text:
Here Are This Year's Winners of the Black Pencil, One of Advertising's Most Coveted Awards – Adweek
By Last updated Jul 12, 2019 11 0
LONDON—Wieden + Kennedy Portland and Droga5 continue to dominate the 2019 awards circuit, today sharing top honors at the D&AD Awards alongside four other marketers.
The U.S. agencies each won a Black Pencil, D&AD's highest award—generally considered one of the most difficult advertising accolades to win.
Droga5's The Truth Is Worth It campaign for The New York Times was one of the London-based festival's biggest winners, taking home two Black Pencils—one for Droga5 as creative agency and one for production house Furlined. The campaign also won seven Yellow Pencils (gold), four Graphite Pencils (silver) and three Wood Pencils (bronze).
Wieden + Kennedy again won for its Nike Dream Crazy campaign, whose launch featured polarizing quarterback Colin Kaepernick. Earlier this month, that work won 10 golds at The One Show, where W+K Portland was also named Agency of the Year. At D&AD, the campaign also won three Yellow Pencils, one Graphite Pencil and one Wood Pencil.
Other Black Pencil winners included:
• London-based AMV BBDO's "Viva La Vulva" film for feminine care company Essity (sold globally under various brand names such as Bodyform or Libresse).
• Australia's BWM Dentsu for its "Project Revoice" campaign with The ALS Association.
• Microsoft's Xbox Adaptive Controller, an accessibility project designed to meet the needs of gamers with limited mobility.
In the 57-year history of D&AD, the festival had only awarded 154 Black Pencils before this year's awards, making it one of the rarest and most hard-fought honors in the marketing world, said D&AD CEO Tim Lindsay.
Some years, no Black Pencils have been awarded. This year's total of six top awards is one of the highest in the festival's history, with the record standing at seven in one year.
"The work I have seen has been fantastic and everyone on the jury and everyone who has seen the final list of Pencil-winning work has been knocked out by the quality," Lindsay said. "It is a hugely encouraging sign for the buoyant and vibrant direction of our industry."
In terms of film, one clear favorite among jurors this year was AMV BBDO's "Viva La Vulva," directed by Kim Gehrig for the Essity family of brands as a follow-up to the highly admired #BloodNormal campaign that sought to shatter the stigmas around periods. The new spot, created to promote the company's new line of new daily intimate care products such as washes and wipes, features an array of visual metaphors for women's vulvas and a stirring anthem in 1975's "Take Yo' Praise" from Camille Yarbrough.
"We thought, if we're going to enter this category, we have to break down taboos, but we have to also break down the shame that goes around using these products," Martina Poulopati, global brand communications manager for Essity, tells Adweek. "You should be fine with taking care of your vulva. You should love it and you should care for it, and you should just feel happy about it. You should celebrate it."
"It's brilliantly crafted," Lindsay said of the spot, "as well as being a joyful idea."
In addition to its Black Pencil, "Viva La Vulva" won four Yellow Pencils, two Graphite Pencils and two Wood Pencils for AMV BBDO and production partner Somesuch.
Here's a look back at the other two Black Pencil winners, Project Revoice for The ALS Association and the Microsoft Xbox Adaptive Controller:
Other big winners at D&AD this year included:
• Droga5, named Agency of the Year, largely based on the success of its New York Times work. Second place went to London's adam&eveDDB (whose 84 Project for suicide awareness and "The Boy and the Piano" for John Lewis & Partners were both highly awarded), and McCann New York (honored for its Universal Love project with MGM Grand Resorts, partnerships with March for Our Lives and National Geographic's Astronaut Reality Helmets).
• Jones Knowles Ritchie, named Design Agency of the Year.
• Academy Films, named Production Company of the Year.
• Apple, named Client of the Year.
• Artist and stage designer Es Devlin, recipient of the President's Award for creative excellence.
The United States led the world in Pencils won, with 223. Britain came in second with 158 Pencils, while Germany was third with 40.
Author - David Griner
Adweek is the leading source of news for marketing, media, and advertising professionals.
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text:
Q: What will be best method to store this type of data in mongoDb? I have to store this type of data in mongodb , for particular user there will be n number of customers whose details have to store. What will be best strategy to store. should I create collection for each user and store customer details in that collection. Suggest method to store and easy retreival.
{
  "user1": {
    "customer1": {
      "name": "name of customer",
      "ageGroup": "20-30",
      "localtion": "customer location",
      "email": "customer@gmail.com",
      "contact": "91991199199",
      "country": "anywhere"
    },
    "customer2": {
      "name": "name of customer",
      "ageGroup": "20-30",
      "localtion": "customer location",
      "email": "customer@gmail.com",
      "contact": "91991199199",
      "country": "anywhere"
    },
     "customer3": {
      "name": "name of customer",
      "ageGroup": "20-30",
      "localtion": "customer location",
      "email": "customer@gmail.com",
      "contact": "91991199199",
      "country": "anywhere"
    }
  },
   "user2": {
    "customer1": {
      "name": "name of customer",
      "ageGroup": "20-30",
      "localtion": "customer location",
      "email": "customer@gmail.com",
      "contact": "91991199199",
      "country": "anywhere"
    },
    "customer2": {
      "name": "name of customer",
      "ageGroup": "20-30",
      "localtion": "customer location",
      "email": "customer@gmail.com",
      "contact": "91991199199",
      "country": "anywhere"
    },
     "customer3": {
      "name": "name of customer",
      "ageGroup": "20-30",
      "localtion": "customer location",
      "email": "customer@gmail.com",
      "contact": "91991199199",
      "country": "anywhere"
    }
  },
  "user3": {
    "customer1": {
      "name": "name of customer",
      "ageGroup": "20-30",
      "localtion": "customer location",
      "email": "customer@gmail.com",
      "contact": "91991199199",
      "country": "anywhere"
    },
    "customer2": {
      "name": "name of customer",
      "ageGroup": "20-30",
      "localtion": "customer location",
      "email": "customer@gmail.com",
      "contact": "91991199199",
      "country": "anywhere"
    },
     "customer3": {
      "name": "name of customer",
      "ageGroup": "20-30",
      "localtion": "customer location",
      "email": "customer@gmail.com",
      "contact": "91991199199",
      "country": "anywhere"
    }
  }
}

A: I would suggest using the Attribute pattern as you have many similar fields within your objects.
The structure could look like:
{
  "user1": {
    "customers": [
      {
        "id": "customer1",
        "name": "name of customer",
        "ageGroup": "20-30",
        "localtion": "customer location",
        "email": "customer@gmail.com",
        "contact": "91991199199",
        "country": "anywhere"
      },
      {
        "id": "customer2",
        "name": "name of customer",
        "ageGroup": "20-30",
        "localtion": "customer location",
        "email": "customer@gmail.com",
        "contact": "91991199199",
        "country": "anywhere"
      }
    ]
  },
  "user2": {
    "customers": [
      {
        "id": "customer1",
        "name": "name of customer",
        "ageGroup": "20-30",
        "localtion": "customer location",
        "email": "customer@gmail.com",
        "contact": "91991199199",
        "country": "anywhere"
      },
      {
        "id": "customer2",
        "name": "name of customer",
        "ageGroup": "20-30",
        "localtion": "customer location",
        "email": "customer@gmail.com",
        "contact": "91991199199",
        "country": "anywhere"
      }
    ]
  }
}

This would allow you to create fewer search indexes for the array of objects like:
{ "customers.id": 1, "customers.email": 1}

redpajama_set_name: RedPajamaStackExchange


Listen to your favorite radio stations including NYC's Z100, Howard Stern, ESPN, Opie and Anthony, Alex Jones Infowars, idobi radio, 181.FM, and many more.
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Lists more local stations than other radio apps that I have tried and the ads are not intrusive.
I have this app on my phone and now my desktop. Work good. Stops periodically and you have to restart the app. I would recommend this app to anyone. The "10 codes" are not accurate, (very different from what our department uses), for my area but I have my own copy of the codes my police department uses.
Review title of larryWOULD NOT TRADE IT FOR ANYTHING.
A GREAT WAY TO HEAR POLICE & FIRE.
I don't like the fact that Its offline! I haven't been able to hear it for about a week now!!!!
Review title of DavidThe little app that could.


