text:
Mercato, the Online Delivery Platform for Independent Grocers, Closes Funding Round Led by Greycroft
Company will use funds to expand its market base of over 750 independent grocers across the U.S., increase sales and marketing, and further develop analytics and services for grocery retailers
July 01, 2019 09:30 AM Eastern Daylight Time
SAN DIEGO--(BUSINESS WIRE)--Mercato, the online ordering and delivery platform for independent grocery stores, recently closed a funding round led by Greycroft, a leading venture capital firm focused on investments in the Internet and mobile markets, among others. The new funding will enable Mercato to execute on its strategy to expand into new markets from coast to coast and continue development of technology and services that enable independent grocers to compete online.
Among others participating in the funding round is previous investor Loeb Enterprises, managed by Michael Loeb, who was instrumental in the development and funding of Priceline.com.
Grocery e-commerce and delivery is becoming more and more in demand by consumers and Mercato is working to ensure independents can compete in this growing segment. In the U.S., the percentage of consumers who purchased groceries online this last year surged from about 23.1% to 36.8%, according to Coresight Research. Based on U.S. Census Bureau data, the 2019 percentage equates to about 93 million online grocery purchasers, a gain of nearly 35 million from last year. According to eMarketer's Grocery Ecommerce 2019 report, U.S. grocery e-commerce is estimated to be at $19.89 billion in 2019 to rank as the fastest-growing product category online.
What differentiates Mercato from other online grocery companies is that the platform was designed specifically to meet the unique e-commerce needs of independent grocery stores and specialty food retailers. "My family is in the grocery business and I grew up working in our family store. This experience highlighted to me the real disadvantage independents have when it comes to technology, innovation, and marketing. We want to level the playing field and allow these great local businesses to win against their competition, whoever it is," said Bobby Brannigan, tech entrepreneur and Mercato founder and CEO. "Mercato is the only platform that allows consumers to discover the best local grocers and specialty food retailers in their area. Besides all of the traditional pantry staples and packaged foods, customers get access to the freshest produce, fish, meat, ethnic and prepared foods, and can have them delivered to their home or business in about an hour."
Mercato enables merchants to throttle orders, define delivery lead times, communicate directly with their customers, and easily add items and change prices in real time on their Mercato storefront. Mercato also allows merchants to access product and pricing analytics to determine trends and manage inventory. Mercato handles the deliveries through its nationwide courier network and can often deliver up to 15 miles, or more.
"Mercato has been successful based on two important factors: its technology and its unique ability to serve the needs of independent grocers," said Ian Sigalow, co-founder of Greycroft. "We believe in the company's disciplined vision, strong management and vast market potential and look forward to working with them as the team continues to expand into new markets across the country."
About Greycroft
Greycroft is a leading venture capital firm focused on investments in the Internet and mobile markets. Greycroft leverages an extensive network of media and technology industry connections to help entrepreneurs gain visibility, build strategic relationships, bring their products to market, and build successful businesses. Greycroft manages in excess of $1 billion and has made over 200 investments since inception in leading companies including Acorns, Bird, Buddy Media, Huffington Post, Maker Studios, Thrive Market, Trunk Club, and Venmo. For more information, visit www.greycroft.com.
About Mercato
Mercato offers ecommerce and same-day delivery of high-quality groceries and specialty foods from more than 750 independently owned stores across the country. Bobby Brannigan, an entrepreneur who grew up working in his parent's grocery store in Brooklyn, NY, created Mercato to level the playing field by bringing online shopping and delivery to independent grocers and their valued customers. For more information, visit Mercato.com. Follow us on Facebook and Instagram.
Hilary McCarthy
Clearpoint Agency
hilary@clearpointagency.com
Mercato closed a funding round led by Greycroft, a leading venture capital firm focused on investments in the Internet & mobile markets, among others
#groceryshopping
#fooddelivery
#GroceryDelivery
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#funding
#grocer
#onlineshopping
#shoplocal
#supportlocal
#Mercato
#SanDiego
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Bobby Brannigan Mercato CEO & Co-Founder on LinkedIn
Mercato on Facebook
Mercato on Twitter
Mercato on LinkedIn
Mercato on Pinterest
Mercato on YouTube
Mercato on Instagram


text:
2018 - Mines Theses & Dissertations
Elevated temperature mechanical properties of line pipe steels
Jacobs_mines_0052E_11445.pdf
Jacobs, Taylor Roth
Matlock, David K.
dynamic strain aging
strain assisted tempering
X70 pipeline steel
The effects of deformation temperature near the dynamic strain aging (DSA) regime on the tensile properties of X70 and X52 line pipe steels were evaluated. Testing temperatures of interest were in the range of 25 to 350 °C, at engineering strain rates in the range of approximately 10 4 to 10 3 s 1. The X70 steel had a quasi-polygonal ferrite microstructure with austenite, martensite-austenite, and carbide microconstituents present. The X52 steel was a control material (anticipated to exhibit elevated temperature behaviors comparable to observations in the DSA literature) with a ferrite-pearlite microstructure. Elevated temperature tensile testing was used to strain material and measure the mechanical properties of the X52 and X70 steels. Further mechanical and microstructural characterization was performed on the as-received and deformed line pipe steels, or in situ during elevated temperature deformation. Digital image correlation (DIC) was used in situ to characterize localized deformation behaviors during testing of the line pipe steels. Strain rate jump tests (cycling of strain rates during deformation) were performed to measure the temperature dependence on the instantaneous strain rate sensitivities. Stress relaxation tests were used to measure the internal/effective stress components of the flow stress and apparent activation volumes. Torsional pendulum experiments were performed to measure internal friction carbon Snoek peak heights related to the free interstitial concentrations in bcc ferrite. Microstructural changes after tensile deformation were assessed at various length scales using scanning and transmission electron microscopy. Finally, high sensitivity phase analyses were performed using synchrotron wide-angle x-ray scattering. Both pipeline steels exhibited evidence of DSA under similar testing conditions. The DSA temperature regime for the X70 steel was slightly smaller than the DSA regime for the X52 steel. Manifestations of DSA during tensile testing (i.e. mechanical behavior within the DSA regime) include: serrated flow curves, stable localized deformation (in the form of propagating and nucleating deformation bands), increasing flow strength as a function of temperature, reduced ductility relative to room temperature, high strain hardening rates, high dislocation densities relative to room temperature, and negative strain rate sensitivities. There was a direct relationship between the flow curve morphologies and localized deformation band behaviors. Deformation band propagation was associated with relatively low frequency load drops in the flow curve and was typically observed at relatively low temperatures within the DSA regime. Deformation band nucleation was associated with relatively high serration frequencies and was typically observed at relatively high temperatures within the DSA regime. The critical strain required for serrated flow was greatest at the upper and lower boundaries for serrated flow. Negative strain rate sensitivities associated with samples tested within the DSA regime influenced necking behaviors in the pipeline steel tensile samples. Necking in samples that exhibited negative jump test strain rate sensitivity m-values was more concentrated (i.e. influenced a smaller portion of the gauge length) compared to samples with positive strain rate sensitivities. Necking initiated from previously propagating type deformation bands within the dynamic strain aging regime, and concentrated at a slightly higher rate than samples that exhibited uniform plastic deformation. At high temperatures outside the DSA regime, the X70 steel exhibited tensile behavior that deviated from the X52 that was a result of strain assisted tempering of the quasi-polygonal ferrite microstructure (referred to as strain assisted bainitic tempering, due to the similarities in phase changes present between the two microstructures during tempering). Evidence of tempering of the quasi-polygonal ferrite microstructure was the decomposition of austenite observed with wide-angle x-ray scattering and scanning electron microscopy and the dissolution of transition carbides. Precipitation of cementite, which is associated with low temperature tempering, was theorized to contribute to the relatively high temperature mechanical behavior. Strain assisted bainitic tempering caused a shift in the flow stress maximum to higher temperatures (i.e. precipitation strengthening caused an increase in the flow stress), reduced ductility, increased strain hardening rates, negative overall strain rate sensitivities, increased interstitial carbon concentrations in the ferrite, increased apparent activation volumes, and increased dislocation densities. Austenite decomposition (which was used as the primary indicator of tempering in the quasi-polygonal ferrite microstructure) was highly strain dependent at temperatures below approximately 300 °C. However, increased temperatures reduced the strain dependence on austenite decomposition (and tempering), therefore reducing the strain dependence on carbide precipitation and coarsening (i.e. tempering occurred during isothermal heating, prior to deformation). A theoretical X70 alloy (based on the steel used in the present study) was designed for optimized elevated temperature mechanical properties. It was theorized that maximum strengthening from strain assisted bainitic tempering could be achieved by retarding the coarsening of cementite precipitates in the quasi-polygonal ferrite grains. Additional carbide forming elements were added to the designed X70 alloy to retard cementite growth during tempering.

redpajama_set_name: RedPajamaCommonCrawl


Your crew is working on the 14th floor. They don't have time to come down for a delivery and they don't have to. Best Courier offers inside delivery. Unlike other delivery companies, our parcel couriers will take your freight or packages wherever you ask us to take it.
From small to large parcel delivery, we offer a full choice of delivery options to meet your requirements, including same day Parcel Delivery, Rush Delivery, Hot Shot Delivery and After Hours Delivery. Our Hot Shot Delivery means there are no other stops on the way - we go straight from origin to destination. Our After Hours Delivery Service means we can deliver your package any time of the day or night.
With inside delivery, neither you nor your staff have to drop what you're doing when the Best Courier delivery truck arrives; we gently handle your packages or freight for you.
Other No-Touch delivery companies are afraid to get their hands dirty. Our professional couriers and truck drivers are ready to handle any job, big or small.
When possible, we will take your pallets where they need to go. If not, our drivers will hand load the parcels onto two-wheel hand carts or four-wheel carts and deliver them to the appropriate location.
We have a full fleet of delivery vehicles, including cars, vans and dock-high straight-box trucks.
Our largest straight trucks can hold as many as 12 pallets.
Our commitment to on-time delivery has never wavered.
Our uniformed couriers prominently display their company ID Badge and are professional and courteous at all times.


text:
Historietes medievals (en castellano Historietas medievales) es una serie de televisión creada por Pot de plom y À Punt, la serie está dirigida por Xavi Castillo. Fue emitida una primera versión en 2002 por Canal Nou y en 2019 se grabó de nuevo con la colaboración de À punt media.

