Applications for the upcoming OCAD INTAC courses will be accepted beginning June 28th. Details will be sent out and also posted here shortly.
INTAC held a very successful exhibition at the Osaka University of Arts in Japan during the month of May, Fifteen students and two faculty travelled to Japan to meet with counterparts from the participating countries. After a week of installation, opening, workshop and sightseeing activities, students broke off to travel on their own.
We had a couple of BBQs together over the summer here in Toronto and there was a great mix of old and new members of the INTAC family.
With registration almost complete, INTAC is set for another year. Plans are underway for a trip and exhibition in Osaka, Japan next May, 2017. With 'Turmoil' as a guiding theme, we expect challenging projects to emerge.
More INTAC info can be found at the new www.INTACnet.ca page, while our very first year of projects can be found at blog.ocad.ca/wordpress/docphoto.
Work on collaborative projects with students from universities around the globe in an informal, team-based environment with 10 OCAD U students, mentored by recent graduates. Work towards online presentations, book publications and international exhibitions. Travel in the summer term may be an option.
Our current collaborations feature students in Finland and South Korea, Germany and extend to India, UK and Brazil with the possibility to include new partners in the coming year. This past year's work culminated with half of the OCAD students travelling to Finland in May for a week of exhibitions and the other half travelling to South Korea for our exhibition there.
This hybrid studio course takes place over two semesters during which time students design and undertake collaborative projects with international partners. Directions identified by the group will vary from year to year, but address the ongoing goals of engaging global issues and communicating across cultures. Projects will be developed as online presentations/actions utilizing a variety of media although photographic, time-based and/or online formats are a primary focus. The course structure consists of a flexible meeting schedule, which includes group discussions, video conferencing sessions with partner schools (often very early in the morning) and considerable independent online communication. The scheduled course timeslot will be used in various ways and not every week.
This course is open to students in years 3 and 4 and credit will be granted at the student's year level. Acceptance to this course is limited and will be by prior written application. Students must be highly motivated and able to work well in an environment where activity is self-initiated and online communication is at the core of the process. With approval, this course may be repeated for credit.
Using group meetings, video conferencing and the online learning management system, as well as more public and popular social networking tools, students will communicate and develop projects under the guidance of the instructors at each school. Scheduling will be flexible, responsive to the needs of the activities while much of the work will be done on the students' individual time with their partners using various platforms: Skype, FaceBook, E-mail, Tumblr Blogs, OCAD's CANVAS system and other ones we find. Specific joint activities and projects will be articulated each year, based on specific partnerships and opportunities. There will be both short-term projects and those which develop over the 8 months of the course.
so prepare your application NOW. Applications will be reviewed and students accepted until the positions are filled. If accepted, you will be given an override so that you can complete the normal online registration for the course.
Note: It is highly recommended that you also register for a full load of courses during the registration period as all applicants will not be selected for this program. Once registered you can drop 2 studio courses.
Please provide: Name, Student Number, Program/Major, Year Level, Total number of Accumulated Credits (at least 10), Overall Average, home phone, mobile phone, e-mail address you will respond to over the summer.
Describe the primary media you are thinking of working in and how you would see collaborating with a group that is in different parts of the world. Describe any previous international experiences: living, travel, programs, languages, etc.
Discuss how this experience will fit your educational goals.


text:
module TheCityAdmin

  class UserBarcode < ApiObject

    tc_attr_accessor :id,
                     :barcode,
                     :created_at

    # Constructor.
    #
    # @param json_data JSON data of the user barcode.
    def initialize(json_data)
      initialize_from_json_object(json_data)
    end

  end

end

redpajama_set_name: RedPajamaGithub


Ruffle those feathers in this beaut white crop top. In a stretch fabric, this white crop top features a ruffle detailing and fastens with an exposed zip to the back. Perfect for drinks with the girls, or for that special occasion, style this sleeveless crop top with a midi skirt and heels to keep it classy!
♥ Underarm to hem measures 17cm approx.


text:
Q: C# - Use of compute shaders I'm trying to implement, using SharpDX11, a ray/mesh intersection method using the GPU. I've seen from an older post (Older post) that this can be done using the Compute Shader; but I need help in order to create and define the buffer outside the .hlsl code.
My HLSL code is the following:
struct rayHit
{
     float3 intersection;
};

cbuffer cbRaySettings : register(b0)
{
    float3 rayFrom;
    float3 rayDir;
    uint TriangleCount;
};

StructuredBuffer<float3> positionBuffer : register(t0);
StructuredBuffer<uint3> indexBuffer : register(t1);

AppendStructuredBuffer<rayHit> appendRayHitBuffer : register(u0);

void TestTriangle(float3 p1, float3 p2, float3 p3, out bool hit, out float3 intersection)
{
//Perform ray/triangle intersection
//Compute vectors along two edges of the triangle.
float3 edge1, edge2;
float distance;

//Edge 1
edge1.x = p2.x - p1.x;
edge1.y = p2.y - p1.y;
edge1.z = p2.z - p1.z;

//Edge2
edge2.x = p3.x - p1.x;
edge2.y = p3.y - p1.y;
edge2.z = p3.z - p1.z;

//Cross product of ray direction and edge2 - first part of determinant.
float3 directioncrossedge2;
directioncrossedge2.x = (rayDir.y * edge2.z) - (rayDir.z * edge2.y);
directioncrossedge2.y = (rayDir.z * edge2.x) - (rayDir.x * edge2.z);
directioncrossedge2.z = (rayDir.x * edge2.y) - (rayDir.y * edge2.x);

//Compute the determinant.
float determinant;
//Dot product of edge1 and the first part of determinant.
determinant = (edge1.x * directioncrossedge2.x) + (edge1.y * directioncrossedge2.y) + (edge1.z * directioncrossedge2.z);

//If the ray is parallel to the triangle plane, there is no collision.
//This also means that we are not culling, the ray may hit both the
//back and the front of the triangle.
if (determinant == 0)
{
    distance = 0.0f;
    intersection = float3(0, 0, 0);
    hit = false;
}

float inversedeterminant = 1.0f / determinant;

//Calculate the U parameter of the intersection point.
float3 distanceVector;
distanceVector.x = rayFrom.x - p1.x;
distanceVector.y = rayFrom.y - p1.y;
distanceVector.z = rayFrom.z - p1.z;

float triangleU;
triangleU = (distanceVector.x * directioncrossedge2.x) + (distanceVector.y * directioncrossedge2.y) + (distanceVector.z * directioncrossedge2.z);
triangleU = triangleU * inversedeterminant;

//Make sure it is inside the triangle.
if (triangleU < 0.0f || triangleU > 1.0f)
{
    distance = 0.0f;
    intersection = float3(0, 0, 0);
    hit = false;
}

//Calculate the V parameter of the intersection point.
float3 distancecrossedge1;
distancecrossedge1.x = (distanceVector.y * edge1.z) - (distanceVector.z * edge1.y);
distancecrossedge1.y = (distanceVector.z * edge1.x) - (distanceVector.x * edge1.z);
distancecrossedge1.z = (distanceVector.x * edge1.y) - (distanceVector.y * edge1.x);

float triangleV;
triangleV = ((rayDir.x * distancecrossedge1.x) + (rayDir.y * distancecrossedge1.y)) + (rayDir.z * distancecrossedge1.z);
triangleV = triangleV * inversedeterminant;

//Make sure it is inside the triangle.
if (triangleV < 0.0f || triangleU + triangleV > 1.0f)
{
    distance = 0.0f;
    intersection = float3(0, 0, 0);
    hit = false;
}

//Compute the distance along the ray to the triangle.
float raydistance;
raydistance = (edge2.x * distancecrossedge1.x) + (edge2.y * distancecrossedge1.y) + (edge2.z * distancecrossedge1.z);
raydistance = raydistance * inversedeterminant;

//Is the triangle behind the ray origin?
if (raydistance < 0.0f)
{
    distance = 0.0f;
    intersection = float3(0, 0, 0);
    hit = false;
}

intersection = rayFrom + (rayDir * distance);
hit = true;
}

[numthreads(64, 1, 1)]
void CS_RayAppend(uint3 tid : SV_DispatchThreadID)
{
if (tid.x >= TriangleCount)
    return;

uint3 indices = indexBuffer[tid.x];
float3 p1 = positionBuffer[indices.x];
float3 p2 = positionBuffer[indices.y];
float3 p3 = positionBuffer[indices.z];

bool hit;
float3 p;
TestTriangle(p1, p2, p3, hit, p);

if (hit)
{
    rayHit hitData;
    hitData.intersection = p;
    appendRayHitBuffer.Append(hitData);
}
}

While the following is part of my c# implementation but I'm not able to understand how lo load buffers for compute shader.
int count = obj.Mesh.Triangles.Count;
        int size = 8; //int+float for every hit
        BufferDescription bufferDesc = new BufferDescription() {
            BindFlags = BindFlags.UnorderedAccess | BindFlags.ShaderResource,
            Usage = ResourceUsage.Default,
            CpuAccessFlags = CpuAccessFlags.None,
            OptionFlags = ResourceOptionFlags.BufferStructured,
            StructureByteStride = size,
            SizeInBytes = size * count
        };
        Buffer buffer = new Buffer(device, bufferDesc);
        UnorderedAccessViewDescription uavDescription = new UnorderedAccessViewDescription() {
            Buffer = new UnorderedAccessViewDescription.BufferResource() { FirstElement = 0, Flags = UnorderedAccessViewBufferFlags.None, ElementCount = count },
            Format = SharpDX.DXGI.Format.Unknown,
            Dimension = UnorderedAccessViewDimension.Buffer
        };
        UnorderedAccessView uav = new UnorderedAccessView(device, buffer, uavDescription);
        context.ComputeShader.SetUnorderedAccessView(0, uav);

        var code = HLSLCompiler.CompileFromFile(@"Shaders\TestTriangle.hlsl", "CS_RayAppend", "cs_5_0");
        ComputeShader _shader = new ComputeShader(device, code);
        Buffer positionsBuffer = new Buffer(device, Utilities.SizeOf<Vector3>(), ResourceUsage.Default, BindFlags.None, CpuAccessFlags.None, ResourceOptionFlags.None, 0);
        context.UpdateSubresource(ref data, positionsBuffer);
        context.ComputeShader.Set(_shader);

Inside my c# implementation i'm considering only one ray (with its origin and direction) and I would like to use the shader to check the intersection with all the triangles of the mesh. I'm already able to do that using the CPU but for 20k+ triangles the computation took too long even if i'm already using parallel coding.

