With the exception of a few microbial organisms, iron is required for life on earth. Iron serves as an important cofactor for a variety of enzymes that perform crucial reactions, including roles in cellular respiration, nucleic acid synthesis, and resistance to reactive oxygen intermediates. Fe(III) is very insoluble and frequently biologically inaccessible such that the concentration of available iron in the human host is ~10-9 mM. Since a typical pathogenic bacterium requires ~1 mM iron for optimal growth, these organisms have developed elaborate systems to scavenge iron from the host. The pathogens that we study use low molecular weight iron chelators called siderophores. The bacteria synthesize, secrete, and then selectively take up the iron-loaded siderophore to colonize human tissues. Non-ribosomal peptide synthetases (NRPSs) and their accessory proteins are a fascinating collection of enzymes required for the production of these bioactive peptides. Siderophore biosynthetic enzymes are found in plants, fungi and bacteria, frequently having no human homologues, making them attractive targets for the development of new antimicrobial compounds. The goal of the lab is to understand the structure-function relationships that drive the biosynthesis of siderophores, compounds linked to virulence and pathogenesis in a variety of deadly bacteria. The ultimate outcome of the work will be the structural biology and mechanistic enzymology required for the development of new antibiotics to fight many bacterial infections, including P. aeruginosa, an opportunistic pathogen that is problematic for cystic fibrosis and other susceptible patients, as well as for bacteria that generate chemically-related siderophores such as Yersinia pestis (plague), Vibrio cholera (cholera) and Mycobacterium tuberculosis (tuberculosis). The enzymes we study are also of interest to the protein engineering community, as many bioactive peptides contain similar chemical moieties and homologous enzymes are found in biosynthetic pathways of a variety of natural products. Two examples are epothilone and cyclosporin. Therefore, our work may also impact the design of new anti-cancer and immunosuppressive therapeutics.
Kenjic N, Hoag MR, Moraski GC, Caperelli CA, Moran GR, Lamb AL (2019). PvdF of pyoverdin biosynthesis is structurally unique N10-formyltetrahydrofolate-dependent formyltransferase. Archives of Biochemistry and Biophysics 664, 40-50.
McFarlane JS,Hagen R, Chilton AS, Forbes D, Lamb AL, Ellis HR (2019). Not as easy as pi: an insertional residue does not explain the pi-helix gain-of-function in two component FMN reductases. Protein Science 28, 123-134.
Ronnebaum TA, McFarlane JS, Prisinzano TE, Booker SJ, Lamb AL (2019). Stuffed methyltransferase domain catalyzes the penultimate step of pyochelin biosynthesis. Biochemistry 58, 665-678.
McFarlane JS, Davis CL, Lamb AL (2018). Staphyolopine, pseudopaline and yersinopine dehydrogenases: a structural and kinetic analysis of a new functional class of opine dehydrogenase. Journal of Biological Chemistry 293, 8009-8019.
Shelton CL, Lamb AL (2018). Unraveling the structure and mechanism of the MST(ery) enzymes. Trends in Biochemical Sciences 43, 342-357.
Ronnebaum TA, Lamb AL. (2018) Nonribosomal peptides for iron acquisition: pyochelin biosynthesis as a case study. Current Opinion in Structural Biology 53, 1-11.
McFarlane JS, Lamb AL. (2017) Biosynthesis of an Opine Metallophore by Pseudomonas aeruginosa. Biochemistry 56, 5967-5971.
Meneely KM, Ronnebaum TA, Riley AP, Prisinzano TE, Lamb AL. (2016) Holo structure and steady state kinetics of the thiazolinyl imine reductases for siderophore biosynthesis. Biochemistry 55, 5423-33.
Meneely KM, Sundlov JA, Gulick AM, Moran GR, Lamb AL. (2016) An open and shut case: the interaction of magnesium with MST enzymes. Journal of the American Chemical Society 138, 9277-93.
Lamb AL. (2015) Breaking a pathogen's iron will: inhibiting siderophore production as an antimicrobial strategy. Biochimica Biophysica Acta: Proteins and Proteomics 1854, 1054-1070.
Lamb AL, Kappock TJ, Silvaggi NR (2015) You are lost without a map: navigating the sea of protein structures. Biochimica Biophysica Acta: Proteins and Proteomics 1854, 258-268.
Meneely KM, Luo Q, Riley AP, Taylor B, Roy A, Stein RL, Prisinzano TE, Lamb AL. (2014) Expanding the results of a high throughput screen against an isochorismate-pyruvate lyase to enzymes of a similar scaffold or mechanism. Bioorg Med Chem. 22, 5961-69.
Chilton AS, Ellis AL, Lamb AL. (2014) Structure of an Aspergillus fumigatus old yellow enzymes (EasA) involved in ergot alkaloid biosynthesis. Acta Crystallogr F Struct Biol Commun. 70, 1328-32.
Meneely KM, Luo Q, Lamb AL. (2013) Redesign of MST enzymes to target lyase activity instead promotes mutase and dehydratase activities. Archives of Biochemistry and Biophysics. 539, 70-80.
Meneely KM, Luo Q, Dhar P, Lamb AL. (2013) Lysine221 is the general base residue of the isochorismate synthase from Pseudomonas aeruginosa (PchA) in a reaction that is diffusion limited. Archives of Biochemistry and Biophysics. 538, 49-56.
Meneely KM, Lamb AL. (2012) Two structures of a thiazolinyl imine reductase from Yersinia enterocolitica provide insight into catalysis and binding to the nonribosomal peptide synthetase module of HMWP1. Biochemistry. 52, 9002-13.
Olucha J, Meneely KM, Lamb AL. (2012) Modification of residue 42 of the active site loop with a lysine-mimetic sidechain rescues isochorismate-pyruvate lyase activity in Pseudomonas aeruginosa PchB. Biochemistry. 51, 7525-38.
Lamb AL. (2011) Pericyclic reactions catalyzed by chorismate-utilizing enzymes. Biochemistry. 50, 7476-7483.
Olucha J, Lamb AL. (2011) Mechanistic and structural studies of the N-hydroxylating flavoprotein monooxygenases. Bioorganic Chemistry. 39, 171-177.
Olucha J, Ouellette AN, Luo Q, Lamb AL. (2011). pH dependence of catalysis by Pseudomonas aeruginosa isochorismate-pyruvate lyase: implications for transition state stabilization and the role of lysine 42. Biochemistry. 50, 7198-207.
Luo Q, Meneely KM, Lamb, AL. (2011). Entropic and enthalpic components of catalysis in the mutase and lyase activities of Pseudomonas aeruginosa PchB. J. Am. Chem. Soc. 133, 7229-7233.
Luo Q, Olucha J, Lamb AL. (2009). Stucture-function analyses of isochorismate-pyruvate lyase from Pseudomonas aeruginosa suggest differing catalytic mechanisms for the two pericyclic reactions of this bifunctional enzyme. Biochemistry 48,5239-5245.
Meneely KM, Barr E, Bollinger JM, Lamb AL. (2009). Kinetic mechanism of ornithine hydroxylase (PvdA) from Pseudomonas aeruginosa: substrate triggering of O2 addition but not flavin reduction. Biochemistry 48, 4371-4376.
Search PubMed for articles by Audrey L. Lamb.


Four days packed with events for all ages.
Why does a growing group of partners produce the Wisconsin Science Festival?
The Wisconsin Science Festival aims to inspire and engage us in the enterprise of science and discovery; to cultivate curiosity and communicate the power of knowledge and creativity to change our world view; to promote innovation and to cultivate the next generation of global citizens. The Wisconsin Science Festival is presented by a growing coalition of Wisconsin's science and arts communities.
There are activities for all ages and interests, throughout Wisconsin, with many events held at the Discovery Building in Madison.
Some activities may have a nominal charge for materials or meals, and some partner locations charge their regular admission fees, however most events are free!


Without a strategy to guide all marketing activities, it's very likely that your efforts could flop. At SJC Marketing, our strategy sessions are intensive and interactive. We challenge our clients to think like their target market and dig down to goals and business challenges, strengths, weaknesses, opportunities and threats.
We talk through who your target audience is and just where they can be found. Together, we will develop strategic marketing plans with impactful and consistently creative content to tell your brand story. Your message will be heard loud and clear by the people who need to hear it, through the primary channels they use to make decisions.


8.30 am Hand bell – entry into playground, NOT into buildings unless it is raining or on a teacher's express permission.
8.50 am Bell – school starts – children hang up bags, coats, etc., and prepare for the day – teachers begin administration, roll, money, etc.
10.50 am Bell – classroom.
12.30 pm Bell – lunch break.
3.00 pm Bell – home time.


What is Love? How do you embrace love in today's business environment? Is a loving relationship realistic? Is it possible to avoid separation through love? How can you determine whether you're dating the right person? How can you give more love to yourself? Can businesses increase market shares while investing in human capital?
The answers to these challenging questions lie within this short video. This Powerful video shows you ways to attract more love in every aspect of your life. Check out this exciting video now!


I'm always looking for comfortable swimwear that I can actually do activities in, and Coral Reef Swim has tons of cute styles and options for this! I love that they have good coverage, but they're still cute! And they can all be mixed and matched! Their palm and gingham prints are so cute this year! Click continue reading to get some discounts on this outfit!
Alright, you guys are going to love me because I have discount codes for my swimsuit AND my hat!


Nao, a social robot developed by Aldebaran Robotics, a French company specializing in humanoid robots.
In the study, participants could help Nao, a human-like robot, calibrate its eyes, or Nao could examine the human's eye as if it was a concerned doctor and make suggestions to improve vision. After the task, the participants were asked how they felt about the robot.
"This is because the caregiving role assigned to the robot increases users' perceptual benefit of their relationship with the robot while enhancing their feelings of social presence," Ki Joon Kim, a graduate student in the department of interaction science at Sungkyunkwan University in Korea, explained in an email to NBC News.
The research calls to mind the Tamagotchi handheld pets that were insanely popular in the late 1990s. Owners fed and played with the toy in order to keep it alive. Too little care and it died. To avoid such disaster, some owners hired Tamagotchi-sitters to care for their toys in their absence.
The popularity of the virtual pets shows that humans are also capable of feeling compassion for digital devices that need care, but do so when the device is presented as a pet, Shyam Sundar, co-director of the Media Effects Research Laboratory at Pennsylvania State University, noted.
"When a robot is assigned the role of a pet, users will apply the same rules that we have for dealing with real animals as pets," he said in an email to NBC News. "We take care of their basic survival in exchange for companionship, emotional expression, soothing tactile interaction and unconditional loyalty."
The finding should help guide the design of home assistant robots, which could one day do everything from cook meals and clean the house to play a game of catch with Grandpa or Fido.
"When designers want a robot that users can trust, they should focus on their helper role," explained Sundar. "But, when they want to build robots for providing humanlike companionship, they should focus more on building social cues."
The research appears in the current issue of the journal Computers in Human Behavior.


