Live scribing and digital scribing happen in the room of the event.
Digital scribing uses tablet technology and an online gallery to share the artwork. This is a great option if social media is incorporated into your event. Remote scribing is dialled into the event from an outside studio and typically appears on a large screen in the event, or it can also appear online. For example, we have remoted in from London to New York, New York to Switzerland and London to Hamburg.
How do I work with the scribe in the room?
We're a friendly lot. If you want to give some input whilst the scribe draws - perhaps to explain any acronyms that pop up or to give additional context - step right up and whisper in their ear or put your idea on a post-it.
Do you supply the artist's material?
Yes, we can supply the artist's material if you prefer.
What do your expenses include?
Expenses can include specialist resources such as pens, paper or foamboard as well as travel and accommodation. We only ever charge you at cost what we incur and we sign off expenses with you. If using a local scribe, we estimate that expenses are 5% - 10% of the booking fee. If national or international travel is involved, we estimate that expenses are 10% - 20% of the booking fee. Please get in touch to discuss your project further.
Does it happen in real time?
Yes, our artists draw at the same time as the content is presented. But, the live scribe process isn't like an RSA animate where the voice and the image happen simultaneously. Rather the scribe listens, processes and draws their interpretation. Because we have discussed beforehand the key messages and purpose of the event, the scribe uses the brief as a compass from which to interpret what they hear.
How can you scribe the key messages of a subject that you aren't an expert on?
Our scribes are not experts on car manufacturing, global economics or talent frameworks. They are brilliant listeners and interpreters which is why are they able to pull out ideas to make new connections and get to the heart of a story.
We can adapt to the needs of your venue. If you only have enough space for a flipchart, then we can use a flipchart. Or if you want us to create a big mural on a wall, we can do that too.
Do you need to know about the content before contacting?
It would be helpful for us to know the topic for the event. The scribe will capture the message in the room.
What might an output look like?
It all depends on what your event is. We can create knowledge walls, product life-cycles, timelines, vision boards, commitment boards, roadmap, t-maps, business models, day in the life, customer experience journeys, visualise conversations, presentation, pitches. Really the list goes on so best to tell us more about your event and we'll work out how we can draw it.
Imagine your event from beginning to end drawn up like a mural.
When can I expect the digital outputs?
We usually take between 1 - 3 working days to turn around the digital versions. If you want the scribe images turned around on the same day, we can do this, but it often requires an additional cost.
What types of things you do?
Branding, illustration, rich picture infographics, interactive graphics, brochures communication campaign.
We work with all types of companies, from local to international companies. You may refer to our client list for reference.
All work we carry out is completed internally.
Can you create a brand, build a website and help us grow the business?
Absolutely! Our core focus is helping people launches successful businesses. That means working closely with clients to create a strong brand, build an engaging website and put together a long-term digital marketing strategy to help promote what they do to the right people. Our goal is to remove the complications and delays when working with lots of different people by providing you with a single point of contact and a reliable set of services.
How do you handle meetings?
It really depends on the size of your project. Throughout the project we can schedule numbers of Skype meetings to discuss progress and listen to any feedbacks you have for us.
What types of films do you create?
We create films for a wide variety of purposes and initiatives, ranging from one-off promotional product or service videos to multi-channel communication or engagement campaigns. Our global network of filmmakers is experienced in creating interactive films, branded content, as well as event coverage and animations that influence, engage, and inspire diverse audiences.
In simple terms, an interactive video is one that requires active participation from the user. This could be as simple as pressing / clicking a button onscreen, answering a question, or making a decision - anything that requires input and informs what happens next. It differs from traditional video as the user becomes an active participant in your story, allowing them to form their own journey or explore content at their own direction and pace.
What does the film process look like?
The exact production process can vary depending on the type of film we are creating. However, the foundations remain the same. As with every project we deliver, we use a collaborative, iterative process with multiple touch points to provide ample opportunity for feedback. Typically, we begin with scripting and storyboarding before moving to the filming and editing process. We then iterate several drafts of the video based on your feedback to sculpt the perfect version of your story.
Unfortunately, there is no universal answer to this question. It very much depends on the type and scale of production. For example, an event film may only take a few days to complete, whereas a large campaign film with lots of special effects could take months. Prior to commencing any project, we provide a delivery schedule outlining timelines and key milestones. We are also happy to suggest ways to expedite certain elements of the process to turn around a film in a shorter space of time.
How much does a film cost to make?
In short, it depends on various factors such as scope, duration, location and complexity of the production. We are always happy to make recommendations and provide a range of options to tailor a video to your budget. Feel free to get in touch to discuss your requirements and we will provide a proposal.
Are there any other costs associated with creating a film?
All our production costs are transparent and available upfront. However, there may possibly be additional expenses as part of a project such as logistical elements (travel, accommodation etc) or production costs (music licensing, voiceover artist fees etc). We always make it clear if these are required and provide a range of options before proceeding. Typically, we estimate that expenses are 5% - 10% of the project value.
What styles of animations do you create?
We create a wide range of animations, from whiteboard to explainer style videos to motion graphics and fully realised 3D pieces. Plus, our global network of scribes means we can find the ideal illustration style to bring your story to life. And if you feel really lost, we have a demo reel we can share to help pick out your preferred animation style.
What does the animation process look like?
As with every project we deliver, we use a collaborative, iterative process with multiple touch points to provide ample opportunity for feedback. The animation process itself starts with scripting and storyboarding before moving through to creating the artwork and then animating it to bring the visuals to life. We then iterate several drafts of the video based on your feedback to sculpt the perfect version of your story.
It can vary, depending on factors such as length and complexity, but generally we recommend allowing 3-4 weeks to create an animation. We find this allows for a relaxed iteration and sign-off process, without the need to rush creative decisions. However, certain elements of the process can be expedited to turn around a video in a much shorter space of time.
How much does an animation cost to make?
In short, it depends on factors such as style, duration and animation complexity. We are always happy to make recommendations and provide a range of options to tailor a video to your budget. Feel free to get in touch to discuss your requirements and we will provide a proposal.
Are there any other costs associated with creating an animation?
All our production costs are transparent and available upfront. The only additional expenses that may be incurred as part of an animation project are music licensing and voiceover artist fees, if required. We always make it clear if these are needed and provide a range of options before proceeding. Typically, we estimate that expenses are 5% - 10% of the project value.
What sort of games do you produce?
We create games online or offline games to help businesses to promote transformation journeys and strategies for engaging employees and collaborative and competitive gamified learning.
What digital platform do you build games for?
Our game can be browser base – responsive for desktop, laptop, tablet and mobile. Or they can be app based for employees to download for your company app store.
Do your games capture data securely?
We take your security very seriously, and all of our games are GDPR compliant.
What is the maximum number of people who can play your games simultaneously?
Our games can support communities of tens of thousands of people playing at the same time.
Can your digital games embed other media?
Yes! We can host videos, sound files etc. Please see our film page to help you with those needs.


A journey discovering the essential essence of Herbs during my apprenticeship at Springfield Sanctuary.
Research the structure & function of skin. How does a bruise form. What herbs can be used to help bruises.
Research structure of human blood cells. How does horse-chestnut help to strengthen them.
Research & note the meaning of the following term: expectorant, astringent & bitter.
Winter: Collect rosehips & sloes to make a single syrup or combination ssyrup flavoured either with lemon, spices &/or make a rosehip honey.
Heartfelt thanks to Sarah Head. Delighted to be part of the apprenticeship group of Herbhuddies :) Such a delightful gathering of supportive, caring, warm, peaceful & loving peeps. Looking forward to many discoveries. Especially as I am a complete beginner!!
Hello there, Journals of life, passions, pleasures, trials & tribulations - joys, journeys & celebrations by a friendly English Lady living in England. Globe trotting the world in love, vision & spirit. Daughter of the Universe. Slave to creativity, to love, to the kitchen, a passionate Chef de Cuisine :) Home - any place in which all things are created with Love . . Blogging as a daring modality perhaps to share the vision - etch a memory - an echo of love & an imprint of happiness reaching the open hearts on the realms & highways of life. A legacy of Love .. and of course a few home made recipes for your pleasures. Latest instalments of my dabbles into Herbalism :) Welcome.


how does it go again? I keep forgetting!
and for those who have gone straight back on after PCT, do you find that gains are restircted compared to waiting say 3 months later to go back on - does that make sense?
I'm thinking about going back on but my gains have stopped at present. I've been very disapointed with this cycle TBH, I've only gained 9lbs in 6 weeks.
i see what you mean, ive jumped back on twice in the past and neither had worse gains than if I had waited tbh.
I jumped back on and still had greta gains this time, check out the journal for how it went.
I'm wanting to take a full year off gear (starting from january) so was thinking about jumping straight back on.
Thing is, my gains have stopped on this cycle - is there any way to correct this? or should I just stop this cycle, do PCT, wait a couple of weeks then jump back on?
100mg Ed ...you show off cu*t, thats it Im upping mine to 120.
why I otta.... cant be ar5ed tho. you beast in.


