text:
49ers HUB
Game Week Central
49ers News
Meet the Hub
For the Fans, From the Fans
© 2017 - 49ers Hub
The Relentlessness of Cassius Marsh
Nicholas McGee
Cassius Marsh entered his fifth training camp as an NFL player on Thursday and, did so with an opportunity before him that he has never had in his pro career.
It is Marsh's first San Francisco 49ers training camp, but is also be his first where he has the chance to be a team's leading edge rusher.
He has this opportunity thanks, in large part, to a relentless playing style that helped him catch the eye in a six-game, late-season audition for the 49ers, earning a two-year extension off the back of it after being cut by the New England Patriots.
That the Patriots waived Marsh having traded draft capital for him tells you what they thought of his level of play. However, in May Marsh told The San Francisco Chronicle he had basically asked to be cut because he was unhappy playing coverage instead of being allowed to rush the passer.
Marsh's request provided a great example of his self-belief that, put in the right situation, he can thrive. And he appears to have landed in the right situation with the 49ers, whose defensive coordinator's philosophy marries up with Marsh's demeanor.
Describing Marsh as "relentless", per The Sacramento Bee, defensive coordinator Robert Saleh said of the former Seattle Seahawk: "He's the definition of 'all gas no brakes.'"
Marsh's aversion to the brake pedal was evident on last year's tape, which suggested he could be a solution to a Niners pass rush that had just 30 sacks last year despite DeForest Buckner racking up 52 pressures on the interior, per Pro Football Focus.
His first game as a 49er came against the Seahawks and provided an early indication of his determination. On the play below Marsh keeps himself involved despite seeing his initial pass rush fail, working his way off the block and back up field before laying out to bring down Russell Wilson.
That play had little impact beyond limiting Wilson's gain, yet it did provide some foreshadowing of the effort to come as Marsh impacted a defense that improved down the stretch.
His first sack and forced fumble for the 49ers came a week later in a win over the Chicago Bears but came on a play where he had a free run to Mitchell Trubisky, with the below plays from games with the Houston Texans and Tennessee Titans better examples of the consistent effort Marsh brought to the table.
First he gives outstanding pursuit in keeping Texans quarterback T.J. Yates from picking up possible first-down yardage on the run. On the second play you see Marsh barrel through the blocks of the tight end and the running back to force Marcus Mariota out of the pocket.
His desire to consistently give every ounce of effort on each snap paid dividends in the final game of the season with the Los Angeles Rams, Marsh showing wherewithal to go along with his relentlessness as, despite his rush eventually being slowed down, he leaps to bat the ball away from Sean Mannion as he winds up to throw.
Marsh, though, has more to his game than just effort and, while his bend can be considered inconsistent at best, he does have an inside move at his disposal, using it twice against the Rams to pressure Mannion, the second play the more impressive as he pairs an arm-over move with his hop back to the inside to again give himself a clear path to the quarterback.
His ability to win inside should see him used consistently on stunts, as he was on this play from the Titans game, performing a stunt with Solomon Thomas that was effective in that Marsh's pressure again helped force Mariota from the pocket.
Marsh's main role, though, may be to serve as a sweeper. Sweeper is a soccer term for a player who sits behind the last line of defense and attempts to clear up any looming danger, and for Marsh the job description is not too dissimilar in a pass rush attack unsurprisingly set to be centered around Buckner.
The Niners' new pass-rush specialist Chris Kiffin, per The Sacramento Bee, has spoken about setting a trap for opposing quarterbacks, funnelling them towards Buckner and then attempting to guess which way they will try to run when he penetrates the O-Line, as he did almost at will last year, to ensure the pressure is converted and the threat of them escaping is stopped.
It's a plan built around Buckner, but it also seems like one made for Marsh, whose ability to stay in the play should have a positive impact on the conversion rate of the pressures from the interior.
Marsh's relentlessness did not appear to be appreciated in Seattle or New England but, for the 49ers, it may well just be exactly what they need for their quarterback traps to have success.
You can follow Nicholas on Twitter here!
Stay tuned to 49ersHub for more great content!
Cassius Marsh


text:
Home Celebs Boosie BadAzz thinks R. Kelly's victims exaggerated their abuse allegations, says Kelly...
Boosie BadAzz thinks R. Kelly's victims exaggerated their abuse allegations, says Kelly just likes "young bitches"
Boosie BadAzz believes the victims of convicted sexual abuser R.Kelly are exaggerating the stories of torment and kidnapping they suffered through.
Boosie recently appeared on VladTV, during which he was asked to opine about R. Kelly's conviction on sex trafficking and racketeering charges. The Louisiana rapper seemed to downplay Kelly's actions and was not fully buying the stories of some of the women who were abused at the hands of the disgraced R&B singer for years. "This is how I feel about that. Everything was pushed to another level. You know, I just feel like R. Kelly like the young bitches," said Boosie.
He continued, "All that shit, seducing and kidnapping and all this shit in somebody house, if you leave a bitch at the house and you go on tour for two weeks and she don't go nowhere, that bitch ain't been kidnapped. She waiting on daddy to come home. You know, a bitch ain't been kidnapped. Bitch ain't been sexualized if she been in the bed with three, four women. You know, she hasn't been taken advantage of, because she is willing. She is willing. He just fucked up on the age part…if he did it. I'm not saying he's guilty or if he did do it, it's because of the age. The rest of that shit, they exaggerating, bro."
Back in September, a jury of seven men and five women found the troubled crooner guilty of racketeering and eight violations of sex trafficking charges including bribery, kidnapping, forced labor, sexual exploitation of a child, sexual trafficking across state lines and racketeering involving six victims. He faces 10 years to life in prison. Kelly also faces sex-related charges in Illinois and Minnesota.
"I'm not gonna castrate my boy," Boosie added.
Check out the full interview clip below.
Previous articleReggae Singer Jah Cure Gets Emotional Seeing His Daughter Performed Live
Next article"This is a haram" – Muslims descends on Mo Salah for celebrating Christmas
Cardi B and Cuban Doll Exchange Tweets, Reignite Beef Over Offset's 2018 Cheating Scandal
Flavour admits Shatta Wale's claim that Nigerians are greedy in terms of supporting other...
This 31-Year Old Ghanaian Has Been Arrested In US For Making Child Porn, Faces...
Wilson Eminent - November 17, 2021
I Couldn't Have An Erection For About A Year After My Wife Died –...
Who Are the Taliban and What's Next for Afghanistan?
Wilson Eminent - November 7, 2021

redpajama_set_name: RedPajamaCommonCrawl


Fourth studio album by French electronic music duo Daft Punk. The title, "Random Access Memories" is said to refer to the band's interest in the past. Nile Rodgers of Chic features on three tracks including the single "Get Lucky". The album, featuring the #1 single "Get Lucky", also entered the UK Albums Chart at #1.


