text:
Gene therapy for arthritis – where do we stand?
Yuti Chernajovsky1
Arthritis Research & Therapy volume 7, Article number: 227 (2005) Cite this article
The successful use of biologicals in the treatment of rheumatoid arthritis, psoriatic arthritis and spondyloarthritis has had a major impact on the management of these conditions. The challenge in the development of gene therapy as an alternative to these current treatments is to demonstrate that such therapy is more advantageous for patients from the therapeutic and safety points of view. Also, it will need to be demonstrated that gene therapy for the arthritides is economically feasible and that patient populations worldwide will be able to access these treatments.
Gene therapy for arthritis has been the subject of several recent reviews [1–5], in which the targets, vectors and methods of delivery are well documented. Interestingly, many of the titles of these reviews contain a question mark, as does the present commentary. This is because, in contrast to other areas of medical research in which gene therapy is proposed, in the arthritides biological therapy is already having great impact and some of the side effects can be prevented. This poses great challenges to gene therapists involved in this area.
Current biological therapies in arthritis and their limitations
It has been proposed that complete remission of early rheumatoid arthritis may be possible with anti-tumour necrosis factor (TNF) therapy [6, 7]. However, uncertainties persist regarding whether diagnosis is accurate at this early stage of disease; furthermore, access to facilities for early detection and availability of expensive anti-TNF treatment are still limited by lack of government funds. Differences in funding available for anti-TNF therapy in countries of the western world are dramatic (IMS Market Research, September 2004 unpublished, and G Panayi, personal communication), and in the UK only part of the population has access. With the increased use of anti-TNF therapy in other clinical conditions [8], pressure to provide access will have important economic implications. However, it is likely that, with the availability of additional biologicals, market forces may help to reduce prices.
Surprisingly, different anti-TNF drugs have different therapeutic properties [8]. This is partly due to the effector properties of their Fc portion, the different pharmacokinetics of the agents (resulting from different routes of delivery), and the immunogenicity of each particular compound, which in turn depends on each patient's immune repertoire.
State of gene therapy in arthritis
A recent search of the PubMed database revealed that during the past 14 years we have seen an increase in the number of papers published related to gene therapy and arthritis. This activity peaked in 2000–2001, with 132 publications, decreasing to 85 in the period 2003–2004. These numbers are small when compared with the numbers of publications on gene therapy in cancer or cardiovascular disease, which have been relatively stable since the year 2000 at about 2100 and 500 papers per year, respectively. This difference in publication numbers reflects both the urgent need for alternative treatments and the different ethical issues raised in the treatment of fatal diseases such as cancer and cardiovascular disease in comparison with nonfatal diseases such as arthritis.
Does this mean that research into gene therapy for arthritis is in decline? The answer is probably 'no'. Gene transfer is also an important tool with which to elucidate the pathogenesis of disease and to probe new potential molecular interventions.
The current success with biologicals, the fact that patients will not enrol in new clinical trials unless they have failed to respond to biological therapies, and the serious adverse events reported in certain trials of virus-mediated gene therapy are helping to focus the minds of gene therapists. Despite the above factors, phase I clinical trials in arthritis using both in vivo and ex vivo gene therapy approaches have been conducted [9] and some are ongoing [3].
All of the successful biological therapies mentioned above are expensive and must be administered to the individual for the rest of their life. Cessation of treatment is normally accompanied by disease relapse. Most of these biologicals are cytokine inhibitors based on immunoglobulin backbones. Thus, they exert their effects by inhibiting the actions of cytokines, and their pharmacokinetics are relatively similar.
Some questions remain to be answered. For example, will delivery of anti-inflammatory cytokines that could affect pro-inflammatory cytokine production as well as initiate repair and signalling cascades be more effective than cytokine inhibitors? Could cytokine delivery be engineered to be targeted and more effective? Can cytokine therapy accelerate the repair process, thereby shortening the duration of administration and thus reducing costs? These questions will be difficult to address using protein therapy because the half-life of cytokines is shorter than that of immunoglobulin-based molecules, and they have pleiotropic effects due to receptor expression in many tissues. Systemic delivery of cytokines has several limitations, although these can be overcome by targeting their activation to sites of disease through protein engineering to generate latent cytokines [10, 11] or by building immunocytokines [12, 13].
Gene delivery is an important tool that may help to address the limitations of cytokine therapy mentioned above and permit local cytokine delivery in a safe and effective manner, as has already been demonstrated in many studies conducted in animal models of arthritis. Local production and local consumption of cytokines can be achieved by engineering autologous cells that target the joints or by direct delivery. The proposed use of stem cells for cartilage repair will necessitate genetic engineering, at least for local immune suppression [14, 15].
Planning a safe clinical trial in arthritis
As we pointed out previously [1, 4], safety is of prime concern when treating a nonfatal chronic disease such as rheumatoid arthritis. Any delivery system should be nonimmunogenic. Hence, of the available viral vectors, both retrovirus and adeno-associated virus could be considered, as well as naked DNA. The hydrodynamic delivery of naked DNA to muscle and liver has revealed a new important paradigm to achieve nonviral, long-term gene expression [16, 17] that seems amenable to scaling up for human intervention.
The limited clinical experience to date with use of constitutive promoters that express cytokine inhibitors has not yet shown any safety issues. However, because of the relapsing and remitting phases of disease, use of transcriptionally regulated vectors to achieve cytokine expression will be extremely important [18], adding another layer of safety to gene therapy.
Local delivery could be advantageous, and the major efforts have been in this direction. Elegant studies using retrovirally transduced lymphocytes, as carriers of therapeutic genes, have been conducted in animal models [19–21]. However, this approach needs further research if we are to unravel the changes that occur in these lymphocytes and to develop the capacity to switch off gene expression or destroy the lymphocytes in case of an adverse event. The use of autologous synoviocytes expressing interleukin-1 receptor antagonist has been the main thrust of the phase I clinical trials to date [3, 9]. Whether this approach will be therapeutic and cost-effective is not yet clear.
Direct delivery of adeno-associated virus constitutively expressing a TNF receptor–immunoglobulin fusion protein to the joint is already underway, but this vector may not permit tight transcriptional regulation because it can only package a restricted amount of genetic information [22]. Whether this delivery system will be safe in the long term remains to be assessed.
It is our view that systemic hydrodynamic delivery of plasmid DNA appears to be the most feasible and efficient procedure, and should be further investigated. It will be important at first to determine whether the technology is capable of delivering similar levels of anti-TNF in the blood as are measured in the clinical trials with infliximab or etanercept, because the toxicology, immunogenicity and pharmacodynamics of the anti-TNF compounds are well established. Using transcriptional control will be of utmost importance, as explained above. If this approach is safe and successful in achieving clinical benefit in the long term, a second phase of clinical studies could be developed using combinations of anti-TNF therapy with methotrexate, or using latent cytokines and their combination with cartilage anabolic factors to facilitate rapid repair of damaged joint tissue.
The future for gene therapy in rheumatoid arthritis seems clearer and more defined, thanks to many new developments in gene transfer, gene regulation and drug design.
tumour necrosis factor.
Chernajovsky Y, Gould D, Podhajcer O: Gene therapy for autoimmune diseases: quo vadis?. Nat Rev Immunol. 2004, 4: 800-811. 10.1038/nri1459.
Chernajovsky Y, Vessillier S, Adams G, Gofur Y, Subang MC, Annenkov A, Favorov P, Daly GM, Gould DJ: Development of new molecules, vectors and cells for therapy of arthritis. Joint Bone Spine. 2003, 70: 474-476. 10.1016/S1297-319X(03)00157-X.
Evans CH: Gene therapy: what have we accomplished and where do we go from here?. J Rheumatol. 2005, 32: 17-20.
Robbins PD, Evans CH, Chernajovsky Y: Gene therapy for arthritis. Gene Ther. 2003, 10: 902-911. 10.1038/sj.gt.3302040.
van de Loo F, Smeets R, van den Berg W: Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients?. Arthritis Res Ther. 2004, 6: 183-196. 10.1186/ar1214.
Breedveld FC, Emery P, Keystone E, Patel K, Furst DE, Kalden JR, St Clair EW, Weisman M, Smolen J, Lipsky PE, et al: Infliximab in active early rheumatoid arthritis. Ann Rheum Dis. 2004, 63: 149-155. 10.1136/ard.2003.013961.
Emery P, Seto Y: Role of biologics in early arthritis. Clin Exp Rheumatol. 2003, 21: S191-S194.
Mpofu S, Fatima F, Moots RJ: Anti-TNF-alpha therapies: they are all the same (aren't they?). Rheumatology (Oxford). 2005, 44: 271-273. 10.1093/rheumatology/keh483.
Evans CH, Robbins PD, Ghivizzani SC, Wasko MC, Tomaino MM, Kang R, Muzzonigro TA, Vogt M, Elder EM, Whiteside TL, et al: Gene transfer to human joints: progress toward a gene therapy of arthritis. Proc Natl Acad Sci USA. 2005, 102: 8698-8703. 10.1073/pnas.0502854102.
Vessillier S, Adams G, Chernajovsky Y: Latent cytokines: development of novel cleavage sites and kinetic analysis of their differential sensitivity to MMP-1 and MMP-3. Protein Eng Des Sel. 2004, 17: 829-835. 10.1093/protein/gzh097.
Adams G, Vessillier S, Dreja H, Chernajovsky Y: Targeting cytokines to inflammation sites. Nat Biotechnol. 2003, 21: 1314-1320. 10.1038/nbt888.
Lode HN, Xiang R, Becker JC, Gillies SD, Reisfeld RA: Immunocytokines: a promising approach to cancer immunotherapy. Pharmacol Ther. 1998, 80: 277-292. 10.1016/S0163-7258(98)00033-3.
Nissim A, Gofur Y, Vessillier S, Adams G, Chernajovsky Y: Methods for targeting biologicals to disease sites. Trends Mol Med. 2004, 10: 269-274. 10.1016/j.molmed.2004.04.003.
Jorgensen C, Noel D, Apparailly F, Sany J: Stem cells for repair of cartilage and bone: the next challenge in osteoarthritis and rheumatoid arthritis. Ann Rheum Dis. 2001, 60: 305-309. 10.1136/ard.60.4.305.
van der Kraan P, van de Loo F, van den Berg W: Role of gene therapy in tissue engineering procedures in rheumatology: the use of animal models. Biomaterials. 2004, 25: 1497-1504. 10.1016/S0142-9612(03)00493-9.
Lewis DL, Wolff JA: Delivery of siRNA and siRNA expression constructs to adult mammals by hydrodynamic intravascular injection. Methods Enzymol. 2005, 392: 336-350. 10.1016/S0076-6879(04)92020-4.
Wells DJ: Opening the floodgates: clinically applicable hydrodynamic delivery of plasmid DNA to skeletal muscle. Mol Ther. 2004, 10: 207-208. 10.1016/j.ymthe.2004.07.010.
Gould DJ, Favorov P: Vectors for the treatment of autoimmune disease. Gene Ther. 2003, 10: 912-927. 10.1038/sj.gt.3302018.
Chernajovsky Y, Adams G, Podhajcer OL, Mueller GM, Robbins PD, Feldmann M: Inhibition of transfer of collagen-induced arthritis into SCID mice by ex vivo infection of spleen cells with retroviruses expressing soluble tumor necrosis factor receptor. Gene Ther. 1995, 2: 731-735.
Annenkov A, Chernajovsky Y: Engineering mouse T lymphocytes specific to type II collagen by transduction with a chimeric receptor consisting of a single chain Fv and TCR zeta. Gene Ther. 2000, 7: 714-722. 10.1038/sj.gt.3301149.
Nakajima A, Seroogy CM, Sandora MR, Tarner IH, Costa GL, Taylor-Edwards C, Bachmann MH, Contag CH, Fathman CG: Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis. J Clin Invest. 2001, 107: 1293-1301.
Apparailly F, Millet V, Noel D, Jacquet C, Sany J, Jorgensen C: Tetracycline-inducible interleukin-10 gene transfer mediated by an adeno-associated virus: application to experimental arthritis. Hum Gene Ther. 2002, 13: 1179-1188. 10.1089/104303402320138961.
The author acknowledges the financial support of the Arthritis Research Campaign, UK, the Wellcome Trust, Kinetique Biomedical Research Fund, the European Commission (FP5 and FP6), and continuing collaboration with and support from Dr David Gould and Mrs Gill Adams. I wish to thank Drs George Kitas and Nick Rapson for fruitful discussions, Dr Lorna Layward for reviewing the manuscript, and Nathan Fox for secretarial assistance.
Bone and Joint Research Unit, William Harvey Research Institute, Barts and The London, Queen Mary's School of Medicine and Dentistry, University of London, London, UK
Yuti Chernajovsky
Correspondence to Yuti Chernajovsky.
The author is founder of Stealthyx Therapeutics Ltd, which develops latent cytokines and other peptide-based therapeutics.
Chernajovsky, Y. Gene therapy for arthritis – where do we stand?. Arthritis Res Ther 7, 227 (2005). https://doi.org/10.1186/ar1823


