text:
Fak Pathway
the origin of cell and the developing course of cytobiology
The four methods have proved different levels of specificity The
Posted on September 30, 2020 by fakp8655
The four methods have proved different levels of specificity. The least specific was the indirect immunofluorescent assay, which showed a low titre in all sera. Comparison of the results of the other three methods indicates that two sera were positive for anti-TBEV IgG and one for anti-TBEV IgM. The goat with the IgM positive serum sample could have been a source of the infected milk. it has been GDC 941 concluded that serological results for goats by the different methods should be compared before final diagnosis because the specificity of methods in use can differ significantly. (C) 2009 Elsevier B.V. All
"Dopamine (DA) deafferentation of the dorsolateral striatum has been shown to prevent habit development, leaving instrumental behavior under action-outcome
control that is persistently sensitive to modification of the motivational value of the reward. The present experiment further explored the basis of this dysfunction by examining the ability of intrastriatal DA agonist injections (D1 SKF 38393 or D2/D3 Quinpirole) during overtraining of a signaled instrumental task to restore habit formation in rats subjected to bilateral 6-hydroxydopamine (6-OHDA) lesions of the nigrostriatal dopaminergic pathway. Overtraining was followed by a test of goal sensitivity by satiety-specific devaluation of the reward. The results confirmed I-BET-762 solubility dmso the impaired shift in performance from action to habit in control lesioned rats. However, lesioned rats repeatedly injected with quinpirole D2/D3 agonist showed an increase in non-rewarded instrumental responses (inter-trials periods) during overtraining, suggesting
the development of perseverative behavior. Following the procedure of devaluation, quinpirole D2/D3 agonist treatment, and to a lesser Glutamate dehydrogenase extent SKF 38393 D1 agonist, caused the persistence of sensitivity to reward devaluation, indicating clear goal-directed behavior despite extended training. This absence of restoration of habit formation by DA agonist treatment is discussed in the light of DA agonist effects in Parkinson patients. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved."
"Presence of the apolipoprotein E (APOE) epsilon 4 allele is linked to an increased risk to develop Alzheimer's dementia (AD). However, there are controversial data concerning the impact of the APOE genotype on cognitive functioning and brain activity in healthy subjects. We used event-related functional magnetic resonance imaging (fMRI) to investigate the effects of APOE genotype on spatial contextual memory encoding and retrieval success in healthy older adults. Eighteen subjects (eight APOE4 heterozygotes (epsilon 4+) and 10 non-carriers (epsilon 4-), mean age 60.0 +/- 5.0 years) were included in the present analysis.
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In addition, these results show that the role of medial BA10 in P
In addition, these results show that the role of medial BA10 in PM likely involves varying contributions from functionally specific subregions. Neuropsychopharmacology (2012) 38, 655-663; doi:10.1038/npp.2012.230; published online 12 December 2012″
"Dopamine plays an important
role in fear and anxiety modulating a cortical brake that the medial prefrontal cortex exerts on the anxiogenic output of the amygdala and have an important influence on the trafficking of impulses between the basolateral (BLA) and central nuclei (CeA) of amygdala. Dopamine afferents from the ventral tegmental area innervate preferentially the rostrolateral main and paracapsular intercalated islands as well as the lateral central nucleus Selleck INK1197 of amygdala activating non-overlapping populations of D1- and D2-dopamine receptors located in these structures. Behaviorally, the intra-amygdaloid infusion of D1 agonists and antagonists elicits anxiogenic and anxiolytic effects respectively on conditioned and non-conditioned models of fear/anxiety suggesting an anxiogenic role for D1 receptors in
www.selleckchem.com/products/Vorinostat-saha.html amygdala. The analysis of the effects of D2 agonists and antagonists suggest that depending of the nature of the threat the animal experiences in anxiety models either anxiogenic or anxiolytic effects are elicited. It is suggested that D1- and D2-dopamine receptors in the amygdala may have a differential role in the modulation of anxiety. The possibility is discussed that D1 receptors participate in danger recognition facilitating conditioned-unconditioned associations by the retrieval of the affective properties of the unconditioned stimuli, and in the control of impulse trafficking from cortical and BLA regions to BLA and CeA nuclei respectively whereas 02 receptors have a role in Phloretin setting up adaptive responses to cope with aversive environmental stimuli. (C) 2009 Elsevier Ltd.
"Recombinant adeno-associated viruses (rAAVs) hold enormous potential for human gene therapy. Despite the well-established safety and efficacy of rAAVs for in vivo gene transfer, there is still little information concerning the fate of vectors in blood following systemic delivery. We screened for serum proteins interacting with different AAV serotypes in humans, macaques, dogs, and mice. We report that serotypes rAAV-1, -5, and -6 but not serotypes rAAV-2, -7, -8, -9, and -10 interact in human sera with galectin 3 binding protein (hu-G3BP), a soluble scavenger receptor. Among the three serotypes, rAAV-6 has the most important capacities for binding to G3BP. rAAV-6 also bound G3BP in dog sera but not in macaque and mouse sera. In mice, rAAV-6 interacted with another protein of the innate immune system, C-reactive protein (CRP). Furthermore, interaction of hu-G3BP with rAAV-6 led to the formation of aggregates and hampered transduction when the two were codelivered into the mouse.
These findings
are consistent with gustatory information
are consistent with gustatory information ascending from tongue to cortex both ipsilaterally and contralaterally, and provide preliminary support for hemispheric gustatory specialization. (c) 2013 Elsevier Ltd. All rights reserved."
"Forgiveness has received widespread attention among psychologists from social, personality, clinical, developmental, and organizational perspectives alike. Despite great progress, the forgiveness literature has witnessed few attempts at empirical integration. Toward this end, we meta-analyze results from 175 studies and 26,006 participants to examine the correlates of interpersonal forgiveness (i.e., forgiveness of a single offender by a single victim). A tripartite forgiveness typology is proposed, encompassing victims' (a) cognitions. (b) affect. and (c) constraints following offense, with each consisting of situational and dispositional
learn more components. We tested hypotheses with respect ISRIB manufacturer to 22 distinct constructs, as correlates of forgiveness, that have been measured across different fields within psychology. We also evaluated key sample and study characteristics, including gender, age, time, and methodology as main effects and moderators. Results highlight the multifaceted nature of forgiveness. Variables with particularly notable effects include intent ((r) over bar = -.49), state empathy ((r) over bar = .51), apology ((r) over bar = .42), and state anger ((r) over bar = .41). Consistent with previous theory, situational constructs are shown to account for greater variance in forgiveness than victim dispositions, although within-category differences are considerable. Sample and study characteristics yielded negligible effects on forgiveness,
despite previous theorizing to the contrary: The effect of gender was nonsignificant ((r) over bar = .01), and the effect of age was negligible ((r) over bar = .06). Preliminary evidence suggests that methodology may exhibit some moderating effects. Scenario methodologies led to enhanced effects for cognitions; recall methodologies led to enhanced effects for affect."
"Influenza outbreaks are widespread in swine and avian populations. Disease control is jeopardized by the extreme antigenic variability of virus strains. Primary isolation of Influenza Dapagliflozin virus is performed using embryonated chicken eggs (ECE), but alternatives to ECE are badly needed. Although various cultured cells have been used for propagating Influenza A viruses, few types of cells can efficiently support virus replication. One of the most commonly cell lines used in order to isolate Influenza A virus, is represented by the Madin Darby Canine Kidney (MDCK) cell line, but cells derived from primary swine organs (kidney, testicle, lung and trachea) can also be employed. The aim of this study was the evaluation of NSK, MDCK, UMNSAH/DF1 cell lines suitability, compared to ECE for isolation and propagation of Avian and Swine virus subtypes.
6 (353) mm(3), P = 2; and 86 (828) mm(3) vs 85 9 (352) mm(3), P
6 (353) mm(3), P = .2; and 86 (828) mm(3) vs 85.9 (352) mm(3), P = .4 172 (766) mm(3) vs 0 (228) mm3, P = .06, respectively). In patients with all three AA characteristics, mean number and volume of BL was significantly greater compared with other patients. Specifically, this increase was due mainly to CL (IL 0 (117) mm(3) vs 0 (172) mm(3), P = .9; CL 564 (687) mm(3) vs 0 (133) mm(3), P
= .001). None of the technical details considered was correlated with either IL or CL.
Conclusion: BL are frequent after protected CAS and are correlated with AA characteristics, learn more thus underlining the role of catheterization maneuvers in determining embolic events. TEE may be useful in patient's selection for CAS. (J Vasc Surg 2009;49:80-5.)"