"We are on the brink of enacting historical legislation that would fix the way we fund schools in Illinois. Our state's inequitable formula has failed the students of our state for decades, and today I voted to change that because I refuse to keep failing.
completed application and required documentation by July 15, 2017.
Effective July 1, 2017, Any person who has been honorably discharged who served in a combat mission by proof of hostile fire pay or imminent danger pay during deployment on active duty, or has served 3 years of full active and continuous military duty and received an honorable discharge, meets the collegiate educational requirement of the Department of StatePolice.
SPRINGFIELD – High-poverty suburban school districts, shortchanged for decades under Illinois' worst-in-the-nation education funding formula, could see a significant influx of funding to level the playing field with wealthier suburban districts under a landmark school funding reform measure that recently passed in both houses of the legislature.
"I eagerly joined my colleagues in support of a plan that fixes the inequitable way we fund public schools in. It also makes sure no schools see any loss of funding and offers property tax relief to struggling homeowners. There is no reason Governor Rauner should not sign this legislation as soon as it gets to his desk," Illinois said State Senator Napoleon Harris (D-Harvey).


It's easy to get blinded these days by all the talk about cloud, SDN and automation leading both new and existing people in networking to make decisions in their career which may not be the best ones long term. I've had the pleasure of interacting and working together with a lot of prominent people in the industry. Based on this I have identified some skills that all of these people have to some degree and that I believe to be crucial to succeeding in the IT industry.
Ability to write – Many of the successful people in the industry like Ivan Pepelnjak, Russ White, Nick Russo and so on have either authored books, write blogs or both. The ability to put your thoughts down into writing is critical. For someone like me that is working in network design, it is probably the most important skill, not only to write technical documents but to interact with customers, colleagues, managers and so on. It doesn't matter if you are a technical savant if you can't put a brief document together describing why and how a certain technology should be implemented.
Ability to speak – A lot of people in IT are a little introverted, myself included. I've worked hard on becoming more comfortable with speaking and interacting with people in different environments. Why is this important? In order to build a successful career you can't do it on your own. You will need to interact with customers, colleagues, managers, vendors and many other people. Are you asking yourself why you aren't getting the opportunities you deserve? It's probably because you haven't made your intentions and capabilities clear to the decision makers in either speaking and/or writing. Being able to present a complex technology to people in other roles/verticals is a very important skill.
Curiosity – You have to be curious. You need to have an interest. Why did they design this technology this way? Is there a better way to do it? Isn't this technology very similar to this older technology? Being in IT means you need to stay updated and unless you are curious and enjoy working in the field, it will become a big chore to keep updated with the trends in networking. You will never reach your full potential unless you are curious and love to learn.
Analytical thinking – There are plenty of engineers that have decent technical skills. That can learn to implement something. Throw them a curveball though and they have no clue how to proceed. Analytical thinking is important in network design. What happens if this link goes away? What about if this router goes away? How large is the failure domain? Is there any fate sharing? I have a problem in a network with these symptoms, what could be causing it?
T-shaped skills – In order to be successful you need to have a broad skillset. You need to understand many different verticals, technologies and different businesses. However, you also need to be really good at something. In my case I'm really good at RS technologies and at network design. But I also need some understanding of security, wireless, storage, applications, operating systems and so on. The most important is to know what you know and to know what you don't know. If I don't know something I can find out through either asking someone more knowledgeable or by searching. The most dangerous situation is when a person thinks they know something but they really don't.
Some of you may agree with me and some not. The point of this post is to give people some insight in what it takes to be successful. Being proficient in Python or Ansible or the SDN solution du jour is not enough to have long term success. Technologies, tools and vendors may change over time but the skills above are timeless. So how does one get these skills? That is perhaps a topic for another post but the tl;dr is anyway you can.
I can Say, "MasT"(Gujarati) Superb!
Great blog post, thanks Daniel! Soft skills are so incredibly important and often overlooked.
Thanks, Simon! Indeed they are.
Can I propose an addition to your list?
"Personal Workflow and Information Management System".
Whether it's GTD, Seven Habits, etc, the point is to have a system for processing information. generating, prioritizing, and tasking tasks. filing information.
I see a lot of people who are self limited through lack of organization and ability to prioritize. Whenever I start to wander away from my system I notice a distinct dip in my productivity. When I commit to it every day, it's amazing what a difference it makes.
Thanks, Steven! Yeah, I haven't tried one of those yet, maybe I should give it a try.
This was a good read – I will however suggest one other skill that might be worth adding to the list and it does fall somewhat on the skill side of the fence. Know the fundamentals. I've seen a curious trend in networking over the last few years and I'm not 100% sure what's causing it but there seem to be more and more folks that are skipping the fundamentals. Maybe "skipping" isn't the right word, but they don't seem to have the basic underlying knowledge of how networks work. How data gets encapsulated in a frame – then a packet – etc, etc. And while I'm not advocating that a network engineer needs to know all of the possible headers in an Ethernet frame of IP packet, I do think that by not having any understanding of how it works you're missing critical information. For instance – if you don't know how framing works then you likely don't understand the consequences of changing an interfaces MTU.
I'll admit that this treads the line on "specializations" and I'm not suggesting that a network engineer needs to be an expert at "ALL THE THINGS" in order to proficient. But to me – without a working understanding of the fundamentals of networking – the higher level concepts and technologies mean very little. How can I understand if an overlay encapsulation like VXLAN is a good or bad thing if I don't understand it's impact on the frame? Specializations are great – but those need to be built on top of something. So if you're just learning how a specific piece of the technology works (cough, overlays, cough), but don't concern yourself with how they actually run on an existing network, you're setting yourself up for failure in my opinion.
You seemed to be hinting at this with some of your comments on skill set in the blog post, but its such an important item (at least to me) that I thought it worth calling out.
I've noticed the same trend which is why I'm trying to balance the view a bit. Podcasts like Packet Pushers etc do a great job of covering technology. However, for obvious reasons it's more interesting to cover new technologies rather than older ones. This leads to that for the people that perhaps have less experience than you and I that their world becomes very colored by podcasts, blogs etc. If prominent people are moving on towards newer technologies, why should I learn old technologies? This leads to putting too little time into the fundamentals and everytime something new comes out, it's like sipping from the fire hose again.
Russ, Ethan, Jordan did a great job with the network fundamentals book. Some people mistakenly assume fundamentals means beginner which is not the case. Like you said, all the new stuff like SDN, containers, cloud all run on TCP/IP and some form of Ethernet etc. If you've learned one overlay, it won't be difficult to learn the next. When your stuff breaks, and it will, then you need a little more understanding than just knowing it based on the abstractions.
It's definitely worth highlighting the fundamentals again and I've done this in other posts in the past. Thanks for reading!
Yes, for Manager in Network Engineering is a good advice and is true when they are hiring new employee. But for HRD, it is a different, the first things HRD see was certification and job experience. The first person employee meet is HRD. Only a little HRD understand what it truly needs to find good Network Engineer.
Så bra at du deler innsikten din med oss Daniel, ser bloggen din dukker opp oftere på diverse forum og medium, tyder på at du gjør gode ting for industrien. Stå på!!
Tack så mycket, Svein! Vill gärna hjälpa andra att göra det bästa av sina studier och karriärer. Tack för att du läser!