'What fires together wires together' – the brain will strengthen anything you pay attention to with intensity – whether it's good, bad or indifferent for you.
The brain is very 'plastic' it can change – but you need to use your mind to take charge of what you want to think about rather than what the 'survival' brain wants you to think about.
Left to its own devices the brain will worry.
Persist in re-focusing your brain onto positive things, trains of thought, memories etc. Use your mind to train your brain into better habits.
The brain does not make your main 'feel good' neurotransmitter Serotonin – your digestive system does.
Keep your digestion healthy by eating unprocessed, whole and where possible organic foods.
The brain is largely composed of fat and water – don't starve it of either one of these, or of carbohydrates and protein to make serotonin.
Drink lots of water and eat foods rich in Omega 3 oil (fish) and Omega 6 (olives and olive oil), also B vitamins (whole grains). Also anti-oxidants (colourful, fresh fruits and vegetables and berries) and folate from beans and leafy greens.
The brain loves novelty, it gets bored easily. Doing the same kind of thing over and over may seem like brain exercise – like crosswords for example – but to the brain it's 'ho-hum' stuff. Always give the brain something new – a language other than your first language is great because you're always learning new stuff – dancing is great because it exercises the brain (you're always learning new stuff), as well as the heart (it's great exercise).
Remember the brain strengthens whatever we pay attention to, be careful what you're paying attention to.
A racing brain makes for stress and lack of sleep. Learn how to quiet your brain and nervous system. 'Wind down' before sleep and spend some quiet time each day. Meditation is great.
Mindfulness breathing is great (come and learn my method) because it focuses the brain onto nothing (at least nothing it can stress about).
Don't over-stimulate or anesthetize the brain before sleep (violent TV, caffeine or alcohol).
Do everything you can to get a good night's sleep. Meditate! Breathe!
5. Healthy heart – healthy brain!
Do whatever you can to make your heart as healthy as possible. Do physical exercise, eat healthy food with good oils, lower your stress. Do what you can to increase circulation and oxygen to the heart and brain. Dance, sing (singing and music in general is good for your brain and emotional health).
Exercise, lower stress, improve circulation Take a heart dose of asprin, eat for your heart and you'll eat for your brain.
If you don't want the brain to stress, keep it occupied by doing things, and being with people; that you love. Follow your passion, whatever it is. Make a list of all the people, activities, thoughts, places, memories and things that make you feel good. Love is the opposite of fear and fear = anxiety.
Follow your passion for people and life – do what you love.
Think about taking fish oil, ginko biloba for circulation, Vitamin B (especially B3 and B6), magnesium complex, co-enzyme Q10 and folate or get a great brain health formula from your naturopath or complementary health practitioner.
REMEMBER – YOU ARE WHAT YOU THINK!


text:
Bills vs Dolphins NFL live stream reddit: How to watch Week 3 – FanSided
MIAMI GARDENS, FLORIDA – AUGUST 27: Tua Tagovailoa #1 of the Miami Dolphins warms up before the preseason game against the Philadelphia Eagles at Hard Rock Stadium on August 27, 2022 in Miami Gardens, Florida. (Photo by Eric Espada/Getty Images)
The Miami Dolphins will host the Buffalo Bills, their biggest division rival, on Sunday for Week 3 of the 2022 NFL season.
The Miami Dolphins will host the Buffalo Bills, their biggest division rival, on Sunday for Week 3 of the 2022 NFL season. Each team is 2-0 this season and has had great success, so the game will certainly be a competitive matchup with a lot of action.
The Dolphins have been on fire with the great duo of Tua Tagovailoa and Tyreek Hill. They beat another division rival, the New England Patriots, in Week 1 with a final score of 20-7. They went on to beat the Baltimore Ravens in their first road game of the season during Week 2, a game they played down to the last second. The Ravens held a 35-14 lead, which the Dolphins came back from and won 42-38.
The Bills have also been playing extremely well with their star quarterback Josh Allen. They crushed the Tennessee Titans in Week 2 with a final score of 41-7. In Week 1, they beat out the defending Super Bowl champions, the Los Angeles Rams, with a score of 31-10.
Both teams are undoubtedly threats in the league this season, and this direct matchup will be a good predictor of who may win the AFC East.
The division matchup will be streamed on CBS from Hard Rock Stadium in Miami for all viewers with an active cable subscription. Viewers without one can stream the game through Paramount+. A subscription is required, but a one-month free trial is available for all new users.
There are, unfortunately, quite a few players inactive for the Bills this week. Players that will not be playing in Week 3 include:
The Dolphins have just two inactives and a mix of questionable and unlisted status players. Inactives for the Dolphins in Week 3 include tight ends Cethan Carter and Hunter Long.
As stated above, viewers can watch the game on CBS with an active cable subscription or can stream it through Paramount+ with a subscription.
There's the option to Google "sportsurge" or "NFL reddit live stream" to find free streams, but neither are official broadcasts by the NFL so it poses the risk of buffering or cutting out. Always exercise caution when using these methods.
Build your custom FanSided Daily email newsletter with news and analysis on All NFL and all your favorite sports teams, TV shows, and more.
© 2023 Minute Media – All Rights Reserved. The content on this site is for entertainment and educational purposes only. All advice, including picks and predictions, is based on individual commentators' opinions and not that of Minute Media or its related brands. All picks and predictions are suggestions only. No one should expect to make money from the picks and predictions discussed on this website. For more information, please read our Legal Disclaimer. If you or someone you know has a gambling problem, call 1-800-GAMBLER.
MLB Reportedly Wants A Stake in Bally Sports RSNs, Streaming Service – Cord Cutters News
Bills vs. Bengals odds, picks, line, how to watch, live stream, start time: Top 2023 NFL playoff predictions – CBS Sports

redpajama_set_name: RedPajamaCommonCrawl


Kumoro, A.C. and Hasan, M. (2006) Extraction of Diterpenoid Lactones of Andrographis paniculata using Liquid Solvents: Effect of Solvent's Hildebrand Solubility Parameter on Extraction Efficiency. In: 4th National Technical Postgraduate Symposium, Petaling Jaya, MALAYSIA.
Two diterpenoid lactones responsible to the multi healing properties of Andrographis paniculata have been extracted using 16 different liquid solvents. The effect of Hildebrand solubility parameter of the solvents on solid-liquid extraction yield using standard soxhlet extraction method was investigated. The Hildebrand solubility parameter concept performed well when predicting lower polar solvent effect on extraction efficiency. However, ethanol extracted less andrographolide than methanol even though ethanol has closer Hildebrand solubility parameter value to andrographolide compared to that of methanol. Methanol's shorter aliphatic chain and higher polarity, which lead to easier hydroxyl group liberation, seemed to contribute this discrepancy.
extraction, diterpenoid lactones, Andrographis paniculata, solvent, Hildeband solubility parameter.


Hot off the press is the addition of Jerry Howarth and Dr. Amanda Visek, the two latest all-star speakers to join the 2019 Ontario Coaches Conferences April 5-7, in Markham. They join a full contingent of 20 of North America's and the world's best scientists, coaches and practitioners leading 40+ hours of practical takeaways at Ontario's premier sport leadership event.
For 36 years, Jerry Howarth was the radio broadcaster for the Toronto Blue Jays. In 1982, Jerry joined Tom Cheek and for the next 23 years, "Tom and Jerry" were the voices of the franchise. Jerry called over 7,500 games in his professional career which included Toronto's back-to-back World Series Championships in 1992 and 1993.
Jerry also coached basketball for 25 years including the last twenty at the high school level moving from the Boys Bantam coach at Etobicoke Collegiate to their Junior coach and finally the Senior Boys coach playing for two Etobicoke City Championships along the way. Jerry brings special access to both his coaching style and to the Blue Jays clubhouse, discussing how the Blue Jays championships were won through excellent coaching under manager Cito Gaston as well as solid player development under the guidance of General Manager Pat Gillick.
Amanda J. Visek, PhD, CMPC is an Associate Professor in the Department of Exercise & Nutrition Sciences in the Milken Institute School of Public Health at The George Washington University in Washington, D.C., USA. Her scientific research has focused on the application of pediatric sport psychology to issues of public health, namely improving child and adolescent health outcomes by establishing sport participation as a public health practice through safe, positive physical activity and human movement experiences that are fun. Her federally funded, applied research includes the FUN MAPS, the latest sport science advancement capturing attention from local grassroots communities to national and international sport organizations.
The FUN MAPS are the scientific blueprints for the fun integration theory, the first-ever fully conceptual framework for optimizing youth's positive sport experiences, both in their childhood and through their adolescence. Her work has been featured nationally in USA Today, the Washington Post, the Huffington Post, ESPNW, the N.Y Times for Kids, U.S. News & World Report, National Public Radio, CBS Radio, ABC News, NBC News, NBC Sports, FOX News and many others, while also being featured globally. She has authored over 28 peer-reviewed papers, 7 book chapters, and given more than 142 refereed and invited talks around the world.
For more information and a full list of speakers and sessions visit www.coachesontario.ca/conference. If you are a local Markham/York Region resident ask how you can save even more!
Described as the "best conference I have ever attended," coaches are able to participate in this professional development opportunity at a subsidized rate. As the place to be for all things sport for twelve years running, the 2019 conference is themed around 'Winning Every Play' and guiding sport leaders to learn and understand how you can win every moment, interaction and play to ensure positive long term athlete success.
Home » Stars Just Added to #OCC19!


