text:
Impact of Early Life Stress on Reward Circuit Function and Regulation
Jamie L. Hanson, Alexia V. Williams, Debra A. Bangasser, Catherine J. Peña
Early life stress – including experience of child maltreatment, neglect, separation from or loss of a parent, and other forms of adversity – increases lifetime risk of mood, anxiety, and substance use disorders. A major component of this risk may be early life stress-induced alterations in motivation and reward processing, mediated by changes in the nucleus accumbens (NAc) and ventral tegmental area (VTA). Here, we review evidence of the impact of early life stress on reward circuit structure and function from human and animal models, with a focus on the NAc. We then connect these results to emerging theoretical models about the indirect and direct impacts of early life stress on reward circuit development. Through this review and synthesis, we aim to highlight open research questions and suggest avenues of future study in service of basic science, as well as applied insights. Understanding how early life stress alters reward circuit development, function, and motivated behaviors is a critical first step toward developing the ability to predict, prevent, and treat stress-related psychopathology spanning mood, anxiety, and substance use disorders.
Frontiers in Psychiatry
https://doi.org/10.3389/fpsyt.2021.744690
early life stress (ELS)
nucleus accumbens (NAc)
ventral striatum
ventral tegmental area (VTA)
10.3389/fpsyt.2021.744690
Dive into the research topics of 'Impact of Early Life Stress on Reward Circuit Function and Regulation'. Together they form a unique fingerprint.
Psychological Stress Medicine & Life Sciences 100%
Reward Medicine & Life Sciences 97%
Child Abuse Medicine & Life Sciences 47%
Nucleus Accumbens Medicine & Life Sciences 43%
Substance-Related Disorders Medicine & Life Sciences 35%
Anxiety Medicine & Life Sciences 28%
Ventral Tegmental Area Medicine & Life Sciences 24%
Psychopathology Medicine & Life Sciences 19%
Hanson, J. L., Williams, A. V., Bangasser, D. A., & Peña, C. J. (2021). Impact of Early Life Stress on Reward Circuit Function and Regulation. Frontiers in Psychiatry, 12, [744690]. https://doi.org/10.3389/fpsyt.2021.744690
Hanson, Jamie L. ; Williams, Alexia V. ; Bangasser, Debra A. et al. / Impact of Early Life Stress on Reward Circuit Function and Regulation. In: Frontiers in Psychiatry. 2021 ; Vol. 12.
@article{ffd080eb12d84584a320356341e7abfa,
title = "Impact of Early Life Stress on Reward Circuit Function and Regulation",
abstract = "Early life stress – including experience of child maltreatment, neglect, separation from or loss of a parent, and other forms of adversity – increases lifetime risk of mood, anxiety, and substance use disorders. A major component of this risk may be early life stress-induced alterations in motivation and reward processing, mediated by changes in the nucleus accumbens (NAc) and ventral tegmental area (VTA). Here, we review evidence of the impact of early life stress on reward circuit structure and function from human and animal models, with a focus on the NAc. We then connect these results to emerging theoretical models about the indirect and direct impacts of early life stress on reward circuit development. Through this review and synthesis, we aim to highlight open research questions and suggest avenues of future study in service of basic science, as well as applied insights. Understanding how early life stress alters reward circuit development, function, and motivated behaviors is a critical first step toward developing the ability to predict, prevent, and treat stress-related psychopathology spanning mood, anxiety, and substance use disorders.",
keywords = "development, early life stress (ELS), nucleus accumbens (NAc), reward, ventral striatum, ventral tegmental area (VTA)",
author = "Hanson, {Jamie L.} and Williams, {Alexia V.} and Bangasser, {Debra A.} and Pe{\~n}a, {Catherine J.}",
note = "Funding Information: This work was supported by R00 MH115096 (CP), BBRF Young Investigator Award 28627 (CP), NSF Award IOS-1929829 (DB), R01 DA049837 (DB), and T32DA007237 (AW). Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Hanson, Williams, Bangasser and Pe{\~n}a.",
doi = "10.3389/fpsyt.2021.744690",
journal = "Frontiers in Psychiatry",
publisher = "Frontiers Research Foundation",
Hanson, JL, Williams, AV, Bangasser, DA & Peña, CJ 2021, 'Impact of Early Life Stress on Reward Circuit Function and Regulation', Frontiers in Psychiatry, vol. 12, 744690. https://doi.org/10.3389/fpsyt.2021.744690
Impact of Early Life Stress on Reward Circuit Function and Regulation. / Hanson, Jamie L.; Williams, Alexia V.; Bangasser, Debra A. et al.
In: Frontiers in Psychiatry, Vol. 12, 744690, 20.10.2021.
T1 - Impact of Early Life Stress on Reward Circuit Function and Regulation
AU - Hanson, Jamie L.
AU - Williams, Alexia V.
AU - Bangasser, Debra A.
AU - Peña, Catherine J.
N1 - Funding Information: This work was supported by R00 MH115096 (CP), BBRF Young Investigator Award 28627 (CP), NSF Award IOS-1929829 (DB), R01 DA049837 (DB), and T32DA007237 (AW). Publisher Copyright: © Copyright © 2021 Hanson, Williams, Bangasser and Peña.
N2 - Early life stress – including experience of child maltreatment, neglect, separation from or loss of a parent, and other forms of adversity – increases lifetime risk of mood, anxiety, and substance use disorders. A major component of this risk may be early life stress-induced alterations in motivation and reward processing, mediated by changes in the nucleus accumbens (NAc) and ventral tegmental area (VTA). Here, we review evidence of the impact of early life stress on reward circuit structure and function from human and animal models, with a focus on the NAc. We then connect these results to emerging theoretical models about the indirect and direct impacts of early life stress on reward circuit development. Through this review and synthesis, we aim to highlight open research questions and suggest avenues of future study in service of basic science, as well as applied insights. Understanding how early life stress alters reward circuit development, function, and motivated behaviors is a critical first step toward developing the ability to predict, prevent, and treat stress-related psychopathology spanning mood, anxiety, and substance use disorders.
AB - Early life stress – including experience of child maltreatment, neglect, separation from or loss of a parent, and other forms of adversity – increases lifetime risk of mood, anxiety, and substance use disorders. A major component of this risk may be early life stress-induced alterations in motivation and reward processing, mediated by changes in the nucleus accumbens (NAc) and ventral tegmental area (VTA). Here, we review evidence of the impact of early life stress on reward circuit structure and function from human and animal models, with a focus on the NAc. We then connect these results to emerging theoretical models about the indirect and direct impacts of early life stress on reward circuit development. Through this review and synthesis, we aim to highlight open research questions and suggest avenues of future study in service of basic science, as well as applied insights. Understanding how early life stress alters reward circuit development, function, and motivated behaviors is a critical first step toward developing the ability to predict, prevent, and treat stress-related psychopathology spanning mood, anxiety, and substance use disorders.
KW - development
KW - early life stress (ELS)
KW - nucleus accumbens (NAc)
KW - reward
KW - ventral striatum
KW - ventral tegmental area (VTA)
U2 - 10.3389/fpsyt.2021.744690
DO - 10.3389/fpsyt.2021.744690
JO - Frontiers in Psychiatry
JF - Frontiers in Psychiatry
Hanson JL, Williams AV, Bangasser DA, Peña CJ. Impact of Early Life Stress on Reward Circuit Function and Regulation. Frontiers in Psychiatry. 2021 Oct 20;12:744690. doi: 10.3389/fpsyt.2021.744690


text:
It Was You Charlie not quite whimsical enough: review
The movie, filmed in Toronto, follows the diminutive Abner (Michael D. Cohen).
By Bruce DeMaraCulture Reporter
Thu., Aug. 14, 2014timer2 min. read
It Was You Charlie
Starring Michael D. Cohen, Aaron Abrams, Emma Fleury. Written and directed by Emmanuel Shirinian. 79 minutes. At TIFF Bell Lightbox. 14A.
Who's Charlie?
The title, It Was You Charlie, does raise the question since none of the characters in the film are actually named Charlie.
It's possible that writer/director Emmanuel Shirinian meant it as a bit of whimsy to match the tone of the film, which lies somewhere in the amorphous realm known as dramedy.
Unfortunately, the film feels a little off-kilter, leaning more heavily toward drama. That isn't necessarily a bad thing though a few more moments of levity would have been welcome.
The movie, filmed in Toronto, follows the diminutive Abner (Michael D. Cohen), once an artist and teacher, now living a sad-sack existence as a doorman on the night shift who's clearly in deep psychic distress. (How he can afford such a great apartment on his salary is a little hazy.)
As events unfold in flashback, it seems that two things are eating him alive: a serious car accident which — it'll take a long time to reveal — had dire consequences for another person and secondly, a rift with his brother Tom (Aaron Abrams), who took away the woman Abner had a thing for.
How brooding over a diorama of the accident scene in his living room is going to help Abner resolve the one conflict is never made clear. Oh and also, two menacing guys wearing sunglasses seem to be following him around.
Abner encounters Zoe (Emma Fleury), a bubbly cab driver who seems to be into him, but he's too traumatized to take a ride, so to speak, since the accident.
Cohen, who could easily play actor Danny DeVito in a biopic should the need arise, plays Abner with a degree of melancholy that borders on excruciating, making his eventual redemption a little hard to swallow.
Abrams' portrayal of the older, taller and much better looking brother Tom is actually more sympathetic than it ought to be, since Abner is the ostensible protagonist.
Shirinian, a homegrown filmmaker making his feature-length film debut, is clearly talented behind the camera. It's in the screenwriting that he falters.
It Was You Charlie's uneven blend of drama and comedy makes for competent but far from pleasing cinema. Better luck next time.

