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Jo Litson: Scene and Heard
Articles and reviews about the performing arts in Sydney – and occasionally beyond.
Tag Archives: Sabryna Te'o
Love's Labour's Lost and The Importance of Being Earnest
Posted on January 4, 2016 by jolitson
Bella Vista Farm, December 12
Lara Schwerdt, Emily Eskell, Sabryna Te'o and Madeleine Jones in Love's Labour's Lost. Photo: Maryne Rothe
Sport for Jove's outdoor season is always something to look forward to during the Sydney summer (weather permitting) and this year's production of Love's Labour's Lost is a delight.
I saw the play at Bella Vista Farm Park in the Hills Shire and have been tardy in reviewing it so that season is now over. However, you can catch the production at Everglades Gardens in Leura during January – and it's well worth it.
At Bella Vista Farm, Sport for Jove has a new purpose-built stage. With a lighting rig and backstage area, it is better equipped for the cast and crew. Constructed at the bottom of a gently sloping hill, it also provides better sightlines for the audience who can either sit on a picnic blanket, or a little further up the hill on provided plastic chairs. The set-up may not have quite the same charm as when the company performed in a courtyard in front of the farmhouse or in the nearby shed, but it is eminently practical.
What's more, the set (co-designed by Damien Ryan and Anna Gardiner) is vibrantly attractive in a shabby chic kind of way with wisteria-draped screens and walls and a "marble" floor: a staging that sits well and looks good in the outdoor setting under Sian James-Holland's lighting.
Love's Labour's Lost is one of Shakespeare's early, rarely performed comedies. It's a wordy piece though it never feels cumbersomely so here. In his program notes, director Damien Ryan writes that he has removed the play's "most impenetrable material" but admits that some of the language remains "a curiously knotted garden". However, there's lots of wonderful poetry and the production rollicks along with such an infectious energy that any difficult language never becomes an issue.
The plot is light and rather silly. The young King Ferdinand of Navarre (Edmund Lembke-Hogan) and his friends Lord Biron (Tim Walter), Dumain (Curtis Fernandez) and Longaville (Gabrielle Scawthorn) take a pledge to avoid woman and wine for three years and instead devote themselves to study.
But before the ink is dry, the Princess of France (Emily Eskell) and her ladies-in-waiting Rosaline (Sabryna Te'o), Maria (Lara Schwerdt) and Katherine (Madeleine Jones) arrive and test their resolve.
A second plot involves a Spanish nobleman, Don Adriano de Armado (Berynn Schwerdt) who is bent on wooing a comely country maid called Jaquenetta (Claire Lovering). A bumpkin called Costard (George Banders) is also sweet on Jaquenette but is no match for the Don and finds himself being used at the go-between for one and all.
The women in the play are highly spirited and independent, and while attracted to the men refuse to become their playthings. As a way to increase the number of roles for women, Ryan has Longaville played by a woman in masculine attire (Scawthorn) who holds her own in the privileged men's world. By doing so, Ryan introduces the issue of marriage equality. The device works brilliantly, without feeling at all gimmicky. When the young people eventually pair off, there just happens to be one lesbian couple.
Edmund Lembke-Hogan, Curtis Fernandez, Tim Walter and Gabrielle Scawthorn in Love's Labour's Lost. Photo: Marnya Rothe
While using Elizabethan costuming, Ryan also injects a great deal of fun by portraying the officious, bureaucratic Anthony Dull (Scott Sheridan) as a contemporary park ranger.
Speaking of costuming, Melanie Liertz has done an exceptional job on the smell of an oily rag. Apparently the women's gowns are made from painted canvas. Amazing.
Ryan's cast is terrific. Some handle the language better than others, but overall it's performed with a zest that fills the air, sailing effortlessly to the top of the hill. Beryn Schwerdt is hilarious as Don Adriano, flouncing around in melodramatic fashion with a fruity, comedic Spanish accent to match.
Aaron Tsindos is also funny as the Don's manservant Moth. Scawthorn is impressive as Longaville, Lembke-Hogan exudes confident poise as Navarre and Walter is dashing as the serious, cynical Biron. But all the cast – which also includes Wendy Strehlow and James Lugton – are on song. A fun night.
The evening begins with a short curtain raiser: Josh Lawson's Shakespearealism, a clever, 30-minute send-up about Ralph Shakespeare, a young playwright who pioneered realism on stage but lived forever in the shadow of his brother William. Directed by Lizzie Schebesta, with Lembke-Hogan as Ralph, James Lugton as jaded theatre manager Philip Henslowe, and Scawhtorn and Tsindos as two actors, it's a cute piece but makes for a long night.
Deborah Kennedy as Lady Bracknell and Scott Sheridan as Jack Worthing. Photo: Marnya Rothe
Oscar Wilde's The Importance of Being Earnest is one of the greatest comedies of all time, but I'm not sure that the play with its witty repartee and drawing room settings lends itself to an outdoor production in the same way that Shakespeare does. Damien Ryan directs an enjoyable enough production but it often feels a bit try-hard in the comedy stakes. The slapstick routine of Algernon (Aaron Tsindos) and his manservant Lane (James Lugton) falling off the stage doesn't sit right in Wilde's stylish world, nor does Cecily (Eloise Winestock) gagging on the name Algernon. What's more, I didn't find any of that particularly funny.
Some of the gags work well – the running joke about the servant's bell is amusing – but the portrayals of the gun-toting Cecily and hyper Gwendolen (Claire Lovering) feel far too overplayed.
Deborah Kennedy has the style absolutely right as Lady Bracknell and nails every laugh, delivering the famous lines as if they've never been said before in a standout performance. Wendy Strehlow is also on the money with Miss Prism, while Tsindos has the measure of the witty, devil-may-care Algernon.
Love's Labour's Lost and The Importance of Being Earnest, Everglades Gardens, Leura, January 9 – 24. Bookings: http://www.sportforjove.com.au
Posted in Theatre	| Tagged Aaron Tsindos, Anna Gardiner, Berynn Schwerdt, Claire Lovering, Damien Ryan, Deborah Kennedy, Edmund Lembke-Hogan, Eloise Winestock, Emily Eskell, Gabrielle Scawthorn, George Banders, James Lugton, Lara Schwerdt, Lizzie Schebesta, Madeleine Jones, Melanie Liertz, Sabryna Te'o, Scott Sheridan, Sian James-Holland, Tim Walter, Wendy Strehlow	| Leave a reply
Caress/Ache
Posted on March 6, 2015 by jolitson
Griffin Theatre Company, SBW Stables Theatre, March 4
Ian Stenlake. Photo: Brett Boardman
Caress/Ache, a new play by Australian playwright Suzie Miller, was inspired initially by the 2005 execution of young Australian drug trafficker Nguyen Tuong Van in Singapore. Under Singaporean law, his mother was not allowed to hug him before his death.
The shocking inhumanity of such a ruling set Miller thinking about the importance and power of touch. The result is Caress/Ache, a play, which went through a long period of studio development at London's National Theatre. In her program notes, Miller also acknowledges the dramaturgy of a number of highly regarded theatre professionals. And yet, after so much work, the play – which now has its premiere at Griffin Theatre Company – still lacks the emotional depth to rise above its all-too-obvious exploration of a chosen subject and truly resonate.
Miller interweaves a number of stories. There's Mark (Ian Stenlake), a paediatric doctor who feels like a god when he is saving children's lives. Even the sex with his wife Libby (Helen Christinson) is better after a successful operation. However, when he loses a young patient on the operating table, he can no longer bear to touch his wife or be touched.
Mark later turns to a phone sex line, speaking to Cate (Sabryna Te'o), a single mother who is working there to support her child, asking her to touch her face and arm and describe the sensation. Cate is new to the job, taught how to handle things (as it were) by her cheery, experienced colleague Belinda (Zoe Carides), who lends the fairly heavy piece a little levity.
Then there's the furious Saskia who confronts her poet boyfriend Cameron (Gary Clementson), after discovering he has slept with her boss. We also meet Arezu (Te'o), a young Iranian woman whose parents fled to Australia to give her a better life, naming their daughter after the word for "hope". But Arezu is frustrated that they won't talk about Iran. When her uncle gives her a book of Farsi poetry, she starts to wear the hijab and decides to return to her homeland to discover who she really is.
Her story is less linked to the all-pervasive theme of touch, but at the airport she meets Saskia who is flying to London. In a brief encounter, Arezu ends up giving the unhappy Saskia a hug – a moment that feels utterly contrived. There's another tenuous connection between Cate, Cameron and Saskia via an autistic child, which comes out of nowhere and really does feel as if Miller is straining things unnecessarily.
Finally, there's Alice (Carides) who goes to Singapore to be with her son Peter (Clementson) who is about to be hanged there for drug trafficking only to find she isn't allowed to touch or hold him. Mark is the Australian doctor/coroner who will be at Peter's execution and complete the paperwork afterwards.
This particular story strand leads to the powerful closing scenes and the play's undeniably moving final image. However, it was impossible to watch this without thinking of what is happening in Indonesia. On the very day of the play's opening, Andrew Chan and Myuran Sukumaran were transferred from Bali's Kerobokan Prison to the island of Nusakambangan to await their execution for drug trafficking.
For some, the extraordinary timing heightened the emotion and lent the play an added power, with a number of audience members in tears at the end of the play. Others – myself included – found it extremely uncomfortable. Clearly, Miller could have had no idea when she was writing the play of how closely it would be reflecting newspaper headlines. Had the preceding scenes been dramatically stronger, it might not have mattered. As it was, I found those particular scenes uncomfortably close to emotional manipulation, giving the play a resonance it hadn't earned.
Directed by Anthony Skuse, the Griffin production is staged on a stark white set designed by Sophie Fletcher, which begins as a hospital operating theatre and then allows for quick, simple changes for different locations.
As the start of the play, a quote is projected onto the theatre walls: "Human skin and tissues contain millions of sensory receptors. Without them, there would be no capacity for people to sense the touch of another."
Various statements and statistics relating to touch are flashed up periodically throughout the play. In the end, they just get in the way, reinforcing the feeling of a lecture. And therein lies the problem with the play. It always seems to be illustrating its chosen topic, rather than organically exploring it. The characters exist only to fit the theme. They don't feel real, lacking a convincing emotional life beyond what they represent here in relation to touch.
Gary Clementson and Helen Christinson as Saskia and Cameron. Photo: Brett Boardman
The dialogue between Saskia and Cameron feels particularly clichéd, causing some sniggers on opening night as he mutters about feeling disgusted with himself, while she can't believe he could do this to her. ("Tell me it didn't happen, Please just tell me you didn't do this.") The way she goes on and on, furiously demanding more and more graphic details about his infidelities makes her come across as a victim, wallowing in his betrayal, while he hangs his head in shame but perpetuates his lies.
The opening scene in which Mark rhapsodises about his feelings when he is operating uses a heightened, poetic language. He rolls along the top of the metal bench as in a piece of choreographed physical theatre, while music swells. But this style of performance is just as suddenly dropped, apart perhaps from a bath scene featuring Saskia and Cameron.
And why, when Mark's marriage has obviously been a loving one, would he not at least try to explain to Libby why he now shrinks from her? Instead he silently turns his back. As for Nate Edmondson's music, sung by the cast, it feels overblown and sits oddly stylistically.
Skuse has the actors play things at full bore. The five performers turn in strong performances, but the play resists their attempts to give it a convincing emotional life. Instead Caress/Ache speaks to us "about" a theme. What's more, it doesn't have anything particularly new to say in relation to it.
The fact that a mother can't hold her son before he is executed is a truly terrible thought. You can see why it would capture Miller's imagination. She has clearly done a huge amount of research into the subject of touch and all that it involves but she hasn't found a way to synthesise this into a genuine drama.
Caress/Ache runs at the SBW Stables until April 11. Bookings: griffintheatre.com.au or 02 9361 3817
Posted in Theatre	| Tagged Anthony Skuse, Gary Clementson, Griffin Theatre Company, Helen Christinson, Ian Stenlake, Nate Edmondson, Sabryna Te'o, Sophie Fletcher, Suzie Miller, Zoe Carides	| Leave a reply
The Chimney Sweep
Posted on July 7, 2014 by jolitson
City Recital Hall, July 5
Stuart Haycock and Amelia Farrugia. Photo: Keith Saunders
The surtitles before the start of The Chimney Sweep announce the restoration of Salieri's reputation – and Pinchgut Opera certainly does him proud with this delightful production.
Most people these days would only know Antonio Salieri's name from the 1984 Academy Award-winning film in which he was depicted as a mediocre composer who poisoned his fierce rival Mozart out of jealousy.
In truth, Salieri was more famous in his day than Mozart and almost certainly did not murder him. But where Mozart is now one of the most performed composers in the world, Salieri's music is rarely heard.
Thanks to Pinchgut – which dedicates itself to the presentation of rarely seen operas from the 17th and 18th centuries – Sydneysiders have the chance to see the Australian premiere of Salieri's comic work The Chimney Sweep (Der Rauchfangkehrer). A huge hit when it was first staged in 1781, it all but disappeared after the mid-1800s.
The Chimney Sweep is a rollicking comedy centring on Volpino, a musically gifted chimney sweep who is in love with Lisel, a cook in the household of wealthy widow Mrs Hawk and her stepdaughter Miss Hawk.
Learning that Mr Bear and Mr Wolf have won the lottery and hope to marry the Hawks, Volpino and Liesel cook up a plan to better themselves financially.
Pretending to be an Italian count disguised as a sweep, Volpino uses his musical skills to worm his way into the affections of the Hawks who he then auctions off to Wolf and Bear. From there it spins off into all kinds of comic complications – but as you'd expect it all ends happily.
Right from the start of the overture you can hear the fun in Salieri's music, emphasised by a quick little leap of joy by Erin Helyard, who conducts the marvellous Orchestra of the Antipodes. The music doesn't compare to Mozart's operas (though it is often reminiscent of Mozart) but much of it is lovely and thoroughly enjoyable.
Written as a singspiel in which the musical numbers alternate with dialogue, Pinchgut performs it in English. Director Mark Gaal has translated the dialogue, while Andrew Johnston has translated the lyrics. Both have done a great job. Occasional phrases like "My god, they go ballistic" had the audience chuckling but the translations aren't so tricksy that they compromise the original 18th century setting.
Gaal has staged a simple but effective production with gorgeous costumes and set by Emma Kingsbury. Performed against a gold wooden backdrop with a huge gargoyle-faced fireplace, and just a few props, Gaal uses signs (flamboyantly displayed by Gary Clementson as the servant Hansel) to announce each new location.
The performers all handle the dialogue and dramatic challenges extremely well, playing the comedy to the hilt, while the ladies really shine vocally. Amelia Farrugia is outstanding as Mrs Hawk and young soprano Janet Todd is also very impressive as Miss Hawk. Together they steal the show.
Stuart Haycock has a fairly light tenor voice but brings plenty of charisma to the role of Volpino. There is strong support from David Woloszko as Mr Bear, Christopher Saunders as Mr Wolf, Alexandra Oomens as Lisel and David Hidden as the master chimney sweep Tomaso, as well as Clementson, Nicholas Hiatt, Troy Honeysett and Sabyrna Te'o as the servants. The Sydney Children's Choir makes up the cast as Tomaso's young apprentices.
Overall, The Chimney Sweep is lots of fun and yet another feather in Pinchgut's already well-covered cap.
The Chimney Sweep has its final performance tonight. Bookings: www.cityrecitalhall.com or 02 8256 2222
Posted in Opera	| Tagged Alexandra Oomens, Amelia Farrugia, Andrew Johnston, Antonio Salieri, Christopher Saunders, David Hidden, David Woloszko, Emma Kingsbury, Erin Helyard, Gary Clementson, Janet Todd, Mark Gaal, Nicholas Hiatt, Orchestra of the Antipodes, Pinchgut Opera, Sabryna Te'o, Stuart Haycock, Sydney Children's Choir, Troy Honeysett	| Leave a reply
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Build Your SaaS – bootstrapping in 2019 | Listen Free on Castbox.
Taylor Otwell: "PHP (and a cheap laptop) changed my life"
Also: have you signed up for your app with your own credit card?
Do startups need specialists or generalists?
Did we solve our bandwidth cost crisis?
Is this the best time to start a podcasting startup?
You mentioned Castbox in this episode, so I thought I'd try it.
Some folks have responded to this episode, wanting us to talk more about the total size of the market. We'll get into that in the future!
Of you've ever wondered about conversion rates, this one's for you!
"The money is bored" - this still gets me!
Most folks underestimate the importance of building anticipation *before* a launch!
Agreed! Paul Graham (from YC) has riffed on this a bunch too.
I think the founder of Airbnb said that you have to start with something that doesn't scale to perfect the customer experience, before scaling. I think you're on the right track there!
Love the show, love the candid insights and journey! For all of us out here burning our midnight oil and building our dreams.
A great story with play-by-play updates as founders build a SaaS business. It's honest and candid, with real insights. As a founder myself I'd certainly recommend it.
If you're building a web startup in 2018, this show is for you!