text:
HomeTechnologyComputingWhat do the Short-Term Technicals Predict for Substratum (SUB) Sunday?
TechnologyComputing
What do the Short-Term Technicals Predict for Substratum (SUB) Sunday?
By Dewey Hardin
News at home
Sunday, November 20, 2022 2:06 PM | InvestorsObserver Analysts
Investors Observer gives Substratum a weak technical short term score of 6 from the analysis. The proprietary scoring system takes into account the token's trading history over the past month to determine the strength of its near-term technical characteristics. SUB has currently traded over 6% of tokens based on these metrics. Investors focusing on sound recent trading patterns should find the short-term technical classification system more relevant when making investment decisions.
Investors Observer gives Substratum a 6 Short-Term Technical Rank. Find out what this means for you and get the rest of the rankings on Substratum!
Trade analysis
Substratum is $0.000133 (45.28%) higher than the 30-day low of $0.000293049, while also -$0.000443 (-50.97%) lower than the $0 high .00086833 of the last trading month. Meanwhile, SUB's current price of $0.000425728 is below the $0.000769422 average price of the past trading month, leading to a weak short-term technical score. In summary, Substratum's recent trading history suggests that traders are currently bearish on the token. SUB has a relatively low market cap for a token with a total market value of $163,062.75. Substratum's relatively low market value is due to it being below $100 million, while the top 100 cryptos remain above $1 billion in market cap and the top 500 are above $100 million. Substratum's average volume, meanwhile, is low with $751.13 worth of the token traded over a typical 24-hour period. SUB's volume is relatively low as the most traded 100 cryptos typically trade $100 million per day and smaller cryptos tend to trade less than $5 million over 24 hours. As of the last 24 hours, SUB's volume is below average with $120.24 redeemed. Substratum's Distributed Computing subclass: While all blockchain technology is a form of distributed computing, projects in this category typically provide access to a range of distributed computing resources.
Garmin's November watch update adds a ton of features: Here's what's included
SUB's recent trading over the past month gave it a weak short-term technical score as the recent price move gives traders reason to be more bearish on the token in the short term.
Click here for the full report on substrate (SUB).
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redpajama_set_name: RedPajamaCommonCrawl


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Playtech offers an excellent choice of the most played and top rated online slot games, allowing each player to choose a slot game of their choice. Innovative and unique slot machines created by this software company can be played in over 30 various languages using different currencies. All slot games can be played instantly in flash from the browser or as a part of downloadable software, providing players with a freedom of choice. Video slots created by this software company feature unique themes and offer a large number of paylines, advanced 3D graphics and various bonus features. Brand games like Gladiator, Pink Panther and the Marvel Movie slot games are widely admired by the slot fans all over the world.
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Playtech features a great variety of progressive jackpot games. These games are not only so much fun to play, but also allow the players to score huge wins. In particular, a unique 5 reel 20 payline progressive video slot game Beach Life awards jackpots which can go into the millions. The largest jackpot of this game known up to date exceeds over 4.5 million USD, while the smallest jackpot starts at 50 000 USD. Another exciting line of progressive jackpots is represented by the Marvel Movie slots. In particular, all Marvel Movie slots developed by this software company feature a multi- level, progressive Marvel Mystery Jackpot, which offers additional fun and excitement to the players. Marvel Mystery Jackpot is triggered at random, thus a winning combination is not required and this jackpot can start after absolutely any spin. Also, once the Marvel Mystery Jackpot begins, players can expect to win at least one jackpot for sure, which is quite exciting and satisfying for each player.
Playtech is a leading developer of the live gaming software and is quite famous for developing the Live platform, an excellent live solution for the online casinos with live casino tables and live Asian or European dealers. Playtech Live allows each player to experience a wide range of classic games, such as Roulette, Blackjack, Baccarat and many others. Playtech Live offers live professional dealers which can appeal to various audiences around the globe and allow each player to experience the first class casino experience within the comfort of their own home. Live Gaming offers an exclusive audio-visual experience to the players, with excellent music, sounds and real time statistics using the high quality 3D video streaming.


text:
Nearly 300,000 Dead in India so far From GMO Crop Failures
by ETHAN A. HUFF
The Western media is steeped in denial about the true damage being caused by genetically modified (GM) crops, especially in the developing Third World. But despite the lies you may have heard from mainstream news sources, nearly 300,000 Indian farmers have committed suicide since 1995 as a direct result of mounting debt and crop failures associated with GMO crops, and mainly cotton crops that were forcibly converted to patented, transgenic varieties owned by Big Biotech.
A report by India's National Crime Records Bureau (NCRB) revealed that, between 1995 and 2011, 290,740 farmer suicides had taken place due to economic failure, poverty and bankruptcy caused by GMO adoption. And in the years since that time, for which there is no official data, there have more than likely been thousands of additional suicides, bringing this number to at least 300,000 and possibly higher.
As explained in a thorough report by philosopher, physicist and environmental activist Dr. Vandana Shiva, GMO crop technologies are a Trojan Horse that multinational corporations are using to seize control of the global food supply. With false promises of increased yields and lower costs, corporations like Monsanto have swooped in and locked Indian farmers into contractual agreements that make them dependent on a centralized agriculture system that, in many cases, ends up bankrupting them.
Before Monsanto came along and changed everything, thanks to the 1988 Seed Policy imposed by the World Bank, Indian farmers grew heritage cotton amidst a variety of other crops, which effectively guarded them against invasive species and insect pests. Since the seeds of these crops were natural, farmers could save them year after year and replant them without having to pay royalties for new seeds.
The system wasn't perfect, of course. But it did allow Indian farmers the freedom to control their own agricultural destinies and didn't plunge them into excessive debt, which is what many of them now face as a result of Monsanto's GMOs. According to Dr. Shiva's extensive research, the new system has essentially created slaves out of India's farmers, who are now locked into contractual agreements with Big Biotech, with no way of escape.
"Through patents on seed, Monsanto has become the 'Life Lord' of our planet, collecting rents for life's renewal from farmers, the original breeders," wrote Dr. Shiva for Global Research.
"These are seeds of deception — the deception that Monsanto is the creator of seeds and life; the deception that while Monsanto sues farmers and traps them in debt, it pretends to be working for farmers' welfare, and the deception that GMOs feed the world. GMOs are failing to control pests and weeds, and have instead led to the emergence of superpests and superweeds."
Monsanto illegally seized control of 95 percent of India's cotton seeds, with no consequences
Dr. Shiva documents the entry of Monsanto into India beginning in the late 1980s, citing its incremental takeover of the nation's agricultural system. It all began when India deregulated its seed sector, which led to the gradual concentration of the seed sector. Monsanto proceeded to buy up all the seed companies it could get its hands on, creating joint ventures and licensing agreements with those that remained.
In time, the common pool of seeds available to Indian farmers came to be comprised almost solely of patented Monsanto seeds, which were branded and marketed as miracle seeds that would make farmers rich and supply food for everyone. Once adopted, however, these "terminator" seeds turned out to have the opposite effect — hundreds of thousands of Indian farmers ended up losing their crops, their bank accounts, their livelihoods and in many cases their lives, as a result of taking the GMO bait.
"[S]eed which had been the farmers' common resource became the 'intellectual property' of Monsanto, for which it started collecting royalties, thus raising the costs of seed," explained Dr. Shiva. "[O]pen pollinated cotton seeds were displaced by hybrids, including GMO hybrids. … [C]otton which had earlier been grown as a mixture with food crops now had to be grown as a monoculture, with higher vulnerability to pests, disease, drought and crop failure."
Now, Monsanto owns a whopping 95 percent of India's cotton seeds, which by any accepted definitions of the word is a near-total monopoly. It was only able to achieve this, of course, through deception and illegal activity, including open-air field trials that it conducted back in the late 1990s and which had never been approved by India's government. Monsanto continued these trials anyway, despite their illegality, and eventually took control of the entire industry.
"Monsanto's seed monopolies, the destruction of alternatives, the collection of superprofits in the form of royalties, and the increasing vulnerability of monocultures has created a context for debt, suicides and agrarian distress which is driving the farmers' suicide epidemic in India," Dr. Shiva conclusively stated.
http://articles.economictimes.indiatimes.com
http://www.theguardian.com
http://www.globalresearch.ca
http://www.projectcensored.org
http://science.naturalnews.com
Credit: Natural News
Image:Flickr/mehajain13/India Fieldwork
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Work is progressing on operation Lawn Be Gone. With the assistance of chickens, of course. Earlier this week, I had 5 cubic yards of compost delivered, and I'm gradually prepping planting beds. The soil is even finer, denser clay than that in Albuquerque. I didn't know that was even possible. The soil has been so wet, I haven't been working it other than removing the grass. However, we finally had a few sunny days in a row, so yesterday I was able to work some of the compost in (right now it's mostly serving as mulch) and get my first few edible plants in the ground. I transplanted a small patch of greens: and most of the herb garden: There's a lot more to go, but today I'm going to take a break from digging to work on getting some temporary fencing in place to protect the vegetables from the chicken scratching and ravenous bunnies.


