text:
Clin Pharmacokinet (2014) 53:863–864 DOI 10.1007/s40262-014-0186-6
Protein Engineering for Improved Pharmacologic Characteristics of Established Monoclonal Antibody-Based Therapeutics Bernd Meibohm
Published online: 12 September 2014 Ó Springer International Publishing Switzerland 2014
Since the widespread clinical introduction of chimeric, humanized and human monoclonal antibodies more than 15 years ago, monoclonal antibody based therapeutics have conquered substantial ground as major players and in some indications even cornerstones in the pharmacotherapeutic management of a variety of serious medical conditions [1]. While monoclonal antibodies with novel targets and antibody based derivatives such as antibody-drug conjugates, antibody fragments, antibody-based fusion proteins, bispecific antibodies, nanobodies and similar constructs have received much attention in recent years [2, 3], refining and optimizing the protein structure and subsequently pharmacologic properties of established, clinically used monoclonal antibodies is gaining increasing interest. While this effort is likely partly driven by patent expirations and the growing momentum for establishing a viable and effective biosimilar market for monoclonal antibodies in many nations [4], it also opens a pathway to apply recent advances in protein engineering and manufacturing to create derivatives that form a new, improved generation of established therapeutic proteins. The article by Othman et al. [5] in this issue of Clinical Pharmacokinetics describes a population pharmacokinetic analysis for one such next-generation monoclonal antibody, daclizumab high yield process (HYP) as improved version of daclizumab (ZenapaxÒ). While daclizumab is approved in the US for prophylaxis of acute organ rejection in patients receiving renal transplants, daclizumab HYP seeks to gain approval for a new indication, relapsing-remitting multiple
B. Meibohm (&) College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Rm. 444, Memphis, TN 38163, USA e-mail: [email protected]
sclerosis, competing with a number of other established therapeutic proteins including interferon beta-1a, interferon beta-1b, natalizumab, and the polypeptide glatiramer acetate. Compared to daclizumab, daclizumab HYP is characterized by improved production and purification processes, which result in distinct differences in the heavy chain N-terminal sequences as well as the glycan structure. Compared to daclizumab, the daclizumab HYP glycan pattern is substantially less heterogeneous, with a homogenous N-linked glycosylation profile and a lack of nonfucosilated forms. As afucosulation has been described as a major driver for antibody-dependent cellular cytotoxity [6], lack of this glycan structure in daclizumab HYP minimizes any antibody dependent cellular cytotoxicity (ADCC)-related effector function which has been confirmed experimentally [7]. Similarly, the modified antibody structure may affect the immunogenicity and clearance of daclizumab HYP. The population pharmacokinetic analysis by Othman et al. [5] seems to confirm differences in the pharmacokinetic behavior between daclizumab and daclizumab HYP. Although previous public reports on daclizumab pharmacokinetics have been limited, the presented results suggest that daclizumab HYP has an approximately 30 % reduced systemic clearance compared to daclizumab. This observation would be consistent with a reduction in ADCC and Fc-receptor-mediated elimination. Future investigations may reveal additional improved pharmacologic properties of daclizumab HYP compared to daclizumab, for example with regard to immunogenicity or pharmacologic efficacy. Overall, this example shows how slight structural modifications by protein engineering can be utilized to optimize the pharmacologic profile of established monoclonal antibody-based therapeutics to produce the next generation of therapeutic proteins with an improved therapeutic profile.
References 1. Dirks NL, Meibohm B. Population pharmacokinetics of therapeutic monoclonal antibodies. Clin Pharmacokinet. 2010;49(10):633–59. 2. Kontermann RE. Dual targeting strategies with bispecific antibodies. MAbs. 2012;4(2):182–97. 3. Wu AM, Senter PD. Arming antibodies: prospects and challenges for immunoconjugates. Nat Biotechnol. 2005;23(9):1137–46. 4. Feagan BG, Choquette D, Ghosh S, Gladman DD, Ho V, Meibohm B, et al. The challenge of indication extrapolation for infliximab biosimilars. Biologicals. 2014;42(4):177–83.
B. Meibohm 5. Othman AA, Tran JQ, Tang MT, Dutta S. Population pharmacokinetics of daclizumab high-yield process in healthy volunteers: integrated analysis of intravenous and subcutaneous, single- and multiple-dose administration. Clin Pharmacokinet. 2014. doi:10. 1007/s40262-014-0159-9. 6. Yamane-Ohnuki N, Satoh M. Production of therapeutic antibodies with controlled fucosylation. MAbs. 2009;1(3):230–6. 7. Hartman TE, Sauer PW, Burky JE, Wesson MC, Huang PY, Robinson TJ, et al., inventors. DAC HYP compositions and methods. US patent US 2012/0301429 A1. 29 Nov 2012.
Protein engineering: a new frontier for biological therapeutics.
Genome engineering for improved recombinant protein expression in Escherichia coli.
Two-stage chromatographic separation of aggregates for monoclonal antibody therapeutics.
An improved fast photochemical oxidation of proteins (FPOP) platform for protein therapeutics.
Aggregation Kinetics for IgG1-Based Monoclonal Antibody Therapeutics.
Building better monoclonal antibody-based therapeutics.
Biodegradable polyphosphazene biomaterials for tissue engineering and delivery of therapeutics.
Monoclonal antibody therapeutics as potential interferences on protein electrophoresis and immunofixation.
Protein engineering of the antitumor enzyme PpADI for improved thermal resistance.
Performance metrics for evaluating system suitability in liquid chromatography--Mass spectrometry peptide mass mapping of protein therapeutics and monoclonal antibodies.
Improved Functional Characteristics of Whey Protein Hydrolysates in Food Industry.
A comparison of protein A chromatographic stationary phases: performance characteristics for monoclonal antibody purification.
Engineering peptide therapeutics using MIMETIBODY™ technology.
Engineering of global regulator cAMP receptor protein (CRP) in Escherichia coli for improved lycopene production.
PPARγ signaling and emerging opportunities for improved therapeutics.
Network biology in development of monoclonal antibody therapeutics.
Transposon for protein engineering.
Improving monoclonal antibody selection and engineering using measurements of colloidal protein interactions.
Monoclonal Antibody Complexes for Control of Established Tumors.
Non-protein therapeutics.
Improving lithium therapeutics by crystal engineering of novel ionic cocrystals.
Newly established monoclonal antibody diagnostic assays for Schistosoma mansoni direct detection in areas of low endemicity.
Applicability of predictive toxicology methods for monoclonal antibody therapeutics: status Quo and scope.
Exploring the potential of monoclonal antibody therapeutics for HIV-1 eradication.
New Methods in Tissue Engineering: Improved Models for Viral Infection.
Re-Engineering Extracellular Vesicles as Smart Nanoscale Therapeutics.
Polyclonal Immunoassay.
Grain boundary engineering for improved thin silicon photovoltaics.
Biomaterials and emerging anticancer therapeutics: engineering the microenvironment.
Circular dichroism spectroscopy as a tool for monitoring aggregation in monoclonal antibody therapeutics.
Protein engineering for improved pharmacologic characteristics of established monoclonal antibody-based therapeutics.
Protein engineering for improved pharmacologic characteristics of established monoclonal antibody-based therapeutics. - PDF Download Free
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Protein engineering holds the potential to transform the metabolic drug landscape through the development of smart, stimulusresponsive drug systems. Protein therapeutics are a rapidly expanding segment of Food and Drug Administration approved drugs t
A metabolic engineering perspective which views recombinant protein expression as a multistep pathway allows us to move beyond vector design and identify the downstream rate limiting steps in expression. In E.coli these are typically at the translati
Aggregates of monoclonal antibody (mAb) therapeutics, due to their perceived impact on immunogenicity, are recognized as a critical quality attribute by the regulatory authorities as well as the industry. Hence, removal of aggregates is a key objecti
Unlike small-molecule drugs, the size and dynamics of protein therapeutics challenge existing methods for assessing their high order structures (HOS). To extend fast photochemical oxidation of proteins (FPOP) to protein therapeutics, we modified its
Monoclonal antibodies (mAbs) as a class of therapeutic molecules are finding an increasing demand in the biotechnology industry for the treatment of diseases like cancer and multiple sclerosis. A key challenge associated to successful commercializati
For 20 years, monoclonal antibodies (mAbs) have been a standard component of cancer therapy, but there is still much room for improvement. Efforts continue to build better cancer therapeutics based on mAbs. Anticancer mAbs function through various me
Degradable biomaterials continue to play a major role in tissue engineering and regenerative medicine as well as for delivering therapeutic agents. Although the chemistry of polyphosphazenes has been studied extensively, a systematic review of their
The use of therapeutic recombinant monoclonal antibodies (mAbs) has triggered concerns of mis-diagnosis of a plasma cell dyscrasia in treated patients. The purpose of this study is to determine if infliximab (INF), adalimumab (ADA), eculizumab (ECU),
Arginine deiminase (ADI, EC 3.5.3.6) is a potential antitumor drug for the treatment of arginine-auxotrophic tumors such as hepatocellular carcinomas (HCCs) and melanomas. Studies in human lymphatic leukemia cell lines have confirmed the anti-angioge
The use of liquid chromatography--mass spectrometry (LC-MS) for the characterization of proteins can provide a plethora of information related to their structure, including amino acid sequence determination and analysis of posttranslational modificat
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Wimproz is a very useful little piece of software that lets you calculate how the wimps offers compare to market price. Once you download it and unzip it, be sure to download the market prices for your server (English server 1, 2, 3, or 4). The next time you get a visit from a wimp (customer), copy it into wimproz, which will let you know how many points this offer is worth and also calculates the percentage from market price (e.g. 85% of market price). It also takes into account the market commission. Try it - its very simple to use.
The current version of WimProz can be downloaded here (.zip, 40K).
Brilliant !!! I'm glad it was helpful !!