Argumento
Es una serie de humor creada por el Humorista Xavi Castillo sobre cuentos tradicionales valencianos.

Reparto

1ª temporada

 Xavi Castillo
 Juli Cantó
 Enric Juezas
 Héctor Juezas
 Rosanna Espinós
 Panxi Vivó
 Carles Esteve
 Pilar Almería
 Eduardo Zamanillo
 Iris Juezas
 Alba Blanco
 Conxi Domenech
 César Tormo

 Con la colaboración especial de
 Pep Gimeno

 Episodios
 Carmesina i els pirates Esclafamuntanyes Les fades i el vell El dimoni no fuma Les aventures de Xonan, el guerrer La caputxa negra Blai i el jutge d'Alcoi El visir envejós

 Les dues germanes i els trols

Véase también

 Autoindefinits
 Socarrats
 Maniatics
 Xavi Castillo

Enlaces externos
https://apuntmedia.es/va/la-colla/infantil/historietes-medievals

Referencias

Series de televisión de À Punt Mèdia
Series de televisión iniciadas en 2019

redpajama_set_name: RedPajamaWikipedia


text:
HomeAbout UsNews, company reports and blogBlogLife at REAPark it Forward: an REA hack with heart
Park it Forward: an REA hack with heart
Article by Richard Weissel
Published on 7th May 2018 — Read in 3 mins
One of the challenges of being a fast-growing digital business in Melbourne's inner suburb of Richmond is the lack of parking spaces. This is the story of how a group of us at REA hacked a solution for this lack, and raised money for charities in the process. This is the story of Park It Forward.
Back where it all began
The idea was kicked off at REAio (then known as Hack Day) in 2016 by one of our product managers. He had a car space in the building, and had seen that a lot of those were left empty each day.
We have a lot of people who drive to work and if they don't get early bird parking nearby, are stuck with moving their car every few hours. Why not fill those unused car spaces? The idea was realised. We wanted to match people with empty car spaces to those needing them.
The initial product we delivered was classic 'Hack Day'. The idea was floated a couple of weeks beforehand, so we had a few conversations, but we didn't really know where we'd get to until the end of the third day, at showcase.
Hack Day champions
Here came the really awesome bit. To create even more incentive for people to use Park It Forward, every time someone matched with an empty car park they could use, they were prompted to donate $10 to an REA Group charity.
It aligned beautifully with our REA Group values, in particular "Do it with Heart". It was such a win:win concept that people absolutely loved it. I'm delighted to say that we got a huge number of votes at showcase and were declared winners that Hack Day! Clearly people saw the value of the project as much as we did.
Some of Park It Forward's winning team at Hack Day
Even better, we were given permission to put it into practise and start using it for real in the REA Group carpark in Richmond, Melbourne.
What I've learnt
I've learnt a lot of tech of course, but I've also learnt a lot about different charities to which people donate. I've also met an enormous number of incredible and highly talented people through the project, from all across the business.
I think a big part of REAio is being able to work with people from across the business with different roles. In that first day, our team had a great mix of skills – product & sales (awesome for showcase), developers and systems engineers. That kind of spread over a high energy period like REAio gives you a real appreciation for other people's roles, one of the many things I learnt, and I'm still learning.
REA Group developer Richard Weissel manages Park It Forward in his spare time
Park it Forward today
Park it Forward has now been operating for 18 months and is still evolving. Today it is a simple Slackbot that everyone can access and simply request or release a carpark. Like a true REAio project, feedback is encouraged by the Park It Forward community and we make updates to the app when we can. The last release was automatic weekly updates on stats and daily reminders to people who've booked spots.
Park It Forward in action. The bot makes it easy for REA Group employees to find a car spot, book it and be prompted to donate to charity.
Last week's notification said we made $800 for charity (for just 1 week!). All together, and because REA Group match employee charity donations, the total is amazing. We've raised over $22,000 since the start of 2017! Our people absolutely love it and people in need benefit; that's why I keep doing it.
Richard Weissel
View profile for Richard Weissel
Saving 300k hours for teams with REA's design system
Category: Life at REA
Published on 23rd Jan 2023
Making Research Ops Visible
Published on 11th Jan 2023
Recapping Mental Health Month
Published on 14th Nov 2022
Refreshing our mental health first aid skills
Published on 13th Oct 2022
Alex Ryan's perspective on life and career changed when Audra arrived.
Published on 27th Sep 2022
REA Group's FY22 Sustainability Report and carbon footprint


Balkan action/2015 Youth Academy is a training and networking event for 30 young people in the Balkans. If you are considering yourself a young leader, influential social media activist and young journalist from the participating countries you are kindly invited to be part of this special opportunity in the youth action/2015 SDGs training academy.
The role of the academy is to build capacities on SDGs, to motivate and engage the young multipliers from Balkans in the action/2015 and the further mobilisation of the communities in SDGs and related processes such as COP21. In addition, during the Academy, the mobilization strategy, both for the national and regional level, for the International Youth Day and United Nations General Assembly will be developed, as well as the Draft on the Action/2015 Western Balkans Youth Declaration on SDGs, including advocacy strategy for adoption of the Declaration by the National Youth Councils in the region.
The Balkan action/2015 Youth Academy is organised by the Centre for Human Rights and Development Studies (CHRDS), Center for Intercultural Dialogues and Beyond Barriers, and it is a part of the action/2015 campaign http://www.action2015.org.
To apply fill the form by 17 July. All successful applicants will be notified by 20 July 2015.
The Balkan action/2015 Youth Academy will be held in Struga, Macedonia from 1-4 August 2015.
CRCD Information campaign "1 Euroregion x week"
Donate for the Skopje flood victims!


text:
package IO::Handle;

=head1 NAME

IO::Handle - supply object methods for I/O handles

=head1 SYNOPSIS

    use IO::Handle;

    $io = IO::Handle->new();
    if ($io->fdopen(fileno(STDIN),"r")) {
        print $io->getline;
        $io->close;
    }

    $io = IO::Handle->new();
    if ($io->fdopen(fileno(STDOUT),"w")) {
        $io->print("Some text\n");
    }

    # setvbuf is not available by default on Perls 5.8.0 and later.
    use IO::Handle '_IOLBF';
    $io->setvbuf($buffer_var, _IOLBF, 1024);

    undef $io;       # automatically closes the file if it's open

    autoflush STDOUT 1;

=head1 DESCRIPTION

C<IO::Handle> is the base class for all other IO handle classes. It is
not intended that objects of C<IO::Handle> would be created directly,
but instead C<IO::Handle> is inherited from by several other classes
in the IO hierarchy.

If you are reading this documentation, looking for a replacement for
the C<FileHandle> package, then I suggest you read the documentation
for C<IO::File> too.

=head1 CONSTRUCTOR

=over 4

=item new ()

Creates a new C<IO::Handle> object.

=item new_from_fd ( FD, MODE )

Creates an C<IO::Handle> like C<new> does.
It requires two parameters, which are passed to the method C<fdopen>;
if the fdopen fails, the object is destroyed. Otherwise, it is returned
to the caller.

=back

=head1 METHODS

See L<perlfunc> for complete descriptions of each of the following
supported C<IO::Handle> methods, which are just front ends for the
corresponding built-in functions:

    $io->close
    $io->eof
    $io->fcntl( FUNCTION, SCALAR )
    $io->fileno
    $io->format_write( [FORMAT_NAME] )
    $io->getc
    $io->ioctl( FUNCTION, SCALAR )
    $io->read ( BUF, LEN, [OFFSET] )
    $io->print ( ARGS )
    $io->printf ( FMT, [ARGS] )
    $io->say ( ARGS )
    $io->stat
    $io->sysread ( BUF, LEN, [OFFSET] )
    $io->syswrite ( BUF, [LEN, [OFFSET]] )
    $io->truncate ( LEN )

See L<perlvar> for complete descriptions of each of the following
supported C<IO::Handle> methods.  All of them return the previous
value of the attribute and takes an optional single argument that when
given will set the value.  If no argument is given the previous value
is unchanged (except for $io->autoflush will actually turn ON
autoflush by default).

    $io->autoflush ( [BOOL] )                         $|
    $io->format_page_number( [NUM] )                  $%
    $io->format_lines_per_page( [NUM] )               $=
    $io->format_lines_left( [NUM] )                   $-
    $io->format_name( [STR] )                         $~
    $io->format_top_name( [STR] )                     $^
    $io->input_line_number( [NUM])                    $.

The following methods are not supported on a per-filehandle basis.

    IO::Handle->format_line_break_characters( [STR] ) $:
    IO::Handle->format_formfeed( [STR])               $^L
    IO::Handle->output_field_separator( [STR] )       $,
    IO::Handle->output_record_separator( [STR] )      $\

    IO::Handle->input_record_separator( [STR] )       $/

Furthermore, for doing normal I/O you might need these:

=over 4

=item $io->fdopen ( FD, MODE )

C<fdopen> is like an ordinary C<open> except that its first parameter
is not a filename but rather a file handle name, an IO::Handle object,
or a file descriptor number.  (For the documentation of the C<open>
method, see L<IO::File>.)

=item $io->opened

Returns true if the object is currently a valid file descriptor, false
otherwise.

=item $io->getline

This works like <$io> described in L<perlop/"I/O Operators">
except that it's more readable and can be safely called in a
list context but still returns just one line.  If used as the conditional
+within a C<while> or C-style C<for> loop, however, you will need to
+emulate the functionality of <$io> with C<< defined($_ = $io->getline) >>.

=item $io->getlines

This works like <$io> when called in a list context to read all
the remaining lines in a file, except that it's more readable.
It will also croak() if accidentally called in a scalar context.

=item $io->ungetc ( ORD )

Pushes a character with the given ordinal value back onto the given
handle's input stream.  Only one character of pushback per handle is
guaranteed.

=item $io->write ( BUF, LEN [, OFFSET ] )

This C<write> is somewhat like C<write> found in C, in that it is the
opposite of read. The wrapper for the perl C<write> function is
called C<format_write>. However, whilst the C C<write> function returns
the number of bytes written, this C<write> function simply returns true
if successful (like C<print>). A more C-like C<write> is C<syswrite>
(see above).

=item $io->error

Returns a true value if the given handle has experienced any errors
since it was opened or since the last call to C<clearerr>, or if the
handle is invalid. It only returns false for a valid handle with no
outstanding errors.

=item $io->clearerr

Clear the given handle's error indicator. Returns -1 if the handle is
invalid, 0 otherwise.

