text:
Sumbaspökuggla (Ninox rudolfi) är en fågel i familjen ugglor inom ordningen ugglefåglar.

Utbredning
Fågeln förekommer på ön Sumba (västra Små Sundaöarna).

Status
IUCN kategoriserar arten som nära hotad.

Namn
Fågelns vetenskapliga artnamn hedrar kronprins Rudolf av Österrike-Ungern (1858-1889).

Noter

Externa länkar

Ugglor
Endemiska fågelarter på Sumba
Fåglar i australiska regionen

redpajama_set_name: RedPajamaWikipedia


text:
So it's a resignation after 200 deaths – but thousands lost to wars around the globe are a different matter?
By Islam Religion Guardian Last updated Aug 15, 2020
Uneasy is the head that wears a crown. But the heads – and the crowns – come in all shapes and sizes. Take an electrical engineering professor with a PhD in computer engineering from Bath University and compare him with a lawyer with a BA in jurisprudence at Oxford, and a Yale history graduate who started his career in the oil business.
The first has just resigned from his job after the death of at least 210 innocent civilians. The second and third never thought of resigning after participating on false pretences in a war that ultimately caused the death of up to half a million innocent civilians. Indeed, both continue their lives today, as unapologetic as they are safe from prosecution.
So what makes responsibility so different for Hassan Diab and the likes of Tony Blair and George Bush Jr? Poor old Hassan knew little of the explosives that would destroy the lives of his people last week. Tony and George knew very well the explosive power they were to unleash when they invaded Iraq in 2003. The Lebanese prime minister will presumably return to his necessarily humble role as a Beirut academic. The UK prime minister and US president both wrote self-serving memoirs. Blair continues to dispense worldly advice to democrats and dictators for outrageously high rewards.
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redpajama_set_name: RedPajamaCommonCrawl


text:
<?php

/**
 * Doctrine_Pager
 *
 * @author      Guilherme Blanco <guilhermeblanco@hotmail.com>
 * @package     Doctrine
 * @subpackage  Pager
 * @license     http://www.opensource.org/licenses/lgpl-license.php LGPL
 * @version     $Revision$
 * @link        www.doctrine-project.org
 * @since       0.9
 */
class Doctrine_Pager
{
    /**
     * @var Doctrine_Query $_query      Doctrine_Query object related to the pager
     */
    protected $_query;

    /**
     * @var Doctrine_Query $_countQuery Doctrine_Query object related to the counter of pager
     */
    protected $_countQuery;

    /**
     * @var array $_countQueryParams    Hold the params to be used by Doctrine_Query counter object of pager
     */
    protected $_countQueryParams;

    /**
     * @var integer $_numResults        Number of results found
     */
    protected $_numResults;

    /**
     * @var integer $_maxPerPage        Maximum number of itens per page
     */
    protected $_maxPerPage;

    /**
     * @var integer $page               Current page
     */
    protected $_page;

    /**
     * @var integer $_lastPage          Last page (total of pages)
     */
    protected $_lastPage;

    /**
     * @var boolean $_executed          Pager was initialized (called "execute" at least once)
     */
    protected $_executed;

    /**
     * __construct
     *
     * @param mixed $query     Accepts either a Doctrine_Query object or a string
     *                        (which does the Doctrine_Query class creation).
     * @param int $page     Current page
     * @param int $maxPerPage     Maximum itens per page
     * @return void
     */
    public function __construct($query, $page, $maxPerPage = 0)
    {
        $this->_setExecuted(false);

        $this->_setQuery($query);
        $this->_setPage($page);

        $this->setMaxPerPage($maxPerPage);
    }

    /**
     * _initialize
     *
     * Initialize Pager object calculating number of results
     *
     * @param $params  Optional parameters to Doctrine_Query::execute
     * @return void
     */
    protected function _initialize($params = array())
    {
        // retrieve the number of items found
        $countQuery = $this->getCountQuery();
        $count = $countQuery->count($this->getCountQueryParams($params));

        $this->_setNumResults($count);
        $this->_setExecuted(true); // _adjustOffset relies of _executed equals true = getNumResults()

        $this->_adjustOffset();
    }

    /**
     * _adjustOffset
     *
     * Adjusts last page of Doctrine_Pager, offset and limit of Doctrine_Query associated
     *
     * @return void
     */
    protected function _adjustOffset()
    {
        // Define new total of pages
        $this->_setLastPage(
            max(1, ceil($this->getNumResults() / $this->getMaxPerPage()))
        );
        $offset = ($this->getPage() - 1) * $this->getMaxPerPage();

        // Assign new offset and limit to Doctrine_Query object
        $p = $this->getQuery();
        $p->offset($offset);
        $p->limit($this->getMaxPerPage());
    }

    /**
     * getExecuted
     *
     * Returns the check if Pager was already executed at least once
     *
     * @return boolen        Pager was executed
     */
    public function getExecuted()
    {
        return $this->_executed;
    }

    /**
     * _setExecuted
     *
     * Defines if Pager was already executed
     *
     * @param $executed       Pager was executed
     * @return void
     */
    protected function _setExecuted($executed)
    {
        $this->_executed = $executed;
    }

    /**
     * getRange
     *
     * Builds and return a Doctrine_Pager_Range_* based on arguments
     *
     * @param string $rangeStyle Pager Range style
     * @param array $options     Custom subclass implementation options.
     *                           Default is a blank array
     * @return Doctrine_Pager_Range Pager Range
     */
    public function getRange($rangeStyle, $options = array())
    {
        $class = 'Doctrine_Pager_Range_' . ucfirst($rangeStyle);

        return new $class($options, $this);
    }

    /**
     * getNumResults
     *
     * Returns the number of results found
     *
     * @return int        the number of results found
     */
    public function getNumResults()
    {
        if ($this->getExecuted()) {
            return $this->_numResults;
        }

        throw new Doctrine_Pager_Exception(
            'Cannot retrieve the number of results of a not yet executed Pager query'
        );
    }

    /**
     * _setNumResults
     *
     * Defines the number of total results on initial query
     *
     * @param $nb       Number of results found on initial query fetch
     * @return void
     */
    protected function _setNumResults($nb)
    {
        $this->_numResults = $nb;
    }

    /**
     * getFirstPage
     *
     * Returns the first page
     *
     * @return int        first page
     */
    public function getFirstPage()
    {
        return 1;
    }

    /**
     * getLastPage
     *
     * Returns the last page (total of pages)
     *
     * @return int        last page (total of pages)
     */
    public function getLastPage()
    {
        if ($this->getExecuted()) {
            return $this->_lastPage;
        }

        throw new Doctrine_Pager_Exception(
            'Cannot retrieve the last page number of a not yet executed Pager query'
        );
    }

    /**
     * _setLastPage
     *
     * Defines the last page (total of pages)
     *
     * @param $page       last page (total of pages)
     * @return void
     */
    protected function _setLastPage($page)
    {
        $this->_lastPage = $page;

        if ($this->getPage() > $page) {
            $this->_setPage($page);
        }
    }

    /**
     * getLastPage
     *
     * Returns the current page
     *
     * @return int        current page
     */
    public function getPage()
    {
        return $this->_page;
    }

    /**
     * getNextPage
     *
     * Returns the next page
     *
     * @return int        next page
     */
    public function getNextPage()
    {
        if ($this->getExecuted()) {
            return min($this->getPage() + 1, $this->getLastPage());
        }

        throw new Doctrine_Pager_Exception(
            'Cannot retrieve the last page number of a not yet executed Pager query'
        );
    }

    /**
     * getPreviousPage
     *
     * Returns the previous page
     *
     * @return int        previous page
     */
    public function getPreviousPage()
    {
        if ($this->getExecuted()) {
            return max($this->getPage() - 1, $this->getFirstPage());
        }

        throw new Doctrine_Pager_Exception(
            'Cannot retrieve the previous page number of a not yet executed Pager query'
        );
    }

    /**
     * getFirstIndice
     *
     * Return the first indice number for the current page
     *
     * @return int First indice number
     */
    public function getFirstIndice()
    {
        return ($this->getPage() - 1) * $this->getMaxPerPage() + 1;
    }

    /**
     * getLastIndice
     *
     * Return the last indice number for the current page
     *
     * @return int Last indice number
     */
    public function getLastIndice()
    {
        return min($this->getNumResults(), ($this->getPage() * $this->getMaxPerPage()));
    }

    /**
     * haveToPaginate
     *
     * Return true if it's necessary to paginate or false if not
     *
     * @return bool        true if it is necessary to paginate, false otherwise
     */
    public function haveToPaginate()
    {
        if ($this->getExecuted()) {
            return $this->getNumResults() > $this->getMaxPerPage();
        }

        throw new Doctrine_Pager_Exception(
            'Cannot know if it is necessary to paginate a not yet executed Pager query'
        );
    }

    /**
     * setPage
     *
     * Defines the current page and automatically adjust offset and limits
     *
     * @param $page       current page
     * @return void
     */
    public function setPage($page)
    {
        $this->_setPage($page);
        $this->_setExecuted(false);
    }

    /**
     * _setPage
     *
     * Defines the current page
     *
     * @param $page       current page
     * @return void
     */
    protected function _setPage($page)
    {
        $page = intval($page);
        $this->_page = ($page <= 0) ? 1 : $page;
    }

