I'm not a big believer in magic bullets. Everything he's ever learned says that you're only as strong as your weakest link. That's why he's always preached that the key to health is raising your entire Baseline of Health. But that said, he admits that what we're talking about here today is a uniquely important anti-aging discovery.
Those numbers are different for each type of cell in our body, and by early adulthood, half of those divisions have been used up. By mid-life, maybe only 20-39% of those divisions are left. At that point, old age starts taking over — then death.
This limited capacity of a cell to perpetuate itself is called the Hayflick Limit. In effect, the Hayflick Limit determines life span at the cellular level. With each division, a cell becomes less likely to divide again, until finally it stops dividing altogether and becomes what we call senescent.
Cell senescence is the final step before cell death. Senescent cells are still alive and metabolically active, but they're no longer capable of dividing. More importantly, though, senescent cells exhibit all the characteristics that so bother us about old age, such as the difference between the supple skin of a child and the wrinkled skin of the elderly.
As cells approach the Hayflick Limit, they divide less frequently and become aberrant. They take on wildly irregular forms. They no longer line up in parallel arrays; they assume a granular appearance and deviate from their normal size and shape. This distorted appearance, called the senescent phenotype, is accompanied by a state of declining functionality that, until recently, was thought to be irreversible.
As it turns out, not only can we now reverse the aging process at the cellular level and do it quite simply and quickly — but we can also reverse aging at the system level and the organ level. And for that matter, we can reverse it in terms of how we look and feel — and by that we mean our skin and hair and energy levels. And then, of course, we can even reverse aging in terms of lifespan.
The nutraceutical I'm talking about is L-carnosine. It's a naturally occurring combination of two amino acids, alanine and histidine, that was discovered in Russia in the early 1900s. Because much of the early research was done in Russia, it was largely unavailable in the United States for decades. Now, though, there have been many studies and experiments in other parts of the world verifying everything done in Russia — and more.
What's probably the most exciting result of the studies is that it was discovered that carnosine can reverse the signs of aging in senescent cells.
When the scientists transferred senescent cells to a culture medium containing carnosine, those cells exhibited a rejuvenated appearance and often an enhanced capacity to divide. When they transferred the cells back to a medium lacking carnosine, the signs of senescence quickly reappeared.
As they switched the cells back and forth several times between the culture media, they consistently observed that the carnosine medium restored the juvenile cell phenotype within days, whereas the standard culture medium brought back the senescent cell phenotype.4 McFarland. Retardation.
In addition, the carnosine medium increased cell life span — even for old cells. When the researchers took old cells that had already gone through 55 divisions and transferred them to the carnosine medium, they survived up to 70 divisions, compared to only 57 to 61 divisions for the cells that were not transferred.
This is mind-boggling. But so far, all we've talked about are cells. What does carnosine mean for actual life expectancy?
In effect, it made the mice look younger. 44% of the carnosine treated mice had young, glossy coats in old age as opposed to only 5% in the untreated mice. This represents 900% better odds of looking young in old age.
Quite simply, carnosine is one of the most powerful antioxidants known. It's a great heavy-metal scavenger. It's a powerful auto-regulator. And it stands alone when it comes to preventing and reversing protein glycation or cross-linking (more on this in a moment).
Carnosine has the remarkable ability to throttle down bodily processes that are in a state of excess, and to ramp up those that are under expressed.
For example, carnosine thins the blood of people whose blood tends to clot too much and increases the clotting tendency in those with a low clotting index.
And carnosine even seems to have the ability to normalize brain wave functions.
Glycation is the uncontrolled reaction of sugars with proteins. It's kind of like what happens to sugars when you heat them and they caramelize. In effect, glycation is what happens when excess sugars caramelize the proteins in your body. It's a major factor in the aging process — and it's particularly devastating to diabetics.
As previously stated, aging is associated with damage to cellular proteins. But carnosine protects cellular proteins from damage in at least two ways.
First, it bonds with the carbonyl (or aldehyde) groups that if left alone will attack and bind with proteins.
Second, it works as an antioxidant to prevent the formation of oxidized sugars, also called Advanced Glycosylation End-products or AGEs for short.9 "Advanced glycation end-product." ScienceDirect. (Accessed 1 Jun 2018.) https://www.sciencedirect.com/topics/medicine-and-dentistry/advanced-glycation-end-product That's really the caramelization thing that we mentioned earlier. In more technical terms, the mechanism by which AGEs induce damage is through a process called cross-linking that causes intracellular damage and cell death.10 Shaikh S, Nicholson LF. "Advanced glycation end products induce in vitro cross-linking of alpha-synuclein and accelerate the process of intracellular inclusion body formation." J Neurosci Res. 2008 Jul;86(9):2071-82. https://www.ncbi.nlm.nih.gov/pubmed/18335520 The bottom line here is that the less AGEs, in your body, the younger you are.
Carnosine has been proven to reduce or completely prevent cell damage caused by beta amyloid, one of the prime protein risk factors for Alzheimer's. The presence of beta amyloid leads to damage of the nerves and arteries of the brain. Carnosine blocks and inactivates beta amyloid. In effect, it protects neural tissues against dementia. The key, as we've already seen, is that carnosine not only prevents damaging cross-links from forming in proteins, it eliminates cross-links that have previously formed in those proteins, thus restoring normal membrane function in cells. This is true not only in the brain, but in all the organs of our body — our skin included. Keep in mind that the damage you see in the skin is not just a cosmetic issue. That damage is absolutely an indicator of the kinds of damage happening to every other organ in your body — including your eyes and your brain.
While it is true that many people who supplement with carnosine are going to notice everything from younger looking skin to more energy, the bottom line is that you really shouldn't look for any short-term benefits from carnosine supplementation. If any short-term benefits are noticed, you should consider them a bonus. The reason you want to supplement with carnosine is for the long-term, not for the short-term benefits that you may or may not notice. You supplement with carnosine to protect against the long-term ravages of aging.
Most recent studies involving carnosine have no direct connection with anti-aging, which is difficult for researchers to quantify. Instead, now that carnosine is considered "real" by the scientific community, the studies tend to be much more specific–and quantifiable–with an emphasis on the role carnosine supplementation can play in reversing things like cardiovascular disease, cancer, and dementia. What makes these studies especially interesting is that although they involve measuring benefits in specific areas of the body, those benefits can easily be extrapolated to the body as a whole, thus serving as confirmation of carnosine's overall anti-aging benefits. Here's a sampling.
Atherosclerotic lesions are also associated with the accumulation of reactive aldehydes formed from the oxidation of fats in the bloodstream. But carnosine helps here too. A study published in 2013 suggests that carnosine inhibits atherogenesis (the formation of arterial plaque) by facilitating aldehyde removal from atherosclerotic lesions.13 Barski OA, Xie Z, Baba SP, Sithu SD, et al. "Dietary carnosine prevents early atherosclerotic lesion formation in apolipoprotein E-null mice." Arterioscler Thromb Vasc Biol. 2013 Jun;33(6):1162-70. http://www.ncbi.nlm.nih.gov/pubmed/23559625 This should not be a surprise as we just discussed that one of the primary benefits of carnosine is that it bonds with carbonyl (or aldehyde) groups that if left alone attack and bind with proteins–thus destroying them. According to this study, deep tissue levels of carnosine may be an important determinant of atherosclerotic lesion formation, and treatment with carnosine could be a useful therapy for the prevention–or the treatment of–atherosclerosis.
So, why is this important to you–assuming you don't have cancer at the moment?
Because cancer and old age are not dissimilar. They both involve the relentless diminishing of cellular DNA, cellular integrity, and ultimately cellular function. The fact that carnosine can protect against this tri-headed assault when your body is confronted by some of the most toxic drugs known attests to its ability to protect against the same kind of assault presented by simple aging.
The authors stated that it is possible, by acting at various sites, that this "pluripotent dipeptide" [their exact words] might be an example of an internally produced "smart drug" [again, their exact words].
And finally, a study published in Andrologia found that carnosine can protect against both the damage and dysfunction caused to cells by exposure to radiation.16 Haeri SA1, Rajabi H, Fazelipour S, Hosseinimehr SJ. "Carnosine mitigates apoptosis and protects testicular seminiferous tubules from gamma-radiation-induced injury in mice." Andrologia. 2013 Nov 12. http://www.ncbi.nlm.nih.gov/pubmed/24215656 Specifically, the study found that carnosine protects against the cellular dysfunction caused by testicular cell exposure to gamma-irradiation, ultimately even restoring the ability of those same cells to produce sperm. That's astounding, as are its implications for carnosine's ability to protect against the cellular dysfunctions associated with simple aging–as well as its ability to restore function where it may have been lost.
Brain damage from reduced blood flow to the brain in infants from about three months before birth to one month after (hypoxia-ischemia brain damage or HIBD) is a major cause of mortality and morbidity in neonates. Currently, there is no effective therapy for HIBD. But studies published in the European Journal of Pharmacology show that carnosine can indeed reduce brain damage in such situations.17 Zhang H, Guo S, Zhang L, Jia L, et al. "Treatment with carnosine reduces hypoxia-ischemia brain damage in a neonatal rat model." Eur J Pharmacol. 2014 Jan 23. pii: S0014-2999(14)00024-7. http://www.ncbi.nlm.nih.gov/pubmed/24463179 Coupled with previous studies that have demonstrated the neuroprotective role carnosine can play when it comes to adult brain damage, it's not hard to see why carnosine supplementation has built a reputation as one of the best things you can do to reduce your chances of succumbing to Alzheimer's disease and dementia.
And a study published in PLoS One found that carnosine's ability to break up alpha-crystallin amyloid fibrils is most likely associated with carnosine's ability to inhibit the amyloid induced cytotoxicity of human neuronal cells, thereby reducing cell deaths in your brain.19 Wu JW, Liu KN, How SC, Chen WA, et al. "Carnosine's Effect on Amyloid Fibril Formation and Induced Cytotoxicity of Lysozyme." PLoS One. 2013 Dec 11;8(12):e81982. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859581/ Amyloid diseases, including hemodialysis amyloidosis, type II diabetes, Parkinson's disease, transmissible spongiform encephalopathies, Huntington's disease, and Alzheimer's disease, are all characterized by the formation of insoluble deposits (aka, amyloid fibrils) in certain tissues and organs. The bottom line is that a constant stream of studies now indicates that if you don't want to take supplemental carnosine to "look" younger and live longer, you will absolutely want to take it to better your odds of avoiding Alzheimer's and a whole host of other amyloid related diseases.
But again, it's not just dementia. An analytical paper published in 2013 indicated that carnosine could play a role in protecting against a range of age related diseases of the nervous system such as Parkinson's.21 Hipkiss AR. "Aging risk factors and Parkinson's disease: contrasting roles of common dietary constituents." Neurobiol Aging. 2013 Dec 4. pii: S0197-4580(13)00616-7. http://www.ncbi.nlm.nih.gov/pubmed/24388766 Keep in mind that aging is a known risk factor for Parkinson's disease. Specifically, there is evidence that indicates that excessive carbohydrate (glucose or fructose) catabolism is a factor in causing the mitochondrial dysfunction seen in Parkinson's. One consequence of this dysfunction is an increased production of methylglyoxal (MG), an advanced glycation end product. But carnosine can not only scavenge MG but can also influence some of the biochemical events (signal transduction, stress protein synthesis, glycation, and toxin generation) associated with Parkinson's pathology.
