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What's really going on here? Never did trust those electronic voting machines!
"Voters casting their ballots early in Texas claimed this week that when casting Democratic or Republican straight-ticket ballots, voting machines in at least 80 counties in the Lone Star State flipped their votes to the other party in key midterm races, including the high-profile competition between incumbent Sen. Ted Cruz and his Democratic opponent Beto O'Rourke.
The Texas secretary of state's office on Friday said that there have been issues reported with Hart eSlate voting machines, which are used in approximately 30 percent of counties statewide. The machines feature a wheel for selecting candidates and buttons to move from screen to screen.
But the secretary of state's office said the issues were not caused by the voting machines, but by voters themselves.
"The Hart eSlate machines are not malfunctioning, the problems being reported are a result of user error — usually voters hitting a button or using the selection wheel before the screen is finished rendering," said Sam Taylor, spokesman for the office of Secretary of State Rolando Pablos.
The Houston Chronicle reported that Democratic voters claimed the machines indicated that they were about to cast a vote for Cruz, when they originally intended to choose O'Rourke. Several people said they were able to get help from employees at polling places in order to change their vote back.
Mickey Blake, a Houston resident, told KTRK-TV that she voted for Democrats down the ticket but saw before she submitted it that O'Rourke's name was not selected.
The machines are used in around 80 counties in the state. Early voting in Texas began Monday and has featured a strong turnout.
The machine's manufacturer, Hart InterVCivic, attributed the issues to 16-year-old technology and defended the machines' accuracy.
The Texas Democratic Party called the issue "a malfunction," saying it was causing Democrats to inadvertently vote for Cruz and accused the secretary of state's office of not doing enough to warn voters of potential issues.


One of your first tasks now will be to obtain a uniform and the proper tools and equipment for your new adventure.
Now that you have received your badge, you are ready to work games. In order to do that, you must work with an Assignor.


THIS GUARANTY is made as of November 23, 1999, by 3Dfx INTERACTIVE, INC.
Agreement described below (in such capacity "Agent").
part, being herein collectively called the "Note").
"Agent" means the Person who, at the time in question, is the "Agent"
time are "Lenders" under the Credit Agreement.
(a) and (b) of Section 2.
heretofore or hereafter delivered in connection herewith or therewith.
or obligors, primary or secondary, of any or all of the Obligations.
other claims are subordinated to the Obligations.
instrument evidencing any such indebtedness or liability.
of a bankruptcy, reorganization, or similar proceeding involving Borrower.
pursuant to any of the Obligation Documents.
by Agent, which Agent may incur as a result of such failure.
considered a primary and liquidated liability of Guarantor.
other indulgences with respect thereto.
indemnifications, affirmative or negative covenants, or otherwise).
owing, under any one or more of the Obligation Documents.
to perfect Agent's or Lenders' rights in any or all Security.
(vi) Discharge, release, substitute or add Obligors.
such monies upon any particular Obligations.
in any way, or afford Guarantor any recourse against Agent or any Lender.
the Obligations or any other obligations to Agent or any Lender.
impracticability, or other defense or excuse whatsoever.
any Obligor, Agent or any Lender.
Obligations or is otherwise primarily liable therefor.
the actual payment and performance by Guarantor under this Guaranty.
without bringing a separate action against any other Obligor.
thereupon revert to and be vested in Agent and Lenders.
agreement or instrument relating thereto or relating to any Obligation.
under Section 34.02 of the Texas Business and Commerce Code.
following Section 5 or otherwise), and all other notices of any kind whatsoever.
others may be destroyed or diminished by exercise of any such right or remedy.
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make any statements contained therein not misleading.
shall be enforced to the fullest extent permitted by applicable law.
hereof. The words "this Guaranty," "this instrument," "herein," "hereof,"
acceptance hereof and in reliance hereon.
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AFFECT THE RIGHT OF AGENT TO SERVE PROCESS IN ANY OTHER MANNER PERMITTED BY LAW.


The Hardy-Weinberg Principle is taught to help give an understanding of gene frequency in a population.
It is a useful tool when used accurately. Unfortunately, there is a bit of "bait-and-switch" happening with the term "evolution". People start out using evolution correctly, and then equivocate with molecules-to-man evolution. This takes a helpful principle and turns it into an inaccurate propaganda device.
Public schools, colleges, and universities today teach the Hardy-Weinberg Principle in biological science courses, and many of them do so inaccurately. The inaccuracy of these teachings are simply due to either a misunderstanding of the application of the Hardy-Weinberg Principle and equation, or it may be due to a deliberate misinterpretation of its uses to further support and promote a "macroevolutionary" philosophy. We will discuss how instructors are using the Hardy-Weinberg Principle as evidence for molecules-to-man Darwinian evolution, why this method of application is incorrect, and what the Hardy-Weinberg Principle can be used for. We will also answer the fundamental question: does the Hardy-Weinberg Principle itself require any rejection of biblical foundations?
Follow the link to continue reading "The Hardy-Weinberg Equilibrium Model: Evidence for Evolution?"
Dog with a Super Sniffer?
Is Theistic Evolution a Happy Medium?


I am feeling proud after the 1st Windhoek grading of 2016.
Well done all involved in the preparation and execution of the grading.
More than 140 students graded in 9 1/2 hours.
Hard work once again proofed and awarded.


