Yes, the trailer is as much a part of the boat as the boat itself. If you're hauling this boat to the lake every weekend, you want to know your trailer is in tip top condition. Inspect the wheels for signs of bearing grease or brake fluid leaks. Check the bunk for wear and tear. Don't worry if you see a little rust; that's completely normal.
A cold start is simply cranking the engine for the first time in 24 hours. Be sure your boat dealer gives you the opportunity to run the boat with a cold start before purchase so that you can listen for any clanking, clicking, or humming noises that might occur upon cranking the engine. If you do hear noises, this is a sign of the oil pressure bleeding off in the engine or other engine issues.
Check the engine oil before buying a used boat by lifting the dipstick. The oil shouldn't have any water separation (an indicator of head gasket problems), should be free of a strong gas smell, and should not be globby or gritty.
Beautiful 2016 Super Air Nautique G21 for sale now at Buxton Marine – your Lewisville Boat Dealer!
We all know the lower the engine miles, the better the boat. However, don't take the screen's reading at face value. Be sure to check the hours before test-driving the boat and then after driving the boat to make sure the odometer is in good working condition and accurately portraying the hours.
Don't assume because some electronics work, that all the electronics will work. Check all buttons and switches before buying a used boat. If some work and some don't, you might be looking at faulty electrical wiring.
For years, used boat buyers have trusted Buxton Marine in Lewisville, Texas when buying a used boat. Each of our boats has undergone a lengthy vetting process so there are no surprises. Come see us today and let us find the perfect used boat in Lewisville for your needs.
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Better Call Saul Season 4 Finale Ending Explained
Jimmy and Mike's respective stories come to some interesting conclusions on the Better Call Saul Season 4 finale ending.
By Alec Bojalad | October 9, 2018 |
The following contains spoilers for Better Call Saul season 4 episode 10.
What exactly happened during the ending of the Better Call Saul Season 4 finale? Well…this.
The Birth of Saul Goodman
Yes, Jimmy McGill has said the words "Saul Goodman/S'all good, man" before. He said the latter version as early on as the finale of the show's first season. This season he even adopted the pseudonym as part of his illicit burner phone selling business.
But the real show stopping moment of the Better Call Saul Season 4 finale is Jimmy McGill finally making it official. Professionally, he is now Saul Goodman. Not only that, but he may very well be Saul Goodman full stop. This finale, "Winner," takes stock of Jimmy McGill's soul and doesn't find much of Jimmy McGill left.
In its fourth season, Better Call Saul all but abandoned the prospect of combining Jimmy's legal world storyline with Mike's criminal underworld storyline. In fact the two characters met only once in Season 4, back when Jimmy was looking for someone to steal Hummel figurines for him. As a result, the Better Call Saul season 4 finale is really two finales in one. "Winner" features the season end for both Jimmy and Mike. So let's break down exactly what happened in each.
Last week Kim asked Jimmy if he still wanted to be a lawyer after his initial reinstatement hearing didn't go well because the board didn't believe in Jimmy's sincerity. So Kim's plan as it were was to apply for an appeal and have Jimmy dial up his sincerity meter to 11, whether he's pretending or not.
Jimmy spends the entire first year anniversary of Chuck's death at his brother's headstone, pretending to be upset. Inevitably, many notable figures in the legal world stop by as well and see how sincerely upset Chuck's brother is at his passing. Kim and Jimmy also spend tens of thousands of actual dollars to create a wing at a library for Chuck.
The ruse is going well but it just needs one last touch. Jimmy figures out exactly what that is. He'll read the heartfelt letter that Chuck wrote to him at his appeal hearing – the same letter that he read stone-faced while eating his cereal and that caused Kim to weep.
Jimmy steps up to the stand and begins to read the letter but then something amazing happens! Jimmy goes off script. He admits that this was a half-baked ruse to remind the board of his infinitely more competent brother. It's time for him to come clean about his complicated relationship with the larger-than-life Chuck.
Jimmy says, in part:
"This letter is between me and him and it should stay that way. My brother, Chuck – you knew him. He loved me in his own way. He loved me as a brother. He did not love me as a lawyer. All I wanted to do was make him proud. And he was not an easy man to make proud. He could be a real son of a bitch. Chuck was the one who was always right. And usually he was. For a guy like me, I did lousy in school, I lacked ambition, I always cut corners. For me to live up to the standards of Charles McGill…I mean: look at me. I'll never be as moral as him. I'll never be as smart. I'll never be as good. I'll never be as respected. I'll never be Chuck. But I can try."
It's a remarkable speech, and seemingly the emotional catharsis we've been waiting for all season. It makes some board members cry. Hell, it makes Kim cry. Jimmy wraps up in perfect fashion.
"If you decide that I get to be a lawyer, I'll do everything I can to make sure I'll be worthy of the name McGill," he says.
Mere hours later, Jimmy will officially ditch the name McGill and begin his life as Saul Goodman. Peter Gould essentially told us this would happen. If not this season then soon. Jimmy was closer to Saul then ever. It's still shocking that it's actually here.
What happens after Jimmy's hearing is devastating. Kim thought she knew who she was dealing with. She knew that these displays of sincerity were all an act – she even helped set them up. But this final acting job is so disturbingly convincing that Kim realizes she may have been living with a borderline sociopath this whole time.
Jimmy's change in demeanor once he's given his law license back and adopted his Saul Goodman persona is shocking. "Did you see those suckers? That one asshole was crying," Jimmy tells a gobsmacked Kim. Then he calls a clerk getting a legal document for him "sweetheart." Jimmy is unquestionably Saul Goodman now. It happens so quickly that the real question is "when did this happen?" The death of Chuck may have freed Jimmy in ways none of us were expecting. It's possible that from episode one of this season, Jimmy McGill was already fundamentally Saul Goodman. It just wasn't until this final episode that he says the words and signs the requisite documents.
What's Next for Mike?
Mike's story is similarly devastating. Mike doesn't go through a significant change here. He's always been a murderer. In "Winner" he just happens to be forced into a particularly rough one. Werner really thought Mike was his friend. He thought that he could take a four-day break from his job building an underground meth lab for a violent drug lord and then return and everything would be ok because Mike had his back.
Sadly Mike was taking half measures. He didn't do enough to impart to Werner just how SERIOUS this all was. As a consequence, when Mike finally finds Werner waiting for his wife at a local hot spring…he has to kill the man. Not only has Werner escaped to the outside world – he's unwittingly revealed parts of Gus's plan to the Salamancas thanks to a probing phone call from Lalo. Mike takes Werner out to the desert and tries to convince Gus to spare him. Gus is unconvinced. Mike says he'll do the unfortunate deed.
Mike gives Werner the opportunity to call his wife and convince her to take the next flight home. Werner asks Mike if she'll ever know what happened to him.
"There will be an accident on the work site," Mike says. "There will be lawyers, German lawyers. Her questions will be answered."
"Is there no other way, truly?" Werner asks.
Mike says nothing.
"There are so many stars visible in New Mexico. I will walk out there to get a better look."
As Werner walks slowly further into the desert, Mike approaches him from behind and shoots him in the back of the head.
This is all good tragedy and works well enough on its own. It does, however, have another small implication for the greater Better Call Saul/Breaking Bad mythology. In the final scene of Mike's portion of the finale, Gus shows our old friend Gale (hey, Gale!) the unfinished underground meth lab. Gale is astonished with the quality of it all, while Gus is very, very, very cranky. That lab will never be completed and will always represent a certain level of failure for Gus. Regardless, Gale says he can make it work if they're able to find enough ventilation. Now we know that the lab that Walt and Jesse worked in for the better part of two seasons on Breaking Bad was technically unfinished. Maybe that's how that damn fly got in there.
Better Call Saul doesn't usually go for showy or explosive finales. Mike's sad decision and Jimmy finally acknowledging who he is is about as close as we'll get. Fortunately, Better Call Saul Season 5 is already confirmed.
Tags: AMCBetter Call Saul
Alec Bojalad	| @alecbojalad
TV Editor at Den of Geek and Television Critics Association member. Based in Cleveland, Ohio. Very upset about various sporting events.
Read more from Alec Bojalad
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February 26, 2021 | By Alec Bojalad
Better Call Saul Season 5: Bob Odenkirk Puts on His Saul Goodman Game Face