An article appearing in the Sep-Oct 2013 issue of Advances in Clinical and Experimental Medicine concluded that due to its antioxidant, protective, chelating, and anti-glycation activity, carnosine could be used to prevent and treat diseases such as diabetes, neurodegenerative diseases, diseases of the sense organs, and even cancers.22 Budzen S1, Rymaszewska J. "The biological role of carnosine and its possible applications in medicine." Adv Clin Exp Med. 2013 Sep-Oct;22(5):739-44. http://www.advances.am.wroc.pl/pdf/2013/22/5/739.pdf It may also cure or alleviate many other disorders thanks to its wide spectrum of activity. The authors noted that carnosine is already used by athletes to achieve better results, due to its buffering feature, which contributes to the maintenance of the acid-base balance in the muscles. And they stated that future studies on the influence of carnosine on the human organism may lead to the therapeutic use of this dipeptide for many diseases, in addition to improving both amateur and professional athletes' results.
On a different note, it has been proposed that human blood platelet monoamine oxidase (MAO) activity is a biological marker of vulnerability to a variety of psychiatric diseases. Its activity is significantly inhibited as a result of aging, thus increasing the risk of problems as we age. A study published in the Journal of Physiological Sciences found that this age-induced inhibition of platelet MAO-A activity is reversed in as little as 21 days following the application of sufficient dosages of carnosine.23 Banerjee S1, Poddar MK. "Platelet monoamine oxidase-A activity and aging: effect of carnosine." J Physiol Sci. 2013 Jul;63(4):279-85. http://www.ncbi.nlm.nih.gov/pubmed/23657886 The study concluded that these results suggest that carnosine withdraws the aging-induced inhibition of mammalian blood platelet MAO-A activity and restores its activity towards that observed in young mammalian blood platelets. It seems that carnosine pushes the clock on aging back anywhere and everywhere we look in the body.
Perhaps the best example to end with is another analytical paper published in the Chemistry Central Journal that noted that carnosine has contrasting but beneficial effects on cellular activity.24 Hipkiss AR, Cartwright SP, Bromley C, Gross SR, Bill RM. "Carnosine: can understanding its actions on energy metabolism and protein homeostasis inform its therapeutic potential?" Chem Cent J. 2013 Feb 25;7(1):38. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602167/ As mentioned earlier, carnosine delays cellular senescence and rejuvenates cultured senescent mammalian cells. The paper then went on to explain that studies have now also confirmed that carnosine inhibits the growth of cultured tumor cells as well. Based on studies in several organisms, the authors speculated that carnosine exerts these apparently opposing actions by affecting energy metabolism and/or protein homeostasis (proteostasis). Specific effects on energy metabolism include the dipeptide's influence on cellular ATP concentrations. Carnosine's ability to reduce the formation of altered proteins after exposure to methylglyoxal (see three paragraphs above) and enhance the breakdown of aberrant polypeptides is indicative of its ability to help maintain protein integrity throughout the body.
Some experts recommend using only 50-100 mg of carnosine a day. Others say that if you don't take 1,000-1,500 mg a day it won't work because your body metabolizes the first 500 mg or so.
The older you get, the more you need.
If you eat a mostly vegetarian diet, you need more.
If you're diabetic, or just have trouble with blood sugar, you need more.
Over time, I've found that most people will do best on 500-750 mg a day.
If you're young and healthy and include meat in your diet, then 250 mg a day makes sense. As you get older, and if you're starting to show signs of aging or glycation (such as cataracts or aging skin), then you'd want to think of increasing the dosage up to 1,000 mg a day — maybe even as high as 1,500 mg a day.
In studies, carnosine has been proven safe in amounts as high as 70, 80, or even 100 grams a day, although a small number of people have noticed some minor muscle twitching at doses as small as 1,000 mg. The bottom line is use what you need, and you won't have any problems — only benefits.
As important as carnosine is, there is a "gap" in its usefulness. It's called lipofuscin.
Lipofuscin is the pigment commonly found in aging brains and in other tissue such as the skin (think liver spots). By itself, it is not dangerous. It is merely a byproduct of harmful reactions that have already taken place. For example, one of the byproducts of free radical damage and protein/aldehyde damage (both conditions that carnosine addresses) is lipofuscin.
When you supplement with carnosine, however, something different happens. The carnosine quickly binds with the aldehydes, preventing them from damaging the proteins in your body. The byproduct of this reaction is also lipofuscin. So once again, you have inactive lipofuscin compounds, but this time as the result of PREVENTING protein damage. In a sense, with carnosine, you trade protein damage for lipofuscin.
Again, by itself, lipofuscin is not harmful. However, if enough of it accumulates over time (and this process is accelerated when you supplement with carnosine), it can interfere with proper cellular and organ functions. So, the bottom line is that however it is produced (as a result of protein damage, or as the result of taking sacrificial carnosine to prevent protein damage), you want to minimize it. Which leads us to a discussion of DMAE and Acetyl-L-Carnitine.
By any definition, DMAE is the perfect complement to carnosine in an anti-aging formulation. First, it reinforces carnosine's own anti-aging properties. Then, it provides a whole series of complementary benefits of its own.
Many Baby Boomers have heard of the anti-aging results that Romanian scientist, Ana Aslan, achieved using something called GH3, or procaine. What most people do not know is that GH3 breaks down in the body to form DMAE (after first metabolizing into DEAE) and PABA. In other words, DMAE is the key active component in Ana Aslan's anti-aging formula.
Clinical studies of DMAE have used up to 1,600 mg per day with no reports of side effects. In some cases, some people may experience slight headaches, muscle tension, or insomnia if they take too much too soon.
These effects are easily eliminated if intake is reduced and then gradually increased. Although there is no direct connection, many manufacturers recommend that women who are pregnant or breast-feeding, or anyone who suffers from convulsions, epilepsy, or seizure disorders, and people with manic-depressive illness should avoid using DMAE.
This is probably more of a legal issue than a medical issue.
Like DMAE, acetyl-L-carnitine is a perfect complement to L-carnosine.
Although your body can synthesize L-carnitine in the liver, it depends on outside sources (meat being a primary source) to fulfill its requirements. This can present a problem for vegetarians since L-carnitine performs several key functions in the human body. For one, it can improve the functioning of the immune system by enhancing the ability of macrophages to function as phagocytes. And it can improve the functioning of muscle tissue. In fact, it has been shown to increase running speed when given prior to exercise. It also plays a major factor in cellular energy production by shuttling fatty acids from the main cell body into the mitochondria (the cell's energy factories) so that the fats can be oxidized for energy. Without carnitine, fatty acids cannot easily enter the mitochondria.
ALCAR improves alertness in Alzheimer's patients.
ALCAR enhances the release of dopamine from dopaminergic neurons and improves the binding of dopamine to dopamine receptors.
ALCAR retards the decline in the number of dopamine receptors that occurs as part of the normal aging process and (more rapidly) with the onset of Parkinson's disease. In fact, many researchers believe that Parkinson's may be caused by a deficiency of dopamine.
But most of all, ALCAR just helps slow down the aging process of the brain.
It retards the inevitable decline in the number of nerve growth factor (NGF) receptors that occurs as we age.
ALCAR protects the NMDA (N-methyl-D-aspartate) receptors in the brain from age-related decline.41 Robinson BL, Dumas M, Cuevas E, et al. "Distinct effects of ketamine and acetyl L-carnitine on the dopamine system in zebrafish." Neurotoxicol Teratol. 2016 Mar-Apr;54:52-60. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924529/ NMDA receptor channels play an important role in synaptic plasticity and synapse formation, which underlies memory, learning, and the formation of neural networks during development in the central nervous system.
ALCAR inhibits the excessive release of adrenalin in response to stress and inhibits the depletion of luteinising hormone-releasing hormone and testosterone that occurs as a result of excessive stress.
And ALCAR enhances the function of cytochrome oxidase, an essential enzyme of the Electron Transport System.
A study on L-carnitine has some people worried about using supplements that contain acetyl-l-carnitine. There is no reason to be concerned for a number of reasons.
Based on everything we know, supplementing with a combination of L-carnosine, DMAE, and acetyl-L-carnitine is one of the simplest, most effective, and safest steps you can take to help turn back the clock and optimize your health. For now, it's the closest thing to Ponce De Leon's Fountain of Youth. I've personally been taking my own version of this formula for the last 18 years.
Note: a number of people have been writing in lately asking about using beta alanine to boost carnosine levels to experience carnosine's benefits. And yes, alanine is one of the two peptides, along with histidine, that combine to make up carnosine. And yes, if you supplement with beta alanine, your body will use it to raise carnosine levels in your body. The problem is that it's not very efficient. According to a review of the current literature published in the Jan 2010 issue of Nutrients, you need to supplement with 4.8 to 6.4 grams of beta-alanine a day to significantly increase muscle carnosine levels.47 Julie Y. Culbertson, Richard B. Kreider, Mike Greenwood, and Matthew Cooke. "Effects of Beta-Alanine on Muscle Carnosine and Exercise Performance:A Review of the Current Literature." Nutrients. Jan 2010; 2(1): 75–98. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257613/ Using carnosine supplements is far more efficient.
Very interesting. Is it possible to get a combination of the above molecules in pill form, and from who?
All of Jon Barron's recommended formulas are on the our "Products" page above and it lists who manufactures them, if anyone. For this one, check out his L-Carnosine formula.
I see no product page above or anywhere. I'm interested in the Carnosine product too, but it seems pretty elusive here. Any ideas?
What product page? Theres none!
Am interested. Getting older and its hard to get around.
Please see our comment reply above.
I would like to get the info where to get this product?
Is ACETYL-L-CARNITINE contraindicated in HYPOTHYROIDISM, specifically HASHIMOTO'S disease, or in any other AUTOIMMUNE disease?
Hashimoto's disease can actually cycle between both hypothyroidism and hyperthyroidism. That said, studies indicate that acetyl-l-carnitine can be beneficial in both cases – and specifically for Hashimoto's.
Thank you so much for the information which is very interesting and therefore I am so keen to try it but the problem is: I have no idea what source of foods that will contain carnosine, or where will I obtain the carnosine from so that I can start using it before I can promote the good news to others?
I really look forward to hearing from your side as this is something that sound really helpful and encouraging.
Most of these nutracueticals mentioned here you can find in supplement form. Jon lists some recommended formulas under our "product" page.
What do you recommend for a dozage for someone that is 50 years old of L-carnosine, DMAE, and acetyl-L-carnitine?
what formula do you recommend for a 35 year old female?
Your information about Essential Supplements plus others are indeed excellent and educationally inspirational in every aspects of life maintenance.
Great information about L Carnosine. Just curious about where it is found or extracted prior to its supplement form. Is this a plant-based antioxidant? Thanks.
While it's true that all of the early research on L-Carnosine (in the early 1900's) was carried out using L-Carnosine extracted from cattle, that's not true of supplemental carnosine sold today. The carnosine sold in supplements is manufactured by a fermentation process using friendly bacteria which are fermented in massive vats and then harvested, processed and refined to provide 99.9% pure bio-identical L-Carnosine. The bacteria used for fermenting are a lot like probiotics, so L-Carnosine is vegetarian friendly.
I have been taking carnosine for two months….I consume 500mg per day. The bottle says to take it on an empty stomach….does this mean 20 minutes before food? Or, does it not assimilate into your body if taken WITH food? At 45, and pretty good health, should I take additional Carnosine?
For instructions on the use of the specific product you are taking, you need to contact the manufacturer who produces your product. However, as the article above explains, it's more beneficial to use a carnosine based formula rather than straight carnosine.