text:
An Overview of Karyotyping
More in Brain & Nervous System
More Neurological Diseases
Neurological Symptoms & Diagnosis
Karyotype's Role in Diagnosis and Prenatal and Predictive Screening
Kathleen Fergus
Kathleen Fergus, MS, LCGC, is a board-certified genetic counselor who has worked extensively with families affected by Down syndrome.
Shaheen Lakhan, MD, PhD
Medically reviewed by Shaheen Lakhan, MD, PhD
Shaheen Lakhan, MD, PhD, is an award-winning, board-certified physician-scientist and clinical development specialist.
Genetics Basics
What a Karyotype Can Show
How They're Performed
A karyotype is, quite literally, a photograph of the chromosomes that exist within a cell. A healthcare provider may order a karyotype during pregnancy to screen for common congenital defects. It is also sometimes used to help confirm a leukemia diagnosis. Less commonly, a karyotype is used to screen parents before they conceive if they are at risk of passing a genetic disorder to their baby. Depending on the aim of the testing, the procedure may involve a blood test, bone marrow aspiration, or such common prenatal procedures like amniocentesis or chorionic villus sampling.
DEPT. OF CLINICAL CYTOGENETICS, ADDENBROOKES HOSPITAL / Science Photo Library / Getty Images
Chromosomes are the thread-like structures in the nucleus of cells that we inherit from our parents and that carry our genetic information in the form of genes. Genes direct the synthesis of proteins in our bodies, which determines how we look and function.
All humans typically have 46 chromosomes, 23 of which we inherit from our mothers and fathers, respectively. The first 22 pairs are called autosomes, which determine our unique biological and physiological features. The 23rd pair is composed of sex chromosomes (known as X or Y), which designate whether we are female or male.
Any error in genetic coding may affect development and the way our bodies work. In some cases, it can place us at an increased risk of a disease or a physical or intellectual defect. A karyotype allows healthcare providers to detect these errors.
Chromosomal defects occur when a cell divides during fetal development. Any division occurring in the reproductive organs is called meiosis. Any division occurring outside of the reproductive organs is called mitosis.
A karyotype characterizes chromosomes based on their size, shape, and number to identify both numerical and structural defects. While numerical abnormalities are those in which you either have too few or too many chromosomes, structural abnormalities can encompass a wide range of chromosomal flaws, including:
Deletions, in which a portion of a chromosome is missing
Translocations, in which a chromosome is not where it should be
Inversions, in which a portion of a chromosome flipped in the opposite direction
Duplications, in which part of a chromosome is accidentally copied
Numerical Abnormalities
Some people are born with either an extra or missing chromosome. If there are more than two chromosomes where there should only be two, this is called a trisomy. If there is a missing or damaged chromosome, that is a monosomy.
Among some of the numerical abnormalities a karyotype can detect are:
Down syndrome (trisomy 21), in which an extra chromosome 21 causes distinctive facial features and intellectual disabilities.
Edward syndrome (trisomy 18), in which the extra chromosome 18 translates to a high risk of death before the first birthday.
Patau syndrome (trisomy 13), in which an extra chromosome 18 increases the likelihood of heart problem, intellectual disability, and death before the first year.
Turner syndrome (monosomy X), in which a missing or damaged X chromosome in girls translates to a shorter height, intellectual disability, and an increased risk of heart problems.
Klinefelter syndrome (XXY syndrome), in which an extra X chromosome in boys can cause infertility, learning disabilities, and underdeveloped genitalia.
Structural Abnormalities
Structural abnormalities are not as commonly seen or identified as trisomies or monosomies, but they can be every bit as serious. Examples include;
Charcot-Marie-Tooth disease, caused by a duplication of chromosome 17, leading to reduced muscle size, muscle weakness, and motor and balance difficulties.
Chromosome 9 inversion, associated with intellectual disability, facial and skull malformation, infertility, and recurrent pregnancy loss.
Cri-du-Chat syndrome, in which the deletion of chromosome 5 causes delayed development, small head size, learning impairment, and distinctive facial features.
Philadelphia chromosome, caused by the reciprocal translocation of chromosomes 9 and 22, resulting in a high risk of chronic myeloid leukemia.
Williams syndrome, in which the translocation of chromosome 7 causes intellectual disability, heart problems, distinctive facial features, and outgoing, engaging personalities.
The expression of structural chromosomal abnormalities is vast. For example, about 3% of Down syndrome cases are caused by a translocation on chromosome 21. However, not all chromosomal abnormalities confer to illness. Some, in fact, may be beneficial.
One such example is sickle cell disease (SCD) caused by a defect on chromosome 11. While inheriting two of these chromosomes will lead to SCD, having just one can protect you against malaria. Other defects are believed to provide protection against HIV, stimulating the production of broadly neutralizing HIV antibodies (BnAbs) in a rare subset of infected people.
When used for prenatal screening, karyotypes are typically performed during the first trimester and again in the second trimester. The standard panel tests for 19 different congenital diseases, including Down syndrome and cystic fibrosis.
Karyotypes are sometimes used for preconception screening under specific conditions, namely:
For couples with a shared ancestral history of a genetic disease
When one partner has a genetic disease
When one partner is known to have an autosomal recessive mutation (one that can only cause disease if both partners contribute the same mutation)
Karyotyping is not used for routine preconception screening but rather for couples whose risk is considered high. Examples include Ashkanzi Jewish couples who are at high risk of Tay-Sachs disease or African American couples with a family history of sickle cell disease.
Couples who are either unable to conceive or experience recurrent miscarriage may also undergo parental karyotyping if all other causes have been explored and excluded.
Finally, a karyotype may be used to confirm chronic myeloid leukemia in association with other tests. (The presence of the Philadelphia chromosome on its own cannot confirm the cancer diagnosis.)
A karyotype can theoretically be performed on any body fluid or tissue, but, in clinical practice, samples are obtained in four ways:
Amniocentesis involves in the insertion of a needle into the abdomen to obtain a small amount of amniotic fluid from the womb; it is performed with the guidance of an ultrasound to avoid harm to the fetus. The procedure is performed between weeks 15 and 20 of pregnancy. While relatively safe, amniocentesis is associated with a one-in-200 risk of miscarriage.
Chorionic villus sampling (CVS) also uses an abdominal needle to extract a sample of cells from placental tissues. Typically performed between weeks 10 and 13 of pregnancy, CVS carries a one-in-100 risk of miscarriage.
Phlebotomy is the medical term for a blood draw. The blood sample is usually obtained from a vein in your arm, which is then exposed to ammonia chloride to isolate leukocytes (white blood cells) for karyotyping. Injection site pain, swelling, and infection are possible.
Bone marrow aspiration may be used to aid in the diagnosis of chronic myeloid leukemia. It is typically performed by inserting a needle into the center of the hip bone and is done under local anesthesia in a healthcare provider's office. Pain, bleeding, and infection are among the possible side effects.
Sample Evaluation
After the sample is collected, it is analyzed in a lab by a specialist known as a cytogeneticist. The process begins by growing the collected cells in a nutrient-enriched media. Doing so helps pinpoint the stage of mitosis in which the chromosomes are most distinguishable.
The cells are then placed on a slide, stained with a fluorescent dye, and positioned under the lens of an electron microscope. The cytogeneticist then takes microphotographs of the chromosomes and re-arranges the images like a jigsaw puzzle to correctly match the 22 pairs of autosomal chromosomes and two pairs of sex chromosomes.
Once the images are correctly positioned, they are evaluated to determine whether any chromosomes are missing or added. The staining can also help reveal structural abnormalities, either because the banding patterns on the chromosomes are mismatched or missing, or because the length of a chromosomal "arm" is longer or shorter than another.
Any abnormality will be listed on a karyotype report by the chromosome involved and the characteristics of the abnormality. These findings will be accompanied by "possible," "likely," or "definitive" interpretations. Some conditions can be definitively diagnosed with a karyotype; others cannot.
Results from a prenatal karyotype take between 10 and 14 days. Others are usually ready within three to seven days. While your healthcare provider will usually review the results with you, a genetic counselor may be on-hand to help you better understand what the results mean and do not mean. This is especially important if a congenital disorder is detected or preconception screening reveals an increased risk of an inheritable disease if you have a baby.
American College of Obstetricians and Gynecologists. Prenatal Genetic Diagnostic Tests.
Leukemia & Lymphoma Society. Blood and Bone Marrow Tests.
National Human Genome Research Institute. Chromosome Abnormalities Fact Sheet.
Centers for Disease Control and Prevention. Facts about Down Syndrome.
Thompson PA, Kantarjian HM, Cortes JE. Diagnosis and Treatment of Chronic Myeloid Leukemia in 2015. Mayo Clin Proc. 2015;90(10):1440–1454. doi:10.1016/j.mayocp.2015.08.010
The Purpose and Steps Involved in a Karyotype Test
How Down Syndrome Is Diagnosed
9 Rare Genetic Trisomies Beyond Down Syndrome
What Is a Zygote?
Are You at Risk of Having a Child With Down Syndrome?
Is Acute Myeloid Leukemia Hereditary?
Learn About the NIPT for Prenatal Screening
Myeloid Leukemia: Key Differences Between Acute and Chronic Cases
Genetic Testing With Whole Exome Sequencing
Understanding the Basics of of Genes, DNA, and Chromosomes
How Do Doctors Diagnose and Stage Leukemia?
Why People With Cat Eye Syndrome Have a Very Distinctive Look
The Role of the Philadelphia Chromosome in Identifying Cancer
Acute Myeloid Leukemia Survival Rates and Outlook
Why Are Chromosome Translocations Important in Blood Cancers?
How Chronic Myeloid Leukemia and Chronic Lymphocytic Leukemia Differ

redpajama_set_name: RedPajamaCommonCrawl


I've felt guilty for abandoning this space for a long time now.
I had the best intentions of keeping up with posts and sharing my journey through pastry school in France. But, along the way, writing about the life I was living became time consuming and started to feel like a chore that was taking time away from having actual experiences. I felt as though I didn't have the energy to devote to Sweetest Crumb, and if I couldn't do the blog right then I shouldn't do it at all. Without making a real decision, I abandoned it.
I did finish pastry school at Ferrandi. It was one of the most fulfilling and unforgettable experiences of my life. I cannot stress how waking up every morning and getting to do something you love for 8 hours makes you feel. I relished every moment of school, tried to take away as much as I could, asked nonstop questions and was entirely aware of how lucky I was every single day. People always say to "live in the moment" and this was the one time in my life when I knew I had succeeded in that.
After school, I completed two internships in Paris. The first was one of the most challenging and downright traumatic experiences of my life. Nevertheless, it taught me so much about myself and I learned to stand up for myself, saying "no" when something just isn't right for me. The second was an amazing professional experience which I now look back at fondly.
At the end of my first year in Paris, we decided that our hearts had grown too attached to the city to leave just yet – plus I wanted more professional experience under my belt (apron). We applied for a second round of visas and extended our stay for another year. The majority of this year I worked as a commis in a well-known pastry shop in Paris. I felt so lucky to have the job but was flung out of my comfort zone and challenged constantly. I had to work in a language and culture which was still quite foreign to me, often feeling like the outsider. I had to come to terms with being a beginner in a field where almost everyone else was significantly younger, faster and better than me (French pastry chefs usually start their careers at age 14-16 so by their mid 20′s they often have a decade of experience). I worked for minimum wage but for the first time in my life was earning a paycheque doing something I loved. This time strengthened me as a person and as a professional and I wish I could live it all again.
As our second visas were coming to an end, we decided that it was the right time to return to Canada. I cannot explain how difficult it was to leave Paris. The city became my home. This was my first adult home, the first place where I truly felt like I was living a life I chose and answering to no one but myself. It was strangely thrilling to live in a bubble away from family and friends: people who had known me for years and developed expectations of who I was and what I would or should do. It was equally thrilling to not have to live up to anyone's expectations, judgements or deal with seemingly harmless questions like: "why did you leave your financially awesome (but otherwise crappy) career in accounting? (are you crazy?)" "what are you even going to do with pastry after?" "when are you getting married?" "why haven't you bought a house yet? Or a car? Or had a baby?" etc. etc… Instead, I got to know myself really well. I learned the value of being happy and learned what I need in my life to feel fulfilled. I can now say "no" to something which just doesn't serve me with no hesitation. I don't feel the need to follow the same path as everyone else, and I thank Paris for that.
Living in Paris, I also got swept up by the energy of the city. The beauty of the city is inspiring and unforgettable – art and culture are just thrown in your face at every turn. It makes you feel like life is meant to be enjoyed and anything is possible. While I've been back in Edmonton as of January, a piece of my heart is still, and forever will be, in Paris. Leaving was heartbreaking. I never knew I could fall in love with a city like this and saying goodbye tore me up like an intense breakup. Even now, months later, emotions feel raw – it is painful to look through photos, think about the sunset rooftop view from our apartment or sitting with other Parisians, feeling the Friday night energy along Canal St Martin. As sad as goodbyes are, I know that me and Paris are meant to be and I will be back – à bientôt, ma chérie.


text:
namespace PocketSharp
{
  public class PocketLimitException : PocketException
  {
  }
}

redpajama_set_name: RedPajamaGithub


The Parts Department at Mike Maroone Auto maintains a comprehensive inventory of high quality genuine OEM (Original Equipment Manufacturer) parts. Our highly knowledgeable staff is here to answer your parts inquiries. Should we not carry a part for which you're searching, we can always order it for you and receive it within a timely manner.