Andy woke up cold. He had used his sleeping bag as a quilt and the temperature dropped too much during the night for it to be comfortable.
There was an upside though. Being cold helped us start moving earlier than the previous two mornings.
We hiked out of camp wearing our fleeces at 6:40 am, an entire 40 minutes later than our campmates Toaster and Smudge, but over 30 minutes sooner than our departures the last two days.
We walked through the foggy, cold forest waiting for our hands to warm up. This looked and felt like the Washington we were expecting.
The trees moaned and squeaked in the wind as we walked by. At times we thought we heard children yelling or bears growling – but no – it was just the trees.
We got to Forest Road 23 just before 11 am. Toaster and Smudge were lying down on the side of the road.
They had been waiting for over 20 minutes and only 1 car had passed.
So we joined them on the side of the highway.
Andy walked down the road and found service near a pullout. After 4 months on the trail we have learned to spot places with potential service.
There must have been times when he's gotten calls only to drive out there to find no hikers.
Thirty minutes after we placed the call Doug pulled up.
There were already two hikers in his van. Jackson and Dave had resorted to walking the 14 miles into town after waiting for awhile with no luck. Thankfully they didn't have to walk too far.
We all piled in and headed down the twisty mountain road, trying to get glimses of Mt. Adams through the dark, stormy clouds.
Doug dropped us off at the General Store where Toaster and Smudge had reserved a room and where we had sent our resupply boxes.
We too inquired about a room but they had no availability. Having our hearts still set on staying at Trout Lake Abbey, Laurie called them once again. We finally got in touch with someone who told us to try calling again between 1 and 1:30 when someone would be in the office.
Ok. We can be patient. Well, Andy can. And Laurie can distract herself. We decided to distract ourselves with food.
We have a tendency of waiting too long to eat in towns often becoming hangry. We decided to be proactive to break this habit so we walked over to the cafe after picking up our resupoly boxes.
As we walked towards the entrance we noticed a familiar face, Slingblade, sitting at one of the picnic tables finishing a BLT. After he told us about the scary river crossings we avoided north of Tuolumne Meadows and his hiking plans for the summer, we parted ways once again.
Juat after ordering, Toaster and Smudge joined us. We all scarfed down burgers and fries. Laurie even got a gluten free bun!
As we ate a woman from the table next to ours came over, inquiring about our hike. She told us her daughter is hiking a section of the PCT and should arrive in Trout Lake the following week.
We told her we were thinking of going to the Abbey to see about a room and they offered to drive us there. Yay!
After treating us to a huckleberry milkshake, Toaster and Smudge returned to their room at the General Store and we drove 10 minutes south of town. We entered Trout Lake Abbey and were caught off guard by its beauty.
Lush green grass, a labyrinth, a Buddhist temple, an organic farm, chickens, alpacas – this place was paradise!
Susan greeted us and informed us that they had hostel beds available. We went inside, looked at the empty room that can sleep 8 and chose to stay.
There are hostels and then there is this place.
"How come this place isn't more popular?" We wondered.
We were grateful to have this room all to ourselves. We spread out like we usually do when in town, but it was hard to get anything done. We kept getting distracted by the views.
Eventually we came up with a game plan. Andy went to pay for our beds and to do laundry while Laurie backflushed our filters.
Around 4pm Susan gave us a tour of the property. The details are what make this place unique.
The iron work, the labrynth, the clay building, the small bungalows, the alpaca, the sunflowers, the just-picked blueberries and tomatoes, and on and on.
We really, really considered taking a zero. Our bodies weren't tired or sore but it was so nice we didn't want to leave. After looking at the weather and the area of Washington we are heading into we reconsidered.
The Goat Rocks Wilderness and Knife's Edge are about 50 miles from where we left the trail. We have a good weather window and wanted to make the most of it!
Kozen Sampson – monk and co-owner of the Abbey – arranged for an employee to take us back to the trail after breakfast.
We can't thank the staff here enough. They've treated us very well and welcomed us with warm hearts.
We enjoyed dinner in our room while watching the alpenglow on Mt Adams.
Although it's been a hectic day, we don't feel as stressed as we typically do in town. Must be the setting!
Tonight we are grateful for 23 acre farms that welcome hikers and cell service in the middle of nowhere.


