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Giving Transplanted Cells A Nanotech Checkup - 02/05/2013
Giving Transplanted Cells A Nanotech Checkup
Researchers devise way to safely see whether replacement cells are still alive
Release Date: February 5, 2013
Nanosensors (green spheres) are composed of fat and L-arginine molecules, as well as separate indicator molecules that give off MRI-detectable and light signals when cells are alive. Nanosensors are enclosed in a hydrogel membrane along with liver cells (pink). Nutrients and other relatively small molecules (red) are able to travel across the hydrogel membrane to and from the bloodstream.
Credit: Sayo Studios
Researchers at Johns Hopkins have devised a way to detect whether cells previously transplanted into a living animal are alive or dead, an innovation they say is likely to speed the development of cell replacement therapies for conditions such as liver failure and type 1 diabetes. As reported in the March issue of Nature Materials, the study used nanoscale pH sensors and magnetic resonance imaging (MRI) machines to tell if liver cells injected into mice survived over time.
"This technology has the potential to turn the human body into less of a black box and tell us if transplanted cells are still alive," says Mike McMahon, Ph.D., an associate professor of radiology at the Johns Hopkins University School of Medicine who oversaw the study. "That information will be invaluable in fine-tuning therapies."
Regenerative medicine advances depend on reliable means of replacing damaged or missing cells, such as injecting pancreatic cells in people with diabetes whose own cells don't make enough insulin. To protect the transplanted cells from the immune system, while allowing the free flow of nutrients and insulin between the cells and the body, they can be encased in squishy hydrogel membranes before transplantation. But, explains McMahon, "once you put the cells in, you really have no idea how long they survive." Such transplanted cells eventually stop working in most patients, who must resume taking insulin. At that point, physicians can only assume that cells have died, but they don't know when or why, says McMahon.
With that problem in mind, McMahon's group, which specializes in methods of detecting chemical changes, collaborated with the research group headed by Jeff Bulte, Ph.D., the director of cellular imaging at Hopkins' Institute for Cell Engineering. Bulte's group devises ways of tracking implanted cells through the body using MRI. Led by research fellow Kannie Chan, Ph.D., the team devised an extremely tiny, or nanoscale, sensor filled with L-arginine, a nutritional supplement that responds chemically to small changes in acidity (pH) caused by the death of nearby cells. Changes in the acidity would in turn set off changes in sensor molecules embedded in the thin layer of fat that makes up the outside of the nanoparticle, giving off a signal that could be detected by MRI.
To test how these nanosensors would work in a living body, the team loaded them into hydrogel spheres along with liver cells — a potential therapy for patients with liver failure — and another sensor that gives off bioluminescent light only while the cells are alive. The spheres were injected just under the skin of mice. As confirmed by the light signal, the MRI accurately detected where the cells were in the body and what proportion were still alive. (Such light indicators cannot be used to track cells in humans because our bodies are too large for visible signals to get through, but these indicators allowed the team to check whether the MRI nanosensors were working properly in the mice.)
"It was exciting to see that this works so well in a living body," Chan says. The team hopes that because the components of the system — hydrogel membrane, fat molecules, and L-arginine — are safe for humans, adapting their discovery for clinical use will prove relatively straightforward. "This should take a lot of the guesswork out of cell transplantation by letting doctors see whether the cells survive, and if not, when they die," Chan says. "That way they may be able to figure out what's killing the cells, and how to prevent it."
Potential applications of the sensors are not limited to cells inside hydrogel capsules, Bulte notes. "These nanoparticles would work outside capsules, and they could be paired with many different kinds of cells. For example, they may be used to see whether tumor cells are dying in response to chemotherapy," he says.
Other authors on the paper were Guanshu Liu, Xiaolei Song, Heechul Kim, Tao Yu, Dian R. Arifin, Assaf A. Gilad, Justin Hanes, Piotr Walczak and Peter C. M. van Zijl, all of the Johns Hopkins University School of Medicine.
The study was funded by the National Institute of Biomedical Imaging and Bioengineering (grant numbers R01 EB012590, EB015031, EB015032 and EB007825).
The Nature Materials paper can be found here: http://www.nature.com/nmat/journal/vaop/ncurrent/abs/nmat3525.html
New Technique Developed for Tracking Cells in the Body
Jeff Bulte on tracking cells through their journey through the body
Stem Cells May Do Best With A Little Help From Their Friends
Tracking the Elusive Stem Cell
New Technique to "See" and Protect Transplants Successful in Diabetic Animal Model
Shawna Williams; 410-955-8236; shawna@jhmi.edu
Vanessa McMains; 410-502-9410; vmcmain1@jhmi.edu
Catherine Kolf; 443-287-2251; ckolf@jhmi.edu


Opinion | The Sketch Book of Nick DeLuca.
On Tuesday, April 5, Senator Bernie Sanders of Vermont won the Wisconsin Democratic primary over fellow presidential contender Hillary Clinton, former New York senator and secretary of state, by a margin of 56.6% to 43.1%.
Wisconsin's primary could prove pivotal for Senator Sanders as he tries to oust Clinton, considered by many to be the Democratic front-runner. It was pivotal, too, for the young Massachusetts senator in 1960, John F. Kennedy, who carried the state in unlikely fashion and went on to triumph over rival Lyndon B. Johnson, the Senate Majority Leader from Texas, and assume the presidency thereby establishing a new era of American politics and enshrining the former as the insignia of unrealized political potential.


Carlos Torres held the Cardinals in check on Wednesday evening in a clean top of the eighth inning. He walked one, and struck out another batter on his way to earning his twelfth hold of the season.
If Tyler Thornburg were to find himself injured or ineffective down the stretch as a closer, Torres is the guy you want. He currently has career highs in WHIP and ERA with 1.19 and 2.91 respectively, and he has a 63/27 strikeout to walk rate over 68 innings. The walk rate is a bit high, but there aren't a ton of better options in the Brewers bullpen.


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Where to Find The Hammer of Olympus in The Outer Worlds
Centipede November 7, 2019, 2:47 pm
The Outer Worlds had recently been released on all major consoles and PC. Widely considered as a sort of spiritual successor to the highly acclaimed Fallout: New Vegas, it sets out to deliver yet another exciting adventure. Colorful and vibrant, the game is filled to the brim with secrets, most of which give you access to some of the best weapons. Such as the Hammer of Olympus.
The Hammer of Olympus is a unique weapon which has a 175 Shock DPS (Damage Per Second), which makes it very good against robots, in particular. It also possesses a unique skill "Stun," which, as the name implies, stuns enemies. It's a two-handed melee weapon capable of unleashing hell upon your enemies upon being successfully used. You can also use it to get the "Short Circuit" trophy/achievement, which asks you to "Kill 30 automechanicals with shock damage."
Where Can I Find The Hammer of Olympus?
You can find the Hammer of Olympus near the Devil Peaks Summit, which is in Southern Monarch Wilderness. You have to traverse to the area called "Sundered Rock" which won't have a fast-travel to it, so you will have to walk to it. However, it will be marked on the map so you can use that for easy access. You want to climb the place, so you reach a point where you are overlooking it. It will be in between two boulders, just lying there ready for you to take it. It is just northeast of Devil Peaks Station. Just pick the weapon up and enjoy it!
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Pregnant with a thought so vile, even abortion can't cure it. But cute 2D anime girls can. This is the Centipede, 21 years of pure horror buckled within, ready to report for action. Hopes of becoming a game designer myself. But for now, let's just settle with the fact that I'm a sentient centipede capable of human interactions.
How to Unlock all Planets in The Outer Worlds
How to Remove/Hide Your Companion's Helmet in The Outer Worlds
How to Get Access to Roseway in The Outer Worlds
How to Remove Flaws in The Outer Worlds
How to Find and Use the Holographic Shroud in The Outer Worlds
Luigi's Mansion 3: How to Find and Capture Boos & All their Locations

redpajama_set_name: RedPajamaCommonCrawl


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Discharging a political storm: Supporting EU competitiveness and innovation in the ETS
by Aleksandra Mirowicz | Jul 13, 2015 | Carbon Pricing, Europe
On Wednesday, the EU Commission will release new legislation to reform Europe's key climate policy, the EU Emissions Trading Scheme (EU ETS). This will kick off a year-long debate about how best to marry low carbon ambitions with economic competitiveness.
In our new briefing we explain how the current rules are not sufficiently encouraging major industrial emitters to invest in decarbonisation, and shares its recommendations for reform. Sandbag also launches a new interactive data tool illustrating how many spare free emissions rights industry has built up over time, and forecasting future supply balances.
The total picture of the carbon market remains one of an enormous oversupply of permits. As a whole group, European industry receives enough free permits to cover current activity levels up to 2023, and certain sectors, such as cement sector, well beyond 2030.
Figure 1. Projected carbon allowance surpluses for the ETS cement sector in all countries (a screenshot of the tool)
There is currently almost no carbon price stimulus for innovation. However, due to different trends in industrial sectors and how the rules apply, oversupply varies widely between different industry sectors and countries. Almost nobody will receive full exemption from paying a carbon price in the future. There is also currently insufficient support for industrial innovation using any technologies other than renewables.
More industrial installations are closing or reducing production in Europe than are opening. This is not due to the carbon price, but in the future tightening caps could exacerbate this trend, unless policies are introduced to properly reward investment in modernisation.
Figure 2: Number of industrial installations first emitting in each year since 2008, and registered as closed in each year; all sectors and all countries except Croatia and Iceland (a screenshot of the tool)
Figure 3: Number of industrial installations emitting in each year; all sectors and all countries except Croatia and Iceland (a screenshot of the tool)
"New technologies and approaches that can reduce greenhouse gas emissions can also boost the EU's productivity and secure inward investment" says Damien Morris, Sandbag's Policy Director. "To achieve this, the policy framework needs to be carefully balanced. We do not believe the rules for industrial sectors are balanced at the moment – they are too lax in some respects and too harsh in others. The political storm that is brewing as caps on emissions tighten needs to be discharged. Policymakers need to look carefully at the evidence, step up to the challenge and introduce the necessary changes".
To discharge the coming political storm Sandbag suggests key policy recommendations for the post-2020 period:
· More targeted distribution of free permits in the future, so those genuinely in need of protection against carbon leakage receive it;
· Less punitive application of the rules which reduce the total volume of allowances available to industry (i.e. the so-called 'cross-sector correction factor');
· A bigger focus on providing support for investments in deep decarbonisation options in industry (e.g. CCS and electrification);
· A rejection of the idea that industries with big electricity bills should receive new kinds of compensation