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Posted November 29th, 2021 by Jonathan Montagu,	in Drug discovery, From The Trenches, Science & Medicine
By Jonathan Montagu, CEO and Co-founder of HotSpot Therapeutics, as part of the From The Trenches feature of LifeSciVC
Today marks an important point in our journey to patients as HotSpot Therapeutics announces its $100MM Series C financing. This infusion of capital will enable HotSpot to transition into a clinical stage company while supporting further pipeline and platform growth. Our progress as a company tracks with the success of the entire field of allostery that has included Relay Therapeutics' demonstration of clinical proof of concept; the acquisition of Vividion Therapeutics by Bayer; and significant capital raises made by Exo Therapeutics, Scorpion Therapeutics and Frontier Medicines.
Systematic approaches to identifying and drugging allosteric sites are now within reach which is exciting for patients as historically intractable disease proteins yield to therapeutic intervention. In this blog, I wanted to reflect on some learnings from the past couple of years as we have built HotSpot from the ground up while pointing to new opportunities that are now ahead of us.
Pockets that matter
As readers will know, the dominant focus of small molecule drug discovery has historically been the substrate or active site, but such pockets can be inhospitable to drug candidates and selectivity can be hard to achieve. As drug hunters, we have strived to go beyond the active site, but unfortunately very few pockets on proteins are actually relevant to function.
How then can we find the pockets on proteins that matter? Typically this involves random screening. Traditional machine learning approaches do not help much here since there is a paucity of data to train models outside the active site. In-cell fragment screening and protein motion simulation can find pockets but there is no guarantee that these pockets are critical to protein function.
At HotSpot, we are solving this challenge through a sole focus on naturally-occuring pockets – called natural hotspots – that are decisive in the control of proteins in vivo. Natural hotspots encompass protein pockets and mechanisms used endogenously by the cell. This approach has allowed us to enrich for pockets, and in turn, small molecules that really matter to protein function. Moreover, since nature typically controls proteins with precision, natural hotspots tend to lead to highly selective modulators.
Using a suite of in-house developed artificial intelligence (AI) algorithms, we mine big and diverse datasets to build a picture of protein structure function that is solidly rooted in real-world evidence. Predictions are further amplified by looking across entire target classes. This has led to a new hotspot-focused taxonomy of proteins, where each category lends itself to a proprietary set of tools and chemistry that have been implemented inside HotSpot. Today, HotSpot has successfully progressed programs against all of these classes and is poised to select its first Development Candidates.
The Ghost in the Machine
Artificial Intelligence is a theme that has become ever more prominent in drug discovery but much of the excitement around small molecule AI relates to protein targets where there is a large body of existing evidence, for example, from previous big Pharma programs. Hotspot in contrast is uncovering new biological real estate and pairing this with novel chemotypes. Can AI really work at the frontiers of known biology and chemistry?
We are only just scratching the surface of what is possible but the answer is a clear 'yes'. Our most successful applications of AI to date are:
Relieving bottlenecks: through the algorithms described above we have identified about 1,500 targets with natural hotspot mechanisms. AI has been critical in helping us rapidly triage down to the cream of the crop targets that should enter our pipeline for wet lab prosecution. This ranges from natural hotspot prediction using algorithms that perform a type of facial recognition on 3D pockets, to feature detection amongst the screens of custom libraries directed at those pockets.
Increasing program probability of success: machine learning allows us to make sense of the 60 million or so hits that we get from each chemical library screen. These datasets provide a huge volume of structure-activity relationship (SAR) data that would take traditional chemistry campaigns a decade to generate. Relay Therapeutics' acquisition of ZebAI and our earlier acquisition of Macroceutics highlights the deep potential in this domain as the power of DNA-encoded libraries (DEL) meets structure-based drug discovery.
Patient selection: As we now venture into patients, we have the ability to leverage rich patient data to link our understanding of the biology of our targets to specific patient subsets.
To illustrate AI in action, the figure below shows how we use custom machine learning algorithms to predict common regulatory pockets within a transcription factor class and then both design and screen a chemical library directed at those pockets.
Moreover, we have learnt that organization and culture are just as important as the underlying technology. In executing against AI within HotSpot, our team brings deep drug discovery experience to the problem – similar to our peer group companies – constantly with an eye to designing molecules that are going to go the distance. However, the cross pollination of the drug hunter mindset with the disruptive, software engineering perspective is what we strive to achieve at HotSpot. With this in mind, we have sourced exclusive rights to enabling technology from players such as Macroceutics, Molecular Discovery and idalab.
Sustaining competitive advantage
Our industry becomes ever more competitive and the success of one mechanism rapidly leads to follow-on competition. K-Ras, SHP2, EGFR, and BTK are good examples and the list goes on. New companies e.g. EQRx, and business models have arisen purely to exploit the fast-follower model while contracting with payers.
In order to maintain our leadership position in allostery, companies like HotSpot cannot be complacent since our competitors will erode competitive advantage. We need to be continually challenging ourselves to deliver both first- and best-in-class small molecules. Thankfully allostery provides all the raw ingredients to deliver molecules with exquisite potency, selectivity and drug-like properties. This is especially true for natural hotspots because they represent a privileged subset of allosteric pockets.
Sanjiv Patel, CEO of Relay Therapeutics, has been particularly thoughtful on the topic of competitive advantage which, to paraphrase him, is driven by:
Riding the experience curve: delivering new allosteric medicines is technically very challenging and the industry leaders in allostery have successfully turned the crank multiple times. This leads to skill sets and scales of economy that can only be acquired over time, representing a large barrier to entry for new players.
Exploiting non-commoditized technology: the technology that we use to identify and drug natural hotspots is unique to HotSpot and cannot be accessed through outsourced service providers. For example, we have access to the largest and most diverse chemical library designed around natural hotspots that delivers 10x hit rates of conventional chemistries.
Leveraging a dominant position in a competitive labor market: as a company with a strong culture that is leading the way in natural allostery, we are able to disproportionately hire and retain the best talent in the most competitive labor ecosystems such as Boston and New Jersey. The creativity, drive and openness that our team brings to execution is a big differentiating factor.
To conclude, I am proud of what we have achieved over the past 36 months since it sets the stage for our first clinical trials and further growth of our pipeline and platform. However, I am also thrilled to be surrounded by such accomplished peer group companies that are also demonstrating the promise of allostery so convincingly. The next few years are going to be exciting as we deliver our allosteric medicines to patients.
Jonathan Montagu
CEO of HotSpot Therapeutics
View all posts by Jonathan Montagu →
This entry was posted in Drug discovery, From The Trenches, Science & Medicine and tagged allosteric inhibition, allostery, hotspot. Bookmark the permalink.

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Try, Try Again – Famous Faces Who Failed On Their Way To Success
Posted on Feb 27 2020 - 10:22am by Editorial Staff
Best For Business – How User-Generated Content Can Help You Corner The Social Media Market
7 Simple Tips for a Great At-Home Wedding
Even some of the most famous people in the world have experienced failure and rejection. Although we might celebrate their success today, many highly successful people have stumbled a few times on their way to the top. Here, Business Rescue Expert, who can advise on how to close a limited company, take a look at some of the most famous people who failed before they made it to superstardom.
It's quite difficult to comprehend that someone who has created an entire fantasy world based on creativity and imagination was fired from his first job for not thinking big enough. This was the case for Walt Disney though, a treasured figure in the cartoon animation industry, who lends his namesake to some of the most famous productions and a whole host of theme parks which celebrate and are inspired by his works. As a cartoonist, animator and film producer, he faced a string of rejections before his career took off. One of his earliest ventures 'Laugh-O-Grams' went bankrupt after a brief run of success, and this triggered his big move to Hollywood; where he went on to form the Disney that we know today with his brother Roy and a fellow cartoonist, Ub Iwerks. After his death in 1966, his legacy was propelled into the mainstream and it is constantly being adapted, evolving from his original ideas into epic productions on the silver screen. In 2018, the company was worth a staggering $98.6 billion, which shows how prolific his creations have become. From 'The Three Little Pigs' being rejected as it only had four characters, to Mickey Mouse being deemed ''too scary for women'', Walt Disney took many criticisms and progressed through them, creating a world of characters and stories which guided the childhood years of people all around the world.
The intensely crucial music mogul is notorious for his work in the entertainment industry, and in 2019 his net worth is near an eye-watering £436 million. His television phenomenon The X Factor first aired in 2004, and it was an immediate hit with viewers. However, his road to success was not without any struggles. In his education, his teachers deemed him a failure, with consistently low grades and a series of expulsions from numerous boarding schools. He began his working life as a clerk at EMI, a prolific record company, and he left at 23 to start his own recording venture; only for it to fold by the time he was 24. When he turned 30, he filed for bankruptcy, having lost all of his revenue he moved back in with his parents. His turning point unfolded during his time at BMG as a music consultant, where his pop acts made more than 25 million in album sales and had 17 UK singles. I t was onwards and upwards from then on for Cowell, and he still remains a force to be reckoned with in the entertainment industry.
Not all of us can boast a glowing record in our years of education – but neither can the notable American director, producer and screenwriter, Steven Spielberg. His career spans over four decades and he is considered as a pioneer of the New Hollywood Era, but things didn't just fall into place for him. After finishing high school with poor grades, Spielberg was rejected from the University of Southern California 3 times, but he did not simply accept this. By 1996, he was an honorary graduate and a trustee at USC, and by this time he had directed a long string of titles including Jaws (1975), E.T The Extra Terrestrial (1982) and The Colour Purple (1985). He is regarded by many as one of the most influential figures in the entertainment industry, winning 3 Academy Awards and 7 Emmy's. As of 2019, Spielberg's net worth was a staggering $3.7 billion, making him testament to the idea that your school grades really do not always follow you into professional life.
The words Richard Branson and failure don't seem to sit naturally together, considering he is one of the world's most infamous entrepreneurs. A school dropout, Branson has had some of the most notorious successes, alongside a string of failures. His first money spinning venture, Virgin Records, set a precedent and he has since branched out in to areas such as Virgin Galactic – a space-tourism initiative. The first actual business idea Branson had was Student, a generational magazine that attracted a string of big names but struggled to make serious profits. In 1984, Branson launched Virgin Atlantic Airlines, but it almost failed to take off at all, never mind become one of the biggest names in the aviation industry – due to a flock of stray birds flying into his test flight Boeing 747. Branson was constantly trying to break into unchartered territories, but his soda venture was a notable failure. Set to rival Coke and Pepsi, in 1994 he found that Virgin Cola just wasn't selling. However, he seems to have found the winning formula, with a current net worth of $4.1 billion.
While her talk show which began in 1986 is one of the highest–ranking television programs in American history, Oprah is hailed as 'The Queen of All Media' and rightly so. However, the road to success wasn't a simple journey, as the now billionaire screen queen and philanthropist found out. Her self–titled program is renowned for its empathy and compassion, and Oprah herself is praised for how attuned she is with her audience. Oprah's couch has become a point for people to confide and share thoughts and feelings, taking a personal setting and broadcasting it to millions of viewers eager to relate to her ability to create universal sentiments. She has tackled taboos at every end of the scale, giving a platform to those who bear the brunt of racism and tragedy. However, she was slated by producers in the past for these exact qualities, deciding that she was far too emotional to succeed in the industry. She has truly created her own self–help empire, and in 2013 she was awarded the Presidential Medal of Freedom – the nation's highest honour for civilians) by then president, Barack Obama.
That iconic Abbey Road shot may have just been an ordinary zebra crossing if The Beatles had listened to the first record label that they auditioned for. In fact, Decca Records could have changed the whole course of British music history, as they told George, John, Paul and Ringo that ''guitar music was on its way out'', concluding that their sound was unpolished and not current enough. Not many other bands would've had the sticking power after being knocked back by the leading record label of their time, but the foursome did not take it as the end. They were ahead of their time in terms of the music that they demonstrated to Decca, and while this didn't go in their favour, they soared to stardom and their first UK album topped the U.K charts for an astounding 30 weeks. In fact, The Beatles demonstrated the power of innovation by revising perceptions of rock music. So, the moral of the story here? Failure isn't definitive, and there is always room for revision to get where you want to be.
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Emerging theoretical approaches to complement single-particle cryo-electron microscopy
CECAM-IT-SISSA-SNS
The field of structural biology is experiencing a transformative phase thanks to remarkable advances in single-particle cryo-electron microscopy (cryo-EM). In recent years, the emergence of Direct Detection Devices (DDD) has driven a revolution in the field, enabling the determination of an increasing number of biomolecular systems with unprecedented details and resolution (Nogales Nat Methods 2016, 13). The explosion of deposited cryo-EM maps, which range from 5 Å to better than 2 Å resolution, is challenging computational biophysics to rapidly and robustly discern mechanistic implications from the experimental data. Emerging theoretical approaches aim at processing, validating, complementing, and interpreting cryo-EM data, overcoming issues in image analysis, map refinement, and in the simulation of large biomolecules.
For decades, computational biologists have been integral to the cryo-EM community by developing methods that generated interpretable atomic models from low-resolution maps. Initial rigid-body docking algorithms have been replaced by Monte Carlo (Di Maio et al. Nat Methods 2015, 12) and molecular dynamics (MD) fitting schemes. Pioneering packages such as Situs (Wriggers et al. J Struct Biol 1999, 125) and MD Flexible Fitting (Trabuco et al. Structure 2008, 16) use the gradient of the EM density as a penalty function for the potential, while other packages combine rigid-body fitting with a MD-driven refinement (Topf et al. Structure 2008, 16) or employ coarse-grained models to enable flexibility (de Vries & Zacharias Plos One 2012, 7). Today's cryo-EM maps often contain a range of resolutions, wherein structurally homogeneous regions are resolved to high resolution while conformationally variable regions are resolved to 6 Å or worse. Earlier methods were designed to refine into medium-resolution maps (~8 Å), leading to models of non-native conformations due to limitations of the algorithms. Enhanced sampling techniques during MD fitting reduce the likelihood of becoming trapped in local minima and more efficiently explore the conformational space presented by today's cryo-EM maps (Goh et al. Annu Rev Biophys 2016, 5).
Cryo-EM has the groundbreaking capacity to produce ensembles of coexisting conformational states enabling to elucidate molecular function. In pursuit of high-resolution structures, 2D and 3D classification is generally utilized to remove particle data exhibiting conformational heterogeneity, which questions how well atomic models represent not only the density from which they were generated, but the physiological architecture of the sample (Herzik et al. Structure 2019, 344). As such, theoretical approaches relying on Bayesian analysis are under development to deal with a large amount of data (Cossio et al. Comput Phys Commun 2017, 210), while image-processing software are being used to assess data classification (Kimanius et al. eLIFE 2016, 5). In parallel, MD is considered to explore the 3D conformational space, defining the most probable states to be interpolated with the 2D representations.
Finally, increasingly realistic biological systems challenge MD by requiring simulations of atomistic level biophysical events at longer time scales (He et al. Nature 2016, 533). In this respect, all-atom simulations including millions of explicit atoms demand next-generation algorithms and future exascale computing power, which will likely change the perspectives of computational biophysics.
Alessandra Magistrato ( CNR-IOM@SISSA ) - Organiser
Joanna Trylska ( University of Warsaw ) - Organiser
Michael Feig ( Michigan State University, East Lansing ) - Organiser
Gabriel Lander ( Scripps Research ) - Organiser
Giulia Palermo ( University of California Riverside ) - Organiser