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Home > CRG Homecare > Homecare Client Services > Older People > What is Homecare for Older People?
As you get older you may find everyday tasks become more challenging. It is natural to feel hesitant about seeking support, especially when you are comfortable living in your familiar surroundings. This is why homecare is the ideal solution for many older people. It enables you to maintain your independence and quality of life, providing valuable help where necessary so that you can continue to lead your life the way you want to.
The nature of homecare is very flexible depending on the individual. Our care workers can offer support with a number of different everyday tasks and activities. Round-the-clock care is available, specifically at night if you need it.
Homecare can provide the necessary support and peace of mind to allow you to continue living your life comfortably at home. Find out more about our tailored care plans and the responsibilities of your care worker.


"Child Crashes: An Unequal Burden" is the second in a series of "crash map" reports derived from CrashStat.org, an interactive online map of motorist crashes with pedestrians and bicyclists.
Children make up a disproportionate number of crash victims relative to their population in lower-income neighborhoods.
The report includes a map of the top ten intersections for crashes involving child pedestrians and bicyclists, nine of which are located either in East Harlem (Community Board 11) or the Lower East Side (Community Board 3) in close proximity to public housing developments.
Download Child Crashes: An Unequal Burden.


Nowadays, players from all over the world have hundreds of options to choose from when it comes to playing with all sorts of exciting gambling table games, sportsbook, and even video slot machines. You can visit cellular casinos like the multitude of judi casino online which you could play on your cellular phone to PC-exclusive websites that nevertheless bring about quite a lot of interactivity into your experience.
Playing for real cash online has existed since forever, though it didn't actually begin picking up steam until the Web itself started growing exponentially over a decade or perhaps almost two years ago. Just like the way Amazon started off selling books only and not earning a profit for a long time before it ended up earning its founder into the richest single man on the planet, so also did online casinos start small and with humble payouts.
Among the ways those new-age casinos online get their clients is by enabling players to try their Flash-powered cellular games like online slots or even sportsbook free of charge to give them a taste. Then soon after, when the player learns the ropes and finds out how much potential money he will win, then he will go play for real money and start really risking his hard-earned paycheck to get a lesson in the randomness of existence.
One of the other ways these casinos lure newbie players to try them out is by offering a healthy welcome bonus. Just signup and you will find a bonus. Of course, that bonus includes various caveats so that you won't end up pulling a fast one on the match. You can either just use the incentive to increase your wagers or else you have to play the bonus many times in several games until you can cash it out with your normal winnings.


Have you ever wanted to know how to make a career transition? Or how recruiters help in your job search? And what the time-frame is for the recruiting process? Well, that's exactly what we're going to help you with on this week's show, where you'll learn more about the recruiting process and how working with a recruiter works.
Have you ever wanted to know how long your resume should be? Or whether you should include a cover letter when submitting a job application? And what other resources are out there that can help you find a job? Well, that's exactly what we're going to help you with on this week's show, where you'll learn more about the tools you need to be successful in your job search.
Have you ever struggled with knowing when or how to start your job search? And how exactly recruiting and staffing agencies work to help you land that dream job? Well, that's exactly what we're going to help you with on this week's show, where you'll learn what steps you need to take to succeed in your job hunt and the part that recruiting agencies play in the process.


Looking for a Trixie - Rattle? June and Julian babyshop.
Even the tiniest fingers can grasp this cute, little rattle. Together with the crinkle paper inside, your baby will have hours of fun playing around with this new little friend!


text:
Capitaine Sinbad (titre original : Captain Sinbad) est un film américano-allemand réalisé par Byron Haskin, sorti en 1963.

Synopsis

De retour au pays, Sinbad découvre que le trône royal est convoité par le terrible El Kerim. Il décide alors de l'affronter...

Fiche technique
 Titre original : Captain Sinbad
 Réalisation : Byron Haskin
 Scénario : Ian McLellan Hunter et Guy Endore
 Directeur de la photographie : Günter Senftleben et Eugen Schüfftan (non crédité)
 Montage : Robert Swink
 Musique : Michel Michelet
 Costumes : Ingrid Winter
 Production : Frank King et Herman King
 Genre : Film d'aventure
 Pays d'origine : ,
 Durée : 85 minutes ()
 Dates de sortie :
 Allemagne de l'Ouest :
 États-Unis :
 France :

Distribution
 Guy Williams (VF : Bernard Noël) : Capitaine Sinbad
 Heidi Brühl (VF : Jeanine Freson) : Princesse Jana
 Pedro Armendariz (VF : Georges Aminel) : El Kerim
 Abraham Sofaer (VF : Fred Pasquali) : Galgo (prononcé "Galco" en VF)
 Bernie Hamilton : Quinius
 Helmuth Schneider : Bendar (Pendar en VF)
 Margaret Jahnen : la servante
 Rolf Wanka (VF : Raymond Rognoni) : le roi
 Walter Barnes (VF : Claude Bertrand) : Rolf
 James Dobson : Iffritch
 Maurice Marsac (VF : Serge Lhorca) : Ahmed
 Henry Brandon (VF : Serge Nadaud) : le colonel Kabar
 John Crawford : Aram
 Geoffrey Toone (VF : Roger Rudel) : Mohar
 Lawrence Montaigne : Jafar

Notes et références

Liens externes

Film américain sorti en 1963
Film allemand sorti en 1963
Film d'aventure américain
Film d'aventure allemand
Film avec une musique composée par Michel Michelet
Adaptation de Sinbad le marin au cinéma

redpajama_set_name: RedPajamaWikipedia


text:
Iwata: Wii U being first next-gen release "not important"
By Patrick Garratt, Friday, 20 July 2012 12:23 GMT
Nintendo boss Satoru Iwata has told Gamasutra that the timing of Wii U's release compared to new consoles from Microsoft and Sony makes no difference to the firm.
"Being first in the next generation race is not important at all," he said.
"One of the reasons we believe this is the time for Nintendo to launch the Wii U is it's going to be important for the world."
What will matter, the exec added, will be price.
"The pricing of Wii U is going to be one of the most important elements when it is going to be launched," he said.
"The environment is different. Wii U is going to be launching in a different environment than when the Wii was launched. Also, the involvement surrounding [mobile and social] businesses is different than several years ago."
Iwata also shrugged off recent analyst assertions that Wii U is dead in the water.
"Even when we were going to launch the Wii system, there were a lot of voice saying 'Nintendo should stop making hardware'," he added. "The reasoning behind that was Nintendo would not have any chance against Microsoft and Sony. The fact of the matter was: I did not think Nintendo should compete against these companies with the same message and same entertainment options for people.
"We have not changed our strategy. In other words, we just do not care what kind of 'more beef' console Microsoft and Sony might produce in 2013. Our focus is on how we can make our new console different than [others]."
Wii U releases globally later this year.

