text:
Q: my app don't working in android 6.0 platform I did an SMS application. My app working from platform 10 to platform 22. But doesn't work on platform 23 (so android 6 platform). I'm using Android studio. Why my app don't work on android 23 platform?
(Note: On Android 23 platform my app enjoying "stopped error")

A: Is your app targeting V23?
If you are targeting V23 take in account that SMS permissions are considered danger ones and you have to ask for permission at runtime.
If it isn't your issue please provide a detailed stacktrace of your crash.

A: In android 6.0 SMS, WRITE_EXTERNAL_STORAGE permission get from user run time
check follow url for your reference
int permissionCheck = ContextCompat.checkSelfPermission(this,
                Manifest.permission.READ_EXTERNAL_STORAGE);

        int permissionCheck1 = ContextCompat.checkSelfPermission(this,
                Manifest.permission.WRITE_EXTERNAL_STORAGE);

        ActivityCompat.requestPermissions(this,
                new String[]{Manifest.permission.READ_EXTERNAL_STORAGE},
                1000);

        ActivityCompat.requestPermissions(this,
                new String[]{Manifest.permission.WRITE_EXTERNAL_STORAGE},
                2000);

        Toast.makeText(this, permissionCheck1 + " Permission " + permissionCheck, Toast.LENGTH_LONG).show();

A: I think you have update your SDK first to API level 23, and the rebuilt your project and Run the App...
Hope this will works for you...


text:
Home » queen elizabeth
Browsing: queen elizabeth
The coronation of King Charles will be in May, know what is its religious significance and why it is important
World October 12, 2022
LondonThe coronation of King Charles III will take place at Westminster Abbey on 6 May 2023. But what is a…
Nine year old nephew Prince George became a big threat to Uncle Harry, know what is the matter
World September 25, 2022
LONDON: King Charles' younger son Prince Harry and his wife Meghan Markle are already embroiled in controversy. Now a new…
Now this is the biggest challenge in front of King Charles, what will the new King of Britain face after his mother's departure?
London:After the funeral of Queen Elizabeth II of Britain is over, Maharaja Charles III will have to face many issues…
Queen Elizabeth's funeral complete, coffin buried next to husband Prince Philip, see photos
On Monday, Queen Elizabeth II's coffin was lowered in the royal vault of St George's Chapel at Windsor Castle as…
Britain changed but tradition not, why is the royal coffin still kept for the last glimpse?
London: When Maharaja George V, the grandfather of Queen Elizabeth II, died 86 years ago, many homes in Britain had…
8 km long line of those who paid tribute to the Queen, the number of people coming after waiting for 14-14 hours
London: Following the death of Britain's Queen Elizabeth II, the British government on Friday stopped more people from joining the…
The Royal Guard standing near Queen Elizabeth's coffin fell unconscious, was immediately stopped Live, watch video
London: Queen Elizabeth's coffin is placed in West Minster Hall for the last time to be seen. But during this…
Tribute to Darling Mama, I will serve the nation for the rest of my life… Britain's new King Charles promised
World September 9, 2022
London: In his first address to the nation as King of Britain, King Charles III said on Friday that he…
Where will the 4 pet dogs of British Queen Elizabeth II remain, confusion persists after the death
London: After the death of Britain's longest-reigning monarch, Queen Elizabeth II, there has been confusion about the arrangement of her…
Queen Elizabeth and cricket: The story of Queen Elizabeth from the field, if she could not give autograph to the cricketer, she sent her own photo
Sports September 9, 2022
New Delhi: Former Australian cricketer Dennis Lillee once asked for an autograph from Queen Elizabeth, but due to royal protocol,…

redpajama_set_name: RedPajamaCommonCrawl


My goal is to help each school put forth the best possible online reputation in order to appeal to their greater community and strengthen their existing community.
I meet with individual schools to help put together a social media plan that fits the capacity of each school site. I oversee all social media accounts I create and gain access to. I also offer photographic support, and consult in the creation, editing and redesigning of new current websites and help faculty create an online presence.
In addition to individual meetings, I also have a Prezi presentation that breaks down social media and its use for school promotion for administrators, faculty and staff with tips on educating students about social media. I also give professional development to teachers for School Loop.
Please don't hesitate to contact me at justin.frank@lausd.net or (310) 650-3572 to book a meeting, professional development or any questions.
Have a School Loop Website?
School Loop has a contract with LAUSD and is a website provider that offers websites that are no cost to the school site. If you already have a School Loop site and need with support with editing, please let me know. I can also assist you in getting a School Loop site if your school doesn't already have one.
I also offer a PD for teachers to train them on creating their own course pages on School Loop.
Want to Get Your School Started on Social Media?
Click here to access the LD West Social Media Guide to get you started!


text:
La rue des Écoles à Aubervilliers est l'une des artères principales du centre-ville.

Situation et accès
En partant de l'ouest, cette rue forme le point de départ de la rue Chouveroux, puis croise la rue André-Karman. Elle laisse ensuite sur sa droite, l'impasse Binot et l'impasse de l'Espérance.

Elle traverse ensuite la rue des Cités, la rue Henri-Barbusse, puis arrive au carrefour de la rue des Postes, où les deux rues confondues, se terminent à l'avenue de la République

Origine du nom

L'origine du nom de cette rue tient aux écoles qui y ont été bâties sous la Troisième République dans le cadre des lois Jules Ferry.

Historique
Cette rue fut percée dans la deuxième partie du , concomitamment à l'occasion de la construction du Groupe scolaire en 1876.

Bâtiments remarquables et lieux de mémoire
 Synagogue Ohel Yaacov
 Polyclinique d'Aubervilliers.
 L'école Jean-Macé a été inaugurée en 1876.
 Un puits artésien y a été creusé en 1860.

Notes et références

Ecoles

redpajama_set_name: RedPajamaWikipedia


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Wet hair and work into a lather. Rinse. Repeat if needed. Follow with Original Conditioner for Damaged & Color Treated Hair.


Kansas City Zoo This Zoo Has IT All. EVERYTHING at ONE SITE. A MUST SEE , TOP SITE.
Montery Bay Aquarium Dive right in, This may not be a normal zoo but check it out. A favorite here.
The Birmingham Zoo Some very interesting things are to be found here. A good site for background information.
Denver Zoo This site has improved quite a lot. See Lion's Den And sneak a look into the new birdhouse.
Electronic Zoo Online Zoo, Almost everything. thats on line. CHECK THIS ONE OUT.
National Zoo A Site Full of Great Things. Another older site, But this one has some good content.
San Diego Zoo The Famous southern California zoo.


Over at Addicted to Inchies Yahoo Group this month we are making inchie books instead of our usual make themed pick inchies.
My partner recently lost her husband who was battling cancer so I found this nice verse to add to my inchie book.
This first pic is the front and back cover and I attached a charm to the bottom ring that says Peace.
The first inside page is done with a plain piece of cardstock with ripped pieces of masking tape layered one over top of the other till the cardstock is covered. I then took my Twinkling H20's and painted using more than one colour blending one into the other then applied the words.
And this page is done using Twinkling H20's on cardstock with orange, purple and looks here like gold. I placed eyelets on all the pages then made my own rings out of wire to hold the book together.
I hope JoJo likes it. It was fun and it all came together as I had planned.
Don't forget inchies are a one inch x one inch square so if you can imagine a book this small, here it is.
I have completed I think 10 or more now, they are very addicting.
And these are some Zetti cards I made for a FlickR group I belong to, Let's Swap ATC's.
I always thought Zetti was on a dark side of art of which I don't really find appealing to me but it is not, it can be if you chose it to be but basically you can stick heads on bodies that are larger or smaller, different legs and arms. I have played around with backgrounds using old book pages, acrylic paints. I used lids to make circles and markers to do borders. It is a free style sort of Zany art as I like to call it.
Zany Zetti is still available for my trade group but the 2 below it are spoken for and soon to be travelling to their destinations.
So have fun with art, relax and just go for it.
Oh Lesley the inches book is just lovely. A very appropriate gift for a grieving friend to hold in her hand at a time like this. I love the verse. What a kind friend you are.
Lae love your new summery look blog!
I adore the inchies book - so touching and thoughtful.
And I love anything zetti - fab cards!!
Love the look of your blog! Great artwork! You are so creative!
Oh Les, your inchies book is just wonderful...love the background effect with the masking tape too and LOVE your zetti cards - absolutely fabulous!!
Love the inchy book. Such a thoughtful gift.
Love your atc's and inchie book Les!
Your new blog look is looking pretty and summery too!


Applications are invited for United Nations – Nippon Foundation of Japan Fellowship Program in the USA. International applicants are eligible to apply for these fellowships.
The program aims at providing the necessary knowledge and skills to assist developing states towards the formulation of comprehensive ocean law and policy and to implement UNCLOS and related instruments to achieve sustainable management of their ocean spaces, resources, and activities.
Phase One: 3-month Research and Training – normally undertaken at DOALOS at the United Nations Headquarters in New York.
Phase Two: 6-month Advanced Academic Research and Study – undertaken at one of the prestigious participating Host Institutions and under the guidance of subject matter expert(s) who have recognized in-depth expertise in the Fellows' chosen field of study.
International applicants are eligible to apply for these fellowships.