text:
363:711–723.
Pembrolizumab PD-1 Melanoma, NSCLC, HNSCC, cHL (2014) [2] Hamid O, Robert C, Daud A et al. (2013) N Engl J Med 369:134–144.
Nivolumab PD-1 Melanoma, NSCLC, RCC, cHL, SCCHN, UC, dMMR solid cancers, CRC, HCC (2014) [3] Weber JS, D'Angelo SP, Minor D et al. (2015) Lancet Oncol 16:375–384.
Atezolizumab PD-L1 Bladder, NSCLC (2016) [4] Rosenberg JE, Hoffman-Censits J, Powles T et al. (2016) Lancet 387:1909–1920.
Avelumab PD-L1 MCC, bladder (2017) [5] Kaufman HL, Russell, J, Hamid O et al. (2016) Lancet Oncol 17:1374–1385.
Durvalumab PD-L1 Bladder (2017) [6] Antonia SJ, Vilegas A, Daniel D et al. (2017) N Engl J Med 377:1919–1929.
Colorectal cancer (CRC); classical Hodgkin lymphoma (cHL); hepatocellular carcinoma (HCC); Merkel cell carcinoma (MCC); mismatch repair deficient (dMMR); non-small cell lung cancer (NSCLC); renal cell carcinoma (RCC); squamous cell carcinoma of the head and neck (SCCHN). 1. Yervoy prescribing information (2015) Bristol-Myers Squibb Company. Accessed 15 January 2018. accessdata.fda.gov/drugsatfda_docs/label/2015/125377s073lbl.pdf. 2. Keytruda prescribing information (2014) Merck & Co., Inc. Accessed 15 January 2018. merck.com/product/usa/pi_circulars/k/keytruda/keytruda_pi.pdf. 3. Opdivo prescribing information (2018) Bristol-Myers Squibb Company. Accessed 15 January 2018. packageinserts.bms.com/pi/pi_opdivo.pdf. 4. Tecentriq prescribing information (2017) Genentech, Inc. Accessed 15 January 2018. gene.com/download/pdf/tecentriq_prescribing.pdf. 5. Bavencio prescribing information (2017) EMD Serono, Inc. emdserono.com/ms.country.us/en/images/Bavencio_PI_tcm115_161084.pdf. 6. Imfinzi prescribing information (2017) AstraZeneca Pharmaceuticals LP. Accessed 15 January 2018. azpicentral.com/imfinzi/imfinzi.pdf.
Table 2. Representative examples of investigational ICI agents.
rHIGM12B7 PD-L2 Phase I
Tremelimumab CTLA-4 Phase I–III
IMP321, BMS-986016 LAG-3 Phase I–II; Phase I–II
TSR-022 TIM-3 Phase I
PBF-509 A2aR Phase I
To learn more about ICI antibodies for flow cytometry, IHC, and functional bioassays, see the related article in BioProbes 75 Journal of Cell Biology Applications (May 2017) titled "Harness immune checkpoints to combat tumors" at thermofisher.com/bp75.
Immune modulation of the tumor microenvironment
The TME is composed of a complex network of tumor cells and cells of the stroma, immune system, vasculature, and extracellular matrices (Figure 1). Although tumor-infiltrating immune cells are present in the TME, the immunosuppressive milieu must be overcome to achieve antigen recognition, T cell priming and activation, and the expansion of tumor antigen–specific cytotoxic T cells. In addition to various cytokines that drive or inhibit immune responses, Figure 1 lists several T cell co-receptors (or their ligands), including ICIs, that are rational drug targets for immunotherapy—some of which are targets of cancer therapy agents approved by the US Food and Drug Administration (FDA). Table 1 provides details on the first-generation ICIs that are currently approved for indications in cancer. Figure 2 shows an example of Jurkat cells stained with a research antibody that recognizes the human CTLA-4 receptor.
Figure 1. The multistep anti-tumor responses. The cancer immunity cycle involves the coordination of a myriad of checkpoint molecules and other cell-surface receptors, as well as soluble factors such as cytokines and chemokines. The process is initiated by the release of tumor-derived antigens (step 1). The engulfment of these antigens by dendritic cells and their subsequent presentation to T cells (steps 2 and 3) drive the immune response. Once activated, effector T cells acquire the ability to destroy target cells by specifically recognizing tumor peptide–MHC complexes displayed on the tumor cell surface (steps 4–7). Increasing levels of tumor antigens are then released, further driving the progression of the cycle. ICIs have been shown to augment the T cell–mediated tumor rejection.
Figure 2. Immunofluorescence analysis of Jurkat cells using anti–CTLA-4 antibody. PMA-treated (left) and untreated (right) Jurkat cells were fixed and permeabilized for detection of endogenous CTLA-4 using Invitrogen ABfinity anti–CTLA-4 recombinant rabbit monoclonal antibody (clone 11H7L17) in conjunction with Invitrogen Superclonal goat anti–rabbit IgG (H+L) secondary antibody, Alexa Fluor 488 conjugate. Cell-surface localization of CTLA-4 protein is represented by the green signal. Nuclei (blue) were counterstained with Invitrogen SlowFade Gold Antifade Mountant with DAPI; cytoskeletal F-actin (red) was labeled with rhodamine phalloidin. Compared with the untreated cells in the right panel, cells treated with PMA (5 ng/mL, 48 hr; left panel) show an upregulation of CTLA-4 protein. The images were captured at 60x magnification on a Nikon Eclipse Ti-E Inverted Microscope.
Methods for identifying immune cells in TME, blood, and culture
Immune cell subsets within the TME include, but are not limited to, dendritic cells (DCs), natural killer (NK) cells, B cells, and T cells (including CD4+ T helper and regulatory subsets, CD8+ cytotoxic T cells with the potential to directly eradicate tumor cells, and other T cell subsets). The TME also harbors cells of the myeloid lineages, which may have both tumor-suppressive and tumor-promoting properties. The ability to isolate, characterize, and modulate cells that populate the TME is directly linked to advances in basic biomedical research and translational medicine. To learn more about leukocyte subsets and flow cytometry, access the T cell proliferation and stimulation ecourse.
Flow cytometry.Figure 3 illustrates how tumor-infiltrating lymphocytes (TIL) isolated from mice treated with or without anti–mouse CTLA-4 monoclonal antibody (mAb) may be evaluated ex vivo by multicolor flow cytometry—a powerful technology for phenotyping heterogeneous cell populations [4]. In this study by Draper et al., splenocytes were isolated from mice after administration of a total of 5 doses of anti–CTLA-4 mAb at 10 mg per kilogram of body weight, delivered 3 times weekly. Shown is the gating strategy used to define B cell, CD4+ helper T cell, Treg, CD8+ T cell, and NK cell populations. Cell proliferation was monitored by detecting the carboxyfluorescein succinimidyl ester (CFSE)–labeled leukocyte populations of interest. Use of this representative antibody staining protocol, CSFE labeling method, and gating strategy provides an effective way to evaluate the effects of ICI treatment in mouse tumor models. Learn more about the Invitrogen Attune NxT Flow Cytometer, flow cytometry reagents and antibodies.
Immunoassays for soluble proteins. In addition to implementing flow cytometry methods, immunophenotyping may be accomplished using sophisticated immunoassays that measure soluble proteins. The Invitrogen Immuno-oncology Checkpoint 14-Plex Human ProcartaPlex Panel 1 is a novel immunoassay that utilizes Luminex xMAP technology for the multiplex detection of the soluble immune checkpoint protein analytes displayed in Figure 4. An increasing number of studies suggest that these soluble proteins have the potential to function as decoy receptors or as immune adjuvants that may interfere with the efficacy of checkpoint modulator drug candidates. Additionally, evaluating soluble immune checkpoint protein biomarkers in sera or plasma of cancer patients may offer a minimally invasive method for correlating ICI treatment efficacy with analyte concentrations or for enabling identification of individuals that may or may not respond to a given ICI therapy.
This concept was first demonstrated in a study that reported a positive correlation between elevated serum levels of soluble CTLA-4 and clinical outcome benefit in patients treated with ipilimumab [5]. This ProcartaPlex panel is suitable for use with the Luminex 200, FLEXMAP 3D, and MAGPIX systems, and data for multiple analytes may be obtained from small sample volumes (25 μL for serum or plasma samples, 50 μL for cell culture supernatant). Similar to conventional immunoassays, antigen quantitation is accomplished using a fluorescently labeled secondary antibody, and signal intensity is proportional to the concentration of protein detected. Importantly, this multiplex assay produces results that overlap with those obtained with singleplex plate-based enzyme-linked immunosorbent assays (ELISA). Visit thermofisher.com/luminex to learn more about multiplex assays using Luminex technology and the ProcartaPlex immuno-oncology checkpoint panels in particular (Figure 4). For more information, read the application note "Detection of soluble isoforms of immuno-oncology checkpoint markers".
