Trek the Salkantay to Machu Picchu in style and comfort with this 7 day lodge to lodge trekking adventure. Truly a unique way to experience ancient history along a section of the Inca trail through 15 different eco-systems, exploring local villages, a variety of exotic flora and fauna, and stunning mountain peaks and passes. End each day with a hot shower, outdoor Jacuzzi, gourmet meals and select wines in a cozy mountain lodge with highly personalized service. End your trek at a lovely Eco- Lodge in Machu Picchu city and guided tour of the famous Machu Picchu Sanctuary with option to hike the steep Huayna Picchu for even more breathtaking views.
This morning enjoy the stunning scenery with an acclimatization hike from the lodge to glacier-fed Lake Humantay with views of Mt. Salkantay, a sacred mountain in Incan mythology. Return to the lodge for lunch.
This is the big day! After an early start, hike up the Rio Blanco valley, circling Humantay Peak across from Salkantay Peak. The highest point on the trek is the Salkantay Pass at 4,638 m (15,213 ft). At the pass stop to take in views of snowcapped peaks of the Vilcabamba Range in every direction, the glaciated south face of Salkantay towering above us. Keep your eyes out for Andean condors, often visible in this area. From the pass descend towards Wayra Lodge ("Wayra" means wind; so 'the place where the wind lives') our destination for the evening. A hot lunch is served en route; dinner and overnight at the Lodge.
Transportation of personal belongings by pack horses/mules and/or porters.
Tips for lodge staff (except Guide & muleteer tips).
Transportation (Train to Aguas Calientes, and Ollantaytambo).
At the lodges provided are filtered and sparkling water, tea and coffee, juice and soft drinks free of charge. Alcohol, sports drinks and natural bottled water are not included.


Ok, here's the thing. Technically chocolate, even raw cacao, is not SCD legal. BUT I can't find a very good reason for this. One potential reason is that it is potentially addictive (duh, but so is coffee–much more so, actually–and it is allowed with caveats) and another is that cacao is a chemically complex food that might contain trace amounts of illegal carbohydrates (sucrose, to be specific), as well as compounds that aid in the reproduction of viruses and suppress the immune system.
On the other hand, there is tons of solid information coming out about how nutritious cacao can be. One ounce of cocoa contains nearly a quarter of the recommended daily value of iron, 35 % RDV of magnesium, and over 50% RDV of copper and manganese. It's a good source of protein, fiber, and numerous essential minerals–many of which are chronically deficient in IBD sufferers. Additionally, cocoa is very high in antioxidants, which protect against aging, cardiovascular disease, cancer, and even inflammation. Consumption of cacao is allowed–and even encouraged–in some other gut restorative diets such as GAPS and paleo. So, I'm sorry, Elaine, but you'll have to provide me with a better argument to get me to give up cocoa.
Not all chocolate is created equal, however. Fermenting and processing can significantly reduce the antioxidants available in chocolate, and other ingredients usually used to make chocolate–such as sugars, milk, and certain preservatives–are (convincingly) problematic for people with IBD. If you are going to indulge in chocolate, it's so much better for you to make your own so that you can control your ingredients. It can take a little hunting to track down the ingredients you need, but once you acquire them they should last for a good amount of time. I use this cacao powder, which is raw and only partially fermented to preserve as many antioxidants as possible. This is my source of cocoa butter. I hear you can buy it at Whole Foods, but I don't go to Whole Foods regularly, and anyway the wafer form is super easy to measure.
I got the basic chocolate recipe from this site, but my husband is addicted to these delicious coconut-covered almond chocolates from Sprouts and I was inspired by them, along with a glut of raw hazelnuts, to come up with a new filling. If you don't want to make your own nut butter filling, you can also use a prepared one from the store (just check the ingredients). I have also made these with a layer of almond butter and a layer of coconut butter, and they are quite tasty.
Once you've roasted the nuts, turn them out into a clean kitchen towel and wrap them up to steam for a few minutes.
Peel them as well as you can but don't worry about some skins sticking around.
Here is what the butter should look like once well combined and processed.
Use a double boiler to melt your chocolate and honey. Or, you know, just a bowl on top of a pot. Whatever.
Stir into the cacao and vanilla and keep stirring until very smooth. I like to do this in a measuring cup so it's easy to pour.
Pour in a bit of chocolate.
Then more chocolate. Don't worry about perfection. You can remove extra chocolate once the candies are set.
Then just pop them out of the mold and enjoy!
Roast raw hazelnuts in a baking pan for 15-20 minutes, until fragrant and browned but not burned. Pour into a clean kitchen towel and let steam for a few minutes. When cool enough to handle, rub together in the towel or between your hands to remove most of the peels. Don't worry if you can't get all of them off.
Place hazelnuts, coconut butter, and salt in food processor and process until smooth. If the nut butter is not smooth enough for your taste, keep adding coconut butter or coconut oil until you achieve the desired consistency. I keep mine quite thick so that it holds together better. Taste and add more salt if desired. I like mine a bit salty to contrast with the sweet chocolate.
Heat about 1 inch of water in the bottom part of a double boiler over medium-low heat. Add in the honey and cocoa butter and stir until melted.
Combine honey and cocoa butter with cacao powder and vanilla extract. Be very careful not to get any water in the mixture at this point or else it can make your chocolate grainy. Taste and adjust to your liking by adding more honey or more cacao.
Pour a thin layer of chocolate into the bottom of a silicone chocolate mold (like this one)*. Spoon in a layer of the nut butter. Then top off again with another layer of chocolate. Cover the mold with parchment paper and refrigerate until set.
Pop out of the molds and store in refrigerator. Consume within 7 days for best taste and texture (but I bet they won't last that long!).
*Note: if you don't have a chocolate mold and don't want to buy one, just linea glass dish or rimmed cookie sheet with parchment paper and pour half the chocolate on top. Then, top with the hazelnut butter, and then the other half of the chocolate. Swirl with a knife. Once it has hardened a bit in the refrigerator, cut into pieces and peel off parchment paper. I usually have a bit of chocolate and hazelnut butter left over, anyway, and this is how I avoid waste!


text:
https://www.wsj.com/articles/cmo-today-googles-ad-blocker-blue-apron-ipo-audience-science-closes-1496403850
CMO Today Newsletter
CMO Today: Google's Ad Blocker; Blue Apron IPO; Audience Science Closes
Here's your morning roundup of the biggest marketing, advertising and media industry news and happenings.
Sridhar Ramaswamy, Google's senior vice president of ads and commerce.
Photo: Laura Cavanaugh
Lara O'Reilly
@larakiara
lara.oreilly@wsj.com
Updated June 2, 2017 7:50 am ET
Good morning. The corporate PR machine was whipped into action Thursday after President Donald Trump announced plans to pull the U.S. from the Paris climate change agreement. Executives from Disney's Bob Iger to Tesla's Elon Musk took to Twitter to denounce the move. Goldman Sachs CEO Lloyd Blankfein even sent his first-ever tweet to call the Paris accord withdrawal a "setback for the environment and for the U.S.'s leadership position in the world."
When in Chrome
We have more details about Google's plan to build an ad "filter" into the Chrome web browser, courtesy of Jack Marshall at CMO Today. Not only is Google launching a blocker filter in 2018, but the company has been testing a tool for publishers called "Funding Choices" that will encourage users of other ad blockers to switch them off or make a micropayment in order to view their content. Google is a customer of Eyeo, the German company that owns Adblock Plus and charges big advertising companies to get their ads whitelisted. Combined, these moves appear to undermine other ad blockers, while safeguarding its own ads, in the name of protecting consumers.
--How Far Will It Go?--
The Chrome filter will block ads that don't adhere to the standards of trade group the Coalition of Better Ads. So far those standards cover only aesthetics: pop-ups, autoplay videos and so on. Research from YouGov last year suggested "annoying" ads such as these are the main motivations for ad blocking, but many people (39% of respondents) also use ad blockers to avoid being tracked across websites, and more than half of respondents (55%) said they do so to protect themselves from malware and viruses. I wonder if the Coalition -- comprised of online ad companies, ad trade bodies, agency groups and publishers -- will extend the standards to protect consumers from these aspects of online ads, too *thinking face emoji*.
It Takes an Apron of Millions to Hold Us Back
Meal-kit-delivery service Blue Apron has filed for an IPO, and the S-1 offers a fascinating insight into how much the company spends on marketing to acquire new customers. In 2016, Blue Apron spent 18% of its net revenue, $144.1 million, on marketing, and that expenditure is growing: In the first three months of 2017, marketing represented almost 25% of the company's net revenue. Blue Apron says the average amount it spent to acquire each customer since 2014 was $94, but, as Recode points out, if you look at only the past 12 months, that average shoots up to around $460 a customer. What's worse is that the company's average order value, orders per customer and revenue per customer are all down in the past year. Yikes. Now Blue Apron says it's changing tack and will increase the portion of its budget devoted to advertising on offline channels to boost brand awareness. It'll also focus on customer retention, including plans to increase order flexibility.
Procter & Gambled
Ad tech company Audience Science, which offered marketers a combined demand-side and data-management platform to automate the buying of online ads, shut down Thursday, AdExchanger reports. Audience Science's closure comes less than a month after Procter & Gamble - its biggest client and source for an overwhelming majority of its revenue - pulled the plug on their relationship. Audience Science's unsurprising shuttering is a bleak reminder of the dangers of relying on a single customer, particularly one that forbade the firm from talking publicly about their partnership and has been vocal recently about cutting millions of dollars in advertising costs
Facebook is working on a teen messaging app. [The Information]
The European Union has praised YouTube, Facebook, Twitter and Microsoft's efforts to remove hate speech from their platforms in a report released Thursday. [WSJ]
Potbelly Sandwich Shop is working with Michigan State University to see if social media ads can make you happy. [Digiday]
Burger King has withdrawn a campaign that angered the Belgian royal family. [Adweek]
Fox's National Geographic network canceled plans for the latest TV movie adaptation of Bill O'Reilly's "Killing" book series. [Hollywood Reporter]
U.S. cable news viewership increased in 2016, but newspaper circulation continued to fall precipitously. [Pew Research Center]
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redpajama_set_name: RedPajamaCommonCrawl