"Why does moderate exposure to a drug reward make natural rewards increasingly Vismodegib clinical trial attractive to organisms, whereas prolonged exposure to the same drug reward has the opposite effect? The paradox behind that question remains unsatisfactorily captured by current theories of addiction. The incentive-sensitisation theory
is viewed as a promising approach to this paradox, although it provides no mechanism to explain the decrease in interest of natural rewards as time exposure to a drug increases. To attempt to remedy this problem, I describe a model called the anticipatory dynamics model (ADM) that suggests a pivotal role of anticipation and attention in motivational interactions. Oxymatrine in addition to relying on strong neuropsychopharmacological data, the ADM provides an original conception of motivational specificity. The ADM is an extension of the incentive-sensitisation theory that hypothesizes how drugs interact with natural rewards. It has not been tested empirically, although a possible experiment to test two predictions in the field of addiction is presented. (c) 2008 Elsevier Ltd. All rights reserved."
"Background: The distal part of the internal carotid artery (ICA) close to the skull base can be reached surgically with different approaches. Exposure
using the standard lateral incision is eventually limited by bony structures which preclude the wide-angled operative field necessary for en bloc resection of tumors or primary vascular pathology that abuts the parapharyngeal space. In these unusual cases, use of a combined midline mandibulotomy and neck incision provides necessary operative exposure.
Aim: We report our experience using combined midline mandibulotomy and neck incision for exposure of high carotid lesions. We also discuss different surgical and endovascular approaches in light of the literature.
Patients and Methods. Five patients were operated on for high ICA lesions: 2 for malignant head and neck tumors, 1 for an extended paraganglioma, and 2 for large symptomatic ICA aneurysms.
In addition, the increase in synchronization between the left dor
In addition, the increase in synchronization between the left dorsal inferior frontal gyrus and superior parietal lobule in the dual task condition may induce effective communication between these brain regions and contribute to more attentional processing than in the single task condition, due to greater and more complex demands on voluntary attentional resources. (C) 2012 Elsevier
Ltd. All rights reserved."
"In buy Rapamycin recent years, influenza viruses with pandemic potential have been a major concern worldwide. One unresolved issue is how infection or vaccination with seasonal influenza virus strains influences the ability to mount a protective immune response to novel pandemic strains. In this study, we developed a mouse model of primary and secondary influenza infection by using a widely circulating seasonal H1N1 virus and the pandemic strain of H1N1 that emerged in
Mexico in 2009, and we evaluated several key issues. First, using overlapping peptide libraries encompassing the entire translated sequences of 5 major influenza virus proteins, we assessed the specificity of CD4 T cell reactivity PLX3397 solubility dmso toward epitopes conserved among H1N1 viruses or unique to the seasonal or pandemic strain by enzyme-linked immunospot (ELISpot) assays. Our data show that CD4 T cells reactive to both virus-specific and genetically conserved epitopes are elicited, allowing separate tracking of these responses. Populations of CYTH4 cross-reactive CD4 T cells generated from seasonal influenza infection were found to expand earlier after secondary
infection with the pandemic H1N1 virus than CD4 T cell populations specific for new epitopes. Coincident with this rapid CD4 T cell response was a potentiated neutralizing-antibody response to the pandemic strain and protection from the pathological effects of infection with the pandemic virus. This protection was not dependent on CD8 T cells. Together, our results indicate that exposure to seasonal vaccines and infection elicits CD4 T cells that promote the ability of the mammalian host to mount a protective immune response to pandemic strains of influenza virus."
"Quantitative proteomics based on MS is useful for pointing out the differences in some food proteomes relevant to human nutrition. Stable isotope label-free (SIF) techniques are suitable for comparing an unlimited number of samples by the use of relatively simple experimental work-flows. We have developed an internal standard label-free method based on the intensities of peptide precursor ions from MS/MS spectra, collected in data dependent runs, for the simultaneous qualitative characterization and relative quantification of storage proteins of Lupinus albus seeds in protein extracts of four lupin cultivars (cv Adam, Ares, Lucky, Multitalia).
(Funded by GEICAM and Sanofi-Aventis; ClinicalTrials gov number,
(Funded by GEICAM and Sanofi-Aventis; ClinicalTrials.gov number, NCT00121992.)
N Engl J Med 2010;363:2200-10."
"This study examined the associations among chronic health conditions, sociodemographic factors, and depressive symptomatology in older married couples. Data from the 2004 wave of the Health and Retirement Study (n = 2,184 couples) were analyzed. Results indicated a reciprocal relationship in depressive symptoms between spouses. Additionally, post hoc analyses indicated that husbands' stroke and high
blood pressure were related to increased depressive symptomatology among wives. Beyond the reciprocal relationship, husbands were unaffected by wives' health. These results suggest sex differences underlying psychological distress VX-765 supplier in the context of physical health among older adults and that older women with husbands who have high levels of depressive symptomatology. high blood pressure, or a history of stroke may be at particular risk of experiencing
depressive symptoms."
"Background: A high body-mass index (BMI, the weight in kilograms divided by the square of the height in meters) is associated with increased mortality from cardiovascular disease and certain cancers, but the precise relationship between BMI and all-cause mortality remains uncertain.
Methods: We used Cox regression to estimate hazard ratios and 95% confidence intervals for an association between BMI and all-cause mortality, adjusting for Temsirolimus manufacturer age, study, physical activity, CB-839 alcohol consumption, education, and marital status in pooled data from 19 prospective studies encompassing 1.46 million white adults, 19 to 84 years of age (median, 58).
Results: The median baseline BMI was 26.2. During a median follow-up period
of 10 years (range, 5 to 28), 160,087 deaths were identified. Among healthy participants who never smoked, there was a J-shaped relationship between BMI and all-cause mortality. With a BMI of 22.5 to 24.9 as the reference category, hazard ratios among women were 1.47 (95 percent confidence interval [CI], 1.33 to 1.62) for a BMI of 15.0 to 18.4; 1.14 (95% CI, 1.07 to 1.22) for a BMI of 18.5 to 19.9; 1.00 (95% CI, 0.96 to 1.04) for a BMI of 20.0 to 22.4; 1.13 (95% CI, 1.09 to 1.17) for a BMI of 25.0 to 29.9; 1.44 (95% CI, 1.38 to 1.50) for a BMI of 30.0 to 34.9; 1.88 (95% CI, 1.77 to 2.00) for a BMI of 35.0 to 39.9; and 2.51 (95% CI, 2.30 to 2.73) for a BMI of 40.0 to 49.9. In general, the hazard ratios for the men were similar. Hazard ratios for a BMI below 20.0 were attenuated with longer-term follow-up.
Conclusions: In white adults, overweight and obesity (and possibly underweight) are associated with increased all-cause mortality. All-cause mortality is generally lowest with a BMI of 20.0 to 24.9.
N Engl J Med 2010;363:2211-9.
Results We used minimum residual factor analysis (consensus anal
Results. We used minimum residual factor analysis (consensus analysis) to establish domain coherence and assess overall consensus concerning contents of the domains. We established subvariation within the overall consensus by comparing levels of observed versus predicted inter-informant
agreement. Results showed divergent patterns of inter-informant agreement between young and old participants across domains. Qualitative examination of items with higher salience for young versus old revealed age differences consistent with prior findings in each domain.
Discussion. The concatenation of these techniques renders freelisting an accessible, easily administered tool for probing age and group differences in cultural domains."
"Olprinone, an inhibitor of cyclic nucleotide phosphodiesterase III, inhibited an increase in intracellular Ca(2+) Selleck Entospletinib concentrations for acutely dissociated rat hippocampal pyramidal neurons induced by extracellular high K(+) (35 mM) depolarization. Olprinone (100 mu M) significantly reduced spontaneous glutamate release from
rat hippocampal slices. Furthermore, olprinone significantly decreased the rate of alpha-amino-3 hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor-mediated miniature YH25448 mouse excitatory postsynaptic currents (AMPA-mEPSCs) monitored from CA1 pyramidal neurons of rat hippocampal slices, and the effect was blocked by KT5823, an inhibitor of protein kinase G (PKG), but not by H-89, an inhibitor of protein kinase A (PKA). In the PKA assay using PC-12 cells, olprinone did not activate PKA. Taken together, the results of the present study show Cyclooxygenase (COX) that olprinone attenuates intracellular Ca(2+) rise through voltage-sensitive Ca(2+) channels and inhibits presynaptic glutamate release via a cGMP/PKG pathway. (C) 2008 Elsevier Ireland Ltd. All rights reserved."
"Objectives. Although it is well established that low socioeconomic status is related to mortality, little research has focused on whether financial strain predicts mortality. Still less research has examined this