redpajama_set_name: RedPajamaCommonCrawl


Unique points of view and inspirational true stories.
Matt Frey's wonderful insight will instantly brighten your day!
What this young man from Australia wants people to know about autism . . .
Thirty-year-old Sean Sullivan of SoCal is on a mission to help others like himself enjoy the same educational benefits as their neurotypical counterparts.
For most of his life, Rory Patton didn't know he had Asperger's. Our in-depth interview with him offers unique insight that will educate and inspire you.
When Shawn began dating the mom of a little boy with autism, he had no idea how much his life would be changed. You won't want to miss his wonderful essay, titled, "Tree"!
Ashley's detailed description of her experiences growing up with autism (then undiagnosed), her stories, and her drawings offer unusual insight into this beautiful mind.


Together the four founding member organisations, Rethink Mental Illness, Support In Mind Scotland, Hafal, and MindWise, have worked for over 40 years to provide services, information, and advice to support anyone affected by mental illness.
We run over 400 services and 200 volunteer support groups in communities around the UK. Over 90,000 people rely on our organisations every year to help them get through crises, live independently and realise they are not alone. Last year our health information was accessed online over 3.6 million times.
Despite this extensive work we know many more people need our help. Mental illness affects more people every year than cancer or heart disease. One in four of us in the UK will be affected by a mental health problem in any given year. Severe mental illness can affect anyone, although it often emerges during adolescence or in your early 20s.
Living with a mental health condition can affect many aspects of your daily life, from your physical health to your home, your work and managing money. The impact of poor mental health can be reduced if you benefit from early intervention and support. But it's still the case that you're more likely to receive the urgent support you need if you have broken your leg than if you experience a crisis because of a mental health problem.
By supporting Mental Health UK, you can help us change this.
Lloyds Banking Group launched a new two-year partnership with Mental Health UK in January 2017. Through this partnership, Lloyds Banking Group aims to promote awareness of the link between mental health and money problems, encourage discussion between customers and colleagues and raise at least £2million per year in offices and branches across the UK.
You can read more about this initiative on the Mental Health UK website.
The Mental Health and Money project aims to support people with a mental illness who have mental health difficulties. We spoke to Beth about her experience of mental illness and debt, and asked her why the Mental Health and Money project is so important.
Beth first experienced anxiety and depression when she was very young. In 2010 she contracted glandular fever which left her feeling very depressed, not wanting to get out of bed and experiencing panic attacks. Beth found her issues made work challenging and subsequently had to leave. Her family were very accepting and have supported her throughout.
Beth admits that she's always had problems with spending. Even as a little girl money would burn a hole in her pocket. At university Beth found having access to all of her student loan money at once made this worse. "It was like having disposable money." When Beth started work she continued to spend money she didn't have. "When I felt depressed, I wanted to spend money to make myself feel better." This could be anything from buying a cup of tea to a new laptop. Getting a credit card enabled Beth to accumulate another £4,000 of debt. However, she avoided telling anyone, particularly her parents.
Beth describes her anxiety at that time as "horrible". She became obsessed with how to increase her income, felt constantly sick and was unable to sleep through worry. Having debts felt like the end of the world.
Eventually she told her partner her big secret. He was very kind and reassured her that they could get through this together. Beth feels that without his understanding and help she wouldn't have been able to deal with the situation. Her partner created a spreadsheet to calculate Beth's outgoings so that she would know her weekly spending limit. Beth has also found that setting herself a weekly cash allowance has helped her keep her spending under control. She has been surprised by how her mindset has changed when you can see how much you have available to spend.
When Beth feels down or anxious she still feels the need to spend but has the discipline to give her credit card to her partner to stop her from comfort spending.
Beth feels that her relationship with money is far better; her partner says it has improved dramatically.
Beth's key piece of advice to others would be to confide in someone you trust. This can really take the pressure off and help you to see things more clearly. Beth welcomes the Lloyds Banking Group and Mental Health UK initiative to support people with mental health and money problems. She feels that this is a great opportunity to raise awareness and provide support to people who experience these combined issues.


An insight into Malaysian culture through cuisine.
Malaysia is a multiracial country: Malays, Chinese, Indians, and numerous indigenous people coexist in harmony. Despite these racial differences, we do have one thing in common: a love for food.
Food festivals have received a lot of hype from Malaysians in the last few years. They're definitely the best place to try new food and drinks from small businesses and start-ups.
However, I personally think these festivals are overrated; the food is overpriced and portions are usually smaller than average. But for the sake of a good time and some cool Instagram shots, food festivals are still one of my must-go-to events of the year.
About 60% of Malaysians are Muslims who fast during the month of Ramadan. That's why every day for the whole month, Ramadan bazaars are held all over the country. Any Malaysian would know how crowded these bazaars can get, especially a few hours before Muslims break their fast, or iftar.
To me, the best thing about buying food at bazaars is that I will always have leftovers to eat for sahur, which is a pre-dawn meal before fasting the whole day.
A smaller-scale version of Ramadan bazaars, night markets or Pasar Malam, are held a few times a week or even every day, depending on the location. Where I'm from, these markets are held every Tuesday and Friday nights.
When Malaysians are too lazy to cook, this is definitely the go-to place. It's also one of the few places I know where I can get my yong tau foo fix.
Carnivals are common all over the world, but in Malaysia, carnivals are typically fundraising events for the school. Instead of money, vouchers would be used as a means of exchange.
Back in my high school, any school club and organization was allowed to open up a booth and sell food and drinks. I believe it's the most anticipated event of the school year.
What Malaysians truly take pride in is Malaysian food, which could be both traditional dishes or a fusion of several cuisines. For the time being, I hope this gives you an insight into what my culture is all about.


text:
Најкориснији играч НБА ( или скраћено -{NBA MVP}-) годишња је награда која НБА лига додељује од 1956. играчу са најбољим учинком током регуларне сезоне. Награђеном се уручује Трофеј Морис Подолоф, назван по првом председнику НБА лиге (од 1946. до 1963. године). Једини играч који је ову награду освајао чак шест пута је Карим Абдул Џабар, док Бил Расел и Мајкл Џордан деле друго место са по пет трофеја.

Стефен Кари је једини играч у НБА историји који је освојио ову награду једногласно 2016. године. До сада су три играча са тла Европе освајала награду: Дирк Новицки (Немачка), Јанис Адетокумбо (Грчка) и Никола Јокић (Србија).

Начин избора
Укупно 125 спортских новинара бира по три играча (првог, другог, трећег, четвртог и петог). Сваки играч добија бодове по принципу; први десет бодова, други седам, трећи пет, четврти три и пети један. Играч са највише освојених бодова добија признање.

