Pittsburgh Penguins into the playoffs.
Entering Tuesday's game against the visiting Florida Panthers, Crosby has 10 points over the past four contests, including a goal and four assists Saturday in a 5-1 win at Montreal.
The Pittsburgh center and team captain, named Monday as the league's No. 3 star of the week, had climbed into the top five in NHL scoring with 83 points going into Monday's games.
"Just to see it and sit there and watch it front row, you really know he's taking this team over and doing it every night," linemate Jake Guentzel said.
With his next point, Crosby will become the 48th player in NHL history to reach 1,200 in his career. Crosby also is being pushed by the Penguins for Selke Trophy consideration for his strong backchecking and two-way play.
"He understands the position we're in. He's doing everything he can to help this team win," Pittsburgh coach Mike Sullivan said. "He just plays the game the right way. ... He's the best 200-foot player in the game."
Pittsburgh has made the playoffs the past 12 seasons, or every season of Crosby's career except his rookie campaign. With 17 games remaining, the Penguins (34-22-9, 77 points) are clinging to a wild-card spot in the Eastern Conference.
"(Games are) going to be important all the way through here," Crosby said. "Everyone's trying to do their part. Especially with the injuries we have, everyone's just trying to make sure that they're contributing in any way they can."
The Penguins are without three of their top four defensemen -- Kris Letang, Brian Dumoulin and Olli Maatta -- as well as winger Bryan Rust. Dumoulin returned to practice in a limited capacity Monday, while Letang and Maatta skated before practice.
Florida (28-26-11) sits 10 points behind Pittsburgh, and its playoff hopes are quickly dwindling.
That was underscored Sunday when the Panthers fell 3-2 against Ottawa, which is last in the NHL and had lost seven straight. The defeat ended Florida's five-game point streak.
"There wasn't a lot of gas in the tank," Panthers coach Bob Boughner said.
It was the Panthers' fifth game in seven days, and things don't let up much. The game in Pittsburgh is the first of two straight on the road -- the other coming Thursday at Boston -- followed by a Friday date at home vs. Minnesota.
"The schedule just keeps getting tougher," Boughner said. "This time of year, travel, Boston, Pittsburgh, then come home for a couple and then back out West again. Lots of games in March. It's our busiest month of the year. We've just got to keep plugging and trying to keep pulling points."
Florida is trying to avoid missing the playoffs for the 20th time in 25 seasons.
"We've got to be able to accumulate points and find ways to win," Panthers winger and top goal scorer Mike Hoffman said.
It might be a little too late after the loss to the Senators.
"We needed two points and need two points every night now. This was not good," center Vincent Trocheck, a native of suburban Pittsburgh, said. "We're not in a playoff spot, and no one is going to be happy with that. This is our job, right? Our life. We're not happy to lose games. No one is."
The two teams split the first two meetings this season, as the Panthers fell at Pittsburgh 5-1 Jan. 8, before picking up a 3-2 overtime win Feb. 7 at home.


Does any current virtual robot library fit with the KR120 R3900 ultra K?
I just checked and we've only got the 3700 K at the moment. However we do integrate new robots for members, so getting it into PRC wouldn't be a problem. Also, the member version allows you to define your own robots.


HotSchedules, a leading provider of workforce and back office solutions for the restaurant and hospitality industries, announced record-breaking usage numbers by its over 3 million active users. In 2018 over 170,000 restaurant locations across 61 countries leveraged the HotSchedules platform for its workforce and back office solutions, enabling managers with the tools needed to take the next best action to maximize efficiency, minimize costs, increase revenue and create a better experience for guests and employees alike.
Last year, HotSchedules customers scheduled over 2 billion labor hours and traded over 14 million shifts. The integrated talent development solution of HotSchedules continued to demonstrate strong results in enabling employees to learn and grow anytime and from anywhere. Last year, 6.5 million training courses were delivered through the product.
With a proven track record of success, HotSchedules executed a strong pipeline of new and expanding partnerships with customers including Del Frisco's, Noodles & Co., Natural Grocers, Logan's Roadhouse and Jason's Deli, among others.
As a result of record adoption and usage, the HotSchedules iOS App ranked as the No. 1 most downloaded paid business app on Apple iTunes Store for 2018. HotSchedules' ongoing commitment to innovation was exemplified in 2018 with the launch of HotSchedules Essentials – two new service levels offering small businesses in industries including healthcare, entertainment, recreation, and personal services access to the best of HotSchedules' industry-leading employee scheduling, communications and time and attendance functionality.


Demonstration circuit 1816B is an off-line isolated flyback LED driver featuring LT3799-1. The demo board provides a single constant current output of 3A over an LED string voltage from 22V to 38V. It is optimized to operate over a wide AC input voltage range (90VAC to 305VAC, 47Hz to 63Hz). LED current typically stays within ±5% over the whole input voltage range. It provides a high power factor (>0.9) enabling a single design to be used worldwide. It is also designed to comply with the IEC 61000-3-2 Class C harmonics standard and the EN55015B conducted EMI standard.
DC1947A: Demo Board for the LT3799-1 Offline Isolated Flyback LED Controller with Active PFC.


text:
require "rabbitmq/http/client"

class GusSubscriber < ActionSubscriber::Base
  def spoke
    $messages << payload
  end
end

describe "Automatically reconnect on connection failure", :integration => true, :slow => true do
  let(:connection) { subscriber.connection }
  let(:http_client) { RabbitMQ::HTTP::Client.new("http://127.0.0.1:15672") }
  let(:subscriber) { GusSubscriber }

  it "reconnects when a connection drops" do
    ::ActionSubscriber::auto_subscribe!
    channel = connection.create_channel
    exchange = channel.topic("events")
    exchange.publish("First", :routing_key => "gus.spoke")
    verify_expectation_within(5.0) do
      expect($messages).to eq(Set.new(["First"]))
    end

    close_all_connections!
    sleep 5.0
    verify_expectation_within(5.0) do
      expect(connection).to be_open
    end

    channel = connection.create_channel
    exchange = channel.topic("events")
    exchange.publish("Second", :routing_key => "gus.spoke")
    verify_expectation_within(5.0) do
      expect($messages).to eq(Set.new(["First", "Second"]))
    end
  end

  def close_all_connections!
    http_client.list_connections.each do |conn_info|
      http_client.close_connection(conn_info.name)
    end
  end
end

redpajama_set_name: RedPajamaGithub