Through real-world business experience, an adventurous spirit, a passion for people, and an undeniable talent for speaking so others listen and take action, Manley offers focused and functional lessons in all of his world-class programs. Whether your company needs to rock your top line sales, upgrade its communication skills, drive more focus and accountability, or adjust the employee mindset on customer service, Manley delivers in an unforgettable way.
While most organizations leverage Manley as an opening or closing keynote speaker, all programs can be customized and delivered as a breakout, or extended workshop event.
Reaching Your Next Summit is Manley's signature keynote, focused on personal leadership, intentional relationships and peak performance. Attendees will walk away with a renewed sense of focus, commitment and momentum to realize the next level in their life and business.
After facing the same frustrations from the front lines to the executive level for more than 20 years; I believe the answer is in equipping individuals at all levels to think, act and influence as leaders in their environment. Manley's Reaching Your Next Summit Keynote will help equip you to lead on the edge, and realize more in your life and work every day.
Gain 7 leadership strategies that will empower every attendee to stretch their comfort zones and Lead Beyond Their Position.
Attendees will gain tools they can use immediately to develop a leadership mindset that engages, equips and inspires both them and their team members to step up and lead regardless of their title. Expect team members to build relationships and serve beyond vertical and horizontal boundaries in their environment. Collaboration is just the beginning. With more accountability and increased commitment in the 80%, you will see results you can measure.
Do you know what you need to achieve, but get sidetracked by the inevitable storms of life? Staying focused on our goals, making consistent progress, and achieving our vision is a critical professional challenge that we all face.
In this program, Manley will outline a powerful framework that you can execute every day to get immediate results. You can learn how to gain laser focus, no matter what task you're facing, and utilize your momentum in an effective way. Shut out the white noise of the world and keep moving forward!
Not only will you benefit as a leader from the actionable ideas and unique perspectives presented in this program, but your team will also be able to leverage these strategies to boost the value of your organization every day.
Are you building Momentum with every move you make or are you stuck in the storm of chaos, confusion, and miscommunication? Setting goals is the easy part. The real question is: are you and your teams achieving those goals in a satisfying way? Break free from the daily doubts, uncertainties, and mediocrity. There is no better time than now to execute your world-class vision!
In this program, you will gain insights into building a powerful framework to create and maintain momentum. Learn how to move from vision to velocity, stay focused, and get the results you have always wanted.


We provide our students with the most superior and in-depth SAT I English preparatory course, available. We aim to improve the score of each student by at least 200-250 points, using the most advanced and accomplished techniques, strategies, and practice methods available. Furthermore, we believe in providing each student with individual attention and support, thus, our class size is limited. We utilize carefully selected course materials, which we believe are comprehensive and effective. In the past, our students have responded positively to our teaching methods, and have shown significant improvement in their scores.
Our teaching team is composed of the most outstanding academic achievers. They have attended the most prestigious universities in the world and excelled in their academic fields. More importantly, however, they have all mastered the SAT I English test, in their capacity as students and teachers. In addition, the instructors are well versed in our teaching methods and are best placed to implement our techniques and strategies, as they have the necessary teaching experience. Furthermore, they are capable of communicating with students in the most translucent, lucid and unambiguous manner.
We offer students a 12 week course. The length of each course covers all the requisite material but varies in the number of practice SAT I English tests a student can undertake with us. We believe that the numbers of hours that we must dedicate for teaching the course material varies from 30-50 hours, depending on the capabilities of the students in each group. Thus, students must be prepared to undertake extra prep classes in addition to the normal classes.


Dehler boat are made in Germany and are known for build quality and sailing performance.
The company began 40 years ago with the suggestive name Winnetou, which was the first model to be released from the Willi Dehler shipyard. By the end of the production of this boat 400 had been sold and it is now that Willi Dehler persuades his brother Heinz Dehler to join forces. Dehler started to produce boats Varianta, Optima, Delanta, Sprinta, Sprinta DS, Dueta, Dehlya and the production of the Varianta saw some of Germany's first innovations in boat making including the drop keel and removable cabin.
This yacht sleeps 8 in 3 double cabins plus an extra 2 saloon berths making it very spacious. The saloon is fitted with beautiful teak interior with blue upholstery. The double forward facing cabin consists of a V shaped double berth with its own shower sea toilet and wash basin. There are also two twin cabins with storage space and opening portholes. The gallery is equipped with everything you will need for a long haul cruise with a three burner gas stove and oven, with 12v fridge and double sink. There is also another heads compartment aft with sea toilet and hand basin and shower. This Dehler yacht was built with speed, quality, security, and comfort in mind. It can withstand the harshest seas while providing the perfect comfort for all on board. This yacht is a true diamond for all sailing enthusiast.


The FIRST AND ONLY Doors-off tour deep into the heart of the spectacular Kohala Valleys! There is no better way to experience and learn about the geography, history and incomparable lush beauty of Kohala, birthplace of King Kamehameha, than our doors-off tour. Once you're in these valleys, your camera will be the only thing between you and the towering 2500' waterfalls and sheer cliff faces – talk about EPIC SOCIAL MEDIA POSTS!
* Total flight time typically varies from 30-35 minutes.
HOLY _ _ _ _ !!!!!!! I felt like I could just touch the waterfalls in the valley. This tour left me smiling from ear to ear, hands sweaty and breathless 🙂 Doors OFF is the way to see the Valleys!! Thank you, Pete! You are an Amazing Pilot!!!!
The valleys are breath taking and offering the doors off option definitely enhances the tour. Waimea Airport is super convenient and makes check in a breeze. This package is sure to please!!
ABSOLUTELY AMAZING!!!! As you approach the valley area, the Earth just drops out from under the helicopter and it is nothing short of breath-taking. With the doors off, you can see every boulder, rock, plant, water drop off the waterfalls - everything! I had no concept of how spectacularly tall these waterfalls were before actually seeing them in person from the helicopter. Plus, bonus, the drive up to the airport from Hilo was beyond beautiful and the airport itself in Waimea is so pretty with an incredible sweeping vista of 3 mountains behind it, including Mauna Kea with the telescopes on top; I was lucky enough that it was even snow-capped the day I went! All of it was truly an experience you couldn't get any place else in the world - I'm so lucky I go to do this tour!
This flight was incredibly beautiful and exhilarating!! There's no better way to get up close and personal with the gorgeous waterfalls, valleys, and coastline throughout Kohala. The pilot was very knowledgeable and ensured a smooth flight. I highly recommend this tour during your stay on the Big Island.
This tour was spectacular! Wonderful views from the green valleys, waterfalls, coastlines, etc. I would totally recommend this tour.
Breathtaking sceneries of the valleys and waterfalls DOORS OFF! I've lived here my whole life and was still in awe of the beautiful lush valleys and the waterfalls within them. I highly recommend this tour!
This was absolutely stunning! HIGHLY recommended.
ABSOLUTELY AMAZING!!!! As you approach the valley area, the Earth just drops out from under the helicopter and it is nothing short of breath-taking. With the doors off, you can see every boulder, rock, plant, water drop off the waterfalls – everything! I had no concept of how spectacularly tall these waterfalls were before actually seeing them in person from the helicopter. Plus, bonus, the drive up to the airport from Hilo was beyond beautiful and the airport itself in Waimea is so pretty with an incredible sweeping vista of 3 mountains behind it, including Mauna Kea with the telescopes on top; I was lucky enough that it was even snow-capped the day I went! All of it was truly an experience you couldn't get any place else in the world – I'm so lucky I go to do this tour!
This flight was incredibly beautiful and exhilarating!! There's no better way to get up close and personal with the gorgeous waterfalls, valleys, and coastline throughout Kohala. The pilot was very knowledgeable and ensured a smooth flight. I highly recommend this tour during your stay on the Big Island.
Breathtaking sceneries of the valleys and waterfalls DOORS OFF! I've lived here my whole life and was still in awe of the beautiful lush valleys and the waterfalls within them. I highly recommend this tour!


Heavy snow fell on central and western Japan early Saturday as the Meteorological Agency warned of more to come through Sunday.
By midday, as cold air blanketed a large chunk of Honshu, more than 80 cm of snow had blanketed Kuzuryu, Fukui Prefecture, and Wayata, Hiroshima Prefecture, the Meteorological Agency said.
In Shikoku, two men were found in critical condition the same morning in Yoshinogawa, Tokushima Prefecture, after they abandoned their vehicle in deep snow, according to local police.
Nearly 70 cm of snow was recorded in the town of Shirakawa in Gifu. In another part of the mountainous prefecture, deep snow caused vehicles to become stranded on an expressway, and the road had to be closed for several hours.
Up to 80 cm of snow is expected to fall through Sunday morning over a wide area of Honshu facing the Sea of Japan, the agency warned.


Ahoy matey…. get geared up for summer with the Inflatable Pirate Pool. This BPA and pthalate free kiddie pool comes complete with a pirate flag, decorative windows and a cannon. Shiver me timbers, after a soak wrap up with the Pirate Beach Wrap.