    /**
     * getLastPage
     *
     * Returns the maximum number of itens per page
     *
     * @return int        maximum number of itens per page
     */
    public function getMaxPerPage()
    {
        return $this->_maxPerPage;
    }

    /**
     * setMaxPerPage
     *
     * Defines the maximum number of itens per page and automatically adjust offset and limits
     *
     * @param $max       maximum number of itens per page
     * @return void
     */
    public function setMaxPerPage($max)
    {
        if ($max > 0) {
            $this->_maxPerPage = $max;
        } else if ($max == 0) {
            $this->_maxPerPage = 25;
        } else {
            $this->_maxPerPage = abs($max);
        }

        $this->_setExecuted(false);
    }

    /**
     * getResultsInPage
     *
     * Returns the number of itens in current page
     *
     * @return int    Number of itens in current page
     */
    public function getResultsInPage()
    {
        $page = $this->getPage();

        if ($page != $this->getLastPage()) {
            return $this->getMaxPerPage();
        }

        $offset = ($this->getPage() - 1) * $this->getMaxPerPage();

        return abs($this->getNumResults() - $offset);
    }

    /**
     * getQuery
     *
     * Returns the Doctrine_Query collector object related to the pager
     *
     * @return Doctrine_Query    Doctrine_Query object related to the pager
     */
    public function getQuery()
    {
        return $this->_query;
    }

    /**
     * _setQuery
     *
     * Defines the collector query to be used by pager
     *
     * @param Doctrine_Query     Accepts either a Doctrine_Query object or a string
     *                           (which does the Doctrine_Query class creation).
     * @return void
     */
    protected function _setQuery($query)
    {
        if (is_string($query)) {
            $query = Doctrine_Query::create()
                ->parseDqlQuery($query);
        }

        $this->_query = $query;
    }

    /**
     * getCountQuery
     *
     * Returns the Doctrine_Query object that is used to make the count results to pager
     *
     * @return Doctrine_Query     Doctrine_Query object related to the pager
     */
    public function getCountQuery()
    {
        return ($this->_countQuery !== null) ? $this->_countQuery : $this->_query;
    }

    /**
     * setCountQuery
     *
     * Defines the counter query to be used by pager
     *
     * @param Doctrine_Query  Accepts either a Doctrine_Query object or a string
     *                        (which does the Doctrine_Query class creation).
     * @param array           Optional params to be used by counter Doctrine_Query.
     *                        If not defined, the params passed to execute method will be used.
     * @return void
     */
    public function setCountQuery($query, $params = null)
    {
        if (is_string($query)) {
            $query = Doctrine_Query::create()
                ->parseDqlQuery($query);
        }

        $this->_countQuery = $query;

        $this->setCountQueryParams($params);

        $this->_setExecuted(false);
    }

    /**
     * getCountQueryParams
     *
     * Returns the params to be used by counter Doctrine_Query
     *
     * @return array     Doctrine_Query counter params
     */
    public function getCountQueryParams($defaultParams = array())
    {
        return ($this->_countQueryParams !== null) ? $this->_countQueryParams : $defaultParams;
    }

    /**
     * setCountQueryParams
     *
     * Defines the params to be used by counter Doctrine_Query
     *
     * @param array       Optional params to be used by counter Doctrine_Query.
     *                    If not defined, the params passed to execute method will be used.
     * @param boolean     Optional argument that append the query param instead of overriding the existent ones.
     * @return void
     */
    public function setCountQueryParams($params = array(), $append = false)
    {
        if ($append && is_array($this->_countQueryParams)) {
            $this->_countQueryParams = array_merge($this->_countQueryParams, $params);
        } else {
            if ($params !== null && !is_array($params)) {
                $params = array($params);
            }

            $this->_countQueryParams = $params;
        }

        $this->_setExecuted(false);
    }

    /**
     * execute
     *
     * Executes the query, populates the collection and then return it
     *
     * @param $params               Optional parameters to Doctrine_Query::execute
     * @param $hydrationMode        Hydration Mode of Doctrine_Query::execute returned ResultSet.
     * @return Doctrine_Collection  The root collection
     */
    public function execute($params = array(), $hydrationMode = null)
    {
        if ( !$this->getExecuted()) {
            $this->_initialize($params);
        }

        return $this->getQuery()->execute($params, $hydrationMode);
    }
}

redpajama_set_name: RedPajamaGithub


Facebook has finally bowed to pressure from the European Commission and consumer protection authorities to be more transparent over how it uses and finances its users' data for profiling and targeted advertising.
In an update to its terms of service, the company is to describe in detail which of Facebook's services to third parties are based on the use of consumers' data, how consumers can close their accounts and with what justification accounts may be disabled.
This is the result of discussions calling for the full disclosure of Facebook's business model in a clear and simple language, the Commission said.
Both Facebook and Airbnb were initially called on in February last year by the Commission – before the Cambridge Analytica scandal broke – to ensure their terms of service complied with European regulations. It told them to improve communication with users, so they have full knowledge of what is done with information gathered about them.
Facebook has until the end of June 2019 to implement the changes or face enforcement action and potential sanctions.
Isn't it time we developed our own version of GDPR?


text:
Join us for our exclusive events
Flirt With Us
For the past seven years the Bâoli group has played host to the sexiest and most notorious girls night out. The weekly celebration attracts some of the most elite partiers in the world, who come to enjoy a night of decadent dining and champagne toasting. Bâoli, famous for its over the top events and beautiful staff, has hosted some of the worlds hottest headliners and in-demand DJ's, featuring the likes of Bob Sinclair, David Guetta, and Armin Van Buuren to name a few.
My Boyfriend is Out of Town first began stirring up trouble on the French Riviera at Bâoli Cannes and made its debut at Bâoli Miami some years later. Since then, My Boyfriend is Out of Town has been hosted all over the globe in places such as Russia, London, and Switzerland.
CAREERS PRESS RESERVATIONS
Get in on the fun
©2017 Bâoli | Crafted by yours truly,
CAREERS PRESS
© 2016 Bâoli Miami.
Private Event Software powered by Tripleseat


Egg Council Guy is seen when Homer discovers a secret society, named the Stonecutters, with members who are his friends.
When Homer wanted to join the Stonecutters, Lenny and Carl informed him that the only way to join was to either be related to a member or save the life of a member. At that time Lenny was eating an egg salad sandwich which Homer grabbed out of his hands and stepped on. After he finished stomping the sandwich, Homer told Lenny that they had to let him in now, as Homer had just saved Lenny's life. He elaborated by saying that the cholesterol present in the eggs could have killed Lenny if he ate too many.
Lenny, irritated at having his lunch stepped on, told Homer that even though studies have shown eggs to be high in cholesterol, they did not contain enough to be dangerous. Homer then glared at Lenny and stated that "those Egg Council guys" had gotten to him too. Lenny nervously looked back and forth, telling Homer that wasn't true. The Egg Council guy then came out from behind a door and ran down the hall, making squeaking noises as it went.
The Egg Council guy was later seen at the Stonecutters headquarters, singing and drinking with everyone else.
Marge and Maggie drove past him.
This section is transcluded from The Simpsons: Tapped Out characters/Easter 2014. To edit it, please edit the transcluded page.
Modified on January 12, 2017, at 17:37.


It has been prescribed by a Doctor, is in the original packaging and with the pharmacy label on it.
Paracetamol / ibrofrofen and anti histamine if you have signed a consent form, if we feel it is necessary to enable your child to remain in school and no more than twice in a 2 week period for the same symptoms.
Trained staff will oversee the administration of the medication which has been supplied by the parent.
It is the parent's responsibility to supply the appropriate medication and ensure that it is in date. A medical form must be completed. Inhalers are self-administered.
Two inhalers and a spacer must be supplied, all of which must be named and kept in the medical room for use as required. A member of the first aid team will oversee the administration of inhalers. During off-site activities it is the parent's responsibility to supply their child with the relevant medication and hand to the First Aider.
If larger essential medical equipment is required for school trips such as portable nebulisers, then the parent must supply the equipment to the school in a bag that is named and the machine/unit is complete and ready for use. The parent/guardians should note that the school cannot be held responsible for loss, damage, maintenance of any piece of equipment.
It is imperative that all children are protected against the sun. In the summer months, children must be provided with a sunhat. Sun cream should be applied before school, you can buy sun cream that is designed to last the whole day. If your child is able to apply their own sun cream, they are able to bring it into school and top it up during the day.


text:
Memorable Manitobans: Richard Norton (1701-1741)
HBC governor, explorer.
He first came to the Bay in 1714. He was a member of the advance party sent to establish a post at Churchill River in 1717, experiencing much privation and danger during the winter of 1717-18. He probably got as far north as latitude 60°. He commanded Fort Prince of Wales in 1723 and was moved as second-in-command to York in 1726. He returned to the Bay in 1731 as chief factor and commander of Fort Prince of Wales, and he spent much of his effort constructing a stone building on the site. He was reprimanded for disregarding orders in 1739, and he died shortly after his return to England in 1741.
Richard Norton, Dictionary of Canadian Biography III, 489-90.
Dictionary of Manitoba Biography by J. M. Bumsted, Winnipeg: University of Manitoba Press, 1999.
Page revised: 12 April 2008