Open Longevity is a project that initiates, organizes, and guarantees openness of clinical trials of antiaging therapies.
Two important components of our project are an online expert system, which interprets users' biomedical information in terms of aging biology, and new infrastructure for antiaging clinical trials. They are closely connected: the data obtained through trials is taken into account in the operations of the expert system, and the funds raised from users are spent on antiaging research.
At the first stage, the aim of which is the development of the platform and launching of the first trials, we will raise funds through our ICO. Our task is to build a self-sufficient system that will provide paid services to individuals but at the same time solve important problems for humanity on a noncommercial basis.
We do not plan to protect our therapies with patents—our research results will be publicly available. We endeavor to direct patients' energy toward the fight against aging, and in our experience, our policy of openness attracts projects, funding, scientists, and volunteers to us.
One of the common concerns in the industry is that, once on the market, antiaging medicine will become available only to the elite. The openness of our project is a possible solution to this potential problem.
Moreover, publishing final and intermediate results, as well as research protocols and all related materials, will give us the highest level of expertise.
All clinical trials will be carried out in strict accordance with existing norms. We will prepare questionnaires, informed-consent forms, permissions of ethical committees, and brochures describing the design of our experiments. We will involve a CRO (contract research organization), laboratories, and clinical institutions that traditionally carry out similar research.
We will include patients in a global movement to seek and test potential antiaging therapies that, once proven effective, will immediately become part of their own lives.
✅ COMMENTS: ICO "Open Longevity"


West Room, empty of books, circa 1936.
When is a case too old to cite?
I always know my adversary has run out of creative arguments when they throw in one of the weakest attacks: that a case I cited is too old.
This happened to me recently as I was writing an appeal in the Second Department (which is an intermediate appeal level court in New York). In my opening brief I cited a case from the 1970s to support a legal doctrine–establishing fraud through a material omission–that is pretty well-settled but not discussed in detail so frequently. I liked the case because the facts were similar and it was from the Court of Appeals–the highest level of precedence in New York.
My opponent tried (albeit badly) to distinguish the case, but he put most emphasis on the fact that it was 40 years old. It was obviously a weak attack. But it got me to thinking...when is a case too old to cite in support of my argument?
I did a little research on this question and there is no clear answer.
My favorite legal writing guru–Bryan Garner–says when you are dealing with a governing court (i.e., the court whose decisions are binding on the court to whom you are arguing) the more recent the citation the better. Unless you are citing to a decision written by a well-respected judge on a famous issue, then an old case is rarely the most persuasive one that you could use.
That sounds like good advice to me, and I always look for the most recent case for whatever doctrine I am asserting. But sometimes my research returns a bunch of cases from the 1800s, and I immediately feel uncomfortable.
In general, I don't like to use cases written before the 1900s. They are so hard to read with their meandering style and language that is so flowery it often feels like bad prose. And I have to spend too much time searching for the point; when I do find it I have to translate it into modern speak before I can talk about it in my brief. What can I say? I'm a 21st century lawyer, so I like my legal reasoning clear, concise, and crisp.
I'm also pretty sure that no one–and by no one I mean judges, their law clerks, and even my adversaries–is going to bother reading a pre-1900 case anyway. Who has time for that? For many well-settled doctrines, judges know the law off the top of their head and a citation from the 1850s is nothing more than an unnecessary point that I was able to find a case stating the doctrine. It takes more skill than that to win an argument.
So what do I do when all I can find are dusty opinions from the last two centuries?
If the case is really old (i.e., pre-1900), I check my research again–is it possible that a doctrine of law I am dealing with in 2015 has not been dealt with since 1855? Not likely.
If I still find only old cases, I will check a treatise or other respected secondary source. If those sources cite the old case as the seminal decision for a doctrine, I will consider using it.
Before I use it, though, I will think about whether I can state the doctrine without citing a case at all. For example, judges (and adversaries) already know that summary judgment is warranted where there is no question of fact to be decided by the trier of fact. So there is no need to cite a case stating it.
If I conclude a citation is necessary, then I will research whether the old case I am eyeing has been superseded by a statute. NOTE: be careful with this one! Many cases appear to be good law until you read them carefully. The older the case, the more problematic this is. For example, any case dealing with bankruptcy that is older than 1978 has to be analyzed in light of the intervening bankruptcy acts. The proliferation of statutes since the 1970s makes this true for many other doctrines as well. And Lexis/Westlaw indicators don't always take those statutes into account when they make their colored flag labels for a case.
Finally, I will look to see if the doctrine in the old case has been dealt with extensively in the lower level courts. If it has, then I might be satisfied that the old case is worth citing as the seminal case in the higher level court, along with a discussion of the lower level court cases that have applied it.
You'll notice I didn't say I would certainly use the case. After all, the final decision of when to cite an old case comes down to my intuition–and my creative flair in the art of argument. You will have to make that decision on your own too–it's part of cultivating good lawyerly judgment.
I would also love to hear from you: what do you think about when deciding if a case is too old to cite?
Tell me your tips and tricks in the comment section, so we can all benefit from them.
Or if you'd rather out source your research needs to me at On Point Expertise, then click the button below to fill out an inquiry and I will get started.
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Disclaimer: the content on this site is intended as general information for attorneys, law firms, and non-lawyers seeking appellate representation; nothing stated on this site or on the blawg should be taken or used as legal, accounting, or other professional advice; rather, it is information on how lawyers can use services from Zara Watkins, Esq. on a freelance, outsource, or outsourcing basis and how non-lawyers can engage Zara Watkins, Esq. to represent them on appeal. None of the content contained on this site constitutes grounds to establish an attorney-client relationship, and you should not consider it as such. Updates in the law may or may not be discussed; please do not rely on any information contained on this site or the blawg as currently applicable. There is no guarantee that you will win your appeal.
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Copyright 2019. All rights reserved. Zara Watkins, Esq., PO Box 627, NY, NY 10274 (mailing address; home office address available upon request). TEL: Nine One Seven - Six Eight Nine - Three One Eight Zero.


text:
package com.github.mdr.mash.input

import scala.language.implicitConversions
import com.github.mdr.mash.input.InputSequence.KeyPress
import com.github.mdr.mash.input.Key.BasicKey

sealed trait InputSequence

object KeyDsl {

  implicit def charToBasicKey(c: Char): BasicKey = BasicKey(c)

  implicit def basicKeyToKeyPress(key: Key): KeyPress = KeyPress(key)

  def control(c: Char) = KeyPress(c, control = true)

  def control(key: Key) = KeyPress(key, control = true)

  def alt(c: Char) = KeyPress(c, alt = true)

  def alt(key: Key) = KeyPress(key, alt = true)

  def altShift(c: Char) = KeyPress(c, alt = true, shift = true)

  def altShift(key: Key) = KeyPress(key, alt = true, shift = true)

  def shift(key: Key) = KeyPress(key, shift = true)

  implicit class RichChar(c: Char) {
    def control = KeyPress(c, control = true)
  }

}

object InputSequence {

  import KeyDsl._

  val ControlD = control('d')

  case class KeyPress(key: Key, shift: Boolean = false, control: Boolean = false, alt: Boolean = false) extends InputSequence