Great article, important comments/questions, fabulous and timely response. The responses re-enforced my grasp of the article.
But what exactly to you mean by: "it's more beneficial to use a carnosine based formula rather than straight carnosine." Can one supplement with the three (3) items at the recommended dosage?
Any suggestions for someone (my twin brother) who had dozens of lipomas removed, only to have all the surgical scars turn into keloids (even more unsightly)?
Can you comment on beta-alanine? This converts into l-carnosine and is much cheaper to use. When I use it I initially get a skin itch, similar to niacin flush, but with consistent use the flush goes away.
Should the L-carnosine and the carnitine supplements be spaced away from any particular vitamins or can they be taken together with one's other vitamins?
I want to take L Carnosine for my problem with High Intraocular Pressure (IOP)which will lead to glaucoma as I understand it. I read that L Carnosine should be taken with Alcar which I don't know what that is, because of toxicity? at present I do not have medical coverage and always afraid of trying something that could have side effects and land me in the emergency w/out insurance, can you provide clarification on this? Thank you very much for bringing good news to the world.
Alcar is short for Acetyl-L-Carnitine (ALC). The article above, which was written over a decade ago, is actually the first time that it was ever recommended to take L-carnosine and ALC together. Jon Barron's formula, now sold by Baseline Nutritionals under the name Ever Young, was the first in the world to combine these ingredients. As you obviously read above, it is not because of toxicity, but because ALC complements the action of L-carnosine, and because it helps flush lipofuscin, a byproduct of carnosine's protective action. Unfortunately, over time people have "borrowed" some of Jon Barron's content, but not necessarily his knowledge.
I recently lost quite a bit of weight, and I have noticed that the skin on my throat and around my jaw-line isn't as tight. Would taking L-carsonine help me? I've been taking primrose oil supplements for a few weeks, but I'm wondering if this would work better.
The problem isn't carnosine. It's stretching of fibers.
Up until our 30's, our skin cells work well at replenishing and healing themselves. After that time, diminishing leves of collagen and elastin start to slow things down. Elasticity of the skin depends not only on healthy skin cells, but also on collagen and elastin. These fibers allow the skin to return to its original size after being stretched. Anything that helps the body regenerate collagen and elastin might be helpful.
Carnosine is good, but nothing except resveratrol exhibits the anti-aging effects of RNA/DNA supplements. I've been taking 1-2 grams of it per day since 1988. I'm about to turn 60, but I look 45. I have to show my driver's license constantly to prove my age. I have no wrinkles, no sagging skin, a full head of dark hair, and only need reading glasses. It's a pity so few people know of this remarkable supplement.
PLEASE I NEED TO TAKE THE PRODUCT AND REVERSE MY AGING? HOW TO GET IT? HELP.
How and where do we get the product??? JC.
The link is right above your comment.
I had an eye check up and was told there is the initial start of cataracts forming in both eyes. I am 67 years old and want to avoid future possible surgery. I read that there is also a L-acetyl carnisine liquid product you apply as drops each day to your eyes. The result is that it "dissolves" the early stages of cataracts.
Is this true? Do you also produce and supply this product? If so, would you also have to take a supplement to back up the eye drops? Thanks.
You can search online, or visit Baseline Nutritionals.
I have bleeding internal and external haemorrhoids. Is there anything you can suggest in the way of supplements to remedy this, rather than needing to have surgery ?
Also I have perioral dermatitis is there anything you can suggest for this skin condition. I am a 59 year old female.
Unfortunately, as Jon has also said, as long as we are dependent on food, water, and air to sustain us—and as long as we yell "Ow" when we hit our thumb with a hammer—we are constrained by the laws of the physical universe.
Fantastic article. Well done. I have been on Acetyl L Carnitine, with Alpha Lipoic Acid, for about a year now. It is an AMAZING supplement. I just keep getting younger, stronger and sharper.
Thank you for providing such an in-depth look at what it does.
The problem is not in the carnitine, but in the intestinal flora that process it, and as Jon has stated numerous times before: regular consumption of more than 4 oz of red meat a day dramatically changes the intestinal flora.
I am 38 yr old female with subclinical hypothyroidism but am not on any thyroid medications. Will the carnosine and carnitine have contraindications or benefits for my condition? I have read that carnitine can reduce thyroid hormones(which would be bad for my condition). I do not know anything about carnosine effect on thyroid.
Keep in mind that unless you stop eating all fish, meat, poultry, pork, eggs, dairy, avocado, and fermented soy products, you cannot avoid carnosine and carnitine. In fact, even then, your body synthesizes both. And as far as hyperthyroidism, yes there is some research that indicates carnitine may be beneficial. But that does not mean it is harmful in cases of hypothyroidism. In fact, there are no studies that we are aware of that indicate this is so. As for carnosine, there are no studies that indicate it has any impact on the thyroid.
There is no scientific evidence to suggest that L-carnitine can be used as an alternative treatment for hypothyroidism. However, according the University of Maryland Medical Center, some research studies have indicated a benefit of L-carnitine supplementation for hyperthyroidism.
I have 2 questions regarding carnosine. If I suffer from chronic fatigue, could it help with my energy levels? Also…wouldn't it be more efficient to take a beta-alanine supplement as opposed to carnitine because carnitine is broken down into beta-alanine and histine?
Carnosine is not an energy supplement. As for chronic fatigue, since the exact causes are unknown, it's better to use a Baseline of Health approach, rather than a single supplement approach. In regard to your second question, we assume you're talking about carnosine, not carnitine. Carnosine is formed from beta alanine and histidine, not histine. And yes, you can take beta-alanine, which can be used to create carnosine in the body. But it's not an efficient process. If you want to raise carnosine levels in the blood, supplementing with carnosine is the better way to go.
'When you ingest carnosine intact, most of it is broken down in the gastrointestinal (GI) tract into its constituent amino acids, beta-alanine and histidine. Some intact carnosine does escape the GI tract freely but even that amount is quickly broken down in our blood by the enzyme carnosinase. In a very short time, all the carnosine you just ingested is either eliminated or broken down into beta-alanine and histidine. These two amino acids are then taken into the muscle, where they are converted back into carnosine with the help of the enzyme carnosine synthetase.
The timing of your question is almost perfect as Jon's next newsletter is actually an update on carnosine. That said, your statement that beta alanine is the clearly superior solution to increase carnosine levels is not exactly correct. First, while it is true that carnosinase does indeed break down carnosine, there is not actually that much carnosinase in your body. It only takes a couple of hundred mg of carnosine to overwhelm it. As Jon wrote some years ago.
As for beta alanine, as Jon points out in his upcoming newsletter, it's not very efficient as a carnosine builder. According to a review of the current literature published in the Jan 2010 issue of Nutrients, you need to supplement with 4.8 to 6.4 grams of beta-alanine a day to significantly increase muscle carnosine levels.
The bottom line is that if you take underpowered carnosine supplements, then, yes, beta alanine is superior. But if you take the 500-1500 mg a day supplements that Jon recommends, then no, it is not.
I am 40 age , for maximum benefit, what is the max amount of "Ever Young™" dosage i can take in one day? Whether it is possible to combine " Ever Young™" and "Men's Formula" ? Is it safe in my age ?
Great questions, please contact Baseline Nutritionals for any product related questions. They have a great customer support team.
On the Internet, a lot of stuff about DMAE. In a number of articles on DMAE written that DMAE increases Homocysteine in the body , and DMAE can not be used in diseases of the kidney and liver, is that so?
DMAE is chemically similar to choline. It has two methyl groups, which means it is more likely to lower homocysteine levels than raise it. As for kidney and liver disease, there is no credible evidence that DMAE is problematic. In fact, medical warnings merely say "Maximum safe dosages for young children, pregnant or nursing women, or people with severe liver or kidney disease have not been established. (http://www.med.nyu.edu/content?ChunkIID=21390). Or consult your physician. But that would be true of any supplement if you have severe liver or kidney disease.
The article is a few years old now, not sure if i will get a response. Will it suffice if i take only a combination of DMEA and L-carnosine and if i take it seperately ( seperate supplements) instead of combined in 1 formula. I am 28 years old and healthy with a healthy age management diet. Will i be overdoing with a dosage of 400mg of L-carnosine or does it only add benefit?
You can take them separately, but you do realize that they are already combined, along with acetyl-l-carnitine, in a ready-made formula designed by Jon Barron?https://www.baselinenutritionals.com/products/ever-young.php. Taking two of those capsules a day (one serving) will provide everything you need for a healthy 28 year old. Every five years you can increase that by a capsule a day, until you're doing six capsules a day from your mid-40's on out.
This sentence really makes no sense. What does it mean to improve a person's mood by a percent???
Hi Nick, Not sure about your question. Mood levels can be subjectively quantified just like anything else based on what people respond to in a questionnaire. Right?
I read that carnosine also aids in buffering lactose acid build up, which is why I first looked up carnosine. Is this true?
Is there any possibility of posting the references for this article? I teach a course on Alzheimer's and would like to use this information but I need to be able to quote my sources. If they can't be posted on this web page, any possibility you could e-mail them to me at joan@cancernutritionmatters.com? Many thanks for your kind consideration of this request.
Thank you so much. This is really appreciated.
I have violent reactions to DMAE and procaine family.
can you recommend this formula without DMAE ?
just to guess who might have a formula is guess work.
Missed you so much when you left Healing America. Of course I left also when everything fell apart.
If you already have cataracts, then you might want to take a closer look at the carnosine-based eye drops, which do not contain DMAE. There are several companies that make them.
I started taking acetyl l-carnitine after reading a post about how it could protect the myelin sheath and perhaps even reverse damage to it. Since glossoharyngeal neuralgia may be a result of weakening of the myelin sheath, I thought it might be helpful. I've suffered with this for years, off and on. Soon after I started taking acetyl l-carnitine, I had a new series of pain attacks. Since I couldn't swallow without jabbing pain in my ear, I stopped taking all supplements. My anti-seizure medication had to be dissolved in my mouth to get it in my system. I have since learned that acetyl l-carnitine can exacerbate any seizure disorder and can interfere with anti seizure medication. Please make sure this information gets out to your readers.
Virtually every supplement from a responsible company contains a warning on the label that says something to the effect: Consult your physician if you are pregnant, nursing, taking medication or have a medical condition. Your situation was covered by two of those conditions. You were under a physician's care, and you were taking seizure medication. Check the label on the acetyl l carnitine you purchased and see if the warning is there.
Can Ever Young help with all the spots coming on my body even after years of no sun exposure. I have eaten a lot of sugar in my lifetime and still eat too much. I was wondering if that could be a contributing factor.
Sun spots are not the same as lipofuscin discolorations. Sun spots represent actual damage to the skin. An l-carnosine based formula can help with the lipofuscin, but not so much with the sun spots.
I am 84 years old, Have type 2 diabetes, and high blood pressure (in the 150s-160s). Will this formula (in the article above with the carnosine et al) help with any of these conditions?
Please clarify the following statement made in the description of Carnosine.
How do you get rid of lipofuscin?
One of the prime actions of DMAE is that it flushes accumulated lipofuscin from your body – from the neurons in your brain, from your skin, and from all other organs.
And yes, acetyl-L-carnitine helps flush lipofuscin from the body — especially from the brain.