One of my BBBs AMC started a new linky party Why'd I Buy It and I think it will be very beneficial for teachers to find out about some great resources from reliable reviewers who use these items in our classrooms!
First up is the phone charger-I bought this when I went to Vegas since I knew I wouldn't be able to charge my phone during the day. I purchased it on Amazon and it received mostly good reviews, but I knew I needed something fast before I left, so I ordered it with my Prime membership hoping I'd be happy with this purchase. Well...I was very happy with it! It's a very small charger (lipstick-size) that fits in your purse, it's only $20, and it's pink! :) My phone drained so quickly when I was in Vegas, but I always was able to use my back up charger right in my purse! I definitely recommend this purchase!
Next up was just for fun...aren't these bright nail polishes so fun?
Guess what? They're even more fun because they're highlighters!!! I can't wait to bring one of these to a faculty meeting! Everyone will think I'm going to paint my nails-LOL!
Last is my favorite...if you follow my blog, you know I love black & white with bright colors. I love using pocket charts, but that blue just doesn't match my décor. A couple of years ago I tried to dye one of my blue pocket charts, that was an epic fail. Then last year, I decorated it with some black and white chevron ribbon to give it a little decorative touch. Now, finally, Scholastic got smart and read blogs and Pinterest posts everywhere of how teachers have tried to change the color of their pocket charts and they now sell BLACK POCKET CHARTS!!!
Can you hear me squealing in Florida?
Thanks Scholastic for hearing us!
I made some name tags for my classroom to match my theme. I had several inquiries about the pictures on my blog since you can see the name tags in the background, so I decided to list them in my TPT Store. I've offered several versions (editable, color, black & white). Click here if you're interested. I like how clean and crisp they look and my students have referred to them several times already during math! A win-win!
Hope you're having a super week! Two more days and then a long weekend!
That nail polish/highlighter is too cute!! I am so jealous of your black pocket chart - I saw them earlier this summer but they were not available in Canada (it said to pre-order for January!!!). I don't even want to use my stupid blue ones - I just want to wait!!! I considered dyeing them but have heard horror stories about that. Oh well, I will let me family know that they would make a great Christmas gift. Thanks for linking up!!
Those lipstick highlighters are hilarious!! I also love your "The Best Part of Me" board in the background. I have seen that on Pinterest and am hoping to do it myself this year. (It looks great in black and white.) Have a great day!!
I'm with you! Yeah for black pocket charts! I bought all three that Scholastic offers! I went into my local teacher store and they didn't even KNOW about them! Hello! Order those suckers STAT! I got mine right in time for the start of school.
Black pocket charts..............I AM SO EXCITED!!!!! I can hear you squealing and now I'm squealing too! Those highlighters look super fun too. I've missed you!!!!!!


When faced with the inevitable, a trusted advisor to guide you.
Nearly 1 million women are widowed annually in the United States. When faced with the loss of a spouse, you may need to make significant financial decisions and take action quickly, at a highly emotional time. Our advisors can help guide you through the complicated process of changing account names and/or titles, managing estate accounts, notifying life insurance companies and any other financial processes that need attention. It is important to have a trusted advisor to develop a plan going forward and guide you through to financial independence.


There's nothing quite like a walk-off touchdown.
The second touchdown of the night for Otis Harris was decisive, because it came in overtime and gave Spain Park a thrilling 19-13 victory over national power Prattville.
Harris led the Jaguars' offense with 110 yards on 28 carries, but it was his second touchdown that will go down in the annals of Spain Park history.
Prattville had taken the lead, 16 to 13, with a field goal in their overtime possession. The Harris touchdown ended the game and provided one of the great victories in Spain Park history.
Overtime was a fitting result for such an evenly played game. The teams were only 14 yards apart in total offense (299 to 285), and were only one first down apart (16 to 15).
Quarterback Mickey Forrest led the aerial attack with 175 yards passing, completing 15 of his 24 attempts. Dalton Brown had 75 yards receiving on only three catches, and Derek Williams added 48 yards on four catches.
The Jaguars' defense kept the game close, allowing only 13 points in four quarters of regulation play. Star running back and Auburn commitment Kamryn Pettway, rushed for 159 yards, but the Spain Park defenders held the rest of the team to only 140 yards.
Next week, Spain Park hosts the Chelsea Hornets (1-1), who suffered a 25-23 loss to Thompson.


text:
The UK press is already on XR's side
The 'billionaire-owned', 'right-wing' press is full to the brim with climate-change alarmism.
Ben Pile
Topics Free Speech Politics UK
Extinction Rebellion's decision to block the delivery of certain 'right-wing' newspapers across the UK on Saturday morning has been rightly condemned as a violation of press freedom by politicians and the print media alike. The Telegraph announced that it 'will not be silenced', prime minister Boris Johnson said XR's actions were 'completely unacceptable', while Labour leader Sir Keir Starmer declared that 'the free press is the cornerstone of democracy and we must do all we can to protect it'.
Yet while the press criticised XR's actions, they were also keen to display their own support for the environmentalist agenda. The Sun claimed that it had highlighted 'climate change for years', and pointed out that Saturday's blockaded edition even included a comment piece by broadcaster-cum-eco-alarmist David Attenborough. The Telegraph urged XR to 'welcome this government's drastic carbon-emission plans'. And The Times carried a piece by Robert Colvile, from the Centre For Policy Studies (CPS), who outlined his support for 'carbon taxes, emissions offshoring, the hydrogen revolution, clean-air zones, green tech', and stated that he was very concerned by 'humanity's alarming impact on the planet'.
And this is what is striking about Britain's free press. When it comes to climate change, our newspapers all toe the same environmentalist line, publishing countless pieces supporting the green agenda while repeatedly warning of 'humanity's alarming impact on the planet'. On this issue, there might as well not be a free press. Such is the green consensus, there might as well be just one political party, one newspaper and probably just one journalist.
Not that XR activists seem to have read many newspapers recently. They genuinely seem to think the 'billionaire-owned', 'right-wing' press is pumping the public full of so-called climate-change denial. But, as the media's response to XR makes plain, nothing could be further from the truth. Newspapers, from the Sun to the Telegraph, are thoroughly in favour of the green agenda.
Take CapX, an online magazine founded to make the case for capitalism. One might expect it to be at the forefront of so-called climate-change denial. And, yes, its editor John Ashmore has been critical of XR, saying that its apocalyptic framing of climate change is likely 'to make the public despair' rather than 'take meaningful action'. That the public should take meaningful action to combat climate change is not in question, however. In fact, Ashmore shares with XR an environmentalist worldview. He just disagrees with its tactics. Indeed, the pro-capitalist Ashmore even seems to share XR's view that a radical transformation of our economic system is needed, praising the government's law pledging to achieve a net-zero economy by 2050 – 'an extraordinarily radical change in the structure of the British economy'.
What is incredible is the government's commitment to cut greenhouse gas emissions in the UK to almost zero by 2050 – this 'extraordinary radical change in the structure of the British economy' – has effectively passed without comment, criticism, dissent or debate on the pages of the British 'free press'. The papers agree. The journalists agree. The think-tanks agree. The broadcasters agree.
Despite XR's claims, the British press propagates near enough the same message on climate change. As the papers present it, climate change really is the biggest problem facing mankind, and we must do everything we can to mitigate its worst effects, even if that entails economic immiseration. There is no dissent. And no diversity of opinion. And this is a massive problem. Editors', journalists' and think-tankers' decision not to contest the environmentalist basis on which deep changes to society are being made is depriving the public of a forum in which to question and debate climate change and green policymaking.
We should call out XR for its anti-democratic stunts. But until newspapers start living up to Starmer's claim that they are 'a cornerstone of democracy', they shouldn't be surprised when many of us stop buying them.
Ben Pile blogs at Climate Resistance.
Picture by: YouTube.
Tags Boris Johnson Climate change Conservative Party Environment Extinction Rebellion Keir Starmer Labour Party Media Press freedom