text:
Players - Steve Finnan
Birthplace: Limerick, Ireland
Other clubs: Welling United (1993-95), Birmingham City (1995-96), Notts County (1996-98), Fulham (1998-2003), Espanyol (2008-09), Portsmouth (2009-10)
Bought from: Fulham
Signed for LFC: £3.5m, 01.07.2003
International debut: 26.04.2000 vs. Greece
Win ratio: 55.3% W:120 D:52 L:45
Honours: Champions League 2005, European Super Cup 2005, FA Cup 2006
League games / goals / assists: 145 / 1 / 12
Total games / goals / assists: 217 / 1 / 20
After being rejected by Wimbledon at the age of 16 Finnan tried his luck with non-league Welling United, contemplating to working as a bricklayer for his family's building firm if his football career didn't turn out. His dreams came true though when he signed a professional contract with Birmingham City in Football League One in 1995. Finnan didn't stay there long as in March 1996 he was loaned out to Notts County in the third tier of League football where he stayed until the end of the season. He signed for County in October 1996 and played 80 League games in two seasons before transferring to up-and-coming Fulham managed by Kevin Keegan in November 1998. Fulham and Finnan went from strength to strength going up two league levels in three years. Finnan was voted Player of the Year at Fulham in 2002 and received most votes from his fellow professionals in the right-back position in Premiership's best XI 2001/02. He excelled in the 2002 World Cup with Ireland and it was time for him to take another step forward in his career. After 208 games and seven goals with Fulham he joined Houllier's Liverpool in the summer of 2003. Jamie Carragher, whose place was under threat following the Irishman's arrival, tried to be philosophical about it when put on the spot: "There's no point sulking about it," Carra told Sky Sports. "There's not a lot you can do, except impress the manager in training and in games. Or find out Finnan's address and send the boys round!"
Finnan struggled in his first season, but to be fair the 2003/04 season was a lowpoint for many other players and it turned out to be Houllier's last. He improved considerably after Benítez took over and proved to be a model of consistency as he played in 99 of the club's 114 Premier League matches between August 2004 and May 2007. His Spanish boss was very impressed: "Finnan is a player who will always play at a consistent level," Benítez said in 2006. "He will be seven, eight, nine or even ten out of ten every week. Some players find a good level for individual games but don't do the same every week. Finnan does it for a whole season." In 2007/08 Finnan figured in only 35 of Liverpool's 59 competitive matches as Benítez often preferred Arbeloa and Aurelio as his full-back pairing. Towards the end of January 2008 Finnan announced his retirement from international football after being 'capped' for the fiftieth time by the Republic of Ireland. Giovanni Trappatoni managed to bring him back to the Ireland set-up and he returned on 20 August 2008 against Norway, adding three games to his international total before retiring once and for all in September 2008.
The Irishman signed for La Liga side Espanyol on the last day of the August transfer window in the 2008/09 season. Although he had signed a two-year contract, the Spanish club agreed to release him after just a single campaign. On 28 July 2009, the 33-year-old returned to English football with Portsmouth, incidentally replacing Glen Johnson who had moved to Liverpool. Finnan played 21 times for Portsmouth in the Premier League in 2009/10, taking his total of League appearances for five English clubs up to the 450 mark. Pompey had a disastrous League season and comfortably finished in last place, a position they would still have occupied even without a nine-point penalty for going into administration. The club's salvation came in the FA Cup when Finnan unexpectedly found himself playing in the final at Wembley four years after representing Liverpool in the final in Cardiff against West Ham. Finnan's London experience of the final was not as happy as it had been in the Welsh capital, Chelsea winning by one goal to nil. The final was Finnan's last appearance in his professional football career and after spending a few years helping with irrigation projects in Gambia he returned to London, going into property development.
Totals 145 13 6 51 2 217
2004-2005 33 0 5 14 0 52
17 1412 Chelsea
10 820 Portsmouth
10 811 Middlesbrough
10 763 Tottenham
6 543 West Ham United
6 540 Charlton Athletic
6 466 Fulham
4 360 Watford
4 360 Wigan Athletic
3 270 PSV Eindhoven
3 270 Reading
2 180 Maccabi Haifa
2 180 Bordeaux
2 180 TNS
2 180 AS Monaco
2 180 Porto
2 180 Leeds United
2 180 Luton Town
2 180 Norwich City
2 180 Juventus
2 180 Barcelona
2 180 Benfica
2 180 CSKA Sofia
2 178 Marseille
2 175 Olympiacos
2 164 Leverkusen
2 147 Levski Sofia
2 134 AC Milan
2 118 Crystal Palace
2 111 Olimpija
2 99 Toulouse
2 47 Deportivo
1 90 Sao Paolo
1 90 Besiktas
1 90 Havant
1 90 Steaua Bucharest
1 90 Galatasaray
1 90 Real Betis
1 90 FBK Kaunas
1 90 Barnsley
1 90 Anderlecht
1 90 Inter Milan
1 90 Leicester City
1 90 Wolves
1 84 Grazer AK
1 55 CSKA Moscow
1 25 Millwall
Started/substitutions
200 Started
15 On the bench
17 Substitute
18 Substituted
145 Premier League
44 Champions League
6 League Cup
6 UEFA Cup
1 World Club Championship
1 Community Shield
1 European Super Cup
186 Rafa Benítez
31 Gérard Houllier
1 Started
0 Substitute
1 Premier League
Goal minute period
1 31-45 minutes
Assists per season
A more detailed look at the player's assists
3 Tottenham Hotspur
2 Wigan Athletic
2 PSV Eindhoven
1 Levski Sofia
1 Anderlecht
1 Watford
1 Charlton Athletic
1 Luton Town
1 Wolves
1 Fulham
12 Premier League
5 Champions League
1 17.08.2003 Chelsea Anfield League
50 23.11.2004 AS Monaco Stade Louis II Europe
100 19.11.2005 Portsmouth Anfield League
150 28.10.2006 Aston Villa Anfield League
200 28.11.2007 Porto Anfield Europe
1 42 11.09.2004 WBA Anfield League
The Irish Kop
The Irish Kop is a tribute from the heart of Anfield to those amazing fans who go to incredible lengths to follow Liverpool FC.
Unsung Heroes: Steve Finnan
An article on Steve Finnan from squarefootball.net on 13.10.2005.
"I was at Wimbledon when I was 16. I was absolutely gutted to be released because, as everybody knows, at school you set your heart on something and when you are let down it is so disappointing.
"When I then went to Welling I had to think about the possibility of getting another job outside of football. If that hadn't worked out then I would probably have joined the family building firm, working as a brickie or something like that. It is a big leap to be playing in the Champions League final - the biggest game of my career - but after what I've been through to get here, it holds no fears for me."
Finnan in May 2005
"Finnan is a player who will always play at a consistent level. He will be seven, eight, nine or even 10 out of 10 every week. This is really important for the team. Some players find a good level for individual games but don't do the same every week. Finnan does it for a whole season."
Rafa on Finnan in January 2006
"I don't think we've changed anything about how we defend from last season. I think it's just down to time - we've been working with the boss for longer now and I think we now understand what he wants from us better. A year ago, we'd only been with the manager for six months and it takes time to change things at any club. We were used to playing one way before Benitez arrived and now, 18 months on, we're used to his style, his tactics and the way he wants us to play.
The zonal defending system is a good example of how things take time to perfect. I don't think many of the players had played it before because throughout most of our careers we've always gone man-to-man in the box but as soon as Rafa drilled it in to us what to do, I don't think we had many problems adjusting to it. The defence isn't perfect yet but as long as we keep working hard in training and during matches, we should improve further still."
Steve Finnan in December 2005
"I was playing a different role at left-back then [2000-2001], and Markus Babbel was superb as right-back. What I'd say is as brilliant as Markus was that season, Steve Finnan's the best right-back I've played with. He doesn't get a lot of credit, but when the PFA team of the year awards are announced, I'd be amazed if he isn't right-back. Unfortunately, you're not allowed to vote for your team-mates. If you could, he'd be my first pick."
Carra on Finnan in 2005-2006
"Steve has shown a massive improvement over the last eighteen months or so. I can't think of a better right back in the Premiership at the moment. The way he's been playing all season has been outstanding but he's a relatively unsung hero. You only have to look at his performances on a weekly basis to see how good he is now. I always thought Finnan was good on the ball but he's dramatically improved defensively since he's been at Liverpool.
"That defensive improvement also brings the best out of him when he's on the ball because of the confidence factor. If you go back to the start of last season when Carragher was switched to centre half, it looked like right back could be a problem position. Not any more it doesn't. Finnan has got to take all the plaudits for that because sometimes, when people aren't sure about you, it can transmit to a player and they sink. The opposite has happened to Finnan. He's grown in confidence and is now playing better and better and better."
Alan Hansen on Finnan in 2005-2006
"He is a very good player and has been great for the past couple of seasons. He's now Ireland's main right-back by some distance and he's also the best in the Premiership at the moment. He goes about his business very quietly, he doesn't grab the headlines but he does an excellent job on the right side of defence.
"When he first signed for Liverpool, you couldn't help but think, 'is he really that good?' but he is getting better and better. His consistency has been first class and you can't ask for anything more. He's proven to be a very shrewd signing. His attacking play is coming on in leaps and bounds and it is no surprise that he's had so many assists this year. He's set up a lot of important goals. On top of that, he defends really well. He knows when to pass, when to stay on his feet. I'm sure he can improve even further.
In many ways, he's like Phil Neal. He is always steady and gives you 100% every game. He's the type of player every successful side needs."
Ronnie Whelan on Steve Finnan
Welling United 1993-1995 °Conference 41 1 41 1
Birmingham City 1995-1996 England First Division 12 1 16 1
Notts County 1995-1996 England Second Division 17 2 20 2
Birmingham City 1996-1997 England First Division 3 0 3 0
Notts County 1997-1998 England Third Division 44 5 51 6
Fulham 1998-1999 England Second Division 22 2 26 2
Fulham 1999-2000 England First Division 35 2 44 3
Fulham 2001-2002 England Premier League 38 0 47 0
Espanyol 2008-2009 Spain 1 4 0 4 0
Portsmouth 2009-2010 England Premier League 21 0 25 0