question by race, despite the evidence that African Americans suffer earlier mortality and more financial strain at the same levels of socioeconomic status than their Caucasian counterparts. We examined the extent to which financial strain was associated with increased mortality risk in older women and whether the relationship differed by race.
Methods. The sample was the Women's Health and Aging Studies I and II of community-dwelling older women aged 70 to 79. We used Cox proportional hazards models to estimate the effect of financial strain on 5-year mortality rates.
Results. Women who reported financial strain were almost 60% more likely to die within 5 years independent of race, education, absolute income. health insurance status, and comorbidities (p < .001) than their counterpoints who did not, Although race was not a predictor of mortality.
Dimerization of E7 is attributed primarily to the C-terminal doma
Dimerization of E7 is attributed primarily to the C-terminal domain, referred to as conserved region 3 (CR3). CR3 is highly structured and is necessary for E7′s transformation ability. It is also required for binding of numerous E7 cellular targets. To systematically analyze the molecular mechanisms by which find more HPV16 E7 CR3 contributes to carcinogenesis, we created a comprehensive panel of mutations in residues predicted to be exposed on the surface of CR3. We analyzed our novel collection of mutants, as well as mutants targeting predicted hydrophobic core residues of the dimer, for the ability to dimerize. The same set of mutants was also assessed functionally for transformation capability in a baby
EPZ015938 rat kidney cell assay in conjugation with activated ras. We show that some mutants of HPV16 E7 CR3 failed to dimerize yet were still able to transform baby rat kidney cells. Our results identify several novel E7 mutants that abrogate transformation and also indicate that E7 does not need to exist as a stable dimer in order to transform cells."
density of introns is both an important feature of genome architecture and a highly variable trait across eukaryotes. This heterogeneity has posed an evolutionary puzzle for the last 30 years. Recent evidence is consistent with novel introns being the outcome of the error-prone repair of DNA double-stranded breaks (DSBs) via non-homologous end joining (NHEJ). Here we suggest that deletion of pre-existing introns could occur via the same pathway. We propose a novel framework in which species-specific differences in the activity of NHEJ and homologous recombination (HR) during the repair of DSBs underlie changes in intron density."
"Introduction: Patients with cardiovascular disease who stop smoking lower their risk of subsequent morbidity and mortality. However,
patients who have suffered a myocardial Vitamin B12 infarction (MI) are more likely to be depressed than the general population, which may make smoking cessation more difficult. Poor social support may also make smoking cessation more difficult for some patients. This study examines the effect of cognitive behavior therapy (CBT) for depression, low perceived social support or both on smoking behavior in post-MI patients. Methods: Participants were 1233 patients with a history of smoking enrolled in the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) trial who provided 7-day point-prevalence smoking behavior information at baseline and at two or more follow-up assessments. The ENRICHD trial enrolled post-Ml patients with depression, low perceived social support or both. Participants were randomly assigned to either CBT intervention or usual care. We used mixed effects models to accommodate data from multiple smoking point-prevalence measures for each individual participant.
These assays identified a number of amino acids that, when altere
These assays identified a number of amino acids that, when altered, abolish VP23 function. Abrogation of virus assembly by a single-amino-acid find more change bodes well for future development of small-molecule inhibitors of this process. In addition, a number of mutations which localized to a C-terminal region of VP23 (amino acids 205 to 241) were still able to interact with VP19C but were lethal for virus replication when introduced into the herpes simplex virus 1 (HSV-1) KOS genome. The phenotype of many of these mutant viruses was the accumulation of large open capsid shells. This is the first demonstration of capsid shell
accumulation in the presence of a lethal VP23 mutation. These data thus identify a new domain
of VP23 that is required for or regulates capsid shell Alpelisib clinical trial closure during virus assembly."
"The most current human-based studies in which brain-derived neurotrophic factor (BDNF) levels in the peripheral blood system are analyzed use it as an indicator that represents BDNF levels in the CNS. However, whether circulating BDNF (serum and plasma) is positively or inversely associated with cardiorespiratory fitness levels (VO2max) is still controversial, and no study has done to investigate exercise effects on the concentration of BDNF stored in circulating platelets which, in fact, store a large amount of circulating BDNF. Thus, the purpose of this study was to determine the relation between VO2max and all circulating BDNF levels (serum, plasma and platelets) in college male students (N = 18: age, 19 +/-
1 years; height, 173.22 +/- 7.65 cm; weight, 78.25 +/- 14.25 kg; body fat percent, 13.82 +/- 5.68%). Dual X-ray energy absorptiometry whole body scan was used to measure their Glycogen branching enzyme body composition. After the overnight fast, all participants were performed VO2max test, and their blood was collected at rest and immediately after the exercise. Our data resulted in significant increases in platelet counts and serum, plasma and platelet BDNF levels immediately after the exercise (p < 0.01). VO2max had a significant negative correlation with serum BDNF, plasma BDNF and platelet BDNF at rest (p < 0.05) but a significant positive correlation with serum, plasma BDNF, and platelet BDNF immediately after the exercise (p < 0.01). However, our data show no correlation between VO2max and platelet count both at rest and immediately after the exercise. In conclusion, this is the first study showing that basal BDNF levels are inversely correlated with cardiorespiratory fitness levels but that the inverse correlations turn into positive correlations with all circulating BDNF levels immediately after the exercise. Moreover, it is the first time to provide evidence that platelet BDNF levels are also positively affected by the exercise.
Pretreatment of NB4 cells with indomethacin significantly impaire
Pretreatment of NB4 cells with indomethacin significantly impaired ATRA/As(2)O(3)-induced differentiation, as assessed by cell morphology, nitroblue tetrazolium test or CD11c expression. PGE(2) reversed the negative effect of indomethacin on differentiation of ATRA/As(2)O(3)-treated NB4 cells. Y-27632 In conclusion, COX- 1 contributes to ATRA-dependent maturation of NB4 cells and is affected by As2O3. These results also suggest that nonsteroidal antiinflammatory drugs should be avoided in APL patients treated with the combination of ATRA and As(2)O(3)."
"Brain injury can often result in the subsequent appearance
of seizures, suggesting an alteration in neural excitability associated with the balance between neuronal excitation and inhibition. The process by which this occurs has yet to be fully elucidated. The specific nature of the changes in excitation and inhibition is still
unclear, as is the process by which the seizures appear following injury. In click here this study, we investigated the effects of focal cortical compression on electrically-induced localized seizure threshold in rats. Male Long Evans rats were implanted with stimulating screw electrodes in their motor cortices above the regions controlling forelimb movement. Initial seizure threshold was determined in the animals using a ramped electrical stimulation procedure prior to any compression. Following initial threshold determination, animals underwent sustained cortical compression and then following a 24 h recovery period stiripentol had their seizure thresholds tested again with electrical stimulation. Reliability of threshold measurements was confirmed through repeated measurements of seizure threshold. Localized seizure threshold was significantly lowered following sustained cortical compression as compared with control cases. Taken together, the results here suggest a change in global brain excitability following localized, focal compression. (C)
2008 IBRO. Published by Elsevier Ltd. All rights reserved."
"The 190 kD (p190) and 210 kD (p210) Bcr-Abl proteins are responsible for the pathophysiology of Philadelphia chromosome (Ph)(+) leukemia. We applied RNA interference (RNAi) to specific killing of p190(+) cells, and determined the optimal sequences for gene silencing in the BCR, junctional and ABL regions of p190, respectively. Then, p190(+) and p210(+) cells were infected with lentiviral vectors encoding these shRNAs, resulting in efficient killing of p190(+) cells, while p210(+) cells were only sensitive to shBCR and shABL. In p190-transformed Ba/F3 cells, silencing of p190 specifically inhibited tyrosine phospohorylation of Stat5 prior to their death, but did not affect phosphorylation of Jak2, Akt or MEK1/2. In contrast, downregulation of p190 by their treatment with 17-allylamino-17demetoxygeldanamycin (17-AAG) was associated with reduced protein levels of Jak2, Akt and MEK1/2.
thrombin-inhibitor
Blood samples were collected twice; before and after treatment P
6 days non-op) treatment (p = 0 007) At follow-up, higher
Fifty one patients diagnosed with MCI and fourtneen
64, 95% confidence interval 1 09 to 6 41, p == 0 032) Conclusion
Sulfur was translocated from roots and accumulated mainly in the


