text:
Atm protein bilaterally toward clusters of somatic gonadal precursor cells
Posted on June 30, 2012 by jaki3196
icroarray sections essentially as previously described. The following antibodies were used for immunocytochemistry: Nestin, clone MAB5326. In fruitflies, PGCs are atm protein initially specified by maternally derived mRNAs and other germ plasm components that are localized to the posterior end of the early embryo. During gastrulation, the Drosophila PGCs are carried with associated somatic cells to the posterior midgut, after which they traverse the midgut epithelium and attach to the overlying mesoderm. The PGCs then migrate bilaterally toward clusters of somatic gonadal precursor cells, with which they coalesce to form the gonad. Zebrafish PGCs are similarly specified by maternal germ plasm determinants, in this case localized to the cleavage planes at the two and four cell stages.
By the 1000 cell stage, the zebrafish embryo contains four PGCs in a square like configuration that is randomly oriented with respect to the dorsal ventral axis. The PGCs then begin to proliferate, and between 4 and 5 hpf they transition from round, immotile cells into a polarized migratory population, localizing to the anterior and lateral Asiatic acid p38 MAPK inhibitor boundaries of the mesoderm during gastrulation. The PGCs continue to migrate toward an intermediate region bordering the mesoderm during somitogenesis, until 25 to 50 cells are bilaterally restricted to the anterior end of the yolk extension at 24 hpf. The long range migration undertaken by PGCs has garnered particular interest not only as an integral step in gonad development, but also as model system for the study of directed cell movements in vivo.
Imiquimod Previous studies have revealed several factors that are necessary for both PGC migration and survival. For example, germ plasm in Drosophila and zebrafish contains a conserved suite of PGC specific mRNAs, including vasa and nanos, and embryos lacking these transcripts or the proteins they encode exhibit mislocalized PGCs that are ultimately lost. In fruitflies, PGC motility and maintenance is further regulated by lipid phosphate phosphatases encoded by the wunen genes, which appear to produce a repellent signal. Zebrafish PGC development is also regulated by the dead end gene, which is essential for PGC migration and survival. A second class of factors is required for PGC migration but not survival, regulating either the basic motility of these progenitor cells or their chemotaxis.
For instance, zebrafish PGCs deficient for phosphatidylinositol 3 kinase signaling have reduced speed but maintain their capacity for directed migration. Similarly, E cadherin is downregulated in zebrafish PGCs as they begin to migrate, and its aberrant upregulation reduces PGC migration speed but not directionality. Other genes are required for the chemotaxis of PGCs but not their general motility. Such factors include the zebrafish chemoattractant stromal derived factor 1a and its receptor cxcr4b. PGC chemotaxis in both Drosophila and zebrafish also requires the enzyme 3 hydroxy 3 methylglutaryl coenzyme A reductase. In fruitflies, HMG CoAR is selectively expressed in somatic gonadal precursor cells during the second phase of PGC migration, and loss of this gene in columbus mutants results in PGC mislocalization. Conversely, cells ectopically expressing HMG CoAR can attract migratory PGCs. Since this enzyme is
Proteasome inhibitor of growth factor receptors such as ErbB1 4 inhibitors and antique
And synthetic chemists to produce therapeutically effective proteasome inhibitor inhibitors, in particular kinases, especially agents that bind in the ATP-binding site in the kinase Cathedral sharing plans. Important examples are: the small molecule inhibitors of growth factor receptors such as ErbB1 4 inhibitors and antique rpern, PDGFR, c Met and IGF1R, FLT3, Abl tyrosine kinases and c-kit family kinases Src tyrosine checkpoint / regulatory CHK1 kinase, the vascular Ren endothelial growth factor receptors, heat shock protein 90, Aurora kinases, cyclin-dependent Independent kinase, phosphatidylinositol 3-kinase, mTOR, RAD001 AP23573, CI779, BEZ235, PI103, I κ B kinase, AKT, MEK1 / 2, Raf kinases, Ras farnesylation / geranylgeranylation.
In addition to the agents involved in kinase activity th, other therapeutic drugs that have been developed recently to the biology and / or modify t th tumor cells are those that: Modify protein acetylation Ver countries, the activity t can be reduced by Bcl-2 family protection in the mitochondria, and agents of the activity t of proteasome k. Some of the above substances in vitro and in animal models were combined to achieve a synergistic increase in the Abbot Maintenance of tumor cells in vitro, for example, many types of tumor cells has been shown that growth after the reduction inhibition of growth factor receptors, For example, ErbB1 or inhibition of signaling pathways. However, in several studies on the effect of a main-kinase inhibitor alone at doses lower specific targets on tumor cells was cyto static liked t as cyto-toxic.
In contrast to the relatively encouraging pr Clinical in-vitro studies, clinical studies show where most of the above inhibitors as single agents do not often any form of contr The tumor growth. As a result, the patient results with kinase inhibitors as a single agent is a big e was amount of literature in pr developed Clinical models, which show that the inhibition of growth factor receptors and / or downstream signaling molecules k Can F Promotion cell death by a plurality of established cytotoxic therapies including normal ionizing radiation, the microtubule agent-related, and topoisomerase inhibitors and other Sch dlinge DNA induces agent. Thus, when combined with established cytotoxic agents, k Can browse the kinase inhibitors verst Strengths of their toxicity t and showed a contr The tumor in patients with FDA-approved for the sp Tere use, such as ionizing radiation and cisplatin, and capecitabine.
Where a receiver singer targeted anti-cancer responses were induced at the st Strongest pronounced Gt in patients, such as imatinib in CML Bcr Abl has been hypothesized and demonstrated that the effect of control The tumor was on cells of CML exquisitely to the kinase activity-t of Bcr Abl fusion protein for growth and survival depends Dependent. Similar results were obtained with imatinib were in the gastro-intestinal tumors, a mutant form of the active c-kit made for expression. In contrast, non-small cell lung cancer, although the tumors tend to 70% of patients overexpressing ErbB1, only a small subset of patients to ErbB1 inhibitors and these people to be statistically Non smoking and with an Asian / female genetics. Subsequently End was shown in patients with NSCLC sensitive conceptuall in a
GDC-0449 Vismodegib signs of activity t in phase I clinical trial and other trials
Stuzumab works through a mechanism of ADCC has led some researchers to determine whether this activity T can be additionally USEFUL immunostimulatory Ans Tze improved. accordance with this hypothesis, IL 2 enhances the ADCC activity t of trastuzumab in vitro. However, a phase I trial with this combination modality GDC-0449 Vismodegib was t no evidence of clinical activity T with an increased Hten associated IL-2 induced expansion of NK cells. In another approach, an antique Body, the HER2 has been developed two specific and CD3 antigen on T cells targets to T cells, to obtain tumor cells. This agent has shown promising signs of activity t in phase I clinical trial and other trials are underway to determine their antitumor activity, as shown.
In another approach, the in vitro ADCC activity of t verst of trastuzumab by defucosylation Are RKT, fucosyl negative version of trastuzumab Imiquimod have been proposed for clinical trials. These models pr Clinical experimental and clinical observational studies have convincing evidence that the most anti-tumor activity of t is mediated by immunological mechanisms of trastuzumab specifically made available. Although these file records Still relatively low, the failure led mediates the signaling field to the clinical efficacy of trastuzumab confirm to the inhibition of HER2 signaling to the attention of more and more the further assumption immunological targeting and additionally USEFUL studies to explore further, to focus this hypothesis are underway. A second monoclonal antibody Body against HER2 is currently in clinical trials.
From the initial screen of the fight against HER2 monoclonal Rpern at Genentech, Inc. has developed mAb 2C4 hlt for the characterization and development of weight And has different properties of mAb 4D5. mAb 2C4 was developed for clinical use, modified to produce human recombinant humanized version of pertuzumab. Pertuzumab is currently being addressed in clinical studies and clinical development to date for diseases other than cancer overexpressing HER2. It is s anti-tumor activity of t in HER2 overexpressing breast cancer are not known, but it has little activity T disabled in breast cancer without HER2 overexpression and ovarian cancer. The activity Th of 2C4 or pertuzumab have on cell signaling pathways investigators selected from these funds Was selected, reports are not yet available for the study of broader scientific community available.
In comparison with mAbs 4D5 or trastuzumab, a monoclonal antibody Body 2C4 much less activity t in vitro anti-proliferative, but has antitumor activity t in vivo in a variety of tumor types, including normal tumors without HER2 overexpression. 2C4 is reported that the HER2 receptor mediates heregulin complex formation, phosphorylation and activation of Akt and MAPK in breast cancer cells without HER2 overexpression to inhibit. Determination of HER2 overexpression effects of pertuzumab to cancer expected a lot more pr Clinical and clinical studies. Technology, selective inhibitors of tyrosine kinase for human therapeutic Antique Body was to develop successfully by almost a decade. This means, at least in theory, have certain advantages over antique Body therapies for the treatment of HER2 verst RKT cancer. Antique Body therapies undurchl cells Ssigen means that the extracellular Re cathedral remains Ne of the first bind HER2 protein and uncle
GABA inhibition is largely controlled controlled by the host cell You
Ment inhibited when parasite central axis and then contained in the process of abscission. It is not known whether parasites own structure information, especially for the preparation of his or constriction when GABA inhibition such signals are from the host cell They offer. However, once a central axis / center of the K Integrated rpers, the parasite has no effect on the host cell Central feature, you pin or cutting, and from this point appears to be a process schizonts cytokinesis, adhesion, which is largely controlled controlled by the host cell You. This is achieved by the fact that in the absence of cell abscission h You independent Ngig parasite division occurs are not supported. In summary, we propose a two-stage model for Theileria schizont dividing into daughter cells are separated, where the first mitotic spindle and subsequently the central axis.
As the host cell It enters mitosis, binds the MT schizonts forming new symmetrical starting from TGF-beta receptor p From the time, so that the schizonts position itself so that it extends the range Equatorial of the cell where the mitotic chromosomes of cells h Their assembly may need during the metaphase. This step is independently Ngig of PLK1 activity t occurs as it even in the presence of inhibitors of PLK1. W During anaphase is, the schizonts closely with the central pin assembly in the central region between the chromosomes separate associated. Unlike the first step requires the interaction of PLK1 is catalytically active.
Due to the diversion, the central axis, an important regulator of the formation of cleavage furrow area, axitinib the schizonts is strategically positioned in the plane of cell division, each cell cytokinesis h be included You, without the process to st Ren. W is integrated While ie the conversion of various viruses in the genome of the host cell They persist or mitotic chromosomes, aims to develop the transformation of the protozoan Theileria isolate the mitotic apparatus, which mediates chromosome segregation and cytokinesis. Given the strict intracellular schizonts is And re entered his Pr Presence essential for the constitutive activation of signaling pathways, cell proliferation Ment and protection from apoptosis, we ask that this process is not only essential for the persistence of parasites, but also for the exponential expansion of parasites Bev Lkerung.
Have developed in a broader context, there is increasing evidence from studies of protein-protein interactions that pathogens to target proteins H Their function as hubs or Engp Sse. In previous work we have shown that Theileria away IKK, a central regulator of numerous pathways NF-kB activation. Scanning PLK1, a key regulator of mitosis, provides a second Theileria striking manifestation of this evolution Ren process. Materials and Methods Cell culture and transfections Theileria annulata infected macrophages were in Leibovitz 15 medium with 10% f Fetal K Calf serum, 10 mM HEPES pH 7.2, 2 mM L-glutamine, 70 mM mercaptoethanol b cultured, and antibiotics. The cell line transformed with SV40, bovine macrophages Theileriauninfected in DMEM Glutamax was complements medium containing 10% FCS and antibiotics erg. Plasmids, Including the myc-tagged versions of human PLK1 Lich full-length wild-type PLK1, PLK1 kinase dead full-length, wild-type kinase Dom ne
Neuronal Signaling of plasma pharmacokinetic profile of H4 acetylation in solid tumor
Acetylation was strong, but after 3 h, decreased the acetylation Neuronal Signaling levels at low and medium. Similar levels of H4 acetylation were observed for spleen tissue. H4 acetylation was not detected in the spleen contr and tumor tissue of M Nozzles The vehicle. If the correlation of plasma pharmacokinetic profile of H4 acetylation in solid tumor tissue, the study found that the activity T belinostat, as indicated by the surrogate marker acetylated H4, was present, as long as the plasma concentration was above 1000 ng / ml How does the plasma concentration belinostat, H4 acetylation in tumor tissue does also. Histone acetylation in PBMCs discussion is often used as a surrogate marker for HDAC activity t and showed a correlation with the plasma concentration.
Pharmacokinetic studies showed linear pharmacokinetics with dose proportional increases in Cmax and AUC for vorinostat and linear pharmacokinetics independent Ngig demonstrated with the dose for MS 275th Although the time to Cmax demonstrated Similarity between different HDAC inhibitors, there were big e variations in the terminal half-life between HDAC inhibitors. 389 Evaluation of five cell lines than in Nacktm Mice showed increased differences in their usefulness as models of the biopsy that was likely the differences in the tendency of the necrotic tumors. PC 3 and MCF-7 tumors showed less of acetylation after 1 h, based on A2780 tumors. It is unclear whether this difference is due to decreased acetylation efficacy of the drug in specific tissues or due to differences in the Lebensf Ability of the cells.
The PC 3, MCF-7 and HCT 116 samples in liquids and necrosis, which hinders the collection of biopsy. Biopsies of tumors contained A2780 vital tumor tissue in a more appropriate model. In addition biopsies were typical A2780 tumors at the level of H4 acetylation. Initial studies have shown that the method had the biopsy detecting no effect on histone acetylation. H4 acetylation was incubated in tissue 15 after the treatment of tumors detected belinostat and the H Highest value was reached after 1 h. In a previous study, the increase in H4 acetylation in peripheral blood was found after 10 min intravenous infusion of canine belinostat given over 45 min. In addition, the investigators found increased Ht H4 acetylation 30 min after treatment with 1 mM belinostat in histones extracted from A2780 cells.
We observed that two biopsies after 3 h was h Ago collected as tumors corresponding acetylation. F Mixed staining of tumors with low acetylation in the middle than at the periphery. This problem nnte k The result of the binding epitope is insufficient or too short to be tumors. Nevertheless, our results showed that the H4 acetylation levels of baseline 3 h after treatment. In Similar way, Plumb et al. found that H4 acetylation had to baseline levels in A2780 and A2780 xenografts histones from cells in peripheral blood extracted 3 h after treatment with belinostat returned. Our results of the follow-up study showed different levels of H4 acetylation in pretreatment biopsies from a variety of M Mice, indicating that it is important to collect pre-treatment biopsies have a contr The internal reference H4 acetylation. In a clinical trial, h Higher doses of the HDAC inhibitor Z
