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Health: What are the risks associated with injecting of Botox,the deadliest substance known to man?
For those fighting the losing battle against ageing, Botox injections have long been consider a risk worth taking.
A multibillion dollar industry, millions of people worldwide use the drug for cosmetic purposes, and beauty salons and clinics in Hong Kong charge between HK$3,000 and HK$10,000 per treatment as the image-conscious battle wrinkles, and crow's feet, in an attempt to maintain a youthful complexion.
Celebrities from Hollywood to Bollywood have been known to use it, although few admit it publicly. Nicole Kidman did confess to trying it on her face in 2011, and said it left her unable to form any expressions.
Nicole Kidman did confess to trying it on her face in 2011, and said it left her unable to form any expressions.
Temporary paralysis of facial muscles is one of several side effects, but a 2006 report claimed the drug was linked to 16 deaths, and this week Hong Kong saw its first case of Botox being suspected of playing a part in a death – that of Zoe Cheung Shuk-ling.
Dr Franklin Li Wang-pong, an 86-year-old plastic surgeon, was arrested over the incident, which has again raised concerns about the risks of this popular beauty treatment.
Botulinum toxin, or Botox as it is commonly known, is the most lethal substance known to man. Scientists have calculated that one gram of crystalline toxin, evenly dispersed and inhaled, could kill more than one million people.
But, it is types A and B that are used commercially and medically. Injections are commonly used in cosmetic procedures to reduce the appearance of wrinkles and fine lines on the forehead, between the brows and around the eyes. It also serves other medical purposes, such as treatment of severe underarm sweating and overactive bladders.
Dr Ho Chiu-ming, a specialist in plastic surgery, said the effects of an injection typically last for up to six months.
According to the Department of Health, people receiving Botox injection can develop difficulty chewing, swallowing, speaking or breathing. Those problems might happen hours, days or weeks after an injection. The US Food and Drug Administration added a safety warning in 2009 that said the toxin "may spread from the area of injection to produce symptoms of botulinum toxin effect", such as dropping of eyelids or blurred vision.
Ho said if the toxin was wrongly injected to some nerves or blood vessels, other problems such as bleeding or bruising could occur.
While the toxin can reduce wrinkles, he said it could also potentially limit a person's facial expressions.
Are serious side effects common?
Hong Kong recorded the first suspected case of botulism, a rare but serious illness caused by botulinum toxin, in 2016. A total of 13 such cases were recorded that year. There were three such cases in 2017, and there have been at least three this year. In most of those cases, people developed symptoms such as difficulty swallowing, generalised weakness, and shortness of breath, after receiving Botox injections for cosmetic purposes either in Hong Kong, or in mainland China. They had received injections in parts of the body such as the calf muscles or face.
What you should know before getting a Botox injection?
Botox injections in Hong Kong should only be performed by locally registered doctors. Ho said that aside from plastic surgeons, some other doctors such as specialists in dermatology and general practitioners also offered the service.
The specialist said if the injection was not performed by a medical practitioner, there could be concerns surrounding sanitation and the quality of the toxin used.
Apart from choosing a suitable person to perform the procedure, health authorities said people should also have a clear understanding of the procedure, and its potential risks and complications, before receiving an injection.
What regulations govern beauty treatments in Hong Kong?
Hong Kong does not have specific laws regulating beauty treatments. But a fatal beauty treatment blunder in 2012, in which a woman died after receiving treatment from beauty chain DR Group, has prompted the government to look into plans of regulating the medical beauty sector.
So far, the government has proposed the Private Healthcare Facilities Bill, which was passed by the Legislative Council on Thursday. The new ordinance aims to regulate four types of premises, namely hospitals, day procedure centres, clinics and health service establishments. The framework would cover the licensing scheme and regulatory requirements of those premises. Health minister Professor Sophia Chan Siu-chee said high-risk medical procedures performed there would also be regulated. A separate regulatory framework on medical devices is also expected to be submitted to Legco in this legislative session.


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The Wire: Seasons 1-5 Review
HBO crime shows have never been better since and this is a highly recommended show for a reason.
Plot: A complex HBO crime drama set in Baltimore that follows the thread of a single police investigation, from the perspectives of both law-enforcement officials and the criminals they're pursuing while focusing on the city's illegal drug trade, waterfront corruption and more!
Season 1:
The investigation is triggered when Det. Jimmy McNulty (Dominic West, Star Wars: The Phantom Menace) meets privately with Judge Phelan (Peter Gerety, Homicide) following the acquittal of D'Angelo Barksdale (Larry Gilliard, Jr., Trees Lounge) for murder after a key witness changes her story, after likely having been intimidated by members of a drug trafficking empire run by D'Angelo's uncle, Avon Barksdale (Wood Harris, Hendrix), having recognized several faces at the trial, notably Avon's second-in-command, Stringer Bell (Idris Elba in his star-making role). The Judge takes issue with this and complains to senior police figures, embarrassing them into creating a detail dedicated to investigating Barksdale. A dysfunctional, interdepartmental struggle between the more motivated officers on the detail and their superiors spans, with higher-ups threatening to ruin the investigation. The detail's commander, Cedric Daniels (Lance Reddick, Oz), acts as mediator between the two opposing groups of police.
Meanwhile, the organized and cautious Barksdale gang is explored through various characters. The organization is antagonized by a stick-up crew led by "Robin Hood" type thief Omar Little (Michael K. Williams, Bullet) and the feud leads to several deaths. The police have little success with street-level arrests or with securing informants beyond a young low-level dealer. Eventually the investigation takes the direction of electronic surveillance, with wiretaps and pager clones to infiltrate the security measures taken by the Barksdales. This leads the investigation to areas the commanding officers had hoped to avoid, including political contributions.
We're off to another show that made binge-watching a must before it was a thing. The whole show is rather compelling due to feeling entirely legit. It helps that most of the crew has already worked on other realistic shows such as Homicide and Oz, were former journalists and policemen and based many of the stories on actual events while barely changing them up. Despite being ignored by award shows, its critical acclaim is instantly merited due to the Law & Order style camerawork, Sopranos type montages and editing, and the inevitably colorful, slang-filled dialogue being well-delivered and occasionally darkly humorous. All of this helps to paint a bigger and often genuine picture of the actual Maryland city while allowing for much discussion after one's done watching it.
Following the ongoing examination of the drug problem and its effect on the urban poor, this season focuses now on the plight of the blue-collar urban working class as exemplified by longshoremen in the city port smuggling drugs and other contraband inside the containers that their port ships. Meanwhile, the Barksdale organization continues its drug trafficking with Stringer Bell assuming greater power.
While it was wise from a writing standpoint to have a change of scenery, the new Greek crime focus is arguably not as intriguing. Either way, some new recurring characters that appear in later seasons are scene-stealers and it helps that how the crimes are investigated and portrayed allow one to not find thus show anything like what they would find on network or basic cable TV. This also allows one to never find the show repetitive as no episode or subplot is ever the same.
The demolition of the towers that had served as the Barksdale organization's prime territory pushes their dealers back out onto the streets of Baltimore. Stringer Bell continues his reform of the organization by cooperating with other drug lords, sharing with one another territory, product, and profits. Stringer's proposal is met with a curt refusal from Marlo Stanfield (Jamie Hector, Ghost Dog), leader of a growing crew. Against Stringer's advice, Avon decides to take Marlo's territory by force, and the two gangs become embroiled in a bitter turf war with multiple deaths. Omar Little continues to rob the Barksdale organization wherever possible with his new boyfriend and two women.
Meanwhile, Councilman Tommy Carcetti (Aidan Gillen, Shanghai Knights) begins to prepare himself for a mayoral race by manipulates a colleague into running against the mayor to split the black vote, securing capable campaign manager and making headlines for himself. Coming to the end of his career, Major "Bunny" Colvin (Robert Wisdom, Coastlines) decides to achieve some real change in the neighborhoods by assuming the task of containing the problem without the knowledge of central command. He sets up areas where drug trade would go unpunished and cracks down on any traffic elsewhere, reducing crime rates in his district.
Season 3 is back to the rather fascinating Barksdales being the focus and this time it shows how both the police and top-dog gangsters are so out of line with what truly is happening in their territory. The filmmakers also present plenty more discussion worthy themes that parallel today's inept society without showing blatant imagery or showcasing a political agenda. What you've seen on this crime show, you have never seen portrayed this deeply in any other show, novel or movie. By wrapping up loose ends from the last two seasons with the gang war portion and inserting the social and political subplots, viewers only get anxious to see what the next season will detail.
The series expands its scope again to include an examination of the school system. Other major plots include: the mayoral race continuation and a closer look at Marlo Stanfield's drug gang, which has grown to control most of western Baltimore's trafficking.
Watching this season makes it far more relatable to all viewers, and probably the most personal season of the show to date. There is still the lovely crime detailing, drug trade, turf wars and city politics. But there is more at stake with the main school segments showing all the hard-working individuals of the city trying and often failing to do good things in their community. It is well contrasted with all the inept policymakers and flawed civilians who are distracted by easily avoidable circumstances. Overall, this is more of a companion piece to last season while having some small sections clearing the way for Season 5.
15 months after Season 4, Mayor Carcetti's cuts the police budget to redress the education deficit, forcing the Marlo Stanfield investigation to shut down. Det. McNulty decides to divert resources back to the police department by faking evidence to make it appear that a serial killer is murdering homeless men. The Baltimore Sun newspaper gets a hold of this "news" while also facing budget cuts and the struggling to adequately cover the city, omitting many important stories.
Marlo Stanfield learns how to launder money and evade investigation. After assuming power and forming an partnership with the Greeks and New Day Co-Op, he lures his enemy Omar Little out of retirement by having Omar's mentor murdered. Omar returns to Baltimore seeking revenge.
Some people like to talk smack about this final season by not agreeing with certain characters and their actions. And honest to goodness, they missed the damn point as this whole season is dedicated to showing how many wrongful individuals will face consequences for their actions. By having these numerous incarcerations, firings and sometimes shocking deaths of both sides of the law, the show fully hits home its message on how some members of modern-day society have evolved while others have refused to abide by any rules in a lawful society.
This show has been occasionally accused of being cynical but for starters, being blunt and being annoyed are two different things. And this show is called a "novel for TV" for a reason and it's because it did not shy away from showing a beyond organized tale of every layer of post-2001 society.