Cell imaging analysis. Both cell-imaging microscopes and high-content analysis (HCA) instruments are particularly robust tools that enable researchers to assess the structure, localization, and endogenous expression levels of proteins of interest and other cell characteristics. Invitrogen EVOS Cell Imaging Systems may be employed for transmitted-light imaging as well as colorimetric and fluorescence imaging for qualitative assessments; quantitative information about protein relocalization or organelle function can be obtained after importing images into data analysis software such as ImageJ. Figure 5 shows an example of data produced using the EVOS FL Auto Imaging System. Compared with observations in nonresponding metastatic melanoma patients treated with anti–CTLA-4 or anti–PD-1 mAbs, this immunohistochemical analysis indicates that, prior to treatment, statistically significant numbers of CD8+ T cells accumulated in the invasive margin of tumors from patients that responded to ICI therapy [6]. Learn more about EVOS Cell Imaging Systems.
High-content imaging and analysis. HCA technology combines high-resolution microscopy and automated image capture with multiparametric acquisition and data analysis to provide precise quantitative analysis of individual cells in a large and potentially heterogeneous cell population. With the aid of molecular tools such as fluorescent dyes, chemical probes, and targeted antibodies, a wide range of cell events and features can be quantitated, including but not limited to nuclei and DNA counts, nuclear and whole-cell morphology, and cytoskeletal organization, as well as cell motility, migration, and invasion [7]. In addition, these features can be quantitated over time to evaluate temporal and spatial relationships between multiple cellular targets in intact cells. An important advantage of HCA is the ability to perform multiple independent measurements simultaneously, and cell-based HCA assays are increasingly being used to monitor mechanisms critical in immuno-oncology research [8]. To produce the data presented in Figure 6, a Thermo Scientific CellInsight CX7 High-Content Analysis Platform was used to visualize effector T cell–mediated lysis of HCC827 cancer spheroids. Compared with the negative control conditions shown in the left panel, increasing the effector:target ratio resulted in a greater degree of target cell lysis, as seen in the right panel [9]. Learn more about Thermo Scientific high-content imaging and analysis instruments and reagents.
Figure 3. Profile of splenocytes (derived from a Balb/c syngenic CT26 colorectal tumor model) stimulated with anti-CD3 antibody. Tumor-naive and tumor-bearing mice were left untreated or administered anti–mouse CTLA-4 antibody. Subsequently, splenocytes were harvested, preloaded with carboxyfluorescein succinimidyl ester (CFSE), stimulated, stained, and analyzed on the Invitrogen Attune NxT Flow Cytometer. All procedures were performed according to the investigator's protocols. Data used with permission from David Draper and Alden Wong, MI Bioresearch, Ann Arbor, Michigan, USA.
Figure 4. Analysis of 14 soluble protein biomarkers in a single sample using a ProcartaPlex immunoassay. Standard curves are shown for the Invitrogen Immuno-oncology Checkpoint 14-Plex Human ProcartaPlex Panel 1.
Figure 5. Tumors responding to treatment show increased T cell infiltration prior to therapy.(A) Representative CD8+ immunohistochemical (IHC) staining of the invasive tumor margin and intratumoral region in pretreatment metastatic melanoma tumors (responding N = 4, nonresponding N = 4). Tumor compartments were assessed by a dermatopathologist. (B) Average CD8+ cell counts for responding and nonresponding tumor compartments. T cell counts were produced by averaging the counts of 10 randomly selected fields using a 20x objective for each tumor compartment (10 invasive margin; 10 intratumoral). RIM = responding invasive margin; NRIM = nonresponding invasive margin; RIT = responding intratumoral; NRIT = nonresponding intratumoral. Reprinted with permission from Shields B, Mahmoud F, Taylor EM et al. (2017) Sci Rep 7:807, and under the Creative Commons Attribution 4.0 International License (creativecommons.org/licenses/by/4.0/).
Alternative ICI T cell targets and additional strategies for cancer immunotherapy
The ICIs listed in Table 1 may become first-line therapies for certain advanced cancers; however, these treatments—either alone or in combination with other immunotherapy or chemotherapy agents—have been successful in a minority of patients. Table 2 provides a nonexhaustive summary of ICI drug candidates for the treatment of various solid and hematological tumors, administered alone or as combinatorial drug therapies with other ICIs or chemotherapy [10,11].
Beyond developing biotherapeutic antibodies that target immune checkpoint pathways, over the past few decades researchers have harnessed the power of adoptive cell therapies (ACT). For example, in adoptive T cell transfer, a patient's T cells are extracted, genetically modified to recognize the cancer cells, cultured in vitro, and then reintroduced into the patient. In 1988, autologous T cell adoptive transfer of ex vivo expanded cells was used with relative success to treat patients with metastatic melanoma resistant to conventional therapies, and incremental improvements in efficacy have emerged over time [12]. More recently, investigators have realized gains with the development of chimeric antigen receptor (CAR) T cell therapy for treating certain forms of cancer (Figure 6). In 2017, two CAR T cell therapies were approved by the FDA, opening the door for a new generation of ACTs.
Another emerging field inspiring great interest is immuno-metabolism, which explores intracellular metabolic pathways in immune cells. Among several focus areas, researchers are seeking to understand how drugs may selectively target metabolic pathways that govern T cell function and how alterations in T cell metabolism may potentially boost tumor rejection in vivo [13,14].
Figure 6. Chimeric antigen receptor (CAR) T cell invasion into cancer spheroids. HCC827 spheroids were formed using spheroid microplates for 48 hr. Then, 24 hr after the addition of EGFR scFv-CD28-CD3ε CAR T cells (ProMab Biotechnologies), spheroids were immunostained for cytokeratin-7 (green) and CD3ε (red), and counterstained with Hoechst dye (blue). As the effector-to-target ratio is increased from 10:1 (middle panel) to 40:1 (right panel), invasion of the CAR T cells into the HCC827 tumor spheroid and subsequent tumor cell lysis are visible. Images were obtained on the Thermo Scientific CellInsight CX7 High-Content Analysis Platform in confocal mode with a 10x objective, and used with permission from Corning Inc.
Download the Immuno-oncology Guide
To learn more about technologies that enable immuno-oncology research, download the Immuno-oncology Flow Cytometry Guide, which provides detailed information about workflows for flow cytometry, biomarker profiling, and cell imaging, and reviews several central aspects of cancer research.
"Global Cancer Facts & Figures" American Cancer Society. cancer.org/research/cancer-facts-statistics/global.html
Dimberu PM, Leonhardt RM (2011) Yale J Biol Med 84:371–380.
"Immunotherapy 2.0 named Advance of the Year in ASCO's 12th Annual Cancer Progress Report" ASCO, 15 Apr 2017. asco.org/about-asco/press-center/news-releases/immunotherapy-20-named-advance-year-asco% E2%80%99s-12th-annual-cancer
Draper D, Wong A, Saims D et al. (2017) "Abstract 5624: Characterization of proliferation in multiple lymphocyte subsets in the CT26 carcinoma model by multicolor flow cytometry". Presented at: American Association for Cancer Research Annual Meeting 2017; April 1–5, 2017; Washington, D.C., USA.
Weber JS (2017) "What has the checkpoint inhibitor experience in melanoma taught us about immunotherapy for other cancers?" ASCO Daily News.
Shields BD, Mahmoud F, Taylor EM et al. (2017) Sci Rep 7:807.
Fraietta I, Gasparri F (2016) Expert Opin Drug Discov 11:501–514.
Li L, Zhou Q, Voss TC et al. (2016) Methods 96:97–102.
Gitschier H (2017) Advanced Models for 3D Screening: Immune Oncology Applications. AACR April 2017. Accessed 8 January 2018. corning.com/media/worldwide/cls/documents/Advanced-Models-for-3D-Screening-Immune-Oncology-Applications.pdf
Tchekmedyian N, Gray JE, Creelan BC et al. (2015) Oncology (Williston Park) 29:990–1002.
Rosenberg SA, Restifo NP, Yang JC et al. (2008) Nat Rev Cancer 8:299–308.
O'Neill LA, Kishton RJ, Rathmell J (2016) Nat Rev Immunol 16:553–565.
Dugnani E, Pasquale V, Bordignon C et al. (2017) Cancer Lett 411:12–18.
702534,11-9969-41,14-9989-82,PA520343,12-5982-82,12-5983-42,11-9972-82,11-2239-42,67-3109-42,PA1042,EPX14A-15803-901,EPX140-15815-901,CX7A1110,A29004,A29003,A29002,100022777,AMAFD2000
Immune checkpoint proteins and immune cell functionality
Immuno-oncology research using flow cytometry
Recently approved CAR T cell therapy for a form of pediatric leukemia
Antibodies for flow cytometry
Immune checkpoint antibodies for flow cytometry, IHC, and functional bioassays—BioProbes 75 Journal of Cell Biology Applications
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Q: Implementing the Expanding Polytope Algorithm in 3D Space I'm trying to implement the EPA algorithm in 3D space but I seem to have found a situation when the convex simplex can turn into a concave one.
Consider this simplex:

And because it's hard to see what's going on here it is animated:

The origin is the red, green and blue axis helper. The white sphere with no edges connected to it represents the point where I need to expand the polytope to next. The 5 yellow arrows are the normals of the faces that should be removed since they're in the same direction as the origin to the new point. Some faces don't look to be in the same direction but I've verified that they are as the dot products with the face normal and new point are:

*

*0.45396564417079877

*0.9473689548609279

*0.3346846050014339

*0.09982613239032267

*0.09982617482390854

So those two faces on the right side of the .gif are just barley in the same direction.
Okay so the EPA algorithm says to remove those faces:

Then construct new faces to the new point using the remaining edges from the faces we removed. But you can see now that the convex simplex has turned into a concave one:

This is obviously not right but I'm not sure where I went wrong. It feels to me like I've removed faces I shouldn't have but those faces are in the same direction as the new point.
Here is my code:
var EPA = function(aWorldVerts, bWorldVerts, simplex) {
    var simplexFaces = [{a: 0, b: 1, c: 2},
                        {a: 0, b: 1, c: 3},
                        {a: 0, b: 2, c: 3},
                        {a: 1, b: 2, c: 3}];

    var ret = null;

    while(true) {
        var face = findClosestFace(simplex, simplexFaces);
        var point = support(aWorldVerts, bWorldVerts, face.norm);
        var dist = point.clone().dot(face.norm);

        if(dist - face.dist < 0.00001) {
            ret = {axis: face.norm, dist: dist};
            break;
        }

        simplex.push(point);
        reconstruct(simplex, simplexFaces, point);
    }

    return ret;
}

var reconstruct = function(simplex, simplexFaces, extendPoint) {
    //I do realize that this function can be done more efficietly
    var removalFaces = [];
    for(var i = 0; i < simplexFaces.length; i++) {
        var face = simplexFaces[i];

        var ab = simplex[face.b].clone().sub(simplex[face.a]);
        var ac = simplex[face.c].clone().sub(simplex[face.a]);
        var norm = ab.cross(ac).normalize();

        var a0 = new THREE.Vector3().sub(simplex[face.a]);
        if(a0.dot(norm) > 0)
            norm.negate();

        if(extendPoint.clone().dot(norm) > 0) {
            removalFaces.push(i);
        }
    }

    //get the edges that are not shared between the faces that should be removed
    var edges = [];
    for(var i = 0; i < removalFaces.length; i++) {
        var face = simplexFaces[removalFaces[i]];
        var edgeAB = {a: face.a, b: face.b};
        var edgeAC = {a: face.a, b: face.c};
        var edgeBC = {a: face.b, b: face.c};

        var k = edgeInEdges(edges, edgeAB);
        if(k != -1)
            edges.splice(k, 1);
        else
            edges.push(edgeAB);

        k = edgeInEdges(edges, edgeAC);
        if(k != -1)
            edges.splice(k, 1);
        else
            edges.push(edgeAC);

        k = edgeInEdges(edges, edgeBC);
        if(k != -1)
            edges.splice(k, 1);
        else
            edges.push(edgeBC);
    }

    //remove the faces from the polytope
    for(var i = removalFaces.length - 1; i >= 0; i--) {
        simplexFaces.splice(removalFaces[i], 1);
    }

    //form new faces with the edges and new point
    for(var i = 0; i < edges.length; i++) {
        simplexFaces.push({a: edges[i].a, b: edges[i].b, c: simplex.length - 1});
    }
}

var edgeInEdges = function(edges, edge) {
    for(var i = 0; i < edges.length; i++) {
        if(edges[i].a == edge.a && edges[i].b == edge.b)
            return i;
    }

    return -1;
}

var findClosestFace = function(simplex, simplexFaces) {
    var closest = {dist: Infinity};

    for(var i = 0; i < simplexFaces.length; i++) {
        var face = simplexFaces[i];

        var ab = simplex[face.b].clone().sub(simplex[face.a]);
        var ac = simplex[face.c].clone().sub(simplex[face.a]);
        var norm = ab.cross(ac).normalize();

        var a0 = new THREE.Vector3().sub(simplex[face.a]);
        if(a0.dot(norm) > 0)
            norm.negate();

        var dist = simplex[face.a].clone().dot(norm);

        if(dist < closest.dist) {
            closest = {index: i, dist: dist, norm: norm, a: face.a, b: face.b, c: face.c};
        }
    }

    return closest;
}

var support = function(aVerts, bVerts, dir) {
    a = getFurthestPointInDirection(aVerts, dir);
    b = getFurthestPointInDirection(bVerts, dir.clone().negate());
    return a.clone().sub(b);
}

var getFurthestPointInDirection = function(verts, dir) {
    var index = 0;
    var maxDot = verts[index].clone().dot(dir.clone().normalize());

    for(var i = 1; i < verts.length; i++) {
        var dot = verts[i].clone().dot(dir.clone().normalize());

        if(dot > maxDot) {
            maxDot = dot;
            index = i;
        }
    }

    return verts[index];
}

I know the support function works correctly as well as findClosestFace() and edgeInEdges(). Also, it shouldn't matter but this is implemented using Three.js and Javascript. Maybe I'm just fundamentally misunderstanding how the algorithm works?
What have I done wrong and how can I fix it?

A: Many hours of debugging later I've found my problem. The faces you want to remove before extending the polytope to the new point are not found by checking if the normal of the face is in the same direction as the origin to the new point. Many articles on this topic say you want to remove the faces that the new point can "see" which I took to mean the normals are in the same direction. This is not the case because you can very well have a face normal in the same direction as the origin to the new point however the face can't be "seen" by the point so removing it would be problematic which is what I was doing. You want to essentially imagine you're camera to be exactly where the new point is, look around and any face you can see should be removed.
To check if a given face can be "seen" by the new point you want to form a vector from a vertex of said face to the new point and check the dot product of that with the face normal. So I replaced if(extendPoint.clone().dot(norm) > 0) with if(norm.clone().dot(extendPoint.clone().sub(simplex[face.a])) > 0) in the reconstruct() function and it now works.