text:
title: SVG Graph
type: examples
order: 5
---

> This example showcases a combination of custom component, computed property, two-way binding and SVG support.

<iframe width="100%" height="500" src="https://jsfiddle.net/yyx990803/tfpcsxgf/embedded/result,html,js,css" allowfullscreen="allowfullscreen" frameborder="0"></iframe>

redpajama_set_name: RedPajamaGithub


Please enter dates in dd/mm/yyyy format.
HAPPY NEW YEAR TO ALL MY FRIENDS AND FAMILY!
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Share This - HAPPY NEW YEAR TO ALL MY FRIENDS AND FAMILY!
and a prosperous New Year to all my friends and colleagues. T. Martyn.
To all family and friends. Happy Christmas and a Happy New Year. Nancie Goodhart.
to all our friends and family, have a wonderful Christmas and all our love for 2019. Basil and Maggie.
and a joyful New Year to all our family and friends. From the Baxters, Surrey.


You've gathered your tools and setting materials and prepared your floor substrate. It might be tempting to roll up your sleeves and start laying tile. Here's a few things to know before you jump right into installing tile.
Smaller grout lines require less maintenance, and floors are often subject to stains. Keep that in mind when spacing your tile.
When designing your tiled floor, keep the installer – yourself! – in mind. Strive for a layout that maximizes the number of whole tiles and the size of any cut tiles. Doing a dry – adhesive-free – layout will give you an idea of how well your design will work in a particular room.
First, divide the room into quadrants. Snap a chalk line down the middle of the floor's longest side and a second line down the middle of the floor's shortest side, to form a perpendicular intersection. Check the intersection's angles using a framing square.
Before beginning to mortar, dry lay out at least one vertical row and one horizontal row in a quarter – making sure to leave room for grout lines and movement joints.
Movement joints are 1/8 in. to ¼ in. spaces where the tile meets adjacent walls, which you will caulk later. They allow the tile to expand and contract – without cracking – as temperature and moisture levels change.
Grout lines are also important – so important that many small tiles are self-spacing, meaning that they have bumps on their sides that create consistent grout lines between tiles.
If your tiles are not self-spacing, you'll need to use spacers to create grout lines. You can buy tile spacers at Lowe's.
If your layout leaves you with end tiles less than half a tile wide, simply adjust its spacing or vertical centerline. If the problem is unavoidable, arrange your layout so the tile fragments end up in an inconspicuous area.
5. Cut a tile "sandwich"
It is inevitable that you will need to cut some of the tile to cover your entire floor space. To cut the tile, you may need a tile cutter and/or a wet saw. You may be able to rent a wet saw tile cutter at your local Lowe's. A "tile sandwhich" is tile that is correctly cut and positioned, and ready for mortar. Each tile you cut to fit your floor, should be measured and cut individually.
Step 1: To begin cutting your tile, place a loose tile atop the last laid-out full tile. Instead of positioning it directly on top of the tile, however, put it against the wall, corner or edge where the floor stops. Remember to leave room for a movement joint between the tile and wall.
Step 2: Lay a second loose tile over the first. However, align this tile exactly with the last laid-out full tile, instead of placing it against a wall, corner or edge. The loose tile you placed previously should stick out – reaching the wall, corner, or edge – between this tile and the bottom tile. This "tile sandwich" will demonstrate the necessary size of the partial tile. The tile that is the "meat" of this tile sandwich will become the partial tile.
Step 3 Mark the cut line on the "meat" tile, using the second loose tile as a guide. For straight cuts, use a tile cutter. "Polish" the edges with a rubbing brick. Cut openings around pipes, faucet stems, etc. using a power drill with a hole cutter attachment.
Now that you have laid and cut your tiles, the next step is to begin applying mortar. Read on to the next step of our "How to Install Tile Floor Guide" to learn how to do this.
Ron Sheldon is a tile and floor installation guru. He has far too much knowledge on obscure topics like grout and floor leveling. A passionate tile contractor by trade, Ron's spent the past decade dedicated to educating people about tiling, and has great advice on how to perfect your project.


Caroline's Cottage began as a home-based gift basket business in 2014. It was expanded a year later and has quickly become a sought-after spot in its neighborhood retail space. Gift baskets are now only a portion of our overall business. We have well-known, popular gifts as well as unique, hard-to-find items. We'll be glad to discuss a special order, and gift-wrapping is available, too. At Caroline's Cottage, our customers find not only a worthwhile shopping experience in a charming space, but also a positive vibe and friendly, helpful people. Even if you don't have a special occasion coming up, we'd love to have you stop in and browse!
People love to give and receive gift baskets, but many of the choices on the market are mundane and impersonal. Much of the time gift basket contents are predetermined, and choices are limited or just not available. Baskets frequently include items added simply to fill space or to meet a certain price point. Often some of the products are left unused. Our goal is to offer beautiful baskets that are customized to meet the needs of both the giver and the recipient. Our customers have countless options for creating a gift that is just right for their friends, family members, clients and employees.
Gift baskets may be put together with many types of items, but very often include consumables such as coffee and tea, chocolates, baking mixes, and bath and body care products. At Caroline's Cottage, we sell a wonderful selection of food items for our baskets, and we do not carry products made with hydrogenated fats, high fructose corn syrup, or MSG. We only stock what we believe are exceptional bath and body product lines. Careful consideration is given to both your well-being and ours when we select the brands we carry.
If your goal is to give a unique and extra-special gift, come in and talk with us, or just give us a call. We'll be happy to help you create whatever you have in mind.


The governor of North Carolina has appointed Deborah to a judicial seat in the District Court Division. On her weekends, the fledgling judge has been helping an all-woman building crew complete a home for a needy single mother. Her attempts to gain positive P.R. go awry when her niece is found battered and half-naked in the partially completed home, with Deborah's own bloody hammer lying nearby.


I have several problems with a new build using an ASRock Z68 Pro3-m Board.
The processor temperature on the UEFI main screen indicates 30 degrees C or more higher than the temperature reported on the hardware monitor of the ASRock Extreme Tuning Utility.
Changing the SATA mode from IDE to AHCI causes Windows to lock up during booting, after the welcome screen appears. From other posts, it seems like I may need to reinstall Windows after changing to AHCI. Is this correct?
Enabling the Advanced Turbo 50 and using the default settings for the other options causes Windows to lock up, displaying a blue screen and initiating a reboot.
I am using the on-board graphics. The BIOS was upgraded to version1.40.
The first 2 are not problems - the BIOS has no power saving options and is thus running the CPU at full speed.
Second, you need to install windows on AHCI or IDE - you can't interchange between them. You can however change the setting in the registry, reboot, change the setting in the BIOS and then boot up windows and it will work.
Using auto-overclock features is generally frowned upon by overclockers because they don't really work too well.
Thanks for the info. Anybody have success using the Turbo 50 setting? I'm not into overclocking, but will be using this computer for heavy graphics rendering, so I wold like to experiment with the additional speed, without spending a lot of time tweaking.
overclocking sandy bridge K version is not difficult even with manual tweak.
basic tweaking involving adjusting the multiplier (CPU ratio), turbo boost power limit and Vcore. For most sandy bridge K version, using Auto voltage to o/c to around 4GHz should be ok.
of course you should run some testing programs such as Prime95 and RealTemp to check the stability of o/c & temperature, which you should do even using the Turbo 50 setting.
Thanks. Guess I'll have to look into this some more. A whole new opportunity to learn something new. Anybody have suggestions for places / sites / references for us newbies to look?
search 'sandy bridge overclock guide' under google you will get many info. the guides for P67 chipset also works for Z68.
All times are GMT +8. The time now is 08:16 PM.