redpajama_set_name: RedPajamaStackExchange


This combo offers a Provençal dish that pairs the last of summer with a fresh vegetable pulled from the ground.
The gratin is one of those classic dishes that is both a vessel and a method of cooking — a shallow baking dish is filled with seasonal vegetables that are slowly baked to become meltingly tender and lightly crisped.
The traditional potato gratin is an über rich and heady mélange of potatoes, butter, cream and cheese, an all-time favorite. But in southern France, tomatoes are layered in with the potatoes to contribute their natural juices and sweet/tart flavors. This brightens the mix and lightens the role played by cream. A Provençal potato-tomato gratin bridges the seasons — the last of summer's tomatoes mingle with fresh potatoes just pulled from the ground.
Fresh potatoes sport thin, wispy skins and a crisp waxy texture. They are unlike those that have been "cured" or stored for a couple of weeks to toughen up the peel and dry the flesh.
Fresh potatoes can be any size, ranging from marbles to bakers.
To determine a potato's freshness, rub the skin with your thumb. It should be delicate enough to scrape clean. Look for fresh potatoes, now in our farmers markets, that are smooth without nicks or scrapes. Because they're not "cured," they won't last long, several days rather than weeks. Store at room temperature and don't refrigerate because their starches will begin to convert to sugar and they'll taste sweet.
Wait until ready to cook before washing because moisture expedites must and mold. Lightly scrub with a brush, then rinse quickly under running water. Once cut, use them as soon as possible. as they tend to turn brown if exposed to air for too long. Fresh potatoes are especially moist and perfect for the long, slow cooking a good gratin requires (and unlike store-bought potatoes, do not need to be precooked).
Using up the last of the season's tomatoes, both the ripe and the green, is immensely satisfying. Those that are still a bit hard, not fully red, need heat to become worth eating. When slow baked, they take on the flavors of their more mature cousins. Of the hundreds of different types of tomatoes, I prefer the cherry or Roma best for gratins because they're juicy and meaty, but any fresh, local tomato will work equally well.
Satisfyingly simple, this dish is perfect for entertaining for it may be assembled and baked ahead and gently reheated before serving. Yet, it's so homey and comforting, it's just right any night of the week.


Help your people! Join the fight against the chief skeleton and become the best hero in the dungeons.
Live a real adventure with this MMORPG online action game. Enjoy Dungeon Legends for free and discover an endless world of battles, quests and epic creatures.
Dungeon Legends is a Hack & Slash game optimized for mobile devices. A classic ARPG experience adapted to touch screens.
Fight against other players in multiplayer PvP like sand and become a legend of the dungeons. Walk the dungeons in search of incredible adventures and legendary treasures, or ask for help to pass the missions of the online multiplayer cooperative mode. Join a clan and fight epic battles to conquer the dungeons.
Combine your hero with your game. Turn your dwarf into a warrior, healer, hunter or epic protector. Train your hero in adventure missions and fight against other heroes in the field of multiple players online.
It was a long time ago, but the dwarves remember Skeleton Boss. He attacked the villages with his army of goblins, skeletons, trolls and balrogs. But the dwarves do not give up, they fear nothing and cooperate to hunt down their enemies and fight against this army.
The dwarves defeated the skeleton chief, forcing him to hide in the old dungeons.
Now the skeleton chief is back.
He calls an army to get out of his prison and take revenge on the dwarves.
The skeleton chief is waiting on his throne, deep in the dungeons. The only hope for the Dwarves is to find him, work together and hunt him before regaining his power.
Each search in this action RPG is unique. Unleash your arcane powers, beat them and hit the evil creatures with a good strategy to win legendary rewards. Chase evil in the campaign or participate in online multiplayer battles.
Fight epic PvP battles with other heroes or online multiplayer modes. Enter the arena alone or with friends and show that you are the best evil hunter in the dungeons.
Help your fellow players in PvE events and join them in the PvP battles. Each week, there is a new opportunity to prove that you are the best dwarf.
These MMORPG controllers are designed for touch screens. Hack & Slash game mechanics adapted to mobile devices.
Explore multiplayer adventures online with your friends. Collaborate with other online epic heroes to face the most difficult missions or fight against them in the multiplayer online PvP field.
Play a real action RPG adventure.
Enjoy the Hack & Slash mechanics.
Combat epic multiplayer battles against other online heroes.
Play PvP battles in the dungeons.
If you're looking for a new pirate and bar game and a mobile action role-playing game, this MMORPG adventure will be your new favorite role-playing game, action MMO, online RPG and PvP. Will you be the best dwarf? Get ready for incredible boss battles, legendary online PvE missions, cooperative multiplayer action levels and a new world of magic.
Download Dungeon Legends and you can install it on both your Android device and PC. Android device installation is very simple, just go to any third party APK provider and Download the APK and Simply Tap it to install and as for the PC version, you will be needing an emulator. Follow the Guide below to Download and Install the App on PC.
Step 1: To download and install Dungeon Legends for PC, you need an Android emulator such as Bluestacks to start with. I have given the links to their official sites at the end.
Step 3: If you find the application you are looking for, continue and download it; otherwise you just get APK of Dungeon Legends from any third party APK providers.
Step 4: That's it for installing Dungeon Legends for PC. Stay up-to-date for more comparable tips at DroidWikies.


Explore this gloomy, deep, powerful piano piece inspired by thoughts of death... and a model skeleton.
It's Chopin's most famous melody, known all over the world through its use in TV and films.
Chopin was fascinated by funeral marches, although hardly wrote any.
His doom-laden funeral march is actually the third movement of his Piano Sonata No. 2 in B-flat minor.
The sonata was published in 1839, but the Funeral March was finished earlier. The composer actually wrapped the rest of his sonata around the mournful march.
The funeral march, oddly placed as the third of four movements (usually in a sonata, the slow movement comes second) became the central focus of the sonata.
The story of the piece's composition is quite unusual (if true...). It begins with Chopin suffering from surreal nightmares, and going to rest in the studio of an artist friend (Felix Ziem).
Chopin's bizarre night terrors reminded Ziem of a joke he played in the studio of another artist friend. Ziem had found skeleton and sat it at the piano, making it look as if it was playing.
The skeleton was brought round that night. Chopin, feverish and pale, sat at Ziem's piano with it. Inspired by his nightmares and the deathly skeleton's presence, he improvised his funeral march then and there.
The Funeral March became incredibly famous, even to the point of becoming a parody, for a reason.
The slow, bleak, repetitive sounds echo the visions of doom which Chopin experienced in his nightmares. There is no escape: the raw blackness of the music destroys all hope, and swells with cries of grief.
Click to listen to and explore Chopin's nocturnes, which have a similarly gloomy feel to the funeral march.
I think the two darkest and most moving versions of the Chopin funeral march are played by Maurizio Pollini and Gyorgy Cziffra.
...click to read about the astonishing playing of Maurizio Pollini, one of the most popular pianists around.
Pollini's recording (Deutsche Grammophon, 1985) is perfectly controlled, and has an evil, hollow sound, evoking the emptiness of death.
Pollini stays true to every last nuance of the original score, and the result is a glimpse into Chopin's own doom-filled mind.
Cziffra plays slightly faster and with a little more breathing room, but with a deep feeling. He also has a kind of flexible sound, like a spade digging into the earth to make a grave.
His recording is part of a complete works of chopin set on EMI Classics Imports.
Explore more of Chopin's music!


Find the best TS3 servers CSGO on our topsite and play for free.
Teamspeak für Battle Royale Games und alles weitere, was aktuell so gezockt wird. Werde noch heute Teil unserer chilligen Community!
Играйте с нами играйте у нас!
Free teamspeak server for everyone to join. Possible to create own temporary channels. Follow the rules and be active to raise in rank.
Free TS3 for all ! Clan war world of tanks and atd .