When the Great Vegas Festival of Beer kicked off in 2001 at Tivoli Village, it surprised everyone at the last minute by selling out 2,000 tickets, a staggering 90 percent of them in same-day sales.
When the Great Vegas Festival of Beer kicked off in 2001 at Tivoli Village, it surprised everyone at the last minute by selling out 2,000 tickets, a staggering 90 percent of them in same-day sales. Today, it's one of the top beer festivals in a town that has quite a few. Friday and Saturday, it will set up shop downtown — although weather concerns have forced it to move into the World Market Center rather than taking place on the streets of downtown Las Vegas.
Attendees will still get to experience over 500 beers from about 100 breweries. Moreover, it will still offer what founder Brian Chapin says sets it apart from the growing roster of local beer events.
Take, for example, Friday's Mad Craft Experience, a competition and food pairing featuring over 30 creations from mostly local or regional brewers. They'll compete with experimental beer offerings in four categories: Best Beer Blend, Best Beer Cocktail, Best Specialty Beer and Best Beer Experiment. A panel of local judges will select winners.
Restaurants getting in on the action include Other Mama, Vege-Nation, Toddy Shop, Metro Pizza and the Strip Cheeze truck, among others.
The Grand Tasting on Saturday will also have plenty of Las Vegas flavor. Ellis Island casino and brewery will re-create its famed karaoke experience on the premises. PKWY Tavern will run free shuttle service to and from the festival from its three locations, and provide after-parties for those who aren't ready to call it a day when the festival winds down. And Zappos will run a "pretzel jewelry store" to raise money for charity.
Sure, the additional perks are great, but Great Vegas will always be about giving everyone a chance to learn something new about beer, regardless of their experience level.
If you want a formal education, you can check out BrewLogic, a brand-new educational program from master brewers, certified cicerones, industry pros and other experts. Or you can skip that fancy book learnin' and learn by doing — or in this case, drinking.
For ticket info, head to GreatVegasBeer.com.
Contact Al Mancini at amancini@reviewjournal.com or 702-387-5250. Follow @AlManciniVegas on Twitter.


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Surprise finding in response to nipple stimulation
April 21, 2018 Jesus Christ, Nipples, Sex, Women
From a CBS article
Researchers at Rutgers University have mapped the brain areas in women that respond to stimulation of the genitals
WILEY PUBLISHING/BARRY KOMISARUK
For many women, nipples are erogenous zones. A new study may explain why: The sensation from the nipples travels to the same part of the brain as sensations from the vagina, clitoris and cervix.
The study, published online July 28 in the Journal of Sexual Medicine, is the first to map the female genitals onto the sensory portion of the brain. Using functional magnetic resonance imaging (fMRI), researchers noted which brain areas become active when women touch various parts of their bodies. The genital-sensing brain areas in women roughly correspond to the same areas in men, but the nipple finding was a surprise, said study researcher Barry Komisaruk, a psychologist at Rutgers University.
"My speculation is that this could be the basis for many women saying that nipple stimulation is erotogenic, because it stimulates the same area as the genitals," Komisaruk told LiveScience.
Four major nerves bring signals from women's genitals to their brains, Komisaruk said. The pudendal nerve connects the clitoris, the pelvic nerve carries signals from the vagina, the hypogastric nerve connects with the cervix and uterus, and the vagus nerve travels from the cervix and uterus without passing through the spinal cord (making it possible for some women to achieve orgasm even though they have had complete spinal cord injuries).
Experimenters had mapped the male genital senses onto an area of the brain called the medial paracentral lobule, which sits in the crevice between the two brain hemispheres. (If you imagine wearing earmuffs, the medial paracentral lobule would be on the top of your head, right under the band of the earmuffs.) What was missing, Komisaruk said, was a study tracing those four nerves to where in the brain they send their signals.
For their study the researchers recruited 11 healthy, non-pregnant women ages 23 to 56. While inside the brain scanner, each woman stimulated her clitoris, vagina, cervix and nipple by tapping rhythmically with a finger or, in the case of the vagina and cervix, using a plastic dildo.
Nipple mystery
The resulting brain images showed a nexus of activation in the medial paracentral lobule, just as in men. Each area of the genitals showed up in its own spot within this brain region, Komisaruk said. [See the brain images ]
"Even though they're all clustered there like a cluster of grapes, the response to each [genital area] is different," he said. "They overlap, but they're separable."
Nipple stimulation showed up in the area of the brain that receives chest sensations, but it also popped up alongside the genital sensations in the medial paracentral lobule, the researchers found. There could be two reasons for this, Komisaruk said. One is indirect: Stimulating the nipples, as in breast-feeding, releases the hormone oxytocin. This hormone, which is also released during labor, triggers uterus contractions. So it's possible, Komisaruk said, that nipple stimulation triggers uterine contractions, which then produce a sensation in the genital area of the brain.
However, preliminary data suggest that nipple nerves may directly link up with the brain, skipping the uterine middleman. A few men who have been studied show the same pattern of nipple stimulation activating genital brain regions, Komisaruk said. One of his graduate students is further testing the idea by studying the response of women who have had a hysterectomy, meaning their uterus has been removed.
The erotic brain
The women in the study (each of whom was paid $100 to participate) were not necessarily turned on by the self-stimulation in the fMRI scanner; even so, using a similar setup in an earlier study, Komisaruk and his colleagues were the first to locate the female orgasm in the brain.
That leaves the question of what makes a sensation erotic, Komisaruk said.
"Are there particular brain regions that have to be activated in order for genital stimulation to be converted from run-of-the-mill stimulation versus stimulation with an erotic quality?" he said. "That is the big question."
For the record, while eroticism is a mystery, Komisaruk and his lab team found that an orgasm involves a variety of brain regions, including the hypothalamic paraventricular nucleus; amygdala; accumbens-bed nucleus of the stria terminalis-preoptic area; hippocampus; basal ganglia; cerebellum; the anterior cingulate, insular, parietal and frontal cortices; and the lower brainstem.
Komisaruk hopes his research will help people who can't reach orgasm. More broadly, he wants to find out if people can learn to control their brain activity directly, much as we take for granted our ability to move our fingers and toes."If we can control a part of the brain that produces pleasurable sensation, what would that do in the case of, say, depression or anxiety or addiction or obesity?" Komisaruk said. "We really don't know what the limits are as far as what we can make our brains do."

redpajama_set_name: RedPajamaCommonCrawl


The physical environments of high-latitude systems are rapidly changing. For example, the Chukchi Sea has experienced increased water temperatures, advection from the Bering Sea, declines in sea-ice concentration, earlier spring ice retreat, and delayed fall ice formation. This physical restructuring is expected to impact ecosystem structure and function. In this study, a series of bio-oceanographic research surveys were conducted in the summers of 2010, 2011, and 2012 to characterize the physical environment and to examine the influence of physical forcing on zooplankton community distribution and abundance. Results revealed yearly advection from the Bering Sea influenced zooplankton community structure, but this influence became less apparent in the northeastern Chukchi due to changes in current speeds and patterns. Decreased advection and later ice retreat in colder years resulted in zooplankton communities that exhibited more diversity, had higher abundances of the lipid-rich copepod Calanus glacialis, and were less closely related to water masses advected from the south. These findings suggest more localized processes are influencing zooplankton community structure in the Chukchi Sea. Increased inflow of water into the Chukchi is predicted with increased warming in the Arctic and changes in food-web structure and function are likely to result.
The authors would like to thank Captian Atle Remme, F/V Alaskan Enterprise, Captian Fred Roman, F/V Mystery Bay, and Captain Kale Garcia, R/V Aquila, as well as all crewmembers. Special thanks also go to Catherine Berchok for her excellent leadership; Jeannette Gann and Esther Goldstein for taking the time to review the manuscript; Rebecca Woodgate for suggestions and sharing physical data; the Bering Strait mooring project; Sigrid Salo for help with ice data; Kathy Mier for data analysis tips; Polish Sorting Center for their hard work with zooplankton samples; and North Pacific Climate Regimes and Ecosystem Productivity (NPCREP) program for support. This research was part of the Chukchi Sea Acoustics, Oceanography and Zooplankton (CHAOZ) study that was funded by the Bureau of Ocean Energy Management (BOEM; Contract No. M09PG0016).
The authors declare that there is no conflict of interest in presenting this information.