It's great to be ending the year on a high with workmen back on site at the new Royal.
As you may have seen in recent media coverage, we were able to take TV cameras behind the scenes to witness some of the work that management contractor Laing O'Rourke are currently undertaking. These tasks and others are part of the necessary preparatory works ahead of beginning the revised construction programme. It was also a pleasure to welcome MP Louise Ellman and Metro Mayor Steve Rotheram to the site and thank them, along with Joe Anderson, Mayor of Liverpool and other local politicians, our staff and supporters, for everything they have done to get to where we are today.
We are currently working with Laing O'Rourke through the procurement process with around 140 contractors who were previously employed on the site, to get construction completed as soon as possible.
Going into the New Year we will see work start to accelerate, in line with Laing O'Rourke's construction programme and we expect the new Royal to be handed over to us by the end of 2020.
You may have also seen recent media coverage on our bed capacity and bed numbers. These reports, (based on winter situation reports published by NHS England) suggested that the Trust was operating at 100% capacity throughout the first week in December. This wasn't the case, like most trusts across the country, we were operating at high levels of capacity, but it was not 100% and we continued to provide beds for patients that needed them.
Reports also suggested that there were around 100 fewer beds across the Trust this year than last year. This too was incorrect.
I can clarify that last year we had 802 beds. This included 11 'escalation' beds used to help manage increased demand, which had been kept in use from the previous winter. Last year we used an additional 34 'escalation' beds, bringing the total last year to 834.
This year we had 791 beds open prior to winter and opened 24 escalation beds in the first week of December. As part of our plans to manage increased demands on our service we plan to open a total of 48 beds, meaning we will have 839 open beds this year, which is 4 more beds, not 100 fewer beds, than last year.
We have reviewed our internal processes with our business intelligence and operational teams to understand how this incorrect data came to be published in the winter situation reports. Going forward we have strengthened our review of this data set prior to it being submitted.
Reports also speculated on bed numbers in the new Royal and how we will manage capacity when we move in. I'd like to reassure you that we have a detailed plan for how we will manage our bed numbers for moving into the new Royal. This involves increasing bed numbers at Broadgreen Hospital, moving some services to specialist centres close by and providing care more efficiently, to reduce the demand on our beds.
So whilst the new Royal will have 646 beds, together with Broadgreen Hospital we expect to have around the same number of beds across the Trust as we currently have. We are confident that our plans, together with programmes to increase capacity for community based care, will provide sufficient capacity by the time we move into the new Royal.
In January, BBC Two's Hospital documentary series is set to air. The programme will showcase some of the hard work of our staff and local colleagues, and also highlight some of the challenges that we have had to overcome this year.
As we bring 2018 to a close and get set to welcome 2019 we can look forward to renewed optimism. I'd like to thank you all for supporting us throughout 2018 and I wish you all a Merry Christmas and a Happy New Year!


text:
Q: How to release the GIL in Cython for a multithreaded C++ class? I have a C++ class with some methods that use std::thread that I'm making accessible to Python via Cython. Do you know where in my Cython code I'd want to put the nogill directive? Would I want to put it when I declare the class methods or when I create a Cython wrapper class? I've used the example class from the Cython docs below:
Declaring the class:
cdef extern from "Rectangle.h" namespace "shapes":
    cdef cppclass Rectangle:
        Rectangle() except +
        Rectangle(int, int, int, int) except +
        int x0, y0, x1, y1
        int getArea()
        void getSize(int* width, int* height)
        void move(int, int)

Cython wrapper class:
cdef class PyRectangle:
    cdef Rectangle c_rect      # hold a C++ instance which we're wrapping
    def __cinit__(self, int x0, int y0, int x1, int y1):
        self.c_rect = Rectangle(x0, y0, x1, y1)
    def get_area(self):
        return self.c_rect.getArea()
    def get_size(self):
        cdef int width, height
        self.c_rect.getSize(&width, &height)
        return width, height
    def move(self, dx, dy):
        self.c_rect.move(dx, dy)

A: You probably don't actually need to use nogil. The GIL only stops multiple Python threads being run simulatenously. However, given you're using C++ threads they can quite happily run in the background irrespective of the GIL, provided they don't try to use PyObjects or run Python code. So my suspicion is that you've misunderstood the GIL and you can get away with not thinking about it.
However, assuming that you do actually want to release it, you need to do 2 things:

*

*Mark the C++ functions as nogil to tell Cython that they don't need the GIL. Note that this doesn't actually release it - it just lets Cython know it isn't a problem if it is released:
cdef cppclass Rectange:
   Rectangle(int, int, int, int) nogil except +
   int getArea() nogil
   # ...

*Use with nogil: blocks in your Cython wrapper class to mark the areas where the GIL is actually released.
cdef class PyRectangle:
    # ...
    def __cinit__(self, int x0, int y0, int x1, int y1):
        with nogil:
            self.c_rect = Rectangle(x0, y0, x1, y1)
    def get_area(self):
        cdef int result
        with nogil:
            result = self.c_rect.getArea()
        return result

get_area becomes slightly more complicated since the return statement can't exist inside the with nogil block since it involves generating a Python object.

redpajama_set_name: RedPajamaStackExchange


text:
time to talk
Sexting poses legal, psychological risks for teens
Young people are increasingly engaging in riskier online behaviors
Deputy Jay Martin teaches a Y.E.S.S. class at a Douglas County high school. The program is a partnership between the school district and the Douglas County Sheriff's Office.
Posted Tuesday, April 24, 2018 4:09 pm
Alex DeWind
adewind@coloradocommunitymedia.com
When Douglas County Deputy Jay Martin first started teaching about relationships, digital safety and substance abuse prevention, maybe one high school student in each of his classes would raise his or her hand when asked who had participated in sexting.
"Now, over half my class is raising their hands," said Martin, an instructor in the Y.E.S.S., Youth, Education and Safety in Schools, program, created in 2009 by the Douglas County School District and the Douglas County Sheriff's Office to educate students and parents on substance abuse, teen relationships and internet safety.
With access to infinite online content, research shows young people are engaging in riskier behaviors such as sexting, the act of sending or receiving sexually explicit messages or nude photos through text messages and on other digital devices.
In a report published in April by JAMA Pediatrics, a peer-reviewed medical journal, authors studied 110,380 participants under 18 years old. The average age was 15. Results revealed 14.8 percent had sent a sext, 27.4 percent had received a sext, 12 percent had forwarded a sext without consent and 8.4 percent had a sext forwarded without consent.
Mental health experts say that exposing young people to sexually explicit images can skew their perception of healthy intimacy and relationships. Educators in Douglas County have seen that some teens are becoming desensitized to sexting.
They think "sending and receiving nude photos is no big deal," Martin said.
Many young people are unaware of the repercussions of sexting. In Colorado, sexting among juveniles can be a Class 1 misdemeanor charge with a possible sentence of six months in jail, a $500 fine or both; a Class 2 misdemeanor, which carries a minimum sentence of three months in jail, a $250 fine or both; a civil infraction, which requires participation in an educational program; or a petty offense, which differs depending on the charge but could include jail time or a fine. In some extreme cases, a juvenile may have to register as a sex offender.
"Legally, that is considered child pornography," said Apryl Alexander, clinical assistant professor at the University of Denver Graduate School of Professional Psychology, of cases that involve aggravating factors. "Kids are being arrested and going on a sex-offender registry from taking a picture and sending it."
Teen sexting was a controversial topic during last year's state legislative session, when lawmakers introduced a bill that would lessen the penalties of sexting, which used to be considered sexual exploitation of a child, a felony that carries a jail sentence, fine or both, and requires registration as a sex offender. The new law gives prosecutors the discretion to decide where a case fits.
The law followed controversial cases of sexting in Colorado that left prosecutors with just two options: a felony charge or no charge. In 2015, police found hundreds of nude photos shared between students at a high school in Cañon City, southwest of Colorado Springs. The students involved weren't charged with anything because investigators found no "aggravating" factors, including any adult involvement, coercion, bullying or posting of pictures to the internet, multiple news outlets reported at the time.
Alexander, who has worked with adolescents who engage in sexting, encourages parents to monitor and talk about kids' social media use. She recommends using www.connectsafely.org, a website that details the latest apps and social media trends.
"Some of those apps are becoming a little more risky," said Alexander. "But all the sites in general have some risk of some vulnerability with these younger children."
Time to Talk, Alex DeWind, sexting, teen sexuality, apps,
Jeffco Commissioners approve rezoning for 353-unit development in Golden
Arapahoe County gives over $2 million to nonprofits
Englewood selects remediation contractor following discovery of more meth contamination
Small goalie makes big impact on ice
As the opposing team grabs the puck and skates down the ice in a breakaway, parents and fans of the Arapahoe Warriors 10U Yellow team, or Golden Eagles, take a collective breath. As the goalie falls on the puck to secure the save, parents scream, "Good job, Emma."
Lawmakers want to eliminate all carbon emissions by 2050
One of the boldest climate change and air pollution bills set for debate in the legislature this year would attempt to eliminate all of Colorado's carbon emissions by 2050, set tough interim goals …
Denver bought one-way bus tickets for 1,900 migrants
Denver spent nearly a half-million dollars last month buying one-way Greyhound bus tickets to other cities for 1,900 migrants who arrived here after crossing the U.S. southern border, according to …
School closures coming as enrollment dips again
Enrollment in Colorado public schools took another dip this school year, setting up reduced funding for districts across the state and raising the threat of further school closures. The problems — …

redpajama_set_name: RedPajamaCommonCrawl


The Automobile Engineering Department of Dr. Sudhir Chandra Sur Degree Engineering College organized a session with the JIS Group - Ashok Leyland Skill Development Centre at the college premises on 30th August, 2018 for the B. Tech students.
The students got a marvelous opportunity of Industry Exposure by undergoing the training session of few latest developments of Ashok Leyland as well as global automotive market. They also got introduced with INNOLINE Engine of Ashok Leyland, iEGR and SCR Technologies, working of a Neptune Engine driven by electrical power source. This exposure will help them to understand the link between the theoretical & practical concepts.The students got a marvelous opportunity of Industry Exposure by undergoing the training session of few latest developments of Ashok Leyland as well as global automotive market. They also got introduced with INNOLINE Engine of Ashok Leyland, iEGR and SCR Technologies, working of a Neptune Engine driven by electrical power source. This exposure will help them to understand the link between the theoretical & practical concepts.