redpajama_set_name: RedPajamaCommonCrawl


Where is Bonifatius Treppe in Germany?
Bonifatius Treppe is situated in the region Hessen in Germany!
Here you will find the location of Bonifatius Treppe on a map.
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Where is Bonifatius Treppe on the map?
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Top 10 cities in Hessen and distance from Bonifatius Treppe.
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In 2011, there were over 95,000 seniors living alone in Toronto. Some seniors living alone may have difficulty taking care of themselves on a daily basis and do not have access to community help or support.
Public Health Nurses on the Vulnerable Adults and Seniors team respond to calls from family, community members and/or agencies with concerns about people living in challenging situations. The team provides services to vulnerable adults and seniors, with a focus on older adults over 55 years.
Complex physical and/or mental health problems.
Unsanitary or unsafe living conditions such as bedbugs and hoarding.
Increased risk for eviction or becoming homeless.
Limited or no financial means.
If you know of an adult or senior who needs help taking care of themselves, is living in poor conditions, and/or has limited supports, Toronto Public Health's Vulnerable Adults and Seniors team may be able to help.
Initiate contact with the client within three business days.
Help make a plan of action.
Follow up with appropriate services and supports.
* Please note that the nursing services we offer are voluntary and require the consent of the individual.


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Court Litigation
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Asset management is a huge economic sector in both developed and developing markets. It is a type of business created naturally following the success of enterprises, when such enterprises require more capital to deploy in their operation. On a larger scale, asset management is a need for both the investor and the company, bridging the rights and duties between the principal and the agent. The Vietnamese legal system in such a new situation is well prepared for each and every case evolving around corporate and investment matters, ranging from securities trading to board of directors disputes. These concerns have recently risen to a new significant level in Vietnam as the market is entering into its new phase of capitalism, where state-owned enterprises are gradually going through the process of privatization and foreign investments are growing.
Le & Tran is now a popular name among corporate and investment lawyers in Vietnam. We do not only build a strong team separately to focus on investment matters but also, we create a large network of professionals from other law firms and auditing and invesment companies as well, along with a good connection between our attorneys and corporate leaders. We have deep experience in assisting international and local investors with their investment in public and private securities, real estates, investment funds, and many other types of assets. We secure smooth transactions, prevent false information, verify sources of data, collect evidence and present documents. It is not difficult to find us working overnight or during weekend answering phone calls from clients or attending video conferences with brokers and traders. We work with private equity funds, hedge funds, mutual funds, pension plans, insurance companies and commercial banks in almost all stages of money management.
A typical case was when we claimed back tens of millions of dollars for a foreign institutional investor, as a result of our client's discovery that their investment in a local food manufacturer was not deployed in an economically efficient way and there were signs of embezzlement. Also, we protect local enterprises to avoid unnecessary mistakes and possibility of receiving illegal sources of capital, which is another hot topic recently as governments around the world tighten their laws in money laundering control. Not all cases we represent go to trial, and the majority of which are settled via arbitration and other methods of mutual agreement. In a case where the minority investors sued the brokerage house for improper buying and selling of securities without investors' prior permission, as it was impossible to bring the suit to court, we utilized a strategy of draining that brokerage house's power down to such a level that they have to seriously address our clients' request.
We look at matters with an eagle's eye, omitting no important objects and combining every single detail into our analysis. Our lawyers are more than mere people with legal background, we are experts in the field of professional investment and we understand the techniques of how to build a successful path for investing and managing your assets.
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"Dear esteemed clients,
We are delighted to announce:
LE & TRAN is the Winner for the Award "Dispute Resolution Law Firm of the Year in Vietnam - 2017" hosted by Global Law Experts (GLE).
The firm was also in the finalists of Asian Legal Business for the 2017 SE Asia Law Awards of:
Rising Law Firm of the Year (the sole Vietnam law firm in the list)
Vietnam Law Firm of the Year
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Dispute Resolution Boutique Law Firm of the Year


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Douglass Alumni Board Called Meeting 4/4/09
Here is a brief summary of the Douglass Alumni Board called meeting on Saturday, April 9th.
Board President Douglass Releford called the meeting to talk about some discrepancies in the Souvenir Booklet committee's organization.
President Releford was particularly dismayed over the Souvenir Booklet Committee's failure to submit at least three bids for the booklet's publication. He said, it appeaered that committee chairperson Linda Blye had already chosen someone to do the publication, when Releford had said the entire board had not voted on any bids submitted.
Chairperson Blye had convened a committee meeting a week ago (March 28th), and met with publisher Ricky Hancock, and members of the committee, who attended the called Board meeting, reported that Hancock had brought samples of his work, to which committee member Virginia Hankins said were "excellent.. they were better than good, they were great." Committee member Shelia Leeper, also present at the Hancock meeting, also said he does very good work.
Committee members also said that Hancock's price would be from 12 dollars to 15 dollars per booklet. They said Hancock related that the exact price would fluctuate between those amounts, depending on how many color pages were included (an all black-and-white booklet would be the minimum 12 dollars apiece). The Douglass Souvenir Booklet, of which there will be more information on soon, would obviously have some color pages in it. For an all-color booklet, the total price to the Douglass Alumni Association would be about $2,250, so the Board reasoned that the final price would be less than that, but that's what needs to be budgeted for the time being.
There was discussion on whether to just table the Souvenir Booklet activity until Chairperson Blye could bring all of her information to the full Board, including information and prices from at least two more bidders, but several board members and committee members remarked about the lateness of the situation, and that further postponements may delay the publication. Board member George Smith noted for future reference, that the Board needs to invoke proper procedure when dealing with situations like this, and press the need for all committee chairperson appointees to strictly follow the rules the Board has set down, to avoid any future confusion. Board members agreed, and President Releford said he did not have a problem with Mr. Hancock, nor the committee's report on his work, but that the situation did need to be discussed at this called meeting.
With no further discussion, the Douglass Alumni Board voted unanimously to hire Ricky Hancock to publish the Reunion Souvenir Booklet, of which sponsorship ads are already being sold.
The ad prices are 100 dollars for a full page, 50 dollars for a half-page and 35 dollars for a quarter page. Color ads are 10 dollars extra.
So far, ads have been sold to Eastman Chemical ($100), Citizens Bank ($110), Kingsport Times-News ($50.00), American Legion ($50.00), City of Kingsport ($50.00), the Sneed Family ($50.00), Child Development Center ($25.00).
In other business, Ozine Bly has paid Richard Ford of D-J Spontaneous for his services for the Reunion Sock-Hop, and the Reunion Banquet. He also brought to the Board a contract signed by himself and Mr. Ford, with the balance of the contract to be paid the weekend of the Reunion, July 4th.
Board member and Golf Tournament Chairman George Smith told the group, the tournament flyer is ready to be mailed out to potential golfers. He's expecting from 30 to 40 players this year.
There was no new business at the meeting, but Board member and website manager Calvin Sneed requested the full Board's presence on a field trip after the meeting, to the place where the old Douglass School books are being stored for the next School Book Fair. There is a special find that he's made, and is storing it along with the books, which will be good, uplifting news to all Douglass alumni. There will be a story on the find very shortly!
The next scheduled Douglass Alumni Board of Trustees meeting will be at St. Mark's Methodist Church on April 18, 2009 at 1 PM. The meeting will be a pot lunch.
Ebony Club Alumni: REGISTRATION DEADLINE
Neighborhood Watch group to meet Monday
New Vision to host Youth Prom June 6th
Racist Graffiti Discovered in Kingsport
SPECIAL NOTE: The Douglass Reunion Souvenir Book ...
"And the Walls Came Tumbling Down:" The Douglass ...
Douglass Alumni Trustee Board Meeting, 4/18/09
Easter Egg Hunt Pictures
Carolyn Flack in Rehab
Kingsport Negro League game had plenty of Clowning...
Douglass Alumni Trustees Board Meeting CHANGE
Destruction of Riverview Appalling
Riverview Resident Is Ready For Her New Youth Buil...
East Tennessee Politics
"The Day The Music Died:" Our Historic Douglass Au...
Riverview's Easter Egg Hunt: "An Egg-straordinary...
Don't Forget - Easter Egg Hunt on Saturday
Check Out The HOPE VI Pictures--Let's Finish Namin...
New Pictures The Day Dr. King Was Assassinated in ...
Youth In Praise: "Putting the Young People in Cha...
Kingsport Finishing First Phase of HOPE VI Project
Easter Egg Hunt To Be Held at V.O. Dobbins
"De-line-ating"