=item $io->sync

C<sync> synchronizes a file's in-memory state  with  that  on the
physical medium. C<sync> does not operate at the perlio api level, but
operates on the file descriptor (similar to sysread, sysseek and
systell). This means that any data held at the perlio api level will not
be synchronized. To synchronize data that is buffered at the perlio api
level you must use the flush method. C<sync> is not implemented on all
platforms. Returns "0 but true" on success, C<undef> on error, C<undef>
for an invalid handle. See L<fsync(3c)>.

=item $io->flush

C<flush> causes perl to flush any buffered data at the perlio api level.
Any unread data in the buffer will be discarded, and any unwritten data
will be written to the underlying file descriptor. Returns "0 but true"
on success, C<undef> on error.

=item $io->printflush ( ARGS )

Turns on autoflush, print ARGS and then restores the autoflush status of the
C<IO::Handle> object. Returns the return value from print.

=item $io->blocking ( [ BOOL ] )

If called with an argument C<blocking> will turn on non-blocking IO if
C<BOOL> is false, and turn it off if C<BOOL> is true.

C<blocking> will return the value of the previous setting, or the
current setting if C<BOOL> is not given.

If an error occurs C<blocking> will return undef and C<$!> will be set.

=back

If the C functions setbuf() and/or setvbuf() are available, then
C<IO::Handle::setbuf> and C<IO::Handle::setvbuf> set the buffering
policy for an IO::Handle.  The calling sequences for the Perl functions
are the same as their C counterparts--including the constants C<_IOFBF>,
C<_IOLBF>, and C<_IONBF> for setvbuf()--except that the buffer parameter
specifies a scalar variable to use as a buffer. You should only
change the buffer before any I/O, or immediately after calling flush.

WARNING: The IO::Handle::setvbuf() is not available by default on
Perls 5.8.0 and later because setvbuf() is rather specific to using
the stdio library, while Perl prefers the new perlio subsystem instead.

WARNING: A variable used as a buffer by C<setbuf> or C<setvbuf> B<must not
be modified> in any way until the IO::Handle is closed or C<setbuf> or
C<setvbuf> is called again, or memory corruption may result! Remember that
the order of global destruction is undefined, so even if your buffer
variable remains in scope until program termination, it may be undefined
before the file IO::Handle is closed. Note that you need to import the
constants C<_IOFBF>, C<_IOLBF>, and C<_IONBF> explicitly. Like C, setbuf
returns nothing. setvbuf returns "0 but true", on success, C<undef> on
failure.

Lastly, there is a special method for working under B<-T> and setuid/gid
scripts:

=over 4

=item $io->untaint

Marks the object as taint-clean, and as such data read from it will also
be considered taint-clean. Note that this is a very trusting action to
take, and appropriate consideration for the data source and potential
vulnerability should be kept in mind. Returns 0 on success, -1 if setting
the taint-clean flag failed. (eg invalid handle)

=back

=head1 NOTE

An C<IO::Handle> object is a reference to a symbol/GLOB reference (see
the C<Symbol> package).  Some modules that
inherit from C<IO::Handle> may want to keep object related variables
in the hash table part of the GLOB. In an attempt to prevent modules
trampling on each other I propose the that any such module should prefix
its variables with its own name separated by _'s. For example the IO::Socket
module keeps a C<timeout> variable in 'io_socket_timeout'.

=head1 SEE ALSO

L<perlfunc>,
L<perlop/"I/O Operators">,
L<IO::File>

=head1 BUGS

Due to backwards compatibility, all filehandles resemble objects
of class C<IO::Handle>, or actually classes derived from that class.
They actually aren't.  Which means you can't derive your own
class from C<IO::Handle> and inherit those methods.

=head1 HISTORY

Derived from FileHandle.pm by Graham Barr E<lt>F<gbarr@pobox.com>E<gt>

=cut

use 5.006_001;
use strict;
our($VERSION, @EXPORT_OK, @ISA);
use Carp;
use Symbol;
use SelectSaver;
use IO ();	# Load the XS module

require Exporter;
@ISA = qw(Exporter);

$VERSION = "1.35";
$VERSION = eval $VERSION;

@EXPORT_OK = qw(
    autoflush
    output_field_separator
    output_record_separator
    input_record_separator
    input_line_number
    format_page_number
    format_lines_per_page
    format_lines_left
    format_name
    format_top_name
    format_line_break_characters
    format_formfeed
    format_write

    print
    printf
    say
    getline
    getlines

    printflush
    flush

    SEEK_SET
    SEEK_CUR
    SEEK_END
    _IOFBF
    _IOLBF
    _IONBF
);

################################################
## Constructors, destructors.
##

sub new {
    my $class = ref($_[0]) || $_[0] || "IO::Handle";
    if (@_ != 1) {
	# Since perl will automatically require IO::File if needed, but
	# also initialises IO::File's @ISA as part of the core we must
	# ensure IO::File is loaded if IO::Handle is. This avoids effect-
	# ively "half-loading" IO::File.
	if ($] > 5.013 && $class eq 'IO::File' && !$INC{"IO/File.pm"}) {
	    require IO::File;
	    shift;
	    return IO::File::->new(@_);
	}
	croak "usage: $class->new()";
    }
    my $io = gensym;
    bless $io, $class;
}

sub new_from_fd {
    my $class = ref($_[0]) || $_[0] || "IO::Handle";
    @_ == 3 or croak "usage: $class->new_from_fd(FD, MODE)";
    my $io = gensym;
    shift;
    IO::Handle::fdopen($io, @_)
	or return undef;
    bless $io, $class;
}

#
# There is no need for DESTROY to do anything, because when the
# last reference to an IO object is gone, Perl automatically
# closes its associated files (if any).  However, to avoid any
# attempts to autoload DESTROY, we here define it to do nothing.
#
sub DESTROY {}

################################################
## Open and close.
##

sub _open_mode_string {
    my ($mode) = @_;
    $mode =~ /^\+?(<|>>?)$/
      or $mode =~ s/^r(\+?)$/$1</
      or $mode =~ s/^w(\+?)$/$1>/
      or $mode =~ s/^a(\+?)$/$1>>/
      or croak "IO::Handle: bad open mode: $mode";
    $mode;
}

sub fdopen {
    @_ == 3 or croak 'usage: $io->fdopen(FD, MODE)';
    my ($io, $fd, $mode) = @_;
    local(*GLOB);

    if (ref($fd) && "".$fd =~ /GLOB\(/o) {
	# It's a glob reference; Alias it as we cannot get name of anon GLOBs
	my $n = qualify(*GLOB);
	*GLOB = *{*$fd};
	$fd =  $n;
    } elsif ($fd =~ m#^\d+$#) {
	# It's an FD number; prefix with "=".
	$fd = "=$fd";
    }

    open($io, _open_mode_string($mode) . '&' . $fd)
	? $io : undef;
}

sub close {
    @_ == 1 or croak 'usage: $io->close()';
    my($io) = @_;

    close($io);
}

################################################
## Normal I/O functions.
##

# flock
# select

sub opened {
    @_ == 1 or croak 'usage: $io->opened()';
    defined fileno($_[0]);
}

sub fileno {
    @_ == 1 or croak 'usage: $io->fileno()';
    fileno($_[0]);
}

sub getc {
    @_ == 1 or croak 'usage: $io->getc()';
    getc($_[0]);
}

sub eof {
    @_ == 1 or croak 'usage: $io->eof()';
    eof($_[0]);
}

sub print {
    @_ or croak 'usage: $io->print(ARGS)';
    my $this = shift;
    print $this @_;
}

sub printf {
    @_ >= 2 or croak 'usage: $io->printf(FMT,[ARGS])';
    my $this = shift;
    printf $this @_;
}

sub say {
    @_ or croak 'usage: $io->say(ARGS)';
    my $this = shift;
    local $\ = "\n";
    print $this @_;
}

# Special XS wrapper to make them inherit lexical hints from the caller.
_create_getline_subs( <<'END' ) or die $@;
sub getline {
    @_ == 1 or croak 'usage: $io->getline()';
    my $this = shift;
    return scalar <$this>;
}

sub getlines {
    @_ == 1 or croak 'usage: $io->getlines()';
    wantarray or
	croak 'Can\'t call $io->getlines in a scalar context, use $io->getline';
    my $this = shift;
    return <$this>;
}
1; # return true for error checking
END

*gets = \&getline;  # deprecated

sub truncate {
    @_ == 2 or croak 'usage: $io->truncate(LEN)';
    truncate($_[0], $_[1]);
}

sub read {
    @_ == 3 || @_ == 4 or croak 'usage: $io->read(BUF, LEN [, OFFSET])';
    read($_[0], $_[1], $_[2], $_[3] || 0);
}

sub sysread {
    @_ == 3 || @_ == 4 or croak 'usage: $io->sysread(BUF, LEN [, OFFSET])';
    sysread($_[0], $_[1], $_[2], $_[3] || 0);
}

sub write {
    @_ >= 2 && @_ <= 4 or croak 'usage: $io->write(BUF [, LEN [, OFFSET]])';
    local($\) = "";
    $_[2] = length($_[1]) unless defined $_[2];
    print { $_[0] } substr($_[1], $_[3] || 0, $_[2]);
}

sub syswrite {
    @_ >= 2 && @_ <= 4 or croak 'usage: $io->syswrite(BUF [, LEN [, OFFSET]])';
    if (defined($_[2])) {
	syswrite($_[0], $_[1], $_[2], $_[3] || 0);
    } else {
	syswrite($_[0], $_[1]);
    }
}

sub stat {
    @_ == 1 or croak 'usage: $io->stat()';
    stat($_[0]);
}

################################################
## State modification functions.
##

sub autoflush {
    my $old = new SelectSaver qualify($_[0], caller);
    my $prev = $|;
    $| = @_ > 1 ? $_[1] : 1;
    $prev;
}

sub output_field_separator {
    carp "output_field_separator is not supported on a per-handle basis"
	if ref($_[0]);
    my $prev = $,;
    $, = $_[1] if @_ > 1;
    $prev;
}

sub output_record_separator {
    carp "output_record_separator is not supported on a per-handle basis"
	if ref($_[0]);
    my $prev = $\;
    $\ = $_[1] if @_ > 1;
    $prev;
}