When is a Big Mac not a Big Mac OR The day Supermacs 'Beat' McDonald's.
When is a Big Mac not a Big Mac OR The day Supermacs 'Beat' McDonald's.
As the internet goes into full on meltdown about a decision of the EUIPO, Irish national pride is on display in a way not seen by this trademark nerd since Italia '90. Yes, Supermac's beat McDonalds. This is the Mighty Ducks of the Fast Food World.
As I posted yesterday, as things stand this decision changes nothing. Not. One. Thing. That's because McDonald's has a nearly identical trademark in the EU for 'Big Mac' which was registered last year, and which still stands, and hasn't even been challenged yet.
"If you don't use a trademark, you can lose a trademark. McDonald's didn't show they had used it in the last 5 years, so they lost it".
The law across Europe (and most trademark regimes globally) provides that if you don't use your trademark for the goods and services for which it has been registered, then anybody can apply to cancel/revoke that trademark on the basis of non-use. It is also a defence to trademark opposition proceedings and infringement proceedings (where you are entitled to seek use of the mark from the party with the earlier trademark who is opposing your trademark).
The trademark that was revoked is EU Trademark registration number 000062638.
Class 29 – Foods prepared from meat, pork, fish and poultry products, meat sandwiches, fish sandwiches, pork sandwiches, chicken sandwiches, preserved and cooked fruits and vegetables, eggs, cheese, milk, milk preparations, pickles, desserts.
Class 30 – Edible sandwiches, meat sandwiches, pork sandwiches, fish sandwiches, chicken sandwiches, biscuits, bread, cakes, cookies, chocolate, coffee, coffee substitutes, tea, mustard, oatmeal, pastries, sauces, seasonings, sugar.
Class 42 – Services rendered or associated with operating and franchising restaurants and other establishments or facilities engaged in providing food and drink prepared for consumption and for drive- through facilities; preparation of carry-out foods; the designing of such restaurants, establishments and facilities for others; construction planning and construction consulting for restaurants for others.
You could also argue that their description in Classes 29 and 30 are too broad, because Big Macs are not and never been "fish sandwiches, pork sandwiches, chicken sandwiches" nor have they ever been coffee etc. I say you could argue because it's a little bit unclear from the way commas and semi colons are used in the above to draw the lines.
McDonald's simply could not prove they had been using the trademark for these goods/services for the last 5 years, because they haven't been.
The methods and means of proving genuine use of a mark are unlimited. The finding that genuine use has not been proven in the present case is due not to an excessively high standard of proof, but to the fact that the EUTM proprietor chose to restrict the evidence submitted (15/09/2011, T‑427/09, Centrotherm, EU:T:2011:480, § 46). (emphasis added).
Brochures and printouts of advertising posters, in German, French and English, showing, inter alia, 'Big Mac' meat sandwiches; and packaging for sandwiches (boxes); the materials appear to originate from the EUTM proprietor and are dated between 2011 and 2016. The brochures and posters show a sandwich on the menu along with other products, or on its own, and the prices are also provided on some of the materials; other documents appear to be blank menus in which the price can be filled in. The EUTM appears on the submitted material in relation to sandwiches.
Printouts from the websites mcdonalds.de, www.mcdonalds.at, www.mcdonalds.be, www.mcdonalds.cz, www.mcdonalds.dk, www.mcdonalds.es, www.mcdonalds.fi, www.mcdonalds.fr, www.mcdonalds.hu, www.mcdonalds.ie, www.mcdonalds.it, www.mcdonalds.nl, www.mcdonalds.pl, www.mcdonalds.ro, www.mcdonalds.se, www.mcdonalds.si, www.mcdonalds.sk, www.mcdonalds.co.uk, dated between 07/01/2014 and 03/10/2016. They depict a variety of sandwiches, inter alia 'Big Mac' sandwiches, some of which state that they are sandwiches made with beef meat.
In very short summary, the EUIPO found that this evidence wasn't enough to prove use.
The EUIPO itself provides a substantial 86 page document on how they assess the issue of proof of use. They look at all sorts of things including marketing materials, sales figures, and evidence of every size and shape. You have to show 'genuine use' in the course of trade in a substantive part of the EU.
Class 29 – Foods prepared from meat, pork, fish and poultry products, preserved and cooked fruits and vegetables, eggs, cheese, milk, milk preparations, pickles, desserts.
Class 43 – Services rendered or associated with operating and franchising restaurants and other establishments or facilities engaged in providing food and drink for consumption and for drive-through facilities, namely restaurant services, preparation and provision of carry-out food.
Well, here is where the plot thickens…..like a strawberry milkshake…..mmmmm milkshake.
It's been a quite common policy of brands who haven't been using a trademark for a particular good/service and whose 5 years from the date of registration is about to run out (leaving the mark open to applications for revocation and cancellation) to apply again, for the same mark, for the same goods and services. Why? Because then they have 5 years from the date of that second registration to use the trademark again. Sometimes to keep up appearances, the application will be slightly different from the one that went before, sometimes it's identical.
This has given raise to the question about whether such registrations are made in 'bad faith' or whether there was a 'genuine intent to use' when they were applied for. The logic goes that the only reason for the second application is to stop someone applying to revoke the first application after 5 years.
There isn't a huge amount of caselaw on the question, but it's becoming an increasingly talked about issue and topic.
Here, specifically, Supermac's applied to revoke McDonald's 'Big Mac' trademark on 11 April,2017.
McDonald's applied for its new Big Mac trademark 6 months later on 6 October, 2017.
But we're a long way off that yet.
To put it in context, in my view, it's the difference between Connaught beating the All Blacks in a friendly where nothing much was riding on it and Ireland beating the All Blacks in the World Cup. A win is a win, but some matter more than others.
McDonald's International Property Company, Ltd., 2711 Centerville Road, Suite 400, Wilmington, DE 19808, United States of America (EUTM proprietor), represented by Bardehle Pagenberg Partnerschaft mbB Patentanwälte, Rechtsanwälte, Prinzregentenplatz 7, 81675 Munich, Germany (professional representative).
The application for revocation is upheld.
The EUTM proprietor's rights in respect of European Union trade mark No 62 638 are revoked in their entirety as from 11/04/2017.
The EUTM proprietor bears the costs, fixed at EUR 1 080.
The applicant invoked Article 58(1)(a) EUTMR.
The applicant argues that the EUTM was not put to genuine use during a continuous period of five years following the date of registration in relation to any of the registered goods and services. The applicant requests that the EUTM be revoked in its entirety with an earlier date, namely five years from the date of registration.
In response to the application for revocation, the EUTM proprietor filed evidence of use, which is listed below in the following section of the present decision. The EUTM proprietor claims that the EUTM is used in a number of Member States. It also states that the submitted evidence shows that the mark has been used in advertising and on the packaging of the goods that have been marketed. It is also claimed that 'as commonly known and attested to in the affidavits' millions of products were sold under the EUTM. The EUTM proprietor finally concluded that if the Office considers the evidence to be insufficient to show genuine use for all of the contested goods and services, then the application for revocation has to be rejected at least in so far as it is directed against some of the goods and services (which it listed explicitly).
The applicant argued that the evidence of use submitted by the EUTM proprietor is insufficient to prove that the EUTM was put to genuine use for anything other than sandwiches and it analyses the pieces of evidence individually. It concludes that the application must be upheld.
The EUTM proprietor in its rejoinder states that the use of the EUTM in Germany, France and the United Kingdom, which are three of the economically most important Member States is sufficient to prove that the mark is used in the European Union. It further claims that the use of the mark for a sandwich shall also be considered as use for its ingredients.
According to Article 58(1)(a) EUTMR, the rights of the proprietor of the European Union trade mark will be revoked on application to the Office, if, within a continuous period of five years, the trade mark has not been put to genuine use in the Union for the goods or services for which it is registered, and there are no proper reasons for non-use.
Genuine use of a trade mark exists where the mark is used in accordance with its essential function, which is to guarantee the identity of the origin of the goods or services for which it is registered, in order to create or preserve an outlet for those goods or services. Genuine use requires actual use on the market of the registered goods and services and does not include token use for the sole purpose of preserving the rights conferred by the mark, nor use which is solely internal (11/03/2003, C‑40/01, Minimax, EU:C:2003:145, in particular § 35-37, 43).
When assessing whether use of the trade mark is genuine, regard must be had to all the facts and circumstances relevant to establishing whether commercial exploitation of the mark is real, particularly whether such use is viewed as warranted in the economic sector concerned to maintain or create a market share for the goods or services protected by the mark (11/03/2003, C‑40/01, Minimax, EU:C:2003:145, § 38). However, the purpose of the provision requiring that the earlier mark must have been genuinely used 'is not to assess commercial success or to review the economic strategy of an undertaking, nor is it intended to restrict trade-mark protection to the case where large-scale commercial use has been made of the marks' (08/07/2004, T‑203/02, Vitafruit, EU:T:2004:225, § 38).
According to Article 19(1) EUTMDR in conjunction with Article 10(3) EUTMDR, the indications and evidence of use must establish the place, time, extent and nature of use of the contested trade mark for the goods and/or services for which it is registered.
In revocation proceedings based on the grounds of non-use, the burden of proof lies with the EUTM proprietor as the applicant cannot be expected to prove a negative fact, namely that the mark has not been used during a continuous period of five years. Therefore, it is the EUTM proprietor who must prove genuine use within the European Union, or submit proper reasons for non‑use.
In the present case, the EUTM was registered on 22/12/1998. The revocation request was filed on 11/04/2017. Therefore, the EUTM had been registered for more than five years at the date of the filing of the request. The EUTM proprietor had to prove genuine use of the contested EUTM during the five-year period preceding the date of the revocation request, that is, from 11/04/2012 to 10/04/2017 inclusive, for the contested goods and services listed in the section 'Reasons' above.
On 25/09/2017 the EUTM proprietor submitted evidence as proof of use.
A printout from en.wikipedia.org, providing information on 'Big Mac' hamburger, its history, content and nutritional values in different countries.
Having examined the material listed above in its entirety, the Cancellation Division finds that the evidence is insufficient to establish genuine use of the trade mark.
Although some of the printouts of the proprietor's web pages exhibit sandwiches (the prices are not provided), some of which marked with the EUTM, it could not be concluded whether, or how, a purchase could be made or an order could be placed. Even if the websites provided such an option, there is no information of a single order being placed. Therefore, a connection between the EUTM proprietor's websites (irrespective of the used country code top-level domains and languages) and the eventual number of items offered (sold) could not be established.
Assessment of the relevance, pertinence, conclusiveness and efficacy of evidence lies within the discretion and power of judgment of the Office, not the parties, and falls outside the adversarial principle which governs inter parties proceedings (decisions of 01/08/2007, R 201/2006-4, OCB, § 19;14/11/2000, R 823/1999-3, SIDOL).
A declaration by the applicant concluding that evidence of use submitted is sufficient to prove use in relation to the contested goods does not, therefore, have any effect on the Office's findings.
It follows, that an overall assessment of the evidence does not allow the conclusion, without resorting to probabilities and presumptions, that the mark was genuinely used during the relevant period for the relevant goods or services (15/09/2011, T‑427/09, Centrotherm, EU:T:2011:480, § 43). It is up to the EUTM proprietor to show such use in a manner which allows a reasoned conclusion to be made that the use is not merely token.
The methods and means of proving genuine use of a mark are unlimited. The finding that genuine use has not been proven in the present case is due not to an excessively high standard of proof, but to the fact that the EUTM proprietor chose to restrict the evidence submitted (15/09/2011, T‑427/09, Centrotherm, EU:T:2011:480, § 46).
Considering the above, the Cancellation Division concludes that the evidence furnished by the EUTM proprietor is insufficient to prove that the EUTM was genuinely used in the relevant territory during the relevant period of time.
The factors of time, place, extent and nature of use are cumulative (05/10/2010, T-92/09, STRATEGI, EU:T:2010:424, § 43). This means that the evidence must provide sufficient indication of all of these factors in order to prove genuine use. Failure to fulfil one of the conditions will lead to the evidence of use being rejected as insufficient and, as at least the extent of use has not been established, it is not necessary to enter into the other requisites.
It follows from the above that the EUTM proprietor has not proven genuine use of the contested EUTM for any of the goods and services for which it is registered. As a result, the application for revocation is wholly successful and the contested EUTM must be revoked in its entirety.
According to Article 62(1) EUTMR, the revocation will take effect from the date of the application for revocation, that is, as of 11/04/2017. An earlier date, on which one of the grounds for revocation occurred, may be fixed at the request of one of the parties. In the present case, the applicant has requested an earlier date. However, in exercising its discretion in this regard, the Cancellation Division considers that it is not expedient in this case to grant this request, since the applicant has not shown any legal interest to justify it.
According to Article 109(1) EUTMR, the losing party in cancellation proceedings must bear the fees and costs incurred by the other party.
Since the EUTM proprietor is the losing party, it must bear the cancellation fee as well as the costs incurred by the applicant in the course of these proceedings.
According to Article 109(1) and (7) EUTMR and Article 18(1)(c)(ii) EUTMIR, the costs to be paid to the applicant are the cancellation fee and the representation costs, which are to be fixed on the basis of the maximum rate set therein.
According to Article 67 EUTMR, any party adversely affected by this decision has a right to appeal against this decision. According to Article 68 EUTMR, notice of appeal must be filed in writing at the Office within two months of the date of notification of this decision. It must be filed in the language of the proceedings in which the decision subject to appeal was taken. Furthermore, a written statement of the grounds of appeal must be filed within four months of the same date. The notice of appeal will be deemed to be filed only when the appeal fee of EUR 720 has been paid.


