Maximum period that can be booked is 30 days. Please enter alternative dates. Rooms come with the garden view. Bathrooms are appointed with a shower, a bidet and towels. All children under the age of 6 may stay for free in an extra bed. Maximum capacity of extra beds in a room is 1. Enter your starting point at least street address and city to receive driving directions to incontri apartament firenze recensioni hotel. Specify the age of a child. Specify the age of children. Based on reviews. Children and extra beds All children under the age of 2 may stay for free in a cot. Route Planner Enter your starting point at least street address and city to receive driving directions to the hotel. This field must not be empty.
Dolci, Animazione e Fantasia Personal blog. Enter your starting point Driving Directions. Who runs Villa Incontri. Maximum capacity of extra beds in a room is 1. Reviews about Villa Incontri Check availability and book. The property stretches for 7 hectares square feet and is enriched with beautiful green meadows, vegetable gardens, a large olive grove with internal olive oil production, the flagship of our area. Le Cirque Catering Caterer. Bea by Florence Visual arts. Three floors with independent entrance. Comfortable in the villa. La Montanina di Montebeni Cafe. Not the Tuscan way!
Villa Incontri - Firenze Villa Incontri is located just 3km from the historic center of Florence, reachable by a walk through the lush hillside, by bicycle, or comfortably by public transport. Villa Incontri is located in the hills of Careggi, famous for the Medici Historic Villas and . La storia di Villa Incontri nasce dalla nobile famiglia dei Marchesi Incontri originaria di Volterra da dove si ramificarono a Siena,Pistoia e murder-in-samarkand.com piena era carolingia Teodorico fu il /10(35). Apartment Accommodation in Florence This is a Preferred Partner property. It's committed to giving guests a positive experience with its excellent service and great value. Staff is soo kind, gave us a map & good restraunts & important informations to travel in Firenze also help us to book a transformation too. Seunga, South Korea Large 2 /10(K). Armonie di Villa Incontri, Firenze. K likes. Email or Phone: Password: Forgot account? Home. Reviews. Photos. Videos. Posts. Events. About. Community. Info and Ads. B&B Recensioni. TripAdvisor Reviews. See more of Armonie di Villa Incontri on Facebook. Log In. or. Create New Account. See more of Armonie di Villa Incontri on Facebook. Log 5/5(89).


text:
Q: Django: ManytoMany w/ extra fields gives back duplicate key error on .create() I am trying to use the following code to create a new entry in my model:
ContactRelation.objects.create(
    lead=True, event=request.event, contact=contact
)

However, I am always running into that error message:

duplicate key value violates unique constraint
  "contacts_contactrelation_pkey" DETAIL:  Key (id)=(14) already exists.

I expected Django to count up pk by itself. pk=14 already exists. If I write,
ContactRelation.objects.create(
    pk=199, lead=True, event=request.event, contact=contact
)

then my entry is successfully created. ContactRelation acts as many-to-many relationship table with extra fields. Do you understand why Django is dealing with pks that way?
class ContactRelation(TimeStampedModel):
    """
    Stores data about individual events the contact interacted with.

    :param event: ForeignKey to the event.
    :type organizer: Event
    :param contact: ForeignKey to the contact.
    :type contact: Contact
    :param lead: If true, contact used the sign up form.
    :type lead: bool
    :param attendee: Contact assigned to ticket as attendee.
    :type attendee: bool
    :param purchaser: Contact made an order for the respective event.
    :type purchaser: bool
    """

    event = models.ForeignKey(
        'events.Event', related_name='contact_relation', on_delete=models.CASCADE
    )
    contact = models.ForeignKey(
        Contact, related_name='contact_relation', on_delete=models.CASCADE
    )
    lead = models.BooleanField(
        verbose_name='Lead', default=False
    )  # Contact who 'Signed Up'
    attendee = models.BooleanField(
        verbose_name='Attendee', default=False
    )  # Contact assigned to ticket
    purchaser = models.BooleanField(
        verbose_name='Purchaser', default=False
    )  # Contact made the order

    class Meta:
        unique_together = [['event', 'contact']]

redpajama_set_name: RedPajamaStackExchange


We have noticed that despite an improvement in the economic fundamentals of the United States as per the robust manufacturing numbers, automobile sales data, and upbeat employment numbers in 2014 many go out of their way to find negatives in every economic report instead of focusing on the relativeness of the data. In other words, are we doing better in these areas than two years ago on an "apples to apples comparison" basis?
But to just pick apart negative aspects of a good econ report because growth isn`t as fast as it could be, or employment isn`t perfect compared to the 1950`s boom is shortsighted and misses the real point of these reports, which is to show the trend in relation to the past six years. The relative improvement in the data over an annual basis compared to the previous three years, two years, and a year ago levels. Is the trend still in place, what is this trend, has a new trend emerged? This is what we are looking for in the data comparisons, and not whether the econ reports are 'perfect'!
I think there are many structural issues behind the participation rate that are much more complex than the simplistic view that there are simply not enough good paying jobs so these workers have given up hope. But regardless, first we have to employ the individuals who are in the job market, and we are doing a pretty damn good job of that right now "relatively speaking" to two years ago when 80k was the norm, remember it is all about 'relative improvement', and not 'relative perfection' in the data.
For instance, these are strengths in the report, these are the weaknesses of the report, but overall the big picture is telling us that this is a good economic report. Versus the trend today is too ignore anything good in an economic report, find a negative, push this angle for all it`s worth, and celebrate one`s 'critical thinking' abilities, and maybe even make a name for oneself in the all-important media landscape.
So you're a rebel, a real devil`s advocate, go against the grain for the sake of going against the grain type individual, yep you found the negative, good for you! But is your analysis the best approximation for what is going on in the world, or has it become second nature to always see the negative in everything that you analyze from a behavioral standpoint?
Have you become conditioned to always see the negative at the expense of missing the bigger picture? By focusing solely on the negative, is your world view the best explanation for what is actually occurring in the world? Has your 'Negativeness' become reflexive and 'lazy intellectualism'?
I don`t know about you but I will sure cheer another 200k plus employment report hitting the wire next month, things are looking up in the economy, and better times are ahead for many Americans! Society and the world is going to move forward, with or without you; it overcomes setbacks and strives to make improvements in progress towards greater goals. Unremittingly stuck in 'Negative Land' may be socially chic, but it sure doesn`t capture what is the essence of human creativity and innovation, and it sure limits possibilities.