sub input_record_separator {
    carp "input_record_separator is not supported on a per-handle basis"
	if ref($_[0]);
    my $prev = $/;
    $/ = $_[1] if @_ > 1;
    $prev;
}

sub input_line_number {
    local $.;
    () = tell qualify($_[0], caller) if ref($_[0]);
    my $prev = $.;
    $. = $_[1] if @_ > 1;
    $prev;
}

sub format_page_number {
    my $old;
    $old = new SelectSaver qualify($_[0], caller) if ref($_[0]);
    my $prev = $%;
    $% = $_[1] if @_ > 1;
    $prev;
}

sub format_lines_per_page {
    my $old;
    $old = new SelectSaver qualify($_[0], caller) if ref($_[0]);
    my $prev = $=;
    $= = $_[1] if @_ > 1;
    $prev;
}

sub format_lines_left {
    my $old;
    $old = new SelectSaver qualify($_[0], caller) if ref($_[0]);
    my $prev = $-;
    $- = $_[1] if @_ > 1;
    $prev;
}

sub format_name {
    my $old;
    $old = new SelectSaver qualify($_[0], caller) if ref($_[0]);
    my $prev = $~;
    $~ = qualify($_[1], caller) if @_ > 1;
    $prev;
}

sub format_top_name {
    my $old;
    $old = new SelectSaver qualify($_[0], caller) if ref($_[0]);
    my $prev = $^;
    $^ = qualify($_[1], caller) if @_ > 1;
    $prev;
}

sub format_line_break_characters {
    carp "format_line_break_characters is not supported on a per-handle basis"
	if ref($_[0]);
    my $prev = $:;
    $: = $_[1] if @_ > 1;
    $prev;
}

sub format_formfeed {
    carp "format_formfeed is not supported on a per-handle basis"
	if ref($_[0]);
    my $prev = $^L;
    $^L = $_[1] if @_ > 1;
    $prev;
}

sub formline {
    my $io = shift;
    my $picture = shift;
    local($^A) = $^A;
    local($\) = "";
    formline($picture, @_);
    print $io $^A;
}

sub format_write {
    @_ < 3 || croak 'usage: $io->write( [FORMAT_NAME] )';
    if (@_ == 2) {
	my ($io, $fmt) = @_;
	my $oldfmt = $io->format_name(qualify($fmt,caller));
	CORE::write($io);
	$io->format_name($oldfmt);
    } else {
	CORE::write($_[0]);
    }
}

sub fcntl {
    @_ == 3 || croak 'usage: $io->fcntl( OP, VALUE );';
    my ($io, $op) = @_;
    return fcntl($io, $op, $_[2]);
}

sub ioctl {
    @_ == 3 || croak 'usage: $io->ioctl( OP, VALUE );';
    my ($io, $op) = @_;
    return ioctl($io, $op, $_[2]);
}

# this sub is for compatibility with older releases of IO that used
# a sub called constant to determine if a constant existed -- GMB
#
# The SEEK_* and _IO?BF constants were the only constants at that time
# any new code should just check defined(&CONSTANT_NAME)

sub constant {
    no strict 'refs';
    my $name = shift;
    (($name =~ /^(SEEK_(SET|CUR|END)|_IO[FLN]BF)$/) && defined &{$name})
	? &{$name}() : undef;
}

# so that flush.pl can be deprecated

sub printflush {
    my $io = shift;
    my $old;
    $old = new SelectSaver qualify($io, caller) if ref($io);
    local $| = 1;
    if(ref($io)) {
        print $io @_;
    }
    else {
	print @_;
    }
}

1;

redpajama_set_name: RedPajamaGithub


text:
LGBT leader calls New York same-sex marriage bill "game changer"
June 28, 2011		 | By Lorna Aldrich | lorna2@verizon.net
Rea Carey, executive director of the Gay and Lesbian Task Force, called the New York state legilature's passage of a same-sex marriage bill, "a major turning point in progress toward marriage equality, a game changer" at a June 28 Newsmaker.
Carey, who leads the oldest organization supporting Lesbian, Gay, Bisexual and Transgender (LGBT) rights, said the bill doubles the population eligible for same-sex marriage.
"What a difference 42 years makes," she said. In 1969, when homosexual acts were illegal, mass arrests of LGBT people at the Stonewall Inn in New York City led to six days of riots.
The last four decades have been a story of progress, but it hasn't happened overnight according to Carey, and there is more progress to be made.
"There are  damaging and dangerous gaps in protection of LGBT people now," she said.
The Task Force addresses "bread and butter" issues that affect people's lives, she said. Only 14 states and the District of Columbia offer LGBT people protection against discrimination in employment and housing.
She cited signs of progress. Unions and corporations have adopted policies protecting LGBT people, which is "huge," Carey said. President Barack Obama has determined not to defend the Defense of Marriage Act in courts, another positive development. The 2010 Census counted married same-sex couples so their children were not listed as living with a single parent.
"The health care reform bill will actually benefit more LGBT people than any other legislation that we are working on," she said. Hospital visitation rights have been a problem for LGBT couples.
In recent years, the number of religious congregations that have declared themselves "open and affirming" has grown from 1,000 to 4,000, Carey said.
"As we make progress, policies aren't matching up," she said.
Some areas needing attention, according to Carey, are marriage partners and immigration, insurance and marriage recognition in connection with military service.
She noted repeal movements in states that have passed same-sex marriage laws. She drew a parallel between the 53 percent support in polls for early-term abortions when Roe vs. Wade was decided and the 53 percent support for same-sex marriage in polls now. Both issues face opposition, she said.
A goal is to make support of LGBT protections widespread to counter opposition. Carey acknowledged that same-sex marriage has not been approved by referendums in any state and that Proposition 8, overturning same-sex marriage in California, passed. It is now suspended pending court action.
She explained the discrepancy between poll responses and voter behavior as the difference between "aspirational responses" to polls and actual belief. Also, she said, poll responders may not be those who actually vote.
"Every time we are getting closer and closer," she said.
Carey sees trends she finds encouraging. More young people have LGBT friends. The passage of Proposition 8 has energized support. And she observes Republicans supporting LGBT rights.


text:
Окса́на Петрі́вна Підгу́рська (* 1980) — українська волейболістка; майстер спорту України (2012).

З життєпису
Народилася 1980 року в місті Рівне. 2002 року закінчила навчання у «Міжнародному економіко-гуманітарному університеті імені академіка Степана Дем'янчука» — за спеціальністю «менеджмент організаціі». 2007 року здобула другу вищу освіту — в тому ж університеті закінчила факультет здоров'я, фізичної культури і спорту. Спеціаліст з фізичної реабілітації, викладач фізичного виховання.

В 1995—1997 роках — гравець-стажер ВК «Полісянка» (Житомир). 1997—2008 роки — гравець ВК «Регіна». У 2008—2009 роках — гравець команди ВК «Рось» (університет істам Біла Церква. З 2009 по 2010 рік — гравець команди ВК «Іхтісадчі» (Баку). 2010—2011 — в складі команди Керкінітіда. Від 2011 по 2013 рік — в складі команди ВК «Континіум університет»; брала участь у Кубку України з волейболу серед жінок 2011—2012.
Оксана закінчила волейбольну кар'єру як гравець у 2013 році, однак продовжує її, тренуючи жіночу збірну Рівненського Національного університету водного господарства та природокористування, а також працює фітнес тренером.

З 2003 року виховує доньку, Підгурську Кароліну Романівну, яка продовжила мамин спортивний шлях і також з 15 років грає в українській суперлізі (Клуби: 2018—2021 «Регіна МЕГУ», м. Рівне; 2021—2022 «Полісся ЖДУ», м. Житомир), з 2018 року була членом юніорської дівочої збірної, а також Кандидотом у майстри спорту не лише з класичного, а й з пляжного волейболу, адже неодноразово ставала чемпіонкою України саме з цього виду.

У сезоні 2022/23 захищає кольори клубу першої ліги «Новатор» (Хмельницький).

Джерела
 РОФВ
 Механізм функціонування фізичного виховання ВНЗ

уродженці Рівного
українські волейболістки
Волейболістки «Регіни» (Рівне)
Волейболістки «Керкінітіди»
Волейболістки «Волині»
Волейболістки «Полісся» (Житомир)
Спортсмени Баку
Волейболістки «Новатора» (Хмельницький)


This chain saw sharpening burr is just what the doctor ordered to sharpen your blade! Coated with diamond dust, this ensures that the blade will be sharpened quickly and well. 7/32", and made for a 1/8" shank.
This chain saw sharpening burr is just what the doctor ordered to sharpen your blade! Coated with diamond dust, this ensures that the blade will be sharpened quickly and well.
The total length is 1" with a 120 grit. For 7/32" chainsaw blades, and 1/8" shank diameter. This is a must have for anyone who works or dabbles in woodworking, home improvement, construction, or any kind of craft that requires a sharp chainsaw. The durable construction and diamond coating will ensure this burr will last.
Don't forget one of these for your toolbox!
7/32" sharpening burr Total length: 1 "
ASR Outdoor Snapatite 4 in 1 Utensil Set Lightweight Pocket-sized Cutlery 4pc $ 7.99	• 38% off!
Universal Tool Work Gloves Adult Outdoor Home Gardening Heavy Duty Accessory $ 6.99	• 46% off!


Many a time when Windows 7 is started, you may encounter with an error message 'Boot Configuration Data (BCD) file is missing. This error does not let you work on the computer as the operating system will not boot. This article will explain what is Boot Configuration Data (BCD) file, why BCD is important for booting the system & what action is to be taken to fix this error.
Boot Configuration Data (BCD) store, a registry like database, consists of various parameters that help in starting the operating system. It controls all phases of the boot process. Furthermore, BCD file is used in Windows Vista, Windows 7 & above versions in place of the text-based boot.ini file. In BCD store, objects like boot manager, boot loader & other boot applications have their own GUID. Besides, these objects can be modified using inbuilt tool Bcdedit.exe.
One of the main reason for occurrence of the "Windows Boot Configuration Data file is missing required information" error is that Bootmgr cannot be loaded as Boot Manager entry is missing in Boot Configuration Data store. This entry can be accidentally deleted or corrupted due to virus infection.
One more reason for this error appears is that Boot\BCD file is missing or corrupted in active partition.
Although the manual methods are time consuming, yet it will fix 'Boot configuration data is missing' error. What if your BCD error still exists & you cannot start your computer then either you will format the hard disk or reinstall Windows operating system. This situation can cause you to data loss. If for some reason your data have been lost and you want it back as quickly as possible then you can try windows data recovery software that helps you in getting back your lost, deleted, & corrupted data.