True success is not in what you accomplish; it is in doing what God told you to do. That is why people who build big projects or gain great fame can be successful and depressed at the same time.
Going against your purpose may be a personal issue, but it is never a private one. You can mess up others' lives if you aren't supposed to be where you are, or if you are supposed to be somewhere that you refuse to go.
Remember the story of Jonah in the Bible? God told him that his purpose was to go to Nineveh to warn the people there to turn to God. Jonah's response was, in effect, "I'm not going!" He got on a ship headed for Tarshish instead. God had purposed that Jonah would go to Nineveh even before the prophet was born.
I urge you not to board the wrong ship, but to remain on course in God's purpose.
Father, please help me to stay on course with You. I don't want to drift to the right or to the left, but to continue to follow Your direction.
Thought: Until you follow God's dream, you will be unfulfilled.
Next articleWhat Is The Danger Of Global Blasphemy Laws?


text:
body processes
cosmetics and wellness
Leriche syndrome
Minerals (minerals)
Minerals, mineral salts and minerals are salt-like substances of the earth's crust. They always consist of a connection between a metal and a nonmetal. In the field of tension of this contrast arise the typical characteristics of minerals: All minerals are crystals and dissolve in water as so-called ions, which have electrical properties
Lincomycin is an antibiotic approved in Germany only for use in veterinary medicine. It is especially effective against gram-positive bacteria. In the US and Canada, it is also approved for the treatment of humans. What is Lincomycin? Lincomycin (Chemical Molecular Formula: C18H34N2O6S) is a class of antibiotics drug
cardiac defect
A heart defect or heart is a common name for disorders of the structure and structure of the heart. A distinction is made between heart defects in acquired heart defects (eg due to infections or heart diseases) and congenital heart defects. In congenital heart defects are usually cardiac malformations that can be discovered and treated already in the womb or the newborn
Auxiliaratmung
Auxiliary respiration (auxiliare lat. = To help) is characterized in that the respiratory aid musculature is switched on in order to adapt the respiratory movements to the needs and to improve the lung function. What is the auxiliary breathing? The respiratory aid muscles are switched on to adjust the respiratory movements to the needs and to improve the lung function
The lips represent an important organ of the human body, which performs important tasks and functions in everyday life. At the same time, however, they may also be affected by diseases or may point to specific diseases by exhibiting certain symptoms. What are lips? Among the lips, which are also referred to in the medical jargon as labium oris, one understands the soft tissue folds to be found in the lower part of the face
occlusal
In medicine, various types of so-called occlusion films are used. For example, the ophthalmologist uses occlusion films to treat double images and to the dentist they are diagnostic tools. The ophthalmological occlusion foil is a pleasant and gentle alternative to the conventional eye patch. What is the occlusion foil
Retinitis pigmentosa is a genetic degeneration of the retina that gradually breaks down the photoreceptors of the eyes, usually leading to complete blindness in the late course of the disease. Often, this phenomenon is only one symptom of several and, together with the accompanying symptoms, forms a whole complex of symptoms, such as the Usher or Alport syndrome
Editorial Recommends
The postponement of work, such as the unpopular tax return, is a well-known everyday phenomenon. However, if the elimination of unpleasant but necessary work is chronically postponed, the procrastination is a serious work-related disorder. Those affected often end up in a vicious circle of self-doubt, pressure and fear of failure, while outsiders misinterpret the symptoms as laziness
Cushing syndrome (hypercortisolism)
Cushing syndrome or hypercortisolism is a condition caused by an elevated cortisol level in the body. It goes hand in hand with various clearly visible changes in appearance and with bodily dysfunction. The Cushing syndrome needs to be treated as it progresses and becomes life-threatening without therapy
mucosectomy
Mucosectomy is an endoscopic procedure used in early-stage cancer that minimally invasively removes tumorous mucous membranes. Most often, the mucosectomy is performed as part of a colonoscopy. The procedure is approximately a standard procedure in Germany and has a complication rate of only more than 1: 1000 to 1: 5000
contused
Quetschwunden can have many "faces" and unfortunately occur quite frequently. Mostly, they are noticeable by pain and bluish-red discoloration and swelling of the skin. However, a breast sore may also be exposed and therefore even bleed and may require the need for the fastest possible medical care
Home anatomy
Aryepiglotticus muscle
The aryepiglotticus muscle is a special muscle that is usually counted among the muscles of the larynx. The aryepiglotticus muscle is comparatively small and shallow. In principle, it is one of the inner muscles of the larynx area.
What is the muscular aryepiglotticus?
The muscular aryepiglotticus belongs to the so-called laryngeal musculature. Specifically, the muscle is located in the inner region of the laryngeal muscles. As a rule, it is a relatively small and tender muscle.
The aryepiglotticus muscle originates from the upper area of the so-called arytenoid cartilage. This cartilage is commonly referred to in medical terminology as Cartilago arytaenoidea. In its further course, the aryepiglotticus muscle moves to the so-called plica aryepiglottica. This is located on the lateral portion of the epiglottis. In principle, the aryepiglotticus muscle continues the arytaenoideus obliquus muscle.
Anatomy & Construction
The aryepiglotticus muscle is located near the human larynx. Because the aryepiglotticus muscle is an essential element of the internal muscles of the larynx. For this reason, the aryepiglotticus muscle is located in the front of the neck. The size of the aryepiglotticus muscle is comparatively small. In addition, the muscle is relatively thin and narrow in shape.
The aryepiglotticus muscle is usually innervated by two special nerves. These two nerves are on the one hand the so-called inferior laryngeal nerve and the recurrent laryngeal nerve. It should be noted that the laryngeal nerve originates from the recurrent laryngeal nerve. Basically, the aryepiglotticus muscle is closely related to numerous other muscles of the laryngeal muscles. Disturbances in the sensitive system of the laryngeal musculature, for example, impair the voice of the affected persons. The respective complaints are noticeable in individual cases by a variety of typical symptoms.
Function & Tasks
The aryepiglotticus muscle performs various important functions and functions in connection with the internal musculature of the larynx. In this way, the aryepiglotticus muscle contributes to the functioning of the vocal tract. Basically, the aryepiglotticus muscle causes a narrowing at the beginning of the larynx. This area is called with medical terminology Aditus laryngis. In addition, the aryepiglotticus muscle promotes the usual movements of the epiglottis in a certain direction.
Basically, the most important functions of the muscular aryepiglotticus are on the one hand in the so-called Deglutation and on the other hand in the phonation. Deglutation is primarily the process of swallowing, such as saliva or food. As part of the laryngeal elevation during swallowing, the epiglottis is lowered, moving over the entrance of the larynx. This process comes in particular by two triggers to conditions. On the one hand, the reason for the tongue shifts to the back during the swallowing process. On the other side, the thyrohyoid muscle contracts. Special fibers of the muscular aryepiglotticus cause the vestibule of the larynx to narrow. In addition, the epiglottis and the arytenoids move towards each other.
Also in connection with phonation the aryepiglotticus muscle plays an important role. Here, the aryepiglotticus muscle performs important tasks in the anterior tension chain. It is an arrangement of certain muscles that together make for a narrowing and closing of the so-called vocal tract. As the epiglottis and the arytenoids approach each other, the vocal folds shorten. In this way, the effect of the vocalis muscle is weakened. In addition, the effect of the cricothyroid muscle is increasing.
To compensate for this, it is necessary for the vocalis muscle to regulate both the voice frequency and the volume. To do so, the muscle would have to make enormous efforts. As a result, under certain circumstances, a so-called oval Glottisspalt forms. The narrowing of the vestibule is required for certain types of chants. The narrowing effect of the muscular aryepiglotticus is necessary, for example, when singing with a loud voice.
In connection with the muscular aryepiglotticus, various clinical pictures and complaints are possible, which in some persons result in certain circumstances.
Since the aryepiglotticus muscle is an integral part of the internal muscles of the larynx, injury or impairment of any other kind adversely affects the voice of the affected person. Because the larynx represents the most important vocal organ of the human organism. Disturbances in the sensitive interaction of the individual muscles and nerves, which are in the area of the larynx, possibly lead to considerable difficulties of the voice.
Apart from the immediate effect on the voice in case of impairment of the aryepiglotticus muscle, disorders of the muscle may also cause problems with the swallowing process. For in the process of swallowing, the aryepiglotticus muscle takes over essential tasks in the area of the larynx. In principle, all complaints in connection with the laryngeal musculature should be clarified by a suitable doctor as soon as possible.
Because an exact diagnosis and a timely treatment remain, sometimes cause chronic discomfort to the muscles of the larynx. The complex interaction of the laryngeal musculature and the aryepiglotticus muscle must be protected in the event of illness by adequate therapy measures and protection of the voice.
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Heterocyclic compounds -- Derivatives
1Lee, Yi-Chen 1Molefe, Duduzile Mabel 1Nocanda, Xolani Wittleton 1Nyoni, Dubekile 1Pakade, Vusumzi Emmanuel 1Rashamuse, Thompho Jason 1Rose, Nathan Rolf
3HIV (Viruses) 3HIV infections -- Treatment 3Protease Inhibitors 2AIDS (Disease) -- Treatment 2Coumarins 2Quinoline 1AIDS (Disease) 1Chemical inhibitors 1Chemical kinetics 1Enzyme inhibitors 1HIV infections 1Heterocyclic chemistry 1Nuclear magnetic resonance 1Nuclear magnetic resonance spectroscopy 1Proteolytic enzymes
5MSc 5Masters 2Doctoral 2PhD
CDDate
Applications of Baylis-Idllman methodology in the synthesis of chromene derivatives
Authors: Nocanda, Xolani Wittleton
Subjects: Heterocyclic chemistry , Heterocyclic compounds -- Derivatives
Type: Thesis , Doctoral , PhD
Identifier: vital:4556 , http://hdl.handle.net/10962/d1018257
Description: The reaction of salicylaldehyde with various activated alkenes, viz., methyl vinyl ketone, ethyl vinyl ketone, phenyl vinyl sulfone, phenyl vinylsulfonate, acrolein and acrylonitrile, under Baylis-Hillman conditions, has been found to proceed with the chemoselective formation of chromene derivatives. The reaction conditions have been optimised and chromene derivatives have been obtained in isolated yields up to 87 %. The generality of the reaction, using 1,4-diazabicyclo[2.2.2]octane (DABCO), as the catalyst, and a heterogeneous (chloroform-water) solvent system, has been established using a range of salicylaldehyde derivatives,. including 2-hydroxynaphthaldehyde. The formation of chromene derivatives, under these conditions, has been assumed to proceed via an initial, Baylis-Hillman reaction, followed by cyclisation involving intramolecular conjugate addition, and subsequent dehydration. Evidence supporting this sequence has been obtained from the isolation ofBaylis-Hillman products from reactions involving the use of tertbutylclimethylsilyl-protected salicylaldehyde, 4-hydroxybenzaldehyde and tert-butyl acrylate as substrates. The potential of the ''Baylis-Hillman zwitterion" to participate as a donor species in Michael-type addition reactions has been explored and a series of climeric products has been isolated. The Baylis-Hillman methodology has also been successfully extended to the synthesis of sulfurcontaining heterocyclic systems, and a range of 3-substituted thiochromenes has been obtained in moderate yields, using 2,2'-dithiobenzaldehyde and various activated alkenes in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as catalyst. The electron-impact mass spectra of selected chromene and thiocbromene derivatives have been investigated permitting comparison of the fragmentation of the oxygen- and sulfur-containing analogues. In a study directed at the synthesis of potential HIV -1 protease inhibitors, chromene- and thiocbromene-containing analogues of the clinically useful drug, ritonavir, have been prepared. Thiochromene and chromene derivatives were converted to the corresponding 3 -carboxylic acids and coupled with a specially prepared, hydroxyethylene dipeptide isostere to afford ritonavir analogues containing cbromene and thiochromene termini in ca. 60% yield.
Date Issued: 2001
Application of the Baylis-Hillman reaction in the preparation of quinoline derivatives
Authors: Pakade, Vusumzi Emmanuel
