Aprilia Scooters Haynes Repair Manual covering the SR50, Rally, Sonic, Habana/Mojito from 1993 through 2009. Haynes writes every book based on a complete teardown of the motorcycle. We learn the best ways to do a job and that makes it quicker, easier and cheaper for you. Our books have clear instructions and hundreds of photographs that show each step. Step-by-step procedures, Easy-to-follow photos, Complete troubleshooting section , Valuable short cuts , Color spark plug diagnosis. Includes Routine Maintenance/Tune-up procedures. Engine clutch and transmission repair. Cooling system. Fuel and exhaust. Emissions control. Ignition and electrical systems. Brakes wheels and tires. Steering suspension and final drive. Frame and bodywork. Wiring diagrams.


Los Angeles' neighbor to the north might out-California-chill the City of Angels.
Los Angeles has just about everything you could want—delicious food, engaging cultural events, exquisite art, quirky locals, and the list goes on. So why go anywhere else? Well, for a certain kind of person looking for a certain kind of weekend away, Santa Barbara might actually be the better destination. Though skeptics are widespread, read this list for seven very good reasons to visit Santa Barbara over LA.
Whereas Los Angeles is a sprawling patchwork quilt of people and cultures and architectural styles, Santa Barbara has a cohesive look that will make even the least architecturally minded stop and stare. When it comes to admiring architecture, no trip to Santa Barbara is complete without a trip to the iconic Santa Barbara County Courthouse.
Yes, Los Angeles has a great night scene. Yes, there are awesome bars, clubs, and hotspots to check out in LA, but for the person who appreciates a fine wine, Santa Barbara is hands down the best place in Southern California. Love a rich, delicious red? Check. Prefer a tasty white? No problem, Santa Barbara wine country has you covered.
Santa Barbara wineries produce more than 50 varietals of grapes, meaning there is literally something for everyone. The perfect place to start a wine tasting journey in SB? Santa Barbara Urban Wine Trail, which is home to more than two dozen wineries.
Los Angeles has amazing food, but Santa Barbara's fare is truly next level. From to-die-for tacos to hyperlocal farm-to-table eateries, Santa Barbara has something for foodies of every sort. Pro tip: Don't skip a trip to McConnell's for a scoop (or two…or three) of ice cream. The lines regularly wind around the block, but it's worth the wait.
Lovers of the outdoors can find a lot to do in LA, but the hiking trails can be crowded and the beaches can be a nightmare. Not so in SB.
Tranquil and serene, wander through the gardens and grounds of @santabarbarabotanicgarden to discover 78 acres of rare and indigenous plants. #SeeSB 📷: @jonathan7r taken Jan. 11, 2018.
Love a classic, low-key romp through nature? The Santa Barbara Botanical Gardens are gorgeous. Want to see the beach as you walk? Try the Coastal Vista Trail. Looking for a like-grabbing Instagram post? Visit Inspiration Point.
Santa Barbara shines, together. We invite you to experience the resilience and passion of our community. #SeeSB 📷: @tomfiitz on Jan. 21, 2018.
There's no comparing the crowded, touristy beaches of Los Angeles with the serene coastal views in Santa Barbara. Leadbetter Beach is a classic destination and the Douglas Family Preserve is great for groups and family outings. The sunsets from every shore are absolutely jaw-dropping.
Dog lovers must visit Arroyo Burro Beach, which has a section for off-leash play with furry friends.
Anyone who loves the laidback, artistic vibes of Venice Beach or the hipster chic boutiques and cafés in Silverlake must visit the Funk Zone during a trip to Santa Barbara. The Funk Zone is one of the hippest, up-and-coming areas in Santa Barbara. It's a haven for artists and a great place for the young to get their wine tasting on.
Santa Barbara is close enough for a day trip, but even Angelenos should try to make time to stay overnight, if only to experience the city's amazing hotels. The Wayfarer in the Funk Zone mixes the communal vibe of hostels with the upscale chic feel of a boutique hotel.
For a more traditional boutique experience, book a stay at the Hotel Californian. The Spanish-inspired hotel spans three city blocks and the rooftop hotel is enough to make a vacation perfect all on its own.


text:
Q: Angular reactive form phone number pattern validation I have an add/edit reactive form with phone number input field. I have added a pipe that transforms the input from 9999999999 to (999) 999-9999 and I am using a regex pattern to validate the same.
HTML
<input [value]="form.get('phone').value | phoneFormat" maxlength="14" formControlName="phone"/>

phoneFormat is a pipe that converts the input value to desired format.

Component
this.form = this.formBuilder.group({
  phone: ['', [Validators.pattern(/((\(\d{3}\) ?)|(\d{3}-))?\d{3}-\d{4}/)]]
});

Issues

*

*I have to transform the phone value to 9999999999 while saving the form.

*While editing the form, the pattern validation fails initially because the phone number is not in desired format.

I am looking for a neat approach to handle this type of case.

A: This validation is possible without using any pipe for conversion or transforming its value. By using mask validation of RxWeb.
The @rxweb/reactive-form-validators has mask validation which can fulfill your validation requirement. It will validate your input as per the required regex format and save the value in its original form eg : 9999999999

export class UserComponent implements OnInit {
    userFormGroup: FormGroup

    constructor(
        private formBuilder: FormBuilder ) { }

    ngOnInit() {
        this.userFormGroup = this.formBuilder.group({
            phoneNumber:['', RxwebValidators.mask({mask:'(999)-999 9999' })],
        });
    }

    onSubmit(){
      console.log(this.userFormGroup.value);
    }
}

  <form  [formGroup]="userFormGroup">

      Phone Number
      <input type="text" formControlName="phoneNumber" class="form-control"  />
                          {{userFormGroup.controls.phoneNumber.errors.mask.message}}

    <button [disabled]="!userFormGroup.valid" class="btn btn-primary" (click)="onSubmit()">Submit</button>
  </form>

For implementing this you need to import RxReactiveFormsModule in the main module and use RxWebValidators while formControl initialization.
Here is the stackblitz link of the above example :  Open

A: why you change the form for saving?
just get the form value, assign it to an object and transform it as you want. but do not change the form value.
save() {
    let formValue = this.form.value;
    formValue.phoneNumber = formValue.phoneNumber.match(/(\d+)/);
    // rest of the job
}

and for the cases that you need to set form value (if it's a possible scenario) first normalize the phone number to the format that is valid then set the form value.
normalize(val) {
    let formValue = val;
    const phoneFormatPipe = new phoneFormat();
    formValue.phoneNumber = phoneFormatPipe.transform(formValue.phoneNumber);
    this.form.patchValue(formValue);
}

redpajama_set_name: RedPajamaStackExchange


probably. I believe it's just the same machine branded as a steam box with steam is installed.
Hmm... I dont have that Dell anymore. Cant remember what I did exactly. Maybe remove the card so it can only use iGPU? Or or make sure the primary display was set in the bios? It has an auto detect primary display feature. Maybe set it to be the iGPU or the Card. Try both.
A cheap USB sound card IIRC.
Hi - I'm trying on the same system - did you get the card going working?
And now it's back. Unsolved. Weird. :-) I thought after running the OSX update and a reboot that it had fixed itself. But seemingly not.
And if only Apple made a decent Mac mini at this price point with a decent GPU in it :/ If Dell can do it... how hard can it be Apple!
Very cool. Did you run a Geek Bench score? These are so cheap on eBay!
Hey, Do its not a laptop - no keyboard. It's basically like a Mac mini with a great GPU and upgradeable ram, cpu and ssd. Not sure what the ebay link is, I can find it. But basically any Alpha R1 will work. They are all the same where it counts, just different cpu.
My understanding is that the built in WiFi won't work. You need a USB WiFi adapter. I use eth at my desk so it didn't bother me. You can get cheap eth to WiFi bridges if you need one - that an option. Or Powerline ethernet, which is great.
Ok - Probably crashed the first time due to installing onto an external USB. Tried again on an internal I could reformat, and BINGO! Worked first time. No drama!. Amazing.


text:
Report: School shootings often involve guns from home
New report says school shootings often involve arguments that escalate, guns from home
Report: School shootings often involve guns from home New report says school shootings often involve arguments that escalate, guns from home Check out this story on USATODAY.com: http://usat.ly/1D6brw4
Larry Copeland, USA TODAY Published 8:07 p.m. ET Dec. 9, 2014 | Updated 12:21 a.m. ET Dec. 10, 2014
New report by gun violence prevention groups says school shootings often involve arguments that escalate and guns from home. There have been 95 school shootings since Newtown, Conn., groups say.
A police cruiser sits in the driveway and crime scene tape surrounds the home of Nancy Lanza in Newtown, Conn on Dec. 18, 2012.(Photo: Jason DeCrow, AP)
School shootings in the USA during the two years since the Newtown, Conn., massacre often involved a minor taking a gun from home and using it in a confrontation that started out as an argument, according to a new report by two groups who went to Washington, D.C., Tuesday seeking political action to prevent gun violence.
The two groups, whose definition of school shootings includes those those involving gang violence, unintentional shootings and suicides, used news accounts to compile a list of 95 shootings that occurred in 33 states; 23 of the incidents resulted in at least one death. All told, the shootings caused 45 deaths and 78 gunshot injuries, according to the report from Everytown for Gun Safety and Moms Demand Action for Gun Sense in America.
"Ninety-five school shootings is 95 too many," said U.S. Rep. Mike Thompson, a California Democrat who chairs the House's Gun Violence Prevention Task Force. "We must do more to keep the gunfire out of our children's classrooms, hallways and gymnasiums. That means keeping guns out of dangerous hands in the first place, and passing comprehensive background checks is the first step."
Forty-nine of the shootings occurred at K-12 schools and 46 on college or university campuses.
Of the 40 K-12 shootings in which the shooter's age was known, 28 were committed by minors. Of the 16 K-12 shootings where it was possible to determine the source of the firearm, 10 of the young perpetrators got their guns from home, the report says. In some cases, investigators in news accounts declined to say where the shooters obtained guns; other accounts did not provide the shooters' ages.
Shootings included incidents involving gang violence, unintentional shootings and suicides.
"School shootings ... erode the sense of security we should expect from our educational institutions in this country. Two years ago, the NRA called for arming teachers. That's their solution -- more guns for everyone, everywhere, anytime," said John Feinblatt, president of Everytown for Gun Safety. "Instead, we can and should do more to prevent gun violence. That's why we're fighting for common-sense public safety measures that respect the Second Amendment and keep guns out of the wrong hands."
The NRA did not respond to a request for comment.
Over the past two years, there were an average of two school shootings a month at K-12 schools, according to the report. During the past three months, there were 17 shootings, including one week -- Sept. 24-30 -- in which there were five incidents in five states: Texas, Tennessee, Indiana, North Carolina and Kentucky.
"We do not send our children to school to learn how to hide from gunmen, nor should we expect sharpshooting to be a job requirement for educators," said Shannon Watts, founder of Moms Demand Action. "You may not have heard about all of these shooting incidents on the national news, but when a lockdown is announced over a school intercom, for whatever reason, it strikes fear across the community. ... It's time for our elected leaders to take a stand for the safety and future of our children."
Everytown for Gun Safety, which calls itself the nation's largest gun violence prevention organization, was born this year out of the merger between Mayors Against Illegal Guns, founded in 2006 by then-mayor Michael Bloomberg of New York and 14 other mayors, and Moms Demand Action for Gun Sense in America, which was begun by Watts, an Indianapolis stay-at-home mom, in response to the Sandy Hook school shooting.
On Dec. 14, 2012, Adam Lanza, 20, shot and killed his mother, then drove to Sandy Hook Elementary School and launched the nation's deadliest mass shooting at a high school or grade school. He then shot and killed himself.
Read or Share this story: http://usat.ly/1D6brw4

redpajama_set_name: RedPajamaCommonCrawl


These mod earrings have a prominent gold hoop dangling from a flat disk stud. The hoop is hollow making these lightweight and easy to wear. Posts with ear nut backings.
CONDITION / Some minor tarnish on stud but otherwise great vintage condition.