» Get paid to learn! You will receive an industry award wage (average work = 12hrs/week for approximately 35weeks/year. This differs for each internship and is negotiable with the employer).
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» Great opportunity for networking in your chosen field.
» Graduate with a head start!
NOTE: Applicants must be in the 2nd half of their course (undergraduate level in a relevant field) to apply AND want to contribute to the mission of the SDA church.
Students must have the unrestricted and ongoing legal right to work in Australia i.e. Australian or New Zealand citizenship and/or a work permit (student visas do not count).
To stay in touch with internship updates, please connect with us.
University student Internship - Don't miss this opportunity!
Sanitarium is a progressive and dynamic company that is Australian owned and produces Australia's favourite breakfast cereal - Weet-Bix and Australia's leading liquid breakfast – Up & Go. Our Head Office is located at Berkeley Vale on the Central Coast.
We have a rare and exciting opportunity for a highly motivated University student who is currently in their second year of an Undergraduate Accounting degree, to join our team in the role of Accounting Intern. The intern would commence employment with us in the 2019 academic year and would continue throughout the duration of their final year of studies.
The successful candidate will be a competent user in Microsoft Office Suite, particularly Excel and have good analytical skills. Within this role you will gain exposure to SAP accounting systems, cost allocations and financial processes.
You will work within the Business Advisory & Finance teams, helping with preparation & analysis of weekly and monthly reports, distribution cost allocations and invoice coding, reconciliations, and other financial related tasks where required.
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We are an organisation driven by our mission and values. If you share our passion for what we do, our products and can respect our Christian based principles this is a great opportunity.
To apply for this position please click here and forward your CV and transcript to hrservices@sanitarium.com.au.
The appointing body reserves the right to fill this vacancy at its discretion and close applications early.
Just started studying or preparing to graduate this year? Now is the time to register your details with Adventist Employment. You will receive regular updates of available positions within the South Pacific (including internships) as well as career and employment tips.


text:
How Employees Shaped Strategy at the New York Public Library
An inside look at the organization's radical approach.
Bruce A. Strong
Mary Lee Kennedy
The New York Public Library is one of the largest public libraries in the world, with 18 million visitors yearly, a budget of nearly $300m, and 93 branches. It serves vastly diverse populations: toddlers and caregivers, new immigrants, lifelong learners, famous novelists, and scholars. Although based in New York City, it serves a global audience of researchers and tourists.
Library leaders knew that given the immense changes brought on by digital innovations, as well as shifts in the communities that the Library served, it would need to evolve. How to transform such a huge, iconic institution, wrapped in history, into a nimble player? How to provide hyper-local services tailored to the diverse needs of its patrons while also upholding a consistent and high standard of service?
In the spring of 2014, we proposed a radical approach: offer anyone on staff – over 2,500 individuals, many of them union members – the chance to shape the library through strategic conversations with senior leaders. We believed that if the Library was to be truly nimble, senior leaders couldn't unilaterally come up with a plan. Involving staff in conceiving, designing, and implementing the change would result in a course of action that was more fit-to-purpose and more likely to be well executed. Staff would fully understand the changes and be accountable to each other for their implementation.
The conversation would be neither bottom-up nor top down. Staff would take a lead role in designing, testing, and advocating solutions. Leadership would shape the conversation to ensure proposals were strategically on-point. Senior leaders also would provide resources, guidance, and act as decision makers.
But would involving so many people work in practice? How to get them engaged? How to ensure that the conversations didn't bog down or become chaotic?
Several organizations for whom we had worked or had researched used a technique we call "innovation communities" to structure strategic conversations so that they're both efficient and effective. These diverse groups of volunteer employees work across organizational boundaries and outside of their regular operational duties. They are empowered by – and in frequent communication with – senior management. Innovation communities had been used by Best Buy to grow its portion of the women's consumer electronics market by $4.4b in less than five years. Boston Children's Hospital used them to make advances in telemedicine. Japanese pharmaceutical Eisai used them to improve care for Alzheimer's patients.
Convinced, the library's management team created three innovation communities with each one focusing on a core library function: circulation, collections, and reference.
Each community was structured as three embedded circles. The smallest was the "core team" consisting of five to seven staff members from each of the three boroughs served (the Bronx, Staten Island and Manhattan). Their expectation was to spend about a day a week for the next six months on the identification, design, and testing of a business model innovation.
The next larger circle was made up of "testers," approximately fifty staff members who piloted the solutions. Finally, all staff were invited to be "conversationalists" and participate by providing their ideas, critiques, expertise, and encouragement.
Internal experts helped innovation community members with unfamiliar tasks such as data collection and analysis, environmental scanning, and preparing and delivering management-level presentations.
The three innovation communities shared virtual, physical, and temporal spaces to promote cross-community exchanges. The virtual space was a social media platform open to all staff. This social network was designed to reduce the friction typically found in a hierarchical organization: we wanted staff from any branch to be able to communicate with each other and with senior managers, unmediated by reporting structures.
The physical space was a room in the Library's Midtown Manhattan branch dedicated to the innovation communities where the core teams, and other interested parties, could work together. Painted on many of the walls were huge whiteboards, where the three teams worked on designs and exchanged ideas.
The temporal space was a day set aside each week: the three communities met on Wednesdays in order to reduce scheduling issues and allow support people – for instance the data and analytics experts — to meet with the three communities within a predictable block of time.
The three core teams were given a month to present to senior leaders options for their experiments, and the capabilities needed to try them. They were asked to describe their solutions, the benefits to the intended audiences, and to list up to five hypotheses that could be tested before the end of their six-month project. Built into the template were the library's guiding principles: that its services had to be consistent, convenient, empowering, and inspiring. Each team came up with two to three of these "options statements."
We knew from the start that coming up with all this in a month would be a challenge. But we anticipated that the very rawness of the presentations would create opportunities. Because the recommendations wouldn't be fully baked, it would be easier for senior managers, and the rest of the community, to challenge assumptions and conclusions without seeming threatening. We wanted to create an environment where "thinking out loud" was encouraged.
The discussion around the options statements played out as we had hoped. In the crucible of these conversations, the library's strategy was transformed from an impersonal statement into a living, internalized guide. Having to develop testable hypotheses forced the participants to think deeply about how to structure their work so that it was rigorous and data-driven.
In partnership with senior management, and with the support of the internal experts and the rest of the community, the options statements were strengthened and then approved. The core teams then moved to design and test their solutions with senior management, the testers, and the conversationalists. Nearly 250 staff members (almost 10% of Library staff) became involved in the process, providing their own input as they became familiar with the core teams' work.
The Circulation team examined how books flow through the NYPL system. Of the total circulation of about 23 million, about two million items are reservations (called "holds" in library lingo) — typically items that the library needs to transfer from another location. The team discovered that the library was processing holds more slowly than its North American peers because of inefficiencies throughout the process. Implementing the team's recommendations should result in at least a 20% reduction in wait times for books while providing patrons with better information about where they are in the queue. The changes will also reduce staff workloads.
The Collections team focused on improving the library's ability to provide content to youth and young adults. They made a major discovery: this population was two and a half times more likely to use books and other materials in the library than check them out. NYPL librarians had long suspected that in-house use was substantial, but the magnitude was surprising and something for which the library's business model had never accounted. Of course, more usage is good news. But given this evidence, the team concluded that the library could do much better at serving this population. More materials could be made available for in-house use (as opposed to expecting patrons to put them on hold from other branches). And the collections could be tailored to serve local needs though more interaction with local educators and schools. The team also believed that this solution would appeal to branch librarians' professional pride by providing them more autonomy to shape their collections. The solutions, which required a radical rethinking of how materials circulate, are scheduled to be rolled out to all branches by the end of 2017.
The Reference team came to another startling–and in this case concerning– revelation. While NYPL's online reference service was heavily used, and its research libraries conducted in-depth consultations on a regular basis, patrons almost never consulted with librarians at neighborhood branches. The team discovered that when general reference support was sought, staff often didn't have the time or skills to meet patrons' needs. Based on its analysis of the issues, the team piloted a "reference receipt" for patrons with recommendations for book titles and online resources to support research beyond the initial reference conversation. The teams also tested signage at the local branches to guide patrons to such common services as signing up for using computers so that staff would have more time to offer reference services. And finally, they recommended modular training sessions for staff on providing those services. All three recommendations were adopted.
Both staff and senior leaders were enthusiastic about these outcomes – in fact, the library already has launched the next set of experiments.
Staff was energized by the opportunity to shape how the library worked. As a core team member put it, "We entered the process with the perspective of employees and came out with the perspective of leaders." They were deeply appreciative of the chance to interact with, and learn from, peers across NYPL, something that rarely happened otherwise. They were excited to master new skills and knowledge relevant to librarians such as sophisticated data collection and analysis.
The core team members turned out to be superb community organizers. They rallied their peers to take on significant testing tasks and to participate in the overall conversations. They also were the best advocates for their solutions. And they had an innate notion of the types of conversations that would generate real change.
The project expanded their sense of belonging. Many had felt isolated in their individual branches. Now they had a clear line of sight to the entire system through their interactions with colleagues from across the institution. This institution-wide connection went beyond the work per se; staffers also felt much more connected to the library than ever before. As one participant put it: "Doing Innovation Communities changed everything for me. I went from looking for jobs outside of NYPL to looking at this system and thinking, 'Where do I want to be next?' It helped me think about the NYPL system and where my career could go here."
It wasn't just staff who were transformed. Senior leaders better understood how the library operated "on the ground" and they began to see how employee involvement in strategic conversations opened up real possibilities for reducing managerial burden. Staff — when offered meaningful autonomy and real opportunities for mastering their professions — become problem-solving leaders in their own right. And the cost was marginal. The project released staff energy that was more than ready to be tapped.
This isn't to say that everything went completely smoothly. We were initially overly enthusiastic about exposing staff to new management concepts and templates, unnecessarily overwhelming them. The Reference team's pilots didn't immediately produce the desired results. Not everyone in the hierarchy –top, mid or bottom – was comfortable with networked, open conversations that exposed problem areas for all to see. And two of the three teams went beyond their six-month mandate, over-burdening participating staff and the branches in which they worked.
Despite these difficulties, innovation community participants more than rose to the occasion. Staff cared deeply about the work and put in much more effort than anticipated.
What surprised us most was the importance of the social aspect of the innovation communities. Community members consciously forged new and strong bonds of comradery, commitment, and common purpose.
And that brings us to our concluding point: strategy as currently practiced rarely emphasizes the importance of community. Our experience with the Library highlights it. The social bonds created by the innovation communities, we believe, will be integral to the Library's continued efforts to realize its strategic direction. It will be up to leadership to continue to foster the social environment and the conversations in which strategic ideas are born, nurtured, and carried out.
Strategy Planning and Execution Course
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Read more on Strategy execution or related topic Experimentation
Bruce A. Strong is an author, consultant and a founder of the Network Leadership Group, which offers coaching and action-learning programs to help management fully engage the smarts and energy of staff and partners.
Mary Lee Kennedy partners with organizations to build strong communities that take full advantage of the information landscape. She was director of Knowledge Networks at Microsoft, Senior Associate Provost at Harvard, and most recently, Chief Library Officer at the New York Public Library.