Megan Chatelain scored the game-winning goal via a Megan Hampe assist with 2:30 remaining as the Leopards won on the road verse the Wildcats 2-1. Morgan Keelan also scored a second half goal for 3-11 Louisville.
Riley Adams, Hunter Foley, and Austin Smith each scored goals as Louisville won at Canton South 3-2 in scrimmage action Tuesday. The Leopards finish the preseason with a mark of 3-1.
Max Hartline Ran for 3 touchdowns and also scored on a punt return to lead the Leopards past the Wildcats 36-20 in the season finale. Colton Jones and Davis Burick also hooked up for a touchdown pass as Louisville finished 5-5.
Bailey Adams scored 4 goals to lead Louisville to a 7-2 road win at Canton South in the regular season finale. Hunter Foley also scored a pair of goals and Logan Rich added another for the 7-7-2 Leopards.
The Leopards clinched their third NBC Title with a 12-0 win against the Wildcats. Louisville is now unbeaten in their past 10 games, which is a new team record.
Rahzul Young rushed for three touchdowns & Brock Haren scored a pair of touchdowns to lead the Leopards past the Wildcats 44-21 in clinching their third straight Outright NBC Title.
Trevor Burk scored a pair of goals and Bailey Adams added another as the Leopards earned a road win over the Wildcats 3-1. Alex Stefanik also had 2 assists for Louisville.
The Boys took second place at the NBC Meet, while the Girls took first place to claim their 7th NBC Title in 8 seasons. See full results in this post.


If you want to achieve your dreams you must put aside all the worldly passions of money, material possessions, and what people think of you. In order to reach your purpose in life you must dare to be different from others. If you are going to reach the dream God has given you, you must dare to be different.
It doesn't matter who you are or what you do or even where you've been, deep down their is void. And only Jesus Christ can fill the emptiness and longing of man's soul. We all need the presence of the Lord's Spirit. We long for it. We may try to get by on our own and we may even think we have it all together but if we search our hearts long enough we'll find an emptiness that cannot be met by material things or by our relationships.
Dare to be different. Dare to take a chance on Jesus. Dare to put your trust in His hands and then watch the Holy Spirit work in your life.
Do you want to live your passions? Do you want to make a difference in this life? Then do what Noah did, step out in faith. Take a risk in what God is asking you to do. Follow The One architect who knows how it's all put together. Be brave. Have faith. Enjoy life. Find your niche. You have just one life and there is a purpose for it.
Compelling! Thanks for sharing your thoughts. I hope you have many, many readers of this post.


text:
Graphics (13) Apply Graphics filter
Essays and Theses (11) Apply Essays and Theses filter
The Dalkon Shield
The Dalkon Shield was an intrauterine contraceptive device (IUD) that women used in the early 1970s and 1980s. Produced by the A.H. Robins Company in the US, the Dalkon Shield was a contraceptive device placed directly into a woman's uterus that was supposed to prevent the development of a fetus in the uterus. In the 1980s, researchers uncovered an array of severe birth defects and injuries caused by the Dalkon shield, including pelvic infection, infertility, and death of the user. Eventually the A.H.
The Ponseti Method to Treat Club Foot
Ignacio Vives Ponseti developed a noninvasive method for treating congenital club foot in the US during the late 1940s. Congenital club foot is a birth deformity in which one or both of an infant's feet are rotated inward beneath the ankle, making normal movement rigid and painful. Ponseti developed a treatment method, later called the Ponseti method, that consisted of a series of manipulations and castings of the club foot performed in the first few months of life.
Paul Eugen Bleuler (1857–1939)
Paul Eugen Bleuler studied autism and schizophrenia, among other psychiatric disorders, throughout continental Europe in the early twentieth century. Bleuler worked as a psychiatrist caring for patients with psychiatric disorders at a variety of facilities in Europe. In 1908, Bleuler coined the term schizophrenia to describe a group of diseases that cause changes in thought processes and behavior in humans as well as difficulties relating to the world.
"Testing the Kin Selection Theory: Who Controls the Investments?" from The Ants (1990), by Bert Hölldobler and Edward O. Wilson
In "Testing the Kin Selection Theory: Who Controls the Investments?" Bert Hölldobler and Edward Osborne Wilson discussed the predictive power of kin selection theory, a theory about the evolution of social behaviors. As part of Hölldobler's and Wilson's 1990 book titled The Ants, Hölldobler and Wilson compared predictions about the reproductive practices of ants to data about the reproductive practices of ants. They showed that the data generally supported the expected behaviors proposed by kin selection theory.
Arthur William Galston (1920–2008)
Arthur W. Galston studied plant hormones in the United States during the late-twentieth century. His dissertation on the flowering process of soybean plants led others to develop Agent Orange, the most widely employed herbicide during the Vietnam War, used to defoliate forests and eliminate enemy cover and food sources. Galston protested the spraying of those defoliants in Vietnam, as they could be harmful to humans, animals, and the environment.
Ignacio Vives Ponseti (1914-2009)
Johns Hopkins Fertility Center
Johns Hopkins Medical Center, located in Baltimore, Maryland, opened in 1889; its associated medical school opened four years later. Today the hospital, a leading research center, contains many departments, including a fertility center that is renowned for taking on difficult cases that have been rejected by other fertility clinics. The fertility center was founded by physician Georgeanna Seegar Jones in 1939 as the Division of Reproductive Endocrinology in the gynecology department. The division expanded once formal training in reproductive endocrinology began in 1973.
Thesis: The Human Genome Project and ELSI: The Imperative of Technology and Reduction of the Public Ethics Debate
Portrayed as the Manhattan Project of the late 20th century, the Human Genome Project, or HGP, not only undertook the science of sequencing the human genome but also the ethics of it. For this thesis I ask how the HGP did this; what was the range of possibilities of goods and evils imagined by the HGP; and what, if anything, was left out.
Subject: Ethics, Organizations
"Autistic Disturbances of Affective Contact" (1943), by Leo Kanner
Leo Kanner published Autistic Disturbances of Affective Contact in 1943 in the journal Nervous Child. This article described the cases of eleven children with autism. Kanner described the behavior and upbringing of each child, aged two to eight, as well as the educational backgrounds of the children's.
Paul Kammerer's Experiments on the Midwife Toad (1905-1910)
In the first decade of the twentieth century, Paul Kammerer, a zoologist working at the Vivarium in Vienna, Austria, conducted research on developmental mechanisms, including a series of breeding experiments on toads (Alytes obstetricans). Kammerer claimed that his results demonstrated that organisms could transmit acquired characteristics to their offspring.
Paul Kammerer (1880-1926)
Paul Kammerer conducted experiments on amphibians and marine animals at the Vivarium, a research institute in Vienna, Austria, in the early twentieth century. Kammerer bred organisms in captivity, and he induced them to develop particular adaptations, which Kammerer claimed the organismss offspring would inherit. Kammerer argued that his results demonstrated the inheritance of acquired characteristics, or Lamarckian inheritance. The Lamarckian theory of inheritance posits that individuals transmit acquired traits to their offspring.
Subject: Experiments, People
The Time Has Come: A Catholic Doctor's Proposals to End the Battle over Birth Control (1963), by John Rock
In 1963, Roman Catholic fertility doctor John Rock published The Time Has Come: A Catholic Doctor's Proposals to End the Battle over Birth Control, a first-person treatise on the use of scientifically approved forms of birth control for Catholic couples. The first contraceptive pill, called Enovid, had been on the market since June 1960, and Rock was one of the leading researchers in its development. In The Time Has Come, Rock explicitly describes the arguments for and against the use of birth control from both a religious and a scientific perspective.
Subject: Publications, Religion, Reproduction
Sex in a Cold Climate (1998)
In 1998, Testimony Films released the documentary Sex in a Cold Climate, which reported the true stories of four survivors from the Magdalene asylums in Ireland in the twentieth century. Magdalene asylums, also called Magdalene laundries and homes, were institutions of the Catholic Church that sought to reform women engaged in prostitution and those who birthed children out of wedlock by forcing the women to do hard labor.
Subject: Outreach, Publications
"The Premenstrual Syndrome" (1953), by Raymond Greene and Katharina Dalton
In 1953, Raymond Greene and Katharina Dalton, who were doctors in the UK, published The Premenstrual Syndrome in the British Medical Journal. In their article, Dalton and Greene established the term premenstrual syndrome (PMS). The authors defined PMS as a cluster of symptoms that include bloating, breast pain, migraine-headache, fatigue, anxiety, depression, and irritability. The article states that the symptoms begin one to two weeks before menstruation during the luteal phase of the menstrual cycle, and they disappear upon the onset of the menstrual period.
Subject: Publications, Reproduction
Mary Warnock (1924–2019 )
Baroness Mary Warnock of Weeke, a philosopher and crossbench member and Life Peer of the United Kingdom's House of Lords, participated in several national British committees of inquiry that dealt with ethical and policy issues surrounding animal experimentation, pollution, genetics, and euthanasia to educational policies for children with special needs. One of these was the Committee of Inquiry into Human Fertilization and Embryology, of which Warnock was the chair.
Boston Women's Health Book Collective, later Our Bodies Ourselves (1969–)
The Boston Women's Health Book Collective was a women's health organization headquartered in Boston, Massachusetts, that published the informational book Our Bodies Ourselves, which sold over 4.5 million copies. Initially called the Doctor's Group, the Collective formed in response to the insufficiency of women-specific health information during the late 1960s and early 1970s. Members of the organization participated in the women's liberation movement in Boston, Massachusetts, and conducted research on women's health using resources such as medical textbooks.
Medical Vibrators for Treatment of Female Hysteria
During the late 1800s through the early 1900s, physicians administered pelvic massages involving clitoral stimulation by early electronic vibrators as treatments for what was called female hysteria. Until the early 1900s, physicians used female hysteria as a diagnosis for women who reported a wide range of complaints and symptoms unexplainable by any other diagnosis at the time. According to historian Rachel Maines, physicians provided pelvic massages for thousands of years to female patients without it being considered erotic or sexually stimulating.
Subject: Reproduction, Technologies, Ethics
Ignaz Philipp Semmelweis (1818-1865)
Ignaz Philipp Semmelweis demonstrated that the use of disinfectants could reduce the occurrence of puerperal fever in patients in nineteenth century Austria. Puerperal fever is a bacterial infection that can occur in the uterine tract of women after giving birth or undergoing an abortion. Semmelweis determined that puerperal fever is contagious and argued that the unhygienic practices of physicians, like examining patients after performing autopsies, caused the spread of puerperal fever.
Niemann-Pick Disease
In 1914 Albert Niemann, a German pediatrician who primarily studied infant metabolism, published a description of an Ashkenazi Jewish infant with jaundice, nervous system and brain impairments, swollen lymph nodes (lymphadenopathy), and an enlarged liver and spleen (hepatosplenomegaly). He reported that these anatomical disturbances resulted in the premature death of the child at the age of eighteen months. After extensively studying the abnormal characteristics of the infant, Niemann came to the conclusion that the disease was a variant of Gaucher's disease.
"The Results of Operations for the Cure of Cancer of the Breast Performed at the Johns Hopkins Hospital from June, 1889, to January, 1894" (1894), by William Stewart Halsted
In 1894, William Stewart Halsted published The Results of Operations for the Cure of Cancer of the Breast Performed at the Johns Hopkins Hospital from June, 1889, to January, 1894, in the medical journal Annals of Surgery. In the article, Halsted describes the results from fifty of his operations on women with breast cancer, performed at Johns Hopkins Hospital in Baltimore, Maryland. Those operations involved a surgical procedure Halsted called radical mastectomy, which consists in removing all of the patient's breast tissue, chest muscle, and underarm lymph nodes.
The Boys from Brazil (1978)
The Boys from Brazil is a science fiction film based on the novel of the same name by Ira Levin about an underground neo-Nazi society in South America trying to clone Adolf Hitler, the dictator of Nazi Germany during World War II, to restore the Nazi movement. The film was directed by Franklin Schaffner and released in 1978 by 20th Century Fox in Los Angeles, California. The Boys from Brazil is a film that was one of the first films to depict cloning, and to discuss the ethical implications of genetic engineering, cloning, and eugenics.