HDAC inhibition ability mitosis appears in solid tumor cell lines on the hand
5 days on the morphology of the cells was determined by optical microscopy and showed significant Ver Changes in cell structure and growth of cells in all cell lines. In particular, the treated cells were gr It than untreated cells, suggesting an increase in forward Rtsstreulicht w During flow cytometric HDAC inhibition cell cycle analysis was best CONFIRMS, demonstrated by the results in Figure 3A MiaPaCa 2 cells. The effects of AZD1152 HQPA on the chromosomal location and structure are cells examinedtumour impact Herk Mmlichen cytotoxic agents, which reduces the toxic effects. These F overcome Ability, the concerns of the cell cycle, and again the F To give ability mitosis appears in solid tumor cell lines on the hand, but not in an AML model in which a 48-h exposure to AZD1152 hQPA reduced the F ability of the cells undergo clonal growth when plated in fresh medium, suggesting an inverse correlation between the recovery of the F ability of cell growth and increased Hten DNA.
Our results agree with those produced by Nair et al, a small induction of apoptosis following 48 h of treatment of HCT116 cells with AZD1152 HQPA reported. Our study is also consistent with verst a recent study in which CPT-11 AZD1152 Markets activity t in dependence Dependence on timing. ABT-888 912444-00-9 In this study, the best schedule of administration, when the Aurora kinase inhibitor was given before cytotoxic drug. We also showed anything similar effects as the combination of hourly load AZD1152 HQPA either oxaliplatin or gemcitabine.
A m Possible explanation Is enclosed in the F Ability of AZD1152 to induce polyploid HQPA Die, who states Will not be complete for the erh Hte induce F Ability of chemotherapeutic agents for apoptosis of cells endoreduplicating. AZD1152 HQPA operates by inhibiting the phosphorylation of histone 3, although it also modulates other signaling pathways, such as paths survive the involvement of the p53 tumor suppressor. In the analysis of cellular Ren targets modulated by AZD1152, we focused our attention on the modulation of p53, and according to Nair et al, we found that AZD1152 is obtained with a Hten Ma associated expression of these tumor suppressor protein was, but only if it was wild type. Conversely, in cell lines of pancreatic cancer with mutated p53 modulation was absent, although its pharmacological treatment is promising in vitro and in vivo.
Our study underscores the importance of determining the best medicine of sequential lacing to optimize the combined administration of a new therapeutic approach. The F Ability to use as enhancers AZD1152 HQPA efficacy of oxaliplatin and gemcitabine, was tested in the C Lon and models of pancreatic cancer, respectively. Promising results obtained in both models, especially given the calendar, where HQPA AZD1152 prior gemcitabine or oxaliplatin was in support of an r Positive for AZD1152 as reinforcing Amplifiers of antitumor effect of standard care chemotherapy in patients with colon and pancreatic cancer. We decided to validate our hypothesis in an animal model to begin Ant by the model of pancreatic cancer with a pancreatic tumor xenograft. Tats Chlich, the combination of gemcitabine with AZD1152 in a row to the m Possible importance of sequence-dependent Indicate Independent effect, because the sequential combination has an average effective than any sin
PARP Inhibitor analysis of the transcriptome profile of these samples suggested
Oh TKI failure, since sequential TKI Age was associated with a response. conducted a detailed analysis of 27 samples RCC. DNA Ver Changes PARP Inhibitor in copy number and loss of heterozygosity events were analyzed using the unique technology-nucleotide polymorphism array. Au OUTSIDE the zones previously recognized DNA-Sch To, the range map of the genome revealed several new sites of deletion, amplification and LOH. Simultaneous analysis of the transcriptome profile of these samples suggested that 27 genes were differentially expressed in regions of the amplified DNA. For example, transcripts encoding lysyl oxidase and CXC-chemokine receptor 4 were were found to upregulation of specific regions of DNA connected fa Simultaneous administration verst RKT.
Both LOX and CXCR4 plays m for may have an R Crucial role in the metastatic potential of tumor cells, perhaps the F Promotion Imiquimod of trade of tumor cells in niches premetastatic. Ultimately, in combination with genomic and transcriptomic profiling unique targets for the treatment of kidney cancer to make, and can offer an individual prognostic information. A better fully understand the epigenetic Ph Phenomena can k Also provide a different characterization of renal tumors. A panel of 18 cancer genes has been methylation status in a pool of 85 resected RCC samples and examined 62 pairs of samples from normal tissues. Remarkably, the genes fell into one of the many groups, including normal involved in the cellular Munications, the nucleic Acid metabolism, signal transduction, energy regulation and the end of the cell cycle.
Methylation patterns were involved in CDH1 and RASSF1A Altered in cell communication and cell cycle progression, are observed. The differences in methylation patterns were also between clear cell and not of clear cell RCC samples eg PTGS2 methylation was evaluated in clear cell, in contrast to papillary Ren RCC ht obtained Noted. In a row Similar but separate experiments, 38 samples from patients nephrectomy RCC, methylation of 19 genes that are noted in RCC underexpressed were evaluated. A total of five genes hypermethylated found, and among them were two tumor suppressor genes. These epigenetic Ph Phenomena can therefore identify characteristics of the RCC samples, and when in a green Validated eren cohorts, k Nnte serve as a grave prognosis or prediction tools.
A broader concept of subtypes of cancer are also some genetic Ver Changes that affect more uniformly Ig cancer growth and dissemination by histology. For example, judges et al Beroukhim 3.131 cancer samples in 26 histological subtypes. Due to the high resolution and high somatic analysis Ver Changes in copy number, it was found that genes that were included with BCL2 genes and fragments along the NF B signaling enriched κ assigned. Two peaks were observed for amplifications of genes BCL2 and MCL1 Bcl2l1 searches. Subsequent experiments comparing MCL1 verst RKT and not verst RKT cell lines showed a st Verst rkere growth inhibition in MCL cell lines with RKT an shRNA treated. Similar results were VER U Ert experiments evaluating Bcl2l1 inhibition in various models. Proteomics compared to gene expression profiles, the amount of data on renal tumor proteomic profiles VER Published less abundant. However, different data sets managed emerging
Topotecan 119413-54-6 of histone proteins complexed with DNA could increase the accessibility
secondary target is the topoisomerase class of enzymes, which are validated targets for many small molecule inhibitors including clinically useful anthracyclines such as doxorubicin and daunomycin or daunorubicin and camptothecins such as irinotecan and topotecan.34 Topo inhibitors elicit anticancer activities primarily by stabilizing the DNAnzyme cleavable complex through intercalation between Topotecan 119413-54-6 DNA base pairs. Topotecan 119413-54-6 chemical structureHowever, DNA does not exist as a naked structure in the nucleus. It is noncovalently associated withhistones to form the nucleosomes which make up chromatin subunits. Agents, such as HDACi, that induce hyperacetylation of histone proteins complexed with DNA could increase the accessibility of DNA within chromatin and consequently potentiate the anticancer activities of Topo inhibitors.
35,36 Moreover, recent observations have shown that HDAC1, HDAC2, and Topo II colocalize in vivo as part of functionally coupled complexes.37,38 These evidence suggest simultaneous Topo and HDAC inhibition could be a viable alternative Belinostat PX105684 approach in cancer therapy. We disclose herein small molecules with dual acting Topo IIDAC inhibitory activities. We found that many of these conjugates more potently inhibited HDAC and Topo II activities compared to SAHA and daunomycin, standard HDACi and Topo II inhibitors, respectively. Additionally, a subset of these compounds exhibited potent whole cell antiproliferative activities against representative breast, lung, and prostate cell lines.RESULTS AND DISCUSSION Design Rationale.
Anthracyclines are one of the most thoroughly studied classes of anticancer agents with copious structurectivity relationship data to aid the design and characterization of new anthracycline containing compounds. 394 axitinib Specifically, N benzylated anthracyclines, such as N benzyl doxorubicin 42, have enhanced Topo II inhibitory activities, reduced cardiotoxicity activity, and reduced susceptibility to the Pgp mediated multidrug resistance.457 We postulated that introduction of the HDACi via N benzylation of the DAU amino group would be compatible with Topo II inhibition and possibly engender the positive attributes of N benzylated anthracyclines to the resulting conjugates. In turn, the anthracycline moiety could serve two other purposes: as a surface recognition cap group, allowing favorable orientation of hydroxamic acid within the zinc binding pocket of HDAC, and as a delivery vehicle, because the transport of the anthracycline via proteasome could facilitate nuclear accumulation of HDACi.
43 On the basis of the forgoing, we designed two classes of conjugates: a direct DAUAHA conjugate and DAUriazolylaryl hydroxamate conjugates. The later conjugates were inspired by our previous studies which revealed that triazole moiety could be incorporated in lieu of amide bond as a surface recognition connecting group in prototypical HDACi.48 Chemistry. Crucial to the successful synthesis of all the conjugates described in this report is the reductive amination reaction between DAU and appropriate aldehyde intermediates 5 and 10a. Synthesis of aldehyde intermediate 5 started with the coupling of 4 aminobenzyl alcohol 1 to suberic anhydride 2 to give benzyl alcohol 3. To assess the suitable oxidizing agent for conversion of alcohol 3 t
BRL-15572 is important to note that when researching adherence with medication
l healthy. In this instance, counselling can be offered as appropriate. Adherence with medication can also BRL-15572 be adversely influenced by financial commitments. In the USA, the cost of medicines is a key concern with many women having difficulties purchasing their medicines. Limitations of this review are noted. It is important to note that when researching adherence with medication, one needs to consider that in clinical trial data reported rates of adherence may be higher than those reported in clinical settings and contribute to therapeutic failure. The studies included in the review employed a variety of research designs, the cohort study approach was the most common design used and time scales varied from 1 to 5 years. The shorter time scales may provide an inaccurate picture of adherence history.
Data collection approaches differed, and included questionnaire, medical records and self report measures. The efficiency of these data collection approaches have drawbacks of poor response rates, retrospective and possibly incomplete accounts of records, and possible overestimations of adherence rates. Only Lash et al. attempted to triangulate the results using both questionnaire and interview approaches to authenticate the data. Although there is no gold standard approach to measure adherence, studies should employ a combination of data collection measures to provide an accurate assessment of adherence patterns.
In addition, there is also a need to examine the impact of social factors that may adversely influence adherence such as the time required by medical professionals to adequately explain important drug regimens to women, the significance of the use of language during consultations and the impact of poverty, time management and social pressures and how they influence adherence with medication. It is also important to review the profile of women most likely to not adhere to adjuvant therapy. Research to date suggests that older women can be segmented in relation to adherence patterns. Women with poorer adherence rates tend to be aged 55 64 years and 5 years with ER positive breast cancer. Even though women aged 75 years are more likely to have good emotional health, may report less drug related side effects and maysymptoms. These symptoms are reported mostly around the ages of 50 59 years, and often improve during the use of hormone replacement therapy.
These symptoms are also frequently seen in breast cancer patients receiving adjuvant aromatase inhibitors. A number of clinical trials of AIs have reported musculoskeletal symptoms that include joint pain, joint stiffness, bone pain, muscle pain, and muscle weakness, with incidences ranging from 5% to 36%, but incidences were also high in the non AI arms. Arthralgia is considered a class effect of AIs, with an incidence 2 8% higher in patients treated with AIs than among those treated with tamoxifen in blinded controlled randomized trials. The exact mechanism of AI related arthralgia is unclear, but is believed to be related to oestrogen deprivation. It has been suggested that arthralgia/musculoskeletal symptoms in breast cancer patients on AIs could be a result of low levels of vitamin D. Several studies have shown that a serum vitamin D level of at least 20 ng/ml is necessary to minimal
AS-1404 Vascular Disrupting Agent inhibitor identified during tuberculosis contact tracing who did not receive
eria is not entirely clear. What is the risk for the development of AS-1404 Vascular Disrupting Agent inhibitor tuberculosis in an individual with latent infection with M. tuberculosis? Among individuals with positive tuberculin skin test results identified during tuberculosis contact tracing who did not receive preventive chemotherapy, approximately will develop active disease in the firstyrs. The risk of tuberculosis may be substantially higher in individuals identified by a positive IGRA tests result, but conclusive data are still missing. The disease risk among test positive persons is likely to be much lower in absence of recent contact exposure. It is also heavily influenced by age and other host factors. Tuberculosis is an old infectious disease. Despite the availability of chemotherapy against the tubercle bacillus, our battle with this old human enemy is still far from over.
With the rather unusual biological characteristics of this pathogen, the disease shows a distinctive natural historyand a very slow response to existing chemotherapeutic agents. Poor treatment adherence, acquired drug resistance, treatment failure and relapse have been encountered wee1 kinase since the early days of chemotherapy. A series of landmark trials in Madras,Africa, Hong Kong and Singapore helped to establish the currently adoptedmonth standard regimens given under supervision.These studies laid the foundation for the global comprehensive strategy for TB control known as directly observed treatment, short course, which was promulgated inby the World Health Organization alongside a declaration of TB as a global emergency.
Despite some recent controversies over the exact role of the act of directly observed treatment,e no alternative method of drug administration has been conclusively shown to offer a similarly high rate of treatment success as that demonstrated by DOTS under functional programme settings.e Intermittent drug delivery either throughout the entiremonth course or only during the continuation phase in the lastmonths has been widely adopted to facilitate treatment supervision on an outpatient basis ever since the introduction of DOTS. The lower number of treatment visits helps to reduce both operational and patient related costs, especially if long travelling distances are involved. As intermittent treatment poses lesser interference on usual lifestyles, patients can carry on their regular daily activities and work.
This helps to promote access to care and treatment adherence by patients, especially in resource limited areas or for underprivileged segments of populations. In vitro demonstration of the post antibiotic effect has provided the scientific basis for intermittent TB treatment in clinical settings by showing that exposure to drugs, especially isoniazid, for a few hours resulted in suppression of mycobacterial growth for several days.e For rifampicin and possibly other TB drugs, free peak drug concentration to minimum inhibitory concentration ratio best correlates with the PAE and suppression of resistance. The PAE has also been suggested by animal studies. A series of guinea pig experiments have shown that, when the same total drug amount is given as a single dose or fractionated into multiple doses of different sizes, better efficacy is observed with high doses given at long intervals,