Investors who have stood by Tesco (LSE: TSCO) must be despairing right now. It is just one blow after another. The stock is down 53% over five years and 25% over the last 12 months. The last thing investors needed was to get caught up in the latest market sell-off. If China ends up exporting yet more deflation to the West, maintaining grocery sector profit margins could be even harder.
Loyal followers have clung onto Tesco regardless, putting their faith in new boss Dave Lewis engineering a drastic turnaround. I think the best they can hope for that it will retrench into a smaller, leaner operation, by cutting costs, closing stores and shelving expansion plans. Few can reasonably expect it to recover its former dominance.
Tesco nonetheless remains the dominant grocer with a 28.3% market share, according to latest figures from Kantar Worldpanel. That marks a 10-year low, however, down from 28.8% 16 weeks ago. Over the same period, Aldi increased sales by 18% and Lidl 12.8%. That is a brutal growth grab, carved out of the broken hearts of big boys such as Tesco, J Sainsbury and WM Morrison Supermarkets (LSE: MRW). The only way they can fight back is to slash their prices, even harder than in the recent price war, but they remain reluctant to sacrifice their margins to do so. And even if they were, they still couldn't slash prices low enough without slashing service as well, and their customers won't thank them for that either.
Nothing seems to go right for Tesco. Just a few short days ago, it was anticipating a three-way private $6b equity bidding war for its South Korean unit Homeplus. But the bids didn't emerge as anticipated, Asian markets crashed along with the Korean currency, and now Homeplus could be dumped at a reduced price.
Despite these troubles, Tesco still isn't cheap, trading at 22.7 times earnings. Buying it now can only be an act of faith, or madness. With the discounters rampant, and drastic Dave's honeymoon period nearing its end, there could be yet more trouble in store.
Investors in Morrisons have been able to console themselves with a whopping yield, now a beyond stonking 8.15%, but not for much longer. The 2015/16 dividend is set to be cut by as much as 65%, hacking next year's forecast yield back to just 3.7%.
Morrisons' recent sales fell at an even faster pace than Tesco's, down 1.1% in 16 weeks, according to Kantar. Market share is now heading towards single figures at 10.8%, down from 11%. The spring share price recovery has petered out, and the recent decision to back its M Local convenience store outlets is the sign of a company firmly on the back foot.
Growth in its belatedly-launched online operation offers some consolation, and management is working hard to cut costs, pay down debts and invest the savings into price cuts on 1,700 items. This will be a smaller operation in future, and we can only hope that it will be sleeker as well.
Earnings per share are forecast to drop another 9% next year, before rebounding sharply to 20% in 2017, suggesting all is not yet lost. By the end of that year, the yield is forecast to be just 3.4%. Morrison won't be much much of an income stock by then, and it would take a rosy-eyed optimists see it as a growth play either.
Why invest in yesterday's men when there are thrilling new stock opportunities out there?
Motley Fool's head of UK investing has found one such company, which he has named the 1 'under-the-radar' pharmaceutical stock with blockbuster potential.
Harvey Jones has no position in any shares mentioned. The Motley Fool UK owns shares of Tesco. We Fools don't all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors.


The greatly anticipated Pantone Colour of the Year for 2018 has been announced: Ultra Violet!
This dramatic, mysterious shade of purple symbolises creativity and artistic wisdom, making Ultra Violet is the perfect colour to incorporate into your home.
Purple is renowned for its regal connotations, and this particular shade produces a powerful statement that will re-energize your interior décor ready for the year ahead!
For this week's blog, we have created an inspirational mood board, bringing together complementary hues and contrasting colours for you to integrate into your scheme in 2018.
For even more inspiration, take a look at our Pantone Colour of the Year 2018 Pinterest board.


I have Moto G with Bootloader unlocked and I have installed TWRP Recovery and I was using CM-12 Nightly Build.
The device was working fine but now The device just Blackouts after reboot and I am unable to access any control of device but when I press Power button for couple of seconds, it shows Reboot/power off/Airplane mode option.
I am able to hear caller ringtones and everything seems to be working fine except the screen is completely black.
I just switched off my phone and then reboot in Fastboot Mode using Power + Volume Down key and then chosen recovery.
This will take some time and the phone will reboot and now it's working fine.
Note : Take backup of data before formatting, you can take backup by connecting phone to your PC via USB and Copying all data on PC.
Not the answer you're looking for? Browse other questions tagged cyanogenmod motorola-moto-g or ask your own question.
My Moto G (2014) stuck on a boot loop while plugged and now doesnt even boot to recovery while unplugged. Any solution?


When I was at a job training, the task was to write down a list of what we want. The head of the branch provided his own personal examples: a nice house, a boat, a even bigger boat… you get the idea.
However, I was simply stuck.
What I want most are things that cannot be guaranteed.
What I want most are things that cannot be bought.
What I want most are things that most people take for granted.
For those with mood disorders, there can always be an underlying anxiety about the disorder, even when at baseline. How long will this sense of normalcy last? When will the crippling anxiety, devastating depression, or chaotic mania come sneaking back in and take complete control? Am I feeling sad, or am I slipping into a depressive episode? Am I happy, or am I verging on manic? I want to live without these symptoms or full episodes, but I don't know if I will.
I want to be able to speak out about being ill without fear of backlash or the impacts of stigma. If I really cannot function at work, am I allowed to take a "mental health day" or will I be called lazy/not taken seriously for doing so? When will my mental illness be taken with the same level of seriousness as physical illnesses?
Do you know how it feels to not be safe in one's own body? Do you know how frightening it can be to not be able to trust your own perception of reality? It can be beyond terrifying. Episodes in the past have led to dangerous situations or states of mind. I want to feel safe, free from the dark grip of bipolar disorder.
Lastly, I want others with mood disorders to feel less alone, especially during this challenging time of year.
You have an army of mental health warriors supporting you in your journey to wellness.


This is a pair of Early American Prescut oval bowls.
They were made by Anchor Hocking Glass Co. They are in good condition with no damage. They would be for bread, crackers, vegitables just all kinds of things. They are so pretty!


With DSL Internet Service Providers in Essex you can get the lowest prices from DSL providers in Essex, MA. Use our DSL Internet Service Providers quote tool to shop all the major DSL Internet Service Providers in the City of Essex.
You can also give us a call at (888) 765-8301 and a Essex DSL Internet Service Providers specialist can assist you with your request!
Receive real-time unbiased Essex DSL Internet Service Providers prices from dsl.internetserviceprovidersisp.com.
Select the Essex, MA DSL Internet Service Providers price plans that interest you.
A Essex, DSL Internet Service Providers consultant will contact you to discuss the details of the Essex DSL Internet Service Providers, confirm pricing, and assist you with the signup process.


text:
Two SLA soldiers killed in ambush
Two Sri Lanka Army (SLA) soldiers were killed and another wounded in an ambush by the Liberation Tigers at Gonawela in Uhane police Division, in the south-eastern Ampara District, around 8.15 a.m. this morning, security sources said.
The wounded soldier has been rushed to the Ampara hospital.
SLA sources said the attack was repulsed. The troops cordoned off and conducted a search operation in the area, the sources said.