Aristotle said: "Being is everything he knows", so that where there is real knowledge - not its appearance or shadow - knowledge and being are one and the same thing.
All modern knowledge is based on logic. With a few rare exceptions - technical apparatus using fuzzy logic or states of quantum physics - all natural and human sciences (including Western philosophy since at least Plato) are based on classical logic, establishing the veracity or falsity of a proposal.
However, classical logic has limitations that have been known since its inception. These situations, which can be expressed in a few simple sentences, are negligently classified among the paradoxes.
The consequences of refusing to deal with these paradoxical situations are most critical, since this gap forces us to blindly focus on our understanding of the world and ourselves.
Since no one can ignore the fact that the modern world is going through an ultimate crisis, any contribution to broadening the scope of possibilities is welcome, and indeed, we might even say, necessary. This is the purpose of this article.
We will begin with a brief history of logic, going back before the appearance of classical logic, where we will see in passing that logic is born of metaphysics. This will lead us to an interposed dialogue between Heraclitus, Aristotle, Granger and Guénon.
We will then propose a formalization of a tetravalent logic with its truth tables, after having explained its necessity (part 2). We will end by applying the framework of this logic to the semantics of some attributes of the manifested and the unmanifested, where we will find each time the conceptions of Tradition (part 3).
case 3: neither P nor not(P) are true, simultaneously.
"All things are born according to the opposition... Change is an upward-descending road and the order of the world occurs according to this road..."
"All things are mutually contrary. "
"The god is day-night, winter-summer, war-peace, satiety-hunger. It changes like when you mix perfumes together; then you name it after their smell. "
"What is cut in the opposite direction is assembled; from what is different is born the most beautiful harmony; everything becomes by discord. "
"It is the disease that makes health pleasant and good, hunger satiety, fatigue and rest. "
"What is contrary is useful; what struggles forms the most beautiful harmony; everything is done by discord. "
"Join what is complete and what is not, what agrees and disagrees, what is in harmony and disagrees; of all things one and one, all things. "
"They don't understand how what struggles with oneself can fit. The harmony of the world is in opposite tensions, as for the lyre and the bow. "
"There is a hidden harmony, better than the apparent and where the god has mixed and deeply hidden differences and diversities. "
"Death of fire, birth for air; death of air, birth for water. "
"The same thing that lives and that which is dead, that which is awake and that which sleeps, that which is young and that which is old; for the change of one gives the other, and vice versa. "
The principle of non-contradiction rejects case 2: one cannot think P and non(P) true at the same time.
The principle of non-contradiction is an axiom, i.e. it is taken as a first truth that helps to demonstrate other theorems, but itself cannot be deduced or demonstrated. This is a relatively recent invention. It was popularized by Plato (428 - 348 BC) in La République (IV, 436b) and especially by Aristotle (~384 - ~322 BC): "It is impossible that the same attribute belongs and does not belong at the same time and in the same relationship to the same thing" (Metaphysics, Gamma Book, chapter 3, 1005 b 19-20).
The excluded middle was introduced by Aristotle as a consequence of the principle of non-contradiction.
The combination of the principle of non-contradiction and the principle of the excluded middle have contributed to the foundation of the so-called classical formal mathematical logic.
In addition to its non-modal syllogistics, Aristotle developed a modal syllogistics in Book I of its Premiers Analytiques (ch. 8-22).
The first formal system of modal logic was developed by Avicenna, who proposed a theory of temporal modal syllogistics. Modal logic as a subject of study owes much to the writings of the Scholastics, in particular Guillaume of Ockham and Jean Duns Scot, mainly for the analysis of assertions on the essence and the accident.
The "polyvalent logics" question the excluded middle since Lukasiewicz in 1910, which returns to the ancient question of "futurs contingents": if a proposal concerning the future could already be characterized in the present as true or false, we should admit that the course of events is determined in advance. Versatile logic challenges the principle of the excluded middle. They recognize values other than the true and the false, they admit modalities such as the possible, or, below that, the impossible (which is a reinforced false), and beyond the necessary (higher degree of the true).
There is now a whole spectra of intermediate logics, ranging from intuitionist to classical logic, depending in particular on the number of modalities (or truth values) and axioms chosen to constitute the logical system.
Which system is the most relevant to use to rebuild our knowledge, after binary logic?
Do sciences really make us discover the reality of things? Do they build the world from scratch in their laboratories, and then force us to believe it?
We have stressed that the construction of logic derives from the knowledge of being, that is, from metaphysics. It is therefore mandatory to look at what Tradition has to offer in this regard. We use a capital letter T to indicate that we go back further than Aristotle and Plato. We started with Heraclitus, we continue in the footsteps of René Guénon, starting by explaining the importance of the ternaries.
One of these two genres is the one where the ternary is constituted by a first principle (at least in a relative sense) from which two opposite terms derive, or rather complementary terms, because, even where the opposition is in appearances and has its raison d'être at a certain level or in a certain domain, complementarism always responds to a deeper point of view, and therefore no longer truly in conformity with the real nature of what it is about; such a ternary can be represented by a triangle whose vertex is placed at the top (fig. 1).
The other genus is the one where the ternary is formed, as we said earlier, by two complementary terms and by their product or resultant, and it is to this genus that the Far Eastern Triad belongs; unlike the previous one, this ternary can be represented by a triangle whose base is on the contrary placed at the top (fig. 2).
If we compare these two triangles, the second one appears to be a reflection of the first, which indicates that, between the corresponding ternaries, there is an analogy in the true meaning of this word, i. e. to be applied in the opposite direction; and, indeed, if we start from the consideration of the two complementary terms, between which there is necessarily symmetry, we see that the ternary is completed in the first case by their principle, and in the second, on the contrary, by their resultant, so that the two complementary terms are respectively after and before the term which, being of a different order, is almost isolated from them. This is further clarified in both figures by the direction of the arrows, going, in the first, from the upper vertex to the bottom, and, in the second, from the bottom to the lower vertex;[...]; and it is obvious that, in any case, it is the consideration of this third term that gives the ternary as such its full meaning.
The consideration of two ternaries like the ones we have just mentioned, having in common the two complementary principles of each other, leads us to some other important remarks: the two inverted triangles which represent them respectively can be considered as having the same base, and, if we figure them united by this common base, we see first that the set of the two ternaries forms a quaternary, since, two terms being the same in both, there are in all only four distinct terms, and then only the last term of this quaternary, located on the vertical line resulting from the first term and symmetrically to it with respect to the base, appears as a reflection of this first term, the reflection plane being represented by the base itself, i. e. being only the median plane where the two complementary terms resulting from the first term are located and producing the last one (fig. 3).
René Guénon developed in more detail the meaning of the quaternary in Le Symbolisme de la croix (1931), which is entirely consistent with the above passage.
impossible (if and only if the proposition is not possibly true; "what cannot but be false").
« Another way of showing the relationships between the four modalities is to arrange them in a square configuration, which goes back at least to Aristotle. The square of the modalities is isomorphic to the logical square of the terms and to that of the form A (universal affirmative), E (universal negative), I (particular affirmative) and O (particular negative) proposals of Aristotelian logic (fig. 4).
This essay is extended by the formal propositional calculation in tetravalent logic, detailed in the second part.
This article is a translation of the original article published in French.
then by establishing the values of the truth tables of the operators NOT, AND and OR and by first demonstrating the equality not(A and B) = not(A) or not(B).
The principle of non-contradiction is the proposal "P and not (P) = FALSE".
implies the proposition: "not(P and not (P)) = TRUE"
implies the proposition:" not(P) or not (no (P)) = TRUE"
implies the proposition: "not(P) or P = TRUE"
implies that "P is TRUE" or "not(P) is TRUE"
so the proposal of the excluded middle is verified.
 Lewis founded modern modal logic in his 1910 Harvard thesis and in a series of articles published between 1912 and 1932, when his book Symbolic Logic, written in collaboration with Langford, was published.
The logicians Brouwer and Heyting in 1930 criticized, in the name of "intuitionist logic", a certain type of reasoning held according to the principle of the excluded middle applied to finite sets. They believe that one has no logical right to infer the truth of a proposal from the falsity of its negation. Heyting does not say that the excluded middle principle is always wrong, but it limits its scope.
The mathematical structure of modal logic, i. e. Boolean algebras augmented by unary operations (often called modal algebras), began to emerge with McKinsey who showed in 1941 that Lewis' S2 and S4 systems were decidable.
 Why a representation in the form of a diamond and not a tetrahedron? The latter would place the Contingency and the areas of the Possible and the Impossible on the same level. It would "shorten" the distance between the Contingency and Necessity. There is no way to justify these assertions. On the contrary, we will see in the last part how useful it is to keep the diamond model.