Hats by Iniziobella is a brand focused on fascinator hat – making in Nigeria. The client already had the choices of fuchsia, turquoise and silver as brand colours; thus Stylish, Elegant, Glamorous and Beautiful were the principles to guide our development of the brand's basic identity.
In designing a logo for a brand that created 'Hats for Ladies with Hearts', it was important that our creation be simple and feminine with a touch of subtle strength, something that said beauty and business.
Ribbons are delicate yet strong, and an essential element of hat – making, so we manipulated two strips of ribbon into a simplistic hat outline.
For font choice, we wanted something that would blend the business and artistic nature of the brand seamlessly. Myriad Pro struck the tone we were going for with its sans serif features and smooth edges.
Brand Colour Palette: Fuchsia, Turquoise and Silver.
Brand Element: Two hat ribbon strips.


It was the perfect night to be. Vanessa and Chuy tied the knot and celebrated in style together with family and friends. From the beginning we realized what it was going to be about. This couple paid so much attention to details, that nothing could go wrong that night.
A few months ago we went to Tequila town for the pre wedding session. We broke the ice so easily, as Vanessa and Chuy are very easy-going fellas and right that day, we knew this wedding was going to be so special.
Vanessa and Chuy looked so beautiful, during the whole day they just gave each other glances and kisses with love. The city of Guadalajara gave us significant scenarios and we tried to take advantage on the beautiful sunny day to later moving to The Palacio de las Vacas.
The Palacio de las Vacas is one ancient house in the Guadalajara city centre. Its rooms are fun of objects, paints, old style decorations. It's always very challenging have a session in there.
One of the distinguished aspect of the beauty of Vanessa is her tattoo which tell us lots about how she lives her love.


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Florida to provide Puerto Rico high school diplomas to eligible evacuees
Thousands of students fled the island to Florida after Hurricane Maria.
[Times | 2013]
Puerto Rican teens who evacuated after Hurricane Maria's devastation can still earn a high school diploma from their home island while completing their work in Florida, the state Department of Education has informed superintendents.
If the students fled the storm, are currently enrolled in a Florida public school and had attained 11th or 12 grade by the time Maria hit, they can pursue this option, K-12 chancellor Hershel Lyons wrote in a late December memo.
That means the students can graduate with different requirements than if they were to complete a Florida diploma. To earn a diploma in Puerto Rico, students must have minimum of 18 course credits, 20 hours of occupational experiences (which may include mentoring, internship or work experience) and 40 hours of community service.
The course credits are less restrictive than Florida's. Puerto Rico also does not mandate a minimum grade-point average, and it does not have an exit-level standardized testing component.
Education commissioner Pam Stewart reached out to her counterpart in Puerto Rico in November to make this arrangement possible. The state is coordinating with Puerto Rico to get student credits transferred and to get transcripts delivered.
"In the meantime, any student choosing this option and transferring back to their school in Puerto Rico will not count in the denominator and/or adversely affect graduation rates." for Florida schools, Lyons told superintendents.
Up next:Pasco School Board candidate arrested for DUI
A makeover for St. Petersburg's Jordan Park housing complex kicks off at lastEarlier today• News
Florida's omicron deaths nearly double as infections keep fallingEarlier today• News


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Census shows young adults are being drawn to the city
This story is part of a series on the changing face of Philadelphia as reflected in the new 2010 census figures.
Heather McKay, 25, moved into Center City because she says she likes the "urban lifestyle." (JULIE SHAW / Daily News staff)Read more
by By JULIE SHAW, shawj@phillynews.com 215-854-2592
Seeking an "urban lifestyle," Heather McKay moved into Center City four years ago even though she works in Montgomery County.
"There's so much to do" in the city, she said, as she walked her black rat terrier, Clark, around Rittenhouse Square yesterday.
She lives near the park and particularly likes the city's nightlife - hanging out at Time restaurant and bar and the Continental Midtown, especially its rooftop.
McKay, 25, moved here from Blue Bell, where she grew up, and drives to her marketing job in Plymouth Meeting.
She is one of the 50,306 young adults, ages 20 to 34, who helped contribute to the city's population growth from 2000 to 2010, according to census data being released today, which show breakdowns of residents by age groups.
Last year, there were about 393,000 people ages 20 to 34 who lived in the city, accounting for 26 percent of its residents.
While the city grew by a mere 8,456 people, or 0.6 percent, much of the increase was attributed to these young professionals who live in Center City, South Philly east of Broad, and the Manayunk and Roxborough area, according to a Daily News analysis.
Adults ages 55 to 64 also boosted the city's population, with 35,592 more of them living here, particularly in the Northeast, West Mount Airy, Germantown and Center City, based on data released along state representative-district boundaries.
But a large decrease in the city's population was that of children ages 5 to 14, a group that saw a 43,370 decrease, suggesting that families with school-age kids moved out of the city for better opportunities.
Along those lines, the number of adults aged 35 to 54 declined by about 16,000 over the decade.
The growth in young professionals shows that the city has "retained more of our graduating seniors," said David Bartelt, a professor of geography and urban studies at Temple University, adding that the city has been strong in service-sector jobs, such as tourism and the restaurant business, and in creative endeavors, such as the arts and public relations.
As for why families with younger, school-age children declined, Bartelt said it could be because of a lack of employment opportunities in traditional job sectors, making people look elsewhere, even out of this region.
Gary Jastrzab, executive director of the City Planning Commission, said some families with school-age children may have moved out so their kids could attend suburban schools.
With the rise in people ages 55 to 64, Jastrzab said the new data back up anecdotes that have said empty-nesters in their peak earning years or entering their retirement period have been moving into the city "looking for more active lifestyles" or to be close to the arts.
He also noted that Philly has been attracting young adults because of its affordable housing, active nightlife and ease of getting around by public transportation, walking or biking.
Although some professionals 35 and older have moved out of the city, Anthony M. Santaniello moved back into the city in 2001. He had lost his job in New Haven, Conn., and really missed the city.
"I was longing for the little streets, little cobblestone alleys," said Santaniello, who had also previously lived in Chicago.
Santaniello, 39 and single, who works at the City Planning Commission, bought a house five years ago east of Broad Street, near Ritner, in South Philly. He takes the subway to work and likes to walk around the city.
Merritt Lentz, 34, also loves the convenience of the city. He moved to the Rittenhouse Square area from Wynnewood in 2007 to be in walking distance to his job at a law firm here.
He also enjoys being able to take the Broad Street Line to watch Phillies games, and likes Rittenhouse Square, where he was walking his chocolate Labrador retriever, Riley.
"It's nice to have all the green next to my house," he said.
By JULIE SHAW, shawj@phillynews.com 215-854-2592


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Paris in the springtime: the Jardin des Plantes
No city really multitasks like Paris, shorthand for romance, culture, fashion, gastronomy and the kind of street life you find on Robert Doisneau calendars. The £69 Eurostar return opens up a vista of civilised pleasures: the best cheese shops (Androuet), the loveliest perfumeries (Serge Lutens, Palais Royal), the best markets (Marché des Enfants Rouge), the prettiest dolls' house shop (Pain d'Epices), the most engaging museum (Jacquemart-André). Armed only with Patricia Wells's unsurpassed Food Lover's Guide to Paris, Inès de la Fresange's style guide, Parisian Chic, and the Penguin Map Guide or the little brown Paris version of the A-to-Z, you're on a roll.
Yes, I know London's meant to be where it's at when it comes to cultural dynamism and ethnic restaurants (though Paris has an interesting Japanese vibe just now), that many of Paris's finest are tax exiles in Britain, that the irresistible Left Bank cafés where smoking Gauloises was practically obligatory have been displaced by all-day Anglo-American eateries. I don't care. Paris may be less eccentric, more casual than it once was, but it's still where apparently unstrived-for elegance is the default mode, where you always greet the shop assistants, where the search for the finest éclair or the most fabulous nail varnish or the perfect colour hyacinths for a bouquet is taken quite seriously. Given the global character of our pleasures nowadays, it's interesting how Paris stands aloof. You can get Parisian brands in London: Maison du Chocolat truffles, Ladurée or Pierre Hermé macarons, Poilâne sourdough, even Maille boutique mustard and Frederic Malle scent. But just not in the same way. In Paris everyone's game is raised because people take trouble to seek out what's really good. Consumption is less gross there, not only in quantity. The regulations that meant, at least until recently, that a bakery would always be replaced by another bakery, that you couldn't shop everywhere on Sunday, and that Christmas sales began after Christmas, curbed and civilised consumer appetites in a way you don't get here.
Quite what you take from Paris, other than envy at the effortless chic (even the bloody dogs in handbags are stylish), depends on circumstances. It's not until you have children, for instance, that you realise it's a child-friendly city, assuming they aren't monsters. We stay at the Hyatt Madeleine (just up from Fauchon!) where they go out of their way to be nice to them, but in fact people are surprisingly kind to children all round. And may I just say that the Paris Ménagerie du Jardin des Plantes is way more charming than London Zoo.
Paris — well, central Paris (the periphery is another story) — is the perfect city, really. It does every scale well: the grand public spaces, like the Place de la Concorde, the small street markets, the intimate tea salons, the river scene, the little museums (Museum of Magic) and the big ones (Musée d'Orsay). And it's walkable. All I can say is, steer clear of the Eiffel Tower. It's so not worth it.
Seeing Paris through Impressionist eyes
Harry Mount
Saltburn-by-the-Sea is having its Goldilocks moment
Justin Marozzi
Tapestries are beautiful, romantic – and half the price of wallpaper
Constance Watson
Never mind the Northern Powerhouse – here comes the Oxford to Cambridge corridor
Hugh Pearman
Jacob Rees-Mogg has said the unsayable. Good for him