text:
HOME Newsroom Shire News Releases INTUNIV® (guanfacine hydrochloride prolonged release), a non-stimulant for the treatment of ADHD, receives approval in Japan
INTUNIV® (guanfacine hydrochloride prolonged release), a non-stimulant for the treatment of ADHD, receives approval in Japan
a new non-stimulant clinical option for children and adolescents
from 6 to 17 years old with ADHD
Zug, Switzerland – 30 March 2017 – Shire plc (LSE: SHP, NASDAQ: SHPG) today announced that its partner in Japan, Shionogi & Co., Ltd, has received the approval of the Japanese Ministry of Health, Labor and Welfare to manufacture and market INTUNIV. INTUNIV is a new, once-daily non-stimulant indicated for the treatment of attention deficit hyperactivity disorder (ADHD),1 a common psychiatric disorder in children and adolescents.2,3
ADHD causes inattention, hyperactivity or impulsivity, or a combination of these symptoms,4,5 and can have substantial impact on all major areas of life, including: schooling, work and employment, behaviour, social functioning, self-esteem and health.6-9
INTUNIV is a selective alpha-2A adrenergic receptor agonist.1 With a unique mechanism of action, INTUNIV represents an additional treatment option in the management of ADHD.
"Shire is committed to ensuring that every person with ADHD is able to benefit from a treatment most suited to their needs," said Philip J Vickers, PhD, Global Head of Shire Research and Development. "The approval of INTUNIV marks a significant advance in the treatment of ADHD in children and adolescents in Japan, who may benefit from a new treatment option."
As part of the partnership, a Phase 3 placebo-controlled clinical study and long-term extension study evaluating the efficacy and safety of INTUNIV in 254 patients was conducted in Japan. In the trial, INTUNIV administered once daily showed significant improvements over placebo, as measured by ADHD-RS-IV total score, in all core symptoms of ADHD: hyperactivity/impulsivity, and inattention. The most common adverse events were somnolence in 146 patients (57.5%), decreased blood pressure in 39 patients (15.4%), and headache in 31 patients (12.2%).1
ADHD is a complex condition and approaches to treatment typically include educational methods, psychotherapy and medication.10 When required, either stimulants or non-stimulants are indicated as part of a comprehensive treatment programme for ADHD. Children and adolescents have a wide spectrum of individual needs as patients, so it is important that a range of treatment options are available. Non-stimulant medications are an important alternative to stimulants for some ADHD patients.10
About ADHD
Attention deficit hyperactivity disorder (ADHD) is recognised by the World Health Organization (WHO).2 Worldwide prevalence of ADHD is estimated to vary between 5.9% and 7.1%.3
Whilst the exact origin of ADHD is not fully understood, the area of the brain known as the prefrontal cortex is known to control several cognitive functions including attention and social behaviours,9, 11,12 and has been associated with some structural and functional abnormalities in individuals with ADHD.13-15
About INTUNIV
INTUNIV (guanfacine hydrochloride prolonged release) is a once-daily non-stimulant indicated for the treatment of attention deficit/hyperactivity disorder (ADHD) in children and adolescents from 6 to 17 years old.1
INTUNIV provides significantly improved ADHD symptom control vs. placebo1,16 and has a well-documented safety profile across the dose range.1
INTUNIV contains the active substance guanfacine, a selective alpha-2A adrenergic receptor agonist.1 Studies suggest that guanfacine may exert physiological effects by selectively stimulating the alpha-2A adrenergic receptor in the prefrontal cortex.17-18
INTUNIV is currently approved by Shire in the US, Canada, and Europe. Please refer to the local label for the approved indication.
INTUNIV Safety Information for Japan1
Precautions on Indication
The efficacy and safety of INTUNIV in children under 6 years of age or adults over 18 years of age have not been established.
If INTUNIV is continued after age 18 in patients who started pharmacological treatment with this drug before the age of 18 years, it should be administered with caution after the therapeutic benefits are weighed against the possible risks. The efficacy and safety of INTUNIV should regularly be evaluated, and if INTUNIV is of no value, it should be considered for discontinuation and must not be administered without purpose.
A diagnosis of ADHD must be made with caution, according to standard, established diagnostic criteria, including DSM* published by the American Psychiatric Association. INTUNIV must be used only in patients who meet such criteria.
*Diagnostic and Statistical Manual of Mental Disorders
Contraindication (INTUNIV is contraindicated in the following patients.)
Patients with a history of hypersensitivity to any of the ingredients of this drug.
Pregnant women or women who may possibly be pregnant.
Patients with atrioventricular block second degree and third degree. [The condition may get worse because of the central bradycardia effect of this drug.]
Careful Administration (INTUNIV should be administered with care in the following patients.)
1) Patients with a current or previous history of hypotension, orthostatic hypotension, bradycardia, or cardiovascular disease, or patients treating with drugs which can reduce blood pressure or pulse rate [INTUNIV may decrease blood pressure and heart rate.]
2) Patients with a current or previous history of hypertension [Blood pressure may increase when administration of this drug is abruptly discontinued.]
3) Patients with a current or previous history of arrhythmia, patients with congenital long QT syndrome or patients treating with drugs that are known to cause QT prolongation [QT prolongation may occur because of this drug.]
4) Patients with a current or previous history of ischaemic heart disease such as angina pectoris and myocardial infarction [If the acute reduction of blood pressure occurs, ischaemic heart disease may get worse because of the decreased coronary flow.]
5) Patients with cerebrovascular disorder such as cerebral infarction etc. [If the acute reduction of blood pressure occurs, the symptoms may be aggravated due to the decrease in cerebral blood flow.]
6) Patients with severe hepatic function disorder [The blood concentration of this drug may increase.]
7) Patients with severe renal function disorder [The blood concentration of this drug may increase.]
8) Patients in depressed state [The symptom may get worse because of the sedative effects of this drug.]
Important Precautions
1) Before prescribing INTUNIV, the physician or healthcare professional should fully inform the patient and his/her parent or other appropriate representative of its therapeutic position and potential risks, including adverse reactions to the drug, and instruct the patient on the proper administration method.
2) During long-term use of INTUNIV, the value of ongoing treatment should be periodically assessed and patients should not be administered without purpose.
3) Since syncope may occur when advanced decreases in blood pressure or pulse rate are observed, blood pressure and pulse rate should be measured prior to initiation of treatment of INTUNIV and 1-2 weeks after changing the dosage. Blood pressure and pulse rate should also be measured at intervals of once in 4 weeks after setting an optimal dose. Also, dehydration along with the administration of INTUNIV should be fully cautioned. If any dehydration symptoms are observed, proper care such as fluid replacement should be taken.
4) Since the effects on cardiovascular system (advanced bradycardia, hypotension, QT prolongation etc.) may appear, the following points should be cautioned before and during treatment with INTUNIV.
(i)The presence or absence of abnormality in ECG should be confirmed before treatment with INTUNIV. If any abnormality in ECG is observed, the initiation of administration should be carefully judged.
(ii)When INTUNIV is administered to patients with cardiovascular disease or with a medical history of cardiovascular disease, or any abnormality in ECG is observed before treatment with INTUNIV, patients' condition should be carefully observed by conducting routine ECG and so on.
(iii)Patients' cardiovascular condition should be cautioned during treatment with INTUNIV. If any symptoms suggesting the effects on cardiovascular system (bradycardia, syncope, dizziness, palpitations, etc.) appear, proper care should be taken by conducting ECG and so on.
5) Since suicidal ideation or behavior may occur, patient's condition should be carefully observed. Also, patients, the parents or other appropriate representative should be instructed to contact a medical institution immediately, if any suicidal symptoms occur.
6) While hostility and aggression are frequently observed in AD/HD patients, occurrence of these events during treatment has been also reported. The occurrence or worsening of these events should be carefully monitored during treatment.
7) Since INTUNIV may cause weight increase, body weight should be monitored regularly. If any symptom of obesity appears, proper care should be taken such as food therapy, movement therapy, etc.
8) Since sleepiness, sedation, etc. may occur, patients should be cautioned not to engage in operating potentially hazardous machinery, including automobiles during treatment.
This drug is primarily metabolized by the hepatic metabolizing enzymes CYP3A4 and CYP3A5.
Out of 254 patients evaluated for safety before NDA approval, adverse reactions (including abnormal changes in laboratory values) were observed in 190 patients (74.8%). Main adverse reactions were somnolence in 146 patients (57.5%), decreased blood pressure in 39 patients (15.4%), and headache in 31 patients (12.2%).
Clinically significant adverse reactions
1) Hypotension (≧5%), bradycardia (≧5%): Since advanced hypotension or/and bradycardia may occur and lead to syncope, patients' condition should be carefully monitored, measuring blood pressure and pulse rate regularly. If any of these symptoms appears, proper care such as dose reduction, interruption, or discontinuation should be taken.
2) Syncope (Incidence unknownNote 1): Since syncope may occur, patients should be fully observed. If any abnormality is observed, proper care such as discontinuation of administration should be taken.
3) Atrioventricular block (<0.5%): Since atrioventricular block may occur, proper care such as dose reduction, interruption, or discontinuation should be taken if any abnormality is observed.
Other adverse reactions
If the following adverse reactions occur, appropriate measures such as dose reduction, interruption, or discontinuation should be taken as necessary.
Type/ Incidence ≥5% <5%, ≥1% <1% Incidence unknownNote 1
Hypersensitivity Hypersensitivity, rash, pruritus
Cardiovascular Orthostatic hypotension Increased blood pressure Tachycardia, sinus arrhythmia, pallor, hypertensive encephalopathy
Psychoneurologic Somnolence, headache, insomnia, dizziness Irritability Nightmare, affect lability, agitation, sedation, asthenia Anxiety, depression, lethargy, convulsion, hypersomnia
Gastrointestinal Abdominal pain Decreased appetite, nausea, constipation, diarrhea, thirst, vomiting Abdominal discomfort, dyspepsia
Others Malaise Enuresis, increased weight Pollakiuria, increased ALT (GPT) Asthma, chest pain, dehydration
Note 1: The incidence of adverse reactions on the basis of overseas clinical studies and spontaneous reports is unknown.
Lauren Starr lauren.starr@shire.com +41 41 288 4443
About Shire
Shire is the leading global biotechnology company focused on serving people with rare diseases and other highly specialized conditions. We strive to develop best-in-class products, many of which are available in more than 100 countries, across core therapeutic areas including Hematology, Immunology, Neuroscience, Ophthalmics, Lysosomal Storage Disorders, Gastrointestinal / Internal Medicine / Endocrine and Hereditary Angioedema; and a growing franchise in Oncology.
Our employees come to work every day with a shared mission: to develop and deliver breakthrough therapies for the hundreds of millions of people in the world affected by rare diseases and other high-need conditions, and who lack effective therapies to live their lives to the fullest.
Statements included herein that are not historical facts, including without limitation statements concerning future strategy, plans, objectives, expectations and intentions, the anticipated timing of clinical trials and approvals for, and the commercial potential of, inline or pipeline products, are forward-looking statements. Such forward-looking statements involve a number of risks and uncertainties and are subject to change at any time. In the event such risks or uncertainties materialize, Shire's results could be materially adversely affected. The risks and uncertainties include, but are not limited to, the following:
Shire's products may not be a commercial success;
increased pricing pressures and limits on patient access as a result of governmental regulations and market developments may affect Shire's future revenues, financial condition and results of operations;
Shire conducts its own manufacturing operations for certain of its products and is reliant on third party contract manufacturers to manufacture other products and to provide goods and services. Some of Shire's products or ingredients are only available from a single approved source for manufacture. Any disruption to the supply chain for any of Shire's products may result in Shire being unable to continue marketing or developing a product or may result in Shire being unable to do so on a commercially viable basis for some period of time;
the manufacture of Shire's products is subject to extensive oversight by various regulatory agencies. Regulatory approvals or interventions associated with changes to manufacturing sites, ingredients or manufacturing processes could lead to, among other things, significant delays, an increase in operating costs, lost product sales, an interruption of research activities or the delay of new product launches;
certain of Shire's therapies involve lengthy and complex processes, which may prevent Shire from timely responding to market forces and effectively managing its production capacity;
Shire has a portfolio of products in various stages of research and development. The successful development of these products is highly uncertain and requires significant expenditures and time, and there is no guarantee that these products will receive regulatory approval;
the actions of certain customers could affect Shire's ability to sell or market products profitably. Fluctuations in buying or distribution patterns by such customers can adversely affect Shire's revenues, financial conditions or results of operations;
Shire's products and product candidates face substantial competition in the product markets in which it operates, including competition from generics;
adverse outcomes in legal matters, tax audits and other disputes, including Shire's ability to enforce and defend patents and other intellectual property rights required for its business, could have a material adverse effect on the Company's revenues, financial condition or results of operations;
inability to successfully compete for highly qualified personnel from other companies and organizations;
failure to achieve the strategic objectives, including expected operating efficiencies, cost savings, revenue enhancements, synergies or other benefits at the time anticipated or at all with respect to Shire's acquisitions, including NPS Pharmaceuticals Inc., Dyax Corp. or Baxalta Incorporated may adversely affect Shire's financial condition and results of operations;
Shire's growth strategy depends in part upon its ability to expand its product portfolio through external collaborations, which, if unsuccessful, may adversely affect the development and sale of its products;
a slowdown of global economic growth, or economic instability of countries in which Shire does business, as well as changes in foreign currency exchange rates and interest rates, that adversely impact the availability and cost of credit and customer purchasing and payment patterns, including the collectability of customer accounts receivable;
failure of a marketed product to work effectively or if such a product is the cause of adverse side effects could result in damage to Shire's reputation, the withdrawal of the product and legal action against Shire;
investigations or enforcement action by regulatory authorities or law enforcement agencies relating to Shire's activities in the highly regulated markets in which it operates may result in significant legal costs and the payment of substantial compensation or fines;
Shire is dependent on information technology and its systems and infrastructure face certain risks, including from service disruptions, the loss of sensitive or confidential information, cyber-attacks and other security breaches or data leakages that could have a material adverse effect on Shire's revenues, financial condition or results of operations;
Shire incurred substantial additional indebtedness to finance the Baxalta acquisition, which may decrease its business flexibility and increase borrowing costs; and
a further list and description of risks, uncertainties and other matters can be found in Shire's most recent Annual Report on Form 10-K and in Shire's subsequent Quarterly Reports on Form 10-Q, in each case including those risks outlined in "ITEM 1A: Risk Factors", and in Shire's subsequent reports on Form 8-K and other Securities and Exchange Commission filings, all of which are available on Shire's website.
All forward-looking statements attributable to us or any person acting on our behalf are expressly qualified in their entirety by this cautionary statement. Readers are cautioned not to place undue reliance on these forward-looking statements that speak only as of the date hereof. Except to the extent otherwise required by applicable law, we do not undertake any obligation to update or revise forward-looking statements, whether as a result of new information, future events or otherwise.
INTUNIV Prescribing Information, Shionogi & Co., Ltd 2017.
POLANCZYK, G. et al. (2007). The Worldwide Prevalence of ADHD: A Systematic Review and Metaregression Analysis. Am J Psych. 164:942-948.
WILLCUTT, EG. (2012). The Prevalence of DSM-IV Attention-deficit/Hyperactivity Disorder: A Meta-analytic Review. Neurotherapeutics. 9:490-499.
International Classification of Diseases, 10th ed., (ICD-10). World Health Organization 2007. Chapter 5,F90. http://apps.who.int/classifications/icd10/browse/2010/en#/F90-F98. Last accessed June 2014.
American Psychiatric Association. (2013) Diagnostic and statistical manual of mental disorders: DSM-5 (5th ed.). Arlington, VA: American Psychiatric Publishing.
DIAMANTOPOULOU S, et al. Impact of Executive Functioning and Symptoms of Attention Deficit Hyperactivity Disorder on Children's Peer Relations and School Performance. Dev Neuropsychol 2007; 32(1):521-542.
BIEDERMAN J, et al. Functional Impairments in Adults with Self-reports of Diagnosed ADHD: A Controlled Study of 1001 Adults in the Community. J Clin Psychiatry 2006; 67:524-540.
SHAW M, et al. A Systematic Review and Analysis of Long-term Outcomes in Attention Deficit Hyperactivity Disorder: Effects of Treatment and Non-treatment. BMC Medicine 2012; 10:99.
MANES, F. et al. (2002). Decision-making processes following damage to the prefrontal cortex. Brain. 125:624-639.
TAYLOR, E. et al. (2004). European clinical guidelines for hyperkinetic disorder - first upgrade. European Child and Adolescent Psychiatry. 13 Suppl 1:i7-i30.
WILKINS, AJ. et al. (1987). Frontal lesions and sustained attention. Neuropsychologia. 25:359-365.
ANDERSON, SW. et al. (1999). Impairment of social and moral behavior related to early damage in human prefrontal cortex. Nature Neuroscience. 2:1032-1037.
FARAONE S, et al. (2005) Molecular Genetics of Attention Deficit Hyperactivity Disorder. BioPsych 57:1313-1323.
RUBIA, K. et al. (1999). Hypofrontality in attention deficit hyperactivity disorder during higher-order motor control: a study with functional MRI. American Journal of Psychiatry. 156:891-896.
HOEKZEMA, E. et al. (2014). An independent components and functional connectivity analysis of resting state FMRI data points to neural network dysregulation in adult ADHD. Human Brain Mapping. 35:1261-1272.
HERVAS, A. et al. (2014). Efficacy and safety of extended-release guanfacine hydrochloride in children and adolescents with attention-deficit/hyperactivity disorder: A randomized, controlled, Phase III trial. European Neuropsychopharmacology. 24:1861-1872.
REN, WW. et al. (2012). Stimulation of α(2A)-adrenoceptors promotes the maturation of dendritic spines in cultured neurons of the medial prefrontal cortex. Molecular and Cellular Neuroscience. 49:205-216.
WANG, M. et al. (2007). Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex. Cell 129:397-410.