We are seeking your views on whether the current approach to the new economic development strategy is right and to have a better understanding of your expectations.
To invest in our people ensuring they have right qualifications and access to skills provision.
Are these the right themes for the borough the focus on?
Are these the right activities?
You will be able to particpate in the development of the new strategy by answering the question on the online survey below.
Economic Growth Strategy survey March 2019 Start is neither a DataColumn nor a DataRelation for table . End is neither a DataColumn nor a DataRelation for table .


text:
Scouting in Kyrgyzstan was founded in November 1994 and is not yet a member of the World Organization of the Scout Movement, but is working toward WOSM recognition. Kyrgyzstan has multiple Scout associations, several of which are members of Kyrgyz Respublikasynyn Skaut Kengesh (Кыргыз Республикасынын Скаут Кеңеш), the Kyrgyz Republic Scouting Union.

Program and ideals

The goals of the Kyrgyz Republic Scouting Union federation are the creation of a Scout movement with a uniquely Kyrgyz character, guidelines for Scout membership and for training of leaders and application to the World Organization of the Scout Movement (WOSM). Among the multiple organizations, some are separated by gender—some for boys, others for girls—while others are coeducational. Various Scout factions in Bishkek agreed in 1995 that they wanted light blue uniforms, as light blue is the Kyrgyz color of courage and generosity (see also Mongolyn Skautyn Kholboo), and several world Scouting alumni organizations offered to make uniform insignia for the fledgling Kyrgyz Scouts, free of charge.

History

On October 29, 2004, six Scouts of Kyrgyzstan posted an official website for their organization after a weeklong Web design course at the Internet Access and Training Program (IATP) access site in Bishkek. The website contains pages about Scouting's mission, the history of Scouting in Kyrgyzstan and some of its activities, a copy of the organization's charter, a photo gallery, list of donors, a forum, and contact information. Организация Скауты Кыргызстана (ОСКыр) leader Evgeniî Shmelëv (originally leader of the Speleoklub "Надежда", the "Hope" Sporting Association, an early precursor to Scouting locally) remarked, "The Scouting movement in Kyrgyzstan is in its initial stage, and we hope to unite people who have common interests and enthusiasm under one identity called 'Scouts'. Moreover, we hope to get support from Scouting movements of foreign countries through the website." The Scouts have pledged to keep their website updated and maintain it as a dynamic, living online resource.

It is reported that total registered membership is 300.

The Scout Motto is "Dayar Bol", translating as "Be Prepared" in Kyrgyz, and "Bud' Gotov", translating likewise in Russian. The noun for a single Scout is Скаут in both languages.

Program sections
Cub Scouts-7 to 11
Scouts-12 to 15
Rovers-16 to 20

Kyrgyzstan Girl Scouts Association

The Kyrgyzstan Girl Scouts Association, Kyrgyzstan Skaut-Kyzdar Assotsiatsiyasy (KSKA), founded in September 1997, currently has 186 members. Aigul' Duîsheyevna Duîsheyeva is the chairwoman. KSKA, whose symbol is the snow leopard (Uncia uncia), has headquarters on köchösü Bokonbayev in Bishkek, courtesy of the Kyrgyzstan Women's Congress. Work towards World Association of Girl Guides and Girl Scouts membership recognition progressed in the late 1990s, but now remains unclear.

Multiple Kyrgyz Scout associations
Some of the multiple organizations sponsoring Scouting activities in Kyrgyzstan include
 Organization of Scouts of Kyrgyzstan (OSKyr) Организация Скауты Кыргызстана (ОСКыр), linked internationally to the Organization of Russian Young Pathfinders (ORYuR) Организации Российских Юных Разведчиков (ОРЮР)
 Kyrgyz Respublikasynyn Skauttarynyn Koomduk Birikmesi (KRSKB), the Public (Boy Scout) Scouts Union, currently functions in four of the seven dubans of Kyrgyzstan. The KRSKB plans to open a Scout café to earn money for their organization.
 Kyrgyz Skaut Uyumu, the Kyrgyz Scout Association
 Nezavisimyi Skautskîi Otryad shkoly No. 13 (Independent Scout Troop, School No. 13)
 the "Leader" Club for High School and University Students, Karakol
 Respublikanskîi Tsentr dlya Detei i Yunoshestva "Seitek"/Kyrgyz Respublikasynyn Baldar jana Ospurumdor Borboru "Seitek" (Seitek Independent School Association Republic Center for Children and Youth/Kyrgyz Republic Center for Children and Youth)
 Klub Zashchity Okruzhayushchei Sredy shkoly No. 28, Bishkek (the "Ilbirs" Children's Environmental Club, School No. 28, Bishkek)

International exchanges
Kyrgyzstan's Scouts have an international relationship with Pikes Peak Council in Colorado.

See also

World Organization of the Scout Movement
Organization of the Scout Movement of Kazakhstan
Ittihodi Scouthoi Tojikiston
Scouting in Turkmenistan
Scout Association of Uzbekistan
Scouting and Guiding in Mainland China

External links and references
official website

Kyrgyzstan
Organisations based in Kyrgyzstan
Youth organizations established in 1994

redpajama_set_name: RedPajamaWikipedia


Programa 3X1 para Migrantes (henceforth Programa 3X1) EUROsociAL Programme This report has been prepared by Alina Rocha Menocal , within the framework of an agreement signed between the Coordination Office of EUROsociAL - FIIAPP and Overseas Development Institute (ODI).
1ª parte. las organizaciones internacionales y la teoria de las relaciones internacionales 1. definicion y caracteres de las organizaciones internacionales.
TOPICS IN APPLIED ECONOMETRICS University of Houston Economics 6394 Professor Adriana Kugler Spring 2008 Tuesdays 10:00 a.m.-1:00 p.m. 212 McElhinney Hall This course exposes students to some of the most frequently used econometric techniques in applied microeconomic research.


text:
chuck wexler de-escalation deadly force guns let's be careful out there PERF plice state police culture Police Executive Research Forum police shooting police training policing pt Don't Make Officer Friendly Shoot You report research scotland second amendment shoot/dont'shoot study Tamir Rice use of force
Police Group Suggests Maybe Police Could Try Being A Little Less Shooty, Please
Doktor Zoom
Maybe we could give them axes instead
A national law enforcement organization released an important report calling for police departments to rethink their training and policies on use of deadly force, with less emphasis on "Shoot/Don't Shoot" decisions and more training on ways to de-escalate situations before a decision to use deadly force ever becomes necessary. The recommendations in the report, from the Police Executive Research Forum (PERF), are wise, humane, and actually give you some hope that America's police departments could be reformed into something the nation could be genuinely proud of. Needless to say, the report is doomed to be derided by the usual Git Tuff Law-N-Order mob as a bunch of criminal-coddling pabulum, since everyone knows the police are there to bust heads and terminate bad guys, even when they're 12 years old and not holding a real gun.
[contextly_sidebar id="FAXsNt0VyPfCyEidoPq51yZ9wMkwg61U"]
The report was distilled from a May 2015 conference involving "nearly 300 police chiefs and other law enforcement executives, federal government officials, [and] academics" from around the nation, as well as some visiting police officials from the UK, where most police manage crime without even carrying guns. Chuck Wexler, PERF's executive director, writes that while many of the highly publicized police shootings in the last year may have been ruled to be legally justified, that hardly means they were always necessary, since there are often "missed opportunities to ratchet down the encounter, to slow things down, to call in additional resources." Wexler's executive summary emphasizes the need to change police training and modify police culture, and highlights police departments that are taking steps to get their officers to unlearn their reflex of instantly going for the gun.
One of the biggest problems, he says, is training, especially in terms of how police officers are taught to interact with people who may be mentally ill but can be talked down instead of shot to death. Part of the problem is the fragmented nature of training in police academies, where cadets might first get firearms training, then several weeks later a brief discussion of legal/constitutional issues, and, almost as an afterthought, some mention of ways in which they might avoid using force in the first place.
Consider this somewhat depressing chart from the report, showing the number of hours dedicated to various aspects of police training:
Hey, there's nothing in there at all about creative means of planting evidence
Wexler calls for teaching cops that they have many tools to use before it's ever necessary to pull their sidearms:
We owe it to our officers to give them a wider range of options. "Shoot/don't shoot" training does not provide the full range of issues that officers need to consider. The question posed to officers in training should not be "shoot or don't shoot." Instead, officers should be trained to ask themselves a series of key questions as an event unfolds, such as "What exactly is happening? What is the nature of the risks or threats? What powers do I have legally and within policy to respond?Do I need to take action immediately? Am I the best person to deal with this? If I take a certain action, will my response be proportionate to the seriousness of the threat?"
Policing culture, Wexler says, needs to shift from an emphasis on not only protecting the life of the officer, but of valuing all life in the community. Yes, even the civilians! While the police mantra, "Your most important job is to get home safely to your family at the end of your shift," is worth preserving, it's also not the only consideration for an organization whose existence is supposed to be about protecting the whole community:
[A] number of police chiefs have called for a rethinking of the practice of emphasizing to officers on a daily basis that they face potential deadly threats at every moment. Why? Because some of the officer-involved shootings that have been most controversial seem to reflect training that has officers think solely about their own safety, rather than a broader approach designed to protect everyone's lives.
Of course, there are other cultural shifts that would help. For instance, encouraging cops who aren't having to deal with an active shooting situation to call for backup before jumping in with guns blazing, a practice that can save lives but is undercut if officers think they'll be seen as weak because they couldn't handle the situation themselves. Think Tamir Rice: Nobody reported shots fired, and the cops could easily have pulled up 20 feet away instead of right next to the kid, which would have allowed time to find out that he had an Airsoft pellet gun, not a real handgun.
Oh yes, and then there's the guns thing. Get ready for the NRA to decry PERF as a bunch of liberal Second Amendment haters, since Wexler acknowledges that while there's much that can be learned from police in other countries who are able to avoid resorting to deadly force, those foreign cops don't have to deal with the deadly reality of American policing:
[T]he United States faces much more severe problems than most other countries, stemming from the widespread availability of inexpensive, high-quality firearms to almost anyone. Regretfully, even people with long criminal records or histories of severe mental illness can easily obtain powerful firearms in the United States.
No, Wexler doesn't say he wants to take your precious guns. He's totally thinking it, though, the fascist. But even with all the guns out there, cops don't need to be so shooty. Want to have your mind blown? In Scotland, it's been three and a half years since police have used deadly force against a suspect, despite receiving 1.8 million emergency calls annually. In too many American departments, that might be seen as proof that cops lack ambition.
Or maybe it's a sign that American paranoia about the need for everyone to have a gun, to ward off a police state, has actually handed us a very deadly state of policing.
All in all, it's a hell of a good read and even includes plenty of examples of American police departments that are turning from a shoot/don't shoot culture toward an emphasis on slowing down and de-escalating situations whenever it's safe for officers to do so. No, Wexler isn't suggesting that cops try sweet reason with an armed lunatic has already opened fire on them. But the gun doesn't have to be the first choice, either.
We'd like to see police departments follow the advice of Sgt. Phil Esterhaus on Hill Street Blues, who ended every morning's briefing with "Let's be careful out there." After actor Michael Conrad died, "Sarge" was replaced with a different sergeant, whose catchphrase, "Let's do it to them before they do it to us," embodies just about everything that's gone wrong with American policing.
[HuffPo / Police Executive Research Forum]
Doktor Zoom's real name is Marty Kelley, and he lives in the wilds of Boise, Idaho. He is not a medical doctor, but does have a real PhD in Rhetoric. You should definitely donate some money to this little mommyblog where he has finally found acceptance and cat pictures. He is on maternity leave until 2033. Here is his Twitter, also. His quest to avoid prolixity is not going so great.


