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COVID-19: Multinational study investigates 3 new treatments
Written by Timothy Huzar on August 23, 2021 — Fact checked by Ferdinand Lali, Ph.D.
Healthcare workers leave a COVID-19 patient's room in the intensive care unit of Lake Charles Memorial Hospital on August 10, 2021, in Louisiana. Mario Tama/Getty Images
The World Health Organization (WHO) Solidarity trial provided information about four potential COVID-19 treatments at the beginning of the pandemic.
After determining that none were effective, the researchers paused the trial at the end of 2020.
The trial is now entering a new phase, with up to 50 countries expected to take part.
The WHO has announced that its Solidarity clinical trial, which assesses potential treatments for COVID-19, is ready to resume.
In the previous phase, scientists investigated four potential treatments but found that none were effective. In the new phase, the researchers will test another three drugs.
Drug therapies
Since the emergence and global spread of SARS-CoV-2, the virus that causes COVID-19, scientists have focused on developing effective vaccines to minimize transmission and reduce the severity of the disease.
However, they have also tested potential treatments. This is important because many people have not yet been vaccinated, particularly in low-income countries.
And even where vaccination rates are high, scientists believe that the Delta variant of COVID-19 has reduced the effectiveness of the vaccines to 49% — meaning that many who are fully vaccinated could still develop the disease, and people who cannot receive vaccines are unlikely to be protected by herd immunity.
As a consequence, having effective treatments for severe COVID-19 could save a significant number of lives.
Speaking with Medical News Today, Dr. Rebecca Dezube, a specialist in pulmonology and assistant professor of medicine at Johns Hopkins University School of Medicine, in Baltimore, said that a number of treatments have already shown promise.
"The treatment with the most evidence for a mortality benefit in COVID-19 continues to be steroids, specifically dexamethasone."
"Tocilizumab, an immune modulator directed toward the interleukin-6 receptor, was shown to have a mortality benefit in the RECOVERY trial and to decrease the time patients required organ support in critically ill patients in the REMAP-CAP trial."
"In July 2021, the [WHO] issued a recommendation for tocilizumab for patients who are severely or critically ill with COVID-19, especially when administered along with corticosteroids," said Dr. Dezube.
She went on to note that baricitinib, ruxolitinib, and fedratinib, which are Janus kinase inhibitors, and lenzilumab, which neutralizes a cytokine linked to COVID-19, also showed promise.
Targeting the immune system
The restarted Solidarity trial will look at three potential treatments: artesunate, imatinib, and infliximab. A panel of experts selected these drugs because they had shown positive results in observational studies.
All three are repurposed medications that may modulate the inflammatory response, which can cause significant damage in people with severe COVID-19.
Artemisinin is a readily available, inexpensive malaria drug. Imatinib is used in cancer treatment, and it may offer protection against damage caused by inflammation in the lungs. Infliximab is used in the treatment of autoimmune diseases, such as inflammatory bowel disease.
The scientists are now exploring drugs that target the immune system, after having focused on antiviral medications in the last round of the Solidarity trial.
Speaking with MNT, Dr. John-Arne Røttingen, the chair of the Solidarity trial executive group and ambassador for global health at the Norwegian Ministry of Foreign Affairs, said:
"In the first phase, we attempted to use antiviral treatments. Now there's a general consensus that that's too late in the disease process, when people are already hospitalized. So then it's really the pathogen-host interaction and the host's response to the pathogen that is the most important target for drugs."
"There are definitely many more drugs to […] consider. We decided on these based on the assessment of the therapeutics advisory group of the WHO, but of course, others are trying other drugs, as well."
Dr. Shanthi Kappagoda, a clinical associate professor of medicine and infectious diseases at Stanford University, explained to MNT why it was crucial to identify drugs that affected the immune response.
"Every step in the virus's life cycle — from attaching to our cells, to entering the cell, to reproducing new virus components and assembling them into a new infectious viral particle — is a potential drug target. But as the virus mutates, direct-acting antiviral drugs which target these steps may become less effective."
"So, while I think direct-acting antiviral agents are important, targeting how the virus triggers acute respiratory distress syndrome is very important. I think this is likely why the WHO chose imatinib."
An effective treatment?
Dr. Røttingen added that during drug trials, it often takes time to find an effective treatment, as with the negative findings of the initial Solidarity trial. However, he was nonetheless hopeful about the trial's new phase.
"I think [not initially finding new treatments] is rather common, unfortunately. That's why rigorous research and evaluations are important."
"We see [quite solid evidence] from patient groups who use [these drugs] as chronic medication for the disease, and they seem to have better outcomes than others, but of course that can be confounded, so it's really important to examine [them] in a large, randomized trial."
"Artesunate is a very available drug. [However,] we don't have solid clinical evidence but more lab indications and data. But given that it's a globally available drug that is cheap, it's definitely worth examining," Dr. Røttingen said.
He also pointed out that critical care practice has developed to better respond to COVID-19, reducing the risk of mortality.
"The quality of […] acute care and how you use your best general means to optimize treatment in an intensive care setting is often overlooked. And we saw big variations in mortality outcomes across countries and across settings — even though we fully understand them, I think there's definitely also differences in routine care and programs."
New variant risks?
For Dr. Røttingen, the next year is an important time to explore new COVID-19 treatments. This is because finding new treatments may become more difficult as the virus becomes endemic — which is more likely, now that the Delta variant of SARS-CoV-2 has made herd immunity less achievable.
"That's now the most likely scenario, that this will be an endemic disease […] that we will need to live with in the coming years. But [now is the best opportunity] of doing robust, large randomized trials. [If the virus becomes endemic,] it's more challenging because […] it will be harder to organize and structure those trials. It's really important to do our best now, in the coming year."
While new variants are a concern, he explained, they are unlikely to diminish the effectiveness of treatments that target the immune system, such as those currently under study in the Solidarity trial.
"Since most of the treatments, or at least those that seem to be effective in hospitalized patients, are based on modulating the immune response, I don't expect [that] the new variants will be different, when it comes to treatment outcomes."
– Dr. John-Arne Røttingen
"Where there will be impact is on the antiviral side, and in particular the monoclonal antibodies and the cocktail of antibodies that have been tested and are still being developed and optimized — particularly in high risk groups that can be diagnosed early and that can be given antibodies early."
"That's definitely a space where new antibodies need to be developed and adjusted to the circulating variant. But otherwise I would expect that treatment effects would be fairly similar."
Dr. Kappagoda agreed:
"We have already seen how mutations in different parts of the virus — for example the spike protein — have made some monoclonal antibodies less effective, for example bamlanivimab and etesevimab."
"Direct-acting antiviral medicines, which target enzymes or other proteins [that] the virus needs to reproduce or enter our cells are also likely to be impacted by the mutations in SARS-CoV2 variants."
"This is less likely to be an issue in medicines that target our immune or inflammatory response, like dexamethasone or tocilizumab, since they do not directly work on the virus itself but on our immune response to it," she explained.
Dr. Dezube also highlighted the risk that new variants pose to monoclonal antibody treatments:
"Multiple SARS-CoV-2 variants of concern have reduced susceptibility to certain monoclonal antibody products. This is worrisome, as monoclonal antibodies are the only treatment, for patients not in the hospital, with a proven benefit. Fortunately, casirivimab/imdevimab appears to be effective against our current known variants."
Lessons to learn
Dr. Røttingen said that after the original Solidarity trial was paused, following negative results, it took longer than they had hoped to restart the trial.
"We had a too-long period […] before we could start again. That was first related to the need to scan the opportunities and the most viable potential [treatments]; then it was the agreeing on drugs to ensure we had a sufficient supply that could be distributed to countries in all regions, including [agreeing] with the potential manufacturers that they would be committed to sound access possibilities and availability of the drugs, in particular in low-income countries, if they proved to be successful."
Dr. Røttingen told MNT more about how ethical and regulatory approvals were delayed, compared with the speedy approvals at the start of the pandemic.
"We managed to set up the first phase of Solidarity very quickly, a month or maybe a month and a half from protocols ready until we recruited the first patient. I think at that time, there was an understanding [from] all regulatory authorities that this is a crisis, and we need to go outside normal timelines. I think that understanding is now less pressing, and probably [regulatory authorities] are pushed on other fronts.
"We need to have more speedy processes. When there is an epidemic, when there is an outbreak, we need to test drugs — where the risk and the disease is time-dependent and the opportunity to do the trial is really critical and time-dependent."
"That needs to be done in individual countries, but in addition, I think we should look for harmonized and coordinated approval processes, so that instead of needing to go and have approval in all individual countries, there would at least be some preapproval at an international level that could then be adopted by countries, in maybe a more expeditious and faster process."
"We don't have that system today, and that's something that needs to be looked into."
For Dr. Røttingen, it is important that new structures are put in place to ensure that approval can be granted safely but quickly. The initial goodwill from regulatory agencies, pharmaceutical companies, and the scientific community is not sustainable.
"We see that [the goodwill is] really still there, but I think now […] the system is a bit exhausted and has a need to go back to normal operations. And those are too slow."
Dr. Kappagoda also highlighted lessons to be learned from the initial response to the pandemic.
"I think one silver lining of the pandemic is that ministries of health, hospitals, and universities have recognized the importance of making clinical research more nimble and efficient during an emergency."
"Small changes, like having institutional review boards meet remotely, strengthening fast-tracking and prioritization systems for clinical research, and having systems in place to do informed consent via video chat should remain in place, ready for future pandemics."
"Participating in trials such as Solidarity […] can build capacity for future clinical research at hospitals and medical centers which previously may not have been heavily involved in research," she added.
"Clinical researchers newly involved in multicenter trials during this pandemic will be developing professional networks, which can help them navigate the clinical research process for future pandemics."
Pharma Industry / Biotech Industry
Are COVID-19 vaccine boosters the way forward?
In this Special Feature, we examine the issue of COVID-19 vaccine boosters, including why they might be necessary and who might need them most…
COVID-19 vaccine: If you had no side effects, are you protected?
In this Snapshot feature, we answer a commonly asked question: If you have not had side effects after a COVID-19 vaccine, are you protected against…
COVID-19 in Southeast Asia: Current situation and outlook
In this Special Feature, we examine how the COVID-19 pandemic is evolving in Southeast Asia, and two experts propose solutions going forward.
How do COVID-19 vaccines work?
Vaccines train our immune system to fight future infections. In this feature, we highlight the different types of COVID-19 vaccines and explain how…
Coronavirus (COVID-19) vaccine: What to know
COVID-19 vaccines are now becoming available. Here, learn how each type works, how to get a vaccine, and how to prevent infection in the meantime.