Agenor Asteriadis began his artistic training at the Athens School of Fine Arts. He was guided by various artists, among them Georgios Roilos, Sypros Vikatos and Nikolaos Lytras. After Asteriadis graduated, he started exhibiting and held his first solo exhibition in Larissa. His career went on to flourish and he participated in the Venice Biennale in 1934 and 1940, and subsequently became a member of the Greek Artists' Association.
Asteriadis's artistic talents were versatile and he worked with murals, frescoes, mosaics and illustrated books. During the German occupation, he published posters of his engravings that had been inspired by folk songs. His compositions ranged from landscapes to nudes and still lifes. He died in Athens in 1977 after having spent almost 10 years teaching drawing at the Zanneio Orphanage in Piraeus.


text:
Q: QT Quick Test KeyClicks I am trying to implement a keyClick with a shift modifier but it doesn't work. Below is a basic setup of what I am trying to do. The first test_case1 can perform what I am doing but I'd like the second test_case2 to work as well but with using the Qt.ShiftModifier.
../MyTextBox.qml
Page {
    id: page1
    objectName: "page1"

    TextField {
        id: lastNameField
        objectName: "lastNameField"
        text: qsTr("")
    }
}

tst_page.qml
import "../"

Item {
    width: 800
    height: 600

    MyTextBox {
        id: page1
    }

    TestCase {
        id: "txtBox"
        when: windowShown

            function test_case1 () {
                //var qmlObj = findChild(page1, "lastNameField")
                var qmlObj = page1.lastNameField
                // Bring to focus
                mouseClick(qmlObj, Qt.LeftButton, Qt.NoModifier)
                // Keypress
                keyPress("Y")
                keyPress("e")
                keyPress("s")

                tryCompare(qmlObj, "text", "Yes") // pass
            }

            function test_case2 () {
                var qmlObj = page1.lastNameField
                // Bring to focus
                mouseClick(qmlObj, Qt.LeftButton, Qt.NoModifier)
                // Keypress
                keyClick(QT.Key_Y, Qt.ShiftModifier)
                keyClick(QT.Key_E)
                keyClick(QT.Key_S)

                tryCompare(qmlObj, "text", "Yes") // fail
            }
     }
}

test output
PASS   : test_case1()
FAIL!  : test_case2()
   Actual    (): yes
   Expected  (): Yes

Edit: Added a simple project to github for testing.


Perfect for keeping your favorite deck of cards flat and fresh every time you are ready to work your magic! This limited edition Classic Clip is crafted by renowned artisan and technical genius, Joe Porper in Los Angeles, California. The clip is made from black anodized, aircraft grade aluminum alloy, and is hallmarked with Joe Porper's signature. The Spectral Motion logo is laser etched on this beautiful clip. Designed to hold a standard deck of 52 playing cards stored in their case.


text:
Bow Wow Gets Major Clap Back After Performing In Packed Houston Club Amid Coronavirus Pandemic
Tracee Ellis Ross, 48, Looks Identical To Her Mom Diana Ross In Metallic Crop Top — See Pic
Justin Bieber Shows Off Muscles & Tattoos In Sleeveless Top As He Rides A Motorcycle For New Video Shoot
Delilah Belle Hamlin, 22, Wears Lacey White Lingerie As She Lounges In Bed — See Pics
Treat Yourself With These Relaxing Bath Bombs That Have Over 25k Reviews & Are Under $30
Rita Ora, 29, Sparks Dating Rumors With Jude Law's Look-Alike Son, 23, On Night Out — Pic
December 5, 2019 10:40AM EST
Joe Jonas Proves He's A Fan Of Ex Taylor Swift By Serenading Nick With her Song 'Lover'
View Gallery View Gallery 8 Photos.
Music & Sports Editor
Clearly, there is no bad blood between Joe Jonas and Taylor Swift. The DNCE star showed his ex some love by singing a touching version of her song, 'Lover,' to his brother, Nick Jonas. Really.
Taylor Swift, 29, and Joe Jonas, 30, only dated for a handful of months in 2008, but it wasn't the most pleasant of breakups. In the decade since their split, the two have patched things up, so much to the point that they can publicly show love for each other's music without it being a thing. Take, for instance, the video Joe uploaded to his Instagram Story on Dec. 4. As he and Nick Jonas, 27, were traveling, Joe felt inspired to sing. The DNCE frontman belted out the chorus to Taylor's "Lover," while changing the lyrics at the right moment. "My! My! My! Brother."
Fans will now wait to see if Taylor responds by changing up "Sucker" to be about one of her cats (actually, Swifties will be listening to Taylor's new Christmas song, which she announced on Dec. 5.) As for Joe and Taylor, it's good to know these two are at a spot where he can sing her songs. The couple didn't have the best breakup. "When I find that person that is right for me he'll be wonderful," Taylor said on the Ellen show in November 2008, one month after the split, "and when I look at that person, I'm not even gonna be able to remember the boy who broke up with me over the phone in 25 seconds when I was 18."
Yes, Joe famously ended things with Taylor with a phone call. She would turn lemons into lemonade by transforming her heartbreak into her track, "Forever & Always." It's a song that doesn't hold anything back. "Was I out of line? / Did I say something way too honest, made you run and hide/ Like a scared little boy." Joe seemingly responded a year later with 2009's "Much Better," a song that Billboard noted references Taylor's "Teardrops On My Guitar."
📹 IG | Joe Jonas singing #Lover to Nick Jonas via Instagram story pic.twitter.com/DiojPZFNB7
— Taylor Swift News (@TSwiftNZ) December 5, 2019
Speaking of her guitar, Taylor gave Joe a shoutout a year after the breakup during a November 2009 episode of Saturday Night Live. "You might think I'd bring up Joe, that guy who broke up with me on the phone. But I'm not going to mention him in my monologue song," she sings. "Hey, Joe! I'm doing real well, and I'm hosting SNL — but I'm not going to write about that in my monologue song."
Thankfully, the two seemed to be cool by 2015. After the two were seen hanging out at the Billboard Music Awards, Joe told Access Hollywood that he and Taylor were "friends." In May 2019, Taylor went on Ellen and apologized for "putt[ing] Joe Jonas on blast…that was too much." A month later, Joe — who noted that he and Taylor were teenagers when this all went down — accepted the apology and said, "It's all good. We were so young."
Joe Jonas	Taylor Swift
More Related News:
Taylor Swift Says She Was 'Slut-Shamed' Because She Dated Men Like Harry Styles & Joe Jonas
Sophie Turner Snoops On Joe Jonas' Cell Phone As They Spend Downtime Together In L.A.
Sophie Turner Trolls Hubby Joe Jonas After He Says Working With Coors Light Was His 'Best Day Ever'
Meghan Markle & Prince Harry Are Happy in California But Royal Split Still Weights On Them
Five-0 Final-Season Mystery Is Solved
Gigi Hadid Makes The Case For Her Go-To Dr. Martens Boots In This Buzzy Hue


MANSFIELD - It is that time again to vote for the Mansfield News Journal Female Athlete of the Week.
>> Ashland's Alyssa Struey became just the fourth girl in Ashland history to record 1,000-career points. She scored 30 in a win over Mount Vernon to achieve the milestone.
>> Lexington's Olivia Newman won the 50 free while also being a part of the winning 200 medley relay team at the sectional swim meet.
>> Plymouth's Tristen Wiley had games of 18 and 14 points in two Lady Big Red wins last week.
>> Crestview's Kenedi Goon had games of 21 and 16 points in a pair of Lady Cougar wins last week.
>> Shelby's Bailey Walter scored 23 points in a win over River Valley to give the Lady Whippets a perfect Mid-Ohio Athletic Conference record.