text:
Towards the Implementation of QbD to the Production of Therapeutic Monoclonal Antibodies with Desired Glycosylation Patterns
Monday, October 17, 2011: 5:25 PM
M100 I (Minneapolis Convention Center)
Ioscani Jimenez del Val and Cleo Kontoravdi, Chemical Engineering and Chemical Technology, Imperial College London, London, United Kingdom
The US FDA and the European Medicines Agency have recently proposed the implementation of the Quality by Design (QbD) paradigm to the manufacture of biopharmaceuticals. Its implementation requires the use of all available knowledge of a given product, including the parameters that affect its quality, for the design, optimization and control of the manufacturing process. The goal is to ensure that quality is built into the product at every stage of the manufacturing process. Most licensed monoclonal antibodies (mAbs) are based on the immunoglobulin G isotype and contain a consensus N-linked glycosylation site on the Cg2 domains of their heavy chains. Studies have found that the oligosaccharides attached to this site dramatically influence the efficacy of mAbs as therapeutics either by reducing their serum half-life or by directly affecting the mechanisms they trigger in vivo, thus defining glycosylation as a critical quality attribute of mAbs under the QbD scope. It has been recently proposed that detailed mathematical models will play a critical role in the design, control and optimization of biopharmaceutical manufacturing processes under the QbD scope. To our knowledge, there are currently no mathematical models that relate mAb glycosylation with cell culture conditions.
Several reports have shown that glycosylation is directly affected by the intracellular availability of nucleotide sugar donors (NSDs), which are the co-substrates for the glycosylation reactions that occur in the Golgi apparatus. During culture, cells synthesize all the relevant NSDs from glucose through the nucleotide sugar metabolic pathway. In an effort to relate process conditions with mAb glycosylation, we have generated a dynamic mathematical model for this metabolic pathway. The kinetic model was reduced based on the methodology described by Nolan and Lee (Methods in Bioengineering: Systems Analysis of Biological Networks, 2009). In order to estimate the unknown parameters of the reduced model, the intracellular concentration of glucose and eight NSDs was monitored through the course of a batch culture of CHO cells. The cells were harvested and their metabolism quenched. The cells were subsequently lysed and their contents lyophilized for analysis. The intracellular glucose concentration was determined using a fluorescence-based assay kit and the intracellular NSD concentrations were determined with an ion-pairing reverse-phase liquid chromatographic technique. Finally, a series of fed-batch cell culture experiments were performed in order to validate the reduced model and assess confidence in the estimated parameters.
Our mathematical model for NSD metabolism was then coupled to a model for mAb N-linked glycosylation in the Golgi apparatus to generate a direct link between extracellular glucose concentration, which is a readily measurable process variable, and protein glycosylation. The model for mAb glycosylation approximates the Golgi apparatus to a plug flow reactor so that cisternal maturation is represented. Recycling of Golgi-resident proteins (glycosylation enzymes and transport proteins) was also considered. The rate expressions for glycosylation reactions were derived based on their reported kinetic mechanisms and transport of nucleotide sugar donors from the cytosol to the Golgi lumen was modelled to serve as a link between glycosylation and cellular metabolism. Optimization-based methodologies were developed for estimating enzyme and transport protein concentration profiles. The resulting model is capable of reproducing glycosylation profiles of commercial mAbs. It can further reproduce the effect gene silencing of the FucT glycosylation enzyme and cytosolic nucleotide sugar donor depletion have on the mAb oligosaccharide profile.
Such a combined model has great potential for the design, control and optimization of manufacturing processes that produce mAbs with built in glycosylation-associated quality as proposed under the QbD paradigm.
See more of this Session: Advances In Cell Culture II : Metabolic Flux Analysis and Modeling of CHO Cells


text:
Joint BSPGHAN/GUTS UK Research Awards 2019
Guts UK - BSPGHAN Small Grant Round 2021
One small grant up to £10,000 for research on pancreatitis and pancreatic diseases.
Applications are open and will close at 17:00 on Monday 16th August 2021.
For updates please refer to this web-page or email research@gutscharity.org.uk.
Due to Covid-19 pandemic at the moment we are accepting electronic signatures. However, after the deadline, we might ask you to post a wet-signed copy to Research Awards, Guts UK, 3 St Andrews Place, London NW1 4LB.
Full details can be seen via website https://gutscharity.org.uk/research/grants-and-awards/guts-uk-bspghan-grants-2/
Guts UK - BSPGHAN Grant: One development grant up to £40,000 for research on paediatric gastrointestinal, hepatological and nutritional disorders.
Applications are closed.Successful applicants will be notified shortly
Full details can be seen via website Full details can be seen via website https://gutscharity.org.uk/research/grants-and-awards/guts-uk-bspghan-grants-2/
Guts UK-BSPGHAN Grant Round 2019 - Successful applications
Dr Paul Henderson (IBD)
Institution: University of Edinburgh
Title: The PINPOINT study -The Prospective Incidence of Paediatric-Onset Inflammatory bowel disease in the United Kingdom
Project Start Date: 1 October 2019 Completion Date: 31 December 2020
Professor Matthias Zilbauer (IBD)
Institution: University of Cambridge
Title: Stratification of inflammatory bowel disease treatment in children using human intestinal organoid derived epigenetic signatures
Project Start Date: 1 October 2019 Completion Date: 30 September 2020
Previous BSPGHAN and Guts UK (previously Core) Awards 2017
BSPGHAN and Guts (previously Core) https://gutscharity.org.uk/ co-funded a scheme to support the collection of pilot or proof-of-concept data that will enable a high-quality competitive application to be made subsequently to a research council or other large funder.
Stephen Allen, Julian Thomas, Simon Murch and Sarah Moule from the Research Working Group joined colleagues from CORE to assess the research submissions. We were impressed by the high standard of all proposals and breadth of topics covered. All proposals were scored individually in advance of the panel meeting and five were selected for detailed review.
The following two projects were supported:
Chris Probert, Professor of Gastroenterology; Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool.
"Characterization of the gut mycobiome in an inception cohort of paediatric inflammatory bowel disease"
https://gutscharity.org.uk/research/current-active-research/professor-chris-probert/
Sarah Ennis, Professor of Genomics, Genomic Informatics Group Lead, University Hospital Southampton.
"Metabolo-genomic interactions in paediatric Crohn's Diease"
https://gutscharity.org.uk/research/current-active-research/professor-sarah-ennis/
We look forward to receiving feedback as these projects progress. More information about Guts UK is available from https://gutscharity.org.uk/
BSPGHAN/CORE Awards 2015
Stephen Allen and Julian Thomas joined colleagues from CORE to assess 7 submitted proposals. The proposals were of a high standard and were discussed in detail and scored individually by each member of the panel. Although the original budget was £80,000 (with equal contributions from BSPGHAN and CORE), the proposals were considered to be of sufficient quality to include an underspend from a previous award. As a result, a total of £105,987 was awarded to the following 3 successful applicants (with details available from the CORE website):
Dr Emer Fitzpatrick King's College London
"LiverMultiScanTM for the assessment of graft fibrosis in children post-liver transplant"
Prof David Wilson Child Life and Health, University of Edinburgh; Paediatric Gastroenterology, Royal Hospital for Sick Children, Edinburgh
"Health informatics research in paediatric gastroenterology: nationwide data-linkage exploration of perinatal risk factors for and consequences of paediatric-onset Inflammatory Bowel Disease"
Dr Gordon Moran Nottingham Digestive Diseases Centre, University of Nottingham
"Anabolic resistance and abnormal muscle function across the nutritional spectrum: a pilot study in Crohn's disease and non-alcoholic fatty-liver disease"


Traditional farms that are managed from generation to generation by promoting environmentally friendly cultivation without using add..
Increasing sustainable cultivation results according to..
The economic improvement of pond communities is very important to continue environmentally fr..
PT. Alter Trade Indonesia actively participated on the fifth Our Ocean Conference in Bali on 2..
PT. Alter Trade Indonesia once again fosters car..
The Employee Health Examination Program takes place every year as part of government regulation to monitor the health conditions of e..
Commemorating the 73rd Independence Day of the Republic of Indonesia, the big family of PT. Alter Trade Indonesia organizes various ..


text:
Q: angularjs - push new object(as scope) to my list(in services) How to push new object in my array list where my list is in services?
In my controller I have functions that push new layer of object to my list, but since I moved my list array to new file as service. it wont work anymore.
Controller:
$scope.addContact = function () {
        $scope.person.contact.push({
            contactType: "",
            contactNumber: ""
        });
    };

Services:
angular
    .module("person")
    .service("InitService", initializeItem);

function initializeItem() {

    var self = this;

    self.ReturnInit = function () {
        var person = {
            firstname: "",
            lastname: "",
            address: [
                {
                    addresstype: "",
                    addresslocation: ""
                }
            ],
            contact: [
                {
                    contacttype: "",
                    contactnumber: ""
                }
            ]
        };

        return person;

    };

};

everytime I "addContact" it will ".push" new object to my list.
Looking for this:
person = {
        firstname: "",
        lastname: "",
        address: [
            {
                addresstype: "",
                addresslocation: ""
            },{
                addresstype: "",
                addresslocation: ""
            }
        ],
        contact: [
            {
                contacttype: "",
                contactnumber: ""
            }
        ]

A: You can move person var to upper level of your service and then use it like this.
Service:
angular
    .module("person")
    .service("InitService", initializeItem);

function initializeItem() {

    var self = this;
    var person = {
        firstname: "",
        lastname: "",
        address: [{
            addresstype: "",
            addresslocation: ""
        }],
        contact: [{
            contacttype: "",
            contactnumber: ""
        }]
    };

    self.ReturnInit = function() {
        return person;