redpajama_set_name: RedPajamaCommonCrawl


Linda Sutera played Violet Weston in Theatrikos Theatre Company's production of August: Osage County from July 29 through August 14, 2016, at the Doris Harper White Playhouse in Flagstaff. The cast featured thirteen local actors directed by Nancy Wonders.
The script chronicles the saga of the Westons, a dysfunctional family living in Oklahoma, who spend most of the play recovering from and dealing with the suicide of their patriarch, Beverly Weston, and the various levels of fallout incurred and secrets revealed during the course of this "comedic tragedy." As the matriarch, Violet Weston, Linda Sutera fully inhabited a character, who is, at turns, funny, mean, biting, competitive, wry, and clever. Despite a serious and enervating addiction to prescription drugs, she also repeatedly proves herself the smartest person in the play, consistently one step ahead of her seemingly more alert siblings and children.


text:
<?php

namespace Sylius\Bundle\ResourceBundle\Form\EventSubscriber;

use Ramsey\Uuid\Uuid;
use Sylius\Component\Resource\Exception\UnexpectedTypeException;
use Sylius\Component\Resource\Model\CodeAwareInterface;
use Symfony\Component\EventDispatcher\EventSubscriberInterface;
use Symfony\Component\Form\FormEvent;
use Symfony\Component\Form\FormEvents;

/**
 * @author Anna Walasek <anna.walasek@lakion.com>
 */
class AddCodeFormSubscriber implements EventSubscriberInterface
{
    /**
     * @var string
     */
    private $type;

    /**
     * @var string
     */
    private $label;

    /**
     * @param string $type
     * @param string $label
     */
    public function __construct($type = 'text', $label = 'sylius.ui.code')
    {
        $this->type = $type;
        $this->label = $label;
    }

    /**
     * {@inheritdoc}
     */
    public static function getSubscribedEvents()
    {
        return [
            FormEvents::PRE_SET_DATA => 'preSetData',
        ];
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     */
    public function preSetData(FormEvent $event)
    {
        $resource = $event->getData();
        $disabled = false;

        if ($resource instanceof CodeAwareInterface) {
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        $form->add('code', $this->type, [
            'label' => $this->label,
            'disabled' => $disabled,
            'empty_data' => Uuid::uuid4()->toString(),
        ]);
    }
}