text:
1.1. for the sake of the people and the nation
1.2. the white fathers
1.3. no matter who "osei kofi tutu i" is
1.4. 1905 & the muslim exception
1.5. a not-so-secular state culturalism
1.6. the phantom menace
1.7. g. kepel, president whisperer
1.8. dismissed
1.9. their turn trying to rule the world
1.10. just a matter of time
childish, wild billy & the blackhands
live in the netherlands
7" € 11,99
dylan, bob
l'epee
LP+CD € 21,99
orbison, roy
and the teen kings
pop, iggy
bookies club 870
Label: LÖVELY RECORDS
nightwatchers
common crusades
common crusades (clear)
la paix ou lesable
common crusades (marbled)
(MARBLED)
Item has not been released; estimated delivery in Germany on 29.01.2022. Item will be shipped immediately once it is in stock.
In stock. Delivery in Germany in 2-3 working days
Black/White Marbled vinyl. Limited to 500 copies. "Common Crusades" is the second full-length from French Nightwatchers, and the musical and lyrical continuity of their 2019 thematic debut "La paix ou le sable". Political lyrics dealing with the conflicts rooted in France's colonial era clash with melodic, subversive, and gloomy and soundscapes throughout the tracks of "Common Crusades". An album that is as musically captivating as politically current. "Common Crusades" offers 10 melodic punk rock tracks, all contributing to the overall story and theme of the album. Fast-paced, distorted, and punchy cuts are mixed with tracks highlighting a colder and post-punk influenced side of Nightwatchers. The sound is perfectly captured by studio engineer ... read more
Black/White Marbled vinyl. Limited to 500 copies. "Common Crusades" is the second full-length from French Nightwatchers, and the musical and lyrical continuity of their 2019 thematic debut "La paix ou le sable". Political lyrics dealing with the conflicts rooted in France's colonial era clash with melodic, subversive, and gloomy and soundscapes throughout the tracks of "Common Crusades". An album that is as musically captivating as politically current. "Common Crusades" offers 10 melodic punk rock tracks, all contributing to the overall story and theme of the album. Fast-paced, distorted, and punchy cuts are mixed with tracks highlighting a colder and post-punk influenced side of Nightwatchers. The sound is perfectly captured by studio engineer Mathieu Zuzek. "Common Crusades" tackles the same issues that shaped Nightwatchers debut album "La paix ou le sable", but from a different perspective. Both albums deal with events surrounding France's violent colonization and exploitation of their occurred territories. While the lyrics of "La paix ou le sable" is based on excerpts taken from two historical books and written with the objective of raising awareness of France's colonial violence, "Common Crusades" mainly focuses on the aftermath of these conflicts, and how the colonial era still affects modern day France. In particular, its muslim population. All the lyrics of "Common Crusades" are based on speeches or writings of personalities who played a role in the colonization process, as well as those who currently play a role in the perpetuation of colonial logic within the French society. The band explains that; Released on Vinyl and CD. The first pressing of the vinyl is released on two vinyl colors limited to 500 copies each. One pressing on Black/White Marbled Vinyl and one pressing on Clear/Transparent vinyl. The CD is released with Digi pack cover.


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Andrea Gard is the author of two story collections and two novels, most recently Eat Only When You're Hungry. She lives in Chicago.


text:
Q: Are electromagnetic waves only caused by accelerating charges? Like the title says, are electromagnetic waves only caused by accelerating charges? Are there any other methods for the generation of photons?
If electromagnetic waves are ONLY able to be created by accelerating charges, why is it that when an electron absorbs a photon (and it gets accelerated) it doesn't emit an electromagnetic wave?

A: The classical electromagnetic waves as modeled by Maxwell's equations solutions, are one framework, the classical one.
Electrons and photons are elementary particles and are in the quantum mechanical framework.
The classical framework, emerges smoothly  from the quantum framework at the overlap kinematic regions. One cannot use the same mathematics without critical thinking.
The electron does not absorb a photon. A free electron interacts with a photon according to quantum electrodynamic rules, and it is not a classical electrodynamics acceleration or deceleration. An electron bound to matter changes energy levels and the photon is absorbed or emitted from the atom/molecule/lattice. All these interactions are calculable with Feynman diagrams.

For example these are the first order diagrams that contribute to the free electrom photon interaction that can be used to give the probability of interaction and statistical plots of energy and momentum.
How classical fields emerge from quantum is a story that needs the mathematics of quantum field theory.
The classical observation that accelerating charges create electromagnetic waves as well as changing magnetic fields may also do, is beautifully explained with the classical electrodynamics of Maxwell's equations.

A: There are a few ways to create photons:

*

*accelerating charges (like in your example), but based on the comments, you need to count accelerating magnetic dipoles too.

https://physics.stackexchange.com/a/65350/132371

*electron relaxation, that is when an excited electron as per QM at a higher energy level moves to a lower energy level, and the difference in energy is emitted as a photon

https://en.wikipedia.org/wiki/Electron_excitation

*molecules rotational, vibrational energies can be converted to photon emission.

https://en.wikipedia.org/wiki/Emission_spectrum
Emission can happen in two ways:

*

*spontaneous emission, when a QM system transitions from an excited state to a lower energy state and emits a photon

https://en.wikipedia.org/wiki/Spontaneous_emission

*stimulated emission, is when an incoming photon with specific energy can interact with an excited electron, causing it to drop to a lower energy level

https://en.wikipedia.org/wiki/Stimulated_emission
Now I understand you are confused because when an electron absorbs a photon, it moves to a higher energy level as per QM. This move is what you imagine as a classical move and acceleration. In reality, this electron does not accelerate, it just moves to a higher energy level as per QM. After this excitation, the electron will relax. This relaxation is when the electron moves back to a lower energy level, and emits a photon. Still, the electron does not accelerate as it moves to a lower energy level, as per QM. It is the difference in energy level (of the electron/atom) that is emitted as a photon. The electron does not accelerate as it moves between the energy levels as per QM, it just starts existing at a different energy level as per QM.

A: EM fields are only coupled to charge-current, so propagating fields can only be absorbed or emitted in principle by accelerating charges.
Nevertheless one can distinguish electric and magnetic dipole radiation. Higher multipole radiation also exists. The first describes atomic and molecular transition, electronic or optical active vibrational and rotational. The latter describes ordinary emission of radiation signals (orbital magnetic moment) , the hydrogen 21 cm line, EPR, NMR , MRI.
Nevertheless, the magnetic multipole radiation comes from changing electric current. Current can only change if charge is accelerated. This is even true for time varying spin density , the divergency of which is a time varying current.


Tenant Review: his guy is fraud . He lead me on for 1 week until I found out that he was trying to rip me off. He asked me to give him $2000 to sublease his apartment through him.
Landlord Response: Mike first contacted me inquiring about my apartment, and we informed him that we are not available at the property location and my friend who is there can show him the place around and if he is satisfied he can pay an advance and move-in on the same day. Mike called and informed me that he wanted to go to the leasing office and change my leasing information for which I told him will not work with our agreement as the lease is in my name and our offices will not permit this. I suggested him if getting a lease on his name is the requirement then he can get an apartment by lease directly but he said he has some bad history and rental agencies will not lease him apartment. He then started using foul language saying we cheated him and sent messages with profanity in which I blocked him to prevent any further issues.


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It's been one month since the pre-orders campaign ended for my latest book, Innovation Wars.
on May 2, 2016, 12:47 a.m.
Excited to get my copy of Innovation Wars!
on May 2, 2016, 4:55 a.m.
Congrats Scott! You're an ongoing inspiration :) can't wait to read Innovation Wars!
on May 17, 2016, 6:51 a.m.
Scott certainly knows what he is talking about, you should listen to him before taking on any corporate innovation programmes.
on May 19, 2016, 10:03 a.m.
Can't wait to read this Scott! Congrats on finishing and delivering another book to the world. Wonderful.
on May 31, 2016, 7:22 a.m.
on May 31, 2016, 10:10 a.m.
on May 31, 2016, 10:11 a.m.
on June 1, 2016, 12:28 p.m.
Excited I've just ordered my copy of 'Innovation Wars' by Scott Bales. Absolutely agree that you've got to beyond denial and through despair to build the awareness and confidence to tackle digital transformation & build an innovation culture!
on June 1, 2016, 4:40 p.m.


text:
Rona Ambrose
Cabinet committee, President of the Queen's Privy Council for Canada, Edmonton—Spruce Grove
St. Andrew's Evangelical Lutheran Church Complex
U.S. National Register of Historic Places in New York
Vladimir Komarov
Aerospace engineering, Voskhod 1, Soyuz 1, Spaceflight
Bistum Santander
Römisch-katholische Kirche, Diözese, Santander, Spanien, Benedikt XIV., Erzbistum Burgos, Erzbistum Burgos
Religion / Théologie
Bandysie
Gmina, Village, Gmina Szamocin, Chodzież County, Greater Poland Voivodeship
Vladimir Nikitin
FIS Nordic World Ski Championships 1982, Olympic Games, 1984 Winter Olympics, Cross -country skiing
Vladimir Potkin
Grandmaster (chess), European Individual Chess Championship, Denis Khismatullin, Evgeny Tomashevsky
West African Pilot
Nnamdi Azikiwe, Nigerian Youth Movement, Gani Fawehinmi
Vladimir Quesada
C .D. Saprissa, CONCACAF Champions League, 1990 FIFA World Cup, Santos de Guápiles
Ronald Zubar
Wolverhampton Wanderers F.C., Premier League, Sami Al-Jaber