    };
    self.addContact = function(contact) {
        person.contact.push(contact);
    }
};

Controller:
$scope.addContact = function() {
    InitService.addContact({
        contactType: "",
        contactNumber: ""
    });
};

A: In your controller, $scope.person will reference the object returned by InitService
$scope.person = InitService.ReturnInit();
$scope.addContact = function () {
        $scope.person.contact.push({
            contactType: "",
            contactNumber: ""
        });
    };

redpajama_set_name: RedPajamaStackExchange


Barre will teach this class again in Spring 2018 at the Glasscock School. We asked her a few questions about the course and this front-and-center topic in contemporary American life.
What is a comparative ethicist?
The easiest way to answer this question is to say that comparative ethicists study the similarities and differences between the moral arguments humans make.
What does your research focus on and do you consider the focus to be timely in terms of current political, moral and policy discussions swirling in the US today?
My work compares arguments about the consequences of moral disagreement. If we disagree about morality, how should we make decisions about the law? What are our obligations to fellow citizens who disagree with us? Many political philosophers believe the institutions and norms of liberal democracy should guide our behavior on both fronts, and they are confident we can achieve an "overlapping consensus" about this among all "reasonable" people. My work explores whether this confidence is warranted by comparing the arguments of liberal political philosophers to the arguments of Catholics and Muslims who have constructed parallel responses to the problem of moral disagreement.
Part of what is so unnerving about the current political environment is that we are not simply disagreeing about policy; we often find ourselves disagreeing about the basic norms of liberal democracy itself. And as a result, we find ourselves far more perplexed about how we should respond to those who disagree with us than we have been in the recent past.
Part of what is so unnerving about the current political environment is that we are not simply disagreeing about policy; we often find ourselves disagreeing about the basic norms of liberal democracy itself. And as a result, we find ourselves far more perplexed about how we should respond to those who disagree with us than we have been in the recent past. We understand what liberal democracy demands of citizens who disagree about tax policy. But what of citizens who disagree about whether we must respect one another as equals?
By highlighting the fragility of any overlapping consensus we have secured, my work shows that the deep moral disagreements we face today are not historical anomalies. At the same time, it provides a way forward, pointing to the significance of how citizens respond to such disagreements as the foundation of any future consensus we might achieve.
What motivated you to teach the GSCS course?
Cathy Maris in Continuing Studies was eager to offer a course related to the current political climate, so when she learned of the course I was teaching Rice undergraduates in the fall of 2016, she asked me to offer a version for the wider community through the Glasscock School. I was eager to sign on, as I hoped (and still hope) that helping others think about what democratic citizenship requires of them might, in some small way, contribute to the rebuilding of our public political culture.
What was the key difference between this audience and the undergraduate classroom?
I think the life experience of these students made a difference for the conversations we could have. Students in the GSCS class were current or former federal employees, educators, artists, scientists, parents, and grandparents. They came from all over the world and arrived with a variety of political perspectives. This diversity allowed me to sustain conversations that moved in multiple directions and extended well beyond the core material. My undergraduate students had important intuitions about all of the issues we discussed, but given that most had had relatively similar life experiences up to that point, they were ironically less likely to disagree with one another, or with me.
Students in the GSCS class were current or former federal employees, educators, artists, scientists, parents, and grandparents. They came from all over the world and arrived with a variety of political perspectives. This diversity allowed me to sustain conversations that moved in multiple directions and extended well beyond the core material.
What is meant by the "psychological, anthropological and philosophical accounts of disagreement" that you taught in this class?
The "accounts" I was referencing there are explanations of disagreement that were developed within the context of each of those disciplines. Though disagreement is a central concern of all three disciplines, the theories that are developed in each are rarely integrated. In my mind, we can't arrive at an informed judgment about how we should respond to disagreement until we understand the insights of all three disciplines.
As private citizens, how should we respond to disagreement?
If this question had an easy answer, I wouldn't need to offer an entire course about it! All I can really say is: it's complicated. Much depends on the nature of the disagreement and the goals of our response. Do we disagree about values, about whether climate change is real, or whether 2+2=4? Do we want our response to sustain relationships, advance justice, or move us toward truth? The social sciences can give us some important insight into which responses will be most effective in which contexts, but is that all that matters? Is it OK to use what we've learned from psychology to "win" a debate? Or do we have additional moral obligations to respect the agency of fellow citizens, engaging them as equals in conversation?
What was an example of the insights you offered on "conducting effective, respectful disagreement"?
For starters, our conversations could be significantly improved if we all recognized that moral truth is not self-evident. That is not to say that moral truth does not exist, or that it can't be discovered. The point is simply that such discovery is hard work. As a result, we should expect moral disagreement, be less certain of our moral positions in the face of such disagreement, and engage with others with a willingness to learn together through mutual critique. There is nothing wrong with trying to convince or educate our conversation partners about what we believe. But how often are we equally open to being convinced or educated ourselves?
There is nothing wrong with trying to convince or educate our conversation partners about what we believe. But how often are we equally open to being convinced or educated ourselves?
Is the public hungry for this kind of information?
My sense is that most of us, whatever our views about specific policy matters, are worried about recent changes in our public political culture. This includes our increasing polarization, decreasing support for the institutions of liberal democracy, and a near complete collapse of political discourse that starts with the premise that we should offer all fellow citizens fair terms of cooperation. So, yes, I think we're all hungry for these conversations.


Do Kazakhs prefer goat polo (kokpar) or soccer?
Nauruz is a spring festival celebrated across Central Asia, often with multi-day parties in smaller towns, and concerts and state-organized festivals in larger cities.
And due to the generous guidance of a local friend, my sister and I got to explore the festivities in Kazakhstan's capital city, Astana, for a few hours. Below is a short video set to the tune of singer Yerden's Omir Koktem. I hope it gives you a glimpse of the big-city celebrations!


text:
Q: how can i get functionality like show/hide buttons in Android gallery on screen tap In first image if you tap on screen than android gallery hide the all buttons as shown in second image while on again touch the screen you will find that all buttons re appear again.  Note: On Zooming in-out,on Double tap or moving finger on image of galley don't effect the state it effect only when user tap on screen i want functionality like this. Please help me how can i implement such type of functionality to my Android app

please help me to solve it i had tried onTouchEvent etc with MotionEvent.ACTION_DOWN but it work every time when zoom in-out means every time when i tap on screen it workswhile ondouble tap or move finger on screen.

A: you can use 'GestureDetector' instead of ACTION_DOWN. Example,
 GestureDetector gestureDetector = new GestureDetector(this, new GestureDetector.SimpleOnGestureListener() {

        @Override
        public boolean onSingleTapUp(MotionEvent e) {
            //------------------apply your logic here------------
            return super.onSingleTapUp(e);
        }

        @Override
        public boolean onSingleTapConfirmed(MotionEvent e) {
            return super.onSingleTapConfirmed(e);
        }
    });

and pass touch event to gesture.
@Override
public boolean onTouchEvent(MotionEvent event) {
    gestureDetector.onTouchEvent(event);
    return super.onTouchEvent(event);
}

Edited
After watching comment,
now issue is onTouchEvent not called if pdfviewer attached => This haapen because pdfviewer already consumed touch event.
So you need to use dispatchTouchEvent instead of that. check here
@Override
public boolean dispatchTouchEvent(MotionEvent event) {
    gestureDetector.onTouchEvent(event);
    return super.dispatchTouchEvent(event);
}


text:
Ronald L. Numbers (* 3. Juni 1942) ist Hilldale und William Coleman Professor of the History of Science and Medicine an der University of Wisconsin in Madison. Er lebt mit seiner Frau Janet S. Numbers und seiner Tochter Lesley in Madison, Wisconsin.

Akademischer Werdegang
Ronald L. Numbers hat an der Southern Adventist University in Tennessee Mathematik und Physik studiert. An der University of Florida hat er ein Studium der Geschichte mit einem M.A. abgeschlossen und promovierte an der University of California, Berkeley über ein wissenschaftshistorisches Thema. Als Josiah Macy Fellow verbrachte er ein Jahr am Institute of the History of Medicine an der Johns Hopkins University, darüber hinaus verbrachte er ein Jahr als Fellow des "Interdisciplinary Studies Program" an einem Institut der Menninger Foundation in Topeka, Kansas. Seit 1974 lehrt er Wissenschafts- und Medizingeschichte an der University of Wisconsin in Madison, Wisconsin. Er ist dort "William Coleman Professor" of the History of Science and Medicine.