Списак награђених и њихови тимови

Легенда:

Вишеструки победници

{| class="wikitable"
|-

Референце

Спољашње везе

 Сви победници МВП награде на сајту ЕСПН
 Званични сајт НБА лиге

Награде у НБА

redpajama_set_name: RedPajamaWikipedia


text:
Dept. of Finales
Life Without Audience
By Nick Paumgarten
Vin Scelsa finished taping the last episode of "Idiot's Delight," his long-running free-form radio program, at 2 P.M. on the first day of May. He recorded it in a home studio stocked with thousands of CDs and LPs, and then submitted it, via Dropbox, to WFUV, the Fordham University station that has broadcast the show since 2001. He hadn't done it live for years—he'd come to appreciate the opportunity to correct for mistakes and memory lapses.
One hallmark of the show had been the occasional sound, amid his lengthy on-air peregrinations, of his shuffling through papers or jewel cases in search of an elusive fact or name. In the show he'd just finished, which included a tribute to his old colleagues at WNEW-FM, he'd neglected to mention one of them. "I forgot Dave Herman," Scelsa said. It was a little after 4 P.M., and he was still puttering around the studio. The show wasn't to air until the following night. So it was that Scelsa's last act as a d.j. was to patch in Herman's name. "Of course, with Dave Herman it gets complicated," he said. Herman, who hosted the morning show on WNEW in the seventies, died last year, while in jail awaiting trial on charges related to soliciting sex from a seven-year-old girl. Maybe it was better to forget about Dave Herman.
Scelsa, who is sixty-seven, lives in Roseland, New Jersey, near a pair of golf courses, in a quiet neighborhood that suggests the habitat not of a rock-and-roll magpie but of bygone listeners—suburban longhairs in bongy basements and Camaros, getting their education over the airwaves from the curates of FM. (The intro to his program used to imagine a different audience: "Attention, artists, cabdrivers, and melancholy waitresses . . .") He and his wife, Freddie, whom he met in high school, have owned the house since 1980. Her family had a chain of jewelry stores in New Jersey, and her work eventually enabled Scelsa to be a stay-at-home d.j. and dad. (Their daughter is now thirty-four.) The house abuts some woods. A pair of wild turkeys strutted at the edge of the trees. "We don't go out there," Scelsa said. "We're scared to death of the ticks."
He'd been thinking for a while about retiring. "I worried about the inability to keep up with new things," he explained. "I didn't want to succumb to nostalgia."
Free-form radio means the d.j. plays whatever he likes and—notably, in Scelsa's case—talks about whatever he wants for as long as he wants. There is no official repository of Scelsa's old shows. But diehards have collections; a fan club of sorts, called Idiot's Delight Digest, has been convening since 1995, when Scelsa was fired by K-Rock (WXRK). He said, "It's cool to think that whatever intelligent life there is out there may one day come upon 'Idiot's Delight' and think, This is what life is like on the blue planet." Life is digressive here.
His resistance to automated playlists and the edicts of program directors was so strong that he couldn't program a show even for himself. "I can't plan it out beforehand," he said. Still, he'd thought about his last one, and while the farewell wouldn't be Letterman scale, he had a few moves in mind. For an opener, he chose Sopwith Camel's "Hello Hello," the first thing he'd played on his first night on the air, on WFMU, at Upsala College, in 1967. It's not unthinkable that you'll never hear that one on the radio again, anywhere. He also had a closer: he'd come across his copy of Lou Reed's collected lyrics (inscribed by Reed: "To a great man") and opened it to "Goodnight Ladies."
"It's perfect," Freddie said.
After "Goodnight Ladies," Scelsa signed off: "Thanks for your ears. I love you all."
Two weeks later, Scelsa was still trying to adjust. He'd recently had his first retirement dream. Scelsa said, "Someone in the dream suggested a piece of music: 'You can use that on Saturday.' 'Oh, my God, no!' I realized I no longer had a show. I woke up very upset. And then I had the experience this week of listening to new music and finding that I really liked it and yet had no way of doing anything with it. It was such an empty feeling."
The track, by the songwriter Stella Peach, was called "Ah! So This Is How It Feels!" The title resonated with him. "I said, 'I gotta do something with this.' My daughter-in-law—my daughter's wife—she works in the avant-garde puppet world. I wanted to make a copy and send it to her." But he didn't. He was afraid of becoming the aging parent who sends newspaper clippings. "It's not just about sharing," he reflected. "It's more selfish than that. It's 'Here's what I found. Look at how cool I am.' "
It's also nice to have nothing to do. "The other day, when I learned that B. B. King had died, I felt relieved not to have to deal with that on the air," he said. Musicians keep dying, and it is only going to get worse. "Sometimes it felt like the shows were becoming a deathwatch." In June, there will be a tribute to Scelsa at City Winery, with performances by a number of his favorite artists. He gave the organizers a wish list. Presumably, he'll talk some. ♦
Nick Paumgarten has been a staff writer at The New Yorker since 2005.
Disc Jockeys (D.J.s)
Inside Marc Maron's Garage
The success off Maron's "WTF" podcast depends, in large part, on the aura of nostalgia and intimacy of his makeshift home studio.
By Simon Parkin
Party of One
Michael Savage, unexpurgated.


China Hot Rolled 201 202 304 Stainless Steel Sheets Price, ... 0.6mm Thick 201 Stainless Steel Plate with Discount Price. ... Quality Stainless Steel Metal Strips manufacturers & exporter - buy 304 Full Hard Stainless Steel Metal Strips 0.2mm - 0.6mm Cold Rolling from China manufacturer. No.4 201 Steel sheet Thickness Tolerance.
Galvanized Circles, Wholesale Various High Quality Galvanized Circles Products from Global Galvanized Circles Suppliers and Galvanized Circles Factory,Importer,Exporter at Alibaba.
The top supplying countries are China (Mainland), India, and Taiwan, which supply 92%, 3%, and 1% of d type door handle respectively. D type door handle products are most popular in Mid East, Western Europe, and Eastern Europe.
erw welded price 25*25mm square steel tube manufacturer in China ,we are professional erw welded price 25*25mm square steel tube suppliers and distributor ,if you need erw welded price 25*25mm square steel tube price and application ,please contact us.
We list many of China's best FRICTION HINGE manufacturers and also have a number of other good companies that supply equipment & related supplies to dealers and distributors/vendors. Ranking of China suppliers manufacturing FRICTION HINGE can be filtered by their reviews, recommendations, price/cost and overall quality rating.
Din934 Hex Nuts Products from Chinese suppliers. ECVV provides Din934 Hex Nuts product China Sourcing Agent service and supply chain service to protect the product quality and payment security.


I have never been a fan of reality TV and would be hard-pressed to watch any programme where people try to meet a suitable partner or spend weeks cooped up in a fishbowl of a room trying to see how they get along. But one show, which has caught my attention is Den D (translatable as D-Day but known in English as Dragon's Den). If you're familiar with the programme, you'll know it's a show where entrepreneurs try to persuade investors to put money into their start up businesses.
Photo: Czech TV The show's attraction is the success stories – genuinely good ideas that get produced –versus ideas that fail miserably and don't get a single crown. The first can be fairly inspirational; the second, often in the form of a stammering guest with a screw loose and convincing no one, can be painful to watch.
Just this week Czech TV began its third series of the popular show, featuring a panel of potential investors like the tourism industry's Tomio Okamura. He and others lend an edge to the programme and a no-nonsense approach: one should genuinely be scared to appear before them unless you've crunched the numbers, crunched them again and know a lot about your product.
Photo: Czech TV You have to be able to convincingly explain why you think your idea will be a success. And you have to have panache. If you don't, if you can't, if you come off as a snake-oil salesman or as a lunatic, you're in for a gruelling from the panel you (and viewers) won't soon forget. It'll be polite but very, very brutal and not over fast.
In Thursday's episode, for example, one would-be businessman was told by increasingly annoyed panel members that he was a 'cvok' (a nut), or that he was either from Alpha Centauri or Mars or Venus. His mistake? Having wasted their time with a fairly ugly plastic toy system that won't be rivalling Lego anytime soon. As a potential entrepreneur he unfortunately showed painfully little business sense. Another guest, though, succeeded in securing funds for his project in return for a share in his company, a kind of hobby horse that wasn't a bad idea but aesthetically left a lot to be desired. Too bad the investors didn't press for an improved design.
Photo: Czech TV But my favourite to appear on Den D so far had to be a lady planning to launch a kind of Czech version of McDrive, only with traditional Czech food and traditional recipes. Most of the panel appeared quite happy to invest in the idea, which, if successful, would feature outlets along major routes. But the women behind the project, who was wearing Czech kroje (historic dress) apparently 'didn't get the memo'. Offered money by the investors, she told them she would give them five percent in profits but in no way part of the company.
In other words, the panel quickly deduced, they would act as bankers offering a convenient loan but not get much in return. And that ended any potential deal. Tomio Okamura was emphatic that part of the thrill of investing was in watching projects successfully grow – so not only in making a profit. But it was a no-go and that was the end of it. She left empty-handed, unwilling to budge, it was fascinating nonetheless.