Regularity and navigation with motorbike, we have listened to you from the beginning.
For both, routes with roadbook and regular competition, Rallymeter helps you to achieve your goals.
The safety and simplicity of use is an extra point when we talk about the bike. Rallymeter is designed so you can navigate and keep pace without losing sight of the road. With the bike specific blackBox hardware you can have an external pushbutton for adjustments without having to manipulate the screen in progress.
Enter times and distances of link to be able to arrive in time at the start of the next section. Program the 'carnet de route' and you will have the calculation of the departure times in a single click.
Add as many averages as you need (up to 999).
References of roadbook with or without photo to facilitate navigation and / or adjust step distance with a press, in this case an external pushbutton if using blackBox.
References of road-book cells with or without photo to facilitate the navigation and/or adjust distance with a press.
The simplest calibration system on the market.
Changes of average by reference (milestones).
Mode tables to be able to predict times of passage by the distances imposed. With the possibility of varying the prediction distance manually during the section.
Mix average changes with average changes by reference or imposed time sectors (tables).
Speed table mode "on the fly" that allows to start without programming any stage and make the changes of average manually in case they give us the information of the stage just when starting, with no time to program it.
Ability to freeze the distance measurement to check references.
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El 7° Rallye Xaló se disputó bajo unas condiciones climatologicas muy cambiantes que hicieron muy complicada la tarea de seguir las medias..
José I. García Bejarano- Jose Ignacio Garcia Ojeda ganan el rally Sierra Morena en Regularidad Sport. Enhorabuena!
Ayer, en el XII Rallye Ciutat de Gandia, rallye duro, bonito y disputado, se impusieron con autoridad en Regularidad Sport, Javi Fraces – Aaron..


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Q: How to measure total memory usage by some R code with parallel computing on Mac OS? Basically I want to measure the total memory used by following R code on Mac OS. I know there is a handy python app syrupy that can take snapshots of the memory and CPU load of one or more running processes.
require(glmnet)
require(doMC)
registerDoMC(cores=4)
x = matrix(rnorm(1e5 * 100), 1e5, 100)
y = rnorm(1e5)
system.time(cvfit = cv.glmnet(x,y,parallel=TRUE))

Suppose I put above code in an R file named test_memo.R. I can use following command to measure the memory:
syrupy.py Rscript test_memo.R

This works fine if for serial computing. However, for parallel computing it appears to me that this app can only capture the memory used by just one process/thread/core, not not the total.
Could anyone tell me how to measure the total memory for the parallel-computing mode? Any solutions other than syrupy are highly appreciated!
Thanks in advance.