On the tape, Grover guides the listener through a series of puzzles and games, but requests rather emphatically that the listener never push the red button on the Talk 'n Play unit. If the red button is pushed, Grover usually offers gentle corrections ("We are not pushing the red button today!") but occasionally he becomes a bit exasperated.
Please Don't Push the Red Button includes the song "Everyone Makes Mistakes".


text:
Q: Can I send sms using Sinch with Squarespace, which does not give access to server side code I need to send SMS using Sinch from a Squarespace app, which does not provide access to server side code. I am wondering if their JavaScript SDK can do it, but I can't seem to figure out any help of this. Has anyone does this before.

A: You can but you should not do that because you secret will be exposed so any one could use your account. The code that sends sms should be on server side (in any  language you want)

redpajama_set_name: RedPajamaStackExchange


text:
Luciano Fadiga (born 8 August 1961) is a neurophysiologist at the Human Physiology Section of the University of Ferrara and a Senior Researcher at the Istituto Italiano di Tecnologia of Genoa, Italy.

Born in 1961. M.D., University of Bologna, Ph.D. in Neuroscience, University of Parma. Senior Researcher at the University of Parma since 1992. He is actually Professor of Human Physiology at the University of Ferrara and Senior Researcher at the Italian Institute of Technology. He has a long experience in electrophysiology and neurophysiology in monkeys (single-neuron recordings) and humans (transcranial magnetic stimulation, study of spinal excitability, brain imaging, recording of single neurons in awake neurosurgery patients).

Among his contributions:
The description of the functional properties of the monkey ventral premotor cortex. During this time Fadiga, together with his Parma colleagues, discovered mirror neurons,  a class of neurons that respond both when the monkey performs actions and when it observes similar actions made by other individuals. Fadiga has suggested that these neurons unify perception and action and may contribute to others' action understanding (Experimental Brain Research, 1992; Brain, 1996; Cognitive Brain Research, 1996).
The first demonstration that a mirror system exists also in humans. He achieved this result by applying transcranial magnetic stimulation (TMS) on the hand motor cortex of human subjects while they were observing others' actions. He demonstrated that the amplitude of observer's hand muscle potentials, as evoked by TMS, was specifically and significantly modulated by the observed actions (Journal of Neurophysiology 1995).
The study of peripersonal space representation in monkey premotor cortex (Science, 1997).
The demonstration that a similar motor resonance is activated during speech listening and involves tongue-related motor centers (European Journal of Neuroscience, 2002). He recently further demonstrates that this motor activation evoked by speech listening is functional to speech perception. This result shows for the first time a causal relationship between action representation and perception (The motor somatotopy of speech perception, Current Biology, 2009).
The first demonstration that, in humans, the frontal area for speech production (Broca's area) is almost constantly activated by action observation (by several brain imaging experiments carried out in collaboration with San Raffaele Hospital of Milan, USC and UCLA of Los Angeles, HUT of Helsinki, Juelich Brain Imaging Center, Royal Holloway University of London) (Experimental Brain Research 1996).
The very recent demonstration that Broca's area activation reflects a primary role played by this area in pragmatically understanding actions of others (Brain, 2009).

Fadiga is currently leading a group of researchers at the University of Ferrara. He is coordinating a project on neuro-rehabilitation of stroke patients by action observation. He is leading a group of researchers at the Italian Institute of Technology to investigate the possibility to establish hardware communication between the human brain and some artificial device (brain-machine interfaces). Other fields of his research concern attention and its neural mechanisms in normal subjects and patients. He has been involved in RobotCub, CONTACT, and Poeticon EU projects, he is currently working in Siempre and Poeticon++ EU Projects. He is interacting with roboticists in order to perform experiments on artefacts that would never be possible in living subjects. Within EU-IST, he is a strong supporter of the emerging cultural domain which is neurorobotics.

Fadiga is reviewer of many international neuroscience journals, he was principal investigator in CNR projects on reaching-grasping, he directs several European Projects on action and speech recognition and control, he was co-investigator in Human Frontier Science Program and McDonnel-Pew funded projects, he has published more than 100 peer-reviewed publications in international journals. His work has received about 35,000 citations (H-Index, 56. Source: Google Scholar. Luciano Fadiga has been member and Chair of the SH4 Panel (Starting and Consolidator Grants) of the European Research Council (ERC).

References
Europe's Information Society, IST Event 2006
RoboCub Project, list of published papers
A recent review by Pulvermueller and Fadiga on sensorimotor grounding of language (Nature Reviews in Neuroscience, 2010)

External links
IIT Website

1961 births
University of Bologna alumni
University of Parma alumni
Italian physiologists
Living people
Italian neuroscientists
Neurophysiologists


text:
Аджма́н () — місто в Об'єднаних Арабських Еміратах, адміністративний центр емірату Аджман.

Місто розташоване на березі Перської затоки за декілька кілометрів від міста Шарджа, утворюючи разом з Шарджею і Дубаєм агломерацію з населенням близько 3 млн осіб. Населення власне Аджмана — 225 тисяч осіб (2003): це 5-е за кількістю населення місто в ОАЕ.

З давніх-давен воно прославилося як центр риболовецького промислу в регіоні, а також видобутком перлів, проте до недавнього часу було невеликим містечком. Лише останнім часом місто стало швидко зростати завдяки бурхливому розвитку прилеглих мегаполісів — Дубая та Шарджі. У місті розташований морський порт. Аджман відомий своїми верфями, на яких дотепер за старовинними технологіями виробляють традиційні арабські вітрильники дхау та найсучасніші склопластикові суду.

Місто знамените своїм Національним історичним музеєм з експозицією археологічних знахідок, манускриптів та зброї. Також можна відвідати квадратну сторожову вежу, мечеть Аль-Нуамі, трек для верблюдячих перегонів.

Примітки

Міста Об'єднаних Арабських Еміратів


text:
Q: Change children of StackPanel when StackPanel parent is resizing I have some StackPanels in a Grid. They are filled with Labels (height of all labels > displayable space). A possible XAML would be:
<Grid>
  <StackPanel>
    <Label Content="bla" Background="lime" />
    <Label ...>
    ...
  </StackPanel>
</Grid>

Every time the size of the Grid changes, I need to change the inner content of the StackPanel. I need to hide the overflowing Label that is only shown partly. To achieve this, I can use following solutions: with a Converter and make a new class that is inherited from StackPanel.
I want to create a different way by using an attached property. I have following code:
//DepProp OverflowVisibility (double), can save height value

public static void Initialized(DependencyObject pObject, DependencyPropertyChangedEventArgs e)
{
  var panel = (pObject as Panel) //the StackPanel in this case
  panel.SizeChanged += panel_updateInnerLayout;
}

static void panel_LayoutUpdated(object sender, EventArgs e)
{
  var parent = sender as Panel;

  if(parent != null)
    foreach(FrameworkElement element in parent.Children)
    {
      var elementPos = element.TransformToAncestor(parent).Transform(new Point(0,0));

      if(element.ActualHeight + elementPos.Y >
        (double)parent.GetValue(OverflowVisibilityProperty))
        element.Visibility = Visibility.Hidden;
      else
        element.Visibility = Visibility.Visible;
    }
}

And an example for usage in XAML:
<Grid>
  <ItemsControl>
    <ItemsPanel>
      <ItemsPanelTemplate>
        <StackPanel own:OverflowVisibility.OverflowVisibility="{Binding Grid height}" />
      </ItemsPanelTemplate>
    </ItemsPanel>
  </ItemsControl>
</Grid>

Every time the StackPanel changes it's size, I can update my labels with the panel_updateInnerLayout event handler. When the size of StackPanel is changed, everything is working fine.
My Problem: The StackPanel itself doesn't raise SizeChanged because it has a bigger height than the Grid. I need an event that raises every time the Grid changes its height.
My Question: Is there any event instead of SizeChanged, that is called every time I change the Grid size? If not, is there an alternative way with an attached property to solve my problem?
I also tried to set a binding of the height of the StackPanel to ItemsControl ActualHeight but it does not raise the SizeChanged.

A: Unfortunately, you have chosen the wrong Panel control for your requirements. The StackPanel should only be used when the resizing of its contents is not required, because it doesn't provide any child control resizing abilities. Therefore, you should use a Grid, or any other Panel that provides resizing abilities. Please refer to the Panels Overview page on MSDN for further help with choosing the appropriate Panel.

A: There are 2 possible events: SizeChanged and LayoutUpdated. SizeChanged doesn't work because the StackPanel is not resized. LayoutUpdated does not work, because the sender of this event is always null and i can not locate what StackPanel was the source.
For more see: Layout Events - SizeChanged and LayoutUpdated.
So there are no possible event available for my approach.
While I searched for a solution, I also found out, that I used the term attached property also for attached behavior and blend behavior. The difference is described here. Summary: properties do nothing with the object but their presence can be used, behaviours change the object behavior. Blend behaviors are behaviors that Microsoft created for Microsoft Blend. The code in my question is attached behavior.
For attached behaviors I didn't found a solution, but for Blend behaviors i found some. You need to add a reference Micosoft.Windows.Interactivity.
After that i used this code:
public class OverflowVisibilityBehavior : Behavior<VirtualizingStackPanel>
{
  protected override void OnAttached()
  {
    AssociatedObject.LayoutUpdated += AssociatedObject_LayoutUpdated;
    base.OnAttached();
  }

  protected override void OnDetaching()
  {
    AssociatedObject.LayoutUpdated -= AssociatedObject_LayoutUpdated;
  }

  void AssociatedObject_LayoutUpdated(object sender, EventArgs e)
  {
    var parent = AssociatedObject; //that solves the problem: you can get a "sender" information

    //...
    // Instead of property GetValue
    (VisualTreeHelper.GetParent(parent) as ItemsPresenter).ActualHeight
  }
}

Some problems left: The parent of the StackPanel must raise SizeChanged. If you put a StackPanel in a StackPanel in a Grid, you need modify it.
Second: LayoutUpdated changes the StackPanel several times. More times than i need.


Asphalt patching is an important task when it comes to asphalt maintenance. Fixing a pothole will prevent the hole from becoming larger; it will also help prevent any damages to the cars and trucks that drive over the pothole. Whether you're doing a cold patch or a hot asphalt patch, Asphalt Kingdom has the supplies you need for successful asphalt repairs.
Looking for parts and accessories for your patching equipment? We have them in stock and ready to ship! We've got the asphalt patching tools and equipment you need to fill holes in asphalt quickly and professionally. Need to fill cracks in pavement? Visit our Asphalt Crack Repair center.
Not sure what asphalt patching equipment you need? We can help.