text:
Otok Šarengrad (srbohrvaško: Šarengradska ada / Шаренградска ада) je rečni otok na reki Donavi, ki leži na hrvaški-srbski meji, čez hrvaško vas Šarengrad. Zajema površino 9 km2 (3,5 kvadratnih milj). Otok je del širšega spora o meji med Hrvaško in Srbijo glede razmejitve obeh držav ob Donavi.

Zgodovina
Stara struga reke Donave je zaradi močnega ovinka na tem območju povzročala težave plovbi. Da bi rešila problem, je Avstro-Ogrska leta 1892 začela kopati kanal, ki bi poravnal tok reke. Po 17 letih je bil kanal Mohovo-Šarengrad leta 1909 dokončno dokončan in posledično je nastal otok Šarengrad. Na novo izkopani kanal bi se postopoma razširil in postal glavni tok reke, nekdanja struga pa bi postala anabranča. Tako so otok dejansko premaknili blizu levega brega, ki je sčasoma postal del Srbije.

V času Socialistične federativne republike Jugoslavije je bil otok del Socialistične republike Hrvaške.  Med hrvaško osamosvojitveno vojno sta otok zasedli JLA in srbska milica.

Badinterjev arbitražni odbor je menil, da bi moral meje med republikami postati meje med državami.

Leta 1998 so z Erdutskim sporazumom vzhodno Slavonijo, Baranjo in Zahodno Syrmijo ponovno integrirali s Hrvaško. Vendar pa je otok Šarengrad skupaj z otokom Vukovar ostal pod srbskim vojaškim nadzorom.

Leta 2002 je srbska vojska z otoka odprla ogenj na prefekti Vukovarsko-srijemske županije Nikolo Šaferja in njegovo spremstvo, ki je vključilo štiri otroke, ki je šel na sestanek s kolegom iz Srbije. Za to je bil ključni pogovor, da je imela stranka uradno soglasje srbskih uradnikov.

 Leta 2004 je Srbija z otoka umaknila vojsko, ki je nadomestila srbsko policijo. Vsak državljan Hrvaške se lahko približa otoku, ki prečka mejo Bačka Palanka - Ilok.  Zemljiškoknjižne knjige vodijo hrvaške oblasti, a srbska stran teh lastništev ne prizna. Leta 2009 je bil otok vzpostavljen začasne ureditve odprt za rekreacijske namene.

Hrvaški predsednik Ivo Josipović je februarja 2012 v izjavi za dnevni list Novi list dejal, da dve državi  potrebujeta prožno rešitev za mejne spore na Donavi, ki bi bila kombinacija rešitve, ki bi jo predlagali dve državi. Hrvaški predsednik je dejal, da je treba rešiti, kakršno koli sprejetje, dobro, če bi otok Vukovar sčasoma našli na hrvaški strani meje. Predsednik v svoji izjavi ni omenil drugega podonavskega otoka, otoka Šarengrad.