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Q: Storing fields from a JSON object in ASP.NET 3.5 I am calling an external web service (Facebook API) which returns a JSON object (see below) in the code behind of one of my pages. I am trying to figure out the most efficient way to store each of the fields from this JSON object in my code-behind (actually trying to get one field, the amount field). The JSON object is as follows:
{"algorithm":"HMAC-SHA256","amount":"5.00","currency":"USD",
 "issued_at":81723498712,"payment_id":71283749753874,"quantity":"5",
 "status":"completed"}

I simply want to grab each variable (or the one I need), store it in a variable (string, int, etc.), then use it for whatever I need to in my code-behind. Also, note that I am using ASP.NET 3.5 / C#.
Any advise on this would be helpful.  Thanks in advance for your help!

A: You can use Newtonsoft's Json.NET library. It's very simple to use. You can install it with NuGet packages in your MSVS or just download from the website http://json.codeplex.com/
Then you should create class like this:
class FacebookResponse
{
    public string Algorithm {get;set;}
    public float Amount {get;set;}
    public string Currency {get;set;}
    public DateTime IssuedAt {get;set;}
    public string PaymentId {get;set;}
    public int Quantity {get; set;}
    public string Status {get;set;}
}

After that, when you recieved your JsonString from API, you can use following method:
FacebookResponse response = JsonConvert.DeserializeObject<FacebookResponse>(JsonString);

And if you need to serialize that class, using JSON, you can use:
var facebookResponseItem = new FacebookResponse();
//some initial code here
var sendFacebookResponseItem = JsonConvert.SerializeObject(facebookResponseItem);

A: I figured it out, code is below:
var result = "Code for Call to Facebook Goes Here - Returns JSON Object";
string json = result.ToString();
var serializer = new JavaScriptSerializer();
Dictionary<string, string> values = serializer.Deserialize<Dictionary<string, string>>(json);
string amount = (string)values["amount"];

A:     class Item{
      public string algorithm {get;set;}
      public float amount {get;set;}
      public string currency {get;set;}
      public Date issued_at {get;set;}
      public string payment_id {get;set;}
      public int quantity {get; set;}
      public string status {get;set;}

    }

   Item item = JSON.Deserialaize(JSON_OBJECT)  // check for specific syntax
   Item[] item = JSON.Deserialize(JSON_OBJECT) // even can get array of json objects

You can now use these json object in what ever way you want.

redpajama_set_name: RedPajamaStackExchange


text:
Q: Clear fields from a dynamic form in AngularJS here is my angularjs code:

function addController($scope, $http) {
  $scope.update = [];
  $scope.properties = [];

  $scope.addProperties = function(property) {
    $scope.properties.push({});
  }
  $scope.add = function() {
    $scope.update.push({
      "tableName": $scope.tableName,
      "name": $scope.name,
      "properties": $scope.properties
    });
    $scope.tableName = undefined;
    $scope.name = undefined;

  }

}
<!DOCTYPE html>

  <title></title>
  <meta charset="utf-8" />

  <link rel="stylesheet" href="http://maxcdn.bootstrapcdn.com/bootstrap/3.2.0/css/bootstrap.min.css">

    TableName:
    <input type="text" class="form-control" ng-model="tableName" />

    Name:
    <input type="text" class="form-control" ng-model="name" />

    Properties:
    <fieldset ng-repeat="property in properties track by $index">
      Column Name:
      <input type="text" class="form-control" ng-model="property.columnName" />

      Name:
      <input type="text" class="form-control" ng-model="property.name" />

    </fieldset>
    <button class="btn btn-default" ng-click="addProperties()">Add Properties</button>

    <input type="submit" ng-click="add()" />

{{update[0]|json}}

Here ColumnName and name are dynamic textboxes added by click of addProperties button.
My problem is in add() function. once the form elements are pushed to update(array) i want form elements to be cleared.
tableName and name were assigned to undefined since they are not dynamic and works fine. can you help me in assigning columnName and name fields to null or undefined.(special note: assigning to null or undefined must only affect the view. values pushed inside the update array must not change)

A: Update your addProperties method to this.
    $scope.addProperties = function (property) {
        $scope.properties.push(property);
        $scope.property = {name:"", columnName:""}
    }

That will reset the property in the view, i'd also not use an ng repeat on the props in your view so you will only have one set of inputs to edit.

A: You should clean your property object after pushing:
$scope.addProperties = function(property) {
    $scope.properties.push(property);
    property = {"name": null, "columnName": null};
}

Note: Avoid using undefined to clean object as it said the property is... not defined!


Used Commercial boat Commercial Crew Boat N.3 for sale located in 0,Italy,Italy, founded in 1980. The manufacturer of boat - unknown. It`s overall length is 30.42 meters. Width of boat is 6.57 meters. Engine uses fuel. You can buy Commercial Crew Boat N.3 just for 400000 EUR.
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Ducati Manchester is able to offer the best deals on new and used Ducati motorcycles in the UK. Because we are the UK's first Ducati Store we have purchasing power to offer you the lowest finance rates and affordable options on the entire Ducati range.
Give us a call today for latest special offers and finance rates.
In partnership with Black Horse Finance and Ducati UK, Ducati Manchester are pleased to offer TriOptions Finance - an affordable option to own your new Ducati.
Ducati has constantly reacted to customer needs by not only producing market challenging products but also by making our motorcycles more affordable. This has been done by reducing service costs, extending service intervals and by offering a range of Ducati finance options that make the dream of owning a Ducati a reality - Ducati TriOptions Finance, a Personal Contract Plan.
Low Monthly repayments. Using this form of finance the monthly payments (and deposit) are lower than regular finance as the residual value in a Ducati is generally one of the highest in the Industry. The residual value value is used to offset monthly payments, keeping them low when compared against regular finance.
Ride a new Ducati every two to three years.
TriOptions is designed to meet the customer's budget by helping them set the amount of the regular payments based on their proposed annual mileage. Customers are then in a position to finance a newer more affordable Ducati or part exchange* it for a new one every two to three years if they so wish.
Those buying a Ducati can choose their likely annual mileage and, dependent on term and mileage, Ducati Finance will calculate the Guaranteed Future Value of their bike at the end of the agreement which will reflect in the monthly payments. Ducati's residual values are amongst the strongest in the industry.
The customer can set repayment periods, then take the best option for them when they reach the end - part exchange* it with the Ducati dealer for a new one, buy it outright at the pre-agreed price or return the Ducati to the Ducati dealer.
For those motorcyclists that want to ride the newest Ducati and be able to keep their options and be able to budget to achieve their motorcycling dream, then TriOptions is the only option to make the desirable affordable.


text:
Armenia Adopts Universal Inclusive Education in Preschools
Education authorities say 2021 will see "significant work" in the direction of introducing universal inclusive education system in Armenian presc...
mayo 11th 2021
20 escuelas de la zona rural de Armenia reciben bienes tecnológicos de la comunidad armenia de los Países Bajos
According to the official Facebook page of the High Commissioner for Diaspora Affairs of the Republic of Armenia, the Dutch-Armenian community, l...
abril 13th 2021
La Escuela de Medicina de la UNLV llevará el nombre de Kirk Kerkorian
The Las Vegas Sun announced earlier this week that the University of Nevada, Las Vegas School of Medicine will be named after Armenian-American m...