Date: 2006 , 2013-06-11
Subjects: Heterocyclic compounds -- Derivatives , Quinoline
Type: Thesis , Masters , MSc
Identifier: vital:4442 , http://hdl.handle.net/10962/d1007669 , Heterocyclic compounds -- Derivatives , Quinoline
Description: The reaction of various 2-nitrobenzaldehyde derivatives with methyl vinyl ketone (MVK) in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO) has afforded the Baylis-Hillman adducts in moderate to good yield. Dissolution of the catalyst in the solvent before the addition of the aldehyde was observed to improve the yield. Reduction of the Baylis-Hillman adducts was effected by catalytic hydrogenation using a 10% palladium-on- carbon catalyst in ethanol to give quinoline and quinoline-N-oxide derivatives and, in some cases, acyclic reduction products. All products were characterised using NMR and, where appropriate, HRMS methods. Selected quinoline-N-oxides were successfully converted to their corresponding quinoline derivatives using phosphorus tribromide (PBr₃) and DMF as solvent. Conjugate addition of the benzylamine and piperidine nucleophiles to the Baylis-Hillman adducts was also investigated but proved problematic, with one of the substrates undergoing a retro-Baylis-Hillman reaction to afford the aldehyde in ca. 40% yield, but seemingly only traces of the required product. Perkin-type coupling of two 2-methylquinolines with benzaldehyde was successfully effected to afford the desired styrylquinoline derivatives confirming the potential of the Baylis-Hillman approach to the construction of the analogues of known HIV-1 integrase inhibitors. Three ¹³C NMR chemical shift prediction programmes, viz., Chem Window, neural network and HOSE (hierarchically ordered spherical description of environment) methods were applied to selected representative compounds prepared in the project. The results from the three programmes correlated reasonably well with the experimental carbon-13 chemical shift data for each of the selected compounds.
Synthesis of novel coumarin derivatives as potential inhibitors of HIV-1 protease
Authors: Rose, Nathan Rolf
Subjects: Coumarins , Protease Inhibitors , Heterocyclic compounds -- Derivatives , HIV infections -- Treatment
Identifier: vital:4430 , http://hdl.handle.net/10962/d1007220 , Coumarins , Protease Inhibitors , Heterocyclic compounds -- Derivatives , HIV infections -- Treatment
Description: This research has focused on the development of novel coumann derivatives containing peptide-like side chains as potential HIV-1 protease inhibitors. The reaction of various salicylaldehyde derivatives with tert-butyl acrylate In the presence of 1,4- diazabicyclo[2.2.2]octane (DABCO) has afforded a series of Baylis-Hillman adducts in moderate yield. Cyclisation of the adducts in the presence of HCI afforded the corresponding 3-(chloromethyl)coumarin derivatives, which have been reacted with various amine hydrochlorides in the presence of Proton Sponge® to afford a series of novel 3- (aminomethyl)coumarin derivatives, which were fully characterised by NMR and HRMS methods. Various approaches to the introduction of hydroxyl or amino groups at the C-4 position of coumarin and the 3-(chloromethyl)coumarin derivatives have been explored; these have included dihydroxylation of the coumarin double bond, and the synthesis of 4- benzylaminocoumarin derivatives as potential intermediates. The Vilsmeier-Haack and Mannich reactions have also been investigated as possible methods of introducing the desired peptide-like functionality. Computer modelling of selected structures has indicated that some of the novel 3- (aminomethyl)coumarin derivatives may exhibit activity as inhibitors of HIV-1 protease. The planned enzyme inhibition assays were unfortunately precluded by the aqueous insolubility of the selected compounds. Three ¹³C NMR chemical shift algorithms, viz., Modgraph Neural Network, Modgraph HOSE and Chern Window, have been applied to selected compounds prepared in this study. The Modgraph Neural Network algorithm was found, in all cases, to provide the most accurate correlations with the experimentally-determined chemical shifts. , KMBT_363 , Adobe Acrobat 9.54 Paper Capture Plug-in
Application of the Baylis-Hillman methodology in the construction of novel heterocyclic derivatives
Authors: Nyoni, Dubekile
Subjects: Heterocyclic compounds -- Derivatives
Description: Baylis-Hillman reactions of 2,2'-dithiodibenzaldehyde with the acyclic alkenes, methyl vinyl ketone (MVK) and methyl acrylate have afforded the thiochromene derivatives in moderate yields, and this approach has been extended to the use of the cyclic alkenes, 2-cyclohexenone and 2-cyclopentenone to afford the tricyclic analogues. In all cases, reduction of the disulphide link and intramolecular cyclisation occurred in situ, and a preliminary kinetic study of this reaction using the acyclic substrates MVK and methyl acrylate was undertaken with the aim of elucidating the mechanism involved. The results obtained showed that the consumption of both 2,2'-dithiodibenzaldehyde and MVK and/or methyl acrylate followed 1st-order kinetics during the initial stages of the reaction, but then deviated from 1st-order linearity. The reaction with methyl acrylate was much slower than with MVK, and the kinetic data indicates the mechanism to be more complex than anticipated. Conjugate addition reactions of methyl acrylate-derived 2-nitrobenzaldehyde Baylis-Hillman adducts with the amines, piperidine and benzylamine, afforded a range of conjugate addition products as diastereomeric mixtures in excellent yield (80-100%). Catalytic hydrogenation of the conjugate addition products using a Pd-C catalyst in ethanol, has afforded the corresponding, novel 3-amino-2-quinolone derivatives in lower yield (22-37%).The application of [superscript 13]C NMR prediction programmes to selected compounds synthesized in this study has revealed reasonable correlations between the experimental and predicted values.
Studies directed towards the synthesis of chromone carbaldehyde-derived HIV-1 protease inhibitors
Authors: Molefe, Duduzile Mabel
Subjects: Protease Inhibitors , HIV infections , HIV (Viruses) , AIDS (Disease) , Proteolytic enzymes , Heterocyclic compounds -- Derivatives , Chemical kinetics , Nuclear magnetic resonance spectroscopy
Description: A series of chromone-3-carbaldehydes have been prepared using Vilsmeier-Haack methodology while a corresponding series of chromone-2-carbaldeydes have been synthesized via the Kostanecki-Robinson reaction. Baylis-Hillman reactions have been conducted on both series of chromone carbaldehydes using three different catalysts, viz., 1,4-diazabicyclo(2.2.2]octane (DABCO), 1,8-diazabicyclo[5.4.0]undec- 7-ene (DBU) and 3-hydroxyquinuclidine (3HQ), and acrylonitrile, methyl acrylate and methyl vinyl ketone as the activated alkenes. These reactions have typically (but not always!) afforded both normal Baylis-Hillman and dimeric products. Attention has also been given to the use of 1-methyl-2-pyrrolidine (1-NMP), an ionic liquid, to replace normal organic solvents, and it has been found that, in the presence of DABCO, chromone-3-carbaldehydes afford the dimeric products alone. Reactions of chromone-3-carbaldehydes with methyl vinyl ketone have yielded unexpected, novel adducts, which appear to arise from preferential attack at C(2) in the chromone nucleus. Research on chromone-2-carbaldeydes under Baylis-Hillman conditions has also resulted in the formation of some interesting products instead of the expected Baylis-Hillman adducts. The Baylis-Hillman products have been explored as substrates for aza-Michael reactions using various amino derivatives including protected amino acids in the presence of the tetrabutylammonium bromide (TBAB) and the ionic liquid, 3-butyl-1- methylimidazoleboranetetrafluoride (BmimBF₄), as catalysts. The aza-Michael products have been targeted as truncated ritonavir analogues for investigation as potential HIV -1 protease inhibitors, and representative compounds have been subjected to enzyme inhibition assays to explore the extent and type of inhibition. Lineweaver-Burk and Dixon plots have indicated competitive inhibition in one case as well as non-competitive inhibition in another, and the inhibition constants (Ki) have been compared with that of the ritonavir. Computer modelling studies have also been conducted on selected chromonecontaining derivatives, using the ACCELRYS Cerius² platform. Interactive docking of the chromone-containing ligands into the HIV -1 protease receptor site, using the Ligandfit module, has indicated the importance of hydrogen-bonding interactions mediated by bridging water molecules situated in the receptor cavity. NMR spectroscopy has been used to elucidate complex and competing mechanistic pathways involved in the Baylis-Hillman reactions of selected 2-nitrobenzaldehydes with MVK in the presence of DABCO - reactions which afford the normal BaylisHillman product, the MVK dimer and syn- and anti-Baylis-Hillman type diadducts. The kinetic data confirm the concomitant operation of two pathways and reveal that, in the initial stage of the reaction, the product distribution is kinetically controlled, whereas in the latter stage, thermodynamic control results in the consumption of the normal Baylis-Hillman product and predominance of the anti-diadduct.
Studies towards the synthesis of novel, coumarin-based HIV-1 protease inhibitors
Authors: Rashamuse, Thompho Jason
Subjects: Coumarins , Protease Inhibitors , HIV infections -- Treatment , HIV (Viruses) , AIDS (Disease) -- Treatment , Heterocyclic compounds -- Derivatives
Identifier: vital:4359 , http://hdl.handle.net/10962/d1005024 , Coumarins , Protease Inhibitors , HIV infections -- Treatment , HIV (Viruses) , AIDS (Disease) -- Treatment , Heterocyclic compounds -- Derivatives
Description: A series of the Baylis-Hillman adducts have been obtained by reacting protected O-benzylated and unprotected substituted salicylaldehydes with methyl acrylate or tertbutyl acrylate, respectively, using DABCO as catalyst. Treatment of the Baylis-Hillman adducts with HCl in a mixture of acetic acid and acetic anhydride afforded the corresponding 3-(chloromethyl)coumarin derivatives with yields of up to 94%. Similar use of HI afforded the corresponding 3-(iodomethyl)coumarins but, depending on the reaction time, the reduced 3-methyl analogues could also be obtained. Arbuzov reactions of the 3-(halomethyl)coumarin derivatives have been undertaken to afford 4-phosphorylated and 1'-phosphorylated derivatives, regioselectivity being dependent on the halide-leaving group. The 3-(chloromethyl)coumarin derivatives have been subjected to nucleophilic (SN) attack by benzylamine to give the corresponding 3- [(benzylamino)methyl]coumarin derivatives in yields of up to 74%. Further treatment of the 3-[(benzylamino)methyl]coumarin derivatives with chloroacetyl chloride afforded the chloroacetamide derivatives, which exhibit hindered rotation about the amine C(O)-N bond. The acetamide derivatives have also been subjected to Arbuzov reaction conditions to afford the phosphorylated derivatives in yields of up to 86%. In a preliminary modelling study, hydrolysed analogues of the synthesized phosphorylated derivatives have been docked into the active site of the HIV-1 protease enzyme using the Cerius-2 Ligandfit software module to provide an insight into potential receptor-ligand hydrogen bonding interactions.
Studies towards the development of novel HIV-1 integrase inhibitors
Authors: Lee, Yi-Chen
Subjects: HIV infections -- Treatment , HIV (Viruses) , AIDS (Disease) -- Treatment , Nuclear magnetic resonance , Heterocyclic compounds -- Derivatives , Enzyme inhibitors , Chemical inhibitors , Quinoline
Identifier: vital:4357 , http://hdl.handle.net/10962/d1005022 , HIV infections -- Treatment , HIV (Viruses) , AIDS (Disease) -- Treatment , Nuclear magnetic resonance , Heterocyclic compounds -- Derivatives , Enzyme inhibitors , Chemical inhibitors , Quinoline
Description: The project has focused on the preparation of several series of compounds designed as potential HIV-1 integrase inhibitors. Various 2-nitrobenzaldehydes have been reacted with two activated alkenes, methyl vinyl ketone (MVK) and methyl acrylate, under Baylis-Hillman conditions to afford α-methylene-β-hydroxylalkyl derivatives in moderate to excellent yields. The reactions were conducted using the tertiary amine catalysts, 1,4-diazabicyclo[2.2.2]octane(DABCO) or 3-hydroxyquinuclidine (3-HQ) with chloroform as solvent, and yields were optimised by varying the catalyst, reagent concentrations and the reaction time. Reductive cyclization of the Baylis-Hillman adducts via catalytic hydrogenation, using 10% palladiumon-carbon catalyst in ethanol, afforded quinoline and quinoline N-oxide derivatives. In some cases "acyclic" reduction products were also isolated. Reaction of the Baylis-Hillman MVK adducts with HCl, has resulted in effective nucleophilic (SN') displacement of the hydroxyl group to afford allylic chloride derivatives. Direct substitution of these chloro derivatives by secondary or primary amines, followed by catalytic hydrogenation gave quinoline derivatives containing a 3-aminomethyl substituent. The Baylis-Hillman ester adducts obtained from reaction with methyl acrylate were treated directly with various amines to give diastereomeric conjugate addition products. Reactions with piperazine gave N,N'-disubstituted piperazine products. The piperidine derivatives have been dehydrated to give cinnamate esters in moderate yields. The products, which have all been satisfactorily characterised by elemental (HRMS) and spectroscopic (1- and 2-D NMR) analysis, constitute a "library" of compounds for in silico and in vitro studies as potential HIV integrase inhibitors.