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redpajama_set_name: RedPajamaGithub


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Home»News»Women on patrol for safe Valentine's Day
Women on patrol for safe Valentine's Day
By Stephen Taylor February 1, 2016 Updated: February 8, 2016 No Comments2 Mins Read
Girl power: An all-female patrol will ensure safety in the water at Gunnamatta on 14 February. They include Fran Brown, Dani Silvester, Emma Brown, Lucy Douglas and Jill Douglas, with the assistance of regional officer Toby Dobell. Picture: Yanni
AN all-female patrol on Valentine's Day, Sunday 14 February will – for the first time – protect swimmers at Gunnamatta surf beach.
The "Pink Patrol" – part of the celebrations for the lifesaving club's 50th year – recognises women and their contribution to lifesaving.
Patrol captain Jill Douglas will lead the team on the day. She's proud to be part of a "first" in the club's history.
"I'm really looking forward to Valentine's Day," the chief instructor said. "We have some very experienced and dedicated girls who can't wait to team up and show a bit of 'girl power'.
"It is a day of love and we are all out here doing what we love: the beach, the surf and keeping them safe.
"Gunn [Gunnamatta] has a proud history in surf lifesaving: our club has won the state patrol efficiency award more than any other club, and we perform about a third of Victoria's rescues each year.
"All beaches and waterways have their dangers. Gunn has its own but we make sure we set patrols up in the safest possible area and we monitor it carefully.
"It's an honour to lead this patrol in our 50th birthday year."
Gunnamatta SLSC Club captain Patrick Murphy said the capability of the Pink Patrol were impressive. "Collectively its members hold all of SLSA's awards and qualifications as well as being powerful surf swimmers and rescue board paddlers," he said.
Women and girls were permitted to join Surf Life Saving Australia as active members in 1980. Gunnamatta had two female lifesavers from the very first days and this quickly grew over the following summers.
Now, 40 of Gunnamatta's 100 active members are female, ranging in age from 13 to over 50. They hold positions such as chief instructor, patrol captain and rescue boat drivers – some of the most senior roles in the club.
Mr Murphy said the female patrol's message was: "If we can see you, we can save you."
First published in the Southern Peninsula News – 2 February 2016
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redpajama_set_name: RedPajamaCommonCrawl