  case class EscapeSequence(s: String) extends InputSequence

  case class OtherSequence(s: String) extends InputSequence

  case object TerminalWindowChanged extends InputSequence

}


text:
Q: Jboss 7 deploy struts war file When i try to deploy war file in jboss 7 AS server i got following error
23:23:07,111 ERROR [org.jboss.msc.service.fail] (MSC service thread 1-7) MSC00001: Failed to start service jboss.deployment.unit."testapp.war".POST_MODULE: org.jboss.msc.service.StartException in service jboss.deployment.unit."testapp.war".POST_MODULE: Failed to process phase POST_MODULE of deployment "testapp.war"
    at org.jboss.as.server.deployment.DeploymentUnitPhaseService.start(DeploymentUnitPhaseService.java:119) [jboss-as-server-7.1.1.Final.jar:7.1.1.Final]
    at org.jboss.msc.service.ServiceControllerImpl$StartTask.startService(ServiceControllerImpl.java:1811) [jboss-msc-1.0.2.GA.jar:1.0.2.GA]
    at org.jboss.msc.service.ServiceControllerImpl$StartTask.run(ServiceControllerImpl.java:1746) [jboss-msc-1.0.2.GA.jar:1.0.2.GA]
    at java.util.concurrent.ThreadPoolExecutor.runWorker(ThreadPoolExecutor.java:1145) [rt.jar:1.7.0_95]
    at java.util.concurrent.ThreadPoolExecutor$Worker.run(ThreadPoolExecutor.java:615) [rt.jar:1.7.0_95]
    at java.lang.Thread.run(Thread.java:745) [rt.jar:1.7.0_95]
Caused by: java.lang.RuntimeException: Error getting reflective information for class fr.improve.struts.taglib.layout.LabelledTag with ClassLoader ModuleClassLoader for Module "deployment.testapp.war:main" from Service Module Loader
    at org.jboss.as.server.deployment.reflect.DeploymentReflectionIndex.getClassIndex(DeploymentReflectionIndex.java:70) [jboss-as-server-7.1.1.Final.jar:7.1.1.Final]
    at org.jboss.as.ee.metadata.MethodAnnotationAggregator.runtimeAnnotationInformation(MethodAnnotationAggregator.java:58)
    at org.jboss.as.ee.component.deployers.InterceptorAnnotationProcessor.handleAnnotations(InterceptorAnnotationProcessor.java:85)
    at org.jboss.as.ee.component.deployers.InterceptorAnnotationProcessor.processComponentConfig(InterceptorAnnotationProcessor.java:70)
    at org.jboss.as.ee.component.deployers.InterceptorAnnotationProcessor.deploy(InterceptorAnnotationProcessor.java:55)
    at org.jboss.as.server.deployment.DeploymentUnitPhaseService.start(DeploymentUnitPhaseService.java:113) [jboss-as-server-7.1.1.Final.jar:7.1.1.Final]
    ... 5 more
Caused by: java.lang.NoClassDefFoundError: Lorg/apache/struts/util/MessageResources;
    at java.lang.Class.getDeclaredFields0(Native Method) [rt.jar:1.7.0_95]
    at java.lang.Class.privateGetDeclaredFields(Class.java:2509) [rt.jar:1.7.0_95]
    at java.lang.Class.getDeclaredFields(Class.java:1819) [rt.jar:1.7.0_95]
    at org.jboss.as.server.deployment.reflect.ClassReflectionIndex.<init>(ClassReflectionIndex.java:57) [jboss-as-server-7.1.1.Final.jar:7.1.1.Final]
    at org.jboss.as.server.deployment.reflect.DeploymentReflectionIndex.getClassIndex(DeploymentReflectionIndex.java:66) [jboss-as-server-7.1.1.Final.jar:7.1.1.Final]
    ... 10 more
Caused by: java.lang.ClassNotFoundException: org.apache.struts.util.MessageResources from [Module "deployment.testapp.war:main" from Service Module Loader]
    at org.jboss.modules.ModuleClassLoader.findClass(ModuleClassLoader.java:190) [jboss-modules.jar:1.1.1.GA]
    at org.jboss.modules.ConcurrentClassLoader.performLoadClassUnchecked(ConcurrentClassLoader.java:468) [jboss-modules.jar:1.1.1.GA]
    at org.jboss.modules.ConcurrentClassLoader.performLoadClassChecked(ConcurrentClassLoader.java:456) [jboss-modules.jar:1.1.1.GA]
    at org.jboss.modules.ConcurrentClassLoader.performLoadClass(ConcurrentClassLoader.java:398) [jboss-modules.jar:1.1.1.GA]
    at org.jboss.modules.ConcurrentClassLoader.loadClass(ConcurrentClassLoader.java:120) [jboss-modules.jar:1.1.1.GA]
    ... 15 more

23:23:07,118 INFO  [org.jboss.as.server] (HttpManagementService-threads - 7) JBAS015870: Deploy of deployment "testapp.war" was rolled back with failure message {"JBAS014671: Failed services" => {"jboss.deployment.unit.\"testapp.war\".POST_MODULE" => "org.jboss.msc.service.StartException in service jboss.deployment.unit.\"testapp.war\".POST_MODULE: Failed to process phase POST_MODULE of deployment \"testapp.war\""}}
23:23:07,206 INFO  [org.jboss.as.server.deployment] (MSC service thread 1-3) JBAS015877: Stopped deployment testapp.war in 87ms
23:23:07,206 INFO  [org.jboss.as.controller] (HttpManagementService-threads - 7) JBAS014774: Service status report
JBAS014777:   Services which failed to start:      service jboss.deployment.unit."testapp.war".POST_MODULE: org.jboss.msc.service.StartException in service jboss.deployment.unit."testapp.war".POST_MODULE: Failed to process phase POST_MODULE of deployment "testapp.war"

A: This problem happens when you try to deploy an ear/war/jar deployment in jboss7/wildfly and you have not specified what dependencies need your application.
Jboss7/Wildfly has his own module class loader to isolate applications and dependencies running into the same java virtual machine.
All deployments in jboss/wildfly are loaded as modules (not only the content included in modules folder, the content of deployments folder are modules too).
If you don't have packaged "struts" jar into the application deployment file, you will need to deploy the required dependencies as modules and tell to jboss that your application depends on it.
So, you have at least five alternatives:

*

*Build your application as an Uber-Jar including your dependencies
inside.

*Deploy your application and dependencies in the deployments folder and add a manifest entry in your application to tell to jboss that
your application depends on it.

*Deploy your application and application dependencies (jars) in the deployments folder and add a jboss deployment descriptor xml in your
application to tell to jboss that your application depends on it.

*Deploy your application in the deployments folder and create modules for your dependencies (if do not exist) and add a manifest
entry in your application to tell to jboss that your application
depends on it.

*Deploy your application in deployments folder and create modules for your dependencies (if do not exist) and use a jboss deployment
descriptor xml in your application to tell to jboss that your
application depends on it.

For more information visit:
jboss 7 classloader
jboss 7 deployment descriptors

redpajama_set_name: RedPajamaStackExchange


text:
http_request 'explicit_action' do
  action :options
end

http_request 'with_attributes' do
  url    'http://my.url'
  action :options
end

http_request 'specifying the identity attribute' do
  url    'identity_attribute'
  action :options
end


Want a Italian Restaurant & Pizza in Hua Hin?
Hua Hin is the closest beach resort of Bangkok, located just 281 kms away. This makes it an ideal weekend getaway for locals and tourists visiting Bangkok.
Getting to Hua Hin from Bangkok is easy. All options for transport are available in this route – bus, minibus, car, train and airplane. Hua Hin is barely 3 hours drive from Bangkok, with many places of tourist interest along the way like Koh Wang. This virtually rules out the flight option. Moreover, SGA Airlines, the only airlines flying in the route has cancelled the flights indefinitely. Chartered flights are still available.
Hourly bus services are available from Southern Bus Terminal (Sai Tai Mai Bus Terminal, Pinklao) in Bangkok from 0400 hrs to 2220 hrs. Air-conditioned and non-air-conditioned buses ply the route from Southern Bus Terminal to Srasong Road in Hua Hin. Prior reservation is required to secure seats in buses. The tickets have to be booked at the bus station in person. The ticket costs about 160 THB.
Some of these buses will take you further south like the adjoining district of Pranburi and Petchburi. However, passengers to Hua Hin get down at the Clock Tower located at the heart of town. The buses take slightly more time to reach the destination as they stop many times on the way. The journey duration is three to three and a half hours.
Minibuses are much faster than buses. They cover the distance is about two and a half hours. They have a limited seating capacity of 11-12 seats. In Bangkok, minibuses start from Ratchawitee Hospital near the Victory Monument.
Minibuses ply the route every 15 minutes from 0600 hrs to 1900 hrs. The ticket costs 200 THB. In Hua Hin, the minibuses unload passengers in a site off Petchkasem Road in the centre of town.
You can either flag down a cab or approach a travel agency either directly or through your hotel, to hire a cab. However, decide on the fare before the trip, as it can vary vastly according to your negotiating skills. It usually is in the range of 1000 to 3000 THB.
You may hire a car and drive all the way to Hua Hin. There are two routes from Bangkok to Hua Hin. The shorter one is along Thonburi-Paktho Road, via Samut Songkhram, Petchkasem Highway and along the route to Prachuab Khirikhan. The longer one is via Nakhon Pathom, Ratchaburi and Petchaburi.
Train is a safer and comfortable way to reach Hua Hin from Bangkok. Trains run from Hua Lum Pong Railway Station in Bangkok to the historic Hua Hin railway station. Both stations can be reached easily.
Train tickets can be reserved 60 days in advance either in person at any railway station of Thailand or online. Online reservations cost 200 THB extra, which is levied at the railway station, where you go to collect the tickets. The journey time is 3½ to 4 hours.