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Emergency Management and Safety Solutions
H1N1 (Swine Flu): Seriously Ill Patients May Have Unusual Damage in Lungs
Researchers have reported in the online version of American Journal of Roentgenology (AJR) that H1N1 may cause blood clots and other unusual damage in the lungs. Two studies show the need to check X-rays and CT scans for unusual features. The study also pointed out that H1N1 can be tricky to diagnose in some of the sickest patients. While H1N1 remains for the most part a mild illness, it is sickening many younger adults and older children who usually escape the worst effects of seasonal flu. These studies will be appear in print in the December 2009 issue of the AJR.
Unusual Lung Changes
"It is essential that clinicians be able to recognize possible cases of pandemic H1N1 influenza in high-risk groups so that they order the appropriate diagnostic tests, begin specific antiviral therapy, and prepare to provide intensive supportive measures as needed," noted Dr. Daniel Mollura of the National Institutes of Health Clinical Center in Maryland and colleagues.
An example of this was a middle-aged man who died was not diagnosed until after death, but unusual findings on his X-rays may be able to help doctors save other, similar patients.
Mollura's team found irregularities called ground-glass opacities in the patient's lungs using a CT scan. Although the patient was severely ill and had a fever, he tested negative for flu and doctors did not treat him for it. The man died five days after he went into the hospital and the autopsy confirmed he had swine flu. The lung lesions seen on his CT scan matched lung damage done by the virus, Mollura and colleagues said.
In another study in the same journal, CT scans of patients with severe cases of swine flu showed many had pulmonary emboli, which block the arteries in the lungs, a team at the University of Michigan found.
Anticoagulant drugs can break up these clots and save lives.
Dr. Prachi Agarwal and colleagues examined 66 patients diagnosed with H1N1, 14 of them who were in the intensive care unit. All 66 got standard X-rays, which can show if a patient has pneumonia. They performed enhanced X-rays known as computed tomography or CT scans on 15 of the patients, 10 of them who were in the ICU on ventilators to help them breathe. Five of the ICU patients had the blood clots in the lungs, Agarwal reported. "Our study suggests that patients who are severely ill with H1N1 are also at risk for developing pulmonary emboli, which should be carefully sought for on contrast-enhanced CT scans," Agarwal said in a statement.
An example of a pulmonary emboli. "The majority of patients undergoing chest X-rays with H1N1 have normal radiographs (X-rays)," she added. Pulmonary emboli are also not normally seen in flu, she said. "CT scans proved valuable in identifying those patients at risk of developing more serious complications as a possible result of the H1N1 virus, and for identifying a greater extent of disease than is appreciated on chest radiographs."
http://www.nlm.nih.gov/medlineplus/news/fullstory_90673.html
http://www.ajronline.org/aheadofprint/12_09_3599.dtl
previous post: H1N1(Swine Flu): Pandemic Flu Myths- Man-Made, Planted Weapon and More! And No Joke, Ferret Gets Flu From Owner!
next post: H1N1(Swine Flu): Clinical picture of H1N1 severe cases; Pneumonia Vaccine; US Pigs Catch the Flu
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Q: OCaml return values In the book 'Developing Applications with OCaml', there is the following explanation regarding return values:

As the value preceding a semicolon is discarded, Objective CAML gives a warning when it is not of type unit.
# print_int 1; 2 ; 3 ;;
Characters 14-15:
Warning: this expression should have type unit.
1- : int = 3

To avoid this message, you can use the
function ignore:

# print_int 1; ignore 2; 3 ;;
1- : int = 3`

I don't understand why it would be a problem that 2 has a return value diferent than unit, because my intention is not to return 2, but to return 3. The way I understand it, any instruction preceding my very last instruction is not the return value of the function, so why the warning?
I've been having this warning all over my code and it is becoming clear to me that I don't really understand how return values really work in OCaml.
Thanks for your help.

A: Consider expression e1 ; e2. By definition - evaluating this whole expression results in evaluation of e1 and then e2 and the resulting value of the whole expression is the value of e2. Value result of e1 is discarded. This is not the problem if the type of e1 is unit cause it has the only single inhabitant value (). For all the other types discarding the result of e1 means loosing information which is probably not what the programmer intended, hence the warning. The programmer has to explicitely ignore the result value, either with ignore or with
let (_:type) = e1 in
e2

Type annotation can be omitted but it may be useful to be sure that e1 is fully evaluated to the expected type (not a partial application).

A: Well, the warning is there because the fact that you produce a value but then don't use it may be (and very often is) an indication that you are doing something wrong. If you don't agree with this policy you can turn off that warning. But as usual it's a good practice not to do that, in which case, if you really don't need a value of an expression you can indeed use ignore or bind it to _, as in let _ = f() in ....

redpajama_set_name: RedPajamaStackExchange


text:
Thought you might appreciate this item(s) I saw at Pharmacogenetics and Genomics.
SHORT COMMUNICATIONS
Polygenic heritability estimates in pharmacogenetics: focus on asthma and related phenotypes
McGeachie, Michael J.a,b,e; Stahl, Eli A.f; Himes, Blanca E.a,b,e; Pendergrass, Sarah A.g; Lima, John J.h; Irvin, Charles G.i; Peters, Stephen P.j; Ritchie, Marylyn D.g; Plenge, Robert M.e,c; Tantisira, Kelan G.b,d,e
aPartners Healthcare Center for Personalized Genetic Medicine
bDepartment of Medicine, Channing Division of Network Medicine
cDepartment of Medicine, Division of Rheumatology, Immunology and Allergy
dDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital
eHarvard Medical School, Boston, Massachusetts
fMt Sinai School of Medicine, Division of Psychiatric Genomics, New York, New York
gDepartment of Biochemistry and Molecular Biology, Center for Systems Genomics, Pennsylvania State University, University Park, Pennsylvania
hCenters for Clinical Pediatric Pharmacology and Pharmacogenetics, Nemours Children's Clinic, Jacksonville, Florida
iDepartment of Medicine and Physiology, Vermont Lung Center, University of Vermont, Burlington, Vermont
jCenter for Genomics and Personalized Medicine Research, Wake Forest University, Winston-Salem, North Carolina, USA
Correspondence to Michael J. McGeachie, PhD, Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Ave, Boston, MA 02115, USA Tel: +617 525 2270; fax: +617 525 0958; e-mail: mmcgeach@csail.mit.edu
Received October 9, 2012
Accepted February 11, 2013
Pharmacogenetics and Genomics: June 2013 - Volume 23 - Issue 6 - p 324-328
doi: 10.1097/FPC.0b013e3283607acf
Although accurate measures of heritability are required to understand the pharmacogenetic basis of drug treatment response, these are generally not available, as it is unfeasible to give medications to individuals for which treatment is not indicated. Using a polygenic linear mixed modeling approach, we estimated lower bounds on the heritability of asthma and the heritability of two related drug–response phenotypes, bronchodilator response and airway hyperreactivity, using genome-wide single nucleotide polymorphism (SNP) data from existing asthma cohorts. Our estimate of the heritability for bronchodilator response is 28.5% (SE 16%, P=0.043) and airway hyperresponsiveness is 51.1% (SE 34%, P=0.064), whereas we estimate asthma genetic liability at 61.5% (SE 16%, P<0.001). Our results agree with the previously published estimates of the heritability of these traits, suggesting that the linear mixed modeling method is useful for computing the heritability of other pharmacogenetic traits. Furthermore, our results indicate that multiple SNP main effects, including SNPs as yet unidentified by genome-wide association study methods, together explain a sizable portion of the heritability of these traits.
© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Pharmacogenetics and Genomics23(6):324-328, June 2013.
airway hyperresponsiveness, asthma, bronchodilator response, heritability, pharmacogenetics
Articles in PubMed by Michael J. McGeachie
Articles in Google Scholar by Michael J. McGeachie
Other articles in this journal by Michael J. McGeachie


Whoever acknowledges me before men, I will also acknowledge him before my Father in heaven.
With these words Jesus indicates that he wants Christians to confess publicly what they believe in their hearts.
This We Believe is one way the members of the Wisconsin Evangelical Lutheran Synod have chosen to confess their faith in Christ. This document publicly summarizes the main teachings of our church body.
This We Believe was first published in 1967. A minor revision was undertaken in 1980. In consultation with the Conference of Presidents, the Commission on Inter-Church Relations completed the present revision in 1999. This second revision seeks to simplify the language and to add some important points of doctrine not addressed in the first two editions. The current revision was not undertaken because of doctrinal disagreement with the previous editions.
The current document (see links below) does not claim to be a full treatment of all the Bible's teachings. For a fuller exposition of the doctrines of Scripture, the reader is referred to other sources, including the pamphlet Doctrinal Statements of the WELS (Northwestern Publishing House, 1997).
It should also be noted that This We Believe was not specifically designed to serve as an outreach tool for unchurched people, but as a basis for doctrinal discussions with other church bodies and informed individuals.
It is our conviction that over the years This We Believe has been a great blessing to the church. This revised edition is presented with the fervent prayer that it may continue to serve Christ's church, to the glory of his name and for the extension of his kingdom.


I understand that the price may not seem reasonable; however, this is intended to be a great conversation piece with great TY collectability. If you have a question for me, please reach out to me. However, should you want to ad this Diana baby to your collection send me a reasonable offer.
I have the PVC first edition no stamp and no space in my store and the one in this listing with a space. Feel free to check out my other beanie babies: I will be uploading more TY's within the next few weeks at reasonable prices..
I've had reporters reach out to me over this listing and many people asking for help with their personal collection. In a nut shell the listing is doing its purpose. I have been able to speak to people I would have never been able to speak to and have had opportunities to explain the price on this listing in personal conversations. He had 2 lovely children my daughters age and an infant. I wanted to do what I could to try to assist.
I serve a mighty God and even though I had to be patient; it ultimately got corrected. I can handle any bad feelings you have about this listing and any ridiculous offers as I understand the price is truly high.
Any advertising is good advertising.. I hope this clears up some of the controversy: thank you to my new friends and to all of the followers. My hope and prayer for each of you is uncompromised success in your Journey. Please do not take offense if it takes me a while to respond. Thank you for trusting KooymansFinds for your everyday wants and needs. Our goal is uncompromised integrity and unmatched customer service. We stated while I was undergoing Chemo and Radiation and was unable to work. I was able to reach my goals of paying my premiums and became a survivor in 2011 for the second time.. After all that my daughter witnessed at a young age we decided to use our store to show her that hard work, with something enjoyable can yield otherwise, open the door to hat may seem as an unobtainable dream. Every aspect of the business. I enjoy that as well; however, what if we could build a real relationship with one another? This would take -Commerce to another level.
I've always prided myself in in-matched customer service as I understand that without my customers/clients then I would have never made it this far. Next year she reaches the age that we set our goal to take her to Disney World. This trip will not undo what she went through; however, it will promote forward thinking and hope.