Your worries about 70-465 exam completely no more exist, because GreatExam is here to serves as a guide to help you pass the exam. GreatExam offers the latest 70-465 PDF and VCE dumps with the new version VCE player for free download. All the 70-465 exam questions and answers are the latest and cover every aspect of 70-465 exam. It 100% ensures you pass the exam without any doubt.
You are the new database administrator for a SQL Server 2014 instance.
You conduct an assessment on the instance and determine that the auto create statistics setting on the database named DB1 has been turned off.
You see no evidence that any maintenance has been occurring.
You want to set up monitoring to see if query performance is being affected.
You need to set up a monitoring process that will capture any cases where statistics could have been useful if they existed.
A. Create a SQL Server Agent job to execute DBCC SHOWSTATISTICS on each of the primary key columns in the database.
B. Use the missing_column_statistics extended event.
C. Query the sys.statistics system view to see all cases where the statistics were last needed.
D. Write a query using the sys.dm_db_missing_index_group_stats DMV Joining to sys.indexes, filtering on is_hypothetical.
The Missing Column Statistics event class indicates that column statistics that could have been useful for the optimizer are not available.
By monitoring the Missing Column Statistics event class, you can determine if there are statistics missing for a column used by a query.
This can cause the optimizer to choose a less efficient query plan than expected.
You have two databases named DB1 and DB2 that are located on the same server.
An application role is a database principal that enables an application to run with its own, user-like permissions.
You can use application roles to enable access to specific data to only those users who connect through a particular application.
Unlike database roles, application roles contain no members and are inactive by default.
You have a server named Server1 that has 16 processors.
You plan to deploy multiple instances of SQL Server 2014 to Server1.
You need to recommend a method to allocate processors to each instance.
CPU affinity management through Windows System Resource Manager is not recommended for SQL Server multi-instance management. Instead, use the processor affinity settings in SQL Server.
You have two SQL Server 2014 instances named SQLDev and SQLProd.
You need to ensure that when the new database is copied from SQLProd to SQLDev, users can connect to the database on SQLDev even if they do not have a login on the SQLDev instance.
You have a query that is used by a reporting dashboard.
Users report that the query sometimes takes a long time to run.
You need to recommend a solution to identify what is causing the issue.
A. Set the blocked process threshold, and then run SQL Server Profiler.
B. Set the blocked process threshold, and then create an alert.
C. Enable trace flag 1204, and then create an alert.
D. Create a job that queries the sys.dm_os_waiting_tasks dynamic management view.
Step 1: Turn on the blocked process report.
This will look for any blocking taking 20 seconds or longer.
Step 2: Set up a trace to capture the blocked process report. Run it as a server side trace.
You need to identify the isolation level used by the query when a deadlock occurs.
D. Enable trace flag 1222, and then view the SQL Server error log.
Returns one row per authenticated session on SQL Server. sys.dm_exec_sessions is a server-scope view that shows information about all active user connections and internal tasks.
Transaction isolation level of the session.
You administer a SQL Server 2014 instance.
Users report that the SQL Server has seemed slow today.
A large database was being restored for much of the day, which could be causing issues.
– Whether the database restore is still executing and, if it is, what percentage of the restore is complete.
Which system objects should you use in your query to best achieve this task?
Returns information about each request that is executing within SQL Server.
This information includes client version, client program name, client login time, login user, current session setting, and more.
Returns the text of the SQL batch that is identified by the specified sql_handle.
Returns aggregate performance statistics for cached query plans in SQL Server.
The view contains one row per query statement within the cached plan, and the lifetime of the rows are tied to the plan itself.
Contains a row for each user-defined, schema-scoped object that is created within a database.
You have a database hosted on SQL Server 2012 R2.
The database contains 5 million rows.
You need to recommend a repeatable method to migrate the database to SQL Azure.
Which method should you recommend? More than one answer choice may achieve the goal. Select the BEST answer.
A. Create a SQL Server Integration Services (SSIS) package, and then run the package.
B. Back up the database, and then restore the database.
C. Extract a data-tier application, and then import the application.
the scripts by using SQL Azure.
– SSIS can be used to perform a broad range of data migration tasks.
SSIS provides support for complex workflow and data transformation between the source and destination. It is a good choice to transfer of data for databases that require many changes to work on Microsoft Azure SQL Database.
You can use SSIS data transfer packages with another mechanism for transferring the database schema, such as a Data-tier Application package.
Teams who have experience with the wizard.
Migrating simple databases that need few schema changes to run on Azure SQL Database.
The scripts generated from the source database can be modified before being used to create the new version of the database on Azure SQL Database, but using a database project in the SQL Server Data Tools has richer support for making schema changes.
Migrating small databases that do not have much data.
The wizard generates scripts that use insert statements instead of bulk copies to transfer the data. The insert statements can be throttled when the tables contain too much data, and are not as fast as bulk copies.
You have a SQL Server 2014 database named DB1.
You have a server named Server1 that has 2 processors.
Each instance will have multiple databases.
You need to recommend a method to allocate processor time to each database.
SQL Server Resource Governor is a feature than you can use to manage SQL Server workload and system resource consumption.
Resource Governor enables you to specify limits on the amount of CPU, physical IO, and memory that incoming application requests can use.
Enables hardware threads to be associated with CPUs.
You have a SQL Server 2014 environment That includes four servers.
– On Server1, enable SQL Server password policies and enable the default trace.
– On Server3, ensure that the names of user-defined stored procedures begin with the prefix "usp_" and ensure that all databases use a case-sensitive collation.
Need Standard or Enterprise edition of SQL Server.
You are the administrator for a SQL Server 2014 instance that stores the data for an online transaction processing sales system.
The company takes full backups every week; differential backups on the days with no full backups; and hourly transaction backups.
These backups are stored on a backup server in the company's data center.
Every week, the company places the full backup on a tape and sends it to a third-party backup storage system.
The company is worried that a disaster might occur that could destroy their computer center and cause them to lose orders.
You need to determine the best method for providing the smallest amount of data loss and downtime without leasing or purchasing additional physical locations.
A. Set up SQL Server Always On with a SQL Azure database as a replica.
B. Set up SQL Server Always On by using a SQL Server on a Windows Azure Virtual Machine.
C. Put the differential backup on tape and send it to the third-party backup storage system.
D. Use the Microsoft SQL Server Backup to Microsoft Windows Azure Tool to direct all backups to a different geographical location.
SQL Server 2012 was the first version to provide the ability to back up databases to the Cloud, and SQL Server 2014 improves on the process.
You need to recommend a backup process for data warehouse database.
– Ensure that if a hardware failure occurs, you can bring the database online without losing more than 24 hours of transactions.
– Minimize the amount of administrative effort required to restore any lost data.
– Minimize the space used by transaction logs.
What should you include in the recommendation? To answer, move the appropriate actions from the list of actions to the answer area and arrange them in the correct order.
Box 1: Set the database to the simple recovery model.
Box 2: Perform a weekly full backup of the database.
Box 3: Perform a differential backup of the database every night.
– Table2 will contain a column named Column2 which is the product of two other columns in Table2.
Both Table1 and Table2 will contain over one million rows.
The solution must minimize the time it takes to retrieve data from the tables.
– Sparse columns are ordinary columns that have an optimized storage for null values.
Sparse columns reduce the space requirements for null values at the cost of more overhead to retrieve nonnull values.
Consider using sparse columns when the space saved is at least 20 percent to 40 percent.
– A Persisted column would be faster to retrieve.
– A computed column is computed from an expression that can use other columns in the same table. The expression can be a noncomputed column name, constant, function, and any combination of these connected by one or more operators.
Unless otherwise specified, computed columns are virtual columns that are not physically stored in the table. Their values are recalculated every time they are referenced in a query.
The Database Engine uses the PERSISTED keyword in the CREATE TABLE and ALTER TABLE statements to physically store computed columns in the table.
Their values are updated when any columns that are part of their calculation change.
You use SQL Server 2014.
The system is expected to handle 50 million orders a month over the next five years.
You have been instructed by your Team Lead to follow best practices for storage and performance in the utilization of SPARSE columns.
Which columns should you designate as SPARSE? To answer, mark each column as SPARSE or NOT SPARSE in the answer area.
Sparse columns are ordinary columns that have an optimized storage for null values.
You need to create a single object that inserts a provided value into Table1, and then returns a count of the records in Table1.
Develop the solution by selecting and arranging the required code blocks in the correct order.
You may not need all of the code blocks.
You plan to install two SQL Server 2014 environments named Environment1 and Environment2.
– Environment1 must have mirroring with automatic failover implemented.
– Environment2 must have Always On with automatic failover implemented.
You need to identify the minimum number of SQL Server 2014 servers that must be deployed to each environment to ensure that all data remains available if a physical server fails.
How many servers should you identify? To answer, drag the appropriate number to the correct environment in the answer area.
You are the senior database administrator at Contoso, Ltd.
You manage a SQL Server 2014 Instance, with multiple databases used for reporting.
You have recently hired a junior database administrator.
You want this person to be able to view the database structures on the server, but you do not want him or her to be able to make changes or see the data in the tables.
You want the new hire to be required to change his password on his next login.
The code that is produced should execute no matter the initial database context in which it is started.
You need to write the code required to give the new hire only the desired access, using the smallest number of steps.
Applies to: SQL Server 2008 through SQL Server 2014.
Applies to SQL Server logins only. If this option is included, SQL Server prompts the user for a new password the first time the new login is used.
– The VIEW DEFINITION permission lets a user see the metadata of the securable on which the permission is granted. However, VIEW DEFINITION permission does not confer access to the securable itself. For example, a user that is granted only VIEW DEFINITION permission on a table can see metadata related to the table in the sys.objects catalog view. However, without additional permissions such as SELECT or CONTROL, the user cannot read data from the table.
– Environment1 must have mirroring with manual failover implemented.
– Environment2 must have AlwaysOn with automatic failover implemented.
You need to identify the minimum number of SQL Server 2012 servers that must be deployed to each environment to ensure that all data remains available if a physical server fails.
Fabrikam, Inc. is a retailer that sells electronics products on the Internet.
The company has a headquarters site and one satellite sales office.
You have been hired as the database administrator, and the company wants you to change the architecture of the Fabrikam ecommerce site to optimize performance and reduce downtime while keeping capital expenditures to a minimum.
To help with the solution, Fabrikam has decided to use cloud resources as well as on-premise servers.
All of the corporate executives, product managers, and support staff are stationed at the headquarters office.
Half of the sales force works at this location.
There is also a satellite sales office.
The other half of the sales force works at the satellite office in order to have sales people closer to clients in that area. Only sales people work at the satellite location.
To be successful, Fabrikam needs a website that is fast and has a high degree of system uptime. The current system operates on a single server and the company is not happy with the single point of failure this presents.
The current nightly backups have been failing due to insufficient space on the available drives and manual drive cleanup often needing to happen to get past the errors.
Additional space will not be made available for backups on the HQ or satellite servers. During your investigation, you discover that the sales force reports are causing significant contention.
The IT department has configured two physical servers with Microsoft Windows Server 2012 R2 and SQL Server 2014 Enterprise Edition and one Windows Azure Server.
There are two tiers of storage available for use by database files only a fast tier and a slower tier. Currently the data and log files are stored on the fast tier of storage only. If a possible use case exists, management would like to utilize the slower tier storage for data files.
The Product table is in the Production schema owned by the ProductionStaff Windows group.
It is the main table in the system so access to information in the Product table should be as fast as possible.
The SalesOrderDetail table holds the details about each sale.
It is in the Sales schema owned by the SalesStaff Windows group.
The current database does not perform well.
Additionally, a recent disk problem caused the system to go down, resulting in lost sales revenue. In reviewing the current system, you found that there are no automated maintenance procedures. The database is severely fragmented, and everyone has read and write access.
The database should be configured to maximize uptime and to ensure that very little data is lost in the event of a server failure.
To help with performance, the database needs to be modified so that it can support in-memory data, specifically for the Product table, which the CIO has indicated should be a memory-optimized table. The auto-update statistics option is set off on this database.
Only product managers are allowed to add products or to make changes to the name, description, price, cost, and supplier.
The changes are made in an internal database and pushed to the Product table in ProdDB during system maintenance time. Product managers and others working at the headquarters location also should be able to generate reports that include supplier and cost information.
Customers access the company's website to order products, so they must be able to read product information such asname, description, and price from the Product table.
When customers place orders, stored procedures calledby the website update product quantity-on-hand values. This means the product table is constantly updated at randomtimes.
Sales people at both the headquarters office and the satellite office must generate reports that read from the Product and SalesOrderDetail tables.
No updates or inserts are ever made by sales people.
These reports are run at random times and there can be no reporting downtime to refresh the data set except during the monthly maintenance window. The reports that run from the satellite office are process intensive queries with large data sets. Regardless of which office runs a sales force report, the SalesOrderDetail table should only return valid, committed order data; any orders not yet committed should be ignored.
The system should keep historical information about customers who access the site so that sales people can see how frequently customers log in and how long they stay on the site.
The information should be stored in a table called Customer Access.
Supporting this requirement should have minimal impact on production website performance.
– Revoked all existing read and write access to the database, leaving the schema ownership in place.
– Configured an Azure storage container secured with the storage account name MyStorageAccount with the primary access key StorageAccountKey on the cloud file server.
– SQL Server 2014 has been configured on the satellite server and is ready for use.
– On each database server, the fast storage has been assigned to drive letter F:, and the slow storage has been assigned to drive letter D:.
You need to distribute functionality across the three servers.
Which function should you assign to each server? To answer, drag the appropriate functions to the correct servers. Each function may be used once, more than once, or not at all. You may need to drag the split bar between panes or scroll to view content.
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BREAKING NEWS! Representative Toth Condemns Texas Lottery Commission for Targeting Low Income Dollar General Customers
By admin on November 22, 2019 No Comment
State Representative Steve Toth.
Austin, November 22 – Friday, Representative Steve Toth (R-Conroe) denounced the Texas Lottery Commissions' plans to offer lottery products in the checkout lines of fifteen hundred Dollar General stores across the state. At the Commission's most recent public meeting, Executive Director Gary Grief confirmed plans to go live with their in-line sales initiative at the discount retailer's Texas locations.
"Targeting the poor is shameful," said Rep. Toth. "The lottery was sold to Texans as the answer to funding Public Education but like most of the hundreds of dedicated funds three quarters of the funds go directly towards general revenue spending. Is the Commission pushing to sell lottery tickets in Macy's or Nordstrom? No, Dollar General. They are strategically marketing to the poor to obtain additional impulse purchases. You will never see a Dollar and a Dream advertised in a publication read by the middle or upper middle class, such as Forbes or the Wall Street Journal. Statistically, people with higher education and income are far less likely to buy tickets. They know they have a better chance of getting struck by lightening than winning the lottery. The Lottery Commission deliberately waited until the Legislature was out of session to make this deal because they knew we would fight them tooth and nail."
Steve Toth serves on the powerful House Appropriations Committee and is one of the strongest voices fighting for less government spending. He also serves on the Culture, Recreation & Tourism Committee, as well as multiple subcommittees.
Representative Toth is consistently ranked as one of the most conservative Republican legislators in the Capitol. Toth resides in Montgomery County with his wife Babette. He is a Realtor, small business owner, father of three, grandfather of two, an ordained minister and served as chairman of the board for Mighty Oaks.
Dollar General, Lottery, Poor, Toth
BREAKING NEWS! Representative Toth Condemns Texas Lottery Commission for Targeting Low Income Dollar General Customers added by admin on November 22, 2019