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251: Brother's Keeper
Whatever Happened To Baby Cain?
Jonathan Goldstein retells the story of Cain and Abel. Finally we get to hear Cain's side of things. (18 minutes)
More in Religion
651: If You Build It, Will They Come?
Act One: Come All Ye Faithless
Eric Mennel tells the story of one church planter, Watson Jones, who sets out on his mission to build a new church in a very challenging setting.
635: Chip in My Brain
Act One: Believing
A private basketball coach teaches a young student some things his parents don't agree with.
Act Two: Unbelieving
Cody's parents try to get him to unlearn some of what AJ taught him—and it's difficult.
More by Jonathan Goldstein
597: One Last Thing Before I Go
Act Two: Uncle's Keeper
Jonathan Goldstein tries to convince his uncle and his father to get into the same room and have a conversation for the first time in decades, before it's too late and one of them dies.
557: Birds & Bees
Act Three: About that Farm Upstate
While it's hard to explain to kids how babies come into the world, it might be harder to explain that people leave the world too — especially to a kid whose mom or dad or brother or sister has died.


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This Buccaneer Pirate Ship Must Maintain Even Keel
While the Bucs are off to their best start since 2005, it is important for the fans and team to maintain an even keel. There is reason for hope but also cause for concern.
By Gareth Rees Sep 21, 2010, 11:30am EDT
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TAMPA - There's no doubt that Bucs fans enjoyed the beat-down of the Panthers last Sunday and that the 2-0 start has lead to a renewed optimism throughout Tampa Bay. That is immediately evident by the fact that despite preseason media reports suggesting a season of TV blackouts, this week's contest against the Steelers at Raymond James Stadium should sell out. The media is paying attention again and suddenly sports talk radio remembered that Tampa has an NFL franchise. Winning can quickly cure all ills.
It is important however to remain focused and understand that while today we are undefeated that means little going forward. This team could still make a prophet out of Peter King and run off 14 straight losses so one must temper the excitement and turn to reason when analyzing these Tampa Bay Buccaneers.
Sure, some of you are going to dance and sing and let your friends know how great it is to be undefeated. You'll call your Dallas Cowboys fan buddy and ask him whats wrong with Romo and offer to trade him Freeman in jest. You reveled in the joy of seeing Brett Favre decompose on the field against Miami, knowing that Cadillac Williams' club is already two wins better than Adrian Peterson's club. You may even start telling everyone that you have a better record than Peyton and Brady, and inform them that you are tied for first place with the Super Bowl champion Saints.
You need to calm down.
The Bucs have two victories, a feat that took them fifteen weeks last season. That's great, but it should not be overlooked that the teams they have played so far are now a combined 0-4. In addition, both teams are already, in only Week 2, using their second string quarterback. The Browns are a mess, they are in the first year of a major rebuild and couldn't beat Kansas City in their home opener this week. Jake Delhomme and Matt Moore will never be mistaken for Aaron Rodgers or Drew Brees; Jimmy Clausen, in one drive in the fourth quarter completed more passes than Moore did the entire first three. These aren't exactly pillars of NFL success that have crumbled under the might of the power-house pewter pirate ship.
You are going to tell me that a win is a win, and in the NFL every win is sacred. You are going to tell me that the Bucs have nothing to apologize for and that they can only play the teams that they have been scheduled.I agree with you, and you are absolutely correct. But while there is many a reason to be excited about the best start in seven years, there are also causes for concern.
In addition to the mediocrity of the opponents, there's the Tampa Bay running game, or better put, the lack thereof. Cadillac Williams was once a surefire star running back in this league but two knee surgeries later it is clear that he is no longer an elite back. Through two games Caddy has carried the ball 49 times to the tune of only 126 yards. That's a paltry 2.6 yard per carry average. Against playoff caliber opponents and staunch passing defenses that simply wont get the job done. Expounding upon this issue is that the Bucs have had only two rushes of greater than 15 yards and one of those belongs to quarterback Josh Freeman. The offense is going to need to find some way to move the ball as they won't always be able to count on Freeman's feet and arm.
While the team has played well against mediocre opponents its first two games, the schedule upcoming is not as favorable. The next three matchups are all against playoff teams from a year ago, including the Super Bowl champion New Orleans Saints. The Pittsburgh Steelers come to town 2-0 despite being down to their third-string quarterback, led primarily by a suffocating defense that held the sensational Chris Johnson to 34 yards and forced seven turnovers last week in Tennessee. A trip to Cincinnati after the bye week, and hosting the Super Bowl champions in Week 6 will bring no relief and prove great challenges for a young Buccaneers defense that so far has bent but not broken.
Ultimately this season, like the future of this franchise, lies in Josh Freeman's hands. He was handpicked to be the face of the franchise for many years to come and his maturation is going to be the key that leads this Bucs team from farce to fantasy. If he can continue to get outstanding help from a young, energetic defense and if his bond with rookie Mike Williams continues to grow then this team can surprise a lot of people... Peter King especially.
So today, enjoy this team and its record because getting out of bed is easier, the air is cooler, the sun is brighter and birds sing sweeter when our Tampa Bay Buccaneers are undefeated. Wear your Bucs shirt with pride, go out and get yourself a new Josh Freeman jersey. Get some tickets to the game and fill up that stadium. But know that there will be bumps in the road, and there will be growing pains with such a young group. The fans, as well as this team, must maintain an even keel as the pirate ship will run into choppy waters along this journey.
No matter what may happen the rest of this season, it sure is refreshing to know this team is finally heading in the right direction.


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Dastan's Enchanted World
Nishat Zaidi
THE BEGUM AND THE DASTAN by Tarana Husain Khan Tranquebar, 2020, 271 pp., 499.00
Urdu Dastan refers to an extant mode of storytelling where popular fantasies, literary tropes and a hint of history is melded to produce utterly entertaining and absorbing stories. Often about legendary characters, the charm of the dastan rests on its flamboyance, verbal excesses and a fine entanglement of the ordinary and the extraordinary, of the mundane and the marvellous.
Tarana Husain Khan, in this thoroughly readable and vastly riveting novel, tells us a nineteenth century Dastan through the aperture of a twenty-first century family lore, where a quintessential tale-telling, full-of-stories 'Dadi' narrates the story of her aristocratic grandmother to her granddaughter, Ameera. Ameera's life forms a gossamer-thin frame-story woven with textures of the ordinary and the banal, through which we are propelled into an extraordinary, suspense-thrill-filled life of Feroza Begum, one of the many wives of Nawab Shams Khan of Sherpur circa 1897.
Ameera is a young girl, trapped in the confines of her house due to a series of woes, such as feuding parents, decay of family wealth, partiality of parents towards her brother, non-payment of school fee, issues of finance crunch, an imaginary boyfriend and so on. Though diaphanous in its detailing and impact, this frame story is significant for it provides us with a vantage point to compare the oppressive life of the nineteenth-century harem with modern homes. Sensing Ameera's restlessness, the grandmother narrates Feroza Begum's tale as a dars or 'cautionary tale' to warn her about the consequences of recklessness in women.
The narrative tour de force, however, is the hauntingly beautiful, gripping, grim and heartbreaking narrative of Feroza Begum. The beautiful blue-eyed daughter of Miya Jan Khan, a wealthy Rohilla Pathan, Feroza Begum is a fiercely independent, recklessly fearless, willful young girl who defies norms and questions time-honoured social structures. Unlike Ameera of the frame story, her father loves to indulge her. She is happily married to Murtaza and expecting her first child when the story begins. Feroza's wilfulness is conveyed to the readers through her sartorial choices that defy norms of sharifzadi, as she insists on wearing a Chudidar and a transparent kurta, usually worn by courtesans, instead of a gharara adorned by the women of ashraf families. She further defies her family and the wishes of her father, when she decides to attend the sawani celebrations at Nawab Shams Ali Khan's Benazir Palace. The Nawab being a known Aiyyash, she seals her own fate by her actions.
Predictably, Feroza is kidnapped and detained in the Nawab's crowded harem, which houses his many Nikah wives, his Mutah wives and the many concubines who are holed up in their tiny hovels under despicable conditions. Under the duress of the Nawab, her husband is forced to divorce her, and her family to disown her. Not left with many choices, Feroza is compelled to marry the Nawab, and to come to terms with the glamour and the squalor of the harem. Slowly, she comes to enjoy her privileged position in the harem, and to retain it she indulges in artifices in her sexual encounters with the Nawab, in which she secretly rejoices, and resists when it is taken away from her. Through the Nawab, the novel attempts a commentary on the despotic rulers who, on account of their support to the British during the 1857 Revolt (in lieu of which the British remained silent spectators to their excesses) had become untamed autocrats given to debauchery.
Khan, who is also a cultural historian, and has written essays about the culinary history of the Princely State of Rampur, is at her creative best when she lunges into the complex web of the Nawab's harem at Benazir Palace and the murkiness that cloaks the lives of women trapped in the zenana. The relationship among the wives, their dreams and desires, the tortures they are subjected to when they rebel (such as being subjected to the life of Kawwa Hakni or a scarecrow), the role of servants, the luxury and the destitution of women, are all etched out in graphic prose, leaving a powerful impression on the minds of the readers. That the apparent pomp and glamour of Princely courts with their aura of ceaseless festivities, could dissemble so much of brutality, comes as a shock to the sensibilities of modern readers.
If the frame story of Ameera lends Feroza Begum's story an anchorage to the present reality, there is yet another narrative frame through which Feroza Begum's story is harnessed to an allegorical frame. Through Kallan Mirza, a seasoned dastango, we are taken outside the precincts of the zenana, and the courtly life of Benazir Manzil, to the city chowk, where humble folks gather to listen to him spin a powerfully evocative tale of a despotic sorcerer, Tarek Jaan, and his grand illusory city, the Tilism-e-Azam. Kallan, an opium addict, uses elements from the Tilism-e-Hoshruba to pull his audience into the vortex of his fantastical tale where the boundaries of fantasy and reality are blurred. With women locked up in dark basements, Tareek Jaan and his city epitomize the tyrannical rule of Nawab Shams Ali Khan, his moral turpitude and his oppressed city. Kallan's tale becomes a commentary on his own contemporary society.
The author, in her interviews, has termed the novel a historical fiction. This authorial intent is further impressed by the foregrounding of chronology and location in the novel. Having said this, it is one of the salient features of the Dastan that historical characters gain what Hamid Dabashi has called 'fictive and phantasmagoric dimensions'. By the same token, though the novel may have strong historical elements, its appeal lies neither so much in the historical insights we glean from it, nor in reading it as a tale of feminist resistance. Such provocations neither add to nor diminish the appeal of the novel.
Flamboyance and extravagance are two key stylistic features of the Dastan genre of narratives. Wary of the sensibilities of modern Anglophone readers, Tarana Husain Khan has dispensed with the extravagance. She has also desisted from the ideological frame of Dastan's enchanted world, where there is a clear line of demarcation between 'virtue' and 'vice' underlying the enchantment and sorcery-driven narrative patterns. But she has retained the rhythmic, mellifluous and near hypnotic quality of prose. Khan's smooth grafting of the flamboyance of Urdu Dastan to the Anglophone narrative lends Feroza Begum's tale a compelling power. It is an exquisitely rendered, splendid story which you can read at leisure. The book, indeed, is an unputdownable page-turner.
Nishat Zaidi is Professor at the Department of English, Jamia Millia Islamia. Her publications include her monograph Makers of Literature: Agha Shahid Ali (Sahitya Akademi), Day and Dastan (translation of Intizar Husain's novellas). Her forthcoming book is Karbala: A Historical Play by Premchand (OUP).