The CHI Easy Steam is a de-wrinkling game changer. It smooths your clothes with powerful steam, and the best part is, you barely have to lift a finger. That's because this innovative steamer eliminates the work of a traditional hand-held—no more standing over your fabrics, searching for that perfect angle or wondering if you missed a spot.
The magic all happens in the breathable, fabric garment bag. Simply hang from a convenient spot such as the back of a door, a shower rod or the closet. Then fill-up the easy to access water cup, located in the base of the bag. Next, place one item on the built-in hook and zip up the bag. With one tap of the button, the steaming begins. Most garments can be steamed in less than two minutes!
The CHI Easy Steam is a de-wrinkling game changer. It smooths your clothes with powerful steam, and the best part is, you barely have to lift a finger.
Put the finishing touches on your hair, make your morning coffee or finish folding the laundry, all while your attire is evenly steaming.
Remove water reservoir from the base of the steamer and fill it to the desired level. Hang your clothing inside the bag and zip it shut. Press ON to begin steaming.
Simply hang from a convenient spot such as the back of a door, a shower rod or the closet.
The garment bag collapses with a hook and loop strap for easy closet storage.


text:
MK17 8UD
Woburn Sands At a glance
On both platforms.
Step-free access to both platforms via short ramps, steep on the Bletchley side. Access between platforms via level crossing.
Accessible Booking Office Counter, Accessible Public Telephones, Accessible Taxis, Accessible Ticket Machines, Impaired Mobility Set Down, National Key Toilets, Staff Help Available, Wheelchairs Available
FOR SERVICES TOWARDS BEDFORD: In the event of engineering the bus/coach will collect from the bus stop outside the Station Hotel.
FOR SERVICES TOWARDS BLETCHLEY: In the event of engineering the bus/coach will collect from the bus stop after the level crossing, opposite the junction to Summerlin Drive.
We are open from 07:00 to 19:00 Monday to Friday and 08:00 to 16:00 on Saturdays, Sundays and all Bank Holidays except Christmas Day. A recorded message service is available outside of these hours.


text:
Alor Setar è una città della Malaysia, capitale dello Stato di Kedah.

Altri progetti

Collegamenti esterni


Today's post comes from my I-love-her-too-much-for-words baby sister, Alexandra Ghoman. (Who is not a baby anymore, but still.) Alexandra blogs at A Loves J about life as a not-so-newlywed, touching on topics as varied as faith, fashion, family, an adorable dog named Huckleberry, and the occasional semi-sarcastic guide to cruises. When she was still just a teenager, wise-beyond-her-years Alexandra was a great comfort to me during the years when we couldn't get pregnant. I'm sorry to say I am now returning the favor. If you, or friends you know, are experiencing infertility, know this: You are not alone. God hears; God sees; God cares.
she's a woman caught between stages. she's fixed somewhere between just married and happily ever after. she's not sure who she is. she's not sure who she's becoming. she's unrecognizable. she's ever-changing. she's ever the same. she's defined by this. she's undefined. she's all the things. she's none of them. there's a chance she's crazy.
she feels dramatic. she hates that. she wants to pray. she cries instead. when she cries, it's not soft and sweet. it's snotty, red-faced, and audible. she feels embarrassed. but she feels a little better when she stops.
she goes on living. breathing in, breathing out. she listens to friends. she congratulates good news. she smiles. she laughs. she aches and she aches. she answers "fine." she means it sometimes. other times, fine is a fine line. but overall, she's fine.
she doesn't want the moon. she doesn't crave the stars. she daydreams of normal. she dreams of no meds, no shots, no incessant blood tests. she dreams of pink lines and plus signs, nausea and swollen ankles, booties and sleep-deprivation. she vows to savor. she vows to never complain. she makes promises she knows she can't keep. she does it anyway.
nothing is bad. it's more the absence of good. she has seen what could be. she has felt what might be. she wishes it came easy. she wonders if it's her fault. she wonders if God knows, if God cares. she wonders what he's doing up there. she keeps going. she keeps praying. she keeps going.
she meditates on His promises. she wonders what it all means. she holds on for dear life. she rides the waves of uncertainty. she fixes her eyes on the Father. she paints his or her face in her mind. wondering what kind of special human is being prepared in the heavens. she thinks it must be someone special. someone she can't wait to meet. someone she's always known.
You can find Alexandra at A Loves J, on Instagram, and on Twitter.