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Disentangled Multidimensional Metric Learning for Music Similarity
Music similarity search is useful for a variety of creative tasks such as replacing one music recording with another recording with a similar "feel", a common task in video editing. For this task, it is typically necessary to define a similarity metric to compare one recording to another. Music similarity, however, is hard to define and depends on multiple simultaneous notions of similarity (i.e. genre, mood, instrument, tempo). While prior work ignore this issue, we embrace this idea and introduce the concept of multidimensional similarity and unify both global and specialized similarity metrics into a single, semantically disentangled multidimensional similarity metric. To do so, we adapt a variant of deep metric learning called conditional similarity networks to the audio domain and extend it using track-based information to control the specificity of our model. We evaluate our method and show that our single, multidimensional model outperforms both specialized similarity spaces and alternative baselines. We also run a user-study and show that our approach is favored by human annotators as well.
J. Lee, N.J. Bryan, J. Salamon, Z. Jin, J. Nam
In IEEE International Conference on Acoustics, Speech, and Signal Processing (ICASSP), Barcelona, Spain, May 2020.
[IEEE][PDF][BibTeX][Copyright]
Birdvox-full-night: A Dataset and Benchmark For Avian Flight Call Detection
We've just released Birdvox-full-night, a new challenging dataset for machine learning on bioacoustic data! Details about the dataset and the models we benchmarked are provided in our ICASSP 2018 paper:
V. Lostanlen, J. Salamon, A. Farnsworth, S. Kelling, and J. P. Bello
In IEEE International Conference on Acoustics, Speech, and Signal Processing (ICASSP), Calgary, Canada, Apr. 2018.
[PDF][Copyright]
This article addresses the automatic detection of vocal, nocturnally migrating birds from a network of acoustic sensors. Thus far, owing to the lack of annotated continuous recordings, existing methods had been benchmarked in a binary classification setting (presence vs. absence). Instead, with the aim of comparing them in event detection, we release BirdVox-full-night, a dataset of 62 hours of audio comprising 35402 flight calls of nocturnally migrating birds, as recorded from 6 sensors. We find a large performance gap between energy based detection functions and data-driven machine listening. The best model is a deep convolutional neural network trained with data augmentation. We correlate recall with the density of flight calls over time and frequency and identify the main causes of false alarm.
You can download the dataset here: https://wp.nyu.edu/birdvox/birdvox-full-night/
You can also check out additional bioacoustic datasets for machine learning we have released as part of the BirdVox project here: https://wp.nyu.edu/birdvox/codedata/#datasets
Finally, if you're at ICASSP 2018 and want to learn more be sure to grab my esteemed colleague Vincent Lostanlen for a chat!
New Book Chapter: Sound Analysis in Smart Cities
This chapter introduces the concept of smart cities and discusses the importance of sound as a source of information about urban life. It describes a wide range of applications for the computational analysis of urban sounds and focuses on two high-impact areas, audio surveillance, and noise pollution monitoring, which sit at the intersection of dense sensor networks and machine listening. For sensor networks we focus on the pros and cons of mobile versus static sensing strategies, and the description of a low-cost solution to acoustic sensing that supports distributed machine listening. For sound event detection and classification we focus on the challenges presented by this task, solutions including feature design and learning strategies, and how a combination of convolutional networks and data augmentation result in the current state of the art. We close with a discussion about the potential and challenges of mobile sensing, the limitations imposed by the data currently available for research, and a few areas for future exploration.
Sound analysis in smart cities
J. P. Bello, C. Mydlarz, and J. Salamon.
In T. Virtanen, M. D. Plumbley, and D. P. W. Ellis, editors, Computational Analysis of Sound Scenes and Events, pages 373–397. Springer International Publishing, 2018.
[Springer][PDF][BibTeX]
Bettering the World Through Entrepreneurship: Urban Issues
The NYU Entrepreneurial Institute has written an article about how technology & entrepreneurship can help solve urban problems, with a focus on our SONYC project. Read the full article here.
Can the Internet of Things & AI Solve Urban Noise?
New York City is a loud place. In fact, 9 of 10 adults in NYC are exposed to harmful levels of noise, which can lead to sleep loss, hearing loss and even heart disease. Can anything be done about it? The SONYC research project combines internet of things sensing technology, machine learning, data science and citizen science to tackle noise pollution head on at city scale. Come hear about a sensor that can recognize sounds like a human and how we plan to use it to improve quality of life in NYC.
The talk will be followed by my colleague and astrophysicist Federica Bianco with her talk:
Twinkle twinkle little city-light!
When: Wednesday, April 26, 2017, 7:30pm 10:00pm
Where: SingleCut Beersmiths, 19-33 37th Street NY, 11105 United States (map)
Registration: https://tasteofscience.org/ny-events/thescientificcity
Deep Convolutional Neural Networks and Data Augmentation For Environmental Sound Classification
The ability of deep convolutional neural networks (CNN) to learn discriminative spectro-temporal patterns makes them well suited to environmental sound classification. However, the relative scarcity of labeled data has impeded the exploitation of this family of high-capacity models. This study has two primary contributions: first, we propose a deep convolutional neural network architecture for environmental sound classification. Second, we propose the use of audio data augmentation for overcoming the problem of data scarcity and explore the influence of different augmentations on the performance of the proposed CNN architecture. Combined with data augmentation, the proposed model produces state-of-the-art results for environmental sound classification. We show that the improved performance stems from the combination of a deep, high-capacity model and an augmented training set: this combination outperforms both the proposed CNN without augmentation and a "shallow" dictionary learning model with augmentation. Finally, we examine the influence of each augmentation on the model's classification accuracy for each class, and observe that the accuracy for each class is influenced differently by each augmentation, suggesting that the performance of the model could be improved further by applying class-conditional data augmentation.
For further details see our paper:
J. Salamon and J. P. Bello
IEEE Signal Processing Letters, In Press, 2017.
Fusing Shallow and Deep Learning for Bioacoustic Bird Species Classification
Automated classification of organisms to species based on their vocalizations would contribute tremendously to abilities to monitor biodiversity, with a wide range of applications in the field of ecology. In particular, automated classification of migrating birds' flight calls could yield new biological insights and conservation applications for birds that vocalize during migration. In this paper we explore state-of-the-art classification techniques for large-vocabulary bird species classification from flight calls. In particular, we contrast a "shallow learning" approach based on unsupervised dictionary learning with a deep convolutional neural network combined with data augmentation. We show that the two models perform comparably on a dataset of 5428 flight calls spanning 43 different species, with both significantly outperforming an MFCC baseline. Finally, we show that by combining the models using a simple late-fusion approach we can further improve the results, obtaining a state-of-the-art classification accuracy of 0.96.
J. Salamon, J. P. Bello, A. Farnsworth and S. Kelling
In IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), New Orleans, USA, March 2017.
Three New Datasets For Bioacoustic Machine Learning
We're happy to announce the release of 3 new datasets for research on automatic bioacoustic bird species recognition. The datasets were compiled for our recently published study "Towards the Automatic Classification of Avian Flight Calls for Bioacoustic Monitoring", and are freely available on the Dryad Digital Repository:
CLO-43SD: 5,428 labeled audio clips of flight calls from 43 different species of North American woodwarblers (in the family Parulidae). The clips came from a variety of recording conditions, including clean recordings obtained using highly-directional shotgun microphones, recordings obtained from noisier field recordings using omnidirectional microphones, and recordings obtained from birds in captivity.
Rosetta Stone For Warblers' Migration Calls. Source: https://www.allaboutbirds.org/a-rosetta-stone-for-identifying-warblers-migration-calls/
CLO-WTSP: 16,703 labeled audio clips captured by remote acoustic sensors deployed in Ithaca, NY and NYC over the fall 2014 and spring 2015 migration seasons. Each clip is labeled to indicate whether it contains a flight call from the target species White-Throated Sparrow (WTSP), a flight call from a non-target species, or no flight call at all.
CLO-SWTH: 179,111 labeled audio clips captured by remote acoustic sensors deployed in Ithaca, NY and NYC over the fall 2014 and spring 2015 migration seasons. Each clip is labeled to indicate whether it contains a flight call from the target species Swainson's Thrush (SWTH), a flight call from a non-target species, or no flight call at all.
CLO-43SD is targeted at the closed-set N-class problem (identify which of of these 43 known species produced the flight call in this clip), while CLO-WTSP and CLO-SWTH are targeted at the binary open-set problem (given a clip determine whether it contains a flight call from the target species or not). The latter two come pre-sorted into two subsets: Fall 2014 and Spring 2015. In our study we used the fall subset for training and the spring subset for testing, simulating adversarial yet realistic conditions that require a high level of model generalization.
For further details about the datasets see our article:
Towards the Automatic Classification of Avian Flight Calls for Bioacoustic Monitoring
J. Salamon , J. P. Bello, A. Farnsworth, M. Robbins, S. Keen, H. Klinck and S. Kelling
PLOS ONE 11(11): e0166866, 2016. doi: 10.1371/journal.pone.0166866.
[PLOS ONE][PDF][BibTeX]
You can download all 3 datasets from the Dryad Digital Repository at this link.
Towards the Automatic Classification of Avian Flight Calls for Bioacoustic Monitoring
A white-throated sparrow, one of the species targeted in the study. Image by Simon Pierre Barrette, license CC-BY-SA 3.0.
Automatic classification of animal vocalizations has great potential to enhance the monitoring of species movements and behaviors. This is particularly true for monitoring nocturnal bird migration, where automated classification of migrants' flight calls could yield new biological insights and conservation applications for birds that vocalize during migration. In this paper we investigate the automatic classification of bird species from flight calls, and in particular the relationship between two different problem formulations commonly found in the literature: classifying a short clip containing one of a fixed set of known species (N-class problem) and the continuous monitoring problem, the latter of which is relevant to migration monitoring. We implemented a state-of-the-art audio classification model based on unsupervised feature learning and evaluated it on three novel datasets, one for studying the N-class problem including over 5000 flight calls from 43 different species, and two realistic datasets for studying the monitoring scenario comprising hundreds of thousands of audio clips that were compiled by means of remote acoustic sensors deployed in the field during two migration seasons. We show that the model achieves high accuracy when classifying a clip to one of N known species, even for a large number of species. In contrast, the model does not perform as well in the continuous monitoring case. Through a detailed error analysis (that included full expert review of false positives and negatives) we show the model is confounded by varying background noise conditions and previously unseen vocalizations. We also show that the model needs to be parameterized and benchmarked differently for the continuous monitoring scenario. Finally, we show that despite the reduced performance, given the right conditions the model can still characterize the migration pattern of a specific species. The paper concludes with directions for future research.
The full article is available freely (open access) on PLOS ONE:
Along with this study, we have also published the three new datasets for bioacoustic machine learning that were compiled for this study.
SONYC featured in New York Times, NPR, Wired and more
Today SONYC was featured on several major news outlets including the New York Times, NPR and Wired! This follows NYU's press release about the official launch of the SONYC project.
Needless to say I'm thrilled about the coverage the project's launch is receiving. Hopefully it is a sign of the great things yet to come from this project, though, I should note, it has already resulted in several scientific publications.
Here's the complete list of media articles (that I could find) covering SONYC. The WNYC radio segment includes a few words from yours truly :)
To Create a Quieter City, They're Recording the Sounds of New York
BBC World Service - World Update (first minute, then from 36:21)
Mapping New York City's Excessively Loud Sounds
New York, come usare i microfoni per una città più silenziosa
Scientists Are Tracking New York Noisiness in Order to Quiet It Down
NYU Scientists are Trying to Reduce Noise Pollution in New York City
Researchers Are Recording New York to Make it Quieter
Sounds of New York City (German Public Radio)
NYC's $5 Million Noise Pollution Project
Mapping the Sounds of New York City Streets
New UrbanEars project has NYU teaming up with Ohio State to battle noise pollution
NYU Launches Research Initiative to Combat NYC Noise Pollution
Smart microphones are recording city sounds to help create a quieter New York
NYU Moves Forward with Study of City Noise
How to Take on NYC's Scary Noise Problem
Research Initiative Looks to Tame Urban Noise Pollution
If you're interested to learn more about the SONYC project have a look at the SONYC website. You can also check out the SONYC intro video:


How to get real value from your marketing automation - #LetsGrow!
A marketing automation platform is nothing more than a tool in the business development toolbox. It is a powerful tool, an essential tool, a time-saving, insight-gathering, results-generating tool, and so much more, yet only a tool. Like any tool, you have to know how to use it for the specific job at hand. When you consider that as much as 60% of users don't use their MAP properly, if at all, you have to look at the setup, training, and adoption to find out why such a powerful tool is wasted.
You can't just log in and expect the magic to happen. You have to know how to set it up, how to customize it for your work style, how to leverage all its sophisticated features, and how to get everyone on board. One reason why so many companies fail to see value in their platform is this very reason. They think it will be as easy as using Word. They think they can prospect just like they always have. They believe they will figure it out as they go. Sadly, too many get stymied, frustrated, and give up.
In my experience, which includes many failed attempts at adopting new technologies, it requires an intentional three-step approach. Like a musical instrument, first you have to learn the notes, then apply them to simple tunes, after which comes the confidence to make beautiful music. Unlike music, you've got to get your MAP working as quickly as possible to turn the investment into results. Such is the challenge between training and ROI. Is it 30, 60, 90-days, a year? How about a week?
I've been using SharpSpring for about 2 and a half years now exclusively for ad agency business development with many different agencies. In that time, I've learned how to make SharpSpring work best for ad agency prospecting. That's why I call it the ad agency prospecting platform. While it is true that each agency is different and there isn't a one-size-fits-all, knowing the right features to activate, the best automation, the essential lists, the correct email approach, the best reports to generate, all contribute to the most productive experience for agencies.
If you've used a MAP, CRM or EMP before you know that they are designed and configured for the most common use case or more aptly put, the lowest common denominator. Most are customizable to some extent to support your approach to marketing, but many have limitations, some are very limited with the intent to make it "easy." I've found that those limitations together with the lowest common denominator configuration result in frustration and uncertainty. You either have to call customer services, again or you stop trying. I can't tell you how many agencies I've seen using their costly platform for nothing more than a spreadsheet. Remember, Google Sheets are free.
No matter what system you use, you have to start with a plan. That plan begins with your prospect. You probably have a prospect list, or many different lists compiled over the years. To be more successful you need to distill those lists into groups of similar characteristics like industry or audiences and decide on the kind of information you want to know about each prospect to understand their potential and create personalized marketing campaigns that catch their attention and inform their perception of your agency. I know exactly how to configure my prospect records to inform my outreach properly. Too much information can slow your process while too little can minimize your results. Who is connected on LinkedIn? Who has any past relationship with the prospect or the company? Who as previous experience in the vertical? What has the contact been with the prospect over the years? Where were they before? All the questions you seek to know before reaching out sits on one simple page when you need it.
Your prospect embarks on a journey to identify, qualify, and verify agencies before they pick. Research tells us that prospects typically travel about 60% of their journey before you know they are checking you out. Today, agencies must connect and influence decisions during that 60% if they have any hope of making it on the list. Tracking visits to the website, automating responses, pushing out content, bringing lookers into the blog, showcasing the right positioning and value to the right prospects take so much mystery out of a mysterious process. Knowing how to set up the triggers and automation to guide unknown lookers along their journey can have a significant impact on all your funnel metrics.
The other statistic to keep in mind is that only a small percentage of your potential opportunity is looking for help today. No matter what kind of agency you are, the majority of prospects don't need your help until sometime in the near or far future. Unfortunately, it's human nature to forget about those future opportunities. Out of sight, out of mind. Setting up strategies and automating them for future opportunity ensures a flowing pipeline both short and long-term. It also captures potential future revenue to use in forecasting and planning. Correctly set up and configured, a MAP allows you to manage exponentially more prospecting, both for today and tomorrow.
Speaking of mysteries, what used to be a complete mystery, the early engagement behaviors of prospects is now a little bit clearer. With website, landing page, and content tracking, you can begin to connect the behavior dots of your prospect to understand better what they are interested in, what stage they are in their journey, and whether they are serious or just kicking tires. Setting up and defining your assets in the right way and then connecting them along the journey will provide a complete picture and better inform the next steps to take to keep the prospecting moving through the planned steps you set up in the beginning.
In my opinion these are the most valuable prospecting features of SharpSpring's marketing automation platform to guide your next client through their journey.
I have no doubt you can figure all this out yourself. Moreover, with the time, initiative and help from the right people in the agency, you will become a MAP aficionado. However, why reinvent the wheel when you and I can get the agency up and running in a week, more or less? Why not combine hard-earned experience with your ingenuity to short-circuit the learning curve, adoption, and ROI? Why not cheat your competition and jump to the head of the line? Why not give me a call, so I will tell you what we will do to get you your own ad agency prospecting platform.
I want to help you get your own Agency prospecting platform. Click on Schedule a Call and let's talk about your experience with marketing automation. If you like this post, click the thumbs up, so I'll know and then sign up for my new business newsletter. Follow me on Twitter and LinkedIn for daily tips, tricks, and insights. #LetsGrow!


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AMA Knoxville September Luncheon: Let People Into Your Story!
Bedard dives into an explanation of why you should strive for story telling with your brand. The first is the idea of "Noise v Music." Bedard compares "noise" to a confusing ad that your brain can't understand. American consumers are bombarded with noise. Your ads should be music that tells your customer your brand story.
Since "clarity is key," it is imperative that your ad be as clear as possible in order to capture and keep your audience's attention. Bedard uses Apple as a prime example of this form of clear storytelling. "Stories make so much sense" in the marketing world because American's are "starving for stories." People spend $500B a year at the movies. This is evidence that your brand should be capitalizing on this need for stories.
The structure of a story includes some fundamental components that can translate into your brand storytelling. The first of these key features is "the hero." Each of these heroes has a conflict or problem that they must overcome. In order to overcome this issue, they need a guide to give them a plan and call them to action. Bedard describes this structure using pop culture references, such as Luke Skywalker and Yoda in Star Wars.
In this structure, your customer must be the "hero." Your product and brand need to be the "guide" that gives them a plan to lead them to action and overcome their problem. For this structure to work, Bedard recommends to "boil it down to how a brain can understand it." He suggests that even something as simple as a big, red button on your website that says "BUY NOW" can be a solution to your customer's problem.
When applying this process to Bristol Motor Speedway, Bedard found his "heroes," or customers, to be blue-colored, Southern individuals looking for an amazing experience. Their problem is that they "lead stressful lives" and need an outlet to relax and "feel a sense of community." His team then presents their brand as a guide to help their customers overcome their problem. Bristol Motor Speedway is marketed as an exciting, custom experience to share with a like-minded community.
The best way to organize your company's brand is to come up with The Statement, or "The One Liner." According to Bedard, this is a critical step in the process to simplifying your brand's story. To come up with this "One Liner," you will need to identify "the problem, the solution and the reward." Bedard's team worked to come up with a one liner that applied to Bristol Motor Speedway.
Bedard challenged the audience to go back to their office that afternoon and come up with a statement like this that would apply to their brand. He stressed the necessity of making this statement as clear and concise as possible.