We have been established since 1971 as a family owned and operated business.
We have grown into a reputable Kitchen & Cabinetmaking Joinery offering Personal and reliable service. Our customers deal directly with us, which guarantees you will get the care and commitment to your project every time.
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text:
Le Grand Prix automobile de France 1935 est un Grand Prix hors-championnat qui s'est tenu sur l'autodrome de Linas-Montlhéry le .

Grille de départ

Classement de la course

 Légende: Abd.=Abandon - Np.=Non partant.

Pole position et record du tour
 Pole position :  Achille Varzi (Auto Union) en 5 min 20 s 1.
 Meilleur tour en course :  Tazio Nuvolari (Alfa Romeo) en 5 min 29 s 1.

Tours en tête

Références

Sport automobile en France
Sport automobile en 1935
Sport en France en 1935

redpajama_set_name: RedPajamaWikipedia


text:
Édouard Therriault skis to bronze medal in Font-Romeu
Édouard Therriault had a specific plan in mind and followed it to the letter on Sunday in the slopestyle final in Font-Romeu, France. The result? A bronze medal – and his first-ever World Cup podium finish.
"I had my routine set, and I went into it without thinking or worrying too much about what everybody else was going to do. I just believed in myself, trusted myself and it worked out great. I'm really happy with my performance. It's an amazing feeling," said Therriault, post-medal ceremony.
The native from Lorraine, Québec, showed competitors and spectators alike what he can do on the slopes this Sunday. He demonstrated a varied style and a lot of range and earned himself provisional second place in the first round with 81.71 points. On the second run, he tried to raise the bar yet again but was unable to improve his score.
Only two competitors surpassed the Canadian skier's performance on Font-Romeu's slopes. Switzerland's Andri Ragettli – reigning world champion in the discipline – was the eventual winner with a score of 86.36, while New Zealand's Ben Barclay (82.71 points) earned the silver.
Also competing in France were Teal Harle (Campbell River, BC) and Mark Hendrickson(Calgary, AB), who were themselves in hot pursuit of the podium. In the end, both Canucks had to settle for very respectable finishes just off the podium – Harle (81.46 points) finished fourth, just ahead of Hendrickson in fifth with 80.63 points.
Etienne Geoffroy-Gagnon (Whitehorse, YT) qualified for the final but was unable to start. He finished the day in 15th place overall.
"We all really wanted to do well leading to the Olympics and to secure more spots for Canada in future competitions. I'm really proud of my team and what we did this weekend – I feel like we outdid ourselves and it's really fun for Canada. We pulled together," continued bronze medalist Therriault.
Skier Édouard Therriault's list of achievements was already impressive prior to this first-ever World Cup podium. In Kläppen, Sweden in 2019, the now 18-year old was crowned World Junior Slopestyle Champion, and in March 2021 at Senior Worlds in Aspen, he took many by surprise by winning a silver medal in the Big Air event.
This week he's heading back to that same venue in Aspen to compete in his first X Games, where he'll want to take advantage of every experience and, of course, continue making progress towards possible participation in the Beijing 2022 Olympic Winter Games.
"The X Games have been my dream since I was young, so next weekend is going to be an incredible experience! The more the season progresses, the better I feel on my skis, and the better my results are. I really believe I have good momentum right now. As always, my goal is to improve on my own performances, and that's what I'm going to aim for again," he concluded.
Previous: Mikaël Kingsbury nabs seventh podium ahead of the Beijing 2022 Olympic Winter Games
Next: 24 freestyle skiers nominated to represent Team Canada at Beijing 2022


With over 30 million visitors a year, Las Vegas is the entertainment capital of the world. From the gorgeous mega-luxury hotels to the exclusive Vegas shows to the unbeatable buffets to the 24 hour casinos, Las Vegas has something for everyone. More and more travellers are booking their Las Vegas trips online. So should you book your next Las Vegas vacation online? Here are the top 5 reasons to consider booking your Vegas vacation online: 1) Save Money You don't have to pay travel agent commissions which can amount to significant savings of hundred of dollars.
Plus there are direct-to-customer online travel services that give you special discounts just for booking online. 2) Convenience Book your Vegas vacation from the comfort of your own home. You don't have to go out to pick up the tickets or haggle with travel agencies.
You simply shop, click, book and print - easy as that. (and if you have questions, there's usually a toll free number you can call for 24 hour support) 3) Larger Selection of Las Vegas Packages: Instead of just choosing from the latest travel agent specials you can choose from EVERYTHING that's available. You know what you want in a Las Vegas vacation better than anyone else - and you can easily browse everything that's available to you online. Many online travel agents upload new vacation packages weekly so you can monitor the new packages being offered and find an amazing deal. 4) Easy To Search & Book With easy search functions and large travel package databases, you simply plug in your search parameters and get a listing of possible trips, prices and descriptions.
The easy search functions make it simple and fun to find the Las Vegas vacation of your dreams 5) Research Hotels and Find Out What Other Travellers Think - BEFORE You Get There Ever travelled some place, got there and thought - 'I wish someone had told me what this place was really like before I spent all this money!'? Now you can know what your Vegas hotel is like before you stay there. Many online travel agents have pictures, detailed descriptions and even downloadable brochures on each Las Vegas resort. And some online travel agents are also introducing a Travellers' Opinions section where people can leave feedback and rate their hotel vacation experience. They rate hotels and also leave comments on their experience. This is a great tool for you to not only find out which hotels are popular with other travellers but you can usually also pick up other Vegas travel tips that can save you money. Considering all this, it's no wonder that more and more people are booking their Las Vegas trip online, it's easier, cheaper and you end up making a better choice (and thus having a more enjoyable vacation).
For a list of the most popular online travel agents with a large selection of Vegas vacation packages visit: http://www.BookVegasOnline.com/Where_To_Book_Vacation_Onl ine.html .


A gamecock, found at a "backwoods" auction, sits proudly among the greenery on the fireplace mantle in the game room.
The music room with its grand piano, shimmers with gold holiday décor and candlelight. The light fixture on the mantle was originally thought to be just a figurine when Andrew spotted it at a Chicago auction.
Furniture in the music room includes pieces that represent the period when the house was completed in 1885, including Eastlake styles featuring rich, red velvet upholstery. Paintings in the impressionist style by local artist Weston Courier flank the large entryway to the dining room.
Holiday decorations throughout the house, including those on the front porch provide a festive atmosphere.
Across the wide hallway from the music room is the library with its own elaborate fireplace accented with J.J. & G. Low Art Tiles.
Holiday décor beautifully highlights the detailed craftsmanship of the library's fireplace mantel.
The dining room glows under the soft light of the room's crystal chandelier and wall sconces. The Venetian glass mirror as well as glass tabletops set with china and silver featuring different patterns makes for a sophisticated dining experience.
The music room's fireplace mantel extends to the ceiling and includes a lion carved into the arched woodwork across the top.
The game room is a fun place for guests to congregate. Just some of its highlights include a roulette wheel and the home's original pump organ, as well as framed architectural drawings.
The home's main staircase to the second floor is made of four different woods, including cherry, and is wrapped with garland, ribbon and tiny lights during the holidays. A large, 4 ft. wide by 6 ft. high pastel watercolor painting purchased at an estate sale also hangs in the stairwell and serves as a perfect backdrop for wedding photos.
Baker House, the architectural gem with its ornate details fully preserved and recognized by the National Register of Historic Places, is even more stunning during the holidays. When this luxury hotel is dressed in its yuletide finery and its fireplaces are burning brightly, this giant of a building with its grand scale and elegant appointments welcomes you like a long-lost friend. One could speculate that the property's refined style mixed with its comfortable ease would be fondly embraced by Emily Baker, who built this Queen Anne beauty over 130 years ago as a tribute to her late husband, Robert Hall Baker.
Originally known as Redwood Cottage for its seven patterns of exterior shingles made from the giant California redwoods, the 30 room, 17,000-square-foot home was the work of only the finest craftsmen, and it equaled the design and attention to detail of any home on Geneva Lake. Its 13 fireplaces built with hand-carved mantels are accented with highly collectible, J. J. & G. Low Art Tile manufactured in Chelsea, Massachusetts. In addition, the home boasts beautiful inlaid wood floors, intricate wood moldings and trim, stained glass windows and ceiling heights ranging from 10-14 feet, giving the salons, parlors and guestrooms massive volume.
Although the property has been reinvented several times since the Baker family's use as a summer cottage — a sanitarium for the wealthy, a boarding school for girls, a hotel in the 40s and 50s, upscale restaurants, first the St. Moritz, then Gilbert's — it wasn't until 2010 when Andrew Fritz purchased the house that it was truly brought back to its former glory. Then he and his expert team painstakingly scoured antique auctions, estate sales and consignment shops to fill this grand dame with period furnishings and unique finds.
The bygone era of vintage glamour combined with fun and frivolity thrives at Baker House today through regular live music, high teas, murder mystery events and their fabulous Sunday brunch. The property's slogan, "Come See How Something So Old Can Be, OH! So New," has never been truer.