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Positions and papers
Patient Support & Resources
Patient Support Services
Crisis Pregnancy Support
Fetal Abnormality Diagnosis
Lethal Anomaly Diagnosis
Post-Abortive Support
Other Relevant Support Information
A to Z of New Zealand Pregnancy Resources
Financial Support for Pregnant Women or Parents
Rights to Healthcare – Pregnancy, Birth and Beyond
Abortion alternatives worksheet
Topical Issues and News
Abortion Law 'Reform': Twenty Questions that Deserve Answers
By NZHPA
Comments Off on Abortion Law 'Reform': Twenty Questions that Deserve Answers
Originally published on ABC, 12 May 2016.
By Rachael Wong
Independent MP Rob Pyne has introduced a private member's bill to amend Queensland's abortion laws, which may allow women to undergo abortions through all nine months of pregnancy – up until birth.
Pyne, who called the current law "archaic," has said that his bill does not give a time limit for abortion and that he would "compromise" with MPs as to when the "cut-off" should be.
This leaves open the possibility of an extreme abortion law, like in Victoria, Tasmania and ACT, all of which allow abortion up until birth.
But if the prospect of abortion up until birth isn't enough to make us reject Pyne's bill outright, there are still several questions we ought to be asking before we all jump on the bandwagon of "choice" and "progress":
1. How progressive are we really when we are willing to "compromise" the "cut-off" point for a human life?
2. At what point do we draw the line when a child's heart starts to beat at 5 weeks, it can feel pain by 20 weeks, and a week later can survive outside the womb?
3. How can we reconcile the lengths to which we will go to save a child born prematurely (cost, use of advanced medical technology and so on), with a law that could allow that same child to be aborted?
4. Are states like Victoria really the best model for abortion law reform? (There is currently a political push to introduce gestational limits in Victoria due to the excesses of its extreme abortion law.)
Pyne's bill would remove abortion from the criminal code, but leave in place section 313, which makes it a crime to cause the death of an unborn child in cases such as where a pregnant woman is assaulted.
5. Why the distinction between a child whose death is caused by someone assaulting its mother and one whose death is caused by abortion?
6. Does using a surgical or chemical process to cause death, rather than physical assault, really change what is happening to the child?
7. Why do we call it a tragedy when an unborn child dies from an assault or accident (including an accidental abortion), but not when it dies from an abortion?
8. Are these distinctions made because one child is wanted and the other is not? Is this really the best basis on which to create public policy?
9. Do the provisions criminalising abortion perhaps serve the same protective purpose for the child as section 313?
Pyne has said that the push for his bill was the case of a 12 year old girl from Queensland last month who needed permission from the Supreme Court to undergo an abortion.
10. Why the outcry over a 12 year old's inability to obtain an abortion, and barely a mention of why a 12 year old needed an abortion in the first place?
11. Are we not concerned about why and by whom 12 year olds – and apparently hundreds more 13 and 14 year olds – are getting pregnant?
12. Is abortion really going to solve these issues?
13. Or might it, at best, leave them unaddressed, or at worst, act as a shield for perpetrators of statutory rape?
14. Why do we persist in addressing symptoms instead of root causes to difficult or unplanned pregnancies?
15. Why are we not more concerned about our young girls being sexually active and exposing themselves to much worse than pregnancy (sexually transmitted infections, exploitation and so on)?
Deputy Premier of Queensland and Labor MP Jackie Trad, who is "unashamedly pro-choice," has publicly supported Pyne's bill stating that abortion is "a health issue, not a criminal issue" and that "what a woman decides to do with her body, in consultation with her doctor, does not belong in the criminal code."
16. If we are truly concerned about women's health, why the hush when it comes to the physical and psychological risks of abortion?
17. How does abortion promote women's health? What about the health of unborn women?
18. Are there not two human beings involved in every abortion? Does the current law not reflect this important reality?
19. Why do we perform highly advanced life-saving (and other) surgery on children in utero if a pregnancy only involves a woman and her doctor?
20. Is more abortion really the best we can offer women facing a difficult or unplanned pregnancy?
These are just some of the questions, among many, that need to be considered before forging ahead with a law that is supposedly about "women's health" and "choice" and "progress."
All this is not to say that women should be thrown in jail for undergoing abortions. Certainly not. There is no benefit in prosecuting women who are already vulnerable and suffering.
But I suspect that removing women's criminal liability isn't the real issue. Pyne's bill is about abortion on demand, for any reason, or for no reason.
Rachael Wong is a barrister from New Zealand. She is currently working with the Law Reform Commission in Samoa to bring about legislative reform to improve the lives of Samoan women and girls.
1899, abortion, abortion law, ACT, Australia, criminal, Criminal Code 1899, crisis pregnancy, decriminalisation, difficult pregnancy, doctor, ethical practice, extreme abortion law, foetal pain, foetus, gestational limits, Jackie Trad, late-term abortion, nurse, pregnancy, pregnancy options, premature, private member's bill, pro-choice, pro-life, Queensland, right to choose, Rob Pyne, suffering, Tasmania, The Abortion Law Reform (Woman's Right to Choose) Amendment Bill 2016, unborn child, unplanned pregnancy, Victoria, Victoria's Abortion Law 2008, woman, women
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PlayStation Network and Xbox Live Experiencing Connectivity Problems
By Eric Johnson@HeyHeyESJ Jul 17, 2014, 3:38pm EDT
Share All sharing options for: PlayStation Network and Xbox Live Experiencing Connectivity Problems
Owners of Sony and Microsoft's PlayStation and Xbox gaming consoles are reporting problems with connecting to their respective online services, the PlayStation Network and Xbox Live. At the time of this writing, Sony says its network is "intermittently available" due to high volume, which may be tied to the start of a beta period for the upcoming Bungie-Activision shooter Destiny. The beta doesn't start for a few more days on Xbox, however, and Microsoft says its video and music stores are also experiencing some connectivity problems.