text:
Week #15 MultiGP Series Global Qualifier Recap
June 29th and 30th two Global Qualifiers were held in efforts to increase the roster and solidify pilot seats for the 2019 MultiGP Championships. The first transpired on Saturday in Fort Worth, Texas with Cowtown Drone Racing while the second transpired Sunday in Muncie, Indiana at the 2019 MultiGP International Open presented by Team Blacksheep.
89 Pilots flew the Global Qualifier Course in either location, with 76 of them achieving the 3-lap minimum to be ranked in either the Pro or Sport Class Division. In total, 38 were ranked for the first time at the event in Indiana, 2 new pilots were ranked in Texas, taking "the List from 399 to 439 Pilots ranked Globally.
While there were pilots running the track for a 2nd or 3rd time, only 50% of the returning pilots bettered their previous times, for a total of 58 pilots being shuffled in or shuffled up the leaderboard.
8 pilots were able to slide into the Sport Class Division (positions 201-300 on "the List") while 2 were able to improve on earlier efforts to remain in Sport Class. Matt "Squawk_1200" Walker went from 282 to 266 with a Fastest-3 Consecutive Lap score of 75.3 in Texas, while Roger "RogerB" Bess improved his time to 80.1 to remain in the division in 292nd. Tom "fireduck" Idland was the newest and highest seed addition to Sport Class with a Fastest-3 Consecutive Laps Score of 66.656 in Indiana to sit 211th on "the List", making him currently the 11th overall seed for the Sport Class Championships, after flying the GQ Track 10 times at International Open.
Of the 39 pilots moving into or up in the Pro Class Division (positions 1-200 on "the List"), 14 of them were personal best efforts after multiple qualifiers, and 25 of them were running the GQ Track for the first official time. Mark "2dogrc" Grohe who was on the bubble last week in 200th, moved up 3 spots with a 65.3-second score to sit in 197th, Joaquin "Jbox" Ybanez climbed from 109th to 37th with a score of 47.1 in Texas and Terry "Beastmode" Arscott ran another personal-best to remain in the top-20 after running the full 10-packs available at IO.
Colby "SFPV" Curtola had the best International Open possible, winning Team Racing with his team Velocidrone-A, winning the Mega Class double-A Main Championship to earn a trip to Korea, finishing 3rd overall in the FAI Team Selection to earn a trip to China, and moved up 5 positions globally to be ranked in the #15 spot on "the List" for an almost guaranteed slot at the 2019 MultiGP Championships. His time was 43.5 (a 14.8, 14.4 and 14.2 on a 3-lap run) for 15th, during one of his 10 packs flown on the GQ Track at IO.
The biggest jump into the Global Qualifying Ranking was by the newly crowned 2-time International Open World Cup Champion Thomas "BMSThomas" Bitmatta (2017 & 2019). He slid into 5th place with a Fastest-3 Consecutive Laps score of 40.98, following a 13.703, 13.784 and 13.493 on laps 4, 5 and 6 on a 6-lap 1:27 run. Officially under timing, BMSthomas only flew it twice out of the ten eligible runs he could have run.
Several other pilots took advantage of the GQ track being set-up at International Open on Sunday: Spanning 69 heats from 10am to 6pm, 82 pilots flew it under official qualifying at least once, 10 flew it twice, 7 flew it three times, 10 flew it four times, 1 flew it 5 times, 7 flew it six times, 10 flew it seven times, 4 flew it 8 times, 4 flew it 9 times, and 24 pilots maxed out at ten packs. Jeff "cyberdrone" Pitoniak and Brent "Drone_Boss" Merrick also flew the maximum 10 qualifying rounds to join the Sport Class in 277th and 269th respectively. Climbing into or up in Pro Class after running the full 10 packs were also: Doug "NashtyFPV" Nash (170th), Guttorm "GutiFPV" Dyregrov (162nd), Ruben "AgentOrange" John (133rd), Joshua "Zstone" Zelmon (112th), Jose "Quino-fpv" Quinonez (110th), Steffen "STM" Melum (101st), Kent "Thumbs17" Beal (98th), Kyle "Twidgit" Buell (84th), Ken "FlyingBear" Loo (68th), Robert "JFK" Lacroix (66th), Bryson "Redfive" Hagerman (64th) and Seth "SethPV" Griggs (48th).
With the 439 Pilots now ranked globally, with the current Sport Class Cut-off being 3 laps in 81.4-seconds (3 x 27-second laps up from 3 x 30-second laps last week), and the Pro Class Cut-off moving to 65.5-seconds (or 21.8 seconds a Lap up from 23.14 last week).
This coming Saturday there are two qualifiers on the Calendar. Rocket City FPV Racing will be hosting their first Global Qualifier in Huntsville, Alabama, and RatRaceFPV will host their second Global Qualifier in Gormley, Ontario, Canada.
See the entire schedule of Global Qualifiers Here – https://www.multigp.com/championships/2019-multigp-series-qualifier-schedule/
And The Global Qualifying Rankings or "The List" here – https://www.multigp.com/championships/2019-multigp-series-global-qualifier-results/
Media, Race Reports

redpajama_set_name: RedPajamaCommonCrawl


text:
Jets fire GM Maccagnan, name HC Gase interim replacement
Alex Chippin
Joe Robbins / Getty Images Sport / Getty
The New York Jets fired general manager Mike Maccagnan on Wednesday and named first-year head coach Adam Gase his interim replacement.
"Mike helped to execute the strategic vision of the organization during the last four seasons and especially the last few months," Jets chairman Christopher Johnson said in a statement. "However, I came to the decision to make a change after much thought and a careful assessment of what would be in the best long-term interests of the New York Jets."
Vice president of player personnel Brian Heimerdinger was also relieved of his duties, league sources told ESPN's Adam Schefter and Jeff Darlington.
The move is a stunner given its timing, as Maccagnan led New York into the NFL draft less than three weeks ago. He and the Jets were active in free agency before that, handing out long-term deals to running back Le'Veon Bell and linebacker C.J. Mosley.
Gase, who was hired in January on the heels of a failed three-year stint as head coach of the Miami Dolphins, will serve as the franchise's leading voice until a new general manager is brought in. Philadelphia Eagles vice president of player personnel Joe Douglas could emerge as a candidate, Schefter suggested.
Rumors of a rift between Maccagnan and Gase floated across New York for weeks, but both were adamant publicly that they shared a healthy working relationship.
Maccagnan made plenty of moves over his four-plus years at the helm, but he'll be most remembered for engineering the trade that helped Gang Green land quarterback Sam Darnold with the third overall pick in the 2018 draft.


text:
Q: Que funcion cumple el 'instanceof'? *Alguien me puede explicar que funcion tiene el instanceof  *
 else if (getParent() instanceof frmEjemplo){ frmEjemplo.setText("texto") }

A: En resumen el operador InstanceOf sirve para saber si una variable es instancia de un tipo de dato.
public static void main(String[] args) {

String nombre = "Programiz";

// verifica si nombre es una instancia de string
boolean respuesta1 = name instanceof String;
//imprime true
System.out.println(respuesta1);

Main obj = new Main();

// verifica si objes una instancia de Main
boolean respuesta2 = obj instanceof Main;
//imprime true
System.out.println(respuesta2);
}

redpajama_set_name: RedPajamaStackExchange


Prenatal Imaging was a traveling exhibition showcasing some of the most famous, most current images of the human embryo. The photography ranged from the famous work of Lennart Nilsson to 3D Ultrasound images. While principally an image exhibition, it also included an opportunity for visitors to use ultrasound themselves by scanning their hand to see the bones inside.


text:
Scopula homaema är en fjärilsart som beskrevs av Louis Beethoven Prout 1920. Scopula homaema ingår i släktet Scopula och familjen mätare. Inga underarter finns listade.

Källor

Mätare
homaema

redpajama_set_name: RedPajamaWikipedia


Published 04/24/2019 01:49:49 pm at 04/24/2019 01:49:49 pm in Feit Electric Shop Light.
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text:
BardBox
Shakespeare and online video
Alas, alas
Posted by: TheGeekyBlonde
Cast: Rhiannon McGavin (narrator, Sockspeare, First Witch, Second Witch, Third Witch, Duncan, Captain, Ross, Macbeth, Banquo, Malcolm, Lady Macbeth, Messenger, Fleance, the Porter, Macduff, Donalbain, First Murderer, Second Murderer, Third Murderer, Lennox, Hecate, Gentlewoman, The Doctor, Siward, Seyton, Young Siward)
Credits: Not given
Among the vast number of Shakespearean videos that now exist, so many of them doing the same thing and seldom very well, it is difficult to stand out – and still more difficult to establish a distinctive style. One filmmaker who has achieved this is Los Angeles-based Rhiannon McGavin, aka The Geeky Blonde. McGavin produces videos on subjects as diverse as poetry and skincare, and her playlist Condensed Shakespeare presents summaries of the plays in an inventive style all of her own.
McGavin's videos give us the essential plot lines, with occasional snippets of Shakespeare's own words. She is the sole performer, cutting between herself as one character and the next (entailing many bargain-basement costume changes, mostly hats), at the same time cutting between the matter in hand and her wry 21st-century perspective on the plays' surface absurdities. The videos simultaneously mock and honour their subject. As each character is introduced there is a comic character description written alongside their name at the foot of the screen. These are videos with their own graphical as well as visual style.
The example here, Macbeth, is typical of the filmmaker's invention. The story is presented as a Hallowe'en treat, with McGavin narrating the story (dressed as the ghost of herself) at the encouragement of her sidekick sock puppet Sockspeare. She then plays twenty-five characters from the play, rapidly cutting from one to the next, all shot in her house and garden in a style that looks charmingly home-made yet clearly involved meticulous preparation and not a little videomaking skill – a model exercise in how to produce Shakespeare out of next to nothing.
McGavin has made similar videos for The Merchant of Venice, Cymbeline, The Winter's Tale, Hamlet, A Midsummer Night's Dream, Twelfth Night, Romeo and Juliet, The Comedy of Errors and Titus Andronicus, between 2011-2013. She does not repeat herself; while keeping to her distinctive style, she plays different variations on the model each time. It is a remarkable piece of sustained invention, auteurist indeed. She performs the Shakespeare that is in her head. It is as though she were reading through the play, with all of the other matters that would be going on in a young 21st Century persona's mind, a mixture of popular culture references (for her YouTube audience to hook on to), puzzlement, delight, and social critique. Shakespeare's plays are an archive of attitudes and assumptions a young woman from Los Angeles in 2012 is unlikely to share. The videos artfully square frustration with admiration, rationalising Shakespeare for a new age and a new audience.
The complete Condensed Shakespeare playlist
YouTube page for Macbeth
Condensed Shakespeare playlist
The Geeky Blonde website
Posted in: Puppets, Shorts and summaries | Tagged: Macbeth
Aaron the Moor
Prospero's Dream
Welcome to BardBox, a selection of the best and most interesting examples of original Shakespeare-related videos available on YouTube and other online sources.
De Niro's Hamlet
Bob Dylan Sings Measure for Measure
Twelfth Grade (or whatever)
Follow BardBox via email
Enter your email address to followBardBox and receive notifications of new posts by email.
BardBox on YouTube
All of the YouTube clips on this site (plus a few more) can also be found on these two playlists on my YouTube channel (user name Urbanora):
BardBox 1
All's Well That Ends Well A Lover's Complaint A Midsummer Night's Dream Antony and Cleopatra As You Like It Cardenio Comedy of Errors Coriolanus Cymbeline Edward III Hamlet Henry IV part 1 Henry IV part 2 Henry V Henry VIII Henry VI part 1 Henry VI part 2 Henry VI part 3 Julius Caesar King John King Lear Love's Labour's Lost Love's Labour's Won Macbeth Measure for Measure Much Ado About Nothing Othello Pericles Richard II Richard III Romeo and Juliet Sir Thomas More Sonnets The Merchant of Venice The Passionate Pilgrim The Phoenix and the Turtle The Rape of Lucrece The Taming of the Shrew The Tempest The Winter's Tale Timon of Athens Titus Andronicus Troilus and Cressida Twelfth Night Two Gentlemen of Verona Venus and Adonis
Audition pieces (3)
Brickfilms (4)
Campaigning films (1)
Comedy sketches (2)
Commentaries (1)
Extracts (1)
Fanvids (1)
Feature films (4)
Impersonations (1)
Machinima (2)
Mashups (10)
Pop music (9)
Prequels (1)
Rehearsals (1)
Shakespeare himself (8)
Shorts and summaries (12)
Silents (6)
Speeches and soliloquies (44)
Stage recordings (3)
Street Shakespeare (8)
Student projects (13)
Uncategorisable (3)
Web series (7)
Bardfilm: The Shakespeare and Film Microblog
Blogging Shakespeare
Shakespeare Geek
The Shakespeare Blog
YouTube Shakespeare
BardfilmKJ
Condensed Shakespeare
Shakespeare on YouTube
Shakespeare's Staging
Stripping Shakespeare
Texas Dallas Bill
The 116 Project
Tim Maloney … the Hamlet of YouTube
International Database of Shakespeare on Film, Television and Radio
MIT Global Shakspeares
Ophelia and Web 2.0
Shakespeare on Screen
Shakespeare Searched
Shakespeare Standard
SHAKSPER
The Hamlet Weblog
The Shakespeare Post
A Labour of Love
Blithe & Bonnie
Bright Summer Night
Jules and Monty
Kate the Cursed
Like, As It Is
Lovely Little Losers
Mac and Beth
Much Ado
Not Much To Do
R & J
The Town's the Thing
Weird Sisters