redpajama_set_name: RedPajamaGithub


text:
Which Jonas Brother Is The Most Well Endowed?
Andy Cohen put Nick Jonas on the spot
Joe Jonas was on Watch What Happens Live! with Andy Cohen in July, and like all of Andy's guests, was subjected to cheeky games.
Brother Nick was on recently and played "Plead the Fifth"—but refused to answer "which Jo bro is the most well-endowed?"
So when it came time for Joe to play the same game, Cohen asked him the question—but unlike his brother, Joe answered.
"This is Nick's words not mine, but he said he was going to say me. So I'm going to say me," Jonas answered nonchalantly.
That wasn't the only dirt Cohen was able to get out of the DNCE frontman. He also played "Marry, Shag, Kill" with Jonas' exes, Taylor Swift, Gigi Hadid and Demi Lovato. Which did he pick to marry and who would he have killed?
Find out in the video below:
Labels: actor, boy band, singer, teen idol
Where To Find You Favorite LGBT Stars On TV
The out comedian struggles with returning home, the loss of her mother and her own battle with cancer in this intriguing Amazon series.
One Mississippi is streaming now on Amazon
Labels: Amazon, comedian, comedy, internet, lesbian, television, Where To Find You Favorite LGBT Stars On TV
Trump Plagiarized President Obama's Inauguration Cake
Leaves a bad taste in your mouth, no?
The Trump administration has already been accused of plagiarizing: Trump's inaugural address seemed to lift passages from The Dark Knight Rises and Avatar, while his Twitter background picture was actually from President Obama's 2008 inauguration.
And, of course, Melania's convention speech was uncannily similar to former First Lady Michelle Obama's address.
But now it looks like the Trumps even cribbed President Obama's inauguration cake.
Pastry chef Duff Goldman of Ace of Cakes fame tweeted a photo of the towering confection he created for Barack Obama's second inauguration in 2013, next to the one served last night at Trump's "Salute Our Armed Services" ball.
The cake on the left is the one I made for President Obama's inauguration 4 years ago. The one on the right is Trumps. I didn't make it. 🤔 pic.twitter.com/qJXpCfPhii
— Duff Goldman (@Duff_Goldman) January 21, 2017
The two are nearly identical.
"I didn't make it," Goldman posted about Trump's cake.
This morning, Tiffany MacIsaac, owner of Washington's Buttercream Bakeshop, confirmed she made the new cake and explained the client came in with a photo of Obama's cake and asked them to recreate it exactly.
"They came to us a couple of weeks ago, which is pretty last minute, and said 'We have a photo that we would like to replicate,'" MacIsaac told The Washington Post.
MacIsaac said her team tried to steer the client toward using Goldman's cake as more of an "inspiration" than a carbon copy. "They said, 'Nope, they want this exact cake. It's perfect.' And we said, 'great.'"
She revealed that proceeds from the Trump inaugural cake are being donated to HRC, the country's leading LGBT advocacy group.
Update: Baker = @tiffmacisaac of @BttrcrmBakeshop . Was asked to recreate @Duff_Goldman cake & donated $ to @HRC https://t.co/sF5M4BdpcN https://t.co/xzZPfMesFg
— Post Food (@WaPoFood) January 21, 2017
"I'm a small-business owner and one of the things I'm very, very proud about is that I don't discriminate," MacIsaac said. "I would never turn someone away based on their age, their sex, their sexual orientation, their political views. It's just not the way we operate."
The icing on the cake in this pastry story: The Trump cake was never really intended to be eaten—everything but a three-inch slice at the bottom is inedible.
Labels: #FoodPorn, dessert, food, Inauguration, political
Report: Trump closes down White House Office of AIDS Policy
Websites are one thing, but if a source speaking to reporter Kenneth Walsh is to be believed, Donald Trump has already taken action to shutter the White House Office of National AIDS Policy (ONAP).
As Walsh reports on his blog, Kenneth in the 212:
"…a source in the HIV/AIDS research community tells me Trump has already closed the Office of National AIDS Policy, whose page has also been disabled. Revisionist LGBT activists should note the office was formed in 1993 — during the Clinton administration at the height of the plague — to coordinate government efforts to reduce the number of HIV infections in the United States."
Indeed, if you try to access the web address associated with ONAP, this page comes up:
Many have noted that the website issues might be chalked up to expected transition messiness, but that doesn't explain why some pages have remained intact or are brand new, while others are gone completely.
The director of ONAP under President Obama, Amy Lansky, tweeted a series of final farewells from her whole staff on Jan. 4:
On behalf of 8 years of ONAP, thank you to everyone who supported us. Our accomplishments are because of you.https://t.co/ClQyf6HAuu
— Amy Lansky (NARA) (@Amy44) January 4, 2017
Today is ONAP staff's last day in the office. As such, this twitter account will end. Please continue to follow @AIDSgov for updates.
It's been the greatest honor to work with my remarkable colleagues for @POTUS and the American people. Thank you for your work. Onward!
When reached for comment, Lansky told Walsh, "I have no information on what the Trump administration may or may not do with regards to ONAP."
Like countless other pressing issues associated with Trump's ascent to power, we'll have to wait to find out ONAP's fate for certain.
But it's not exactly looking good.
Labels: FYI, gay rights, HIV/AIDs, Homophobia, political
The White House's LGBT rights page has been deleted already
Well this is uncomfortable.
Donald Trump was president for roughly a few hours, and we were already seeing the first sign of danger ahead.
It's understandable that the new administration would revise the official White House web pages to reflect the positions of the incoming Commander in Chief, but some key pages have disappeared entirely.
Among them, the page dedicated to LGBT rights.
When the Obama administration created the page, it was used to showcase legislative/judicial achievements and policy updates affecting gay and transgender Americans. It also featured campaigns to combat suicide among young queer people, like "It Gets Better."
Well, not any more.
Anyone trying to find the official LGBT White House page is now met with this lovely screen:
In fact, all mentions of the term "LGBT" have been scrubbed from the site entirely:
It doesn't quite foster the same sense of inclusion as the old site, we must admit.
It's possible the Trump team will replace the page with their own LGBT section in due time — after all, Trump has been lauded as the most "pro-gay" Republican nominee ever for president by groups like the Log Cabin Republicans.
But looking beyond Trump, whose positions, like his hair, seem to change with the breeze, it's tough to find any encouragement that LGBTQ Americans will be high on the administration's priorities list.
In related and equally worrying news, all mentions of climate change have also been removed from the site.
Welcome to our new reality, where we'll have to fight even harder for justice and truth to prevail.
Labels: gay rights, Homophobia, political
Sport Saturday
From: Speed o Rex
Trevor Signorino
The center of the sporting universe today. The Australian Open of Tennis continues this weekend, with contests in the Round of 32, in Men's and Women's singles and doubles, along with mixed doubles. The event is taking place at Melbourne Park, Melbourne. At this point, Round 3 is coming to an end, as those who are moving into Round 4 are determined. Brit Dan Evans joined Andy Murray in the last 16 of the Australian Open with a brilliant performance to give Britain two men in the fourth round. Roger Federer will also advance, but phenom Novak Djokovic has washed out and will not continue in the tournament. Play continues through Thursday's celebration of Australia Day and beyond, with the finals on January 29th.
The Santos Tour Down Under also continues this weekend. Australian Richie Porte, Richie (BMC Racing Team) currently holds the Overall and King of the Mountain Jersey, with fellow countryman Caleb Ewan (ORICA - SCOTT)leading in points. Ruben Guerreiro of Portugal (Trek - Segafredo) currently holds the Young Rider jersey, with UniSA-Australia currently ahead in the team competition. Exciting stages are foreseen today and tomorrow, closing day of the Tour Down Under.
As mentioned previously, Chapecoense will play their first match today since the tragic crash which took the lives of almost all their team, a friendly against defending Brazilian league champions Palmeiras. The people of Chapeco will, once-again, fill the small Arena Conda to see some of the 22 new players who make up the squad. Three of the six survivors were players, including central defender Neto, who was one of the team's leaders. He was the last to be pulled out from the wreckage. Chapeco is a quiet, unassuming city with a population of about 209,553, a tight-knit community, and a major part of that is the Chapecoense football team. The best to them.
Another weekend of top Premier League action is upon us, and it's a big one for Pep Guardiola as his Manchester City side take on Tottenham. City have struggled in recent months, while Tottenham are on the rise, but who will come out on top at the Etihad? Meanwhile, Chelsea have Diego Costa back in the squad but don't seem to need him that much as they take on lowly Hull City seven points clear at the top of the table. Liverpool host Swansea, while Manchester United travel to Stoke and Arsenal will hope to keep up the pressure on their title rivals with a win over Burnley.
In Africa Cup of Nations play today, Ghana faces Mali, and Uganda faces Egypt as group play continues.
Today, La Liga clubs Real Madrid and Malaga faces each other. Real Madrid was flying high, having just achieved a league record last weekend with 40 straight victories as they beat Seville, but then they lost twice this week. How the mighty have fallen! Malaga has been taunting Real Madrid in social media, reminding them that last year the teams played to a draw.
Labels: athlete, Cycling, soccer, sport, Sport Saturday, tennis
Spicer Screams At Press For "False Reporting" About Largest Inauguration Crowd Ever, Period
From: Joe My God
Talking Points Memo reports:
White House press secretary Sean Spicer on Saturday accused the media of misrepresenting the crowd at Donald Trump's inauguration in order to dampen enthusiasm for the event. "This was the largest audience ever to witness an inauguration, period," Spicer said with emphasis. "Both in person and around the globe."
He accused the media of "deliberately false reporting" both with regard to photos of the crowd that were published as well as crowd estimates. "No one had numbers. Because the National Park Service, which controls the National Mall, does not put any out," Spicer said.
"These attempts to lessen the enthusiasm of the inauguration are shameful and wrong," he added. Spicer took no questions after delivering his remarks. Aerial photos of the crowd at Trump's inauguration showed much open space on the National Mall when compared side-by-side with an aerial photo of Barack Obama's 2009 inauguration.
FULL: @seanspicer: "We're going to hold the press accountable." pic.twitter.com/nK51t16Kpf
— Fox News (@FoxNews) January 21, 2017
Labels: Inauguration, political
Queerest Cities in America, 2017
From: Advocate
Only a hour's drive from Los Angeles, Anaheim is not such a small world when it comes to LGBT inclusion. The community boasts an LGBT center and a score of 80 on the Human Rights Campaign's Municipal Equality Index. It's also home to the Happiest Place on Earth, which hosts the ever-popular Gay Days celebrations. Anaheim recently open is architecturally significant ARTIC Rail Station (see above), which makes travel to L.A. and other parts of California quite a breeze. Wary of Orange County? For the first time since the Great Depression, the longtime Republican county went blue, voting for Hillary Clinton over you-know-who.
Labels: Anaheim, California, FYI, Queerest Cities in America
30 Kinky Terms Every Gay Man Needs to Know
From: The Advocate
Limits are important, and every submissive guy's limits are different. A limit is the point beyond which you do not allow Dominants to go. "Soft limits" are things that you're mostly against, but in certain circumstances may try. For instance, drinking urine is a soft limit for this writer — an act not done in most circumstances, but perhaps for special occasions (like this year's Folsom Street Fair). Soft limits may change over time. A "hard limit," by contrast, is nonnegotiable. This writer's hard limits are the presence of blood and/or feces. If either one of these appear during a scene, I'm finished, and playtime stops.
Labels: 30 Kinky Terms Every Gay Man Needs to Know, Asian-American, chubby, fetish, FYI, kinky
Prides Of The Past Live On In This Stunning Collection Of Vintage Photos
lgbt_history
"I AM ALL OF US," Harvey Milk memorial pinback, c. 1979. #lgbthistory#lgbtherstory #lgbttheirstory #lgbtpride#queerhistorymatters #haveprideinhistory#night
Labels: activist, Gay Pride, LGBT History, politician, Prides Of The Past Live On In This Stunning Collection Of Vintage Photos
Minutes Into The Trump Presidency, White House LGBT Page Taken Down
LGBT-related info from the Department of Labor has also been removed
It might be some time before we see the effects of Donald Trump's presidency on civil liberties, but there are already signs they won't be positive: The White House's LGBT page, WhiteHouse.gov/LGBT, has been taken down.
The URL now redirects to a splash page inviting visitors to sign up for updates from President Trump.
Also removed from the "issues" section of WhiteHouse.gov are pages focusing on climate change, health care and civil rights.
The page on climate change was replaced with a page entitled "An America First Energy Plan" that ignores climate change entirely and declares President Trump "is committed to eliminating harmful and unnecessary policies such as the Climate Action Plan."
The civil rights section now carries information on "Standing Up For Our Law Enforcement Community," calling for increased police.(The words "black" and "African-American" no longer appear on any policy page on WhiteHouse.gov.) As Daily Beast reports, "[It] paints predominantly black inner cities as shooting galleries."
"In our nation's capital, killings have risen by 50 percent," despite the fact that homicides in Washington, D.C. were down last year.
Activist Jay Franzone also reports the Dept. of Labor's report, Advancing LGBT Workplace Rights, has also been removed.
It's only been 25 min and the Dept. of Labor's report on Advancing LGBT Workplace Rights has been taken down. https://t.co/KzBp8VZweD pic.twitter.com/UhnWqWZvPC
— Jay Franzone (@JayFranzone) January 20, 2017
Some information is still on government sites, thankfully, including details for LGBT travelers on the State Department website, and a resources page for trans and gender-nonconforming students on the Department of Ed site.
We'll see how long that lasts.
HGTV's 11 Hottest Home Renovation Hunks
Yard Crashers
This landscape architect is easy on the eyes and can handle a chainsaw. Flowers and koi ponds spring up wherever he goes.
We'd love know what he would do to our back yard.
Labels: 11 Hottest Home Renovation Hunks, HGTV, television personality
ANOTHER LEAKED SNAPCHAT VIDEO, THIS TIME IT'S TOM DALEY'S
From: Wicked
What is it with nude leaks this week? First Cody Christian, then Tyler Posey and then Olympic diver Chris Mears. And now, Mears' fellow Olympian Tom Daley has a leak on his hands.
Although, it should be noted that Daley's isn't quite as bad; just a picture and a video where he's just showing off his chiseled body and impressive package, sadly covered by underwear. Still, that's not to take away from the beauty of it all.
You can watch the video below.
Tom Daley Leaked Video - First Part has surfaced and here it is! #tomdaley #leaked #celebritybusted #TDObsessed pic.twitter.com/S1DUsh4EN3
— Totally Gay (@sototallygay) January 21, 2017
Labels: athlete, boxer briefs, British, bulge, diver, sex tape, underwear
A Kordell Stewart SEX TAPE?? Alleged Ex-Boyfriend Puts Kordell On Blast!
From: Funky Dineva
All right y'all, let me go ahead and get this out of the way. I don't make the news, I just report…
I was minding my business as I always do when I received an email titles "Kordell". Chile, I thought it was my homeboy Kordell inviting me to a Christmas party. When I opened up the email, it's contents were disturbing. The person who drafted the email claims that they are an ex boyfriend of Kordell Stewart and they had some tea to spill.
Check it out:
"I've been dating Kordell for the last two years and yes I'm a guy.
I know the first thing is why would I hit up a blogger about it well I feel like I need to say my piece.
I love Kordell and his son Syre but I can only be manipulated so much.
When we met he was my "bro". We played golf, went on trips, he supported me when I was finishing my Masters (yes he paid) and I supported him when he was finishing up his degree earlier this year. But I feel like just because he has more money over me he can control me.
I have to give it to him, he started this well. We became friends, then close friends, slept in the bed together on trips without doing anything. Then one day… I woke up and while laying in bed he brought up last sexual encounters. He told me about how he let two girls suck his dick and one started licking his ass. He asked had I ever done or would I… I said maybe. He jokingly said "with me"? I said maybe… nothing happened for months until we got drunk and he aggressively said he wanted. Needless to say that began our relationship.
It was good for a while until his ex wife came back around. I didn't really care because he always talked about Porsha. Once he started knocking her off he never brought her up. He was giving her money every week, and would get mad when i said she's using you.
This is only the half of it."
Attached to the email was the following photo:
Now any blogger will tell you that we get emails like this with insufficient evidence ALL THE TIME…
So I wrote back:
Anyone off the street can make up the story you just provided me. I need a little more than that. text messages, pictures, something private.
What else you got?
Lord why'd I do that. Here is where things got interesting. The person on the other end of the computer then emailed me a pretty incriminating video.
No before we go any further, let me take care of some general housekeeping. I have watched the video and I cannot confirm or deny if it is actually Kordell Stewart. What I can say is that the man in the video looks a hell of lot like Kordell (I ain't trying to get sued). Take a look for yourself and draw your own conclusions.
http://funkydinevaross.tumblr.com/post/154807041320/a-kordell-stewart-naked-video-alleged-ex
So let's take a moment to be balanced and fair here. Let's just assume that the person in the video is in fact Kordell Stewart, then just who is he talking to? I found it a little suspect that the audio from the video had been removed. For all we know, the alleged Kordell Stewart in the video could have been video chatting with a woman. The person who emailed me could be some jilted female lover. Rumors on reality shows have a tendency to grow legs and run. Y'all have got to be careful about what you say about people down to the tv.
Just when I was trying to take up for the man in the video that I realized, he was showing his ass… Uhhhmmmm….. I mean….
Gary With The Tea, ask Porsha to confirm if that's her ex-husbands dinga-ling, and if he has a birth mark near his booty cheek.
Labels: African American, ass, athlete, balls, butt, cock, football, nuts, penis, sex tape
A BEL AMI SCENE NAMED AFTER MADGE'S BEST TOUR BUT SOMEHOW STILL HOT
We can all agree that the apex of Madonna's career was the Blonde Ambition tour, right? I think I just gayed up this gay porn blog a little too much for most of you. Blonde Ambition is Bel Ami's latest tribute to the male form and the hot things it can do. Lars Norgaard and Jim Kerouac (another homage!) are blonde and busting each other like crazy. As the literature says, these two are "hung, handsome and horny" and "made for each other like hand and glove." Couldn't have drooled it better myself!
Labels: anal, ass, balls, bareback, Bel Ami, blond, blowjob, butt, cock, cum, facial, naked, nude, nuts, oral, penis, porn star
How Can I Please You Sir ?
From: Brent's Auto Wall
Labels: artistic, balls, cock, erotic, hairy, naked, nude, nuts, penis, Wallpaper
39 Sweltering Pics from the Ultimate Vegas Gay Pool Party
Labels: 39 Sweltering Pics from the Ultimate Vegas Gay Pool Party, beard, briefs, bulge, hairy, Las Vegas, swimwear, Temptation Sundays
36 Olympians Who Definitely Look Better Than You in Speedos and Spandex
From: Esquire
Storm Uru
At the London 2012 Olympics.
Labels: 36 Olympians Who Definitely Look Better Than You in Speedos and Spandex, athlete, bulge, hairy, Kiwi, New Zealander, rower, spandex
48 GUYS YOU MIGHT POSSIBLY WANT TO FUCK
Minbari
Madrid, Community of Madrid, Spain
Procrastinanding...
Y tal.
Labels: 48 GUYS YOU MIGHT POSSIBLY WANT TO FUCK, beard, hairy, Spanish
Groovy Flashback: TIME Covers 1923 - 1959
From: Deep Dish
Olivia de Havilland (The Snake Pit) - December 20, 1948
Labels: actress, British, drawing, Groovy Flashback: TIME Covers, illustration, TIME, vintage
PrEP use on the rise
As awareness of pre-exposure prophylaxis increases, so does its use: More and more countries are approving its use—a new major PrEP trail is launching in the UK, where the NHS has previously dragged its feet, and Norway has started offering the therapy for free.
Additionally, clinical trials have just started in the U.S. for a new, injectable version that only needs to be administered every eight weeks.
Labels: 27 Things To Look Forward To In 2017, FYI, PrEP
25 GORGEOUS MEN PROVE: THE BEARD TREND IS HERE TO STAY
From: Cheap Undies
Labels: 25 GORGEOUS MEN PROVE: THE BEARD TREND IS HERE TO STAY, beard, Brazilian, hairy, Latino, model, shirtless
Cher! 23 Times The Dark Lady Wasn't At A Loss For Words
"I know I'm not supposed to have any opinions about politics, because I'm famous."
Labels: 23 Times The Dark Lady Wasn't At A Loss For Words, political
The 23 Hottest Guys On "Game Of Thrones," Ranked
Nothing in Game Of Thrones could ever be referred to as "adorable," but Pod (Daniel Portman) comes closest. Tyrion thanks him for his loyal squire service by hiring three prostitutes to claim his virginity, but they're apparently so impressed with his superior lovemaking ability, they refuse payment.
This we gotta see for ourselves.
Labels: 23 Hottest Guys On "Game Of Thrones", actor, Scottish
23 Unintentionally Gay Comic Book Scenes
Labels: 23 Unintentionally Gay Comic Book Scenes, comics, drawing, illustration, superhero, vintage
Janet Jackson! 19 Reasons We Are A Part Of The Rhythm Nation
She made this outfit look sexy
And that's no easy feat. There's a mix of Road Warrior meets Predator meets Tron happening here, but Janet could wear a hazmat suit and still kill it.
Labels: 19 Reasons We Are A Part Of The Rhythm Nation, actress, African American, child star, singer
Trump Plagiarized President Obama's Inauguration C...
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10 Protest Movies That Inspire Change In These Sca...
24 Times Drag Queens Perfectly Described How High ...
Vintage Vault: Robert La Tourneaux
50 BODIES THAT MAY OR MAY NOT BE BANGIN': AN INTER...
36 Fetishes Every Gay Man Should Know
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text:
Fine News
Calls for Tougher Asbestos Penalties
by Justin McGar
The federal government is being urged to consider increasing penalties for illegally importing asbestos.
CFMEU Stung $100K for Victoria Site Ban
Tuesday October 24 2017
The "militant" CFMEU has been fined almost $100,000 for banning contractors from a Victorian building site because they hadn't paid their membership fees but a judge...
Vic Builder Fined after Apprentice Death
Thursday September 7 2017
A Melbourne building company and its director have been fined $880,000 after an apprentice fell to his death at a construction site.
Quest Apartments in Perth Penalised for Sham Contracting
The former operators of Quest serviced apartments in South Perth have been fined almost $59,000 for a sham contracting arrangement designed to bypass industrial relations laws.
Steel & Tube Holdings Charged Over Mesh Claims
Steel & Tube Holdings is facing 29 court charges of making false and misleading representations about a steel mesh product.
John Holland Fined $280k for Work Incident
Tuesday May 30 2017
A leading Australian construction company has been fined $281,250 after a worker narrowly escaped being crushed at an Adelaide construction site.
CFMEU Fined $277k for Major Hospital Blockade
The nation's biggest building industry union and seven of its officials have been fined a total of $277,000 after being found guilty of illegally blockading the...
Window Glass Firm Hit with Million Dollar Penalty
Tuesday May 9 2017
A NSW window glass company has been hit with a massive $1 million fine for breaching workplace safety laws.
CFMEU Fines over Perth Blockade Increased
The construction union and some of its key leaders have been fined $242,000 for blocking work on the $80 million Perth International Airport expansion.
Vic Builders Fined $600K for Dumping
Developers who allegedly unlawfully knocked down a 159-year-old Melbourne pub have been fined more than $600,000 for dumping asbestos from the site to an area bordering...
Victorian Energy Regulator Warns AGL
Victoria's largest energy supplier AGL risks losing its licence to sell power in the state after the energy regulator issued a warning over the company's failure...
Building Union Court Fines Keep Climbing
Australia's construction union and two of its officials have been collectively fined more than $270,000 for breaching right-of-entry laws over a regional Victorian project, adding to...
Power Bills to be Based on Own Meter Reads
Power companies could face fines if they don't comply with a proposed new rule to allow people to read their own electricity meter rather than relying...
Victoria Developers Face Fine Over Vic Nylex Site
A property development group which owns Melbourne's historic Nylex clock silos site on the banks of the Yarra River has been given three weeks to carry...
Victoria Developers Charged for Blocking Roads
Developers who block arterial roads in inner Melbourne will be charged thousands of dollars under a new trial starting on Friday.
Construction Company Fined $140K After Worker Paralyzed
A Manitoba company has been fined $140,000 for a workplace accident in Saskatchewan that left a worker paralyzed.
Vic Agency Fined $880k for Underquoting
A Melbourne real estate agency that underquoted blue ribbon properties has been fined $880,000 - the largest penalty for underquoting in Victoria - for its cavalier...
Woolies Slugged $11m Over Masters Deal
Retail giant Woolworths has been ordered to pay more than $11 million to a Victorian property developer for breaking a contract for the construction of a...