text:
5-aminosalicylic acid-O-sulfates of physiologically acceptable bases, process for the preparation thereof and drugs containing same
5-Aminosalicylic acid O-sulfates of physiologically acceptable bases are new substances which are preparable by esterification of 5-nitrosalicylic acid alkyl esters with carbodiimide and sulfuric acid, alkaline saponification of the alkyl ester group and reduction of the thus obtained 5-nitrosalicylic acid O-sulfates. Said substances are useful as drugs, more specifically for the treatment of colitis ulcerosa, enteritis regionalis Crohn (morbus Crohn), chronic nonspecific colitis and diverticulitis.
Rokos, Hartmut (Berlin, DE)
Konczak, Heinz (Berlin, DE)
Forth, Wolfgang (Munich, DE)
Henning Berlin GmbH Chemie- und Pharmawerk (DE)
A61K31/60; A61P1/04; A61P29/00; C07C67/00; C07C301/00; C07C303/22; C07C303/24; C07C305/22; C07C305/24; (IPC1-7): A61K31/38; C07C71/00
260/505R, 558/37, 514/517
Other References:
Chemical Abstracts Index 79 53744 (1973).
Engel, J. Amer. Chem. Soc., 51, 3483 (1929).
SIEGEL, ALAN M
WEGNER & BRETSCHNEIDER (WASHINGTON, DC, US)
Parent Case Data:
This application is a continuation of U.S. application Ser. No. 047,518, filed May 6, 1987, now abandoned, which is a continuation of U.S. application Ser. No. 875,521, filed June 19, 1986, now abandoned, which is a continuation of U.S. application Ser. No. 625,620, filed June 28, 1984, now abandoned.
1. A pharmacologically acceptable salt of 5-aminosalicylic acid O-sulfate.
2. A salt according to claim 1 which is dibasic.
3. The salt according to claim 2 which is dipotassium 5-aminosalicylic acid O-sulfate.
4. A process for preparing salts of 5-aminosalicylic acid O-sulfate, which comprises esterifying 5-nitrosalicylic acid alkyl ester with a carbodiimide and sulfuric acid, hydrolyzing the resultant alkyl ester moiety under alkaline conditions, and reducing the thus obtained 5-nitrosalicylic acid O-sulfate.
5. The process according to claim 4, wherein the alkyl ester is the ethyl ester.
6. The process according to claim 4, wherein the carbodiimide is dicyclohexyl carbodiimide.
7. The process according to claim 4, wherein the hydrolysis under alkaline conditions is carried out by using a potassium hydroxide solution.
8. A pharmaceutical composition for treating inflammatory bowel disease comprising an effective amount of a pharmacologically acceptable salt of 5-aminosalicylic acid O-sulfate, and a pharmacologically acceptable carrier therefor.
9. The composition according to claim 8 wherein the salt is dipotassium 5-aminosalicylic acid O-sulfate.
10. A method for the treatment of inflammation of the intestines which comprises administering a therapeutically effective amount of a compound of claim 1.
11. A method for the treatment of inflammation of the colon which comprises administering a therapeutically effective amount of a compound of claim 1.
12. A method for making 5-nitrosalicylic acid alkyl ester O-sulfate comprising esterifying 5-nitrosalicylic acid alkyl ester with a carbodiimide and sulfuric acid.
13. The method of claim 12, wherein the alkyl ester is ethyl ester.
14. The method of claim 12, wherein the carbodiimide is dicyclohexyl carbodiimide.
15. The method of claim 12 further comprising hydrolyzing 5-nitrosalicylic acid alkyl ester O-sulfate under alkaline conditions to obtain 5-nitrosalicylic acid O-sulfate.
16. The method of claim 15 wherein hydrolyzing under alkaline conditions is carried out using a potassium hydroxide solution.
The present invention relates to novel pharmacologically acceptable salts of 5-aminosalicylic acid O-sulfate, processes for the preparation thereof and drugs containing same which are suitable for the treatment of colitis ulcerosa, enteritis regionalis Crohn (morbus Crohn), chronic nonspecific colitis and diverticulitis.
The standard preparation for the treatment of said diseases has so far been salazosulfapyridine. Said compound has mostly been orally administered and is probably bacterially decomposed in the colon to give the two metabolites 5-aminosalicylic acid and sulfapyridine. The metabolite 5-aminosalicylic acid has appeared to be the active component while the frequently observed side-effects are to be attributed to the metabolite sulfapyridine; cf. Khan et al., Lancet 2, 892 (1977). As 5-aminosalicylic acid is instable and virtually cannot be conveyed into the colon via the oral route, there has already been contemplated by Khan, loc. cit., the possibility of synthesizing a new substance which does not exhibit said drawbacks inherent to the known salazosulfaypyridine.
From German Offenlegungsschrift (Published Unexamined Patent Application) No. 30 27 013 by applicants there has been known an agent for treating colitis ulcerosa, enteritis regionalis Crohn (morbus Crohn), chronic nonspecific colitis and diverticulitis, which agent contains salicylic azobenzoic acid. Said agent is being successfully tested under clinical conditions. However, the salicylic azobenzoic acid contains an azo moiety which is rated to be toxicologically doubtful and, hence, should be avoided in drugs if possible.
PRESENT INVENTION
Therefore, it is the object of the present invention to develop other derivatives of the 5-aminosalicylic acid which derivatives will evade the disadvantages of salazosulfapyridine and can be therapeutically used in at least a manner comparable to that of the salicylic azobenzoic acid.
The present inventors have now found that pharmacological acceptable salts of 5-aminosalicylic acid O-sulfate are excellently suitable to serve said purpose and, in addition, have the advantage that they release the desired 5-aminosalicylic acid in the colon more uniformly and over an extended period of time.
5-aminosalicylic acid O-sulfate and pharmalogically acceptable salts thereof have so far not been described in the literature. Although there is apparent from the index of Chemical Abstracts that "Benzoic Acid, -5-amino-2-sulfooxy-" have already been described, in Chemical Abstracts 79, 53744 (1973) there has been only been referred to German Offenlegungsschrift 21 56 556 wherein unambiquously there has only been described the 5-amino-3-sulfosalicylate of nucleotide amino acid products. The 5-aminosulfosalicylic acid is a sulfonic acid which is formed by sulfonation of aminosalicylic acid. In contrast, the 5-aminosalicylic acid O-sulfate of the present invention is not a sulfonic acid but is a sulfuric acid ester of the phenolic OH group of the aminosalicylic acid. Said sulfuric acid esters so far have not been preparable by way of a direct synthesis.
In a paper by Engel on the cleavage of azo dyes by means of sulfites (J.Amer.Chem.Soc. 51, 3483 (1929) there is described a supposed preparation of 5-aminosalicylic acid O-sulfuric acid ester. However, this reported result must have been an obvious misinterpretation of experimental results, for the properties of the product then found are in no way in agreement with the those of the real 5-aminosalicylic acid O-sulfuric acid ester or of the 5-aminosalicylic acid O-sulfates according to the invention. Among other findings, the substance as described in said reference was stable against strong acids and was only decomposed to a slight extent upon boiling in a 5 mol/l hydrochloric acid for an extended period of time. Also, the experiments aiming towards a direct preparation of a 5-aminosalicylic acid O-sulfuric acid ester are not consistent with the possibility that at that time said substance would have been formed and recovered at all.
According to the present invention, 5-aminosalicylic acid O-sulfate can be prepared by esterification of 5-nitrosalicylic acid alkyl esters with carbodiimide and sulfuric acid, alkaline saponification of the alkyl ester group and reduction of the thus obtained 5-nitrosalicylic acid O-sulfate.
All lower alkyl esters may be considered as alkyl esters to be employed. The ethyl ester known from the literature is preferably used; cf. P. Thieme, J. fur prakt. Chem. 43, 453 (1891). However, the methyl ester, propyl ester or butyl ester may be used in the same way.
The esterification of the phenolic OH group according to the invention is effected by reaction with carbodiimides and sulfuric acid. All of the conventional carbodiimides suitable for the esterification can be used. Dicyclohexylcarbodiimide is preferably used. In the next steps, in an optional sequence, the alkyl ester group is saponified under alkaline conditions, and the 5-nitro group is reduced to yield a 5-amino group. The saponification of the alkyl ester group must be carried out under alkaline conditions, since the sulfuric acid esters of the phenol group are extremely sensitive to acids (sensitivity towards acids is so strong that free 5-aminosalicylic acid O-sulfuric acid decomposes within a short time). The reduction of the 5-nitro group to form a 5-amino group is effected in a per se known manner, in a particularly simple manner by catalytic hydrogenation under regular pressure or elevated pressure.
Depending on by which base the alkaline saponification is effected there is directly obtained the corresponding salt of the 5-aminosalicylic acid O-sulfuric acid ester. With view to the crystallizability thereof and, hence, the easy purification of the dipotassium salt, potassium hydroxide solution is preferred to be used as the base. However, other suitable bases such as sodium hydroxide may be employed.
The conversion of the dipotassium salt into other pharmacologically acceptable salts is accomplished in a per se known manner, for example by means of appropriately charged ion exchangers, by reaction with a solution containing a pharmacologically acceptable cation which forms a less soluble salt than the dipotassium salt, etc.
The pharmacologically acceptable salts of 5-aminosalicylic acid O-sulfate have the surprising property that they do not undergo any substantial decomposition in the small intestine. They, however, are slowly and uniformly decomposed in the large intestine/colon, probably by the action of the bacteria and enzymes as present therein, to form the desired 5-aminosalicylic acid and the physiologically acceptable sulfates. Thus, the substances according to the invention in an ideal manner allow the 5-aminosalicylic acid to be conveyed to the site of its desired efficacy.
Accordingly, the present invention further relates to pharmaceutical compositions containing pharmacologically acceptable salts of 5-aminosalicylic acid O-sulfate. It was certainly not foreseeable that such relatively low molecular weight salts of sulfuric acid esters are not substantially resorbed in the small intestine whereas they are decomposed in the desired manner so as to become available in the large intestine.
The salts according to the invention may be employed in the forms of tablets, dragees, but also as enemae. Since the decomposition is to occur only in the large intestine or colon or the rectum, the tablets or dragees according to invention are preferably soluble in the small intestine. To this end, for example, a recipe is selected in which the substances will only be dissolved in the alkaline medium of the small intestine. However, said goal is more readily achieved by coating the tablets or dragees with a known per se enteric coating such as that preparable by use of the Eudragit varnishes available from the company of Rohm, which film is soluble in the small intestine.
In the preparation of pharmaceuticals according to the invention all conventional excipients and auxiliary agents for the preparation of tablets and dragees maybe used. Said excipients and auxiliary agents include talc, starch, cellulose, polyvinlypyrrolidone, magnesium stearate etc.. More specifically, for the preparation of formulations soluble in the small intestine there are suitable polycarboxylic acids and and other polymers which are only decomposed or dissolved in an alkaline medium. The conventional coatings soluble in the small intestine do also mostly consist of such acidic polymers which are only decomposed or dissolved in an alkaline medium.
The cation portion of the salts of the present invention does not play a crucial role with respect to the activity and resorption. Thus, instead of potassium as already mentioned above, sodium, ammonium, calcium, magnesium, and the like may be used. Also salts of physiologically acceptable amines may be also employed in practice. Dibasic salts are preferred.
The tablets or dragees according to the invention generally contain from 0.3 to 1 g of pharmacologically acceptable 5-aminosalicylic acid O-sulfate salt. For the treatment of acute inflammatory processes, adults are orally administered a daily dose of from 1 to 6 g of the active ingredient. For relapse prophylaxis inpermanent therapy, 1 to 4 g distributed over the dayinto several individual doses will be sufficient. Since the side-effects as previously observed in the therapy with salazosulfapyridine have not been observed upon use of the agents according to the invention, the dosages may also be increased over those having so far been administered.
Therapy usually utilizes the oral route, while tablets or film dragees which are soluble in the small intestine are preferred to be used. Under particular circumstances, more specifically in the case that the residence time in the intestine is strongly reduced, there may also be used stomach-soluble tablets or dragees.
More particularly, in cases of a stationary treatment the utilization of enemae is also to be taken into consideration, in which treatment up to 100 ml of enema may be introduced once or several times a day. Such an enema preferably should contain 1 to 6 g, preferably 3 g, of 5-aminosalicylic acid O-sulfate salt in 100 ml solution. Enemae having been prepared in advance, thus, should contain from 10 to 60 g/l, preferably 30 g/l, of the active ingredient.
The following examples illustrate the preparation and effectiveness of pharmacologically acceptable salts of 5-aminosalicylic acid O-sulfate according to the invention.
With cooling by means of an ice bath, a cold solution of 10.14 g of 5-nitrosalicylic acid ethyl ester (P. Thieme, Journal f. prakt. Chem. 43, 453 (1891) in 60 ml of dimethylformamide (DMF) is added to a stirred solution of 74.26 g N,N'dicyclohexylcarbodiimide (DCC) in 80 ml of DMF. Then 3.8 ml of concentrated sulfuric acid in 60 ml DMF are added. The suspension is stirred in an ice bath for 1 hour and subsequently at room temperature for 22 hours.
After cooling in an ice bath, a cold solution of 6.75 g K2 CO3 (anhydrous) in 50 ml of water is added. The thus obtained mixture is added to 2.4 1 of stirred ice water. After allowing to sit in the ice bath for 75 minutes, the filtrate is separated from the precipitated dicyclohexyl urea. The filter residue is washed twice with 150 ml of water each. The yellow filtrate is concentrated to form a syrup; the latter crystallizes upon addition of 1,500 ml of diethyl ether and 60 ml of ethanol. Once the crystallization is completed, the product is separated by suction-filtration, then several times washed with diethyl ether and dried in a desiccator.
Yield: 16.7 g 5-nitrosalicylic acid ethyl ester O-sulfate (potasium salt).
Thin layer chromatography (TLC): Silicagel; iso-propanol/chloroform/methanol/water (37/37/ 19/7;v/v); Rf =0.74.
16.7 g of 5-nitrosalicylic acid ethyl ester O-sulfate (potassium salt) are dissolved in 790 ml of diluted potassium hydroxide solution (4.4 g of KOH) and allowed to stand at room temperature for saponification.
Then, diluted acetic acid is slowly added to the stirred mixture until a pH of 8 is reached. After the addition of 820 ml of water and 3.16 g of a Pd catalyst (10% on BaSO4, Degussa type E 50 N), hydrogen is passed through the mixture (a pressure vessel may be employed in order to accelerate the reduction).
Upon completion of the reduction (TLC; cf. above), the catalyst is filtered off by suction filtration, and the filtrate is concentrated to 90 ml. Then, 390 ml of anhydrous ethanol are added to the stirred concentrate. Upon completion of the crystallization, the product is filter off with suction, washed and dried in a desiccator.
Yield: 9.9 g 5-aminosalicylic acid O-sulfate (di-potassium salt).
Thin layer chromatography (TLC): Silicagel; iso-propanol/chloroform/methanol/water (37/37/ 19/7;v/v); Rf =0.0.
The decomposition of the sulfuric acid ester with 2 N hydrochloric acid at 110° C. or with aryl sulfatase (EC 3.1.6.1) (Boehringer Mannheim) yielded 5-aminosalicylic acid (TLC in the above system; Rf =0.38).
Prior to analysis, the product was once more precipitated from an aqueous solution by addition of ethanol. Colorless crystals; m.p. in excess of 280° C.
Elementary analysis: C7 H5 K2 NO6 S.H2 O (327.4)
C H K N S
Calc.: 25.7 2.2 23.9 4.3 9.8%
Found: 25.6 2.1 23.8 4.2 9.8%.
Resorption of 5-aminosalicylic acid O-sulfate di-potassium salt (ASA-S) in comparison with 5-aminosalicylic acid (ASA) and salicylic azobenzoic acid (HB-313).
The respective resorptions were tested in the small intestine of rats (2 to 5 animals each). ASA and ASA-S were assayed by HPLC and fluorescence detector:
Column: RP-18 (5 μm); 120 mm×4.6 mm;
Eluant: acetonitrile/0.2 M phosphate, pH 7.5/1.25 mM cetyltrimethyl-ammoniumbromide (30/5/65; v/v/v/);
Flow: 1 ml/min;
Detector: fluorescence, 315/500 nm.
μg/ml %
Initial Value 5.41 100
After 20 min 4.87 ± 0.39
ASA-S
Initial value 10.93 100
After 20 min 10.65 ± 1.60
2 ml of the dioxane solution were extracted with isoamyl acetate, re-extracted with sodium hydroxide solution and measured at 448 nm:
HB-313 μg/ml %
Resorption and Decomposition in a Voluntary Test Person.
ASA-S HB-313
Single Dose 2.74 300
corresponding to ASA (g)
(1.36) (1.60)
Ac-ASA Serum Level (μg/ml)
6 h 1.10 0.12
12 h 0.52 0.98
24 h -- 0.65
25 h 0.50 --
after administration.
Ac-ASA Accumulated Urine
Excretion (% of Dose)
24 h 4.91 9.17 48 h 8.16 10.02
ASA 5-aminosalicylic acid; ASA-S 5-aminosalicylic acid O--sulfate; Ac-ASA N--acetyl-5-aminosalicylic acid; HB-313 salicylic azobenzoic acid.
The above results show that ASA-S, in the same manner as HB-313, is substantially not resorbed in the small intestine, while, however, it then releases ASA in the large intestine uniformly and over a longer period of time than HB-313 does, the ASA being resorbed and excreted via urine. No side effects were observed with the test person.
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Club of "weird jerseys"
11 March, 2017 / History
Portuguese champion in 2000/01, Boavista has over 100 years of history. Established by the British, it stood out in the 90's. The checkered jerseys led it to become known in Italy as "the club of weird jerseys."
The British, which due to the business of Port Wine had a large community in the city, introduced football in Porto. The Boavista Footballers was set up in 1903, but few years later, due to a disagreement concerning the days when the matches should be held – the Portuguese preferred to play on Sundays whereas the British wanted to play on Saturdays – resulted in the subjects of His Majesty walking out on the club.
As Boavista Futebol Clube, it had a strong growth over the following decades. The main feature was winning the Portuguese Championship in 2000/01, but participation in European competition had been going on for some years. And it was in 1991/92 during a UEFA Cup qualifying match against Inter Milan, came up the nickname "club of weird jerseys," an allusion to the black and white checkered jerseys.
The Bessa Stadium, renovated for Euro 2004, has a museum with the history of the club, a walk of fame and two sculptures by José Rodrigues in which the panther, the club symbol , is highlighted.
Commercial Association of Porto – 181 years of history
6 March, 2017 / History
Despite the fact that it was officially founded in December 1834, the Commercial Association of Porto which dates back to the twelfth century, when trade and tradesmen, especially in coastal areas, were gaining more power.
Over the centuries, owing to its strategic location and the entrepreneurial spirit of its people, the city of Porto acquired great importance, becoming an important financial center in Europe and the world. It was at this stage that a shared "Trust fund" was established, created by merchants to cover risks and shipment losses of their commodities. This fund was recognized in 1295 by King Dinis and in 1402 by King John I.
However, until 1834 there was no organization of traders with legal status and competent to meet the needs of local entrepreneurs. At this point, meetings, the exchange of information, business and auctions were held in the "Juntina", located at the then Rua dos Ingleses. After the Liberal Revolution of 1822 and the enactment of the Commercial Code, the Juntina was the basis of the founding of the Porto Commercial Association, which is currently the second oldest Chamber of Commerce and Industry in Portugal mainland.
January 31, 1891 – A revolution that ended in bloodshed
3 March, 2017 / Culture, History
On January 31, 1891, the first attempt to establish the Republic took place in Porto. Discontented with the economic crisis and a British-launched Ultimatum, which called into question the Portuguese presence in Africa, a group of influential northern men led dozens of soldiers toward the center of the city with the intention of taking the Post Office and Telegraphs and proclaim the Republic. They were eventually blocked by the municipal guard, faithful to the Monarchy and placed on the steps of the Church of Santo Ildefonso.
The Republic came to be proclaimed on the balcony of the City Hall, which would be the last stronghold of the rebels. Those who did not die in the battle would eventually be taken to ships stationed at Leixões. Others managed to escape abroad. The Republic would only be proclaimed in 1910.
The memory of this date still remains today in the toponymy of the city, with Rua 31 de Janeiro, in downtown Porto, as well as in the streets that have the names of the authors of this frustrated revolution: Alves da Veiga, Rodrigues de Freitas or Alferes Malheiro.
Source: O Tripeiro (New Series) Year X number 1
All editions HeyPorto