450k annual cases of CDAD reported in hospitals. Estimate that there are an additional 250k afflicted, some estmates as high as 3m per year.
OPTR does not believe it makes sense to do trial comparing to flagyl. metronidazole is not an approved drug for this indication and has serious deficiencies in cure rate. >20% fail and an additional 27-30% fail in recurrence. This product is consistently losing sales to vancomycin.
Discrepancy between the two phase 3 trials? one trial noninferior. one trial clearly superiority to vanc. in subpopulation with BI strain. OPTR don't have explanation except that trial not powered to detect differences in any such sub-populations.
It is not feasible to screen Cdif strain before tx. Strains also change over time. It is not clear when or if there will ever be clinical practice based on the given strain a pt has.
I have been promising some follow-up notes on the following passage in the 2010 AIS 10k annual report: "We are aware of two related U.S. patents issued to Watson Pharmaceuticals relating to a gel formulation of oxybutynin (Gelnique®). We believe that we do not infringe these patents and that they should not have been granted. We may seek to invalidate these patents but there can be no assurance that we will prevail. If the patents are determined to be valid and if Anturol® is approved, we may be delayed in our marketing of Anturol® or incur significant expenses defending our patent position which may adversely affect the potential market value of Anturol®"
Obviously, this issue has serious implications for 1) AIS's ability to partner Anturol in the coming months and 2) the ability to launch and sell Anturol in the market.
I am by no means a patent expert, so hopefully someone else out there can chime in regarding the relative strength and validity of these Watson Pharma $WPI patents!
Using the searchable USPTO database, I located 7 patents issued to WPI related to oxybutynin, and will briefly post pertinent info for each of these.
US patent #6,743,441: "The present invention provides compositions and methods for administering oxybutynin while minimizing the incidence and or severity of adverse drug experiences associated with oxybutynin therapy. In one aspect, these compositions and methods provide a lower plasma concentration of oxybutynin metabolites, such as N-desethyloxybutynin, which is presumed to be contributing at least in part to some of the adverse drug experiences, while maintaining sufficient oxybutynin plasma concentration to benefit a subject with oxybutynin therapy. The invention also provides isomers of oxybutynin and its metabolites that meet these characteristics of minimized incidence and/or severity of adverse drug experiences, and maintenance of beneficial and effective therapy for overactive bladder."...This patent only references transdermal patch, but not gel product. No issue for AIS.
US patent #7,029,694: "The present invention provides compositions and methods for administering oxybutynin while minimizing the incidence and or severity of adverse drug experiences associated with oxybutynin therapy. In one aspect, these compositions and methods provide a lower plasma concentration of oxybutynin metabolites, such as N-desethyloxybutynin, which is presumed to be contributing at least in part to some of the adverse drug experiences, while maintaining sufficient oxybutynin plasma concentration to benefit a subject with oxybutynin therapy. The invention also provides isomers of oxybutynin and its metabolites that meet these characteristics of minimized incidence and/or severity of adverse drug experiences, and maintenance of beneficial and effective therapy for overactive bladder. In some aspects, the composition may be presented in the form of an unoccluded or free form topically administered gel....What is claimed is: 1. A method of treating with oxybutynin a subject having overactive bladder, while minimizing an anticholinergic or antimuscarinic adverse drug experience associated with said oxybutynin treatment therapy comprising the step of: administering as a topical gel, a composition comprising oxybutynin to a subject to provide a plasma area under the curve (AUC) ratio of oxybutynin to an oxybutynin metabolite of from about 0.5:1 to about 5:1, wherein the topical gel optionally includes a permeation enhancer...."...This is continuation-in-part of the above patent. Filed 11/1/2002, issued 4/18/2006. This is clearly one of the two patents referenced by AIS as a potential impediment to launch of Anturol.
US patent # 7,081,249: "The present invention provides compositions and methods for administering oxybutynin while minimizing the incidence and or severity of adverse drug experiences associated with oxybutynin therapy. In one aspect, these compositions and methods provide a lower plasma concentration of oxybutynin metabolites, such as N-desethyloxybutynin, which is presumed to be contributing at least in part to some of the adverse drug experiences, while maintaining sufficient oxybutynin plasma concentration to benefit a subject with oxybutynin therapy. The invention also provides isomers of oxybutynin and its metabolites that meet these characteristics of minimized incidence and/or severity of adverse drug experiences, and maintenance of beneficial and effective therapy for overactive bladder."...This patent references only the patch- no issue for AIS.
US patent #7,081,250: "The present invention provides compositions and methods for administering oxybutynin while minimizing the incidence and or severity of adverse drug experiences associated with oxybutynin therapy. In one aspect, these compositions and methods provide a lower plasma concentration of oxybutynin metabolites, such as N-desethyloxybutynin, which is presumed to be contributing at least in part to some of the adverse drug experiences, while maintaining sufficient oxybutynin plasma concentration to benefit a subject with oxybutynin therapy. The invention also provides isomers of oxybutynin and its metabolites that meet these characteristics of minimized incidence and/or severity of adverse drug experiences, and maintenance of beneficial and effective therapy for overactive bladder."...This patent references only the patch- no issue for AIS.
US patent #7,081,251: "The present invention provides compositions and methods for administering oxybutynin while minimizing the incidence and or severity of adverse drug experiences associated with oxybutynin therapy. In one aspect, these compositions and methods provide a lower plasma concentration of oxybutynin metabolites, such as N-desethyloxybutynin, which is presumed to be contributing at least in part to some of the adverse drug experiences, while maintaining sufficient oxybutynin plasma concentration to benefit a subject with oxybutynin therapy. The invention also provides isomers of oxybutynin and its metabolites that meet these characteristics of minimized incidence and/or severity of adverse drug experiences, and maintenance of beneficial and effective therapy for overactive bladder"...This patent references only the patch- no issue for AIS.
US patent #7,081,252: "The present invention provides compositions and methods for administering oxybutynin while minimizing the incidence and or severity of adverse drug experiences associated with oxybutynin therapy. In one aspect, these compositions and methods provide a lower plasma concentration of oxybutynin metabolites, such as N-desethyloxybutynin, which is presumed to be contributing at least in part to some of the adverse drug experiences, while maintaining sufficient oxybutynin plasma concentration to benefit a subject with oxybutynin therapy. The invention also provides isomers of oxybutynin and its metabolites that meet these characteristics of minimized incidence and/or severity of adverse drug experiences, and maintenance of beneficial and effective therapy for overactive bladder."...This patent references only the patch- no issue for AIS.
US patent #7,087,241: "The present invention provides compositions and methods for administering oxybutynin while minimizing the incidence and or severity of adverse drug experiences associated with oxybutynin therapy. In one aspect, these compositions and methods provide a lower plasma concentration of oxybutynin metabolites, such as N-desethyloxybutynin, which is presumed to be contributing at least in part to some of the adverse drug experiences, while maintaining sufficient oxybutynin plasma concentration to benefit a subject with oxybutynin therapy. The invention also provides isomers of oxybutynin and its metabolites that meet these characteristics of minimized incidence and/or severity of adverse drug experiences, and maintenance of beneficial and effective therapy for overactive bladder."...This patent related to "transmucosal formulation…selected from the group consisting of a buccal tablet, a sublingual tablet, or an adhesive film."-no issue for AIS.
US patent #7,179,483: "The present invention provides compositions and methods for administering oxybutynin while minimizing the incidence and or severity of adverse drug experiences associated with oxybutynin therapy. In one aspect, these compositions and methods provide a lower plasma concentration of oxybutynin metabolites, such as N-desethyloxybutynin, which is presumed to be contributing at least in part to some of the adverse drug experiences, while maintaining sufficient oxybutynin plasma concentration to benefit a subject with oxybutynin therapy. The invention also provides isomers of oxybutynin and its metabolites that meet these characteristics of minimized incidence and/or severity of adverse drug experiences, and maintenance of beneficial and effective therapy for overactive bladder. In some aspects, the composition may be presented in the form of an unoccluded or free form topically administered gel...What is claimed is: 1. A method of treating with oxybutynin a subject having overactive bladder, while minimizing an anticholinergic or antimuscarinic adverse drug experience associated with said oxybutynin treatment therapy comprising the step of: administering a transdermal formulation comprising oxybutynin to a subject to provide a plasma area under the curve (AUC) ratio of oxybutynin to an oxybutynin metabolite of from about 0.5:1 to about 5:1, wherein the transdermal formulation optionally includes a permeation enhancer, and wherein the transdermal formulation is in the form of: (a) topical formulation selected from the group consisting of ointments, lotions, gels, pastes, mousses, aerosols and skin creams, or (b) transdermal patches selected from the group consisting of adhesive matrix patches and liquid reservoir systems"...This would appear to be the second of the two patents referenced by AIS as a potential impediment to launch of Anturol.
US patent #7,921,999: "A peelable pouch comprises a substantially flat enclosure formed by first and second opposing flexible plies. A seal extends along at least a portion of a perimeter of the opposing plies. A flat, flexible transdermal patch is disposed in the enclosure and includes a bioactive agent dissolved in a layer of adhesive. A release liner is removably attached over the layer of adhesive, with the patch and the release liner together being sufficiently resilient so as to generate a spring force when displaced out of the flat configuration. The first and the second plies each being separable along the seal and displaceable out of the flat configuration. The spring force generated by the patch and the release liner being sufficient to overcome an adhesive force created by the adhesive between the patch and one of the plies."...This patent references only the patch- no issue for AIS.
Thanks to Bill, who posted a very thoughtful comment on the blog recently- I've decided to reply at some length here as it raises a number of important points. Quoted passages in gray are from the original comment and my responses are in blue below.
"I was reading through some abstracts presented at a recent meeting at the American Urologic Association in Washington DC from this week. I'm not sure if you can get access to it. There was one interesting presentation on HSDD in women presenting at urologist office. The abstract basically found that a high number of women on the whole have hypoactive sexual disorder and especially women in their 40's and 50's."
"This study had no financial disclosures (so it was done independently and should be unbiased); I think it will be hard for the FDA to claim this isn't a disorder."
INTRODUCTION AND OBJECTIVES: HSDD is the most common sexual desire disorder found in women. Multiple comorbidities may contribute to low sexual desire, specifically those found in women seeking care from a urologist. Our objective was to determine the prevalence of low sexual desire in women presenting to the urology office for a variety of reasons. A secondary objective was to determine factors that may contribute to having low desire. METHODS: This was a prospective study of female patients presenting to the urology office for any reason (stones, hematuria, prolapse, incontinence, etc.). Female subjects over the age of 18 were offered the Decreased Sexual Desire Screener (DSDS). Patients answering "yes" to the first 4 questions on the DSDS represented the cohort qualifying for a diagnosis of HSDD, pending physician evaluation to see if any other factors (listed in item 5 on the DSDS) can impact low desire. Demographic factors as well as diagnosis codes were recorded and analyzed. Descriptive statistics, univariate and multivariate logistic regression were used in order to determine any predictors of low desire.
RESULTS:Overall 339 women completed the DSDS. 273 (81%) had a decrease in sexual desire, with 95 (28%) qualifying for a possible diagnosis of HSDD by answering "yes" to items 1 through 4 on the DSDS. Women between the age of 41 and 52 were most likely to qualify for a diagnosis of HSDD with 37% of this age group qualifying. Factors such as marital status, employment status, race and BMI did not contribute to low desire, nor did diagnosis code. The presence of low sexual desire was common among women presenting with stones, incontinence, prolapse, infection, retention, pain, voiding dysfunction and malignancy. No one diagnosis code was predictive of women having low sexual desire or HSDD.
CONCLUSIONS:The presence of low sexual desire is common in all women presenting to the urology office. Specifically, women between the ages of 41 and 52 are at an increased likelihood of having a diagnosis of HSDD. Because many women are hesitant to bring up these complaints, urologists should be aware of sexual desire issues and question their patients on sexual function.
This presentation underscores that HSDD is a common phenomenon in the female population, as both BPAX's research, other journal articles, and an FDA advisory panel have stated.
"I realize BPAX is going after post-menopausal patients in their study, but this was still very high number."
You are correct that BPAX is going after the menopausal population. While the safety study is being completed in older (>50 yrs) women, the two phase 3 efficacy trials are in surgically menopausal women as young as 35 yrs old, so the age range highlighted in the abstract has a great deal of overlap with a potential Libigel label.
"As a physician, i don't think a small amount of testosterone is going to have significant side effects and especially in any type of study looking at 5 yr outcomes. The FDA are always unpredictable, so no one know for sure, but i think this has a great shot. The FDA will be pressure to approve a "female viagra", even though testosterone works much different that viagra. Men use testosterone all the time and this is a growing market; men probably have a lot higher risk of prostrate cancer than women have of developing any cancers (and it may actually lower their risk of cancer (but probably slightly increase risk of heart problems over the long term); looks like bpax is being smart and really getting all the studies that the fda may want ; they should be nearing full enrollment."
I agree with your conclusions- I feel that the clinical risk for both the safety and efficacy trials is quite low for Libigel compared to the average phase 3 program. They have over a thousand women who have been taking the gel for over a year, so I would be shocked to see a harmful effect appear at this point since the data safety monitoring board has been meeting so frequently. The point that male ED patients have had treatments available for years is frequently brought up by BPAX and is valid, so long as BPAX successfully jumps thru the hoops that the FDA has laid out. The safety study will be completely enrolled no later than August 2011. It is important to remember that the dose of testosterone in Libigel is orders of magnitude lower than the doses in male testosterone products- which is why they are difficult to use off-label for women and another reason why serious safety concerns in the Libigel pt population is unlikely.
"Not sure when bpax bumps, but probably not significantly until after fda approval. Their move to get fda approval for their men's gel is probably to see what problems the fda may raise with their delivery system prior to submitting for the women. Looks like a smart move!"
Clearly BPAX has had a significant bump in share price from <$2 to near $3 recently. I think the completion of enrollment in safety trial and data from efficacy trials have the potential to be additional catalysts, but I am not sure by how much it could appreciate before approval or partnering. It is important to note that the male Bio-T-Gel product developed by Teva and BPAX is not based on the same technology as Libigel, so this product has little bearing on the FDA review of Libigel. However, BPAX did get an estrogen gel product approved by the FDA that is based on the same Antares Pharma gel technology as Libigel.
"I am convinced this is the next provenge, the only difference is that testosterone in women actually works; provenge really doesn't work that well and i couldn't believe they got approved! I've never written before, so i guess i'm supposed to state my disclosure; i am "long" on bpax"
I'm not sure Provenge is the comparison I would make, but I can see it in that if Libigel is approved and becomes a success, it will have navigated a long and difficult road against tall odds and with many doubters. Note of course that more hurdles remain for Libigel (the least of which are the clinical trial data), as they do for Provenge before $DNDN will have grown into its current market valuation.
Sorry that my twitter feed has been missing most of the day, I'm sure I missed some great stuff and hope they resolve this soon.
Goal: identify and neutralize mechanisms of treatment resistance in order to get better patient outcomes.
Early stage: not much change.
symptomatic setting:- chemotherapy. haven't seen success (avastin and AZN failed combos w/ docetaxel). This is the population for Synergy trial.
OS results are associated w/ decrease in clusterin levels.