text:
Events / Family / Health and Fitness / Lifestyle / News
Reebok Canada Partners with Public Health Agency of Canada and Canadian Football League to Provide BOKS to Elementary School Students in Canada
by James Chung · Published November 25, 2014 · Updated November 25, 2014
Reebok Canada announces a partnership with the Public Health Agency of Canada and the Canadian Football League (CFL) to expand and enhance physical activity in Canadian elementary schools through BOKS (Build Our Kids' Success). With a goal to enlist more than 450 schools in the next five years, BOKS, a free morning physical activity program, will launch in 10 schools this September, serving more than 400 kids in kindergarten through fifth grade. An initiative of Reebok and the Reebok Canada Fitness Foundation, BOKS is designed to get kids' bodies moving in the morning and their brains ready for a day of learning.
BOKS aims to help improve kids' academic performance and overall health through physical activity and nutritional knowledge. The program reinforces the Public Health Agency of Canada's commitment to help all students meet the medically recommended goal of 60 minutes of physical activity every day. As part of the agreement, the Public Health Agency of Canada is providing funding that will go to hiring and training BOKS staff, marketing, promotion, research and start-up equipment for schools throughout Canada.
"The BOKS program is an exciting way for younger Canadians to increase their physically activity levels, while also boosting their positive mental and social health so that they are more confident and ready to learn when the school day begins," said The Honourable Rona Ambrose, Minister of Health. "We are proud to be working with Reebok and the CFL to bring this program to Canada. Innovative partnerships like this are an excellent example of how all sectors of society are working together to help our children and youth adopt active and healthy lifestyles."
Additionally, the CFL, which has been actively involved in Canadian communities throughout its rich history, will help raise awareness of BOKS. The CFL will provide marketing support ranging from digital, social and in-stadium assets and activations. Additionally, its players will make visits to participating schools to help students live a healthy lifestyle and excite them to get active.
"The health and wellness of our youth is an important issue facing our country today," said CFL Commissioner Mark Cohon. "The game of football and sports in general can play an important role in promoting physical activity in children. We are proud to partner with Reebok on this very important initiative and look forward to our teams and players being involved in getting our young Canadians physically active and having fun. Together, we can have a real positive impact on our youth in our communities."
BOKS was started by Kathleen Tullie and a group of moms in 2009 who were inspired by Dr. John Ratey's book Spark, which provides compelling evidence that physical activity will supercharge mental circuits to beat stress, sharpen thinking and enhance memory in kids. Run by community volunteers, including moms, dads, teachers and anyone passionate about getting kids active, BOKS provides free training, curriculum and support for those interested in bringing the program to their school. BOKS is a 45-minute session and runs a minimum of twice a week at school. A typical BOKS class includes warm up, a running related activity, skill of the week (i.e sit-ups), a fun game, a cool down period and a BOKS nutritional bit before the students are transitioned off to their classes. Kathleen Tullie, states unequivocally that the reason for the program's success is a perfect combination of passion from parents, educators and school staff that have the motivation to make a difference in children's lives.
"We are very proud to launch the BOKS program in Canada and couldn't be more pleased with our partnerships with the Public Health Agency of Canada and the Canadian Football League," says Michael Rossi, President of the adidas Group Canada, parent company of Reebok Canada. "The potential for growth throughout the country is endless. With the support of our partners, we plan to bring BOKS to as many schools as possible, empowering kids, staff, and entire communities to make physical activity a part of their daily routines for life."
"We are extremely excited to launch BOKS in Canada, especially as we continue to expand worldwide," said Kathleen Tullie, BOKS founder and director of social responsibility Reebok U.S. "The implementation of BOKS represents Canada's commitment to helping kids live a healthier lifestyle. BOKS can have a positive impact on classroom performance, behaviour and overall health, and the opportunity for growth in Canada is tremendous. Collectively we need to take action and reverse the physical inactivity epidemic we are currently experiencing."
For more information about BOKS, visit www.bokskids.org, the BOKS Facebook page or the BOKS Twitter handle.
We have partnered up with Reebok Canada to give away 2 tickets to the 102nd Grey Cup this Sunday, November 23rd!
Tags: BCBOKSBritish ColumbiaCanadaCanadian Football LeagueElementary School StudentsLower MainlandMetro VancouverPublic Health AgencyReebok CanadaVancouver
James Chung
Founder & Editor in Chief of Hello Vancity magazine. Email james@hellovancity.com
bekki says:
Calgary will win
Aaron B. says:
Would love to take my wife to this!!!
Calgary is going to win!!!!
Helisa Duplassie says:
Cheering for Hamilton! Since my Lions aren't in it and I'm originally from Ontario :)
Tara Jensen says:
Oooh… I want to say Calgary.. but I'm not 100% sure this time! lol
@TheContestadore says:
Hamilton wants it more.
Shannon Grochowski says:
Cheering for Calgary!
Christopher Co says:
Calgary!
Ticats
angela mitchell says:
Ei-Leen Ong says:


The competitive race started in Stirling and ended in Stirling 620kms later. The teams made up of four people to include a least one female were from all over the world. They had to mountain bike, canoe, orienteer, or run on different stages. Teams started to arrive at House of Mark from 02.00 on Wednesday and were still arriving after 21.00, these teams being the premier teams who chose to take a harder lengthier route. A busy day!
House of Mark fed and watered the teams and helped the transition to the next stage a mere 105 kms run. The event organised by Open Adventure's team and workaholic enthusiasts will be shown on channel 4 in the near future.
The whole race is an eye opener for any would be Mr and Mrs Fit who thinks a triathlon is easy.


text:
Governor Visits Seguin To Mark Caterpillar Milestone
Almost 10 years ago, Caterpillar broke ground in Seguin and began building a new engine manufacturing facility.
The company rolled out its 400,000th engine at the plant, which received its final inspection signature from Texas Gov. Greg Abbott.
"We did get to recognize a landmark with the 400,000th engine that is being shipped from this facility," Abbott said during a special ceremony at the plant. "That is something everybody here should be proud of, but very importantly this a tangible result of the hard work that you and your fellow workers put in. It is a landmark that you should be very, very proud of."
Caterpillar Inc. group president Ramin Younessi thanked Abbott for helping to celebrate the milestone.
"On behalf of Caterpillar, I would like to sincerely thank our governor," he said. "We have a very proud group of about 2,500 folks in our four manufacturing plants in their area. I wanted to be here today to see the impressive line of operations that you have, to get to have officially signed the 400,000th engine manufactured by Caterpillar, but most importantly to thank you for the role you play in a very dynamic economy helping to lead the way, making sure Texas remains the number one state in the United States for doing business."
Continue to full article
Why are Foreign Trade Zones Making a Comeback?


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redpajama_set_name: RedPajamaGithub