Er war Mitglied in den Vorständen der amerikanischen Gesellschaft für Medizingeschichte, der Gesellschaft für Wissenschaftsgeschichte und der amerikanischen Gesellschaft für Kirchengeschichte. In der Zeit von 1989 bis 1993 war er Herausgeber der Zeitschrift Isis, dem Organ der Amerikanischen Gesellschaft für Wissenschaftsgeschichte. Er arbeitet derzeit an dem Artikel "Amerikanische Wissenschaftsgeschichte" für das Lexikon der "Cambridge History of Science Series".

Seit 1995 ist Numbers gewähltes Mitglied der American Academy of Arts and Sciences. 2008 wurde Numbers mit der George-Sarton-Medaille ausgezeichnet, dem höchst renommierten Preis für Wissenschaftsgeschichte der von George Sarton und Lawrence Joseph Henderson gegründeten History of Science Society (HSS).

Schriften
 The Creationists. The Evolution of scientific Creationism, New York: Alfred A. Knopf, 1992 (erweiterte Neuauflage: The Creationists. From scientific Creationism to Intelligent Design, Cambridge MA: Harvard University Press, 2006)
 Darwinism Comes to America, Cambridge, MA: Harvard University Press, 1998.
 Disseminating Darwinism: The Role of Place, Race, Religion, and Gender, Cambridge: Cambridge University Press, 1999.

Weblinks
 Academic homepage
 PDF-Datei mit akademischem Lebenslauf (616 kB)

Wissenschaftshistoriker
Hochschullehrer (Madison, Wisconsin)
Mitglied der American Academy of Arts and Sciences
US-Amerikaner
Geboren 1942
Mann

redpajama_set_name: RedPajamaWikipedia


The faculty and fellows in the Division of Pediatric Cardiology have a wide variety of research interests in clinical, translational, and basic investigation related to childhood heart disease.
Study of the complex and nonlinear response of the cardiac electrical system to rapid pacing in order to understand and potentially prevent the transition from a stable to an unstable cardiac rhythm utilizing multifaceted experimental and theoretical methods to drive the development of computer models.
Jennifer Li, MD, Chief of Pediatric Cardiology Research, has several research interests including pediatric hypertension and hyperlipidemia, heart failure in patients with congenital heart disease, thrombosis in patients with congenital heart disease, and enzyme replacement in Pompe disease.
For further information about clinical trials currently being conducted in the Division of Cardiology, please visit Dukechildrens.org.


Mailing List Archive: Throttle sending rates?
"550 5.5.0 Requested action not taken: mailbox unavailable." message.
get quite popular and generate a lot of mail in a short period.
server is set up properly.
queue gets processed at a certain rate.
If anyone has any other advice on the problem it would be gladly received.
> queue gets processed at a certain rate.
> "550 5.5.0 Requested action not taken: mailbox unavailable." message.
> get quite popular and generate a lot of mail in a short period.
submitting names to your mailing list?
> server is set up properly.
(or one of the routers) for that queue.
> If anyone has any other advice on the problem it would be gladly received.
>> queue gets processed at a certain rate.
Would it work to chain 2 exims and set ratelimit on the input of the second?
I don't see why not. But... fugly!
messages from one queue to the main queue.
have two big exim processes running, instead.
> messages from one queue to the main queue.
nothing looking there - so no locking issues. Just move the files.
to pull the ID out of the filename).
Ah right, I could so that.
2. ls -1 -t /var/spool/exim4 |tail 50 | while read f ; do mv "$f"
>> messages from one queue to the main queue.
> nothing looking there - so no locking issues. Just move the files.
> to pull the ID out of the filename).
> > messages from one queue to the main queue.
logic, if you want, but, eh, be careful?


text:
Home » News & Features » Ford Bronco Delayed to Summer 2021 Due to COVID-19
Ford Bronco Delayed to Summer 2021 Due to COVID-19
Yesterday, Ford North America Product Communications Manager Mike Levine shared a photo of a pre-production 2021 Bronco enrobed in new exterior color Antimatter Blue; making patient fans drool with anticipation. Hold onto your bibs, though, because Ford just announced that the Bronco launch will be delayed to summer 2021 due to hitches in the supply chain caused by COVID-19.
Anticipation is high for the re-imagination of this SUV, and SlashGear reported that more than 150,000 buyers plunked down $100 for a reservation for a full-size Bronco within two weeks of the splashy reveal. The number has surpassed 200,000 at this point, and Bronco fans are going to have to wait a little longer.
Ford has already updated its site with this wording: "In early 2021, your Ford dealer will be able to provide an approximate date for the delivery of your Bronco. Initial Bronco 2- and 4-door deliveries are targeted to begin in June 2021. Due to the high number of Bronco 2 and 4-door reservations, deliveries may extend into the 2022 calendar year."
Unfortunately, the Sasquatch package with manual transmission is also delayed now to model year 2022.
The Blue Oval isn't the only brand facing supplier and production challenges. The Big Three have had to retool their plans; production was halted in North America for two months in the spring, and several automakers contributed to the national health crisis by producing ventilators, face shields, and other personal protective equipment with teams of volunteers.
COVID-19 cases and deaths are trending upward sharply in Michigan and around the country, setting new records practically daily. It stands to reason that production of the Bronco at the Wayne, Michigan assembly plant, and the Bronco Sport in Hermosillo, Sonora, Mexico will both be affected.
It would not be prudent to launch vehicles before everything is fully in place, nor does it make sense to put more of its production at risk by pushing it in unsafe conditions.
I'm hoping it's going to be worth the wait.
Previous Post:Fittipaldi set for back of grid start after PU penalties
Next Post:Brown: O'Ward and Rosenqvist are "superstar" status


text:
Surely VR has to be the main form of gaming in the long term future?
Content of the article: "Surely VR has to be the main form of gaming in the long term future?"
It makes a lot of sense to me. Look at the most popular games in the world. They are all multiplayer games. Roblox has 150 million monthly active users, Minecraft has 131 million, Among Us had 500 million (!) at it's peak, Fortnite has several hundred million activated accounts. There are MMOs you've never heard of and Asian market games that have hundreds of millions of accounts, all of them multiplayer.
Look at discord. It has 140 million active users. Look at the increasing trends of Game Awards and digital event coverage. Look at how big Animal Crossing got this year because it was a way to escape from the pandemic and connect people. You saw weddings, talk shows, birthday parties, and even election campaigns held in the game.
The reason why multiplayer gaming is so dominant compared to singleplayer is because people like to hang out with friends and like the community aspect. This is a central human want to connect with others and video games are one of the best ways to connect, but it doesn't stop on a flatscreen.
VR allows people to feel like they are together in the same room. Why would the future be all about discord calls instead of VR hangouts? Why would people watch Game Awards or E3 streams when they can attend the event virtually with others? Why would people continue to seek out this connection that they want in all these virtual worlds when they could use VR to feel truly connected as if in the same room?
Read more: I hate seeing people promote the lie that you can vote with your wallet
Epic Games and Roblox get this, which is why they keep bringing up the metaverse in half of their conversations, because they are building towards a collective virtual space where users can connect and do all sorts of activities. This is why Fortnite did the Travis Scott concert (over 30 million people attended this concert) and why they made Party Royale.
So then, if multiplayer is so central to gaming because social is so central to humans, surely VR has to be the main future of gaming? Maybe we play lots of flatscreen games still but by hanging out in virtual chatrooms and virtual spaces.
Discussion A lot of people blame discord for the lack of social interactions within MMOs these days, and while they might be right, it's never for the right reasons
Tomorrow, 7pm EST. Live, virtual concert in No Man's Sky. Come be immersed. Special announcement video.
Megathread: Chapter 2 – Season 5 Launch
Among Us makes me hopeful for gaming's future
This could be the wrong sub for this kind of thing, but here goes. Among Us (2018), recently took the world by storm, making liars and detectives of all of us. It's success was astounding, becoming part of the collective conscience of people worldwide through Twitch streams, memes and TikToks. It's reach is incredible. I see people who've never played video games huddled round tables playing it. This is fantastic. I'm a firm believer that the more people that enjoy games the better. It leads to more diversity among gamers, which is always a good thing. Its success story is…
Hitman VR controls
So I'm a bit late to the game here I see, bit I've just heard about Hitman 3 having a VR option on PSVR. Holy geez what a dream come true! As I've been diving into whatever info I can find I'm seeing a lot about how they have been running the game with ds4 controls. This seems to have a lot of people bummed out. I'm not too familiar with any of the VR systems as I've been waiting on the tech to get better enough to offer an experience that wasn't to "gamey/arcadey" and give us something as…
Unsolicited Iron Man VR review
Overall, I'd call this game "missable" the excessive loading screens are frequently disrupting gameplay and the game relies on dialog over black screen so often, it took me a little while to realize that the game was designed that way and that I wasn't just having technical issues. The end result means that close to half of your time with the headset on is not only spent with nothing to do, but also nothing to see. While one or two levels are pretty, their minuscule scale and an obnoxiously intrusive HUD prevent you from truly experiencing them. After starting you…
More about Gaming News
Post: "Surely VR has to be the main form of gaming in the long term future?" specifically for the game Gaming News. Other useful information about this game:
I think I finally "got" Dishonored
Why have there been so few 'GOTY' level games for PC in recent years?
Since the release of Cyberpunk 2077, one of the complaints i've been hearing online is "It's not an RPG game" which…confuses me beyond belief
Murlocs are ruining battlegrounds
If you are having a hard time in Tarkov…
An Unconventional Nova Rework
Why diversity in video games can sometimes be smooth and other times be jarring
The Watch_Dogs Franchise Story Dossier(Storyline Summary of everything from the games, novels, comics and expansions)
Newbie DM with newbie players seek help for its campaign
Getting my players to take a plot hood – advise/help
Sep 16, 2020 4:34 am
EFT's tactical systems being thwarted by movement
2020 World Championship / Semi-finals – Day 2 / Live Discussion
Where's the male love?