Naspers' location-based grocery marketplace Tradus' site down for 'maintenance'; not part of Ibibo anymore?
Tradus.com, a location-based grocery marketplace owned by Naspers which was rumoured to be shutting down last year but came back with a new UI a few months ago, now sports a 'We're under maintenance. We will be back soon' banner on its home page.
The firm's toll free helpline number as well as customer care number are inaccessible, and its apps have also disappeared from the app stores, indicating Naspers has pulled the plug on the venture.
When contacted, ibibo Group's India CEO, Ashish Kashyap, said, "I am not associated with Tradus and I wouldn't comment on that."
ibibo was the umbrella for several consumer internet businesses of Naspers. These straddled various travel related ventures such as Goibibo, redBus.in (acquired in 2013) and travelboutique (B2B online travel platform).
Over the last two years Naspers has consolidated its India business by restructuring its association with Tencent where the online gaming business went to the Chinese firm; PayU India was hived off and brought under the global payment solutions business and it sold its auto classifieds business Gaadi.com to CarDekho.
Tradus was the only non-travel related internet venture under ibibo. We noted that Tradus is no longer mentioned as part of ibibo nor does it show up as a business of Naspers in its global site.
An email sent to South African media and internet ventures giant Naspers on the status of Tradus did not immediately elicit a response.
Notably, Tradus was operating in a space which has been under consolidation with Godrej Nature's Basket acquiring EkStop recently. BigBasket had raised fresh funding last year and seems to be the top player in its space where city-based online grocers are trying to make a space for themselves.
Tradus was previously a horizontal marketplace and later pivoted to become a hyper-local grocery and food products marketplace.
Last September, Mudit Khosla who was the CEO of Tradus.com, had reportedly quit the company.
Naspers also happens to be one of the key backers of Flipkart, India's largest e-com platform, as a minority shareholder.


text:
package com.xeiam.xchange.btcchina.dto;

import com.fasterxml.jackson.annotation.JsonProperty;

/**
 * @author David Yam
 */
public class BTCChinaID {

  private final String id;

  /**
   * Constructor
   *
   * @param id
   */
  public BTCChinaID(@JsonProperty("id") String id) {

    this.id = id;
  }

  public String getId() {

    return id;
  }

  @Override
  public String toString() {

    return String.format("BTCChinaID{id=%s}", id);
  }

}

redpajama_set_name: RedPajamaGithub


text:
Kelly Corrigan Wonders - Live From College
Wednesday Evenings at 8 p.m. in December 2022 & January 2023
December 7, 2022 | 8 p.m. - 9 p.m.
As a parent writing a whole lot of tuition checks, Kelly came to the conversation with a long list of questions. What's the best college can be? What's a typical experience? Who gets the most out of campus life? What's the link between education and democracy? What's fair to expect and why on Earth is it so damn expensive? Andy Delbanco of Columbia has thought, talked and written as much about the value of a liberal arts education as anyone. This is the kick off to the Live From College Road Trip series where Kelly and her producer Tammy sit in on classes and talk to kids on 15 college campuses across the country.
Live From College: College Considerations with Columbia's Andy Delbanco
Travel with the team from Yale to Harvey Mudd, Notre Dame to Tulane, UCSD to Georgetown.
December 14, 2022 | 8 p.m. - 9 p.m.
One of the most popular professors at Boston College is a woman named Biz Bracher. She teaches a course that wonders about ethics, society and the individual. She asks her students to think hard about their potential as citizens and contributors. She drills down on the biggest questions we face: What am I good at? Who am I called to become?
Live From College: College Talk with Boston College's Biz Bracher
This is a conversation that serves all of us, whether we're kids inching toward adulthood or adults craving some productive introspection.
College Visit with Yale's Miroslav Volf - Yale offers a class called Life Worth Living, taught in part by an irresistible religion professor named Miroslav Volf, who has pulled readings from the ages into a curriculum that asks students to reflect on what makes a life "good." As Miroslav says, "we've become experts at means but amateurs at ends."
Live From College: College Visit with Yale's Miroslav Volf
This is a conversation to share with everyone in your immediate circles.
Exhausting, illuminating, filled with grace—that's how the Notre Dame students in this episode described their college experience. In addition to talking to the kids, Kelly sat down with two professors who love their work, Kathy Cummings (winner of the 2021 Excellence in Teaching award) who teaches history and Dr. Sam Newlands, a philosopher who studios hope, optimism and transformative experiences.
Live From College: College Visit with Notre Dame's Kathy Cummings and Sam Newlands at Notre Dame
This is a conversation for anyone wondering about the benefits of studying history and philosophy in an algorithmic world more automated by the day.
January 4, 2022 | 8 p.m. - 9 p.m.
It's easy for academia to become remote, unless you have a professor like Dr. Marcia Chatelain. She teaches history at Georgetown and spends a lot of her classroom minutes creating connections between way back then and right this minute and, as importantly, them and us.
Live From College: Learning How to Learn with Dr. Marcia Chatelain
Dr. Chatelain is a Pulitzer Prize winner who isn't afraid to claim her place as a Den Mother. For those reasons and more that you'll hear, Marcia is one of Kelly's all-time favorite guests.
January 11, 2022 | 8 p.m. - 9 p.m.
Santa Barbara has one of the best community colleges in the country. Kelly and her producer Tammy spent a day on the campus of Santa Barbara City College sitting in on class and talking about books, poetry, identity and society with Dr. Clara Oropeza.
Live From College: The Things You Learn When You Talk about Books with Dr. Clara Oropeza
Dr. Clara Oropeza describes her own intellectual awakenings in a way that helps underline the real point of college.
How do kids become adults who can give and receive feedback? Who approach problems from multiple angles as a matter of course? Who feel safe sharing failures and asking for help? Maybe one way is by taking a class from Dr. Zach Dodds!
Live From College: ...with a Jolly, Brilliant Computer Science Professor Named Zach Dodds
Dr. Dodds is a computer science professor at Harvey Mudd College, who is as enthusiastic about education and supporting the next generation as anyone Kelly has ever spent time with.
Dr. Waded Cruzado was the first person in her family to go to college. She loved it. She went on to get a PhD and move from Puerto Rico to — of all places — Bozeman Montana, where she is regarded in heroic terms.
Live From College: Why We Educate Our Country with the President of Montana State University
Dr. Cruzado is determined to show every kid in the state what's possible around them and within them. Her favorite day of the year is commencement. She is inspired and inspiring in equal measures, and Kelly loved spending time with her.
Support for WVXU is provided by


UNITY CANDLE – Two separate candles are extinguished and one is lit by the husband and wife to indicate the unity of the two separate lives being united together with Christ.
MARRIAGE OF MARY AND JOSEPH.
TURTLE DOVES – The customary offering brought to the temple for a special occasion.
RINGS – signifying the marriage between husband and wife.
FRUIT BEARING TREE – through the sacrament of Marriage, husband and wife are called to bear fruit through the acceptance of God's gift of children.


The Erie Canalway National Heritage Corridor is one of 37 federally designated National Heritage Areas. Its purpose is to help preserve and interpret the historical, natural, scenic, and recreational resources reflecting its national significance and to help foster revitalization of canal-side communities.
Built by Isaiah Wilcox in 1856, according to the trend setting ideas of journalist and phrenologist Orson Fowler, the Wilcox Octagon House is six stories from deep cellar to cupola. The exterior and much of the interior of the house was restored in 1991 and the house is decorated with antiques and artifacts representing the era from 1856–1900. Located less than 3 miles from Sim's Store Museum and the Camillus Erie Canal Park, a visit to both sites makes for a perfect day's outing.
The Camillus area has much of interest both from a historical and a recreational point of view. Please use the links at the left to access information about the history of the town & government, as well as the many local attractions, recreation and entertainment options that are available to residents and visitors alike.
Information about the Finger Lakes Region's wineries, vacation packages, events, real estate and seasonal specials.
The NYS Canal Corporation, a subsidiary corporation under the NYS Thruway Authority, is responsible for the operation, maintenance and promotion of four historic canals that span 524 miles across NYS.
The Erie Canal Museum (ECM) is a private, nonprofit corporation founded in 1962. It is housed in the 1850 Weighlock Building, where canal boats were weighed during the days when they traveled through the center of Syracuse on the Erie Canal. A gallery full of participatory exhibits gives visitors a look at canal life and promotes hands-on- learning. The Museum has three special exhibits each year that draw on its nationally renowned artifact collection and historical research. Museum tours and specialty programs for all age groups are developed to entertain as well as educate. A variety of school programs are also offered by the Museum.


text:
'use strict';

ticTacToeApp.factory('ticTacToeData', function ($resource, $http, $q) {
    var url = 'http://localhost:4444/';

    function getGames(type, access_token) {
        var deferred = $q.defer();

        $http.get(url + 'api/Games/' + type,
            {
                transformRequest: function (obj) {
                    var str = [];
                    for (var p in obj)
                        str.push(encodeURIComponent(p) + "=" + encodeURIComponent(obj[p]));
                    return str.join("&");
                },
                headers: {
                    'Content-Type': 'application/x-www-form-urlencoded',
                    'authorization': 'Bearer ' + access_token
                }
            })
            .success(function (data) {
                deferred.resolve(data);
            })
            .error(function (data) {
                deferred.reject(data);
            });

        return deferred.promise;
    }

    return {
        register: function (username, password) {
            var deferred = $q.defer();

            $http.post(url + 'api/Account/Register', {
                    Username: username,
                    Password: password,
                    ConfirmPassword: password
                },
                {
                    transformRequest: function (obj) {
                        var str = [];
                        for (var p in obj)
                            str.push(encodeURIComponent(p) + "=" + encodeURIComponent(obj[p]));
                        return str.join("&");
                    },
                    headers: {
                        'Content-Type': 'application/x-www-form-urlencoded'
                    }
                })
                .success(function (data) {
                    deferred.resolve(data);
                })
                .error(function (data) {
                    deferred.reject(data);
                });

            return deferred.promise;
        },
        login: function (username, password) {
            var deferred = $q.defer();

            $http.post(url + 'Token', {
                    username: username,
                    password: password,
                    grant_type: "password"
                },
                {
                    transformRequest: function (obj) {
                        var str = [];
                        for (var p in obj)
                            str.push(encodeURIComponent(p) + "=" + encodeURIComponent(obj[p]));
                        return str.join("&");
                    },
                    headers: {
                        'Content-Type': 'application/x-www-form-urlencoded'
                    }
                })
                .success(function (data) {
                    deferred.resolve(data);
                })
                .error(function (data) {
                    deferred.reject(data);
                });

            return deferred.promise;
        },
        getUsers: function () {
            var deferred = $q.defer();