redpajama_set_name: RedPajamaCommonCrawl


Plato Media to iPod MP3 is a program to extract audio from video files.
It supports set beginning point and ending point to extract .
It also can capture video frames to Image files with format BMP, EMF, GIF, J2K, JPEG, PCX, PNG, RAS, TGA, TIFF, WMF.


This is the public profile of MING CHUN HSIAO, Additional information and high-resolution images are available for accredited press members, to access additional information about MING CHUN HSIAO please login as a press member.
2016, "2025: Forecasting Futures Exhibition", London College of Communication, With Cristina Mazzoni, Anna Vasiunyk, Marta Borkiewicz, Sims Chen, London/UK.
Press Members: Request an exclusive interview with MING CHUN HSIAO.


noun Feminist spelling of woman.
noun Feminist spelling of women.
From woman and women; respelled so as not to contain man/men.
He hates the word womyn, and anything with the suffix - centric.
The NYT story I linked to concerns the "about 100 below-the-radar lesbian communities in North America, known as womyn's lands (their preferred spelling), whose guiding philosophies date from a mostly bygone era."
These days, she and other members worry about the future of Alapine, which is one of about 100 below-the-radar lesbian communities in North America, known as womyn's lands (their preferred spelling), whose guiding philosophies date from a mostly bygone era.
D See, that post on "womyn" may have been humor, but I don't believe that it was reverse psychology.
When the time came for his presentation, one of the campus "womyn" sabotaged it by pulling the plug on a television set Scott intended to use to show a video, and refused to relinquish it while other onlookers attempted to shout him down.
Sort of like the way the spelling "womyn" is only used by people attacking feminism, not actual feminists.
I've also seen the spelling "womyn" used in earnest.
What compelled these "womyn" to round up the papers?
It might be some politically correct spelling of the word, like "womyn" instead of woman.
They choose the alternate spellings of 'womyn' and 'wimmin' to do this.
She, sorry--I apparently took you more seriously than you did yourself!
Interesting. The 'y' also has anatomical implications, n'est-ce pas? An extra dimension of symbolism.
Ain't no shame in the game!
ahem, edit: Oh, hello, yarb! That was directed at c_b.
Wouldn't this old chestnut have more credence if a similar pattern existed in all, or even most, other languages?
Allow me to take this opportunity to plug my list like a shameless hussy (the opposite of a goody or goodwife), even though it's only tangentially related to the conversation.
Oh yes! I wasn't serious.
And, by that logic (though faulty — woman is from wífman, a compound where wíf (wife) meant woman, and man meant human being), wife — which, for a time, after originally meaning "woman," meant "woman of lowly rank or employment" — should be just as reprehensible, yes?
I dislike it immensely, she, but I understand the thinking behind it--and it had nothing to do with spelling like a pop star. The spelling was coined to point out what feminists (in the "old" sense of the term) believed was an inherent bias in the English language, which in turn they believed reflected historical and social subordination of women. The spellings of "woman" and "women," they argued, suggest that women are a subset of men. It was an effort to "own" what they were called.
The whole premise, if I understand it correctly, was based on the argument that language can be a powerful tool in shaping how people perceive others and how they understand the world.
I've never understood this one. "Yes! We will distinguish ourselves by spelling like popstars."
I've also seen the variant wimmin.


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HomeGeneral NewsHow Baghdad plague led to Sephardi cultural revival
How Baghdad plague led to Sephardi cultural revival
March 31, 2020 Ian General News
http://jewishrefugees.blogspot.com/2020/03/how-baghdad-plague-led-to-sephardi.html
In these coronavirus days, Point of No Return is moved to reflect on the impact of epidemics through the ages. Quite a few affected the Middle East, and no doubt devastated the local Jewish communities. But the plague of 1743 brought an influx to Baghdad of 50 Sephardi families from Aleppo, led by Rabbi Sadka Hussein, born in 1699. Although he and his sons Nissim and Yacoub were to die in the plague of 1772 -3*, he exerted a significant Sephardi influence on Jewish cultural life in Baghdad.
According to Wikipedia:
In 1743 there was a plague in which many of the Jews of Baghdad, including all the rabbis, died. The remaining Baghdad community asked the community of Aleppo to send them a new Chief Rabbi, leading to the appointment of Rabbi Sadka Bekhor Hussein.[26]
Culturally, it would prove a decisive moment when Chief Rabbi Shmuel Laniyado of Aleppo picked his protegé for Baghdad. It is said he was accompanied by fifty Sephardic families from Aleppo.[27]
Many of them were Rabbis who were to sit on the Beth Din of Baghdad and Basra.[27]
This led to an assimilation of Iraqi Judaism to the general Sephardic mode of observance. Jewish culture revived, with communal leaders as Solomon Ma'tuk being renown for his work as an astronomer, library and piyyutim.[28]
The Ottoman empire in 1774
This brought the leading Jewish families of Baghdad, and with it, their Jewish practice into the network of Sephardic scribes and later printing presses established in Aleppo, Livorno and Salonica. Surviving records of the contents of the library of Solomon Ma'tuk shows a great number of books purchased from Sephardic scribes and some even originally from Spain.[29]
Further driving this process was the high esteem in which Rabbi Sadka Bekhor Hussein was held as a halakhic authority.[27] This saw him accepted as a halakhic authority by the Jews of Persia, Kurdistan and the fledgling Baghdadi trading outposts being established in India.[27]
Sephardic Rabbis and their rulings and practices were held in higher esteem. The historian Zvi Yehuda says the period saw the wheels turn in the relationship between the Babylonian Jewish communities and those of Iraq and Persia: "Before the 18th century, the Baghdadi Community needed the support of those communities; now the Baghdadi Community influenced them."[24]
The 18th century saw the Jewish community of Aleppo exert a significant influence over the Jewish communities of Baghdad and Basra not only culturally but economically.[27] Syrian Jewish families establishing themselves in Iraq were often formerly Spanish Sephardic families from Aleppo. These were typically high-class families such as the Belilios family who were frustrated with the dimming prospects of Aleppo and attracted to Baghdad and Basra's booming trade with India.
This process saw the leading Jewish families of Baghdad, Basra and Aleppo grow to be heavily interlinked through marriages, religious life, partnership and trade in the 18th century.[27]
As this process of cultural assimilation saw the Jews of Baghdad come to more closely resemble the Jews of Aleppo, economic decline in Syria, Kurdistan and Persia worsened. The 18th century saw a growing number of Jews leave from there to Baghdad, Basra or the Baghdadi-led outposts being established in the Far East.[27]
The still small and reemerging Jewish community of Baghdad became a migration destination with Jewish families settling in Baghdad from Istanbul, Aleppo, Damascus, Ana and Basra. A key driver of this was decline of the old caravan route running between these cities.[27]
There was also migration from the communities of Palestine, the villages of Kurdistan, and it is said that a handful of Jews settled in Baghdad from Germany.[27] By the early 19th century, Baghdad had been reestablished as a leading Jewish center in the Middle East. There were over 6,000 Jews in city, two synagogues and strong community institutions.[27]
This was not a golden age, however. Over time, the centralized Turkish control over the region deteriorated and the situation of the Jews worsened, but the population continued to grow very rapidly. An example of this deterioration is the persecution of Dawud Pasha, which began in 1814 and lasted until 1831. Many leaders of the Jewish community, such as Solomon Ma'tuk, were forced to flee. One of the foremost leaders of the community, David Sassoon, was forced to flee first to Busher and then to India.[30]
*This outbreak is recorded as being one of the most severe, killing an estimated two million people in Persia (Iran) and Persian-controlled lands to the west, including 250,000 in the city of Basra alone.