We are looking forward to hearing from you and filling you in on how to get started with the Boston Podcast Network. Please feel free to get in touch via the form below and we will get back to you as soon as possible. Or contact Kerri Tabasky at kerri@pod617.com; 617.797.2986.


Anyways, after reading The Shining and absorbing all of the Hotel's itching horror, I realized something: my character's were screaming their heads in a flat, boring setting. I put a lot of time into the personalities of my characters only to have them acting on a stage with only a few recycled props. Leave it to Stephen King to show me how much work I still need to do.
So, don't forget that your settings need just as much development as your characters. You want the setting and characters to interact with each other somehow, like we naturally do with our own environment. Give your setting some history and personality. It'll make your story all the more gripping.


I've got a Telecom provided PACE V5542 Router terminating my VDSL connection.
Can anyone recommend a router that will do this for me reliably?
My experience has historically been with a range of static IP's say a /28 range, and then you have the DSL type device as a gateway for the WAN interface and route traffic that way. In this instance, as there is only a Single /32 static IP, i have to have that IP come through to the WAN port on the Fortigate.
Best option is to use the modem solely as a bridge.
Zyxel P870 or Draytek DV130 are the best options.
I use Zyxel or Thompson (Thompson is way overblown for that job though). Work well.


Pool Sessions happening tomorrow (thursday) 5:30pm @ the aquatic center. We have a couple spots and gear still available for people who are interested in learning the fundamentals of whitewater kayaking! This is the perfect first step towards getting out on the rivers around town!
Message the Revelstoke Paddlesport Association via FaceBook or respond to this ad to secure a spot, gear and space limited..


Plan the perfect afternoon tea with our honey cake recipe and Africa's famous rooibos (roy-bos) red bush tea. All you need is a slice of honey cake, a teapot and pretty cups.
Preheat the oven to 350 Fo. In a large mixing bowl, add dried fruit, warm tea, and honey. Mix well, let stand 10 minutes. Beat the egg and whisk it into the tea mixture. Add flour, baking powder and spices beat until well combined. Grease and flour a standard size loaf pan with vegetable oil. Pour the cake mixture into the prepared loaf pan bake 20-25 minutes, or until a skewer inserted into the center comes out clean. Cool and serve with afternoon tea.
Southern Africa rooibos tea is naturally caffeine free.


text:
namespace Diadoc {
namespace Api {
namespace Proto {
namespace Docflow {

namespace {

const ::google::protobuf::Descriptor* ResolutionDocflow_descriptor_ = NULL;
const ::google::protobuf::internal::GeneratedMessageReflection*
  ResolutionDocflow_reflection_ = NULL;

}  // namespace

void protobuf_AssignDesc_Docflow_2fResolutionDocflow_2eproto() {
  protobuf_AddDesc_Docflow_2fResolutionDocflow_2eproto();
  const ::google::protobuf::FileDescriptor* file =
    ::google::protobuf::DescriptorPool::generated_pool()->FindFileByName(
      "Docflow/ResolutionDocflow.proto");
  GOOGLE_CHECK(file != NULL);
  ResolutionDocflow_descriptor_ = file->message_type(0);
  static const int ResolutionDocflow_offsets_[1] = {
  };
  ResolutionDocflow_reflection_ =
    new ::google::protobuf::internal::GeneratedMessageReflection(
      ResolutionDocflow_descriptor_,
      ResolutionDocflow::default_instance_,
      ResolutionDocflow_offsets_,
      GOOGLE_PROTOBUF_GENERATED_MESSAGE_FIELD_OFFSET(ResolutionDocflow, _has_bits_[0]),
      GOOGLE_PROTOBUF_GENERATED_MESSAGE_FIELD_OFFSET(ResolutionDocflow, _unknown_fields_),
      -1,
      ::google::protobuf::DescriptorPool::generated_pool(),
      ::google::protobuf::MessageFactory::generated_factory(),
      sizeof(ResolutionDocflow));
}

namespace {

GOOGLE_PROTOBUF_DECLARE_ONCE(protobuf_AssignDescriptors_once_);
inline void protobuf_AssignDescriptorsOnce() {
  ::google::protobuf::GoogleOnceInit(&protobuf_AssignDescriptors_once_,
                 &protobuf_AssignDesc_Docflow_2fResolutionDocflow_2eproto);
}

void protobuf_RegisterTypes(const ::std::string&) {
  protobuf_AssignDescriptorsOnce();
  ::google::protobuf::MessageFactory::InternalRegisterGeneratedMessage(
    ResolutionDocflow_descriptor_, &ResolutionDocflow::default_instance());
}

}  // namespace

void protobuf_ShutdownFile_Docflow_2fResolutionDocflow_2eproto() {
  delete ResolutionDocflow::default_instance_;
  delete ResolutionDocflow_reflection_;
}

void protobuf_AddDesc_Docflow_2fResolutionDocflow_2eproto() {
  static bool already_here = false;
  if (already_here) return;
  already_here = true;
  GOOGLE_PROTOBUF_VERIFY_VERSION;

  ::Diadoc::Api::Proto::protobuf_AddDesc_Timestamp_2eproto();
  ::Diadoc::Api::Proto::protobuf_AddDesc_ResolutionTarget_2eproto();
  ::Diadoc::Api::Proto::Docflow::protobuf_AddDesc_Docflow_2fAttachment_2eproto();
  ::google::protobuf::DescriptorPool::InternalAddGeneratedFile(
    "\n\037Docflow/ResolutionDocflow.proto\022\030Diado"
    "c.Api.Proto.Docflow\032\017Timestamp.proto\032\026Re"
    "solutionTarget.proto\032\030Docflow/Attachment"
    ".proto\"\023\n\021ResolutionDocflow", 147);
  ::google::protobuf::MessageFactory::InternalRegisterGeneratedFile(
    "Docflow/ResolutionDocflow.proto", &protobuf_RegisterTypes);
  ResolutionDocflow::default_instance_ = new ResolutionDocflow();
  ResolutionDocflow::default_instance_->InitAsDefaultInstance();
  ::google::protobuf::internal::OnShutdown(&protobuf_ShutdownFile_Docflow_2fResolutionDocflow_2eproto);
}

// Force AddDescriptors() to be called at static initialization time.
struct StaticDescriptorInitializer_Docflow_2fResolutionDocflow_2eproto {
  StaticDescriptorInitializer_Docflow_2fResolutionDocflow_2eproto() {
    protobuf_AddDesc_Docflow_2fResolutionDocflow_2eproto();
  }
} static_descriptor_initializer_Docflow_2fResolutionDocflow_2eproto_;

// ===================================================================

#ifndef _MSC_VER
#endif  // !_MSC_VER

ResolutionDocflow::ResolutionDocflow()
  : ::google::protobuf::Message() {
  SharedCtor();
  // @@protoc_insertion_point(constructor:Diadoc.Api.Proto.Docflow.ResolutionDocflow)
}

void ResolutionDocflow::InitAsDefaultInstance() {
}

ResolutionDocflow::ResolutionDocflow(const ResolutionDocflow& from)
  : ::google::protobuf::Message() {
  SharedCtor();
  MergeFrom(from);
  // @@protoc_insertion_point(copy_constructor:Diadoc.Api.Proto.Docflow.ResolutionDocflow)
}

void ResolutionDocflow::SharedCtor() {
  _cached_size_ = 0;
  ::memset(_has_bits_, 0, sizeof(_has_bits_));
}

ResolutionDocflow::~ResolutionDocflow() {
  // @@protoc_insertion_point(destructor:Diadoc.Api.Proto.Docflow.ResolutionDocflow)
  SharedDtor();
}

void ResolutionDocflow::SharedDtor() {
  if (this != default_instance_) {
  }
}

void ResolutionDocflow::SetCachedSize(int size) const {
  GOOGLE_SAFE_CONCURRENT_WRITES_BEGIN();
  _cached_size_ = size;
  GOOGLE_SAFE_CONCURRENT_WRITES_END();
}
const ::google::protobuf::Descriptor* ResolutionDocflow::descriptor() {
  protobuf_AssignDescriptorsOnce();
  return ResolutionDocflow_descriptor_;
}

const ResolutionDocflow& ResolutionDocflow::default_instance() {
  if (default_instance_ == NULL) protobuf_AddDesc_Docflow_2fResolutionDocflow_2eproto();
  return *default_instance_;
}