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Find & Compare
Mellor International
Aftersales & Warranty
Mellor Coachcraft
Two all-new versions of successful Strata bus released
By Rachael Buckley
Mellor makes a splash with a double debut at Euro Bus Expo 2018
Leader in small bus innovation Mellor has launched two new and revolutionary products at Euro Bus Expo this year.
The new Strata Plus and Strata Ultra were unveiled at the National Exhibition Centre on Tuesday 30 October. They follow on from the success of Strata, which Mellor developed to be 'the UK's small bus of choice'.
These new models combine the rigorously tested Mellor coach-built body and low frame conversion with the proven Mercedes Benz Sprinter chassis and drivetrain. They also feature the Strata's class leading fuel economy and low cost of ownership. The innovative low floor saloon area easily accommodates wheelchair or buggy users, while creating accessible and spacious seating areas.
Strata Plus will immediately benefit from LEB accreditation, further reducing operating costs. It is anticipated that LEB accreditation of the Strata Ultra will follow in early 2019. Operators will also receive a comprehensive three-year warranty support from Mellor.
Both new buses have extended wheelbases and body lengths and will be offered on the new model 907 Mercedes Sprinter. The Strata Plus reaches 8.1m and the Ultra stretches to 8.8m. They have accessible low floor single-step entry and are the same width as the original Strata model.
Strata Plus and Strata Ultra accommodate 26 and 30 passengers respectively, giving operators the opportunity to increase vehicle-carrying capacity while still enjoying the efficiencies, economies and advantages delivered by a small bus.
Mellor managing director John Randerson said: "We are extremely proud that all Mellor low floor buses have class-leading seated capacity. We believe passengers will have an enhanced experience and that travelling in comfort will lead to increased bus patronage and route viability.
"We actively encourage the engagement of our sales and engineering teams with our customers to ensure vehicles are tailored to meet their requirements."
An array of features are available to enhance operator and passenger experience, including destination signage, interactive next stop audio-visual displays, climatic control, Wi-Fi connectivity and USB charging points.
The ground-breaking design characteristics of the Strata are continued in the Strata Plus and Ultra, ensuring that space for seated passengers is prioritised.
Highly customisable, the vehicles also come with a range of additional options to meet varying accessibility and executive demands. Choices of seats, interior trim levels and designs are available across the range.
The Strata Plus and Ultra exemplify Mellor's commitment to the small bus sector, and the belief that bus services can be provided cost-effectively.
John Randerson added: "We invested extensively during the Strata's initial development phase. This has been justified since its introduction with excellent customer feedback and significant numbers of vehicles already delivered and in service. As part of our continued growth strategy and as a result of customer requests, we challenged ourselves further to provide a higher carrying capacity on what is acknowledged to be an excellent platform. I think we can all be proud of the result."
Award winning East Lothian bus company chooses Mellor
Prentice Coaches of Haddington has taken delivery of a new Mellor Strata low floor bus as...
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Mellor Orion E keeps rural H.A.R.T. beating
Mellor's next generation of the Orion E electric bus is set to star at The Commercial Vehicle Show
Stringers Coaches is first to order new Strata Ultra
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It's harvest time on the Naramata Bench and Square One Hops is an anomaly where it's vines, pears and apples being harvested. The only hopyard on The Bench makes an interesting photo essay subject.
The bines are cut from the trellising and a tug-of-war ensues.
The bines grow to a Jack-and-the-beanstalk towering height before harvest.
The aromas in the hopyard are a wonderful mixture of citrus, herbal, piney, spicy, garlic, onion, grassy and tobacco. Each step I take on left-behind hops and bines releases these subtle yet heady IPA scents.
A season's worth of growth is astounding.
Part of the crew cutting the bases of the bines. This perennial plant will tower again next year.
It's a science to determine when the hops are at their hoppy best.
Smoke from area wildfires makes for some moody photographs.
Feeding the beast. The hops harvester is a beautiful thing as many small operators pick the hops off the bines by hand.
Brian Tarasoff, who along with wife Kari, own and operate the two-acre Square One Hops operation in Penticton, is in his element and covered in hops.
The hops will then be dried and most pelletized.
Hops pellets are preferred for use by many brewers.
Perfectly ripe hops awaiting the crew and ultimately the brewmaster.


text:
A Game Design Document can be an invaluable tool for hypercasual studios | Pocket Gamer.biz
Tom Pigott is CEO and founder of Ludo.ai, and founder of Jetplay
The hypercasual genre remains, by some distance, the largest of its kind within the gaming industry. Around 40 per cent of all games are classified as hypercasual, and 45 per cent of all mobile gaming downloads fall within the hypercasual genre. So it is important that hypercasual studios are as up to date as possible when developing their next product.
Hypercasual games are defined by multiple characteristics, and fundamentally involve straightforward mechanics and design, low difficulty levels, and quick and easy gameplay. But this straightforward appeal does not mean simple design, and studios need to do everything they can to ensure their games are as appealing and accessible as possible.
The design and development process is crucial when creating hypercasual games, and a well-formulated Game Design Document (GDD) is an invaluable tool that is collaborative and encourages innovation, regardless of the expected life cycle of any title.
GDDs create one collaborative space
A GDD is a useful tool for studios looking to work quickly and efficiently. It provides the foundation for a gaming project, breaking down the key elements of the development process in one collaborative space.
A GDD is a useful tool for studios looking to work quickly and efficiently
Tom Pigott
It can also act as a blueprint for the design and mechanics of the game. For hypercasual studios, the collaborative nature of a GDD can be really important. Agreeing on a plan with members of their team from the very beginning of the project, and ensuring that the process has a clear structure from the outset, can be key to the success of the game development process.
This is made all the more important given the high turnover of titles within the hypercasual space. A GDD can make developing a game a smoother and more efficient process.
Embrace new tools
SIFOR studios, an indie hypercasual game studio which uses cutting-edge AI tools to develop highly successful hypercasual mobile games, spoke to how effective a GDD can be in helping these studios thrive in such a competitive section of the industry.
Ali Hamwi, CEO and co-founder of SIFOR, stated that "a process that was previously taking days now takes seconds," through the use of a GDD and other tools within it, He also stated that the use of these new tools has seen SIFOR accelerate its development process, allowing them to create over 50 games in the last year alone.
While studios operating within other genres may use a GDD to keep track of a game development process, hypercasual studios games can showcase GDDs other benefits. Within the hypercasual space, a well-built GDD can provide a structured plan that studios can follow, or even establish a template that can be used again and again.
What this means for studios, and what was definitely the case for SIFOR, is using new tools to create a GDD can result in a higher turnover of games, helping studios compete in what is already a very populated industry.
A GDD constantly evolves: ideal for the time constraints hypercasual studios face
One of the features of a successful GDD is its brevity and flexibility. Hypercasual studios in particular are often faced with time constraints, and competition in the mobile games sector can put studios under pressure to turn over a lot of titles in a very short period of time. A GDD can be a very straightforward and short document that is invaluable to studios whose time is precious.
Jelly Jump
Hamwi again outlines this implicitly, stating: "Time is an incredibly important currency, and how that time is used and shared among team members is key." For this reason, the constantly evolving nature of a GDD can really help studios. A successful GDD evolves alongside the game, changing quickly as the game development progresses. It can also make the process more flexible, meaning changes can be made quickly and efficiently in line with shifts during the process.
Stick to the core, but with room to grow
Flexibility is important when creating a GDD. It has the game concept at its centre but is also able to adapt and change as development progresses. This flexibility is important to hypercasual studios that might be producing a large number of games in a short time.
A flexible GDD means these studios may make significant changes to the concept and design of a game quickly while keeping other members of the team up to date.
One of the many ways studios can look to effectively utilise a GDD is by creating a base GDD template which lays the foundations of their development process. Once they have this working template locked in, it can be easier for studios to adapt and evolve the key elements of each project they do.
What to include in your GDD
We have now established why a GDD can be such an important tool for hypercasual studios, but what should studios look to include in their own GDD?
A summary of the game concept
A key feature of hypercasual games is that they are able to provide an entertaining experience for players with a combination of regular positive results, easy to achieve in-game incentives, and effortless repetitive play.
This is often achieved by having a sound game concept, something a GDD can help to establish. Many studios elect to establish a summary of their concept at the beginning of their GDD. This describes the game in concise detail before setting out the project plan and the schedule the team will look to follow. It can also outline the target audience for the game, whilst hypercasual studios may decide to include the specific type of hypercasual game they are planning to produce.
Clearly defined key elements of the game
A GDD can also be divided into separate sections that address the key elements of the game's design, gameplay and mechanics. Hypercasual studios are constantly striving to streamline their development process in order to meet the high demand for hypercasual mobile games in the marketplace.
Giant Rush!
A GDD which is clearly structured into sections can help in this pursuit of productivity. Many studios may choose to divide elements such as game mechanics, design, and audio into separate sections.
Much as hypercasual games may rely heavily on relatively simple graphics, mechanics and design, it can still be incredibly useful to organise these elements into clearly defined sections, allowing them to narrow their focus and lock in what is best for their game concept.
Up to date information on the development process
A GDD should be kept up to date, whether significant changes have occurred in the game's development or not. However big or small these changes may be – from changes to the core fundamentals of the game to the team members working on it and the development schedule itself – they should be recognised and reflected in the project's GDD.
This is not necessarily crucial to the success of the game itself, but it can make the development process far more productive
Some studios may decide to keep hold of earlier versions of their GDD in order to evaluate their process at the end of a project. It is crucial that during the process itself every member of the team is working from the same, up to date edition of the GDD.
A dynamic and engaging aesthetic
Studios should try to make a GDD visually interesting and dynamic. This is not necessarily crucial to the success of the game itself, but it can make the development process far more productive. Teams are proven to work more efficiently when the materials they are working with are engaging, and a game development team is no different when working with a GDD. A visually exciting GDD may also inspire new and interesting ideas that may ultimately inform the finished product.
To recap, here are my key points on why GDDs are invaluable to hypercasual studios:
A GDD is a collaborative document, encouraging innovation and inspiration for studios all in one place
They act as a collaborative hub for teams developing their next game, streamlining the development process by having everything in one place
AI offers new opportunities when creating a GDD
A GDD is a constantly evolving document, which is ideal for the time constraints hypercasual studios face
With time being a precious commodity, and hypercasual game studios needing to appeal to an increasingly large market, the flexibility of a GDD is invaluable
A flexible GDD centre on the core concept of the game, but also allows ideas to grow
Hypercasual mobile games often begin life as a very simple concept, before other elements are added, a process which a flexible GDD can enhance
And these are the key things for studios to include in their GDD:
A short introduction on the type of game the studio is aiming to create
Clearly defined sections pertaining to key elements of the game
These can include design, game mechanics, and gameplay features among others
A GDD should be updated whenever there is a significant development in the game creation process, to ensure everyone is working from an updated version
A successful GDD should look to use dynamic visuals and presentation as this will aid in the engagement of the entire team during the process
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Errol Spence Jr. spars with Brian Custer
Could COVID Increase Your Risk for Shingles?