Maria Garcia-Alonso is a Senior Lecturer in Economics. She was born in 1970 in Vigo (north west of Spain). After graduating in Economics at the University of Vigo, she moved to the University of Autonoma de Barcelona where she was awarded her PhD in 1998. She joined the University of Kent as a Lecturer in 1999.
Maria's research applies the methodology found in Industrial Economics and Game Theory to the analysis of economic problems that capture her interest. Her topics of research include the study of the regulation of the arms trade, dual use goods export controls, conflict analysis, health markets and access to medical innovations in lower income countries. At present, Maria is working on the analysis of terrorism and also the strategic interaction of parental decisions as inputs in human capital development. Maria has published her research in journals such as International Journal of Industrial Organisation, Journal of Health Economics and Oxford Economic Papers.
Maria is the School's Director of Education and a member of the Strategic Management Team.
Maria's publications can also be found on RePEc, Orcid and ResearchGate.
Garcia-Alonso, M., Levine, P. and Smith, R. (2016). Military aid, direct intervention and counterterrorism. European Journal of Political Economy [Online]. Available at: http://dx.doi.org/10.1016/j.ejpoleco.2016.06.006.
We analyze the choice often faced by countries of whether to directly intervene to counter an external terrorist threat or to subsidize a foreign government to do it. We present a model which analyzes this policy choice where two countries, home and foreign, face a terrorist threat based in the foreign country. The home country chooses how much to invest in defending itself and in reducing terrorist resources either indirectly by subsidising the foreign country or by directly by intervening itself and risking destabilizing the foreign country. Using a calibrated model, we are able to show that direct intervention is only an equilibrium if foreign and home efforts are not good substitutes in the technology used to reduce the resources of the terrorist group. A higher relative military efficiency by the home country makes intervention more likely.
Acharyya, R. and Garcia-Alonso, M. (2014). Universal access, parallel trade and incentives to innovate. Bulletin of Economic Research 66:S74-S91.
Governments often subsidize poorer groups in society to ensure their access to new drugs. We analyze the optimal income-based price subsidies in a strategic environment. We show that universal access is less likely to arise when price arbitrage prevents international price discrimination. When this is not the case, under some income ranges, bilateral universal coverage can be supported by equilibrium subsidies together with bilateral partial provision. In such a case, international health policy coordination becomes relevant. We also show that asymmetric universal access to medicines across countries can arise, even when countries are ex-ante symmetric, when international price discrimination is possible and governments cannot design subsidies proportional to either income or quality.
Acharyya, R. and Garcia-Alonso, M. (2012). Income based price subsidies and parallel imports. International Review of Economics and Finance [Online] 22:25-41. Available at: http://dx.doi.org/10.1016/j.iref.2011.08.001.
We present a policy game where a Rich country has a higher ability than a Poor country to commit to certain elements of health policy such as providing income related price subsidies and allowing parallel imports (PI). When allowing PI is not a choice for the Poor country, the Rich country allows PI and both countries provide a subsidy to their poorer buyers as the subgame perfect equilibrium policies. However, when the Poor is able to PI a different equilibrium may arise. We show that the ability of the Poor to allow PI might increase welfare in this country even if it is never implemented. We also prove that as the Poor country gets richer, it will not be in their best interest to sign an agreement with the Rich to commit to not allowing PI.
Garcia-Alonso, M. and Acharyya, R. (2011). Parallel imports, drug innovation and international patent protection: a policy game. Journal of International Trade and Economic Development [Online] 21:865-894. Available at: http://dx.doi.org/10.1080/09638199.2010.541273.
We consider a policy game between a high-income country hosting a drug innovator and a low-income country hosting a drug imitator. The low-income country chooses whether to enforce an International Patent Regime (strict IPR) or not (weak IPR), and the high-income country chooses whether to allow parallel imports (PI) of on-patent drugs or market-based discrimination (MBD). We show that, for a moderately high imitation cost, both (strict IPR, PI) and (weak IPR, MBD) emerge as the subgame prfect Nash equilibrium (SPNE) policy choices. For relatively smaller imitation costs, (weak IPR, MBD) is the unique SPNE policy choice. The welfare properties reveal that although innovation may be higher at the (strict IPR, PI) policy regime, the market coverage and national welfare of the low-income country, and the total welfare are all lower. This opens up the efficiency issue of implementing TRIPS and at the same time allowing international exhaustion of patent rights.
Acharyya, R. and Garcia-Alonso, M. (2008). Parallel imports, innovations and national welfare: The role of the sizes of the income classes and national markets for health care. Singapore Economic Review 53 No.:57-79.
Garcia-Alonso, M. and Garcia-Marinoso, B. (2008). The strategic interaction between firms and formulary committees: effects on the prices of new drugs. Journal of Health Economics [Online] 27 Iss:377-404. Available at: http://dx.doi.org/10.1016/j.jhealeco.2007.06.003.
We study the strategic interaction between the pricing decisions of a pharmaceutical firm and the reimbursement decisions of a government agency which grants reimbursement rights to patients for whom new drugs are most cost-effective. If the reimbursement decision precedes pricing, the agency only reimburses some patients if the drug's private and public health benefits diverge. This is, there are consumption externalities and the variable cost of the drug exceeds the alternative's. Contrarily, if the firm can commit to a price before reimbursement, a strategic effect implies that by setting a sufficiently high price, the firm can make the agency more willing to reimburse than without commitment.
Garcia-Alonso, M. and Levine, P. (2008). Strategic procurement, openness and market structure. International Journal of Industrial Organization [Online] 26:1180-1190. Available at: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6V8P-4RDS1H5-1&_user=125871&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000010239&_version=1&_urlVersion=0&_userid=125871&md5=2fc6d72450aa7c6ef9f47f55b207fa99.
We examine strategic procurement behaviour by governments and its effect on market structure in sectors, such as defence and pharmaceuticals, where the government is the dominant consumer. In a world economy with trade between producer countries, and between producers and non-producers, we use a modified Dixit–Stiglitz utility function with an independent taste for variety. There is free entry and exit by firms, but by anticipating their participation constraint governments can indirectly choose the number of domestic firms and their size through its choice of procurement price. Unlike the standard model with no independent taste for variety and no external sector of non-producer countries, there are incentives for subsidies, openness impacts on industrial structure and procurement coordination between producer countries affects firm numbers.
Garcia-Alonso, M. et al. (2007). Determining the defence industrial base. Defence and Peace Economics [Online] 18:199-221. Available at: http://dx.doi.org/10.1080/10242690600924273.
This paper models the determination of the defence industrial base - the number of different military systems a country decides to maintain. High R&D costs means that few countries can afford to produce major weapons systems and the producers also import systems. Non-producers rely on imports and we assume their demand is driven by regional arms races. Military capability is determined by the number of systems and the quantity and quality of each. We examine how the defence industrial base is influenced by military expenditures, R&D costs, export controls, the nature of regional arms races and a variety of other factors.
Dunne, J. et al. (2006). Managing asymmetric conflict. Oxford Economic Papers 58:183-208.
This paper considers a simple model of asymmetric conflict, between an incumbent, e.g. government or dominant firm, and potential challengers, e.g. guerrillas or entrants. It is not uncommon for challengers to win such conflicts despite their lack of resources. One way they can do this by exploiting a second mover advantage: choosing to attack the incumbent in ways that it had not prepared for, because it was locked in by past investments. To model such asymmetric conflict we use a three stage game. In the first stage the incumbent chooses effort; in the second stage the challengers choose the degree of differentiation from the incumbent and in the third stage each decide whether to attack or defend and collect their payoffs. Although the game is simple, the calculations required from the players are difficult and shed light on the complexities of many conflicts.
Garcia-Alonso, M. and Acharyya, R. (2006). Self-interested international income redistribution and access to health care innovation. European Journal of Political Economy [Online] 22:322-336. Available at: http://dx.doi.org/10.1016/j.ejpoleco.2005.08.002.
We study how income redistribution affects decisions of a health care innovator and the utility of individuals. We find that income redistribution from rich to poor can increase the quality of medical innovation and the utility of some consumers whose income is reduced through the redistribution. We therefore find a non-altruistic motive for international income transfers that would increase access to health innovations.
Garcia-Alonso, M. and Levine, P. (2005). Arms export controls, subsidies and the WTO exemption. Scottish Journal of Political Economy [Online] 52:305-322. Available at: http://www3.interscience.wiley.com/journal/118689970/abstract?CRETRY=1&SRETRY=0.
Owing to the World Trade Organization (WTO) exemption that allows governments to subsidize arms exports, the arms trade is one of the few remaining areas of trade where we observe export subsidies. This paper examines the effect of arms controls, in the form of licensing delays, on the incentives to subsidize arms exports and conversely the effect of the WTO arms trade exemption on the incentives to break arms control agreements. Our main result is that arms controls and free trade commitments re-enforce each other. Licensing delays reduce the incentive to subsidise and free trade without subsidies reduces the benefits of a unilateral abrogation of arms controls. Transparency actually worsens the Nash inefficiencies at play in that incomplete information leads to lower subsidies and lower arms exports.
Garcia-Alonso, M. and Levine, P. (2007). Arms trade and arms races: a strategic analysis. in: Sandler, T. and Hartley, K. eds. Handbook of Defense Economics: Defense in a Globalized World: v. 2: Defense in a Globalized World. Netherlands: North-Holland Publishing Co., pp. 941-969.
Garcia-Alonso, M. and Smith, R. (2006). The economics of arms export controls. in: Joyner, D. ed. Non-Proliferation Export Controls: Origins, Challenges, and Proposals for Strengthenin. Ashgate Publishing Group, pp. 29-48.
Maria's research in the past few years has been in the fields of Industrial Organization and International Trade. The objective has been to understand the strategic interactions between governments which are involved in arms production and arms control. More generally, Maria has also been interested in the impact of public procurement policies on market structure with an application to both defense and pharmaceutical industries.
At present, she is developing models that try to explain the characteristics of the national and international regulation in health markets.


text:
using System;
using System.Linq;
using System.Windows.Controls;

namespace NAudioWpfDemo.MediaFoundationResample
{
    /// <summary>
    /// Interaction logic for MediaFoundationResampleView.xaml
    /// </summary>
    public partial class MediaFoundationResampleView : UserControl
    {
        public MediaFoundationResampleView()
        {
            InitializeComponent();
        }
    }
}

redpajama_set_name: RedPajamaGithub


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text:
Yilmaz Atadeniz
Who is Yilmaz Atadeniz? He is a male celebrity. He was born on Monday February 1st 1932, in Istanbul, Turkey,.
Yilmaz Atadeniz is the philanthropist and humanitarian who is deeply concerned about the state of the world, for which he has great compassion and idealism. He has a utopian personality, and will spend her life trying to realize some aspect of her utopian dream, sacrificing money, time, and energy for a better world.
His broad outlook on life allows Atadeniz to see the big picture, and to often shy away from dealing with the minute details. That is why Yilmaz Atadeniz attracts people who can fit into her larger plans and take over the areas he considers uninteresting. Consequently, Yilmaz evaluates people on the basis of what they can do for the larger cause. He is a true egalitarian, rarely prejudiced and would not accept social biases of people.
Interior decorating, landscape art or photography can be the sort of fields in which Yilmaz's imagination and creativity can harmoniously arrange the beauty already potential in the environment. However, due to his strong social consciousness - he can be an effective politician, lawyer, judge, minister, teacher, healer, environmentalist or in any other vocation that carries a clear social impact.
Yilmaz Atadeniz has a romantic personality, but his love is more impersonal as he tends to be focused on her dreams instead. When not in harmony with his true nature, Yilmaz can fall to moodiness, or become aloof, and withdrawn. He can also become timid, uncertain, and ungrateful, putting the blame for his troubles on others or the world. He is often disappointed by the realities of life, her own shortcomings, and those of others, and is relentlessly driven to improve upon it all - striving for greater accomplishments. This is Yilmaz's life-lesson - to accept the natural limitations of the world and its habitants in order to make it possible for him to enjoy life more fully.
Atadeniz must learn to let go of material possessions and relationships because holding on too tightly to anything causes him pain. The more he gives, the bigger is his reward, and the most successful and satisfying road for him is sharing and sacrificing for the larger goal, without expecting anything in return. Yilmaz Atadeniz's greatest chance at success is to tie his personal fortunes to an endeavor that makes the world a better place for others. It may very well turn into a highly successful and lucrative enterprise, providing amply for Yilmaz and her family. More...
More flavors to Yilmaz's personality
Yilmaz Atadeniz is a person of thinking and planning.
It is natural for Yilmaz to think before he acts, to constantly plan the short- and long-term future, and to keep elaborate notes and diary with everything well planned and written down.
If Yilmaz is over-organized, he should practice finding his way in disarrayed environment, or otherwise feel confused and in disarray himself.
But if he ignores the details in favor of the bigger picture, others might view Atadeniz as undisciplined with details, and not appreciate his great planning skills.
Tour Yilmaz's menu and gain more insight into his personality traits, relationships, strengths and weaknesses, likes and dislikes, compatibility with you and with others, and much more.
January 17th 2022 brings Yilmaz Atadeniz a sense of completion and feelings of accomplishment.
The day presents Yilmaz with an opportunity for healing mind and body. He should treat himself and get plenty of rest.
Today also carries an emotional overtone that is expressed by strong feelings and even some melodrama.
While the day starts with lack of concentration, it turns out later to be a good day for conversation and strengthening of ties.
You and Yilmaz
Other male celebrities born on the same day as Yilmaz Atadeniz
Harry Styles (1994)
An English singer and songwriter who auditioned as a solo artist for the British television series The X Factor, and was met there with four other contestants, to form the group that would later become known as One Direction
Langston Hughes (1902-1967)
An American poet, social activist, novelist, playwright, and columnist, who was one of the earliest innovators of the then-new literary art form called jazz poetry, and is best known as a leader of the Harlem Renaissance in New York City
Frederick Douglass (1818-1895)
An African-American orator, writer, social reformer, abolitionist and statesman who escaped from slavery, becoming national leader of the abolitionist movement who produced incisive antislavery writings and dazzling oratory speaches
Michael C. Hall (1971)
An American actor who graduated from New York University's graduate acting program at the Tisch School of the Arts, and is best known for his roles as Dexter Morgan, a serial killer and blood spatter analyst in the Showtime series Dexter, for which he won a Golden Globe Award and a Screen Actors Guild Award, and as David Fisher in the HBO drama series Six Feet Under
Rick James (1948-2004)
An American musician and composer
Brandon Lee (1965-1993)
An American actor and martial artist who started his career playing in the 1986 television film Kung Fu: The Movie, and became a leading man in low-budget action films made outside of the US during the mid to late 1980s such as Legacy of Rage and Laser Mission
Clark Gable (1901-1960)
An American film actor, often referred to as "The King of Hollywood"
Pauly Shore (1968)
An American actor, active stand-up comedian, director, writer and producer who starred in several comedy films in the 1990s and hosted a video show on MTV in the late 1980s and early 1990s
Lee Thompson Young (1984)
Kevin Martin (1983)
An American retired professional basketball player, who at 6'7'' was ranked second in the nation while playing college basketball for Western Carolina University, and played 12 seasons in the National Basketball Association (NBA).
Yilmaz Atadeniz personality profile | © Copyright 2009-2022 Celebrities Galore and Master Numerologist Hans Decoz