text:
Crews Race To Save Highway 50 In Sierra
Filed Under:Bay Area Storm, Highway 50, Sierra
PLACERVILLE (CBS SF & AP) – A portion of Highway 50 in the Sierra collapsed Tuesday, endangering the entire roadway and closing down a major traffic artery through the mountains, officials said.
Photos published by the CHP Placerville office showed a gaping hole where the shoulder of westbound Highway 50, east of Bridal Veil Falls in El Dorado County, lane No. 1 collapsed and the No. 2 lane buckling.
Authorities said the entire roadway located between Pollock Pines and Kyburz was in danger of collapsing
On the other major highway in the Sierra — I-80 — white-out snow conditions had triggered several accidents that forced the CHP to shut it down.
CalTrans Donner Pass Superintendent Dave Wood urged all travelers to avoid the area Tuesday. He said the conditions are "fierce."
An avalanche has also buried the main mountain highway between Reno and Lake Tahoe beneath some 20 feet of snow, but no injuries were reported.
Nevada Highway Patrol Trooper Dan Gordon said Tuesday there are no immediate reports that any motorists or vehicles were trapped in the snow slide near the crest of Mount Rose Highway.
He said the avalanche was reported about 9:15 p.m. Monday, and there's no estimate yet when the road will reopen.
California Highway Patrol in Truckee was reporting Tuesday evening that whiteout conditions had shut down I-80 in both directions.
Westbound I-80 was closed at the Nevada State Line, while eastbound was closed in Colfax. There was no projected time for the freeway to reopen.
More than 3 feet of snow has fallen in the last 24 hours and up to another 2 feet is possible into Wednesday. A winter storm warning remains in effect until 4:30 a.m. Wednesday.
A mix of rain and snow continues to fall in the valleys from Carson City to Reno. A record 1.05 inches of rain fell at Reno Tahoe Airport on Monday. The old record of 0.67 was set in 1992.
TM and © Copyright 2017 CBS Radio Inc. and its relevant subsidiaries. CBS RADIO and EYE Logo TM and Copyright 2017 CBS Broadcasting Inc. Used under license. All Rights Reserved. This material may not be published, broadcast, rewritten. The Associated Press contributed to this report.


Click here to view all details for Mattos Filho Veiga Filho Marrey Jr e Quiroga Advogados.
Mattos Filho, Veiga Filho, Marrey Jr e Quiroga Advogados is a market leader for legal services in Brazil. The firm has more than 30 practice areas covering a wide range of legal services. Our legal experts work together as one team to resolve the demands of their clients.
We are an organisation recognised for our innovative legal solutions to the most complex cases and our steadfast commitment to remain the firm of choice for our clients.
Such clients include large domestic and foreign corporations, major financial institutions, investors, multilateral agencies, investment funds, pension funds, insurers and reinsurers, public-sector and private companies in various industry sectors, non-profit organisations and government entities.
The firm is located in São Paulo and has additional offices in Rio de Janeiro, Brasília and New York.
To view all Mattos Filho Veiga Filho Marrey Jr e Quiroga Advogados lawyers by practice area, click here.


Home / Home & Kitchen / Mill Care / Wool Wax Creme 2 oz.
Wool Wax Creme 2 oz.
Looking for relief of dry skin? You have found an answer to your dry skin needs. Made of lanolin, this Wool Wax Creme has natural skin softening properties. Unlike other creams, the contents are non-hypoallergenic, and it's made in the USA. 2 oz. trial size. You have got to try this!
great stuff. Love the way it feels. I like the container too.
Wool Wax Creme is Fantastic!
I have problems with dry skin every winter. The worst places are my hands and feet. The skin dries and cracks beside my fingernails on my hands, and the soles of my feet get rough and dry. I've tried a lot of products to resolve these problems, but nothing worked...until I tried Wool Wax Creme. I can't believe what a huge difference the stuff makes! I apply a thin coat of wool wax creme once a day, or maybe every other day, and after a week or so, both my hands AND my feet actually became soft and smooth. Even those painful cracks on my fingers have closed. I don't get any compensation for this review--I have no connection with anybody at the Amanas, where I got this creme. I'm just happy to share a success story. Thank you, thank you, thank you!!!


Want to know how to delete songs from iPhone or iPad? As compared to iOS 7, you will have to take one more step to delete music in iOS 8 on your iPhone or iPad. For those of you who are battling with storage space on your iPhone, removing songs that you don't listen can be helpful.
There is more than one method of getting rid of all music. The easiest, however, is where you delete all music with just one kill switch. We've outlined that method here. Note that deleting all music on iOS 7 and iOS 8 is almost the same (except for one extra step in iOS 8).
Note: Before proceeding ahead, ensure that all music is in your iCloud (or backed up on your computer) so that you can get them bac.
You are done! All the music has been deleted from your music app.
What if you want all the music back again in your device? Remember that all music that is on your iCloud (that is, music you purchased through iTunes and music that you've uploaded through iTunes Match) will still be available. You just have to flip a switch to get them on your iPhone.
You should notice that while there is music back in your Music app, these are all shown with a tiny iCloud icon next to them. Tap on them and they will be downloaded to your iPhone/iPad. (You can also choose to just stream them, but that will use up your bandwidth).
Show All Music allows you to get back all the other downloaded music that was stored in your device or iCloud earlier.


text:
CHILD CARE COSTS IN BURT CLIMB UNDER THE LIBERALS NEW SUBSIDY
MATT KEOGH MP, FEDERAL MEMBER FOR BURT
Cash strapped parents are forking out up to 13% more than they were this time last year for child care.
The cost of child care in Burt has climbed since the introduction of the Federal Government's changes to the child care subsidy last year, with families continuing to be worse off under the scheme.
The Federal Government claimed they were easing the burden of child care on young families but instead, according to the government's own figures, 1 in 4 families would be left worse off by losing the subsidy.
Despite the Government's claim their child care subsidy changes would make it easier for working parents to afford care and get back to work, in many instances it's just seen increases to fees with no benefit to parents whatsoever.
Fees in one centre in Armadale have gone up $115 a week since April 2018 while one centre in Canning Vale has increased their daily rate by $36.
The new eligibility requirements for the subsidy have also created headaches for parents in Gosnells, with those running home businesses told they don't meet the requirements for assistance.
At the other end of the spectrum, parents in Armadale who take advantage of "long day care" while working full time are finding they're maxing out their subsidies and are penalised as a result.
It will cost, on average, $5,300 a year for families on less than $65,710 that don't meet the Liberals' new activity test to replace the day of early education they have lost working full time.
For single income families of those marginally attached to the labour market, they will pay more than $10,000 more a year to replace the two days of care they have lost.
In stark contrast, Labor has announced the biggest ever investment in early childhood education in Australia with our $1.75 billion National Preschool and Kindy Program.
Labor's plan will see around 700,000 three and four year olds access preschool and kindy every year. This will also help parents balance work and family and help reduce the child care bill for families with children already in early education.