redpajama_set_name: RedPajamaCommonCrawl


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(-) Ferret
(-) Salamander
(-) Lizard
(-) Analgesia
(-) Anesthesia
Thomsen, P. T., Hansen, J. H., Herskin, M. S. 2021. Dairy calves show behavioural responses to hot iron disbudding after local anaesthesia with procaine. Veterinary Record 188(4), 270-276.
Background: The efficacy of procaine as anaesthetic for disbudding of calves is largely unknown. Likewise, information about effect of interval from local anaesthesia to disbudding and the size of the hot iron used is missing...
Sheil, M., Chambers, M., Polkinghorne, A. et al. 2021. Topical application of lidocaine and bupivacaine to disbudding wounds in dairy calves: Safety, toxicology and wound healing. Animals 11(3), 869.
Tri-Solfen® is a combination topical anaesthetic and antiseptic solution containing lidocaine, bupivacaine, adrenaline and cetrimide. Applied to wounds, it is reported to reduce the pain experienced by calves following thermocautery disbudding. While lidocaine and bupivacaine...
Steagall, P. V., Bustamante, H., Johnson, C. B. et al. 2021. Pain management in farm animals: Focus on cattle, sheep and pigs. Animals 11(6), 1483.
Pain causes behavioral, autonomic, and neuroendocrine changes and is a common cause of animal welfare compromise in farm animals. Current societal and ethical concerns demand better agricultural practices and improved welfare for food animals. These...
Espinoza, C., Lomax, S., Windsor, P. 2020. The effect of topical anaesthesia on the cortisol responses of calves undergoing dehorning. Animals 10(2), 312.
Dehorning causes pain and distress to cattle, and there is a need to provide effective and practical analgesia to improve animal welfare. We conducted an experiment to determine the effect of a modified post-operative topical...
Rasys, A. M., Divers, S. J., Lauderdale, J. D. et al. 2020. A systematic study of injectable anesthetic agents in the brown anole lizard (Anolis sagrei). Laboratory Animals 54(3), 281–292.
Anolis lizards have served as important research models in fields ranging from evolution and ecology to physiology and biomechanics. However, anoles are also emerging as important models for studies of embryo development and tissue regeneration...
Frahm, S., Di Giminiani, P., Stanitznig, A. et al. 2020. Nociceptive threshold of calves and goat kids undergoing injection of clove oil or isoeugenol for disbudding. Animals 10(7), 1228.
In this preliminary study, we compared changes in mechanical nociceptive thresholds (MNT) of calves and goat kids injected with clove oil or isoeugenol under the horn bud as a potential, more welfare-friendly alternative to hot-iron...
Mills, P. C., Ghodasara, P., Satake, N. et al. 2020. A novel transdermal ketoprofen formulation provides effective analgesia to calves undergoing amputation dehorning. Animals 10(12), 2442.
There is a critical need to ensure that all cattle undergoing surgical husbandry procedures are provided effective pain relief. Non-steroidal anti-inflammatory drugs (NSAIDs) are most commonly used, and typically are administered by intramuscular (IM) injection...
Saville, J. W., Ross, J. A., Trefz, T. et al. 2020. Development and field validation of lidocaine-loaded castration bands for bovine pain mitigation. Animals 10(12), 2363.
Castration is among the most common management procedures performed in the dairy and beef cattle industries and is mainly performed by surgery or elastic banding. Despite the various benefits of castration, all methods produce pain...
Van der Saag, D., Lomax, S., Windsor, P. A. et al. 2019. Effect of lignocaine and a topical vapocoolant spray on pain response during surgical castration of beef calves. Animals 9(4), 126.
This study assessed the efficacy of pre-operative injected lignocaine and peri-operative topical vapocoolant spray, administered as most practical for incorporation into routine calf castration procedures. Calves were randomly allocated to: (1) sham castration (SHAM); (2)...
Gladden, N., Ellis, K., Martin, J. et al. 2019. A single dose of ketoprofen in the immediate postpartum period has the potential to improve dairy calf welfare in the first 48 h of life. Applied Animal Behaviour Science 212, 19-29.
The welfare impact of birth on newborn calves has rarely been studied. Dystocia in particular may have significant welfare costs for calves. While analgesia is sometimes provided to calves born to difficult parturition by veterinary...
Ede, T., von Keyserlingk, M. A. G., Weary, D. M. 2019. Assessing the affective component of pain, and the efficacy of pain control, using conditioned place aversion in calves. Biology Letters 15(10), 20190642.
Pain in animals is typically assessed using reflexive and physiological responses. These measures allow inferences regarding nociception but provide little basis for conclusions about the affective component of pain (i.e. how negatively the experience is...
Marti, S., Meléndez, D. M., Pajor, E. A. et al. 2019. Effect of a single dose of subcutaneous meloxicam before knife castration alone or combined with hot-iron branding on scrotal healing, inflammatory response, and behaviour in 2-mo-old beef calves over 42 d post procedure. Canadian Journal of Animal Science 99(1), 179-190.
The objective of this study was to evaluate the effect of a single subcutaneous injection of meloxicam on scrotal healing, inflammatory response, and behaviour in castrated or castrated and branded beef calves for 42 d...
Costa, J. H. C., Cantor, M. C., Adderley, N. A. et al. 2019. Key animal welfare issues in commercially raised dairy calves: social environment, nutrition, and painful procedures. Canadian Journal of Animal Science 99(4), 649-660.
Dairy calf welfare concerns are growing and new evidence suggests that the early life environment influences appropriate physical, behavioral, and cognitive development lasting into adulthood. This review highlights key evidence for the impacts of housing...
Bressan, T. F., Sobreira, T., Carregaro, A. B. 2019. Use of rodent sedation tests to evaluate midazolam and flumazenil in green iguanas (Iguana iguana). JAALAS 58(6), 810–816.
This study aimed to evaluate the applicability of rodent behavioral tests to assess the effects of midazolam and flumazenil in green iguanas. Four tests commonly used to assess sedation in rodents—the open field test, forced...
Van der Saag, D., Lomax, S., Windsor, P. A. et al. 2018. Evaluating treatments with topical anaesthetic and buccal meloxicam for pain and inflammation caused by amputation dehorning of calves. PLoS ONE 13(6), e0198808.
To assess the effects of a topical anaesthetic (TA) and buccal meloxicam (BM) on behaviour, maximum wound temperature and wound morphology following amputation dehorning of beef calves, 50 unweaned Hereford calves were randomly allocated to...
Van der Saag, D., White, P., Ingram, L. et al. 2018. Effects of topical anaesthetic and buccal meloxicam treatments on concurrent castration and dehorning of beef calves. Animals 8(3), 35.
The use of pain relief during castration and dehorning of calves on commercial beef operations can be limited by constraints associated with the delivery of analgesic agents. As topical anaesthetic (TA) and buccal meloxicam (MEL)...
de Boyer des Roches, A., Lussert, A., Faure, M. et al. 2018. Dairy cows under experimentally-induced Escherichia coli mastitis show negative emotional states assessed through Qualitative Behaviour Assessment. Applied Animal Behaviour Science 206, 1-11.
Mastitis and associated pain have been identified as a major health and welfare problem affecting dairy cows, however little is known about how cows emotionally experience this illness. Qualitative behaviour assessment (QBA) is a 'whole...
Sutherland, M. A., Larive, J., Cave, V. et al. 2018. Behavioural and physiological responses to clove oil injected under the horn bud of calves. Applied Animal Behaviour Science 204, 29-36.
The aim of this study was to evaluate the acute and longer-term behavioural and physiological responses caused by administering clove oil under the horn bud of calves and compare these with the responses caused by...
Webb, S. J. N., Hau, J., Schapiro, S. J. 2018. Refinements to captive chimpanzee (Pan troglodytes) care: a self-medication paradigm. Animal Welfare 27(4), 327-341.
In an effort to enhance welfare, behavioural management continually refines methods of non-human primate (NHP) care. Chimpanzees (Pan troglodytes) are one of the most cognitively complex captive NHPs and they have been observed to self-medicate...
Fink, D. M., Doss, G. A., Sladky, K. K. et al. 2018. Effect of injection site on dexmedetomidine-ketamine induced sedation in leopard geckos (Eublepharis macularius). Journal of the American Veterinary Medical Association 253(9), 1146-1150.
OBJECTIVE To evaluate whether the sedative effects of a combination of dexmedetomidine and ketamine differed when it was administered IM in a hind limb versus a forelimb of leopard geckos (Eublepharis macularius). DESIGN Randomized crossover...
Gladden, N., McKeegan, D., Viora, L. et al. 2018. Postpartum ketoprofen treatment does not alter stress biomarkers in cows and calves experiencing assisted and unassisted parturition: a randomised controlled trial. Veterinary Record 183(13), 414.
Dystocia is considered painful and stressful for both the dam and the calf, although systematic evidence of this is limited. Few studies have investigated biochemical markers of stress and pain postpartum and whether any adverse...
Chatigny, F., Kamunde, C., Creighton, C. M. et al. 2017. Uses and doses of local anesthetics in fish, amphibians, and reptiles. JAALAS 56(3), 244-253.
Local anesthetics are an integral part of routine pain management in mammals, yet their use is relatively limited in fish, amphibians and reptiles. These animals frequently undergo potentially painful surgical procedures and therefore could possibly...
McCarthy, D., Windsor, P. A., Harris, C. et al. 2016. Effect of topically applied anaesthetic formulation on the sensitivity of scoop dehorning wounds in calves. PLoS ONE 11(9), e0163181.
The post-operative effects of three formulations of topical anaesthetic and a cornual nerve block on the sensitivity of scoop dehorning wounds in calves were compared in two trials. In Trial 1, 21 female Holstein dairy...
Shapiro, S. J., Reamer, L. A., Mareno, M. C. et al. 2014. Providing chimpanzees opportunities to voluntarily participate in their own care: Choice of medications. American Journal of Primatology 76(S1), 73 (37th Meeting of the American Society of Primatologists Scientific Program, Abstract #112).
Captivity often limits a primate's ability to make meaningful choices on a daily basis. Effective captive (behavioral) management programs should provide primates with opportunities to make meaningful choices. In the present study, arthritic chimpanzees were...
Ball, R. S. 2006. Issues to consider for preparing ferrets as research subjects in the laboratory. ILAR Journal 47(4), 348-357.
Successful housing requires knowledge of ferret behaviors including social behavior, eating habits, a general inquisitive nature, and a species-typical need to burrow and hide. Regular handling is necessary to maintain well-being. A ferret health care...


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I Watched 'Da 5 Bloods' and 'Artemis Fowl' on the Same Weekend: Here's What Happened
jmunney	Cinema, Movie Reviews	Artemis Fowl, Chadwick Boseman, Clarke Peters, Colin Farrell, Da 5 Bloods, Delroy Lindo, Eoin Colfer, Ferdia Shaw, Isiah Whitlock Jr., Jasper Pääkkönen, Jean Reno, Johnny Trí Nguyễn, Jonathan Majors, Josh Gad, Judi Dench, Kenneth Branagh, Lara McDonnell, Mélanie Thierry, Nonso Anozie, Norm Lewis, Paul Walter Hauser, Spike Lee, Tamara Smart, Victoria Ngo	1 Comment
CREDIT: David Lee/Netflix; Walt Disney Studios/YouTube Screenshot
Starring: Delroy Lindo, Jonathan Majors, Clarke Peters, Norm Lewis, Isiah Whitlock Jr., Chadwick Boseman, Johnny Trí Nguyễn, Mélanie Thierry, Paul Walter Hauser, Jasper Pääkkönen, Jean Reno, Victoria Ngo
Director: Spike Lee
Rating: R for Sometimes Shocking, Sometimes Not-So-Shocking Graphic Violence
Release Date: June 12, 2020 (Netflix)
Starring: Ferdia Shaw, Lara McDonnell, Tamara Smart, Nonso Anozie, Josh Gad, Colin Farrell, Judi Dench
Rating: PG for Goofy Fantasy Action
Release Date: June 12, 2020 (Disney+)
I was so worried that I was going to spend so much of my time watching Da 5 Bloods bemoaning its lack of a theatrical release. For one thing, the event status of a Spike Lee joint is unavoidably diminished by an at-home debut, and furthermore, I was concerned that even if I was really feeling it, there would be too many distractions fighting for my attention. Regarding the former, I just had to make peace with that fact. As for the latter, I can't tell you the last time a Netflix release pulled me in with such a firm grip and refused to let go. A prologue swoops in hard and fast with real-world contextualizing footage from the Vietnam War era: Man goes to the moon! Muhammad Ali refuses to serve! Riots at the DNC! Nguyễn Ngọc Loan is executed! If you look away for even a second, you're going to miss something essential.