1) If you stay ready you never have to get ready. 2) Pruney zombies are the worst. 3) Humans are the real monsters. – This week is bug-out bags, unmarked bills, puddles of bodies, refueling logistics, the inevitable bike surplus, school buses, Snowpiercer, family guy, and Mad Max Train Trax. I and U. Trains on the water. Boats of the tracks.
Topic – If you could have any non-military vehicle during a zombie apocalypse what would it be and why?


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text:
Yang, X, Wipperman, M. F., Nachman S., Sampson, N. S. (2022) "Exploring the value of Mycobacterium tuberculosis modified lipoprotein as a potential biomarker for TB detection in children," BMC Infectious Diseases, 22, article # 158. DOI: 10.1186/s12879-022-07140-9, https://rdcu.be/cHfoR PMC8851740
Boadi, F. O., Sampson, N. S. (2021) "Gradient copolymer prepared from alternating ring-opening metathesis of three monomers" 12, 5613 – 5622, Polymer Chemistry DOI:10.1039/D1PY00690H
Youn, G., Sampson, N. S. (2021) "Substituent effects provide access to tetrasubstituted ring-opening olefin metathesis of bicyclo[4.2.0]oct-6-enes," 1, 29-36, ACS Organic and Inorganic Au. DOI: 10.1021/acsorginorgau.1c00016.
Rosa, T.L.S.A., Marques, M.A.M., DeBoard, Z., Hutchins, K.M., Silva, C.A.M., Montague, C.R., Yuan, T., Amaral, J.J., Atella, G. C., Rosa, P. S., Mattos, K. A., VanderVen, B. C., Lahiri, R., Sampson, N. S., Brennan, P., Belisle, J. T., Pessolani M. C. V., and Berredo-Pinho, M* (2021) "Reductive power generated by Mycobacterium leprae through cholesterol oxidation contributes to lipid and ATP synthesis," Front. Cell. Infect. Microbiol. – Bacteria and Host. 11, 701, DOI: 10.3389/fcimb.2021.709972.
Yuan , Τ., Werman, J. M., Yin, X., Yang, M., Garcia-Diaz, M., Sampson, N. S. (2021) "Enzymatic β-oxidation of the cholesterol side chain in Mycobacterium tuberculosis bifurcates stereospecifically at hydration of 3-oxo-cholest-4,22-dien-24-oyl-CoA," ACS Infectious Diseases. 7, 1739-1751. DOI: 10.1021/acsinfecdis.1c00069.
Youn, G., Cervin, J., Yu, X., Bhatia,S. R., Yrlid, U. and Sampson, N. S., (2020) "Targeting multiple binding sites on cholera toxin B with glycomimetic polymers promotes formation of protein–polymer aggregates," Biomacromolecules 21, 4878-4887. DOI: 10.1021/acs.biomac.0c01122
Zhang, J., Yu, X., Zheng, B., Shen, J., Bhatia, S. R., and Sampson, N. S. (2020) "Cationic amphiphilic alternating copolymers with tunable morphology," Polymer Chemistry 11, 5424-5430. DOI: 10.1039/D0PY00782J
Cervin, J., Boucher, A., Youn, G., Björklund, P., Wallenius, V., Mottram, L., Sampson, N. S., and Yrlid, U. (2020) "Fucose-galactose polymers inhibit cholera toxin binding to fucosylated structures and galactose-dependent intoxication of human enteroids, ACS Infectious Diseases 6, 1192-1203, DOI: 10.1021/acsinfecdis.0c00009
Bonds, A, Yuan, T. Werman, J. M., Jung, J, Lu, R., Nesbitt, N. M., Werman, J., Garcia-Diaz, M., and Sampson, N. S. (2020) "Post-translational succinylation of Mycobacterium tuberculosis enoyl-CoA hydratase EchA19 slows catalytic hydration of cholesterol catabolite 3-oxo-chol-4,22-diene-24-oyl-CoA," ACS Infectious Diseases. 6, 2214-2224, DOI: 10.1021/acsinfecdis.0c00329
Boadi, F. O., Zhang, J., Yu,X., Bhatia,S. R., and Sampson, N. S. (2020) "Alternating ring-opening metathesis polymerization provides easy access to functional and fully degradable polymers," Macromolecules. 53, 5857-5868, DOI: 10.1021/acs.macromol.0c01051
Gadbery, J. E., Round, J. W., Wipperman, M. F., Yuan, T., Story, K. T., Crowe, A. M., Casabon, I., Liu, J., Yang, X., Eltis, L. D., and Sampson, N. S. (2020) "IpdE1-IpdE2 is a heterotetrameric acyl coenzyme A dehydrogenase that is widely distributed in steroid-degrading bacteria", Biochemistry. 59, 1113-1123 DOI: 10.1021/acs.biochem.0c00005
Yuan, T., Yang, M., Gehring, K., and Sampson, N. S. (2019) "Mycobacterium tuberculosis exploits a heterohexameric enoyl-CoA hydratase retro-aldolase complex for cholesterol catabolism," Biochemistry. DOI: 10.1021/acs.biochem.9b00673
Gadbery, J. and Sampson, N. S. (2019) "Applications of ICMT for protein structure determination," Meth. Enzymol. 621, 245-260. DOI: 10.1016/bs.mie.2019.02.02
Yang, X, Yuan, T., Ma, R., Chacko, K. I., Smith,M., Deikus,G. Sebra, R., Kasarskis, A., van Bakel, H., Franzblau, S., and Sampson, N. S. (2019) "The Mce3R stress-resistance pathway is vulnerable to small-molecule targeting that improves tuberculosis drug activities," in press ACS Infect. Dis. 10.1021/acsinfecdis.9b00099
Gadbery, J, and Sampson, N. S. (2018) "Use of an Isotope-Coded Mass Tag (ICMT) Method to Determine the Orientation of Cholesterol Oxidase on Model Membranes," 57, 5370-5378, Biochemistry.DOI: 10.1021/acs.biochem.8b00788 PMC6171977
Zhang, J., Li, G., and Sampson, N. S. (2018) "Incorporation of large cycloalkene rings into alternating copolymers allows control of glass transition and hydrophobicity," 7,1068–1072,ACS Macro. Lett. DOI: 10.1021/acsmacrolett.8b00510 PMC6156091
Li, G. and Sampson, N. S. (2018) "Alternating Ring-Opening Metathesis Polymerization (AROMP) of Hydrophobic and Hydrophilic Monomers Provides Oligomers with Side-Chain Sequence Control," 51, 3932–3940, Macromolecules. DOI: 10.1021/acs.macromol.8b00562. PMC6262599
Bonds, A. and Sampson, N. S. (2018) "More than catabolism: Regulatory vulnerabilities in Mycobacterium tuberculosis,"Curr. Opin. Chem. Biol. 44, 39-46. DOI: 10.1016/j.cbpa.2018.05.012
Wands, A.M., Cervin, J., Huang, H., Zhang, Y., Youn, G., Brautigam, C. A., Dzebo, M. M., Bjorklund, P. Wallenius, V., Bright, D.K., Bennett, C.S., Wittung-Stafshede, P., Sampson, N.S., Yrlid, U., and Kohler, J.J. (2018) "Fucosylated molecules competitively interfere with cholera toxin binding to and intoxication of host cells," 4, 758-770, PMC5948155, ACS Infect. Disease. DOI: 10.1021/acsinfecdis.7b00085
Chen, L., Liu, L., and Sampson, N. S. (2018) "Access to bicyclo[4.2.0]octene monomers to explore the scope of alternating ring-opening metathesis polymerization," 83 2892–289. J. Org. Chem. DOI: 10.1021/acs.joc.8b00054.
monomers may be purchased through Kerafast:
https://www.kerafast.com/product/3468/bicyclo420oct-8-ene-8-carboxylic-acid
https://www.kerafast.com/product/3469/bicyclo420oct-8-ene-8-carbonitrile Yuan, T. and Sampson, N. S. (2018) "Hit generation in TB drug discovery: from genome to granuloma," Chem. Reviews,
,1887-1916. DOI: 10.1021/ acs.chemrev.7b00602
Alford, V. M., Kamath, A., Ren, X. Kumar, K., Gan, Q., Awwa, M., Tong, M., Seeliger, M., Cao, J., Ojima, I., and Sampson, N.S. (2017) "Targeting the hemopexin-like domain of latent matrix metalloproteinase-9 (proMMP-9) with a small molecule inhibitor prevents the formation of focal adhesion junctions," 12, 2788-2803, ACS Chemical Biology DOI: 10.1021/acschembio.7b00758
Rui Lu, Christin M. Schaefer, Natasha M. Nesbitt, Jochen Kuper, Caroline Kisker, and Nicole S. Sampson
"Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis is Controlled by a Redox-Sensitive Thiol Switch," ACS Infectious Diseases, DOI: 10.1021/acsinfecdis.7b00072
Lee, S., and Sampson, N. S. (2017) "A cleavable cyclic acetal for affinity capture, release, and conjugation", in press, Methods in Molecular Biology.
Nelson, R. K., Ya-Ping, J., Gadbery, J., Abedeen, D., Sampson, N.S., Lin, R. Z., and Frohman, M. (2017) "Phospholipase D2 loss results in increased blood pressure via inhibition of the eNOS pathway," Scientific Reports, 7, 9112, DOI: 10.1038/s41598-017-09852-4.
Huang, H., Rodolis, M. T., Bhatia, S. R., and Sampson, N. S. (2017) "Sugars require rigid multivalent displays for activation of mouse sperm acrosomal exocytosis," Biochemistry, DOI: 10.1021/acs.biochem.7b00166.
Rodolis, M., Huang, J., and Sampson, N. S. (2016) "Glycopolymer Induction of Mouse Sperm Acrosomal Exocytosis Shows Highly Cooperative Self-Antagonism," 474, 435-440. , DOI: 10.1016/j.bbrc.2016.05.003.
Charkoudian, L. K., Sampson, N. S., Kumar, K. and Kritzer, J. A. (2016) "Designing convergent chemistry curricula," Nature Chemical Biology, 12, 382–386. doi:10.1038/nchembio.2090 – Commentary Ueki, N., Wang, W., Swenson, C., McNaughton, C., Sampson, N. S., and Hayman, M. J. (2016) "Synthesis and Preclinical Evaluation of a Highly Improved Anticancer Prodrug Activated by Histone Deacetylases and Cathepsin L," Theranostics, 6, 808-816. DOI:10.7150/thno.1382
Parker, K. A., Sampson, N. S. (2016) "From ROMP to AROMP: using substituted cyclobutenes to precisely control polymer structure," Accounts of Chemical Research. 49, 408-417. DOI: 10.1021/acs.accounts.5b00490.
Lu, R, Schmitz, W., and Sampson, N. S. (2015) "α-Methyl Acyl CoA racemase provides Mycobacterium tuberculosis catabolic access to cholesterol esters," Biochemistry, 54, 5669-5672. DOI: 10.1021/acs.biochem.5b00911
Touchette, M. H., Bommineni, G. R., Delle Bovi, R. J., Gadbery, J. E., Nicora, C. D., Shukla, A. K., Kyle, J. E., Metz, T. O., Martin, D. W., Sampson, N. S., Miller, W. T., Tonge, P. J., and Seeliger, J. C. (2015) "Diacyltransferase activity and chain length specificity of Mycobacterium tuberculosis PapA5 in the synthesis of alkyl β-diol lipids," Biochemistry, 54, 5457-5468. DOI: 10.1021/acs.biochem.5b00455
Lee, S., Wang, W., Lee, Y. and Sampson, N. S. (2015) "Cyclic acetals as cleavable linkers for affinity capture," Organic and Biomolecular Chemistry, 13, 8445-8452. DOI: 10.1039/C5OB01056J
Tan, L., Li, G., Parker, K. A. and Sampson, N. S. (2015) "Ru-catalyzed isomerization provides access to alternating copolymers via ring-opening metathesis polymerization," Macromolecules, 48, 4793-4800. DOI: 10.1021/acs.macromol.5b01058
Yang, M., Lu, R. Guja, K. E., Wipperman, M., St. Clair, J. Bonds, A., Garcia-Diaz, M. And Sampson, N. S. (2015) "Unraveling cholesterol catabolism in Mycobacterium tuberculosis: the ChsE4-ChsE5 α2β2 acyl-CoA dehydrogenase initiates β-oxidation of 3-oxo-cholest-4-en-26-oyl CoA," ACS Infectious Disease, 1, 110-125. DOI: 10.1021/id500033m
Schaefer, C., Lu, R., Nesbitt, N. M., Schiebel, J. Sampson, N. S., and Kisker, C. (2015) "FadA5 a thiolase from Mycobacterium tuberculosis – a unique steroid-binding pocket reveals the potential for drug development against tuberculosis," Structure, 23, 21-33. DOI: 10.1016/j.str.2014.10.010See Commentary
Yang, M., Guja, K. E., Thomas, S. T., Garcia-Diaz, M. And Sampson, N. S. (2014) "A distinct MaoC-like enoyl-CoA hydratase architecture mediates cholesterol catabolism in Mycobacterium tuberculosis," ACS Chemical Biology,9, 2632-2645 DOI: 10.1021/cb500232h
Tan, L., Parker, K., and Sampson, N. S. (2014) "A Bicyclo[4.2.0]octene-derived monomer provides completely linear alternating copolymers via alternating ring-opening metathesis polymerization (AROMP)," Macromolecules, 47, 6572-6579 DOI: 10.1021/ma5012039
Wipperman, M., Sampson, N. S., and Thomas, S. T. (2014) "Pathogen "Roid Rage": Cholesterol Utilization by Mycobacterium tuberculosis,"CRC Critical Reviews in Biochemistry, 49, 269-293 DOI 10.3109/10409238.2014.895700.
Gao, J. and Sampson, N. S. (2014) "A GMC Oxidoreductase Homolog is Required for Acetylation of Glycopeptidolipid in Mycobacterium smegmatis," Biochemistry53, 611-613 DOI: 10.1021/bi4015083
Wu, L., and Sampson, N. S. (2014) "Fucose, Mannose and β-N-Acetylglucosamine Glycopoly-mers Initiate the Mouse Sperm Acrosome Reaction Through Convergent Signaling Pathways," ACS Chem. Biol.9, 468-475 DOI: 10.1021/cb400550j
Evensen N.A., Li J., Yang J., Yu X., Sampson N.S., Zucker, S., Cao, J. (2013) "Development of A High-throughput Screening Invasion Assay for Anti-Cancer Drug Discovery," PLoS One, 8(12): e82811. DOI: 10.1371/journal.pone.0082811
Ueki, N. Lee, S. Sampson, N. S., Hayman, M. J. (2013) "Selective cancer targeting with prodrugs activated by histone deacetylase and tumour-associated protease," Nature Comm., 4, 2735-2742. DOI: 10.1038/ncomms3735
Commentary: New Scientist Genetic Engineering and Biotech News
Romulus, J., Tan, L., Weck, M., Sampson, N. S. (2013) "Alternating ROMP copolymers containing charge-transfer units," ACS Macro Letters, 2, 749-752. DOI: 10.1021/mz4002673
Wipperman, M.F., Yang, M., Thomas, S.T., Sampson, N.S. (2013) "Shrinking the FadE proteome of Mycobacterium tuberculosis: Insights into cholesterol metabolism through identification of an α2β2 heterotetrameric acyl-CoA dehydrogenase family," J Bacteriol. 195 (19): 4331-41. DOI: 10.1128/JB.00502-13 See commentary at DOI: 10.1128/JB.00867-13
Su, C.Y., London, E., Sampson, N.S. (2013) "Mapping peptide thiol accessibility in membranes using a quaternary ammonium isotope-coded mass tag (ICMT)," Bioconjug Chem. 24 (7), pp 1235–1247. DOI: 10.1021/bc400171j
Thomas, S.T., Sampson, N.S. "Mycobacterium tuberculosis utilizes a unique heterotetrameric structure for dehydrogenation of the cholesterol side chain," Biochemistry, (2013), 52, 17, 2895-904. DOI: 10.1021/bi4002979
Slayden, R.A., Jackson, M., Zucker, J., Ramirez, M.V., Dawson, C.C., Crew, R., Sampson, N.S., Thomas, S.T., Jamshidi, N., Sisk, P., Caspi, R., Crick, D.C., McNeil, M.R., Pavelka, M.S., Niederweis, M., Siroy, A., Dona, V., McFadden, J., Boshoff, H., Lew, J.M. (2013) "Updating and curating metabolic pathways of TB," Tuberculosis, 93, 1, 47-59. DOI: 10.1016/j.tube.2012.11.001
Thomas, S.T., VanderVen, B.C., Sherman, D.R., Russell, D.G., Sampson, N.S. "Pathway profiling in Mycobacterium tuberculosis: elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism," J. Biol. Chem, (2011), 286, 51, 43668-78. DOI: 10.1074/jbc.M111.313643
Zarrabi, K.; Dufour, A.; Li, J; Kuscu, C.; Kozarekar, P.; Zhi, J.; Sampson, N. S.; Zucker, S.; Cao, J. (2011) "Inhibition of matrix metalloproteinase-14 (MMP-14)-mediated cancer cell migration," J. Biol. Chem., 286, 38, 33167-77. DOI: 10.1074/jbc.M111.256644
Dufour, A.; Sampson, N. S.; Rizzo, R; DeLeon, J; Li, J; Kuscu, C.; Zhi, J.; Jaber, N.; Liu, E.; Zucker, S.; Cao, J. (2011) "Small molecule anti-cancer therapy selectively targets the hemopexin domain of matrix metalloproteinase-9 (MMP-9)," Cancer Res., 71, 4977-4988. DOI: 10.1158/0008-5472.CAN-10-4552