The Leadership Team will will work with our Camp Director to lead our camp this summer. They will each possess unique skills and strengths and be required to use them in their positions. They will be creative, outside of the box thinkers, reliable, thoughtful, consistent, hard working, good decision makers and work well as a team and independently when needed. This team will be involved in Counsellor and Support Staff interview day, December 28, 2016. These are 16 week and 10 week positions (early May to late Aug). Staff will be required to live on site at the camp during these months. Each Leadership Team member will be asked to take pictures at camp and share them with the Social Media and Session Coordinator to promote camp. All successful applicants will be required to provide a Police Records Check with Vulnerable Sector Screening.
Kenesserie Camp is an alcohol free, tobacco free and illicit drug free facility. There will be zero tolerance of these substances at camp. To provide our campers with the highest quality care our staff must perform at their very best. If you are not able to adhere to this policy please do not apply to camp.
The Leadership Team will be people that demonstrate that "special something" and possess the the ability to make a difference.
The Camper and Counsellor Care Coordinator(the CCCC) will oversee all aspects of caring for our campers and counsellors. The CCCC will contact all first time camper families to welcome them and answer any questions. Should any camper have special needs the CCCC will meet with the camper parents to develop a plan for success. The CCCC will oversee any campers with special needs. This CCCC will check in with all counselling staff on a daily basis and will participate in daily staff meetings. In May and June this position will be involved in planning and running school field trips. This successful applicant will possess First Aid qualifications and be involved in a Development Social Worker Program, Child and Youth Program, Child Studies Program or a related field.
This Summer Camp Administrator oversees all aspects of running the camp office. They will possess excellent communication skills, specifically related to sharing the feel of camp over the phone, taking messages, finding answers and returning phone calls. It is very important that this person answers all phone calls. They will learn CampBrain, the web-based database used for registration and become literate in all dealings with this program. This is a key part of the job. It includes but is not limited to: tracking all stages of the registration process, helping families navigate our web registration portal, tracking and processing payments, issuing invoices and receipts, corresponding with camper families and preparing bank deposits. They will receive all camp mail, collect all camp receipts and invoices and be in regular contact with the Camp Treasurer. This person will possess a minimum of a G2 driver's licence as they will be required to complete town runs to purchase supplies for or complete bank deposits.
The Program Coordinator is responsible for all program activities at camp. They will demonstrate a good understanding of the importance of camp for the campers. They will demonstrate good understanding of child development. They will have a passion for camp and sharing camp. The successful applicant will understand that campers learn, thrive, develop self confidence, learn to live in a community and learn independence at camp. They will be responsible for planning each day of camp. They will develop a well planned series of theme related events that occur throughout each week. They will be an excellent communicator as they will work alongside other Leadership Team members to explain their ideas and plans. In May and June this position will be involved in planning and running school field trips. They will have strong leadership skills and will be organized and well spoken. They will possess managerial skills as they will be leading a group of staff during various activities.
The Outdoor Education and Leadership Coordinator will be an individual with a strong understanding of nature and the world we live in. They will demonstrate outdoor education skills. The successful applicant will be responsible for the planning and implementing of Rec Camps and the Counsellor In Training Program. They will run Outdoor Education sessions. They will oversee all School Field Trips which includes communicating with teachers, planning each day and ensuring high quality programs are delivered. This individual will work with the Director to create a vision and plan for the Environmental Learning Centre. This individual will inspire staff and campers to connect with nature and express the importance of nature to us as humans. This person would ideally be enrolled in an Outdoor Education program or a related field of study. This individual will oversee the opening and maintenance of the camp pool during May and June. They will possess NLS and First Aid qualifications.
The Social Media and Session Coordinator will have a thorough understanding of a variety of social media channels including but not limited to Facebook, Instagram, Twitter and manage Kenesserie's various social media accounts. This person will seek out opportunities for Kenesserie to take part in a variety of community events. They will work with other Leadership Team members to collect and and organize all pictures taken at camp. They will create an end of week slideshow to be used at closing for each camp session. This person will create an end of summer promotional video using pictures and footage from the summer. They will oversee all sessions run at camp. Sessions will be planned, supplies gathered or purchased and plans compiled in an organized format prior to the start of the camping season. They will work alongside the Program Coordinator to plan and create meaningful sessions that correspond with the weekly themes. These sessions will be quality sessions where campers learn skills, make, create, investigate, think and show. They will be an excellent communicator.
The Health Care Provider will begin working at camp in June and work for 10 weeks. They will organize and prepare the Health Care Centre. They will ensure that all medications are current and in stock. This person will oversee all medical forms submitted by campers and staff. They will oversee all medications in an organized and safe fashion. This person will document meds administered. This person will communicate with parents and kitchen staff regarding food allergies. The Health Care Provider will communicate with the Director on a daily basis regarding any illness or injuries at camp. This person should be in a Nursing Program or related field. They will possess as a minimum Standard First Aid & CPR.
The Head Cook will begin working at camp in June and work for 10 weeks. They will clean and prepare the kitchen to be ready for the summer. They will create healthy menus, order food from the supplier and organize food storage. They will prepare all meals for camp. They will oversee and manage the assistant cooks. The Head Cook will maintain the kitchen and adhere to all applicable standards. They will have cooking experience, especially cooking for large groups. They should be in a Culinary Arts Program or a graduate. They will possess a current Safe Food Handling certificate. The Head Cook position will be a negotiated weekly wage based on experience and education, and is not necessarily required to live on site.
If you feel called to one of these camp staff positions, click here to access our on-line staff applicaiton.