Discussion in 'UFOs, Ghosts and Monsters' started by darksidZz, Apr 19, 2016.
You got sold s pup there river.
A whole bloody litter in fact!
Sherlock Holmes (/ˈʃɜːrlɒk ˈhoʊmz/) is a fictional private detective created by British author Sir Arthur Conan Doyle. Known as a "consulting detective" in the stories, Holmes is known for a proficiency with observation, forensic science, and logical reasoning that borders on the fantastic, which he employs when investigating cases for a wide variety of clients, includingScotland Yard.
There you go a fictional character.
I don't think its a great idea to put your faith in a fictional character River.
Now you see the author has made you believe something he just made up and had a fictional character say it.
Still you must have thought the idea was rather a wild generalization... I know you knew and you wanted to see who you could trap.
You are just too clever River and I bet s lot of folk would go along with the proposition because it sounded as if someone famous said it.
You entirely missed it .
I will come back on it later if I can.
However if you had have dignified the premise as your concept I would have given it some earlier thought.
However I don't get my wisdom from books of fiction.
My experience comes from real life observing real people make real mistakes.
If I want to know how to do something I am not going to take advice from a fictional character.
Maybe the reason I don't buy the UFO stuff on face value is because I have only ever lived in the real world watching humans say and do all sorts of crap for all sorts of strange reasons.
So many humans want attention and will say all sorts of stuff to get it.
Many do stuff for money, even to impress a girl.
They say you learn by your mistakes well I not only had mine to learn by but also a procession of clients and countless recorded cases of law where facts are recorded and judgements that are there for folk to understand where other folk went wrong.
Now that is a cut above what some fictional character offers from the mind of a mere fiction novelist.
A novelist they live by selling fantasy for goodness sake River.
Come on now give me credit for not taking Sherlock seriously.
You want to rely on his method be my guest I will look into it later.
Have you ever talked to a real detective River and asked what said detective thinks about Sherlock Holmes.
I confess I have not but I think I know what they may say.
Tell you what I will do, because I really do enjoy talking to you River, I will think about what Sherlock says and for the sheer fun of it I will see if I can present a refutation of the premise.
Refutation , ahhhh... again you missed the point .
t when you have eliminated the impossible, whatever remains, however improbable, must be the truth?
First how long do we make the list of impossible?
Is it relevant to even list the impossible.
Perhaps a list of countless probabilities so out of that list how do we select anything that can be considered the truth.
Would you care to suggest how using Sherlocks approach we can determine any truth relating to UFOs given that is sortta related to this thread topic.
Perhaps try applying Sherlocks approach to address the op.
And if you are genuine give me more than short answers that convey little about what you mean.
Shortness of answers don't sound wise if they don't convey something which means something.
I type one finger on a smart phone so if you have a key board type a few more words than normal.
Figure it out Alex , your the smart one .
You have to hold back on the compliments River.
I am not too smart I am an old man I have forgotten so much you would not believe.
But I will take it you don't wish to build upon Sherlocks wisdom and fair enough you no doubt now see the flaws in the idea.
Moreover you probably have more important things to do than waste time proving a fictional character is somehow smarter than real people.
Good night , may you dream upon Sherlocks logic .
river wallows in mystery, mystique, and evasiveness: He is the champ of oneliners...or should that be chump?
I had a friend who spoke in a similar way convinced that he sounded profound but he was just an idiot.
You could ask him to explain but he would only get worse quoting nonsence making out he was wise but in all the time I knew him the only intelligent thing he really said was "not everyone is like me"... Happy days. Even if you asked him if he would like another beer he would carry on.
I nearly smashed him one day but I got up and simply left without a word.
Damn idiot should have smashed him see what profound sounds like with teeth missing.
I don't really want to pile on a particular poster, but I'll address the behavior.
The tactic of sounding pithy and mysterious is a common one that almost all of us engaged in when we were younger.
They're not really convinced themselves; it's a bluff, to try to convince others. It becomes quite transparent when you call the bluff, and there's nothing to back it but more enigmatism.
It's a phase that most people grow of. Once one sees how transparent it is to others, and they're not fooling anyone, they usually drop it.
As a tactic, it's relatively harmless. There are far more odious and damaging behaviors here.
Don't get me wrong I like River.
I was reminded that's all.
And a lot of the time I understand what he means.
I expect he is a busy person and tries to be brief.
Also he probably realises I am an ear bender and does not want to get too deep.
All good my end still celebrating the election result only started with asprin this time before a drink.
My bank book went through the wash so I hope I don't get charged with money laundering.
Think of why the US government hides the UFO's in the first place . We all know that they happen and about 10 to 5% never get resolved . and the government does what it can to hush people up . It's sort of a reverse psychology if you will , in the open .
The US hushs up airline pilots , military forces personal , police , citizens ; of any sightings or experiences with UFO's.
Think of why the US government hides the UFO's in the first place .
This is exactly what was asked in post 1, and shown to be flawed in post 11.
Bringing it up 1100 posts later doesn't change that.
The question of why the government might do something cannot be meaningfully asked until it is granted that the government does it.
In a moment I'm going to start asking 'Why does River eat kittens?' And you'd better have a good reason.
Examine Roswell ; classic example .
The papers at the time , say that a flying saucer crashed at the sight .
The day after it was a high tech. ballon.
"...a United States Air Force balloon, mistaken for a UFO, crashed at a ranch near Roswell..."
"The sequence of events was triggered by the crash of a Project Mogul balloon"
So ... so far, no, it doesn't.
Do you think you could make that glaring mistake of shape ?
And remember it was the RAAF that said it was a saucer , originally .
The article you linked to as evidence for your assertion that the government hides UFOS - says quite explicitly, and multiple times, that a balloon crashed, and that conspiracies did not well up until several decades later, in the 70's.
So, the evidence is that a balloon crashed.
Is it rational to go from a saucer shape to a ballon object ?
If you wish to re-pen arguments about the Roswell case, start a new thread.
But you've nicely disqualified it as any support for this thread.
So, the issue stands: it has yet to be established that the government hides UFOs.