The Sheng Xiao is another name of Chinese astrology which is focused around a twelve year cycle and every year in that cycle identified with a creature sign. These creature signs are the rodent, bull, tiger, rabbit, mythical serpent, snake, horse, sheep, monkey, chicken, canine and pig. It is ascertained as indicated by Chinese lunar timetable. You can utilize the apparatus on the right to hunt down your Chinese zodiac. Select your Gregorian date of conception, and you'll uncover your date of conception as per the lunar timetable together with your zodiac sign.
Like the ten wonderful stems and twelve natural limbs, creatures in Chinese zodiac were likewise made for considering years the framework that is presently all around acknowledged focused around the Christian timetable was up 'til now non-existent. The determination and request of the creatures that impact individuals' lives a whole lot was begun in the Han Dynasty and based upon every creature's character and living propensities. The division was done according to the old custom which was identified with number 12. Antiquated individuals watch that there are 12 full moons inside one year. Thus, its starting point is connected with stargazing. Every creature sign is typically related with a natural limb, so the creature years were called rabbit, bull, tiger, rabbit, horse, sheep, monkey, you chicken and puppy .
An extraordinary relationship between people and the 12 zodiacal creatures. It is accepted that the years spoke to by the creatures influence the characters of individuals in the same way as the indication of zodiac embraced by western human advancements.
Despite the fact that individuals think about the rodent not charming, and it even goes into unfavorable dialects, it positions first on the Chinese astrology. It has qualities of a creature with soul, wit, readiness, delicacy, adaptability and essentialness.
Positioned as the second zodiac, the bull is tremendous. In life, individuals regularly utilized it to show something huge in size or expansive in number. It is persevering, straightforward, legitimate, and clear. Irritable individuals are said to have a 'bulls temper'.
Tigers, recognized to be overcome, coldblooded, intense and startling, are the image of force and nobility. In old times, individuals typically contrasted sovereigns or grandees and the tiger. Court authorities frequently said that 'going with the head is much the same as being at the side of a tiger'. There are likewise numerous legends on chasing tigers managing battling against wickedness may.
The mythical beast delights in a high notoriety in Chinese society. It is the token of power, respect, honor, achievement, luckiness, and limit. In antiquated China, this animal was thought to speed over the sky with awesome force. Sovereigns entitled themselves solely as 'monster'; their thrones were called 'mythical beast thrones', their garments 'winged serpent outfits'.
In the Chinese zodiac, the Snake is recorded after the Dragon, however its place and its essentialness as an image of love is far short of what that of the Dragon. it conveys the implications of noxiousness, cattiness and secret, and in addition discernment, divination and the capability to recognize herbs. In a few spots, individuals accept that a snake found in their court can bring enjoyment. Throughout Spring Festival, individuals like to glue onto their entryways and windows the paper-cut "Fu" character (joy), joined with a snake turning around a rabbit onto their entryways and windows as a well known example demonstrating riches.