While much better than Jack the Giant Killer, this Asylum movie is definitely still terrible. Though, you can't help but be impressed with the studio's mission; To pump out cheap, awful movies and make money with quantity over quality. Maybe it's time we put the microphone down and pick up a camera to show Hollywood how its done. The world needs to see Gordonman v. Geoffman: Dawn of Podcast. Also we talk about Room and Whiskey Tango Foxtrot. Next week, we'll be watching The Legend of Sarila.


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« "Internet Paradis Perdut" debat a l'Alternativa
Lecture at the Open Fields Conference 2017: Virtualities and Realities »
Cultural Innovation International Prize _ PostDigital Strategies for the Anthropocene
Gallery, News, Projects
PostDigital Strategies for the Anthropocene will be presented at the
Climate, culture, change
Activity programme and prize award presentation ceremony of the 2nd Cultural Innovation International Prize 2016-2017
to be held the 20 – 21 June 2017 at the CCCB
"Postdigital Strategies for the Anthropocene" is a project that applies the concept of Postdigital Strategies* to the understanding of the Anthropocene. Specifically, it proposes the design of actions to involve audiences with climate change and turn them into active and empowered agents. The aim of the project is to propitiate a posthumanist vision of the Anthropocene and, at the same time, to foster new relationships between institutions, audiences and the technosocial milieu. This new relationship is meant to shift the Cultural Institution into a Space of Transformation*. This is a space of encounter for collectives of human and non-human agents as well as the controversies emerging from the concretization of the concept (Anthropocene). The institution becomes at the same time an agent actively involved in the social and environmental construction that characterizes this concept. The audience becomes an active agent, empowered by the acquisition of an operative knowledge emerging from the appropriation of the technological milieu for the development of local actions aimed at the improvement of the ecosystem.
We are increasingly aware of the role that data processing plays in the understanding and management of our environment. Computing technology has become ubiquitous and embedded in daily life. In this way, it is producing new possibilities for the design and control of our environment. Our milieu is becoming technological and this arises expectations, fears and controversies. On one hand, there is a techno-utopic confidence in the computing capacities of an almost omniscient machine, constituted by networked sensors and processors, believed to be able to solve the pressing problems that can bring our civilization to collapse. On the other hand, there are growing fears about the surveillance capabilities of a system in which we are inadvertently integrated and reduced to a set of computable features, potentially becoming passive and manipulated by the milieu itself. Numerous controversies spawn from the tensions between the continuous need for innovation and production that characterize our economic system against the need to modify our behaviour in order to develop more sustainable ways of life. In front of this situation, the Postdigital Strategies stand as a proposal to appropriate technology, inspired by artistic practices, in a way where the users will intervene in the functioning of these technologies by acquiring an operative knowledge. From these actions, it will be possible to unveil the complex ecological meshwork we are involved in. Through this process of involvement and discovery, the audience becomes an agent able to start actions that eventually could be amplified towards a significant environmental change.
These strategies, result in the development of projects related to citizen science. Projects such as http://www.mosquitoalert.com/en/, http://www.fenodato.net/, http://natusfera.gbif.es/, and others involve citizens beyond mere data collection and into the open fabrication of sensing devices and in producing awareness about the material conditions in which data are constructed. However, there are comparatively few projects that involve audiences in data use and interpretation. Our proposal is aimed to provide the audiences with tools that empower them in data collection, data interpretation and in the critical and operative use of the epistemological models resulting from their involvement. Whit this goal in mind, we propose the creation of a platform and the realization of a series of workshops to be held concurrently with the exhibition "After the end of the world". From these activities there will emerge new forms to understanding, narrating, and acting in this new geological era in which we are all immersed since participants will be engaged in the processes that they devise and hence can also change.
The term Anthropocene was proposed in 2000 by Nobel laureate Paul Crutzen and Eugene Stoermer, in the article Have we entered the Anthropocene? Here, they defined a new geological era in which humankind's activities had increased its capacity to transform the environment to the point of becoming a new geological force, and altered to the need to harness research and engineering to create a sustainable global environment.
The Anthropocene situates us in a world where the natural environment has been modified by human technological capacity, with practices such as extensive agriculture, industrialisation, colonialism, the atomic age, urbanisation and the subsequent increase in human population (which grew from one to seven million between 1804 and 2011), changing the composition of the soil and the atmosphere, causing the redistribution of some plant and animal species, and the mass extinction of others. These changes are aproaching limits that threaten the continuity of our ecosystem. One of these limits is climate change. The concentration of carbon dioxide in the atmosphere has increased from 280 parts per milion in the industrial era to 400 ppm in 2014, the recognised limit of acceptable climate risk. This increase is giving rise to consequences such as an accelerated melting of the ice sheets in the Antartic, rising sea levels, and the disappearance of coral reefs. Studyng and addressing this complex situation with which the Anthropocene present us calls for more than a single scientific discipline, and the involvement of all human and non-human agents.
Since its advent, "Anthropocene" has been a scientific term, with a comission to examine the Anthropocene that studies the uniform deposit of artificial materials on the earth's crust to propose recognition of this geological era to the International Commission on Stratigraphy. But it is also a political term, highlighting the way in which the administration of resources linked to capitalism is leading us inevitably to the collapse of our civilisation. It also is a philosophical term, which has become part of the thinking of authors such as Braidoti, Stiegler and McKenzie Wark, who move between the critique of the current social system and the proposal of a post-humanist vision that can throw light on this complex situation, at the same time alerting us about the problems of excessive confidence in constructivism.
Although there are various diverging proposals when it comes to defining the concept of the Anthropocene, Stiegler dates its emergence to the Industrial Revolution. The Industrial era saw a new organology – a new relation between human beings and the technolgical system based on automation.
The appearance of this new technical system produced an epistemic crisis, undermining the traditional distinction between natura and culture. Nature was conceived as a given, the object of contemplation, while technological activity was regarded as something contingent an outside rational thought. Automation has produced non-human agents capable of forming a system and transforming living conditions, at the same time showing the world not as something in equilibrium but as a result of thermodynamic processes. The world emerged as neguentropy, the result of processes beyond our control and our will.
This system evolved towards the constitution of global capitalism and the algorithmic control tha characterises our present day environment. The automation of calculation processes has led to the development of information science and ubiquitous computing, a system based on the ability to abstract any entity in the environment to computable data that has increased its processing capacity and connectivity to the point of becoming embedded in the physical environment, modifying not only how we perceibe it and communicate in it, but also its confrmation and administration, increasingly carried out by artificial intelligent autnomous systems. Stiegler attributes to this situation, which I characterize as Postdigital, the destruction of the social environment, and the absence of rituals and shared dreams that allow us to project human thought into the future, allowing us to question the current situation and start producing new things. A world where the technological system becomes autonomous and self-producing, apart from our knowledge and consciousness, at the same time as it destroys the biosphere.
Postdigital Strategies connect with Stiegler's proposal of a productive intervention. The emergence of a technical mentality, defined by Simondon as knowledge of the emerging system in use, allowing the appropriation of the apparatus of the present technological system towards speculative experimentation and the creation of novelty.
In this way. Postdigital Strategies approach the concept of hypermaterialisation proposed by Stiegler- A form of daily reality in which material applications transform everything into information subjected to contiuous transformation. Or to the concept, closer to artistic practice of Neomateriality, proposed by Christiane Paul. An objectology that incorporates connected digital technologies and subsumes processes to reveal the encoding processes, the data incorporated from humans and the environment, and show how digital processes see our world.
While approaching practices related to software studies and media archeology, the Pstdigital Strategies aim to reveal the form and functioning of the digital apparatus shaping our environment. Postdigital Strategies are activities that involve collectives in physical experimentation with new technologies for creative purposes. Activities that see the emergence of an operative knoeledge that allow us to understand the capacity foranticipation and action of ubiquitous computing, at the same time producing things that arecapable of interrupting the autopoietic functioning of the system. Activities that allow the people in question to become agents involved in the production of new things and the speculation about new forms of life.
These strategies are defined as ativities that experiment with the material components of today's technological system, whit the following aims:
To criticise and embody the information processes and epistemological models that are mediating our understanding of the world. From the macroscope to the collaborative production of locally implemented and inclusive data diagrams.
To promote the creation of collectives of human and non-human that propitiates the inclusion of all agents and the understanding of the ecosystem we are involved.
The speculation about new possibilities, objects and processes, locally produced, which can be maximized towards a significant change in the biosphere.
Today we are seing the promotion of institutional websites and projects to showcase the global changes in our ecological system, visualizations sucha as Cameron Beccario's "Earth Windmap" that enable us to follow climatology in real time all over the planet, or "Migration in Motion" by Justine E. Hausheer, which shows the movement across the globe of various animal species due to climate change, also the design of platforms where citizens can upload observations to databases for producing new visualizations.
But these models remain macrosystems, operating out of reach of our actions and daily lives, something that happens in a different sphere and to be analized by experts, where citizens are mere observers, ignorant of the role they play in this change and its conceptualization. This project aims to make the cultural institution a welcoming space where citizens can become active agents involved not just in mitigating climate change but also in understanding and conceptulizing Anthropocene.
Project developed by Sandra Álvaro.
Workshops by: Pilar Rosado, Natalie Jeremijenko, Sandra Álvaro and Ramon Sangüesa
* Concepts developed in the Ph.D thesis: "Postdigital City. Aesthetics and Politics in the Space of Embodied Virtuality": Sandra Álvaro, Universitat Autónoma de Barcelona 2016. ISBN 9788449068775
PostDigital Strategies for the Anthropocene is one of the teen finalists projects at the Cultural Innovation International Prize held at CCCB Barcelona
The Cultural Innovation International Prize is a biennial competition organised by the Centre of Contemporary Culture of Barcelona (CCCB) with the aim of incentivising projects which explore possible cultural scenarios for the coming years. It functions as a new space for creation, production and diffusion of projects concerned with developing imaginative solutions for the cultural challenges of the twenty-first century.
The second edition of the Cultural Innovation International Prize focuses on the subject of Climate hange.
How can culture defy climate change? The second edition of the Cultural Innovation International Prize encourages projects that offer imaginative and effective solutions to one of the biggest global problems of the 21st century. The winning proposal will be featured in the activities included in an exhibition on the subject at the CCCB
About the shortlisted Proposals
Program of the event See the program of the event
Tags: Anthropocene, Climate Change, Culture Analytics, Data Visualization, PostDigital, PostDigital Strategies