I never buy Emma pajamas. Mostly because when I'm looking at what I need for her for the next season I never think of them, but also because nearly all the pjs you see are covered in brands, logos or TV characters. Emma has heaps of time to wear all that commercial stuff (and hopefully she won't be that interested), so until that monster rears its ugly head I'd like to avoid it if possible.
So, with the weather starting to change I thought I should get stuck into some winter pajamas for Emma, and luckily my Make it Perfect book by Toni Coward has a great pattern! You can take a look at this book here.
Sewing stretch is much harder than I thought, and even after putting these together I'm still not sure I have it right. The t-shirt is a bit puckered, and I'm worried the stitching on the seams of the pants won't hold. More investigation (and of course practice :) is needed!
And a picture in action! Emma was not a particularly willing model today - its SO hot that wearing winter pjs around for a little while didn't interest her one little bit (not that I can blame her). But I did get one good shot!
They are a bit big yet - but as there are a few months yet till winter I wanted to give her some growing room. Looking at this photo again - they are just so cute!!!


text:
Jet2 grounds all flights and suspends holidays until end of March in latest Covid move
The company initially extended the suspension of winter sun flights to the Canary Islands, Madeira and Turkey until February 12
Airline and tour operator Jet2 has axed all flights and holidays until March 25.
The decision follows the announcement of the latest lockdown by UK governments. The company initially extended the suspension of winter sun flights to the Canary Islands, Madeira and Turkey until February 12.
However, Jet2 has now decided to expand the ban across the whole of its operation.
A spokesperson for Jet2 and Jet2holidays said: "Due to the ongoing uncertainty and travel restrictions caused by the Covid-19 pandemic, we have taken the decision to extend the suspension of flights and holidays up to and including March 25.
New link to Lisbon confirmed by Jet2 with flights starting in September
Jet2 unveils summer 22 holidays and flights - despite continuing lockdown uncertainty
"Where customers yet to travel are affected by any programme changes, our approach to providing smooth and speedy refunds has been widely praised, and we will be automatically cancelling affected bookings with a full refund.
"Since the onset of the pandemic, we have always respected that customers should receive their money back if we have not provided their flight or holiday.
"Our customers work hard and save hard for their holidays, and we are very excited to take them away on holiday again. For customers due to travel from March 26 onwards, we will provide further updates closer to the time as appropriate.
"We would like to thank our valued customers for their patience and understanding."
More than £1 billion has been paid by Jet2 in Covid-19 related refunds since the start of the pandemic in March 2020.


There's a common misconception about Civil Rights in America, that we made more progress on the issue in the 1950's and 60's than we are now. The theory tends to take the position that Civil Rights progress then has made white America more conservative, and opposed, to more progress. There's decent evidence to that end- Democrats saw their share of white voters begin falling considerably by 1968.
I think we're missing a huge, key point there though- the perceived cost of Civil Rights to the majority has changed. For most of white America in the 1950's and 60's, Civil Rights was something happening elsewhere. It was mostly an issue of Jim Crow, Segregation, and "hillbilly" cops being violent in the South. African-Americans were merely asking for voting rights, physical safety, and access to public education, and mostly in just one region of the country. White people in other parts of the country found Bull Connor, George Wallace, and the Ku Klux Klan kind of embarrassing and hard to defend. It wasn't hard to support Civil Rights against some other white people, in some other place. Besides, the South has always been rebellious and poorly behaved. The cost of supporting Civil Rights in the 1960's, while historic, was relatively low for white people.
Beginning with the push to integrate busing in the 1970's, the math began to change. Integrated busing meant an end to de facto segregation in schools nationally. Confronting policing issues was one thing when it was Rodney King in Los Angeles, or a celebrity trial like OJ Simpson- it's totally different when the shooting is down the road in South Whitehall Township, or Pittsburgh. Confronting the lack of minority inclusion in the ranks of our CEO's, Senators, and Hollywood producers is less convenient. Providing quality public education, through spending actual money in impoverished urban areas can pit African-Americans vs. wealthier white suburbanites quite often. Confronting implicit bias and systemic racism means confronting one's own behavior, not some other white person in some other place. It also means accepting the premise that the LBJ signed, 1960's Civil Rights legislation was a start, not a conclusion on the road to a more just, equal society, which can be hard for some to comprehend.
I understand that for many white people, Civil Rights progress just can't be a priority for them. A lot of progressives mock this concept, but the truth is that life isn't that great for white working class people in 2018. The factories with their unionized, family sustaining wage paying, unskilled labor jobs are gone. Opioid addiction, Wal-Mart jobs, ever rising local taxes, mounting personal debt, and home foreclosures are in their place. While they're wrong, I understand why they are dismissive of the concept of white privilege. I'm not dismissing the racial bias and explicit racism that exists with a large chunk of these people. I'm simply acknowledging that we should have some sort of compassion for people who are frankly being defeated by life, are afraid of a changing world, and aren't privileged enough to change their own lives, let alone the world. I'm obviously not too happy they decided to unleash the forces of Trump on America, but I do understand why it happened.
Civil Rights fights moving forward aren't going to get easier. Progress in 2018 is harder, and requires actual changes to everyday society. Not everyone is going to find "the juice is worth the squeeze." Voters have always voted self-interest, and probably will continue to, meaning there may not ever be a majority of voters casting their ballots for a pro-Civil Rights agenda. With more political polarization and scarcer resources available, the reality is that progress is only going to be harder, not easier.


I do believe today you want merchandise, so you are in right web site. At this point you are studying DHP Bentwood Round Dining Table Top, Contemporary Design for your Kitchen, Legs sold separately – White write-up. And I'm hoping you can find useful details with the following before you purchase product. At the moment I must talk about DHP Bentwood Round Dining Table Top, Contemporary Design for your Kitchen, Legs sold separately – White. Minor info that DHP Bentwood Round Dining Table Top, Contemporary Design for your Kitchen, Legs sold separately – White merchandise is manufactured by DHP organization.
To learn more in relation to DHP Bentwood Round Dining Table Top, Contemporary Design for your Kitchen, Legs sold separately – White price tag and also critiques, you are able to simply click THIS LINK . Lets hope this particular article can assist you to contemplate throughout buying involving DHP Bentwood Round Dining Table Top, Contemporary Design for your Kitchen, Legs sold separately – White product. Or we hope in which using this article you to definitely find different merchandise that is certainly related with DHP Bentwood Round Dining Table Top, Contemporary Design for your Kitchen, Legs sold separately – White or maybe superior.
When you finally study that DHP Bentwood Round Dining Table Top, Contemporary Design for your Kitchen, Legs sold separately – White, we all expect that this DHP Bentwood Round Dining Table Top, Contemporary Design for your Kitchen, Legs sold separately – White product can be match for you. If you're more dedicated people however ought to find item besides DHP Bentwood Round Dining Table Top, Contemporary Design for your Kitchen, Legs sold separately – White, you'll be able to check out inside every single classification or perhaps use look for field on this blog site. Then should you be certain to buy DHP Bentwood Round Dining Table Top, Contemporary Design for your Kitchen, Legs sold separately – White, please click on BUY BUTTON down below.


The social giant has subtly made it harder to find some of its most controversial accounts and, naturally, some of Twitter's biggest trolls are unhappy about it.
New changes on Twitter have made it harder to find some of the site's most controversial far-right users.
Prominent right-wing Twitter accounts, including a writer for conspiracy theorist hub InfoWars and white-nationalist figures like Richard Spencer and Jason Kessler, appear to have been hit with a number of new measures meant to reduce their visibility on the platform.
"Free speech is in dire threat," warned InfoWars personality Paul Joseph Watson.
Twitter has struggled with how to deal with far-right personalities who whip up abusive troll mobs or push hoaxes and racist content. In May, the social-media giant announced that it would make changes to "communal areas like conversation and search" in an effort to make troll accounts less visible.
Twitter declined to comment on the apparently new changes to how the site treats certain accounts, referring The Daily Beast to the May blog post about limiting the reach of trolls.
One of the new changes, first reported by Gizmodo, affects how certain accounts appear in searches on the site. Twitter's search no longer auto-suggests the Twitter handles for various right-wing provocateurs. A search for far-right figure Mike Cernovich, for example, no longer auto-fills with a link to his Twitter handle, instead suggesting several parody accounts. If a Twitter user completes the search, though, they can find Cernovich's actual Twitter account.
The search change appears to have hit a number of other right-wing figures, including pro-Trump provocateur Laura Loomer, popular far-right blog Gateway Pundit, YouTube philosopher Stefan Molyneux, and InfoWars' Watson.
The search change appears to have mostly affected more fringe figures on the right, as more mainstream Trump-era conservatives like Ben Shapiro and Fox News hosts Sean Hannity, Laura Ingraham, and Tucker Carlson remain unaffected by the new rules.
Figures on the right started to claim last week that they're being affected by "quality filter discrimination," a reference to the "quality filter" Twitter instituted in 2016.
Using a third-party online tool that claims to show whether a Twitter account has been deemed "low-quality" under the tool, conservatives have claimed that their tweets have been reduced in visibility on the site. Conservative accounts complaining about the quality filter say this makes it difficult for Twitter users who have enabled the quality filter in their Twitter preferences to see their tweets.
It's unclear how the "quality filter" issue actually affects how tweets appear. In a House Judiciary Committee hearing last week, a Twitter representative denied that it was banning conservative accounts, saying the company limits accounts based on their "behavior," rather than their content.