text:
Reed City falls to Big Rapids in district championship match
REMUS — The Big Rapids High School volleyball team defeated Reed City, 3-0, on Thursday night at Chippewa Hills High School to complete a perfect 6-0 sweep in district play and pick up a Class B district championship.
Big Rapids took the first set 25-17.
The Cardinals came out on fire in the second set, running out to a 6-0 lead before Reed City could muster a point. It was 25-14 in the second.
"They were able to get ahead in all three of those games," Reed City coach Don Patterson said. "They were then able to pick up their serving intensity and you can take a little more chances when you've got a lead, and when you don't you tend to be a little more tentative and that was the difference. They served a little better and played a little tougher than us (Thursday). I think that was the big difference."
Reed City fell behind 16-10 in the third game. The Coyotes fought back late in the set with three kills from Ally Yarger, but the Cardinals were simply too tough, taking the 25-18 third-set victory.
Alison Schermerhorn led the Coyotes with 20 digs, two aces and five blocks, while Skiler Brigham added five kills and two blocks. Hanna Price chipped in 14 digs, while Jordyn Storch put up 10 assists, one ace and five digs.
Coyotes scored a 3-0 victory over Clare in Wednesday's semifinal round 25-18, 25-17, 25-18.
The Pioneers made things interesting in the third game, going on a run of their own to cut a Coyote lead to 22-17, but Patterson called a timeout to calm his squad down as it looked to punch a ticket to the district final.
"I just said that we need to make one good pass here and we talked about what our offense was and made sure that we knew who we were going to hit," he said. "We got a ball to Megan Donley and said let's get her a good ball to hit and she put it away."
The shot by Donley sparked a 3-1 finish by the Coyotes to take the third set.
Schermerhorn contributed nine aces, four kills and 20 digs in the contest while Yarger added 10 kills, 16 digs and two aces. Liza Emington and Storch dished out 15 and 12 assists, respectively. Price added 20 digs and Donley and Brigham chipped in six kills apiece.
"Our serve received has really, really stepped up in the last few weeks," Patterson said after the Clare game. "Hanna Price and Alison Schermerhorn are just passing really well right now. Volleyball is just a game of serve and serve receive."


Housed beneath protective hardened mineral glass lies the traditional white Railway dial as seen in train stations throughout Switzerland. Black stick hands and hour markers are off set by the much revered red lollipop second hand.
Set upon a black rubber strap which has been made from recycled materials and castor oil, the Essence watch is fastened by a secure black buckle.
Powered by Swiss Quartz movement and water resistant up to 30 meters, this watch comes complete with a two year guarantee and official Mondaine packaging. The Essence watch is packaged with a recycled PET pouch.
For us to size your new Mondaine Essence watch as accurately as possible, please take a look at our downloadable Watch Sizing Guide.


Skating At is a pop-up Ice Skating festival set up in iconic and picturesque locations around Australia.
Centred around a world class ice skating rink, Skating At is a festival of food, drinks and entertainment all conveniently located in the heart of the city. This family friendly event is ideal for people of all ages and skill levels who want to have SNOW much fun over the winter!
Whether you're getting the family together for an extra-ordinary outing over the Winter school holidays… Or you want to spoil that special someone with an unique date night experience… Or even just get your mates together for an exciting adventure on the ice! Skating At is the COOLEST place to be this Winter!
These pop-up ice rinks are only in town for a limited time.
Don't miss out, book below and be sure to follow our socials for exciting updates and competitions!


This is a ring of tissue in the lower esophagus located at or near the border of the lower esophageal sphincter. It is also known as a lower esophageal ring. Being confined to the mucosa, it differs from an inflammatory (peptic) stricture, which involves all layers of the esophagus.
Schatzki's Ring is always associated with a hiatal hernia.
Most are over 20 millimeters in diameter and are asymptomatic. Solid food dysphagia (difficulty swallowing solid food) most often occurs with rings less than 13 mm in diameter. The dysphagia is usually intermittent and is not progressive.
Large, poorly digested food such as steak are most likely to cause problems. Drinking extra liquids or regurgitation may relieve the obstruction.
Lower esophageal rings may be diagnosed clinically and confirmed by barium swallow (a radiological study to assess swallowing) and upper endoscopy (using a tube to enter the mouth in order to view the esophagus and stomach).
The majority of symptomatic patients can be treated permanently with the passage of large (17 to 20 millimeter) dilators, which disrupt the mucosal ring. Single dilations of symptomatic lower esophageal rings are safe, easily performed, and well tolerated. Recurrences can be successfully treated by repeated dilations.
What is the approximate size of the mucosal ring?
Will it cause dysphagia (difficulty swallowing)?
Is there a risk of recurrence?
Can the ring be treated again if there is a recurrence?
What is the likelihood of a permanent cure?


text:
Matteo Fiorini (born 10 February 1978) is a Sammarinese politician who was a Captain Regent (head of government for San Marino) for the October 2011 to April 2012 political term. The post was shared with Gabriele Gatti. He also served with Enrico Carattoni as Captain Regent from October 2017 until April 2018.

References

1978 births
People from the City of San Marino
Captains Regent of San Marino
Members of the Grand and General Council
Living people


Welcome to the New Atlantic Medical Supply Corporate Website.
Founded in 2002, Atlantic Medical Supply has served over 500,000 valued customers worldwide including The U.S. Government and Military, Fortune 500 Companies, general practitioners, clinics, hospitals, the entertainment industry as well as the general public. Our new state-of-the-art website offers thousands of products with color photos and detailed descriptions to make ordering quick and easy. We use High Level SSL Encryption to ensure your security. Our skilled customer service representatives are available to assist you 9am - 4pm EST via phone, email or live online support.


text:
/* @classImport:[fixtures/B, fixtures/C, fixtures/A] */
var BCA;

redpajama_set_name: RedPajamaGithub


NPP is a member of the BJP floated platform of non-Congress parties, North East Democratic Alliance.
GUWAHATI: Eighteen BJP leaders in Arunachal Pradesh who were denied party tickets, including the state home minister Kumar Waii and tourism minister Jarkar Gamlin, joined the Conrad Sangma-led National People's party (NPP).
Those who switched camps include the BJP's state general secretary Jarpum Gamlin and MLAs Thangwang Wangham, Tapuk Taku, Pani Taram, Pangka Bage, Wangling Lowandong, Kardo Nyigyor and Tsering Jurmey.
It has decided to contest the assembly polls in Arunachal Pradesh and contest all 25 Lok Sabha seats in the eight states across the Northeast.
NPP leader Thomas Sangma said the party will field 30-40 candidates in the state polls.