text:
TLD/Lucas Oil Honda Race Report: Seattle
April 26, 2010 5:08pm
On what was undoubtedly one of the most brutally demanding supercross tracks ever built, Troy Lee Designs / Lucas Oil / Honda rider Wil Hahn gritted out a second place finish and moved himself to second in the series standings. His teammate, Cole Seely, toughed out a seventh place finish despite a poor start.
Lining up for the main event it was clear that Hahn meant business. His lap times were good and he knew he was prepared to ride at 100% for the entire fifteen laps. The Young rider from Texas was third coming around the first turn but ran into the back of Trey Canard when he fell in turn two. The mishap dropped him to fifth where he would begin an impressive charge towards the front. By the time he moved into second the leader was already several seconds ahead and the margin was too much for Wil to close. Although he wants a win baldly, Hahn rode well and he was proud of that.
"Man, I really felt like tonight was my night to win," He said after the race. Adding, "I know it's coming... I've been working way too hard not to win one of these. I can't take anything away from (Broc) Tickle though; he rode great tonight. He was flying out there. Next week we'll just get back to work and see if we can get a win in Salt Lake City."
Seely was mired in the pack and lost all of his tear-offs early, forcing him to remove his goggles. The race became about survival for him after that point. Cole would soldier on to a seventh but he was visibly disappointed with the way his night went.
"That definitely wasn't how I wanted the night to go," Cole explained. "All night I just felt tight and like I was fighting the bike. When I reached up on the second lap of the main to pull a tear off and I grabbed all of them, I knew I was in trouble. I tried wiping them as long as I could but I couldn't see a thing. I had to throw them and it made it tough to get close to anyone after that. I need to have a good race next weekend to bounce back from this."
The team will now head to Utah for the final round of the west region series. Wil has a five point lead over Canard and he is nineteen points down on Jake Weimer. It is a long shot to win the title but crazier things have happened.
The Monster Energy AMA Supercross Series heads to Rice-Eccles Stadium in Salt Lake City on Saturday, May 1.
The Troy Lee Designs Lucas Oil Honda race team would like to thank all of the companies that have supported our racing efforts over the years. They include Lucas Oil, American Honda, Red Bull, PPG, Wings for Life, Alpinestars, Avia, Couts Heating and Cooling, Dunlop, Epic Action Video Cam, Leatt Brace, McQueen Racing, Oakley, Pacific Collision, Pro Circuit, Rossignol, Santa Cruz, Selle Italia, Skullcandy, All Sport Dynamics, Cycra, Fasthouse, Flexfit, Hinson Clutch, Hot Wheels, Kahne Racing, Light Speed, Muc-Off, N Style, Nameplate, ODI, Primm, QTM, Renthal, RK Chain, Excel, Twin Air, Vasser Racing and VP Racing.
Follow the Troy Lee Designs / Lucas Oil / Honda team at www.troyleedesigns.com
Gravitt Racing's Randy Childers Injured 4:24pm
Weimer Extends Championship Lead 5:10pm


I saw this report of a chain pickerel being caught out of liberty res and was a bit surprised this is the first time I heard about anyone catching one out of liberty. I was wondering if any of you have heard about chain pickerel being in liberty?
I did catch a chain pickerel in liberty 3 or 4 years ago in a Metro tournament up in Cooks. I thought it was my 8th keeper of the day at 3:00. PM. That is the only one I know about. I sure hope with all the grass now at the lower end we don't end up with them like Loch Raven.


Whether you are a first timer or an experienced fisherman, we have amazing salmon adventures to offer spring, summer, and fall!
There is nothing quite like the burying of the rod when a chinook or coho decide to bite. If this is what you're after, you've come to the right place!
Springers are the bell of the ball when it comes to table fare and can be pretty wily on hook and line. I provide trips for these prized salmon beginning in March and running into July. My regular haunts include the Columbia and Willamette rivers. Make a full day out of it or just join me for a morning or evening fish. Proximity to Portland is great on these trips.
The Buoy 10 Fishery, located at the mouth of the Columbia River, offers the worlds largest salmon run. With numbers often eclipsing 1 million fish, August and September boast numerous amazing days of fishing. I spend nearly two full months a year here, and it is a marquis fishery that you'll really want to enjoy for yourself. Big Columbia Kings and scrappy Coho compromise our catch, and the action is regularly fast and furious!
After the action at the Buoy 10 fishery subsides, I move our operations south to the fertile coastal estuaries of north coast Oregon including Tillamook, Siletz, and Alsea Bays. The returning salmon here are often massive and the settings are serene as we fish while being surrounded by the colorful landscapes of the Autumn months.
Salmon trips vary in pricing depending on seasons and locations, ranging from $160 – $200 per person. Please contact us today for rates!
If you are interested in scheduling a trip with me please use one of the many contact forms on the site including the one below or simply give me a call and I will take care of the rest. Thank you for your interest and hope to see you one a trip sometime soon!
From drift boat float trips to outings with family and friends in our 25' guide sled, we have many adventures to choose from! You'll find us steelhead fishing near Tillamook and Newport, OR among other places. We offer walleye, sturgeon and perch trips in locations such as Rufus, The Dalles, and Warrenton, OR. Our crab and clams trips are regularly done in Gearhart, Tillamook Bay and Alsea Bay, OR. Mushroom and berry picking adventures are near the forest of Spruce Run Park in Seaside. Give us a call to book your trip today!


text:
Syngonium hastifolium är en kallaväxtart som beskrevs av Adolf Engler. Syngonium hastifolium ingår i släktet Syngonium och familjen kallaväxter. Inga underarter finns listade.

Källor

Kallaväxter
hastifolium

redpajama_set_name: RedPajamaWikipedia


text:
Watch the replay on YouTube: https://www.youtube.com/watch?v=OI19lvc2Wvw
This is a recording of a live webinar captured on May 4, 2020, titled "Defusing Teen Stress: Navigating Tough Times and Finding Healing" — addressing the topic of stress, depression, suicide, and other major challenges faced by the youth of today.
Helpful additional resources
Crisis and Suicide Hotlines:
In Contra Costa County:
Text HOPE to 20121
National Suicide Prevention Lifeline: 1-800-273-TALK (8255)
National Crisis Text Line: send text to 741741
Practitioners of Christian Science, ready to help:
Brian Talcott, CSB (510) 301-8400 btalcott@comcast.net
Pamela deBolt, CSB (707) 321-9800 dbltp@aol.com
Find a Christian Science Practitioner near you:
https://www.christianscience.com/find-us/find-a-christian-science-practitioner
Articles for youth from The First Church of Christ, Scientist, Boston:
Teen Connect: Out of the depths of depression
Teen Connect: Thinking about suicide?
Additional resources for teens
Get in touch with our panelists:
Graham Wiseman (925) 209-6685 graham@beingwellca.org
Scott Chavez ScottC@crisis-center.org
Melanie Wahlberg, CS (818) 300-1793 melaniewahlbergcs@gmail.com
This event is sponsored by First Church of Christ, Scientist, Pleasant Hill, CA, and First Church of Christ, Scientist, Orinda, CA
Graham Wiseman
Co-Founder & CEO, BeingwellCA
Graham spent 25 years in the corporate world working with clients such as: University of California, SF Giants and Centers for Medicare / Medicaid, New York. As a trusted advisor to five San Francisco Police Chiefs, he built a reputation for tackling complex issues and delivering simple, thorough solutions. After a tragic loss in his life, Graham left corporate sales and devoted his career to providing students, parents and education professionals with strategies and solutions to address the increasing mental health issues in our communities.
Scott Chavez, M.Div
Outreach and Training Lead at the Contra Costa Crisis Center
Scott Chavez began serving as a crisis line volunteer on the Crisis Center's 24-hour crisis & suicide hotlines in 2010. He joined the agency's staff in 2013 and continues to provide crisis counseling, support, & resource information to people in crisis, including those at risk of suicide. In addition, Scott provides trainings in suicide prevention and suicide intervention skills for the agency's staff and volunteers and throughout Contra Costa County.
Melanie Wahlberg, CS
Christian Science Practitioner & Lecturer
Melanie Wahlberg originally pursued a career as a college mathematics professor, achieving a doctorate in mathematics. She is now a member of the Christian Science Board of Lectureship and travels frequently from her home in Southern California, speaking to audiences about prayer, Christian Science healing, and solving challenges by applying a spiritual perspective. As the mother of three teens, she speaks from practical experience.
1 thought on ""Defusing Teen Stress: Navigating Tough Times and Finding Healing" — Live webinar with Graham Wiseman, Scott Chavez, M.Div, and Melanie Wahlberg, CS"
Pam Wade May 13, 2020 Reply
This was an excellent program. I'm so glad I caught it. I look forward to sharing it with a friend.
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