ResolutionDocflow* ResolutionDocflow::default_instance_ = NULL;

ResolutionDocflow* ResolutionDocflow::New() const {
  return new ResolutionDocflow;
}

void ResolutionDocflow::Clear() {
  ::memset(_has_bits_, 0, sizeof(_has_bits_));
  mutable_unknown_fields()->Clear();
}

bool ResolutionDocflow::MergePartialFromCodedStream(
    ::google::protobuf::io::CodedInputStream* input) {
#define DO_(EXPRESSION) if (!(EXPRESSION)) goto failure
  ::google::protobuf::uint32 tag;
  // @@protoc_insertion_point(parse_start:Diadoc.Api.Proto.Docflow.ResolutionDocflow)
  for (;;) {
    ::std::pair< ::google::protobuf::uint32, bool> p = input->ReadTagWithCutoff(127);
    tag = p.first;
    if (!p.second) goto handle_unusual;
  handle_unusual:
    if (tag == 0 ||
        ::google::protobuf::internal::WireFormatLite::GetTagWireType(tag) ==
        ::google::protobuf::internal::WireFormatLite::WIRETYPE_END_GROUP) {
      goto success;
    }
    DO_(::google::protobuf::internal::WireFormat::SkipField(
          input, tag, mutable_unknown_fields()));
  }
success:
  // @@protoc_insertion_point(parse_success:Diadoc.Api.Proto.Docflow.ResolutionDocflow)
  return true;
failure:
  // @@protoc_insertion_point(parse_failure:Diadoc.Api.Proto.Docflow.ResolutionDocflow)
  return false;
#undef DO_
}

void ResolutionDocflow::SerializeWithCachedSizes(
    ::google::protobuf::io::CodedOutputStream* output) const {
  // @@protoc_insertion_point(serialize_start:Diadoc.Api.Proto.Docflow.ResolutionDocflow)
  if (!unknown_fields().empty()) {
    ::google::protobuf::internal::WireFormat::SerializeUnknownFields(
        unknown_fields(), output);
  }
  // @@protoc_insertion_point(serialize_end:Diadoc.Api.Proto.Docflow.ResolutionDocflow)
}

::google::protobuf::uint8* ResolutionDocflow::SerializeWithCachedSizesToArray(
    ::google::protobuf::uint8* target) const {
  // @@protoc_insertion_point(serialize_to_array_start:Diadoc.Api.Proto.Docflow.ResolutionDocflow)
  if (!unknown_fields().empty()) {
    target = ::google::protobuf::internal::WireFormat::SerializeUnknownFieldsToArray(
        unknown_fields(), target);
  }
  // @@protoc_insertion_point(serialize_to_array_end:Diadoc.Api.Proto.Docflow.ResolutionDocflow)
  return target;
}

int ResolutionDocflow::ByteSize() const {
  int total_size = 0;

  if (!unknown_fields().empty()) {
    total_size +=
      ::google::protobuf::internal::WireFormat::ComputeUnknownFieldsSize(
        unknown_fields());
  }
  GOOGLE_SAFE_CONCURRENT_WRITES_BEGIN();
  _cached_size_ = total_size;
  GOOGLE_SAFE_CONCURRENT_WRITES_END();
  return total_size;
}

void ResolutionDocflow::MergeFrom(const ::google::protobuf::Message& from) {
  GOOGLE_CHECK_NE(&from, this);
  const ResolutionDocflow* source =
    ::google::protobuf::internal::dynamic_cast_if_available<const ResolutionDocflow*>(
      &from);
  if (source == NULL) {
    ::google::protobuf::internal::ReflectionOps::Merge(from, this);
  } else {
    MergeFrom(*source);
  }
}

void ResolutionDocflow::MergeFrom(const ResolutionDocflow& from) {
  GOOGLE_CHECK_NE(&from, this);
  mutable_unknown_fields()->MergeFrom(from.unknown_fields());
}

void ResolutionDocflow::CopyFrom(const ::google::protobuf::Message& from) {
  if (&from == this) return;
  Clear();
  MergeFrom(from);
}

void ResolutionDocflow::CopyFrom(const ResolutionDocflow& from) {
  if (&from == this) return;
  Clear();
  MergeFrom(from);
}

bool ResolutionDocflow::IsInitialized() const {

  return true;
}

void ResolutionDocflow::Swap(ResolutionDocflow* other) {
  if (other != this) {
    _unknown_fields_.Swap(&other->_unknown_fields_);
    std::swap(_cached_size_, other->_cached_size_);
  }
}

::google::protobuf::Metadata ResolutionDocflow::GetMetadata() const {
  protobuf_AssignDescriptorsOnce();
  ::google::protobuf::Metadata metadata;
  metadata.descriptor = ResolutionDocflow_descriptor_;
  metadata.reflection = ResolutionDocflow_reflection_;
  return metadata;
}

// @@protoc_insertion_point(namespace_scope)

}  // namespace Docflow
}  // namespace Proto
}  // namespace Api
}  // namespace Diadoc

// @@protoc_insertion_point(global_scope)


Get Your Rear in Gear and Tour de Tush – Twin Cities, a 5K Run/Walk, Kids' Fun Run and 25-Mile Bike Ride raises funds for colon cancer awareness efforts in the Twin Cities-area. Money raised will stay in our community to encourage screening and education for the nation's No. 2 cancer killer. With your help, we can positively increase screening rates for this highly preventable cancer.