text:
1 hour ago ago
Kaine Suggests 'Other Paths' To Push Voting Rights Legislation Through Senate
There's No Such Thing As A Moderate Republican In 2021. It Wasn't Always This Way.
Former New York governor and, later, Vice President Nelson Rockefeller (seen here with President Nixon) was one of many Republicans from an earlier era who were moderate or even progressive. (Photo by © CORBIS/Corbi... Former New York governor and, later, Vice President Nelson Rockefeller (seen here with President Nixon) was one of many Republicans from an earlier era who were moderate or even progressive. (Photo by © CORBIS/Corbis via Getty Images) MORE LESS
By Peter Dreier
August 17, 2021 11:37 a.m.
This article is part of TPM Cafe, TPM's home for opinion and news analysis.
Some pundits and politicians are hailing the Senate's approval of a bipartisan infrastructure bill — with all 50 Democrats and 19 Republicans voting in support — as evidence that bipartisanship is possible and that there's no need to scuttle the filibuster rule that requires 60 votes to pass any legislation.
After the vote, Minority Leader Mitch McConnell (R-KY) proclaimed, "I was proud to support today's historic bipartisan infrastructure deal and prove that both sides of the political aisle can still come together around common-sense solutions."
"This is what it looks like when elected leaders take a step toward healing our country's divisions rather than feeding those very divisions," said Sen. Kyrsten Sinema (D-AZ), who led the negotiations for the Democrats.
Here's how the Los Angeles Times described how the infrastructure bill was passed: "After months of negotiation among President Biden, Democrats and a group of moderate Republicans to forge a compromise, the Senate voted 69 to 30 in favor of the legislation."
The Times then listed the "ten centrist senators" — five Republicans and five Democrats — who worked to craft the bill: Republicans Rob Portman (OH), Bill Cassidy (LA), Susan Collins (ME), Lisa Murkowski (AK), and Mitt Romney (UT) and Democrats Jeanne Shaheen (NH) Jon Tester (MT), Joe Manchin (WV), Mark Warner (VA), and Sinema.
But by what stretch of the imagination are Cassidy, Portman, Romney, Collins and Murkowski "moderate" or "centrist" Republicans? None of them are even close to the "center" of America's ideological spectrum. They all have opposed raising taxes on the wealthy, toughening environmental standards, expanding voting rights, adopting background checks for gun sales and limiting the sale of military-style assault weapons, and other measures that, according to polls, are overwhelmingly popular with the American public.
The five allegedly centrist Republicans voted with Trump between 65% and 89% of the time. (Collins, 65%, Murkowski, 65%, Romney, 75%, Portman, 88%, Cassidy, 89%). The five so-called centrist Democrats, in contrast, only voted with Trump between 30% and 50% of the time (Shaheen and Tester, 30%, Warner, 35%, and Manchin and Sinema, 50%). McConnell sided with Trump on 91% of key votes, while Majority Leader Charles Schumer (D-NY) did so only 23% of the time. Ideologically, the Democrats and Republicans live on different planets.
The idea that there are some "moderate" and "centrist" Republicans in Congress reinforces the myth that there is a group of Republicans who would work with Democrats to pass bipartisan legislation if both sides were only willing to compromise and be more pragmatic.
There is no overlap between the parties — this is not always true of the voters, but it is true of the elected officials. Political scientists describe this as 'asymmetrical polarization.' "
In truth, it is likely that the vote on the bipartisan infrastructure bill — designed to rebuild the nation's deteriorating roads and bridges and fund new broadband and climate resilience programs — will be the only time that some Republicans will join forces with Democrats to pass major legislation. Polls showed that the bill was extremely popular among Republican voters. They didn't want to have to run for re-election next year having opposed legislation that would create jobs and repair dangerous roads and bridges.
But don't expect any Republicans — especially McConnell — to support Biden's $3.5 trillion budget plan that would strengthen the social safety net, expand health care, provide free preschool and community college, extend a tax credit for child care, mandate that employers provide family leave, and implement new climate change programs. Ditto with Biden's other priorities, including legislation to strengthen voting rights, expand workers' rights (the Protect the Right to Organize Act), and provide undocumented immigrants with a path to citizenship.
Neither political party is ideologically monolithic. The Republicans are divided between conservatives (like Senators Romney, Collins, and Murkowski) and reactionaries (such as Senators Tom Cotton, Ted Cruz, Josh Hawley, and Marsha Blackburn and the 44-member House Freedom Caucus).
Democrats exist along a spectrum as well, spanning from liberals like President Biden, Speaker Nancy Pelosi, and Schumer to the most progressive members like Senators Jeff Merkley (D-OR), Elizabeth Warren and Ed Markey (D-MA), and Bernie Sanders (I-VT). There are a handful of moderate Democrats — like Senators Sinema and Manchin and House members Conor Lamb (D-PA), Carolyn Bourdeaux (D-NC), Elissa Slotkin (D-MI), and Abigail Spanberger (D-VA), but they are all considerably to the left of any Republican in Congress.
There is no overlap between the parties — this is not always true of the voters, but it is true of the elected officials.
Political scientists describe this as "asymmetrical polarization." For example, in their book, Polarized America, Nolan McCarty, Keith Poole, and Howard Rosenthal reveal that in the past few decades, Republicans have moved far to the right, while Democrats have moved slightly to the left. That suggests that, today, Republicans would have to compromise more than the Democrats to reach an agreement and they've demonstrated no desire to do so. Recall McConnell's statement in May that he was "100 percent" focused "on stopping" President Joe Biden's administration from being successful.
Once upon a time the Republican Party was more ideologically diverse. In the early 1900s, there were even progressive Republicans like Theodore Roosevelt (New York governor and later U.S. president), Hiram Johnson (California governor and U.S. senator), and Robert La Follette (Wisconsin governor and U.S. senator) and, during the Depression, New York City Mayor Fiorello La Guardia. They favored workers rights, sought to put limits on corporate irresponsibility, supported consumer protection laws, and sought to give women the right to vote, among other causes.
By the 1950s and 1960s, amid the Cold War and Red Scare, the bold progressive wing of the Republican Party had disappeared, but the GOP still had a liberal wing, including Senators Jacob Javits (NY), Charles Percy (IL), Margaret Chase Smith (ME), and Clifford Case (NJ), Governors and Senators Caleb Boggs (DE), Mark Hatfield (OR), George Aiken (VT), Lowell Weicker (CT), and John Chafee (RI), Governors Nelson Rockefeller of New York and George Romney of Michigan, and congressman and later New York City Mayor John Lindsay. That made it possible for Democrats and Republicans to find common ground.
Republican liberals were concentrated in the Northeastern states, but they eventually went the way of the manual typewriter and fountain pens. What remained was a small group of moderate Republicans like Senators Warren Rudman of New Hampshire, Nancy Kassebaum of Kansas, Arlen Spector of Pennsylvania, and John Warner of Virginia.
But by 2008, the Tea Party faction had taken over the Republican Party in those and many other states. That trajectory went even further once Donald Trump announced his run for president in 2015. By the time he entered the White House, the GOP's central tenet was loyalty to Trump. The moderates were evicted from the party. Even the handful of Republican members of Congress who occasionally disagreed with Trump — such as Reps. Paul Mitchell of Michigan, Adam Kinzinger of Illinois, and Liz Cheney of Wisconsin, and Senators Romney, Collins, and Murkowski — are hardline conservatives. The only moderate Republicans of any stature today are governors — Charlie Baker of Massachusetts, Phil Scott of Vermont, and Larry Hogan of Maryland— and they are outcasts within the national party.
The Republican Party's dramatic shift to the right began with Barry Goldwater's failed president campaign in 1964. His backers eventually rallied behind Ronald Reagan's successful presidential campaign in 1980. The rightward swing took a giant leap when Newt Gingrich became House Speaker in 1995, accelerated when the Tea Party emerged after Barack Obama was elected president in 2008, and went on steroids after Trump took office in 2017 and encouraged the white supremacist wing of the party.
Fueling the takeover of the GOP by the reactionaries was the growing political sophistication of the religious right (white Christian fundamentalists, who gave Trump 81% of their vote and accounted for almost half of his total vote in 2016), the rightward turn and growing militance of the National Rifle Association, the emergence of major right-wing funders like the Koch Brothers and Robert and Rebekah Mercer, political operatives like Jim DeMint, Grover Norquist, and Steve Bannon, and the right-wing echo chamber dominated by Fox News and Rush Limbaugh.
To consolidate the extremists' control of the party, they've used gerrymandering and restricted ballot accesswhile using dog whistle slogans about immigrants, and, this year, COVID-19 vaccines, and the Big Lie that the 2020 election was stolen to mobilize resentments and increase turnout among Republican votes.
In this context, the idea that Biden can build on the success of his infrastructure plan to corral more Republicans to join him in a revival of bipartisanship is foolish. The only way that Americans will see progress on the issues they care about is if the handful of moderates in the Democratic Party — particularly Sinema and Manchin — are willing to vote with their fellow Democrats rather than pretend that even a single Senate Republican will put country before party or re-election.
Peter Dreier is professor of politics at Occidental College and author of "The 100 Greatest Americans of the 20th Century: A Social Justice Hall of Fame."
Latest Cafe
Radicalization Pipelines: How Targeted Ads On Social Media Drive People To Extremes
By Jeanna Matthews
This article is part of TPM Cafe, TPM's home for opinion and news analysis. It first appeared at The Conversation. Have you…
Ahmaud Arbery's Murder Showed 'Southern Hospitality' Doesn't Always Apply To Black People
By Barbara Harris Combs
This article is part of TPM Cafe, TPM's home for opinion and news analysis. It first appeared at The Conversation. The idea…
A 21st-Century Reinvention Of The Electric Grid Is Crucial For Solving The Climate Change Crisis
By Charles F. Kutscher and Jeffrey Logan
This article is part of TPM Cafe, TPM's home for opinion and news analysis. It first appeared at The Conversation. In the…


Written by jerome, January 29th, My wife is 5ft two, 65 years old, great firm petite body and looks as if she is She dropped me in front of the airport and headed home. Sometime later I began a relationship with Christine and between the two of us we had 6 children. The oldest child was 8 and youngest almost 10 months old.


While dough is rising, melt 3/4 cup butter in a small saucepan over medium heat. Stir in 3/4 cup brown sugar, whisking until smooth. Pour into greased 9×13 inch baking pan. Sprinkle bottom of pan with 1/2 cup pecans; set aside. Melt remaining butter; set aside. Combine remaining 3/4 cup brown sugar, 1/2 cup pecans, and cinnamon; set aside.
Turn dough out onto a lightly floured surface, roll into an 18×14 inch rectangle. Brush with 2 tablespoons melted butter, leaving 1/2 inch border uncovered; sprinkle with brown sugar cinnamon mixture. Starting at long side, tightly roll up, pinching seam to seal. Brush with remaining 2 tablespoons butter. With serrated knife, cut into 15 pieces; place cut side down, in prepared pan. Cover and let rise for 1 hour or until doubled in volume. Meanwhile, preheat oven to 375 degrees F (190 degrees C).