text:
Cohasset Police Department investigates spate of overnight courier package thefts in the United States
By Timothy Z. Gustavson on	 November 26, 2021 Forestry department
COHASSET – Police Chief William Quigley reports that Cohasset police officers and detectives are working this morning collecting hundreds of letters, postcards and packages that were illegally removed from letterboxes and porches overnight.
Mail and parcels are found on the roads and in the courtyards of the city. Police believe that one or more suspects committed the crimes on Jerusalem Road between Hull Street and Forest Avenue, and again on Forest Avenue and all streets adjacent to Forest Avenue during the night of November 25-26.
To date, more than 40 victims have been identified by the police. Police notified the US Postal Service. The United States Postal Inspection Service is actively working with Cohasset Police to identify the perpetrator (s) and return mail and packages to intended recipients.
Chief Quigley is asking residents who find lost mail or packages to bring them to the Cohasset Police Station at 62 Elm Street. An officer was sent to the station to collect these items and register them. Chief Quigley further encourages residents who are waiting for mail and important packages to contact the sender or track the package using online tools provided by delivery companies.
Cohasset Police would like to share the following advice from the National neighborhood watch to further help prevent package theft:
Consider getting a PO Box at your local post office or having packages delivered to your office
Configure notifications to track your packages
Install a security camera in the area (s) outside of your home where packages can be delivered
Require signature upon delivery to ensure packages are never left unattended
Reschedule delivery or request a postponement of packages during the holidays
Research potential home security technologies and locking device options to protect and monitor packages
Ask your neighbors to collect your packages to keep them in a safe place until you get home
If you find that your package has been stolen, report it to the police immediately.
Sign up for the USPS "Informed Delivery" service, where you can receive a daily email with a photo / scan of the mail you receive that day. To register, click here.
State forestry department searches for acorns and nuts
Forestry Department clears 15,000 durian trees to make way for 20,000 forest trees
The Forestry Department is committed to ensuring the safety of visitors to permanent forest reserves
Forestry Department Prepares for Olive Ridley's Nest in Odisha's Ganjam – The New Indian Express