text:
Clinical data
Enbrel, Benepali
License data
EU EMA: by INN
US: B (No risk in non-human studies)
Routes of
L04AB01 (WHO)
AU: S4 (Prescription only)
UK: POM (Prescription only)
US: ℞-only
Pharmacokinetic data
58–76% (SC)
Reticuloendothelial system (speculative)
Elimination half-life
PubChem SID
OP401G7OJC
CompTox Dashboard (EPA)
Chemical and physical data
C2224H3475N621O698S36
51234.9 g/mol g·mol−1
Etanercept (trade name Enbrel or Benepali) is a biopharmaceutical that treats autoimmune diseases by interfering with tumor necrosis factor (TNF, a soluble inflammatory cytokine) by acting as a TNF inhibitor. It has U.S. F.D.A. approval to treat rheumatoid arthritis, juvenile idiopathic arthritis and psoriatic arthritis, plaque psoriasis and ankylosing spondylitis. TNF-alpha is the "master regulator" of the inflammatory (immune) response in many organ systems. Autoimmune diseases are caused by an overactive immune response. Etanercept has the potential to treat these diseases by inhibiting TNF-alpha.[1]
Etanercept is a fusion protein produced by recombinant DNA. It fuses the TNF receptor to the constant end of the IgG1 antibody. First, the developers isolated the DNA sequence that codes the human gene for soluble TNF receptor 2, which is a receptor that binds to tumor necrosis factor-alpha. Second, they isolated the DNA sequence that codes the human gene for the Fc end of immunoglobulin G1 (IgG1). Third, they linked the DNA for TNF receptor 2 to the DNA for IgG1 Fc. Finally, they expressed the linked DNA to produce a protein that links the protein for TNF receptor 2 to the protein for IgG1 Fc. The prototypic fusion protein was first synthesized and shown to be highly active and unusually stable as a modality for blockade of TNF in vivo in the early 1990s by Bruce A. Beutler, an academic researcher then at the University of Texas Southwestern Medical Center at Dallas, and his colleagues.[2][3]
These investigators also patented the protein,[4] selling all rights to its use to Immunex, a biotechnology company that was acquired by Amgen in 2002.[5]
It is a large molecule, with a molecular weight of 150 kDa, that binds to TNFα and decreases its role in disorders involving excess inflammation in humans and other animals, including autoimmune diseases such as ankylosing spondylitis,[6] juvenile rheumatoid arthritis, psoriasis, psoriatic arthritis, rheumatoid arthritis, and, potentially, in a variety of other disorders mediated by excess TNFα.
1 Medical uses
3 Mechanism of action
6 Society and culture
6.1 Marketing
6.2 Sales
6.3 Patents
7 Similar agents
Medical uses[edit]
In the U.S. the FDA has licensed Enbrel for :
Moderate to Severe Rheumatoid Arthritis (RA) (Nov 1998)[7]
Moderate to Severe Polyarticular Juvenile Rheumatoid Arthritis (May 1999)[8]
Psoriatic Arthritis (Jan 2002)[9]
Ankylosing Spondylitis (AS) (July 2003)[10][11]
Moderate to Severe Plaque Psoriasis (April 2004)[12]
Safety[edit]
On May 2, 2008, the FDA placed a black box warning on etanercept due to a number of serious infections associated with the drug.[13] Serious infections and sepsis, including fatalities, have been reported with the use of etanercept including reactivation of latent tuberculosis and hepatitis B infections.[14][15]
There has also been a report of strongyloides hyperinfection after use of etanercept.[16]
Mechanism of action[edit]
It reduces the effect of naturally present TNF, and hence is a TNF inhibitor, functioning as a decoy receptor that binds to TNF.[17]
Tumor necrosis factor-alpha (TNFα) is a cytokine produced by lymphocytes and macrophages, two types of white blood cells. It mediates the immune response by attracting additional white blood cells to sites of inflammation and through additional molecular mechanisms that initiate and amplify inflammation. Inhibition of its action by etanercept reduces the inflammatory response, which is especially useful for treating autoimmune diseases.
There are two types of TNF receptors: those found embedded in white blood cells that respond to TNF by releasing other cytokines, and soluble TNF receptors that are used to deactivate TNF and blunt the immune response. In addition, TNF receptors are found on the surface of virtually all nucleated cells (red blood cells, which are not nucleated, do not contain TNF receptors on their surface). Etanercept mimics the inhibitory effects of naturally occurring soluble TNF receptors, the difference being that etanercept, because it is a fusion protein rather than a simple TNF receptor, has a greatly extended half-life in the bloodstream, and therefore a more profound and long-lasting biologic effect than a naturally occurring soluble TNF receptor.[18]
Structure[edit]
Etanercept is made from the combination of two naturally occurring soluble human 75-kilodalton TNF receptors linked to an Fc portion of an IgG1.[19] The effect is an artificially engineered dimeric fusion protein.[19] Etanercept is a complex molecule containing 6 N-glycans, up to 14 O-glycans and 29 disulfide bridge structures.[20][21][22]
The fusion protein was developed by Bruce A. Beutler, an academic researcher then at the University of Texas Southwestern Medical Center at Dallas, and colleagues, who patented it and sold the rights to Immunex.
Society and culture[edit]
Marketing[edit]
In North America, etanercept is marketed by Amgen under the trade name Enbrel in two separate formulations, one in powder form, the other as a pre-mixed liquid. Wyeth (now part of Pfizer) was the sole marketer of Enbrel outside North America excluding Japan where Takeda Pharmaceuticals markets the drug.
Sales[edit]
The U.S. retail price of Enbrel has risen over time. In 2008, the cost of Enbrel was $1,500 per month or $18,000 per year.[23] By 2011, the cost had exceeded $20,000 per year.[24][25] In 2013, a survey by the International Federation of Health Plans (IFHP) found that the average U.S. cost for Enbrel was $2,225 per month, or $26,700 per year.[26] The IFHP report also found wide variation in prices charged to various U.S. health plans, between $1,946 per month at the 25th percentile and $4,006 per month at the 95th percentile.[26]
Enbrel is more expensive in the U.S. than in other countries.[26] As of 2013, average monthly costs in surveyed nations ranged from $1,017 in Switzerland to $1,646 in Canada, compared to an average monthly cost of $2,225 per month in the U.S.[26]
Amgen sells Enbrel within the U.S. and Canada, while Pfizer, Inc. sells the drug outside of the U.S. and Canada.[24] Sales within the U.S. and Canada were $3.5 billion in 2010.[24] Sales of Enbrel outside the U.S. and Canada were $3.3 billion in 2010.[27]
Patents[edit]
The patent on Enbrel was originally set to expire on October 23, 2012,[28] but, in the United States, a second patent, granting exclusivity for another 16 years, has been granted.[29]
Before the extension it seemed unlikely that a generic would have been available. As a biologic, etanercept is subject to different laws from those applicable to chemical formulations. Currently many countries do not permit the manufacture of generic biologics. However, the European Union and the United States (Biologics Price Competition and Innovation Act of 2009) do currently have in place a system to approve generic biologics (biosimilars) which "requires mandatory clinical testing and periodic review".[30]
In April 2013, the Indian pharma major Cipla made an announcement about launching the first biosimilar of Etanercept in India under the brand name 'Etacept' for the treatment of rheumatic disorders. The company's April 17, 2013 press release claimed that the biosimilar will cost 30% less as compared to the innovator.[31]
In January 2015, Samsung and Biogen's joint venture "Samsung Bioepis" successfully submitted Benepali, a biosimilar version of the drug, for review to the European Medicines Agency (EMA), and announced that it will seek regulatory approvals in other territories as well. Later the same year, the European Medicines Agency also accepted Sandoz's application for review of its etanercept biosimilar Erelzi which will be marketed by Novartis.[32]
In the U.S., Sandoz submitted a biologics license application (BLA) for the proposed etanercept product "GP2015" in July 2016. Upon acceptance of the first application process, the U.S. FDA reviewed data from European clinical trials and bio-analytical investigations, demonstrating the biosimilarity of GP2015 to the US-licensed Enbrel. Sandoz in 2009 tried to invalidate the patents held by Hoffman-La Roche/Immunex and exclusively licensed to Amgen but lost in federal court. Sandoz was then countersued by Amgen for patent infringements related to the methods of treating psoriasis and/or psoriatic arthritis. The case Immunex Corp. et al. vs. Sandoz Inc. et al., 16-cv-01118-CCC-JBC (D.N.J.) is pending.[33]
Similar agents[edit]
Soluble TNF receptor
Pegsunercept
Anti-TNF monoclonal antibodies
Certolizumab pegol
^ Feldmann M, Maini RN (October 2003). "Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases". Nature Medicine. 9 (10): 1245–50. doi:10.1038/nm939. PMID 14520364.
^ Peppel K, Crawford D, Beutler B (December 1991). "A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity". The Journal of Experimental Medicine. 174 (6): 1483–89. doi:10.1084/jem.174.6.1483. PMC 2119031. PMID 1660525.
^ Peppel K, Poltorak A, Melhado I, Jirik F, Beutler B (November 1993). "Expression of a TNF inhibitor in transgenic mice". Journal of Immunology. 151 (10): 5699–703. doi:10.1073/pnas.91.1.215. PMID 7693816.
^ U.S. Patent number: 5,447,851
^ "Arthritis Drug Effective for Depression in Psoriasis Sufferers". Archived from the original on 2007-10-20. Retrieved 2008-01-10.
^ Braun J, McHugh N, Singh A, Wajdula JS, Sato R (June 2007). "Improvement in patient-reported outcomes for patients with ankylosing spondylitis treated with etanercept 50 mg once-weekly and 25 mg twice-weekly". Rheumatology. 46 (6): 999–1004. doi:10.1093/rheumatology/kem069. PMID 17389658.
^ Siegel JP (November 2, 1998). "Approval of Etanercept for treatment of rheumatoid arthritis" (PDF). Letter to Sally Gould. Food and Drug Administration. Retrieved April 14, 2015.
^ Weiss, Karen D. (May 27, 1999). "Approval of Etanercept for treatment of polyarticular course juvenile rheumatoid arthritis (JRA)" (PDF). Letter to Sally Gould. Food and Drug Administration. Retrieved April 14, 2015.
^ Weiss KD (January 15, 2002). "Approval of Etanercept for treatment of psoriatic arthritis". Letter to Sally Gould. Food and Drug Administration. Retrieved April 14, 2015.
^ Keegan P (July 24, 2003). "Approval of Etanercept for treatment of ankylosing spondylitis" (PDF). Letter to Douglas Hunt. Food and Drug Administration. Retrieved April 14, 2015.
^ Maxwell LJ, Zochling J, Boonen A, Singh JA, Veras MM, Tanjong Ghogomu E, Benkhalti Jandu M, Tugwell P, Wells GA (April 2015). "TNF-alpha inhibitors for ankylosing spondylitis". The Cochrane Database of Systematic Reviews. 4 (4): CD005468. doi:10.1002/14651858.CD005468.pub2. PMID 25887212.
^ Walton M (April 30, 2004). "Approval of Etanercept for treatment of moderate to severe plaque psoriasis" (PDF). Letter to Douglas Hunt. Food and Drug Administration. Retrieved April 14, 2015.
^ "Wyeth and Amgen heighten warning of life-threatening infections on skin drug Enbrel". Archived from the original on 2008-05-05. Retrieved 2008-05-02.
^ Safety Update on TNF- α Antagonists: Infliximab and Etanercept (PDF). Food and Drug Administration. pp. 13–14. Retrieved 20 December 2013.
^ "Prescribing Information – Enbrel". Archived from the original on 2007-10-14. Retrieved 2008-01-10.
^ "UpToDate".
^ Zalevsky J, Secher T, Ezhevsky SA, Janot L, Steed PM, O'Brien C, Eivazi A, Kung J, Nguyen DH, Doberstein SK, Erard F, Ryffel B, Szymkowski DE (August 2007). "Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity to infection". Journal of Immunology. 179 (3): 1872–83. doi:10.4049/jimmunol.179.3.1872. PMID 17641054.
^ Madhusudan S, Muthuramalingam SR, Braybrooke JP, Wilner S, Kaur K, Han C, Hoare S, Balkwill F, Ganesan TS (September 2005). "Study of etanercept, a tumor necrosis factor-alpha inhibitor, in recurrent ovarian cancer". Journal of Clinical Oncology. 23 (25): 5950–59. doi:10.1200/JCO.2005.04.127. PMID 16135466.
^ a b Smola MG, Soyer HP, Scharnagl E (October 1991). "Surgical treatment of dermatofibrosarcoma protuberans. A retrospective study of 20 cases with review of literature". European Journal of Surgical Oncology. 17 (5): 447–53. PMID 1936291.
^ Houel S, Hilliard M, Yu YQ, McLoughlin N, Martin SM, Rudd PM, Williams JP, Chen W (January 2014). "N- and O-glycosylation analysis of etanercept using liquid chromatography and quadrupole time-of-flight mass spectrometry equipped with electron-transfer dissociation functionality". Analytical Chemistry. 86 (1): 576–84. doi:10.1021/ac402726h. PMID 24308717.
^ Mukai Y, Nakamura T, Yoshikawa M, Yoshioka Y, Tsunoda S, Nakagawa S, Yamagata Y, Tsutsumi Y (November 2010). "Solution of the structure of the TNF-TNFR2 complex". Science Signaling. 3 (148): ra83. doi:10.1126/scisignal.2000954. PMID 21081755.
^ Lamanna WC, Mayer RE, Rupprechter A, Fuchs M, Higel F, Fritsch C, Vogelsang C, Seidl A, Toll H, Schiestl M, Holzmann J (June 2017). "The structure-function relationship of disulfide bonds in etanercept". Scientific Reports. 7 (1): 3951. doi:10.1038/s41598-017-04320-5. PMC 5479810. PMID 28638112.
^ "What's behind the whopping price tags on the newest generation of drugs: The story behind the production of Enbrel, Amgen's popular rheumatoid arthritis drug, provides insights as to why bioengineered drugs are so expensive." Carol M. Ostrom, Seattle Times, August 18, 2008
^ a b c "Patent for Amgen Drug May Undercut Health Care Plan", Andrew Pollock, New York Times, November 23, 2011
^ "Co-pay hike a painful reality; Miracle drug monthly cost jumps from $42 to $600", Margery Eagan, Boston Herald, November 3, 2011
^ a b c d "2013 Comparative Price Report" (PDF). International Federation of Health Plans. Retrieved 24 November 2017.
^ "Portions of the 2010 Financial Report". Sec.gov. Retrieved 2019-06-05.
^ "Patent Terms Extended Under 35 USC §156".
^ "New Amgen Enbrel patent could block biosimilars until 2028". 2011-11-25. Retrieved 2019-07-14.
^ Kaldre I (2008). "The Future of Generic Biologics: Should the United States "Follow-On" the European Pathway?". www.law.duke.edu. Retrieved 2019-06-05.
^ "Cipla - Home" (PDF). Cipla.com. Retrieved 2019-06-05.
^ Biosimilar etanercept submitted for approval in EU GaBI Online – Generics and Biosimilars Initiative (Jan 2015). Retrieved 13 July 2016.
^ FDA Briefing Document Arthritis Advisory Committee Meeting July 13, 2016. FDA AAC Brief. BLA 761042, GP2015, a proposed biosimilar to Enbrel. Retrieved 13 July 2016.
Wikimedia Commons has media related to Etanercept.
Amgen/Wyeth Enbrel site
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See here instead.
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Promegapoietin
Thrombopoietin (THPO, MGDF)
IFNAR (α/β, I)
Agonists: Albinterferon
Interferon alpha (interferon alfa, IFN-α)
Interferon alfa (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21)
Interferon alfa 2a
Interferon alfa 2b
Interferon alfa n1
Interferon alfacon-1
Interferon alpha-n3
Interferon beta (IFN-β) (IFNB1, IFNB3)
Interferon beta 1a
Interferon beta 1b
Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
Interferon omega (IFN-ω, IFNW1)
Peginterferon alfa-2a
Peginterferon alfa-2b
Antibodies: Anifrolumab
MEDI-545
Rontalizumab
Sifalimumab
Decoy receptors: Bifarcept
IFNGR (γ, II)
Agonists: Interferon gamma (IFN-γ)
Interferon gamma 1b
Antibodies: Emapalumab
IFNLR (λ, III)
See IL-28R (IFNLR) here instead.
TGFβ
(inhibitors)
JAK1
Filgotinib
Momelotinib
Tofacitinib (tasocitinib, CP-690550)
Upadacitinib
AG-490
Atiprimod
AZD-1480
CHZ868
Cucurbitacin I (elatericin B, JSI-124)
CYT387
Lestaurtinib
NSC-33994
Pacritinib
Cercosporamide
Decernotinib (VX-509)
TCS-21311
WHI-P 154
ZM-39923
ZM-449829
Additional cytokines: Cardiotrophin 1 (CT-1)
FMS-like tyrosine kinase 3 ligand (FLT3L)
Leukemia/leukocyte inhibitory factor (LIF)
Oncostatin M (OSM)
Thymic stromal lymphopoietin (TSLP)
Additional cytokine receptor modulators: Emfilermin
Midostaurin
Quizartinib
Receptor/signaling modulators
Signaling peptide/protein receptor modulators
Growth factor receptor modulators
Retrieved from "https://en.wikipedia.org/w/index.php?title=Etanercept&oldid=931452656"
TNF inhibitors
Pfizer products
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It doesn't matter at what season you are in; grilling is always fun and joyous. With the smell of the meat or vegetables that are being grilled, it just makes your mouth salivating. And the best part of grilling is that it can be done anywhere, at any place, and at any time, unless the people around you really don't like food and dislikes grilling.
For a little bit of history, grilling was for the most part used in campsites and picnic. It was necessary back then because in order to cook anything else, utensils and other things were needed. Hence grilling just fit right in with the situation. But after World War II, backyard grilling started to become a thing and it caught on very fast. It went from nearby parks, house communities, to even a family BBQ gathering.
Grilling has spread so wide that in fact different methods and ways of grilling were also introduced. Back in the day, if you were thinking of grilling, you'd need a grill pit in the backyard. But what if we told you that at this day of age, you can grill on your stove. What if we said that it's the same old flavor but a lot easier.
Grilling is fun and it's a great way to gather your friends around and have a party. But depending on your situation or of where you are, how you are going to grill can depend. But we are all assuming and we are sure of it that you all have a kitchen. And sometimes, you might feel like grilling but you just don't have the grilling machine.