Thomas, S.; Yang, X.; Sampson, N. S. (2011), "Inhibition of the M. tuberculosis 3Beta-Hydroxysteroid Dehydrogenase by Azasteroids," Bioorg. Med. Chem. Lett., 21, 2216-2219. DOI: 10.1016/j.bmcl.2011.03.004
Song, A.; Walker, S. G.; Parker, K. A.; Sampson, N. S. (2011) "Antibacterial studies of alternating, random and homo-polymers with varied positions of cationic side chains," ACS Chem. Biol., 6, 590-599. DOI: 10.1021/cb100413w
Yang, X.; Gao, J.; Smith, I.; Dubnau, E.; Sampson, N. S. (2011), "Cholesterol Is not an essential source of nutrition for Mycobacterium tuberculosis during infection," J. Bact., 193, 1473-147. DOI: 10.1128/JB.01210-10
Dufour, A., Sampson, N. S., Kuscu, C., Zucker, S. and Cao, J. (2010) "Roles of MMP-9 homodimer and heterodimer in cell migration,"J. Biol. Chem., 285, 35944-56. DOI: 10.1074/jbc.M109.091769
Song, A.; Parker, K. A.; Sampson, N. S. (2010) "Cyclic alternating ROMP (CAROMP). Rapid access to functionalized cyclic polymers,"Org. Lett. 12, 3729-3731. DOI: 10.1021/ol101432m
Song, A.; Lee, J.; Parker, K. A.; Sampson, N. S. (2010) "Scope of the ring opening metathesis polymerization (ROMP) reaction of 1-substituted cyclobutenes," J. Am. Chem. Soc., 132, 10513–10520. DOI: 10.1021/ja1037098
Nesbitt, N. M.*; Yang, X.*; Fontán, P.; Kolesnikova, I.; Smith, I.; Sampson, N. S.*; Dubnau, E.* (2010) "A thiolase of M. tuberculosis is required for virulence and for production of androstenedione and androstadienedione from cholesterol," Infect. Immun., 78. 275-282. *co-authors DOI: 10.1128/IAI.00893-09
Lyubimov, A. Y.; Chen, L.; Sampson, N. S.; Vrielink, A. (2009) "A hydrogen-bonding network is important for oxidation and isomerization in the reaction catalyzed by cholesterol oxidase," Acta Crys. D, 65, 1222-1231. DOI: 10.1107/S0907444909037421
Kreit, J; Sampson, N. S. (2009) "Cholesterol oxidase: Physiological functions," FEBS,276, 6844-6856. DOI: 10.1111/j.1742-4658.2009.07378.x
Yang, X.; Nesbitt, N. M.; Dubnau, E.; Smith, I.; Sampson, N. S. (2009), "Cholesterol metabolism increases the metabolic pool of propionate in M. tuberculosis," Biochemistry, 48, 3819-3821. DOI: 10.1021/bi9005418
Baessler, K.; Lee, Y.; Sampson, N. S. (2009) "Beta1 Integrin is an adhesion protein for sperm binding to eggs," ACS Chem. Biology, 4, 357-366. DOI: 10.1021/cb900013d
Song, A..; Parker, K.*; Sampson, N. S.* (2009) "Synthesis of copolymers by alternating romp (AROMP)," J. Am. Chem. Soc., 131, 3444–3445. DOI: 10.1021/ja809661k
Lee, Y.; Sampson, N. S. (2009) "Polymeric ADAM protein mimics interrogate mammalian sperm-egg binding," ChemBioChem, 10, 929-937. DOI: 10.1002/cbic.200800791
Dufour, A.; Sampson, N. S.; Zucker, S.; Cao, J. (2008) "Role of the hemopexin domain of matrix metalloproteinase-9 in cell migration," J. Cell Physiol., 217, 643-651. DOI: 10.1002/jcp.21535
Elalami, A; Baessler, K.; Kong, F.; Sampson, N. S.; Kreit, J. (2008) "Subcellular forms of cholesterol oxidase from Rhodococcus sp. CIP 105 335: induction, solubilization and characterization," in Current Research Topics in Applied Microbiology and Microbial Biotechnology, World Scientific Publishing.
Chen, L.; Lyubimov, A. Y.; Vrielink, A.; Sampson, N. S. (2008) "The binding and release of oxygen and hydrogen peroxide are directed by a hydrophobic tunnel in cholesterol oxidase.," Biochemistry, 47, 5368–5377. DOI: 10.1021/bi800228w
Sampson, N. S. and Kwak, S. (2008) " Catalysis at the membrane Interface: Cholesterol oxidase as a case study", in Proceedings of the 3rd International Beilstein Workshop on Experimental Standard Conditions of Enzyme Characterizations. Beilstein, Germany. DOI: n/a
Yang, X; Dubnau, E. Smith, I; Sampson, N. S. (2007) "Rv1106c from Mycobacterium tuberculosis is a 3b-hydroxysteroid dehydrogenase,"Biochemistry,46, 9058-9067. DOI: 10.1021/bi700688x
Nesbitt, N. M.; Sampson, N.S. (2007) "Antifungal Tradecraft by Cholesterol Oxidase," Chem. Biol. 14, 238-241. DOI: 10.1016/j.chembiol.2007.03.003
Lyubimov, A. Y.; Heard, K. Tang, H.; Sampson, N. S; Vrielink, A. (2007) "Distortion of flavin geometry linked to ligand binding in cholesterol oxidase," Protein Science, 16, 2647-2656. PMC2222809
Kempf, J. G.; Jung, J-y.; Ragain, C.; Sampson, N. S.; Loria, J. P. (2007) "Dynamic requirements for a functional protein hinge," J. Mol. Biol.368, 131-149. DOI: 10.1016/j.jmb.2007.01.074
Lee, Y.; Baessler, K.; Sampson, N. S. (2006) "ROMP of norbornyl oligopeptides: A versatile synthetic method for exploring receptor topology," in Understanding Biology Using Peptides, S. Blondelle, ed., American Peptide Society (2005), 59-60. DOI:
Lee, Y.; Sampson, N. S. (2006) "ROMPing the Cellular Landscape: Linear Scaffolds for Molecular Recognition," Curr. Opin. Struct. Biol. 16, 544-550. DOI: 10.1016/j.sbi.2006.05.015
Lee, J; Parker, K. L.*; Sampson, N. S.* (2006) "Amino Acid-Bearing ROMP polymers with a Stereoregular Backbone," J. Am. Chem. Soc. 128, 4578-4579. DOI: 10.1021/ja058801v
Baessler, K.; Lee, Y.; Roberts, K. S.; Facompre, N.; Sampson, N. S. (2006) "Multivalent fertilin beta oligopeptides: the dependence of fertilization inhibition on length and density," Chem. Biol. 13, 251-259. DOI: 10.1016/j.chembiol.2005.12.010
Lee, Y.; Sampson, N. S.; (2006) "ROMPing the Cellular Landscape: Linear Scaffolds for Molecular Recognition," Curr. Opin. Struct. Biol. 16, 544-550. DOI: 10.1016/j.sbi.2006.05.015
Baessler, K.; Lee, Y.; Sampson, N.S. (2005) "ROMP of norbonyl oligopeptides: A versatile synthetic method for exploring receptor topology, "in Understanding Biology Using Peptides, S. Blondelle, ed. American Peptide Society,59-60. DOI:
Roberts, S. K.; Sampson, N. S. (2004) "A Facile Synthetic Route Leading to Fluorescently Labeled ROMP Polymers," Org. Lett., 6, 3253-3255. DOI: 10.1021/ol048935y
Xiang, J.; Jung, J-y.; Sampson, N. S. (2004) "Entropy Effects on Protein Hinges: the Reaction Catalyzed by Triosephosphate Isomerase,"Biochemistry, 43, 11436-11445. DOI: 10.1021/bi049208d
Kursula, I.; Salin, M.; Sun, J.; Borledge, B.; Haapalainen, A.; Sampson, N. S.; Wierenga, R. K. (2004) "Understanding Protein Lids: Structural Analysis of Active Hinge Mutants in Triosephosphate Isomerase," Prot. Engineering, Design Selection, 17, 375-382. DOI: 10.1093/protein/gzh048
Xiang, J.; Sampson, N. S. (2004) "Library Screening Studies to Investigate Substrate Specificity in the Reaction Catalyzed by Cholesterol Oxidase," Prot. Engineering, Design Selection, 17, 341-348. DOI: 10.1093/protein/gzh041
Konkar, S.; Gupta, S.; Sampson, N. S. (2004) "Fertilinb Liposomes Inhibit In Vitro Fertilization by Steric Stabilization," Bioorg. Med. Chem. Lett. 4, 1381-1384. DOI:
Ahn, K-w.; Sampson, N. S. (2004) "Cholesterol Oxidase Senses Subtle Changes in Lipid Structure," Biochemistry 43, 827-836. DOI: 10.1021/bi035697q
Vrielink, A.; Sampson, N. S.; (2003) "Sub-Ångstrom Resolution Protein Structures: Is Seeing Believing?," Curr. Opin. Struct. Biol. 13, 709-713. DOI: 10.1016/j.sbi.2003.10.012
Kempf, J. G.; Jung, J-y.; Sampson, N. S.; Loria, J. P. (2003) Off-Resonance TROSY (R1p-R1) for Quantitation of Fast Exchange Processes in Large Proteins," J. Am. Chem. Soc. 125, 12064-12065. DOI: 10.1021/ja037101s
Sampson, N. S.; Vrielink, A. (2003) "Cholesterol Oxidases: A Study of Nature's Approach to Protein Design," Acc. Chem. Res 36, 713-722. DOI: 10.1021/ar9800587
Roberts, S. K.; Konkar, S.; Sampson, N. S. (2003) "Comparison of Fertilinb Peptide-Substituted Polymers and Liposomes as Inhibitors ofIn Vitro Fertilization," ChemBioChem 4, 1229-1231. DOI: 10.1002/cbic.200300672
Lario, P.; Sampson, N.S.; Vrielink, A. (2003) "Sub-atomic resolution crystal structure of cholesterol oxidase: What atomic resolution crystallography reveals about enzyme mechanism and the role of the FAD cofactor in redox activity," J. Mol. Biol. 326 1635-1650. DOI:
Roberts, S.K.; Sampson, N. S. (2003) "Increased Polymer Length of Oligopeptide-substituted Polynorbornenes using LiCl," J. Org. Chem.68, 2020-2023. DOI:
Ye, Y.; Liu, Pingsheng; Anderson, R.; Sampson, N. S. (2002) "Construction of a Catalytically Inactive Cholesterol Oxidase Mutant: Investigation of the Interplay Between Active Site Residues Glutamate 361 and Histidine 447," Arch. Biochem Biophys. 402, 235-242. DOI:
Li, H.; Sampson, N. S. (2002) "Structural Analysis of Cyclic Peptide Fertilinb Mimics That Are Ligands for a6b1 Integrin," J. Pep. Res. 59, 49-54. DOI:
Gupta, S.; Sampson, N. S. (2001) "Dimyristoylated Peptides Incorporated into Lipsomes Are Polyvalent Fertilinb Mimics," Org. Lett. 3, 3333-333. DOI:
Sampson, N. S. (2001) "The Emerging Global Paradigm for Scientific Research," in New Voices in Chemistry, Chem. Eng. News, 26 Mar 2001, p. 187. DOI:
Ye, Y.; Lario, P. Vrielink, A.; Sampson, N. S. (2001) "Structural and Kinetic Analysis of the Role of Asn485 in the Reaction Catalyzed by Cholesterol Oxidase," Biochemistry, 40, 13779-13787. DOI:
Sampson, N.S.; Mrksich, M.; Bertozzi, C.R. (2001) "Surface Molecular Recognition," Proc. Nat. Acad. Sci. U.S.A. 98, 12870-12871. DOI:
Sampson, N. S.; Sarah T. Ryan; Deborah A. Enke; Dominic Cosgrove; Victor Koteliansky; Philip Gotwals (2001) "Global Gene Expression Analysis Reveals a Role for the a1Integrin in Renal Pathogenesis," J. Biol. Chem, 276 34182-34188. DOI:
Xiang, J; Sun, J.; Sampson, N. S. (2001) "The Importance of Hinge Sequence for Loop Function and Catalytic Activity in the Reaction Catalyzed by Triosephosphate Isomerase," J. Mol. Biol, 307, 1103-1112. DOI:
Sampson, N. S. (2001) "Dissection of a Flavo-Enzyme Active Site: the Reaction Catalyzed by Cholesterol Oxidase," Antioxidants and Redox Signalling, 3, 839-846. DOI:
Chen, X.; Wolfgang, D.; Sampson, N. S., (2000) "Use of the Parallax-Quench Method to Determine the Position of the Active-Site Loop of Cholesterol Oxidase in Lipid Bilayers," Biochemistry, 39, 13383-13389. DOI:
McCann, A.; Sampson, N. S., (2000) "A C6-FAD Adduct is Formed Upon Irreversible Inactivation of Cholesterol Oxidase by 2a,3a-Cyclopropano-5a-cholestan-3b-ol," J. Am.Chem. Soc., 122, 35-39. DOI:
Gupta, S.; Li, H.; Sampson, N. S., (2000) "Characterization of Fertilinb-Disintegrin Binding Specificity in Sperm-Egg Adhesion," Bioorg. Med. Chem., 8, 723-729. DOI:
Sun, J.; Sampson, N. S., (1999) "Understanding Protein Lids: Kinetic Analysis of Active Hinge Mutants in Triosephosphate Isomerase,"Biochemistry, 38, 11474-11481. DOI:
Yue, Q. K.; Kass, I. J.; Sampson, N. S.; Vrielink, A., (1999) "Crystal Structure Determination of Cholesterol Oxidase from Streptomycesand Structural Characterization of Key Active Site Mutants," Biochemistry, 38, 4277-4286. DOI:
Chen, H.; Sampson, N.S., (1999) "Mediation of Mammalian Sperm-Egg Fusion: Evidence That Mouse Egg a6b1 Integrin is the Receptor for Sperm Fertilinb," Chem. Biol., 6, 1-10. DOI:
Kass, I. J.; Sampson, N. S., (1998) "Evaluation of the Role of His447 in the Reaction Catalyzed by Cholesterol Oxidase,"Biochemistry, 37, 17990-18000. DOI:
Chen, H.; Pyluck, A.; Janik, M.; Sampson, N. S., (1998) "Peptides Corresponding to the Epidermal Growth Factor-like Domain of Mouse Fertilin: Synthesis and Biological Activity," Biopolymers (Peptide Science), 47, 299-307. DOI:
Kass, I. J.; Sampson, N. S., (1998) "The Importance of Glu361 Position in the Reaction Catalyzed by Cholesterol Oxidase," Bioorg. Med. Chem. Lett., 8, 2663-2668. DOI:
Sun, J.; Sampson, N. S., (1998) "Determination of the Amino Acid Requirements for a Protein Hinge in Triosephosphate Isomerase,"Prot. Science, 7, 1495-1505. DOI:
Sampson, N. S.; Kass, I. J.; Ghoshroy, K. B., (1998) "A Truncated W Loop Mutant of Cholesterol Oxidase Has Altered Substrate Specificity," Biochemistry, 37, 5770-5778. DOI:
Sampson, N. S.; Chen, X., (1998) "Improved Expression of Brevibacterium sterolicum Cholesterol Oxidase in Escherichia coli by Genetic Modification," Prot. Exp. Purific., 12, 347-352. DOI:
Sampson, N. S.; McCann, A. E., (1997) "4,5-Cyclopropano-Cholestan-3b-Ol Substrates for Cholesterol Oxidase and Their 1H NMR Assignments, " J. Org. Chem., 62, 5893 -5897. DOI:
Pyluck, A.; Ruiyong, Y.; Galligan Jr, E.; Primakoff, P.; Myles, D. G.; Sampson, N. S., (1997) "ECD Peptides Inhibit In Vitro Fertilization in Mice," Bioorg. Med. Chem. Lett., 7, 1053-1058. DOI:
Ghoshroy, K. B.; Zhu, W.; Sampson, N. S., (1997) "Investigation of Membrane Disruption in the Reaction Catalyzed by Cholesterol Oxidase," Biochemistry, 36, 6133-6140. DOI:
Sampson, N. S.; Kass, I. J., (1997) "Isomerization but not Oxidation is Suppressed by a Single Point Mutation, E361Q, in the Reaction Catalyzed by Cholesterol Oxidase," J. Am. Chem. Soc., 119, 855-862. DOI:
Kass, I. J.; Sampson, N. S., (1995) "The Isomerization Catalyzed by Brevibacterium sterolicum Cholesterol Oxidase Proceeds Stereospecifically with One Base," Biochem. Biophys. Res. Commun., 206, 688-693. DOI:
Sampson, N. S.; Knowles, J. R., (1992) "Segmental Motion in Catalysis: Investigation of a Critical Hydrogen Bond for Loop Closure in the Reaction of Triosephosphate Isomerase," Biochemistry, 31, 8488-8494. DOI:
Sampson, N. S.; Knowles, J. R., (1992) "Segmental Movement: Definition of the Structural Requirements for Loop Closure in Catalysis by Triosephosphate Isomerase," Biochemistry, 31, 8482-8487. DOI:
Sampson, N. S.; Bartlett, P. A., (1991) "Attempted de Novo Design, Synthesis, and Evaluation of a Ligand for the Allosteric Site of Phosphofructokinase," J. Org. Chem. 56, 7179-7183. DOI:
Bone, R.; Sampson, N. S.; Bartlett, P. A.; Agard, D. A., (1991) "Crystal Structures of a-Lytic Protease Complexes with Irreversibly Bound Phosphonate Esters," Biochemistry 30, 2263-2272. DOI:
Sampson, N. S.; Bartlett, P. A., (1991) "Peptidic Phosphonylating Agents as Irreversible Inhibitors of Serine Proteases and Models of the Tetrahedral Intermediates," Biochemistry 30, 2255-2263. DOI:
Sampson, N. S.; Bartlett, P. A., (1988) "Synthesis of Phosphonic Acid Derivatives by Oxidative Activation of Phosphinate Esters," J. Org. Chem. 53, 4500-4503. DOI:
Romoff, T. T.; Sampson, N. S.; van Eikeren, P., (1987) "Regioselectivity and Kinetics of Hydride Transfer in Substituted 1-Benzyl-3-quinolinecarboxamide Redox Reactions," J. Org. Chem. 52, 4454-4459. DOI:


humans because they lacked a certain intangible quality reason, moral agency, or consciousness that. Cozy games help player practice fulfilling higher order needs : Cozy games also fulfill player needs. These high level principles provide direction and framing for designing a cozy or cozier game. However, a fundamental mechanic or motivation can engender a positive or negative sense of coziness, and contribute to the overall tone and feel of the game. The response is to create safety such that there is less need for defensive behavior. We encourage developers to build cozy games. tags: Animal Testing, Animals, Animal rights Good Essays 479 words (1.4 pages) Preview - "Ask the experimenters why they experiment on animals, and the answer is: 'Because the animals are like.' Ask the experimenters why it is morally OK to experiment on animals. In Animal Crossing, the sounds of shaking trees to get fruit is inherently pleasurable even after thousands of repetitions. Or sewing a quilt for a child you love. This is a space of safe social connection. Intentionally evoke images of safety, softness, and contentedness. There is no place to use the bathroom, other than where you stand.
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The campaign for justice for Pat Finucane and many more will go on
4th December 2020 shoreditchadmin2 British Politics, Ireland, Slider 0
Pat Finucane mural in Belfast
Earlier this week the British government announced that it would not call a public inquiry into the assassination of Pat Finucane. The minister lied, claiming that there were ongoing investigations being conducted by the Police Service of Northern Ireland (PSNI). Both the Police Ombudsman and the PSNI itself immediately denied that there are any ongoing investigations.
The facts of the case and many more like it are well known. British security forces in Ireland established, armed, staffed and funded Loyalist death squads. Eight years ago David Cameron admitted that there "shocking levels of collusion" between the State forces and the assassination gangs. What has yet to be established is the extent of the official involvement in this conspiracy. John Finucane, Pat's son who saw him murdered in their family home, said, "We know who pulled the trigger. We need to know who pulled the strings."
Reproduced below is the letter set to the British Minister Brandon Lewis by the leaders of the four non-Unionist political parties in the NI Assembly. The struggle for justice for Pat Finucane and many others will go on.
Dear Brandon,
We last wrote on 22 November 'calling on you, and the British government, to act in the public interest and hold a Public Inquiry into the 1989 killing of Pat Finucane.' 31 years after the murder, and 20 years after the Weston Park commitments, your decision yesterday not to order a public inquiry – citing that other review processes needed to be completed – is neither a credible nor tenable position.
It was an insult to the Finucane Family.
Your approach to this matter is now a matter of serious public concern.
To avoid a public inquiry, you have clearly made a calculated decision to embark on a high-risk distraction strategy that now places both the Office of the Police Ombudsman and the PSNI in the midst of a historic murder investigation at a time when the intent is to taken legacy out of policing.
Your suggested approach potentially risks wider confidence in the rule of law and the administration of justice.
The responses from both organisations to your decision are instructive. The Office of the Police Ombudsman has said that: 'at this stage events connected to the murder of Pat Finucane are not central to any of our ongoing investigations', and alongside that the PSNI Chief Constable Simon Byrne has that there were 'currently no new lines of inquiry'.
Both responses raise serious questions about your decision, your approach and why you have rejected a public inquiry. This is particularly at a time when you have also not made any progress towards the implementation of the Stormont House Agreement's legacy mechanism.
We still hold that a public inquiry is the most effective option to get the truth about the scope and extent of state collusion into Pat's killing. You must in the public interest reconsider your response to the Supreme Court ruling.
We therefore call on you again, and the British government, to reconsider your decision and hold a Public Inquiry into the 1989 killing of Pat Finucane.
Michelle O'Neill MLA, Sinn Féin
Colum Eastwood MP, Social Democratic and Labour Party
Stephen Farry MP, Alliance Party
Claire Bailey MLA, Green Party
Pat Finucane
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Britain's military infrastructure – for the new cold war