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Features Rumors Streaming TV
Rumor: Dave Filoni Wrote Chapter 6 of The Book of Boba Fett
By Matt Heywood January 7, 2022
UPDATE – Both Dave Filoni and Jon Favreau wrote Episode 6, which is confirmed in the official fact sheet from Disney+.
According to The Direct, the new God of Star Wars, Dave Filoni, will be credited as the writer of The Book of Boba Fett's sixth episode. If you factor in that he has directed episodes of The Mandalorian that he has written, then fans should also expect him to be the director of the sixth episode as well.
The reason this matters is Filoni IS the person now who is in charge of Star Wars lore as a whole. While plenty of other artists contribute stories, Dave is the keeper of the lore and how it should be played out over the various properties telling canon-based Star Wars tales at this point. What this means is that he usually knows exactly the type of moments fans have been dying to see, and he also knows how to expertly stitch moments and characters from the past, present, and future together to make the Star Wars lore feel more coherent than ever before.
If this rumor pans out to be true, fans should expect for Episode 6 to be a doozy in terms of content. This could be the episode rumored characters from The Clone Wars or The Bad Batch could show up like Cad Bane or Omega. It could also just be an episode that dives into Boba's past in the OT and not flashbacks from his days on Tatooine learning from the Tuskens. Either way, if Filoni is the force behind S1E6, it's guaranteed to be a banger of an episode. We will soon find out this February!
Nick and I will talk more about Dave and Book in next week's episode of the SWTS, so don't forget to tune into the Star Wars Time Show on a weekly basis via our podcast platforms or via YouTube if you prefer the livestream angle.
Dave Filonithe book of boba fett
Temuera Morrison Teases The Book of Boba Fett Finale Will Have a "Wow" Moment
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Rumor: KOTOR to have different play modes