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Q: Python WAV "TypeError: data type not understood" error I've had a problem reading a .wav file using Python. I want to read the amplitude and sampling rate of the file.
I tried reading the file using the following code:
import os
folder = os.getcwd() + '\\WAV'
file_name = 'Guitar.ff.sul_E.C5Bb5'
path = folder + '\\' + file_name + '.wav'
rate,data=read(path)

Before the above code, I imported the read function from the scipy library as follows:

from scipy.io.wavfile import read,write

And from numpy I imported:

from numpy import linspace,sin,pi,int16

I received the error "TypeError: data type not understood".
The code worked perfectly for a different .wav file, and I'd like to know how (if it's possible) I can change the code to read this one, or if I must change the .wav file before I can read it.
Below are the properties of the files:

*

*File: Guitar.ff.sul_E.C5Bb5.wav

*

*Size: 38.87 MB

*Length: 1 minute 10 seconds

*Sample Rate: 96 KHz

*Sample Size: 24 bit

*Bit Rate: 4,608 kbps

*Channels: tried 1 and 2

*File: 440hzAtone.wav

*

*Size: 173 KB

*Length : 2 seconds

*Sample Rate: 44.1 KHz

*Sample Size: 16 bit

*Bit Rate: 705 kbps

*Channels: 1

The first file didn't work and the second file did.
I got the exact same error for 1 and 2 channels.
Changing the file name so that it doesn't have dots doesn't matter. It seems to reach the file either way but not be able to read it.
Edit:
After changing the bit depth from 24 to 16 the problem is gone. Thank you Warren Weckesser for the comment.

A: Unfortunately, scipy's wavfile reader can't read 24 bit files: scipy issue 1930 on github
Check out https://pypi.python.org/pypi/wavio or get the source at https://github.com/WarrenWeckesser/wavio

redpajama_set_name: RedPajamaStackExchange


text:
100-Year Starship Project Forges Ahead With First Round of Funding
An ambitious effort for an interstellar travel planning organization officially kicked off this week, after DARPA awarded $500,000 to form the 100-Year Starship initiative. Former astronaut Mae Jemison, whose proposal was selected earlier this year, will lead the new independent organization. The goal is to ensure that the capability for human interstellar travel exists within the next 100 years.
It may not look like the starship Enterprise, but a real interstellar vessel is possible within that timeframe, Jemison said. "Yes, it can be done. Our current technology arc is sufficient," she said in a statement.
In its first year, the organization will seek new investors and develop new ideas for interstellar exploration, the new 100YSS website says. A public symposium is planned for September in Houston, where anyone from engineers to philosophers will be able to present papers and host talks about the challenges of such a project. The 100-Year Starship is not necessarily a ship per se, but an organization that can last 100 years and potentially carry out the vision of a real starship. It will look for input from scientists, engineers, doctors, sociologists, writers (!), ethicists and public policy experts.
The 100-Year Starship project also has a new scientific research partner called The Way, an awesomely named spinoff that will focus on "speculative, long-term science and technology," according to the project. We can't wait to see what they come up with.
[via EE Times]