            $http.get(url + 'api/Users/All')
                .success(function (data) {
                    deferred.resolve(data);
                })
                .error(function (data) {
                    deferred.resolve(data);
                });

            return deferred.promise;
        },
        getScores: function () {
            var deferred = $q.defer();

            $http.get(url + 'api/Scores/Top')
                .success(function (data) {
                    deferred.resolve(data);
                })
                .error(function (data) {
                    deferred.resolve(data);
                });

            return deferred.promise;
        },
        getMyGames: function (access_token) {
            return getGames('MyGames', access_token);
        },
        getAvailableGames: function (access_token) {
            return getGames('AvailableGames', access_token);
        },
        getJoinedGames: function (access_token) {
            return getGames('JoinedGames', access_token);
        },
        createGame: function (gameName, access_token) {
            var deferred = $q.defer();

            $http.post(url + 'api/Games/Create', {
                    Name: gameName
                },
                {
                    transformRequest: function (obj) {
                        var str = [];
                        for (var p in obj)
                            str.push(encodeURIComponent(p) + "=" + encodeURIComponent(obj[p]));
                        return str.join("&");
                    },
                    headers: {
                        'Content-Type': 'application/x-www-form-urlencoded',
                        'authorization': 'Bearer ' + access_token
                    }
                })
                .success(function (data) {
                    deferred.resolve(data);
                })
                .error(function (data) {
                    deferred.reject(data);
                });

            return deferred.promise;
        },
        joinGame: function (gameId, access_token) {
            var deferred = $q.defer();

            $http.post(url + 'api/Games/Join', {
                    GameId: gameId
                },
                {
                    transformRequest: function (obj) {
                        var str = [];
                        for (var p in obj)
                            str.push(encodeURIComponent(p) + "=" + encodeURIComponent(obj[p]));
                        return str.join("&");
                    },
                    headers: {
                        'Content-Type': 'application/x-www-form-urlencoded',
                        'authorization': 'Bearer ' + access_token
                    }
                })
                .success(function (data) {
                    deferred.resolve(data);
                })
                .error(function (data) {
                    deferred.reject(data);
                });

            return deferred.promise;
        },
        getGameStatus: function (gameId, access_token) {
            var deferred = $q.defer();

            $http.post(url + 'api/Games/Status', {
                    GameId: gameId
                },
                {
                    transformRequest: function (obj) {
                        var str = [];
                        for (var p in obj)
                            str.push(encodeURIComponent(p) + "=" + encodeURIComponent(obj[p]));
                        return str.join("&");
                    },
                    headers: {
                        'Content-Type': 'application/x-www-form-urlencoded',
                        'authorization': 'Bearer ' + access_token
                    }
                })
                .success(function (data) {
                    deferred.resolve(data);
                })
                .error(function (data) {
                    deferred.reject(data);
                });

            return deferred.promise;
        },
        playGame: function (gameId, row, col, access_token) {
            var deferred = $q.defer();

            $http.post(url + 'api/Games/Play', {
                    GameId: gameId,
                    Row: row,
                    Col: col
                },
                {
                    transformRequest: function (obj) {
                        var str = [];
                        for (var p in obj)
                            str.push(encodeURIComponent(p) + "=" + encodeURIComponent(obj[p]));
                        return str.join("&");
                    },
                    headers: {
                        'Content-Type': 'application/x-www-form-urlencoded',
                        'authorization': 'Bearer ' + access_token
                    }
                })
                .success(function (data) {
                    deferred.resolve(data);
                })
                .error(function (data) {
                    deferred.reject(data);
                });

            return deferred.promise;
        }
    }
});


Hip Hip Hooray! Your students have successfully passed the MSSC assessment and they are on their way to receive the MSSC credential! This is a great addition to a student's resume and also their own personal development. Many students may go on to pursue further education or may already have a job lined up, but what about the students that are entering the job market? How can you help them reach that next step to employment?
How does your center connect students that receive the MSSC credential to local employers? Leave your comment below!


VMworld has always been all about technology; it's a time when VMware and its ecosystem can show off the latest tech, talk about future products, and discuss the best ways to utilize and maximize currently available technology. Here are the five technologies you should spend your time investigating, via sessions and the exhibit floor, at VMworld 2017.
VMware and the Cloud. The cloud is the future for many datacenters, and when VMware announced "VMware Cloud on AWS" in October 2016, it was the death knell for a VMware-branded public cloud offering. This was further solidified in May 2017 when VMware announced it will be offering Desktop-as-a-Service (Daas) infrastructure on Microsoft Azure. It should be interesting to ferret out information about how VMware's identity management, management and automation products will work with public clouds and what third-party products can help with these new challenges.
Containers. Containers and DevOps are the hottest topics in IT nowadays, and VMware is embracing them. If you're looking at implementing containers in your company (and if you aren't, you should be), be sure to hit the Photon and vSphere Integrated Containers (VIC) sessions this year, and stop by the booths of vendors pushing container enhancements to VMware core products; I'm willing to bet there will be plenty this year.
OpenStack. OpenStack systems products are continuing to grow as an important player in the cloud OS market, and VMware is embracing it with products like VMware Integrated OpenStack (VIO), which allows you to deploy an OpenStack-based cloud infrastructure in your vSphere environment. If you're looking at starting up and running a private cloud in your datacenter, you need to devote some time researching how to integrate vSphere with OpenStack.
Whatever Companies VMware Acquires. At past VMworld conferences, VMware has made announcements regarding the acquisitions it has made and how these acquisitions will integrate with its existing products. In the past, this has included such notables as AirWatch, Nicira (NSX) and Propero (VDI), which are now integral products in VMware's stables; in fact, they're driving the greenfield growth of the company. With the hypervisor maturing, VMware needs to reach out and grab the next big thing to stay relevant and, with a few notable exceptions (such as vSAN), it's been done through acquisitions.
Dell/VMware Integrated Products. At Dell EMC World this year, a "Dell EMC VDI Complete Solutions" offering was announced. What excited me about this package was its very competitive pricing and the fact that it could be run in-house. At VMworld this year, I expect that Dell, EMC and VMware will be announcing more of this type of packaging.