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Home Focus The Minister of Defence presents defence and security sector priorities of the...
The Minister of Defence presents defence and security sector priorities of the Slovenian Presidency of the Council of the EU
6. July, 2021
Minister of Defence Matej Tonin, NSi leader. (Photo: Nova24TV)
By: UKOM
At the webinar organized by the Egmont Royal Institute for International Relations in Belgium, Minister of Defence Matej Tonin, MSc, presented the priorities of the Slovenian Presidency of the EU Council in the defence and security sector.
The webinar was moderated by Dr Sven Biscop, expert in the field of the EU's Common Security and Defence Policy, and defence and security fields in general. The webinar was attended by broad interested professional and general public from Slovenia and EU institutions, and representatives of Member States, international organizations and third countries.
Minister of Defence Matej Tonin, MSc opened the webinar by saying that the main topics of the Slovenian Presidency of the Council of the EU in the defence and security sector very well reflect Slovenia's overall Presidency slogan – Together. Resilient. Europe. According to Minister Tonin, MSc, the priorities of the Slovenian Presidency are related to the strengthening of the EU's horizontal resilience, recovery and strategic autonomy, whereby he specifically emphasized the importance of cooperation and teamwork. He said that Slovenia was committed to green and digital transformation, and that, following the experience gained during the COVID-19 pandemic, it would devote attention to the promotion of cooperation and integration of lessons learned. Furthermore, it will continue its work related to the Conference on the Future of Europe, as well as the discussions on the European way of life and the rule of law.
With regard to the Common Security and Defence Policy, Minister Tonin, MSc, underlined that Slovenia would direct its efforts towards strengthening the EU's credibility and security, and building up the capabilities which the EU will use to achieve a more appropriate and determined response to crises through closer cooperation, while preserving values and freedoms, and respecting diversity. The priorities of Slovenian Presidency also derive from Slovenia's history and its geographical characteristics, said Minister Tonin, MSc, and highlighted the four key themes – EU-NATO partnership, Western Balkans, energy efficiency in the defence sector, and the continuation of the Strategic Compass process. In the field of the Civil Protection, the Slovenian Presidency will focus on the development of the Union's objectives for disaster resilience, and on the establishment and launching of the Union Civil Protection Knowledge Network.
lovenian Presidency of the EU Council
Minister of Defence Matej Tonin
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Hugh Bonneville Net Worth
How much is Hugh Bonneville worth?
November 10, 1963 (58 years old)
1.87 m, 6 ft 1 in
Hugh Bonneville Net Worth:
More about the earnings of Hugh Bonneville
Actor Hugh Bonneville has a networth that has to be considered pretty high.
It must be lovely to have such impressive net worth, Hugh Bonneville makes earning money look easy
Hugh Bonneville Net Worth: Hugh Bonneville is a British actor who has a net worth of $8 million. Hugh Bonneville was born in Blackheath, London, UK in November 1963. He is best known for playing Robert Crawley in the television series Downton Abbey. He graduated from Corpus Christi College and Webber Douglas Academy of Dramatic Art.
Inspirational Quotes by Hugh Bonneville
I love doing comedy.
I certainly couldn't run a big country house, nor could I organize the greatest show on earth.
Everyone at some point in their lives feels excluded and misunderstood.
I do realise how incredibly lucky I am.
I've had people come up to me in the past and say they enjoyed whatever show I've been in.
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Genesis Child Themes - Feast Design Co.
Foodie Pro is the number one selling Genesis child theme. Loved for it's simple, minimalist design that makes your content the star of the page, it's trusted by thousands of foodie and lifestyle bloggers around the world.
Years of fine-tuning and refining Foodie Pro has made it the most well-supported theme, and the feedback and lessons learned from our customers has led to the development of other child themes that incorporate these features.
The Genesis framework (by Studiopress) provides a basic set of best-practice settings and configurations for WordPress, helps bloggers stay on top of updates and changes without needing to be an expert, and allows for customization with child-themes.
You can find an overview document from Studiopress here.
What are "Parent" and "Child" Themes?
In a normal wordpress setup, there's simply a "theme" which contains both the stylistic and functional elements that make the blog look nice. WordPress is a multi-purpose platform however, being used not only for blogs but also membership sites, ecommerce stores, businesses and directories. This means that they need to be generic by necessity, which limits their usefulness.
Genesis is a "parent" theme.
Studiopress offers the Genesis theme, which comes with some customizations and functionality that make blogging easier and more straight-forward for the non-techy blogger. It makes WordPress more blogger-friendly. It's labeled as a "framework", as it provides a skeleton "framework" that designs can be built upon, which offering a consistent set of configurations that help manage the website and stay on top of changes in the code-base.
Designers and programmers that really understand the WordPress core and it's shortcoming gathered around this "framework" to build themes that are compatible with it, providing design and aesthetics. These adopted the name "child themes", language common to design, which indicates that their functionality is inherited (is preserved) from the "parent" – Genesis.
Our themes – Foodie Pro, Brunch Pro, Cook'd Pro, Cravings Pro, Seasoned Pro – are "child" themes, which stylize the Genesis framework and are specifically catered to help foodie bloggers make their recipes look better.
To you, this means that you need to spend less time with technical issues (thanks to Genesis), and don't need to be an expert designer (thanks to our expert designers) with our themes. You can jump right into running a blog that shares your unique recipes, personal style and attitude, and start earning revenue.


Celebrity photographer, John Stoddart – famed for his intimate portrait shots of the likes of Catherine Zeta-Jones, Liz Hurley and Tilda Swinton – is to release a rare collection of images to auction this week.
The British photographer, named as one of the 100 most influential photographers, by Professional Photographer, is renowned for capturing A-list celebs on the cusp of fame.
The stunning images taken by John Stoddart – whose works are owned by Martin Scorsese and Elizabeth Hurley – which are due to go on sale via online auction house catawiki.com, include a 22-year-old Catherine Zeta-Jones playfully cavorting on an unmade bed in the Dorchester Hotel, just before she left for Hollywood in 1991.
Among the stunning collection is another bedroom shot of Liz Hurley lounging in scanty lace underwear, as well as the wonderfully talented Oscar-winning Tilda Swinton photographed in 1986 posing barefoot on a pile of autumn leaves before her first film Carvaggio. There's also a close-up portrait shot of the gorgeous Daniel Craig, before he was even known as Bond, back in 2003.
Arnold Schwarzenegger, pictured at the Hotel Meurice in Paris in 1988.
It wasn't just movie stars either, there are rock n' roll legends galore amongst his finest accolades. A rare shot of rock legends The Rolling Stones, to include Keith Richards, Mick Jagger, Bill Wyman and Ronnie Wood snapped in 1988 is also set to go on sale, as well as a portrait shot of a shirtless Iggy Pop, photographed in 1999.
The images are expected to reach sale prices of up to £1,510, so if you're an avid art collector, this could be a worthwhile investment! And of course you'll have an original Stoddart taking pride of place on your wall. But if you can't part with that many pennies, just browse the collection here instead, they're pretty fabulous.
The auction will run from 4 March to the 11 March 2016 at auction.catawiki.com.
Have Rachel Weisz and Daniel Craig had their baby?


The exhausting weekends are over, so it's time for Project Gaia, again. Our fantasy world is growing and growing and growing and is becoming really scary complex, dood'!
Abe and I were busy with defining bullet points for the cultures of our 6 peoples. This definition includes the first 1000 years of the lygean calendar, and describes how far the different cultures have developed during that time.
That so far is done. I then used those bullet points, to order the most important historical events into a chronological timeline. Part of that was adding (admittedly arbitrary) dates.
How is their general physique?
What are their sexual characteristics?
How are they making and getting babies?
We collected many bullet points concerning these questions. My next task will be, to bring the physical and cultural bullet points in a textual structure, fit for presentation.
The greatest change of the last 2 days, was a new world map. The climatic situation of the old one made no sense at all, so we made a new map. We were very careful not to jeopardize the world history we've worked out so far, though.
Abe and I seem to bicker a lot lately. He holds the general view of us making a fantasy world. Which means, we don't need to pay too much attention to reality and logic. I on the other hand am a little bit more analytic with a focus on logic. Which brings me to often turn to reality.
In spite of it all, I have a growing feeling of getting to know our world (especially its people). Lygea is developing to a very believable, living world. All the work is worth it!