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text:
Tevita Mailau (Sydney, Austràlia, 25 d'abril de 1985) és un jugador de rugbi de l'USAP i de la selecció de Tonga. Anteriorment havia jugat pels Auckland Blues al Super Rugby,i per Auckland a la Copa d'ITM, així com per Stade Montois al Top14.
Mailau Va fer el seu debut per Auckland l'any 2006 en un partit contra els Fiji Warriors a Lautoka. La temporada següent fou cedit a Northland Taniwha jugant onze partits, mentre que la temporada de 2008 alternaria ambdós equips.

L'any 2009 Mailau va fer el seu Super Rugby amb els Blues en un partits contra els Bulls a Pretòria. L'any 2012, després de fer 38 aparicions amb la samarreta dels Blues, va signar amb Stade Montois del Top14, equips amb el qual restaria fins al 2015 que fitxaria per l'USAP de la ProD2. L'any 2015, fou un dels jugadors convocats per la selecció de Tonga per jugar la Copa del Món de Rugbi de 2015.

Referències

Jugadors de la USAP
Jugadors de la Copa del Món de Rugbi de 2015
Esportistes de Sydney
Jugadors de rugbi XV neozelandesos
Jugadors de rugbi XV australians

redpajama_set_name: RedPajamaWikipedia


text:
Dakota Business Lending receives $30 million New Markets Tax Credit
The New Markets Tax Credit program began in 2000 and has allocated $5 billion nationwide this year.
By Business staff
FARGO — Dakota Business Lending, a Fargo-based nonprofit which focuses on providing financing for small businesses in North Dakota, Montana and Minnesota, has been selected to receive $30 million in a New Markets Tax Credit allocation by the United States Department of the Treasury.
Created in 2000 by the Community Renewal Tax Relief Act, the tax credit allocated $5 billion to community development entities throughout the country this year. The goal of the program is to "encourage and jumpstart investment in low-income census tracts to create jobs, bring new opportunities to qualifying areas, and fill a financing gap for transformative projects," a news release from Dakota Business Lending stated.
Dakota Business Lending plans to "fill a financing gap through a process of investing and monetizing tax credits," the release continued.
Among the programs potential partners is the Greater Fargo-Moorhead Economic Development Corporation, which plans to use the funds to finance potential expansion projects across North Dakota.
"While the New Markets Tax Program has been around for a number of years nationally, the Fargo-Moorhead area has had somewhat limited access to this powerful financial tool to support primary-sector business development," Joe Raso, CEO of GFMEDC, stated. "We are pleased to partner with them to leverage our market knowledge of potential expansion projects to demonstrate the type of demand needed to justify a NMTC allocation."
For more information on the program, visit dakotabusinesslending.com/nmtc or contact one of the firm's loan officers.
Related Topics: BUSINESS BRIEFSNORTH DAKOTA
Bankruptcies for North Dakota and western Minnesota for Saturday, January 28
Bankruptcy filings from the past week in all of North Dakota and Becker, Clay, Douglas, Grant, Hubbard, Mahnomen, Norman, Otter Tail, Polk, Traverse, Wadena and Wilkin counties in Minnesota.
Auto review: Return of the compact truck: Maverick small on stature, big on versatility
Already named North American Truck of the Year by a group of Michigan journalists, the Maverick this year adds a more hardcore off-road version, the Tremor. It has upgraded shocks, an extra inch of ground clearance, a heavy-duty transmission cooler and all-terrain tires.
By Barry Spyker
Punk Chef Pizza and Bar in downtown Moorhead announces it is closing
"It's become too much" to keep the eatery open, the owners said in a Facebook message. The last day is Saturday, Jan. 28.
By Helmut Schmidt
What does the future of affordable housing look like in Fargo? Just look at Elliott Place
Host Thomas Evanella talks with Fargo Housing and Redevelopment Authority CEO Chris Brungardt about new affordable housing and a look at projects on the horizon.

redpajama_set_name: RedPajamaCommonCrawl


What makes Finland's schoolchildren so smart?
Spring comes late in Kuopio. It is almost May, but lakes are frozen and horizontal snow blasts the windows. Yet at breaktime, Haapaniemi schoolchildren are playing ice hockey and vigorous ball games. My sons' London primary kept pupils indoors at the first flurry, fearful they'd slip; in Finland, they boot them outdoors until the glass falls below minus 15C.