text:
Care for migrants is changing the world of religion
United Methodist delegates advance plan to maintain ban on same-sex marriage, LGBT clergy
The (Nashville) Tennessean: Deeply divided United Methodist delegates advanced a conservative plan out of committee to maintain the church's bans on same-sex marriage and gay clergy while dealing a potential setback to those pushing for full LGBT inclusion.
The New York Times: Why a vote on gay clergy and same-sex marriage could split the United Methodist Church
The church took a large step forward after abuse summit
National Catholic Reporter: It was unprecedented to gather the presidents of the world's episcopal conferences together on relatively short notice to address a specific problem.
The New York Times: The Catholic Church's 'ravenous wolves'
Impact investing and racial equity: foundations leading the way
Stanford Social Innovation Review: Foundations are deploying a wide range of impact investing strategies to advance racial equity in the United States.
Do Catholic universities still have a value proposition?
Inside Higher Ed: Catholic universities equip students to address big problems like poverty, hunger and injustice. But how can we articulate that mission in a way that is broadly appealing?
The Economist: Coping with the needs of migrants is catalyzing a change in the Western world's religious scene, and social scientists are taking note.


text:
Brentwood Baptist Church > About us
A Church where CHRIST is the Main Attraction!
Brentwood Baptist Church is a place of worship for all people. We provide a clear, practical Bible teaching ministry that applies to your current life. We make it easy for people to get connected and get involved. We welcome all ages, backgrounds and experiences. Our church strives to make Christ the MAIN attraction. We create an atmosphere of love, kindness, acceptance and truth. Always engaging music & worship to center your heart on God.
Dr. Joe Samuel Ratliff
Dr. Joe Samuel Ratliff was elected as pastor of Brentwood Baptist Church of Houston, Texas in February 1980 and by the year 2000 had grown it from a 500 member congregation to a mega-church of 12,000. The congregation has reached a plateau of more than 7,000 members with over 5,000 worshipers attending its two Sunday morning worship services…
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Albert A. Kemp
Albert A. Kemp is a native Houstonian. He received his High School Diploma from Ross Sterling. Rev. Albert Kemp was trained in a family where his father was a pastor of churches in Richmond, Rosenberg and Houston, Texas. Both grandfathers on his mother and father's side were preachers among other preachers and pastors in his family. He began his ministry of publicly proclaiming the gospel in 1977 under the late Rev. Dr. M.L. Price at Greater Zion Baptist Church, Houston…
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Facilities Management & Outreach
Rev. Williams, a native of Beaumont, Texas, is one of six children. Three of his siblings are pastors. He attended Starlight Baptist Church in Beaumont where he was a musician, playing the drums for nine years. Rev Williams moved to Houston in 1987 and united with Brentwood in 1988. He responded to his calling to the ministry in 1990, under Dr. Joe Samuel Ratliff's leadership. He completed studies at Southwest Baptist Theological Seminary…
Dr. C. Clay Pickens
Social Justice Advocate
The Reverend Dr. Carolyn Clay Pickens serves as Institutional Advancement Director of Brentwood Baptist Church. Dr. Pickens passionately shares the Word of God through her teaching, lecturing, and preaching. She is an advocate for criminal justice reform…


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text:
Фаэлан мак Колмайн (; умер в 666) — король Лейнстера (633—666), заложивший основы могущества рода .

Биография

Ранние годы
Фаэлан был одним из сыновей правителя Лейнстера Колмана Мара из рода Уи Дунлайнге. Родовые земли его семьи находились в долине реки Лиффи. Резиденция правителей этого небольшого лейнстерского королевства находилась в Майстиу (современном ).

В средневековой агиографической литературе рассказывается о том, что изгнанный своей мачехой, королевой Кайнех, из родного дома Фаэлан мак Колмайн был воспитан святым Кевином Глендалохским. Узнавшая о том, где нашёл убежище её пасынок, королева повелела разрушить обитель Кевина, но осуществить ей это так и не удалось. В легенде сообщается, что за намерение совершить подобной святотатство Кайнех постигла божья кара: она вскоре погибла, упав с высокой скалы вблизи Глендалохского монастыря. Это предание — воспоминание лейнстерских авторов о долговременном покровительстве, оказывавшемся правителями Уи Дунлайнге  Глендалохского монастыря. Известно, что брат Фаэлана, Аэд Чёрный, и его племянник Энгус мак Аэдо Финн были , что ещё больше усиливало власть королей Уи Дунлайнге над подвластными этим епископам землями. В ирландских сагах рассказ об изгнании Фаэлана передан иначе. В них сообщается, что Фаэлан был отправлен Колманом Мором под защиту святого Кевина, когда его супруга задумала убить своего пасынка, что король в гневе изгнал Кайнех, и что та умерла от горя в селении Слиаб Майге.

Первое упоминание Фаэлана мак Колмайна в  датировано 628 годом, когда в сражении с ним при Дума Айрхире пал король  (Южного Лейнстера) Крундмаэл Болг Луата. Возможно, помощь ему в войне оказал король Миде Коналл Гутбинн из рода , на сестре которого Фаэлан был женат. В записях анналов об этом событии Фаэлан упоминается как король всего Лейнстера, но вероятно, получение им этого титула следует относить к более позднему. Предполагается, что в 628 году Фаэлан был ещё только правителем небольшого королевства Уи Дунлайнге, располагавшегося в Северном Лейнстере.

Король Лейнстера
В 633 году Фаэлан мак Колмайн и его союзники, король Мунстера Файльбе Фланн и правитель Миде Коналл Гутбинн, одержали победу в сражении при Ат Гоане (к западу от Лиффи) над лейнстерским королём из рода  Кримтанном мак Аэдо. Правитель Лейнстера пал на поле боя. Вероятно, целью участников коалиции было свержение короля Кримтанна, покровительство которому оказывал их враг, верховный король Ирландии Домналл мак Аэдо. Начиная с этой даты Фаэлан упоминается в анналах как король Лейнстера.

Один из мунстерских трактатов утверждает, что король Файльбе Фланн выплачивал лейнстерскую дань Уи Нейллам, но  отверг это свидетельство как отражение позднейших мунстерских притязаний на власть над «половиной Муга» (Южной Ирландией).

В поэме  «Síl Aeda Sláne na Sleg», написанной в XI веке и сохранившейся в «Лейнстерской книге», сообщается о том, что короли-соправители Бреги Конгал мак Аэдо Слане и Айлиль Арфист погибли в сражении при Ат Гоане, вмешавшись в междоусобную войну в Лейнстере. Их победителями названы Фаэлан мак Колмайн и Коналл Гутбинн. Однако по свидетельству анналов, правители Бреги погибли в битве при Лох-Третине во Фремайнне (современном Лох-Дретине около Фревин Хилла в графстве Уэстмит), сражаясь с войском короля Миде. Эти исторические источники датируют гибель королей Конгала и Айлиля 634 годом и не упоминают об участии в сражении лейнстерцев.

В 645 и 647 году Фаэлан мак Колмайн вёл войну против правителя Уи Хеннселайг Колгу Болг Луаты. В анналах какие-либо подробности о причинах и ходе этого конфликта отсутствуют. Известно только, что король Колгу погиб в сражении в 647 году, но кто был его победителем, не указывается.

В 660 году в сражении с Фаэланом мак Колмайном погиб король Осрайге Фаэлан мак Крундмайл. Это третья крупная победа, одержанная Фаэланом над своими врагами. Все они способствовали усилению авторитета его рода Уи Дунлайнге, ставшего наиболее влиятельной силой Лейнстера.

В ирландской саге «Борома» сообщается, что вступивший на престол в 665 году верховный король Ирландии Сехнуссах мак Блатмайк из Сил Аэдо Слане сначала требовал от Фаэлана мак Колмайна выплатить ему традиционную дать скотом, а затем, когда тот отказался это сделать, вторгся с большим войском в Лейнстер. Несмотря на то, что в его войске были отряды из королевств Брега, , Айлех и Айргиалла, Сехнуссах в сражении при Лерг Мна Фине потерпел поражение от возглавлявшегося королём Фаэланом лейнстерского войска и был вынужден бежать с поля боя.

В «Лейнстерской книге» Фаэлан мак Колмайн наделён тридцатью годами правления. Предположительно, свидетельства о его смерти в анналах в 666 году основаны на этом или подобном королевском списке. Вероятно, что Фаэлан скончался от чумы, эпидемия которой охватила Ирландию в 664—666 годах. В то же время высказывается мнение о том, что Фаэлан мог умереть и ранее этой даты, например, не позднее 656 года, когда в сообщениях о смерти Крундмаэла Эрбуйлка тот упомянут как король Лейнстера. Вероятно, быстрому возвышению рода Уи Дунлайнге способствовал скреплённый родственными узами союз с правителями Кланн Холмайн, которые тем самым надеялись оказать давление на своих противников из . Преемником Фаэлана на престоле Лейнстера был Фианнамайл мак Маэл Туйле из рода Уи Майл.