redpajama_set_name: RedPajamaStackExchange


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RENAL DATA FROM ASIA-AFRICA
Acute renal failure in children in a tertiary care center
Malobika Bhattacharya, Dhulika Dhingra, Mukta Mantan, Sukesh Upare, Gulshan Rai Sethi
Department of Pediatrics, Maulana Azad Medical College and Associated Hospitals, University of Delhi, Delhi, India
In this retrospective study, records of all patients aged one month to 12 years who presented with acute renal failure (ARF) between May 2005 and August 2010 were retrieved. Clinical details, biochemistry, need for renal replacement therapy (RRT), cause of ARF and outcome at discharge were recorded. During this period, 230 children presented with ARF; their median age at presentation was 30 months (range: five-144 months); 120 (52.2%) were males. The causes of ARF were acute tubular necrosis (ATN) in 121 (52.6%), glomerular disorders in 5.7%, structural anomalies of the urinary tract in 9.6% and hemolytic uremic syndrome in 27 (11.7%). The mean duration of hospital stay was 17.8 ± 7.6 days. RRT was required for 54 patients (23.6%); peritoneal dialysis in 49 and hemodialysis in five patients. Complete recovery was noted in 99 study patients (43.2%) and sequelae remained in 84 patients (36.7%). Forty-six patients (20.1%) with ARF died. ATN secondary to septicemia was the most common cause of ARF in our study.
Bhattacharya M, Dhingra D, Mantan M, Upare S, Sethi GR. Acute renal failure in children in a tertiary care center. Saudi J Kidney Dis Transpl 2013;24:413-7
Bhattacharya M, Dhingra D, Mantan M, Upare S, Sethi GR. Acute renal failure in children in a tertiary care center. Saudi J Kidney Dis Transpl [serial online] 2013 [cited 2020 Jan 23];24:413-7. Available from: http://www.sjkdt.org/text.asp?2013/24/2/413/109620
Acute renal failure (ARF) is characterized by a rapid deterioration of renal function resulting in retention of nitrogenous wastes and other fluid and electrolyte derangements, which are usually reversible. [1] In the absence of a universally accepted definition, and in recognition that ARF actually includes a spectrum of clinical conditions, the term acute kidney injury (AKI) has recently been proposed for the entire spectrum of the syndrome. More recently, a classification of AKI has been proposed based on the serum creatinine and urine output [2] [Table 1]. The incidence of ARF in neonatal and pediatric units varies between 10 and 25%, depending on the criteria used for its definition. [3],[4] The etiology of ARF may be pre-renal, intrinsic renal or post-renal and has changed over the past decades from primary renal diseases to multi-factorial causes. Despite advances in therapy, mortality due to the condition is still high (30-40%) and a proportion of patients may progress to chronic kidney disease and dialysis dependency. [1] The present study was undertaken to identify the causes and short-term outcome of ARF in a pediatric tertiary care center located in Northern India.
Table 1: RIFLE staging of acute kidney injury/AKIN*.
This retrospective study was conducted in the pediatrics department of a tertiary care hospital. The study was approved by the institute's ethics committee. Records of all children aged one month to 12 years, diagnosed with ARF during the period of May 2005 to August 2010, were retrieved. ARF was diagnosed on the basis of acute worsening of renal function as evidenced by rising blood creatinine with or without decreased urinary output.
Neonatal and post-operative ARF were excluded as patients with these conditions were not admitted to the pediatric wards. Patients with dehydration, oliguria and deranged kidney function that corrected promptly on rehydration were also excluded.
Details of clinical features, etiology, biochemical parameters, treatment including the need for renal replacement therapy (RRT), duration of hospital stay and outcome were noted from the retrieved records. Presence of anemia, hypertension, edema, encephalopathy and seizures was recorded. The biochemical parameters noted were blood urea, serum creatinine, electrolytes, venous blood gas and bicarbonate levels. The causes of ARF were assigned using standard definitions and only the primary cause of ARF was included. Short-term outcome was defined as the condition at discharge. Data were analyzed using descriptive statistics of the excel program.
The study included 230 children with ARF, either at admission or acquired during stay in the hospital. ARF was diagnosed based on pRIFLE criteria [Table 1]. [2] The median age of the study population was 30 months (5-144) and 120 patients (52.2%) were boys. Eighty-four patients (36.5%) were aged less than one year whereas 78 (34%) were aged between one and five years. Oliguria was present in 100 children (43.5%) with a mean duration of 82.5 ± 35.7 h. Hypertension was detected in 62 patients (27%) while encephalopathy or seizures was present in 24 patients (10.4%). The mean peak blood urea and serum creatinine concentrations were 155.3 ± 70.6 mg/dL and 4.3 ± 3.2 mg/dL, respectively. The mean urea and creatinine levels at discharge were, respectively, 79.3 ± 51.2 mg/dL and 2.12 ± 2.3 mg/dL. The mean duration of hospital stay was 17.8 ± 7.6 days.
Causes of ARF
The principal causes of ARF were acute tubular necrosis (ATN) in 121 (52.6%), glomerular disorders in 13 (5.7%), structural anomalies in 22 (9.6%), hemolytic uremic syndrome (HUS) in 27 (11.7%) and nephrolithiasis in eight patients (3.5%). The distribution of causes of ARF according to age is listed in [Table 2]. The major causes of ATN were sepsis in 71 (58.7%), acute gastroenteritis in 35 (28.9%) and Plasmodiumvivax malaria in seven patients (5.8%). Of the 71 patients with sepsis-related ATN, 37 patients (52.1%) were blood culture positive. The isolated organisms included Escherichia More Details coli in 12 (32.4%), coagulase-negative Staphylococcus in two, Klebsiella species in nine, Pseudomonas in four and Staphylococcus aureus in ten patients.
Table 2: Distribution of etiology of acute renal failure according to age (n=230).
Four patients with congenital heart disease presented with cardiogenic shock and ARF. Intravascular hemolysis was the cause of ATN in two patients and both were G-6-PD deficient. Of the 27patients with HUS, 19 had dysentery (D+). Stool cultures were positive in 18 patients, and organisms isolated included E. coli in eight (44.4%), Klebsiella spp. in four, Proteus in three and Shigella dysentriae in three patients. Common associations with D-HUS were pneumonia in four and meningitis in two patients.
Renal replacement therapy and outcome
RRT was required in 54 patients (23.5%) and 49 patients (90.7%) underwent peritoneal dialysis (PD). The average duration of dialysis was 65.3 ± 38.7 h and the main complication of PD was peritonitis, seen in 11/49 patients (22.4%). Dialysis was more frequently required in patients with acute on chronic renal failure, 8/18 (44.4%); urolithiasis, 6/8 (75.0%); HUS, 16/27 (59.3%); vasculitis, 3/3 (100%); and structural anomalies of the urinary tract, 5/16 (23.8%). Complete recovery was seen in 99 patients (43.2%) with ARF and sequelae such as persistent deranged renal functions, hypertension or proteinuria were present in 84 patients (36.7%). Forty-six patients (20.1%) with ARF died. The short-term outcome based on the etiology of ARF is summarized in [Table 3].
Table 3: Etiology of acute renal failure and survival rates.
Higher mortality (26.2%) was observed in children below one year of age. Also, mortality was higher in children with HUS (40.7%), sepsis (37.3%) and those managed in the intensive care setting (39.0%).
Of the 230 patients with ARF, information on renal ultrasound was available for 199 patients. One hundred patients (50.3%) had normal kidneys on ultrasound. Dilated renal collecting systems were seen in 20 patients (10.1%), normal sized kidneys with altered corticomedullary differentiation (CMD) in 45 (22.6%), enlarged kidneys with altered CMD in seven (3.5%) and enlarged kidneys with maintained CMD were seen in three patients (1.5%). Twelve patients had bilateral small kidneys on sonography (those with acute on chronic renal failure). Two patients had nor-mal sized single kidneys, two children each had renal tumors and multiple renal abscesses and six children had nephrolithiasis. In the two children with nephrolithiasis, X-ray (KUB) also showed renal calculi.
Because of the lack of a uniform definition of ARF until recently, most studies of the past are relatively heterogeneous and the incidence of ARF has varied from 10 to 40% among hospitalized children. The causes of ARF have changed in the last decade. Studies in the 1970s and 1980s demonstrated that intrinsic renal diseases including HUS and glomerulonephritis were the most common causes of ARF in children. Most studies from the developed world presently report ARF from surgical, transplant and intensive care units. [2] Information on pediatric ARF is relatively scant from our country. Hence, this study was conducted aimed at identifying changes in the etiology of pediatric AKI in the recent years as well as its short-term outcome.
Of the 230 subjects studied, 162 (70.4%) were below five years of age. In the previous studies also, ARF had a maximal incidence in children under five years of age. [2],[5] Increased occurrence of diarrhea and septicemia in young patients could be the major reason for this age distribution.
The most common cause of ARF in this study was ATN, seen in 52.6% of the patients. The primary cause of ATN was sepsis, seen in 58.7% of the patients and acute gastroenteritis in 28.9% patients. These results are compa rable to other studies from developing countries. It seems that even with passing decades, the etiology of ARF in our country has changed little. [5],[6] In a recent study from North India, sepsis was the cause of ARF in 33% patients. [7] This could be due to poor hygiene and lack of sanitation, still prevalent in a large proportion of the population.
The incidence of HUS has decreased as compared with previous decades. In a previous study from the same city, the reported prevalence was 36% as against 11.7% in the present study. [8] Availability of better antibiotics and an overall decrease in the incidence of dysentery in the population could be responsible for this change. Most cases of HUS (70.4%) were associated with dysentery, and E. coli was the most common causative agent.
Sonographic findings were abnormal in 49.7% patients and the most common abnormality detected was altered CMD, seen in 22.6% patients. Utility of sonography in ARF is primarily limited to the identification of obstruction, urolithiasis and differentiation from chronic kidney disease. [9] The implications of altered echo texture in an acute setting are not known.
RRT was required in 23.5% patients, and the main modality of dialysis used was PD in 90.7% of the cases. The catheter used for peritoneal access in all these patients was a stiff catheter. The reasons for greater use of PD were its easy availability, requirement of lesser expertise and also a younger age group of patients (almost 70% were below 5 years of age). The higher incidence (22.4%) of peritonitis among these patients could be due to use of stiff catheters and prolonged duration of acute dialysis. Patients who underwent hemodialysis were older and also required dialysis for prolonged periods. While continuous RRTs are being increasingly used in intensive care patients in the western world, its usage in the pediatric population in our country is extremely low due to nonavailability at most centers. [2],[9],[10]
The overall mortality was 20.1% in this study. The factors associated with higher mortality were age at onset below one year, HUS as the underlying diagnosis and admission to intensive care unit. Other studies on AKI have also shown a mortality of 20-30% and a better survival beyond infancy. [5],[7],[11]
The eventual recovery and the long-term outcome of patients with ARF chiefly depends on the underlying condition. While the prognosis in ATN, acute interstitial nephritis and glomerulonephritis, is satisfactory, patients with multi-organ failure and cortical necrosis fare poorly. [12],[13]
A major limitation of our study is the lack of information regarding the occurrence of ARF from the pediatric surgical and cardiothoracic units. It is possible that with the rising number of pediatric surgeries, the incidence of ARF has increased in these settings as well.
To conclude, ATN consequent to septicemia was the most common cause of ARF in this study. RRT was required in 23.5% patients and PD was the mainstay of RRT in our patients.
1. Moghal NE, Brocklebank JT, Meadow SR. A review of acute renal failure in children: Incidence, etiology and outcome. Clin Nephrol 1998;49:91-5.
2. Hui-Stickle S, Brewer ED, Goldenstein SL. Pediatric ARF Epidemiology at a Tertiary Care Center from 1999-2001. Am J Kidney Dis 2005;45:96-101.
3. Agras PI, Tarcan A, Baskin E, Cengiz N, Gurakan B, Saatci U. Acute renal failure in the neonatal period. Renal Failure 2004;26:305-9.
4. Srivastava RN, Bagga A, Moudgil A. Acute renal failure in north Indian children. Indian J Med Res 1990;92:404-8.
5. Agarwal I, Kirubakaran C, Markandevulu V. Clinical profile and outcome of acute renal failure in South Indian children. J Indian Med Assoc 2004;102:353-4.
6. Srivastava RN, Moudgil A, Bagga A, Vasudev AS. Hemolytic uremic syndrome in children in northern India. Pediatr Nephrol 1991;5:284-8.
7. Nasir SA, Bhat MA, Hijaz SW, Charoo BA, Sheikh BA. Profile of acute renal in children in Kashmir. Indian Pediatr 2011;48:491-2.
8. O'Neill WC. B-mode sonography in acute renal failure. Nephron Clin Pract 2006;103: C19-23.
9. Ronco C, Bellomo R, Ricci Z. Continous renal replacement therapy in critically ill patients. Nephrol Dial Transplant 2001;16(suppl 5):67-72.
10. Goldstein SL, Somers MJ, Baum MA, et al. Pediatric patients with multi-organ dysfunction syndrome receiving continuous renal replacement therapy. Kidney Int 2005;67:653-8.
11. Pundziene B, Dobiliene D, Rudaitis S. Acute kidney injury in pediatric patients: Experience of a single center during an 11 year period. Medicina (Kaunas) 2010;46:511-5.
12. Radhakrishnan J, Kiryluk K. Acute renal failure outcomes in children and adults. Kidney Int 2006;69:17-9.
13. Arora P, Kher V, Rai PK, Singhal MK, Gulati S, Gupta A. Prognosis of acute renal failure in children: A multivariate analysis. Pediatr Nephrol 1997;11:153-5.
Mukta Mantan
Department of Pediatrics, Maulana Azad Medical College, Delhi 110002
[Table 1], [Table 2], [Table 3]
1 Épuration extrarénale en réanimation adulte et pédiatrique. Recommandations formalisées d'experts sous l'égide de la Société de réanimation de langue française (SRLF), avec la participation de la Société française d'anesthésie-réanimation (Sfar), du Groupe francophone de réanimation et urgences pédiatriques (GFRUP) et de la Société francophone de dialyse (SFD)
Christophe Vinsonneau,Emma Allain-Launay,Clarisse Blayau,Michael Darmon,Damien du Cheyron,Théophile Gaillot,Patrick Honoré,Étienne Javouhey,Thierry Krummel,Annie Lahoche,Matthieu Legrand,Serge Le Tacon,Mehran Monchi,Christophe Ridel,René Robert,Frédérique Schortgen,Bertrand Souweine,Patrick Vaillant,Lionel Velly,David Osman,Ly Van Vong
Réanimation. 2014;
Bhattacharya M
Dhingra D
Mantan M
Upare S
Sethi GR


There are so many things I don't have to remember, because they're readily available on the internet, through my phone or computer, that I wonder how it's affecting my memory use in general... and what about my students' memory use?
How do the changes in the way we are using memory affect the new generation with their reading process? If we can identify these changes, how can we address these shifting needs in our teaching?


Just hours after getting off a plane from Paris, me and my crew recorded this video for the NPR Tiny Desk contest - check it out and let me know what you think!
Me and Edson Sean, my closest collaborator, embarked on a whirlwind trip to Europe. Barcelona, Marrakech, Berlin, Amsterdam and Paris were our stops. Where should we go next time?
From October to November, YOU helped me make my dreams come true by supporting my Afro Ratchet Soul Indiegogo campaign. It's done now (though you can ALWAYS donate to my cause) and I'm in the midst of bringing this masterpiece to fruition. Stick with me on the journey via IG.
Welcome to my digital artistic home! Take a moment to listen, look, shop and feel. I hope you find yourself filled with peace + joy, and that you're inspired to invite others on this journey we're taking into finding, creating and redefining beauty everywhere.
ArinMayaMade is my line of handcrafted jewelry and accessories designed with a commitment to sustaining and honoring earth, style, spirit and self. Inspired and created in Brooklyn, NY.