But later you find that you can grill in the kitchen using grill pans. And we are also assuming that this is why you are here. Now this all can be confusing and because of all this, we have searched, found and reviewed some of the best grill pans that are available on the market today. And as we go through, we will talk about these pans and give you people some heads up of what is what, so that you can be aware and understand of what you buy.
The Lodge LPGI3 is an interesting type of grill because it's more of a griddle than a grill pan. First thing first, the construction of this griddle is of iron cast. Because of iron cast, it's highly durable and is recommended for any heavy grilling or any high heat usage.
And since this is made of iron cast, pre-seasoning is an issue but this griddle comes pre-seasoned, hence you don't have to worry about it after buying it. The dimension of this griddle is 20 x 10.44 inch which gives you a very wide space for you grilling that is perfect if you want to lay out your veggies and meat.
Now when it comes to features, the Lodge LPGI3 has many with the most notable it being a reversible grill. Because of this option of being reversible, you can grill depending on your needs and also increases versatility, so you can cook pancakes, eggs, hotdogs etc. Because of the size and flat design, you can use it on a stove, inside an oven, on a pit or at any place you see fit.
Iron cast construction makes the grill pan/ griddle very durable and heavy. And because of this, rough cooking in high heat is easy with this grill pan.
When anything is made of Iron cast, seasoning can be an issue, and while that can be the case for this pan in the long term, but for the short term; it comes pre-seasoned hence you don't have to worry about seasoning it from the get go.
Because of the dimension of the pan/griddle, it gives you enough space to cook various types of food.
The reversible feature allows you to in 2 different methods each with their own advantages. This gives you the freedom to grill however you want.
We have another Lodge amongst ourselves but this time it's a pan instead of a griddle. From the get-go, you can see that this is constructed of cast iron. This hard construction gives the rigidity of harsh use which is what you need for grilling, whether it is inside the house or outside.
The pan comes pre-seasoned since it's made of cast iron, so you don't need to worry about seasoning it after buying it and can use it from the start. This is a 10.5 inch pan, which gives you enough space to grill your large piece of chicken or a steak. The grill pan also has a space for hanging your grill pan.
The pan comes with grilled styled surface making it suitable for steak and chicken. Because of the material of the pan, you can use this grill pan on various heat surfaces like the gas stove, campfire, oven etc.
The Lodge L8SGP3 is made out of cast iron that makes it extra durable and long lasting.
The grill pan also comes pre-seasoned; hence you don't need to worry about seasoning it and can start grilling right after buying it.
This grill pan is a 10.5 inch grill pan. The space is moderate enough for grilling various types of food.
At the front of the pan, there is a space where you can use it to hang your grill if you so have the ability.
Cuisinart is a well-known company when it comes to company utensils. Cuisinart CI30-23CR is a cast iron grill pan with porcelain enamel. Because of the porcelain enamel exterior, it gives the grill pan a vibrant color and a more premium feeling.
The cast iron surface on the inside is perfect for all your grilling needs. And because of the unique collaboration with porcelain and cast iron, the Cuisinart CI30-23CR really shows its toughness in style.
This grilling pan is very versatile meaning you can use this grill pan in an oven, on an induction cooker, or can even use it for broiling. But one of the unique aspects about this grill pan is that on the left side, you can see that there is a small part that is curved making it more like a tip that can be helpful when cooking something gravy. Also, this pan is dishwasher safe so that is always a good thing because it saves time on your part.
The cast iron makes the pan more durable and can be used in harsh conditions without damaging the grill pan.
The porcelain enamel on the outside makes Cusinart CI30-23CR very vibrant, luxurious and unique. With the combination between cast iron and porcelain enamel, it ensures that both heat distribution and durability are increased.
With all being great n all, having the ability to have your dishes be dishwasher safe is always a thing to cherish. And with that, the Cuisinart CI30-23CR is dishwasher safe and that can give you a sigh of relief.
This is an interesting one that really sticks well with our Lodge LPGI3 fella but with more interesting tidbits. Now, Weber 6435 grill pan follows in the accessory departments in the Weber range of products. But that doesn't mean you can't use this product on other things.
But unfortunately, the Weber 6435 grill pan cannot be used on a gas stove. It is recommended that you use it on charcoal or gas grills. To be precise, this piece of equipment is usable with Weber Q300/3000 and larger gas grills, 22 inch and larger charcoal grills. Now you can ask me of why is this a grill pan when you need a grill to use this grill pan.
Well, since this falls in the Weber accessory department for their grills, this is more used as an accessory rather than a whole product. But the reason of why we have put this in our review is because this is a grill pan and it is used for grilling but for specific purposes.
Now that all that is out of the way, we can focus on the component itself. The bare construction of this grill pan is of stainless steel. Since you will not be using this grill pan on any direct heat source, aluminum is perfect for this product. Because of its bare minimum construction, the usage gets pretty simple.
This grill is recommended for using when grilling fish or any delicate type of produce that may break or fall while being grilled. The flat surface gives this grill pan ability to secure your fragile food while helping it keep its original purpose. The surface of the grill pan is designed in such a way that the heat can spread evenly and have better air and heat flow.
While this may not be a feature but this is a specific requirement, hence making this more of a feature if the requirements are met. This professional grade grill pan from Weber is recommended to be used on grills and not on any stoves. And to be precise, this grill pan is usable with Weber Q300/3000 and bigger gas grills, 22 inch and larger charcoal grills.
The stainless steel construction gives this grill a very sharp and professional look. Because it's stainless steel, the heat is spread evenly knowing the fact that you are using it on top of a grill.
The main reason for this grill pan to exist is for the fishes and the delicate ones. Because of the design and the construction, this pan is best used when grilling the soft and squishy ones that tend to break as it gets grilled.
The Calphalon grill pan is a simple pan that is packed with ideas and design that makes this grill pan very unique. Right off the bat, we see that this pan is constructed with heavy gauge aluminum. Now, heavy gauge aluminum is good for heat spread but not necessarily a great material for grilling.
But the heavy gauge aluminum has been hard anodizedwhich helps it increase its rigidity. Now, the pan is nonstick and in fact has 3 layers of nonstick coating, which helps in your grilling and because of the high ridges, your produce get grilled perfectly and gives you that authentic texture.
Due to the size and the design of the grill pan, you can use this pan on various heat source starting from the gas stove, induction to even stove. This is an 11 inch grill pan that gives you a good amount of space for your meat or long veggies. This grilling pan is also dishwasher safe; hence you don't have to worry about spending your time washing it.
The heavy gauge aluminum is lighter than most commercialized metal and it is good fo heat spread but is not good on the durability part. But this heavy gauge aluminum has been anodized making it tougher than before.
This grill pan consists of 3 layers of nonstick coating ensuring that you can grill you meat to perfection without your good beings damaged.
11 inch size makes this pan fall in the above average size section which is good thing since now you have more space for grilling.
This pan is dishwasher safe, so you don't need to worry about scrubbing it away after a perfectly fun time of grilling and eating.
A very unusual designed grill pan from TeChef, but with many unique features. To start off with, the design and the color is very unique and premium looking. You have to understand that this is a Korean BBQ grill pan. Now while they have their own ways of grilling, nevertheless, this is a grill pan and you can also grill your food very easily.
The unique circular shape and the swirl design on the surface actually have a purpose. Because of the different levels of surface, it helps your produce gets grilled just like the standard grills. At the edge of the surface you can see that the swirl shapes have uplifted and that is due to the feature of removing extra fat.
Because of the swirl design, not only it helps you grill your meat but also helps you reduce the fatty oil by draining it through the hole that can be found on the edge of the pan. And that is why, the pan is also a bit dome shaped, so that the excess oil can run down. The grill pan is coated with 5 layers of Dupont Teflon nonstick coating which is PFOA free.
This ensures that the coating won't harm you and you can grill to your desires without toxins contaminating your food. Also, the printed coating design helps it looks more lavish and is a great addition to your kitchen. One thing to remember though that this grill pan should only be used on gas stove only. Of course you can use it outdoors but it is recommended for gas stove use only.
The design of this grill pan is spectacular. Obviously understanding that this grill pan is a Korean BBQ grill pan, this grill pan is dome shaped for removing excessive oil without having to move the pan as it runs through the swirl patterned ridges. Near the edge of the pan, the surface is a bit uplifted causing it to separate your grilled food and fatty oils nearby and not to mention better airflow for grilling.
This grill pan comes with 5 layers with Dupont Teflon nonstick coating, making it immensely easy for you to cook your meat without it being ruined. Also this coating is also PFOA free; hence you don't have to worry about any toxins in your food.
Since this is Korean BBQ, gas stoves are the only accessibility over here when using this grill pan, although, you can use this product both indoors and outdoors.
Rachel Ray is pretty famous in the kitchen utensils department and her products really touch the basics of cooking but also give you just enough to make your experience in cooking into a whole another level.
The grill pan from Rachel Ray is of aluminum that is anodized, which helps greatly in durability and sturdiness. The edges of the pan are pretty high and it can help you in controlling your food as you move them in the pan. Also it can be helpful of oils splattering everywhere as you drop your food into the grill pan.
The Pan is nonstick, which helps you in grilling as your food won't be stuck to the surface of the pan. The handle bar is rubberized for your convenience but is heat resistant up to 350 degree Fahrenheit. The pan is also dishwasher safe, so you won't have to worry about spending your time washing it manually.
The edges of the pan are very high helping you to cook much more safely, especially from those pesky hot oils that just jump out of nowhere.
The pan is nonstick that will help you in cooking much more easily and non to mention it's much easier to clean those fatty oils after grilling.
This pan is dishwasher safe which is always a good thing and is highly appreciated.
This hard anodized aluminum grill pan from Anolon sticks with simplicity and sometimes, simple things can excel at things far better than things that just make you complicated. This is an 11nch grill pan that has increased durability due to the anodized aluminum.
The surface of the grill pan comes with standard grill marks that give you the grilling texture to your food and not to mention that it also helps you in helping your food being cooked properly. On each sides of the pan, there are spouts for pouring excessive oils and liquids that will help your food retain its healthiness.
The Anolon SureGrip handle ensures your safety when cooking plus giving you the space of giving you a stronger grip and is heat resistant up to 400 degree Fahrenheit. The Dupont nonstick coating helps you grill your food better. Because of the nonstick coating, your food won't be stuck as you grill and it also makes cleaning the grill pan easy.
The grill pan from Anolon is made with hard anodized aluminum which is a great combination as it is not only good for heat spread but also is light and has increased hardness.
This pan is of 11 inch which is above the standard size causing it to have enough space for you to grill big pieces of meat and veggies.
The pan comes with spouts on the sides for removing fatty oils to make your food much healthier.
The Anolon SureGrip allows you to get a strong grip that is comfortable which will help your performance in grilling and make it easy for you to cook.
This grill pan is coated with Dupont nonstick coating, creating a surface that won't destroy your food as you grill.
If sleek and slim are in your category, then the aluminum anodized pan from Calphalon might be just for you. This pan speaks volume when it comes to design. The luxury look with the brushed aluminum design caught you off guard and puts your thoughts on a positive note.
This pan is an interesting pan and it is because of its specifics. This is a Panini pan and is also a presser. While, the word 'Panini' can make you feel like this pan can't grill, you are wrong because it actually can. And if you can remember correctly, paninis' are grilled.
This pan being a presser is the most fascinating thing in our opinion because you actually use the lid of the pan to press it. While this pan might look lavish and fragile, it actually can take the heat and be used in a variety of ways. This pan can be used on the stove, inside of an oven etc. The pan has 3 layers of nonstick coating, making it easy for you to cook and clean. Also because of the nonstick coating, the oily fat is easily removable.
This pan is made with aluminum that has been anodized, which increases durability and has better retention when it comes to heat spread.
The lid of this grill pan also acts as a presser that can be handy from time to time.
The brushed aluminum look gives this grill pan a stylish and a premium look that bring pleasure to the eyes.
The grill pan is coated with 3 layers of nonstick which helps in grilling, cleaning and removing those fatty oils easily.
The brand can ring a bell in your ears and that is because we have reviewed some of their pans already. The idea that you hear the same name over and over again might mean that it must have something that people like.
This is another aluminum constructed grill pan that is hard anodized to make the pan more durable and increase sturdiness. The pan has a nonstick coated layer that is PFOA free which ensures that your food won't get contaminated as you grill and can have fun cooking using the nonstick feature.
This pan is of 12 inches sized, making it possible for you to grill meat pieces of meat or vegetables. The handle is of brushed stainless steel and is long which gives you enough space to get a good grip. This grill pan can be used on a gas stove or in an oven. Also the pan is dishwasher safe; hence you can easily clean your pan without any worries taking up your time.
This pan is constructed with aluminum that is hard anodized making it much stronger than before while holding the ability of evenly heat spread.
This is a 12inch sized pan, which means you have a lot of space to play and cook with.
This is a nonstick pan that is PFOA free. Because of that, no toxins will harm or contaminate your food as you grill away.
This pan is also dishwasher safe, making it easy for you to cleanup and not worry so much about spending time cleaning up.
We think that size is one of the most important factors when buying a grill pan. You really don't want to own a grill pan that is small when you're grilling for a party. Hence understanding what you need is important when buying.
Depending on the material that it has been used for making the grill pan is heavily related to its durability, usage and various features. So understanding the material is important and specially knowing of where you will be grilling. Depending on indoors, outdoors or perhaps both, different materials gives you different output.
Sometimes, you might get caught off-guard by seeing some feature that you might probably need but you are not sure. Because you don't want to have that regret feeling, it's best to have a clear mind of what you want when buying.
Whether grilling may have been an essential at one point of age, at this time, it's very crucial that we have some recreational time with ourselves and our close friends and families. And there is nothing better than having a backyard BBQ party or just grilling some sweet potatoes up so that you can have a good time with some great food and friends.
And because of that reason we have searched and picked some of the best grill pans for you so that you can understand your wants but know a bit more than before, so that your grilling can be even more better than before. We hope you have read our article and have helped and will help you in choosing the perfect pan for you situation. We cannot wait to see you start grilling and start connecting with your friends and families like how you grill some soul food.