Bill Sheridan is stand ing, back against the wall, fittingly, inside the Timex Underperformance Center, and on this day, it is my duty to ask the questions many disgruntled Giants fans want answered.
The Giants' defensive coordinator stands in the line of fire, and in the line of ire, and over the last month and a half, Bill Sheridan has no defense.
If Sheridan wasn't a good football man, Tom Coughlin never would have promoted him. But a good football man hasn't been enough to do the great job that has been required once Kenny Phillips started the injury dominoes to fall. Around these parts, where men like Sam Huff, Lawrence Taylor and Harry Carson are woven deep into the fabric of the franchise, playing dumb, playing soft, these are indefensible crimes.
And now, with the season teetering precariously, with Antonio Pierce gone, here come Tony Romo and the hated Cowboys. And who among the angry mob will not shudder when Sheridan tries to draw a line in the sand and dares America's Team to cross it?
"I don't understand how people can put so much pressure on one guy," good soldier Justin Tuck said. "Regardless of what plays are called, or anything of that nature, it's up to the players to execute.
Sheridan said, "We're just not consistently physical" — but he expects them to be physical this time.
He does not worry about harnessing the kind of emotion that could result in a lack of discipline in the eyes of the zebras.
Maybe some of them want him coming out of his skin as well.


text:
New Partytype

        <form class="form-horizontal" data-ng-submit="create()" novalidate>
            <fieldset>

                Utsträckning

                   <select data-ng-options="o.name for o in options" data-ng-model="selectedOption">
                        </select>

                Område

                    <input type="text" data-ng-model="location" id="location" class="form-control" placeholder="Ex: Sverige, västernorrland, Sundsvall..." required>

                <input type="submit" class="btn btn-primary">

       </fieldset>
   </form>


Occupy Oakland protesters carrying the General Strike banner march through downtown. Mastered in Apple Pro Res 422 HQ and Uncompressed, available in all forms of HD and SD.
Occupy Oakland protesters carrying the General Strike banner march through downtown. They chant "We are the 99 percent." Mastered in Apple Pro Res 422 HQ and Uncompressed, available in all forms of HD and SD.
Occupy Oakland protesters carrying signs gather downtown on the day of the General Strike. Mastered in Apple Pro Res 422 HQ and Uncompressed, available in all forms of HD and SD.


text:
Joachim von Siegroth und Schlawikau (* 25. Dezember 1896 in Oberlobendau, Niederschlesien; † 2. Mai 1945 bei Halbe) war ein deutscher Generalmajor der Wehrmacht.

Leben
Siegroth besuchte von 1903 bis 1907 das Adelige Stift in Breslau und wurde ab 1907 in der Kadettenanstalt in Wahlstatt erzogen. Ostern 1913 wurde er an die Hauptkadettenanstalt Lichterfelde in Berlin versetzt, wo er im August 1914 als Portepée-Fähnrich ausschied. Am 11. August 1914 trat er als Fahnenjunker in die Preußische Armee ein. Mit dem Füsilier-Regiment "Graf Roon" (Ostpreußisches) Nr. 33 nahm er ab August 1914 am Ersten Weltkrieg teil. In der Schlacht von Tannenberg erlitt er eine schwere Beinverwundung durch Granatsplitter. 1915 wurde er zum Leutnant befördert und ein zweites Mal verwundet. Im selben Jahr fiel auch sein Bruder. Ab Juni 1918 bis zum Kriegsende fand er an der Westfront Verwendung. Ausgezeichnet mit dem Eisernen Kreuz II. Klasse, dem Hanseatenkreuz sowie dem Verwundetenabzeichen  in Schwarz war er nach Kriegsende zunächst beim Grenzschutz in Sankt Annaberg/Oberschlesien tätig, bevor Siegroth im Zuge der Heeresverringerung den Militärdienst verließ und 1919 zur Polizei ging. Dort erfolgte 1926 die Beförderung zum Polizei-Hauptmann und 1933 zum Polizei-Major als Leiter der Höheren Polizeischule Potsdam-Eiche.

Am 1. Oktober 1935 wurde er als Major in das Heer der Wehrmacht übernommen, wo er zum traditionsreichen Infanterie-Regiment 9 der 23. Infanterie-Division kam. Am Neujahrstag 1938 wurde er Taktiklehrer an der Kriegsschule Dresden. Bei der Mobilmachung für den Zweiten Weltkrieg war er zunächst an der Infanterieschule Döberitz, bevor er am 26. Januar 1939 Bataillonskommandeur im Infanterie-Regiment 122 am Westwall wurde.

In der zweiten Phase des Westfeldzuges führte er das I. Bataillon des Infanterie-Regiments 122 u. a. in den schweren Kämpfen am Chemin des Dames. Anfang Oktober 1940 wurde er Regimentskommandeur des neuen Infanterie/Grenadier-Regiments 255, das er im Juni 1941 im Verband der 110. Infanterie-Division im Deutsch-Sowjetischen Krieg beim Angriff auf Mittelrussland führte. Das Regiment kämpfte bis Ende 1941 bei Wilna, Smolensk, Wjasma, Klin und Rshew. Am 19. Dezember 1941 erhielt Siegroth das Deutsche Kreuz in Gold.

Am 1. Februar 1942 wurde er zum Oberst befördert und blieb weiterhin Regimentskommandeur, welches das gesamte Jahr 1942 über bei der 9. Armee im Raum Rshew eingesetzt war. Ab April 1943 stand die 110. Infanterie-Division bei Brjansk im Einsatz und am 15. November 1943 erhielt von Siegroth als Oberst und Kommandeur des Grenadier-Regiments 255 die Ehrenblattspange für seine hervorragenden Leistungen bei den Kämpfen im Gebiet Kurbaki. Im Frühjahr 1944 war er auf dem 10. Divisionsführerlehrgang in Hirschberg und wurde anschließend am 1. Juli 1944 Kommandeur der Fahnenjunkerschule VI in Metz. Mit einer Kampfgruppe der Schule bewährte er sich im Kampf um Metz, insbesondere bei der Verteidigung der Feste Kronprinz. Dafür erhielt er am 18. Oktober 1944 das Ritterkreuz des Eisernen Kreuzes. Zur Erinnerung an den erfolgreichen Einsatz der nach ihm benannten Kampfgruppe wurde am 24. Oktober 1944 auf seine Anregung das Ärmelband Metz 1944 gestiftet, für das er die Verleihungsbefugnis hatte.

Seit dem 1. Februar 1945 war er Kommandeur der 712. Infanterie-Division an der Oder bei Küstrin und führte diese in der Schlacht um die Seelower Höhen. Nachdem er am 19. April 1945 durch General der Infanterie Theodor Busse zum Eichenlaub vorgeschlagen worden war, wurde er sechs Tage vor der Kapitulation der Wehrmacht mit seiner Division im Kessel von Halbe eingeschlossen und ist dort vermutlich beim Ausbruchsversuch gefallen. Die genauen Umstände sind bis heute unbekannt.

Siehe auch
 Siegroth (Adelsgeschlecht)

Weblinks

Einzelnachweise

Leutnant (Preußen)
Person im Ersten Weltkrieg (Deutsches Reich)
Polizist (Deutsches Reich)
Generalmajor (Heer der Wehrmacht)
Infanterist (Deutsches Reich)
Person im Zweiten Weltkrieg (Deutsches Reich)
Träger des Deutschen Kreuzes in Gold
Träger des Ritterkreuzes des Eisernen Kreuzes
Träger des Hanseatenkreuzes (Verleihungsstadt unbekannt)
Träger des Schlesischen Bewährungsabzeichens
Deutscher
Geboren 1896
Gestorben 1945
Mann


text:
HDAC10 Is Positively Associated With PD-L1 Expression and Poor Prognosis in Patients With NSCLC
Ning Wei
Wei, N. (2020). HDAC10 Is Positively Associated With PD-L1 Expression and Poor Prognosis in Patients With NSCLC. Frontiers in Oncology.
HDAC10 Is Positively Associated With PD-L1 Expression and Poor Prognosis in Patients With NSCLC. / Wei, Ning.
In: Frontiers in Oncology, 2020.
Wei, N 2020, 'HDAC10 Is Positively Associated With PD-L1 Expression and Poor Prognosis in Patients With NSCLC', Frontiers in Oncology.
Wei N. HDAC10 Is Positively Associated With PD-L1 Expression and Poor Prognosis in Patients With NSCLC. Frontiers in Oncology. 2020.
Wei, Ning. / HDAC10 Is Positively Associated With PD-L1 Expression and Poor Prognosis in Patients With NSCLC. In: Frontiers in Oncology. 2020.
@article{8a01da567b8442288dda69f70ea35412,
title = "HDAC10 Is Positively Associated With PD-L1 Expression and Poor Prognosis in Patients With NSCLC",
author = "Ning Wei",
publisher = "Frontiers Media S. A.",
T1 - HDAC10 Is Positively Associated With PD-L1 Expression and Poor Prognosis in Patients With NSCLC
AU - Wei, Ning