redpajama_set_name: RedPajamaCommonCrawl


text:
House Democratic Majority Hopes To Iron Out Differences In Key Health Care Reform Legislation During August Recess
Democratic Leaders in the House of Representatives plan to hammer out differences three versions of the America's Affordable Health Choices Act (H.R. 3200) as separately passed by three key House Committees in July before House members return from their August recess in hopes of bringing the agreed to version of H.R. 3200 to the full house in September. Each version of H.R. 3200 would impose significant new obligations, regulations and costs on employers, health insurers and health plans, and employees.
After negotiating a last minute pre-August recess deal with certain Blue Dog Democrat Committee members, the House Energy and Commerce Committee on July 31, 2009 passed its version of H.R. 3200, the America's Affordable Health Choices Act (H.R. 3200). The version of H.R. 3200 passed by the House Energy and Commerce Committee incorporates a series of amendments to the language of H.R. 3200 as originally introduced. For instance, this version of H.R. 3200 provides incentives for states to adopt certain tort reforms, provides for a public plan option that would reimburse physicians based on negotiated rates rather Medicare rates, and would allow states to offer both state-based heath insurance exchanges and health insurance co-ops. To review H.R. 3200 as amended by the House Energy and Commerce Committee, see here.
The approval by the Energy and Commerce Committee of its version of H.R. 3200 follows the July 17, 2009 approval by the House Ways and Means Committee and Education and Labor Committee of their own versions of H.R. 3200. For details on the version of H.R. 3200 approved by the House Ways and Means Committee, see here. For details on the version of H.R. 3200 approved by the House Education and Labor Committee, see here.
Leading House Democrats have announced their intention to work to resolve differences between these three versions of H.R. 3200 as passed by these Committees during August recess in hopes of bringing the agreed to version of H.R. 3200 to a vote of the full House of Representatives in September.
Meanwhile, House members from both parties also generally are using the August recess as an opportunity to reconnect with local constituents on health care reform and other core issues.
The author of this article, Curran Tomko and Tarski LLP Partner Cynthia Marcotte Stamer has extensive experience advising and assisting employers and other health plan sponsors, insurers and others about health benefit and other benefits, human resources and health care matters. The current Chair of the American Bar Association Real Propoerty, Probate & Trust Section Employee Benefit Plans and Other Compensation Committee and former Chair of the ABA Health Law Section Managed Care & Insurance Group, she regularly advises these and other clients about the design, administration, defense and regulation of health benefit, wellness and disease management, managed care, onsight wellness, and other benefit and insurance regulations, legislative and regulatory reforms impacting these and other arrangements, and related matters.
We hope that this information is useful to you. If you need assistance monitoring, evaluating or responding to these or other proposed health care or other regulatory reforms or with other health care compliance, risk management, transaction or operation concerns, please contact the author of this update, Curran Tomko Tarski LLP Health Practice Group Chair, Cynthia Marcotte Stamer, at (214) 270-2402, cstamer@cttlegal.com or your other favorite Curran Tomko Tarski LLP Partner.
We also encourage you and others to join the discussion about these and other health care reform proposals and concerns by joining the Coalition for Responsible Health Care Reform Group on Linkedin, registering to receive these updates here.
If you or someone else you know would like to receive future updates about developments on these and other concerns, please be sure that we have your current contact information – including your preferred e-mail – by creating or updating your profile at here or e-mailing this information to cstamer@cttlegal.com. If you prefer not to receive these updates via e-mail in the future, e-mail your request with "remove" in the subject to support@solutionslawyer.net.
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The festival marked the end of Ramadan. It was the biggest celebration of the Company since its creation in 2000.
Directors, Management, Staff and other stakeholders, jointly celebrated the end of Ramadan 2017 on July 25th in Johor Bahru.
It was an exciting evening for all the participants and a special occasion to mix minds and spirits together.
The event started with a speech of MMHE-ATB's CEO – Danilo SERIOLI who explained important results achieved during the previous year and the mandatory path to follow in order to increase Company's effectiveness and so tackle the negative economic scenario in the oil & gas market.
A special internal Committee planned and managed the event, making it a milestone that can't be forgotten in the future.
More than 80 people from 4 Countries attended the gathering, making it the biggest Hari Raya celebration of the Company since its creation in 2000.


definetly not the best TMDC invtro, but it was fine.
Good invitation, some sweet graphics.
Not the "coolest" tmdc invtro (5 remains my favorite), but definitely the most visually interesting. Some pretty damn neet effects, with a cool piano ambient tune.
And the name of the library ROCKS!!
Great music, but the visuals were a bit boring. Still very nice.
Yay! It's here! Cool invitation.
nah, i've seen more impressive tmdc-invtros.
Taat is becoming one of my favourite groups. This prod didn't disturb that feeling in any way. Missed Karpo's music though.
It's okay, but there's been better tmdc invitations. And the music isn't quite my cup of tea.
This piece has great music, so it's a pity that it's just a text-mode demo.
I didn't exactly love the music, but thank-you thank-you thank-you thank-you for something other than the usual boom-boom silliness. How about some bluegrass next time? Yeehaw!!!
not exactly awesome when it comes to the color composition but hey, i really like it, and it's nicely built up along the music and all.. coolness.
even fun if you press esc!
powered by libCaca...its the shite !
rulez added on the 2009-12-21 19:17:41 by ɧ4ɾɗվ.
page created in 0.016524 seconds with 16 queries.