text:
Q: Starting AWS Serverless Framework can't install starter sample I want to run the serverless framework for use with my AWS solution.
But the sample starter is not installing properly, why?
$serverless project install serverless-starter

/usr/local/lib/node_modules/serverless/bin/serverless:5
let argv = require('minimist')(process.argv.slice(2));
^^^
SyntaxError: Unexpected strict mode reserved word
at exports.runInThisContext (vm.js:73:16)
at Module._compile (module.js:443:25)
at Object.Module._extensions..js (module.js:478:10)
at Module.load (module.js:355:32)
at Function.Module._load (module.js:310:12)
at Function.Module.runMain (module.js:501:10)
at startup (node.js:129:16)
at node.js:814:3

A: As solved in comments, the issue occurred when a old Node version was used and Serverless requires Node version 4.x or greater.
In this case, the let declaration was not recognized because it's a ES6 specification and support started only in Node 4 (Kangax table).

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The greatest problem confronting many children beginning school is the absurdity that having something to say is insufficient grounds for saying it. Sounds stupid? Yes. Having been "wired for sound" (Chomsky) and having learnt the rules for speech-survival at home, children are confronted with the restriction of mankind's oddest invention - literacy.
Children entering the world of school literacy are usually moving from a largely listening/speaking environment through a rapid, sometimes hostile and demanding transition towards reading/writing. And, as we know, dislocation caused by the move is lessened when a supportive home environment has provided experience with reading and writing. Nevertheless, the level of support required for transition to literacy remains high.
This brief article looks at the progress made by Natasha (grade 1) in telling her story within the conventions of school literacy and explores the role of the teacher in supporting Natasha's developing literacy.
Having attended kindergarten last year, Natasha is now in prep. grade in Victoria, Australia. She is a bright and well coordinated child with an active interest in stories but she is not progressing as well in writing as many of her peers. Natasha's latest story is transcribed below with the spelling as it was written.
There ones was a feringnshesr her name was Sealt She lived in a little house.
At first reading, the story remains a mystery. What is a feringnshesr?
A second reading fails to provide many further clues. Clearly, it is time to conference with Natasha. But what form should the conference take? Natasha already knows that she has a problem and a word-by-word interrogation of the story will indicate to her that she has failed again.
So let us return to the beginning, to Natasha's intention. She set out to write a story. The story she has written is reasonably complex, involving a feringnshesr which has a name, lives in a house, gets sick and, in consequence,"cantat" fly. The feringnshesr takes action and recovers.
Whatever the story is about, Natasha believes that she has achieved her intention in writing the story. Her handwriting is acceptably legible and many of the words are clearly identifiable.
Obviously, Natasha is on her way to becoming literate, she can follow lines, form letters, spell many words correctly and use the closed conventions of literary narrative. It is worth noting, too, that whatever the feringnshesr is, it is always spelt the same way. Natasha knows that words do not change their spelling. She applies this rule equally consistently to meds and dods.
Given the positively literate features of Natasha's work, it seems reasonable that she has applied consistent spelling rules to the words which are misspelt. Initial conferencing, in this situation, can take the form of suggesting to Natasha that her story is very interesting and asking her to read it so that it will sound the way she wants it to.
The result of the conference is profound. The story, as read, appears below.
There once was a fairy. Her name was Sarah. She lived in a little house.
One day the fairy was sick and she couldn't fly. She got sick and sick and sick and sick and sick.
She called the doctor. He got the medicine. The doctor went out the door. The fairy took the medicine and drank it. She felt better.
FERI is phonically accurate but it doesn't look like a word. Words don't often end in I. But they do end in ING. Still, FERING does not look correct either - poor visual memory can be a big barrier to correct spelling. Wish I could remember what it looked like. I can see the fairy with her wand but ... Try other endings. Add an S, lots of words finish in S. No? What about SH? Maybe ES? How about R. No, its hopeless. But most of those are possibles so leave them there - you never know. Anyway, it doesn't matter that much, I know what I mean even if they don't.
Natasha's Fairy story displays the value of a phonic approach to spelling but it amplifies the problems associated with any single method approach. When either the operator or the method is inadequate to the task, there is no other word attack skill well enough developed to substitute. The dependence of the phonic approach on received sound, on accurate listening and correct transcription of the sound is highlighted in Natasha's story. Her inability to recall the sounds involved in the words HOUSE, DOCTOR and MEDICINE result in her minimal approximations HAST, DODS and MEDS.
Following the initial conference reading of Natasha's story, her teacher pencilled in the correct spelling of the words and spoke about the need to use punctuation/pause marks to make the story easier for other people to read. Natasha accepted the necessary modifications in good spirit and rewrote her story with a lovely picture to illustrate her sick fairy in bed. The issue of whether the teacher should intervene to correct spelling, punctuation and grammar errors in beginning writers' stories had been avoided for another day.
There was a fairy on a hill. She was sad because she did not have friends.
One day she met a girl and she said hello to the girl. The girl said hello to the fairy and asked her if she had a home.
The fairy told the girl that she did not have a home. Then the girl told the fairy she would take her home. The girl gave her some milk and bread with jam. She was happy and went to bed.