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Truckee Tahoe community announcements
Sun staff report
Content for briefs is selected from e-mail submissions to Community Editor Amy Edgett at aedgett@sierrasun.com and occasionally the online events calendar. Visit http://www.sierrasun.com to submit events online. Please limit descriptions to 50 words. E-mail submissions may be 150-300 words. Items published in the print edition news space permitting.
Excitement is growing about a downtown streetscape project scheduled to break ground next week in Truckee. The town is partnering with two private property owners to build new sidewalks and landscaping at the intersection of Donner Pass Road and Bridge Street andamp;#8212; a key downtown location. The goal is to have full access restored to all businesses in the project vicinity prior to July 4.This project will be constructed to the west of the recent sidewalk improvements along the frontage of the Carmel Gallery and the Truckee Hotel. It will dramatically improve the frontage of the Bar of America and the Truckee Hotel. The improvements will include wider sidewalks and high-quality streetscape amenities, including landscaping, street furniture and lighting.Updates on the project will be posted at http://www.townoftruckee.com. Contact Mike Vaughan, senior engineer at 530-582-2923 or e-mail mvaughan@townoftruckee.com.
The North Tahoe High School Jazz Ensemble is holding a New Orleans Jazz Performance Wednesday, May 18 at 7 p.m. in the North Tahoe High School Theater.Tickets are available directly from Jazz Ensemble students or The Store, 850 North Lake Blvd., Tahoe City. Prices are $10 for adults and $5 for students purchased in advance and $13 adults and $8 students at the door. Proceeds directly benefit the Jazz Ensemble Tour and generally all other North Tahoe High Jazz Ensemble activities.
Excellence in Education Foundation Golfing for Schools Cards are on sale. The transferable cards cost $400 and are valid for 18-holes of play at eight of North Tahoe and Truckee's premiere golf courses including: Coyote Moon, Northstar-at-Tahoe, Old Brockway, Old Greenwood, Resort at Squaw Creek, Tahoe City, Tahoe Donner and Gray's Crossing. Cards may be purchased at Porters Sports in Truckee and online at ExinEd.org. There is an eight card per person purchase limit and additional restrictions apply. Only a limited number of passes are available and cards will be sold on a first come, first serve basis. For more information call 530-550-7984 or visit http://www.ExinEd.org.
Lecture by David Antonucci, May 19. This presentation brings a broad introduction and overview of the important facts and unique history of Lake Tahoe to everyone. Hear about Tahoe's exceptional size, depth and clarity. Understand its long history as a supplier of lumber and water and as a recreational playground. Participants will have a greater understanding of the area, leading to a deeper appreciation and lasting memories of Lake Tahoe. Companion booklets are available for $5 each. Located at The Mark Twain Cultural Center, 760 Mays Blvd. Ste. 10, Incline Village, Nev. Doors open at 6 p.m., the show begins at 7 p.m. Bring your own dinner and beverage. Comfortable chairs and tables provided. Tickets are $10 adults; $8 seniors; $5 students. To purchase tickets please visit marktwainculturalcenter.org or call 775-831-2820.
Through the eyes of the Ghost of Mark Twain, McAvoy Layne, this saga begins with Nevadaandamp;#8217;s first millionaires and skips comically and panoramically across the remarkable characters and occasions that made Nevada, andamp;#8220;Americaandamp;#8217;s Playground,andamp;#8221; May 20. Bugsy, Harrah, Hughes, Frank and Marilyn, Lake Tahoe and the Cal-Neva Lodge, theyandamp;#8217;re all included in this entertaining production recounting Nevadaandamp;#8217;s romance with disrespect-ability at The Mark Twain Cultural Center, 760 Mays Blvd., Ste. 10, Incline Village. Doors open at 6 p.m., shows begin at 7 p.m. Bring your own dinner and beverage. Comfortable chairs and tables provided. Tickets: $24.99 adults; $19.99 seniors and $9.99 students at http://www.marktwainculturalcenter.org or 775-831-2820.
Sierra Senior Services and the Community Health Partnership would like to announce a one-day event for the Truckee and North Lake Tahoe community offering information useful for health aging in place from public service providers and private vendors. This event will also be combined with group discussions on topics such as legal issues, Medicare, medication interactions and what to do when you canandamp;#8217;t live alone.The goal is to promote healthy aging by connecting community members to appropriate services and providers. This opportunity will be held at the North Tahoe Events Center, 8318 N. Lake Blvd., Kings Beach, May 21, 10 a.m. – 2 p.m.If you are interested in promoting an agency or a service targeting adults over the age of 55 and their families you are invited to participate by connecting with Sarah Deardorff at shdsierraseniors@sbcglobal.net or 530-550-7600.
West Shore and Tahoe City homeowners face unique challenges in maintaining homes and properties. This yearandamp;#8217;s record winter has been particularly damaging to roofs, decks, siding and windows. Landscape and trees have also suffered from the long winter. Granlibakken Resort is hosting an event offering opportunities for year round and second home owners who face maintenance challenges. This is an opportunity to meet contractors and material suppliers representing multiple trades. Their focus will be on Tahoe City and West Shore specific homeowner needs, Saturday, May 28, noon-5 p.m. with wine, beer, soft drinks and appetizers 3-5 p.m. No entry fee but vendor/contractor registration required. Sponsorship opportunities are available. Contact Kay Williams at Granlibakken Resort, 530-581-7307 or Kaywilliams@granlibakken.com.