Radon is a naturally occurring, radioactive noble gas, which can seep into buildings through the ground. Switzerland is particularly affected by this problem due to its geology. The current radon protection strategy is set out in the 2012-2020 action plan.
Radon is a naturally occurring, radioactive noble gas, which forms in the soil.
Radon infiltrates houses from the soil, which can lead to a pollution of the indoor air.
Radon is the primary cause for lung cancer after smoking.
Legal values have been defined for the radon concentration indoors.
It is easy and cheap to measure the radon level in a building.
Radon consultants with an education approved by the FOPH provide advice regarding appropriate protection measures against radon.
It is possible to protect a building from high radon levels by adopting simple measures.
Based on the performed measurements all communities in Switzerland have been classified according to their radon risk.
In the year 2011 the Swiss federal council has passed the national action plan regarding the protection against radon in residential and common rooms.


Craig Thompson is a cartoonist and the author of the award-winning books Blankets; Good-bye, Chunky Rice; Habibi; Space Dumplins. He was born in Michigan in 1975, and grew up in a rural farming community in central Wisconsin. His graphic novel Blankets won numerous industry awards and has been published in nearly twenty languages. Thompson lives in Portland, Oregon.
Craig Thompson attends TCAF in support of his new ongoing comic series Ginseng Roots, which debuts at TCAF as part of the 10th Anniversary Celebration of Uncivilized Books!


Russian Army White Fake Fur Ushanka Hat with Soviet Army Soldier Badge - Kids, children size. Boys or Girls. With metal badge.
There is no one in the world who has never heard about Russian ushanka hats. These hats are really known all over the world for their design and comfort. Initially designed for Russian soldiers, today they gain more and more popularity among both young and elder people. But why?
No doubt, it is due to their unique construction. Generally, the word «ushanka» can be translated from Russian as «the one with ears». That means that this unusual head-dress has special ear-flaps, which are initially tied at the top of the hat. When it is cold or windy, you can untie them and lay down, or tie under the chin or at the back of the head. This helps to protect your face, chicks and ears from cold weather and make you feel warm and cosy. It is really a very practical and comfortable accessory which has no analogues. And it is indeed simple but genius invention. That is why it is not surprising that ushanka hats are popular for about hundred years.
Though, the hats similar to ushanka were found even earlier in China and Korea, but real recognition they gained in Russian army, as because of severe weather conditions soldiers needed to stay warm and protected from cold wind in any case. In the US ushankas received their fame after the fall of Soviet Union and «Iron Curtain» which prevented exchange of experience between our countries.
Now there are plenty of forms of ushanka-like hats, but still the classical design of the SU Army officer ushanka remains the most comfortable and stylish accessory for anyone. Made of high quality fur and decorated with a military badge, it will be a great addition to your image or an unusual gift for your friend or colleague!