Семья
Большинство правителей Лейнстера VII—XI веков принадлежали к потомкам короля Фаэлана мак Колмайна.

Известно о двух супругах Фаэлана мак Колмайна. Одной из них была Сарнат инген Эхах, принадлежавшая к лейнстерскому септу Фотайрт Феа, связанному тесными узами с епископами Килдэра. В этом браке у Фаэлана родился сын Коналл, отец лейнстерского короля Брана Мута. Другой женой Фаэлана была Уасал (умерла в 643 году), дочь короля Миде Суибне мак Колмайна и, таким образом, сестра Коналла Гутбинна.

Примечания

Литература

Короли Уи Дунлайнге
Короли Лейнстера
Правители Европы VII века
Умершие от чумы
Персоналии Ирландии VII века


text:
New laws target illegal gun trade
Issued: Tuesday, 27 October 2015
Tougher penalties will apply to illegal firearm offences following the Martin Place Siege, under proposed laws introduced to NSW Parliament today to combat the illegal gun trade.
Deputy Premier and Minister for Police and Justice Troy Grant today introduced the Firearms and Weapons Prohibition Legislation Amendment Bill 2015, which delivers on a commitment by the NSW Government in August to strengthen the state's gun laws.
"We are creating some of the toughest gun laws in the country and people who deal in or possess illegal guns are firmly in our sights,'' Mr Grant said.
"It's clear that the illegal gun market is where the threat to the community lies so that is our focus.''
The Bill:
Creates a new offence for the possession of a stolen firearm, which will carry a maximum penalty of 14 years' imprisonment;
Increases the maximum penalty for defacing or altering any identifying mark on any firearm or firearm part, or for possessing a defaced or altered firearm or firearm part, from five years to 14 years' imprisonment;
Applies consistent maximum penalties of 14 years' imprisonment to a range of other offences relating to unauthorised possession, use, supply, or acquisition of firearms where the firearm involved is a pistol, a prohibited firearm, or is defaced, unregistered or stolen; and
Includes a ban on the possession of digital blueprints that enable firearms to be manufactured using 3D printers and milling machines for anyone without an appropriate licence.
Mr Grant said the Bill will be supported by the creation of an Illegal Firearms Investigation and Reward Scheme. The scheme will offer rewards of up to $10,000 for information that leads to the arrest and conviction of a person for possession of an illegal firearm and will also fund police investigations, including undercover operations.
The package follows a recommendation of the Martin Place Siege Joint Review report, released in February, that the Commonwealth and the States and Territories should give further consideration to measures to deal with illegal firearms.


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2. Do these come in 50g packs? I can only see an available choice of 100g. Since I'm trying this out for the first time, I'd be more comfortable with a smaller pack.


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text:
Q: Is the momentum operator well-defined in the basis of standing waves? Suppose I want to describe an arbitrary state of a quantum particle in a box of side $L$. The relevant eigenmodes are those of standing waves, namely
$$ \left<x|n\right>=\sqrt{\frac{2}{L}}\cdot \sin \left(\frac{n\pi x}{L}\right)$$
In this basis, the operate $\hat{p}^2$ is diagonal by construction, so every state has a definite energy.
But suppose I want to construct this operator from the matrix elements of $\hat{p}$? These are ($\hbar=1$)
$$\left<m|\hat{p}|n \right>=-\frac{2imn((-1)^{m+n}-1)}{L\cdot(m^2-n^2)}$$
which vanishes for $m$ and $n$ with the same evenness, making this an off-diagonal "checkered" matrix.
I tried taking a finite portion of this matrix and squaring it in order to obtain $\hat{p}^2$, but from what I could tell, this yields an on-diagonal checkered matrix, contrary to the construction that it would be strictly diagonal.
I assume this has something to do with the fact that the wavefunctions obtained by applying $\hat{p}$ do not satisfy the same boundary conditions as the basis functions (do not vanish). Would this problem be solved I had taken the the infinite matrix in its entirety before squaring? Or is this entire problem (decomposing $\hat{p}$ in this basis) ill-defined?

A: The Hilbert space for a particle in a box has no associated momentum operator (as a momentum operator implies that the state space is invariant under space translations). So your attempt do define one leads to artifacts.
[Edit] In general, the Hamiltonian must be a densely defined operator on the physical Hilbert space. But a square well potential is too singular as an operator on the space of all square integrable functions on $R$ (i.e., no densely defined subspace is mapped by it into the Hilbert space), hence its Hilbert space cannot be the standard Hilbert space.
[Edit2] Note that the usual formula for the momentum is not a canonical momentum on the restricted space of wave functions defined only in the box, as it fails to satisfy either the commutation relation or does not preserve the boundary conditions.
The appropriate replacement for the momentum operator is the mode counting operator $\hat n$ with $\hat n|n\rangle=n|n\rangle$; see also the derivation of Qmechanic.

A: Applying $\hat p$ to a Hamiltonian eigenfunction gives another state indeed, but this state can be decomposed in the eigenstates of the Hamiltonian. Numerically it is good everywhere except, maybe, the boundary points, so for integration purposes such a decomposition (superposition) is good. You did not obtain a diagonal matrix exclusively because you took a finite matrix for $\hat p$.
EDIT: Yes, at $t=0$ you can form a wave packet moving in a certain direction from "plane waves" $\exp(i k_n x)$, as usual, and then you can replace each momentum eigenfunction $\exp(i k_n x)$ with a linear combination of sines (Hamiltonian eigenfunctions $\psi_m (x)$ with the corresponding time exponentials $\exp(−i E_m t),\; t>0)$. In particular, if you choose the largest possible wave packet with a certain momentum $\psi(x,t=0)\propto \exp(-ik_n x),\;0<x<L$, then in later moments it will not keep its form because of reflections and the momentum will not conserve.
EDIT 2: Any standing wave $\psi(x)$ on an interval $(0,L)$ can be decomposed into a superposition of the momentum eigenfunctions $ \exp(\pm|k_n|x)$. In our case the superposition contains only two running waves with certain momenta: $\sin(k_n x)=(e^{ik_n x}-e^{-ik_n x})/(2i)$, so the momentum operator exists and there is no problem here.

A: A geometric approach can be achieve via an orbifold construction.
I) Start with a free 1D quantum particle $\psi(x)=\psi(x+2\pi R)$ on a circle $S^1$ of circumference $2\pi R=2L$. The momentum $p=n\frac{\hbar }{R}$ is then quantized, $n\in\mathbb{Z}.$ The Hilbert space $H$ has momentum basis  $(| n\rangle)_{n\in\mathbb{Z}}$, where
$$\hat{p} | n\rangle~=~n\frac{\hbar }{R}| n\rangle, \qquad
\langle n| m\rangle~=~\delta_{n,m}, \qquad n,m\in\mathbb{Z}. $$
II) The orbifold
$$I ~=~ S^1/ \mathbb{Z}_2~=~ S^1/\sim$$
is an interval of length $L$. A position $x \sim -x$ is identified with the opposite position $x\in S^1$ via a  discrete $\mathbb{Z}_2$-group action. To implement the two Dirichlet boundary conditions
$$\psi(x=0)~=~0~=~\psi(x=L),$$
we impose that the wave function should be odd $\psi (x) = -\psi(-x)$. This kills half of the previous Hilbert space. The $\mathbb{Z}_2$-reduced Hilbert space $H/\sim~$ has basis  $(| n\rangle_{\sim})_{n\in\mathbb{N}}$, where
$$|n \rangle_{\sim}~:=~\frac{|n\rangle  - |{-}n\rangle}{\sqrt{2}}=-|{-}n \rangle_{\sim}, \qquad
{}_{\sim}\langle n| m\rangle_{\sim}~=~\delta_{n,m}- \delta_{n,-m}, \qquad
n,m\in\mathbb{Z}.$$
We can implement the orbifold construction through a parity operator $P$,
$$P\hat{x}P~=~-\hat{x}, \qquad P\hat{p}P~=~-\hat{p}, \qquad P^2~=~{\bf 1}, \qquad P^{\dagger}~=~P.$$
A ket state $|\psi \rangle~\sim 0 $ is identified with zero if it is even, $P|\psi \rangle= |\psi \rangle$. The new basis $|n \rangle_{\sim}$ is odd, $P|n \rangle_{\sim}=-|n \rangle_{\sim}$. The absolute value $\hat{|p|}$ of the momentum operator is a $P$-even (unbounded) operator. It is diagonal in the $| n\rangle_{\sim}$ basis,
$$ \hat{|p|}~ | n\rangle_{\sim}~=~ |n|\frac{\hbar }{R}| n\rangle_{\sim},\qquad  {}_{\sim}\langle n| ~\hat{|p|}~|m\rangle_{\sim}~=~  |n| \frac{\hbar }{R}~ {}_{\sim}\langle n| m\rangle_{\sim}\qquad
n,m\in\mathbb{Z}. $$

A: The operator is well-defined for instance in the position basis the operator corresponding to $\Psi(x) = \langle x | n \rangle$ is given by the ordinary form $\hat{p} = -i \hbar (d/dx)$ [*].
What happens is that $\Psi(x)$ are not eigenfunctions of the momentum operator $\hat{p}$ and, therefore, you cannot find a spectral decomposition of the operator in that basis (and, as a consequence, you cannot find a diagonal matrix).
Notice that $\Psi(x)$ are eigenfunctions of the operator $\hat{p}^2$ and it is possible to obtain the spectral decomposition
$$\hat{p}^2 = \sum p_n^2 | n \rangle  \langle n |$$
with the corresponding eigenvalues $p_n^2 = n^2h^2/4L^2$.
As a final note, it is not possible to obtain the matrix $\mathbf{p}$ from the matrix $\mathbf{p}^2$. First because the sign of $p$ is not defined and second because $\pm p$ does not correspond to a measurement of the momentum.
[*] By simplicity I am assuming one dimension.

redpajama_set_name: RedPajamaStackExchange


Is your dispensary compliant with security regulations?
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What is a medical marijuana card?