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Dark and Darker: Best Classes Tier List
Crawling dungeons is a dangerous business, you'll want to know the best classes to survive in Dark and Darker.
There are six main classes in Dark and Darker, which is currently not running a beta or alpha but will be back in February. Each class has access to perks and skills that can significantly improve their stats and overall performance, making the gameplay much more exciting.
Our guide will provide you with a tier list of the best classes in Dark and Darker, including their best perks and abilities.
S-Tier Classes
Image via IRONMACE
Strength: 13
An ability to heal oneself and others plays a significant role in Dark and Darker, and that's why Cleric can easily be considered the most important class in the game. And it can resurrect other players!
It is a perfect class for both beginners and experienced players, who like to play in a position of a support class. And if you like to have a wide choice of armor and shields, then Cleric's got it all.
Its best perk is Undead Slaying, which boosts all your damage against undead by 20%, and his best skill is Undead Purification, which functions like an AoE against the undead.
Ranged damage allows players to deal with enemies at a distance, and thus protect yourself from receiving damage. That's where Ranger becomes very valuable, especially since it can shoot through holes in doors.
The Ranger's best perk is Tracking, which allows you to detect enemy footsteps, and its best skill is Multishot, which allows you to shoot five targets at once. Ranger can also heal himself by foraging food or by setting up a campfire.
A-Tier Classes
Casting spells is a great alternative to dealing ranged physical damage, although there are a few drawbacks to this class in comparison to Ranger or Cleric.
Wizard's best skill is Meditation, which allows it to immediately restore his spells. This is the only class in the game with this kind of ability.
Although Wizard can be very effective against enemies with heavy armor, its own strength and health are very low. It can be very hard to survive without Cleric in your party.
If you're tired of slow, clumsy characters, then Rogue should be your number one choice due to its high mobility and agility.
One of the Rogue's best perks is Lockpick Expert, which provides you with an unlimited amount of lockpicks. Another great perk is Poisoned Weapon, which allows you to detect and disarm traps. Rogue's best skill is Hide, which basically makes him invisible.
Rogue is a great class, although you may find that the damage is a bit lacking and it has no access to spells.
B-Tier Classes
Fighter has access to a vast selection of both weapons and armor, which allows you to achieve balance and flexibility.
Its Dual Wield perk allows you equip a weapon in each hand, thus increasing his damage output. Alternatively you can wield a shield for increased defense.
Fighter is also one of the few classes who has the ability to heal himself, using his Second Wind skill. But this class can be effective only against melee enemies, and it is highly vulnerable against magic.
Barbarian has the most strength and health of all other classes in Dark and Darker, but that's all he's got.
The Barbarian's two best perks are probably Iron Will, which protects it from magic damage, and Smash, which allows him to break doors. Its best skill is War Cry, which increases his own HP, as well as of his allies.
But other than that, Barbarian is a very slow class with no ability to cast spells and no significant buffs. This class will survive only in a well built team.
Those are the best classes in Dark and Darker, and stay tuned for more Dark and Darker guides when the game opens back up.
Featured image via IRONMACE
Serhii Patskan
Sergey has been a freelancer in the video games industry for more than five years, writing for various publications around the world. His favorite games are MtG, Dark Souls, Diablo, and Divinity: Original Sin.
Games Dark and Darker Genres Free to PlayRPG Platforms PC Tags dark and darker guides
Published Dec. 26th 2022
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Fares and Passes – E.P.T.A.
EPTA's fares are easy to calculate. We charge a flat rate of $2.00 for each trip, plus 50 cents for travel between zones. We also have half-price fares available to passengers with disabilities. Please complete the Half-fare application and the Medical Professional application.
Note: Shepherd University students with a valid Student ID can ride the Shepherd University Circulator free of charge.
Eastern Panhandle Transit Authority now accepts Visa, Master Card, Discover and American Express credit cards. Our passengers are able to call our office at 304-263-0876 and purchase their passes over the phone or process the passes through our website. The different options are: Monthly Passes, which can be purchased for $60.00, $10.00 punch Cards, $2.50 or 1.00 tickets. Currently passes will be mailed, or distributed to bus drivers on designated routes (credit card payments must be made before 3 pm to have pass available next day on bus). With each transaction there is a processing fee, all transactions are processed through WViPay.com, to purchase passes CLICK HERE.
EPTA now offers "Token Transit Mobile Ticketing" will be available in our service area. Purchase monthly passes, one way trips, and multiple ride passes. Token transit is a mobile ticketing platform for transit agencies across the US. Download the Token Transit app for iOS and Android phones. Simply text "Token" to 41411 to download your link to mobile ticketing. The first purchase will be 50% off!
It costs $2.00 to get on a bus. If you travel between zones, for instance, from The VA Hospital in Zone 2 to the Caperton Train Station in Zone 1, the cost increases by $0.50. Add $0.50 every time you cross a zone.