text:
Kylie Jenner: Billionaire, Keeping Up With the Kardashians, Kylie Cosmetics
by Kirti July 25, 2018 March 7, 2019 1 Comment on Kylie Jenner: Billionaire, Keeping Up With the Kardashians, Kylie CosmeticsPeople
In Mar 2019, At 21, Kylie Jenner became The Youngest Self-Made Billionaire Ever. Thanks to Kylie Cosmetics and a new deal with beauty retailer Ulta, Kylie Jenner has an estimated $1 billion fortune. "It's the power of social media," Jenner says. "I had such a strong reach before I was able to start anything." Some took issue with Forbes for calling Jenner – whose ritzy upbringing was documented on "Keeping Up With the Kardashians" – "self-made." As of 2018, with over 100 million followers, she is one of the top 10 most followed people on Instagram. Virat Kohli charges $120,000 for each Instagram post, Kylie Jenner tops the list with whopping $1mn. Who is Kylie Jenner? How is she related to Kardashians? What is the show Keeping Up With the Kardashians? What is Kylie Cosmetics?
On 4 January 2019, the @world_record_egg account was created, and posted an image of a bird egg with the caption, "Let's set a world record together and get the most liked post on Instagram. Beating the current world record held by Kylie Jenner (18 million)! We got this." The egg is known as Eugene. More details here
Why is Kylie so popular
What makes Kylie Cosmetics so popular?
Video on who are Kardashians?
Forbes and Kylie
SnapChat and Kylie
Kylie rise to fame
The Kardashian/Jenner family already takes over every social media platform there is from Instagram to Twitter, but Kylie really stands out from the rest. Analyzing Kylie's social media development, she went from being known as "Kim Kardashian's little sister" to one of the biggest celebrities known for her relationships, expensive cars and her own makeup line.
Many say she is popular due to her headline-grabbing selfies, bikini pictures and photos of her lavish life. But When Kylie chose not to go public with her pregnancy, her social media went quiet, which just intrigued followers even more. She's not afraid to shake things up trying up rainbow color hairs needs courage.
People love Kylie because not only does she live the luxury life, but she makes her social media platforms a space where she connects personally with her fans. After the launch of her makeup line, she retweets fan pictures and tweets of the products on her Twitter. Fans were crazy about this, not only was she reposting their pictures, but she was commenting and thanking them for their support.
Kylie allowed her fans into her life like no other celebrity. She constantly Snapchatted/Instagrammed what she was doing, who she's with and what she's wearing. Kylie's fans are directly linked to her world and feel as if they're there with her and she is telling them all these secrets. This connection with fans brings her closer to them, it builds a loyalty between the two. This inclusive feeling that fans get when they follow Kylie is what allowed her fan base to not only grow in numbers but also strength which is seen in the support for all her products.
Kylie uses her celebrity status and her loyal fan base with whom she interacts with every day to strengthen her business.
People buy Kylie's stuff because they wanna be Kylie. She created a perfect body/perfect looks and sold it to people.
In one of her interview, Ref , she offered an explanation as to why her personal app beat big sister Kim's own website in the iTunes charts.
She theorised: "I invite the cameras over and say, "Oh, hey, let's just do this." We do make-up tutorials and I'm laughing and talking. I know my fans are my age or younger than me, so, I just like to show my personality and show my fans my home and my dogs."
"I get really personal. I'm on Snapchat, and I'm just like them at the end of the day. Kim's more private. She has kids. It's just different."
Aside from Kylie Cosmetics, Jenner also earns money from her paid app, merchandise sold exclusively through her online store "The Kylie Shop," two apparel lines with sister Kendall Jenner, a book series and partnerships with retail brands like Puma and Quay Australia.
"I really do feel like people don't take me seriously as a business woman because of my age and my reputation," Jenner said on "Life of Kylie." "But I feel like they're starting to. I like to prove people wrong."
I can't leave the house without lipstick. Everyone was so interested in the color I was wearing. But nothing was ever perfect for me. I just thought, Why not make my own lip kit with a liner and lipstick?
For example, the smell of the lipsticks–I knew I wanted something sweet. I was in the lab, and they gave me 12 options, and I picked my favourite (She has tied with Seed Beauty for manufacturing )
What began as an online business selling lipstick for $29 each has earned Jenner's makeup company Kylie Cosmetics $420 million in sales in only 18 months. It is projected to rake in $1 billion in lifetime sales by 2022. Since its launch, the brand has expanded its makeup range to eyeshadows, blushes, highlighters and brushes. A bundle of these products priced at up to $325.
The popularity behind Jenner's products also stems from the limited number of products she makes available during each launch, which almost inevitably sells out each time.
Keeping Up with the Kardashians (often abbreviated KUWTK) is an American reality television series that airs on the E! cable network. The show focuses on the personal and professional lives of the Kardashian–Jenner blended family. The series debuted on 14 Oct 2007 and has subsequently become one of the longest-running reality television series in the country. Whether you love or hate them, the Kardashian-Jenner clan is one of the most influential families in Hollywood. They constantly set trends in beauty, fashion, and lifestyle.
Robert Kardashian (1944–2003) and Kristen Mary "Kris" Houghton married in 1978 and had four children together: daughters Kourtney (born 1979), Kim (born 1980), and Khloé (born 1984), and son Rob (born 1987). The couple divorced in 1991.
In 1994, Robert rose to prominence when he defended O. J. Simpson during the O.J. Simpson trial. for the murders of Nicole Brown Simpson and Ronald Goldman. Robert died in 2003, eight weeks after being diagnosed with oesophagal cancer
In 1991, Kris married retired Olympic decathlon champion Caitlyn Jenner (formerly known as Bruce Jenner before undergoing a gender transition in 2015). Kris and Caitlyn had two daughters together, Kendall (born 1995) and Kylie (born 1997).
The series, Keeping Up with the Kardashians, focuses mainly on sisters Kourtney, Kim, and Khloé Kardashian and their half-sisters Kendall and Kylie Jenner. It also features their parents Kris and Caitlyn Jenner (previously known as Bruce Jenner), and brother Rob Kardashian. The significant others of the Kardashian sisters have also appeared on the show, including Kourtney's ex-boyfriend Scott Disick, Kim's ex-husband Kris Humphries and Khloé's ex-husband Lamar Odom and ex-boyfriend French Montana. Despite the negative reviews, Keeping Up with the Kardashians has attracted high viewership ratings, becoming one of the network's most successful shows and winning several audience awards.
The Kardashian sisters began appearing in the media spotlight more often. In 2004, Kim became a personal stylist for recording artist Brandy Norwood. She eventually developed into a full-time stylist and was a personal shopper and stylist for actress Lindsay Lohan.
Khloé, Kim, and Kourtney ventured further into fashion, opening a high fashion boutique Dash in Calabasas, California.
In February 2007, a home sex video that Kim made with Ray J years earlier was leaked. Vivid Entertainment bought the rights for $1 million and released the film as Kim Kardashian: Superstar on February 21. Kim sued Vivid for ownership of the tape, but dropped the suit in April 2007 settling with Vivid Entertainment for $5 million. It is often assumed that the release of the sex tape was a major contributor to the rising fame of Kim Kardashian and her family.
The series' success has led additionally to the creation of numerous spin-off series, such as Kourtney and Kim Take Miami, Kourtney and Kim Take New York, Khloé & Lamar, Kourtney and Khloé Take The Hamptons, Dash Dolls, Rob & Chyna, and Life of Kylie. The network has also broadcast several television specials featuring special events involving members of the family and friends
This 5-minute video gives an overview of the Kardashians family
Kylie Kristen Jenner (born August 10, 1997) is an American reality television personality, model, entrepreneur, socialite and social media personality. She has starred in the E! reality television series Keeping Up with the Kardashians since 2007 and is the founder and owner of cosmetic company Kylie Cosmetics. As of 2018, with over 100 million followers, she is one of the top 10 most followed people on Instagram. Kylie Jenner is one celeb who knows how to be in the news, for good and bad reasons!
Virat Kohli charges $120,000 for each Instagram post is 17th in the list while Kylie Jenner tops the list with whopping $1mn. Selena Gomes with a price tag of 800,000 US dollars per post is at second position
According to Forbes magazine, her net worth is $900 million. This is mainly attributed to her having 100% ownership of Kylie Cosmetics. In an August 2018 issue of Forbes, they predicted that Jenner will become the next youngest billionaire ever.
In September 2017, it was reported that Jenner was expecting her first child with rapper Travis Scott. On February 4, 2018, she confirmed her pregnancy and announced that she had given birth to a daughter on February 1. On February 6, 2018, she announced via Instagram that she had named her daughter Stormi Webster
Kylie captivated cosmetics fans everywhere with the launch of three Kylie Lip Kits. Consisting of a lip liner and matt liquid lipstick, the $29 kits sold out within a minute and sent prices on resale sites soaring. Since then, her direct-to-consumer make-up range has expanded to include eyeshadows, blushes, makeup brushes and highlighters (or, as kyliecosmetics.com bills them, "kylighters").
Kylie Jenner is on the cover of Forbes' Aug 2018 "America's Women Billionaires" issue, with the magazine reporting that Jenner with net worth to be roughly $900 million, is the 27th-richest self-made woman in the United States. "Another year of growth will make her the youngest self-made billionaire ever, male or female, trumping Mark Zuckerberg, who became a billionaire at age 23," Forbes reported.
Some took issue with Forbes for calling Jenner – whose ritzy upbringing was documented on "Keeping Up With the Kardashians" – "self-made."
"We consider any person who built her own fortune, and didn't inherit the money, to be self-made," Forbes' methodology reads. "So top executives at tech firms who are compensated for helping significantly grow companies make the ranks but not second-generation-women running family businesses. For example, the richest woman in the world, Walmart heiress Alice Walton – whose net worth is estimated to be a whopping $46 billion – is not on the self-made billionaires' list because her wealth is inherited. The richest "self-made" woman in America, ABC Supply co-founder and chairperson Diane Hendricks, is worth just one-tenth of Walton's, at $4.8 billion.
Shares of the Snapchat sank 6.1 per cent on 22 Feb 2018, wiping out $1.3 billion in market value, following a tweet from Kylie Jenner who said she doesn't open the app anymore. Whether it's the demands of her newfound motherhood or the app redesign, the testament drew similar replies from her 24.5 million followers
Kylie tweet and snapchat
In 2012, she collaborated with the clothing brand PacSun, along with her sister Kendall, and created a line of clothing, "Kendall & Kylie". In 2015, Jenner launched her own cosmetics line called Kylie Lip Kits, which was renamed to Kylie Cosmetics the following year. She also released a mobile app that reached number one on the iTunes App Store.
In 2014 and 2015, Time magazine listed the Jenner sisters on their list of the most influential teens in the world, citing their considerable influence among teens on social media. As of 2018, with over 100 million followers, she is one of the top 10 most followed people on Instagram. In 2017, Jenner was placed on the Forbes Celebrity 100 list, making her the youngest person to be featured on the list. Jenner starred on her own spin-off series, Life of Kylie, which premiered on E! on August 6, 2017.
Egg, Instagram,Kylie Jenner and Mental Health
Rich People of the World
Jeff Bezos, Amazon,the Richest Man
Bill Gates, Microsoft, His Ideas of Success
Who is Jack Ma, What is Alibaba?
Is Money Good or Evil? Are Rich People Bad,Atlas Shrugged
What is Stock Market, Share,IPO,How to buy,sells shares
Abhijit
Nice post. Amazing, Virat Kohli charges 12000 dollars per Instagram post! Kardashian and Jenner family are amazing! Personal stylist for a celebrity! A great career indeed.