Hey Friends. I'm gonna talk a bit about the Allen fam today. Some of you may have noticed that I'm not posting as frequently as I was a few months ago. There's a good reason for that: our youngest Gus has been taking up a lot of my days. We've been taking trips to the zoo, visiting the library, going to IKEA for fun, running errands together, you name it. Now that his older brother is at kindergarten every day it has been nice having some one-on-one time together, and we've had a blast. I've been so happy to have this time with him and I'm glad to see him learning and growing every day.
Around Gus' 3rd birthday we noticed that his language skills were not quite where most 3-year olds typically are, this fall we sought out the developmental specialists at the Minneapolis school district. After many meetings and evaluations with Gus, they informed us that that Gus is on the Autism Spectrum.
It was a shock and a surprise, and then it also wasn't. Like I said, his language skills have been slow to fill in (although they are always improving). He has a hard time in social situations with people he doesn't know; he's super shy and covers his face when introduced to new situations. Also, he is kind of obsessed with trains. He loves talking about trains, playing with toy trains, reading books about trains, wearing PJs with trains on them, you name it. Having hyper-focused interests is a common thread with autism.
He is also incredibly loving, affectionate, kind, sweet, snuggly, funny (very funny) and smart. He loves his brother Finn and idolizes him. He loves to wrestle his dad, demanding nightly roughhousing sessions before bed. And he's got that having your mom wrapped around your little finger thing figured out. After spending time with people he warms up to them very well. You know you've broken the seal with Gus when he starts tickling you – that's his way of showing you that he's interested in being your friend.
As a family we are slowly trying to figure out what this diagnosis means for us. We are very positive about having a plan for Gus. He is starting preschool (today!) specifically designed for young kids on the Autism Spectrum, and the goal is to have him ready to enter Kindergarten in a few short years. Gus is three and a half, so he has a lot of time to figure out strategies to help him with his communication and socialization by the time kindergarten comes around.
We are taking it day by day, but are nothing short of positive. We will continue on doing the things we always do. We will try our hardest not treat him any differently than his brother or other kids. We will work on honing his new skills as he learns them. This might be the last time I ever mention this for all I know. WE don't want to label him as "broken," because he's not. He just learns and interacts differently, as do millions of people around the world who are on the Autism Spectrum. So we will celebrate him and his uniqueness as a family!
So why am I telling you guys? Well, I have a lot of friends and family that check up on us via the blog and I figured this was a more personal way of sharing the news than writing a dumb and awkward Facebook post. It's also kind of a tricky subject to just drop on folks in casual conversation, and I don't want people finding out via the old rumor mill either. We are not hiding anything, and I don't want it to seem that way, but like I said it's kind of difficult to bring up in regular conversation too. This blog is as much about making our house a home as it is about our personal life.
I'd also be happy to hear from any of you who might have experienced something similar with your family. We are very positive, and sharing lifts us up and helps us learn more.
I had some experience with this when I was a nanny. The family knew something was "different" with their son but they started a specialized program around 3 1/2 and he THRIVED! He's now 7 and a fantastic dude!
Every kid has different needs ~ different ways of learning ~ different ways of developing.
I always liked the show "Parenthood" [NBC] for how they interacted with their son.
Thanks for the comment Abby, it really means a lot to us to hear of other peoples experiences. We are confident that Gus will thrive too.
Amoung my many jobs (like upholstery) I was also a nanny for years. The last family I worked with for three years the mom is the lead psychologist with MEAP (Minneapolis Early Autism Project). Check them out if you need any more resources (http://www.meapkids.org). She's awesome and there are so many resources if you need them. Sounds like you guys are doing great-keep on being awesome!
Hey Laura! Where've you been? I was just looking at my blue sofa the other day and thought of you – you really helped me though that.
Thanks for the link, I will def check it out, although I'm processing things very carefully and slowly right now.
Take the time you need-you got this.
You are so cool!!!!! I love that you are doing that. I can't wait for you to help me with my electrical stuff!
I worked at a major autism clinic for a few years and I picked up a bit of knowledge on the topic. One of the main things that I learned (actually proven in studies) is that the earlier someone on the spectrum starts to receive specialized assistance, the better their outcomes (emotionally, socially, educationally, etc.). It sounds like you're doing all the right things.
Hey Ali, Thanks for taking the time to comment. I've also heard this, and am hopeful Gus will pick up new tools to help him as he attends school. Thanks again!
Hey Lizzie, Thank you for taking the time to leave a comment. Thanks for your advice, I hope Gus realizes that he's not alone, I'm confident that will probably happen. As with all kids, social interactions will be an experience as he grows, and I just hope to be present and capable of helping him with whatever hurtles he runs into along the way. Thanks again!
Allison thanks for sharing! I am in the early childhood field and have been teaching kids Gus age for 7 years! I'm so happy he is getting started with school and how on board his family is–its so amazing what early intervention can do in a little ones life.
Hey Carrie! Thanks for your comment. I was terrified about him starting school today, he just seems so little and vulnerable to me, especially with is shyness. Now that we've taken the first step, and had our first day at school, I'm feeling very excited for things to come. I think there will be a lot of good improvements and gains happening in his future.
I'm on the spectrum as are many of my friends (none of us diagnosed as children, met all of them under other various circumstances unrelated to autism). I think part of the reason for no diagnoses is partially age (people less frequently diagnosed unless they were having pretty severe problems) and partially that we grew up in families where "neurotypical" wasn't the norm so we had other quirky people (including but not limited to others with autism) around us and raising us.
I really wish the DSM hadn't removed Aspergers as a separate diagnosis–I've had people tell me I'm not autistic because their experiences are with people for whom it IS a disability (and I also feel like I'm co-opting the language of people/families who are actually facing significant hurdles). It's not a disability for me or my friends. It's just a small cluster of traits, like being extroverted. The actual basis of mine is very different from what the societal perception is (which is one reason I am more anonymous here): I personally fell in the early-language-acquisiton group (but I'm also an oldest girl-child), extroverted (albeit shy and awkward), no problems with eye contact. I definitely express the very strong interests, along with a particular kind of need for structure/logic.
For social situations, I think my parents did a really good job. They made it very clear that there were different contexts and that dressing/behaving/speaking differently in these was expected, but within this they tried to empower. Dressing up meant choosing from appropriate options (not being told exactly what to wear). When talking to strangers, they were patient in playing out potential scenarios, acceptable responses, the minimal level of engagement required, socially appropriate scripts, what conversation might look like, etc. We regularly were in short-duration (as little as half an hour) social situations with people of varying ages and backgrounds.
Lastly, I would be really uncomfortable with my parents announcing my autism or any other private issues publicly, even to friends. My parents did share publicly (in conversation with friends) about a medical procedure I had as a kid after an accident and I was mortified at the time but unable to name/express it for decades, despite not being a particularly private person. I think even as an adult, I would feel extremely uncomfortable if they shared about my autism on Facebook or with their friends–I'm not at all ashamed, but I prefer to control when and where I share that kind of information.
I'd be happy to email with you if you have any questions!
Hey J. Thanks for your comment, it's good to hear your point of view. Similar to what your parents have done, I too notice that I prepare Gus for scenarios he might encounter and give him little bits of language he might need. Because he's little, we tell him to just say "no thank you" rather than covering his face and aggressivly saying "NO!" when another adult might ask him a questions. That seems to help diffuse his anxieties and draw the attention away from him.
Getting help early on is the key. What a wonderful mom you are!
Thanks Jill, I think we're on the right path!
Thanks so much for sharing. I just want to encourage you and tell you you're in good hands! My son was diagnosed by MPS when he was just 19 months. He is in first grade now having been in the city's Autism program since he was in diapers. Each year I've been blown away by how amazing his team is. They are unbelievably patient and so knowledgeable. Our dev. pedi and psychiatrist also agree that MPS is one of the best around. And Gus is such a lucky kid to have a big brother to emulate! I'm also available to email if you have questions!
Hey Renae, Thanks for taking a second to comment. This is so good to hear! We have acquaintances that have worked in the MPS Special Ed department and ECFE, and we've heard great things as well. I'm really feeling encouraged about what is to come. I might take you up on that e-mail, FYI. I'd be curious to hear more about what steps you and your family took – it sounds like you have quite the team behind you. Thanks for reaching out!
The kid has good parents. With you in his corner he will fine.
My now 13 year old son was diagnosed with a brain tumor that required many operations and 29 weeks of chemo to get under control. He is in remission now, but we remain thankful for both his current health and the experience. There is nothing like a crisis to point out how very truly caring and helpful your circle of friends, family and acquaintances are. Don't hesitate to ask for help when you need it, and know that your unique challenges may inspire others you don't even know and will help you remember that there are people out there who are in your shoes. We have really grown as a family because of my son's illness, and are so mindful, everyday, of just how deeply we value the simple joy in our lives.
Hey Lolly, Thanks so much for taking the time to leave a comment, I really appreciate it. Let me start by saying I am so happy to hear that your son is doing well! That's an incredible blessing. You've been given the gift of perspective. Throughout this experience I continually remind myself often that my family is happy, healthy and we have each other. I'm thankful for that.
Thank you for taking the time to empathize. There have been a lot of sleepless nights lately and I yearn to know normalcy. Gus is little right now and there are so many questions, I know that as he grows he will prove to me that it's all going to be okay. Thank you!
Hey MC, thanks for your comment. Its so good to hear about other peoples experiences, I'm really happy to hear that your nephew is doing so well! I've heard a lot of positive experiences with early intervention today which is very encouraging!
(hugs) to you and CHOOCHOO! to Gus!
My nephew had some delays when we was younger (and loved trains and Legos!) he is now an amazing, bright 11 year old. Seriously, the kid could do my job.
Beks! Thanks for the comment, it's so incredibly encouraging to hear things like this. It really means a lot to my husband and I, we really appreciate it.
Hello, I think I found your blog via Apartment Therapy. Anyway, I'm a fan. My older son is also on the spectrum. Early intervention has made such an impact. Our public school system is amazing. He was able to receive OT and Speech Therapy through the system before he entered kindergarten. Through our pediatrician we were also able to do addition speech and OT interventions with our local rehabilitation hospital. He is now in 5th grade! He is also a cuddle-r. Loves people, and is very affectionate. We found that Raising a Sensory Smart Child and The Out of Sync Child were really helpful when he was little (and still helps, now and again). Hang in there.
Hey Lauralou, Thank you for sharing with me! It is so good and encouraging to hear stories of what early intervention has done for other kids. Gus too will be doing OT and Speech Therapy, and I'm really looking forward to seeing how he responds to it. I am throwing both of those books into my Amazon shopping cart as we speak/type. Thanks so much for the recommendation. We are being very cautious of how we are getting information on the internets and what have yous, so we really appreciate suggestions from other people who have been there, done that.
I haven't commented in a while, but I still read and just wanted to say hi and let you know you have my support. Wishing you and your family all the best!
Thanks so much Janelle! Can't tell you how much we appreciate all the support, it means a lot to us and this week has been so much easier to take on because of it.
Telling others what's going on is something I've been struggling with since our son received his diagnosis about 18 months ago. This was beautifully written. Thank you for sharing. I understand completely how you feel, and to echo what everyone else just said, he will be fine because you are an awesome mom who is getting him what he needs. (I've never commented before, but I enjoy your blog).
Hey Jessica, Thanks so much for your comment. Really, thank you for sharing with me, it means so much to know that you (we, me) are not alone in this. I hope you and your fam are doing well.
I love your blog and have been a weekly fan for a couple of years now. Your post on your son really resonated with me for many reasons. My husband was diagnosed with Asperger's as an adult. We were engaged and had just bought a house and moved in together. I started noticing little things about his personality and those things grew and grew until I started doing research and read about Aspberger's Syndrome and new he had it. He was very open about it and agreed and we started seeing a therapist that specializes with people who are on the autism spectrum. We have seen her for over 4 years now and she has helped us in so many ways. My husband is a brilliant, loving, funny, kind man with many eccentricities that I wouldn't change for the world. I am proud to have him be my partner in life and let's face it- we all have our weirdness and our quirks. He is just a person that I get to live with and be a part of his world everyday. He has taught me to be a better, patient person that has a wonderful opportunity to see the world not only my way but his way as well. I can honestly say that his world is often way easier. I wouldn't want him any other way.
Also, my Aunt's name was Cecilia – such a good name!
2 very good friends of ours work at Lionsgate Academy in Crystal, one as a teacher, the other as a para. All of the kids in the school are on the autism spectrum. They love the kids and their work, and through talking to them, I have really come to believe that school is a amazing resource for Twin Cities families who need a place for their kid to be understood and to belong. Of course its impossible to know at this point whether it would be anything helpful for your son, but I just wanted to mention that it is out there since I hear about it a lot and think it sounds great. I hope you are well! I am thinking strongly of starting my own seedlings this year, so I'm now going to head over and catch up on your recent posts!
As you enter this adventure with Gus remember its OK to feel whatever you feel. Ask questions. Find people that truly understand you, your feelings, your son. Remember that your husband will process all of this quite differently than you will. And that's OK too. Keep living and doing and loving your family like you do!
Thank you so much for your vulnerability here. I really love your blog!
Bravo to you guys for getting him the help he needs and posting this on your blog. What a positive thing. I love your blog anyways, but I found another key way to relate to your blog since we both have kids on the spectrum. We just went through the process of getting our 2.5 year old dd diagnosed — so I understand a bit of what it's like to go through that, though everyone has their own experience. I like how you introduced it on your blog. We still haven't told everyone in our life yet – she was literally just diagnosed beginning of March – we're figuring that out still. Like you said, it's nothing we're trying to hide and we don't want to have people find out via the rumormill. So anyways, just wanted to say thanks for making this post. It helps normalize our experience and further understand we're never truly alone in the things we're going through.
Hey, Shannon. I know the diagnosis can be kind of shocking. I have to let you know that our Gus has grown so much in the last 8 weeks since starting preschool. There are still things he struggles with like bath time, toileting, and his language can be hard to understand at times, but he is growing by leaps and bounds. It's really reassuring to us. I imagine that your daughter will be starting some sort of preschool soon if she hasn't already – I know that it's scary but you will see her grow and learn as soon as she starts. Glad you took the time to say hey, I'll be thinking of you and your fam.
Thanks for the book recommendations. I will check all of these out for sure!