Your purchased copy may be updated at .
Bug Fix: Fix to Restore dialog for High Sierra. It was not showing the available snapshots to restore from.
This version, and ones back to v1.2.0, work with Final Cut Pro 10.4.5.
Optimization to the Restore process, particularly for archives that are years old.
Bug Fix: On Mac OS El Capitan and Mac OS Sierra systems a quirk was introduced that caused Backups to not recognize volumes that were mounted after the application was launched. This could also happen at startup time if Backups came up before online volumes were fully recognized by the system. This required the user to; either relaunch Backups or to repick a backup source or destination to see them. This has been fixed.
When you quit, if you have defined automatic time interval backups, and these are active, you'll be asked if you really want to quit or just hide the application.
A "Restore" button has been added to individual snapshot listings in the snapshot list. This lets you go right to the Restore dialog to restore to this snapshot. Once there, you can cancel out if you are not interested.
The snapshot list also show "Trim to:" counts so if you want to trim your archive to a given snapshot, you'll know how many snapshots to trim to.
Note in the Filters tab of a backup definition about backing up Motion Templates in FCP 10.3+ libraries.
When snapshots with actual changes complete, it sends notifications to the OS X Notification Center to inform you. Use System Preferences->Notifications to control this feature.
A "Reveal in Finder" magnifying glass in the backup definition dialog lets you find the corresponding .fcpBackups archive.
When doing a Restore, it will not ask you to make sure FCP X is not running, if it is not running.
Will not let you put your archive in Time Machine's folders.
Several consistency checks concerning where you are saving your snapshots.
Small changes to many dialogs and alerts.
Coordinated with the upcoming Backups for iMovie.
Supports FCP X 10.3 libraries. Note: The "Backup 'Motion Templates'" option in Filter tab of backup settings refers to the global templates in your Movies folder. Motion Templates in your FCP X 10.3 libraries are always backed up.
Be able to handle all file systems including Windows file systems. File modify dates are stored separately in a common format so dates compare properly across file systems.
Major new feature—Filters: Control which libraries you want backed up from a folder or volume. Select whether or not to backup new libraries. Option to backup Motion Templates.
A Trim button lets you remove older snapshots from an archive.
Checkbox on the main window to hide "Inactive" backup operations.
Backups will always back up media aliases.
Makes sure backup archives (.fcbBackups files) have a unique name and path for new definitions.
Improvements to the snapshot removal algorithm.
Improvements to the Logging feature.
New kinds of folders to ignore in libraries—"__AsyncCopying" and "__Temp" in FCP 10.2 libraries.
Build numbers are maintained and shown in splash screens as per Apple's request.
Help files have been updated to reflect the new features.
Don't back up or restore "__sync__" files—internal to FCP X libraries.
When defining a new backup operation, start the user off in their "Movies" folder.
Refined text on volume picker dialog as per Apple's request.
Be able to back up and restore projects and events right out of FCP X libraries (.fcpbundle).
Able to search a whole disk or a specific folder looking for libraries. Options to scan subfolders.
Be able to drill down several folder levels when selecting a SAN location.
Bonus Feature—Logging: Backups for FCP will keep a log of the files backed up or restored as well as other operations. You can check the log to see what was actually saved or restored. There is also a log on each snapshot; listing the file changes it recorded in the snapshot.
Improved energy use profile and support of Mavericks App Nap feature.
Bug fix: Not detecting if a folder has come back online.
Added an icon to allow viewing the snapshots list right from the main window. A "Log" button on each snapshot lets you see the actual changes the snapshot recorded.
Tooltips on main window explain what all the buttons do.
"Estimate Backup Size…" shows the number of libraries found.
Analysis Files are now treated like Render Files, they are ignored. Both kinds of files will be regenerated by FCP X automatically when it needs them.
No other changes in functionality.
Initial support for Xsan network locations.
You may now double-click on a .fcpBackups archive to initiate a restore.
You may now control backing up Transcoded Media with an option. Unchecking this can create much smaller backups. Transcoded media may be regenerated from your Original Media.
Show the shortfall if a backup or restore was abandoned because of insufficient disk space.
Not all file system types are supported by FCP X and Backups for Final Cut Pro. We now only let you select volumes and backup folders on file systems that are supported.
Fixed a problem where the root volume was not pickable in "Volumes" folder on some MacOS versions.
As part of running a backup, it deletes a previous temporary backup folder before the space requirement calculation is done. It removes old misspelled, temporary backups.
Support for "Event Manager X" and hidden Projects and Events.
Renamed "Maintenance", "Snapshots" on the backup options sheet.
Show backup progress information, featuring the amount of data it is copying, while performing a backup or restore.
Support for explicitly restoring Color Presets contents. Color Presets as well as Export Presets are currently being back up, and you may implicitly restore them by restoring a whole Final Cut Events folder. Now you may explicitly select Color Presets when doing a restore.
Initial release to the Mac App store.
Fixed various issues with backing up and restoring to network attached drives. Network attached drives do not have a Trash folder, so files must be deleted directly.


And a moment for your soul to mend.
In framing Sonnets in my seat.
Such a tea of Simpson and Vail's.
As good a tea as potpourri!
The color a rich chocolate gold.
This tea we doth surely keep.
Huzzah for a second steep!
Description: Gardens, herbs, and flowers appear in many of Shakespeare's plays and oftentimes play a critical role in his stories. Our William Shakespeare tea blend is a combination of a few of the many herbs he references: lavender, roses, rosemary. The wit and playfulness of his verse means that Shakespeare's plays can still be enjoyed today, ideally with a warm cup of tea.