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James Bond 007: NightFire
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Generally favorable reviews - based on 20 Critic Reviews What's this?
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Summary: The ultimate secret agent is back in his most dangerous adventure yet in James Bond 007: NightFire. Explore new heights and depths like never before-infiltrate towering skyscrapers, take on treacherous underwater missions, and maneuver your sleek Aston Martin V12 Vanquish through the streetsThe ultimate secret agent is back in his most dangerous adventure yet in James Bond 007: NightFire. Explore new heights and depths like never before-infiltrate towering skyscrapers, take on treacherous underwater missions, and maneuver your sleek Aston Martin V12 Vanquish through the streets of Tokyo while turning on the Bond charm with glamorous (and sometimes deadly) Bond women. New state-of-the-art upgradeable gadgets and weapons and original missions including zero-gravity assignments will leave you shaken and stirred. [Electronic Arts]… Expand
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Developer: Eurocom Entertainment Software
Genre(s): Action, Shooter, First-Person, Modern
# of players: 1-4
Cheats: On GameFAQs
Rating: T
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ECTS 2002James Bond 007: NightFire Trailer 1
Score distribution:
Positive: 13 out of 20
Mixed: 7 out of 20
Negative: 0 out of 20
Official U.S. Playstation Magazine
It really does feel like an interactive Bond flick. [Jan 2003, p.130]
All this publication's reviews
It's fun as far as it goes, but the experience can't help but feel a little limited at times -- you go there, you do this, you whack a few bad guys in between, and do it all over again once a new objective arises.
Maxim Online
Stealing the best gadgets and characters from the movies, NightFire lets you decide how to topple the requisite megalomanical villain: Use stealth and gizmos (like Eurobabe-revealing x-ray specs—thanks, Q!) or go in guns blazing.
GamingWorld X
Yes, the game is quite short, there are some tremendous lapses in storytelling logic, and there is some mindless, put-your-fist-through-the-screen repetition that makes you long for the earlier, more innovative levels of the game. But the game is one of the best to capture the Bond experience since "Goldeneye."
Gaming Maxx
Multiplayer fans should skip this title and pick up "Timesplitters 2" or "Red Faction 2" instead.
GameCritics
A little more challenge, depth, and length with the trimming of the lame on-rails levels would have made this one a near classic. As it is, though, it's an above-average shooter with just enough variety and charm to make the familiar trip worth your time.
It's bad enough that you have to sit there and watch as Bond does his thing, but what's really frustrating is that these [cinematic] sequences (parachuting off a skyscraper, somersaulting to avoid gunfire) illustrate precisely the kind of actions that you should be able to control. [22 Nov 2002, p.84]
See all 20 Critic Reviews
RJblake
This game is great for peopl who like first person shooters.
0 of 0 users found this helpful
huwd6
Nightfire is the best Bond game since Goldeneye 007 on the N64. The story mode has a great plot and numerous difficulty settings, however itNightfire is the best Bond game since Goldeneye 007 on the N64. The story mode has a great plot and numerous difficulty settings, however it is a bit too short.
The multiplayer game is brilliant, the bots aren't brilliant but there are many characters to choose from and personalities along with game rules and weapon sets can be adjusted to a tee. While now in 2010 the graphics are slightly dated they do stand up somewhat. A fun game.… Expand
DoctorSpaceman
What a great game. The multiplayer to this day is tough to beat. Shooter games are one genre that I find grows less fun as it gets moreWhat a great game. The multiplayer to this day is tough to beat. Shooter games are one genre that I find grows less fun as it gets more realistic, and this one has just the right blend of realism and, in certain spots, a fun lack thereof.… Expand
RyanM.
One of my favorite first person shooters ever. I love this game, but only if i owned it...
hustlie
Suit up and get ready for action because you're about to experience the life of an agent in 007: Nightfire. The 21st in the series, releasedSuit up and get ready for action because you're about to experience the life of an agent in 007: Nightfire. The 21st in the series, released in 2002, as James Bond you will combine stealth, efficiency and class as you carefully plan out approaches, strategies and takeouts all while using your secret agent gadgets to progress through each level. Unique in it's first-person style, there is a myriad of weapons, machinery and gadgets to choose from, all with their corresponding uses to finishing each individual mission. Complete with explosions, helicopters, hot babes and the Aston Martin V12 Vanquish, this game is sure to take you on an immersive journey that is reminiscent of that classic cinematic style we've come to know and love in movies today.
The main quest can be easy to progress at times. There's very few levels that will leave you stumped trying to figure out the next objective but if you happen to get stuck somewhere, the game lends a hand by giving you a simple text hint in the menu options which can be useful at times, even when you aren't stuck on a mission. Now, What I'm about to say might just be a matter of opinion but I believe the speed of the character in the general sense, is a bit slow. While the movement is fluid in nature and you have vast freedom of control... the levels that this character was designed for almost seem out of place and could be aided with the help of added mobility or speed in some parts. Although, It's very satisfying to go through each level even after completion and I think this game has earned it's spot as one with a lot of replayability.
You might think because of it's first-person experience, there isn't much that can be done in terms of control... I whole-heartedly disagree. After a quick look at the menu options, this game makes it easy for anyone to become a pro. It comes packed with 8 different control schemes all designed to do the exact same thing in a more comfy, easy and most importantly, personalized manner that you might not find in other similar games which could be the difference maker in terms of enjoyment and whether you think that game is good or not. It even goes a step further and gives you customizable Y-Axis inversion options in cause you're naturally comfortable with what's known as "reverse controls". Once you've found your niche, it's easy to target, aim, shoot, scroll, shift, slide, strafe in whatever creative ways you can think of, so I would advise to make use of this as early as possible, as it's very important.
The ESRB rating on the box says T for Teen which makes it very accessible to just about anyone and the theme of the game just resonates well with typical consumable media that just about anyone can get behind. Again, this game... coming from a movie background, does a good job of blending in with the industry that also doesn't stray too far away from home. It's rare to see games like this fit so well and bring new elements to the table almost shaping what could become the inspiration for the next game developer to follow in it's footsteps and recreate that cinema-style video game, almost setting a new height for the genre in the process and that, my friends, can't be overlooked.
As for the in-game details, There are some areas in the game that do seem a bit much for the game to handle at times but it's not a nuisance in a casual sense. Driving controls and just about anything that isn't on foot can lead itself to become harder than it needs to be but the design for these missions aren't intended to be that of a racing game so keep that in mind when you play this game. More often than not, you may find yourself rushing to use some of your gadgets when you don't really need to and likewise, not rushing to use them when you should... Overall, it's well-polished and in the moment, none of these things really ruined or interfered with the experience in terms of enjoyment so take that as you will.
Now, when it comes to cinema turned video game, there's a lot of misconceptions and bias toward the idea that some movies are better left in their lane. Some people believe in the idea that a story told through the lens of a camera just won't translate well when left in the hands of someone with a controller. Perhaps a certain game company is just lacking the resources or confidence that are essential to creating the mechanics needed or the graphics suited for a self-sustained video game?
The problem here isn't one that a game or even film company is to blame for. The problem here is that you rarely get a group of people to go the extra mile like 007: Nightfire does. When you play this game, it is immediately eminent the time and effort put into every last detail made specifically for your personal enjoyment. I myself have not played any of the other 007 games but after this one of a kind experience, it's definitely something I look forward to mark on my calendar in the
near future.… Expand
Kyle_Katarn92
A great shooter on the PS2. Good story, fun gameplay with lots of variety. The stages are well designed. The multiplayer is a very enjoyableA great shooter on the PS2. Good story, fun gameplay with lots of variety. The stages are well designed. The multiplayer is a very enjoyable experience as well.… Expand
MikeD.
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#66 Best PS2 Game of 2002
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Michael O'Brien (* 13. April 1948 in Plymouth, Devon; † 6. Mai 2015) war ein britischer Historiker. Sein Forschungsschwerpunkt lag auf der Betrachtung der intellektuellen Kultur der US-amerikanischen Südstaaten.

Leben

Jugend, Studium und akademische Lehrtätigkeit
Michael O'Brien wurde 1948 in Plymouth, Devon als jüngstes von fünf Kindern von John O'Brien, einem aus Glasgow stammenden Gastwirt und ehemaligen Seemann, und dessen Frau Lilian, welche aus Cornwall stammte, geboren. Er verbrachte seine Kindheit in Glasgow, Anglesey, London und schließlich South West England. Dort besuchte er die Devonport High School for Boys in Plymouth. Anschließend besuchte er Trinity Hall, ein College der University of Cambridge, und wurde dort von Jonathan Steinberg unterrichtet. 1968 ermöglichte Steinberg O'Briens ersten Besuch in den Vereinigten Staaten, einen Sommerjob in einer Zimmerei in Alabama. 1969 machte O'Brien seinen Abschluss. Kurz darauf im Sommer desselben Jahres heiratete er und zog mit seiner Frau nach Nashville, Tennessee, wo er sein Postgraduales Studium vorantrieb. 1976 promovierte er an der University of Cambridge. Anschließend wurde er die nächsten 25 Jahren an verschiedenen Universitäten in den Vereinigten Staaten tätig. Nämlich an der University of Michigan, der University of Arkansas und zuletzt von 1987 bis 2001 an der Miami University, an welcher er als Professor für Geschichte lehrte. Ab 2001 unterrichtete er an der University of Cambridge, erst als Lecturer, dann als Reader. 2005 erfolgte seine Berufung zum Professor für American Intellectual History. 2008 wurde er zum Fellow der British Academy gewählt.

Sein Buch Conjectures Of Order gewann den Bancroft-Preis der Columbia University, den Frank L. and Harriet C. Owsley Award der Southern Historical Association, den Merle Curti Award der Organization of American Historians, den C. Hugh Holman Award der Society for the Study of Southern Literature und den American Studies Network Book Prize. Des Weiteren war es Finalist für den Pulitzer-Preis für Geschichte. Sein Buch Mrs Adams in Winter war ebenfalls Finalist für den Pulitzer-Preis für Biographie oder Autobiographie.

O'Brien starb im Mai 2015 im Alter von 67 Jahren an einer Krebserkrankung.

Historische Forschung
O'Briens Forschungsschwerpunkt lag, ausgelöst durch seinen ersten Aufenthalt in den Vereinigten Staaten 1968, auf der Geschichte der Südstaaten des 19. und 20. Jahrhunderts und deren intellektueller Kultur. Als er in den frühen 1970er Jahren mit seiner Forschungsarbeit begann, war die Vorstellung der Südstaaten als anti-modern, anti-intellektuell, provinziell und dem Erbe der Sklaverei verhaftet noch weitverbreitete Lehrmeinung. In seinem ersten Buch The Idea of the American South, 1920–1941, betrachtete er, wie es zu dieser Vorstellung, dem Konzept der "Südstaaten" an sich, kam.

O'Brien konnte im Laufe seiner fast 40-jährigen akademischen Karriere zeigen, dass diese Vorstellung nicht zutreffend war und die Südstaaten über eine vielfältige intellektuelle, kosmopolitische Tradition verfügten. Dies gipfelte, nach einer Vielzahl von Veröffentlichungen, in seinem 2004 erschienenen zweibändigen Werk Conjectures of Order: Intellectual Life and the American South, 1810–1860.

Veröffentlichungen (Auswahl)
 The Idea of the American South, 1920-1941 (1979)
 (Hrsg.): All Clever Men, Who Make Their Way: Critical Discourse In The Old South (1982)
 A Character Of Hugh Legare (1985)
 mit David Moltke Hansen (Hrsg.): Intellectual Life In Antebellum Charleston (1986)
 Rethinking The South: Essays In Intellectual History (1988)
 (Hrsg.): An Evening When Alone: Four Journals Of Single Women In The South, 1827-67 (1993)
 Conjectures Of Order: Intellectual Life and The American South, 1810-60 (2004, 2 Bände)
 Henry Adams and the Southern Question (2005)
 Placing the South (2007)
 Mrs Adams in Winter: A Journey in the Last Days of Napoleon (2010)