Purpose: Formation of epiretinal membranes (ERMs) in the posterior fundus results in visual impairment. ERMs have been associated with numerous clinical conditions, including proliferative diabetic retinopathy (PDR), a neovascular disease. Apelin has been identified as a novel angiogenesis contributor. The aim of this study was to investigate the correlation between apelin and ERMs after PDR.
Methods: ERM samples were obtained by vitrectomy from 12 subjects with PDR (aged 57±6 years; duration of diabetes 16±7 years), and 12 subjects with idiopathic ERM (aged 68±5 years). The samples were processed for immunohistochemistry and reverse transcription–PCR (RT–PCR). We also analyzed samples from patients with PDR who received an intravitreal injection of bevacizumab (IVB) before vitrectomy.
Results: The mRNA expression of apelin was significantly higher in the PDR ERMs than in the idiopathic ERMs. Accordingly, immunohistochemical analysis revealed strong expression of apelin in all eight PDR ERMs without IVB, and was double-labeled with glial fibrillary acidic protein antibody (GFAP), platelet endothelial cell adhesion molecule-1 (CD31), cytokeratin (CK) and vascular endothelial growth factor (VEGF) but not with fibronectin. They were mainly located in the adventitia. In contrast, the expression of apelin was lower in the PDR ERMs after IVB and the idiopathic ERMs.
Conclusions: The results showed that apelin was involved in the formation of ERMs and promoted the formation of adventitia, including glial, endothelial, and RPE cells. Bevacizumab blocked the expression of apelin and regressed gliosis and angiogenesis.
Epiretinal membranes (ERMs) involving the macular or perimacular regions can cause a reduction in vision, metamorphopsia, micropsia, or occasionally monocular diplopia. The incidence of ERMs increases with age and may approach 20% of the total population by age 70 . The presence of ERMs has been associated with various clinical conditions, including proliferative diabetic retinopathy (PDR) . The prevalence of ERMs in PDR was reported to be 20% in type 1 diabetes and 5% in type 2 diabetes [3,4]. Histopathological studies showed that ERMs were composed of various cell types such as glial cells, fibroblasts, and endothelial cells [1,5,6,7], but the pathogenic mechanisms are still unknown. However, different peptide factors, including cytokines and growth factors, have been detected in ERMs and vitreous fluid, coincident with ocular diseases such as PDR [5-9]. Because some peptide factors are soluble mediators of angiogenesis, diabetic neovascularization might be caused or aggravated by these factors .
In recent years, apelin signaling has been identified as an important contributor to angiogenesis [10-20]. Apelin is crucial for embryonic vascular development [10-12] and for the postnatal formation of retinal vessels [13-16]. Apelin promotes angiogenesis in vitro and vivo [16-20] and stimulates endothelial cell proliferation, migration, and tube formation in vitro [15,17,18]. The expression of apelin was upregulated during tumor neovascularization, and overexpression was reported to increase in vivo tumor growth [11,19,20]. Consequently, apelin signaling could represent an interesting new therapeutic target during pathological neovascularization [21-24]. Since apelin has been recognized in previous findings as a factor contributing to angiogenesis, and its role has not been examined in PDR, in the present study we examined the expression of apelin and related factors in ERMs obtained from patients with PDR.
This study adhered to the tenets of the Declaration of Helsinki (human subjects) and to the ARVO Statement on human subject research. We received institutional approval from the review committee of the People's Hospital affiliated with Peking University. Informed consent was obtained from each patient to collect samples. Inclusion criteria included (1) younger than 70 years old, (2) absence of renal or hematological diseases or uremia, (3) no administration of chemotherapy or life-support measures, and (4) the fewest possible chronic pathologies other than diabetes. Exclusion criteria included (1) systematic or ocular historical treatment with anti-VEGF therapy, (2) previous ocular surgery, (3) a history of tumor, and (4) a history of other neovascular ocular diseases. The ERMs were surgically removed from consecutive eyes with secondary PDR and idiopathic ERMs as the control subjects, who underwent pars plana vitrectomy and membrane peeling. Samples derived from 12 patients with PDR (aged 57±6 years, duration of diabetes 16±7 years) and 12 patients with idiopathic ERM (aged 68±5 years) were processed for reverse transcription (RT)–PCR and immunofluorescence staining.
In addition, according to the previous treatment in the reported articles [25-29] and our experience [30,31], 1.25 mg/0.05 ml of bevacizumab (Avastin; Genentech, South San Francisco, CA) was injected into the vitreous cavity in eight samples (aged 51±8 years, duration of diabetes 14±7 years) from patients with PDR as preoperative adjunctive therapy 7 days before vitrectomy. A topical antibiotic was prescribed 3 days before the bevacizumab injection. Anesthetic drops were instilled followed by standard surgical preparation with 0.5% povidone-iodine solution and insertion of a sterile lid speculum. Bevacizumab was injected with a sharp 30-gauge needle through pars plana 4.0 mm from the limbus supertemporally or supernasally. All eyes were examined 1 day after injection particularly for the anterior chamber and posterior segment reaction. Topical antibiotic was prescribed to use for 7 days after IVB.
Total cellular RNA was prepared using an extraction reagent (TRIzol; Invitrogen), and 2 μg of retina RNA was converted into cDNA in a total reaction volume of 25 µl, containing 1 µg Oligo (dT), 5µl M-MLV 5× reaction buffer, 1.25 µl dNTP, 25 units Recombinant RNasin Ribonuclease Inhibitor, and 200 units M-MLV reverse transcriptase. The mixture was incubated for 60 min at 42 °C and terminated by heating at 95 °C for 5 min. RT–PCR analysis was performed, as previously described . A volume of 1 μl of each cDNA product from the reverse transcription procedure was used as the template for PCR amplification in a reaction mixture containing PCR buffer (10 mmol/l Tris-HCl, pH 8.3, 50 mmol/l KCl, 1.5 mmol/l MgCl), 0.2 mmol/l dNTPs, a 0.2 mmol/l set of oligonucleotide primers, and 2.5 units Taq DNA polymerase in a final volume of 50μl. cDNA reverse-transcribed from total RNA was amplified by using primers specific for human apelin (sense, 5′-CAC CTC GCA CCT GCT GTA-3′; anti-sense, 5′-GAA CGG GAA TCA TCC AAA C-3′; 119 bp) and human GAPDH (sense, 5′-TTG ACG CTG GGG CTG GCA TT-3′; anti-sense, 5′-TGG AGG CCA TGT GGG CCA TGA-3′; 117 bp). PCR was performed after initial denaturation at 95 °C for 3 min. Each cycle consisted of a heat-denaturation step at 95 °C for 20 s, annealing of primers at either 63 °C (apelin and GAPDH) for 15s, and then polymerization at 72 °C for 15 s. Negative controls for PCR were performed using "templates" derived from RT reactions lacking either reverse transcriptase or total RNA. After 35 cycles, 15 μl of each reaction mixture were electrophoresed on a 10% Tris-borate-EDTA agarose gel and stained with ethidium bromide. Results of mRNA were quantified indirectly using Glyko BandScan (ProZyme, version 5.0, San Leandro, CA) to analyze the grayscale image.
These samples were embedded in optimum cutting temperature compound (Miles Laboratories, Naperville, IL), flash-frozen in liquid nitrogen, and then stored at −80 °C. Routine hematoxylin and eosin (H&E) staining was performed and examined with light microscopy. Frozen sections (6 µm thick) were cut with a cryostat, mounted on 3-aminopropyltriethoxysilane-coated glass slides, and air-dried overnight at room temperature. The sections were fixed sequentially with 4% paraformaldehyde /4% sucrose in PBS (1X; 137 mM NaCl, 2.7 mM KCl, 4.3 mM NaH2PO4, 1.47 mM KH2PO4, pH 7.4; 20 min), washed (3×, PBS), 100% methanol (10 min), and 0.2% Triton-X100 (10 min). Blocking was performed with 10% goat serum/PBS (1 h, 23 °C) to block nonspecific staining. Primary antibodies were diluted into 10% goat serum/PBS and incubated overnight at 4 °C. The following antibody was used: rabbit polyclonal anti-apelin antibody (1:200, No. ab59469; Abcam, Cambridge, MA). For double-labeling immunofluorescence studies, the antibodies were then incubated with a monoclonal mouse antiglial fibrillary acidic protein antibody (GFAP; 1:150 dilution; Zhongshan Goldenbridge Biotechnology, Beijing, China), a monoclonal mouse anti-PECAM-1 (platelet endothelial cell adhesion molecule-1, CD31) antibody (1:150 dilution; Zhongshan Goldenbridge Biotechnology), a monoclonal mouse anti-cytokeratin (CK) antibody (1:150 dilution; Zhongshan Goldenbridge Biotechnology), a monoclonal mouse anti-fibronectin (FN) antibody (extracellular matrix, ECM), (1:150 dilution; Zhongshan Goldenbridge Biotechnology), and a monoclonal mouse anti-VEGF antibody (1:100; No. sc-7269; Santa Cruz, CA). After blocking, the sections were washed (3×, PBS) and then incubated with secondary antibodies diluted in 20% FBS, 10% goat serum, and PBS, respectively (1 h, 37 °C). Secondary antibodies used fluorescein isothiocyanate–conjugated goat anti-mouse-tetramethyl rhodamine isothiocyanate (1:200; No. ZF-0312; Zhongshan Goldenbridge Biotechnology) and cyanogen (CY) 3-conjugated goat anti-rabbit-fluorescein isothiocyanate (1:200 dilution; No. BA1032, Sigma, Carlsbad, CA). The samples were counterstained with 4', 6-diamidino-2-phenylindole (DAPI; 1:1,000; No. D9542, Sigma) and then covered with a non-fluorescent sealant. Immunofluorescence was viewed using a fluorescence microscope (DS-Ri1-U2, Nikon, Japan) and images acquired using a DS-U2u camera with NIS-Elements Imaging Software.
The results were expressed as the means±standard error of the mean (SEM), except as noted. The χ2 test was used to test for significance of the difference between genders in the PDR group and the idiopathic group. Differences between the PDR group and the idiopathic group were estimated with the nonparametric Mann–Whitney rank-sum test and the Student t test when appropriate. The statistical analysis was performed using a commercially available statistical software package (SPSS for Windows, version 17.0, SPSS, Chicago, IL). p<0.05 was considered statistically significant. Experiments were performed at least three times.
Samples derived from 12 patients with PDR ERMs (four women, aged 57±6 years, duration of diabetes 16±7 years) and 12 patients with idiopathic ERM (six women, aged 68±5 years) were processed for RT–PCR and immunofluorescence staining. Age and gender did not vary significantly between the PDR group and the idiopathic group (p>0.05, p>0.05). In addition, 1.25 mg/0.05 ml of bevacizumab was injected into the vitreous cavity as preoperative adjunctive therapy 7 days before vitrectomy in eight samples (aged 51±8 years, duration of diabetes 14±7 years) of the PDR group.
Expression of apelin in ERMs was examined with RT–PCR analysis (Figure 1). mRNA encodings were highly expressed as apelin in patients with PDR. The expression of apelin was detected in 12 of 12 (100%) patients with PDR, but in only four of 12 (33%) control subjects (p<0.001; Figure 1). Semi-quantitative analysis was performed based on the gray scale ratio, which revealed that apelin in the PDR group was 7.81±0.54 versus 0.42±0.30 in the idiopathic group, and showed statistically difference between the two groups (t=4.338, p<0.001).
The ERMs from patients with PDR were composed of densely cellular tissue (Figure 2A) or highly vascularized tissue (Figure 2B) and consisted of cellular components, such as retinal pigment epithelial cells, glial cells, fibroblasts, myofibroblasts, endothelial cells, and other cells. The specimens from control subjects showed the crimped nature of the collagen fibers and the sparse cellular components (Figure 2C).
Immunohistochemical analysis was performed to identify the apelin protein expression in the PDR ERMs and idiopathic ERMs (Figure 3, Figure 4). Strong staining of apelin was detected in the specimens of all fibrovascular membranes from patients with PDR (Figure 3A,D,G, and Figure 4A). No apelin was detected in the idiopathic ERMs (Figure 4D) and weak staining of apelin in the membranes from patients with PDR after intravitreal injection of bevacizumab (Figure 4G); meanwhile, we also found large-caliber vessels and fibroglial tissue in ERMs regressed after intravitreal injection of bevacizumab. In addition, we examined whether apelin is coexpressed with the glial cell-specific marker GFAP. The ERMs after PDR contained a large area composed of glial cells (Figure 4B), and many cells in that area were labeled with anti-GFAP and antiapelin (Figure 4C). Similar results were obtained in experiments with vascular endothelial marker CD31 (Figure 3F), RPE cell maker cytokeratin (CK; Figure 3C), and VEGF (Figure 3I), but anti-fibronectin did not label sites reactive with antiapelin. The antibodies were not expressed in these tissues. No immunostaining was observed in the negative controls, which were performed by substituting the primary antiserum with PBS (Figure 5).
We also found adventitia in the PDR ERMs, which were consistent with other experiments previously reported. Many cell components that highly expressed apelin closely surrounded the newly formed vessels in the ERMs from patients with PDR (Figure 3F). Furthermore, we detected several related factors with dual-color immunofluorescence staining in these specimens. Our results showed that many cell types surround the new vessels, such as retinal pigment epithelial cells (Figure 3C), glial cells (Figure 4C), fibroblasts, and myofibroblasts. Furthermore, ECM with the cell types participated in constituting adventitia (Figure 6). All cells and ECM protein closely surround new vessels to form a microenvironment in which cells secrete growth factors or cytokines that promoted vascular formation, such as VEGF in ERMs from patients with PDR.
The results of the present study showed that the expression of apelin mRNA was significantly higher in the PDR ERMs than in the idiopathic ERMs. In addition, the expression of apelin was strongly positive in ERMs from PDR and coexpressed with glial cell-specific markers, vascular endothelial cells markers, and RPE cell markers but not with FN. Recent findings showed that apelin was implicated in glial and vessel differentiation [14-20] and the expression of apelin was higher in the vascular system, particularly in vascular endothelial cells [18,21], and upregulated at the leading edge of vessel formation . Furthermore, a recent report showed the angiogenic activity of apelin in Matrigel experiments, which indicated apelin was a novel angiogenic factor in retinal endothelial cells . Moreover, in our study, the coexpression of apelin and VEGF in ERMs from PDR suggested that two factors may work together synergistically in angiogenesis and gliosis. From the positive staining of apelin in the endothelial cells, glial cells, and RPE cells, we might infer that the increased apelin was due to local production of apelin, presumably as an autocrine function of the retinal cells.
Recent evidence showed that diabetic retinopathy also affects the glial and neural cells of the retina [33,34]. Retinal glial cells might be associated with retinal dysfunctions such as PDR and DR [35-37]. Reactive changes in glial cells such as an upregulation of GFAP occur early during the course of the disease and precede the onset of overt vascular changes [38,39]. Müller cells are an important constituent of the fibroproliferative tissue formed during PDR  and produce growth factors, which activate vascular endothelial cells [41-43]. The occurrence of ERMs in PDR may contribute to the upregulation of growth factors secondary to the changes in Müller cell function [44,45]. Our study showed that apelin was colocalized with GFAP in ERMs from patients with PDR other than the control subjects. We believe our results indicate that the formation of a mixed cellular microenvironment around the new vessels by glial cell proliferation is a consequence of elevated apelin expression.
In our study, we also confirmed adventitia in the ERMs of PDR. Adventitia plays an important role in the neural network, endocrine system, metabolism, immune regulation, damage repair, and regeneration of tissue. Adventitia participates not only in vascular oxidative stress, inflammation, vascular remodeling, and homeostasis, but also as "initiating factors" in various vascular diseases [46-48]. Adventitia plays an important role in vascular biology, and can differentiate into endothelial cells, smooth muscle cells, and mesangial cells, participate in repairing vascular injury, and cause neointimal lesions [49,50]. Our studies showed that many cell types closely surrounded the new vessels, such as retinal pigment epithelial cells, glial cells, fibroblasts, myofibroblasts, and ECM, and these components highly expressed apelin. These phenomena implied a local microenvironment around new vessels, in which cells secrete angiogenic factors or cytokines, such as apelin, VEGF, promoting vascular formation and stimulating the vascular components released by angiogenic factors. Kidoya et al.  found that apelin upregulated the expression of adhesion molecules and promoted cell aggregation, and this function was not dependent on cell expansion. Thus, we presumed that the formation of a microenvironment around a new vessel might be caused by the ability of apelin.
The mechanism of ERM formation in PDR is still unknown, but the first step is thought to be neovascularization. In this process, many angiogenic factors play an important role [5,7-9,51]. Previous studies have reported that apelin and VEGF have positive synergistic effects, where increased expression of one can contribute to the expression of the other . In previous research, we found that apelin, GFAP, and VEGF mRNA and protein levels were significantly increased in the retinas of diabetic rats . Moreover, apelin induced GFAP and VEGF expression. F13A, a specific antagonist of apelin, suppressed GFAP and VEGF expression in vivo. It is consistent with studies that showed knockout apelin or the APJ gene can inhibit hypoxia-induced cell proliferation; this inhibition is not dependent on the VEGF signaling pathway . We also detected plasma and vitreous concentrations of apelin with and without IVB in patients with PDR . No significant differences were found in vitreous or plasma apelin concentrations between the two groups. The results suggest that apelin may not be directly regulated by VEGF. In this study, we found that bevacizumab decreased the expression of apelin and induced vascular and gliosis regression. Our team also recently reported that apelin is suppressed by bevacizumab in central retinal vein occlusion . Therefore, based on the present findings, it is hard to say by which specific mechanism apelin and VEGF interacted. It seems reasonable to assume that apelin and VEGF may be mutually promoted during the development of DR.
In our experiment, the mRNA expression of apelin was detected in the 12 samples (100%) of the PDR group and in four samples (33%) of the idiopathic ERM group. Although a statistically significant difference (p<0.001) was observed between these two groups, the PCR results were not consistent with the immunofluorescence staining results, which showed negative staining of apelin in the idiopathic ERM group derived from the control subjects and no staining in the negative controls. Negative immunocytochemistry controls used PBS to replace the primary antibody. It could exclude the non-specific staining of the tissues by the second stage reagents, but it could not eliminate the possibility that the primary antibody was bound by non-specific means. Since the tissues from the PDR patient samples varied in their affinity for non-specific antibodies, a proper control would be to replace the primary antibody with a preimmune rabbit or mouse immunoglobulin. The non-specific staining in the first-stage antibodies could influence the immunofluorescence staining results.
It has been reported that apelin plays a role in central and peripheral cardiovascular regulation in conscious rats . Apelin lowers blood pressure via a nitric oxide (NO)-dependent mechanism, and the effect of apelin on blood pressure was abolished in the presence of a NO synthase inhibitor . Many researchers indicated that NO, increased by NO synthase (NOS), played an important role in angiogenesis, which mediated endothelial cell survival, proliferation, migration, and interaction with the extracellular matrix [58,59]. Endothelial nitric oxide synthase (eNOS) is a key enzyme that induces endothelial cells to produce NO, which is regulated by the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signal pathway, which stimulates angiogenesis [60,61]. Recently, our research team found that apelin promoted proliferation, migration, and collagen I expression through the PI3K/Akt signaling pathways in RPE cells . Therefore, NO may be downstream of apelin, and regulated via the PI3K/Akt signaling pathways.
In summary, we found high mRNA expression of apelin in ERMs after PDR. Moreover, immunofluorescence revealed the presence of apelin in the vascular and glial component of ERMs. In addition, intravitreal bevacizumab injections significantly reduced the expression of apelin and regressed vessels and fibroglial tissue in ERMs after PDR. Our results showed that apelin was involved in the formation of adventitia and promoted cell proliferation and angiogenesis of ERMs after PDR, and bevacizumab might be useful in preventing the development of ERMs after PDR.
We appreciate the technical help and advice from Chu LQ at Beijing Shijitan Hospital. This study was supported by National Natural Science Foundation of China (81271027 and 81260152) and an EFSD/CDS/Lilly grant (2127000043).
Margherio RR, Margherio AR. Epiretinal macular membranes. In Principles and Practice of Ophthalmology. 2nd ed. Albert DM, Jakobiec FA, Azar DT, Gragoudas ES. Philadelphia, W. B. Saunders 2000; 2103.
Kasai A, Shintani N, Oda M, Kakuda M, Hashimoto H, Matsuda T, Hinuma S, Baba A. Apelin is a novel angiogenic factor in retinal endothelial cells. Biochem Biophys Res Commun. 2004; 325:395-400.
Kasai A, Shintani N, Kato H, Matsuda S, Gomi F, Haba R, Hashimoto H, Kakuda M, Tano Y, Baba A. Retardation of retinal vascular development in apelin-deficient mice. Arterioscler Thromb Vasc Biol. 2008; 28:1717-22.
Kidoya H, Ueno M, Yamada Y, Mochizuki N, Nakata M, Yano T, Fujii R, Takakura N. Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis. EMBO J. 2008; 27:522-34.
Principe A, Melgar-Lesmes P, Fernández-Varo G, del Arbol LR, Ros J, Morales-Ruiz M, Bernardi M, Arroyo V, Jiménez W. The hepatic apelin system: a new therapeutic target for liver disease. Hepatology. 2008; 48:1193-201.
Jorge R, Costa RA, Calucci D, Cintra LP. Scott IUl. Intravitreal bevacizumab (Avastin) for persistent new vessels in diabetic retinopathy (IBEPE study). Retina. 2006; 26:1006-13.
Moradian S, Ahmadieh H, Malihi M, Soheilian M, Dehghan MH, Azarmina M. Intravitreal bevacizumab in active progressive proliferative diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol. 2008; 246:1699-705.
Rizzo S, Genovesi-Ebert F, Di Bartolo E, Vento A, Miniaci S, Williams G. Injection of intravitreal bevacizumab (Avastin) as a preoperative adjunct before vitrectomy surgery in the treatment of severe proliferative diabetic retinopathy (PDR). Graefes Arch Clin Exp Ophthalmol. 2008; 246:837-42.
Scott NA, Cipolla GD, Ross CE, Dunn B, Martin FH, Simonet L, Wilcox JN. Identification of a Potential Role for the Adventitia in Vascular Lesion Formation After Balloon Overstretch Injury of Porcine Coronary Arteries. Circulation. 1996; 93:2178-87.
Barker SG, Tilling LC, Miller GC, Beesley JE, Fleetwood G, Stavri GT, Baskerville PA, Martin JF. The adventitia and atherogenesis: removal initiates intimal proliferation in the rabbit which regresses on generation of a 'neoadventitia'. Atherosclerosis. 1994; 105:131-44.
Tiani C, Garcia-Pras E, Mejias M, de Gottardi A, Berzigotti A, Bosch J, Fernandez M. Apelin signaling modulates splanchnic angiogenesis and portosystemic collateral vessel formation in rats with portal hypertension. J Hepatol. 2009; 50:296-305.
Eyries M, Siegfried G, Ciumas M, Montagne K, Agrapart M, Lebrin F, Soubrier F. Hypoxia-induced apelin expression regulates endothelial cell proliferation and regenerative angiogenesis. Circ Res. 2008; 103:432-40.
Zhao T, Lu Q, Tao Y, Liang XY, Wang K, Jiang YR. Effects of apelin and vascular endothelial growth factor on central retinal vein occlusion in monkey eyes intravitreally injected with bevacizumab: a preliminary study. Mol Vis. 2011; 17:1044-55.
Tatemoto K, Takayama K, Zou MX, Kumaki I, Zhang W, Kumano K, Fujimiya M. The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism. Regul Pept. 2001; 99:87-92.