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text:
Dimona (hebrejsky דִּימוֹנָה, v oficiálním přepisu do angličtiny Dimona) je město v Izraeli v Jižním distriktu.

Geografie

Nachází se v nadmořské výšce 550 metrů v kopcovité krajině Negevské pouště, 36 kilometrů jihovýchodně od Beerševy a 35 kilometrů západně od Mrtvého moře a příkopové propadliny Vádí al-Araba.

Leží v řídce osídlené oblasti, která je etnicky převážně židovská, ovšem zejména severozápadním směrem odtud začínají rozptýlené osady arabských beduínů. Město je na dopravní síť napojeno pomocí dálnice číslo 25, ze které tu odbočuje směrem k jihu, k městu Jerucham, lokální silnice 204.

V 60. let 20. století byla v severojižním směru postavena železnice spojující Beerševu a Dimonu s centrální a severní částí Izraele. Stojí tu železniční stanice Dimona a končí tu železniční trať Beerševa-Dimona. Kolejové těleso ovšem vede dál k jihu a východu a slouží jako průmyslová vlečka.

Dějiny
Jméno obce odkazuje na biblické město Dímóna citované v Knize Jozue 15,22

Současná Dimona bylo jedno z rozvojových měst, která byla vytvořena v 50. letech 20. století z iniciativy prvního izraelského premiéra Davida Ben Guriona. Dimona byla navržena roku 1953 a založena a osídlena roku 1955, především novými židovskými imigranty ze severní Afriky, kteří také stavěli městské domy.

Roku 1958 byla obec povýšena na místní radu (malé město) a status města získala roku 1969. Znak Dimony, přijatý 2. března 1961, se objevil na poštovních známkách vydaných 24. března 1965.

Když později v tomto desetiletí začínal izraelský jaderný program, bylo nedaleko od Dimony postaveno Izraelské atomové centrum Dimona, a to kvůli relativní izolovanosti v poušti a dostupnosti bydlení.

Průmysl
Počátkem 80. let 20. století dominoval v Dimoně textilní průmysl – mezi nejznámější společnosti patří Dimona Textiles Ltd. Od té doby bylo mnoho továren uzavřeno. Tyto továrny nesmí být zaměňovány s Dimonským centrem nebo s Izraelským atomovým centrem Dimona, které jako "textilní továrny" označil David Ben Gurion. Dimuna Silica Industries Ltd. vyrábí křemené a vápenné tmely.

V současnosti je Dimona s populací přes 30 000 obyvatel třetím největším městem v Negevu. Přibližně třetina populace pracuje v průmyslu (chemické továrně blízko Mrtvého moře, hi-tech společnostech a textilních obchodech) a další třetina v oblasti služeb. Vzhledem k zavádění nových technologií, bylo mnoho zaměstnanců nadbytečných a po jejich propuštění se zvýšila míra nezaměstnanosti na 10%.

Demografie
Podle údajů z roku 2009 tvořili naprostou většinu obyvatel Židé – cca 29 400 osob (včetně statistické kategorie "ostatní", která zahrnuje nearabské obyvatele židovského původu ale bez formální příslušnosti k židovskému náboženství, cca 32 200 osob).

Jde o středně velkou obec městského typu s dlouhodobě stagnující populací. K 31. prosinci 2017 zde žilo 33 700 lidí. Navzdory neustálému ubývání populace během 80. let se populace města začala zvětšovat během 90. let po přílivu židovských imigrantů z bývalého SSSR.

Dimona je domovem unikátní černé židovské komunity, takzvaní Black Hebrews, vedení jejím zakladatelem a duchovním vůdcem Ben Ammi Ben-Izraelem. Jde o komunitu židovských konvertitů, kterou nelze zaměňovat s černými Židy etiopského původu (takzvanými Falaši). Populace Black Hebrews v Dimoně čítá zhruba 2 000 obyvatel s dalšími rodinami v Aradu, Micpe Ramon a v oblasti Tiberiasu. Jejich oficiální postavení v Izraeli bylo problémem po mnoho let, ale v květnu 1990, byl problém vyřešen vízy typu B/1 a o rok později dočasným občanstvím. Status byl prodloužen do srpna 2003, kdy jim izraelský ministr vnitra udělil trvalé občanství.

* údaje za rok 2001 a od roku 2010 zaokrouhleny na stovky

Slavní rodáci
 Josi Benajun (1980), fotbalista

Partnerská města
  Andernach, Porýní-Falc, Německo (1975)

Odkazy

Reference

Související články
 Izraelské atomové centrum Dimona
 Mordechaj Vanunu
 Dimonský radar

Externí odkazy

 Oficiální internetové stránky

Města v Izraeli
Jižní distrikt (Izrael)
Izraelský jaderný program

redpajama_set_name: RedPajamaWikipedia


Inspirational Quotes And Thoughts On Ways You Can Help Other People.
There are a number of ways we can help other people. Helping other people has a ripple of effect of adding light and love to our world.
Various people took to Twitter and shared quotes and their thoughts on how each of us can help other people so we can all make this world a much better and sunnier place.
Jesus is way, truth, life. #HowYouCouldHelpIn5Words ??
#HowYouCouldHelpIn5Words Go all in every day.
#HowYouCouldHelpIn5Words it's free to be nice.
#HowYouCouldHelpIn5Words Be more supportive, not judgmental !
Teach a person to swim.
Offer rides to the store.
Understand not everyone can help.
Ask if someone needs help.
Pray when all else fails.
Give food vouchers, not money.
Don't force or rush. Gentle.


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Osmansko medvladje ali osmanska državljanska vojna (turško Fetret Devri, obdobje medvladja) je bila državljanska vojna v Osmanskem cesarstvu, v kateri so se po porazu Bajazida I. v bitki pri Ankari 2. julija 1402 za oblast v cesarstvu spopadli njegovi sinovi. Vojna je trajala od 20. julija 1402 do  5. julija 1413.

Timur Lenk je po zmagi pri Ankari za sultana potrdil Mehmeda Čelebija. Mehmedovi bratje Isa Čelebi, Musa Čelebi, Sulejman Čelebi in kasneje še Mustafa Čelebi se z njegovo odločitvijo niso strinjali in vsak zase zahtevali osmanski prestol. Posledica je bila državljanska vojna, ki se je končala z bitko pri Çamurluju 5. julija 1413. Zmagovalec je bil Mehmed Čelebi, ki se je po zmagi razglasil za sultana Mehmeda I. in ponovno združil Osmansko cesarstvo.

Državljanska vojna

Isa in Mehmed
Vojna med sinovi Bajazida I. je izbruhnila leta 1403. Najstarejši sin Sulejman je iz Odrina (Edirne) vladal v malo pred tem osvojeni Bolgariji, celi Trakiji, Makedoniji in severni Grčiji. Drugi sin, Isa Čelebi, se je razglasil za neodvisnega vladarja v Bursi, Mehmed pa je ustanovil svoje kraljestvo v Amasyi. Vojna je izbruhnila med Mehmedom in Iso. Sledili sta bitki pri Ermeni-beliju in Ulubadu (marec-maj 1403), po katerih je Isa pobegnil v Konstantinopel, Mehmed pa je zasedel Burso. Po bitki med Mehmedom in Iso pri Karasiju je poraženi Isa pobegnil v Karaman. Iso so kasneje v kopališču umorili Mehmedovi agenti.

V vojno se vmeša Sulejman

Drugega preživelega Bajazidovega sina, Muso Čelebija, ki je bil ujet v bitki pri Ankari, je Timur na Mehmedovo prošnjo izpustil iz pripora pri Jakubu Germijanu. Po Isovi smrti je Sulejman z veliko vojsko prišel iz Rumelije v Anatolijo. Pohod je bil uspešen. Marca 1404 je osvojil Burso  in malo kasneje še Ankaro.

V Anatoliji je nastal predah, ki je trajal od leta 1405–1410. Mehmed je leta 1410 poslal Muso z majhno vojsko čez Črno morje  Trakijo, da bi napadel Sulejmanova ozemlja v jugovzhodni Evropi. Sulejman se je zaradi napada kmalu vrnil iz Anatolije v Trakijo, kjer se je med brazoma vnela kratka, vendar krvava vojna. Sulejman je imel sprva prednost in leta 1410 zmagal v bitki pri Kosmidionu, naslednje leto pa je bila njegova vojska pri Odrinu poražena. Sulejman je bil na Musov ukaz usmrčen. Musa je postal vladar osmanskih posesti v Trakiji.

Mehmed in Musa
Bizantinski cesar Manuel II. Paleolog je bil Sulejmanov zaveznik, zato je Musa začel oblegati Konstantinopel. Manuel je na pomoč poklical Mehmeda, tako da so njegovi vojaki branili Konstantinopel pred Musovimi Osmani iz Trakije. Mehmed je izvedel več neuspelih izpadov proti oblegovalcem, potem pa se je moral vrniti v Anatolijo, da bi zatrl upor na svojem ozemlju. Mehmed se je po zatrtju upora vrnil v Trakijo, kjer se mu je pridružil srbski despot Stefan Lazarević.

Vojski rivalskih bratov sta se srečali na ravnini pri Čamurliju (zdaj Samokov, zahodna Bolgarija). Hasan, aga Mehmedovih janičarjev, je stopil pred nasprotnikovo vojsko in jo pozval. naj prestopi na Mehmedovo stran. Musa ga je napadel in ubil in bil pri tem tudi sam ranjen. Musova vojska se je hrabro borila, vendar je bila poražena. Musa je pobegnil z bojišča. Kasneje so ga ujeli in zadavili. Po njegovi smrti je ostal Mehmed edini živi sin sultana Bajazida I., ki je zavladal kot sultan Mehmed I. in ponovno združil Osmansko cesarstvo.

Medvladje je bilo izjemen primer bratomorne vojne, ki bi lahko postala običajna pri osmanskih nasledstvih.

Politični naslovi
V medvladju je edino Mehmed Čelebi koval denar, na katerem se je naslavljal sultan. Sulejman je koval denar z napisom Emir Sulejman b. Bajazid, na Musovih kovancih pa je bil napis Musa b. Bajazid. Isovi kovanci se niso ohranili.

Sklici

Viri

 Finkel, Caroline (2006). Osman's Dream: The Story of the Ottoman Empire 1300–1923. London: John Murray. ISBN 978-0-7195-6112-2.
 Imber, Colin. The Ottoman Empire. London: Palgrave/Macmillan, 2002. ISBN 0-333-61387-2.
 Kastritsis, Dimitris J. The Sons of Bayezid: Empire Building and Representation in the Ottoman. Civil War of 1402-1413. Brill, 2007. ISBN 978-90-04-15836-8.