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Come visit us at Lansdowne Street in Bonita Springs and experience it for yourself.
The brick and rich, dark wood interior takes you a thousand miles from Florida as soon as you enter. A veritable museum of Red Sox memorabilia adorns the walls. An endless variety of microbrews and comfort beers hold their own against a wine list forty bottles strong.
Gourmet sandwiches rule the menu. Hearty soups and bountiful, crisp salads are perfect teammates to the Panini and baked brie. We only use fresh ingredients of the highest quality to craft our food. Here at Lansdowne Street you can indulge in authentic New England cuisine in a setting that looks and feels like a Boston pub without ever leaving Bonita Springs.
Lansdowne Street is the only restaurant and bar in Bonita Springs specializing in New England Sports. We've got plenty of televisions and show all the Red Sox, Patriots and Celtics games as they happen. Watch the games the way they do in Boston…with a Fenway-style crowd of like-minded fans cheering on the team.
Food. Drink. Sports. What more could you ask for?
Lansdowne Street is the Red Sox Nation's Southernmost Outpost. This is where you belong.


The work title, Playground Disorder, suggests a playful handling of places and describes an order, which, whatever order it may have been, is brought into disarray. And indeed the two work groups, The house that burns everyday and Crime scenes, both shown in extracts, are a continuance of her work that becomes manifested in her worldwide shown series: The documentation of staged reality.
Contrary to familiar artistic practice the work's creation is not in the artist's hand but discovered and documented without any intervention. Each situation is based on an essential simulation. Although a clear, unaltered image is on display, it demands an explanation. Cleverly Gadonneix's photographs play with the clash of document, simulation and fiction. Deserted places and interiors create a rather disturbing atmosphere in which the line between real objects and fictitious incidents becomes blurred.
Rooms, like a kitchen, living room and a home office blackened by soot appear to be black and white photographs contrasting with a bright red-orange burning bed. Seemingly well-defined pictures, that are neither real nor staged. We see neither living spaces nor furniture – what we see are learnt proportions, attached to hights, depths and design – an illusion of stainless steel and concrete of which grey values are no result of develop processes of photo material but of the prevailing soot. Other realistic arranged spaces guide our gaze from the furniture to yellow eye-catchers that make any functional meaning of the enviroment disappear and direct our concentration onto little details instead.
The meaning behind this radical absurdity emerges as a function of our very own social foundations. We see the bare reality of civilizing evolution, proving grounds for worst-case-scenarios, that take place in this reality just as much as the real catastrophes which they serve to contain.


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Diurnal Group - Efmody set for Swiss launch with EffRx
The European rollout of Diurnal's adrenal franchise is well underway with the availability, in most markets, of Alkindi - a child-friendly hydrocortisone presentation - and now Efmody - a hydrocortisone preparation that mimics the normal physiological release of hydrocortisone. Alkindi is approved for paediatric adrenal insufficiency, including congenital adrenal hyperplasia (CAH), while Efmody is approved for the treatment of adults and adolescents with CAH. With both available, Diurnal now offers improved treatment options for the continuum of patients with adrenal insufficiency, including CAH, from childhood through to adulthood.
The commercialisation of the adrenal franchise in Switzerland started with EffRx and the approval of Alkindi by Swissmedic in 2021. The announcement today extends that agreement to include Efmody. As part of the agreement, EffRx will seek regulatory approval in Switzerland using the clinical data submitted by Diurnal as part of the EMA approval. Submission of the MAA for regulatory review by Swissmedic is expected during H2 2022 with regulatory approval anticipated in 2024. According to the release, there are circa. 450 CAH patients in Switzerland.
As we have already noted, and despite the recent reimbursement setback with SMC, these are still early days for the commercialisation of the company's adrenal franchise targeting disorders such as CAH and adrenal insufficiency (AI), where patients suffer from low levels of cortisol. For the CAH patient, in particular, there is a need for a treatment that mimics the normal physiological release and better addresses the balance between elevated androgens and elevated glucocorticoids while also reducing the risk of life-threatening adrenal crisis.
Currently, Efmody is approved for adolescent and adult CAH in Europe. However, studies are ongoing to take Efmody into AI in Europe with the CHAMPAIN trial (data available end 2022), and in CAH in the US, with the Phase 3 CONnECT study also underway. As data from these studies become available, we anticipate a greater appreciation of the benefit associated with Efmody's circadian delivery of hydrocortisone, particularly in CAH patients, who suffer from a build-up of androgens overnight.


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Economic and Monetary Union of the European Union (EMU)
The economic situation in Europe is very bad, especially in Greece. The animals are particularly vulnerable to economic crises. Try to support the animals in those countries where the economic situation is difficult. Contact the well-established organizations and associations and donate some money. Not all European Union member countries are members of the EMU or use the Euro as currency - EU and EMU are separated in this regard. The euro is the single currency shared by (currently) 17 of the European Union's Member States, which together make up the euro area. The introduction of the euro in 1999 was a major step in European integration.
When the euro was launched on 1 January 1999, it became the new official currency of 11 Member States, replacing the old national currencies – such as the Deutschmark and the French franc – in two stages.
First introduced as a virtual currency for cash-less payments and accounting purposes, while the old currencies continued to be used for cash payments and considered as 'sub-units' of the euro, it then appeared in physical form, as banknotes and coins, on 1 January 2002.
The euro is not the currency of all EU Member States. Two countries (Denmark and the United Kingdom) agreed an 'opt-out' clause in the Treaty exempting them from participation, while the remainder (many of the newest EU members plus Sweden) have yet to meet the conditions for adopting the single currency. Once they do so, they will replace their national currency with the euro.
Sweden meets all the requirements (conditions) to switch to the Euro currency, but Sweden has a referendum opted not to use the Euro as currency in the country.
Which countries have adopted the euro – and when?
1999 Belgium, Germany, Ireland, Spain, France, Italy, Luxembourg, the Netherlands,
Austria, Portugal and Finland
2001 Greece
2002 Introduction of euro banknotes and coins
2007 Slovenia
2008 Cyprus, Malta
2009 Slovakia
The Economic and Monetary Union (EMU) is an umbrella term for the group of policies aimed at converging the economies of members of the European Union in three stages so as to allow them to adopt a single currency, the euro. As such, it is largely synonymous with the eurozone.
All member states of the European Union are expected to participate in the EMU. The Copenhagen criteria is the current set of conditions of entry for states wanting to join the EU.
It contains the requirements that need to be fulfilled and the time framework within which this must be done in order for a country to join the monetary union.
An important element of this is the European Exchange Rate Mechanism ("ERM II"), in which candidate currencies demonstrate economic convergence by maintaining limited deviation from their target rate against the euro.
All member states, except Denmark and the United Kingdom, have committed themselves by treaty to join EMU. Seventeen member states of the European Union, including, most recently, Estonia, have entered the third stage and have adopted the euro as their currency. Denmark, Latvia and Lithuania are the current participants in the exchange rate mechanism. Of the pre-2004 members, the United Kingdom and Sweden have not joined ERM II and Denmark remains in ERM without proceeding to the third stage. The five remaining (post-2004) states have yet to achieve sufficient convergence to participate. These ten EU members continue to use their own currencies.
First ideas of an economic and monetary union in Europe were raised well before establishing the European Communities. For example, already in the League of Nations, Gustav Stresemann asked in 1929 for a European currency against the background of an increased economic division due to a number of new nation states in Europe after WWI.
A first attempt to create an economic and monetary union between the members of the European Communities goes back to an initiative by the European Commission in 1969, which set out the need for "greater co-ordination of economic policies and monetary cooperation," which was followed by the decision of the Heads of State or Government at their summit meeting in The Hague in 1969 to draw up a plan by stages with a view to creating an economic and monetary union by the end of the 1970s.
On the basis of various previous proposals, an expert group chaired by Luxembourg's Prime Minister and Finance Minister, Pierre Werner, presented in October 1970 the first commonly agreed blueprint to create an economic and monetary union in three stages (Werner plan). The project experienced serious setbacks from the crises arising from the non-convertibility of the US dollar into gold in August 1971 (i.e. the collapse of the Bretton Woods System) and from rising oil prices in 1972. An attempt to limit the fluctations of European currencies, using a snake in the tunnel, failed.
The debate on EMU was fully re-launched at the Hanover Summit in June 1988, when an ad hoc committee (Delors Committee) of the central bank governors of the twelve member states, chaired by the President of the European Commission, Jacques Delors, was asked to propose a new timetable with clear, practical and realistic steps for creating an economic and monetary union. This way of working was derived from the Spaak method.
The Delors report of 1989 set out a plan to introduce the EMU in three stages and it included the creation of institutions like the European System of Central Banks (ESCB), which would become responsible for formulating and implementing monetary policy.
EMU - a historical documentation
The three stages for the implementation of the EMU were the following:
Stage One: 1 July 1990 to 31 December 1993
On 1 July 1990, exchange controls were abolished, thus capital movements were completely liberalised in the European Economic Community.
The Treaty of Maastricht in 1992 establishes the completion of the EMU as a formal objective and sets a number of economic convergence criteria, concerning the inflation rate, public finances, interest rates and exchange rate stability.
The treaty enters into force on the 1 November 1993.
Stage Two: 1 January 1994 to 31 December 1998
The European Monetary Institute is established as the forerunner of the European Central Bank, with the task of strengthening monetary cooperation between the member states and their national banks, as well as supervising ECU banknotes.
On 16 December 1995, details such as the name of the new currency (the euro) as well as the duration of the transition periods are decided.
On 16–17 June 1997, the European Council decides at Amsterdam to adopt the Stability and Growth Pact, designed to ensure budgetary discipline after creation of the euro, and a new exchange rate mechanism (ERM II) is set up to provide stability above the euro and the national currencies of countries that haven't yet entered the eurozone.
On 3 May 1998, at the European Council in Brussels, the 11 initial countries that will participate in the third stage from 1 January 1999 are selected.
On 1 June 1998, the European Central Bank (ECB) is created, and in 31 December 1998, the conversion rates between the 11 participating national currencies and the euro are established.
Stage Three: 1 January 1999 and continuing
From the start of 1999, the euro is now a real currency, and a single monetary policy is introduced under the authority of the ECB. A three-year transition period begins before the introduction of actual euro notes and coins, but legally the national currencies have already ceased to exist.
On 1 January 2001, Greece joins the third stage of the EMU.
The euro notes and coins are introduced in January 2002.
On 1 January 2007, Slovenia joins the third stage of the EMU.
On 1 January 2008, Cyprus and Malta join the third stage of the EMU.
On 1 January 2009, Slovakia joins the third stage of the EMU.
On 1 January 2011, Estonia joins the third stage of the EMU.
The European crisis, January 2012