Nestack are experts when it comes to building apps which will remain quick, efficient, and reliable for various different types of businesses.
AngularJS is far more flexible than basic HTML so you can build single-page applications and make development and testing stages more simple.
Nestack Technologies is your preferred option for AngularJS development. We are a specialist in Small-Team Software Development by following Tailored Agile Methods.
AngularJS offers a powerful and result-focused framework to assist with the creation of quick real-time solutions and data-streaming apps.
AngularJS is a widely used open source framework by Google which is robust, highly scalable and often used in the creation of user-focused apps. AngularJS helps to develop dynamic, interactive, data-driven and structured cross platform mobile and web application. Angular is a hugely useful framework for MVC architecture on the client side and features like 2 way data binding, Templates, Dependency Injection and Reusable Component/Directives are the special features that makes angular different from other frameworks.
The Nestack offshore development center offers reliable AngularJS and Angular 4 development services which provides end-to-end product development. The outsource developers at Nestack will keep you in the loop at every stage of development too. Nestack always offer comprehensive plans to give you a good understanding of what the development team is doing, who is doing it, and why it's being done.
Nestack AngularJS Maintenance includes 24/7 tech support. You never know when you may need to call on the experts.


text:
Rio-Carb appoints Wesco Engineering as its Namibian agent | Rio-Carb,
Sias Suurd from Wesco Engineering has been tasked with overseeing Rio-Carb's growing presence in the Namibian region.
Rio-Carb, a leading manufacturer of R-C700 CrC wear liners and pipes for heavy materials-handling applications in the mining and allied resources industries, has announced that Wesco Engineering has been appointed as its official agent in Namibia.
Sias Suurd from Wesco Engineering has been tasked with overseeing Rio-Carb's growing presence in the Namibian region. At Wesco based in Walvis Bay, he has overall responsibility for strategic growth and development, identifying new business opportunities, and determining marketing and business development strategies.
Suurd's extensive experience in Namibia includes a stint as Support Equipment Engineering Manager at Husab's Swakop Uranium Mine, near Swakopmund in the Erongo region in western-central Namibia, one of the largest uranium mines in the world.
Suurd's responsibilities at Swakop Uranium included developing and managing the support equipment maintenance strategic plan, developing and managing the medium- and short-term support equipment maintenance objectives, and identifying, implementing, and applying best-practice maintenance strategies, standards, systems, and monitoring mechanisms in support of equipment production planning.
Suurd has also worked at BHP Billiton's Wolvekrans and Klipspruit collieries, cutting his teeth at the mining giant as a Junior Engineer. He holds a Bachelor of Mechanical Engineering, Honours in Design Engineering, and a Master's in Business Administration, all from the University of Pretoria.
Rio-Carb's foray into the highly competitive Namibian market follows a particularly noteworthy 2016, in the course of which the company was awarded ISO 9001 certification, launched new products, and improved its internal and manufacturing processes. In 2017, it plans to add additional state-of-the-art equipment to its fully-automated welding facilities in Alberton, Johannesburg.
Tags:NamibiaRio-CarbSwakop UraniumWesco Engineering
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text:
Discovering the Best Cure for Snoring!
by Rosalie Toledo October 5, 2018
Snoring is a problem which is affecting millions and the Schnarchmuseum's unusual collection traces humankind's millennia's long struggle to cure this issue.
But do we yet know the formulae for curing this issue?
Considering the medieval fact of a steel cannonball which lays on a shelf above the head of a mannequin whose mouth is covered with a thick leather muzzle-like mask.
Believe it or not, these medieval torture devices were actually used to prevent snoring.
Sleep researcher and therapist Josef Wirth found the mask and cannonball some 17 years ago and they are now a part of Schnarchmuseum in Alfred, Germany.
These items were collected through the patients who brought them to him. They stated usually that the item has not worked on them.
He stored all the items collected and grew the collection. He was always on the lookout for new items.
The museum is now visited by 1,500 people from around the world each year. Soldiers who snored had it sewn into their uniforms to stop them from sleeping on their backs. Wirth explains that the cannonball was used during the War of Independence in the US.
It is of no help if they snore through their nose as the 100-year-old mask next to it is designed to keep a snorer's mouth shut while they are asleep.
How Snoring is related to Sleep Apnea?
Snoring is a phenomenon created by the obstructed airflow during breathing which causes parts of the respiratory system to vibrate.When you consider just how many people are affected by snoring, It is not surprising how much interest there is in Wirth's project.
When your throat muscles and tongue intermittently relaxes and blocks the airway during sleep, it can also be a sign of obstructive sleep apnea.
Scientists have still not found a simple solution or the issue which affects hundreds of millions of people despite the fact that snoring has persisted for millennia.
About 41.5% of the population snores while in the US recent data puts the figure at 44% of men and 28% of women is what the British Snoring and Sleep Apnea Association estimates.
Marianne Davey, director of BSSAA states that there will never be a "one solution fits all" cure as there are so many reasons why somebody may snore.
We have to tailor treatment to each individual as your snoring will not have the same cause as the next person.
In order to attain success in managing the snoring issue, the patient will have to work with the treatment.
Changing Lifestyle habits that Help Cure Snoring
Losing weight,eating healthy and avoiding alcohol which is thought to narrow the airways, the main treatment for snoring involves lifestyle changes.
While surgery is an option for those with a deviated septum for example, decongestants and allergy medication can help. Oral devices can also be successful, but care should be taken in choosing as some will cause harm in the long term.
Changing your sleeping position can help to cure acute snoring because different sleep positions have their pros and cons that you should not ignore.
In the ancient times, ideas about how to cure snoring were not all that different. Dionysus, the Greek god of wine was a well-documented perpetrator as the Greeks and Romans knew that over-eating and drinking meant that you were more likely to snore.
Using thyme to reduce snoring was recommended by the Ebers Papyrus of herbal knowledge dating to circa 1550 BC. They are still available today when it comes to snoring oils which are made from thyme and other herbs.
Devices have gone from cumbersome to sleek in modern history and technological advancements.
Rafael Pelayo, the clinical professor at the Stanford Center for Sleep Science and Medicine stated that over time treatments for snoring have evolved and changed but the principals are the same.
Know About the Snoring Devices Available
One such device is an oral appliance which holds the tongue forward while the snorer sleeps. Since 1953 a comparable oral device made from metal rather than the more comfortable plastic which is now used has been around.
They are now normally made using a mold formed to each patient's teeth and mouth shape as the devices have benefited from the technology. 25 years old is the oldest example in the Wirth's museum.
He stated that they are very effective and in the recent times it got much more comfortable and people can change and it is not fixed like the older ones.
Surgery for snoring has also improved. It used to be that they would crush the bone out but now they use radio waves to do it and it heals much faster. Also allergy medication has got much better according to Pelayo.
The first surgery for snoring became widely available to the public in the UK in 1999. Snoring specialist Prof Bhik Kotecha says that robotic surgery is increasingly used for sleep apnea.
He stated that this is the most aggressive form of therapy and the robotics allows you to perform surgery more accurately and it can be used in areas which are more difficult to get at.
Another device is the continuous positive airway pressure ventilator or CPAP. This has also evolved since it was invented in 1980 by Colin Sullivan, an Australian physician.
Looking more like an effort to create Frankenstein's monster, the snoring museum has a kit from 1985. It now tips the scales at as little as 400g making them portable and easy to use at home. Wirth explains that in 1985 CPAP kits weighed 35kg.
Recently approved for further testing is a device which stimulates the nerves which coordinate the muscles in the airways, intended primarily for obstructive sleep apnea.
It requires surgical implantation, in a similar way to that required for a pacemaker. As this technology gets better, it could be applied to snoring. The evolution of snoring treatments does not stop here, according to Lawrence Epstein the former president of the American Academy of Sleep Medicine.
Back to Snoring


Start from the Inchnadamph car park at NC251216 and walk north on the A837 until Ardvreck Castle is reached. Alternatively this section on the modern road can be left out and the walk can be started from Ardvreck Castle. Leave the road at NC242237 and follow the track to Achmore Farm.
Pass east of the farm and continue along the track which now ascends the shoulder of Glas Bheinn. The track is obvious but is wet in places. After the highest point the track descends and is crossed at NC239284 by the path to the Eas a' Chual Aluinn waterfall. Ignore this path and keep straight on until the A837 is reached at NC239288. The track now runs along the west side of the modern road before crossing it at NC240292. After a steep descent the A837 is reached again. Follow the A837 until NC236303 where the old track leaves the road and continues to the shore of Loch Glencoul at NC241316.
2. At the north end does the route follow the path which meets the sea at Newton NC 241 316 or is the last section of the old road overlaid by the A837? The First Edition OS Six Inch map supports the first of these possibilities and that is what has been assumed here.
This is the 'Marble Road' or Lairig Unapool. It is recorded that 'For a few years before 1820, marble quarried at Ledbeg was brought down to Unapool on "tracts for the heavy waggons", and exported by a native of Newcastle' (NSAS Assynt V15, 114). It is also mentioned in Tom Strang's booklet Walk Sutherland and in a leaflet Walks around Assynt by the Assynt Footpath Group. The last two publications say that the road was from Ledmore, where there still is a marble quarry, rather than Ledbeg.