Even though, the ChromeVox was introduced as an accessibility solution for disabled users , I think it has lots of prospect for users with no disability.For instance you can be browsing in another tab , and the tab in the background can alert by telling exact situation that is going on on that tab in background.
What about speech recognition? Well… let me explain , with the speech recognition you can basically command the website handsfree.Speech Recognition has been a big difficulty to implement in old days even in desktop apps.But with the upcoming feature that is introduced with the Google Chrome it will only require you to write exactly nothing more than 2 words and a letter "x-webkit-speech".
<input type="text" x-webkit-speech="x-webkit-speech" /> Just like that the text input turns into a speech recognition enable input :).
Yea.. I'm aware that's quite an odd sentence but let me rephrase it.Actually the term is "Offline Web App.".
And with the camera support you can build and app that tracks hand gestures and scrolls up & down the page accordingly.
Thanks a lot to Sam Dutton & Paul Kinlan for great presentations.
Thanks a lot to Google Turkiye Team.
Thanks for the gifts Google.


This is a collection of English translations of Nazi propaganda material by Joseph Goebbels, part of a larger site on Nazi and East German propaganda. It includes many of his weekly articles for Das Reich, as well as a range of his speeches. Some of Goebbels's pre-1933 articles and speeches are available on the pre-1933 section of the German Propaganda Archive. The portrait was done by Wilhelm Otto Pitthan. For further information on the German Propaganda Archive, see the FAQ.
"Dr. Goebbels and his Ministry": A 1934 article by Hans Fritzsche.
Pictures of Goebbels speaking in 1935.
"On the Art of Speaking to the World": An introduction by an aide to Goebbels' book Die Zeit ohne Beispiel. It presents the Propaganda Minister in a flattering light.
31 December 1933: Goebbels looks back on Nazism's first year.
31 December 1938: Goebbels reviews 1938 and complains about complainers.
31 December 1939: Goebbels reviews 1939, and finds Germany innocent.
31 December 1943: Despite the disasters of 1942, Goebbels predicts German victory.
31 December 1944: The end is in sight, but Goebbels is not willing to admit it.
(1934): No speech on Hitler. Instead, Goebbels delivered a speech on the press.
"Our Hitler" (1937): Available in Landmark Speeches of National Socialism.
"German Women": Nazi views of women (March 1933).
"Radio as the Eighth Great Power": On radio (18 August 1933).
"The Racial Question and World Propaganda": Goebbels at the 1933 Nuremberg Rally.
Goebbels on Propaganda: His speech at the 1934 Nuremberg Rally. Available in Landmark Speeches of National Socialism.
"Communism with the Mask Off": His1935 Nuremberg Rally Speech.
"The Coming Europe": The Czechs must get used to German occupation (11 September 1940).
"Youth and the War": The German youth are fortunate... (29 September 1940).
"Christmas, 1941": Goebbels says Germans have a lot to be thankful for (24 December 1941).
Total War: The printed version of Goebbels's most famous speech (18 February 1943).
Total War: The spoken version. Available in Landmark Speeches of National Socialism.
"The Winter Crisis is Over": Goebbels remains confident of German victory (5 June 1943).
"In the Front Ranks": A memorial meeting for the victims of Allied bombing raids (18 June 1943).
"Immortal German Culture": Opening a wartime art exhibition (26 June 1943).
"The Festival of Strong Hearts�: Goebbels's last Christmas Eve address (24 December 1944).
"More Morality, Less Moralism": Goebbels wants freedom in the private sphere (27 January 1934).
The Battle of the Pharus Hall: A 1927 battle in Berlin.
Adolf Hitler as a speaker: Goebbels praises his master.
"What Does America Really Want?": Goebbels is unhappy with the USA (21 January 1939).
"The Coffee Drinkers": An attack on those who are dissatisfied (11 March 1939).
"Great Days": Goebbels on the end of Czechoslovakia (18 March 1939).
"The Morals of the Rich": Britain has no right to complain about Germany (25 March 1939).
"Children with their Hands Chopped Off": On British propaganda (24 June 1939).
"England's Guilt": Goebbels explains the reasons for World War II (Fall, 1939).
"Missed Opportunities": On the invasion of France (2 June 1940).
"Churchill's Lie Factory": Churchill, it seems, is guilty of the "big lie." (12 January 1941).
"Winston Churchill": On Winston Churchill (2 February 1941).
"The Veil Falls": The invasion of the Soviet Union had just begin (6 July 1941).
"Mimicry": An attack on the Jews (20 July 1941).
"The Door to a New Era": On foreign press criticism (28 September 1941).
"The Matter of the Plague": Why Germans may not listen to the BBC (5 October 1941).
"When or How?": Goebbels on the war situation (9 November 1941).
"The Jews are Guilty": An attack on the Jews (16 November 1941).
"The Pompous Giant": Why England will lose the war (23 November 1941).
"Roosevelt Cross-examined": Goebbels on FDR (30 November 1941).
"A Different World": The war after Pearl Harbor (21 December 1941).
"What is Sacrifice": Encouraging the home front during a hard winter (28 December 1941).
"The New Year": On the outlook for 1942 (4 January 1942).
"The Good Companion": On German radio policy (1 March 1942).
"Churchill's Trick": Goebbels is happy with Winston Churchill (1 March 1942).
"A Word to All": Encouraging courtesy (8 March 1942).
"An Open Discussion": Why food rations are being cut (29 March 1942).
"The Paper War": On bureaucracy and complaining during war (12 April 1942).
"Heroes and Film Heroes": Germans are better heroes than Americans (7 June 1942).
"The Air War and the War of Nerves": On British night bombing of Germany (14 June 1942).
"The Tonnage War": Goebbels on the U-boats (21 June 1942).
"The So-called Russian Soul": The Russian soul is of inferior quality (19 July 1942).
"God's Country": An unflattering portrait of the USA (9 August 1942).
"Don't Be Too Fair": Germans must be taught to hate (6 September 1942).
"What is at Stake": Encouraging determination to win the war (27 September 1942).
"The Optics of War": Preparing the public for Stalingrad (24 January 1943).
"The European Crisis": An anti-Semitic article (28 February 1943).
"Where Do We Stand?�: Not reprinted in a later book of Goebbels's work (2 May 1943).
"Driving Forces�: The Jews are trying to fool the world (6 June 1943).
"Morale as a Decisive Factor in War": Germany deserves to win (7 August 1943).
"The Realities of War": The war situation is favorable for Germany (22 August 1943).
"A Classic Example": The fall of Mussolini (19 September 1943).
"30 Articles of War for the German People": Support the war effort (26 September 1943).
"The New Year": An optimistic look to the future (2 January 1944).
"The Battle of Berlin": Goebbels discusses Allied bombing (13 February 1944).
"Why Are Things So Difficult for Us?": Germany's difficult situation (9 April 1944) .
"Life Goes On": On Allied bombing, with a hint of the V-weapons (16 April 1944).
"A Word about Enemy Air Terror�: Lynch captured Allied airmen (27 May 1944).
"The Background of the Invasion": A commentary on D-Day (18 June 1944).
"The Question of Revenge": The V-1 rocket bomb (23 July 1944).
"The Call of Duty": After the 20 July 1944 assassination attempt on Hitler (6 August 1944).
"The Higher Law": Germany will win because it is morally superior (24 September 1944).
"The World Crisis": The other side has it just as bad (17 December 1944).
"The Creator of the World's Misfortunes": The last major anti-Semitic essay (21 January 1945).
"A People on the Defensive�: Motivating Germans in the face of disaster (11 February 1945).
"Our Chance": Goebbels argues that Germany can still win the war (18 February 1945).
"The Year 2000": What will happen after Germany wins the war (25 February 1945).
"Look Confidently to the Helmsman�: Empty words of hope (4 March 1945).
"History as a Teacher": Goebbels resorts to historical parallels (1 April 1945).
"Fighters for the Eternal Reich": The Allies are near collapse, Goebbels says (8 April 1945).
"Risking One's Own Life": Goebbels is worried about Germans who surrender (15 April 1945).
"Resistance at Any Price": Goebbels's final published article (22 April 1945).