In late 1951, Eilis Lacey (Saoirse Ronan), a young Irish girl, emigrates to Brooklyn. Sponsored by Father Flood, a priest from her native town Enniscorthy, she is assured to find a full-time job there. But the early days are tough, seasickness being soon replaced by loneliness and homesickness, two feelings all the more acutely felt by Eilis for having had to leave behind her widowed mother and her dear sister Rose. She nevertheless little by little manages to find her footing by adapting to her job as a salesgirl, by studying bookkeeping at Brooklyn College as well as with a little help from both Father Flood and Mrs. Kehoe, the owner of the boarding school she now lives in. And not only does graduation follow but love shows its face in Tony, an Italian-American plumber, full of adoration and respect for her. They end up marrying, although keeping the thing secret. It is at that point that tragedy strikes: Rose suddenly dies. Which incites Eilis to return to Enniscorthy, in order to share her sorrow to support her mother morally. And there a strange thing happens : she gradually gets lured by the charms of her native place, going as as to let herself be wooed by Jim Farrell, a young local.
otsoNY Comments: Though this film was called Brooklyn, and part of the storyline was set in Brooklyn, it was in fact Montréal in Canada that doubled for Brooklyn.


The Parlour, the stylish restaurant at the Roger New York hotel overlooks the intimate lobby and features marble-topped round tables flanked by blue leather chairs, navy and cream striped banquettes and window seats, and a wide wood plank floor. Votive candles on the tables, soft lighting, low music, an interesting menu by Chef de Cuisine Peter Goldklang, and attentive service create an inviting and relaxing ambience.
Edward and I stayed at the hotel Roger New York in August 2012, and had an enjoyable and relaxing dinner at The Parlour, located on the third floor of the hotel. After spending the day exploring the city and seeing a few of the City's famous sights, it was wonderful to be able to dine-in and travel no further than a few floors by elevator to have dinner.
The restaurant has an appealing specialty cocktail menu and we began our evening with pre-dinner cocktails, The Roger made with strawberry puree, Fee Brothers Aztec Chocolate Bitters, and Prosecco, and the Rye Manhattan made with Bulleit Rye, sweet vermouth, and Peychaud's Bitters.
Chef de Cuisine Peter Goldklang is the talent in the kitchen and he surprised us with a delicious amuse bouché of a smoked salmon rosette on a round potato cake garnished with a caper as an introduction to stimulate our palates and serve as a taste of his culinary vision for the restaurant.
The menu has a distinct bistro feel with a selection of small plates, cheese specialties from the renowned Murray's in New York City, salads, sandwiches, large plates, and desserts. For his first course, Edward selected the Soda Dipped Fried Chicken from the small plates section of the menu served with a bowl of sriracha honey and sumac yogurt dipping sauce that provided an interesting balance of sweet hot and savory cool experiences.
I had the Oyster Po Boy, another small plate, consisting of delectable battered Chesapeake oysters and crunchy fennel slaw served on three miniature grilled brioches and accompanied by shaved fennel slaw.
Edward continued with the Chicken Paillard, a large plate selection, accompanied by fresh herbs, arugula, heirloom tomatoes, and garnished with a lemon wedge. The restaurant has a nice selection of wines by the glass as well as by the bottle. Edward paired his chicken course with an Erath Pinot Noir from Oregon.
I had the buttery and delectable Wild King Salmon glazed with mustard herb butter for my second course, another one of the large plates, served on a bed of pencil-thin and tender asparagus, and accompanied by a selection of multi-colored fingerling potatoes, which I complemented with a glass of Michel Redde Sancerre from the Loire Valley of France.
For dessert, Edward and I sampled the Ice Cream Sandwich, which was pistachio ice cream sandwiched between two chocolate cookies, and the Strawberry Rhubarb tart accompanied by vanilla ice cream enhanced with a swirl of dark chocolate on the plate.
At the end of a lovely dinner, we rode the elevator and were thrilled that we were "home" for the evening.
The Parlour serves breakfast from 6:00 am until 10:00 am, and lunch/dinner from 1:00 pm until midnight.
Read other materials on the Roger New York in the Hotels and Resorts section and in the Chefs' Recipes section where Chef de Cuisine Peter Goldklang graciously shares a taste of The Parlour.
Follow The Roger New York on Facebook at www.Facebook.com/TheRogerNewYork and Luxury Experience on Facebook at www.Facebook.com/LuxuryExperience.
Read other materials on New York in the Destination, Hotels and Resorts, Restaurant, and Chefs Recipes sections.
© September 2012. Luxury Experience. www.LuxuryExperience.com. All rights reserved.


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Henry Scrimgeour ou Scrymgeour, né à Dundee en 1505 et mort à Genève le , est un diplomate écossais et un bibliophile, qui a suivi les cours de l'ancienne université de Bourges au .

Biographie

Il est né à  Dundee en Écosse, très probablement en 1505, mais il est possible qu'il soit né en 1508 ou 1509, puisque Andrew Melville indique que Scrimgeour est décédé à soixante trois ans. Il a d'abord suivi les cours de l'école primaire de Dundee, pour ensuite se rendre à St Salvator's College, St Andrews en 1532. Il est fait bachelier en 1533 et gagne la première place à l'examen de licence l'année suivante. Quelque temps plus tard, il se rend à Paris où il étudie sous la férule de Guillaume Budé et de Pierre Ramus. Peu après, il va étudier le droit civil à Bourges pendant quatre ans avec Éguinaire Baron et François Douaren. Pendant son séjour à Bourges, il se lie avec Jacques Amyot, professeur de grec ancien et lui succède comme précepteur des fils de Guillaume Bochetel, le  secrétaire d'État de François  probablement pendant 3 ou 4 ans. En  il retourne en Écosse pour un court séjour. Bochetel lui donne une lettre de recommandation pour Marie de Guise, régente d'Écosse depuis 1542.

Le , avec la bénédiction de Calvin, Scrimgeour épouse Françoise de Saussure. En 1563 les pasteurs de Genève nomment Scrimgeour lecteur de  philosophie et la même année il est admis au Conseil des deux-cents. Plus tard, on le voit commencer à donner des leçons de droit civil. Lorsque Calvin meurt au printemps de 1564, Scrimgeour est témoin de son testament. Françoise de Saussure meurt le , âgée de vingt-cinq ans, laissant une enfant de trois ans derrière elle, Marie. Le  Scrimgeour est admis au Conseil des soixante, et le  il épouse Catherine de Veillet. Cette année, deux régents — les earls de Moray et de Mar — ainsi que George Buchanan cherchent à faire revenir en vain Scrimgeour en Écosse, pour les assister dans l'éducation du jeune Jacques VI ; mais Scrimgeour décline cette invitation, argumentant de son âge et de l'instabilité de l'Écosse. Henry Scrimgeour meurt à Genève le .

Précepteur, juriste et diplomate
De retour en France en 1548, Scrimgeour alors accompagné de son élève Bernardin Bochetel voyage en Italie et se rend à Padoue. Bien que de confession catholique, il est plongé dans les controverses de la Réforme protestante en Italie lors d'une visite à un jeune juriste, Francesco Spiera de Cittadella, qui était rongé par le désespoir après avoir adopté les opinions nouvelles et ensuite été conduit à les abjurer. Scrimgeour écrit un essai sur la piété, publié à Genève (sous le nom de Henricus Scotus) par l'imprimeur Jean Gérard avec une préface de Jean Calvin et daté de , intitulé  Exemplum memorabile desperationis in Francisco Spera, propter abiuratam fidei confessionem. Ce traité sera publié la même année à Bâle. Néanmoins, cette publication prend place quelques années avant que Scrimgeour declare publiquement son adhésion au protestantisme. Sa publication suivante sera un ouvrage de droit, une édition des Novelles, imprimée par Estienne à Genève en  et subventionnée par Ulrich Fugger. Le titre est : Impp. Justiniani, Justini, Leonis novellae constitutiones. Les Novellae étaient fondamentales pour enseigner le droit à cette époque et le besoin d'une nouvelle édition se faisait cruellement sentir. Scrimgeour a usé de ses contacts avec l'Ambassadeur de France à Venise pour avoir accès à un codex important appartenant au fond de la bibliothèque de Bessarion : son édition a reçu un accueil favorable de la part des juristes contemporains. La période entre 1558  et son dernier voyage en Italie en 1564 représente la partie la plus énergique d'une autre activité de Scrimgeour, celle de bibliophile; il est de nos jours acquis que la plus grande partie des manuscrits grecs, latins et hébreux de la collection Fugger ont été collectionnés par Scrimgeour, qui avait fréquemment voyagé entre Augsbourg et l'Italie. Cette collection Fugger fait aujourd'hui partie du cœur de la collection Palatine de la bibliothèque du Vatican à Rome. Scrimgeour fut aussi un agent dans l'achat de livres pour le compte de Otto-Heinrich, l'électeur palatin.

Scrimgeour conserva toute sa vie ses bénéfices en Écosse, mais il jouit aussi de revenus en France — il existe une autorisation qui lui a été accordée en 1556 par le roi Henri II de conserver et de recevoir des bénéfices dans sa patrie d'adoption.

Il s'était aussi engagé dans une carrière de diplomate, voyageant à Padoue, Venise, Florence, Rome, Milan, Mantoue et Bologne. Il chercha aussi sans succès à installer une imprimerie à Bourges. Bernardin Bochetel, devenu abbé de Saint-Laurent-des-Aubats, l'invitera plusieurs fois à Vienne, où il se rendra finalement en . Bochetel pourrait avoir eu besoin de ses services diplomatiques en vue de l'aider dans les difficiles négociations avec les princes luthériens, ou bien Durant le colloque de Poissy de 1561 entre les réformés et les catholiques, ou encore lors du concile de Trente, qui avait repris ses travaux en 1562 après une interruption de dix ans. Le séjour de Scrimgeour à Vienne fut bref, car il se trouvait à Genève à la fin de 1561.