Rich in ideas, vivid in execution, Yarn forms a delightful fabric that takes time to unravel.
It's been interesting watching Grid Iron add an explicitly political dimension to their output over the past couple of years, much of it gleaned from extensive work in the Middle East. . .classic Grid Iron with an edge, ripping through layers of human artifice to get to the heart of the matter. They wear it well, on their sleeves and everywhere else.
there's something heroic about Ben Harrison's Grid Iron company, and their sustained attempt- via site-specific shows- to explore the world of true sensual delight and passion. . .Yarn is a wholly charming series of reflections on the role of clothes and fabrics in human history, sexuality and identity. . .what's attractive about Yarn is its imaginative attempt to engage with Dundee as a textile town, to evoke a deeper understanding of its past. It also features a bracing sense of internationalism. And it has a gloriously eclectic finale, co-staged with Janet Smith of Scottish Dance Theatre, that races like a thing possessed through an eccentric world history of cloth and its abuses. . .glamorous, allusive, thought-provoking.
Ben Harrison's direction and incredible technical team ensure that like 'Roam' before it, Yarn is one of those rare productions which hits the balance between being entertaining and thought-provoking just right.
Grid Iron delivers an impressive array of narrative threads with which to weave together its stories.
Each superb soliloquy casts light on a memory- or experience- involving a garment, releasing feelings of anger, envy, regret, lust. . .the diverse politics of clothes is a major thread throughout incorporating the use of clever puppetry. This is an outstanding production, delivered by a brilliant cast. . .the audience is lead seamlessly, an ongoing fascination holding the pieces together generating a truly unforgettable theatrical experience Dundee audiences should grab with both hands.


text:
module CanvasStatsd
  class BlockStat

    attr_accessor :stats
    attr_accessor :common_key

    def initialize(common_key, statsd=CanvasStatsd::Statsd)
      self.common_key = common_key
      @statsd = statsd
      @stats = {}
    end

    def subtract_exclusives(stats)
      @exclusives ||= {}
      stats.each do |(key, value)|
        @exclusives[key] ||= 0.0
        @exclusives[key] += value
      end
    end

    def exclusive_stats
      return nil unless @exclusives
      stats.map { |key, value| [key, value - (@exclusives[key] || 0.0)] }.to_h
    end

    def report
      if common_key
        stats.each do |(key, value)|
          @statsd.timing("#{common_key}.#{key}", value)
        end
        exclusive_stats&.each do |(key, value)|
          @statsd.timing("#{common_key}.exclusive.#{key}", value)
        end
      end
    end
  end
end

redpajama_set_name: RedPajamaGithub


text:
Satterwhite and Hamilton complete Buddy Stephens' EMCC football coaching staff
Published 9:04 am Tuesday, July 5, 2022
By Special to the Item
SCOOBA – East Mississippi Community College head football coach Buddy Stephens has completed his 2022 coaching staff with the hiring of former University of West Alabama quarterback Harry Satterwhite and former Troy University assistant coach Webb Hamilton.
A native of Mobile, Ala., Satterwhite will primarily coach EMCC's quarterbacks after having spent the past two seasons as a graduate assistant coach at the University of South Alabama. Hamilton, a Starkville Academy product and Mississippi State graduate, returns to the Scooba campus to work with the Lions' linebacker corps as he did on EMCC's 2013 national championship team that featured arguably the NJCAA's most dominant defense.
Satterwhite exploded onto the collegiate scene during his junior year at UWA as one of 10 finalists for the 2017 Harlon Hill Award – the NJCAA Division II equivalent to the Heisman Trophy. While setting single-season school records for most passing yards (3,421) and pass completion percentage (.651) along with most pass completions (322) and attempts (495), Satterwhite was named the Alabama Sports Writers Small College Athlete of the Year. In guiding head coach Brett Gilliland's 10-3 Tigers to their first outright conference championship in five years and a quarterfinal-round appearance in the 2017 NCAA Division II playoffs, Satterwhite was named to the All-Gulf South Conference First Team and earned honorable mention status on the Don Hansen NCAA Division II All-American Team.
As a graduate student and second-year permanent team captain the following year, Satterwhite completed 233-of-394 passes for 2,663 yards and 25 touchdowns in directing the 8-4 UWA Tigers to a second straight NCAA Division II playoff appearance.
"I am very thankful for Coach (Buddy) Stephens hiring me on staff here at EMCC and having an opportunity to get better as a coach by working with the quarterbacks," Satterwhite said. "I am eager to get started working with the guys and continuing the winning tradition that's been established here in Scooba."
A prep standout at Mobile's McGill-Toolen Catholic High School, Satterwhite completed his playing career at West Alabama ranked second on the school's all-time lists with 7,450 career passing yards and 67 touchdowns thrown. He is also UWA's all-time leader in career pass completions (677) and attempts (1,106).
Hamilton returns to East Mississippi following an eight-year hiatus that saw him spend five years (2014-18) at Troy and most recently serve coaching stints at Navarro College in Texas and Petal (Miss.) High School. He coached linebackers and special teams at Navarro, where the Bulldogs won the 2019 Southwest Junior College Football Conference championship and current Marshall University standout linebacker Abraham Beauplan ranked second among the NJCAA ranks in total tackles.
"I'm extremely thankful to Coach (Buddy) Stephens for bringing me back on board here at EMCC. Some of my fondest memories as a coach came during our national championship run in 2013," Hamilton noted. "It's great to be back, and I look forward to helping to continue the championship tradition here in Scooba."
While at Troy working with current West Virginia head coach Neal Brown and WVU defensive coordinator Jordan Lesley, Hamilton transitioned from a graduate assistant coach to serving as a senior football analyst. During Troy's successful three-year span between 2016 and 2018 as one of the top teams in the Sun Belt Conference, the Trojans were a collective 31-8 overall and 20-4 league play with three straight postseason bowl game victories.
During Hamilton's previous season in Scooba, he worked primarily with EMCC's outside linebackers under Lesley's guidance. The 2013 EMCC Lions, featuring current NFL defensive line veterans Jarran Reed and D.J. Jones, went undefeated in allowing an average of less than 10 points per contest, including five shutouts, on the way to claiming the first of back-to-back NJCAA championships.
Hamilton is married to the former Mallory Madison of Philadelphia, Miss. They have a son, Sims, who was born in October 2021.
Blue Devils Brayson Kirby selected for 2023 all-star game
Fields, Dawson named Bulldogs of the Week
Basketball: Picayune remains undefeated, Lady Hornets clinch win and Lady Blue Devils loss three straight
PRC smothers Picayune to advance to South State Championship


Pac-Attack for Super Nintendo is the combination of both Pac Man and Tetris. Blocks of various sizes drop from the top of the screen, and you have to arrange them to form even lines. There are different play modes to mix the action up a little, and there are 100 different levels in all.


text:
Mainly clear. Low 21F. Winds WNW at 5 to 10 mph..
Mainly clear. Low 21F. Winds WNW at 5 to 10 mph.
Mystic Aquarium, ARSOME announce 'Animal Heroes' subscription box
From Mystic Aquarium
MYSTIC, Conn. - Mystic Aquarium is excited to announce the upcoming launch of 'Animal Heroes,' a one-of-a-kind monthly subscription box that will call on youth to give back to the planet. The Aquarium's world-class educational programming and ARSOME Technology Group's powerful immersive technology have joined forces to create a one-of-a-kind Educational Experience. This incredible educational tool offers grade-school students the chance to become heroes for our planet by discovering how they can help preserve wildlife, conserve natural resources, and give back to the earth through interactive games, videos, and unique outdoor activities and challenges.
An Animal Heroes subscription offers children and families an exciting way to stay connected through learning, calls on youth to give back to the planet and supports Mystic Aquarium's conservation- focused mission.
Powered by Connecticut-based software developers ARSOME Technology Group, the 'Animal Heroes' monthly subscription box includes a diverse suite of digital content as well as a variety of hands-on activities. Users can customize their own 'Animal Heroes' avatar, test their knowledge with fun facts and quizzes, tackle conservation challenges, and interact with the physical world using augmented reality features in the 'Animal Heroes' app. Additional outdoor activities help 'Animal Heroes' practice conservation in their own backyard.
"We at ARSOME are absolutely thrilled with the opportunity to partner with Mystic Aquarium," said Benjamin D. Williams, Co-Founder and CEO. "We believe the 'Animal Heroes' subscription box will demonstrate how families can actively engage, experience, and enjoy the education and entertainment benefits as children and families continue to look for new and creative ways to immerse themselves in technology."
Each month the box will be themed around a featured animal, including African penguins, beluga whales, sharks and sea turtles. The amazing digital technology is complemented by fun 'hero gear,' including stuffed animals, trading cards, adoption certificates, and much more.
The 'Animal Heroes' subscription box, a thoughtful, educational, fun and 'good for the Earth' gift will be available for purchase in mid-December, just in time for holiday gift giving.
For more information on how to join the 'Animal Heroes' mission and become an ambassador for the planet, sign up for updates at https://www.mysticaquarium.org/animal-heroes/.


text:
Deniz Selek (* 1967 in Hannover) ist eine deutsch-türkische Schriftstellerin.

Leben
Selek verbrachte ihre ersten drei Lebensjahre in Istanbul. Sie studierte Germanistik, Pädagogik sowie Innenarchitektur und arbeitete vor ihrer ersten Veröffentlichung als Künstlerin, Schuhverkäuferin, Flugbegleiterin, Thekenfrau, Texterin, Redakteurin und Illustratorin.

Selek lebt mit ihrer Familie in Berlin.

Tätigkeit als Autorin
Ihre Erstlingsveröffentlichung Zimtküsse (2012, S.Fischer Verlag) wurde auf der "Radio Bremen Kinder- und Jugendbuchliste Herbst 2012" empfohlen, Kika und das ZDF-Morgenmagazin wiesen auf den Roman als "Buchtipp" hin. Zimtküsse stand 2013 auf Platz 2 des deutsch-französischen Jugendbuchpreises. Das Fachmagazin Bücher rezensierte das Werk. Beim LovelyBooks Leserpreis belegte Zimtküsse in der Sparte Kinder- und Jugendbuch den 32. Platz. 2013 las Selek auf der Lit.Cologne aus ihrem Buch.

Ab 2014 erschien mit "Kismet" eine neue dreibändige Jugendbuch-Reihe ebenfalls im S.Fischer Verlag, um die Deutsch-Türkin Jannah und ihre chaotische deutsch-türkisch-afrikanische Patchworkfamilie. Darin verliebt sich Jannah in ihren Stiefbruder.

2015 erschien mit "Aprikosensommer" das fünfte Jugendbuch der Autorin im S.Fischer Verlag, in dem sich die Heldin Eve auf die Suche nach ihrem unbekannten türkischen Vater macht.

2016 wurde mit *Die Frauen vom Meer Selek's erster Roman für Erwachsene im Droemer-Knaur Verlag München veröffentlicht. Der Mehrgenerationen-Roman über das Schicksal dreier Frauen beginnt 1920 in Rumänien, geht über in die neue türkische Republik, beleuchtet eine Nachkriegskindheit und Jugend in Deutschland und reicht bis in die heutige Zeit. *Die Frauen vom Meer basiert auf wahren Begebenheiten. Der Roman wurde 2017 für den Evangelischen Buchpreis und den Delia-Buchpreis vorgeschlagen.