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2019 Med Device Trends to Watch For: Regulatory Changes
14 February, 2019 by Cindy Fazzi, Staff Writer, MasterControl
For the medtech industry, 2019 is going to be marked by a slew of regulatory changes, beginning with Canada's requirement of Medical Device Single Audit Program (MDSAP), which took effect on Jan. 1. Companies that have been procrastinating are expected to be hit hard.
The deadlines for transitioning to ISO 13485:2016 and the European Union's (EU) Medical Device Regulation (MDR) are also looming. The shifting regulatory landscape is the No. 1 development to watch for this year, according to a new white paper, "Top 5 Medical Device Industry Trends in 2019."
Four medical device experts shared their insights and offered some advice to medtech professionals in the white paper. Two out of the top five trends they identified were related to regulations and standards.
Canada's #MDSAP requirement for #meddevice firms is now in effect. Are you ready for other fast-approaching regulatory changes? @MCMasterControl http://bit.ly/2DvY5x5
Canada and MDSAP
MDSAP has replaced the Canadian Medical Devices Conformity Assessment System (CMDCAS). Class II, III and IV medical device manufacturers are now required to assess their quality management systems under MDSAP in order to sell their devices in Canada.
The program aims to harmonize standards and facilitate audits for manufacturers that sell their devices in Australia, Brazil, Canada, Japan, and the United States. Of those countries, only Canada mandates the program. The U.S. Food and Drug Administration (FDA) will accept MDSAP audit reports as a substitute to routine FDA inspections.
Health Canada, the country's national public health authority, acknowledged that its MDSAP requirement could mean a financial burden for some medical device firms. MDSAP audits are expected to cost more than ISO audits and take longer to conduct.
"It is anticipated that some manufacturers, instead of conforming to the new MDSAP requirements, may be cancelling their medical device licenses and discontinuing the sale of their products," the agency said. "Health care professionals should discuss with their suppliers if they have any concerns regarding the ongoing availability of their current products." (1)
Other Looming Changes
The deadline for transitioning to ISO 13485:2016 is close on the heels of Canada's new requirement. To maintain ISO 13485 certification, device manufacturers must meet the requirements under the latest version of the standard by March 31, 2019.
Top 5 Medical Device Industry Trends in 2019
The revised standard emphasizes risk-based approach to quality management throughout the product life cycle. Companies that have not yet transitioned are likely to face a steep uphill climb. Conducting a gap analysis and then making the necessary changes to their quality systems will take months, not to mention scheduling an actual audit and training personnel on the changes. All of this requires ample time and effort.
This is also the last year for companies to transition to the European Union's Medical Device Regulation (MDR). "European quality assurance and regulatory affairs personnel seem to be overwhelmed by preparations for the new MDR. This realization has not quite hit American companies," said Rob Packard, a consultant specializing in 510(k) submissions and helping startup medical device companies address quality and regulatory requirements (2).
Alex Butler, manager of medical device solutions at MasterControl, agreed that the MDR will have a huge impact. He said device firms that want to stay in the European market need to invest the time and manpower to evaluate their new requirements under the new regulation. "MDR is the perfect storm and it's coming," he said (3).
Faster Regulatory Pace
Device experts anticipate that as part of an evolving regulatory landscape, the pace of regulatory change will increase even more. In the white paper mentioned above, faster regulatory pace is ranked No. 4 out of the top five trends to watch for.
If you think there were too many new #FDA guidances for #meddevice firms last year, brace for more of the same this year, says @MCMasterControl http://bit.ly/2DvY5x5
"In fiscal year 2018, the FDA had planned to release 20 new guidances, but in reality, it issued 65! For fiscal year 2019, the FDA's agenda includes another 27 new guidances," said Michelle Lott, principal and founder of Lean RAQA, a regulatory and quality system solutions company. "And that's not to mention the fast-approaching MDR implementation date in May 2020. (4)"
Christopher Devine, Ph.D., president of Devine Guidance International and a MedTech Intelligence columnist noted the urgency of new regulations. "From a regulatory standpoint, if your organization has not started migration to the EU MDR, there's no time like the present to begin that journey. What was considered 'optional' under the old regulation will become mandated," he said (5).
Regulatory agencies and notification bodies worldwide, just like regulatory teams in device firms, are struggling to address the changes, which are happening so fast.
"You can't guarantee that your released product will not experience a hiccup in the next few years," said Butler. He recommended educating executives on the burdens faced by regulatory teams under the new regulations.
(1) Health Product InfoWatch, published by Health Canada, Sept. 27, 2018.
(2) Rob Packard is the president of Medical Device Academy, Inc. He has 25 years of experience in the medical device, pharmaceutical and biotechnology industries. He has served in senior management positions at several medical device companies, including as president and CEO of a laparoscopic imaging company. His quality management system expertise covers all aspects of developing, training, implementing and maintaining ISO 13485 and ISO 14971 certification.
(3) Alex Butler, manager of medical device solutions at MasterControl, oversees development and continuous improvement initiatives for several MasterControl core products, including MasterControl Regulatory Excellence. He has an extensive background in medical device technology and innovation, with over eight years devoted to product development, strategic planning, quality assurance and process improvement. Prior to joining MasterControl, he served as a product development manager for Opal Orthodontics, where he was directly involved in the development, quality and compliance, risk management, registrations, and launch of several Class II medical devices.
(4) Michelle Lott is the principal and founder of Lean RAQA, a regulatory and quality system solutions company. She has nearly 20 years of health care product experience, including holding executive roles for international regulatory and quality operations. She's currently serving on the FDA's Device Good Manufacturing Practices Advisory Committee as an industry representative.
(5) Christopher Devine, Ph.D., president of Devine Guidance International, has 32 years of experience in quality assurance, regulatory compliance and program management. His consulting firm specializes in providing solutions for regulatory compliance, quality, supplier management and supply-chain issues facing the medical device industry. He's a senior member of the American Society for Quality (ASQ) and a member of the Regulatory Affairs Professionals Society (RAPS) and Project Management Institute. Check out his MedTech Intelligence column
Cindy Fazzi writes about the life science industry and other regulated environments for MasterControl. She has worked as a journalist in three countries. Her two decades of experience as a news reporter, writer, and editor includes working for the Associated Press in Ohio and New York City. She has a master's degree in journalism from Ohio State University.
FDA's Plan to Replace QSR With ISO 13485: Pros and Cons
Leveraging the Value of Quality in Your Business Through ISO
Regulatory Barriers to Innovation for Startups
The FDA Mulls Proposed Ratings to Measure Drugmakers' Manufacturing Quality
Quality Assurance and Quality Control: What's the Difference When It Comes to Managing Quality?
Advancing the Case for Quality in Medical Device Manufacturing
Surge of Data Integrity Violations Irritating the FDA
Modernizing the FDA's 510(k) Review Process: Pros, Cons and the Twilight Zone, Part 3
De Novo Becoming Faster and Easier Pathway to Market
Medical Device Regulation (MDR)
The Standards Harmonization Process and 5 Tips to Manage It With EU MDR
Q&A: Device Manufacturers' FAQs on the EU's Medical Device Regulation (MDR)
Uncertainty Regarding EU MDR Underscores Importance of Certification Preparation
Christmas Comes Early to Medtech: U.S. Repeals Device Excise Tax
To Pre-Sub or Not to Pre-Sub? Weighing the Value of the FDA's Pre-Submission Program
Innovation and Compliance Harmonize Perfectly at Cochlear
Why MDSAP Opens a World of Opportunity for Med Devices
Building an Effective Global Regulatory Strategy for Medical Devices
Top Regulatory Trends Affecting Med Dev in Asia-Pacific Moving into 2019


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text:
Welcome to Ayodhya
Roadtrip From Lucknow Under Rs 4000 by car
Ayodhya also known as Saket, is an ancient city of India, believed to be the birthplace of Rama and setting of the epic Ramayana. Ayodhya used to be the capital of the ancient Kosala Kingdom.
According to one derivation, "Ayodhya" is said to derive from the name of King "Ayudh", mentioned in Hindu scriptures as a forefather of Lord Rama
Owing to the belief as the birthplace of Rama, Ayodhya has been regarded as one of the seven most important pilgrimage sites (Saptapuri) for Hindus. It is believed that the birthplace of Rama was marked by a temple, which was demolished by the orders of the Mughal emperor Babur and a mosque erected in its place.
Ayodhya is on the right bank of the river Sarayu, 8km from Faizabad. This town is closely associated with Rama, seventh incarnation of Vishnu. According to the Ramayana, the city is 9,000 years old and was founded by Manu, the first man in the Vedas, and law-giver of the Hindus. Other sources hold that it was founded by its namesake, King Ayudh.
Attraction in Ayodhya
Janki Mahal
Laxman Quila
Ram ki Paidi Ghat
State: Uttar Pradesh
Distance From Lucknow: 136 Km.
Weather: HUMID AND PARTLY CLOUDY THROUGHOUT THE DAY.
Road Trip : New Delhi to Unchagaon
Guru Purnima: Travel is the best teacher.
Discover Orchha and Jhansi with JustWravel
Top 7 Weekend Getaways From Delhi You Just Can't Miss
7 Amazing Weekend Trips You Can Take From Agra