Weblinks

 Michael O'Brien obituary, 14. Mai 2015, The Guardian

Historiker (Neuere und Neueste Geschichte)
Hochschullehrer (Miami University)
Hochschullehrer (University of Cambridge)
Mitglied der British Academy
Brite
Geboren 1948
Gestorben 2015
Mann

redpajama_set_name: RedPajamaWikipedia


The other crock holds everything else needed to prepare well. Whisks, a manual can opener, a pair of scissors, any kind will do. You will pay much more for a pair of scissors if it says kitchen on it. I simply buy regular everyday scissors, they work just fine. There are my soup ladles, both plastic and metal, slotted spoons, metal whisks and some odds and ends. I do not place knives or forks in here because when you reach for a soup ladle it may poke you and that is uncomfortable. I always have a bathroom drawer close to the stove for my hand grater, pot holders, quick knives; my trusty little knife sharpener, a melon baller, a non electric potato masher, etc . I do not really see a reason to have a unique pastry brush when a innovative, clean paint brush functions just as well or the meat mallet; I have always used a hammer and cover the meat with plastic wrapping. I do not use measuring spoons and a cup, a teaspoon is a tablespoon; I use my one a glass measuring cup for all kinds of things. And what is an egg separator? And a cake tester? Use a toothpick for crying out loud. A coffee information is always in the coffee planting container. Of course you can equip the kitchen the way you want to, but to save a bit of money to start with, use common items, they always work plus the prices are pretty cheap.
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Home Football World Cup 2022 2022 WORLD CUP INJURY LIST: Update on players' injury per country
2022 WORLD CUP INJURY LIST: Update on players' injury per country
Joseph Shalom
The hosts have no significant injury concerns with forward Ahmed Alaaeldin expected to be fit to face Ecuador after going off in the first half of last week's 1-0 warm-up win over Albania.
Robert Arboleda has only recently returned from a fractured ankle but should be fit for the opener against Qatar and could start at right back.
Jeremy Sarmiento has a slight muscle issue with midfielder Carlos Gruezo expected to start after a thigh problem.
This year's African Nation's Cup winners were dealt a hammer blow on the eve of the tournament when striker Sadio Mane was ruled out of the tournament.
The Bayern Munich star, who joined this summer from Liverpool, underwent knee surgery after suffering an injury during his club's Bundesliga win over Werder Bremen on 8 November.
Abdou Diallo (knee) is doubtful for the side's opener against the Netherlands, but the absence of their best player will be difficult for the 'Lions of Teranga' to overcome.
Dutch coach Louis van Gaal has said Memphis Depay will not start against Senegal after his recovery from a hamstring injury, but it is merely a precaution with the Barcelona forward expected to play a full role after that.
Inter right back Denzel Dumfries is fit after hurting his knee against Atalanta last week.
Georginio Wijnaldum misses the World Cup after suffering a broken leg while playing for Roma in August.
Experienced right back Kyle Walker will skip England's opener against Iran after recovering from recent groin surgery. But the Manchester City player is confident he will be fit for the rest of the World Cup.
That is a welcome boost for coach Gareth Southgate after Reece James was ruled out of the tournament with a knee injury.
Leicester City midfielder James Maddison has recovered from his knee injury which forced him off in the first half against West Ham last Saturday (12 November).
Sardar Azmoun was named in Iran's squad by Carlos Queiroz despite having been out of action since tearing a calf muscle at the start of October.
With 41 goals from 65 international appearances, the Bayer Leverkusen striker is vital to Iran's hopes in Qatar but only 50-50 to make the opener against England.
Omid Ebrahimi is out of the tournament after suffering a groin injury in the friendly against Nicaragua last Thursday (10 November).
Juventus midfielder Weston McKennie is USA's biggest doubt ahead of the opener against Wales with a thigh muscle injury.
While he is expected to play some part, McKennie is unlikely to start with Luca de la Torre – also recovering from a muscle injury – set to deputise.
Crystal Palace central defender Chris Richards was ruled out two weeks before the tournament with a leg injury sustained in August.
Captain Gareth Bale made a spectacular return to action for LAFC two weeks ago, scoring a header in extra-time to help his side win the MLS title.
The former Real Madrid and Tottenham star is not 100 percent fit, but he is expected to play a full part in Qatar regardless.
Veteran midfielder Joe Allen returned to training on Thursday after two months out with a hamstring injury.
Coach Rob Page has an otherwise fully fit squad after Rhys Norrington-Davies (hamstring) was ruled out.
Fiorentina forward Nicolas Gonzalez will play no part in the World Cup after suffering a muscle injury in training on Thursday (17 November) with Atletico Madrid's Angel Correa coming into the squad.
Inter's Jorge Correa has also been ruled out by injury with the Inter forward replaced by US-based Thiago Almeda.
Could Lionel Scaloni could be forced into more changes with Tottenham defender Cristian Romero, Sevilla forward Papu Gomez and Roma attacker Paulo Dybala all battling injuries having missed the side's last warm-up match against UAE on Wednesday (16 November).
Coach Herve Renard has the luxury of a full squad to choose from with captain Salman Al-Faraj making a speedy recovery from a shoulder injury.
The Al-Hilal playmaker was replaced at halftime in the 1-0 win over Iceland on Sunday (13 November), but started Wednesday's 1-0 friendly defeat to Croatia.
London 2012 gold medallist Raul Jimenez could have a significant role for Mexico in this World Cup after playing the second half of the team's friendly against Sweden on Wednesday 16 November).
A succession of injuries has restricted the Wolves striker – who suffered a life-threatening skull fracture against Arsenal in November 2020 – to just four appearances this term with club boss Julen Lopetegui saying he did not think Jimenez should go to Qatar.
Sevilla winger Jesus Corona missed out on the squad with an ankle injury.
Goalkeeper Bartlomiej Dragowski will play no part in Qatar after breaking his ankle in horrific fashion while playing for Italian Serie A side Spezia against Verona last Sunday (13 November).
He has been replaced in the squad by FC Copenhagen's Kamil Grabara.
Brighton midfielder Jakub Moder misses the tournament after tearing his anterior knee cruciate ligament in April.
Andreas Christensen is Denmark's only worry ahead of their opener against Tunisia with the Barcelona defender recovering from ankle ligament damage sustained last month.
Brentford midfielder Christian Norgaard coming on as a substitute in the shock win over Manchester City last Saturday (12 November) after Achilles trouble.
RB Leipzig striker Yussuf Poulsen also came on as a replacement last weekend having recovered from a muscle injury.
Manchester United's Christian Eriksen is in the squad 17 months after he suffered a cardiac arrest on the pitch at Euro 2020.
Tunisia have no injury worries ahead of their opener against Denmark with star striker and captain Yousef Msakni – who missed the 2018 World Cup through injury – recovering from a knee injury to take his place in the squad.
Having missed much of the season through injury, Real Madrid star striker Karim Benzema was ruled out of the World Cup on Saturday (19 November).
The Ballon d'Or winner suffered a left quadriceps injury during training with coach Didier Deschamps later confirming that 34-year-old Benzema would play no part in the tournament.
This latest blow comes just three days after RB Leipzig striker Christopher Nkunku twisted his leg in training with Eintracht Frankfurt's Randal Kolo Muani replacing him in the squad.
Raphael Varane remains a major doubt for France's opening match against Australia with the reigning champions already without the likes of Paul Pogba and N'Golo Kante in Qatar.
Scotland-based winger Martin Boyle is the Socceroos' biggest doubt at the start of the tournament after he injured his knee playing for Hibernian last month.
Melbourne City's Marco Tilio has been flown to Doha in case Boyle fails to recover, while Harry Souttar and Ajdin Hrustic only took part in light training on Thursday (17 November).
The 2014 champions are without star names Marco Reus and Timo Werner, both due to ankle injuries, while Barcelona goalkeeper Marc-Andre ter Stegen missed the 1-0 friendly win over Oman on Wednesday (16 November) with a gastrointestinal infection.
RB Leipzig defender Lukas Klostermann lasted just 34 minutes of that win and, while coach Hansi Flick insists substituting him was purely precautionary, Klostermann's historic injury-proneness makes this development somewhat concerning especially as right back is a position in which Germany lack depth.
Central defender Nakayama Yuta, who plays for Huddersfield in England's second tier, misses the World Cup – and the rest of the season – after undergoing surgery on his Achilles tendon at the start of the month.
After almost two months out with a knee injury, VfL Bochum striker Asano Takuma returned to action in the 2-1 defeat to Canada in Dubai on Thursday (17 November), but Mitoma Kaori (illness), Endo Wataru (concussion) and Morita Hidemasa (calf) stayed at the squad's camp in Doha to continue their rehabilitation.
Valencia left back Jose Gaya was ruled out of the tournament on Friday (18 November) after spraining his ankle in training on Wednesday night.
Gaya, whose fitness was assessed after the squad landed in Qatar, will be replaced in the squad by Barcelona teenager Alejandro Balde.