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Apple TV has signed Vince Gilligan and Rhea Seehorn, fresh off Better Call Saul, to two seasons of a new series. (9/22 @ 7:36pm) 🎬 These are the titles of the upcoming episodes of the Futurama reboot: "The Impossible Stream," "Rage Against The Vaccine," "Zapp Gets Cancelled," "The Prince And The Product," "Related To Items You've Viewed," "Children Of (9/4 @ 4:45pm) 🎬 Trick 'r Treat is finally getting a theatrical release this Halloween season! (9/2 @ 7:22pm) 🎬 Rhea Seehorn has earned her first Emmy nod for the role of Kim Wexler on Better Call Saul. (7/12 @ 11:19am) 🎬 Tony Sirico, the actor best known as Paulie on The Sopranos, has died at 79. (7/9 @ 1:05am) 🎬 James Caan, who played Sonny Corleone in The Godfather, among more than ninety other roles in a career spanning seven decades, has passed away at 82. (7/7 @ 11:21am) 🎬 Minions takes out Top Gun and Elvis for the top spot at last weekend's box office. (7/6 @ 7:00pm) 🎬 The Duffer Brothers have formed their own production company, Upside Down Pictures. (7/6 @ 7:00pm) 🎬 Kevin Smith has released the trailer for Clerks 3. It currently sits at #4 on YouTube's list of trending videos. (7/6 @ 7:00pm) 🎬 James Hong, age 93, has become the oldest actor ever to get a star on the Hollywood Walk of Fame. (7/2 @ 6:32pm) 🎬 Joe Turkel, the character actor best known for his role as the bartender in The Shining, has died at the age of 94. (7/1 @ 6:12pm) 🎬 Dune: Part Two will premiere in theaters November 2023. (6/30 @ 1:52pm) 🎬 Original Buzz Lightyear voice Tim Allen offers an opinion on Lightyear (2022): "This is a whole new team that really had nothing to do with the first movies." (6/30 @ 1:49pm) 🎬 Here's the first teaser for Hocus Pocus 2, the long-awaited sequel starring Bettle Midler and Sarah Jessica Parker. (6/30 @ 1:48pm) 🎬 Another Ghostbusters movie is coming. This one will be a direct sequal to Afterlife. It's due out in 2023. (6/30 @ 1:46pm) 🎬 In fan-made trailer for reboot, Frasier goes much darker than its 90s predecessor. (6/30 @ 1:46pm) 🎬 FX and Hulu are bringing The Old Man back for a second season. (6/29 @ 2:10am) 🎬 Marcel the Shell has become the first A24 movie ever to achieve a 100% fresh rating on Rotten Tomatoes. (6/29 @ 1:57am) 🎬 Despite middling responses during its May festival debut, Elvis, starring Tom Hanks and Austin Butler, has achieved an 82% fresh rating on Rotten Tomatoes. (6/23 @ 5:18pm) 🎬 Universal Studios will feature a maze themed to The Black Phone for Halloween Horror Nights 2022 in both Orlando and Hollywood. (6/23 @ 5:14pm) 🎬 The Twilight Zone VR will adapt the classic sci-fi anthology series to VR platforms including Meta Quest 2 and PSVR. Watch the trailer here. (6/23 @ 12:27am) 🎬 As of now, Warner Bros. seems likely not to replace Amber Heard in Aquaman 2. (6/22 @ 7:05pm) 🎬 French actress Lea Seydoux has joined the cast of Dune: Part 2 as Lady Margot. (6/21 @ 2:17pm) 🎬 Knives Out is getting a sequel, entitled Glass Onion - A Knifes Out Mystery. (6/20 @ 1:33am) 🎬 Jurassic World: Dominion holds on to the top spot at the box office, beating out newcomer Lightyear. (6/19 @ 9:18pm) 🎬 Capitol Police arrested a group of Late Show with Stephen Colbert employees while they were filming on location. (6/19 @ 2:28am) 🎬 Ana de Armas will play Marilyn Monroe in Blonde, a Netflix film based on the Joyce Carol Oates novel. Watch the trailer. (6/17 @ 11:50am) 🎬 Bachelor in Paradise's seventh season will premiere on September 27th. (6/16 @ 12:53pm) 🎬 Apparently, this is true: Todd Philips will make the upcoming Joker sequel as a musical, and Lady Gaga is in talks to play Harley Quinn. (6/14 @ 2:20pm) 🎬 Philip Baker Hall, whose six-decade film career included major roles in Boogie Nights, Magnolia, and Argo, has died at 90. (6/13 @ 10:13am) 🎬 Netflix is officially bringing back Squid Game for a second season. (6/12 @ 10:42am) 🎬 Netflix is making another Castelvania animated series. This one's called Castlevania: Nocturne. (6/10 @ 8:47pm) 🎬 What would you like to see more of here at Bingeclock? Let us know! (6/10 @ 8:46pm) 🎬 Amazon has renewed The Boys for a fourth season. (6/10 @ 8:45pm) 🎬 Anthony Hopkins has joined Rebel Moon, directed by Zack Snyder. The Oscar winner will play a robot named Jimmy. (6/9 @ 8:16pm) 🎬 Todd Phillips and Joaquin Phoenix will both return for a sequel to Joker. (6/8 @ 1:17pm) 🎬 Season 5 of Fargo will star Jon Hamm, Jennifer Jason Leigh, and Juno Temple. (6/7 @ 11:18am) 🎬 Rob Zombie says news is forthcoming about The Munsters, a reboot of the classic 1960s sitcom of the same name. (6/7 @ 3:22am) 🎬 Good news, Westworld fans! James Marsden will be back for season 4! (6/6 @ 1:13am) 🎬 Deadpool 3 will retain its crude tone under Disney's oversight, the writers have confirmed. (6/5 @ 12:18am) 🎬
How long does it take to watch every episode of Tia & Tamera?
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Latest News from: University of Pittsburgh Medical Center (UPMC)
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Certain Fat Found Around the Heart Associated with Higher Risk of Heart Disease in Postmenopausal Women
University of Pittsburgh Medical Center (UPMC)
New study points to heart disease risk factor in menopausal women that could be caught early.
Channels: Cardiovascular Health, Heart Disease, Women's Health, Public Health, Staff Picks, Embargoed Feed - hidden, All Journal News,
5-Feb-2017 9:00 AM EST
EXPERT AVAILABLE
Embargo expired:
21-Dec-2016 5:00 PM EST
Reducing the Duration of Antibiotics Does More Harm than Good When Treating Ear Infections in Young Children
In a landmark trial, researchers have demonstrated that when treating children between 9 and 23 months of age with antibiotics for ear infections, a shortened course has worse clinical outcomes without reducing the risk of antibiotic resistance or adverse events.
Channels: Children's Health, Drug Resistance, Healthcare, Hearing, Infectious Diseases, Public Health, NEJM, Staff Picks, Embargoed Feed - hidden, All Journal News,
Bacterial 'Sabotage' Handicaps Ability to Resolve Devastating Lung Inflammation in Cystic Fibrosis
The chronic lung inflammation that is a hallmark of cystic fibrosis, has, for the first time, been linked to a new class of bacterial enzymes that hijack the patient's immune response and prevent the body from calling off runaway inflammation, according to a laboratory investigation led by the University of Pittsburgh School of Medicine.
Channels: Cell Biology, Immunology, Infectious Diseases, Respiratory Diseases and Disorders, Staff Picks, PNAS, Embargoed Feed - hidden, All Journal News,
Keywords: Cystic Fibrosis
12-Dec-2016 10:05 AM EST
22-Nov-2016 11:00 AM EST
Palliative Care Improves Quality of Life, Lessens Symptoms
People living with serious illness who receive palliative care have better quality of life.
Channels: Healthcare, Staff Picks, JAMA, Embargoed Feed - hidden, All Journal News,
18-Nov-2016 12:05 PM EST
International Team Decodes Cellular Death Signals
A multidisciplinary international team of scientists solved the mystery of a recently discovered type of controlled cell death, mapping the path to potential therapies for conditions ranging from radiation injury to cancer. The study, led in part by the University of Pittsburgh, is reported today in two papers in Nature Chemical Biology.
Channels: Cancer, Cell Biology, Chemistry, Staff Picks, Nature (journal), Embargoed Feed - hidden, All Journal News,
Patients with Insomnia Have Altered Activity in Specific Brain Regions
Specific brain regions, including those involved in awareness of self and tendency to ruminate, show altered activity in patients with insomnia when compared to good sleepers, according to a new study by researchers at the University of Pittsburgh School of Medicine published this week in the journal SLEEP.
Channels: Neuro, Sleep, Staff Picks, Local - Pennsylvania, All Journal News,
19-Oct-2016 3:05 PM EDT
Research Links Sleep Habits to Adolescent Drug and Alcohol Use
A study led by researchers from the Department of Psychiatry at the University of Pittsburgh School of Medicine and Pitt Department of Psychology has identified a possible link between adolescent sleep habits and early substance abuse. The study, published today in the journal Drug and Alcohol Dependence, found that both sleep duration and sleep quality during late childhood predict alcohol and cannabis use later in adolescence.
Channels: Alcohol and Alcoholism, Drugs and Drug Abuse, Substance Abuse, Staff Picks, Sleep, All Journal News,
19-Sep-2016 1:05 PM EDT
Watercress Extract Detoxifies Carcinogens in Smokers, Clinical Trial Demonstrates
Watercress extract taken multiple times a day significantly inhibits the activation of a tobacco-derived carcinogen in cigarette smokers, researchers at the University of Pittsburgh Cancer Institute (UPCI), partner with UPMC CancerCenter, demonstrated in a phase II clinical trial presented today at the American Association for Cancer Research (AACR) Annual Meeting in New Orleans.
Channels: Cancer, Health Food, Nutrition, Public Health, Smoking, Staff Picks, Medical Meetings,
Keywords: Watercrest, Smokers, Smoking
20-Apr-2016 1:05 PM EDT
Most Patients Likely to See Reductions in Pain and Disability after Bariatric Surgery; Study Identifies Who Benefits Most
In the three years following bariatric surgery, the majority of patients experienced an improvement in pain and walking ability, as well as a lessening of the degree to which back or leg pain interfered with work, according a University of Pittsburgh Graduate School of Public Health-led analysis of a multi-site clinical study published today (April 5) in the Journal of the American Medical Association.
Channels: Obesity, Pain, Surgery, JAMA, All Journal News,
7-Apr-2016 3:05 PM EDT
New Placenta Model Could Reveal How Birth Defect-Causing Infectious Agents Cross From Mother to Baby
Researchers at the University of Pittsburgh and Magee-Womens Research Institute (MWRI) have devised a cell-based model of the human placenta that could help explain how pathogens that cause birth defects, such as Zika virus, cross from mother to unborn child. The findings were published today in Science Advances.
Channels: OBGYN, Women's Health, Staff Picks, All Journal News,
7-Mar-2016 2:05 PM EST


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Best hotel apps for iPhone: Hotel Tonight, Airbnb, Jetsetter, and more!
The best hotel and rental apps for iPhone to help you snag the best reservation, booking, and all around deal on your next getaway!
Looking for the best iPhone apps for finding great hotels and booking the best reservations? The iPhone can make finding, booking, and paying for a hotel room or rental property simple, but that doesn't mean all booking and reservation apps are created equal. Whether you're traveling for business or looking for a rental property on the beach for a family vacation, the App Store has a lot to offer. But which hotel apps are the very best?
Hotel Tonight is a great app for times when you're in a pinch and need to book a hotel room for that particular night. It takes advantage of hotels that are trying to book rooms so they aren't vacant. This is typically when hotels offer greater discounts since they'd rather fill them then let them sit empty and make nothing. Hotel Tonight is also picky about what hotels they advertise for, which means you shouldn't be disappointed in the hotel you book. Hotel Tonight supports booking for up to 5 nights.
If you're a procrastinator and need a room right now, Hotel Tonight offers some of the best deals for last minute shoppers.
Airbnb isn't a hotel booking app but focuses on rental properties owned by individuals instead. People from around the world put their apartments and rental properties on Airbnb and real people like you and I can book them and leave reviews. Airbnb also verifies a lot of their listings for authenticity so you know the pictures you're seeing aren't photoshopped or edited. You can then leave reviews on properties as well as contact the owners directly with any questions you may have.
If you're planning a getaway and prefer something more cozy and functional than a hotel room, be sure to check out Airbnb.
Jetsetter, like Hotel Tonight, also specializes in last minute deals. For most cities you won't see deals for tonight until after 1pm local time. Jetsetter makes hotels even more affordable by not telling you the actual hotel until you book it, just the general area. Since Jetsetter verifies all of the hotels and properties they partner with, you can rest assured you're getting a decent hotel. You'll just have to take a gamble on which hotel you're getting that night.
If you're willing to task a risk to save some cash, Jetsetter is where it's at.
Hotel Reservations by Booking.com is a more traditional hotel booking app that lets you pick your specific hotel. That doesn't mean there aren't deals to be had though. Hotel Reservations can also tell you how many people have recently viewed a property and how busy hotels are in a specific city is for your chosen nights. You can also watch for secret, late, and value deals to get even more money off your stay.
If you want a more conservative way to find a place to stay, Hotel Reservations by Booking.com is one of the best.
Hipmunk lets you search for both flights and hotels. For hotels Hipmunk provides a more traditional experience but also integrates TripAdvisor reviews so you have two different rating systems in one place. I prefer using Hipmunk over the actual TripAdvisor app since it pulls in the best parts of the service, but leaves the cluttered interface behind.
If you value TripAdvisor reviews but don't like their official app, you want Hipmunk.
Dwellable is simliar to Airbnb and focuses on rental properties owned by individuals rather than commercially owned hotels. You may find some smaller condo complexes that rent but for the most part, you're getting actual homes or condos, not a standard hotel room. Dwellable isn't available in all areas but where it is, you'll be hard pressed not to find something that suits both your taste and your budget.
If you want to book a house or a condo instead of a single hotel room and can't find anything on Airbnb, give Dwellable a try.
Your favorite hotel finding and booking apps for iPhone?
If you've used your iPhone to help you book a hotel or rental property, what app — or apps — did you use? And if you use something else that you think deserves to be on this list, be sure to let me know that too!


After a very successful launch in August last year, our new waterjet cutting division has gone from strengths to strengths and we have recently commisionned our second waterjet cutting machine to accomodate increasing demand.
With a bed size of 4m x 2m and the capability to cut ANY material up to 200mm thickness, this additional Dynamic Waterjet Cutting Machine allows us to provide competitive cutting services to a broad range of industries including oil and gas, nuclear, defence, and marine to name but a few.
A non exhaustive list of material we cut on a daily basis include: Copper, Brass, Bronze, Aluminium, Carbon Steel, Stainless Steel, Iron, Acrylics, Plastics, Carpet, Cork, Foamex, Rubber, Glass, Fibreglass, Carbon Fibre, Wood, Leather, Silicone, Granite, Limestone, Marble, Slate, Ceramics & Composites!
Visit our Waterjet Cutting webpage to learn more!
Our investments in market leading dynamic Waterjet cutting technologies mean that we can offer machined tolerances & quality to the UK's highest standards. We service a broad range of industries including engineering and fabrication, aeropace, defence, nuclear and architectural metalwork.