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Destination4x4
The Journey is the destination
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Vanderbilt California
Posted on June 14, 2020 by Destination4x4
A metal headframe marks a vertical shaft in the mining district outside of Vanderbilt California.
Located in the New York Mountains, Vanderbilt California was an short lived gold mining town which lasted just a few short years, from 1891 to 1895. The mining district is found in the northeastern section of San Bernardino County, right at the California and Nevada Border and almost within sight of Primm, Nevada.
Old Plumbing remains in the town of Vanderbilt, CA
Gold was discovered in the New York Mountains, in January 1891 by a Piute Indian named Robert Black. Soon after, the news of the strike traveled quickly and there were several mines in operation, including the Gold Bronze, the Sagmore and the Boomerang. The district was named for the the Vanderbilt Family, in the hopes the gold strike would prove as rich as the Vanderbilt Fortune. A small camp was built to support the operation and with additional gold veins found in the fall of 1892, word got out and the rush started.
Two years later, in 1893, the small mining camp has attracted 150 people and boasted two stores, one saloon, three restaurants, stable, lodging house, a blacksmith shop and about 50 tents. The post office was added in February of 1893 and a Justice of the Peace, W. A. Nash was appointed. A weekly newspaper, the Shaft was soon published. A railway line and water works were planned, but never completed.
A horizontal mine shaft in Vanderbilt
A population of about 500 was found in the small town in 1894. In addition of adding more buildings and saw more saloons and businesses followed to service the town. Two ten-stamp mills were constructed at the two large mine sites, however the service was short lived. Almost as soon as the mills were built, the mines struck water and the ore changed and made it such that the mines could not recover gold. The town died with the gold production in 1895. 1895 also saw work on the railroad to Vanderbilt ceased. The school closed in 1898 and the Post office closed in 1910.
Exploring the ghost town of Vanderbilt, CA
Perhaps the towns biggest modern claim to fame was one of its famous citizens. Virgil Earp, older brother of Wyatt Earp and survivor of the infamous gunfight at the O. K. Coral, owned and operated a two story building which was served as saloon and hotel in the small town of Vanderbilt. It should be known that there were a lot of Earp Brothers, and there was a lot of migration during this period as populations moved quickly from town to town looking for fortune and opportunity.
Virgil Earp 1843 -1905
Town Summary
Town Name Vanderbilt
Location San Bernardino County, California
Latitude, Longitude 35.327222, -115.249722
Elevation 4350 Fett
Newspaper The Shaft
Post Office February 1893 – 1910
Vanderbilt Trail Map
Desert Fever – An overview of Mining History of the California Desert Conservation Area
The Historical Mining Towns of the Eastern Mojave Desert
Posted in Ghost Towns, Mines, Points of Interests | Tagged California, Mohave, San Bernardino	| Leave a reply
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Hot Creek Geologic Site
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Thursday January 28th 1926 I wrote to Winnie and Grace Taylor before lunch. Went down town to the Dr and to the office to come home with Ott. Letter from Hattie. Friday January 29th 1926 I was sewing in AM for Ott. Wrote Hattie and a note to Edith in PM. A light steady rain part of the day. We went after Ott. Home for supper. Saturday January 30th 1926 I did some work about the house and sewed some in AM. I read papers and rested awhile. I did some washing and ironing for myself. We went after Ott with Will Kee. We had supper at a place they serve Chinese dishes. Then to a show to The Metropolitan. A wonderful place. Home after midnight. Sunday January 31st 1926 It rained last night. I started to go out to Major Briggs. It was raining when I got to the city so I phones but they said come on. Major met me where I got of the car. A nice visit. They started to bring me home but found so much water on the streets. I got on a car. The Seiberts had company. Emily and her husband with friend. They had from Oregon. Monday February 1st 1926 It had stopped raining and was beautiful. I washed the dishes and cleaned the house which took till noon. Wrote Warner McCall. went to town about 3.30. At the doctors office. Letters from Lydia, Hattie, Cal Forney & Etta Edwards. Fannie Eavens home with us for supper.


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Judge grumbles at midnight 'ultimatum' forcing late-night hearing
A High Court judge has given lawyers and clients a warning about setting deadlines after receiving an evening email to say a hearing could not wait.
The Honourable Mr Justice Fancourt explained that his clerk was emailed by lawyers at 7.52pm last Thursday asking for an urgent hearing that same evening, to deal with the pre-pack sale of Nationwide Crash Repair Centres Ltd. The email was attached with weighty bundles, a skeleton argument and a certificate of urgency.
Initially it was thought that applications to appoint administrators would be heard the following morning, but another email from lawyers at 9.16pm said that a deal agreed with a purchaser would be pulled if not completed by midnight. The hearing was held by telephone that same evening and the order finally made at 11.56pm. It later transpired that the midnight deadline had been included in contract documents negotiated over the previous days.
Mr Justice Fancourt said there was nothing in the circumstances that required such urgency, and the deadline was only necessary because of terms agreed outside the court's control.
The judge added: 'It is wholly unacceptable for clients and lawyers and other professionals acting for them to negotiate terms that have the effect of presenting the court will an artificial ultimatum and require important matters affecting the livelihoods of thousands of people to be decided under undue pressure of time.'
He stressed that the court was not to be treated as a 'rubber stamp' for the appointment of administrators and that applicants should give time for a fair hearing to be held.
Administrators from PricewaterhouseCoopers LLP were appointed to handle the sale of the repair business to listed company Redde Northgate, which also owns law firms NewLaw Solicitors and Principia Law. The court was told that the sale would bring an immediate return to secured lenders of around £26.7m and save almost 2,900 jobs. The only realistic alternative was to force Nationwide Crash Repair Centres into liquidation, with all jobs lost and returns reduced to £19m.