text:
The Top 10 Shows on TV That Are Just Like "Single's Inferno"
By Peter Jordan Last updated Jan 4, 2023
The second season of Single's Inferno has ignited the internet as fans encourage their favourite cast members to marry their crush. On January 10, season 2 will regretfully come to an end, and we are eager to know who will finish up with whom.
We've got you covered if you're wondering what to watch next! As we cross our fingers and wait for season three, here are 10 comparable series you should add to your watch list!
Eden, Descendants of Instinct
Watch Eden if you thought Single's Inferno was seductive! The programme follows a group of attractive singles as they share a home and interact with one another. They are able to compete in games and win dates. They can't disclose their age or jobs until much later in the show.
Transit Love /EXchange
Contestants on this reality dating TV programme had a past relationship. They once dated before ending their relationship. The candidates live together in the same house for the duration of the show and have the opportunity to either create new relationships or get their ex back. The caveat is that they are not permitted to reveal their ex's identity to anyone.
Bed on The Beach
Young singles reside in a lavish vacation home on a picture-perfect island on this show. Without regular daily distractions, their sole objective is to engage with each other and discover love.
His Man
The first homosexual reality dating programme in Korea was this one. In the same home are eight beautiful gay single men. They converse with one another and ultimately hope to meet the one in the programme. The first season was a huge success, and fans can't wait for season 2.
Pink Lie
This programme attempts to determine whether love is actually unconditional. Young adults who are single move into the same home and are permitted one lie. They don't want the other members to learn about this, though. It could be anything, such as work, age, or familial ties. Feelings develop as they get to know one another and begin dating, but what happens when the truth comes out?
Love Catcher
Which would you pick, love or money? Ten participants live together for eight days on this show. Some of them—the so-called "love catchers"—seek romantic relationships, while others hope to earn 50 million won. The money catchers must locate and team up with a love catcher in order to win. Love catchers, on the other hand, should stay away from money catchers and look for a love-only spouse.
Read More: Trolley Episode 6: Date, Time, and Where to Watch a Sneak Peek!
Change Days
This program's interpretation of a reality dating show is intriguing. The programme brings together couples that are about to split up. They hang out together in the same house frequently. As they consider whether to end or save their relationship, they are free to interchange and date other people.
Love Mafia
This should be added to your watchlist if you enjoy a good chaotic reality dating show. Young single people enrol in the love school in this television show. There is a twist, though; two of them are actual couples. The genuine couples, commonly referred to as the mafia, must make sure they prevent the single couples from uniting and gaining $10,000. The mafia couple will keep the $10,000 if they are successful.
Read More: Alchemy of Souls Season 2 Episode 8: Date, Time, and Where to Watch a Sneak Peek!
I am Solo
The participants in this competition are looking for a spouse. To the Solo world, the six men and women are invited. They display their charm while at the Solo World in the hopes of meeting their soul mate and a partner for the rest of their lives.
Divorced Singles
This programme is evidence that falling in love can still happen after a divorce, and we all deserve to have as many opportunities as possible to find it. In the "divorced singles village," eight divorced men and women are followed by the show. They wish to experience heart-fluttering feelings and a second chance at love.
So there you have it—our list of 10 TV shows to watch in place of Single's Inferno on Netflix.
How do you feel about our choices? Do you concur? Exist any noteworthy omissions? Tell us in the comments section below!
Season 34, Episode 12: "My Life as a Vlog" of The Simpsons: A Recap and Review!
Season 2, Episodes 9–10 (Finale) of Single's Inferno: Release Date, Time, and Where to Watch Sneak Peek!


CloudBees, a San Francisco, CA-based enterprise DevOps company, acquired Electric Cloud, a market leader in continuous delivery and application release automation (ARA).
Coupa Software (NASDAQ: COUP), a San Mateo, CA-based business spend management (BSM) company, is to acquire Exari, a provider of contract lifecycle management (CLM).
Pine Labs, a New Delhi, India-based merchant platform company, is to acquire Qwikcilver, a Bangalore, India-based gift card solutions provider, for US$110m, subject to closing conditions.
Xoriant Corporation, a Sunnivale, California-based product engineering, software development, and technology services company, acquired CloudIO, an enterprise grade solution provider in the areas of IoT, supplier collaboration, and financial statement analysis.
Imbed Biosciences Inc., a Madison, Wis.-based medical device company emerging as a leader in the development of advanced therapies for soft tissue repair, closed $2m Series A equity financing.
Expedia Group, Inc. (NASDAQ: EXPE) is to acquire Liberty Expedia Holdings, Inc. (NASDAQ: LEXEA, LEXEB) in an all-stock transaction.
Sezzle, a Minneapolis, MN-based buy now pay later solution, raised $5.6m in funding.
360Learning, a Paris, France-based learning engagement platform where leaders and learners connect and collaborate to create a continuous work and learning environment, secured a $41m Series B funding.
ExplORer Surgical, a Chicago, IL-based provider of a surgical software platform, received $5M in financing.
Pavlov Media, a Champaign, IL-based provider of broadband services to multifamily real estate owners, acquired Simplified Technologies, a Champaign, Illinois-based provider of IT support services to commercial businesses in the Midwest.
moneycorp, the London, UK-based foreign exchange, international payments, and FX risk management provider, has appointed Bob Dowd as CEO North America.
Alsid, a Paris, France-based Active Directory protection solution provider, raised €13m in Series A funding.
Anzu Partners, a venture capital and private equity firm that invests in breakthrough industrial technologies, launched and held the first closing of its second fund, at over $110m..


text:
Q: Is there a single word for reasoned action? I'm looking for a single word which means "a well thought out action".
In other words, if someone were to plan something carefully, and act on that plan.
For example, a general faces an intractable foe on the battlefield, but thinks carefully on the solution and then acts - defeating the opponent easily. What could we call the action?
N.B. While interesting, I'm not really looking for words which imply "underhanded" or "risky".

A: Stratagem:

an artifice or trick in war for deceiving and outwitting the enemy.

(Source: Merriam-Webster)

A: Strategy
A careful plan or method.
Another option:
Gambit
A planned series of moves at the open of a chess game
A calculated remark intended to start a conversation or make a point
A calculated move
(Definitions from Merriam Webster)
Edit: adding another
Rout
An overwhelming defeat - or to defeat overwhelmingly

A: Consider maneuver:

A planned and regulated action (often military);an adroit move,
  skillful proceeding, etc., especially as characterized by craftiness;

A: tactic

An action calculated to achieve an end. FOD
An action or strategy carefully planned to achieve a specific end. ODO
An action or method that is planned and used to achieve a particular goal. M-W

A: Methodical might work:

methodical
adjective me·thod·i·cal \mə-ˈthä-di-kəl\
: done by using a careful and organized procedure
: working in a very careful and organized way

A: A single word which means: a well thought out action carefully planed and then acted upon, culminating in an outcome, would be a resolution.
resolution, noun

the action of solving a problem, dispute, or contentious matter. –Google
the act of finding an answer or solution to a conflict, problem, etc. : the act of resolving something | the act or process of resolving –MW

A: Usually, when referring to the carrying-out of a complex plan, or series of actions, we use the word: implementation.
"The implementation of the final phase of 'Project Brainwash', must be seamless."

redpajama_set_name: RedPajamaStackExchange


New experience with the convenience unlike any existing!!
Bluetooth cable is the latest amazing product to be released by Belcat. BTC-7 makes your playing easy with your favorite songs with Bluetooth function.
Easy use and simple design!


Public parking for commercial vehicles is among the priorities of the I-10 Corridor Coalition, which Arizona, California, Texas and New Mexico founded in 2016 to find ways to make travel safer and more efficient along I-10. Texas applied for and was awarded the grant on behalf of all four states.
The $6.8 million Advanced Transportation and Congestion Management Technologies Deployment grant from the Federal Highway Administration requires a 50% match by the four states.
The I-10 Corridor Coalition will use the funding to implement a truck parking availability detection and information dissemination system at 37 public truck parking locations along I-10 from California to Texas. The system will make real-time truck parking information available to truck drivers and dispatchers to assist them in making informed parking decisions.
FHWA's ATCMTD program funds early deployments of cutting-edge technologies that can serve as national models to improve travel for commuters and businesses. It was established under the Fixing America's Surface Transportation (FAST) Act. State departments of transportation, local governments, transit agencies, metropolitan planning organizations, and other eligible entities were invited to apply under the program.


This brief exercise will familiarize you with finding details regarding E. coli fermentation.
Transcription-unit page for transcription unit pflB.
Genome browser focused on pflB to view genomic context.
Comparative genome browser with the pflB in the center. Mouse over the pflB gene to bring up the protein name and the pathway where it operates, i.e., mixed acid fermentation.
Pathway page for mixed acid fermentation. By mousing over the diagram you can show the individual reactions of the pathway.
Reaction page pyruvate formate lyase reaction.
Compound page for coenzyme A.
From the Tools menu at the top of the page, click on Regulatory Overview to display a regulatory network diagram for E. coli. This diagram can also be magnified. Right click on your mouse and call up "Highlight Genes by Name or Frame ID. Enter "Fnr".
Mouse over Fnr until you see a square, then right click on your mouse and choose "Highlight Gene fnr and its Direct Regulatees" to call up genes that are regulated by Fnr. The highlighting can be removed by right clicking the mouse away from Fnr and choosing "Clear All Highlighting". Explore which genes regulate transcription of Fnr in a similar manner.
Let's now look at information for another organism, Bacteroides vulgatus. You can switch the current organism that BioCyc queries by clicking on the blue "change organism database" link in the upper-right corner of every page. In the "Quick Search" box enter "mixed acid fermentation" to see whether the genome of this bacterium contains the pathway. You are now directed to the mixed acid fermentation pathway in BioCyc and can explore this pathway and its regulation if data are available.


EP Battery Pack Safety Data Sheet Emerging Power, Inc. Page 1 of 5 Emerging Power Battery Pack Safety Data Sheet Emerging Power offers custom designed portable power solutions as well as a series of standardsized battery packs for various applications including OEM, Government Agencies, Military, Aerospace and Industrial as well as aftermarket customers.
Emerging Power also provides off the shelf solutions including raw cells (all chemistries), View and Download KODAK SC4 operating instructions online. 4 Cell Smart Charger. SC4 Battery Charger pdf manual download.
conguration for the power outlet. This. battery charger is intended to be correctly. oriented in a vertical or oor mount position. Overall I have to recommend the Sony BCG34HRMF4 over this Emerging Power unit for any use! OLD REVIEW: This is my first Amazon product review, but I feel that this battery charger is worth it. I do tech support within a small office and we use AA and AAA batteries constantly.
The one drawback on my model (EPSC) is the switch on the Power tool manuals and free pdf instructions. Find the user manual you need for your tools and more at ManualsOnline. Find helpful customer reviews and review ratings for Emerging Power EPSC4 2 HR AAAAA NiMH Charger at Amazon. com. Read honest and View full Emerging Power battery charger specs on CNET. Emerging Power battery charger NiMH x 4 overview and full product specs on CNET.