Ulrich Fugger, devenu luthérien, avait conçu un plan pour une bibliothèque publique à Genève, en vue de mettre en sûreté son importante collection de livres rares, et Scrimgeour était associé à ce projet. Au même moment, le , il fut reçu par les magistrats de Genève au titre de bourgeois, trois ans après John Knox, et grâce à Calvin il s'impliqua rapidement dans la vie publique de la ville.

Sources
 Marie-Claude Tucker, Maîtres et Étudiants écossais de l'université de Bourges. Paris : Champion, 2001. 495 pages.

Références

Naissance en 1500
Décès en septembre 1572
Personnalité politique de la république de Genève au XVIe siècle
Décès dans la république de Genève
Université de Paris
Université de Bourges
Philosophe écossais du XVIe siècle
Diplomate écossais du XVIe siècle
Bibliophile du XVIe siècle
Juriste écossais du XVIe siècle
Personnalité politique genevoise


text:
Q: FancyBox image grouping I am using the latest Fancybox and I am trying to have multiple galleries on one page.  I tried the rel attribute for grouping and the example below.  No matter the photos are not grouping.  I've tried all the recommendations I have seen in the forums to no avail. I tried this snippet as a script in the page and it didn't work either:
$(".fancybox").fancybox();

Any help you can provide would be awesome.

A: This structure using rel like

 Gallery one

Gallery one / image 01
Gallery one / image 02

Gallery two

Gallery two / image 01
Gallery two / image 02

... with this script :

$(document).ready(function() {
  $(".fancybox").fancybox(); // fancybox
}); // ready

... should work!!
Check this JSFIDDLE and compare it with your code.
Also make sure you updated both, js and css fancybox files to the latest version.

A: Removing the following lines from my script.js file allowed the rel attributes to work correctly:
$('.list4>li>figure>a, .list6>li>figure>a').attr('rel','appendix') .prepend('')


text:
Posted inOp-Ed
Ranking Member Adam Schiff: Trump's violation of the JCPOA is a dangerous abdication of responsibility for our nation's security
by Rep. Adam Schiff May 8, 2018
Washington, DC, May 8, 2018 – Today, Rep. Adam Schiff (D-CA), the Ranking Member of the House Permanent Select Committee on Intelligence, released the following statement:
The decision by President Trump to withdraw the United States from the Iran nuclear deal will undermine our national security, increase the prospect of a nuclear Iran or conflict with that nation, and cause other countries to conclude that America does not keep its word. Scuttling an agreement that had halted the Iranian nuclear program and put in place an intrusive regimen of inspections without a credible Plan B is a mistake of historic proportions. The IAEA and our Intelligence Community has repeatedly confirmed that Tehran is in compliance with the deal, and the President takes this action against the appeals of our closest allies, senior members of Congress in both parties, and many of his own advisors. The President's willingness to shatter the international consensus, forged over years of arduous negotiations, on how to constrain Iran's nuclear program only makes sense as part of a campaign to erase his predecessor's legacy, regardless of the consequences to our national security.
When I endorsed the Joint Comprehensive Plan of Action in 2015, I did so fully cognizant of the agreement's limitations, including the degree to which the restrictions on Iran's enrichment of uranium decrease over the duration of the deal. But the deal's virtues always outweighed its shortcomings and, while Tehran could never be trusted, the JCPOA's provisions were drafted with exactly that premise in mind, putting in place an inspections regime that Secretary Mattis recently described as 'robust.' Under monitoring by international inspectors, Iran has eliminated virtually all of its enriched uranium, destroyed the core of its heavy-water reactor, and removed more than 13,000 centrifuges and placed them under international monitoring. All of that hard won process is now in jeopardy.
Iran will be faced with a choice of whether to stay in the deal despite our violation of its terms, or to withdraw and reinstall the centrifuges that have been mothballed since 2015. As we await the Iranian and European response to U.S. withdrawal, there is no question that in taking this action unilaterally, we have isolated ourselves and weakened our credibility on the world stage in a way that will be difficult to repair. Should a subsequent administration seek to achieve a new agreement restricting Iran's nuclear program, why should other nations assume it will persist beyond the next election?
Nor will the damage be confined to the Middle East alone. The Administration's ability to secure a comprehensive and workable deal with North Korea's dictator, Kim Jong-Un, has now become even more difficult. A denuclearization agreement with the North Korean, with its sizable and secretive nuclear arsenal and ICBM capabilities, would have been enormously difficult under any circumstances, but what incentive does Pyongyang now have in signing on to any agreement knowing that the United States could unilaterally renege at any point in this Administration or the next?
In 2015, as Iran's stockpile of enriched uranium grew ever larger, Congress was faced with the choice of approving or disapproving the JCPOA, and we had to consider whether there was any better alternative. We could find none. The sanctions regime that brought Iran to the negotiating table could not be maintained indefinitely, and if there was to be a peaceful route to preventing Iran from racing towards a nuclear arsenal, an international consensus was vital. Listening to President Trump, it is clear that there is no more of an alternative today than there was in 2015, and all the President has to offer is the hope that tough talk will be enough to avert catastrophe. That is not a strategy or a plan, but a dangerous abdication of responsibility for our nation's security.


Through your generous gifts to Lutheran World Relief, you support coffee farmers around the world by helping them improve their coffee crops, business skills, and quality of life.
And now there's another way to directly connect with coffee farmers through Lutheran World Relief.
We're excited to launch LWR Farmers Market Coffee -- a line of coffee sourced directly from farmers participating in LWR coffee projects. Every delicious cup helps transform poor communities that depend on their coffee crop to feed their families. Farmers are given a stable, predictable, and higher price upfront for their beans.
With LWR Farmers Market Coffee, farmers aren't just suppliers of coffee beans, they are partners in the coffee business -- and because this coffee is sourced directly from LWR project participants, you will see the faces and learn the stories of the actual farmers who grow your coffee. And 80 cents of every pound you purchase goes back into LWR projects to benefit more farmers around the world!
LWR is producing Farmers Market Coffee in partnership with THRIVE Farmers, a coffee roaster who shares our passion for helping farmers lift themselves out of poverty, and become self-sufficient and better able to support their families.
These are just a few of the hardworking coffee farmers of the SOPPEXCCA coffee cooperative, in Nicaragua, who grow beans for LWR Farmers Market Coffee. Lutheran World Relief has worked with SOPPEXCCA for several years, helping farmers diversify their crops, use natural resources more efficiently, and improve the quality of their coffee. As a result of this work, supported by gifts from people just like you, farmers now have access to better equipment to process their coffee, knowledge of how to protect their environment, and the ability to grow cocoa in addition to coffee as a means of income.
Thank you for supporting LWR coffee farmers! Take a moment to get to know a few of the farmers who grow the beans for LWR Farmers Market Coffee.


When I came across Twitter, years ago, it first looked like another chat service. But with the ability to interact via SMS, and easy ways to feed tweets into websites and applications, it quickly became a rich ecosystem for exchanging all kinds of status updates. You see metro lines on twitter, announcing disruptions in services.
It seems the days of the free ecosystem are over, and Twitter is joining the Closed Silos Club to monetise my social connections.
Twitter was a platform that was very open for messages coming in and going out through dozens, even hundreds of applications. Together with similar services like Jaiku, and open source versions like identi.ca (Status.net), it looked like the beginning of federated social networks, at least for such status streams.
It could be something like email, or chat via Jabber or IRC: you can communicate with others, regardless of whether you use the same service (Gmail, Hotmail, your own) or tools (Thunderbird, Outlook). And you could contribute to the common infrastructure by setting up your own server.
This ability to contribute to the infrastructure is what is key to the success of the internet. In peer-to-peer applications, this even is made so easy that most people don't even realise they are contributing: BitTorrent, Skype, Spotify, the key to success is that not everything has to go through a central entity.
But over the last months, Twitter has started to focus on "delivering a consistent Twitter experience".
What that means is that I loose. One by one, the connections I made between websites and tools will be terminated.
SMS outside the US was already abandoned years ago.
LinkedIn tried to phrase it nicely when they stopped showing my tweets on my LinkedIn profile.
RSS is being dropped, and OAuth required, so my open source RSS-reader is dropping all support for twitter.
Instead of being the source, it is turning into the sink of status updates on my networked profiles, a place where I dump updates made on other platforms, and where I will (for how long?) mostly interact during conferences.
Twitter introduced "Cards" which look remarkably like Facebook or Google+ status updates. But I don't need another Facebook-style destination (like another Google+ ghost town). What I liked about Twitter was the wide variety of ways to interact. I don't want a company-dictated "consistent Twitter experience", I want to interact around status updates.
As a content publisher, I don't need yet another social graph and more markup language. Or a provider who insists on monitoring everything I and my visitors do.
As if Google would forbid me to forward an email in my Gmail account with anything other than their web client.


We wish to inform you that Italian Legislative Decree no. 196 of 30 June 2003 ("Personal Data Protection Code") safeguards the rights of persons and other data subjects with regard to the processing of personal data. Under the aforementioned legislation, the processing will be based on the principles of correctness, lawfulness and transparency and protection of your privacy and your rights.
If you wish to be removed from our database, send an email to info@fogher.com with a request to be deleted.
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