FREE DOTERRA LIFELONG VITALITY PACK!
So I don't usually talk about anything other than the essential oils in doTERRA's product range, however THESE guys need mentioning.
I've never been big on vitamins and supplements, in fact I've avoided taking tablets for quite a few years now. I'm still not a raving fan of poppin' pills, however my stubbornness doesn't change the fact that the majority of the population are nutrient deficient and have chronic inflammation in their bodies. I wouldn't be doing anyone a favour by keeping this information from you.
These supplements are regularly on my Loyalty Rewards order.
Called the Lifelong Vitality Pack (LLV), these are a range of supplements that actually surpass all of doTERRA's single oil sales making them the #1 best selling product…! Not that surprising though with some of the results they create. Not only are they TGA approved (PDF here) they are also available to be rebated through some health insurance policies now.
These supps have benefits such as: INCREASED ENERGY, DEEPER SLEEP, EMOTIONAL STABILITY, MUSCULAR SKELETAL SUPPORT.
In a study conducted on these exact supplements, participants reported "more mental clarity, energy, motivation, control, balance, and happiness, while reporting less back pain, muscle pain, cold and flu incidence, anxiety, frustration, and irritation at the end of the two-month supplementation period."
Check out this study here.
I don't think it's a coincidence that I was feeling my lowest and and not sleeping properly when I had run out of these for about 5 days last year. I've been pretty sporadic taking them over the past 6 months as well and I've definitely noticed a lack of energy and increased feelings of anxiousness. I've been taking these supps for just 7 days now and I already feel like I have more energy and stable moods.
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While not all companies have embedded leases, industries such as banking, retail, manufacturing, restaurant, energy, healthcare and logistics/transportation tend to have a greater number of service contracts with embedded leases.
Currently, service contracts with embedded leases aren't treated any differently than those without. New FASB lease guidelines require companies to divide the contract into the lease and non-lease components. Then, the embedded leases must be recorded in order to circumvent material misstatements.
How to identify embedded leases?
First, pinpoint any identified assets in the contract. In doing so, identify if it is explicit, when the asset is actually identified in the service contract, or implicit, when the only way the contract obligations can be satisfied is to utilize the asset.
Second, decide if the lessee gains control of the asset and all its economic benefits.
If there is identification, control, and the company acquires the economic benefits, then it is a lease.
Where are embedded leases found?
What makes the new rules related to embedded leases difficult?
Well, the FASB included practical measures declaring it's not necessary for companies to re-evaluate expired or existing contracts, however, there is one caveat: errors are not exempt from the new rules. But how does a company know its service contracts are error-free without re-evaluating? The new rules assume companies have error-free contracts, yet these contracts are the ones that have historically been given very loose treatment. Therefore, companies have to comprehensively review all service contracts to confirm they have a complete record of all embedded leases. To help ensure embedded leases are identified and properly recorded, companies can rely on CoStar's feature-rich lease accounting and lease management software.


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GAIA is an organic and all natural skincare company, proudly owned and operated by two Aussie parents! Their frustration grew when they couldn't find the appropriate treatment on the market, for their son's eczema, so they decided to create their own! Their products are formulated with sensitive skin in mind, and are designed for everyday use! With no nasty ingredients, or artificial fragrances, the low price tag is just a bonus!
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Lovely oil with natural ingredients.
Fantastic repurchase for my son's sensitive skin.


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Sunderland on the verge of completing Edouard Michut deal
3 minute read 28/8/2022 | 11:04am
An update has emerged on Sunderland and their pursuit of Edouard Michut in the summer transfer window…
Italian journalist Fabrizio Romano has revealed that the Black Cats are set to sign the attacking midfielder before the deadline on Thursday.
He Tweeted: "Excl: Edouard Michut leaves Paris Saint-Germain and joins Sunderland, done deal. Full agreement in place on initial loan move with buy clause around €5m and future sale percentage. #PSG …and Michut is already at the stadium right now, to follow #SAFC game."
The Chronicle's James Hunter confirmed the last part of Romano's claim, Tweeting: "#safc transfer target PSG midfielder Edouard Michut is here today. He is sitting below us in the directors' box at the SoL."
Dreyfus could sign Neil a big Gooch upgrade in Sunderland swoop for "unbelievable" gem - opinion
Sunderland eyeing £13k-p/w gem who "plays out of his skin", he's an upgrade on Gooch - opinion
Sunderland could land big Roberts upgrade by signing 80 G/A gem with "eye for a goal" - opinion
Sunderland make contact over signing "hungry" 6ft1 gem, he could be a Speakman blinder - opinion
Kristjaan Speakman blinder
Sunderland have made seven additions to their squad so far this summer and Speakman is now pulling off a blinder with their soon-to-be eighth arrival.
Will Michut be a good signing?
It was reported that Scottish giants Celtic, who are in the Champions League this year, and other teams in Europe were interested in signing the midfielder, which highlights the level of competition the club have beaten off to land Michut.
The Black Cats have only been out of the third tier for a few months and are already showing the pull that they can have in the transfer market. It shows that players are aware of the size of the club and believe that the potential is there for the Stadium of Light to host Premier League football once again in the future.
Sunderland's incredible support could help to persuade players. They have averaged 38,392 fans per home game this season in the Championship, which is over 10,000 more than Sheffield United and Norwich in second and third when it comes to attendance.
However, it may also be down to Speakman's power of persuasion in negotiations as he has clearly convinced the player that a move to Wearside is the best next step in his development.
Starting off easy... who was Sunderland's top scorer in 2021/22?
Pritchard
Football talent scout Jacek Kulig claimed that he has "natural football IQ" and once dubbed him "highly technical and creative", which suggests that he could add a touch of quality in possession.
His eight first-team appearances for PSG by the age of 19 also suggest that he has a lot of potential as he has been deemed ready to feature for the French champions in Ligue 1.
Therefore, this move is a blinder as Speakman is bringing in a talented, sought-after, young player with the scope to develop as he gains more experience.
The initial loan also covers Sunderland from a financial point of view as they can send him back to PSG if the move does not work out, which prevents the club from splashing out a significant fee if he struggles to adapt to English football.
This is another reason why Speakman has pulled off a masterclass with this deal and hopefully, Michut will now be able to back that up with excellent performances on the pitch this season.


It was just a scrimmage. Just a coach evenly pitting half of his team against the other half with even the walk-ons contributing. Merely 24 minutes of intersquad Arizona basketball. Simply a glorified event, a promotional spectacle, meant to generate excitement and buzz surrounding the Wildcats' upcoming season.
Excitement galore as the 1994 Final Four team – with two former players now on the current coaching staff – was honored. Arizona's video production team agaub did a phenomenal job cutting up the history of the school's signature program and setting it to tunes that make you go goosebumps. Lute Olson was there and the current team was introduced to the enthusing sounds of John Williams' 2001: A Space Odyssey. Sean Miller set cheering sections by name dropping every retired jersey in program history.
Hell yeah I watched a basketball practice.
Yet you can't really take much away from two, twelve-minute halves of pageantry. I greatly appreciate Kaleb Tarczewksi's 18 points and Rondae Hollis-Jefferson's length and ability to slash. Brandon Ashley showed flashes of dominating moves en route to 14 points and 12 rebounds. A dynamic post he shall become. I finally got to see TJ McConnell play defense and I enjoyed it.
Conclusions aren't going to be made today, 24-hours removed from our first glimpse of this vaunted squad.
At risk of being a hypocrite – having already said conclusions can't be made from this game – Gordon confirmed he has the ability to change the course of a season. There's a reason he's been called "auto-correct." As October-looking shots sloppily made their way up and around the rim, Gordon was there, more often than not, to secure the rebound or the basket. While it's been widely noted the kid has a non-stop motor, he has a non-stop motor.
Am I excited about this season? You're damn right I am and the Red-Blue production I streamed did nothing but confirm that excitement.
And at risk of being a further hypocrite, my primary takeaway despite Tarczewski's 18 points is that Sean Miller is going to have a helluva time keeping Rondae Hollis-Jefferson off the floor. Basketball is played by just five players at a time and sometimes it might seem that the lengthy freshman, on paper, could be the odd man out (considering the leash allotted Tarczewski last year).
Now Note: I'm all for giving seven-footers the room they need to dominate. But sometimes, just sometimes, you have better options. That's not to squeeze Kaleb out by any stretch of the imagination, but don't be surprised if crunch time includes the southpaw from Philadelphia.
Because Saturday was more about the celebration of a forthcoming months of college basketball competition and the promise of the further excitement it promises. Competition ensues against colors neither blur nor red. There's a left column to fill up.