text:
New York & Boston
Raices Profundas was founded in 1975 by Juan de Dios Ramos Morejon, as a small collective for cultural investigation and creative presentation of the dances, music and folkloric traditions of the Caribbean. Their first performances were in a community art center or "House of Culture" in Central Havana. In the years that followed, they performed in other "houses of culture" and public squares when invited.
In 1980, they became professionally recognized as a Company, and created a strong repertoire including all of different genres of dance and music in Cuban folklore. They started performing in important theaters and hotels to great acclaim. Their popularity grew, and they also appeared in television shows and films.
Their name "Raices Profundas" literally translates to "Deep Roots". Their founding statement says: "Our group considers itself the heir of these traditions therefore we propose to make ourselves the vehicles to carry on this artistic fortune and cultural flow, promoting the knowledge and its renewal and spreading it throughout our country and….putting our shared cultural treasures on the world's stage, representing Cuba through the universal language of art."
The members of his company train intensively 5 days a week, 4 hours per day when they are not touring, and they work as much as 8 hours per day when they are in performing seasons. Director Juan de Dios explains that he selects his dancers not by their body type nor their physical condition, not by the amount of schooling they have had…instead he chooses people who he can see have the dance in their hearts and souls. He says that many of his dancers just came in from the streets, but that if he can see that passion in them, he doesn't mind training them from scratch.
Their repertory includes:
Cuban Urban Folklore: Songs & Rhythms of Abakua, Yoruba, Arara, Palo, Iyesa, Tumba Francesa, Fandango de Trinidad, Rumba, Claves, Carnaval
Cuban Rural Folklore: Rumba de Campo, Caringa, Zapateo
Haitian Folklore: Gaga, Vudu
Cuban Popular Dances: Son, Danzon, Mambo, Cha cha cha, Casino….. and their signature Chancleta! (Traditional Cuban slipper "clogging" dance)
The full Company includes:
Artistic Director & Choreographer, Juan de Dios Ramos
6 staff members for Administration, Production, and other functions
8 folkloric percussionists
3 folkloric vocalists
24 dancers (12 couples)
They join forces with a 12-member orchestra when performing traditional and popular music live
Their International Tours have included:


text:
"Viterbi vs. Pandemics!" Lecture 1: Modeling Epidemics
Marc Ballon | September 30, 2020
Inaugural lecture in 10-part series focuses on modeling epidemics as a chemical reaction process
(Art/Shutianyi Li)
This fall, and following the National Academy of Engineering's (NAE) Call to Action for engineers to "crowdsource and collectively brainstorm engineering solutions for the coronavirus disease (COVID-19)," Yannis Yortsos, dean of the USC Viterbi School of Engineering and a member of the executive committee of the Call to Action, launched the first installment of "Viterbi vs. Pandemics!" This new lecture series by USC Viterbi faculty comprehensively provides an engineering-centric framework for addressing and understanding the COVID-19 pandemic.
During the 10-week, free program, students will gain exposure to myriad topics, ranging from the estimation of risk and protein engineering by directed evolution to the contributions made by computer science and electrical engineering faculty in automating human safety technologies, detecting misinformation and digital contact tracing. The one- to two-hour sessions, which take place Thursdays at 6 p.m., will extend until November 12.
"We believe that we have made some novel contributions to how the epidemic spreads that provide new insights and can help arrest the contagion," Yortsos said.
On Sept. 10, Yortsos and Assad Oberai, Hughes Professor of Aerospace and Mechanical Engineering, joined forces in the inaugural lecture: "Modeling Epidemics As a Chemical Reaction Process."
The following is a Q&A with Dean Yortsos.
For those who missed it, can you briefly summarize your lecture for a general audience?
Yannis C. Yortsos, dean of the USC Viterbi School of Engineering (Photo/Courtesy of USC Viterbi)
YY: It provides a novel, predictive model for the spreading of human-to-human contagious diseases, such as COVID-19. The model is based on rigorous analogies with those involved in chemical reaction processes.
Why is this research important? How will it help in the fight against COVID?
YY: Current models do not account for one of the most important aspects in the spread of COVID, which is spatial density. In addition, they assume that populations are spaced equally and also that they do not diffuse. Our model accounts for both these crucial effects and allows one to differentiate regions, areas or domains based on their spatial density of populations, as well as to predict the emergence of contagion waves that propagate from one region to another. The predictive nature of the model provides a rigorous setting for the development of more accurate health policies.
How would you compare your research to similar research or ideas, either in academia or industry?
YY: Our work improves in a most substantial way the SIR model, which is the gold standard in the modeling of epidemics since it was first published almost 100 years ago.
What are the next steps and/or milestones in terms of your work?
YY: The next task is to provide methodologies to extract quantitative information on the key parameter, as well as on the elusive concept of "herd immunity" from existing data.
Tell us about your collaborators. What unique skills does each person bring? Are you partnering with any doctors, clinicians or other non-engineers in this work?
YY: The work was done by engineers (faculty and a Ph.D. student). We have shared our findings with other colleagues, both engineers and non-engineers.
Can you share one story from your pandemic life? How has it impacted your work and family? What are you doing to stay sane?
YY: Zooming is an occupational hazard! Watch out for your neck muscles.
From a research perspective, what do you consider the most surprising or counter intuitive aspect of the virus or the pandemic as a whole?
YY: The most crucial contributor to the spreading of epidemics, like COVID-19, is the general public's lack of intuitive understanding of the nature of exponential growth. Humans tend to extrapolate on a straight line. But epidemics grow exponentially. This means that unless the public takes very serious measures early on, the epidemic will inevitably spread. Likewise, the tendency for people to relax when the epidemic appears to have ebbed inevitably brings another contagion wave. Both these are counter-intuitive.
What are some words of wisdom regarding the pandemic that have meant a lot to you?
YY: Pandemics are a human-to-human issue and therefore require human-to-human cooperation for their suppression. This is truly a public issue requiring public cooperation.
Related Paper: A COMPREHENSIVE SPATIAL-TEMPORAL INFECTION MODEL
Viterbi School
"Viterbi vs. Pandemics!" Lecture 7: Vaccine Development
Zohrab A. Kaprielian fellow in Engineering and Professor of Chemical Engineering and Materials Science and Biomedical Engineering Pin Wang discussed immunology behind the COVID-19 vaccine.
"Viterbi vs. Pandemics!" Lecture 3: Biology and Disinfection for COVID-19
Professor Andrea Armani, the Ray Irani Chair in Chemical Engineering and Materials Science, discusses new approaches to sterilizing medical equipment to meet urgent needs during the pandemic.
USC Viterbi Offers Two New Short Courses: "Viterbi vs. Pandemics!" and "Sustainable Energy"
Both lecture series launch the week after Labor Day, offering students a comprehensive faculty coverage of COVID-19 and a series on sustainable energy with Dean Yortsos


text:
At My Age is an album by Nick Lowe released in June 2007 by Proper Records.  It was recorded in London and produced by Nick Lowe and Neil Brockbank.

Track listing
All tracks composed by Nick Lowe except where noted.
"A Better Man" – 2:16
"Long Limbed Girl" – 2:52
"I Trained Her to Love Me" (Lowe, Robert Treherne) – 2:59
"The Club" – 2:36
"Hope for Us All" – 3:42
"People Change" – 2:55
"The Man in Love" (Charlie Feathers, Quinton Claunch, William Cantrell) – 2:08
"Love's Got a Lot to Answer For" – 3:02
"Rome Wasn't Built in a Day" – 2:42
"Not Too Long Ago" (Joe Stampley, Merle Kilgore) – 2:20
"The Other Side of the Coin" – 2:47
"Feel Again" (Faron Young) – 2:48

Personnel

Musicians
Nick Lowe – lead vocals, rhythm guitar, electric bass
Robert Treherne – drums, backing vocals
Geraint Watkins – organ, piano
Steve Donnelly – lead guitar
Matt Radford – double bass
Matt Holland – trumpet, flugelhorn, piano solo on "People Change"
Martin Winning – tenor saxophone, clarinet
Bill Kirchen – 6-string bass on "The Club"
Chris Barber – trombone on "The Other Side Of The Coin"
Chrissie Hynde – backing vocals on "People Change"
Neil Brockbank – Vox organ on "The Club" and "People Change"
Bob Loveday – violin and viola on "People Change", "Rome" and "Feel Again"
Linnea Svensson – backing vocals on "Hope For Us All"
Anna Harvey – backing vocals on "Feel Again"
Nick Payne – baritone saxophone on "Rome" and "Not Too Long Ago"

Production
Produced by Nick Lowe, Neil Brockbank
Recorded at Goldtop Studio, Chalk Farm, London and RAK Studio, St John's Wood, London
Phil Hankinson - cover illustration

Charts
Sweden-10

References

External links

2007 albums
Nick Lowe albums
Albums produced by Nick Lowe
Proper Records albums
Yep Roc Records albums