Osmansko cesarstvo


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Mass covid testing of students starts on Monday ahead of Christmas trips home
They'll be offered two tests over three days to ensure they don't take the coronavirus back to their families.
Cheryl McEvoyContent Editor
Thousands will be tested across the country (Image: PA)
Mass testing of students for coronavirus in Scotland will start next week.
Thousands are expected to take part in the huge programme, designed to help ensure it's safe for them to return home for Christmas.
Updated guidance has been published by the Scottish Government advising students to take extra precautions to minimise the risk of infection.
Scotland covid lockdown review RECAP as Glasgow remains in level 4 restrictions
Scotland's Christmas coronavirus bubble rules and how they will work
The voluntary testing programme will begin on Monday and can be accessed via their university.
Further education Minister Richard Lochhead said the priority is to keep students and their families safe.
He explained: "This is part of a huge UK-wide effort by colleges and universities to test asymptomatic students before they leave their term-time accommodation.
"I want to thank all students for their tremendous resilience and patience this academic year and I know that they will continue to do all they can to stay safe and ensure a happy reunion with their loved ones."
The move has been welcomed by the National Union of Students.
President Matt Crilly added: "We now have our part to play and so I'd strongly encourage any student moving household over the holidays to plan ahead and get tested if you can."
Tests should be taken twice over three days and are available free to students without symptoms planning to return home for Christmas. Results will be available within half an hour.
Scotland's convener of universities, Professor Gerry McCormac pointed out: "A double negative result will give you more confidence to travel home but it doesn't change the need to practise personal safety measures, wear a face covering, avoid crowds, keep two metres distance and wash your hands regularly to minimise your risk."


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OUT OF MIND » THE INSANITY OF REALITY » GOVERNMENT & THE NEW WORLD ORDER » POLITICAL CLOWN SHOW ~ Hillary Clinton political critic murdered in Honduras – plus MORE
POLITICAL CLOWN SHOW ~ Hillary Clinton political critic murdered in Honduras – plus MORE
1 POLITICAL CLOWN SHOW ~ Hillary Clinton political critic murdered in Honduras – plus MORE on Tue Apr 26, 2016 9:56 am
Hillary Clinton political critic murdered in Honduras – She called out Clinton by name
Posted on April 26, 2016 by lozzafun
A "nightmare regime"
When she was Secretary of State, Hilary Clinton green-lighted a violent right wing coup against the democratically elected president of Honduras.
She then worked to tirelessly to discredit its critics.
Now one of those critics, a woman who was a leading human rights leader, just got a bullet in the head.
She wasn't shy about mentioning Hilary Clinton by name.
Now, during the presidential primary and election season, she won't be saying anything. – See more at: http://www.brasschecktv.com/videos/assassination-studies-1/hillary-clinton-political-critic-murdered-in-honduras.html#sthash.eyDb2Ejm.dpuf
Thanks to: https://lozzafun1.wordpress.com
2 Re: POLITICAL CLOWN SHOW ~ Hillary Clinton political critic murdered in Honduras – plus MORE on Tue Apr 26, 2016 9:58 am
Trump and Hillary Refuse to Explain Why They Both Share the Same Address in Delaware
Posted by Claire Bernish
Claire Bernish | ANTIMEDIA
Wilmington, DE — As it turns out, Hillary Clinton and Donald Trump share something pertinent in common, after all — a tax haven cozily nested inside the United States.
This brick-and-mortar, nondescript two-story building in Wilmington, Delaware would be awfully crowded if its registered occupants — 285,000 companies — actually resided there. What's come to be known as the "Delaware loophole" — the unassuming building at 1209 North Orange Street — has become, as the Guardian described, "famous for helping tens of thousands of companies avoid hundreds of millions of dollars in tax."
Reportedly dozens of Fortune 500 companies — Coca-Cola, Walmart, American Airlines, and Apple, to name a few — use Delaware's strict corporate secrecy laws and legal tax loopholes by registering the North Orange Street address for official business.
"Big corporations, small-time businesses, rogues, scoundrels, and worse — all have turned up at the Delaware address in hopes of minimizing taxes, skirting regulations, plying friendly courts or, when needed, covering their tracks," theNew York Times' Leslie Wayne described in 2012. "It's easy to set up shell companies here, no questions asked."
While the legitimacy of taxes as a concept may be up to personal interpretation, what matters in Clinton's use of the so-called Delaware loophole, in particular, is her constant harping on the need for corporations and elite individuals to pay their fair share. In other words, Clinton's employment of North Orange Street amounts to a telling, Do As I Say, Not As I Do. And, as the Guardian notes, both of "the leading candidates for president – Hillary Clinton and Donald Trump – have companies registered at 1209 North Orange, and have refused to explain why."
As Rupert Neate explained for the Guardian, being registered in the tiny state allows "companies to legally shift earnings from other states to Delaware, where they are not taxed on non-physical incomes generated outside of state."
In fact, some have claimed — all revelations of Panamanian documents aside — the use of tax-friendly locations inside the U.S. makes it the biggest tax haven in the world, with Delaware, alone, costing other states some $9 billion in lost taxes over the past decade. Clinton has repeatedly touted the needs for tax transparency and to shut down foreign havens with similar loopholes.
"Some of you may have just heard about these disclosures about outrageous tax havens and loopholes and superrich people across the world are exploiting in Panama and elsewhere," Clinton told the Pennsylvania AFL-CIO annual Constitutional Convention earlier this month. "We are going after all these scams and make sure everyone pays their fair share here in America."
Oh, the irony.
According to Neate, a Clinton spokesman explained, "ZFS [Holdings, LLC] was set up when Secretary Clinton left the State Department as an entity to manage her book and speaking income. No federal, state, or local taxes were saved by the Clintons as a result of this structure."
Why, if what the spokesman claims to be true, would Clinton bother using an address in Delaware?
Of the 515 companies Trump officially registered with the Federal Election Commission, "We have 378 entities registered in the state of Delaware," the billionaire told the Guardian, "meaning I pay you a lot of money, folks. I don't feel guilty at all, OK?"
Delaware's incredibly business-friendly structure that allows for such a crowded address is completely legal, though the ability to create shell corporations lends to shady dealings and is "a magnet … which individuals and corporations can use to evade an inestimable amount in federal and foreign taxes," as a report by the Institute on Taxation and Foreign Policy has described.
Still, Clinton's constant moralizing on tax transparency — and her spokesperson's claims she hasn't benefited from the North Orange Street address — proves, yet again, her stances offer little in the way of a solid foundation.
Don't forget to follow the D.C. Clothesline on Facebook and Twitter. PLEASE help spread the word by sharing our articles on your favorite social networks.
Thanks to: http://www.dcclothesline.com
3 Re: POLITICAL CLOWN SHOW ~ Hillary Clinton political critic murdered in Honduras – plus MORE on Tue Apr 26, 2016 10:00 am


Air Malta, Malta's National Airline, is planning to open up a new route to Oran, Algeria's second largest city. The twice weekly frequency is expected to operate every Monday and Thursday from 20th July till 31st August.
This service will compliment the twice weekly flights to Algiers that will increase to three weekly flights during the peak summer months just after Ramadan. Flights to Algiers this summer will operate every Monday, Thursday and Sunday.
Air Malta's flights to both Algiers and Oran will offer much needed connectivity between the two countries and mainland Europe through Malta.
Oran is the commercial, industrial, and educational centre of western Algeria. It is a major port city on the northwestern Mediterranean coast, located 432 kilometres (268 miles) from the capital Algiers. The city has a metropolitan population area of approximately 1,500,000, making it the second largest city in Algeria.
Air Malta held a Press Conference today announcing its second route in Algeria. (From left Mr Reda Benyounes from Soleil Voyages, Air Malta's General Sales Agents, Mr Anthony Dalli, Air Malta's Area Manager - North Africa, and Mr Robert Falzon, Malta's Consul General in Algeria).


The HP LaserJet Pro P1606dn changes the HP LaserJet P1505 Printer ($ 199.99) in HP's line, yet with a variety of significant renovations. In particular, it's much quicker and includes both a duplexer and also a network adapter as standard. At 9.7 by 15.2 by 11.2 inches (HWD) and also only 15.4 pounds, the LaserJet Pro P1606dn is both smaller sized as well as lighter compared to the majority of inkjets. However, it's big sufficient to hold a 250-sheet paper tray along with the built-in duplexer.
Between the individual desktop laser printer and also the freestanding workgroup maker sits a group which might best be called SOHO (tiny office, home office) lasers. These are much faster than the entry-level devices, usually around the 20ppm mark, as well as typically have paired print built-in as standard. HP's new HP LaserJet Pro P1606dn Printer sits in this group, with an efficiency appropriate to bet a case in the small business market, also.
The HP LaserJet Pro P1606dn Printer is sensibly swift when printing text, but it was slower than numerous printers to spool graphical print work. Including this spool time, it provided our mixed graphics test at just under 19ppm. The black message was crisp as well as dark, however, it seemed as though the printer had boosted the comparison of pictures, making them look artificial. The good news is, this had not been as evident in images as well as PowerPoint slides.
At HP LaserJet Pro P1606dn 15.4 extra pounds, the cuboidal black instance feels solid, as well as the plastic snap-on paper trays are quite sturdy. Nonetheless, the sliding paper holder in the front tray is wobbly as well as flimsy. Due to the fact that the paper tray is partly outside and extends from the front, a clumsy associate can bump as well as damage it, as well as a ham-handed paper changer, can easily snap it off. The printer's small size, though, and also unassuming black body will certainly blend in nicely with any type of office atmosphere.
Follow the instructions on how to install printer HP LaserJet Pro P1606dn with Setup files.
Install software for HP LaserJet Pro P1606dn.
Related Posts of "HP LaserJet Pro P1606dn Printer Software Download & Setup for Mac and Windows"


Your feedback about Windows Management Framework 5.0 is valuable to us; we invite you to provide feedback at all times. For important information about changes in behavior from Windows PowerShell 5.0, and a list of known issues with this release, be sure to read the WMF 5.0 release notes. You can log bugs and suggestions by using the PowerShell forum within the Windows Server UserVoice.
Please see release notes for the list of products that are compatible and incompatible with Windows Management Framework 5.0.
WMF 5.0 requires Microsoft .NET Framework 4.5 or above. You can install Microsoft .NET Framework 4.5 or above by following the instructions at Installing the .NET Framework.
Please see release notes for installation instructions.