hi everybody. my grandad served on ML 269 his name is john haddon was just wondering if anybody has any info or can tell me some good books or websites to look on.
Welcome to the forum. I have a small amount of information on ML 269, though Mr Brian Holmes who holds a very good collection of information on most Coastal Forces boats may be able to supply you with more information once he sees your post.
Briefly then: ML 269 was a Fairmile B Motor Launch, constructed by William Weatherhead of Cockenzie, UK on 28.07.1941. It was passed to the Free French (as the Beniquet?) between April 1942 and August 1942 and then transferred to Burma under the charge of the RNVR in October 1945 before being put up for disposal in December 1945.
I am a supporting member of the Fairmile Association here in Australia and one of our members who lives in NSW served on ML(GB) 269 while in Burma in the Arakan area. I've just had a look in the book "The 13th & 14th Fairmile Flotillas in Burma" which mentions 269 quite a bit and has a crew photo which includes your grandad and Ken Joyce the chap I mentioned.
Send me an e-mail to -- debrogerp@hotmail.com and I will pass it on. I've just spoken to Ken, a lovely Scottish gentleman and he remembers John very well, is he still with us? Ken says he would be very happy to hear from you.
My wife's grandfather (Gilbert aka Jim Christie) served on the 269 in Burma and only today I was going through his pictures with him. SkipHaddon, would your grandad have been known as ginger Haddon? If so Drop me an email on thayes636@live.com as I have some great pics for you.
Roger, would Ken mind if I shared some of this info with him? I know it's a long while since the original post but thought you may find this interesting.
Thanks for this, fantastic info that is already being discussed. The photo of the crew shows my wife's grandfather in the 2nd row 1st on the left.
I've just forwarded this thread onto Ken Joyce and I'm positive he'll get in touch if he hasn't already done so. Nice photo's of '269' as well, one day I plan to do a model of '269'. All the models I've done/doing of Fairmile B's have all been quite different, especially weapons fits and colour schemes, all very interesting.
Ken and I have exchanged emails already, much appreciated.
ML 269 survivors have gone from three, Alan Penny, Eddie Perry and me, to five with the good news that Ginger Haddon and JIm Christie are still wih us. Eddie Perry had traced seven of us and we had all met either in Preston, Plymouth and South Wales. Harley, Spiers, John and Earnshaw had died.
Welcome aboard, we hope that you enjoy this Forum.
If you have any further info - photo's or reminisces - please feel free to share them with us.
I found this site following some research by my brother Ian in to our grandfathers time in WW2. First Lieutenant Clifford Lazenby served on ML 269 between August 1943 and February 1944. He briefly commanded ML 571 before returning to ML269 in October 1944 until he left in January 1945. Unfortunately information is sparse, as he never said a great deal. We understand that ML 269 was severely shot up in one engagement and he subsequently suffered with shell shock. If anybody can shed any light on his time we would be very grateful.
He joined the RNVR as an Ordinary Seaman and served on motor gun boats operating the Oerlikon cannon. He narrowly avoiding injury when they engaged with a German E Boat. He was subsequently selected for officer training and went on to serve on ML 269 & 571.
He had a long life and was well respected by family and friends. As a family we are proud to have known and loved him. Thank you grandad, and thank you to all his fellow servicemen.
If any of you are looking for a good read we can recommend The War Of The Gun Boats by Bryan Cooper.
For you for your enquiry, and welcome to the forum.
Do you know if the injury your grandfather suffered was during the period the boat spent out in Burma, as detailed in this edition of the Coastal Forces Heritage Newsletter: Issue 14, May 2014: White Ensign Flown by ML 269 During the Last Action by Coastal Forces in World War II, or did this happen earlier during the war? If your grandfather was out in Burma with the boat then you might try sending another of our correspondents, Ken Joyce, a former member of the boat's crew a Private Message using the forum's system. Just give us a shout if you need help in sending one.
Hello Mark, the Admin post has just got in before I could send a reply to you. I am sorry to tell you that Lt Lazenby was not on ML 269 between us leaving Milford Haven in October 1944, heading to Burma where our boat was turned over to the Burma Navy in October 1945. You will still have more research ahead of you to cover that period.
ML 269 could well have been in actions before this time but of course I only know that we were was involved in two gun actions in Burma. In the action at Kokowa we received a direct hit on the 6 Pounder Gun Shield that you could put your fist through but maybe because it was in line with the pedestal none of us were hit, thanks be --- At the action near to Yandoon we were hit by only one mortar shell that resulted in Ronnie Clare being seriously wounded below. In both these actions there were casualties to 13th Flotilla crew. I only have details of ML 904 where two fellows were wounded and BIll McNemany killed.
I sometimes wonder if McNemany's death on 16th May 1945 is recorded in our records ? His passing is shown on the Portsmouth Memorial.
A/B W. McNemeny's death is recorded in our database also if you make your selection by Casualties - Unit - ML - 904. Note the slight difference in the spelling.
I picked up your messages because I am researching the Arakan Campaign. I am working with some guys from N.Z and a veteran who was a Captain on a Fairmile B. I am also working with a veteran who served on ML 194. After D-Day (Omaha Beach) ML 194 was modified and set off on a journey to Singapore to assist in the surrender of the Japanese. It's a fascinating story.
I thought you would like to learn of our project restoring a Farimile B - RML 526. The current First Sea Lord, Admiral Sir George Zambellas is our senior patron along with the grandchildren of Sir Noel Macklin, designer and founder of the Fairmile company.
or feel free to get in touch via this forum.
There is to be a Crowd Fund appeal late March where there are some very interesting 'rewards' for donations made. This may also be of interest to you.
Just posted on your FB page, caught by chance your latest news on 526 there, which is great of course, to see another of our surviving CF craft going to be restored, with recent re-launch of hull of MTB 219, along with as ever MTB 102, HDM Medusa, MGB 81 won't list them all! but no dis-respect intended, my hat if I wore one, would and is off, I can only manage arm chair support, time taken with a non CF but in my humble opinion, great vessel in Paddle Steamer Medway Queen...all the best.
In the midst of doing a family tree and I've just discovered that my grandfather was seconded to the ML269 on D-Day as a navigator for the event itself. He had previously been an Observer in the Fleet Air Arm (so why he was sent to the ML was beyond him). He remained on the ML269 until August when the boat went for refit - possibly before being sent to Burma it seems.
He passed away in 1985 but had the foresight to record his thoughts of the landings, of which a small portion was posted on the BBC http://www.bbc.co.uk/history/ww2peoples ... 3944.shtml recently.
Does anyone happen to have any information or even photos of the crew around early 1944 before the landings?
Since my original post in 2010 I sadly forgot about this post until now.
I'd like to thank everyone for the information regarding ML 269 and my grandad ginger Haddon (john Haddon).
Unfortunately he passed away a couple of weeks ago at the good age of 92. I recall with fond memories all the times he would point to the picture of ML 269 he had on his living room wall and tell me stories about his time serving during the war.
Just wanted to record that my wifes father is Henry (Harry) Wilson, he is now 95 and a survivor of ML296 deployed in Burma. Ive found the posts very interesting as i am in the process of obtaining Harrys records during the war. Ive briefly made him aware of the posts and Im now looking forward to being able to talk with him with the knowledge you have all posted.
Harry is in the photo previously posted front row 1st on the left (we also have this photo) and his signature is on the other photo.
Im happy to ask any questions anyone may have and relay any information that may come from our conversations.
Im also wondering who the survivors are now and whether they are in contact?
He was also on HMS Cowdray & HMS Thyme during WW2.
Hi David. It's good to hear that Harry is still with you all at the age of 95. We lost my grandad John Haddon (ginger Haddon) in September 2017 he passed away peacefully in his sleep at 92yrs old. We all still miss him greatly but have a lifetime of amazing memories. We owe so much to their generation. If Harry has any stories about my grandad or ML269 that he would be happy to share I would love to hear them.


No game key!!!! Please help!!!!
I had an issue buying the two key pack. I didn't received my second key ... Where can I find it ?
@NaturesAdvocate I highly suggest taking a look at Coursera and iversity. If you are self motivated enough to go through with these sites, it's likely you possess the drive to succeed.


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Sobyanin Says Investment in City Economy Hits Pre-Crisis Level
By Alexander Bratersky
Apr. 23 2013 00:00
RIA-NovostiMoscow Mayor Sergei Sobyanin
Moscow Mayor Sergei Sobyanin said Tuesday that investment into the city's economy reached the pre-crisis level, citing commercial real estate as an example.
Twice as much is being invested in Moscow's commercial real estate as in London, he said at a high-profile panel on the city's development held by RIA Novosti.
But both Sobyanin and other officials admitted that the city faced major problems connected to traffic and the investment climate,
"A major part of businesses still work in the shadow economy," he said. "If we continue doing this, we'll ruin the city."
However, he cited as a positive example the fact that the number of private cab drivers working in the city legally increased from 9,000 in 2011 to 30,000 in 2012 due to the reform of the taxi system.
Doing Business: Relax or not?
Sobyanin called on government officials and the business community to look beyond the Doing Business ranking, but said the government should do more to cut red tape.
"We need to relax a bit and to see what's going on in the city without looking at foreign ratings, which can't always be objective," Sobyanin said.
He was referring to the Doing Business ranking, which is drawn up by the World Bank and the International Financial Corporation. Moscow was ranked 112th out of 183 countries in October 2012, an 8 point rise from 2011.
President Vladimir Putin said earlier that Russia aimed to rise to 20th place by the end of his term in office in 2018.
Deputy Mayor Andrei Sharonov said Russia's low position in the ranking was a fact and needed to be taken seriously.
Sharonov, who is responsible for the city's economic policy, also said that, in case of a recession, Moscow would be affected more than the rest of the country, since 90 percent of its taxes are collected by companies and individuals with the greatest exposure to the crisis.
He said, however, that the city's gross regional product had risen steadily and totaled $356 billion in 2012.
Meanwhile, New Economic School Rector Sergei Guriyev said cheaper oil could trigger a drop in other prices, attracting foreign tourists to the city.
"If it happens by the time of the next panel discussion, we will talk not only about investment, but about tourism too," he said during his presentation.
The construction of commercial real estate will reach the pre-crisis level this year, Sobyanin said.
He also said Moscow still had a lot of former industrial zones that needed to be developed.
The development of such zones is the one of the city's biggest problems, Sharonov admitted.
He said, however, that some of them were being developed. The former Zil heavy truck factory, where investors are carrying out a light truck production project in a partnership with Sberbank, is one example, Sharonov said.
He said the problem was aggravated by the existence of multiple owners of property in those areas, who bought them for a song in the 1990s.
"Some of them don't even live in Russia anymore," he said.
Contact the author at a.bratersky@mail.ru
Sobyanin Wants New Roads and a Disneyland - Perhaps by 2020
Sobyanin Tries Out New Unified Commuter Pass
Moscow Leads in Procurement Transparency


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NYPD Union Wants NFL To Let Cops Carry in Stadiums
The leaders of one of New York City's police unions wants the National Football League to allow police officers to...
By David Maccar | Published Nov 19, 2015 11:54 PM
The leaders of one of New York City's police unions wants the National Football League to allow police officers to carry guns in stadiums, in light of the terrorist attacks in Paris.
According to this story from ABC7ny.com, Sgt. Ed Mullins, the president of NYPD's Sergeants Benevolent Association, has created an online petition (which you can view here)with the goal of changing the NFL's standing policy, which prohibits on- and off-duty police as well as retired officers from carrying firearms in NFL stadiums.
As of the afternoon of Nov. 19, the petition had 2,100 supporters with a goal of 2,500.
The petition states: "In light of the recent terrorist attacks in Paris, France, in which a soccer stadium was targeted, the New York City Sergeants Benevolent Association demands that Roger Goodell, the Commissioner of the National Football League, change the policy…This is not only a law enforcement issue, it is a public safety issue that must be immediately addressed. NFL stadiums are often publicly funded and receive monetary incentives paid by tax dollars. We urge all nationwide law enforcement personnel to sign this petition to help put an end to this illogical ruling that puts the lives of so many fans at great risk."
The stadiums of only two teams are exempt from the NFL's rule, the Dallas Cowboys and the Houston Texans, because they both convinced the league that the Texas carry laws supersede the league's policy.
Joe Giacalone, a former police officer and now an adjunct professor at John Jay College of Criminal Justice, said in the story that if officers are allowed to be armed in stadiums, then there should be rules in place about whether or not they are allowed to consume alcoholic beverages while doing so.
For the full story from ABC7ny.com, go here.
Guns in Sports Stadiums


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Mary Batten (born 1937) is an American writer of science books for children and adults. She is also known for writing television productions, films, and magazines, and has won several awards concerning her work in these areas.

Biography
Born in 1937 in Smithfield, Virginia, Batten grew up in a farm, where, as a child, she learned about nature by playing in the woods and near the forest streams. Batten started writing when she was around the age of 7 or 8. In an interview, she revealed that she had wanted to become a writer since she was a child.