text:
No Park Service Review of Welcome Center
J. Paul Loether, Chief, National Register of Historic Places and National Historic Landmarks, wrote on Wednesday, September 3, 2014, "the implementation of the current proposal of the Preservation Society of Newport County to construct a new visitors center within the boundaries of The Breakers NHL does not require approval by the National Park Service (NPS)." Click here to read the correspondence.
RIHPHC Affirms Its Approval of Welcome Center Project
In a letter dated October 2, 2013, the RI Historical Preservation and Heritage Commission has affirmed its July vote approving the Preservation Society's plan for a new welcome center at The Breakers. In direct contradiction of an opinion by Newport Historic District Commission staff, the RIHPHC states that the plan is in compliance with the Secretary of the Interior's Standards and National Park Service Guidelines, and will not alter the historic character of The Breakers.
Click here to read the full decision
Construction of a new welcome center at The Breakers to provide basic amenities for its 400,000 annual visitors from around the world is a major priority of The Preservation Society of Newport County's Board of Trustees. The revenue generated by those visitors goes directly toward restoration and preservation projects at The Breakers and the Preservation Society's other historic properties. In these short video clips, trustees Alice Ross and William Wood Prince talk about why they support the welcome center, and why it is critical to the future of sustainability of the Preservation Society:
Many others in the Newport community have expressed their support for the Preservation Society's plan to build a new welcome center at The Breakers.
You can see more videos here.
Below are excerpts from some of the letters that have been submitted to local newspapers and to the Historic District Commission. You may read the entire text of each letter by clicking on the link.
Marcel Valois, Executive Director, Rhode Island Economic Development Corporation
"After a decade of work, the Preservation Society's Board of Trustees has selected a design that meets sound historic preservation criteria, while providing for the comfort and orientation needs of visitors. With this new welcome center, the Preservation Society will be able to meet the world-class standards of hospitality expected at internationally recognized historic sites, while positioning its properties to generate more visitor revenue in the state."
Click here to read Mr. Valois's full letter
Trudy and Lew Keen, Newport residents
"The Preservation Society has invested more time, utilized more manpower and applied more expertise on this project than anyone. it best understands the needs and challenges of operating The Breakers as a major historic site....
We trust that the project as presented by the Preservation Society will be in the best interest of the Breakers property. We trust the Preservation Society of Newport County, and it has earned the trust of all of us."
Click here to read Mr. and Mrs. Keen's full letter
Mark Stenning, CEO, International Tennis Hall of Fame & Museum
"The Preservation Society of Newport County is fully committed to ensuring that the Welcome Center be done with the utmost care and be constructed in a way that complements the historic property and adheres to the highest level of historic preservation guidelines....
At the International Tennis Hall of Fame & Museum we strive to provide an environment that is aesthetically pleasing, comfortable, and accessible and represents the highest level of hospitality for our visitors....A Welcome Center on The Breakers property would allow for the Preservation Society of Newport County to do the same, and for the good of our entire community, I fully support this proposed project."
Click here to read Mr. Stenning's full letter
Guillaume de Ramel, Newport
"I am a longstanding member and supporter of the Preservation Society. I believe wholeheartedly in the vital importance of this project, based on my profound admiration of the Preservation Society and its mission to preserve, protect and present the exceptional collection of properties and landscapes in its care....
"The Welcome Center will treat our visitors with the dignity, respect and comfort they deserve. The building will be beautiful and appropriate to the magnificent setting, the landscapes renewed to make Ernest W. Bowditch proud, and the amenities offered to our visitors modest, convenient and efficient."
Click here to read Mr. de Ramel's full letter
Lawrence S. Cutler, AIA, Chairman and Co-Founder, National Museum of American Illustration, Newport
"I hope that HDC will accept this bright and shining light just as The RI Historical Preservation & Heritage Commission agreed this project is laudable and should progress.
I am in favor of the PSNC plans for the Visitors Center at The Breakers. The proposed scheme indicates a superbly designed structure appropriate to both PSNC and user needs. It is appropriately sited, and does not interfere in any meaningful manner with the existing historic structures or the existing landscape."
Click here to read Mr. Cutler's full letter
Stephen C. Waluk, former Mayor of Newport
""This strikes me as a pivotal moment for the future of Newport. The city's cultural institutions are the lifeblood of the community. Such investment is visionary. And it is necessary--not only for the PSNC--but for the city as well. My time in office helped me recognize that change can have a positive impact and that we as a city can evolve without diminishing the value of our historic treasures."
Click here to read Mr. Waluk's full letter
Valerie Talmage, Executive Director, Preserve Rhode Island
"Newport's District Ordinance is designed to protect historic assets and guide new growth. Historic District Zoning in genera, and Newport's Ordinance in particular, are established knowing that change will be introduced into historic areas....Nowhere does Newport's Ordinance prohibit change--instead it seeks to guide change in ways to protect and enhance the remarkable historic character of the City."
Click here to read Ms. Talmage's full letter
J. Timothy O'Reilly, Chairman, Newport Harbor Corporation:
"....Having spent a career in Newport's visitor/tourism economy, I am concerned that virtually all of the opponents of this proposed amenity who have identified themselves are either not local residents, or are individuals who do not depend on the local economy for their family's economic livelihood....
As to the red herring that local restaurateurs fear the 'competition' from box lunches at the Breakers visitors center, it is simply not true. There have been box lunches available at The Elms and the Chinese Tea House for the past few years, and no restaurateurs have objected...
Let the Preservation Society implement a very thoughtful plan that has been vetted by nationally and locally recognized historical preservation authorities...."
Click here to read Mr. O'Reilly's full letter
Richard Sardella, former Mayor of Newport
"As a former Mayor of Newport and a long-time restauranteur, I have followed the discussion over the Preservation Society's plans to build a welcome center at The Breakers.
The need for the building is clear, and I am confident that the Society and its team of experts have identified the best location. The Breakers is no longer a single family residence. It is one of our State's iconic and most visited treasures, and the hundreds of thousands of annual visitors need and deserve a better reception than the one currently provided."
Click here to read Mr. Sardella's full letter
Eric Hertfelder, former Deputy State Preservation Officer
"The proposed replacement for the current visitor center is a reasonable approach given contemporary standards and the high volume of visitation at the site...."
"I believe the replacement of the current visitor center with the proposed new visitor center...will not adversely affect the significant historic features of The Breakers as documented in the National Historic Landmark designation of the property."
Click here to read Mr. Hertfelder's full letter
Nicholas Brown, former Navy Captain, Director Emeritus of the National Aquarium in Baltimore and former Executive Director of Preserve Rhode Island:
"....Changing to meet the exigencies of the times is indeed adaptive reuse, the heart of modern historic preservation. It is that principle which doubtless persuaded the Rhode Island Historical Preservation and Heritage Commission, the highest authority on historic preservation in the state, to give its approval to the society's proposal....
To me as a retired museum and historic preservation professional, the functions performed by the proposed welcome center are absolutely non-negotiable. You must ticket, you must provide toilets and refreshment, and you fail in your mission if you do not provide orientation. Further, when dealing with a Gilded Age experience, what you provide must have class...."
Click here to read Capt. Brown's full letter
Jody Sullivan, Executive Director, Newport County Chamber of Commerce
"The Breakers welcome center proposal by the board of the Preservation Society of Newport County is a well thought-out and planned project that has consistently reached out to the local business and restaurant community to ensure that any concerns were addressed.
By any hospitality standards, the Preservation Society's current amenities hardly deserve the name. The proposal to upgrade them is overdue. As one of the top 10 historic houses in America by attendance, it needs to and deserves to be able to provide visitors with a comfortable experience. Newport is a world-class destination and needs to be able to offer our visitors a world-class experience....
What has been proven by the current welcome facilities is that given a chance to understand all that Newport has to offer, visitors will spend more and more time here. That translates into more attractions added to the itinerary, more dinners served, more nights in lodging and a tremendous economic driver to our local economy...."
Click here read to read Ms. Sullivan's full letter
William J. Corcoran, Newport
"....Currently the welcome center consists of a tent (with no air conditioning) and a toilet trailer. The Preservation Society of Newport County plans to replace this tent and toilet trailer with a beautifully designed and cleverly concealed structure that will enhance the visitor experience and provide first-class restroom facilities for the 400,000 visitors who come to The Breakers each year. the plans for this welcome center have been painstakingly made to be as tasteful, elegant and invisible as possible while still providing a first-class experience to visitors.
....Remember, not all change is bad. There was violent opposition to the building of the Eiffel Tower, the Washington Monument and the Flatiron Building, all of which became icons for their cities. The new welcome center at The Breakers is so beautiful that it too can achieve icon status while also providing a world-class tourist experience. Let's give positive change a chance."
Click here to read Mr. Corcoran's full letter
Evan Smith, President and CEO, Discover Newport
"Change in our world is inevitable; it is how we change that is critical to building a better tomorrow....The Preservation Society has reached out to many community stakeholders in a very thoughtful manner to gather feedback about how to best develop the design and functionality for the dynamic new center; I've had the opportunity to evaluate the inspiring architectural plans designed by Epstein Joslin Architects and Reed Hilderbrand Landscape Architects. It is evident the Preservation Society and these two experienced firms have brought together key elements in terms of site location, business function, the visitor experience and aesthetic style, resulting in a decidedly attractive design.
Many historic homes across America have invested wisely in new interactive welcome centers that serve visitors well without compromising the integrity of the site. Thomas Jefferson's Monticello in Charlottesville, VA; George Washington's Mount Vernon Estate in Alexandria, VA; and Springwood, the home of Franklin D. Roosevelt in Hyde Park, NY are just some examples of treasured historic sites (and National Historic Landmarks) that merge 21st century visitor expectations with a sensitivity to the communities in which they exist."
Click here to read Mr. Smith's full letter
Laurie Z. Stroll, President, Newport Hospitality Inc.
"I think the Preservation Society of Newport County should be commended for the proposed welcome center at The Breakers. It has done a fine job of researching and exploring every option and has come up with a plan that is tasteful and functional. The landscaping has been designed to envelop the building so that it will be hardly seen. The most important viewing point, standing at the gates, will have a clear, unobstructed view of The Breakers in front of you.
....I trust that the Preservation Society would not do anything to jeopardize the historic integrity of its own precious mansions and landscaping. As shown in the presentation, the original historic character of the landscaping has been lost over the years from hurricane damage and original plantings becoming overgrown. This well-designed plan creates a welcome center and rehabilitates a beautiful landscaping at the same time."
Click here to read Ms. Stroll's full letter
Martha J. Sheridan, President & CEO, Providence-Warwick Convention and Visitor Bureau
"As someone who worked as a tourism professional in Newport and throughout Rhode Island, I am very familiar with the care the Preservation Society takes in managing its affairs and its properties. It is always conscious of its impact on the city, and consistently looks for ways to partner, and be a good neighbor. Its work is vital to the economic health of Newport and the state of RI."
Click here to read Ms. Sheridan's full letter
David C. DePetrillo
"As a former Director of Tourism for Rhode Island, it was my privilege to work closely with the Society for many years. I have always been impressed by the caring and professional stewardship that its leaders and staff have shown for its collection of amazing architectural and cultural treasures. That's why I was nor surprised when I saw the superb design of its proposed welcome center and the way it was so carefully sited on the grounds of The Breakers."
Click here to read Mr. DePetrillo's full letter
Barbara Behan Howlett, President, Glorious Affairs Catering
"My company has worked with the Preservation Society for many years....The new Welcome Center will provide an environment for the visitors that is comfortable, safe, attractive and assimilates with the historic nature of the local surroundings. As a small local business owner who relies on the seasonal visitors, we see this development as a natural evolution for Newport that will improve the experience for our visitors and provide a platform to increase business and provide employment opportunities for Newport."
Click here to read Ms. Howlett's full letter
David M. Hart, architect
"During my work at the Preservation Society of Newport County I became quite familiar with the Breakers property, having examined the interior, exterior and grounds, and having climbed and examined the roof surfaces. The proposed Visitors Center addressed many much needed services at the Breakers complex...More importantly, in my opinion, it meets the Secretary of the Interior's Standards for Rehabilitation and Guidelines for Rehabilitation of Historic Properties...."
Click here to read Mr. Hart's full letter
You can show your support for The Breakers Welcome Center plan by liking our page on Facebook:
https://www.facebook.com/SaveTheBreakersNewport