Mit *Die Farben im Spiegel, 2017 ebenfalls bei Droemer-Knaur Verlag München, erschien das siebte Werk und der zweite Roman der Autorin für Erwachsene. Selek beschreibt darin die lebenslange Liebe zweier Menschen, deren Mütter Deutsche und deren Väter Türken sind.

Werke
 Zimtküsse. S. Fischer Verlag, Frankfurt 2012, ISBN 978-3-596-85460-8.
 Kismet – Oliven bei Vollmond. S. Fischer Verlag, Frankfurt 2013, ISBN 978-3-596-81072-7.
 Kismet – Köfte in Flipflops. S. Fischer Verlag, Frankfurt 2014, ISBN 978-3-596-81168-7.
 Aprikosensommer. S. Fischer Verlag, Frankfurt 2015, ISBN 978-3-7335-0066-5.
 Kismet – Couscous mit Herzklopfen. S. Fischer Verlag, Frankfurt 2016, ISBN 978-3-596-81169-4.

 Die Frauen vom Meer. Droemer-Knaur Verlag, München 2016, ISBN 978-3-426-30615-4.
 Die Farben im Spiegel. Droemer-Knaur Verlag, München 2017, ISBN 978-3-426-30575-1.

Weblinks
 Persönliche Website

 Steckbrief beim RBB

Einzelnachweise

Autor
Illustrator (Deutschland)
Jugendliteratur
Literatur (Deutsch)
Schriftsteller (Berlin)
Deutscher
Türke
Geboren 1967
Frau

redpajama_set_name: RedPajamaWikipedia


Bjerkeflåta Camping is situated along route 40, by the intersection for Rjukan and Imingfjell. We sell fishing permits for Uvdalselva and Laagenvassdraget, the two main rivers in the area. The camp site is only a short distance away from areas of great natural beauty, such as Dagalifjell and Imingfjell, the gateways to Hardangervidda. Uvdal Alpine Resort and Uvdal Alpine Park are both only a short drive away.
There is a small supermarket nextdoor to the campsite with a selection of groceries.


Based on a pre-defined weighted trend formula for chart analysis, MOSC.U scored +80 on a scale from -100 (strong downtrend) to +100 (strong uptrend).
Want to analyze Mosaic Acquisition Corp Units MOSC.U or another symbol? Try our Free Stock Trend Analysis Report.


Some applications, such as those relating to strata titles disputes for example, may be dealt with on the documents, without a hearing or a final hearing.
For example, with Commercial Tenancy matters, specifically section 13(7) applications, there is sufficient information in the application and the contract documents that are provided with the application for a SAT member to make a determination on the documents provided and issue an order.
In other matters, the application may have had a number of hearings and there is sufficient information and evidence for the member to consider the matter and make a final order. Where these final orders are made without a hearing they are referred to as a decision on the documents.


As one of sixteen Myers-Briggs types, the INFJ is introverted (I), intuitive (N), feeling (F), and judging (J). A little different from the ISFP—who shares the introverted (I) and feeling (F) traits but not the intuitive (N) and judging (J) traits.
Both have a need for some privacy to collect themselves and regroup. If the INFJ says to an ISFP partner, "I think I'll go out and straighten up the garage," the ISFP is likely to interpret this as a need for time alone and say "Good idea," rather than "Want me to come?" Or, if the ISFP heads outside with watercolors and paintbrush, the INFJ probably won't offer to tag along. They both treasure their private space.
Their feeling (F) function makes them sensitive to each other's needs—another Myers-Briggs trait they share. In fact, they base most of their personal decisions upon the impact they'll have on others. Before making any large purchases, accepting invitations, or making important choices, they consult their partners.
Their shared traits of introversion (I) and feeling (F) make them understand each other's tendency to be shy. They realize that both are too critical of themselves, tending to undervalue their skills. The positive aspect of this is that they can offer mutual reassurance.
An important difference between the INFJ and ISFP lies in their intuitive/sensing (I/S) functions. Intuitive types rely on their hunches to make decisions. They don't take in all the details that the sensing person does, but they can draw sound conclusions without them. The sensing type has a watchful eye and misses nothing. In their world, decisions should be based on facts, not hunches.
The couple's differences in perceiving (P) and judging (J) can sometimes cause friction because the INFJ makes decisions more impulsively than the methodical ISFP. Perceiving (P) types like to postpone closure as long as possible, being more comfortable with open-ended situations.
Unless the INFJ appreciates the ISFP's need to keep decisions open-ended until the last minute—and until the ISFP understands the INFJ's impatience for closure—they may be in for some frustrating moments. Because of their judging (J) function, INFJs rarely miss deadlines and are always on time for appointments. ISFPs, as perceivers (P), are inclined to make deadlines by the skin of their teeth and be anywhere from five to thirty minutes late for social events.
Falling in love is a major event for both INFJs and ISFPs. In the first stages of an affair, they're seldom separated, immersing themselves in each other's company. If the relationship continues, they're usually loyal partners. One may even change careers or relocate for the good of the partnership.
INFJs and ISFPs are good at entertaining each other with their wide-ranging interests and taste for adventure. Together they make take up new activities such as camping, art, or gourmet cooking. Of the two, the ISFP is inclined to be more graceful and athletic because they enjoy the feeling of their bodies in motion. They often excel at physical activities requiring both sensitivity and strength, such as dancing and figure skating.
The main problems that INFJs and ISFPs face usually stem from their tendency to avoid disagreements. They may fail to stand up for or even recognize their own emotional needs. If the air isn't cleared and resentments are allowed to develop, the relationship can be damaged to the point where one or the other strays, looking for a more agreeable partner. This can be devastating for the person left behind, as both types are naturally vulnerable to rejection and prone to self-criticism.
When an INFJ meets an ESTP, some special chemistry must be at work for them to enjoy time together. These Myers-Briggs types are exact opposites.
The INFJ (I) is introverted—a private person. The ESTP (E) is sociable and outgoing. INFJs rely more on intuition (N) than concrete facts to reach conclusions. ESTPs use their sensing (S) function to get information from the immediate environment. INFJs take action based on their feeling (F) function, evaluating the impact of their decisions on others. ESTPs pride themselves on their ability to reach decisions based on logic (T). Finally, INFJs like to bring closure to situations, a judging (J) function. ESTPs like to keep decisions open-ended. They're happy-go-lucky about appointment times and deadlines—unlike INFJs, who arrive places on time and meet their deadlines.
If it's true that opposites attract, that surely must be the case for INFJs and ESTPs.
Introverted (I) INFJs approach friendship in a quiet, thoughtful way. They are comfortable alone or with one or two close friends. ESTPs can be found wherever the action is.
While both types have a sense of humor, INFJs lean toward subtle, dry wit whereas ESTPs paint their humor in broad strokes. Some INFJs find the bluff approach of ESTPs a bit much. ESTPs often find INFJs a little boring. Both types like to laugh, but they find their humor in different places.
The intuitive (N) INFJ observes what's going on—requiring a limited amount of concrete information to guess where events are headed and determine what decisions to make. INFJs rely on hunches. And they're usually on target. They're more interested in the meaning of events than in the events themselves. Sensing (S) ESTPs wonder how their INFJ friends can jump to conclusions based on so little evidence. It seems crazy to them. The fact that the INFJ is often right is an unexplainable mystery.
INFJs are big on romance and physical intimacy. Their introversion, intuition and feeling traits set them up for it. For ESTPs, love has less to do with intimacy than it does with finding a fun partner with whom to share life's adventures.
While the INFJ is cautious in the first stages of a relationship due to fear of rejection, the ESTP is the opposite. Winning an exciting partner is a challenge—in fact, it's one of the main objects of romance. Because ESTPs would rather make romantic moves on the ski slopes than in the bedroom, the INFJ can get disappointed in the relationship. ESTPs are generally not creative or passionate lovers.
Unlike most INFJs, ESTPs are risk takers, whether the risks are physical, financial or intellectual. They're willing to play for high stakes in the hope of high rewards. They especially enjoy looking for loopholes or unusual pay-offs relative to the time or money invested.
To the INFJ, this is foolhardy. The pipe dreams of the ESTP seem risky to the INFJ and frequently the product of poor judgment. In a partnership, this can cause trouble over time. ESTPs tend to lay themselves open to con schemes. INFJs are usually too intuitive to fall for them. The question is, can an INFJ get an ESTP partner to listen?
When a partner ends a relationship, it's a bitter pill for the INFJ to swallow. In contrast, an abandoned ESTP will be unhappy for a while but soon decide that life is too short for grief and sadness. ESTPs know how to cut their losses and face new challenges.
INFJs are enjoyable to live with, offering the family intimacy as well as intellectual stimulation. ESTPs are fun to live with, too, but for different reasons. Their spontaneity keeps things lively and their practical orientation to life makes sure that things get done.
While INFJs have no trouble taking action when it's appropriate, they do think before jumping in. ESTPs are more likely to fly by the seat of their pants. If the family dog escapes from the yard and runs off, the ESTP is in the car immediately, patrolling the neighborhood and calling the dog's name. "Bruno! Bruno! Where are you?" The INFJ, thinking before acting, recalls that Bruno has a doggie friend one block away. Acting on a hunch, he or she calls the neighbor. Sure enough, Bruno is scratching at the chain link fence where his friend stands waiting, tail wagging.
ESTPs know how to anticipate the needs of partners and children when it suits them. Occasionally, though, they're so direct that feelings are hurt when they overlook ordinary courtesies. INFJs may have to overcome their conflict-avoidant style to point this out to the ESTP for the good of everyone involved.
As parents, INFJs and ESTPs work in harmony. Both have realistic expectations of their children. They don't need to see straight A's when report cards come home as long as the children are applying themselves and working toward goals that are productive and make them happy.
INFJs aren't the tidiest people in the world, but they're better than ESTPs, who tend to live in cluttered home environments. That's because ESTPs have so much going on at once—much of it requiring supplies and equipment. However, they may keep certain areas of the house organized enough that they can find the right thing when it's needed. The parts of their home that are orderly usually relate to their hobbies or special interests.
ESTPs often try to talk family members into risk-taking sports such as hang-gliding, white-water rafting, or downhill skiing. They tire of safe domestic routines. Attacking the unpredictable gives them a rush. INFJs aren't as adventurous and may balk at the suggestion of sports that threaten life and limb.
In the intimacy of their partnership, they should realize that a little give and take is in order. INFJs do well to expand their social activities with ESTPs, spending time as a couple with friends and relatives. ESTPs need to pay attention to the emotional needs of the INFJs, at least some of the time.
What happens when an INFJ meets an ESFP? Is there an instant attraction? Do they repel each other like two magnets?
Looking at their personality traits, you'd think they have little in common. When an early attraction persists, it's cause for wonder. Usually, the bond is associated with their shared feeling (F) trait.
The first big difference lies in the INFJ's need for privacy vs. the ESFP's preference for social contact. On the introversion/extraversion (I/E) scale, the inwardly focused nature of INFJs causes them to be reserved and, in extreme cases, reclusive. They dislike crowds and need considerable time alone. They're worn out by prolonged social interaction. In contrast, extraverts are social butterflies. The company of other people energizes them. Being left alone too long makes them feel anxious and disorganized.
To which the INFJ responds, "I can promise you, I'll want to leave early. And I know you. You won't." And so it's likely to go.
The difference in Myers-Briggs traits can be more divisive for the partners in terms of their intuitive (N) vs. sensing traits. The well-developed intuition (N) of INFJs gives them a talent for interpreting the meaning of events around them on limited evidence. Their hunches are usually well-founded. To the sensing (S) ESFP, this makes no sense. ESFPs draw conclusions based on what they see and hear in the immediate environment. They're less concerned about the meaning behind people's actions than they are with the actions themselves.
The ESFP thinks, "What? A ring is a ring! We all know what that means." The INFJ thinks, "Ring? Who cares about the ring? I can tell there's trouble in that relationship." Mostly likely, the INFJ is right.
INFJs and ESFPs are also worlds apart on their perceiving (P) and judging (J) traits, especially if they tend to be at extreme ends of the scales. Perceiving ESFPs are easy-going and fun-loving. If they're a little late for an appointment or miss it entirely, oh well. Manaña is the name of the game. Not for the INFJ. To be late is almost a sin.
When frustrations arise in a relationship, they're often due to P/J differences in the decision-making styles of the two types. ESFPs like to delay decisions until the last possible moment. In their view, there's always more information to be gathered. They're less concerned about bringing decisions to a close than enjoying the ride. INFJs prefer closure. They want to sign the contract and whip out their credit card. They're more interested in reaching their destination than enjoying the scenery along the way. In old Type A—Type B terms, the INFJ is a Type A and the ESFP is a Type B.
When an INFJ/ESFP couple decide to buy a refrigerator, the INFJ goes to the computer, looks up comparative data and prices, and consults Consumer Reports for recommendations. By the time the partners walk out the door the next day to shop, the INFJ has already decided on a refrigerator, including the make and model.
Not so fast, says the partner. We'd better look around. They visit every appliance store in town before sundown, and still the ESFP hasn't made a decision. They'd better go back on Sunday, the ESFP says. The INFJ is going crazy. Before they left the house that morning, the INFJ knew which refrigerator they should buy. He or she would like to wring the partner's neck.
Vive la feeling! At least the two types have this preference in common. Both are concerned with the other's emotional comfort. They're careful of the impact of their words, actions, and decisions upon the other. Both are kind, compassionate people.
Their feeling trait helps them work through the incompatible aspects of their personalities. The ESFP member of the couple is optimistic, playful and fun-loving. Of the two refrigerator shoppers, he or she takes the most outgoing, enthusiastic view of life. The INFJ is more focused and driven. Because they love each other, they make allowances and put effort into getting along and enjoying each other's company. They give each other wiggle room.
The secret of a successful INFJ/ESFP relationship lies in the couple's tolerance, compassion and mutual enjoyment of life together. Their feeling function—their love for each other—is a major factor in the growth and stability of the partnership.
Most of us think we know the difference between introverts and extraverts. Introverts seldom go anywhere, right? They'd rather stay at home and read a book. Extraverts are party animals. Wherever the action is, that's where you'll find them. Introverts don't talk much. Extraverts talk all the time.
To some extent, this is true. But there's much more to it than that.
Introverts don't just find a hole somewhere and sit in it, protected from the outside world. They're recharging their batteries, collecting their thoughts, and getting their feelings organized. When they're in the outside world, they're certainly able to be friendly and talkative some of the time. But after a while they tire out. They need privacy to regroup, think things over, and decide what it all means. If they've been let down by a friend, they want to mull the matter over before talking about it. Not extraverts. Too much time alone makes them antsy. When left in solitude for a long period, they get irritable. They need to talk to other people. It's how they get their energy.
If you send an introvert and an extravert to a party together, you can almost count on the introvert suggesting they leave early and the extravert wanting to stay until the lights are turned out. The difference? The introvert is being depleted of energy. The extravert is recharging.
• Gathers energy from thinking and reflecting in private.
• Needs plenty of time alone.
• When in social settings, comes across as reserved.
• Is drained by prolonged exposure to groups, at work or anywhere else.
• At parties, talks to only two or three people, preferably previous acquaintances.
• Suspicious of people who seem too glib.
• Doesn't reveal personal information readily.
• Dislikes being interrupted while concentrating on something.
• Comes to life in group settings. Mixes easily in crowds.
• Needs the stimulation of social activities to function effectively.
• Knows a lot of people and considers many of them friends.
• Can work and function in noisy, busy settings.
• Isn't distracted by the TV, radio, or conversations of others.
• Tends to dominate conversations, especially with introverts.
• Approaches strangers as easily as friends.
• Discloses personal information readily.
• Needs frequent attention and affirmation from others.
Carl Jung, the Swiss psychoanalyst whose work on personality types opened up the field of personality typology in the early 1900s, introduced the concepts of introversion and extraversion. These ideas were further developed by Isabel Myers and Katherine Briggs, creators of the Myers-Briggs Personality Inventory.
As the words introvert and extravert are used these days, they miss some of the subtleties of the original Jungian terms. Now, people think of introverts as shy, withdrawn people. They think of extraverts as talkative, outgoing types. Jung intended the words to indicate not where a person's actions are invested but the source of their psychological energy.
Extraverts focus their attention on people and events in the external world. Introverts focus on their inner world. As personality preferences, one is no better than the other. Both are simply ways that people construct meaning from their experiences.
It's important to remember that the functions of introversion and extraversion are preferences, not rigid personality characteristics. While introverts may be reserved and quiet most of the time, they're quite capable of being talkative and outgoing when a topic comes up that interests them. The same is true if they're talking with close friends about subjects of mutual interest.
Speaking from personal experience, I have friends who swear that I'm an extravert. They're wrong. Nothing pleases me more than checking my calendar and finding that I have no appointments that day. However, when I do have appointments and they engage my interests, I look like an extravert—outgoing and enthusiastic. What I'm not interested in are meetings devoted solely to social interaction.
Are extraverts always talkative and outgoing? Not necessarily. While they are energized by the company of others and enjoy contributing to conversations, they are capable of being quiet observers. The defining factor is where their attention is focused. Extraverted news reporters, for example, may have little to say while watching and recording a public event. While they are absorbed in filming, recording or taking notes, they may be mostly quiet and observant. As soon as these extraverts have done their jobs, however, they're likely to feel a need to talk with others about what they've witnessed. Introverts, on the other hand, will process the information internally first and talk about it later.