Batten went to University of North Carolina from 1955 to 1957. The following two years, she worked as a library clerk at New York Public Library before earning a B.A at New School for Social Research in 1959 and an M.A at Columbia University in 1962.

Batten lives with her husband, Ed Bland, who works as a composer. They have two grown children, Robert Bland, a writer, and Stefanie Batten Bland, a dancer.

Career
Batten's writings focus mostly on environmental and natural issues, including ecology, animals, plants, etc. In order to write, she has visited many tropical rainforests, astronomical observatories, scientific laboratories, and medical research centers. Batten has confirmed that she only writes non-fiction books, and that she feels "lucky to be a science writer" because [she] can follow [her] curiosity". Although Batten does not write fiction books, her writings are influenced by fiction author Flannery O'Connor, as well as non-fiction authors Stephen Jay Gould and Edward O. Wilson. As of 2011, she has written 16 books for adults and children.

In 1992, Batten published "Sexual Strategies: How Females Choose Their Mates," which became one of her most successful books. This book, about the powerful role female mate choice plays in evolution, was released in an updated edition in 2008. "Sexual Strategies is a gem; a beautifully researched and concise introduction to animal mating systems and the clearest available account on the biology of female choice," said Sarah Blaffer Hrdy, Ph.D., Emeritus Professor of Anthropology, University of California, Davis. More information about this book can be found on the book's website, sexualstrategies.com.

In 2001, Batten published Anthropologist: Scientist of the People, which won the 2002 "Outstanding Science Trade Book for Children citation" given by National Science Teachers Association. Several other books of hers are also recommended by National Science Teachers Association: Who Has A Belly Button, Aliens from Earth , Hey, Daddy! Animal Fathers and Their Babies, The Winking, Blinking Sea: All about Bioluminescence. Among them, Hey, Daddy! Animal Fathers and Their Babies, published in 2002, was named "Outstanding Science Read Aloud 2003" by American Association for the Advancement of Science. "Aliens from Earth" won the 2006 Izaak Walton League of America Conservation Book of the Year Award and was adopted by the New York City Public Schools in support of the 4th grade science requirement for the study of ecosystems.

Batten has written many nature documentaries for television, including the Wild, Wild World of Animals series. She also writes for National Geographic and Walt Disney Educational Films. Batten received a nomination for an Emmy Award for her work on a Children's Television Workshop science series, 3-2-1 Contact.

Batten was editor of The Cousteau Society's award-winning magazine, "Calypso Log," from 1987 to 1993. Until 2006, she was editor-in-chief of Breastlink.org, a website dedicated to victims of breast cancer and their families.

Bibliography
Discovery by Chance: Science and the Unexpected 1968.
The Tropical Forest: Ants, Ants, Animals and Plants 1973.
Nature's Tricksters: Animals and Plants That Aren't What They Seem 1992.
The Twenty-five Scariest Hauntings in the World 1996.
Shark Attack Almanac, illustrated by Carol Lyon 1997.
Baby Wolf 1998.
Sexual Strategies: How Females Choose Their Mates 1992; 2008.
The Winking, Blinking Sea: All about Bioluminescence 2000.
Hungry Plants 2000.
Extinct!: Creatures of the Past 2000.
Anthropologist: Scientist of the People 2001.
Wild Cats 2002.
Hey, Daddy!: Animal Fathers and Their Babies 2002.
Aliens from Earth: When Animals and Plants Invade Other Ecosystems 2003.
Who Has a Belly Button? 2004.
Please don't wake the animals 2008.

References

External links
Official website

1937 births
Living people
American science writers
People from Smithfield, Virginia
New York Public Library people
Columbia University alumni
The New School alumni
University of North Carolina alumni

redpajama_set_name: RedPajamaWikipedia


When guided effectively, the relationship between adolescents and music can offer powerful opportunities for expression and release. This book provides music therapists with the complete 'how to' of working with teenage clients.
Helpful and accessible, the book explains the methodology used in music therapy, a topic that has been considered only briefly until now. The author presents an empowering approach to practice, discussing how the therapist can be placed in a collaborative relationship with the individual or with the group. A range of strategies is explored, including song sharing, improvisation, song writing and various multi-media approaches. Some of the key challenges faced by music therapists working with adolescent clients are addressed, including the constantly changing repertoire and evolving musical tastes, and the author offers practical solutions for overcoming these. Contemporary models of Community Music Therapy are outlined in the second half of the book, and case vignettes illustrate how each of the methods can be applied in practice, and the outcomes that may be expected.
The first of its kind, this comprehensive book is a must for all music therapists working with adolescent clients.


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Monday, December 02, 2019, 11:50
Messi goal extends Atletico winless run against Barcelona
Monday, December 02, 2019, 11:50 By Associated Press
FC Barcelona's Lionel Messi celebrates after scoring his opening goal during a Spanish La Liga soccer match between Atletico Madrid and FC Barcelona at Wanda Metropolitano stadium in Madrid, Spain, Dec 1, 2019. (MANU FERNANDEZ / AP PHOTO)
MADRID - Atletico Madrid's ordeal against Barcelona continues in the Spanish league.
Lionel Messi made up for a lackluster performance by scoring in the 86th minute on Sunday, giving Barcelona a 1-0 win at Atletico and extending the Catalan team's unbeaten run against the Madrid rival to 19 league matches.
"It's always a big advantage to have Messi in even games like these," Barcelona coach Ernesto Valverde said.
Messi struck with a low left-footed shot from outside the area after being set up by Luis Suarez to keep Barcelona unbeaten against Atletico for nine years.
It's always a big advantage to have Messi in even games like these
Ernesto Valverde, Coach, Barcelona
ALSO READ: Messi celebrates, Liverpool frustrated in Champions League
"We played a great match, but when Leo shows up he can make a difference," Atletico forward Saul Niguez said. "It's incredibly easy for him to do these things, that's why he is the best."
It was Messi's 30th career goal against Atletico, which hadn't lost at home in 17 matches in all competitions.
"Messi appeared out of the match for a long time, but when he had a chance he broke free and scored a great goal," Atletico coach Diego Simeone said.
The victory put Barcelona back at the top of the league above Real Madrid - which won at Alaves on Saturday - on goal difference.
Atletico dropped to sixth place, six points behind Barcelona and Real Madrid which have a game in hand after their October clasico was postponed until Dec 18 because of a separatist rally in the Catalan capital.
Sevilla stayed third after beating last-place Leganes 1-0 earlier Sunday, while Real Sociedad is in fourth place after routing Eibar 4-1 on Saturday.
"The league is very long, we have to keep working to stay close to the leaders," Simeone said.
The match marked Antoine Griezmann's return to the Wanda Metropolitano Stadium after being transferred to Barcelona at the end of last season. He was loudly jeered by most Atletico fans nearly every time he touched the ball. The France striker had a quiet performance and never posed a significant threat.
Barcelona's Lionel Messi, left, celebrates after scoring his side's second goal with Antoine Griezmann, centre and Luis Suarez during a Champions League soccer match Group F between Barcelona and Dortmund at the Camp Nou stadium in Barcelona, Spain, Nov 27, 2019. (JOAN MONFORT / AP PHOTO)
Atletico had most of the chances at the Metropolitano, but both teams squandered good opportunities throughout the match.
Each side hit the woodwork in the first half, and both goalkeepers - Atletico's Jan Oblak and Barcelona's Marc-Andre ter Stegen - made some good saves to keep the game scoreless.
Messi broke the deadlock after an exchange with Suarez, whose perfect touch just outside the box set up the playmaker's well-placed low shot.
Atletico's last league win over Barcelona was in February 2010, a 2-1 victory at the now demolished Vicente Calderon Stadium. It hadn't lost at the Metropolitano since a game against Real Madrid in February.
Barcelona has won 14 matches against Atletico since that loss in 2010, with five draws. Atletico's last win against Barcelona in all competitions was a 2-1 result in the quarterfinals of the 2015-16 Champions League. Atletico's worst streak against a single club is a 23-match winless run against Real Madrid from 2000 to 2013.
SEVILLA STAYS CLOSE
Sevilla beat Leganes to keep pace with the leaders.
Brazilian defender Diego Carlos scored in the 63rd to give the team its fifth straight win in all competitions.
Julen Lopetegui's squad hasn't lost in 10 matches in all competitions, since a 4-0 rout at Barcelona in the league.
Sevilla's Spanish head coach Julen Lopetegui looks on prior to the Spanish league football match between Sevilla FC and Club Deportivo Leganes SAD at the Ramon Sanchez Pizjuan stadium in Seville, on Dec 1, 2019. (JORGE GUERRERO / AFP)
Leganes is at the bottom of the 20-team standings with six points from 15 matches. It hasn't won in five consecutive league games, with four losses and a draw. Three of the losses came against Real Madrid, Barcelona and Sevilla.
ATHLETIC WINS AGAIN
Athletic Bilbao beat Granada 2-0 at home for its fourth straight victory.
Raul Garcia scored from a penalty kick in the 41st and Yuri Berchiche sealed the win in the 83rd at the San Mames Stadium, putting Athletic in fifth place with 26 points, five behind Barcelona and Real Madrid.
Granada dropped to 10th place, with 21 points.
HOME STRUGGLES
Espanyol remained winless in eight home matches in the league this season after a 4-2 loss to 10-man Osasuna, which played without defender Facundo Roncaglia from the 52nd because of a second yellow card for dangerous play.
READ MORE: Signing of Wu Lei improves Espanyol's finances
Espanyol, which has lost four of its last five league games, stayed second to last with nine points. Osasuna, which had one win in its last four league games, jumped to ninth place.
Also, seventh-place Getafe routed 11th-place Levante 4-0 will all goals coming in the second half.