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Windows 2008 architecture based on OpenSource
Cheers, Another Win for OpenSource, finally Microsoft is learning something from open source and moving.
What is really well in open source development and technology, the following things stand out:
Modular architectures
You can find these wherever you see participation at scale – and often a rearchitecture to a more modular system precedes expanded participation. Great examples of this are Firefox, OpenOffice, and X11 – from both the historical rearchitecture and the increased participation that resulted. The Apache HTTP server and APR are good examples that have been modular for as long as I can recall.
Programming language agnostic
A given project uses a consistent language, but there are no rules on what languages are in scope or out of scope. Being open to more languages means opportunity to attract more developers – the diversity of PHP/Perl/Python/Java has been a core driver in the success of a number of projects including Linux.
Feedback-driven development
The "power user" as product manager is a powerful shift in how to build and tune software – and this class of users includes developers who are not committing code back, but instead submitting CRs and defects – resulting in a product that better fits its end users.
Built-for-purpose systems
Most frequently seen in applications of Linux, the ability to build a system that has just what is needed to fulfill its role and nothing else (think of highly customizable distributions like Gentoo or BusyBox, as well as fully custom deployments).
Sysadmins who write code
The ability of a skilled system administrator to write the "last mile" code means that they can make a technology work in their particular environment efficiently and often provide good feedback to developers. This is so fundamental to Unix and Linux environments that most sysadmins are competent programmers.
Standards-based communication
Whether the standard is something from the IETF or W3C, or simply the implementation code itself, where these are used projects are more successful (think of Asterisk and IAX2) and attract a larger ecosystem of software around them.
So where did we apply these ideas to the development of Windows Server 2008?
Modular architectures was applied in multiple areas, but the one that stands out most to me is Internet Information Server 7 (IIS7). IIS7 has been rearchitected for flexibility as 40 individual modules, enable more to be written by community developers or delivered as out-of-band releases. This has already enabled performance improvements and independent evolution, and I expect to see further enhancements.
Programming language agnostic is something we've delivered on with support for PHP on IIS7 and the enhancements to FastCGI (which can be used by any of the P* languages). We set a goal of having PHP certified on Windows Server 2008, and we've achieved that. We'll continue to improve runtime, security, and manageability support for non-.NET languages and the applications that are built on them, as well as testing the full stacks of PHP-based applications running on Windows Server, IIS, and SQL Server.
Feedback-driven development based on developer and customer trials (RDPs, TAPs, and Betas in our process) led to a range of "feature completion" developments that connected different components – like connecting Windows Firewall with Active Directory central policy, and the end-to-end improvements in SMB 2.0. Features like the RODC (Read-Only Domain Controller) have become more and more solid through experience with early alpha and beta customer deployments, and requests to enforce things like BitLocker encryption of user disks from a central authority have achieved full support.
Built-for-purpose systems such as DNS, DHCP, file and web serving can be created through wizard-driven configuration thanks to Windows Server Core. The goal of having a minimum attack surface and a small hardware footprint, inspired by the capabilities mentioned above, yet achievable by a broad base of admins has been achieved. Additionally, this has created an opportunity for Windows admins to become much more knowledgeable about the low-level structure of the operating system.
Sysadmins who write code are first-class citizens in the PowerShell-driven infrastructure. We've increased Windows administrators' opportunity to master the full surface area of WMI and demonstrate that mastery in reusable, low-level scripts. As we evolve this to support multiple language bindings and bash aliasing, this should become a comfortable home for highly skilled sysadmins.
Standards-based communication such as in CardSpace (with support for X.509, SAML, Kerberos tokens, and more) and the Web Services stack (not only are all 38 Web Services standard under the Open Specification promise, but our implementations have achieved a high level of interop with Apache's Axis web services stack), and beta support for emerging standards like Xen virtualization represent a small subset of the standards built into Windows Server 2008.
Port25 has a discussion going on about it.
Labels: microsoft, open source, windows


text:
Q: Why am I getting gson Exception: Expecting object found? I am using the GSON API 1.7.1 sometimes having following error. Is there a bug for this version? Do I need to upgrade the current version 2.x.x
com.google.gson.JsonParseException: Expecting object found: "<!DOCTYPE"
        at com.google.gson.JsonObjectDeserializationVisitor.visitFieldUsingCustomHandler(JsonObjectDeserializationVisitor.java:100)
        at com.google.gson.ReflectingFieldNavigator.visitFieldsReflectively(ReflectingFieldNavigator.java:63)
        at com.google.gson.ObjectNavigator.accept(ObjectNavigator.java:120)
        at com.google.gson.JsonDeserializationContextDefault.fromJsonPrimitive(JsonDeserializationContextDefault.java:85)
        at com.google.gson.JsonDeserializationContextDefault.deserialize(JsonDeserializationContextDefault.java:56)

The server is google push notification server GCM,
Here is my client code.
Gson gson = new Gson();
com.sun.jersey.api.client.ClientResponse webResponse=
                resource.header("Authorization", authorizationKey).
                header("Content-Type", MediaType.APPLICATION_JSON).
                post(com.sun.jersey.api.client.ClientResponse.class, payloadStr);
String responsePayload = webResponse.getEntity(String.class);
GcmResponse response = gson.fromJson(responsePayload, GcmResponse.class);   ===>>> Exception point

A:
Is there a bug for this version?

No. Looks like your server is returning a non-JSON response or you're passing wrong parameters, this has nothing to do with the version you're using.
Try to check if the server is working as expected and is returning a JSON.

A: <!DOCTYPE is not valid Json; your server sometimes sends the wrong messages to your client. Since your client works 99% of the time, the problem is clearly in the server somehow, not the client.
However, since you've only provided us information here from the client side, there isn't enough for us to fix the problem. The best thing to do would be to attempt to capture the complete error message, then use searches or post a different question "Why does my android-scm server send messages that begin with <!DOCTYPE when they should be Json?"
To capture this complete errant message, I would do:
if(response.startsWith("<!DOCTYPE")) {
    someLoggingMethod(response);`
} else {
    // process the response

redpajama_set_name: RedPajamaStackExchange


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Medical detoxification initiates the recovery process for drug and alcohol abusers by providing them a safe method of withdrawal from addictive substances and medically stabilizing them. Drug detox takes place in an outpatient or inpatient setting and usually under a physician's care. Detoxification is critical for individuals who have taken drugs that 1) are not addressing the issue for which they were initially prescribed, 2) have become addictive or 3) are causing dangerous and undesirable side effects. Discontinuing prescription medication, drugs or alcohol without pursuing a medically-supervised withdrawal system may be fatal or result in severe health problems.
Alcohol detox, which usually takes place in an inpatient medical environment or rehab , enables patients to be cleansed of the alcohol in their system. Effective drug or alcohol detox programs medically manage patients' psychological and physical withdrawal symptoms such as convulsions, tremors, seizures, headaches, sweat, depression, and anxiety. Drug or alcohol detox is available for individuals seeking to withdraw from benzodiazepines, alcohol, heroin or other opiates (i.e. Oxycontin, Vicodin, methadone), and psychotropic medication. For instance, buprenorphine or Subutex is utilized to detox opiate users and addicts, helping them to comfortably and safely tackle withdrawal symptoms.
Staff at a drug or alcohol detox center first meet with and interview the patient, analyze his or her medical history and evaluate tests performed at the treatment center. They then create a customized detox program and protocol for the patient and administer the detox medication, regularly monitoring the latter's progress and condition. The staff continues to dispense the medication at appropriately-reduced dosage until the patient has been fully detoxified. The length of a detox program often depends on the duration and frequency of drug use, type of drug, individual's age, present health status and medical conditions. Drug or alcohol detox is usually completed in 7 to 14 days, and the process will also shed light on whether the client should pursue ongoing drug addiction treatment.
For centuries, Chinese and Ayurvedic therapeutic systems have applied body detox principles which involve cleansing the body of impurities in the blood, nourishing it with invigorating nutrients, and resting it. Through detox regimens, toxic substances such as parasites, food chemicals, and heavy metals are removed from the body, thus revitalizing the individual and protecting him or her from illness. A detox diet supplements the body's own cleansing capacities by (1) enhancing blood flow, (2) allowing the organs to rest via fasting, (3) utilizing healthy nutrients to re-energize the body, (4) facilitating elimination through the skin, kidneys and intestines, and (5) stimulating the liver's toxin-eliminating function.
Juice fasting or a modified dietary regimen consisting of consuming more fruits and vegetables and avoiding foods that adversely impact the body.