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NASA CLPS Moon landing missions
What is NASA's CLPS program?
NASA is returning humans to the Moon later in the decade, but a fleet of agency-supported robotic spacecraft will start touching down on the lunar soil first.
With its $2.6 billion Commercial Lunar Payloads Services (CLPS) initiative, NASA has been competitively funding commercial companies to build spacecraft that autonomously land on the Moon, and carry with them the agency's science and technology payloads to geologically diverse places.
Render of Firefly's Blue Ghost lander A render of Firefly's Blue Ghost lander descending on the Moon.Image: Firefly
Upcoming CLPS Moon landings
To date, NASA has funded four commercial companies for a total of seven CLPS Moon landing missions between 2022 and 2024 as follows:
Mission 1, Q4 2022: $77 million contract to Intuitive Machines
Mission 2, Q4 2022: $79.5 million contract to Astrobotic (now delayed to 2023)
Mission 3, 2023: $47 million contract to Intuitive Machines
Mission 4, 2024: $93.3 million contract to Firefly
Mission 5, November 2023: $75.9 million contract to Masten Space
Mission 6, November 2024: $226.5 million contract to Astrobotic
Mission 7, 2024: $77.5 million contract to Intuitive Machines
Mission 8, 2025: $73 million contract to Draper
Unlike traditional missions, these CLPS missions will be fully built, operated and managed by their companies, with minimal oversight from NASA. The agency only dictates preferences for the landing sites, and the instruments it wants onboard.
These missions will also have non-NASA payloads from across the globe — something the agency encourages to spur a commercial lunar ecosystem. All landers on these missions will last a maximum of one lunar day — that is, 14 Earth days — since frigid nighttime temperatures, well below -100 degrees Celsius (-148 degrees Fahrenheit), will render the solar- and battery-powered landers non-functional.
Intuitive Machines' first CLPS mission
For its first CLPS mission in late 2022, Intuitive Machines will carry six NASA payloads to Oceanus Procellarum, a dark lava plain on the Moon. Most notably, the lander will have stereo cameras to record how its engine plumes impact the surface. This will help us quantify how rocket plumes interact with and kick off Moondust so that we can protect future surface spacecraft and habitats.
Astrobotic's first CLPS mission
In 2023, Astrobotic's lander will also touchdown in a lunar lava plain, Lacus Mortis, carrying 28 payloads from eight countries. These include 11 NASA instruments, chief of which are three spectrometers to track the movements of water on the Moon's surface. The mass spectrometer will also measure water and other volatiles released by the solar wind impinging the lunar soil. Such data will help scientists understand how water gets transported around the Moon, particularly from the equator to permanently shadowed regions on the poles, where it can remain preserved for billions of years.
Intuitive Machines' second CLPS mission
On its second Moon mission in 2023, Intuitive Machines will deliver NASA's PRIME-1 drill and a mass spectrometer to the Moon's south pole. The lander will drill up to 1 meter below the surface and analyze the soil for water ice, a first such study. The lander will also deploy a rover on the surface to test Nokia's 4G/LTE network on the Moon, another first. Further, there's the company's own NASA-supported hopper onboard called Micro-Nova, which will jump around the Moon with a camera to take high-resolution images of the surface under its flight path.
Intuitive Machines' lander on the Moon Illustration of Intuitive Machines' lander on the Moon with NASA's PRIME-1 drill attached.Image: Intuitive Machines
Masten's first CLPS mission
Masten Space's lander will touchdown on the Moon's south pole in November 2023. It will have at least eight instruments onboard, chiefly to detect water ice and other volatiles such as methane and carbon dioxide to help us understand the Moon's resource potential. The lander will also deploy Astrobotic's shoebox-sized autonomous rover called MoonRanger. NASA is making use of its capabilities by putting a neutron spectrometer onboard to detect signs of water ice below the surface.
VIPER rover delivery by Astrobotic
Astrobotic will deliver NASA's VIPER rover on the Moon's south pole in November 2024. The rover will explore areas in and around permanently shadowed regions for over 100 days, and use its drill and three instruments to unravel the nature of the Moon's water ice deposits, assess their resource potential, and determine how accessible they are. This will help us plan future human missions to the Moon's poles and eventually build sustainable habitats.
Firefly's first CLPS mission
Firefly's first Moon lander will descend in the lava plains of Mare Crisium in 2024, carrying several NASA instruments to study the lunar environment. One of the lander's legs will feature PlanetVac, a low-cost soil sampling technology partially funded by The Planetary Society to enable future sample return missions from the Moon, Mars and other planetary bodies. This mission will also be NASA's first attempt to get a GPS lock from the Moon.
VIPER rover and Griffin lander An artist's impression showing NASA's VIPER rover moving down a ramp of Astrobotic's Griffin lander.Image: Astrobotic
Intuitive Machines' third CLPS mission
Intuitive Machines' third Moon landing will be in the swirl of Reiner Gamma in 2024. Reiner Gamma has a weak local magnetic field, possibly a remnant from the time the Moon had a global magnetic field. The mission's primary payload suite Lunar Vertex is a collection of spectrometers and magnetometers on the lander and a rover to study the swirl's composition, and map the strength and direction of magnetic fields on the surface. This will help us better understand the effects of solar wind and bombarding micrometeorites on planetary bodies across the solar system, and shape our understanding of the Moon's magnetic evolution. The lander will also deploy four small CADRE rovers from NASA, which will autonomously navigate the landed region and collectively better map it than a single rover can.
Draper's farside CLPS mission
For its first CLPS mission in 2025, Draper will land a spacecraft on the Moon's farside, a feat only achieved by China's Chang'e 4 mission so far. The landing region chosen by NASA for the mission is no less impressive — the 312 kilometers wide Schrödinger crater, the most pristine impact feature of its kind. The lander will carry 95 kilograms of NASA's scientific instruments, which includes two highly sensitive seismometers, a drill, a probe, and a magnetic sounder, all to help us better understand the Moon's internal structure and composition, and how our cosmic neighbor evolved.
Expanding scope
With the mission selection to Reiner Gamma and Schrödinger, NASA began an enhanced science phase of its CLPS program. The next mission in this phase will visit the volcanic domes of Gruithuisen in 2026, and another south polar mission around the same time. NASA says future CLPS missions could also deliver more advanced rovers and technology demonstrations, and even infrastructure required by Artemis human landing missions.
A new commercial model for planetary missions
Landing on the Moon is hard. Only three countries have accomplished this feat so far — the U.S., the Soviet Union and China. The fact that NASA is entrusting commercial companies with the agency's crucial lunar scientific and technological objectives, many of which will directly affect their Artemis plans, shows their growing confidence in building a commercial ecosystem around lunar exploration.
CLPS also inverts the tradition of having only custom-built planetary missions to meet specific scientific goals. If enough of the CLPS missions stick the landing, it would open up frequent and periodic access to the Moon's surface for diverse scientific investigations in ways never possible before for any planetary body.
Artemis, NASA's Moon Landing Program
VIPER, NASA's Moon resource mapper
The Moon, preserving Earth's origin story
Support missions like CLPS
Whether it's advocating, teaching, inspiring, or learning, you can do something for space, right now. Let's get to work.
Acknowledgments: This page is authored and maintained by Jatan Mehta.
You are here: Home > NASA CLPS Moon landing missions