Working late and can't practice tonight!
Bring your Yogeasy hands to work for some pushups while your client is processing! They are so easy to use on any surface, and they are non-slip!
Yogeasy Hands will debut at The Yoga Expo Ft. Lauderdale!
Welcome to the World of Yogeasy!


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Tranquebar- the land of singing waves
by Charukesi Ramadurai (Lonely Planet Author) Jul 2018
Dansborg Fort in Tranquebar
Image courtesy: ©Charukesi Ramadurai
There are many ways to enjoy the monsoon season. My favourite is to sit on an armchair on an open verandah with a cup of masala chai, listening to the pitter patter of raindrops falling on the roof. And if you add to it the music of giant sea waves crashing against rocks on the shore, then I consider that experience unmatched.
That perfectly describes my weekend not long ago in Tranquebar, on the southern Coromandel coast of India. I was staying in a spacious room on the upper level of The Bungalow on the Beach, a boutique heritage property managed by Neemrana Hotels.
Tranquebar is one of the rare European settlements in India that does not owe its existence to the British or the Portuguese. It was established by Danish explorers in the early 17th century as a trading port after a treaty with local ruler Raghunatha Nayak. The Danes traded and ruled from here till 1845, when the British took charge.
Also Read: Best boutique stays for a coffee filled experience in Coorg
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The town has a quiet setting
Today, it is a quiet and charming village, with only a few local attractions- perfect for those who seek a break from the stress of everyday life and work. The highlight here is the sprawling Dansborg Fort right on the shore, which used to be the hub of all commercial and administrative activity under the Danes. This fort was one of the first things built by the European traders when they found their way to Tranquebar.
The Dansborg fort was visible from my cozy perch on the hotel verandah, as was the colourful Masilamani Nathar temple on the other side. This Shiva temple, believed to have been built in 1306 by Kulasekara Pandiyan, predates almost every building in town. After it was damaged in the tsunami of 2004, the façade of this temple (originally built in classic Tamil architecture style), was painted in bright colours, as part of the repair process.
The town gate
When the rain let up, I headed out for an exploratory walk of Tranquebar, starting at the very entrance to the town. This is marked by the imposing Landporten (town gate) arch that greets visitors to this town, and has an etching of the royal Danish insignia on top. On the narrow lanes of the town, with grand names like King's Street and Goldsmith Street, there are also several colonial era churches, schools and even a building that housed India's first printing press.
The 2004 tsunami that ravaged this town, claiming the lives of over 800 residents, is still fresh in the minds of its people. On Queen's Street in the heart of town, there is even a museum dedicated to the tsunami, displaying images and videos of its aftermath. As I walked around the tiny rooms, taking in the terrible scenes, I could only marvel at how the town has bounced back in just over a decade.
The only sign that the locals now fear the sea is visible on the boats lined up on the beach. Large images of benevolent gods who will protect fishermen from the wrath of nature are painted on both sides of these boats. Other than that, everyone was warm and welcoming, the beach filled with families, young couples and frolicking children in the evenings.
Thick canopies in the mangroves of Pichavaram
After a couple of restful days in Tranquebar, we drove on to Pichavaram, for a look at the second largest mangroves system in India after the Sunderbans. A rowboat was hired for a quick tour of the mangroves. Spread over 3000 acres, Pichavaram has a complex labyrinth of 4400 narrow canals eventually merging into the Bay of Bengal.
Along the way, our boatman pointed out local birdlife- 200 species have been identified here- and a narrative about the stunning ecosystem of these waters. The boat ride took us through some stretches where the trees have formed thick canopies, which means there is little sunlight reaching the water, and we had to duck our heads to prevent getting hit.
Sitting back and enjoying this experience is a unique feeling in itself.


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Ireneo Aleandri (ur. 8 kwietnia 1795 w San Severino Marche, zm. 6 marca 1885 w Maceracie) – włoski architekt i budowniczy.

Biografia
Ireneo Aleandri urodził się w San Severino Marche 8 kwietnia 1795 roku. Studiował w rzymskiej Akademii Świętego Łukasza. Był uczniem Raffaela Sterna i Giuseppe Camporesego. Po powrocie do Marchii w 1819 roku został inżynierem miejskim w San Severino. W 1823 roku zlecono mu zaprojektowanie teatru na otwartym powietrzu w Maceracie. Amfitear () został ukończony w 1829 roku. Aleandri prowadził wiele prac budowlanych na terenie Marchii i Umbrii. Został architektem kard. Giovanniego Antonia Benvenutiego, ordynariusza Osimo. Architektowi powierzono kwestie budowlane Spoleto i całej prowincji.

W projektowaniu Aleandri starał się odpowiadać na praktyczne potrzeby obywateli, wzorując się na architektach XV i początku XVI wieku. Ireneo Aleandri zmarł w Maceracie 6 marca 1885 roku.

Ważniejsze projekty
Ważniejszymi budowalami zaprojektowanymi przez Ireneo Aleandriego były:
 1823–1829 – Sferisterio w Maceracie
 1823 – teatr w San Severino
 1841–1846 – teatr w Ascoli Piceno
 1846–1853 – wiadukt łączący Albano z Ariccią
 1854–1864 – teatr w Spoleto
 1854–1864 – dzwonnica i renowacja fasady kolegiaty w Otricoli
 1854–1864 – fasada ratusza w Foligno

Przypisy

Włoscy architekci
Urodzeni w 1795
Zmarli w 1885

redpajama_set_name: RedPajamaWikipedia


Threaded Inserts provide metal threads stronger than what could be tapped directly into the plastic material. In some cases, these inserts are provide with a thru-hole (un-threaded) which can serve as a compression limiter or a strong surface area to prevent wear of the plastic. These parts are retained in the plastic using knurls, undercuts,barbs, and/or hex configurations. Strategic Source Components offers a wide variety of threaded inserts designed for molded, ultrasonic/thermal, and post molded applications.
Ultrasonic/Thermal Inserts are designed to be installed into thermoplastic materials with use of an ultrasonic or thermal insertion machine. An ultrasonic machine will generate high frequency vibrations that create frictional heat allowing the plastic to slightly melt and flow into knurls and undercuts. Thermal Installation machines apply direct heat to the insert that will cause the plastic in the hole to slightly melt and flow into knurls and undercuts. These methods provide excellent pull-out/jack-out performance in thermoplastic materials. These inserts are provided in straight hole (Series 100) and tapered hole (Series 200) varieties. The advantages of ultrasonic/thermal installation include rapid installation, elimination of potential mold damage, and increased productivity due to improved mold cycle times. The disadvantages include cost of ultrasonic/thermal installation equipment, limited to thermoplastic materials (not suitable for thermoset materials), and settings may need to be adjusted for insert size and thermoplastic type.
Please click on the links to see the styles of ultrasonic/thermal inserts we offer.
Mold In style inserts are designed to be installed into plastic materials by using core pins during the molding process. These inserts usually have either a diamond knurl with undercuts and come in both blind (Series 300) and thru hole (Series 350) varieties. The advantages of mold in style inserts include: no additional installation equipment required, a wider variety of insert configurations, and excellent pull-out/jack-out performance in both thermoplastic and thermoset materials. The disadvantages to this method include slower molding cycle times as the process has to wait for an operator to load onto a pin, operator safety, and potential mold damage should an insert fall off during the molding operation.
Please click on the links to see the styles of standard mold in inserts we offer.
Press Fit Inserts are installed into molded or drilled holes without the use of heat using a slow action press. These inserts normally have a hex configuration with barbs (Series 400) or a milled slot with knurling (Series 500,510, & 520). The advantages of press fit inserts include: quick/simple installation (arbor press), no heat or ultrasonics required, designs available for both thermoplastic and thermoset materials, and good pull-out/jack-out performance. The disadvantages to these products are less performance than other methods (mold-in/ultrasonic/thermal) and larger boss diameters needed due to higher installation stress.
Please click on the links to see the styles of press fit inserts we offer.