Sklici

Otoki Hrvaške
Sporna ozemlja

redpajama_set_name: RedPajamaWikipedia


text:
  <form name="createCommentForm"
  class="comment-form"
  ng-submit="createCommentCtrl.createComment()">

  <fieldset>

Show & Tell

    <textarea type="text"
    rows="3" cols="50"
    class="comment-box"
    autocorrect="on"
    autocomplete="on"
    placeholder="Tell Us About What You Found and Uplaod a Picture of It"
    uib-tooltip="Help find this Item with an informative Comment"
    tooltip-placement="bottom"
    tooltip-trigger="'mouseenter'"
    tooltip-enable="!inputModel"
    ng-model="createCommentCtrl.comment.message"
    required>
  </textarea>

</fieldset>

  Select a pic to upload

<button class="btn-std">Upload</button>
</form>

redpajama_set_name: RedPajamaGithub


text:
#import "FBUIAWebDriverAgent.h"

#import "FBAutomationTargetDelegate.h"
#import "FBUIAElementCache.h"
#import "FBUIAExceptionHandler.h"
#import "FBWDALogger.h"
#import "FBWebServer.h"

#import "UIAApplication.h"
#import "UIATarget.h"

@interface FBUIAWebDriverAgent ()
@property (atomic, strong, readwrite) id<UIATargetDelegate> automationDelegate;
@property (atomic, strong, readwrite) FBWebServer *server;
@end

@implementation FBUIAWebDriverAgent

+ (instancetype)sharedAgent
{
  static id agent;
  static dispatch_once_t onceToken;
  dispatch_once(&onceToken, ^{
    agent = [self.class new];
  });
  return agent;
}

- (void)start
{
  [FBWDALogger logFmt:@"Built at %s %s", __DATE__, __TIME__];
  self.automationDelegate = [[FBAutomationTargetDelegate alloc] init];
  [[UIATarget localTarget] setDelegate:self.automationDelegate];
  self.server = [[FBWebServer alloc] init];
  self.server.exceptionHandler = [FBUIAExceptionHandler new];
  [self.server startServing];
  [[NSRunLoop mainRunLoop] run];
}

@end


Joint history textbooks will set our intellectual comfort zone free of prejudices, and give us wings to fly where the future leads us!
One of my favorite subjects, throughout education, was history. The most important message this subject has transcended to me lies in the essence of warning us not to repeat mistakes. Nevertheless, each country in the Balkans, through their history books justifies and often glorifies its acts, while mistakes, if there ever were any, are mainly prescribed as something to blame others for. In fact, when I decided to combine books from different countries and read about the same topics, my belief of history as an unbiased subject slightly changed. Eventually, this small analytical approach of mine led me to the conclusion that, unfortunately, the obvious different angles and contradictory information, in most cases is dependent on the author`s belonging to the certain interest group.
I recently participated in a ten-day peacebuilding training organized by the Center for Nonviolent Action in Ulcinj, Montenegro. During the event, I gathered many insights and conclusions, but I was especially motivated and encouraged by a workshop where the role of prejudice and its historical development was in the focus. As the discussion was very simulative, it led me to have some flashbacks from school, as many of the topics were based on the materials we read while students. This workshop was a trigger that made me think of the subject of History, as it is my favorite subject but the same is valid for other subjects.
Being from Montenegro, whenever I travel abroad I am always asked about the Balkans. I am always taken aback as its history and politics are very complicated to explain. Thus, I always wondered, if I had a subject in school that helped me understand it better, I would have a clearer understanding and answer. Joint history textbooks will help the region to break free from impetuses leading to conflicts and will help us, the youth, think of the future in a clearer sense.
Could the establishment of joint history textbooks be the way of dismantling prejudices that are shaping social interaction in the Balkans and as such, our future as a region? A possible example of how we could manage this heavy remanence of the past is given by many enlightened individuals, with whom the process which leads to permanent change begins. The enlightenment, however, flows out of a good educational system that could influence the perception of individuals of certain information, therefore, being a precious channel through which we can benefit intellectually and spiritually, leaving prejudices stemming from ignorance far away from us.
Only when we all learn from joint history textbooks we, the youth of the region, would be able to move forward and make decisions based on the pragmatic information. Education is the power that will contribute to breaking down barriers and directing us to a stronger and more developed region!


There is a vast and deep sea of wedding suppliers in the Yorkshire region and surrounding areas. Trying to decipher which ones are good, which ones are poor, and which ones are excellent can be time consuming and most of all confusing.
We don't just love introducing our couples to the perfect partners, we know it is essential in ensuring your wedding day is exactly as you want it to be.
If you came to this page to find out who our perfect partners are, then you may be a little disappointed – this is a privilege saved for our clients. If you are really stuck however, finding the perfect supplier for your wedding, make sure you give us a call – we still like sharing the love where we can!


text:
Kiera Aston Deadlifts Massive 247.5 kg (546 lbs) For Three Reps in Training
The IFBB Pro bodybuilder and a U75 kg powerlifter Kiera Aston, published some snippets of her deadlift session on her Instagram account, with the most impressive being her three reps with 247.5 kg (546 lbs). Kiera is famous for her deadlift abilities, so this is not the first time that Kiera deadlifts this much weight, but it is certainly very impressive.
Kiera published 3 sets of deadlifts, with the first one being 3x 247.5 kg (546 lbs), followed by the second set of 2 reps with the same weight. Furthermore, Kiera managed to deadlift 210 kg (463 lbs) for 8 reps. She used a lifting belt and lifting straps, with a conventional stance.
You can watch the video here:
Related: Kiera Aston Annihilates 240kg Deadlift For 5 Reps Like It Is Nothing
Kiera pointed out in the comments that her current weight is 79.5 kg. This would mean that Kiera deadlifted just over 3x her bodyweight.
Kiera Aston's Greatest Achievements
Kiera's greatest achievement is becoming the youngest IFBB pro bodybuilder in Europe. She then discovered her potential in powerlifting and realized how strong she is. Not to be neglected, one of her biggest achievements is her 4-year body transformation, as she has made some tremendous progress after taking up bodybuilding and powerlifting.
You can see her transformation here:
Even some of the most famous fitness figures have recognized the strength that Kiera possesses, including one of the strongest people on earth, Larry Wheels. Larry featured Kiera on his YouTube channel, where they did a heavy squat session.
Related: Kiera Aston Smashes Through Huge 573lb Stiff Bar Deadlift With Ease
Kiera Aston is really a freak of nature, and excels in everything she decides to do. She is still very young and further improvement is almost guaranteed. Kiera revealed that she is planning to come down to 75 kg bodyweight for a powerlifting competition, but she did not reveal the name of the competition. It's unclear when she will be stepping on stage next for the bodybuilding competition.
Kiera Aston kiera aston deadlifts 546 lbs Kiera Aston Deadlifts Massive 247.5 kg Kiera Aston Deadlifts Massive 247.5 kg For Three Reps in Training News Powerlifting

redpajama_set_name: RedPajamaCommonCrawl


As a perfect drills, 1/2″ drill model dp4000. *powerful 7 amp motor for heavy duty industrial performance. *variable speed (0-900 rpm) for drilling in a wide variety of materials. *retractable belt clip allows operation in tight areas. *lightweight cast aluminum gear housing for durability. *ergonomically designed rubber grips for positive control. *large trigger switch is conveniently located. *comfortable side handle rotates 360 degrees. *all ball and needle bearing construction for long tool life. *brushes are easily accessible for easy replacement. double insulated.
This makita dp4000 7 amp 1/2-inch drill fit for you who want drill driver with powerful 7.0 amp motor for heavy duty industrial performance. variable speed (0-900 rpm) for drilling in a wide variety of materials. lightweight aluminum gear housing for durability. retractable belt clip allows operation in tight areas. ergonomically designed rubberized grips for comfortable operation. large trigger switch is conveniently located. side handle rotates 360° for comfort and control. all-ball and needle bearing construction for longer tool life. easily accessible brushes for greater serviceability. double insulated. drill chuck (193229-6). chuck key (763430-3). side handle (134903-7). ds4011. da6301. da3010f. ds4000. da4000lr. da4031. dp4002. 6408. 6407. powerful 7 amp motor for heavy duty industrial performance. variable speed (0 – 900 rpm) for drilling in a wide variety of materials. retractable belt clip allows operation in tight areas. ergonomically designed rubberized grips for positive control. large trigger switch is conveniently located.
It will most comfortable and better to get this makita drill after get an opportunity to read how real purchaser felt about ordering this drill drivers. During the time of publishing this makita dp4000 7 amp 1/2-inch drill review, there have been more than 12 reviews on this link. Most of the reviews were very pleased and we give rating 4.8 from 5 for this makita dp4000 7 amp 1/2-inch drill. Reviews by individuals who have take on board this makita dp4000 amp 2 inch drill are useful enlightenment to make decisions.


text:
[ $# -ne 0 ] || set -x		# debug mode without arguments:-)

THERE="`echo $0 | sed -e 's|[^/]*$||' 2>/dev/null`.."
[ -d "${THERE}" ] || exec "$@"	# should never happen...

# Alternative to this is to parse ${THERE}/Makefile...
LIBCRYPTOSO="${THERE}/libcrypto.so"
if [ -f "$LIBCRYPTOSO" ]; then
    while [ -h "$LIBCRYPTOSO" ]; do
	LIBCRYPTOSO="${THERE}/`ls -l "$LIBCRYPTOSO" | sed -e 's|.*\-> ||'`"
    done
    SOSUFFIX=`echo ${LIBCRYPTOSO} | sed -e 's|.*\.so||' 2>/dev/null`
    LIBSSLSO="${THERE}/libssl.so${SOSUFFIX}"
fi