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Live UpdateFrom the Liveblog of Wednesday, January 25, 2023
Police publish video of Palestinian shot while carrying fake gun during clashes
By Emanuel Fabian 25 January 2023, 3:20 pm Edit
Emanuel (Mannie) Fabian is The Times of Israel's military correspondent.
: A suspect is seen carrying what appears to be a gun, during a police operation in the Shuafat refugee camp, January 25, 2023. (Israel Police)
Police publish footage of the Palestinian thought to have been armed who was shot in the Shuafat refugee camp.
The video shows the suspect pointing what appears to be a gun at the forces, then running away as officers open fire.
At one point he throws the item away, before collapsing.
The "gun" later turns out to be fake and not a real firearm, a police spokesperson says.
Police publish a video of the Palestinian who was shot in the Shuafat refugee camp, while it appeared he was armed with a gun. The weapon later turned out to be fake. pic.twitter.com/hrHrCEX2lr
— Emanuel (Mannie) Fabian (@manniefabian) January 25, 2023
The suspect is listed in critical condition after being shot.


+ * configure.ac: Fix goofs in my recent ImageMagick change.
+ * configure.ac, src/image.c: Tweak previous ImageMagick change.
+- ## might work - let us know if you find one.
+- ## 6.0.7 does not work. See bug#7955.
++ ## 6.3.5 is the earliest version known to work; see Bug#17339.
++ ## 6.8.2 makes Emacs crash; see Bug#13867.
+ /* The GIF library also defines DrawRectangle, but its never used in Emacs.
+ /* ImageMagick 6.5.3 through 6.6.5 hid PixelGetMagickColor for some reason.