We have finally gotten a chance to get to this item on our list, screenshots of PDF files.
This feature will load the first page of any PDF file and then capture a screenshot of that page. Then, it will become available just like any other screenshot image.
This will happen automatically and does not require any coding changes. We have also decided to offer this feature as a value-add to all service levels (i.e. not a PRO feature upgrade).
We hope that our users will enjoy this additional functionality, at no charge, as a thank you for supporting our growing web page screenshot niche.
I'm trying to use this with the wordpress plugin, but when I use the short code with the pdf link it only generates a screen capture of the domain it is hosted on, rather than the document, and the image is not clickable as a link.
My first thought is that you are not using (and have not upgraded to) the "Inside Pages" PRO feature. Since any PDF would be a full URL (not just the base domain), this is a requirement.
Oh ok, when I read "ie. not a PRO feature upgrade" and I thought it was available to all users as a standard because it said 'all service levels' and 'at no charge'(I'm using a free account). That's what confused me.
So to use this feature I would have to purchase the "inside pages" PRO Feature? Makes sense.
Yeah, Duane also pointed that out, after you made your post. Bit of an oversight there.
Cannot screenshot full paths without "Inside Page", so I had not considered that when I wrote the announcement. Apologies for the confusion.
Update: As of 03/18/2016, there has been a change to the way that PDFs are handled as far as size and dimensions are concerned. These PDF captures are special in that they are now treated like "Custom Size" and "Full-Length" to allow for a greater variety of custom outputs.
So, if you have upgraded to either the "Custom Size" or "Full-Length" PRO features, you will be able to enter any dimensions you want.
If you do not have either of those upgrades or do not specify their parameters, then the PDF will be captured in the default 4:3 aspect ratio, which means it will likely be cropped and not display the full length of the PDF page. This way, the resulting screenshot will fit into the expected width/height space as any other default sized screenshot.


Hey r/judaism, I'm a long time reader but first time poster.
What do people think is the required to income to comfortably live an Orthodox Jewish life in a North American city like Boston or Chicago?
My wife and I are trying to buy life insurance, and there are online insurance calculators that try to determine the amount of income your dependents would need if you died. But of course, none of these calculators take into account the cost of Jewish schools, synagogue membership, kosher food, etc.


Jul. 8, 2012 11:00 a.m.
Early morning transit users in Greater Victoria were left scrambling on the holiday Monday, July 2, when an error in scheduling left five B.C. Transit routes unfilled.
Transit spokesperson Meribeth Burton, said as soon as the error was discovered, it took about an hour to get drivers in place on the routes.


All women's v-necks (except Real Housewife small & medium UNISEX grey) are a slightly loose fitting women's tee & follow this 1st size chart. The tri-black runs a little slimmer in the body than our other colors so if you prefer a roomy fit you may want to size up.
All black & white crew neck tees (& small/medium Real Housewife unisex grey v-necks) are unisex for a loose fit. Our black & white tees also run a size larger than typical unisex shirts so if you have a size that you normally order in unisex, we suggest sizing down from that.