CA ANZ wants input from New Zealand CAs on a revised and updated Code of Ethics to apply from June 2019.
The rewritten NZ Code of Ethics will provide clearer, stronger guidance for accountants navigating ethical challenges.
CA ANZ wants members' feedback on the Exposure Draft by 8 February 2019.
The revised NZ Code is proposed to apply from 15 June 2019.
The New Zealand Regulatory Board is proposing to adopt a revised Code of Ethics based on the recently updated International Code of Ethics. The revised Code of Ethics will apply to all CA ANZ members in New Zealand. Members are invited to comment on the Exposure Draft 2018-2 Proposed revision of New Zealand Code of Ethics by 8 February 2019.
Clearer and stronger guidance is being provided to help professional accountants navigate the ethical obligations and challenges they encounter.
The International Ethics Standards Board for Accountants (IESBA) released its revamped Code of Ethics for Professional Accountants (including International Independence Standards) (the Code) in April 2018, and it will apply from June 2019.
The new NZ accounting Code of Ethics has the same fundamental principles of integrity, objectivity, professional competence and due care, confidentiality and professional behaviour but has been restructured and rewritten in a way to make it easier to understand.
"The fundamental principles included in the Code give all professional accountants clear principles to follow in their professional activities, regardless of career stage or type of role," says Kristen Wydell FCA, general manager professional standards at CA ANZ.
In response to this, standard setters in Australia and New Zealand have been updating their respective Codes for CA ANZ members. The key dates are summarised below.
IESBA Code released April 2018, applies from 1 June 2019.
NZICA Code of Ethics was issued for comment in November 2018, with a proposed application date for all NZ resident members from 15 June 2019.
NZAuASB proposed Code of Ethics that will apply to NZ assurance practitioners with a proposed application date from 15 June 2019.
Accounting Professional and Ethical Standards Board Code of Ethics for Professional Accountants (including Independence Standards) proposed application from 1 January 2020.
You can find out more about the proposed changes to the NZ Code of Ethics and have your say here.
Acuity explored more issues around accounting ethics with Clare Payne, EY Oceania Fellow for Trust and Ethics, in the December 2018 magazine.