text:
Focused Ultrasound Treatment Comparable to Radiation Therapy for Patients with Painful Bone Metastases
Key Points Prof. Alessandro Napoli and his team at Sapienza University of Rome conducted a comparative phase II clinical trial that enrolled 198 participants with painful bone metastases. When compared with external beam radiation therapy (EBRT), focused ultrasound produced a faster and better pain control response that lasted longer than EBRT. An accompanying editorial praised focused ultrasound as a promising new advance in interventional oncology and suggested that future comparative trials follow this study model as a practical approach to adopting innovative new treatments. Focused Ultrasound and External Beam Radiation Therapy for Painful Bone Metastases: A Phase II Clinical Trial Prof. Alessandro Napoli and his team at Sapienza University of Rome conducted a comparative, nonrandomized, phase II clinical trial that enrolled 198 participants with painful bone metastases. The study compared the safety and effectiveness of treating the bone metastases with focused ultrasound or EBRT. Beyond numeric pain rating scales at 1- and 12-months following treatment, the open-label protocol also included assessment of quality-of-life measures and analysis of adverse events. Focused ultrasound had statistically significant higher overall response rates than EBRT at both 1- and 12-months post procedure and statistically significant lower overall adverse event rates. The authors concluded that focused ultrasound was comparable to EBRT for improving pain palliation and quality of life. In an accompanying editorial, "Radiation Therapy Castle Under Siege: Will It Hold or Fold?" Alexis Kelekis, MD, PhD, EBIR, FSIR, FCIRSE, said that focused ultrasound was among several new advances in interventional oncology for providing local energy deposition. He noted some of the current disadvantages of focused ultrasound (e.g., it is a long and tiring single-session treatment that requires anesthesia) but said that the technology's absence of ionizing radiation and better overall results than EBRT for treating bone metastases make it "a promising alternative for the future." After describing that the partial response rate in the study favored EBRT, Dr. Kelekis added, "Perhaps the future lies in combined therapies and hybrid techniques trying to bridge and exploit the advantages of each therapeutic approach." He went on the praise the study design and suggested that the model should be adopted by more researchers to increase the use of innovative and novel therapies that provide real hope to patients. Suzanne LeBlang, MD, the Foundation's Director of Clinical Relationships, has known Dr. Napoli for nearly 16 years. She says, "Dr. Napoli was one of the early pioneers in the field, and this important paper adds to the mounting body of knowledge about the benefits of focused ultrasound. Moving forward, we are hopeful that others will perform seminal research projects and publish findings for other indications because focused ultrasound is a platform technology that has widespread applicability to other diseases." See Radiology > See Dr. Kelekis' Editorial > See Media Coverage of the Study: Medpage Today
Research Awards Update: Nine Preclinical Projects Initiated in the Fourth Quarter of 2022
Key Points The Foundation's Research Awards Program initiated nine preclinical studies from October through December 2022, the fourth quarter of last year. The funded projects address brain, bone, low back pain, and breast cancer applications of focused ultrasound. The Foundation's Research Awards Program initiated nine new preclinical studies from October through December 2022, the fourth quarter of last year. The funded projects address brain, bone, low back pain, and breast cancer applications of focused ultrasound. "All of the preclinical brain projects are linked to an initiative that came out of the May 2021 glioblastoma workshop," said Lauren Powlovich, MD, the Foundation's Associate Chief Medical Officer. "The aim of this group of projects is to identify a method to better quantify the amount of drug delivered to brain tissue after blood-brain barrier opening (BBBO). We are meeting quarterly to discuss progress and new ideas." Each newly initiated project is listed below. Brain Preclinical Probing the Abilities of Contrast-Enhanced MRI to Track Microbubble-Enhanced Focused Ultrasound Nano-Medicine Delivery in the Brain and Brain Tumors led by Costas Arvanitis, PhD, at the Georgia Institute of Technology For this project, researchers will determine how to confirm therapeutic delivery of nanoparticles to the brain during microbubble-enhanced focused ultrasound (MB-FUS) procedures. The goal is to improve the delivery of therapeutic nanoparticles to brain tumors by studying optimal nanoparticle properties and methods to confirm nanoparticle delivery in the brain and brain tumors. Mapping Drug Concentrations After Blood-Brain Barrier Disruption Using MALDI Mass Spectrometry Imaging led by Nathan McDannold, PhD, at Brigham and Women's Hospital For this project, researchers will explore the use of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry to quantify the amount of therapeutic delivered to brain tissue after BBBO, then creating specific calibration curves to compare with the MRI images. The goal is to identify a method to better quantify the amount of drug delivered to the brain tissue following BBBO. PET-Labeling and Testing of Paclitaxel Nanoformulations with Microbubbles and Focused Ultrasound led by Graeme Woodworth, MD, at the University of Maryland School of Medicine For this project, researchers will determine whether PET-labeling of nanoparticle therapeutics could enable quantitative visualization of localized nanoparticle delivery during microbubble-enhanced blood-brain barrier opening with clinical focused ultrasound systems in advanced preclinical models of glioblastoma. Mapping of Antibody and Liposome Permeability into the Brain Following Focused Ultrasound Treatment Through T1/T2w Dynamic Contrast-Enhanced (DCE) Magnetic Resonance Imaging led by Antonios Pouliopoulos, PhD, at King's College Hospital in London For this project, the research team will confirm focused ultrasound–mediated delivery of antibody- and liposome-based therapies by delivering two MR-labelled model drugs across the blood-brain barrier (BBB) and then conducting DCE MRI scans to determine the extent of drug delivery within the tissue. Evaluation of MRI Visualization of Focused Ultrasound–Induced Blood-Brain Barrier (BBB) Opening in White Matter led by Meghan O'Reilly, PhD, at Sunnybrook Health Sciences Centre For this project, researchers will determine how to improve drug delivery to white matter in the brain. Contrast-enhanced MRI is used to assess changes in BBB permeability following focused ultrasound treatment but the contrast enhancement in white matter is lower than in grey matter, so research is needed to be able to use MRI visualization for both applications. MRI Compatible Optical-Driven Focus Ultrasound for Neuromodulation led by Chen Yang, PhD, at Boston University Ultrasound neural modulation is an emerging noninvasive neuromodulation tool. The goal of this project is to develop a compact, MRI-compatible, optically driven focused ultrasound source for ultrasound neural modulation with a broader accessibility than standard focused ultrasound systems. Its application in noninvasive brain modulation and its efficacy in treating epilepsy in a mouse model will be demonstrated. Body Ultrasound-Triggered Gelation to Treat Discogenic Lower Back Pain led by Constantin Coussios, PhD, at the University of Oxford This one-year collaborative study will combine the materials engineering expertise at Imperial College with the biomedical ultrasound expertise at the University of Oxford to optimize material formulations and focused ultrasound exposure parameters with the objective of translating these techniques for percutaneous nucleus pulposus replacement. Doing so would offer a new minimally invasive day case procedure to treat discogenic lower back pain and restore spinal function. Patterning of Mesenchymal Stem Cell Differentiation for Bone Regeneration Using Focused Ultrasound–Mediated Hydrogel Stiffening led by Mario Fabiilli, PhD, at the University of Michigan For this project, researchers will use focused ultrasound to alter the stiffness of a custom acoustic responsive scaffold (ARS) and stimulate bone regeneration. The ARS contains mesenchymal stem cells encapsulated within hydrogels The hydrogel acts as a surrogate for the native extracellular matrix. The studies seek to demonstrate a proof-of-concept for implanting ARS at the site of bone loss. Preclinical High-Intensity Focused Ultrasound (HIFU) Treatment of Breast Adenocarcinoma Using a Noninvasive Toroidal Transducer led by David Melodelima, PhD, at Inserm LabTAU For this project, researchers will determine whether HIFU ablation of breast adenocarcinoma is feasible and effective with a toroidal transducer. The group will use a clinical device that has previously been effective for liver metastases and pancreatic tumors. Learn How to Apply for a Research Award >
Focused Ultrasound for Pediatric Brain Tumors: Clinical Trial Begins in Toronto
Key Points Researchers at Sunnybrook Health Sciences Centre and The Hospital for Sick Children are collaborating on a clinical trial using focused ultrasound in patients with diffuse intrinsic pontine glioma (DIPG). DIPGs are highly aggressive and devastating brain tumors that affect young children. In this trial, physicians are exploring focused ultrasound-induced blood-brain barrier opening to enhance delivery of chemotherapy to the tumor. Researchers at Sunnybrook Health Sciences Centre and The Hospital for Sick Children (SickKids) have begun a collaborative clinical trial using focused ultrasound to open the blood-brain barrier (BBB) and deliver chemotherapy in patients with diffuse intrinsic pontine glioma (DIPG). DIPGs are highly aggressive and devastating brain tumors that affect young children, typically aged 5–9. They affect a region of the brainstem that regulates the body's involuntary activities such as breathing, heart rate, and swallowing. Only 10 percent of children survive past the two-year mark after diagnosis because current therapies are highly ineffective. One reason that brain tumors – including DIPG – are challenging to treat is the BBB. This protective layer of tightly joined cells that lines the blood vessels in the brain prevents harmful substances, such as toxins and infectious agents, from diffusing into the surrounding brain tissue. However, it can also prevent therapeutic agents – like chemotherapy – from getting into the brain. Focused ultrasound has been shown to temporarily disrupt the BBB in a noninvasive, safe, and targeted manner. The ultrasound waves interact with microbubbles in the vessels, causing them to vibrate rapidly and create openings that can enable therapies to pass through. In this trial, researchers are investigating the safety and feasibility of using Insightec's Exablate Neuro device to open the BBB in 10 participants between the ages of 5 and 18. Participants will undergo focused ultrasound therapy in conjunction with chemotherapy during three treatment cycles, about four to six weeks apart. The first patient underwent the initial procedure earlier this month. The trial is being led by Nir Lipsman, MD, PhD, neurosurgeon and director of Sunnybrook's Harquail Centre for Neuromodulation, and James Rutka, MD, PhD, director of the Arthur and Sonia Labatt Brain Tumour Research Centre at SickKids. "DIPG is a devastating pediatric brain tumor which is inoperable due to its location in the brainstem," says Dr. Lipsman. "Focused ultrasound is an innovative and noninvasive approach to more effectively delivering chemotherapy directly to the tumor. Our hope is that this continued research will bring us closer to enhancing treatments to help change the course of the disease." Sunnybrook Health Sciences Centre is a Focused Ultrasound Foundation Center of Excellence, and the Foundation is funding a portion of this clinical trial. For PatientsIf you are interested in learning more about this clinical trial, please contact James Rutka, MD, (416-813-6425, james.rutka@sickkids.ca) or Maheleth Llinas (416-480-6100 ext 2476, maheleth.llinas@sunnybrook.ca). Read Sunnybrook's Announcement >See Coverage by CTV > Additional DIPG Trials in the USFocused ultrasound is being investigated to address DIPG at other sites in the US. At Children's National Hospital (CNH) in Washington, DC, a team of researchers is conducting two clinical trials. One approach is similar to the Sunnybrook trial, where focused ultrasound will be used to open the BBB in an effort to deliver chemotherapy to the tumor. The other trial at CNH is testing sonodynamic therapy as a way to destroy the tumor. Both clinical trials are currently recruiting patients. CNH became the Foundation's first pediatric Center of Excellence in 2020. Another DIPG clinical trial investigating focused ultrasound-induced BBB opening to deliver chemotherapy began in July 2021 at Columbia University.
Meeting Report: American Epilepsy Society (AES) 2022
Published: 5 January 2023
Key Points The 2022 Annual Meeting of the AES was held December 2–6 in Nashville, Tennessee. Harvard neurologist Ellen Bubrick, MD, led a special session on "Focused Ultrasound: A Rapidly Growing, New Approach to Epilepsy Treatment." The workshop described how various mechanisms of action of focused ultrasound can be used in the treatment of many types of epilepsy. The 2022 Annual Meeting of the AES was held December 2–6 in Nashville, Tennessee. As one of the oldest neurological professional organizations in the United States, AES holds the largest worldwide meeting and exhibition for scientific and clinical research on epilepsy and clinical neurophysiology. On Sunday, December 4, Ellen Bubrick, MD, assistant professor of neurology at Harvard Medical School and associate neurologist in the Department of Neurology at Brigham and Women's Hospital, led a special session on focused ultrasound at the meeting. The session was an Investigators Workshop titled "Focused Ultrasound: A Rapidly Growing, New Approach to Epilepsy Treatment." Along with Dr. Bubrick, the expert panel included Raag Airan, MD, PhD (Stanford University), Charles Caskey, PhD (Vanderbilt University), and Vibhor Krishna, MBBS, MS (the University of North Carolina). The workshop described how focused ultrasound can be used for ablative (high intensity) or neuro-modulatory (low intensity) effects in the treatment of many types of epilepsy. It also covered current clinical trials for ablation and neuromodulation in epilepsy and promising preclinical studies that are using focused ultrasound to open the blood-brain barrier (BBB) for targeted drug delivery. More than 7,600 physicians, scientists, advanced practice providers, nurses, psychiatrists, psychologists, engineers, pharmacists, advocates, and other professionals from 70 countries attend the conference to share data and learn about the diagnosis, study, prevention, treatment, and cure of epilepsy. The meeting also offered a virtual attendance option, ES 2022 Digital Select, to provide recordings of approximately 120 hours of selected programming and access to ePosters from December 13, 2022, through March 13, 2023 (90 days). See the Meeting Website >
Meeting Report: 183rd Meeting of Acoustical Society of America (ASA) 2022
Key Points The 183rd meeting of the Acoustical Society of America took place in Nashville, Tennessee, from December 5–9, 2022. All abstracts are searchable on the meeting planning tool or in the PDF of the open access program. The Foundation thanks Kevin J. Haworth, PhD, Schott Schoen, Jr., PhD, Adam Maxwell, PhD, and Eli Vlaisavljevich, PhD, for assistance in writing this meeting report. The 183rd meeting of the Acoustical Society of America (ASA) took place in Nashville, Tennessee, from December 5–9, 2022. Dozens of abstracts were presented in the field of biomedical acoustics (BA) during the meeting, and joint sessions were held with the physical acoustics (PA), computational acoustics (CA), and signal processing acoustics (PA) technical committees. A broad range of topics were covered, and the material extended from fundamental science investigation to translational bench studies, preclinical studies, and in-human investigations in both imaging and therapeutic ultrasound. The sessions relevant to focused ultrasound are listed below. All abstracts are available in a searchable PDF of the open access program or by using the searchable online meeting planning tool. During the open BA Technical Committee meeting on Wednesday evening, several senior researchers, including Larry Crum, Christy Holland, and Mark Schafer, noted that the content of the meeting was excellent in its scope and depth. The range of invited speakers included great talks from both well-established members of the field and early-career speakers (such as Harriet Lea-Banks of Sunnybrook Research Institute and Dongwoon Hyun from Stanford). The early-career speakers introduced some fascinating new topic areas in ultrasound and provided a refreshing influx of new ideas and concepts. It was a reminder of how bright the future is for this research community and an inspiration for further research. The following presentations were particularly notable: 2aBAb6. "Volatile nanodroplets for neurological applications" (Lea-Banks, Sunnybrook Research Institute) discussed delivery of pentobarbital to specific regions of the brain without disruption of the blood-brain barrier and having specific anesthetic effects to those limited regions. 2pBAb3. "Fibrin-targeted phase shift microbubbles outperform fibrin-targeted microbubbles for the treatment of microvascular obstruction" (Pacella, University of Pittsburgh) discussed results from a series of investigations into the use of nanodroplets plus ultrasound to increase perfusion after acute myocardial infarction. Bench, small animal, and large animal model studies were used with an excellent interplay in how each informed the observations of the others. 3aBA1. "Acoustic droplet vaporization for nonthermal ablation of brain tumors" (Porter, University of Texas at Austin) discussed a series of studies performing mechanical ablation in the rat brain and the improved localization and more thorough treatment when nanodroplets were used as contrast nucleation agents. A special session titled "Detection and quantification of bubble activity in therapeutic ultrasound" was held on Thursday. This session opened with Brian Fowlkes from the University of Michigan providing a summary of the outcomes of the Fall 2021 joint AIUM/FUSF workshop on this topic, as well as current efforts through IEC and other bodies to develop standards. This was followed by presentations in specific areas of cavitation detection and characterization by optical imaging, Doppler, MRI, and passive mapping. A brief panel discussion then outlined considerations for standardizing measurements. Panelists generally agreed that measurements should be guided by application. When possible, it may be valuable to use relative measurements rather than absolute measurement values for the sake of simplicity. Panelists indicated that the technologies to perform at least relative measurements have been well-developed, but the processing and quantities derived from instruments that are specific to each application need further consensus. An afternoon session further highlighted new research areas, including optical and acoustic characterization of histotripsy, tissue permeabilization, biofilm removal, drug delivery, and lithotripsy. New techniques for thermal characterization and computational modeling of microbubble clusters were also presented. During Friday's 5aBA session, there were several presentations that were relevant to the focused ultrasound community, including abstracts that directly considered focused ultrasound transducers and considerations for characterizing transducer with holography. 5aBA2. "In vivo thermal ablation control using three-dimensional echo decorrelation imaging in swine liver" (Ghahramani, University of Cincinnati) examined the correlation between 3D acoustic correlation images and ablated regions in porcine liver toward controlled ablative treatment. 5aBA3. "The impact of the central opening on nonlinear effects in ultrasound fields generated by Sonalleve V1 and V2 MR-HIFU systems" (V. Khokhlova, University of Washington and Moscow State University) compared the focal patterns and capabilities of the Sonalleve MR-HIFU V1 and V2 systems and described the HIFU-Beam simulation software, which allows time domain nonlinear simulation of annular arrays and layered media. 5aBA4. "Palpating particles using the acoustic radiation force: A new approach to magnetic particle imaging" (Zarcone, Vanderbilt University) proposed using acoustic radiation force to induce motion for magnetic particle imaging. 5aBA5. "Characterizing the steering performance of a diagnostic-therapeutic ultrasound array using measured and synthesized holograms" (Williams, University of Washington and Moscow State University) described the use of holography to characterize the surface of a linear ultrasound array with interleaving measurements to conserve time. 5aBA6. "The use of acoustic holography for simultaneous characterization of various focus steering configurations in ultrasound fields generated by multi-element phased arrays" (V. Khokhlova, University of Washington) performed harmonic and time domain holograms for annular therapeutic focused ultrasound transducers. 5aBA7. "A pipeline to enable large-scale generation of diverse 2D cardiac synthetic ultrasound recordings corresponding to healthy and heart failure virtual patients" (Burman, Katholieke Universiteit Leuven) described the use of augmentation tools for the generation of realistic myocardial velocity profiles toward the generation of large ultrasound training sets for machine learning. 5aBA8. "Contrast-enhanced ultrasound to detect active bleeding" (Schoen, Jr., Harvard Medical School and Massachusetts General Hospital) described methods and in vitro models used to establish the feasibility of microbubbles to assist with the detection of hemorrhage. 5aBA9. "Effect of acoustic output on fetal ultrasound color Doppler performance" (Huber, Duke University) described the setting of as low as reasonably achievable (ALRA) for Doppler ultrasound in neonatal imaging. 5aBA10. "Exploring the benefits of spatial and temporal block-wise filtering architectures" (Weeks, Vanderbilt University) which evaluated the use of spatial and temporal block-wise filtering ...
Meeting Report: Radiological Society of North America (RSNA) 2022 Meeting Report: Society of Neuro-Oncology (SNO) Annual Meeting and Education Day Meeting Report: Congress of Neurological Surgeons (CNS) 2022 Focused Ultrasound for Pancreatic Cancer: Trial Results Prove Safety, Initial Efficacy Visiting Scholars Work to Accelerate the Field of Focused Ultrasound