The Gal Oya area is resplendent with forest and lush with vegetation. Totally off-the-beaten-track and off-limits during the war, the area has avoided much development and the landscape is mostly unspoiled. Living within the deep forests surrounding the national park are the Veddas – Sri Lanka's dwindling indigenous community, a mostly unheard of tribe who claim that this particular area has an unusually high density of medicinal plants that can cure any disease. This sense of mystery and mystique seems to be intrinsically linked with the landscape. From above one can't see a thing through the thick bowers of the forest, cloaking the area in secrecy. But it is not only a rich range of plant life that you will find in these forests. Thirty-two types of mammals have been recorded in this area, as well as a notably wide variety of birds and reptiles. You are unlikely to see the larger mammals, but you will definitely come across some interesting birds, butterflies and reptiles. Climb to the top of Monkey Mountain for panoramic views of the surrounding forest.
Getting up at the crack of dawn to beat the midday heat, enjoy a quick cup of tea or coffee before you begin the climb with your naturalist. Monkey Mountain lies at the foot of the Gal Oya Lodge property and a swift twenty minute walk brings you straight to the base of the mountain. From there it's an uphill climb, often hand-over-foot, towards the top. You'll walk through forest, climb over giant boulders and hopefully spot some wildlife as you make your way to the mountain peak. It's a tough two hour hike, but the views from the top will ease any aching legs on sight. Jutting out into the surrounding forest, the mountain offers phenomenal views of the Gal Oya area. It's a serenely beautiful spot to spend an hour enjoying the views and the fresh air before you head back down towards the lodge again. Finish up with a well-deserved breakfast back at the lodge.
refreshments, bottled water, accompanying naturalist.
hard – we classify this as hard because there are no steps to go up the mountain so you will very literally be climbing with your hands and feet at some points.
Young children may struggle with the climb, but older children and teens that enjoy being outdoors will love this experience.
Breakfast is normally served once you arrive back at the lodge (at roughly 10am). You will be given some fruit to snack on at the top of the mountain, but if you feel that this is not enough to get you through the climb, please do put in a request to the staff for an early breakfast pack.
This experience is not private, other lodge guests who wish to come may join your group.


"It would be worse than trying to reconstruct a book that youburned from its ashes," says Page. In his paper, Hawking comparesit to trying to forecast the weather ahead of time: in theory it ispossible, but in practice it is too difficult to do with muchaccuracy.
If Hawking is correct, there could even be no singularity at thecore of the black hole. Instead, matter would be only temporarilyheld behind the apparent horizon, which would gradually move inwardowing to the pull of the black hole, but would never quite crunchdown to the centre. Information about this matter would notdestroyed, but would be highly scrambled so that, as it is releasedthrough Hawking radiation, it would be in a vastly different form,making it almost impossible to work out what the swallowed objectsonce were.
Unlike the event horizon, the apparent horizon can eventuallydissolve. Page notes that Hawking is opening the door to a scenarioso extreme "that anything in principle can get out of a blackhole". Although Hawking does not specify in his paper exactly howan apparent horizon would disappear, Page speculates that when ithas shrunk to a certain size, at which the effects of bothquantummechanics and gravity combine, itis plausible that it could vanish. At that point, whatever was oncetrapped within the black hole would be released (although not ingood shape).
Although Page accepts Hawking's proposal that a black hole couldexist without an event horizon, he questions whether that alone isenough to get past the firewallparadox. Thepresence of even an ephemeral apparent horizon, he cautions, couldwell cause the same problems as does an event horizon.
Conversely, in the 1970s, Hawking also showed that black holescan slowly shrink, spewing out 'Hawking radiation'. In that case,the event horizon would, in theory, become smaller than theapparent horizon. Hawking's new suggestion is that the apparenthorizon is the real boundary. "The absence of event horizons meansthat there are no black holes — in the sense of regimes from whichlight can't escape to infinity," Hawking writes.
In place of the event horizon, Hawking invokes an "apparenthorizon", a surface along which light rays attempting to rush awayfrom the black hole's core will be suspended. In generalrelativity, for an unchanging black hole, these two horizons areidentical, because light trying to escape from inside a black holecan reach only as far as the event horizon and will be held there,as though stuck on a treadmill. However, the two horizons can, inprinciple, be distinguished. If more matter gets swallowed by theblack hole, its event horizon will swell and grow larger than theapparent horizon.
Now Hawking proposes athird, tantalizingly simple, option.Quantummechanics and general relativity remain intact, but black holessimply do not have an event horizon to catch fire. The key to hisclaim is thatquantumeffects around the black holecause space-time to fluctuate too wildly for a sharp boundarysurface to exist.
This was alarming because, although the firewall obeyedquantumrules, it flouted Einstein'sgeneral theory of relativity. According to that theory, someone infree fall should perceive the laws of physics as being identicaleverywhere in the Universe — whether they are falling into a blackhole or floating in empty intergalactic space. As far as Einsteinis concerned, the event horizon should be an unremarkableplace.
But on analysing the situation in detail, Polchinski's team cameto the startling realization that the laws ofquantummechanics, which govern particles on small scales, change thesituation completely.Quantumtheory, they said, dictates thatthe event horizon must actually be transformed into a highlyenergeticregion, or 'firewall', thatwould burn the astronaut to a crisp.
In a thought experiment, the researchers asked what would happento an astronaut unlucky enough to fall into a black hole. Eventhorizons are mathematically simple consequences of Einstein'sgeneral theory of relativity that were first pointed out by theGerman astronomer Karl Schwarzschild in a letter he wrote toEinstein in late 1915, less than a month after the publication ofthe theory. In that picture, physicists had long assumed, theastronaut would happily pass through the event horizon, unaware ofhis or her impending doom, before gradually being pulled inwards —stretched out along the way, like spaghetti — and eventuallycrushed at the 'singularity', the black hole's hypotheticalinfinitely dense core.
Hawking's new work isan attempt to solve what is known as the black-hole firewallparadox, which has been vexing physicistsfor almost two years, after it was discovered by theoreticalphysicist Joseph Polchinski of the Kavli Institute and hiscolleagues (see 'Astrophysics: Fire in the hole!').
Hawking posted his paper on the arXiv preprint server on 22January1. He titled it, whimsically, 'Information preservation andweather forecasting for black holes', and it has yet to pass peerreview. The paper was based on a talk he gave via Skype at ameeting at the Kavli Institute for Theoretical Physics in SantaBarbara, California, in August 2013 (watch video of the talk).
In its stead, Hawking's radical proposal is a much more benign"apparent horizon", which only temporarily holds matter and energyprisoner before eventually releasing them, albeit in a more garbledform.
Notion of an 'event horizon', from which nothing can escape, isincompatiblewithquantumtheory,physicist claims.