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Pep Guardiola Reveals What Will Happen If Man City Fail To Win Champions League
Pep Guardiola accepts his Manchester City tenure is likely to be judged on whether he succeeds in the Champions League or not. The City boss has set extraordinarily high standards for himself having previously guided Barcelona to victory in the competition twice. In comparison to that his spell in charge of Bayern Munich, where he
Pep Guardiola accepts his Manchester City tenure is likely to be judged on whether he succeeds in the Champions League or not.
The City boss has set extraordinarily high standards for himself having previously guided Barcelona to victory in the competition twice.
In comparison to that his spell in charge of Bayern Munich, where he was a three-time losing semi-finalist, is generally regarded as a disappointment, despite winning three Bundesliga titles and two German Cups.
Already at City, Guardiola has won the Premier League by a record margin and the League Cup twice, but he expects Europe to be the barometer of whether his reign is a success or failure.
He said: "I was judged in Munich in that way so I will be judged here as well. My period in Munich was not good for most people because we didn't get one final. We got semi-finals but we didn't get a final and we were judged.
"So, I'm a lucky guy. My standards are high. I have to reach it."
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COPENHAGEN FASHION SUMMIT
The Copenhagen Fashion Summit is the world's leading business event on sustainability in fashion. The event sees spokespeople from the industry come together for panel talks, interviews and discussions around moving towards a more sustainable future in fashion, covering environmental, social and ethical issues. I was invited to the sixth edition of the summit by ISKO, one of the event's sponsors, and Eco Age, a specialist sustainability and communications consultancy based in the UK and founded by sustainability queen Livia Firth.
On arrival at Copenhagen's magnificent Concert Hall, I was greeted by team ISKO. ISKO is the leading manufacturer behind some of the best-known denim brands. Sustainability in the denim industry is something ISKO is hugely passionate about, and as such, the brand has spent the last 20 years humbly developing a more ethical approach to its industry and being transparent across its entire supply chain. ISKO is the only denim mill in the world to have been awarded both the Nordic Swan Ecolabel and the EU Ecolabel for its Earth Fit collection. Both labels ensure the consumer knows they can trust what they are purchasing as brands certified need to meet a long list of criteria to meet the standards set.
As part of the event, I was attended many of the fascinating back-to-back talks scheduled throughout the day around sustainable brands and how some of the biggest brands in the world, including Nike and H&M, are taking steps (some of which are huge) to be more sustainable in their practices. This is such an important topic when we think about how many billions of products these brands are turning over annually.
Eric Sprunk, COO of Nike, led a talk entitled "To power and protect the future of sport," in which he revealed the steps the brand has committed to, one major development being Nike Grind. Nike Grind uses recycled athletic footwear and surplus manufacturing scraps to create performance products, ranging from new footwear and apparel to sports surfaces. To date, over 35,000 scrap shoes have been used for thousands of other applications. 75% of all Nike products now contain recycled scrap materials.
"We need to create simplified certification systems like 'organic' and 'fairtrade' messaging to ensure consumers can know and understand what they are purchasing."
Paul Dillinger, VP and Head of Global Product Innovation at Levi Strauss & Co, was incredibly engaging when discussing the realities of product manufacturing and how important to the Levi's brand it is. He questioned how, when 6 out of 10 samples end up in a landfill and Cape Town is running out of water, we can justify using 3,781 litres of water to make one pair of jeans. He also argued that in order to ensure a sustainable future in fashion we have to make it an expectation for every brand and every customer to live up to the standard rather than it being the exception.
British model Lily Cole, a longtime campaigner for sustainability, participated in a panel on "How do we talk about sustainability outside of this room?" She suggested that, as in the food industry, we need to create simplified certification systems like "organic" and "fairtrade" messaging to ensure consumers can know and understand what they are purchasing. Research Cole has conducted herself indicates that too much information can overwhelm people, and the more visually we can label products, the more consumers are likely to adopt ethical shopping habits.
Another sustainability hero in attendance was the incredible Stella McCartney, whose label has just released the world's first biodegradable trainer. Having always remained committed to sustainable fashion, McCartney revealed how as a designer, due to a limited but constantly evolving range of materials, she is sometimes forced to give up creative ideas and designs due to the lack of material available in an ethical form.
Though I was just a little over 24 hours in Copenhagen (my first trip), I left feeling inspired by the commitment at play in the fashion community, and proud of how the industry is progressing. Though there is still so much to do, and so many brands that need to change their ways, it feels like the change is (slowly but surely) coming and by both technological innovation and compassion for our planet and the people we share it with plus building an awareness around how we shop and wear our clothes we can once again make fashion feel great #FashionWith Feeling.
Jasmine Hemsley May 21, 2018 copenhagen, copenhagen fashion summit, eco, sustainable, sustainable fashion, eco-friendly, stella mccartney, isko, livia firth, nike, levi's, lily cole
HOLIDAY: LOOK 1
Jasmine Hemsley May 23, 2018 holiday, holiday fashion, sustainable, sus, summer, eco, eco-friendly, sustainable fashion, vintage, uzma bozai, ethical collection, the jacksons, guanabana, carla colour, antibad, salt-water sandals
WHAT I WORE IN AMSTERDAM
Jasmine Hemsley May 2, 2018 what i wore, amsterdam, travel, fashion, sustainable, sustainable fashion, eco, wool & the gang, paradise row, iden denim, iden, beyond skin, carla colour


Forty-one kindergarten students showcased their future careers at the 2018 promotional ceremony of the Alexander Henderson Elementary School, held at the Claude O. Markoe Elementary School auditorium on June 26.
Kindergarten students D'Shawn Alexander and Larissa Lamothe served as masters of ceremonies, welcoming their classmates, parents, teachers, faculty and staff to the program.
Principal Natasha O' Halloran-Smith gave opening remarks.
The two classes jointly recited "When I Grow Up," a poem that highlights the various career interests of the students.
"I could be a doctor to make everyone well. I could be a scientist to find a cure for diseases," the students declared.
Principal O'Halloran-Smith, Assistant Principal Loraine Cadet and Board of Education representative, Winona Hendricks presented students with certificates for successfully completing kindergarten. Ms. Camacho and Ms. Plaskett individually recognized students for their academic improvements, academic strengths and behavior.
Ms. Hendricks offered the young learners and their parents inspiring words.
Following the students' performance of their class song "Kinderfunk," Assistant Principal Cadet gave closing remarks.


Alloy includes an Editor stack, which allows you to manage your blog directly from your site -- create, modify, delete and backup your posts online!
This stack will allow you to create a backend for your blog. This secured backend allows you to create, modify and delete blog posts directly from your website without needing to use your FTP software to upload blog posts.
We offer a wide variety of tutorials for Alloy with topics ranging from the basics of getting started to more advanced topics like using the Alloy Conditionals stack.
This section, as well as the Password setup portion of the Editor's settings, are important in configuring your blog's backend. So much so that we've created a video below to get you started!
This is where you will configure the user name for your login.
This is where you will paste your hashed password, which you will receive when you're using the Setup Password feature. PLEASE watch through the video above to see how this process is done. This hashed password system provides a secure method of verifying your login, keeping your password from being published to the site.
Enabling this feature and then publishing your page will put the Alloy Editor into Password Setup mode. This allows you to created a secure hashed password. After creating your hashed password you will copy and paste it into the HASHED PASSWORD field above.
Once you've done so, disable this feature and once again republish your page. Your secure password has now been configured.
Please be sure to watch the Password Configuration video above.
Your user login screen features a logo above the User Name and Password fields. Normally it is the Alloy icon, but if you'd like you can enable this Custom Logo feature and provide your own logo. The logo must be no larger than 128 px tall. The Editor stack will scale down your image to be a max of 128 px tall. It is recommended to simply use a 128 px tall image though.
This field allows you to customize the placeholder text for the User Name field on the login screen.
This field allows you to customize the placeholder text for the Password field on the login screen.
You can insert your own custom text for the Login Button text label here.
Choose from one of Foundry's preset colors, or choose your own custom color, for the Login Button.
You can insert your own custom text for the Logout Button text label here.
Choose from one of Foundry's preset colors, or choose your own custom color, for the Logout Button.
Link to your blog page here. This will allow the Editor to know where your blog is located so that you can make use of the Editor's ability to view your posts right from the Posts List view.
Allows you to choose how many active blog posts will be shown on each of the Posts View pages.
Choose from several date configurations for how you wish the Posts List to display each post's date.
This is a purely aesthetic feature that will inverse the display of the Draft, Future and Active table headers.
Allows the rows within your Posts List view to highlight slightly when they are hovered over in the Posts List view.
Allows you to customize the labels for the Drafts, Future and Active posts lists for the Posts List view.
This label field allows you to customize the text for the Add New Post button.
Choose from one of Foundry's preset colors, or choose your own custom color, for the Add New Post Button.
The Editor stack has a simple spell checker for the text field where you write the main body of your blog posts. This option allows you to toggle that setting on or off.
The toolbar for the content field where you write the main body of your blog posts can be customized to have specific functionality enabled or disabled. There are five rows of toggle buttons in the settings for the stack that allow you to choose which features you wish to have toolbar buttons displayed for.
Allows you to hide the example Posts List view in edit mode.
Used for troubleshooting if bugs happen to crop up. This is only really useful for Elixir support. Otherwise you will want to leave this feature disabled.


The Walnut Grill is a fresh, casually unique dining experience fit for the entire family. We offer a diverse, Chef-driven menu in a very comfortable and inviting environment. We have six locations in Robinson Township, PA, Wexford, PA, Fox Chapel, PA, Bridgeville, PA, O'Fallon, MO and Ellisville, MO that offer a traditional dining room, a large comfortable bar with multiple flat screen TVs, private dining rooms, and large patios. We are open seven days a week for lunch and dinner and Sunday Buffet Brunch from 10:00 am–2:00 pm.