Texas has made headlines in Planned Parenthood-related news once again for being one of the first states in the nation to open an investigation into the criminal activity of the abortion giant's affiliates in the state.
Several investigations will work simultaneously to scrutinize Planned Parenthood from multiple angles in Texas, and the first one to kick off is being conducted by the Texas Senate Committee on Health and Human Services.
The Committee began their investigation with a hearing with the purpose, as relayed by pro-life Senate Chairman, Senator Charles Schwertner (pictured right), of examining current regulations in place by the Department of State Health and Human Services and to evaluate current statutes of fetal tissue donation in the state of Texas.
Among invited witnesses was John Seago, Legislative Director of Texas Right to Life, who has worked with the Texas Legislature for years to uncover illegal activity within Planned Parenthood and help pro-life elected officials heed their constituents' desire to defund the abortion conglomerate in Texas. To that end, Seago has helped legislators craft successful legislation which has to date redirected over $80 million away from Planned Parenthood and into more worthy state programs since 2011. The legal strategy of Texas Right to Life has ensured that women's health is always a top priority in these redirections of funding, and as a result, Texas women now have more non-abortion-provider resources for health care than ever before.
Seago explained to the Committee that Planned Parenthood is still being funded, however, through three streams that could be blocked in one fell swoop: through a funding overlay to the State Budget which would prevent any line item allocations of taxpayer funding to any abortion provider in the state of Texas. He also noted that the current Planned Parenthood scandal – just one of many in Texas, including multiple instances of Medicaid fraud – can be bandaged with pre-abortion consent reforms and a ban on fetal tissue harvesting in the state of Texas. But a less myopic view of the abortion behemoth reveals that the root problem is the legality of dismemberment abortion. Seago proposed a Dismemberment Abortion Ban as a more comprehensive solution to the larger brutality from which fetal tissue harvesting stems.
Planned Parenthood opted not to appear at the hearing, except to briefly present a letter in which the abortion giant expressed its disdain for the humane motives that catalyzed the investigation (namely, concern for the preborn, for their mothers, and for the law). The letter echoed the attitude and sentiments of Planned Parenthood president Cecile Richards, who has repeatedly denied factual evidence of wrongdoing and deflected scrutiny by talking about "services" that have nothing to do with abortion or fetal tissue harvesting.
Watch the full footage of the Committee hearing here, including John Seago's comments, which begin at 2:22:40.