The massive Seward Park development today got a thumbs up from Manhattan Borough President Scott Stringer, DNAinfo reported.
The project, known as the Seward Park Urban Renewal Area (SPURA) plan, will span 1.65 million square feet and make use of the largest swath of undeveloped land below 96th Street. The plan will bring residential, commercial and retail space to a stretch of Delancy Street situated under the Williamsburg bridge.


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Q: How to get result using between clause in mysql query I am new to sql, and i need to get data from DB table using between query.I tried but wont get required result. below is my table structure
EDIT :
I am trying to get interest rate as per the period specified in the query.
If i specify the period as 6 interest rate should be 3 and if even if a specify 11 rate should be 3 only.
suppose if period is 13 then rate should be 4.

    interest table
----------------------------------
id | year | min | max | interest |
----------------------------------
1  | 2019 | 6   | 11  |    3     |
1  | 2019 | 12  | 0   |    4     |

Below query returns me correct interest rate.
SELECT * FROM interest WHERE 6 BETWEEN min AND max AND year=2019

But when i pass value 5 it returns null but still i require result is "interest rate = 3".
and also when i pass 13 i should get result as "interest rate = 4"
but i returns null.
I tried * <= and >=* even that's not working.
where am I going wrong..

A: I you aren't in a position to 'fix' your interest table then you could adjust it by working out the min min value resetting this to 0 and similarly for the max min value
so given your data
    select i.*,
        case when min = (select min(min) from interest) then 0 else min end as minmin,
        case when min = (select max(min) from interest) then 999 else max end as maxmax
from interest i

returns
+------+------+------+------+----------+--------+--------+
| id   | year | min  | max  | interest | minmin | maxmax |
+------+------+------+------+----------+--------+--------+
|    1 | 2019 |    6 |   11 |        3 |      0 |     11 |
|    1 | 2019 |   12 |    0 |        4 |     12 |    999 |
+------+------+------+------+----------+--------+--------+
2 rows in set (0.00 sec)

Which can then be used to check your input value
    select s.*
from
(
select i.*,
        case when min = (select min(min) from interest) then 0 else min end as minmin,
        case when min = (select max(min) from interest) then 999 else max end as maxmax
from interest i
) s
where 5 between minmin and maxmax and year = 2019;

+------+------+------+------+----------+--------+--------+
| id   | year | min  | max  | interest | minmin | maxmax |
+------+------+------+------+----------+--------+--------+
|    1 | 2019 |    6 |   11 |        3 |      0 |     11 |
+------+------+------+------+----------+--------+--------+
1 row in set (0.00 sec)

redpajama_set_name: RedPajamaStackExchange


Life around us is constantly accelerating, and we can hardly keep pace with it. Because of this, most of the active people suffer from sleep problems. Surely even you sacrifice every day 1-2 hours of sleep in order to have time to cope with all the chores. It will just lead to chronic diseases. But modern technology can help you and in this matter sleep trackers are the best. You will find out right now about the most popular ones, and we have in mind not only gadgets but also applications.
First, we'll start with the simplest thing – with sleep trackers that can be installed on smartphones. You probably have already heard that one can easily make basic sleep trackers from them. Now you will get acquainted with three applications, for the work of which only one built-in accelerometer is needed.
All applications, which we will talk about, work on the same principle – the phone must be close to you (preferably on a pillow). During the night accelerometer will read all your movements and determine the phases of sleep – deep and active. But this system is just not ideal for the following reasons: if you sleep next to your spouse or cat, the sensor will fail; if you do not connect your phone to charge, it can be completely discharged during the night; electromagnetic radiation may still have a negative impact on you.
This program will analyze the impact of physical activity, all of your trainings, alcohol, and coffee on the quality of sleep. Every evening before going to bed you will specify in the application, what you did during the day in order Runtastic Sleep Better for a few weeks was able to find a connection between your schedule (way of life) and your sleep. The program is able to monitor the lunar phases as well, to suggest when it is best to go to bed. In the Settings you will be able to find the opportunity to choose an alarm tone, vibration on/off, volume setting, specify the interval at which the alarm will be triggered. By the way, this is the first application in which there is a dream diary.
And this is the second program in our review. Suppose that it has the same ranking in the Google Play store as the previous application, but here more interesting ideas are implemented. There's even an option of alarm reset which is creatively done. In order you definitely to wake up, you will need to disable alarm clock only by the solution of a mathematical problem, either to click on the sheep running around the screen or even take a photo of the QR-code, which is recommended to be put away from your bed. The program has a mode of "lullaby" – you put on headphones and relax by the sounds of the nature. Via the accelerometer, the smartphone will determine, that you have fallen asleep and the melody will subside.
This is another application that is cheaper than competitors, but its rating is slightly higher. In addition to the analysis of sleep and smart alarm clock you can find the function of night sounds recording. Sleep Cycle will be able to distinguish the purring of a cat from your snoring. The rest of the functions are already familiar to us: the analysis of the effect of coffee and eating before going to bed, diary of dreams, moon phases.
Now it is necessary to talk a little about gadgets, which have the function of sleep trackers. The most affordable option is Xiaomi Mi Band. You can easily find the device on sale on AliExpress – the price is less than even $ 10. This bracelet is probably the most popular in the world, let it not even have a heart rate monitor functions. But it is a good idea to count calories, analyze the activity, count your steps, monitor your sleep, and it can also give advice if you stick to a healthy lifestyle. Oh, we almost forgot – bracelet has a record battery life (approximately 720 hours on a single charge). Moreover, Mi Band fits comfortably the wrist, there is a Russified application for smartphones, water-resistant casing. Flaw of the gadget is that it doesn't accurately count the number of steps. However, we are interested in the function of sleep monitoring and this bracelet copes well with it.
Of the more expensive options bracelet Jawbone Up is more often mentioned – it costs a lot, but still it is a sales hit. It is spoken of as the best option for sleep monitoring, but it has just a lot of flaws – poor battery, it often breaks down, the casing is not waterproof. Only all claims are not related to the function which we are talking about in this review.


If you've lined the perimeter of a room with your furniture, and you think this is acceptable — look out, because the design squad might be coming for you.
Don't arrange all your furniture around the edge of a room.
We urge you to think creatively about where to place your sofa, chairs, tables and other pieces of furniture.
But hold on a minute. Before you start lugging furniture back and forth, get yourself a notepad and draw a sketch of your room showing the windows, doors, and any prominent features like a fireplace, large radiators, chandeliers, built-ins, etc. Now experiment with different furniture arrangements using pencil and eraser. Or better yet, make small scale cutouts of your furniture pieces and have fun moving them around.
There are likely many different placements that will work for you, but there are some important pointers to keep in mind.
Before you do anything, stop and ask yourself a few questions about the room. Is it a living room where you hope to encourage friendly conversation? Is it a family room for watching television and spending downtime with loved ones? Or is it a traditional space meant for formal dining or entertaining?
For example, in a living room, you would try to encourage lively conversation, and arrange furniture in a friendly grouping to make it feel inviting for chatting and socializing. This means placing sofas and armchairs no more than five to seven ft. away from each other. If they are any further apart, you and your guests will have to shout at each other to be heard.
Another point to consider is traffic flow. Woe to those who do not pay attention to this important element in a room's design. You will feel as if you are sitting in a movie theatre because your guests will be knocking furniture and each other's knees as they navigate in and out of the space.
A good rule of thumb is that you must allocate anywhere from three to six ft. for paths leading from one room to another.
Another principle to keep in mind is that your furniture arrangement should also include a focal point. For example, it could be a fireplace or a picture window with a view. Or you could create a focal point using a dramatic sculpture on a table, or a large and much-loved piece of art on your wall.
If you are fortunate to have a large room, consider several groupings of furniture — one group might serve as a conversational area while another area might be for reading or watching television.
If you have a small room to furnish, choose compact furniture to help you avoid a claustrophobic feel. In addition, you must accept the scale of the room and avoid stuffing the room with furniture. Remember that in many cases, less is more.
Finally, don't be afraid to take chances. Go ahead and impress your friends with a display of creativity and individuality. Just make sure you follow the rules.