text:
Trusted evidence.
Informed decisions.
Better health.
Beta-blockers versus placebo or no intervention for patients with suspected or diagnosed myocardial infarction
According to the World Health Organization, 7.4 million people died from ischaemic heart disease in 2012, representing 15% of all global deaths. The role of acute or subacute treatment with beta-blockers in people suspected of or diagnosed with a heart attack, rests on their inhibition of so-called beta-receptors. This may result in a reduction in the oxygen demand of the heart. Hence, the inhibition of the beta-receptor may or may not decrease the complications associated with heart attack.
Review question
The aim of this Cochrane Systematic Review was to assess the benefits and harms of beta-blockers in people with suspected or diagnosed acute myocardial infarction (heart attack).
We searched scientific databases from their inception to June 2019.
Study characteristics
We found 63 randomised clinical trials where people with or suspected of a heart attack were randomly allocated to receiving beta-blockers compared with placebo or no intervention. The 63 trials included 85,550 adults with a mean age of 57.4 years. Only one trial was at low risk of bias. The remaining trials were at high risk of bias. The quality of the evidence according to GRADE ranged from very low to high. Fifty-six trials commenced beta-blockers versus control during the acute phase of acute myocardial infarction and seven trials during the subacute phase.
Study funding sources
We found 33 trials that were fully or partly funded by the industry, 20 trials that did not report their funding source, and 10 trials that were funded by other sources than the industry.
Key results and conclusion
Our present review shows that people receiving beta-blockers compared with people receiving placebo or no intervention seem at lower risk of a new heart attack in the acute phase after a heart attack. People receiving beta-blockers also seem at lower risk of dying from any cause and from any cardiac cause at long-term follow-up after a heart attack. Nevertheless, people receiving beta-blockers do not seem to have a lower or a higher risk of dying from any cause or from any cardiac cause in the acute phase after a heart attack. The effects of beta-blockers on all remaining outcomes (serious adverse events according to International Conference on Harmonization - Good Clinical Practice, major adverse cardiovascular events (composite of dying from a cardiac cause and a new non-fatal heart attack), new heart attack at long-term follow-up, quality of life, and angina) are uncertain due to none or sparse data.
Authors' conclusions:
Our present review indicates that beta-blockers for suspected or diagnosed acute myocardial infarction probably reduce the short-term risk of a reinfarction and the long-term risk of all-cause mortality and cardiovascular mortality. Nevertheless, it is most likely that beta-blockers have little or no effect on the short-term risk of all-cause mortality and cardiovascular mortality. Regarding all remaining outcomes (serious adverse events according to ICH-GCP, major adverse cardiovascular events (composite of cardiovascular mortality and non-fatal myocardial infarction during follow-up), the long-term risk of a reinfarction during follow-up, quality of life, and angina), further information is needed to confirm or reject the clinical effects of beta-blockers on these outcomes for people with or suspected of acute myocardial infarction.
Read the full abstract...
Cardiovascular disease is the number one cause of death globally. According to the World Health Organization, 7.4 million people died from ischaemic heart diseases in 2012, constituting 15% of all deaths. Acute myocardial infarction is caused by blockage of the blood supplied to the heart muscle. Beta-blockers are often used in patients with acute myocardial infarction. Previous meta-analyses on the topic have shown conflicting results ranging from harms, neutral effects, to benefits. No previous systematic review using Cochrane methodology has assessed the effects of beta-blockers for acute myocardial infarction.
To assess the benefits and harms of beta-blockers compared with placebo or no intervention in people with suspected or diagnosed acute myocardial infarction.
Search strategy:
We searched CENTRAL, MEDLINE, Embase, LILACS, Science Citation Index Expanded and BIOSIS Citation Index in June 2019. We also searched the WHO International Clinical Trials Registry Platform, ClinicalTrials.gov, Turning Research into Practice, Google Scholar, SciSearch, and the reference lists of included trials and previous reviews in August 2019.
We included all randomised clinical trials assessing the effects of beta-blockers versus placebo or no intervention in people with suspected or diagnosed acute myocardial infarction. Trials were included irrespective of trial design, setting, blinding, publication status, publication year, language, and reporting of our outcomes.
Data collection and analysis:
We followed the Cochrane methodological recommendations. Four review authors independently extracted data. Our primary outcomes were all-cause mortality, serious adverse events according to the International Conference on Harmonization - Good Clinical Practice (ICH-GCP), and major adverse cardiovascular events (composite of cardiovascular mortality and non-fatal myocardial infarction during follow-up). Our secondary outcomes were quality of life, angina, cardiovascular mortality, and myocardial infarction during follow-up. Our primary time point of interest was less than three months after randomisation. We also assessed the outcomes at maximum follow-up beyond three months. Due to risk of multiplicity, we calculated a 97.5% confidence interval (CI) for the primary outcomes and a 98% CI for the secondary outcomes. We assessed the risks of systematic errors through seven bias domains in accordance to the instructions given in the Cochrane Handbook. The quality of the body of evidence was assessed by GRADE.
Main results:
We included 63 trials randomising a total of 85,550 participants (mean age 57.4 years). Only one trial was at low risk of bias. The remaining trials were at high risk of bias. The quality of the evidence according to GRADE ranged from very low to high. Fifty-six trials commenced beta-blockers during the acute phase of acute myocardial infarction and seven trials during the subacute phase.
At our primary time point 'less than three months follow-up', meta-analysis showed that beta-blockers versus placebo or no intervention probably reduce the risk of a reinfarction during follow-up (risk ratio (RR) 0.82, 98% confidence interval (CI) 0.73 to 0.91; 67,562 participants; 18 trials; moderate-quality evidence) with an absolute risk reduction of 0.5% and a number needed to treat for an additional beneficial outcome (NNTB) of 196 participants. However, we found little or no effect of beta-blockers when assessing all-cause mortality (RR 0.94, 97.5% CI 0.90 to 1.00; 80,452 participants; 46 trials/47 comparisons; high-quality evidence) with an absolute risk reduction of 0.4% and cardiovascular mortality (RR 0.99, 95% CI 0.91 to 1.08; 45,852 participants; 1 trial; moderate-quality evidence) with an absolute risk reduction of 0.4%. Regarding angina, it is uncertain whether beta-blockers have a beneficial or harmful effect (RR 0.70, 98% CI 0.25 to 1.84; 98 participants; 3 trials; very low-quality evidence) with an absolute risk reduction of 7.1%. None of the trials specifically assessed nor reported serious adverse events according to ICH-GCP. Only two trials specifically assessed major adverse cardiovascular events, however, no major adverse cardiovascular events occurred in either trial.
At maximum follow-up beyond three months, meta-analyses showed that beta-blockers versus placebo or no intervention probably reduce the risk of all-cause mortality (RR 0.93, 97.5% CI 0.86 to 0.99; 25,210 participants; 21 trials/22 comparisons; moderate-quality evidence) with an absolute risk reduction of 1.1% and a NNTB of 91 participants, and cardiovascular mortality (RR 0.90, 98% CI 0.83 to 0.98; 22,457 participants; 14 trials/15 comparisons; moderate-quality evidence) with an absolute risk reduction of 1.2% and a NNTB of 83 participants. However, it is uncertain whether beta-blockers have a beneficial or harmful effect when assessing major adverse cardiovascular events (RR 0.81, 97.5% CI 0.40 to 1.66; 475 participants; 4 trials; very low-quality evidence) with an absolute risk reduction of 1.7%; reinfarction (RR 0.89, 98% CI 0.75 to 1.08; 6825 participants; 14 trials; low-quality evidence) with an absolute risk reduction of 0.9%; and angina (RR 0.64, 98% CI 0.18 to 2.0; 844 participants; 2 trials; very low-quality evidence). None of the trials specifically assessed nor reported serious adverse events according to ICH-GCP.
None of the trials assessed quality of life.
We identified two ongoing randomised clinical trials investigating the effect of early administration of beta-blockers after percutaneous coronary intervention or thrombolysis to patients with an acute myocardial infarction and one ongoing trial investigating the effect of long-term beta-blocker therapy.
Beta-blockers for myocardial infarction
Heparins reduce the number of heart attacks but caused more minor bleeding after non-ST elevation acute coronary syndromes compared with placebo
Statins for acute coronary syndrome
Intravenous magnesium for acute myocardial infarction
Low molecular weight heparins reduce the number of heart attacks and cause fewer complications after an acute coronary syndrome compared to unfractionated heparin
Heart & circulation > Myocardial ischemia/coronary disease > Acute coronary syndrome
Safi S, Sethi NJ, Nielsen E, Feinberg J, Gluud C, Jakobsen JC
Primary Review Group:
Heart Group
See the full Review on
the Cochrane Library
Safi S, Sethi NJ, Nielsen E, Feinberg J, Jakobsen JC, Gluud C. Beta-blockers for suspected or diagnosed acute myocardial infarction. Cochrane Database of Systematic Reviews 2019, Issue 12. Art. No.: CD012484. DOI: 10.1002/14651858.CD012484.pub2
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Soyabean glycinin depresses intestinal growth and function in juvenile Jian carp (Cyprinus carpio var Jian): protective effects of glutamine.
However, dietary glycinin exposure decreased both the activity and mRNA levels of nine isoforms of glutathione-S-transferase (GST) (α, μ, π, ρ, θ, κ, mGST1, mGST2 and mGST3), indicating toxicity to this enzyme activity and corresponding isoform gene expressions.
Targeted imputation of sequence variants and gene expression profiling identifies twelve candidate genes associated with lactation volume, composition and calving interval in dairy cattle.
There was statistical support for imputed sequence variants in or close to BTRC, MGST1, SLC37A1, STAT5A, STAT5B, PAEP, VDR, CSF2RB, MUC1, NCF4, and GHDC associated with milk production, and EPGN for calving interval.
In contrast to LTC4S, MGST2 displays a 1/3 the sites reactivity, a mechanism shared with the more distant family member MGST1 and recently suggested also for microsomal prostaglandin E synthase-1.
Expression profile of eight glutathione S-transferase genes in Crassostrea ariakensis after exposure to DSP toxins producing dinoflagellate Prorocentrum lima.
In this study, changes in eight GSTs mRNA level including GST-α, GST-σ, GST-ω, GST-π, GST-μ, GST-ρ, GST-θ and microsomal GST (mGST) in the oyster Crassostrea ariakensis after exposure to Prorocentrum lima have been evaluated by quantitative real-time PCR.
Orai3 Surface Accumulation and Calcium Entry Evoked by Vascular Endothelial Growth Factor.
The signaling pathway coupling VEGF to the effect on Orai3 involved activation of phospholipase Cγ1, Ca(2+) release, cytosolic group IV phospholipase A2α, arachidonic acid production, and, in part, microsomal glutathione S-transferase 2, an enzyme which catalyses the formation of leukotriene C4 from arachidonic acid.
Rhodnius prolixus supergene families of enzymes potentially associated with insecticide resistance.
One microsomal GST gene was found and the cytosolic GST gene count (14 genes) is extremely low when compared to the other hemipteran species with sequenced genomes.
Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants.
near the MGST1 gene showed a genome-wide significant interaction with aspirin and/or NSAID use (P = 4.6 × 10(-9) for interaction).
In addition, 1785 SNPs in six genes (HEPH, MGST1, SERPINA, SLC25A45, SLC39A11 and UGT1A) were imputed from the 1000 Genomes Project and examined for association with INV EOC in white-European subjects.
The trabecular meshwork in normal eyes and in exfoliation glaucoma.
Genes differentially expressed in diseased ocular tissue or in cultured HTM cell models, and thus implicated in the disease process, include SOD2, ALDH1A1, MGST1, LOX, and LOXL1, elements of the transforming growth factor-β/bone morphogenetic protein/SMAD signaling pathways, connective tissue growth factor, matrix metalloproteinase-2, a tissue inhibitor of metalloproteinases also known as TIMP-2, and endothelin-1 (ET-1).
Characterization of new potential anticancer drugs designed to overcome glutathione transferase mediated resistance.
Two doxorubicin derivatives/prodrugs (DNS-DOX; MNS-DOX) are substrates for MGST1; neoplasm drug resistance can be overcome in cell lines over-expressing recombinant MGST1.
Role of MGST1 in reactive intermediate-induced injury.
Microsomal glutathione transferase 1: mechanism and functional roles.
Microsomal glutathione transferase 1 (MGST1) belongs to a superfamily named MAPEG (membrane-associated proteins in eicosanoid and glutathione metabolism).
Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents.
In this article we have reviewed the literature describing the mechanisms by which cytosolic and microsomal GST are up-regulated by xenobiotics, drugs, cytokines and endotoxin.
Mitochondrial glutathione transferases involving a new function for membrane permeability transition pore regulation.
In mitochondria, soluble (kappa, alpha, mu, pi, zeta) and membrane-bound glutathione transferases (GSTs) (MGST1) are distributed.
Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1.
Multiple roles of microsomal glutathione transferase 1 in cellular protection: a mechanistic study.
Overcoming resistance to conventional drugs in Ewing sarcoma and identification of molecular predictors of outcome.
The expression of MGST1, the microsomal glutathione S-transferase (GST), was found to clearly predict EWS prognosis.
Contribution of liver mitochondrial membrane-bound glutathione transferase to mitochondrial permeability transition pores.
These results indicate that mitochondrial membrane glutathione transferase in the outer mitochondrial membrane is activated by gallic acid, which may contribute to mitochondrial permeability transition pore formation.
Novel function of glutathione transferase in rat liver mitochondrial membrane: role for cytochrome c release from mitochondria.
Results indicate that mtMGST1 is activated through mixed disulfide bond formation that contributes to cytochrome c release from mitochondria through the MPT pore.
This review describes the three mammalian glutathione transferase (GST) families, namely cytosolic, mitochondrial, and microsomal GST, the latter now designated MAPEG.


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Physicist Awarded Grant to Study Physical Cell Biology
Tuesday, June 16, 2015, By Rob Enslin
College of Arts and Sciencesresearch
A physicist in the College of Arts and Sciences has been awarded a major grant to study how the shape and motion of individual cells mold biological tissues into three-dimensional shapes.
M. Lisa Manning
M. Lisa Manning, associate professor of physics, is part of a trio of researchers who have received $168,750 from the Gordon and Betty Moore Foundation and the Research Corp. for Science Advancement (RCSA) to explore untested ideas in physical cell biology. Their project, "Immersive DNA Force Sensors and Predictive Mechanical Modeling for Tissue Morphogenesis," grew out of a research competition recently held at Biosphere 2 in Arizona.
Manning's team includes Justin Kinney, assistant professor of biophysics at Cold Spring Harbor Laboratory, and Margaret Gardel, assistant professor of physics at the University of Chicago.
"As we grow from a fertilized egg into a human being, our cells push and pull against one another, shaping our tissues, our organs and our bodies," says Manning, who studies the mechanical behavior of biological cells. "Unfortunately, we don't know much about these microscopic forces, both within and between cells, and how they enable large, multicellular structures, such as people, to develop."
To address this complex phenomenon, she and her team have proposed an innovative method for measuring and modeling such forces in tissues. They plan to insert small "nanoprobes" of DNA into developing tissues to record where and when these forces occur. The team will also build predictive 3D computational models that will be directly tested with data from the new force probes—a first in the field of physical cell biology.
"Currently, there are methods for measuring forces in tissues along two-dimensional surfaces, but our proposal promises to enable such measurements in three dimensions," says Manning, adding that principles of theoretical physics will inform much of the process. "It will provide a critical advance for understanding how three-dimensional structures, such as organs, are formed."
The idea for the project was conceived during a March conference at Biosphere 2. The conference was part of a two-year Scialog program titled "Molecules Come to Life." Scialog—a portmanteau word blending "science" and dialogue"–is a conference that fosters intensive discussions, team building and on-the-spot collaborations among early-career researchers.
Manning says she and her teammates worked intensely over several days to create an "original, blue-sky, high-risk" research proposal.
"We were one of five interdisciplinary teams awarded grants," she says, adding that the conference included other early-career physicists, biologists and chemists. "By bringing together theorists and experimentalists, we are building a community of researchers that seek answers to important biological questions, while increasing our understanding of the physical biology of cells."
Rob Enslin