Before beginning the journey in becoming a psychotherapist, I earned a Masters in Public Health on the Community Track from Touro University in Vallejo, CA. The research project I focused on, the correlation of literacy and health literacy for previously incarcerated clients, informed my practice of the influence society and one's environment can have on a person's physical and emotional well-being. As a graduate student, I began developing a larger and richer world view which I carried over to my next step.
I earned my Master of Science in Social Work from Columbia University in New York City specializing in Advanced Clinical Practice. During this time, I interned at a legal firm advocating for tenant rights in all 5 boroughs and at a public elementary school in East New York providing individual, group and family therapy.
I returned to the San Francisco Bay Area upon graduation and focused on my work with children, teenagers and their families in both the school setting and outpatient clinical setting in San Jose, Palo Alto and Oakland for 3 years. I then worked with adult clients at an outpatient clinic in the Bayview Hunters Point neighborhood of San Francisco. After 2 years there, I transitioned to working for Lyon-Martin Health Services in 2014 where I served as an Integrated Behavioral Health Specialist and Mental Health Therapist.
I am excited to return working with children and teens while continuing with adults in a different setting!
- trauma (EMDR Basic Trained).


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Creative Placemaking
Creative Placemaking Toolbox
Home ›› About ›› About Artscape ›› Artscape: 30 Years of Creative Placemaking
About Artscape
Artscape: 30 Years of Creative Placemaking
Our Programs and Services
Clients and Events
Artscape has grown from a small group of individuals concerned about the space-related challenges of artists to an international leader in the field of creative placemaking and city-building through the arts. For 30 years, Artscape has been making space for creativity and transforming communities.
Artscape grows out of the Toronto Arts Council at a time when the real estate market is booming. City inspectors are closing down illegal artist live/work spaces located in warehouse buildings, and there is growing concern about the viability of artists and arts organizations continuing to live and work in downtown Toronto.
In association with the Toronto Arts Council, Artscape publishes No Vacancy, the first comprehensive review of space issues and concerns of Toronto's arts community. This work is instrumental in achieving recognition and funding from the City of Toronto as its partner in addressing the space-related challenges of the arts.
Just after the bottom falls out of the real estate market in the early 90s, Artscape jumps into the real estate development business. Artscape's first project at 96 Spadina Avenue provides affordable work studios in Toronto's then-burgeoning gallery district.
Artscape continues to build its capacity as a studio provider with the opening of 45 work spaces at Artscape Liberty Village in the heart of Liberty Village at 60 Atlantic Avenue. This largely abandoned industrial area quickly becomes a hot spot for artists, designers, filmmakers and new media enterprises.
A home for new music is created with the 1993 opening of The Music Gallery. This Artscape development has since been demolished to make way for a condominium development.
Artscape Non-Profit Homes Inc. (ANPHI) is set up to build affordable artist housing.
Artscape opens the first legal artist live/work building, Artscape West Queen West, at 900 Queen Street West in Toronto. This prized Queen West location provides subsidized and market rate housing for 22 artists and their families, as well as six artist work studios.
The opening of the Parkdale Arts and Cultural Centre at 1313 Queen Street West marks Artscape's first foray into mixed-use development in a project that combines low-cost artist live/work studios with business associations, social service organizations and a gallery.
Artscape Gibraltar Point opens, offering a range of space, programs and services for the arts, not-for-profit, government and education sectors in a unique and tranquil setting on the Toronto Islands.
Artscape introduces the Gibraltar Point International Artist Residency Program into its program portfolio, furthering the professional development of artists both in Canada and internationally.
Artscape publishes the first edition of Square Feet: The Artist's Guide to Renting and Buying Work Space.
Artscape plays a catalytic role in the revitalization of The Distillery Historic District with the opening of Artscape Distillery Studios, comprising 60 work and retail studios, offices, rehearsal and performance spaces.
The City of Toronto grants approval in principle to the Artscape Wychwood Barns at the site of the former Wychwood Car Barns site.
Building on the success of previous conferences hosted by Artscape, Creative Places + Spaces brings together policy-makers and practitioners whose work will shape cities and creative communities of the future.
Queen West Art Crawl launches.
Artscape begins to share its knowledge with cities and communities across Canada and internationally, including New York City, Manchester, Kingston, Ottawa, Vancouver, Edmonton, Hamilton and Sudbury.
Creative Places + Spaces2 takes place in Toronto featuring more than 70 experts and hosting more than 600 international delegates.
Artscape Foundation launches to support Artscape's charitable work.
Artscape breaks ground on the Artscape Wychwood Barns, an arts and environmental centre run by and for the community at the site of the former Wychwood TTC streetcar repair facility.
An innovative partnership is forged in the Queen West Triangle between Artscape, the City of Toronto, Westside Gallery Lofts (Urbancorp) and Active 18 that will see the creation of a 56,000-square-foot artist live/work project, Artscape Triangle Lofts, within the Westside Lofts development at 150 Sudbury Street.
Artscape Wychwood Barns opens – a $22 million retrofit of five derelict TTC repair barns into a community hub with affordable housing and a cultural centre.
Artscape Triangle Lofts is under construction and registration for sales of the below-market ownership units begins.
Artscape publishes the findings of the Creative Convergence Project, a collaboration with TIFF, CFC, Evergreen, OCADU and MaRS, in "Convergence Centres: Building Capacity for Collaboration." The study reveals new ways that talent, space and collaboration are being combined and leveraged to fuel our capacity for innovation.
Creative Places + Spaces: The Collaborative City takes place in Toronto in October 2009. The third major conference presented by Artscape engages global perspectives on collaboration and connects them with local change-makers. Click here to view a series of brief films featuring key messages from the conference.
In December 2009, Artscape, Toronto Community Housing Corporation and The Daniels Corporation announce a collaborative working partnership with the local community on the development and operation of a vibrant new arts and cultural centre in Regent Park. Through federal and provincial sources, $24 million in capital funding is pledged under the Infrastructure Stimulus Fund.
In January 2010, Artscape announces it has come to an understanding with the Toronto Lands Corporation, as agent for the Toronto District School Board, to purchase the century-old inner city Shaw Street School and repurpose it as Artscape Youngplace, a 75,000-square-foot centre for arts and community programming with a focus on youth.
Artscape launches its new Mentorship and Coaching Program to provide support to organizations and communities hoping to develop multi-tenanted centres. Artscape Creative Placemaking and Creative Spacemaking workshops have now reached more than 800 participating organizations and individuals from more than 100 communities across Canada.
November 2010 Artscape celebrates the opening of the Artscape Triangle Lofts providing 48 below market live/work condos and 20 affordable rental live/work units for artists along with a rental gallery in the heart of West Queen West.
Construction on Regent Park Arts and Cultural Centre begins.
Construction on Regent Park Arts and Cultural Centre and Artscape YOUNGplace is under way.
Artscape publishes "Advancing Toronto's Centre for Creative Sector Entrepreneurship: Research and Sector Engagement Findings" and moves forward pre-project development on its proposed new Centre for Creative Sector Entrepreneurship – Artscape Launchpad.
Artscape publishes a completely revised, updated edition of "Square Feet," now entitled "Square Feet: An Artist's Guide to Renting or Buying Creative Space."
Artscape completes a study for the City of Toronto exploring the potential to develop a new model of creative and cultural hubs in Toronto's priority neighbourhoods.
Click here to read in depth case studies on Artscape's properties.
Click here to find out more about Creative Placemaking.
Click here to access tools and resources to support Creative Placemaking in your community.
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Artscape Distillery Studios
Artscape Wychwood Barns
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When we are sick, most of us appreciate a kind word and a caring touch. When our health concerns are serious and we are forced to rely on the competence of others, we all want a trained professional at our bedside. Certified nursing assistants (CNAs) are there at every stage of our life, providing precisely that level of expertise.
CNA's are often the first to greet us when we arrive at the doctor's office, hospital or nursing home. CNA's are specially trained to evaluate their patient's condition using a series of assessment tools. The "vital signs" include measurements of the body temperature, heart rate, respiratory rate and blood pressure. So named the "vital" signs because readings fall within a predictable range when we are well, they are often the first clue that something isn't right with our health. CNA's are trained to measure vital signs, to test blood sugar and blood oxygen levels, and to recognize abnormal symptoms. They know when a reading or symptom needs to be reported to the nurse in charge. CNA's are trained to detect when and how to perform CPR (cardio-pulmonary resuscitation), to provide range of motion exercises, to monitor and protect the skin, and to safely transfer and assist patients. CNA's are also trained to collect lab specimens and to prepare patients for surgeries and diagnostic tests. After passing a proficiency exam, a CNA has the tools required to become a valuable member of the healthcare team, contributing to early prevention, detection and treatment of sickness and disease. They are the "eyes and ears" and often the "first responders" in the healthcare arena.
While having competent caretakers is important, we also want to know that the person taking care of us is concerned for our wellbeing. The CNA is the person who answers your call light when you need assistance or have a question. The CNA helps you safely walk when you are weak and wipes your forehead when you feel sick. The CNA patiently feeds patients when they are temporarily or permanently unable to do so, and bathes them when they are at their most vulnerable. CNA's are a dedicated, hard working and invaluable part of the medical team. Performing in the fast paced, high pressure world of today's healthcare world isn't easy. To do so with a smile and a kind word takes the devotion certified nursing assistants are committed to.
How much do Certified Nursing Assistant's Make?


Richard Feinberg is a professor of international political economy at the School. He has enjoyed a distinguished career as diplomat, policy advisor, corporate consultant, university professor and author of over 200 books and articles on international relations. His four decades of engagement with United States foreign policy spans government services — in the White House, Department of State and Department of the Treasury — numerous Washington-based public policy institutes, the Peace Corps in Chile and, now, academia.
Feinberg is an authority on U.S. foreign policy, multilateral institutions (IMF, World Bank, NAFTA) and summitry (APEC, Summitry in the Americas, G-8). He is an expert on trade and investment, globalization, democratization and non-governmental organizations.
Feinberg is a non-resident senior fellow at the Brookings Institution authoring three reports assessing Cuba's economic reforms on foreign investment, the country's private enterprise and the emergence of its middle class.
Some major accomplishments include publishing "The Triumph of Allende" at age 24; joining the Carter administration to focus U.S. foreign policy toward the promotion of human rights and democratic freedoms; publishing "The Intemperate Zone: The Third World and the Challenge to U.S. Foreign Policy"; serving as the principal architect of the 1994 Miami Summit of the Americas for the Clinton Administration; and serving as book reviewer for the Western Hemisphere section of Foreign Affairs since 2005.
"Reaching Out: Cuba's New Economy and the International Response"