Center for Open Science, Inc.
Knowledge and scientific discovery advances by the transparent communication of ideas and evidence. No individual is the arbiter of truth. All present models of nature are incomplete or incorrect in some way. Scholars propose, challenge, and extend one another's claims via free exchange of evidence. Moreover, the credibility of scientific evidence is established by showing that it is reproducible independent of its originator. This way, scholars individually pursue their curiosities, share their discoveries, and collectively evaluate each other's claims for the advancement of knowledge.
The Center for Open Science's (COS) mission is to increase openness, integrity, and reproducibility of research. COS advances this mission by conducting metascience to understand reproducibility challenges and how to address them, builds infrastructure, provides training, builds community, and nudges incentives across stakeholder communities. Openness is an accelerant to the pursuit of truth. COS provides the means, opportunity, and motivation to pursue openness and ultimately increase the efficiency of discovery.
The focus of this proposal is advancement of the infrastructure and community efforts that will foster a transformative change in research practices toward openness. COS will empower research communities and individuals toward openness by providing technology solutions that make it easy, and shifting incentives to make it desirable. COS will achieve this by scaling its products and services to support open, reproducible research. We will accelerate adoption of open practices, and foster transition of our technology solutions toward a sustainable funding model across the community of stakeholders (funders, institutions, service providers). Success indicators will be evidence of researcher adoption of COS services; open availability of content, process, and outcomes of research; and, growing investment by the stakeholder community to sustain these public goods.


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The Sexual Brain: Neuroscience and sex-related differences
You are here: Home / Cognitive Stimulation News / Brain / The Sexual Brain: Neuroscience and sex-related differences
April 23, 2021 by Cristina Martínez de Toda Leave a Comment
The origin of brain sexuality
It is common knowledge that there are anthropomorphic differences between women and men depending on sex.
Not only are there biological differences between males and females, but recent neuroscience research has also revealed differences between male and female brain structure.
Genetically we are different; females have an XX pair of sex chromosome and males an XY pair, but this has not always been the case. From conception until approximately 8 weeks, circuits start off as female, both in male and female embryos. Only around the eighth week of gestation, dotestes in the male embryo begin to produce and release testosterone, turning female-type brain circuits into male-type brain circuits.
During the first 6 months after birth, there is a marked elevation in testosterone secretion in males. By contrast, girls' ovaries secrete substantial levels of estrogen during the first two years after birth.
Because of these differences, some brain functions are substantially different from childhood.
Key biological factors in sex determination
Sex hormones
Steroid hormones affect gene expression and other cell processes. Thus, they are crucial to the epigenetic effect on the developing brain.
Furthermore, such early interaction with sex steroid hormones during the embryonic period has a vital influence on the expression of subsequent sexual differences in the nervous system.
Sex chromosomes are another key biological factor in sex determination. Females have two X chromosomes while males have one X and one Y chromosome. However, both the X and Y chromosomes contain about 6,500 genes that are expressed differently in men and women in at least one tissue.
Research shows the relationship between sex hormones and chromosomes which, acting together, give rise to the phenotype of a sexually diverse brain.
Neuroscience and sex-related differences
Neuroscience has studied brain volume differences in children, adolescents and adults.
There are specific differences in white matter in all cerebral lobes of men and women.
Fetal testosterone—already discussed earlier—can also predict differences in brain volume in both men and women.
Boys have more gray matter in the posterior lateral orbitofrontal cortex than girls.
The right tempoparietal junction-posterior portion of the superior temporal sulcus and the planumtemporale/parietal operculum are larger in girls than in boys, resulting in areverse effect of fetal testosterone.
The amygdala and hypothalamus are also sexually dimorphic (larger in boys than girls).
Neuroeducation and the sexual brain
Significant differences in brains of men and women have also been shown in the field of neuroeducation.
Autism spectrum disorder (ASD), attention deficit disorder with and without hyperactivity (ADHD), Tourette's syndrome and language disorders, among others, are more common among boys. In fact, boys are four times more likely to be diagnosed with ASD or ADHD than girls.
On the other hand, disorders such as anorexia, depression, and anxiety are more common among girls.
To understand this differentiation, it is essential to understand the concept of temporality, given that male and female brains mature at different rates. Females' brains develop 1-3 years earlier than male brains, especially the areas of the frontal, parietal and temporal lobes.
The sexual brain… polymorphism?
A recent research carried out by Prof. Daphna Joeland her team suggest that human brains cannot be categorized into two classes: male brain/female brain, and conclude instead that the brains of women and men are not dimorphic but multi-morphic.
After analyzing MRI scans of more than 1,400 human brains, they found that very few brains (only 0.8%) had entirely 'female' or entirely 'male'traits. Most brains, on the other hand, are comprised of "mosaics" of features, which means that each person's brain will have a "mixture" of male and female characteristics, regardless of sex.
In short, further research is needed to deepen our knowledge in this field for it gives rise to much controversy and leads to much debate, in order to shed more light on what is truly the crux of the matter: the complexity and beauty of the human brain.
If you liked this post about sexual brain, you might find the following interesting as well:
Brain, Neuroscience
brain sexuality, brain structure, Neuroscience, Sex chromosomes, Sex hormones, sex-related differences
About Cristina Martínez de Toda
Neuropsychologist
She is a writer of neuropsychology articles for different specialized media.


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East Sussex meals on wheels subsidy could be scrapped by county council
Meals on Wheels service.C119910-2 ENGPPP00120111230152959
The subsidy for meals on wheels in East Sussex could be scrapped by the county council as it looks to make more cost savings.
Back in 2015 Apetito's contract to run meals in the community ended as the authority moved away from a single provider arrangement.
However facing the need to find £46m of savings over the next three years East Sussex County Council is considering removing the entire £483,000 subsidy that supports clients to pay for their meals from a range of different providers.
They would then have to pay the full cost of the service.
The proposals are contained in £12.3m suggested savings for the next three years, leaving the county council another £33.4m to find under a worst-case scenario.
This also comes as the council published its 'core offer', which sets out what services it should be able to provide with the level of financial resources available over the next three years.
Keith Glazier, leader of the county council, said: "We will be consulting on it. At the end of the day withdrawing support for anything is not going to be welcomed but it's a balance and a decision that we need to take and we need to be assured that people will still get the nourishment and needs individually that they have."
In her report chief executive Becky Shaw described how the core offer 'is not the ideal that we would wish to be able to provide but seeks to capture what is most appropriate and possible in a time of austerity'.
The core offer is due to discussed by the council's cabinet next Tuesday (November 13) and then public engagement would be held on the proposals.
Any budget decisions for the next financial year 2019/20 would be made in February by all councillors.
Other proposals included in the £12.3m savings programme are potential funding reductions to the library service, increased on-street parking charges where possible, a possible reduction in the number of household waste recycling sites, changing the monitoring of school performance to a 'light-touch approach', cutting back on some preventative work and reviewing both early help services and care packages for working age adults.
St Leonards project transforming run down and derelict buildings into quality affordable housing
Pirate Day in pictures
HRH The Princess Royal opens new MRI Suite
Police name man who died outside St Leonards Sainsbury's
Three arrested after armed police are called to Hastings address
Sussex County Cricket Club
More from Hastings and St. Leonards Observer


The latest weapon in the arsenal of medication against pain caused by arthritis is a new class of NSARs called COX-2 inhibitors. Compared to standard NSARs, these prescription drugs carry a lower risk of bleeding and other gastrointestinal problems.
This is good news for 30 percent of NSAR users, who are estimated to have long-term gastrointestinal problems as a consequence of taking older drugs, and for 10 percent of users who had been forced to stop using NSARs due to unpleasant side effects.
All NSAR drugs relieve pain in basically the same way - by blocking an enzyme called cyclo-oxygenase or COX. As it was mentioned, that enzyme produces prostaglandins, important chemical compounds which perform many different functions in the body. In 1991, researchers discovered that COX appears in two forms: COX-1 - which produces important prostaglandins that keeps the gastrointestinal system covered with its protective mucous membrane - and COX-2, which is responsible for the synthesis of those prostaglandins which play an important role in causing pain and inflammation in the body. Because of that, blocking COX-1 enzymes was considered bad.
A standard NSAR drug has a crude and simple approach towards COX enzymes: it relieves pain and inflammation by blocking COX-2, but it unfortunately also blocks COX-1, which makes your gastrointestinal system sensitive to irritation, which can cause ulcers and bleeding. This is where COX-2 inhibitors, NSARs developed exclusively to act only on COX-2 enzymes, come into action.
Many research studies comparing COX-2 inhibitors to standard NSARs have shown that COX-2 inhibitors are not more efficient against pain and inflammation. If you are taking a standard NSAR which is working well and alongside that is not causing any problems, switching to one of the COX-2 inhibitors does not necessarily mean an improvement for you.
Even though COX-2 inhibitors may cause less gastrointestinal problems than standard NSARs, it is not true that they come without risks. Clinical trials have shown that in people taking COX-2 inhibitors, ulcers, irritation and other problems still appear.
COX-2 inhibitors are much more expensive than standard NSARs, which can prove to be of importance since general practitioners are being increasingly encouraged to choose drugs that are most economic.
Unlike Aspirin, COX-2 inhibitors do not prevent blood clotting and in that way do not help prevent heart attacks or strokes, and may actually carry an increased risk for those people already suffering from heart conditions. Such people should not take COX-2 inhibitors.
People who should be taking COX-2 inhibitors but are allergic to sulpha drugs should avoid celecoxib, which can cause similar allergic reactions. Meloxicam does not cause such reactions.
Are COX-2 inhibitors the drug for you?
Are you suffering from a heart condition or have an increased risk of developing one? (your risk is increased in the case you are suffering from diabetes, high blood pressure or high cholesterol levels) If your answer is "YES", COX-2 inhibitors are not for you. If the answer is "NO", read on.
Are you suffering, or have suffered in the past, from an ulcer?
Have you previously had difficulties with standard NSARs?
If you have answered "yes" to one or several questions of the three above, treatment by COX-2 inhibitors may be your solution.
According to research published in July 2000 in the Annals of Internal Medicine magazine, COX-2 inhibitors celexoxib and meloxicam are no safer than standard NSARs when it comes to jeopardizing kidney function in healthy elderly people. If you are older than 65, and are regularly taking celexoxib, meloxicam or any other NSAR for arthritis, ask your physician to refer you to blood tests with which you could monitor your kidney functions.
In the UK, one to two percent of all patients taking NSARs had been admitted to a hospital due to the harmful effects of the drugs to the gastrointestinal system. It has also been estimated that between 2.500 and 3.000 cases of deaths every year can be be attibuted to taking these drugs. Despite that, the use of NSARs keeps growing so one might say that more enthusiastic consumers take risks. Research has shown that some NSAR drugs have a higher chance of causing serious problems than others.
In the US, the Food and Drug Administration has approved meloxicam as an NSAR in 2000, but it opposed its categorization into COX-2 inhibitors, being as it is claimed to be selectively inhibitive of COX-2 in therapy doses. According to the opinion of the FDA, drugs marked as COX-2 inhibitors must work exclusively on COX-2 - even in doses twice higher than their therapy doses - and meloxicam does not fall under that standard. In the UK meloxicam was approved as a COX-2 inhibitor in 1996. Comparative research has clearly shown that it causes fewer side effects than standard NSARs.