In the build-up, Real Sociedad winger Mikel Oyarzabal was the one major loss to coach Luis Enrique as he continues his recovery from a ruptured knee cruciate ligament.
Atletico Madrid midfielder Koke sustained a thigh injury in mid-October, but resumed full training last week with Enrique hinting that the 30-year-old may start the opener against Costa Rica.
Goalkeeper Keylor Navas has not played a competitive match since June, with Italian Gianlugi Donnarumma in possession of the gloves at Paris Saint-Germain.
That is something of a worry for the Ticos who have no injury worries to speak of.
Marseille midfielder Amine Harit was ruled out of the World Cup after he was stretchered off with a serious knee injury against Monaco last Sunday (13 November).
He has been replaced by Anass Zaroury of English second-tier club Burnley, but it is a big blow for the Atlas Lions who were already without Imran Louza of Burnley's Championship rivals Watford.
West Ham centre back Nayef Aguerd is fit after recovering from ankle surgery.
Defensive midfielder Marcelo Brozovic returned for Inter's last three games before the World Cup break after a hamstring injury.
After a brief injury scare last weekend, AEK Athens defender Domagoj Vida came on midway through the second half against Saudi Arabia on Wednesday (16 November) to make his 100th international appearance.
Following that 1-0 win in Riyahd, coach Zlatko Dalic has no injury concerns ahead of the tournament with the team – who were runners-up
four years ago in Russia – set to be skippered by 37-year-old Luka Modric.
AC Milan winger Alexis Saelemaekers has just failed to recover in time from a knee injury to be fit for the World Cup.
Meanwhile, Romelu Lukaku was included in the squad despite a thigh injury with coach Roberto Martinez hoping to have the Inter striker back for the team's third group game against Croatia.
Thomas Meunier is fit despite suffering a fractured cheekbone while on duty for Borussia Dortmund in mid-October.
LAFC goalkeeper Maxime Crepeau was ruled out of the World Cup earlier this month when he broke his leg in committing a foul which saw him sent off in the MLS Cup Final.
Doneil Henry is also out after picking up an injury warming up ahead of the friendly against Bahrain last Friday (11 November) and joins fellow defender Scott Kennedy (shoulder) on the sidelines.
Bayern Munich star Alphonso Davies is in the squad, and he is confident of making the side's opener against Belgium after a hamstring injury which saw him limp off against Hertha Berlin on 5 November.
The only injury worry for coach Murat Yakin lies in the goalkeeping department. But it's a serious one with Borussia Moenchengladbach's Yann Sommer out of action since tearing ankle ligaments in October.
While the veteran stopper has been named in the squad, there are three other goalies in Yakin's 26 with usual backup, Lorient's Yvon Mvogo, missing out after sustaining a knee injury two weeks before the tournament against Paris Saint-Germain.
Coached by former Liverpool defender Rigobert Song, the Indomitable Lions have no reported injury concerns ahead of the World Cup.
Missing from Brazil's squad is Juventus midfielder Arthur Melo, currently on loan at Liverpool, who has a thigh injury which looks set to rule him out until the New Year.
There were two injury scares from the squad's first training session in Turin on Wednesday (16 November) with Newcastle midfielder and Rio 2016 gold medallist Bruno Guimaraes, on his 25th birthday, requiring treatment after Real Madrid forward Rodrygo stepped on his foot.
Sevilla defender Alex Telles also needed attention after he was tackled from behind by Paris Saint-Germain superstar Neymar.
The pair will be assessed further on Monday after their arrival in Doha.
Coach Dragan Stojkovic has concerns in attack with Juventus striker Dusan Vlahovic out of action for the past month with an adductor injury.
Fulham target man Aleksander Mitrovic has also missed games in recent weeks, with an ankle problem, but Serbia's all-time leading scorer has also been named in the squad for Qatar.
Ronald Araujo has made a rapid recovery from thigh muscle surgery in September to be included in coach Diego Alonso's squad, but he is somewhat doubtful for the side's opener against Republic of Korea.
Veteran striker Edinson Cavani missed Valencia's last two games before the World Cup break with an ankle injury but is expected to play a full part in Qatar.
One player who is missing from the squad is Getafe midfielder Mauro Arambarri who underwent ankle surgery last month.
Son Heung-min has made it to Qatar despite fracturing his eye socket while playing in Tottenham's Champions League win over Marseille earlier this month.
The star forward has been wearing a protective face mask in training, and time is on his side with South Korea's opener against Uruguay not until Thursday 24 November.
Portugal are missing three English Premier League players with the biggest absentee Liverpool forward Diogo Jota who suffered a calf injury just after recovering from hamstring trouble.
Fernando Santos is also without Wolves winger Pedro Neto (ankle ligament damage) and Ricardo Pereira who ruptured his Achilles in Leicester City's pre-season friendly against Sevilla.
Most of the build-up has been dominated by Cristiano Ronaldo's explosive interview on British television in which he criticised Manchester United and manager Erik ten Hag. The club is reportedly seeking to terminate the superstar's contract, which expires at the end of the season, with immediate effect.
Spezia captain Emmanuel Gyasi is out of the World Cup with the muscle injury which saw the forward miss his club's trip to AC Milan just hours before kick-off on 6 November.
Defender Stephan Ambrosius, on loan at German second-tier side Karlsruher from SV Hamburg, is also on the sidelines with a thigh injury.
Rennes flyer Kamaldeen Sulemana (ankle) and SC Freiburg forward Daniel Kofi Kyereh (muscle) were both deemed fit enough to be included in the squad, but coach Otto Addo has issues in goal with injuries ruling out English-based number one Jojo Wollacot and usual backup Richard Ofori.
SOURCE: olympics.com
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Fansite
Fra Fee
Official website for actor Fra Fee
Fra will star as Mole in the hugely anticipated major musical adaptation of The Wind in The Willows with a book by Julian Fellowes (creator of Downton Abbey) and music and lyrics by Stiles & Drewe (Mary Poppins). Fra stars alongside Rufus Hound as Toad, Thomas Howes as Ratty and Neill McDermott as Weasel. The production plays Plymouth, Southampton and Manchester before hopefully finding a West End home in 2017. Full details can be found at www.thewindinthewillowsmusical.com
Fra stars as Cal Chandler in the inaugural production of the Union Theatre's brand new, state-of-the-art home: the triumphant return of Michael Strassen's critically acclaimed production of THE FIX.
When the most popular presidential candidate dies between his mistress's thighs his status-starved widow, Violet, decides that if she can't be the wife of the president, she'll be his mother!
Thrusting her lacklustre son Cal into the spotlight, Violet is determined to create the perfect politician at any cost in this brutally comedic tale of lust, greed and scandal. With a rock-fuelled score, laced with scandalous lyrics, the team behind The Witches of Eastwick deliver a dark and spellbinding ride through the American political machine.
The Fix runs at the Union Theatre from July 13th until August 6th and stars Fra Fee, Madalena Alberto and Lucy Williamson.
Fra plays Amiens in the National Theatre's production of As You Like It, by William Shakespeare directed by Polly Findlay from October 2015 until 6 March 2016. Keep a look out for this production being broadcast live to cinemas across the UK.
Fra appears in PUTTING IT TOGETHER, a Stephen Sondheim review at the Lyric Theatre, Belfast from 9-19 December (excluding the performance on December 15). The cast is completed by Carol Starks, Nicholas Pound, Brad Clapson and Christina Tedders.
'Being Alive' from Stephen Sondheim's Company, sung by Fra Fee, Bradley Jaden, Laura Pitt-Pulford, Alistair Brammer and Janie Dee, conducted by Alex Parker. Tickets now on sale for Kings of Broadway at the Palace Theatre 29 November 2015.
Fra plays Jamie in The Last Five Years alongside Amy Lennox as Cathy at the Lyric Theatre, Belfast from June 24 - July 4, 2015.
Fra plays Romeo in Shakespeare's Romeo & Juliet directed by Wayne Jordan at Dublin's Gate Theatre from March - May 2015.
A one night only concert performance of and Hugh Wheeler's critically acclaimed and award-winning musical A LITTLE NIGHT MUSIC played the Palace Theatre in London's West End, with Fra playing the role of Henrik Egerman.
Fra plays the role of Kieran in Tom Lawes' feature film Monochrome, starring alongside Jo Woodcock, Cosmo Jarvis and James Cosmo. Monochrome is set for a limited release in 2015.
Cluasóg Videos Released..! See below for Cluasóg's recent live recordings of 'The Lakes of Ponchartrain' and 'Gleanntáin Ghlas' Ghaoth Dobhair'...
My Cousin Rachel - Dock Street Theatre / Spoleto Festival, Charleston USA
Dublin's consummate Gate Theatre pairs their signature sophistication with Hitchcockian suspense in Daphne du Maurier's My Cousin Rachel. We follow the young Philip Ashley as he comes to terms with his wealthy guardian's unexpected demise. Philip suspects his cousin's widow Rachel of foul play, but falls madly in love with her while investigating the death. Both Philip and the audience must decide: is she a devastated widow or sinister villain? Du Maurier's spellbinding melodrama delivers humor, lust, and paranoia—a whodunit at its finest.
Fra most recently starred as Philip in the Gate Theatre, Dublin's American revival of My Cousin Rachel adapted for the stage by Irish novelist and playwright Joseph O'Connor. The play ran from May 22 until June 8th at the Dock Street Theatre, Charleston, South Carolina.