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Arbitrator's Independent Research On Steroids Results In Overturning Of Decision On Firefighter's Termination
On September 24, 2007, Travis Quesada was dismissed from his employment with Tampa, Florida Fire Rescue after a second drug test came back positive for suspicious levels of the metabolite 19-norandrosterone. This result suggested that Quesada had taken the anabolic steroid Nandrolone and had been untruthful in his responses to departmental and medical inquiries regarding steroid use.
Quesada filed a grievance, maintaining that he had not taken illegal anabolic steroids and that his use of the legal, over-the-counter supplement 17–Halo–Methyl–Dianadrone (17-HD) had produced false positive test results. After the grievance was denied, the parties went to arbitration pursuant to a collective bargaining agreement between the City and International Association of Fire Fighters, which represented Quesada. A hearing was held. Both the City and the IAFF presented expert testimony regarding anabolic steroid testing generally and the possibility that legal supplements such as 17-HD could produce a false positive result on a test for steroids.
The City's expert testified that he had become acquainted with 17-HD the day of the hearing and did not know enough about it to comment on whether it could have caused Quesada's positive test results. But he was not aware of any cases where the reporting limit of the metabolite 19-norandrosterone had been exceeded with anything other than Nandrolone or a related steroid. The IAFF's expert, on the other hand, characterized 17-HD as a legal pro-steroid that "has the potential of producing the same metabolite, the same breakdown product as the illicit Nandrolone." He noted that Quesada's levels of 19-norandrosterone were low compared to documented Nandrolone users and concluded that there was a very reasonable probability that Quesada's consumption of 17-HD caused false positive test results.
The Arbitrator issued an award holding that the City had not unjustly terminated Quesada's employment. In the award, the Arbitrator acknowledged that she had conducted independent research on the supplement 17-HD. She noted that Vyotech – the company that produces 17–HD – states on its website that the supplement will not show up on drug tests. She attached several pages of information, apparently gathered from Vyotech's website and a dietician acquainted with 17-HD. These pages contained an assessment of 17-HD's ingredients and the dietician's opinion that "17-HD is just a bunch of herbs with a name that tries to sound like a prohormone or even a potent steroid."
After mentioning this outside research, the Arbitrator concluded that Quesada's positive test result could not have been caused by 17-HD, that his responses regarding steroid use were untruthful, and that he had not been unjustly terminated. Quesada filed a motion in court to vacate the arbitration award because the Arbitrator had conducted independent research.
The Florida Court of Appeals overturned the Arbitrator's award. The Court noted that Florida law required that an arbitrator's award be overturned "when there is misconduct by an arbitrator which prejudices the rights of any party." In the Court's judgment, "the Arbitrator's independent research constitutes misconduct because arbitration panels should not, in the course of their deliberations, go outside the evidence presented to them."
The Court also found that "Quesada has been prejudiced by the Arbitrator's misconduct because her independent research yielded information not only different from any of the evidence in the record but also damaging to Quesada's case. We note that the collective bargaining agreement did not provide that the Arbitrator was free to conduct independent research. Accordingly, we vacate the Arbitrator's award."
Quesada v. City of Tampa, 2012 WL 2614918 (Fla .App. 2 Dist. 2012).
Note: Oddly, the Court did not describe what should happen next in Quesada's challenge to his discipline. Presumably, it will be up to a trial court to decide whether Quesada should have his discharge overturned, whether the case should be sent back to the original arbitrator for a new ruling (excluding her "independent research"), or whether the case should be sent to a new arbitrator.
Categories: Arbitration Decisions, Drug Testing, Public Safety Labor News, Termination
| Tags: steroids
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This Chinese fried rice recipe is a healthy rice recipe.
It is not overly spiced and you can add the vegetables of your choice.
Add as many vegetables and as much quantity as you and your family like. A good healthy way to eat your vegetables.
As the vegetables are not overcooked, they retain their nutrients. They are also crunchier when you eat.
When you have the rice already cooked, you can mix up the fried rice within a few minutes.
- 1 tsp each - soya sauce, tomato sauce, hot chilly sauce.
- pour 3 table spoon oil and first fry the spring onion, then beans, carrot, cabbage and finally capsicum and later sliced baby corn.
- Once cooked, add a pinch of ajinomoto, and the sauces.
- Mix well and add salt .
- Wash and cook the rice by adding 1.5 glasses of water and salt to taste. If cooking in pressure cooker wait for one whistle.
- Afterwards add this cooked rice to the cooked vegetables. Mix well and serve.
You can take a tube type cylindrical dabba, and fill the rice and later do topsy turvy and you will get the rice into a shape.
Variations you can do with this Chinese rice recipe.
- You can add pudina(mint) and coriander(hara dhania/cilantro) if you like the taste while frying the vegetables.
This is a favorite Chinese dish at home.
This fried rice looks really different from what we get here. There are lots of Chinese restaurants at my country and I have tried variety of Chinese dishes from there. I will follow this recipe to prepare perfect Chinese fried rice.