Patrick Murphy is a medical herbalist trained in electrodermal screening in Murcia, Spain. Patrick was trained by Professor Joaquin Fernandez Alcaraz and is fully accredited in carrying out this popular health screening alternative medicine method.
Patrick first became interested in electrodermal screening a number of years ago when he himself was tested by Professor Alcaraz. To Patrick's surprise, a number of health issues that came up during the testing were 100 per cent accurate when he went on and had CT scans. Due to the effectiveness of the testing he decided he wanted to learn more, and trained with Professor Alcatraz until he became completely proficient.
Electrodermal screening is a diagnostic method used in alternative medicine. By measuring the skin's electrical resistance, electrodermal screening is said to detect energy imbalances along meridians - invisible lines of energy flow in traditional Chinese medicine.
According to proponents, electrodermal screening may help to detect and treat illnesses such as allergies, organ weakness, food intolerances, nutritional deficiencies, and more.
During the screening, a person typically holds a probe in one hand, while a second probe touches another part of the body. A tiny electrical current (which cannot be detected by the person being tested ) is sent through the circuit and a reading is made on a galvanometer on a scale between 0 and 100.
Readings can be taken at different places on the skin, corresponding with acupuncture points, to determine if there is an imbalance in a person's energy which may signal illness. In addition, a potential allergenic substance may be placed in a holder on the circuit - a higher reading on the galvanometer suggests a greater sensitivity to the substance, according to proponents.
A person can also be tested for different types of treatment. Samples of various remedies (such as supplements ) may be placed in a holder as the probe is touched to the affected area.
Patrick will be holding an electrodermal health screening day at 46 The New Glebe, Tuam, Co Galway this Saturday, February 18. If you require further information phone (093 ) 27033 or (085 ) 8810692, or email [email protected].


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We began with a challenge to the status quo—a novel approach to museum interpretation replacing wall labels with a personalised, location-based interface that puts the visitor at the centre of the experience.
From here, Art Processors grew out of hard work, good and bad ideas, risk-taking, laughs (usually at our own expense) and the occasional language warnings.
We like a challenge and we are always working to find new ways to magnify people's natural inquisitiveness.
More than a decade later we are an international organisation with a diverse staff based in Melbourne, Hobart, Sydney, New York City, Washington, D.C., Atlanta, Milwaukee and San Francisco.


We've cleaned for thousands of homes in Sydney for more than 10 years. You will find us to be reliable, affordable, and flexible. We are used regularly by reputable real estate agents such as McGrath and Raywhite.
We steam clean domestic and commercial, no job is too big or too small!
Work completed to the highest standard to insure your satisfaction.


Gorgeous Raised Bungalow On A P.R.E.M.I.U.M. L.O.T. This R.A.R.E Fully Renovated 3 Beds 2 Baths Comes W/Tons Of Upgrades! Kitchen Has 3 Different Types Of Cooking: Gas,Electric & Indoor Bbq.Hardwood Floors Throughout The Main Level, Fully Finished Basement W/ A Wet Bar. Huge Yard Size W/ Beautiful Landscape, Custom Made Firepit,Custom Made Gazebo,Gas Hookup To Bbq,Custom Made Shed W/ Hydro. 4 Yr Old Roof With 50 Year Shingles.Custom Access To Attic W/ Hydro.
S/S Fridge, S/S Stove, S/S Dishwasher, S/S Wine Fridge, S/S Beer Fridge, S/S Exhaust Fan,Fridge In Basement, Indoor Bbq,All Elfs,All Window Covers, Washer & Dryer (As Is).Excluded: Freezer In Basement, Furnace And Cabinet Located In Garage.


Needed the heater on in the Jeep when we started out first thing this morning. Also made sure to wear a nylon jacket to ward off a cold wind when outside the Jeep. Under clear blue skies it didn't take long for things to warm up a tad and for me it was a perfect weather day with temps hanging out in the mid 60's. Couldn't seem to get myself into travel or photo mode so Pheebs and I were back home shortly after we left. Taking advantage of the cooler day I spent a few hours in the back yard tearing down some old Virginia Creeper vines I had planted years ago. Those vines had pretty much overgrown one of our sheds. Luckily I didn't encounter any problems with my wrist and was also able to begin the front yard clean-up now that the tree cutting is done. Bit of a mess out there………………….
At the height of a political corruption trial, the prosecuting attorney attacked a witness. "Isn't it true," he bellowed, "that you accepted five thousand dollars to compromise this case?" The witness stared out the window, as though he hadn't hear the question. "Isn't it true that you accepted five thousand dollars to compromise this case?" the lawyer repeated. The witness still did not respond. Finally, the judge leaned over and said, "Sir, please answer the question." "Oh," the startled witness said, "I thought he was talking to you."
Sometimes those days happen but once get a chance to travel a bit that will change. sure was could thing morning though for a while.
Perfect day here too. Great workin day.
You were busy doing yard work, glad your wrist is hanging in there for you. That Judge Groaner was great.
Do you want to know who invented the first snowplow that could be moved up and down from inside the vehicle???? My Dad did when he returned from WWII--on his jeep--up to that point once the plow was put on a vehicle it stayed down on the ground!! not joking--my dad invented alot of neat stuff--he just never had anything patented--even when he died at age 73 in 2000 he had a invention in his wood working shop that everyone else had to use by hand--his run off an garage door opener!! Now if he had just patented those things!!


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Final Friday Feb. 28 at Newman University Steckline Gallery features 'Subjects Removed' by Johnny Sutton
by Ken Arnold, Feb 20, 2014
The Newman University Steckline Gallery will present "Subjects Removed" by Johnny Sutton as the sixth show of its 2013-2014 season. The exhibit of photography, which begins with a Final Friday reception from 5 to 7 p.m. on Friday, Feb. 28, will be on display through March 21. Both the reception and admission to the gallery are free and open to the public.
An "Art for Lunch" presentation by Sutton will be held Tuesday, March 4 from noon to 1 p.m. in the gallery. A light lunch will be served on a first-come, first-served basis. Guests can also bring their lunch. This event is also free and reservations are not required.
Sutton studied sculpture and painting at Wichita State University from 1969 to 1972, spent six years travelling the world, and exhibited his paintings regionally through the 1970s and '80s. In 2000, he started exhibiting photography and has centered on that medium since, while still maintaining his "painter's eye."
Over the past four years, Sutton has divided his time between living in Wichita and in Bassano del Grappa, Italy – a small, picturesque town near Venice. During this time, Sutton wrote a novel: a political exposé set in southern Italy. With his book completed, Sutton returned to artwork. The Boat Series is his first exhibit of new work in five years.
The artist Steve Murillo has described Sutton's newest work, saying, "He calls upon his skills as a painter, juxtaposing, layering and augmenting with reflective watery abstractions, a tapestry of files from a sundry collection of images, to establish what at first seem like snap-shots, yet these are anything but. The compositions feel like paintings; everything within the frame is under Sutton's control."
For Sutton, boats symbolize self-reliance and an escape from society. "It's a self-contained existence. You're on your own out there, to deal with the unpredictable," Sutton has said. His exploration into the subject began with fishing boats that had been pulled out of the water, looking as if they were washed ashore, stripped of valuable parts and left to rot on the beaches of Sicily, Ireland, Greece, and Italy. Then his subject shifted to the canals, pleasure craft, workboats and water.
Through his work Sutton asks, "Are intangible reflections less valid than wood and steel? What is manifest? Sharp details suggest that the boats exist as presented. It is a misdirection. When all things visual are given equal weight, subjects can dematerialize. An artist may reassemble as he chooses. He is not obligated by what he sees in front of him."
The Steckline Gallery is located inside the De Mattias Fine Arts Center on the Newman campus, 3100 McCormick. The gallery is open Monday through Friday from 9 a.m. to 4 p.m., or by appointment. For more information, call 316-942-4291, ext. 2199.
Published February 20, 2014 By Ken Arnold
Categorized as Events, News, News Releases Tagged Art for Lunch, Final Friday, Johnny Sutton, photography, Steckline Gallery


text:
In 2010, the Campeonato Brasileiro Série D, the fourth division of the Brazilian League, will be contested for the second time in history. The competition has 40 clubs, four of which will eventually qualify to the Campeonato Brasileiro Série C to be contested in 2011.

Competition format
The 40 teams are divided in ten groups of 4, playing within them in a double round-robin format. The two best ranked in each group at the end of 6 rounds will qualify to the Second Stage, which will be played in home-and-away system. Winners advance to Third Stage along with the three losers with best record in previous stages. The Quarter-Final winners will be promoted to the Série C 2011. As there is no Série E, or Fifth Division, technically there will be no relegation. However, teams who were not promoted will have to re-qualify for Série D 2011 through their respective state leagues.