New programming series curated for 2016 – 2017 season to include Billy Crystal, Smokey Robinson, Bernadette Peters and more.
November 16, 2016 – Orlando, FL – Dr. Phillips Center for the Performing Arts and Morgan Stanley announce their continued partnership for the 2016 – 2017 season with the development of a new series: Morgan Stanley Moments at Dr. Phillips Center, which will launch with the recently announced Spend the Night with Billy Crystal in February. New offerings include Smokey Robinson in March and Bernadette Peters in April. A fourth additional artist to round out the offering will be announced at a later date.
Morgan Stanley was the proud sponsor of the Jazz Series at the arts center for the 2015 – 2016 season. That series boasted memorable performances by iconic artists: Arturo Sandoval, Michael Feinstein, Patti LaBelle and Tony Bennett. In reflecting back on the season, each concert had the following in common: Legendary performances. Unparalleled artistry. Exceptional experiences.
Spend the Night with Billy Crystal, which was recently announced to play Dr. Phillips Center on Wednesday, February 1, 2017, will be the first moment in the series. Tickets for the hilarious and intimate evening of stories from the Tony® and Emmy® Award-winning actor, producer, writer and director go on sale to the public this Friday, November 18, 2016 at 10 a.m. A stand-up comic turned television star, Crystal found fame as a movie funnyman and was much loved as the acclaimed nine-time host of the Academy Awards. He is also an award-winning author, and his latest memoir, "Still Foolin' Em: Where I've Been, Where I'm Going, and Where the Hell are My Keys?" was an instant New York Times best seller.
The next moment in the series will feature Motown legend Smokey Robinson singing favorites from his 50-year career. Once pronounced by Bob Dylan as America's "greatest living poet," the singer-songwriter has received awards spanning from the GRAMMY® Living Legend Award, NARAS Lifetime Achievement Award, Honorary Doctorate (Howard University), Kennedy Center Honors and the National Medal of Arts Award from the President of the United States, and has also been inducted into the Rock 'n' Roll Hall of Fame and Songwriters' Hall of Fame. The dictionary defines the popular term "comfort food" as "food prepared in a traditional style, having a usually nostalgic or sentimental appeal." It has been known to soothe the soul and spur memories of more "comforting" times. With his eternally smooth and instantly recognizable falsetto alone, the legendary Robinson is the audio equivalent of comfort food…comfort food for the soul…with soul. He has accumulated more than 4,000 songs to his credit and continues to thrill sold-out audiences around the world with his voice, impeccable timing and profound sense of lyric. Remaining a beloved icon in our musical heritage, Robinson will take the Walt Disney Theater Stage on Friday, March 3, 2017 at 8 p.m. Tickets start at $55 and go on sale to the general public Friday, December 2, 2016 at 10 a.m.
Bernadette Peters shines as the third moment in the series. Throughout her illustrious career, the three-time Tony, Golden Globe, and two-time GRAMMY Award-winner has dazzled audiences and critics with her performances on stage and television, in concert and on recordings. Now, one of Broadway's most critically acclaimed performers will appear at Dr. Phillips Center in the Walt Disney Theater Friday, April 21, 2017 at 8 p.m. Most recently appearing on stage in City Center's Encores! production of A Bed and a Chair: A New York Love Affair, featuring the music of Stephen Sondheim with orchestrations by Wynton Marsalis, the performer's other stage credits include: A Little Night Music, Song and Dance (Tony and Drama Desk Awards), Annie Get Your Gun (Tony Award), Gypsy, The Goodbye Girl, Sunday in the Park with George, Mack and Mabel, On the Town, and Into the Woods. While best known for her work in the theatre, her career also boasts an impressive list of television credits including "Mozart in the Jungle," "Smash," "Grey's Anatomy" and "Ugly Betty" among others. On the silver screen: "Pennies from Heaven" (Golden Globe Award), "The Jerk," "The Longest Yard," "Silent Movie," "Annie," "Pink Cadillac," "Slaves of New York," "Alice," "Impromptu," "It Runs in the Family" and "Coming Up Roses." Her six solo albums include the GRAMMY-nominated "I'll Be Your Baby Tonight," "Sondheim, Etc.," "Bernadette Peters Live at Carnegie Hall" and "Bernadette Peters Loves Rodgers & Hammerstein." Peters devotes her time and talents to numerous events that benefit Broadway Cares/Equity Fights AIDS, as well as her "pet project," Broadway Barks, which she co-founded with Mary Tyler Moore. She is a New York Times best-selling author, penning three children's books: "Broadway Barks," "Stella is a Star," and "Stella and Charlie: Friends Forever." Tickets start at $55 and go on sale to the general public Friday, December 2, 2016 at 10 a.m.
A fourth artist in the Morgan Stanley Moments at Dr. Phillips Center series will be announced at a later date.
Tickets for all performances may be purchased online at drphillipscenter.org, by calling 844.513.2014 or by visiting the Dr. Phillips Center Box Office at 445 S. Magnolia Avenue, Orlando, FL 32801 between 10 a.m. and 4 p.m. Monday through Friday, or 12 p.m. and 4 p.m. Saturday. Online and phone ticket purchases include handling fees.


As many of our regular readers know, a G4-based Mac mini was my primary computer from March 2005 until August 2008. A few months after I got my MacBook Pro, I decided it was time to put the Mac mini out to pasture. Although many would regard it as a "low-end" model, I put in quite a few hours editing video on Final Cut Express and doing everyday computing tasks (including designing/administering SchwarzTech).
Actually, I stopped using it once I got my data transferred off of it, and it sat unused for most of the last year (in my defense, things were a bit busy and I didn't have time to tinker). About 4 months ago I decided to take it out of its box (yeah, I saved everything) and give it a new lease on life. My "home theater" setup was rather basic at the time — an ancient 27″ SD analog TV, a Sony receiver, a Sony DVD player, a Panasonic DVD recorder, and a Panasonic VCR. The Mac mini connected to this setup with the Apple DVI-to-composite video adapter provided to be quite nice, although a bit blurry. Using a mix of Leopard's Screen Sharing feature and teleport, I had full control of the Mac mini with my MacBook Pro.
This setup worked well for streaming media over the Internet or my MacBook Pro, but that was about it. As it was a first-generation Mac mini, there was no remote or ability to add an official Apple one (why they didn't make remotes Bluetooth-based is beyond me). Fortunately, I was able to pick up an old TV tuner (a Plextor model, similar to the model we reviewed, but a PC model that had EyeTV software added later) from a friend. It only had an analog tuner, so would be useless for over-the-air broadcasts by June, but would work fabulously with my analog cable. I could now use the Mac mini to record my favorite shows that I'd want to save, as opposed to my DVD recorder which was more for a watch-and-delete scenario.
Again, the lack of a remote and "large screen" interface kept the Mac mini from being a major player in my living room, but my TV decided to die at the end of May. I decided to take the plunge and pick up a new HDTV (an LG model), so the Mac mini got an upgrade of sorts as well. I could now connect it to the TV with a DVI-to-HDMI cable. The Mac mini was able to output a crystal-clear 1360×768 resolution on the TV, making navigating around the TV a bit easier. Still, it meant that I needed a wired keyboard and mouse to control things, meaning a couple of USB extension cables and an old Apple Pro Keyboard I had lying around.
The Mac mini was pretty good for YouTube, watching and recording TV shows, and streaming music/media from my MacBook, but I wanted to use it for more things. Unfortunately, Hulu had issues, due to the G4 processor and Adobe Flash not agreeing the best (I blame Flash), but was still watchable. One really cool use I found was to use my MLB Gameday Audio subscription mixed with Yahoo GameChannel to create a pretty usable way to follow Cubs games not televised in my area.
Finally, I picked up (reviews to follow eventually?) an Apple Bluetooth Keyboard and a Rocketfish Bluetooth Laser Mouse — it was on sale for $25 — to allow control of my Mac mini from anywhere in my living room. The keyboard is excellent for this use, due to its small size (although I would've loved a MacBook-like MultiTouch trackpad in the mix). Programming Front Row to be activated via F5 allowed me to use the keyboard almost like an oversized remote.
Right now, there isn't much else that I've found uses for the Mac mini, but I'm open to suggestions.


some comparison shots. How great is the Isofrane as a piece of design!
Just as handsome in 1973 as it is today.
Last edited by 3cGT on Mon Jun 01, 2015 2:49 am, edited 2 times in total.
Great pics. These CD-2s are photogenic.
Great pair and I agree isofrane is top of the food chain in the rubber strap category.
I think I'll put all my watches on Isofranes next week. I love those things.
Well I guess that since that was once one of Mike's there's always a chance it resurfaces.


The main goal of the LIFE project ConRaSi is to improve the conservation status of three threatened raptor species occurring in Sicily (Italy): Bonelli's eagle, Egyptian vulture and Lanner Falcon.
Halting or reducing significantly the illegal collection of eggs and nestlings.
Enhancing the trophic capacity with the aim to rise the bird reproductive rates.
Getting an exhaustive picture of distribution and demography of the targeted species.
Improving the knowledge of the Bonelli's eagle on the base of genetic analysis.
Adopting any necessary management tool so as to ensure the long term conservation of the targeted species.
Improving awareness and information of a broad local audience.
The project objectives will be achieved by implementing the following eight actions.
These are specific sound measures to achieve the conservation of the three targeted species.
Putting in place camera-traps and web-cameras to ensure a continuous monitoring of the nesting sites.
Ensuring a thorough monitoring in space and time of the targeted species.
Creating artificial warrens to improve the availability of the Bonelli's eagle main prey species; setting up a network of feeding points in the Egyptian vulture areas.
Bird ringing and tracking through GPS transmitters.
Genetic sampling of feathers and other materials collected at the Bonelli's eagle nesting sites.
Development of habitat suitability models for each of the targeted species.
Delivering an action plan for the Bonelli's eagle.
Carrying out several communication activities, targeting specific audiences.
The LIFE ConRaSi targets nine Special Protection Areas (SPA), i.e. priority areas identified in accordance with the EU Birds Directive.
In this page section you can find the list of the main expected results of the LIFE ConRaSi Project.
At the end of the project the following results are expected to be achieved.
Up to 80-90% reduction in the illegal collection of Bonelli's eagle eggs and nestlings and significant reduction of this threat for the Lanner Falcon.
Significant enhancement of the Egyptian vulture population.
Exhaustive census of Bonelli's eagle and Egyptian vulture populations throughout Sicily and of Lanner Falcon within the targeted SPAs.
Improvement of the scientific knowledge of the targeted species.
The project ConRaSi is supported by the LIFE Programme of the European Union.