Migraines are a type of headache that specifically act on only one side of the head, although about 30% of patients with migraine may experience a bilateral headache. Migraine is a brain disorders that typically involve issues of the typical sensory processing that takes place in the brainstem. Possible causation has been linked to issues in blood vessels, blood flow, and oxygen levels in the brain. Migraine can be described in three phases, and common throughout the three phases is the importance of the neuropeptide CGRP and its role in migraine pathogenesis. CGRP increases in plasma have been linked to migraine headaches, and specific treatment plans have been tailored to account for this. CGRP is a vasodilator that causes dilation of cranial blood vessels and can lead to possible neurogenic inflammation in the periphery of its release while activating the pain pathway in the brainstem. The primary treatment for migraines is currently drugs from the triptan family and NSAIDs, as well as prophylactic drugs including antiepileptic drugs, beta-blockers, and Ca2+ channel blockers. The experiment conducted for this project aimed to determine the effects of a specific CGRP polyclonal antibody and CGRP receptor antagonist when it is with capsaicin, which stimulates sensory nerves. In an ex-vivo experiment using cell culture medium, the dura mater of mice is given either rabbit polyclonal antibody or a CGRP receptor antagonist or both, and then is challenged with capsaicin. CGRP positive (expressing) fibers and nerve terminals are examined under a fluorescent microscope in the dura mater of the mice.
Qureshi, Marvi, "Analysis of the Pathomechanism of Migraines with a Focus on Current Treatment Plans and the Role of the Neuropeptide CGRP" (2015). HIM 1990-2015. 1736.


what is the best foam mattress Puffy Mattress is a renowned vendor and also seller of memory foam mattresses. The Puffy is an USA-based business, and all of their products are manufactured here. Whereas, the foam which they make use of in their products is certified by CertiPUR-US. Those who are not prepared to get and afterwards try can go with Puffy' s FREE 101 NIGHT SLEEP TRIAL. Under this promotional deal, customers are permitted to take the bed mattress home for a 101 night long FREE test. As the trial period ends dissatisfied customers will have the ability to return their mattress for a complete return.
Besides readying in top quality, bed mattress from Puffy are shipped cost-free to your door. Therefore, you will have the ability to conserve a substantial quantity of loan by getting their products directly. The Puffy is an internet based store, which is why their products come with an affordable price. The lack of third celebrations, stores, suppliers, and so on gives them with great margins which they show their customers. Getting a Puffy Mattress is as simple as sending an email. Open their web site and there, you will certainly be able to buy by issuing 3 clicks approximately.
The Puffy as its discussed on their web site is offering handmade cushions. Well, in this age of industrialization it is quite difficult to discover real handmade cushions, and that is why our company believe Puffy is a good option. The feature-rich handmade cushions they are using had incredible benefits as well as a certain edge over various other mattresses which are produced through automated procedures.
The Puffy Mattress is developed to do its job regardless of its host surface area. Speaking you think about anything like level frameworks, box springs, adjustable structures, slats or perhaps the floor. Your bed mattress is mosting likely to generate very same results up until and unless you will not determine ahead up with something from regimens like gardens or open spaces.
An additional wonderful feature of their products is the consolidation of that company core support and cooling cloud which makes the mattress capable for adjusting each factor of your body perfectly, allowing you forget you believe that you are on a cushion. As far as the air conditioning mechanism of Puffy' s bed mattress is concerned, they have their own copyrighted innovation known as the cooling cloud( tm).
Puffy insurance claims that their bed mattress has some one-of-a-kind attributes which keep sleepers spinal column aligned while managing the pressure factors by eliminating them. It refers the fact that much better as well as audio rest can bring an extremely positive effect on your general emotional and physical health and wellness and health and wellbeing.
The bears assure for their mattress as long as a consumer possesses it. Well, Puffy' s we can not consider it as good as an orthopedic cushion yet still, it often tends to assist you to cope with stress factor relevant concerns as well as excessive pains.
Just like numerous various other companies the Puffy is operating with an extremely well made CSR project. Every year the firm invests a specific share of its income to acquire beds for the children in requirement. They, do it by giving away to several youngsters sanctuaries. Hence, favoring Puffy while trying to find a budget bed mattress can make you sign up with a very honorable cause.
Log on to their web site, choose a bed mattress dimension, pay online as well as that's all. The procedure of getting a cushion is not that basic on numerous other on the internet stores.
Puffy is a self-adjusting bed mattress, and it will certainly obtain accustomed to your needs within an hour or two – this features it an exceptional option for customers from various histories and age teams.
The Puffy have a strong group of experts busy in r & d tasks. Maybe this is the reason behind that high understanding contour this bed mattress maker is complying with.
what is the best foam mattress Puffy Mattress is a distinguished supplier as well as seller of memory foam mattresses. The Puffy is an USA-based company, as well as all of their items are manufactured below. Whereas, the foam which they use in their products is accredited by CertiPUR-US. Those who are not going to purchase and after that try could select Puffy' s FREE 101 NIGHT SLEEP TRIAL. Under this promotional deal, consumers are permitted to take the cushion home for a 101 night long FREE trial. As the test period expires unhappy consumers will certainly be able to return their cushion for a full return.
Aside from readying in top quality, cushions from Puffy are delivered cost-free to your door. Therefore, you will be able to save a significant quantity of cash by getting their products directly. The Puffy is an internet based store, which is why their products come at a sensible rate. The absence of 3rd parties, shops, suppliers, etc. supplies them with good margins which they show to their consumers. Purchasing a Puffy Mattress is as straightforward as sending an e-mail. Open their internet site and also there, you will have the ability to purchase by issuing three clicks approximately.
The Puffy as its pointed out on their site is supplying handmade mattresses. Well, in this age of automation it is rather hard to find genuine hand-made mattresses, which is why we think Puffy is a great selection. The feature-rich handmade bed mattress they are supplying featured incredible advantages and also a definite edge over other mattresses which are made via automated procedures.
The Puffy Mattress is designed to do its job no matter its host surface area. Speaking you think about anything like level frames, box springtimes, flexible frames, slats or perhaps the flooring. Your bed mattress is going to create very same results until and unless you won't determine to find up with something out of routines like gardens or open rooms.
An additional fantastic feature of their products is the consolidation of that firm core support as well as cooling cloud makings the bed mattress capable for adapting each point of your body completely, letting you forget you believe that you get on a mattress. As far as the air conditioning mechanism of Puffy' s cushions is concerned, they have their own patented technology understood as the cooling cloud( tm). The cooling cloud functions particularly. On the one hand, it presses warm out of your bed mattress while on the other hand, its cloud gel layer assists you in keeping your body temperature at an ideal degree.
Puffy insurance claims that their mattress has some special attributes which maintain sleepers spinal column aligned while taking care of the stress factors by eliminating them. It is an issue of that much better and also sound rest can bring an extremely positive influence on your overall emotional and also physiological health and wellness as well as health and wellbeing.
The bears assure for their bed mattress as long as a consumer has it. Well, Puffy' s we can not consider it as excellent as an orthopedic bed mattress but still, it tends to assist you to cope with pressure factor associated concerns and also undue discomforts.
Just like numerous various other companies the Puffy is operating with an extremely well designed CSR task. Yearly the firm invests a specific share of its revenue to purchase beds for the youngsters in demand. They, do it by giving away to several kids shelters. Therefore, liking Puffy while seeking a budget bed mattress could make you join a very worthy reason.
Think it or not, acquiring puffy is as easy as sending an e-mail. Log on to their internet site, pick a mattress size, pay online as well as that's all. The process of buying a bed mattress is not that simple on numerous other on the internet stores. They have assimilation with virtually all the significant monetary instruments for repayment processing.
Puffy is a self-adjusting bed mattress, as well as it will certainly get accustomed to your demands within a hr or so – this showcases it an outstanding option for customers from different histories and also age teams.
The Puffy have a solid group of experts hectic in study as well as advancement activities. Maybe this is the factor behind that steep understanding contour this mattress maker is following.
what is the best foam mattress Puffy Mattress is a renowned vendor and vendor of memory foam bed mattress. Under this promotional offer, customers are enabled to take the bed mattress home for a 101 night long FREE trial. As the trial period ends dissatisfied consumers will be able to return their cushion for a full return.
Apart from being good in high quality, cushions from Puffy are delivered totally free to your door. The Puffy is a net based store, and that is why their items come at a sensible cost. Buying a Puffy Mattress is as easy as sending out an email.
The Puffy as its stated on their website is providing handmade cushions. Well, in this age of industrialization it is fairly difficult to discover genuine hand-crafted cushions, and also that is why our company believe Puffy is a great option. The feature-rich handmade mattresses they are using come with incredible advantages and also a certain side over various other cushions which are made via automated procedures.
The Puffy Mattress is developed to do its work despite its host surface. Talking you take into consideration anything like level structures, box springs, flexible frames, slats or perhaps the floor. Your cushion is going to generate same results till and also unless you won't decide to come up with something from regimens like gardens or open rooms.
One more excellent function of their products is the unification of that company core assistance as well as cooling down cloud which makes the cushion qualified for adjusting each point of your body perfectly, allowing you neglect you assume that you are on a cushion. As much as the cooling mechanism of Puffy' s mattresses is concerned, they have their very own trademarked modern technology known as the cooling cloud( tm).
Puffy cases that their cushion has some unique features which maintain sleepers back aligned while taking care of the stress points by eliminating them. It is a matter of that better as well as sound rest could bring a really favorable effect on your overall mental as well as physical health and wellness as well as well-being.
One more fascinating point about Puffy, worthwhile to be mentioned right here is that lifetime service warranty they are using. It is not similar to the other typical guarantees being provided these days. The bears ensure for their bed mattress as long as a consumer has it. Well, Puffy' s we could rule out it just as good as an orthopedic cushion but still, it has the tendency to help you to handle pressure point relevant concerns as well as undue pains.
Much like many various other companies the Puffy is running with a quite possibly created CSR task. Yearly the company spends a specific share of its revenue to acquire beds for the kids in demand. They, do it by donating to a number of children shelters. Thus, favoring Puffy while looking for a budget mattress can make you join a very noble reason.
Log on to their web site, pick a cushion size, pay online as well as that's all. The process of purchasing a bed mattress is not that basic on various other on-line shops.
Puffy is a self-adjusting mattress, and it will get accustomed to your demands within a hr approximately – this showcases it an excellent option for consumers from different histories as well as age groups.
The Puffy have a solid team of professionals hectic in research study and development tasks. Perhaps this is the reason behind that high learning curve this mattress manufacturer is following.


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Q: É possível ter um sistema operacional com vários kernels? Eu estava pensando junto com minha equipe fazer um sistema operacional que rode as aplicações e drivers do Windows e Linux, seria usado como base o kernel do Linux e do React OS em um kernel híbrido, mas eu estou curioso em saber se seria possível ter mais de um kernel.