Participating teams

1 The second best team, Veranópolis withdrew.
2 Both the second best team, Democrata-GV, and the fourth best team, Villa Nova withdrew.
3 All Goiás-based teams withdrew. Since Goiás clubs were already allocated in Group 6, the entries were passed on to Distrito Federal, also on Group 6, and better placed on CBF's Ranking, ahead of Tocantins, also on Group 6.
4 All Roraima-based teams withdrew. Since Roraima clube were already allocated in Group 1, the entry passed on to Pará, better placed on CBF's Ranking.
5 The second best team Corintians de Caicó and the fourth best team Santa Cruz (RN) withdrew.
6 Briefly known as Manaos
7 Santana withdrew.
8 Murici and all the other Alagoas State Championship First Division teams withdrew due to the floodings

Results

First stage

Group 1

Group 2

Group 3

Group 4

Group 5

Group 6

Group 7

Group 8

Group 9

Group 10

Second stage
First leg played on September 4 and 05; Second leg played on September 11 and 12.

|}
Teams in the left column played second match at home.

Third stage
First leg played on September 25 and 26; Second leg played on October 2.

|}
Teams in the left column played second match at home.

Three of the five 3rd stage losers qualify due to their overall record:Qualification After 3rd Stage Matchday 02, October 2

Bracket

(p) won on penalty shootout.
(a) won by away goals rule.

Quarter-finals
First leg played on October 10; Second leg played on October 16 and 17.

|}
Teams in the left column played second match at home.

Semifinals
First leg played on October 23 and 24; Second leg played on October 27 and 30.

|}
Teams in the left column played second match at home.

Finals
All times Brazilian Daylight Saving Time

1 Since América's stadium, SESI, doesn't have the minimum attendance capacity, the game was transferred from Amazonas to Pará

Guarany de Sobral won 5–2 on aggregate.

América (AM) was judged not guilty on November 5 by the STJD, accused of fielding an out-of-contract player in the Quarterfinals against Joinville. If found guilty, the club would have been disqualified from the Série D, losing its promotion, which would then by awarded to Joinville. The Semifinals should be then replayed, this time facing Madureira and Joinville. The club will now be judged again, accused of fielding a suspended player in the Second Leg of the Semifinals against Madureira.On November 12, América (AM) was declared guilty of fielding a suspender player. However, later on the same day, the club achieved to suspend the decision.
Finally, on December 9, the STJD decided to punish América (AM) with the loss of 6 points due to fielding an out-of-contract player. América (AM), that way, loses its promoting, that being awarded to Joinville.

Final standings

Top goalscorers

References

Campeonato Brasileiro Série D seasons
4

redpajama_set_name: RedPajamaWikipedia


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text:
Q: Bounded Variation and Continuity Let $f$ be of bounded variation on $\mathbb{R}$. Let
$$
V_{f}(x)=V(f ;-\infty, x)
$$
Prove that $f$ is continuous at $c$ if and only if $V_{f}$ is continuous at $c$.
Update: $V(f ;-\infty, c)=\sup \{V(f: a, b):[a, b] \subset(-\infty, c]\}$
It seems that the proof for continuity of function $f$ at closed interval $[a,b]$ can't be applied for the interval $(-\infty, x)$, and requires other techniques to be implemented. Are there any suggestions on proving this continuity property?! Maybe, dividing into two cases of RHS & LHS limit, along with gauging the mesh of partition?!


text:
playnstream.com Watch Streaming and Download Full Movie in HD
Watch Hellboy (2019) Full Movie Streaming
Hellboy tell story about "Hellboy comes to England, where he must defeat Nimue, Merlin's consort and the Blood Queen. But their battle will bring about the end of the world, a fate he desperately tries to turn away..".
Cast : David Harbour, Milla Jovovich, Ian McShane, Sasha Lane, Stephen Graham, Daniel Dae Kim, Sophie Okonedo, Alistair Petrie, Brian Gleeson, Penelope Mitchell, Mark Stanley, Thomas Haden Church, Nadya Keranova, Maria Tepavicharova, Ana Tabakova, Terry Randal, Mario de la Rosa, Christopher Mata, Atanas Srebrev, Dawn Sherrer, Michael Heath, Rick Warden, Nitin Ganatra, Markos Rounthwaite, Ilko Iliev, Joel Harlow, Dimiter Banenkin, Vanessa Eichholz, Kristina Klebe, Charles Shannon, Carl Hampe, Tony van Silva, Josh Finan, Jonathan Steele, Simon Feek, Ava Brennan, Anthony Delaney, Jasmine Audoux-Prevot, Meglena Karalambova, Anna Bankina, Rut Rafailova, Laila Morse, Peter Oxley, Nikolay Stanoev, Troy James, Emma Tate, Manal El-Feitury, Elizabeth Mehari Kahsai, Said Barry Abdulai, Katya Peneva, Natasha Kaplinsky, Valentin Stojanov, Victor Rangelov, Vasil Tsvetkov, Joshua Samuel Hector
Runtime : 121 minutes (2' 01")
Genre : Action Adventure Fantasy Science Fiction
Production : Campbell Grobman Films Dark Horse Entertainment Millennium Films Summit Entertainment Boyana Film Studios
Release : April 10, 2019
Countries : Bulgaria
Languages : Deutsch
msbreviews
5 day ago - If you enjoy reading my Spoiler-Free reviews, please follow my blog :) Guillermo del Toro's pair of Hellboy movies were always pretty acclaimed by both critics and audience. So, if a reboot was in the works, it had to be way different from the originals or, at least, capable of separating itself from them. Neil Marshall's film is definitely distinct, but not in a good way. Sadly, this is one of the worst movies of the year, so far. David Harbour tries super hard to bring this story to safe haven, but his outstanding performance can't fight back all of the painfully long and repetitive exposition dumps, an editing worthy of a Razzie Award (if they had such a category), and cringe-worthy comedy bits. The trio of writers failed in almost everything. Even Hellboy, as a character, becomes a caricature of himself at one point. Milla Jovovich, who is not a bad actress at all, offers such an over-the-top display that only comes off as cliche, cheesy, and the complete opposite of menacing. Obviously, her extremely villainous script doesn't help. Sasha Lane (Alice) is the only one who actually portrays a likable character (excluding the protagonist) and delivers a compelling performance. Daniel Dae Kim is also good as Ben Daimio. Unfortunately, a talented cast is not enough to overcome the undeniable screenplay issues, which tells a convoluted story, filled with heavy exposition through annoying flashbacks (I lost count of how many there are). The rock'n'roll score doesn't always work, becoming uneven and making some transitions just weird. However, credit where credit is due, it does make the action sequences a lot cooler. There are some great action moments where Hellboy shines, but overall they are ruined by sloppy editing. Honestly, I don't know how Marshall can direct such beautiful one-take fights (or "stitched one-take" sequences, like one towards the end) and horribly edited ones in the same film, so many times. The visual effects disappoint as much as they impress, but Hellboy's makeup and costume are, at least, on-point. In the end, the story and the characters are the two pillars of any movie, and Hellboy fails to deliver a well-written and captivating adventure, as well as compelling characters. All in all, Hellboy is a huge misstep in Neil Marshall's filmmaking career and he's going to have to work hard to get another opportunity at a blockbuster. His film is already suffering losses at the box-office, which proves that the interest in the reboot of this franchise is not big enough to warrant a sequel. Admittedly, it has its good moments and David Harbour embodies his character seamlessly, carrying the movie for as long as he can. Nevertheless, a good cast and some occasionally cool action sequences are not enough to fight back writing issues, uneven soundtrack, cheesy comedy, heavy exposition dumps, and the worst editing I've witnessed this year, so far. It's a headache that most people might not find worthy of the price of admission... Rating: C-
8 day ago - Despite the less than stellar ratings this movie has received I have to say that I quite liked it actually. It is a much more violent, gory and adult movie than the previous Hellboy movies and this is probably contributing a lot to my appreciation of it. I so dislike when they dumb down a story or character just because the bean counters think they can get more kids to watch it and thus make more money. Or worse, because they want to cater to the easily offended whiners. This movie starts off already in the first scene where the language make it clear the easily offended should have stayed home. It continues in the same manner. It is indeed a quite violent movie with a lot of gory effects. At least for a movie based on a "regular" US comics book character. When the big demons are released towards the end of the movie and the human casualties mount the movie becomes quite inventive in the various gory ways a human can be killed. Then we have the scene with the "birth" of Hellboy which is, luckily, fairly true to the original story and shows not only Nazis but doesn't resort to any SJW dumbassery and tries to obfuscate parts of the Nazi uniforms. Instead the swastika is displayed as it should be. That should be enough to get most SJW whiners to shit themselves. Needless to say there is not much politically correct preaching in the movie either which is a relief. The story is fairly okay. Nothing really to write home about but not really bad either. The action is, obviously, quite good. Hellboy himself is played fairly well by David Harbour and Ian McShane is not bad at all as Professor Broom. Milla Jovovich never really shined as The Blood Queen though. There are a few things that where not stellar as well though. That warthog looking changeling which played a central part of the movie was often just ridiculous and the outburst by Hellboy and rant about why humans and demons could live in piece or something was completely unnecessary. Also, I felt that Hellboy was on the receiving end of the clobbering a bit too much. It was really not until the six-month-after scenes at the very end that he really displayed the self confident ass-kicking character that I would like to see him as. Anyway, I quite liked the movie and it's a shame that it didn't get better ratings. That Rotten SJW tomatoes gave it shit ratings was expected of course although even with their new censored user rating system they didn't manage to get their "audience" to get in line with their "critics". 17% critics rating while over 50% of the audience gave it a rating of six or more. Big fail again RT. The after scenes made it quite clear that they hoped for a sequel but with the poor performance I do not think that will happen. A shame if you ask me.
3 day ago - I don't really get the intense vitriol directed at the 2019 _Hellboy_. I mean it's not especially good, it's certainly worse than both del Toro movies, but the absolute dogpiling it got doesn't seem 100% warranted to me. There does seem to be a lot of mismatches in the developmental process that are very apparent in the final product though. _Final rating:★★½ - Had a lot that appealed to me, didn't quite work as a whole._
1 day ago - I may not be a big fan of Guillermo Del Toro (talented filmmaker but I don't stand at attention with his every project), yet his visual flair was on display with 2004's Hellboy, something that was sorely lacking in this reboot. Also lacking was Ron Perlman's stellar charm, something David Harbour, fine actor and all, didn't possess underneath the comic-accurate make-up and prosthetics. But beyond all that, this was an ugly movie with no creativity and, quite frankly, outright dull at times even during the action scenes. It was only two hours but felt so much longer, happy to see it flopped at the box office.
Sheldon Nylander
7 day ago - If Guillermo del Toro's version of Hellboy is the imaginative grand symphony, this version is the discordant heavy metal little brother. Based on "The Wild Hunt" and "The Storm and the Fury" storylines in the comics doesn't save it, either. Lacking the Del Toro's vision, the character and monster designs are pedantic at best. David Harbour plays the titular infernal hero and while at first the costume design seems grittier than Ron Perlman's Hellboy, it becomes clear very quickly that, while Perlman became the character and almost seemed to meld with his costume, Harbour seems to be fighting his costume. It's like watching one of the most uncomfortable and anxiety-ridden wrestling matches one can imagine. I kind of felt sorry for Harbour as he's a good actor with the right material, but he got handed such terrible material to work with. To his credit, it's clear that he does try to sell it, but when you're selling crap, it's still crap. The characters come off more as caricatures. Their relationships are so basic and one-dimensional even if they exist that we find that we don't really care. And that's the major problem. The stakes aren't built up enough to make us care. It's a good versus evil comic-book film and we don't really care whether the good guys live or if the bad guys win. Making the audience care and identify with the characters should be the bread and butter of "Hellboy." Instead, we're given a cracker and told to run along and play. Don't bother unless you are a major fan of the comics or the actors and simply HAVE to see it. Even then, you might want to consider steering clear as it could taint your love for these.
Copyright 2015 playnstream.com | All rights reserved