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Tag Archives: Nazi
Only one thing saddens me as a producer when I look back to the blissfully happy days I spent in the Bailiwick producing my TV documentary 'Channel Islands Occupied'and that is, too late in the day to change the shooting schedules, I happened upon Guernsey's other fantastic German Occupation Museum. Owned by brothers Peter & Paul Balshaw and located down at La Valette in the capital St Peter Port, this superb museum it is sited deep inside some imposing German concrete tunnels carved out of the hillside overlooking the beautiful harbour, with the old open-air swimming pools set in the rocks just below it and the stunning Castle Cornet shimmering away in the distance.
However happily for me, (courtesy of my later work as a consultant for the Guernsey Tourist Board's initiative 'Fortress Guernsey'), I was able to rectify that error just a little by helping to additionally publicise this fabulous museum through both my writing & broadcasting and being able to tour-guide a number of interested journalists & other documentary film-makers around these incredible tunnels and the stunning personal collection of German military & Guernsey civilian artefacts that the two brothers have imaginatively put on public display.
This award-winning museum covers many aspects of the Bailwicks' military past including both the First & Second World Wars and the engaging story of Guernsey's Militia… and all uniquely placed within a series of air-conditioned tunnels originally built by the Germans as a fuel storage facility for U-Boots visiting the Bailiwick during the years of 1940 to 1945..
The Third Reich had a 'real thing' about tunnelling and in the Channel Islands this task was given over to the para-military Organisation Todt, (effectively the Nazi's fortifications building company staffed by highly-qualified German technicians), where, using 'Forced Labour' taken from the occupied territories to work in these beautiful islands, they had something of a field-day with 41 such tunnels being started in Guernsey alone..!
However across the islands as a whole it is the German Underground Hospital in Jersey, (now referred to somewhat less enigmatically as 'Jersey War Tunnels'), that is probably the most well known of these subterranean structures, though that was originally built as an ammunition tunnel and only became an active military hospital after the Allied invasion of Normandy on June 6th 1944. At this point many German troops wounded in the fighting in France were evacuated to Jersey for treatment in these newly-converted tunnels… though spending many weeks underground cannot have been a totally welcome proposition for those badly knocked about Wehrmacht & Waffen-SS soldiers!
However Guernsey's tunnels at La Valette are typical of the O.T. engineering that was undertaken across the Channel Islands during the occupation and were initially conceived as an underground dump from which, (protected from RAF attack above), fuel would then be pumped down to the Kriegsmarine's submarines at their moorings in the bay below. However this particular tunnel complex was never completed as the necessary building supplies from France were cut off shortly after D-Day, though the Germans did try hard to get it finished using what meagre supplies they still had to hand…
Meanwhile the OT architects designed the tunnel bays in such a way that if any of the tanks were ruptured or sprang a leak, (accidentally or through sabotage), all of the fuel could be securely contained in a protective pool beneath each tank and then be allowed to safely drain away through the specific ducts which were installed. At this point it's worth noting that when the tunnel was eventually converted into the modern museum it is now, the local Guernsey Fire Brigade had to pump some 1,500 gallons of water in a constant stream through one of the drains… which handled it just as originally designed!
Just two years after war's end, today's underground museum was just a nebulous idea for many years hence… but that day eventually came in 1986 when, after a feasibility study showed it was financially possible, discussions opened with the States of Guernsey's Board of Administration and then States' Engineers looked into the tunnel's structural safety. Finally, after a year of too-ing & fro-ing between various island governmental departments, the go-ahead was given and work on the tunnel's conversion started in December of the following year
Beginning with an excavation of two tunnel entrances, (one to provide a main entrance and the second to provide an emergency exit), an extension to the existing tunnel lining was then added as protection from falling debris from the cliff above, steps & vehicle ramps were built and a connecting tunnel between the fuel tank bays was completed so future visitors could see an unfinished tunnel in complete safety.
Meanwhile local 'subbies' re-wired the tunnels, installed air-conditioning, fitted smoke detectors, emergency lights, security & fire alarms and also spray-painted the whole interior; plus the one remaining fuel tank had to be pumped clean of its remaining 500 gallons of fuel and refilled with water as a bulwark against any explosive gases building up over time…
Unfortunately for the budget, the existing supports underneath the tank were found to be unsafe and so new block-work walls had to be constructed then, to prevent further rusting, the tank had to be de-scaled and sprayed with a rust-preventative primer… only then could museum glass cabinets be constructed & wired-in and myriad tailor's dummies dressed and displayed.
Signs explaining the tunnel's original usage were also produced, missing uniform items sourced & displayed and restoration of other occupation exhibits undertaken… but finally the whole wonderful collection reached 'museum standard' and ready for public presentation and so, in the Summer of 1988, the doors were thrown open to the island's enthusiastic visitors.
When I finally discovered this exciting museum for myself, my jaw figuratively hit the floor as I took in Peter & Pauls' amazing handiwork and the realisation that this fabulous scene should really have been featured in my documentary. I certainly experienced a real tingling sensation as I stepped down into these huge concrete tunnels as originally designed by the island's German occupiers and built by imported forced labourers in conditions of such hardship..!
The fact that this ultra-professional display of living history was underground really added to the surreal film-set atmosphere and gives everything a great deal more poignancy & focus than might otherwise have been the case. Now walking through these enormous tunnels today with echoes of the same military music from our Tomahawk Films Archive that Guernsey's German occupiers would also have heard over 70 years ago, all adds to that slightly eerie feeling of having taken a step back in time..!
It was quite a feat of German engineering to create this U-Boot & Luftwaffe refuelling tunnel in the early 1940s, but I think that is nothing compared to the marvel of design & reconstruction that went into the La Valette Hohlgang by Peter & Paul Balshaw and their builders… as such this underground military museum is nothing short of superb and must be included on your Guernsey visitor itinerary… you'll certainly kick yourself if you don't!!
Posted in Archive, News	| Tagged Adolf Hitler, Blitzkrieg, Brian Matthews, Castle Cornet, Channel islands Occupied, D-Day, Deutschlandlied, Erika, Festung Guernsey, German Military Music, German Soldier Song, German Underground Tunnel, Guernsey, Hohlgang, Jersey War Tunnels, June 6th 1944, Kanal Iseln, Kriegsmarine, La Valette Museum, Leibstandarte-SS, Lili Marleen, Musik in der Heimat, Nazi, Nazi Concentration Camp, Nazi-era Music, Organisation Todt, Panzer Lied, Peter & Paul Balshaw, Schellack 78rpm records, Slave Labour, SS-Alte Kameraden, Third Reich, Third Reich Music, Tomahawk Films, U-boot, Waffen-SS Soldier Songs, Wehrmacht, Wunschkonzert fuer die Wehrmacht


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Motions To Quash Subpoenas
We file motions to quash subpoenas that have been improperly served. In many of our cases, we are fighting for the rights of persons who were engaging in their right to speak anonymously on the internet. We also fight to quash government subpoenas that are overbroad or otherwise unlawful, in order to preserve the anonymity of our clients.
Submit your case online
We can help with your motion to quash.
If you want to discover the identity of someone who posts to a website anonymously or emails to others anonymously, court subpoenas are often the most effective tools for obtaining this information. However, courts must balance, on the one hand, the rights of companies who have been defamed or otherwise injured, and, on the other hand, the First Amendment and other rights of people posting or emailing over the internet anonymously.
Litigating internet speech cases has been a significant part of our practice for over 10 years.
When a subpoena is issued in an attempt to identify an anonymous internet actor, the anonymous party can file a Motion to Quash a Subpoena, relying upon the First Amendment and other constitutional and statutory grounds. The anonymous party may also file his or her Motion to Quash anonymously, and if the Motion to Quash is granted, the anonymous party remains anonymous.
Kronenberger Rosenfeld has handled countless subpoenas in this area of anonymous internet activity. If a service provider has informed you that it has received a subpoena and will disclose your identity unless you file a motion to quash the subpoena, contact us today at (415) 955-1155, ext. 120, or submit your matter using our online case submission form.
REPRESENTATIVE EXPERIENCE
Represented John Doe in a motion to quash subpoena seeking information about the owner of a Twitter account.
Represented a client in an appeal of a motion to quash a subpoena issued pursuant to the federal foreign discovery statute (28 U.S.C. §1782).
Advised an anonymous blogger who successfully quashed a subpoena seeking his/her identity, issued by a reality TV personality unhappy about negative blog postings.
Need to file a Motion to Quash a Subpoena?
We welcome you to submit your details using our online case submission form
by giving us a call at
ext. 120 for new legal matters
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We have been overwhelmed with demand and unfortunately cannot accept more patients at the moment. Please join our waitlist to hear when we have more supply!
We will connect you with a pharmacy that can produce a compounded formulation of bosentan to meet your specific clinical needs. We do not have available at this time though have supplies arriving soon.


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  <groupId>com.twitter</groupId>
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  <packaging>jar</packaging>
  <version>6.1.1-SNAPSHOT</version>
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    <version>0.0.4</version>
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  <dependencies>
    <!-- library dependencies -->
    <dependency>
      <groupId>com.twitter.common</groupId>
      <artifactId>flags</artifactId>
      <version>1.0.0</version>
      <!-- excluded to prevent conflicts with caged finagle/util -->
      <exclusions>
        <exclusion>
          <groupId>com.google.guava</groupId>
          <artifactId>guava</artifactId>
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        <exclusion>
          <groupId>com.twitter</groupId>
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        <exclusion>
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        </exclusion>
        <exclusion>
          <groupId>com.twitter</groupId>
          <artifactId>finagle-thrift</artifactId>
        </exclusion>
      </exclusions>
    </dependency>
    <dependency>
      <groupId>org.slf4j</groupId>
      <artifactId>slf4j-nop</artifactId>
      <version>1.6.1</version>
      <scope>provided</scope>
    </dependency>
    <!-- project dependencies -->
    <dependency>
      <groupId>com.twitter</groupId>
      <artifactId>finagle-core</artifactId>
      <version>6.1.1-SNAPSHOT</version>
    </dependency>
    <dependency>
      <groupId>com.twitter</groupId>
      <artifactId>finagle-http</artifactId>
      <version>6.1.1-SNAPSHOT</version>
    </dependency>
    <dependency>
      <groupId>com.twitter</groupId>
      <artifactId>finagle-kestrel</artifactId>
      <version>6.1.1-SNAPSHOT</version>
    </dependency>
    <dependency>
      <groupId>com.twitter</groupId>
      <artifactId>finagle-memcached</artifactId>
      <version>6.1.1-SNAPSHOT</version>
    </dependency>
    <dependency>
      <groupId>com.twitter</groupId>
      <artifactId>finagle-ostrich4</artifactId>
      <version>6.1.1-SNAPSHOT</version>
    </dependency>
    <dependency>
      <groupId>com.twitter</groupId>
      <artifactId>finagle-redis</artifactId>
      <version>6.1.1-SNAPSHOT</version>
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        <artifactId>maven-finagle-thrift-plugin</artifactId>
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            <thriftGenerator>scrooge</thriftGenerator>
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redpajama_set_name: RedPajamaGithub