SYSNAME=`(uname -s) 2>/dev/null`;
case "$SYSNAME" in
SunOS|IRIX*)
	# SunOS and IRIX run-time linkers evaluate alternative
	# variables depending on target ABI...
	rld_var=LD_LIBRARY_PATH
	case "`(/usr/bin/file "$LIBCRYPTOSO") 2>/dev/null`" in
	*ELF\ 64*SPARC*|*ELF\ 64*AMD64*)
		[ -n "$LD_LIBRARY_PATH_64" ] && rld_var=LD_LIBRARY_PATH_64
		LD_PRELOAD_64="$LIBCRYPTOSO $LIBSSLSO"; export LD_PRELOAD_64
		preload_var=LD_PRELOAD_64
		;;
	# Why are newly built .so's preloaded anyway? Because run-time
	# .so lookup path embedded into application takes precedence
	# over LD_LIBRARY_PATH and as result application ends up linking
	# to previously installed .so's. On IRIX instead of preloading
	# newly built .so's we trick run-time linker to fail to find
	# the installed .so by setting _RLD_ROOT variable.
	*ELF\ 32*MIPS*)
		#_RLD_LIST="$LIBCRYPTOSO:$LIBSSLSO:DEFAULT"; export _RLD_LIST
		_RLD_ROOT=/no/such/dir; export _RLD_ROOT
		eval $rld_var=\"/usr/lib'${'$rld_var':+:$'$rld_var'}'\"
		preload_var=_RLD_LIST
		;;
	*ELF\ N32*MIPS*)
		[ -n "$LD_LIBRARYN32_PATH" ] && rld_var=LD_LIBRARYN32_PATH
		#_RLDN32_LIST="$LIBCRYPTOSO:$LIBSSLSO:DEFAULT"; export _RLDN32_LIST
		_RLDN32_ROOT=/no/such/dir; export _RLDN32_ROOT
		eval $rld_var=\"/usr/lib32'${'$rld_var':+:$'$rld_var'}'\"
		preload_var=_RLDN32_LIST
		;;
	*ELF\ 64*MIPS*)
		[ -n "$LD_LIBRARY64_PATH"  ] && rld_var=LD_LIBRARY64_PATH
		#_RLD64_LIST="$LIBCRYPTOSO:$LIBSSLSO:DEFAULT"; export _RLD64_LIST
		_RLD64_ROOT=/no/such/dir; export _RLD64_ROOT
		eval $rld_var=\"/usr/lib64'${'$rld_var':+:$'$rld_var'}'\"
		preload_var=_RLD64_LIST
		;;
	esac
	eval $rld_var=\"${THERE}'${'$rld_var':+:$'$rld_var'}'\"; export $rld_var
	unset rld_var
	;;
*)	LD_LIBRARY_PATH="${THERE}:$LD_LIBRARY_PATH"	# Linux, ELF HP-UX
	DYLD_LIBRARY_PATH="${THERE}:$DYLD_LIBRARY_PATH"	# MacOS X
	SHLIB_PATH="${THERE}:$SHLIB_PATH"		# legacy HP-UX
	LIBPATH="${THERE}:$LIBPATH"			# AIX, OS/2
	export LD_LIBRARY_PATH DYLD_LIBRARY_PATH SHLIB_PATH LIBPATH
	# Even though $PATH is adjusted [for Windows sake], it doesn't
	# necessarily does the trick. Trouble is that with introduction
	# of SafeDllSearchMode in XP/2003 it's more appropriate to copy
	# .DLLs in vicinity of executable, which is done elsewhere...
	if [ "$OSTYPE" != msdosdjgpp ]; then
		PATH="${THERE}:$PATH"; export PATH
	fi
	;;
esac

if [ -f "$LIBCRYPTOSO" -a -z "$preload_var" ]; then
	# Following three lines are major excuse for isolating them into
	# this wrapper script. Original reason for setting LD_PRELOAD
	# was to make it possible to pass 'make test' when user linked
	# with -rpath pointing to previous version installation. Wrapping
	# it into a script makes it possible to do so on multi-ABI
	# platforms.
	case "$SYSNAME" in
	*BSD|QNX)	LD_PRELOAD="$LIBCRYPTOSO:$LIBSSLSO" ;;	# *BSD, QNX
	*)	LD_PRELOAD="$LIBCRYPTOSO $LIBSSLSO" ;;	# SunOS, Linux, ELF HP-UX
	esac
	_RLD_LIST="$LIBCRYPTOSO:$LIBSSLSO:DEFAULT"	# Tru64, o32 IRIX
	DYLD_INSERT_LIBRARIES="$LIBCRYPTOSO:$LIBSSLSO"	# MacOS X
	export LD_PRELOAD _RLD_LIST DYLD_INSERT_LIBRARIES
fi

cmd="$1${EXE_EXT}"
shift
if [ $# -eq 0 ]; then
	exec "$cmd"	# old sh, such as Tru64 4.x, fails to expand empty "$@"
else
	exec "$cmd" "$@"
fi


text:
Spare a Jackson?
"Spare a Jackson?"
Last night rioters tried to pull down a statue of the 7th president of the United States, Andrew Jackson. I wonder if they knew that he had single-handedly defeated the British at the Battle of New Orleans in 1815. Or, that he'd paid Black soldiers equal pay to Whites (quite ahead of his time). Or, that Andrew Jackson adopted a Native American boy whose mother was killed on the battlefield when no other Native American would take the boy, Lycoya. What is the criteria for desecrating and removing historical monuments? If the answer is racism, please spare Andrew Jackson. There's a reason why he's celebrated throughout this country and has his name honored in so many places, and it's not due to his hatred of other races. If the answer is that he is old and white, then by all means (that sounds racist). If the criteria is to remove all historical record of any imperfect people, then we have a lot of books to burn today. History matters and children need to be taught this. Without Andrew Jackson, all of the mob mentality rioters would surely and angrily be exhaling British air.
Follow our Cypress-Jersey Village-Jones Rd. blog: https://eternalmartialartshouston.com/blog


text:
Meet Our Businesses
Nicolet-Wolf River Scenic Byway Awarded Tourism Marketing Grant
The Wisconsin Department of Tourism recently notified the Forest County Economic Development Partnership of its award of a Joint Effort Marketing (JEM) grant for the "Fall in Love With the Byway" promotion.
An official award will be made by the Department of Tourism in August, and the campaign officially kicks off on September 4, 2018.
The Fall in Love With the Byway promotion is a cooperative effort between Langlade, Forest, Oneida and Vilas counties to promote the Nicolet-Wolf River Scenic Byway. The Nicolet-Wolf River Scenic Byway was designated as the state's fifth, and final, scenic byway on August 22, 2017.
The JEM grant will provide marketing dollars for the group to collectively promote the Nicolet-Wolf River Scenic Byway in a fall promotion that will begin September 4 and continue through October 31, 2018. The JEM award totals $38,633, and the group will contribute matching funds of $42,597, for a total promotional budget of $81,230.
"We will work cooperatively with the four county destination marketing organizations, including the chambers of commerce and regional tourism entities, to share social media and website promotions, insuring our reach is including all the businesses, historical, cultural, recreational and natural resources that may be found along the Byway," Mark Ferris, Forest County Economic Development Partnership Executive Director, said.
"This promotion encompasses four counties that regularly work together to collective promote our communities. Through our collaborations, we have identified demographics that visit all four counties, and we look forward to showcasing the Byway to visitors," Melinda Otto, Forest County Chamber Executive Director, said.
The marketing budget will focus on social media, search engine optimization, online newspaper advertising in the Fox Valley and Milwaukee areas, radio marketing in the Fox Valley and Milwaukee areas, and statewide sponsorships with Wisconsin Public Radio.
Area townships, county board supervisors and local businesses endorsed the JEM grant application, providing letters of support as part of the application.
"We look forward to working cooperatively with our regional tourism partners to increase awareness of the Nicolet-Wolf River Scenic Byway, and to increase the numbers of visitors to our areas," Ferris continued.
The promotion includes pre- and post-surveys to businesses along the Scenic Byway to share with visitors. Businesses should expect to receive their pre-surveys by the end of June, and the post-survey in November
Copyright © 2021 Nicolet-Wolf River Scenic Byway
Championed by Kim Swisher Communications, LLC.


A wedding cake is—quite literally—the icing on an amazing day. Make yours deliciously special by honoring your family heritage or the flavors of a favorite place. Here, we reimagined five traditional confections from around the globe. Dessert is served!
As far back as 1685, the British served "bride's pye," a large, round pastry filled with pine kernels, sweetbreads, oysters, spices, and lamb stones (you don't want to know). One hundred years later, as preserved fruits replaced the savory filling, the pie evolved into the fruitcake, a symbol of fertility and prosperity. Our reinvention mixes dried fruits, almonds, and pecans into the batter. The cooled cake is brushed with a sugar-brandy syrup and covered with almond-flavored fondant and white marzipan accents.
More delicate and aromatic than their European counterparts, Japanese sweets often reinterpret Western desserts using popular Japanese flavors. We added white peach, green tea, and cherry blossom extracts to traditional Japanese sponge cake. The mini treats, perched atop rice paper–lined lids from balsam wood craft boxes, feature a paper band stamped with the Japanese character for love. Gum-paste decorations indicate the peach and cherry-blossom cakes; the bunny and pig, both green-tea flavored, represent the Chinese zodiac signs of the couple's birth years.
Rare is the Norwegian or Danish couple that says "I do" without serving a kransekake, which means "wreath cake." The tasty tower has been around since the 1700s and consists of concentric rings of marzipan biscuit topped with party crackers or flags. The bride and groom pull off the top rings with their hands in a customary scandinavian ring-breaking ceremony; the number of layers still attached predicts how many kids they'll have. Our kransekake makes a modern statement with intricate royal-icing piping inspired by Northern European folk patterns and a duo of wood-paper lovebird-flag toppers.
The centuries-old Italian wedding cake called millefoglie ("a thousand layers") contains endless tiers of puff pastry, pastry cream, and fresh fruit that result in a perfect storm of scrumptiousness. Our rustic take on the cake injects a little zing without sacrificing authenticity. We added tangy lemon to the filling and replaced the traditional strawberries with ripe red currants and juicy raspberries, just right for a summer soirée.
The origins of Mexico's tres leches cake, baked with three kinds of milk, may be disputed. Some say it came to Latin America via European colonists and was popularized when Nestlé printed the recipe on condensed-milk cans in the 1960s. Others say it started south of the border. But one thing is certain: offer this on your big day and you'll hear "muchas gracias." This recipe has a tropical twist, infused with passion fruit and finished with whipped cream frosting.


Three-way lookup between English, Hungarian, and Romanian.
Transylvania Calling / Gathering of the Tribes / Romania.
Romania tours. Tours and Vacations in Romania. Transylvania Travel Guide. Customized Tours, Dracul Tour. Castel's Tours. Unseco Tour. Bucharest Tours.