Take just a few hours to read this book and revolutionalize the way you manage your money! It is a series of do-it-yourself seminars covering all the tenets of money. It is designed to challenge you, provoke your thinking and advice you on the best practice.
• How Wisely Do You Manage Your Money?
• Financial Planning - Whose Responsibility Is It?
• Going On An Elephant Hunting Safari!
Chapter 9 : Financial Decisions – How Decisive Are You?
• How Decisive Are You?
Chapter 10 : Financial Fitness – How Financially Well Are You?
• How Financially Fit Are You?
Mr. Cryford Mumba read Economics at The University of Zambia and graduated with Bachelor of Arts Degree. He complemented his Economics degree with the Advanced Diploma in Project Management(UK), Diploma in Banking and Financial Services(Zambia), Diploma in Marketing(UK). He then expanded his knowledge of business through the accountancy of ACCA for which he is a finalist. He holds an MBA(RSA) with a thesis Limited Access to Credit Among Women Market Traders .
Mr. Mumba is the Proprietor and Chief Executive Officer of Premier College of Banking and Finance Limited, a firm specializing in financial training and consulting. His specialist teaching areas include Financial Mathematics, Statistical Analysis, Corporate Finance, Financial Reporting and Economics. He has written extensively on Banking and Finance course. He is the author Understanding Financial Mathematics, Understanding Statistical Analysis and a host of other Banking and Financial Services training manuals. He is also the Editor of The Student Banker Magazine and a columnist on financial matters for Business Analysis Newspaper.
He resides in Lusaka, married and is a supporter of Arsenal Football Club.
There are a few observations that may help the reader through the pages ahead. The data on which this book is based is distilled into ten chapters which form the core tenets of managing money wisely. Some readers may say that these headings are motherhoods, but that's not true. Each chapter in and of itself may seem a platitude, but the intensity of the way in which excellent money managers execute them is as rare as an eclipse of the moon. Further, though some business ideas have been presented in some sections of the book, there has been a limit as to how far I could expound this area because this is not a 'business book' but a 'money book' of which money can come from different sources.
To get the most of the book, I recommend that you go through the chapters in the exact manner they are organized. This is because each chapter is exceptional and is a guidepost to the next chapter. This is regardless of your comfort because each chapter will challenge, provoke and advise you-triple benchmark-which I have used to good effect to my banking students as a lecturer.
• Challenge - The book will challenge the manner you have been managing your money until now. When strongly challenged, do not think of giving me a 'red card' because am inherently immune from it. Just take note!
• Provocation - This book will provoke you to thing and think deeply on your personal circumstances, to correctly understand your strengths and weaknesses with regards to how you manage your money.
• Advice - This book will also advise you on best practice. This is what has been proven to work for individuals committed to wise money management. The advice given can be accepted or rejected and the choice is entirely yours to make. After all, a person who accepts advice is still the one who makes decisions.
The book provides a learning experience that combines admonition with practical illustrative examples. The book prides itself on making the seminars practical and responsive to the reader's needs and emphasizes individual action plan development, and useful quotations to motivate you. This approach ensures an experience that you will find rewarding and technically useful in your individual capacities whatever your station in life.
The book is a special offer to any individual who wants to improve his/her skills and abilities in managing money wisely and achieve life fulfillment. It is directed at individuals whether they own conglomerates, small businesses, salaried employees, politicians, church members, farmers, street vendors, marketeers, students, retirees and any body who has a sense of money.
A book like this is not only a product of current research and colleagues. My predisposition is a product of lifetime. In that vein, I owe special thanks to my mother, Janet Mumba, who shaped my early notions of excellence, and my late father, Nelson Mumba, (RIP) who taught me the values of initiative and enterprising spirit through personal example. Finally, but not the least 'hat off' to my wife -Nivea - for her unwavering support to the project.
Sophocles, the ancient Greek playwright, had a very strong opinion of the role of money. As he saw it, of all evils upon the earth, the worst is money. It is money that sacks cities, and drives men forth from hearth and home; warps and seduces native intelligence, and breeds a habit of dishonesty.
In modern times, people are still seduced by the lure of money and fashion their lives around its pursuit. Money bewitches people. They fret for it, and they sweat for it. They devise most ingenious ways to get it, and most ingenious ways to get rid of it. Money is the only commodity that is good for nothing but to be gotten rid of. It will not feed you, cloth you, shelter you, or amuse you unless you spend it or invest it. It imparts value only in parting. People will almost do anything for money, and money will do almost anything for people. Money is a captivating, circulating, masquerading puzzle.
1. Find a quit place where you can work undisturbed for ten minutes.
2. On the following list of twenty words, to the right of each word, jot down an abstract symbol that signifies what feelings the word evokes for you. Use lines, circles, spirals, arrows and the like.
3. If you hesitate on a word, indicate that with a tick to the left of the word. Take a moment to think of a symbol. If no ideas come to you, move on.
When you have completed the money symbols test, connect similar symbols with a line. Work with one shape at a time. For example, for money, for perfect, √ for assertive, Ξ for budget, and so on can be used. A big circle for money would mean an expanded sense of money in which you believe anything is possible. (Note: there is no correct or incorrect symbol here, it all depends on your feeling with the word).
Having completed the money symbols test, proceed to read the following factual cases and identify the involved persons' relationship with money.


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A REMINDER ON THE LATEST EMPLOYMENT RELATIONS ACT CHANGES
OUR MERGER
RISING COSTS OF PRIVACY BREACHES
In March this year, the Human Rights Review Tribunal ("HRRT") awarded a woman $98,000.00 for injury to feelings from a privacy breach involving her previous employer. This sends a clear warning that privacy is no trivial matter.
The woman in question had posted a picture on social media of a cake she had baked for a private dinner party, which featured the name of her previous employer and several profanities. Her friends on Facebook (150 people) would have been able to see it.
Her previous employer became aware of the picture and obtained a screenshot of the cake, which was then circulated by the ex-employer around recruitment agencies. The employer also sent an internal email to employees setting out background to the ex-employee's resignation and pressured her new employer to terminate her employment.
In cases before the Employment Relations Authority, it is very rare to see awards for injury to feelings above $30,000.00. However, the HRRT awarded $98,000.00 to the woman for injury to feelings. The HRRT was aware that this was a new benchmark award and made comment that award levels need to move as understanding of the law develops and in accordance with changes of perception and economic factors, such as inflation.
The Tribunal has recognised some informal banding systems for low awards (up to $10,000.00), medium ($10,000.00 – $50,000.00) and high (above $50,000.00).
In this particular case, there was no current employment arrangement between the parties to the complaint before the HRRT. However, the level of the award granted by HRRT may see employees choose that forum over the Employment Relations Authority where there is a complaint over something which is actionable in both forums such as discrimination cases.
With the signalling of significantly increased awards in the Human Rights Review Tribunal, employers and others need to be particularly mindful about personal rights to privacy and non-discrimination and not treat those lightly.
HRRT decisions are accessible on line from the Ministry of Justice website which also has a schedule of awards granted.
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Heather K. Gerken Reappointed Dean of Yale Law School
Dean Heather K. Gerken was reappointed to a second five-year term on Jan. 19, 2022. The renewal recognizes her tireless work strengthening the School's tradition of academic excellence, fortifying support for the student body, and launching new innovative programming, among many other contributions.
Q&A: LEAP Grant Recipient Grace Cajski
Report: Computers Make Critical Decisions for CT Agencies; How That Works is Kept Secret
World Bank Chief Economist to Deliver 2022 Raben Lecture on Feb. 7
Q&A: Liman Fellow Sophie Angelis '21 on Making Prison More Dignified, Less Painful
Liman Summer Fellow Encounters a Familiar Housing Injustice
Yale Law School Mourns the Loss of Howard Solomon '52
Rethinking "Rules of the Road" to Stabilize U.S.-China Competition — A Commentary by Robert D. Williams
Robert D. Williams is a Lecturer in Law, Senior Research Scholar in Law, and the Executive Director of the Paul Tsai China Center at Yale Law School.
Richard Nixon's War on Cancer Has Lessons for Biden's New Push Against the Disease — A Commentary by Abbe R. Gluck '00 and Eugene Rusyn '17
Abbe R. Gluck is the Alfred M. Rankin Professor of Law at Yale Law School. Eygene Rusyn '17 is Associate Research Scholar with the Solomon Center for Health Law and Policy.
Carmen Reinhart, Senior Vice President and Chief Economist of The World Bank Group, will deliver a lecture titled "Central Banks and the Inflationary Aftermath of COVID-19" on Feb. 7, 2022.
Professor Monica Bell '09 Receives AALS Derrick A. Bell Jr. Award
(left to right) Mei Lin Kwan-Gett '92, Joanna C. Hendon '91, and Dani R. James '95 have sustained a friendship for decades since working together as prosecutors early in their careers.
Decades-Long Friendship Sustains Litigators
Yale Law School Mourns the Loss of Lani Guinier '74
Spring Term to Start Remotely on January 24
January 21 Friday
Keywords: CLS 'Political Economy' and 'Indeterminacy'
January 24 Monday
Spring term begins; Classes begin, 8:10 a.m.
YLS
Add/drop period begins, 8:30 a.m.
DOJ Criminal Fraud Section Career Talk
January 25 Tuesday
Winter Interview Program (WIP)
Seeing Human Rights: Video Activism as a Proxy Profession, Sandra Ristovska, University of Colorado Boulder
Office of Management and Budget Q&A Session
January 26 Wednesday
Faculty Perspectives on Clerkships
January 27 Thursday
Live Meditation
Legal Theory Workshop
Lead in Many Dimensions
Illuminate Unconventional Paths
Expand Excellence
Everything You Want to Know about Yale Law School: The 250 Word Essay
Everything You Want to Know about Yale Law School: Personal Statements
Campus Division? Dispute Resolution Strategies for Campus Leaders
Fourth Conference on Law and Macroeconomics, Part 1
Designing Solutions to the Eviction Crisis: Best Practices
Is Whiteness Embedded in Mediation?
How the English Language Conquered the World
John M. Duff, Jr. Professor of Law Amy Chua reviews The Rise of English by Rosemary Salomone.
Ghislaine Maxwell's Conviction Can Survive a Juror's Disclosure — A Commentary by Stephen L. Carter '79
Stephen L. Carter '79 is the William Nelson Cromwell Professor of Law at Yale Law School.
Yes, Colleges Favor Some Rich Kids. It's Just Math. — A Commentary by Stephen L. Carter '79
We're All Tired of This Pandemic—and Some of Us Are Sick — A Commentary by Gregg Gonsalves
Gregg Gonsalves is Associate Professor (Adjunct) of Law and Co-Director of the Global Health Justice Partnership at Yale Law School.
Jan. 6 Rioters Don't Face a Double Standard — A Commentary by Stephen L. Carter '79
The Holmes Verdict Sends a Mixed Message to Investors — A Commentary by Stephen L. Carter '79
3 Hurdles That Could Slow The Pace Of SPACs In 2022
Professor of Law John Morley '06 is mentioned in an article about the future of Special Purpose Acquisition Companies.


Are you interested in getting more involved in the Virginia Floodplain Management Association? VFMA is seeking nominations for five positions on the Board of Directors. Directors serve a two-year term, which will begin in March 2019.
Elections will take place electronically following the nomination period, and new board members will begin their term at the Annual Meeting held at the Virginia Water Conference in Richmond.
Click here to access the Nomination Form!
Nominations are due by COB on February 8th!
Each person may only run for ONE position. In order to serve on the Board of Directors, you must be a current VFMA member. If you're not already a VFMA member, you can become a member by registering here.
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