I ADORE home projects and repurposing things that some would otherwise throw away! I have had these chairs for 7 years and got them from a family friend who had them for 5 years prior. They are not antiques, but they are sturdy reliable but worn chairs…so I decided to repurpose them. Not only does this make them look unique and beautiful, but it added extra seating space!!!
I pulled each cushion off, pulled off the sliders on the feet (to replace them with new ones). I had pallets sitting around and cut the boards off and measured them perfectly. I cut each board to cover the entire area. This was my FIRST time using the table saw thanks to some help from my brother. The pieces don't match perfect in color but that is part of the beauty. Not to mention the stain will blend them more. I nailed the boards down and then inset them into the wood. I had to use a planer and belt sander to get the boards smooth and even. ( That took a while and super important that you inset them so you do not damage your tools while smoothing.) Make sure to clean the surface after sanding and then begin staining!
Once your stain dries you can seal it!!! I used Polyurethane and did two coats, but you can use your discretion as to how think you want it. Now I have a NEW beauty and a conversational piece!!
Be sure to visit my blog again and checkout my pinterest page as I try to upload as much of my own stuff as I can….MORE COMING SOON. Let me know what you think…..THANK you for visiting!!!
Thank you! I have been wanting to do this for a while and we just moved into our new home so it felt like the right time.
Wow, this is cool! Great job!


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Are you considering a business merger with another business in your area but you want to make sure the other business is as successful as yours? Do you want to verify that they aren't going under and they aren't trying to use your business to stay afloat? These are very important things that you need to look into, and a financial lawyer that specializes in working with businesses is the best option. Here are a few things you'll want your lawyer to comb through and create for you, so you are protected in the merger.
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Online reservations are coming soon.
Please use this form to make a booking enquiry.
When making a booking for one of our Theme Night Events or Pop-up restaurant events, we request a £10 non-refundable deposit per person to secure your booking.
To pay your deposit please call 01582 349690 to pay via debit or credit card, or please pop into the restaurant to pay by cash or send a cheque.
In addition to our restaurant we also have a lovely café open from 8.30am –3.30pm Monday to Friday (9.30am-2.30pm outside of term time) that provides a selection of homemade sandwiches, wraps, toasties and pastries for you to enjoy.
Please see below our sample menu – we look forward to serving you.
Click Here to download our menu.
© 2019 Hospitality Central, trading as The Chilterns.


text:
Compiling Dictionaries...
Compiling Dictionaries of Endangered Languages
Kenneth L. Rehg
The Oxford Handbook of Endangered Languages
Edited by Kenneth L. Rehg and Lyle Campbell
Linguistics, Sociolinguistics, Documentary Linguistics, Lexicography
2. How does one compile a dictionary?
3.1. Basic research
3.2. Applied research
4.1. Audience
4.2. The scope of the dictionary
4.3. Orthography
4.4. Staffing
4.5. Software selection
4.6. Other considerations
5. Dictionary design and construction
5.1. Macrostructure
5.2. Microstructure
5.3. Megastructure
6. Distribution and support
7. Legal and ethical issues
Introduction: Endangered Languages
The Status of the World's Endangered Languages
Assessing Degrees of Language Endangerment
Language Contact and Language Endangerment
Indigenous Language Rights—Miner's Canary or Mariner's Tern?
The Goals of Language Documentation
Documentation, Linguistic Typology, and Formal Grammar
The Design and Implementation of Documentation Projects for Spoken Languages
Endangered Sign Languages: An Introduction
Design and Implementation of Collaborative Language Documentation Projects
Tools and Technology for Language Documentation and Revitalization
Corpus Compilation and Exploitation in Language Documentation Projects
Writing Grammars of Endangered Languages
Orthography Design and Implementation for Endangered Languages
Language Archiving
Tools from the Ethnography of Communication for Language Documentation
Language Documentation in Diaspora Communities
Ethics in Language Documentation and Revitalization
Approaches to and Strategies for Language Revitalization
Comparative Analysis in Language Revitalization Practices: Addressing the Challenge
The Linguistics of Language Revitalization: Problems of Acquisition and Attrition
New Media for Endangered Languages
Language Recovery Paradigms
Myaamiaataweenki: Revitalization of a Sleeping Language
Language Revitalization in Kindergarten: A Case Study of Truku Seediq Language Immersion
Māori: Revitalization of an Endangered Language
Language Revitalization in Africa
Planning Minority Language Maintenance: Challenges and Limitations
Congruence Between Species and Language Diversity
Sustaining Biocultural Diversity
Traditional and Local Knowledge Systems as Language Legacies Critical for Conservation
Climate Change and Its Consequences for Cultural and Language Endangerment
Interdisciplinary Language Documentation
Why Lexical Loss and Culture Death Endanger Science
Funding the Documentation and Revitalization of Endangered Languages
Teaching Linguists to Document Endangered Languages
Training Language Activists to Support Endangered Languages
Designing Mobile Applications for Endangered Languages
Indigenous Language Use Impacts Wellness
Dictionaries play an essential role in documenting and conserving endangered languages. However, many such languages lack dictionaries, for a variety of reasons. A fundamental one is that relatively few linguists have had any training in lexicography. The purpose of this chapter, therefore, is to provide a preliminary guide to compiling a dictionary by envisioning that task as the production of a product. The creation of any successful product entails at least five steps—research, preliminary planning, design and construction, distribution, and support. Each of these steps is briefly discussed here, with an emphasis on dictionary design, described in terms of the dictionary's macrostructure, microstructure, and megastructure. Legal and ethical issues are also briefly considered. The primary goal of this chapter is to urge researchers to undertake the creation of a dictionary, and to provide them with a conceptual framework to do so.
Keywords: dictionary, lexicography, lexicographer, language documentation, language conservation
Kenneth L. Rehg is an Associate Professor of Linguistics at the University of Hawai'i at Mānoa (retired) and an authority on the languages of Micronesia, a region in which he has conducted fieldwork over the course of the past five decades. He is the (co)author of three books and numerous papers on these languages, founding editor of Language Documentation & Conservation, and the 2009 Chair of the Linguistic Society of America's Committee on Endangered Languages and their Preservation. His interests include language documentation, lexicography, phonology, historical linguistics, and the application of linguistics to the formation of educational policies and practices in the developing nations of the Pacific.


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Royal Berkshire Hospital
There is life after a stroke
On August 20, 2009, Jim Dowie, 49, suffered a stroke. Life for him and his long term partner Jules Boam changed forever
Natasha Adkins
Jim Dowie with his long term partner Jules Boam
The Reading Life After Stroke Support Group helps families across Reading borough to recover and understand the long term effects of stroke.
To raise awareness for Action on Stroke Month 2013 health reporter Natasha Adkins talked to a couple from Caversham who volunteer with the group having had first hand experience of how useful the service is
On August 20, 2009, Jim Dowie, 49, suffered a stroke. Life for him and his long term partner Jules Boam, 49, both of Chiltern Road, changed forever.
A stroke is a brain attack. It happens when the blood supply to the brain is cut, causing brain cells to die and resulting in brain damage.
"I was at home digging over the garden," explained Mr Dowie. "I went inside to have a sit on the sofa and my speech was slurred as if I had been drinking."
Although he was fortunate enough not to suffer long term physical effects with his mobility, Mr Dowie has ongoing cognitive issues that forced him to give up his job as a carpenter.
He said: "The fatigue was a big reason for why I gave up work but I also found that I was misinterpreting what clients wanted."
After spending two weeks in the stroke ward at Royal Berkshire Hospital (RBH) Mr Dowie was discharged but for several months spent up to 20 hours a day sleeping.
"I still have to break the day up, usually in the afternoon I will have a sleep," said Mr Dowie. "It is frustrating not being able to plan a whole day."
Despite the ongoing effects the couple considered themselves fortunate.
Stroke can affect anyone at any age. Reading has one of the highest rates of strokes in working age people.
Ms Boam said: "We are very lucky. In Reading we have the support we do, the Life After Stroke service is trusted by local medical professionals. They involve them with what is going on.
"Life After Stroke helps people with some of the non-medical challenges that come with stroke, like financial worries."
The couple found out about the Reading Life After Stroke Support Group when Mr Dowie was a patient at the RBH.
Within about three months of attending they signed up as volunteers.
Ms Boam said: "The group is for survivors and their families which is very important.
"It is reassuring to speak to other people going through a similar experience.
"When we first started going it helped us to be told arguing is common after someone has had a stroke."
Mr Dowie continued: "No stroke is the same. But talking about the different effects with other survivors and their families can make things seem a bit more normal."
The group meets at South Reading Youth Community Centre in Northumberland Avenue twice a month. Call Garry Jopling on (0118) 931 4534 or email garry.jopling@stroke.org.uk .
You don't have to feel alone
The emotional effects of stroke can be as devastating as the physical effects, according to a report published today by a leading stroke charity.
To launch Action on Stroke Month 2013, Stroke Association has revealed survivors and their families across the South feel abandoned when they leave hospital and left without the support they need to help them cope with the emotional impact of stroke.
However, thanks to a partnership between Stroke Association, Reading Borough Council and the two Care Commissioning Groups (CCGs), the Reading Life After Stroke service ensures there is hope.
The charity's report, entitled Feeling Overwhelmed, is based on the findings of a survey of 460 people from across the South.
It reveals 39 per cent of survivors said they felt abandoned after leaving hospital and 57 per cent had received no information or practical advice to help them cope with the emotional impact of stroke.
The Reading and Wokingham Life After Stroke Service provides high quality information, emotional support and practical advice in the aftermath and as long as people need it.
Garry Jopling, Life After Stroke co-ordinator for Reading and Wokingham, said: "This is a huge improvement on what was available in Reading a few years ago when many people who had a stroke felt very alone."
Caversham