18K Spread! Premium LED Lights! LOADED!
Other Dealer or Manufacturer in Inventory, Sales and Service!
Owner Direct! We are Located in The Dallas-Ft. Worth Texas Area!
Wacobill.com Can Finance your Dream Trailer Today!
DISCLAIMER: All advertised prices are Cash-in-Person/ No Delivery.
Advertised Cash Price. We Reserve the Right to Deem "What is Cash".
TradesAccepted: Cash-in-Person/ No Delivery/ No Installs. Thank You.
Cash-in-Person/ No Delivery/ No Installs. Thank You.
FAST CASH FOR YOUR RACE TRAILER!


navy blue kitchen navy blue kitchen cabinets kitchen rustic kitchen with navy blue cabinets rustic kitchen with navy blue navy blue farmhouse kitchen decor.
navy blue kitchen blue kitchen decor blue kitchen decor light blue kitchen walls medium size of kitchen blue kitchen navy blue country kitchen curtains.
navy blue kitchen navy blue kitchen i know if ill have the guts to put navy cabinets in my house but it may be worth combining with gray navy blue kitchen cabinets for sale.
navy blue kitchen navy blue kitchen cabinets navy kitchen cabinets navy white kitchen reveal navy blue kitchen ideas dark navy blue kitchen navy blue kitchen accessories.
navy blue kitchen navy blue kitchen decor navy blue kitchen decor navy kitchen walls white kitchen cabinet ideas kitchen navy blue kitchen cafe curtains.
navy blue kitchen dark blue cabinets navy blue kitchen cabinet dark blue modern kitchen with white navy blue kitchen dark blue cabinets beautiful kitchen solid navy blue kitchen curtains.
navy blue kitchen full size of charming navy blue kitchen ideas navy blue kitchen accents best navy blue kitchen cabinets.
navy blue kitchen navy blue kitchen cabinets black and white tile floor and gold cabinet hardware navy blue kitchen cupboard paint.
navy blue kitchen navy blue kitchen cabinets navy blue kitchen walls white cabinets.
navy blue kitchen blue kitchen ideas dark blue cabinets navy blue cabinet pulls dark blue kitchen cabinets lovely ideas blue kitchen navy blue kitchen cabinets with black granite.
navy blue kitchen navy kitchen walls navy blue kitchen walls with white cabinets navy blue kitchen cabinets navy blue navy blue kitchen containers.
navy blue kitchen navy blue kitchen cabinet color raccoon fur coastal living cottage design ideas and paint colors navy blue kitchen tools.
navy blue kitchen navy blue kitchen navy blue kitchen cabinets ideas navy blue kitchen cabinets navy blue kitchen navy navy blue kitchen navy blue kitchen cabinets brass hardware.
navy blue kitchen navy blue kitchen cabinets navy kitchen cabinets trendy awesome white and blue kitchen cabinets simple interior navy blue kitchen navy blue kitchen chairs.
navy blue kitchen navy blue kitchen solid navy blue kitchen rugs.
navy blue kitchen navy blue kitchen navy blue kitchen island navy blue kitchen island with home appetizer ideas navy navy blue kitchen navy blue kitchen utensils.
navy blue kitchen dark blue kitchen cabinets navy blue kitchen cabinets navy blue and grey kitchen full size of dark blue kitchen navy blue and white kitchen accessories.
navy blue kitchen navy navy blue kitchen designs.
navy blue kitchen dark blue kitchen cabinets going dark navy blue bar dark brown color kitchen cabinets navy blue kitchen rugs.
navy blue kitchen blue kitchen walls blue kitchen walls navy blue kitchen walls light blue kitchen walls oak cabinets navy blue country kitchen curtains.
navy blue kitchen blue cabinets kitchen grey luxury cabinet dark navy navy blue kitchen cabinets brass hardware.
navy blue kitchen navy blue kitchen cabinets with brushed brass pulls and white marble like navy blue kitchen walls with oak cabinets.
navy blue kitchen proving no such thing as too much blue this breezy kitchen layers in sky navy blue and yellow kitchen decor.
navy blue kitchen blue kitchen island navy blue kitchen island navy blue island navy blue kitchen island for sale navy blue plaid kitchen curtains.
navy blue kitchen blue kitchen island navy blue kitchen island white kitchen with blue island home interiors and gifts navy blue kitchen canister set.


I'm CRAZY excited. Like for real weirdly excited to share this with you today. I want you to understand how LIFE-CHANGING this could be for us all.
Think for a second about the amount of time you spend at the grocery story a week. I probably spend 1 1/2 to 2 hours....depending on what we need. I make a BIG trip once a week to get everything and then usually I have to go for a smaller trip later. That is ALL about to change.
Well, have you heard of Wal-Mart Grocery Pick-Up?
I got to experience this on Tuesday and for real-my weekly grocery shopping will never be the same.
*You can go HERE to create an account. This is also where you'll be able tell if they offer it in your area. The closest Wal-Mart to me does not offer this service, but in my opinion it was worth the drive!
*After you've created an account, you can begin shopping. I found the quickest way for me to shop was just to type in the search bar exactly what I was looking for. Instead of clicking on "Dairy" and scrolling through until I found cream cheese it was much faster to type in "cream cheese".
*Overall, it did NOT take me a long time to "shop". I did it while I was making my grocery list. You pay right then when you're ready to check out online.
*You also select your pick-up time. Please note that it cannot be the same day. Or at least it couldn't be in my case. Just know you need to "shop" at least the day before. The choices are all two hour time slots for pick up.
*You'll get a call about thirty minutes before your pick up time begins. The sweet worker asked what time I thought I'd be there. Just so they have a better idea.
*You pull up and they load your car with your goodies. YOU DON'T EVEN HAVE TO GET OUT OF THE CAR!! I'm gonna repeat that because I think it's important...YOU DON'T EVEN HAVE TO GET OUT OF YOUR CAR! I might have sprinted out of my car to shake the worker's hand because I was so excited about this. But...I was informed that next time I can stay in my car. haha!
*There is NO fee!!! It's completely FREE!!
I drive by two other grocery stores to get to the closest Wal-Mart, so to be honest usually I don't go to Wal-Mart for groceries. But with this program that will change. I do think in the future I'll get my meat and produce on a quick trip to my closest grocery store. I learned that I like being able to choose my meat and produce. Then I'll stock up on everything else with this service from Wal-Mart.
Did I mention paper towels and kids' shampoo were also a part of my last trip? It doesn't have to be JUST groceries.
And...I SAVED money! There's no adding things to your cart as you walk by. I ONLY came home with the things on my list!
There were a couple items I had chosen that were out of stock, so this is what they do in that situation...they get something similar if they have it (organic celery instead of regular celery) or maybe a different brand if one brand is all sold out. They do ask you about all those changes when they deliver your groceries. You have the choice to decline.
For real!! Grocery shopping is one of my least favorite things, so this is a game changer for me!
I did this yesterday and it was awesome! I was very happy with my produce. I don't buy meat from Walmart so I still go to Kroger/Costco but for everything else I'll be doing Walmart! Merry Christmas!
LIFE. CHANGING. You can spend all of that extra time you are going to have eating tacos with me!
Erika! I mean...I can not even begin to explain how excited I am about this! I'm trying it out tomorrow friend!!!! Woohooooooooo!
I had another friend tell me about this and I thought it was too good to be true! I'm definitely trying it out now!
This is life changing for all of the busy mamas!!! Love it!!
So jealous! Kroger does this as well...do you all have Kroger down there? Anyway, no Krogers or Walmarts by me do it (in Illinois) but I so wish they did!
We have had that the past year at our Iowa grocery store, Hy-Vee and it seriously IS life-changing! I sometimes can't even believe I just pull up and they LOAD them for me! Now I will wait for Walmart to do it here and when Costco starts this program, I will be SET!!!
Our Walmart doesn't offer this but a grocery store chain in our town does. My mother in law gifted me the service (it's 99.95 a year here). It has been a life changer!! I have four kids and I have no idea why I hadn't signed up earlier. Usually I will shop online at night and pick it up the next day on our way home from preschool.
I live near Bentonville (close to walmart home office) and our stores have had this option for a couple of months! It's so awesome!! When you purchase produce items (even eggs), the employee will show you what they have selected and you have the option to have it removed if it isn't to your liking. I'm picky about things like bananas and tomatoes, but for things like celery, carrots, or potatoes, it was really nice! It's also nice for bottled water/drinks and paper goods! I highly suggest it to anyone thinking about trying it.
Harris Teeter in Virginia does this! It's awesome!! They do charge $4.95 but there are ways to get it waived. I figure I save more than that by not making impulse buys!
How awesome that Walmart does this now! For about a year now our grocery stores have been doing this, but I didn't not realize that Walmart did it! Defiantly going to check and see if my local Walmart does it!
Erica -Isn't this just amazing? I've been using this service for about a month now and it is LIFE changing. It had to have been created by a mom!
Glad you are using it too!! Head y'all had so much fun at your party Tuesday night!!!
Our grocery store here in Iowa (Hy-Vee) does this but they deliver it to YOUR FRONT DOOR. Amazing. We just shop online, select everything, add it to the cart, put in coupon codes, and then select a date/time for delivery! It is a $5 fee but that's a flat fee whether you spend $10 or $200 on groceries! SO WORTH IT.
I tried it last month - and blogged about my experience. I REALLY wanted to like it...but I ended up going back for things they didn't have, I didn't get the amount I thought I would or for meat and produce, because you just need to be able to see that stuff. I am so glad you had a good experience, maybe I will try again!
I need to do this!! Shopping with a 5 month old isn't too ideal, lol!! I never shop at Walmart though. If only Heb offered this!!
Hmm...town about 40 minutes away does this, but not my town. I may make the drive just so that my grocery trip involves kids watching iPads in the car and me sipping coffee rather than a fight in aisle 7 and sensible grocery shopping shoes! haha!
Giiirrlll, it IS life-changing! I don't do my grocery shopping at Wal-Mart (like you, I just can't do my meat and produce there and that's mostly what I buy) but luckily my local grocery store does this too and it's amaaazing!! It took me about a half hour the first time to set up my list and now it's just an easy click-click-click. I drive up, they load me up and I'm good to go... seriously, a HUGE deal!!
That's awesome. I don't have it in my area yet, but finger's crossed, it comes soon. If you're shopping there, you should also download the Walmart Savings Catcher app. You scan your receipt and not only does it store it in your phone for returns, but it compares all of your items' prices to stores around your area, and if it's found cheaper somewhere else, they give you the difference on a gift card on the app! I've gotten about $30 back over the past several months!
Can't wait to hear what you think!
Yes, we have Kroger but I haven't heard of it being offered in our area. I'll check on it though just to be sure. Thank you!
That is amazing! Wish Market Street would do this!
That is amazing!! And what a great gift!!
I completely agree!! I saved a ton!
So true!! Hahaha! Definitely a mom. Yes, it was so good to see Jeni! Can't wait to see what you do with that baby's room!
That is incredible!!! And definitely worth the $5!!!
Oh no!!! They didn't have one thing that I needed so I had to stop somewhere else but I just ran in to get that one thing so it wasn't a big deal.
That is awesome! I wish our grocery stores offered this too! Check it out and see if there's one near you.
I hear you!!! If only they would have done this when my kiddos were tiny! I'm gonna make up for it now! Haha!
That actually sounds super peaceful!! Haha! You should give it a shot!
So glad you mentioned that! I need to download that app!
I am a big Kroger shopper and they have just started doing this as well! It's not in my area yet, but I am praying it comes soon! I am single with no kids, but I live in a super snowy area and hate trying to push a shopping cart in the parking lot of snow!
If this is in your area you need to look in to Amazon Fresh. Oh it's 11 and you realized you're out of milk. Scan your empty milk carton, they send you a scanner, set a delivery window of 4 AM and you will get up and your milk will be sitting on your front porch! You can do your grocery shopping in your kitchen by scanning everything you need as it runs out and it gets saved to your cart! There is an annual fee for unlimited delivery but it's worth it!
That would definitely be a life changer and a budget changer...less time for me to find something I didn't already know I needed!
I love this idea especially during the Holidays.
HEB is doing it at select stores in the Houston area. I am going to try it ... now that I hear about Wal-Mart's services and your experiences!!
I live In Bentonville, AR (the home of Walmart) and they have tested this here for the last year and it is awesome! The first time I did it it took me a while online to select all my products but now I am really quick plus the website suggests items you have bought in the past . The associates are super friendly and our pick up location and they always ask if I want to look over my produce.
Our local grocery store (HyVee) has a similar program as well as an even better one. I live in Des Moines and HyVee has the same program you described above and they also have a program where they will deliver your groceries to you - for free! Totally taking advantage of that this winter after baby number 2 shows up and the thought of trying to leave my house in the dead of winter with 2 under 3 sounds awful.
I'm in Minnesota and there are several stores that deliver groceries. I do it anywhere from one to four times a month depending what I need and the one I use charges $5. Totally and completely worth it.
When I have babies, I can definitely see this as being a GREAT resource. Until then, I think I'll continue doing it myself. I just love grocery shopping, call me crazy!
I used this service at our local grocery store just this week. I don't do it every week but it sure is nice when you need it. Our service started out free but now there's a $2.95 service charge. Totally worth it to me!
i'm wondering if its maybe not a thing over there.. but for the last 18 months for £6 a month I have had every single weekly shop delivered to my door... I loathe grocery shopping to the point that I panic when i go inside a large store and I have also cut my grocery bill by 2/3 by ordering it online!
I didn't know this about Walmart, thanks for sharing this! I've always shopped for groceries at whole foods, because they offer this service too. Do you know if it include anything from Walmart? Or just groceries?
The grocery store (Giant) up here in PA has been doing that for a while. Recently they introduced PeaPod...they deliver the groceries to your house! I know a few people that use that and they love it! I'm fairly certain there is a small fee associated or at least a spending minimum.
Life.changing is right! I can.not.wait. for this to come to my area!
This service just came to our area and life changing is the exact word I use when telling people about it! Not having to load and unload the baby at the store is great and it helps the budget since I don't make impulse purchases.
Make sure you share your referral code with friends. You both save $ when they use it!
Catching up on blog reads & just saw this. I have to echo - life changing! I have been using this for about two months here in Alabama. Two weeks ago I had major surgery & a friend has been doing my grocery pickups. It has been a godsend! I just shop online & pay & she goes & picks it up the next morning & brings it to my house. I've already paid so it's less complicated. So awesome. Kudos to Walmart!