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Asean foreign ministers expressed serious concerns to China over South China Sea developments: Vivian
Singapore's Foreign Minister Vivian Balakrishnan said Asean ministers had expressed serious concerns to China over recent South China Sea developments on June 14, 2016.PHOTO: MFA
Jun 14, 2016, 7:39 pm SGT
http://str.sg/4UgC
SINGAPORE - Singapore's Foreign Minister Vivian Balakrishnan said Asean ministers had expressed serious concerns to China over recent South China Sea developments at the Special Asean-China Foreign Ministers' Meeting held in the Chinese city of Kunming on Tuesday (June 14).
The meeting between the Asean foreign ministers and Chinese Foreign Minister Wang Yi in Kunming, in south-western Yunnan province, was co-chaired by Dr Balakrishnan, the Singapore Ministry of Foreign Affairs (MFA) said in a press statement. Singapore is the current Asean-China dialogue relations co-ordinator.
According to the MFA, the foreign ministers discussed recent developments in the South China Sea and highlighted the need to "intensify efforts to achieve further progress in the implementation of the Declaration on the Conduct of Parties in the South China Sea and substantive development of the Code of Conduct".
The MFA said Dr Balakrishnan "noted the serious concerns expressed by the Asean Foreign Ministers over the developments on the ground" as he called on Asean and China to "continue working together to maintain the peace and stability of the South China Sea".
"Minister Balakrishnan also reiterated Singapore's long-standing position on the issue and underscored the importance of the peaceful resolution of disputes with full respect for legal and diplomatic processes, as well as the right of freedom of navigation and over-flight under international law, including the 1982 United Nations Convention on the Law of the Sea (UNCLOS)," the statement added.
Tuesday's meeting comes as fears of conflict rise over China's construction of military facilities on islands in the South China Sea, and amid freedom-of-navigation and overflight missions by the United States.
Tensions have also been heightened by an impending United Nations tribunal ruling over an arbitration case on China's South China Sea claims, which the Philippines brought to the court in 2013.
A decision is set to be announced in weeks, with many expecting the ruling to go against China, which claims almost all of the sea.
China has slammed the arbitration and refused to take part in proceedings, insisting instead on direct negotiations between claimant states. The other claimants to the disputed waters are Taiwan, Vietnam, Brunei and Malaysia.
Aside from the South China Sea issue, the two sides also reviewed the progress of Asean-China relations and discussed the future direction and priority areas of cooperation, the MFA said.
In addition, the foreign ministers also discussed the preparations for the Asean-China Commemorative Summit that will take place in September 2016 in Laos that will celebrate 25 years of dialogue relations, it added.
"Minister Balakrishnan reaffirmed Singapore's commitment to work closely with Asean member states and China to advance the mutually beneficial relationship," the MFA said.
Dr Balakrishnan returns to Singapore on Tuesday.
VIVIAN BALAKRISHNAN