Ahead of International Women's Day (8 March), the European Commission is reaffirming its commitment to tackle gender inequalities across the EU. According to new Eurobarometer statistics published today, a large majority of citizens (76%) believe that tackling inequality between women and men should be a priority for the EU. According to the latest Eurostat data, the gender pay gap remains stagnant for another year running - per hour women earn 16.4% less than men. The Commission's annual Report on equality between women and men, also published today, shows that despite some progress gender equality remains an unfinished business.
"Europe cannot afford to underuse the potential of 50 percent of its population. Even though equal chances for women and men are more than ever becoming a reality, there is still a long way to go. For every euro a man earns in Europe, a woman still earns only 84 cents. Women are still underrepresented in leadership both in business and in politics. And worst of all, one in three women has experienced physical and sexual violence. This is unacceptable. I am committed to addressing these challenges and to achieve tangible results." said Vĕra Jourová, EU Commissioner for Justice, Consumers and Gender Equality.
Around nine in ten Europeans (91%) agree that tackling inequality between men and women is necessary to establish a fairer society. A similar proportion (89%) agree that equality between men and women will help women become more economically independent.
Violence against women (especially sexual violence), and the gender pay gap are the two areas that the EU should address most urgently, according to 59% and 53% of Europeans respectively.
For every hour worked women earn on average 16.4% less than men. This figure is above 20% in Czech Republic, Austria, Estonia and Germany. Closing the gender pay and pension gap has been frustratingly slow. The latter has reached 39 %. Women still tend to be concentrated in less well-paid sectors.
Gender gaps in employment and decision-making have narrowed in recent years, but women still account for less than a quarter of company board members, despite representing almost half of the employed workforce (46 %). Also, the extent of gender equality varies substantially across Member States and has not reached all groups. Deficient work-life balance policies hamper women's employment and therefore the potential for economic growth.
Women are more likely to have a higher education degree (over 60% of new graduates are female), but are significantly under-represented in STEM studies and careers, in research and in senior posts at all levels of education, including higher education.
The EU has supported specific actions, such as national governments' campaigns against gender-based violence and grass-root projects led by non‑governmental organisations. (See 2014 Report on equality between women and men, chapter and adopted legislation and practical measures on victims' rights (see MEMO/15/4465 and IP/15/3045) to protect women and girls from gender-based violence.
All male members of the European Commission have given their support to the UN campaign #HeforShe aiming to make gender equality an issue for both men and women. This reflects the Commission's strong support for women's rights and women's empowerment. The #HeforShe campaign by UN Women calls for the more active engagement of men in the fight against such discrimination, since they play a pivotal role in changing the social norms that affect women.
The Commission is also celebrating outstanding women entrepreneurs who have brought their innovative ideas to the market. On Monday 9 March, Carlos Moedas, Commissioner for Research, Science and Innovation, will launch the 3rd edition of the EU Prize for Women Innovators to give public recognition to three remarkable women and inspire others to follow in their footsteps.
The Commission will continue its work with Member States, NGOs and stakeholders to drive forward gender equality at all levels, strengthening and consolidating the gains made in the past and meet the new challenges in the period ahead. The focus will be on "finishing the unfinished business" to close the gaps in pay, employment, pensions and decision-making, and to eradicate gender-based violence.
The Latvian Presidency will table Council conclusions on the gender pension gap that will contribute to shaping a policy response to this issue. Legislative proposals such as the Women on Boards Directive or the Maternity Leave Directive must now be agreed in the Council by Ministers from the Member States as well as by the European Parliament in order to become law. Member States will also notify measures taken to improve pay transparency. This follows the Commission's Recommendation on Equal Pay Transparency giving Member States, for the first time, a toolbox of measures to tackle this issue.
Science, technology, engineering and mathematics. The two broader fields of study grouped here are "science, mathematics and computing" and "engineering, manufacturing and construction".


text:
class Camera;
struct GLFWwindow;

class Input
{
    GLFWwindow* m_glwindow;

    static bool m_rightMouseDown, m_leftMouseDown;
    static double m_scrollOffset, m_relScroll, m_cursorX, m_cursorY, m_relCursorX, m_relCursorY;

    static void key_callback(GLFWwindow* window, int key, int scancode, int action, int mods);
    static void mouse_button_callback(GLFWwindow* window, int button, int action, int mods);
    static void scroll_callback(GLFWwindow* window, double xoffset, double yoffset);
    static void cursor_position_callback(GLFWwindow* window, double xpos, double ypos);
public:
    Input(GLFWwindow* window);
    void poll();
    void poll(Camera& cam);
    static bool rightMouseDown();
    static bool leftMouseDown();
    static double scrollOffset();
    static double relScroll();
    static double cursorX();
    static double cursorY();
    static double relCursorX();
    static double relCursorY();
    bool getKey(int key);
    const int* begin();
    const int* end();
    static const int* downBegin();
    static const int* downEnd();
    static const int* upBegin();
    static const int* upEnd();
};
#endif


text:
Q: Google login with flutter aad_oauth does not work because of webview I am doing an azure active directory login with this plugin https://pub.dev/packages/aad_oauth.
However the plugin uses the webview plugin and the following error occurs because of that.
"You can't sign in from this screen because this app doesn't comply with Google's secure browser policy"
Error 403 dissallowed_useragent

How do I get around this problem?

A: Google allows sign-in with Google Account only in normal browsers, it restricts it in web-views due to security reasons and recommends Google SDKs for iOS and Android for this purpose.
A similar behaviour exists for Facebook login.
In general, these services recognize the default WebView user agent, so to make it work, you could just set a custom user agent value.
You can use my flutter_inappwebview plugin to implement this logic.
I have created a project example that implements it and it's available at https://github.com/pichillilorenzo/flutter_inappwebview_examples/tree/main/third_party_oauth_user_sign_in


Although women are particular using the cost of the clothes, you'll find that plenty of them would still invest on designer or branded clothes. On their behalf, these designer clothes can define their style in a next stage due to the name making them feel at ease than your regular clothes. The good thing is these branded clothing is already obtainable in designer wholesale so women could possibly get their branded clothes in the best cost the want.
There are lots of branded women's wholesale fashion clothing based in the market today. This provides women several options when it comes to their preferred name as well as their style. Types of these clothing is individuals originating from these popular brands.
This brand is among the known brands on the market that provide women fashionable clothes ideal for corporate clothing needs. Nowadays, you will find increasingly more empowered and career ladies wouldn't only dominate the field of marketing and companies but additionally to become in their best when it comes to fashion. Zara designs lots of beautiful tops and different slacks which will match the design and style preference of each and every lady. What this means is they'll obtain the clothes on their behalf whether or not they like slacks or skirts. With a set of good and trendy footwear or stilettos, they'll get the best style appropriate on their behalf especially with regards to comfort.
The very first factor which will enter into the mind upon hearing this name is casual and concrete clothing. Because there are also a lot of women who enjoy having casual clothing, Abercrombie and Fitch offer stylish clothes appropriate for women's frame. They've jackets, jeans, and tops that can make women look fashionable even if they're putting on casual clothing originating from this brand. If you're one of many individuals who love this brand, you will find plenty of firms that already offer this kind of clothing so you will get them in the best cost the marketplace is providing.
Should there be rap or formal women, there's also individuals who love sports and would also enjoy having an activity designer wholesale clothes. Adidas is a popular brand with regards to different sporty apparel. The great factor about these clothes is the fact that you will get exactly the same quality in a cost as these companies offer authentic sporty clothes. If you wish to get tops that may wick sweat and stays awesome even though you sweat, you will find them only at that brand. This stuff will also be essential in holding you back comfortable in whatever sports you need to do or simply exercising during a workout session. Apart from sporty clothes, you'll notice that additionally they offer regular clothing like shirts that they'll use when they're not going to yet start their workshop.


In case you didn't notice we just added a bunch of basic syndicated video features to Netscape (a la YouTube).
… here is what happens after you click watch video… the player opens up without a page refresh!
… and of course you can take videos from Netscape and syndicate thm to your own blog. Upload tools are not opn to the public yet, but will be shortly.
Next Post Great white shark… riding?


A crashing app points out the problems of using functions that return values of 'Any' type. Here's one solution.
Domenicus van Wijnen's paintings are radically original, quite unlike other works before him, and not matched for more than a century after. Why don't we know him and these paintings better?
Now adds your own output styles to custom predicates, so that you only view the log information that you want.
An unusual story of sorcery used to restore youth has seldom been painted – even after Mary Shelley's Frankenstein became popular.
Design your own predicate filters, and apply them almost instantly: a significant new feature in this first test release.


A shorter than normal ride, with Captain riding the 'Iron Horse' - so not overly quick. With overnight temperatures set to be around zero I am moving the start time to 11am. 27 miles out and another 8 back to the Coach & Horses for around 3pm where this ride will finish. Lunch at the Golden Cross Hotel, Bromsgrove........OK it's a Wetherspoons really!


text:
/**
 * Pie Module
 * ----------
 * Draw a pie into the scope svg with the scope data.
 *
 */
var p_pie = PClass.extend({

  deps: [
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  _subscriptions: [{
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  initialize: function() {
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    var dataSum = d3.sum(this.data, function(d) {
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      this.opts.onNoData && this.opts.onNoData();
    } else {
      // Pie layout
      this.pie = d3.layout.pie()
        .value(function(d) {
          return d.value >= 0 ? d.value : 0;
        })
        .sort(null);

      // Pie arc
      this.arc = d3.svg.arc()
        .innerRadius(this.opts.radius * this.opts.innerRadius)
        .outerRadius(this.opts.radius);

      // Paths
      this.path = this.$svg.selectAll('path');
      this.update();

      // Set events
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    return {
      series: {
        update: _.bind(this.update, this)
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        path: this.path,
        arc: this.arc
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      dataAvailable: this._dataAvailable
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  /**
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      .each(function(d, i) {
        this._current = d; // store the initial values
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      .attr('class', 'pie-piece');

    this.path.attr('fill', function(d) {return d.data.color;});
    this.path.exit().remove();

    var n = 0;
    this.path.transition()
      .duration(300)
      .attrTween('d', arcTween)
      .each(function() {++n;})
      .each('end', function() {
        if (!--n) { // when the transitions end
          self.trigger('Pie/updated', []);
        }
      });

    function arcTween(d) {
      var i = d3.interpolate(this._current, d);
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      return function(t) {
        return self.arc(i(t));
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  },

  /**
   * Set pie events.
   */
  _setEvents: function() {
    var self = this;

    this.path.on('mouseover', function(d) {
      self.path.exit();
      self.path.style('opacity', self.opts.hoverFade);
      d3.select(this).style('opacity', 1);
      self.trigger('Pie-piece/mouseover', [d]);
    });

    this.$svg.on('mouseleave', function() {
      self.path.style('opacity', 1);
    });
  }

});