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Q: Java best practice for casting generics I have the following code:
class ParametrizedObject<T> {...}
...
if (unknownObject instanceof ParametrizedObject) {
  ParametrizedObject casted = (ParametrizedObject) unknownObject;
}

This code triggers a rawtypes warning. Is there a way / best practice to avoid it ?
Note: The class ParametrizedObject is part of a framework, I can't change it.

A: It really depends on what you are doing with the casted object, but if you don't care about the type argument, a wildcard can be used to remove the warning:
if (unknownObject instanceof ParametrizedObject) {
    var casted = (ParametrizedObject<?>) unknownObject;
    ...
}

If you're doing something like setting some internal state that relies on the type argument, then it's not possible to safely do the cast due to type erasure, whereby all type parameters are replaced with Object:
class ParametrizedObject<T> {
    T data;

    void setData(T data) {
        this.data = data;
    }
}

MyClass someObject = ...;
ParametrizedObject<?> casted = (ParametrizedObject<?>) unknownObject;
casted.setData(someObject);  // won't compile

MyClass someObject = ...;
ParametrizedObject<MyClass> casted = (ParametrizedObject<MyClass>) unknownObject;
casted.setData(someObject); // compiles but above cast generates a warning


Related Article What can I do while unemployed?
You've probably heard of a P45 when changing jobs, but what is it?
A P45 is a very important piece of paper given to you by an employer when you finish working for their company. This document is a certificate of your income, PAYE, PRSI and USC paid since the start of the tax year up to the end of your employment.
What is on a P45?
Your P45 is needed to claim a refund of PAYE and/or USC while you're unemployed. It's also needed to claim Jobseeker's Allowance or Jobseeker's Benefit. You're required to give it to your new employer whenever you start a new job, too. Unless you want to get emergency taxed when you start a new job, make sure you hand over your P45 along with your bank details to the new employer. After this, it's up to your employer to sort out the rest. They'll send the P45 to Revenue, who will then calculate how much tax you should be paying, this will depend on how much you earn, and if you've received any social welfare payments while you were unemployed.
Your employer is legally required to issue you with a P45 when you finish work, so if you don't get one, ask, and if you still don't get one, contact your local Revenue office.
For more information look at the Revenue website and the Citizens Information Website.
What can I do while unemployed?


From Esther Dyson's Flickr blog:It's interesting how everything fits together. Mehmet is implementing for both Web pages and RSS feeds a community to use the kind ofattention metadata that Steve Gillmor is writing about in the issue(December) of Release 1.
It's interesting how everything fits together. Mehmet is implementing for both Web pages and RSS feeds a community to use the kind ofattention metadata that Steve Gillmor is writing about in the issue(December) of Release 1.0 that Christina Koukkos and I are currentlyediting.
It's interesting how Esther's Flickr blog is emerging as the repository not only for photos but descriptions and even posts like this one. The resulting metadata combines with the more opaque multimedia forms to create a new cooperating layer of applications. As attention comes to the RSS desktop, I've moved from NetNewsWire to Bloglines and the private beta Rojo, where I followed an RSS search feed created in Bloglines and bubbled up as a new post in my Attention channel within Rojo.
I still use my beta copy of NetNewsWire to archive my feeds for offline use, but Dave Winer's pointer to Mary Hodder's travails produced an immediate comment by Bloglines' Mark Fletcher that pointed Mary at his site to retrieve her lost feed data. All but Bloglines are beta, but together they create a service fabric that, when used carefully in concert, creates a joyous noise.


Relatives of legendary sharpshooter Annie Oakley are offering up a collection of items — including her Stetson hat, guns, letters and photographs — in an auction that one expert says hits the mark for its breadth and sentimental value.
Oakley gained fame in the 1880s and 1890s for her shooting skills as a performer in Buffalo Bill's Wild West show. She died in 1926 at the age of 66, but has remained a pop culture icon.
"The country kind of took her to heart," said Tom Slater, Heritage's director of Americana auctions.
Fort Hood shooter's beard delays court hearing.


Welcome Home's largest fundraiser is back for year #3 and will be better than ever!
Join us for a fun, patriotic evening honoring veterans and raising money to restore lives.
100% of your ticket purchase will directly support our mission to end Veteran homelessness!
Snag your tickets before they're all sold out! You won't want to miss this fun, incredible night giving back to those who've given so much to protect our freedoms!
A special thank you to our confirmed top sponsors: Restoration Eye Care, Veterans United Home Loans, Vessell Bridges Murphy Law, Joe Machens Dealerships, Mortgage Connect, Logboat & Major Brands, Fresh Ideas, and Dave Griggs Flooring America. Additional sponsors will be added soon!


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Iconic Celebrities From The Golden Age That Still Alive – For Them Age Really Is Just A Number
Trending December 15, 2021
Max Baer Jr. – 1937
In case you are an ardent fan of vintage shows on TV, you simply can't miss out on Max Baer Jr. After joining the cast of The Beverly Hillbillies, his portrayal of Jethro Bodine made us fall for him. He was a prominent cast member of the popular show until it went off-air in 1971. In order to avoid enacting similar characters on TV, Max changed his career path and tried his hands at directing and produced movies such as Macon County Line.
Though he couldn't garner much success in his career and grab some good opportunities, the thoughts of a refinance never crossed his mind, and his earnings are more than enough to keep bankruptcy attorneys away. He's 82 at present and we hope the star is not stressing much. After all, it's vital he pays attention to his diet and overall health.
Mr. T – 1952
Mr. T wasn't always blessed with a good fortune. He grew up in a very notorious neighborhood and later even did some work in the Army and as a Bodyguard. Mr. T was then given the role of Clubber Lang in Rocky III, and his financial troubles became history. He has been diagnosed with lymphoma, and we pray that he gets to recover from this obstacle in his life.
Yasmine Bleeth – 1968
She was the 'it' newcomer in Baywatch as Stephanie's hot younger sister, Caroline Holden. From teenage boys to grown men, all had a crush on this voluptuous beauty. Even if she was cast for great movies as well, her career suffered due to her cocaine addiction. She enrolled in a rehab facility to get sober, and fortunately, she did overcome the hurdle that almost ruined her life.
John Madden – 1936
The last time he has coached the NFL was in 1978. Yes, we are talking about former NFL coach and broadcaster John Madden. The last time he was in the broadcast booth was the end of the 2008 season. Yet the name Madden is synonymous with pro football.
John Madden, the Hall of Fame coach for the Oakland Raiders, is now in his eighties. And he enjoys a happy retirement away from the media and limelight. However, his name continues to resonate with the game owing to the name he made for himself.
His personality and voice continue to echo in the hearts of football fans forever who watched him over the years. And now lives his legacy with the Madden video games. Madden is now living a peaceful and happy life in Pleasanton, California, with his wife of over 60 years, Virginia. Here's wishing him many more years of success, health, and happiness.
Barbara Eden – 1931
Barbara Eden caught our fancy with Jeannie's portrayal in the television show, I Dream of Jeannie. The role helped her garner acclamation from several quarters and took her to new heights in her career. She saw her parents getting divorced when she was a child, and that might have won her into some stress. But, Barbara put that all behind and started earning money as a singer. She later studied theater and ventured into the show business.
Barbara didn't take much time to showcase her skills and establish herself as a film and television actress. Before stealing hearts with I Dream of Jeannie, she starred in The Brass Bottle and The Yellow Canary and appeared in How To Marry A Millionaire. With all the wealth she has gathered until now, Barbara leads a life of luxury and comfort.


text:
Posted by Richard Willet - Memes and headline comments by David Icke Posted on 4 January 2022
Milton Keynes to hold large-scale driverless car trial – it's not a 'trial' it's a global agenda
A major trial of driverless cars on the public roads will begin in Milton Keynes later this month.
The Fetch car system, backed by the government and Milton Keynes Council, will allow people to order a car through an app.
The car, which is remotely controlled by an operator, will then be delivered to them.
The company behind the trials says a "safety driver" will also initially be in every vehicle.
"It's driverless but not autonomous," said Koosha Kaveh, the chief executive of Imperium Drive, the company behind the trials.
"There's still a human involved, but they'll be sitting in a control centre controlling the vehicle in the same way you would control a drone."
He said to start with, a safety driver will be present for every journey.
"We're working towards making remote driving safer than normal driving. In normal driving you still have blind spots around you that cause accidents. You also can't anticipate what's coming in terms of traffic, pedestrians, cyclists.
He said the company has computer image algorithms that detect anything that is near the car.
"Our goal is to make remote driving safer than actual driving," he said.
Preliminary trials of the "Fetch" driverless cars have been going on for some time on private land and car parks around Milton Keynes stadium, the home of MK Dons football club.
Their players and staff will be taking part in the trials.
The performance director for MK Dons, Simon Crampton, said driverless vehicles will be especially helpful to players because of the Covid-19 pandemic.
"The biggest thing at the moment is Covid, because we can't start putting players together in cars, particularly with the omicron variant being very contagious.
Read More: Milton Keynes to hold large-scale driverless car trial
Coronavirus Technology UK News #Covid madness #driverless cars #technocracy