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bankmark is going to participate at the 42nd International Conference on Very Large Data Bases (VLDB), which takes place from September 5 – 9, 2016 in New Delhi, India.
VLDB is a premier annual international forum for data management and database researchers, vendors, practitioners, application developers, and users. The conference covers current issues in data management, database, and information systems research. Data management and databases remain among the main technological cornerstones of the applications of the twenty-first century. With the emergence of Big Data, data-related technologies are becoming more important than ever before.
Dr. Tilmann Rabl, bankmark's CEO, is going to lead the Workshop on Big Data Open-Source Systems (BOSS) on September 9. Moreover, he is going to give a presentation on the subject "From BigBench to TPCx-BB: Standardization of a Big Data Benchmark" on September 5.
Please feel free contact us, if you would like to meet us at VLDB.


text:
Let Go is het derde studio-album van de Amerikaanse band Nada Surf. Het album kreeg overwegend positieve recensies, en geldt als de best ontvangen release van de groep.

Het nummer Blonde on Blonde werd in 2004 gebruikt voor de speelfilm Sommersturm als soundtrack.

Tracklist
 Blizzard of '77
 The Way You Wear Your Head
 Fruit Fly
 Blonde on Blonde
 Inside of Love
 Hi-Speed Soul
 No Quick Fix
 Killian's Red
 Là Pour Ça
 Happy Kid
 Treading Water
 Paper Boats