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Nowadays, a number of modern techniques are used to clean and maintain new granite memorials that may not be applicable for old stones. Each columbarium and monument stone needs its own diagnosis. Always contact a professional if you would like a more detailed understanding of cleaning granite memorial stones. It is important to understand the stone's distinct qualities and properties. Bronze memorial plaques used to embellish a columbarium design or monument design also require special attention.
SCIPL is a leading sales training company Nagpur, India offers corporate sales training for direct sales, channel sales, cold calls, lead generation, sales negotiation skills, ACY sales management, key account management. Help to manage, grow and optimize sales operations and distribution channels.
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Deyari was conceived to construct the projects arising out of the Trust's development activities. It conducts its operations through a development lens ensuring that construction activity and physical infrastructures serve the needs of local communities, as much as, they meet the technical requirements of the project at hand. Deyari purposely sources labour and raw materials from the localities of the projects at hand; it offers training to those willing to apply themselves to a new trade and relies on local workers to maintain physical spaces once the construction is complete. As a result, Deyari is able to turn the construction of development infrastructure into a development opportunity for local communities. Since inception, Deyari's unique approach has attracted interest from the private sector, which has resulted in unanticipated income generating opportunities for the Trust.


We are a husband and wife team, so due to a family emergency we've had to close reservations for Knockerball & Archery Tag until April 29th. We are working on a temporary staffing solution to open a few days during school vacation. If you would like to be on our call back list for these date openings, please call 603-662-0326 and leave your name, number and group size. We are sorry for any inconvenience this may cause and are working hard to create a solution to accommodate our customers. Thank you for understanding.
Our indoor facility, located in Conway Marketplace, features a 30 yard, 5,000 sq. ft. artificial turf playing field: the only one in the North Conway area! There are endless possibilities with this space, so we're always looking for new and creative ways to use it and provide our customers with a variety of activities. We offer KnockerBall, which is a plastic "bubble" you wear to play various full contact games in, including soccer. We also have Archery Tag which is a fun mixture of paintball, archery, and tag. You hide behind inflatable bunkers and try to stay in the game! Multiple games to choose from including secret service, revolutionary war, capture the flag and more! We also use our field to host toddler play groups and after school groups, fitness classes and seasonal private practices for soccer and field hockey, as well as various leagues including flag football and Archery Tag. For pricing information regarding any of our weekly events, please go to the event page found under the "Other Sports & Fitness" tab.
Each person has their own "bubble" that you wear like a backpack as we play all kinds of games, including our most popular "Knocker Soccer" (full contact soccer), musical chairs, sharks and minnows, and more!
Exciting mix of paintball, backyard tag, and archery! Chase your friends around, ducking behind barriers trying to stay alive! We utilize the full length of our playing surface (30 yards) and inflatable "bunkers" to create a course of obstacles and mayhem for our Archers! All Gear included and fun for almost all ages.
The best party/event you'll ever have! We take care of it all and have some great packages for small-large parties. Utilize our facility and you get your own private field, dedicated KB staff member, access to our party room, and full control over what games you play!
We're the only turf facility in the Mount Washington Valley, and we're taking full advantage! We're big on sports & fitness and bringing them to our facility!
To ensure our customers are safe and having fun while playing Knockerball and Archery Tag, we obtained official certification from Knockerball USA verifying insurance, background checks and completed safety training.


text:
Eduard (Edu) Waskowsky (Rotterdam, 1 december 1934 – Groningen, 31 december 1976) was een Nederlands schilder en beeldhouwer.

Leven en werk

Jeugd en opleiding
Waskowsky was een zoon van Eduard Waskoswky, stoker op de binnenvaart (ook genoemd als pijpfitter bij Werkspoor), en Petronella Alberta Kerkhof. Hij was een jongere broer van de dichter Riekus Waskowsky. Waskowsky ging na de lagere school naar de ambachtsschool, waar hij onder andere leerde lassen. Vervolgens volgde hij twee jaar een studie scheepsbouwkunde aan de hogere technische school van Dordrecht, die hij niet afmaakte. Van 1952 tot 1955 volgde hij schilderlessen aan de kunstacademie in Rotterdam. Af en toe werkte hij als lasser op Rotterdamse scheepswerven. Ook de kunstacademie leverde geen diploma op: in het laatste jaar wenste Waskowsky - tegen de wil van zijn ouders en school in - geen eindexamen te doen en hij verliet de academie voortijdig.

Latere leven
In 1957 verhuisde Waskowsky naar het Groningse Wedde, omdat zijn toenmalige vrouw Mieke Fischer daar een baan kreeg aangeboden. Hier raakte hij bevriend met de kunstenaars Jo van Dijk en Martin Tissing. Een jaar later maakte hij zijn eerste ruimtelijke beelden in ijzer en hout. In 1962 verhuisde Waskowsky naar de stad Groningen en in 1963 scheidde hij van Fischer. Hij trouwde met Japien met wie hij twee zonen zou krijgen.

Samen met Tissing, Van Dijk en Henri de Wolf vormde Waskowsky het kunstenaarscollectief Gr4K. Zij exposeerden in 1965 in het Groninger Museum. Waskowsky nam onder andere deel aan de Achtste Biënnale Middelheim in Antwerpen en in 1966 aan een tentoonstelling in het Musée Rodin in Parijs.

Hoewel Waskowsky begin jaren 1960 relatief veel bekendheid genoot, werd zijn werk in die periode weinig verkocht. Voor financiële ondersteuning deed hij in 1963 een beroep op de Beeldende Kunstenaars Regeling. Eind jaren zestig mocht Waskowsky enkele monumenten vervaardigen; onder meer een beeld voor het nieuwe politiebureau in Ter Apel (1966) en een messing plastiek voor de Groningse Van Lieflandschool (1969).

Joods monument

In 1969 kreeg Waskowsky van het comité Joods Monument de opdracht een monument ter nagedachtenis van de ruim 3000 in de Tweede Wereldoorlog omgekomen Joodse Groningers te maken. Het kreeg een plaats aan de Hereweg en is in 1977, na zijn overlijden, in onvoltooide staat onthuld. Het was namelijk uitdrukkelijk Waskowsky's wens dat het niet door iemand anders werd afgemaakt.

Afbeeldingen

Nederlands beeldhouwer

redpajama_set_name: RedPajamaWikipedia


text:
Overview of ZIP Code 62642, Illinois (ZIP Code)
Elementary School Districts
Secondary School Districts
Precincts:
Greenview No. 6, Indian Creek No. 7, Irish Grove No. 4, Sugar Grove No. 5
Villages:
Unified School Districts:
Greenview 200, Porta 202
New Holland-Middletown 88
Secondary School District:
Neighboring ZIP Codes:
Nearby ZIP Codes:
62625, 62633, 62634, 62655, 62671, 62673, 62682, 62684, 62688, 62693
ZIP Code 62642, Illinois (ZIP Code)
Updated on Sep 12, 2018, v1.1.47f4e218c70bb1d372358a740fe7c6466dbac1ac


Check drawn on the Office of Readen and Mallory to Thomas Simms and Levy(?) for $773.30 - Front. November 11, 1876. Special Collections, University of Houston Libraries. University of Houston Digital Library. Web. April 20, 2019. https://digital.lib.uh.edu/collection/earlytex/item/4056/show/4054.
Check drawn on the Office of Readen and Mallory to Thomas Simms and Levy(?) for $773.30 - Front, November 11, 1876, Early Texas Documents, Special Collections, University of Houston Libraries, accessed April 20, 2019, https://digital.lib.uh.edu/collection/earlytex/item/4056/show/4054.
Description Check drawn on the Office of Readen and Mallory to Thomas Simms and Levy(?) for $773.30.


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Certified. Odometer is 17913 miles below market average! CARFAX One-Owner. Clean CARFAX.

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Black 2018 Ford Escape Titanium 4WD 6-Speed Automatic 20/27 City/Highway MPG

Ford Certified Pre-Owned Details:

 * Limited Warranty: 12 Month/12,000 Mile (whichever comes first) after new car warranty expires or from certified purchase date
 * Includes Rental Car and Trip Interruption Reimbursement
 * Powertrain Limited Warranty: 84 Month/100,000 Mile (whichever comes first) from original in-service date
 * 172 Point Inspection
 * Roadside Assistance
 * Transferable Warranty
 * Vehicle History
 * Warranty Deductible: $100

For More Details About This Vehicle Please CALL ! Paul Smith or Mike Habas at (910) 442-2690.
Priced below KBB Fair Purchase Price! CARFAX One-Owner. Clean CARFAX.

Shadow Black 2017 Ford Escape Titanium FWD 6-Speed Automatic 23/30 City/Highway MPG

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Magnetic 2016 Ford Escape SE 4WD 6-Speed Automatic 22/29 City/Highway MPG

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Recent Arrival! Odometer is 4685 miles below market average! Clean CARFAX.

White 2016 Ford Escape SE FWD 6-Speed Automatic 23/32 City/Highway MPG

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