A: Se você está perguntando isso você e sua equipe estão longe de fazer um sistema operacional simples, mais ainda um complexo assim. Tenha em mente que ninguém fez isso não por que não tiveram a ideia, mas sim por não ser factível e/ou não traz as vantagens que se espera.
Em tese é possível, mas deve ser extremante difícil e na prática provavelmente precisará de um kernel para gerenciar os demais. E nem sei se tem alguma vantagem nisso. Se adicionarem alguma coisa no processador pode ser mais fácil fazer assim. As máquinas virtuais se tornaram "fáceis" de implementar e viável no uso depois que o processador passou ter controle próprio para isto.
Isso vale para qualquer coisa do sistema operacional. Sempre deu para fazer memória virtual, mas só ficou viável quando o processador passou ter mecanismo próprio de controlar isso sem custo para o software.
Teria que se perguntar qual a vantagem de ter vários kernels. Provavelmente nenhuma. Quer fazer drivers e aplicações diferentes? Ok, faça isso funcionar, não precisa ter mais que um kernel. A API do OS nada tem a ver com o kernel. Disponibilize APIs diferentes no mesmo kernel.
Uma coisa é você desenvolver um sistema operacional com vários kernels ou várias APIs, o que na prática não vejo vantagem direta, outra bem diferente é desenvolver um ou mais kernels disponibilizando APIs existentes com 100% de compatibilidade.
O ReactOS até hoje não conseguiu 100% de compatibilidade com o Windows XP, e próximo de zero, se eu não estiver desatualizado, com o que foi adicionado no Vista, 7, 8, 10 e 11. Inclusive os drivers dele são incompatíveis com os drivers atuais do Windows.
Se fosse fácil, ou mesmo factível, o Linux teria dado compatibilidade com os drivers do Windows, isso teria dado um salto na sua adoção. Não deixaram de fazer porque não tiveram a ideia ou faltou vontade de ter feito.
Compatibilizar aplicativos já é um pouco mais fácil, mesmo assim precisa esforço e muita competência. A Microsoft investiu nos seus melhores engenheiros, e boa parte dos melhores do mundo trabalham lá, e conseguiram fazer duas coisas: conseguiram disponibilizar a API de usuário do Linux no Windows, então hoje "qualquer" aplicação Linux roda no Windows nativamente; e fizeram o SQL Server que é muito integrado com o Windows rodar no Linux integralmente, sem modificações (estão fazendo modificações para otimizações), e isso abre a possibilidade de quase qualquer aplicação Windows poder rodar no Linux. Ou seja, ainda não está 100% madura, mas já existe o que deseja.
O que está se fazendo hoje em dia é usar máquinas virtuais completas ou não para rodar mais de um sistema operacional na mesma máquina ao mesmo tempo e se comunicarem de tal forma que seja quase transparente quando está rodando uma aplicação no Windows, Linux ou outro OS, apesar que só um deles é o host e os demais são guests. O próprio Windows tem tecnologia que faz isso para rodar aplicações antigas que não rodam mais nas versões mais novas.
Outro dia vi um grupo de pessoas que se propuseram fazer um sistema operacional livre de bugs. É muita ingenuidade achar que os outros erram porque são burros, preguiçosos, sem criatividade, ou coisa do tipo. Se não fizeram é porque, no mínimo, não vale o esforço.
Eu acho que com o hardware atual na prática vai acabar fazendo o que já existe. O melhor que daria é fazer um nanokernel que fique disponível para os demais kernels trabalharem.


Sao Paulo is the industrial and financial capital of Brazil, but it is also gaining status as a hot spot for the privileged crowd. The city has a population of 18 million, many whom are of Italian, Japanese and Lebanese descent, although, much of its culture still comes from the rest of Brazil, including its infamous sister city, Rio de Janeiro. Though not as well known, Sao Paulo is the biggest city in South America. There is no shortage of elite services offered here and dining choices are an ethnic smorgasbord, many unsurpassed worldwide. Sao Paulo is 2500 feet above sea level, but only 45 miles from the coast. This makes for a pretty spectacular drive to the beach. Paulistos have a unique style, setting them apart from the people of other major cities of the world and making it understandable why air traffic to this city has tripled in the last few years. Should you go, you will leave with a fresh understanding of what South America has to offer.
Take a break from the city's intense urban landscape in Ibirapuera Park, a combination of New York's Central Park and its Museum Mile. A nice place to people-watch on weekends, you can rent a bicycle or sip coffee at one of the various cafés, including Cafe Museu de Arte Moderna. The ponds near the planetarium (which is currently undergoing renovation) are attractive and a row of geysers rise and fall like pistons, starring in a sound-and-light show on Saturday and Sunday nights at 8pm. Visit the new Ibirapuera Auditorium, designed 50 years ago by Oscar Niemeyer but only recently inaugurated.
The traditional venue for classical concerts, the impossibly grand Theatro Municipal is also the home of the São Paulo City Ballet. A cultural landmark in Sao Paulo, the Theatro has maintained its popularity through the years.
For an afternoon dose of creativity, head to the most important museum in Brazil. Since it's opening in 1968, this building has housed several European masters. The structure itself is quite a spectacle, with the main part of the building being supported by four colossal, red pillars.
If you want more Brazilian art, head inside this gorgeously restored museum that features some of the country's best artists.
About 1.5 million Paulistanos are of Japanese decent, and this museum chronicles how they got here in the late 19th century. History buffs won't want to miss this.
An elegant and tasteful establishment, the Jockey Club is the ideal place to escape the chaos of the city and place bets on horses. Dine at one of three exclusive restaurants: Mercearia, The Canter, and Charlo. Don't forget to bring a lucky charm or an eye for a good horse.
A 1950 house museum surrounded by a lush tropical garden with 25,000 trees.
Gallery that shows contemporary work by Brazilians as well as Americans.
Gallery devoted to established and up-and-coming artists from Brazil.
A public food hall that resembles a United Nations bazaar. The 135,000-square-foot space is packed with fresh fish, ripe cheese and strange fruits.
It is a venue for symphonic and chamber presentations, and has been designed according to the most up-to-date international standards, comparable to the Boston Symphonic Hall, Musikvereinssaal in Vienna and the Concertgebouw in Amsterdam.
A palm-lined garden where bands play sertanejo music (Brazilian country tunes) from a gazebo-like bandstand.
Not as glamorous as it once was, it is still one of the top restaurants in town. Affluent locals pack into this Classic Brazilian barbeque house where beef is the speciality. Your sirloin is grilled tableside and with its delicious salads and appetizers plus a comfortable environment, it is considered São Paulo's one of the best steakhouses.
Hailed as the most beautiful restaurant in the city, Figueira (fig tree) Rubaiyat is built around a magnificent old fig tree. The menu specializes in a la carte meats; most of the beef, chicken, and other meats served at Rubaiyat are homegrown at the owners' fazenda (cattle ranch), ensuring that the quality is always top-notch. The wine list has an excellent selection of obscure and fantastic Brazilian wines as well as a worldwide range of the usual suspects.
For a quick and fantastic lunch or a great burger head to the Yellow Giraffe. Go Brazilian with the beirute, lending a unique twist to the ordinary cheeseburger by serving it with a pita rather than a bun. This is an adorable little place to enjoy a fantastic selection of salads and sandwiches.
Alex Atala is the preeminent chef of Brazil. This restaurant pulls celebrities and well-heeled couples to its hushed, upscale dining space. Expect Brazilian ingredients with a French twist.
Winner of the 2006 Wallpaper magazine design award for Best Restaurant Concept, ladies could become addicted here. After ordering from the international menu (gazpacho and roasted figs with salad, perhaps?), one can choose from a selection of designer fashion collections to view between courses. Vintage furnishings in the restaurant are also for sale. Fashion and fare in one irresistibly chic place.
The Fasano family has long been known for warm hospitality and mouthwatering Italian cuisine. Located in the hotel of the same name, on a private street, the majestic square space is done up in warm wood and light brown suede. When you call for reservations, ask if they'll have live jazz that night.
Satisfy that craving for sushi in an indoor garden surrounded by fountains and greenery. Along with your favorites, try the baby octopus with curry or the mini wraps with salmon and eel.
With industrial décor and a terrific pizza selection, Piola is considered the most fashionable place to grab a pie. Over 30 pizza combinations to choose from and dozens of fresh ingredients, including Brie and smoked salmon ensure there is something for even the pickiest eaters.
Started in 1989 by Oscar Metsavaht this well known Brazilian has become world renowned in the fashion world with a eye towards leisure and sport clothes. His shops have grown to over 40 with outlets in New York, Milan and Rome just to name a few. This shop is the flagship store.
This shopping emporium is the most glamorous in all of South America. Everything from fashion's top designers to stylish cuisines and cocktails is offered here. Yes, Daslu has it all: you can even purchase a small helicopter here to shuttle you around this ever-expanding capital city. The structure, which is set in a landscaped park, is an architectural destination in itself. The top floor terrace has two gardens; most impressive, however, are the two function rooms that can be converted into cinemas, theatres, catwalks or concert halls at the touch of a button. Add to this the great views and the most knowledgeable, helpful and attractive sales staff anywhere and you can see why we love Sao Paulo.
This cool cluster of shops is where the latest runway fashions from the city's exploding design scene come from. Also check out one of many music shops here: Techno Records and Rhythm Records are the best.
Tucked away in Morumbi Mall, this small boutique is a welcome change. Go there for sequined shoes, sparkly tops and beaded bikinis you won't find elsewhere. You'll certainly be the envy of all your friends when you return home.
If boutique shopping in Sao Paulo has lost its fun, visit the Liberdade Square for some hand made crafts. Hand-dyed silk scarves, wooden spoons and more can be found in this mostly Japanese part of town. Open Sundays 10 am to 7 pm.
This hidden gem is paolista chic embedded in a Rio beach ---a stunning 4 story wood/stone/concrete interior space with a beautiful spiral staircase leading up and down to a sand floored cafe. Caters to the upscale beautiful people of the area. Here you will find a decent selection of tokyo denim and cutting edge brazil, cd's, art-books, odd gadgets. It's just like Paris' Colette, basically --- right down to the iPod listening stations. Very, very luxe.
Exquisitely cut dresses and blouses by the Jil Sander of Brazil.
Excellent travel site for English speakers planning a trip to Brazil, one can find a variety of information, including weather, a forum and English speaking service providers within Sao Paulo.
Fun site to peruse, featuring interesting facts, virtual tours of the city and a wealth of information on galleries, sporting events and cultural happenings.
Brazil's international monthly magazine online.
With one of the largest thriving gay and lesbian communities, Sao Paulo is a great place to find the hottest alternative lifestyle clubs around. This enormous nightclub rivals any in the world with thumping techno beats and different themes every night.
A luxe place to drink and dance with the beautiful people of Sao Paulo. Top DJs and live entertainment can be found here on any given night.
On top of the very modern Unique Hotel, the Skye bar and restaurant is where you might spot artists and actors among the trendy and fabulous. Or just sit back and enjoy the magnificent view of Ibirapuera Park. The bar has an open-air deck and a snazzy red swimming pool. As for music, a resident DJ spins nothing but the hottest around.
In a city filled with so many options for nightlife, Azucar has done it right. The décor looks to have been dreamt up by a gothic Tommy Bahama and the wildly fun Latin music will make you want to put down your mojioto and shake your bonbon.
When established in 1949, the bar was a meeting place for socialites, philosophers, politicians and the like. The décor has maintained its integrity, with authentic pieces and accents, including the original piano that has remained with the bar. These days, the political discussions have been replaced with some of the best live music in Sao Paulo, most notably on Thursday and Sunday.
Gay disco that stays open well past daybreak.
A cavelike, labyrinthine nightclub with a rocking, male-dominated floor.
Looks like a hip spot right out of Manhattan's meatpacking district. Here the difference is both subtle (passion fruit juice in the margaritas) and obvious (the lesbian couple making out next to the gay couple making out next to the straight couple).


Jimmy Page Guitar World Interview in 1998: … I went on tour with the '59 Les Paul that I bought from Joe Walsh, and when I got back … Gibson Les Paul "No. …. the photo and was also likely used for the previous 3 songs on the setlist that night …Jimmy Page's Signature Les Paul … Three separate divisions of Gibson worked there side by side – Artist Relations, … You just have to look at the serial number.