Voetnoten

Muziekalbum uit 2002


text:
Home About Dr. Ostrov Select Publications Full List of Publications
1. Ostrov, D. A., J. Krieger, J. Sidney, A. Sette, and P. Concannon. 1993. T cell receptor antagonism mediated by interaction between T cell receptor junctional residues and peptide antigen analogues. J Immunol 150:4277.PMID: 8482836
2. Hansen, T., G. Balendiran, J. Solheim, D. A. Ostrov, and S. Nathenson. 2000. Structural features of MHC class I molecules that might facilitate alternative pathways of presentation. Immunol Today 21:83. PMID: 10652466
3. Melian, A., G. F. Watts, A. Shamshiev, G. De Libero, A. Clatworthy, M. Vincent, M. B. Brenner, S. Behar, K. Niazi, R. L. Modlin, S. Almo, D. Ostrov, S. G. Nathenson, and S. A. Porcelli. 2000. Molecular recognition of human CD1b antigen complexes: evidence for a common pattern of interaction with αβ TCRs. J Immunol 165:4494. PMID: 11035089
4. Ostrov, D. A., W. Shi, J. C. Schwartz, S. C. Almo, and S. G. Nathenson. 2000. Structure of murine CTLA-4 and its role in modulating T cell responsiveness. Science 290:816. PMID: 11052947
5. Zhang, W., S. Honda, F. Wang, T. P. DiLorenzo, A. M. Kalergis, D. A. Ostrov, and S. G. Nathenson. 2001. Immunobiological analysis of TCR single-chain transgenic mice reveals new possibilities for interaction between CDR3 α and an antigenic peptide bound to MHC class I. J Immunol 167:4396. PMID: 11591764
6. Ostrov, D. A., M. M. Roden, W. Shi, E. Palmieri, G. J. Christianson, L. Mendoza, G. Villaflor, D. Tilley, N. Shastri, H. Grey, S. C. Almo, D. Roopenian, and S. G. Nathenson. 2002. How H13 histocompatibility peptides differing by a single methyl group and lacking conventional MHC binding anchor motifs determine self-nonself discrimination. J Immunol 168:283. PMID: 11751972
7. Becker, M. N., W. B. Greenleaf, D. A. Ostrov, and R. W. Moyer. 2004. Amsacta moorei entomopoxvirus expresses an active superoxide dismutase. J Virol 78:10265. PMCID: PM516379
8. Eason, D. D., J. P. Cannon, R. N. Haire, J. P. Rast, D. A. Ostrov, and G. W. Litman. 2004. Mechanisms of antigen receptor evolution. Semin Immunol 16:215. PMID: 15522620
9. Hernandez Prada, J. A., R. N. Haire, J. P. Cannon, G. W. Litman, and D. A. Ostrov. 2004. Crystallization and preliminary X-ray analysis of VCBP3 from Branchiostoma floridae. Acta Crystallogr D Biol Crystallogr 60:2022. PMID: 15502315
10. Huentelman, M. J., J. Zubcevic, J. A. Hernandez Prada, X. Xiao, D. S. Dimitrov, M. K. Raizada, and D. A. Ostrov. 2004. Structure-based discovery of a novel angiotensin-converting enzyme 2 inhibitor. Hypertension 44:903. PMID: 15492138
11. Sandberg, E. M., D. VonDerLinden, D. A. Ostrov, P. P. Sayeski. 2004. Jak2 tyrosine kinase residues glutamic acid 1024 and arginine 1113 form a hydrogen bond interaction that is essential for Jak-STAT signal transduction. Mol. Cell. Biochem. 265:161-169. PMID: 15543946
12. Santori, F. R., K. Holmberg, D. Ostrov, N. R. Gascoigne, and S. Vukmanovic. 2004. Distinct footprints of TCR engagement with highly homologous ligands. J Immunol 172:7466. PMID: 15187125
13. Yoder, J. A., R. T. Litman, M. G. Mueller, S. Desai, K. P. Dobrinski, J. S. Montgomery, M. P. Buzzeo, T. Ota, C. T. Amemiya, N. S. Trede, S. Wei, J. Y. Djeu, S. Humphray, K. Jekosch, J. A. Hernandez Prada, D. A. Ostrov, and G. W. Litman. 2004. Resolution of the novel immune-type receptor gene cluster in zebrafish. Proc Natl Acad Sci U S A 101:15706. PMCID: PMC524843
14. Sandberg, E. M., D. VonDerLinden, D. A. Ostrov, P. P. Sayeski. 2005. Identification of cyclohexane-1,2,3,4,5,6-hexabromo- as a small molecule inhibitor of Jak2 tyrosine kinase autophophorylation. J. Med. Chem., 265:161-9.
15. Hernández Prada, J. A., R. N. Haire, M. Allaire, J. Jakoncic, V. Stojanoff, J. P. Cannon, G. W. Litman, D. A. Ostrov. 2006. Ancient Evolutionary Origin of Diversified Variable Regions Revealed by Crystal Structures of an Amphioxus VCBP. Nature Immunol., 7(8) 875-882. PMID: 16799561
16. Litman, G. W., J. P. Cannon, , L. J. Dishaw, R. N. Haire, D. D. Eason, J. A Yoder, J. A. Hernandez Prada, D. A. Ostrov. 2006. Immunoglobulin variable regions in molecules exhibiting characteristics of innate and adaptive immune receptors. Immunologic Research: Perspectives in Immunology. PMID: 17917037
17. Godeny, M. D., J. Sayyah, D. Vonderflinded, M. Johns, D. A. Ostrov, J. Caldwell-Busby, Sayeski, P. P. 2007. The N-terminal SH2 domain of the tyrosine phosphatase, SHP-2, is essential for Jak2-dependent signaling via the angiotensin II type AT(1) receptor. Cell Signal. 19:600-9. PMID: 17027227
18. Ostrov, D. A., C. L. Barnes, L. E. Smith, S. Binns, T. M. Brusko, A. C. Brown, P. S. Quint, S. A. Litherland, D. C. Roopenian, K. A. Iczkowski. 2007. Characterization of HKE2: an ancient antigen encoded in the major histocompatibility complex. Tissue Antigens, 69:181-8. PMID: 17257322
19. Ferreira A.J., J.A. Hernández Prada, D.A. Ostrov, M.K. Raizada. 2008. Cardiovascular protection by angiotensin-converting enzyme 2: a new paradigm. Future Cardiol. 4(2):175-182. PMID: 19804294
20. McDoom, I., X. Ma, D. A. Ostrov, and Sayeski, P.P. 2008. Identification of Tyrosine 972 as a Novel Site of Jak2 Tyrosine Kinase Autophosphorylation and its Role in Jak2 Activation. Biochemistry. 12;47(32):8326-34. PMID: 18636744
21. Ostrov, D. A., J. A. Hernández Prada, P. E. Corsino, K. A. Finton, N. Le, and T. C. Rowe. 2007. Discovery of Novel DNA Gyrase Inhibitors by High Throughput Virtual Screening. Antimicrob. Agents Chemother. 51(10):3688-98. PMCID: PMC2043263
22. Ostrov, D. A., J. A. Hernández Prada, R. N. Haire, J. P. Cannon, A. T. Magis, K. Bailey, and G. W. Litman. 2007. Crystallization and X-ray diffraction analysis of a novel immune-type receptor from Ictalurus punctatus and phasing by selenium anomalous dispersion methods. Acta Crystallogr. Sect F Struct. Biol. Cryst. Commun. Dec 1;63(Pt 12):1035-7. PMCID: PMC2043263