Laguna Niguel, CA – August, 20, 2013 – Each blog post will include content on key balloon development and manufacturing insights, analysis and white papers from technical experts on design, manufacturing, quality and balloon forming equipment. Balloon design and manufacturing is a complex science that requires a mastery of material behavior, balloon forming technology, and quality control. Both extrusion and balloon forming are highly complex processes that involve a multitude of interacting parameters.
Some of these factors include material chemistry, material preparation, applied force, speed of stretch and forced stretch, rate of inflation, explosive expansion, exponential pressure decay, mold venting, heat flow, chamber pressure, and rate of cooling. Every step in the process must be completed with care and vigilance to produce high-performance balloons. Engineers with in-depth and hands-on expertise and knowledge will provide insightful technical content.
The educational site www.medicalballoonexperts.com will also have an Ask an Engineer section where questions can be responded to anonymously. Questions and responses will be posted on the blog site without the contact information to keep anonymity. Appropriate engineering and qualified staff will respond to the questions.
Interface Catheter Solutions is the only vertically integrated provider of outsourced solutions for balloon and catheter manufacturing. Interface has been solely focused on the balloon catheter market since 1995 and continually sets industry standards through process improvements and equipment advancements in balloon catheter manufacturing.
Interface has created more than 2,100 balloon designs, and offers balloon design and development, balloon contract manufacturing, extruded balloon tubing, custom medical extrusion, plus a comprehensive line of balloon catheter production and testing equipment. Interface is ISO 13485:2003 certified and operates multiple class 100,000 (ISO Class 8) clean rooms in three facilities. Interface's headquarters is located at 27721 La Paz Road, Laguna Niguel, California. www.interfaceusa.com Tel 949.448.7056.


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Recruiting Intelligence
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Nursing Jobs: Still Hard to Fill and Forecast Is It Won't Improve
By John Zappe May 6, 2014 July 22, 2015
With National Nurses Week beginning today, Wanted Analytics took a fresh look at the hiring demand for nurses and found, to the surprise of no one who recruits and hires these professionals, that the number of advertised positions continues to rise.
The recession the nation is still climbing out of dampened demand at the end of the last decade, but since, hiring has come roaring back. Wanted's report says the number of nursing jobs advertised online in the last 90 days was 18 percent higher than a year ago. Registered nurse was the most in-demand position, accounting for 63 percent of the posted jobs.
How many jobs does that represent? Wanted, which aggregates and analyzes help wanted postings from thousands of sites — corporate, agency, and job boards — reports there were 850,000 different nursing jobs online during the last 90 days. A little simple math tells us 535,500 of them were for RNs.
If those numbers seem high, they are. But that doesn't mean they're wrong. The U.S. Bureau of Labor Statistics in a December 2013 report calculated there will be 1.1 million RN jobs created by growth and replacement (retirements, etc.) in the 10 years between 2012 and 2022. But the number of RNs will only grow by 526,800 during that period.
A research study published in the American Journal of Medical Quality declares that by 2030 there will be "a total national deficit of 918,232 RN jobs." The study, "United States Registered Nurse Workforce Report Card and Shortage Forecast," graded each of the 50 states on the severity of their nurse shortage. In 2009, say the study authors, five states earned a D or an F. By 2030 30 states will get a D or an F.
Citing other studies, the authors noted that there's no disagreement there will be a shortage, it's just a matter of how big. Those other studies "project that there will be a national shortage of 300,000 to 1 million RN jobs in 2020."
If this isn't enough of an incentive to make National Nurses Week a blowout celebration of your nursing staff, consider the cost of turnover. The Journal of Nursing Administration put the pricetag at between $62,100 and $67,100. And that was back in 2005!
One more point: Last summer CareerBuilder found that 48 percent of nursing jobs and 39 percent of allied health jobs go unfilled for six weeks or longer. At 20 percent of health care organizations, nursing vacancies last three months or longer.
National Nurses Week ends next Monday, the 194th anniversary of the birth of Florence Nightingale. In between we recognize National Student Nurses Day (May 8) and School Nurse Day (May 7).
John Zappe
John Zappe was the editor of TLNT.com and contributing editor of ERE.net. John was a newspaper reporter and editor until his geek gene lead him to launch his first website in 1994. He developed and managed online newspaper employment sites and sold advertising services to recruiters and employers. Before joining ERE Media in 2006, John was a senior consultant and analyst with Advanced Interactive Media and previously was Vice President of Digital Media for the Los Angeles Newspaper Group.
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Rachel Brosnahan says working with Woody Allen was "inconsistent with everything I stand for and believe in"
Paul Drinkwater/NBC(LOS ANGELES) — Rachel Brosnahan is the latest actor to express regret over working with Woody Allen, who has been accused by his adoptive daughter of molesting her, a charge he has denied.
The actress, who recently won a Golden Globe for her performance in the Amazon series The Marvelous Mrs. Maisel, worked with the director on the Amazon limited series Crisis in Six Scenes.
"Look, I had a great experience working on that project," Brosnahan tells The Hollywood Reporter. "But I do have to take this opportunity to say that, for me, I have really struggled with the decision to do that project for a long time."
Brosnahan added, "Honestly, it's the decision that I have made in my life that is the most inconsistent with everything I stand for and believe in, both publicly and privately. And while I can't take it back, it's important to me, moving forward, to make decisions that better reflect the things that I value and my worldview."
\Allen's adopted daughter, Dylan Farrow, penned an op-ed in the Los Angeles Times questioning why the #MeToo movement has seemingly spared Allen.
After it was published, actress Greta Gerwig announced that she would never work with Allen again. Actor Timothee Chalamet announced on Instagram that he was donating his salary from his role in Allen's most recent film, A Rainy Day in New York, to charities that fight sexual abuse and harassment. Chalamet's co-star, Rebecca Hall, said she was "profoundly sorry" and was donating her salary to charity as well. And Mira Sorvino, who won an Oscar after starring in Allen's 1995 film Mighty Aphrodite, apologized to Farrow in an open letter in the HuffPost.
In 2014, Farrow wrote an op-ed piece in The New York Times, in which she told the story of how Allen allegedly sexually assaulted her at age 7.
She reiterated those claims to CBS This Morning co-host Gayle King on Thursday.
Allen has consistently denied the abuse allegation, maintaining his ex-partner and Farrow's mother, actress Mia Farrow, coached their daughter into making the claims. The director was investigated on child molestation claims for the alleged 1992 incident in Connecticut, but prosecutors elected not to charge him.


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What's the weather like in Ischia Porto in January?
If you want a break from the dull weather back home, head to the island of Ischia for milder temperatures and lots of beautiful sunshine. Ischia Porto is the largest town on the island and a great spot for stunning beaches, fine-dining restaurants and natural thermal springs.
Ischia Porto is a town on the island of Ischia, located off the coast of Naples in Italy. Ischia Porto weather in January is quite cold at times with regular strong winds coming in from the sea. Despite this, there's still lots of sunshine to enjoy each day during your stay, which makes January a great time to visit for outdoor activities such as horseback riding, hiking and sightseeing.
Temperatures reach highs of 13°C at this time of year, which makes January one of the coldest months of the year. You'll need to pack warm clothes to help deal with the cold at night, which can reach lows of 8°C along with winds of up to 10mph. Each day has nine hours of sunshine with humidity levels remaining steady throughout the month at 67%. The average rainfall is 37mm, which is slightly less than previous months.


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Die Roviva Roth & Cie. AG (Firma Roth & Cie AG) ist ein Schweizer Hersteller von Matratzen und Bettwaren in Wangen an der Aare im Kanton Bern.

Das Familienunternehmen entstand aus einer von Johannes Roth 1748 gegründeten Rosshaarspinnerei. Mit dem im Jahr 2000 gegründeten Biltener Unternehmen Riposa ist es eines der beiden letzten Matratzenunternehmen in Schweizer Hand. Roviva gilt als «landesweit bekannte Traditionsmarke».

Im Jahr 2007 produzierte Roviva 70'000 Matratzen und 45'000 Einlegerahmen.
2018 wurden pro Tag 120 bis 150 Matratzen und 100 Einlegerahmen hergestellt, davon wurden 92 % in der Schweiz verkauft und 8 % exportiert. 60 Mitarbeiter arbeiteten 2018 im Unternehmen.

Alleininhaber und Geschäftsführer von Roviva in der neunten Generation ist seit 2001 Peter Patrik Roth. Nachdem 2019 über Verbindungen von Roth ins rechtsextremistische Milieu berichtet wurde, etwa zum rechtsextremen Modelabel White Rex, gab der Schwinger Curdin Orlik bekannt, die Werbepartnerschaft mit Roviva nicht mehr zu verlängern. In seinem Rücktrittsschreiben als Vorstand des Wirtschaftsverbandes Oberaargau distanzierte sich Roth von jeglichem rechtsextremen Gedankengut.

Literatur
 Peter Paul Roth: Aus Tradition erfolgreich: 260 Jahre ununterbrochene Industriegeschichte "für gesunden Schlaf" der Familie Roth in Wangen an der Aare 1748–2008. Fischer AG für Data und Print, 2008, ISBN 978-3-905656-10-7.

Weblinks
 Website von Roviva
 Schlafkomfort in neunter Generation. In: Neue Zürcher Zeitung, 23. Oktober 2001.
 Regula Heinzelmann: «In Asien gilt die Schweiz als Qualitätssiegel». Interview, KMU-Magazin Nr. 6, 27. Juni 2019 (PDF)

Einzelnachweise

Unternehmen (Kanton Bern)
Wangen an der Aare
Gegründet 1748
Bettwarenhersteller
Produzierendes Unternehmen (Schweiz)


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WILKES-BARRE, Pa. – The Wilkes-Barre/Scranton Penguins announced today their roster for their 2018 training camp. Players who did not already skate as part of the team's introductory skate on Monday morning will report to camp on Tuesday, Sept. 25 and begin on-ice sessions that day at 10:30 a.m. at the Toyota SportsPlex.
The Penguins' training camp roster consists of 38 players: 23 forwards, 12 defensemen and three goalies. The Wilkes-Barre/Scranton training camp roster is as follows, and a printable PDF format of the roster is available by clicking here.
The Penguins initial roster includes 18 returning players from last season, as well as 11 players attending camp on a tryout basis. Like in years past, all practices at Toyota SportsPlex are free and open to the public.
The Penguins take the ice for their first preseason game when they host the Lehigh Valley Phantoms at Mohegan Sun Arena at Casey Plaza on Thursday, Sept. 27 at 7:05 p.m. The Penguins will battle the Hershey Bears in their second home contest of the exhibition schedule on Saturday, Sept. 29 at 7:05 p.m.