This graph depicts the the percentage of tickets sold at the Olympic Winter Games from 1988 to 2018. In 1988, 84 percent of available tickets were were sold.
Everything On "Winter Olympics 2018" in One Document: Edited and Divided into Handy Chapters. Including Detailed References.
Statistics on "Winter Olympics 2018"
How much have you heard about the 2018 Winter Olympics which will be held in PyeongChang, South Korea?Public awareness about the 2018 Winter Olympics U.S.
What are some of your favorite Winter Olympics events?
How much have you heard about the 2018 Winter Olympics which will be held in PyeongChang, South Korea?
How much of the Winter Olympic Games do you plan to watch?
If you could afford it, would you want to go see the Olympic Games in person in PyeongChang this year or not?
Through which of the following routes, if any, have you ever bought a resold ticket to a live event?


1- The revalidation of doctors' medical credentials is a practice in place in many countries. If Cuba believes that Brazil's intention was to question Cuban doctors' qualifications, why not, instead of withdrawing them, seize the opportunity to demonstrate their capacities to the world?
2- If Cuban doctors are fully identified with "revolutionary" principles, why are they subject to prolonged family separations, suffering all the negative consequences of such a measure?
3- Why is it unacceptable for Brazil to insist on full payment of their salaries, as is the case of doctors from other countries, instead of via the Pan American Health Organization (PAHO), through which the Cuban Government seizes 75% of their remuneration?
As the article "Havana's Lies: How Cuba covered up the salaries of Cuban doctors in Brazil and got the PAHO involved", published in the DDC, reveals, the sending of Cuban doctors to Brazil was discussed beginning in April of 2012, but the involvement of the PAHO was not even considered until December of that year, and was adopted as a subterfuge to elude the Brazilian Congress, which would have to be consulted in the event of bilateral agreement, and also to keep from tipping the trade balance to the Cuban side, which would have happened if Brazil had paid Havana directly for the doctors contracted.
4- If the doctors are those who best know the needs of that country, why weren't they allowed to decide for themselves whether to return or stay, and whey weren't they consulted before making the decision, or even informed before making it public?
5- Why are those who the Government withdraws called "heroes," but those who decide to continue offering their services in Brazil called "deserters?" And why are they barred from returning to their country for eight years?
6- If the Cuban government recognizes that the decision has an impact on the Brazilian people, how can it claim that the decision was taken in defense of the professional and human dignity of the collaborators, when they were not even consulted? This, while leaving millions of Brazilians without medical attention. What is more important: responding to an alleged attack on the doctors' dignity, or medical attention for those in need of it?
7- The export of professional services is the country's primary source of revenue. Medical services rank first, and the Más Medicos program is the main one, its closure meaning the loss of about 300 million dollars per year. How can "countering the offence" be preferable to renegotiating with Brazil?
8- If participation in the Program allows Cuban doctors to satisfy needs or realize aspirations impossible with the salary they receive in Cuba, and if Brazil will, in the future, open up positions for Cuban and foreign doctors, it was not difficult to deduce that many Cubans would never return, represent a considerable loss of qualified personnel on the Island. So, what is the advantage or the reason for withdrawing them, rather than negotiating?
First, in light of the fact that these medical services are exported by a State that is the doctors' sole employer, one that prohibits them from leaving the country without permission, and forbids their relatives from accompanying them, and pays them just 25% of what they are actually earning; and that, without physical forcing them, all but obliges them to go, out of necessity, it is evident that they have no power of decision, as demonstrated by the cancellation of the Más Médicos program. The Cuban policy is one of modern slavery.
Second, the revenues of a country cannot depend strategically on sources as fragile as the contracting of professionals, nor upon subsidies distributed for reasons of ideological affinity.
Third, all of the above is closely related to the existence and defense of an economic model that, unable to produce, has forced the regime to rely on subsidies, unpaid loans, and the export of professional services under conditions of modern slavery.
Fourth, a rigorous analysis reveals the unavoidable need for deep structural reforms, including citizens' freedoms, without which professionals will continue to be subjected to this kind of modern-day slavery, and the economy will collapse, as it is impossible to continue living on subsidies and the export of professionals' services, a fact ignored in the new Constitution drafted by the Communist Party.


Planet Salem: the international Salem Al Fakir fansite!: Rockbjörnen Live: two nominations....and Facebook's fabulous 50,000!
Rockbjörnen Live: two nominations....and Facebook's fabulous 50,000!
Great news today, as Salem has been nominated in two categories - Best Swedish Male Live Artist and Best Swedish Song of the Year ("Keep On Walking") in this year's Aftonbladet Rockbjörnen Live awards.
And even more great news today as the total number of fans at Salem's Facebook fan page reached the fabulous total of 50,000!
Welcome to the Planet Salem "family" - keep in touch!!
Thank you Laura for those nice words!
We certainly hear again soon!
Thanks for your kind words - hugs from me too!
Way to go, Madde! :) Nice to finally see you here!


text:
RICHARD COWPER - PROFUNDIS - GOLLANCZ, 1979, UK FIRST EDITION
London, Gollancz, 1979. Hardback first edition and first impression. A near fine copy.
J.G. Ballard - News from the Sun - Interzone, 1982, Signed Limited Edition.
Alastair Reynolds - Galactic North - Gollancz, 2006, First Edition.
Philip K. Dick - Eye in the Sky - Gregg Press, 1979, Later Edition.
A.E. van Vogt - The Universe Maker and The Proxy Intelligence - Sidgwick & Jackson, 1976, First Edition.
Greg Bear - Sleepside Story - Cheap Street, 1988, US Limited Edition
Alastair Reynolds - The Revelation Space Books [comprising] Revelation Space, Chasm City, Redemption Ark, Absolution Gap and The Prefect - Gollancz, 2000-2007, First Edition.
H.G. Wells - The Wheels of Chance - J.M. Dent, UK, 1896 - First Edition
Bob Shaw - 1 [One] Million Tomorrows - Gollancz, 1971, Signed First Edition.
Douglas Adams - Life the Universe and Everything - Arthur Barker, 1982, UK First Edition
J.G. Ballard - Concrete Island - Jonathan Cape, 1974, First Edition.
Edmond Hamilton - The Horror on the Asteroid - Gregg, US, 1975
John Wyndham - The Man From Beyond and Other Stories - Michael Joseph, 1975, First Edition.
John Taine - The Iron Star - E.P. Dutton, 1930, First Edition.
Paolo Bacigalupi - The Windup Girl - Night Shade Books, 2009, First Edition.
Jeff VanderMeer - Borne - Farrar Straus and Giroux, 2017, Signed First Edition.
Stephen Baxter - Flux - Harper Collins, 1993, Signed First Edition.
Paul McAuley - A Very British History - PS Publishing, 2012, UK Signed Limited Edition
A.E. van Vogt - The World of Null-A - Dobson, UK, 1969 - First Edition
C.M. Kornbluth - Best Science Fiction Stories of C.M. Kornbluth - Faber, 1958, First Edition.
Peter F. Hamilton - The Reality Dysfunction - Macmillan, UK, 1996 - Signed First Edition


This entry was posted in Authors, Editors, On Writing, Publishers, Writing rituals and tagged Charles Monteith, Editors, Maxwell Perkins, Nabokov, Notebooks, T.S. Elliot, Thomas Wolfe, Truman Capote, Writing process by Clodagh Phelan. Bookmark the permalink.