23. Hernandez Prada, J. A., S. L. Madden, D. A. Ostrov, and M. A. Hernandez. 2008. Molecular modeling optimization of anticoagulant pyridine derivatives. J. Mol. Graph Model. Jun;26(8):1365-9. PMID: 18372200
24. Noorwez, S. M., D. A. Ostrov, J. H. McDowell, M. P. Krebs, and S. Kaushal. 2008. A Combinatorial High-Throughput Screening Method for Small Molecule Pharmacological Chaperones of Misfolded Rhodopsin. Invest Ophthalmol Vis Sci. 49(7)3224-3230. PMID: 18378578
25. Hernández Prada J. A., A. J. Ferreira, M. J. Katovich, V. Shenoy, Y. Qi, R. A. Santos, R. K. Castellano, A. J. Lampkins, V. Gubala, D. A. Ostrov, and M. K. Raizada. 2008. Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents. Hypertension. 2008 May;51(5):1312-7. PMID: 18391097
26. Magis, A. T., K. M. Bailey, E. V. Kurenova, J. A. Hernández Prada, W. G. Cance, and D. A. Ostrov, 2008. Crystallization of the focal adhesion kinase targeting (FAT) domain in a primitive orthorhombic space group. Acta Crystallogr Sect F Struct Biol Cryst Commun. Jun 1;64(Pt 6):564-6. PMCID: PMC2496861
27. Cannon J. P., R. N. Haire, A. T. Magis, D. D. Eason, K. N. Winfrey, J. A. Hernandez Prada, K. M. Bailey, J. Jakoncic, G. W. Litman and D. A. Ostrov. 2008. A bony fish immunological receptor of the NITR multigene family mediates allogeneic recognition. Immunity. 29(2):228-37. PMCID: PMC2603606
28. McDoom I., X. Ma, A. Kirabo, K.Y. Lee, D.A. Ostrov, and P.P. Sayeski. 2008. Identification of tyrosine 972 as a novel site of Jak2 tyrosine kinase phosphorylation and its role in Jak2 activation. Biochemistry. 47(32):8326-34. PMID: 18363744
29. Sayyah J., A. Magis, D.A. Ostrov, R.W. Allan, R.C. Braylan, and P.P. Sayeski. 2008. Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth. Mol Cancer Ther. 7(8):2308-18. PMCID: PMC2479271
30. Golubovskaya V.M., C. Nyberg, M. Zheng, F. Kweh, A. Magis, D. Ostrov, and W.G. Cance. 2008. A Small Molecule Inhibitor, 1,2,4,5-Benzenetetraamine Tetrahydrochloride, Targeting the Y397 Site of Focal Adhesion Kinase Decreases Tumor Growth. J Med. Chem. 51(23):7405-7416. PMCID: PMC2662449
31. Ferreira A.J., V. Shenoy, Y. Yamazato, S. Sriramula, J. Francis, L. Yuan, R.K. Castellano, D.A. Ostrov, S.P. Oh, M.J. Katovich, M.K. Raizada. 2009. Evidence for Angiotensin Converting Enzyme 2 as a Therapeutic Target for the Prevention of Pulmonary Hypertension. Am J Respir Crit Care Med. Jun 1;179(11):1048-5. PMID: 19246717
32. Holliday L.S., D.A. Ostrov, T.J. Wronski, C. Dolce. 2009. Osteoclast polarization and orthodontic tooth movement. Orthod Craniofac Res. 12(2):105-12. Review. PMID: 19419453
33. Ostrov D.A., A.T. Magis, T.J. Wronski, E.K. Chan, E.J. Toro, R.E. Donatelli, K. Sajek, I.N. Haroun, M.I. Nagib, A. Piedrahita, A. Harris, L.S. Holliday. 2009. Identification of Enoxacin as an Inhibitor of Osteoclast Formation and Bone Resorption by Structure-Based Virtual Screening. J Med. Chem. 52(16):5144–5151. PMID: 19630402
34. Kurenova E.V., D.L. Hunt, D. He, A.T. Magis, D.A. Ostrov, W.G. Cance. 2009. Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo. J Med Chem. 52(15):4716-24. PMID: 19610651
35. Hochwald S.N., C. Nyberg, M. Zheng, D. Zheng, C. Wood, N.A. Massoll, A. Magis, D. Ostrov, W.G. Cance, V.M. Golubovskaya. 2009. A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer. Cell Cycle. 8(15):2435-43. Epub 2009 Aug 1. PMID: 19571674
36. Zheng D., E. Kurenova, D. Ucar, V. Golubovskaya, A. Magis, D. Ostrov, W.G. Cance, S.N. Hochwald. 2009. Targeting of the protein interaction site between FAK and IGF-1R. Biochem Biophys Res Commun. 388(2):301-5. Epub 2009 Aug 5. PMID: 19664602
37. Corsino P., N. Horenstein, D. Ostrov, T. Rowe, M. Law, A. Barrett, G. Aslanidi, W.D. Cress, B. Law. 2009. A novel class of cyclin-dependent kinase inhibitors identified by molecular docking act through a unique mechanism. J Biol. Chem. 284(43):29945-29955. PMID: 19710018
38. McCormack W., D. Ostrov. 2009. Immunology Team-Based Learning: Receptor Diversity & Antigen Presentation. MedEdPORTAL.
39. Jaiswal A.S., S. Banerjee, H. Panda, C.D. Bulkin, T. Izumi, F.H. Sarkar, D.A. Ostrov, S. Narayan. 2009. A Novel Inhibitor of DNA Polymerase {beta} Enhances the Ability of Temozolomide to Impair the Growth of Colon Cancer Cells. Mol Cancer Res. 7(12):1973-1983. Epub 2009 Dec. 8. PMID: 19996303
40. Cannon J.P., L.J. Dishaw, R.N. Haire, R.T. Litman, D.A. Ostrov, G.W. Litman. 2010. Recognition of additional roles for immunoglobulin domains in immune function. Semin. Immunol. 22(1):17-24. Epub 2009 Dec. 8. PMID: 20004115
41. Graham WV, Magis AT, Bailey KM, Turner JR, Ostrov D.A. 2011. Crystallization and preliminary X-ray analysis of the human long myosin light-chain kinase 1-specific domain IgCAM3. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Feb 1;67(Pt 2):221-3. Epub 2011 Jan 22. PMID: 21301090
42. Jaiswal AS, Banerjee S, Aneja R, Sarkar FH, Ostrov D.A., Narayan S. DNA polymerase β as a novel target for chemotherapeutic intervention of colorectal cancer. PLoS One. 2011 Feb 2;6(2):e16691. PMID: 21311763
43. Xu Z, Vallurupalli A, Fuhrman C, Ostrov D, Morel L. A New Zealand Black-derived locus suppresses chronic graft-versus-host disease and autoantibody production through nonlymphoid bone marrow-derived cells. J Immunol. 2011 Apr 1;186(7):4130-9. Epub 2011 Feb 18. PMID: 21335485
44. Hamazaki T, Leung WY, Cain BD, Ostrov D.A., Thorsness PE, Terada N. Functional expression of human adenine nucleotide translocase 4 in Saccharomyces cerevisiae. PLoS One. 2011 Apr 21;6(4):e19250. PMID: 21532989.
45. Pillai P, Desai S, Patel R, Sajan M, Farese R, Ostrov D, Acevedo-Duncan M. A novel PKC-ι inhibitor abrogates cell proliferation and induces apoptosis in neuroblastoma. Int J Biochem Cell Biol. 2011 May;43(5):784-94. PMID: 21315177