text:
7 questions to watch after criminal charges filed in the Theranos saga
By Rebecca Robbins and Damian Garde June 18, 2018
Jeff Chiu/AP
SAN FRANCISCO — Federal prosecutors on Friday filed criminal charges against Theranos CEO Elizabeth Holmes and the company's former president Sunny Balwani — marking a pivotal turning point in a scandal that has rocked the business world and captivated the public imagination.
So, what's next for the Silicon Valley villains of the moment? Here are seven questions to watch as the case moves forward.
1. Will the case go to trial?
Holmes and Balwani are facing serious allegations: nine counts related to defrauding investors, patients, and doctors, carrying a penalty of up to 20 years in prison and up to $2.7 million in fines. Holmes and Balwani seem likely to go to trial, though it's possible one or both of them could avoid the hoopla with a guilty plea.
The two chose different paths three months ago, when the Securities and Exchange Commission charged them with massive fraud in a civil case. Holmes immediately settled with authorities, agreeing to pay $500,000 without admitting or denying guilt. But Balwani opted to fight the charges, and he's due in court later this summer.
2. Will Holmes and/or Balwani try the my-ex-duped-me defense?
Adding intrigue to the case is the fact that Holmes, 34, and Balwani, 53, were romantically involved for years while they ran the company as a duopoly. According to Wall Street Journal reporter John Carreyrou's new book about the scandal, they got together not long after Holmes dropped out of Stanford at age 19 to start Theranos in 2003 — and broke up in the spring of 2016, when Holmes pushed Balwani out of the company as Theranos's troubles mounted.
STAT+: Exclusive analysis of biopharma, health policy, and the life sciences.
All of which points to the possibility of a tried-and-true defense: I was tricked by my lover.
Don't be surprised if Holmes's defense tries to point the finger at Balwani, and Balwani's at Holmes. Meanwhile, a statement put out on Friday from Jeffrey Coopersmith, the attorney representing Balwani, offers an early hint of what Balwani's defense might look like, painting Balwani as an honest, well-meaning hard worker whose business simply failed. It's worth noting that the statement doesn't once mention Holmes, but you can expect that to change.
3. What will happen to Theranos?
Last we heard, the blood-testing company was working on a technology called "MiniLab" that would test blood drawn the old-fashioned way — with a needle in the arm — rather than the promised finger prick that made Theranos famous. Now, in a move timed with the unsealing of the indictment, Holmes is out as CEO. Her replacement is David Taylor, the company's general counsel.
Taylor is walking into a difficult situation. The company is running out of money, and it debts are piling up. According to the Wall Street Journal, if Theranos can't turn things around, creditor Fortress Investment Group could seize the company's assets and force it to liquidate as early as this summer.
4. Will there be a reckoning for Theranos's high-profile supporters?
Among Holmes's most voluble fans were Sens. John McCain and Joe Biden, CNBC star Jim Cramer, and former Secretary of State George Shultz. To date, not one has spoken out against Theranos or recanted his prior cheerleading. But each could face questions about what he knew and when.
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McCain spoke highly of the company throughout 2015, promoting Theranos's work in Arizona and tweeting a photo of himself with Holmes on the very day the Wall Street Journal's first exposé went to print. The same year, Biden called Theranos' California facility "the laboratory of the future." Neither has mentioned the company since.
As for Cramer, he hosted Holmes on "Mad Money" the day after the first Journal story, giving her a friendly and uncritical platform to deny the allegations against Theranos. Shultz, now 97, may have the most to answer for, as the Journal's reporting revealed that after his grandson, Tyler, blew the whistle on Theranos, the former secretary of state repeatedly pressured him to keep quiet.
5. If there is a trial, who will testify?
Expect the government to try to bring forward as star witnesses some of the former Theranos employees who blew the whistle on the company, including the younger Shultz. Theranos' investors and partners, some of whom have already sued the company, could also be called to the stand to detail how Holmes and Balwani duped them into parting with their money.
The defense, meanwhile, may have a harder time. As the world came crashing down around Theranos, only one voice has persistently defended it: Tim Draper, a storied Silicon Valley investor and a partner at DFJ, has repeatedly spoken up for Holmes and accused the media of unfairly persecuting her. He could serve as a character witness for a defendant who appears to have few remaining friends.
6. What new details could be brought to light in a trial?
Each new Theranos revelation seems to layer in power, corruption, and celebrity. And a public trial could tease out yet more.
Carreyrou's new book shows that the deception at Theranos began as early as 2006, but a trial could unveil more detail about how far back the deception went. A trial could also shine more light on the lies that Holmes and Balwani told investors about the state of their business and their capabilities of their technology. And it could reveal more examples of the harm that the company's blood tests sold in Walgreens stores in California and Arizona may have inflicted on patients.
7. How much public attention could a trial command?
The 1990s brought the O.J. Simpson trial. In the 2000s, it was Ponzi schemer Bernie Madoff. Will this decade's big court trial be about blood testing?
It seems possible. Those other historic trials brought celebrity, wealth, and can't-look-away coverage — all ingredients that a criminal trial over fraud at Theranos seems poised to deliver.
About the Authors Reprints
Rebecca Robbins
Health Tech Correspondent
Rebecca covers health technology. She is the co-author of the newsletter STAT Health Tech.
@rebeccadrobbins
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Comment by Don on June 18, 2018 at 9:40 pm
Well if Biden and Hillary are contacts or "friends" the new Steve Jobs will walk. Anyone who knew anything about diagnostics knew this was a scam. The next scam is CRISPR. Interesting but no where near the hype
Comment by Jeff on June 19, 2018 at 2:03 pm
CRISPR has actually had results, the wait is on negative results
Comment by Denise on March 26, 2019 at 7:07 pm
Don no where in the store is Hillary mentioned. That would like me sticking Trump in there…no true and unnecessary.
Howard Dorfman says:
Comment by Howard Dorfman on June 18, 2018 at 4:55 pm
The Theranos story presents the classic combination of greed and hubris. What distinguishes this story from so many we have seen since Enron ( and before) is that patient safety and health were seriously compromised. While nobody can truly determine one's culpability without either full due process or entry of a plea, it is important to have all of the facts available and disincentivize such conduct in the future since greed and hubris cannot be surgically removed from the human condition.
Bobby Gladd says:
Comment by Bobby Gladd on June 18, 2018 at 3:58 pm
Good article.
One thing is certain; to the extent that Holmes speaks at all during trial, we won't be hearing that bogus baritone voice. It'll be all 17-yr old chirpy cheerleader naif, fake eyelashes blinking away.
I'm dubious at this point that she'll get heavy time if convicted. I'd like to be wrong.
Comment by Scott on June 20, 2018 at 1:51 pm
She's going to play the naive card. And, I believe she did end up way over her head in this whole scheme as a very young ceo. Still, the fake voice, the wardrobe, etc… were all well-calculated manipulations which are going to come back to bite. Since she's dem and Biden, McCain love her, and that she's the awesome female breaking glass ceilings (and then falling back through them but we won't mention that here.), if she goes to trial in Santa Clara County, there is probably not going to be one woman on the jury who would convict her. Some evil white old guy will be the real reason for the scheme.
lorin says:
Comment by lorin on June 18, 2018 at 2:16 pm
Hi, thank you for your thought provoking article. I really hold that every single "cog" in the legal system will work towards ensure decades long incarceration for the two of them.
It is clear, it was fraud from the onset and they must be made an example by way of punishment.
The only thing I worry about is that, Holmes never sold any of her holdings with Theranos and therefore ultimately did not profit from the scam.
I hope this fact does not became key in deciding her fate because she flat out knew from day one that her mission statement was nothing but deceit and fraud built upon lies, coverups and thought out corporate secrecy.
Comment by Brett on June 18, 2018 at 7:24 pm
Considering that Holmes was all set to host a fundraiser for Hillary (non-one-percenters with small houses need not apply), I'd say she profited plenty.
Like the 1 per centers who worship on the alter of Trump..
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