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City Council Considers Tax Increment Financing to Boost Downtown, Badgerow Building
Published November 18, 2019 at 12:27 PM CST
111819 noon
The Sioux City Council will be asked today to approve a resolution that a maximum of $1 million in funds be committed to the Badgerow Building and another $1.6 million to two other projects in the city's Historic Fourth Street District.
The council will consider adopting an amendment to the Combined Central Sioux City -- CBD Urban Renewal Area Plan.
In October the council approved a measure to allow the city to purchase the historic Badgerow Building for $750,000 from Cedar Rapids Bank and Trust Company so that it can be used for the continued redevelopment of downtown.
City documents say, no more than $1 million in tax-increment financing, or TIF, funds would be committed to the Badgerow Building.
Iowa Supreme Court Chief Justice, Mark Cady, courtesy AP
The life of Iowa Supreme Court Chief Justice Mark Cady will be commemorated at a public service on the Drake University campus at 10:00 Wednesday morning.
Cady's family on Friday evening announced the death of the 66-year-old chief justice following a heart attack. He was residing in Fort Dodge at the time of his death.
President Donald Trump enjoys widespread popularity among registered Republicans in Iowa, the first state that will cast preference votes in the 2020 presidential race, a new Iowa Poll shows.
The president's popularity has never been higher among registered Republicans who don't plan to attend the Democratic caucuses, the Des Moines Register/CNN/Mediacom Iowa Poll found.
His overall job approval is up 4 percentage points in March to 85 percent. The percentage of those who say they will definitely vote to re-elect him is up 9 percentage points to 76 percent.
Local News LocalSioux City CouncilBadgerow Buildingnews2020 Presidential CaucusesUS President Donald TrumpIowa State Supreme Court Chief Justice Mark CadyTax Increment FinancingIowa Poll
Mary Hartnett
See stories by Mary Hartnett
Veterans Day in Sioux City, Sen. Klobuchar Visits NW Iowa
111119 304Today is veterans day and vets, city and county officials met this morning at the Woodbury County Courthouse to pay tribute. Mary Jordan is the…
US Senator and Presidential Candidate Amy Klobuchar Visits Sioux City, Vets Remembered
111119 5 04Democratic Presidential Amy Klobuchar campaigned in northwest Iowa this weekend.On Saturday morning, the US Senator from Minnesota joined a…
Dr. Jill Bident Meets Potential Caucus-Goers in SIouxland
Eight months after flooding began along the lower Missouri River, the amount of water being released from dams upriver will start to be reduced later this…


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Category: International Women Leaders
Kinga Wisniewska on Collaboration over Competition
Editor's Note: This interview in our Feminist Giving IRL series features Kinga Wisniewska, the Resource Mobilization Manager at FRIDA | The Young Feminist Fund, a youth-led feminist fund working to support grassroots organizers in over 120 countries in the Global South.
Kinga Wisniewska is a feminist and a sexual and reproductive health and rights activist from Warsaw, Poland, now serving as the Resource Mobilization Manager at FRIDA | The Young Feminist Fund. (Image Credit: FRIDA | The Young Feminist Fund)
1. What do you wish you had known when you started out in your profession?
The fundraising field is quite secretive, as organizations fear that sharing their donor experiences would have repercussions on their relationships, or that they would have to compete for funds if they disclosed what opportunities they are working on. It's so weighty to work in silos, feel isolated and overwhelmed with the "I have to do it all on my own" mentality. That makes fundraising burnout very real, with lasting effects on our well-being and health, and affects so many of us in philanthropy, especially those working in resource mobilization.
Author Maggie MayPosted on August 26, 2020 August 26, 2020 Categories Activism, Civil Society, Community Foundations, Feminist Foundations, Feminist Philanthropy, Feminist Strategy, Foundation Leaders, Gender Lens Grantmaking, Gender Lens Investing, Global Philanthropy, International Women Leaders, Nonprofit Women Leaders, Philanthropy Women, Sustainable Development Goals, Women Leaders, Women's FundsTags Feminist Giving IRLLeave a comment on Kinga Wisniewska on Collaboration over Competition
Kamala Harris: "We're Gonna Get It Done."
"We're gonna get it done." These were some of the first words spoken by Vice Presidential Candidate Kamala Harris in her phenomenal half-hour interview with Errin Haines, Editor-at-Large for the 19th, during the 19th Represents Summit on Friday. Harris's plans to "get it done" refer to the upcoming Presidential election, and her goal to join Joe Biden in leading the U.S. out of one of its worst crisis periods in history.
Vice Presidential candidate Kamala Harris spoke with Errin Haines of The 19th on Friday, August 14th, giving details of her experience becoming the first woman of color nominated to the U.S. Presidential ticket. (Image Credit: The 19th video, Youtube)
Haines began the interview by asking what it was like for Kamala Harris to be in competition with women she respected and worked with, other candidates who were running for President and were in the lead to be asked to fill Biden's ticket for the Vice President spot.
Author Kiersten MarekPosted on August 18, 2020 August 18, 2020 Categories Events, Feminist Strategy, Health Care, Human Rights, International Women Leaders, Male Allies, Political Struggle, Reproductive Rights, Unions, Women and Girls of Color, Women Leaders, Women Speak, Women's Health, Workforce DevelopmentLeave a comment on Kamala Harris: "We're Gonna Get It Done."
Announcing the Winners of the About Women Art Contest
As a writer and publisher, I was excited to recently rediscover my passionate interest in creating and supporting visual art. The pandemic has had many terrible impacts on our lives, but one positive impact it had for me was getting me more engaged in my own love for art. During the extended times many of us have been spending socially distancing, I began to paint, first doing portraits of African Americans, and then moving on to still life paintings and impressionistic landscapes.
Street Vendor by Eva Lechner is our Third Place Winner in the About Women art contest.
In an effort to support women and LGBT+ artists, we launched our first art contest recently. The theme for the contest was "About Women" and we received more than 100 entries of some stunning and moving visual art pieces. There were 185 votes on the entries, and the winners were chosen by public vote, so popularity was more of a factor, as opposed to a contest that is judged by a jury of artists.
Author Kiersten MarekPosted on August 17, 2020 August 17, 2020 Categories Arts funding, Events, Feminist Strategy, International Women Leaders, Women and Girls of Color, Women ArtistsLeave a comment on Announcing the Winners of the About Women Art Contest
What Kamala Harris Represents for Donor Activism and Inclusion
Kamala Harris has officially made history.
The landmark selection of Harris as Joe Biden's running mate in the 2020 election represents a huge win for diversity in politics. What's more, Harris represents the positive impact of campaigning, fundraising, and donating in the world of feminist philanthropy.
What does the selection of Kamala Harris say about the future of feminist funding? And what does it represent for how far we've come? (Image Credit: Joe Biden, Twitter)
Harris's own presidential campaign says a lot about what we can do with feminist funding for political campaigns. Her decision to eschew funding from PAcs likely played a major role in her eventual drop from the 2020 race, but her commitment to funding sources outside the norm of American political campaign speaks to just how far we can go with feminist funding.
Author Maggie MayPosted on August 14, 2020 August 14, 2020 Categories Activism, Feminist Philanthropy, Feminist Strategy, Foundation Leaders, International Women Leaders, Male Allies, Philanthropy Women, Political Struggle, Women and Girls of Color, Women in Business, Women LeadersLeave a comment on What Kamala Harris Represents for Donor Activism and Inclusion
Survivor Leadership to End Human Trafficking — Liveblog
The anti-trafficking movement is one of the most important movements for women's equality, since a large proportion of survivors of trafficking are women. But often, the voices of the actual survivors of trafficking get excluded from approaches to solving this problem.
Webinar speakers for How Anti-Trafficking Funders Can Support Survivor Leadership included Amy Rahe (moderator), Claire Falconer, and Natasha Dolby.
Recently, the Freedom Fund hosted a webinar to discuss ways that funders can work to include survivors in leadership. Amy Rahe, interim director of the Freedom Fund, moderated the discussion. Guest speakers included Mahendra Pandey, Senior Manager, Forced Labor & Human Trafficking for Humanity United, Natasha Dolby, Co-Founder, Freedom Forward, and Claire Falconer, Head of Global Initiatives and Movement Building, The Freedom Fund.
Author Kiersten MarekPosted on August 11, 2020 August 11, 2020 Categories Events, Feminist Philanthropy, Feminist Strategy, Gender Lens Grantmaking, International Women Leaders, Nonprofit Women Leaders, Sustainable Development Goals, Women Leaders, Women's HealthLeave a comment on Survivor Leadership to End Human Trafficking — Liveblog
Liveblog – What Donors Can Do About Lack of Funding for Women and Girls of Color
Today marks our third webinar at Philanthropy Women! On Thursday, July 23rd, we gathered for "Lack of Funding for Women and Girls of Color: What Donors Can Do."
We kicked off our third webinar with a warm welcome to our participants. Kiersten Marek, Editor-in-Chief, began with an overview of the funding issues outlined in Pocket Change, the Ms. Foundation's report on the funding gap for women and girls of color.
Kiersten pointed out other issues impacting the funding environment for women and girls of color, including the recent announcement of downsizing at the NoVo Foundation, and the potential for funds being redirected to address the COVID crisis. However, there is some encouraging action happening now, as new corporations and foundations have stepped up for intersectional giving.
Author Maggie MayPosted on July 23, 2020 July 23, 2020 Categories Activism, Events, Feminist Foundations, Feminist Philanthropy, Feminist Strategy, Foundation Leaders, International Women Leaders, Nonprofit Women Leaders, Women and Girls of Color, Women Leaders, Women Speak, Women's FundsLeave a comment on Liveblog – What Donors Can Do About Lack of Funding for Women and Girls of Color
What Melinda Gates Says, and Doesn't Say, About Women in COVID
"Architects of a better world" is how Melinda Gates frames the role of women in the age of COVID. In a recent article in Foreign Affairs, the co-founder of the world's largest philanthropic organization makes the case that women's leadership is the beacon of light the world needs most right now.
Gates starts off the essay by recognizing the silent pandemic of violence against women happening during COVID. She goes on to detail in full the many ways that women are losing access to health care and jobs, all while being piled with more housework and childcare duties.
(Image Credit: Oladimeji Odunsi at Unsplash)
Maternity Care Needs to Develop Workarounds for COVID
Gates is particularly worried about expectant moms in COVID, and with good reason. She relates some of the staggering losses suffered in the Ebola outbreak of 2014 in Sierra Leone. One suggestion that Gates makes for COVID: separate facilities for COVID and non-COVID pregnant women in some countries so that women can still get maternal care, even if they are COVID positive.
Author Kiersten MarekPosted on July 21, 2020 July 21, 2020 Categories Activism, Civil Society, COVID, Feminist Foundations, Feminist Philanthropy, Feminist Strategy, Foundation Leaders, Gender Lens Grantmaking, Gender-based Violence, Global Philanthropy, Health Care, International Women LeadersLeave a comment on What Melinda Gates Says, and Doesn't Say, About Women in COVID
Beyoncé: "Vote like our life depends on it, because it does."
"We have to vote like our life depends on it, because it does," said Beyoncé in her pre-recorded acceptance speech for the 2020 BET Awards. The performer and philanthropist is 2020's recipient of the Humanitarian Award, bestowed for her work through the BeyGOOD Initiative and other campaigns.
International superstar Beyoncé is the recipient of the 2020 BET Humanitarian Award. (Image Credit: BET/Twitter)
"Thank you so much for this beautiful honor," she said. "I want to dedicate this award to all of my brothers out there, all of my sisters out there inspiring me, marching and fighting for change. Your voices are being heard and you're proving to our ancestors that their struggles were not in vain."
Author Maggie MayPosted on July 12, 2020 July 12, 2020 Categories Activism, COVID, Events, Fashion, Feminist Foundations, Feminist Philanthropy, Feminist Strategy, Global Philanthropy, Human Rights, International Women Leaders, Most Powerful Women in Philanthropy, Political Struggle, Women and Girls of Color, Women in Business, Women Leaders, Women SpeakLeave a comment on Beyoncé: "Vote like our life depends on it, because it does."
Emma Watson Among New Kering Foundation Board Members
Kering's shareholders have approved the appointment of Ms. Jean Liu, Mr. Tidjane Thiam and Ms. Emma Watson as Directors during their Annual General Meeting on June 16th, as proposed by the Board of Directors gathered on March 12th, 2020.
Emma Watson (Photo Credit: Kering Foundation)
Ms. Watson has also been appointed Chair of the Sustainability Committee of the Board of Directors, while Mr. Thiam was appointed Chair of the Audit Committee.
The combined wealth of experience and skillsets of these three well-known figures will be a complementary asset to the Group, enhancing the quality of the work done by the Board of Directors. The latter will benefit from their contribution in defining the Group's strategic orientations.
Author In The NewsPosted on June 29, 2020 June 29, 2020 Categories Climate Change, Corporate Giving, Events, Feminist Foundations, Feminist Philanthropy, Feminist Strategy, Gender Lens Grantmaking, Gender-based Violence, International Women Leaders, Women Leaders1 Comment on Emma Watson Among New Kering Foundation Board Members
Liveblog: Funding to End Violence Against Women of Color
Kiersten Marek, editor and publisher of Philanthropy Women, opened up today's webinar, "Funding to End Violence Against Women of Color," with a welcome to the speakers and audience.
She introduced the webinar with a discussion on the idea behind Philanthropy Women. Partially inspired by NoVo Foundation's bold commitment of $90 million in funding for women and girls of color in 2016, Philanthropy Women launched in January of 2017 to cover this kind of intersectional feminist giving approach and others like it. However, with NoVo's recent shuttering of programs for women and girls of color, the funding landscape for addressing domestic violence against women of color is facing some big changes.
Author Maggie MayPosted on June 25, 2020 July 3, 2020 Categories Activism, Community Foundations, COVID, Events, Feminist Foundations, Feminist Philanthropy, Feminist Strategy, Foundation Leaders, Gender Lens Grantmaking, Gender Lens Investing, Gender-based Violence, Health Care, Human Rights, International Women Leaders, LGBTQ, Philanthropy Women, Sustainable Development Goals, Women and Girls of Color, Women in Business, Women Leaders, Women's HealthLeave a comment on Liveblog: Funding to End Violence Against Women of Color