46. Shroads AL, Langaee T, Coats BS, Kurtz TL, Bullock JR, Weithorn D, Gong Y, Wagner DA, Ostrov D.A., Johnson JA, Stacpoole PW. Human Polymorphisms in the Glutathione Transferase Zeta 1/Maleylacetoacetate Isomerase Gene Influence the Toxicokinetics of Dichloroacetate. J Clin Pharmacol. 2011 Jun 3. PMID: 21642471
47. Ucar DA, Cox A, He DH, Ostrov D.A., Kurenova E, Hochwald SN. A Noel small molecule inhibitor of FAK and IGF-1R protein interactions decreases growth of human esophageal carcinoma. Anticancer Agents Med Chem. 2011 Jun 27. [Epub ahead of print] PMID: 21707510
48. Ucar DA, Kurenova EV, Garrett TJ, Cance WG, Nyberg CD, Cox AL, Massoll NA, Ostrov D.A., Lawrence NJ, Sebti SM, Hochwald SN. Disruption of the protein interaction between FAK and IGF-R1 inhibits melanoma tumor growth. Carcinogenesis. 2011 Jul 19. [Epub ahead of print] PMID: 21666222
49. Kulemina LV, Ostrov D.A. Prediction of off-target effects on angiotensin-converting enzyme. J Biomol Screen. 2011 Sep;16(8):878-85. Epub 2011 Aug 22.PMID: 21859683 [PubMed – indexed for MEDLINE]
50. Ostrov D.A., Contag CH. Molecular imaging of inflammation and carcinogenesis. Cancer Prev Res (Phila). 2011 Oct;4(10):1523-6. PMID: 21972077 [PubMed – indexed for MEDLINE]
51. Toro EJ, Ostrov D.A., Wronski TJ, Holliday LS. Rational identification of enoxacin as a novel V-ATPase-directed Osteoclast Inhibitor. Curr Protein Pept Sci. 2011 Oct 25. [Epub ahead of print] PMID: 22044158
52. Michels AW, Ostrov D.A., Zhang L, Nakayama M, Fuse M, McDaniel K, Roep BO, Gottlieb PA, Atkinson MA, Eisenbarth GS. Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation. J Immunol. 2011 Dec 1;187(11):5921-30. Epub 2011 Oct 31. PMID: 22043012 [PubMed – indexed for MEDLINE]
53. Golubovskaya V, Palma NL, Zheng M, Ho B, Magis A, Ostrov D.A., Cance WG. A Small-Molecule Inhibitor, 5′-O-Tritylthymidine, Targets FAK And Mdm-2 Interaction, And Blocks Breast And Colon Tumorigenesis In Vivo. Anticancer Agents Med Chem. 2012 Jan 31. [Epub ahead of print] PMID: 22292771
54. Ezgimen M, Lai H, Mueller NH, Lee K, Cuny G, Ostrov D.A., Padmanabhan R. Characterization of the 8-hydroxyquinoline scaffold for inhibitors of West Nile virus serine protease. Antiviral Res. 2012 Feb 11;94(1):18-24. [Epub ahead of print] PMID: 22343093
55. Haire RN, Cannon JP, O'Driscoll ML, Ostrov D.A., Mueller MG, Turner PM, Litman RT, Litman GW, Yoder JA. Genomic and functional characterization of the diverse immunoglobulin domain-containing protein (DICP) family. Genomics. 2012 Feb 21. [Epub ahead of print] PMID: 22386706
56. Demir A, Oguariri RM, Magis A, Ostrov D.A., Imamichi T, Dunn BM.Kinetic characterization of newly discovered inhibitors of various constructs of human T-cell leukemia virus-1 (HTLV-1) protease and their effect on HTLV-1-infected cells. Antivir Ther. 2012 Mar 20. doi: 10.3851/IMP2090. [Epub ahead of print] PMID: 22436331
57. Golubovskaya VM, Figel S, Ho BT, Johnson CP, Yemma M, Huang G, Zheng M, Nyberg C, Magis A, Ostrov D.A., Gelman IH, Cance WG. A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl) -3, 5, 7-triaza-1-azoniatricyclo [3.3.1.13,7]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo. Carcinogenesis. 2012 Mar 29. [Epub ahead of print] PMC3334519
58. Toro EJ, Zuo J, Ostrov D.A., Catalfamo D, Bradaschia-Correa V, Arana-Chavez V, Caridad AR, Neubert JK, Wronski TJ, Wallet SM, Holliday LS. Enoxacin directly inhibits osteoclastogenesis without inducing apoptosis. J Biol Chem. 2012 Apr 2. [Epub ahead of print PMCID 3366803.
59. Ostrov D.A., Grant BJ, Pompeu YA, Sidney J, Harndahl M, Southwood S, Oseroff C, Lu S, Jakoncic J, de Oliveira CA, Yang L, Mei H, Shi L, Shabanowitz J, English AM, Wriston A, Lucas A, Phillips E, Mallal S, Grey HM, Sette A, Hunt DF, Buus S, Peters B. Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire. Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9959-64. Epub 2012 May 29. PubMed PMID: 22645359; PubMed Central PMCID: PMC3382472.
60. Ucar DA, Kurenova E, Garrett TJ, Cance WG, Nyberg C, Cox A, Massoll N, Ostrov D.A., Lawrence N, Sebti SM, Zajac-Kaye M, Hochwald SN. Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth. Cell Cycle. 2012 Sep 1;11(17):3250-9. Epub 2012 Aug 16. PubMed PMCID346652.
61. Arvan P, Pietropaolo M, Ostrov D. A., Rhodes CJ. Islet autoantigens: structure, function, localization, and regulation. Cold Spring Harb Perspect Med. 2012 Aug 1;2(8). pii: a007658. doi: 10.1101/cshperspect.a007658. PubMed PMCID 3405822.
62. Pompeu YA, Stewart JD, Mallal S, Phillips E, Peters B, Ostrov D.A. The structural basis of HLA-associated drug hypersensitivity syndromes. Immunol Rev. 2012 Nov;250(1):158-66. doi: 10.1111/j.1600-065X.2012.01163.x. PubMed PMID: 23046128.
63. Herzog, RW, Ostrov D.A. Immunology. A decorated virus cannot hide. Science. 2012 Nov 9; 338 (6108): 748-9. Doi: 10.1126/science.1230342. PubMed PMID: 23139318.
64. Martino A.T., Basner-Tschakarjan E., Markusic D.M., Finn J.D. Hinderer C., Zhou S., Ostrov D.A., Srivastava A., Ertl H.C., Terhorst C., High K.A., Mingozzi F., Herzog R.W. Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cells. Blood. 2013 Mar 21; 121 (12): 2224-33. doi: 10.1182/blood-2012-10-460733. Epub 2013 Jan 16. PubMed PMID: 23325831.
65. Salvador L.A., Taori K., Biggs J.S., Jakoncic J., Ostrov D.A., Paul V.J., Luesch H. Potent elastase inhibitors from cyanobacteria: structural bases and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells. J Med Chem. 2013 Fe 14; 56 (3): 1276-90. doi: 10.1021/jm3017305. Epub 2013 Jan 28. PubMed PMID: 23350733.
66. Golubovskaya, V.M., Ho B., Zheng M., Magis A., Ostrov D.A., Morrison C., Cance W.G. Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth. BMC Cancer. 2013 Jul 11; 13(1):342. PMC3712010.
67. Leung, W.Y., Hamazaki T., Ostrov D.A., Terada N. Identification of adenine nucleotide translocase 4 inhibitors by molecular docking. J Mol Graph Model. 2013 Sep;45:173-9. Epub 2013 Sep 4. PubMed PMID 24056384.