text:
Vol. 16, EPSC2022-1056, 2022, updated on 23 Sep 2022
https://doi.org/10.5194/epsc2022-1056
The Physical Properties of the Near Earth Asteroids 2005 UD and 2001 SG286
Radu Gherase1,2, Ovidiu Vaduvescu2,3,4, Thomas Wilson5, Marcel Popescu1, Julia de León4, Vania Lorenzi4, Javier Licandro4, David Morate4, Amadeo Aznar6, and Gabriel Simion1,7
Radu Gherase et al. Radu Gherase1,2, Ovidiu Vaduvescu2,3,4, Thomas Wilson5, Marcel Popescu1, Julia de León4, Vania Lorenzi4, Javier Licandro4, David Morate4, Amadeo Aznar6, and Gabriel Simion1,7
1Astronomical Institute of the Romanian Academy, 5 Cuțitul de Argint, 040557 Bucharest, Romania
2Faculty of Sciences, University of Craiova, Craiova, Romania
3Isaac Newton Group of Telescopes (ING), Apto. 321, E-38700 Santa Cruz de la Palma, Canary Islands, Spain
4Instituto de Astrofísica de Canarias (IAC), C. Vía Láctea, 1, 38205 San Cristóbal de La Laguna, Tenerife, Spain
5SUPA, School of Physics and Astronomy, University of St. Andrews, North Haugh, Fife KY16 9SS, UK
6Observatorio Isaac Aznar, Grupo de Observatorios APT C/La Plana, 44, 13, E-46530 Puçol, Valencia, Spain
7University of Amsterdam, Faculty of Science, 1090 GE Amsterdam, The Netherlands
Research into the orbital and physical properties near-Earth asteroids (NEAs) is important as these objects can reveal information about the origin and history of our planetary system.
Here we present our findings regarding the physical characteristics of the near Earth asteroids (NEAs) 2005 UD and 2001 SG286. The 2005 UD is currently a possible target for the DESTINY+ space mission, along with (3200) Phaeton which seems to share similar dynamic and physical characteristics. However, compared to Phaethon, there is still limited data available regarding 2005 UD. On the other hand, 2001 SG286 is another very interesting object, feasible as target for a sample-return mission which required additional observations to firmly establish its nature and composition.
In order to obtain the light-curves of these objects, we used the 2.5m Issac Newton Telescope (INT) equipped with Wide Field Camera CCD4 and the Sloan photometric filters. The visible spectrum of 2005 UD was captured using the INT with the Intermediate Dispersion Spectrograph (IDS) instrument. Furthermore, we used the 3.58m Telescopio Nazionale Galileo (TNG) equipped with the NICS instrument and the AMICI prism disperser to capture its infrared spectrum. The spectrum of 2001 SG286 was acquired using the 10.4m Gran Telescopio Canarias equipped with Optical System for Imaging and low Resolution Integrated Spectroscopy (OSIRIS) instrument. The observations of both objects were made during their recent favorable approaches (October 2018 for 2005 UD and October 2020 for 2001 SG 286).
For photometric data reduction we used the PHOTOMETRY PIPELINE by Michael Mommert and the MPO CANOPUS software with the reference stars from the GAIA and APASS catalogues, respectively. The nightly zero points were found to be consistent up to 0.1 magnitudes. MPO Canopus was finally used for the rotation period analysis, using the FALC (Fourier Analysis of Light Curves) algorithm. The light-curve plots are shown below. The "Reduced Magnitude" on the Y axis represents the Sloan filter magnitude values that have been corrected from sky magnitudes to unity distance by applying –5 * log(rR) to the initial measurements, where r is the Earth-asteroid distance and R is the Sun-asteroid distance. The X axis represents the rotational phase.
For 2005 UD, we found that a trimodal solution with a period of 7.85 hours is the best fit with polynomial orders ranging from 3 to 8, taking into account the INT data. This solution was previously suggested by Moskovitz in his presentation at PERC Int'l Symposium on Dust & Parent Bodies 2019 (IDP 2019) as a valid possibility, besides the predominant value of 5.23 hours currently found in the literature [1].
As for 2001 SG286, our analysis indicates that it is a non-principal axis slow rotator (tumbler), with overlapped rotational periods of 12.3 and 18.45 hours. Although we searched for a binary solution, we could not get a compelling result. Moreover, probabilistically there is a low chance of finding a companion given that the majority of binary asteroids are fast rotators.
2005 UD presents a C-type spectrum according to Bus-DeMeo classification.
In this case, we used the infrared data to calculate the thermal excess according to the thermal model described by Rivkin et al [2]. By further applying the aforementioned model and taking into account the heliocentric distance of the object at the time of the observation, we determined the geometrical albedo of 2005 UD to be pV = 0.06, which is in agreement to the latest estimate of Masiero et al [3].
On the other hand, the high quality spectral data obtained with GTC allowed us to firmly determine that 2001 SG286 is an S-type asteroid according to Bus-DeMeo classification, a result which is not in agreement with previous studies[4][5].
1. B. Warner and R. Stephens "Near-Earth Asteroid Lightcurve Analysis at the Center for Solar System Studies: 2019 July-September", Minor Planet Bull. 2020 Jan;47(1):23-34.
2. A.S. Rivkin et al. "Constraining near-Earth object albedos using near-infrared spectroscopy", Icarus 175 (2005) 175–180.
3. J. R. Masiero et al. "Asteroid Diameters and Albedos from NEOWISE Reactivation Mission Years 4 and 5", The Planetary Science Journal, 1:5, 2020 March
4. Binzel et al. "Dynamical and compositional assessment of near-Earth object mission targets", Meteoritics & Planetary Science 39, Nr 3, 351–366 (2004)
5. Popescu, M. et al. "Spectral properties of eight near-Earth asteroids", A&A 535, A15 (2011)
The work of RMG, and MP was supported by a grant of the Romanian National Authority for Scientific Research – UEFISCDI, project number PN-III-P1-1.1- TE-2019-1504. The work of MP, JdL, JL, is made in the framework of EU-funded project "NEOROCKS - The NEO Rapid Observation, Characterization and Key Simulations project", SU-SPACE-23-SEC-2019 from the Horizon 2020 - Work Programme 2018-2020, under grant agreement No 870403
How to cite: Gherase, R., Vaduvescu, O., Wilson, T., Popescu, M., de León, J., Lorenzi, V., Licandro, J., Morate, D., Aznar, A., and Simion, G.: The Physical Properties of the Near Earth Asteroids 2005 UD and 2001 SG286, Europlanet Science Congress 2022, Granada, Spain, 18–23 Sep 2022, EPSC2022-1056, https://doi.org/10.5194/epsc2022-1056, 2022.
EPSC2022-1056
We are sorry, but the discussion is only available for users who registered for the conference. Thank you.


text:
Sukma - District
Chhattisgarh Sukma
About Sukma District
Sukma is one of 27 districts located in Indian state Chhattisgarh. There are total 3 blocks which comes under Sukma district, and there are total 385 villages which comes under this district.
As per Indian government records district code of Sukma district is 805 and number of houses in this district is 49495.
Population of Sukma District
As per Census 2011, total population of this district is 221957. Out of total 221957, male population count is 108937, where as female population count is 113020 in Sukma.
Literacy of Sukma District
Literacy rate of Sukma district is 25%. 56242 out of total 221957 population is literate in this district.
Going in details, Male literacy rate in this district is 32% and 35815 males are literate out of total 108937 male population, where as female literacy rate is 81% and 20427 out of total 113020 females are literate in this district.
Coming to dark side, illiteracy rate of Sukma district is 74%. 165715 out of total 221957 population is illiterate in this village. In details, Male illiteracy rate in this district is 67% and 73122 males are illiterate out of total 108937 male population, where as female illiteracy rate is 81% and 92593 out of total 113020 females are illiterate in this district.
Agricultural status of Sukma District
Total working population of Sukma district is 131035 and non-working population is 90922 and out of 131035 working population 69156 peoples are totally dependent on agriculture.
Sukma's Members and followers list.
Be the first to like Sukma district.
Sukma District News
List of Blocks in Sukma District
Chhindgarh
Sukma


text:
La Plaça del Nord és una plaça del barri de Gràcia de Barcelona en un entrant del carrer de Verntallat i carrer de l'Alzina, i accessible pel carrer de Martí, a banda i banda. El seu nom s'ha mantingut al llarg dels anys, a excepció de la Segona República Espanyola quan s'anomenà Plaça de Joan Fuster, en honor del militant d'Estat Català mort en els primers dies de la Guerra Civil.

Descripció
És una plaça gairebé quadrada de 2.548 m² delimitada verticalment pel carrer de Verntallat i de l'Alzina, i talla pel mig el carrer de Martí. Compta amb 14 edificis numerats, dels quals destaquen l'escola La Salle Gràcia al número 14 i la seu dels Lluïsos de Gràcia en el 7. Aquest segon, és un edifici de dues plantes i la façana principal es divideix en tres blocs clarament diferenciats.

Història
La construcció de la plaça es feu com a part del procés d'urbanització de la zona l'any 1860 per encàrrec de Ramon Martí Balfus i Pau Vilaregut. Va ser encarregat a l'arquitecte Antoni Rovira i Trias igual que al pla de l'entorn de la plaça Rovira. Va anomenada del Nord per la seva situació geogràfica respecte al centre de la Vila i en contraposició de la Plaça d'Orient.

Un dels dos edificis emblemàtics de la plaça és la seu dels Lluïsos de Gràcia, una entitat sociocultural i esportiva que establí la seva seu a la plaça l'any 1897. L'altre edifici és el Col·legi La Salle Gràcia que es present des de 1967, després de passar prèviament pel carrer de l'Església des de 1892 i el carrer Sant Salvador 44 des de 1939.

Referències

Bibliografia

Nord
Nord


text:
Where Does Meerkat Go Without Twitter's Support?
With Twitter blocking Meerkat's access to it social graph, what happens next for the live-streaming app?
By Brandy Shaul
Live-streaming app Meerkat became the talk of the town at this year's SXSW in Austin, as attendees rushed to download the app and share their lives with others via real-time video streaming.
The app was such an instant success, Twitter decided to pull the plug on the access Meerkat (and other competing apps) had to Twitter's social graph, which decreases the app's ability to automatically notify users when their friends are streaming. Twitter recently purchased a competing live-streaming service, Periscope, so the move wasn't exactly a surprise.
While this hasn't killed Meerkat's momentum (as of this writing, the app is No. 192 on the top free iPhone apps chart, up from No. 1,168 on March 11, according to AppAnnie), it does leave Meerkat in a unique position. How does the app continue to grow without Twitter's support?
Jerry Jao, co-founder and CEO of Retention Science, a retention marketing platform helping brands re-engage their existing users and maximize customer lifetime value and engagement, gave us his thoughts:
Meerkat already caught the attention of early adopters. Even with the lockdown of the Twitter social graph, Meerkat must figure out other viral ways to increase user signup and sharing of the live streams. Meerkat already proved its value, and the rest is up to the founder's speed to execute features vs. what Twitter might add to its existing platform, to leverage the buzz Meerkat created for its social media platform.
In response to Twitter's decision to block Meerkat's access to the social graph, Meerkat CEO Ben Rubin told Yahoo Tech the company would build its own social graph features. "We are definitely going to start our own network," Rubin said in an interview. "We are already starting to decouple the social graph."
For now though, the app has received an update to help users connect, as users can search for others by their Twitter usernames and follow them to view their streams. Furthermore, a tutorial has been added to get new users up to speed, and sharing as quickly as possible.
Meerkat is available to download for free on the iTunes App Store.
http://adweek.it/1BDTyhj
TBWA's Walter Geer Wants to See More Focus on Older Ad Pros
The 25 Best Ads of 2019
DirectAvenue
Condé Nast, Custom Insights, Maternity Fill
Marketing and Communications Manager (Director of Marke...
Corporate Sales Manager