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Q: Google Service to Service Authentication Not Working I'm attempting to have my php application call Google's Calendar API using the service to service authentication.  I have administrative access over my Education G Suite, and have performed the following steps as indicated here: https://developers.google.com/identity/protocols/OAuth2ServiceAccount

*

*Created a service account with domain-wide authority, and saved the proper credentials.

*Added the Calendar (Read-Write)  https://www.googleapis.com/auth/calendar scope to my admin account under "Managed API Client Access" using my ClientID (which is confirmed by the UI)

*Made the proper calls to the php API client, attempting to both impersonate the admin and another user account, per the examples
here: https://developers.google.com/api-client-library/php/auth/service-accounts
However, when I attempt to obtain any calendar information I continue to get the following error:

Google_Service_Exception: { "error": "unauthorized_client", "error_description": "Client is unauthorized to retrieve access tokens using this method." }

Per googling, this would typically mean that I haven't delegated domain-wide authority, but I definitely have.  I've tried other Google apis with the same results.
Here's my code.  Thanks for any thoughts or help.
<?php require_once __DIR__ . '/vendor/autoload.php';
putenv('GOOGLE_APPLICATION_CREDENTIALS=****/client_secret.json');

$user_to_impersonate = 'user@****.com';
$user_scopes = array(
    Google_Service_Calendar::CALENDAR
);
$client = new Google_Client();
$client->useApplicationDefaultCredentials();
$client->setSubject($user_to_impersonate);
$client->setScopes($user_scopes);
$client->setAccessType('offline');

$calendar = new Google_Service_Calendar($client);
$calendarId = 'primary';
$optParams = array(
    'maxResults' => 10,
    'orderBy' => 'startTime',
    'singleEvents' => TRUE,
    'timeMin' => date('c'),
);
$results = $calendar->events->listEvents($calendarId, $optParams);
...

?>

A:
Client is unauthorized to retrieve access tokens using this method.

When you create your project on Google developer console you should have created service account credentials.  You would then be promoted to download a file this file contains the credentials for a service account.
The code you use to connect to a service account is different then the code use to connect using browsers or native client credentials.
ServiceAccount.php link to code
require_once __DIR__ . '/vendor/autoload.php';
// Use the developers console and download your service account
// credentials in JSON format. Place the file in this directory or
// change the key file location if necessary.
putenv('GOOGLE_APPLICATION_CREDENTIALS='.__DIR__.'/service-account.json');
/**
 * Gets the Google client refreshing auth if needed.
 * Documentation: https://developers.google.com/identity/protocols/OAuth2ServiceAccount
 * Initializes a client object.
 * @return A google client object.
 */
function getGoogleClient() {
    return getServiceAccountClient();
}
/**
 * Builds the Google client object.
 * Documentation: https://developers.google.com/api-client-library/php/auth/service-accounts
 * Scopes will need to be changed depending upon the API's being accessed.
 * array(Google_Service_Analytics::ANALYTICS_READONLY, Google_Service_Analytics::ANALYTICS)
 * List of Google Scopes: https://developers.google.com/identity/protocols/googlescopes
 * @return A google client object.
 */
function getServiceAccountClient() {
    try {
        // Create and configure a new client object.
        $client = new Google_Client();
        $client->useApplicationDefaultCredentials();
        $client->addScope([YOUR SCOPES HERE]);
        return $client;
    } catch (Exception $e) {
        print "An error occurred: " . $e->getMessage();
    }
}

You appear to be using the correct service account code.  However you have probably downloaded the wrong credentials file i suggest you download the file from Google developer console again.

A: Had added incorrect scopes in step 2 above. Hopefully this still allows some folks to see the right steps.

A: I have also run into this problem but only when using $client -> setSubject(impersonationemail);
Try commenting out this line and see what response code it gives you.

redpajama_set_name: RedPajamaStackExchange


Did you know how easy it is to search for members within XLCubed?
Here's a simple grid – let's search for members within the Geography hierarchy.
First of all, let's open the Geography member selector by just double-clicking the Geography header.
XLCubed offers a number of options when searching.
Firstly, you can simply enter a search term in the box before clicking the first of the icons within the green border.
That will find the first entry in the hierarchy – drag across to include in your grid report.
Click the second icon to find the next member that fits the search criteria – you can also cycle back to find the previous member(s) if needed by clicking the third icon in this group.
You can determine which Property to search by as well as setting options for case sensitivity.
You can also set restrictions on the levels that will be searched.
Let's search for all hierarchy members that contain the string 'di'.
As you can see all hierarchy members containing the string 'di' have been returned.
Click the button to the left of Member to select all members or pick individual members and then click Pick.
The search value can also be in an Excel range so that dynamic searching is possible.
If this value changes then the grid updates accordingly. If you want to use this functionality in a published report, remember to unlock the Excel cell so that new values can be entered in the web report.
We hope you've found this blog useful and as always, we value your feedback.


This easy-to-install trunk-mount bike carrier has six straps for a secure and stable ride.
Bike capacity: Up to 3 bikes.
Easy to install and exceptionally stable.
New antisway cradles won't scratch bikes.
Patented Fit Dial lets you to find the perfect fit for your vehicle in just minutes.
This rake is the best in its line!! I LOVE IT!!! As we drive we see a lot of bike carrier with the THULE name so I know WE HAVE SOMETHING AWESOME!!!
Great bike rack if you don't have a trailer hitch, very stable/secure compared to others I've used. Good price and shipped for free!
Light, easy to install and take off when I don't use it.


Numbers are neither difficult to understand nor it is difficult to manipulate only if teachers are able to impart confidence in students by making it interesting for them to learn. The bulk of responsibility to make mathematics attractive to children rests with teachers. Teachers should first love the subject and be able to proliferate it through their actions that children could witness as live demonstration. This is when they realize how easy it could be to grasp the numbers that seemed quite faraway objects earlier. How mathematics can be taught effectively has been discussed in this article.
The better you are aware about why to teach mathematics, better you are placed to teach it effectively. Mathematics is wound around our daily lives and most life skills require the knowledge of mathematics. Students have to be imparted the knowledge in a way so that they can make use of numbers and the processes to understand many more information that surrounds their lives. Whether you are teaching mathematics in school or giving home tuition the goals of teaching are same. Clarity of goals will lead you to innovative ways to teaching that generates interest and drives away inhibitions of students that surround the subject.
The numbers that are seen on the surface convey different meanings depending on how it is made use of. Numbers are manipulated to define some mathematical concept that is illustrated by some defined procedures. Children have to be told about the concept that is being taught. This means that they have to be taught about why 2x2 makes 4 or why 3+3 makes 6. At the same time they have to be taught about the processes which are the ways numbers have to be added, subtracted, multiplied and divided. This would explain how it happens. Children have to understand why it happens and also how it happens. This would lend clarity about both the concept and the process so that students can make some sense of it.
While it is important to ensure that students are able to grasp the process of doing mathematics it is even more important to make them understand the various concepts that make things happen. Keep asking them about why some things work and why other does not. Unless a student has clarity about why and how numbers work, they can never enjoy the hidden treasures of mathematics that can make it attractive to them. Never be bound by the correct answer only but stress on what has been done right in the process. This would help to identify the strength and weakness of students that has to be worked upon.
Impart confidence in students by stoking their creativity by allowing them to practice some mental mathematics in explaining and solving problems. This would make them feel more confident and develop a sense of meaningful association with the subject and make them feel like mathematicians.
Teachers have to be more sensitive and innovative to make mathematics lovable to students.


For starters, this system will likely include courses on community engagement and active citizenship. Questions concerning the prescriptions are referred for the pharmacist, however the pharmacy technician handles other duties for example filling the prescriptions, stocking the shelves, cashiering, delivering medical devices, reviewing information in order to avoid drug interactions and verifying received prescriptions. The big databases give you different questions another time you undertake the sample pharmacy technician exam.
Heading to pick up prescriptions, allergy relief, slimming aids or pain relief might be annoying whatever some time of year, especially in case you have to take time out of your respective busy schedule to visit your nearest pharmacy which can be inconveniently located. An Internet pharmacy is simply an online store; an online site that sells medicines around the web. Fresh herbs are best to the tinctures and oils recommended with this book.
A wholesale purchase will prove a lot helpful for those who are having large family. This is when a lots of problems are encountered but it is important to remember it's almost always never the pharmacy's fault that a claim has been rejected. In the situation of pharmacy specialist jobs, giving an unacceptable prescription is the widespread error that is certainly certainly mostly documented.
It doesn't seem fair people do not have cheap drugs available to them for purchase and that these are burdened with spending the entire content of their life worrying about something which could affect their survival like this. " A good response to this isn't "I'm trying to find a job. Veri - Sign and Scan - Alert Hacker Safe would be the two names you should be looking out for as well because they names will proclaim that these websites are safe for paying online.
'	Sri Venkateshwara College of Pharmacy - Hyderabad. Luckily, you'll find Rx discount cards, coupons, and savings programs which could save you quite a lot of money, and most are easy to find and manage. Success is not only good luck: it is a combination of hard work, good credit standing, opportunity, readiness and timing.


A columnist for the LA Times claims America is falling out of love with billionaires. I am not sure that is true. First off, we need to recalibrate the definition of the American Dream. Right now, it seems that for many the American Dream is to get wealthy.