Items Tagged with "Kelley Barracks"
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text:
Air Chief Marshal reiterates effective utilisation of resources for operational readiness
Last Updated: Mon, Oct 29, 2018 23:21 hrs
[India], Oct. 29 (ANI): The Chief of the Air Staff, Air Chief Marshal BS Dhanoa on Monday reiterated effective utilisation of available resources for operational readiness at all times.
In his opening address at the inauguration event of the Maintenance Command Commanders' Conference at Vayu Sena Nagar, Nagpur, the Air Chief said that the Maintenance Command has a major role in maintaining the warfighting equipment of the Indian Air Force (IAF) and urged them to keep pace with the rapid upgradation of modern technologies being incorporated into the defence system.
Congratulating the field commanders for excellent performance and quality output is given by all the Base Repair Depots (BRDs) and Equipment Depots (EDs) during Exercise Gagan Shakti, Air Chief Marshal Dhanoa appreciated the effort of the depots for boosting the serviceability of aircraft, radars and SAGW during the exercise.
The Air Chief Marshal also presented trophies to Base Repair Depots and Equipment Depots that had excelled in their core professional work.
The two-day conference was attended by the Commanders of Base Repair Depots, Equipment Depots and other units/stations under Maintenance Command.
The progress of various on-going maintenance activities and projects at various units was reviewed during the conference.
Defence Public Relation Officer, Group Captain Basantkumar B Pande informed that the headquarters Maintenance Command has also taken initiative towards renewable energy wherein all major building rooftops are being installed with solar cells. Similar projects are also underway in five other major stations under Maintenance Command.
The Chief of Air Staff inaugurated the Solar Power Plant installed on the rooftop of the Maintenance Command headquarters building that is the first green building in the Maintenance Command and would ensure that the complete energy requirement of the building would be met from the Solar Energy during the conference and thereafter.
After the inauguration of the solar power plant, Air Chief Marshal Dhanoa interacted with all personnel included all Air warriors, civilian Staff, DSC personnel and NCs(E) of HQ MC, IAF.
Earlier in the day, Air Force Wives Welfare Association President Kamalpreet Dhanoa addressed a meeting of Sanginis along with Kusum Sharma, President AFWWA (Regional) and AFWWA Presidents of various units under Maintenance Command. (ANI)