The AIChE Board of Directors has created a Membership Gift Program where active members of AIChE can give the gift of membership to a deserving engineer, at a special price of only $49.
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Ralph G. Dacey Jr., MD, the Henry G. & Edith R. Schwartz Professor and head of the Department of Neurosurgery at Washington University School of Medicine in St. Louis, has received the Distinguished Service Award from the Society of Neurological Surgeons. He received the award in May at the organization's annual meeting, which was in Houston.
The award recognizes his decades of service to neurosurgical education. Since joining the School of Medicine's faculty in 1989, Dacey has recruited and educated more than 50 neurosurgery residents.
Dacey, who is also neurosurgeon-in-chief at Barnes-Jewish Hospital, helps diagnose and treat cerebral aneurysms, brain tumors and malformations in the blood vessels in the brain. He and his team use innovative techniques and tools to minimize damage to the brain and nerves during surgery.


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daryavranawat@gmail.com
Jaipur Tourism
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Rajasthan Park Sanctuary
Ranthambore Tiger Reserve
Ranthambore Tiger Reserve lies on the junction of Aravali and Vindhyas just 14 Kms from Sawai Madhopur in Eastern Rajasthan. It is situated in the Sawai Madhopur district of southeastern Rajasthan, about 110 km northeast of Kota and 160 km southeast of Jaipur. The Rivers Chambal in the South and the Banas in the North bound the National Park. The park is dotted with steep rocky hills and the dominating architecture of Ranthambhor Fort (built in the 10th century), adds to its landscape. Other major wild animals include leopard, nilgai, wild boar, sambar, hyena, sloth bear and chital.
Sariska Tiger Reserve is an Indian national park and wildlife refuge located in the Alwar district of the state of Rajasthan. Sariska Tiger Reserve is situated only 200 km from Delhi and 107 kms from Jaipur. The most attractive feature of this reserve has always been its Bengal Tigers. It is the first tiger reserve in the world to have successfully relocated tigers. the reserve includes many species of wild life, such as the leopard, jungle cat, caracal, striped hyena, golden jackal, chital, sambhar, nilgai, chinkara, four-horned antelope, wild boar, hare, hanuman langur, Rhesus monkeys.
Tal Chapper Sanctuary
The Tal Chapper sanctuary lies in the Sujangarh Tehsil of Churu District, Situated in the North-East part of Rajasthan. It lies on Nokha- Sujangarh state Highway and is situated at a distance of 85 KM from Churu & about 132 Km from Bikaner. The nearest Railway station is Chapper which lies on Degana – Churu – Rewari metre gauge line of Northen Western Railways.
Darrah Sanctuary
An erstwhile royal hunting preserve of the Maharaja of Kota Rajasthan,The animals here include Wolf, Sloth Bear, Chinkara and Leopard.
Sajjangarh Sanctuary
Sajjangarh Wildlife Sanctuary, which encircles the palace, was established in 1987. It covers an area of 5.19 square kilometres .Sajjangarh Wildlife Sanctuary is situated 5kms in the West of tourist city Udaipur,Rajasthan The palace overlooks the sanctuary, which is a reserve for reptiles, tigers, nilgai, sambhar, wild boars, hyenas, panthers, and jackals.
Kumbhalgarh Sanctuary
Kumbhalgarh Wildlife Sanctuary is in the Rajsamand District of Rajasthan state in western India and surrounds the Kumbhalgarh fortress and covers an area of 578 km2 (223 sq mi). The sanctuary extends across the Aravalli Range, covering parts of Rajsamand, Udaipur, and Pali districts. The wild life includes wolf, leopards, sloth bear, hyena, jackal, jungle cat, sambhar, nilgai, chausingha (the four horned antelope), chinkara and hare. The bird life at Kumbhalgarh is also gratifying.
Desert National Park
The Sudashri forest post is the most ideal place for observing wildlife in the Desert National Park. Its include the blackbuck, chinkara, wolf, Indian fox, desert fox, hare and desert cat.
Mount Abu Sanctuary
Mount Abu Wildlife Sanctuary is located in one of the oldest mountain ranges of India, the Aravalli range. It was declared a wildlife sanctuary in 1980.
SitaMata Sanctuary
In forest of bamboo and dry deciduous vegetation.108 km from Udaipur, the forested Sanctuary provides rich pastures for a variety of Deer that includes the Chousingha and for Caracal wild Boar, Pangolin and Leopards.
Keoladeo Ghana National Park
The Keoladeo National Park or Keoladeo Ghana National Park formerly known as the Bharatpur Bird Sanctuary in Bharatpur, Rajasthan. The Sanctuary is one of the richest bird areas in the world. It is known for nesting of its resident birds and visiting migratory birds including water birds. The park was a hunting ground for the maharajas of Bharatpur.
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A level of distress or anxiety after a cancer diagnosis is not unexpected, but if not managed may lead to an anxiety disorder. In this presentation, Jane Fletcher, Health Psychologist and Director of the Melbourne Psycho-Oncology Service at Cabrini Health, discusses a range of anxiety disorders and the impact they can have on the individual and family. She also talks about some simple strategies to keep anxiety under control.