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Home » talk amongst yourselves » question of the day: What holidays lacking horror movies should get them… and in what form?
It seems as if Hollywood has taken every opportunity to tie in a bloody chainsaw massacre or teen bloodbath to almost every single holiday going. But not all of them. Today is Good Friday (a bank holiday here in the U.K.) and there hasn't been a Good Friday horror movie (unless we count The Passion of the Christ). Hop is verging on being an Easter horror movie, but nothing even comes close to being a commemorative slasher flick for Easter Monday, also a bank holiday here.
Today also happens to be Earth Day. No horror movie.
Next monday, May 2, is the May Day bank holiday in the U.K. No workers' uprising massacre movie that I'm aware of. This coming Friday, April 29, the U.K. is getting yet another bank holiday for the royal wedding of Prince William and Kate Middleton. I'm not sure if a royal wedding massacre would work as a movie, but suddenly Bank Holiday is sounding pretty ominous.
What other holidays lacking horror movies should get them… and in what form?


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Artist Caroline Wells Chandler (l) with pieces from his 'Queering the Lines' exhibit on display at Art League Houston now through April 11. Photo: Andres Alcoser
ArtArts & Entertainment
'Queering the Lines'
Guest Contributor March 26, 2015
An interview with trans artist Caroline Wells Chandler
by Iva Kinnaird
This will be a very gay show. This is how New York-based transgender artist Caroline Wells Chandler first described Queering the Lines, which is currently on view at Art League Houston (ALH). And the show does not disappoint. The exhibition features paintings of celestial bodies in ceramic drag, as well as hand-crocheted drawings and sculptures of bears, antennas, equine familiars, and the axis mundi to explore notions of queerness in all its rainbow spectrum glory!
It's a happy space, and it's fun to see (and roll around on the ground with) the pillowy forms that are scattered across the floor of ALH's Front Gallery. Chandler's crocheted works sit like child-like drawings on the gallery's walls. They smile and they wave, playfully exploring themes of desire and identity.
I was lucky enough to chat with Chandler during his stay in Houston, and ask him a bit more about the exhibit and his practice.
Iva Kinnaird: I noticed some similarities to Mike Kelley in your work with the toy-like life-sized crocheted bears. Looking at your website, I assume you are a fan. How has he influenced you and the way you work?
Caroline Wells Chandler: I'm less interested in establishing lineage with Mike Kelley as an artist and more interested in my work coming out of a feminist craft trajectory for several reasons. Kelley got a lot of flack for colonizing female spaces without real risk because he maintained an authoritative male anthropological position. I see this detached position as a safe place, devoid of real risk, because the personal ceases to be political. It is also important to note that he works with secondary source material in that he gathers and sorts. Furthermore, he doesn't alchemically alter the status of the materials that he works with. In his work, hierarchies are fixed. This perception is treated as a "truth" that I find problematic. Kelley did open things up materially for artists in terms of allowing for low toy culture to be used as material; however, most of his work with crochet would not have been possible without the hard work of the feminist art movement. Overwhelmingly, this historical fact seems to be smudged-out in his work.
One idea that I glean from Kelley's work that is important to me is how an individual maintains autonomy within the face of culture. Differing from Kelley's singular voice critique position, I'm most interested in critical engagement. Critical engagement allows for the simultaneity of multiple subjectivities coexisting in the same place at the same time in effort to explore constructs. With critical engagement, hierarchies are flattened. Nobody wins, and there isn't a right or wrong or good or evil.
The moon wall pieces came after a series of similarly formed cookie pieces. They seem (to some) to be delicious. I think they look toxic and more radioactive than edible. Your thoughts on that duality?
I really love the haloed icon in altarpiece painting. Hands down, Matthias Grunewald's Isenheim Altarpiece is perhaps the greatest work of art in the world. I love the Tilda Swinton look-alike resurrected Jesus. It is so perfectly psychedelic and suggests wonderful ideas regarding boundary dissolution. Especially, I love the torture scene of St. Anthony. I would bet a large sum of money that the beasts in Where the Wild Things Are are based off of the fantastical demons. Interestingly, the hospital that the piece was made for was primarily used to treat ergotism. Ergotism results from ingesting rye infected with fungus. Vivid hallucinations ensue. A strain from that fungus was later the source for the hallucinogen LSD. There is something synchronistic about all that that resonates with me regarding how I think about making things.
Some of Chandler's 'Queering the Lines' moon wall pieces. Photo: Andres Alcoser
Another altarpiece that I enjoy is Jan Van Eyck's Ghent Altarpiece. Specifically I really like the faces of the angels that are singing in the choir. There is a synesthetic quality about them in that their contorted faces seem to suggest different tones or sound. I like to think of the moons as the divine gaylien ancestors to that choir of angels.
I'm really interested in the politics of comfort, and how something that is comfortable to one might be oppressive to another. More obviously, in the show, some people saw the bears as fun and others creepy, which is a delight since the teddy bear is the voodoo doll of the cult of domesticity. Most Americans eat lots of food that looks psychedelic or on par with the coloring of toxic insects. The pieces are not intended to be a critique of food, but more so an exploration of color.
Most of my friends say that my work is incredibly warm, generous, and scary, which I think are all accurate adjectives to describe me. Those words are what I think about when I think of the sublime. For me the neo-sublime integrates the figure within the environment creating a permanent state of boundary dissolution and formlessness. It also simulates the process of integrating the subconscious with the conscious mind. I see this best expressed in the moons.
We all love the cowboys [Howdy and Lone Ranger] in the show. You mentioned spending time in Texas as a child. How did you decide what type of characters to create and include in this show?
One of Chandler's cowboys in his 'Queering the Lines' exhibit. Photo: Iva Kinnaird
When I am given an opportunity to do a show on my terms, I really enjoy responding to the architecture of the space to create an environment. This show was a gift for a number of reasons, but especially because I was not rushed and I was allowed to plan it over a year. I stared at a plan for the space and made several sketches of possibilities in a spiral notebook. I began to really panic in October to get my act together and start actually making the work, which is incredibly labor intensive, because all of it is hand-crocheted.
I like esoteric lore, alchemy, mythology, and shamanism coupled with my own experience. I completed my undergraduate studies at Southern Methodist University in Dallas, and lived in Tyler, which is where my mother's family is from, for two years after graduating from SMU. One thing that I heard repeatedly while I lived in Texas was that if they legalize gay marriage, then people will marry their horse. That was always really interesting to me, because it was such an absurdly creative conclusion. To me it seemed perfect to cannibalize that idea and make a room of steers and queers. I knew that I wanted a wall depicting the result of unbridled desire with the children of a forbidden love. Centaurs of course are the perfect form for this. The first centaur I made was about a year ago. It is titled Wonder Boi. For Wonder Boi I was thinking about Trojan horses and how they relate to passing and how passing in some situations allows one to know how they might stand if they are considered an insider when in reality they might actually be an outsider.
Howdy was made back in August. I wanted to have him in the show but I thought that cowboys were too obvious, so I put him aside until the other images came together. The cowboys are essentially leather daddy bears of a different order. I think Texas is a breeding ground for politically empowered queer people. The emphasis on rugged individualism coupled with an everything-is-bigger-in-Texas attitude has potentially explosive implications.
I wasn't sure until February that the moons would be in the show. After I made Icaro, I was certain. Icaro named itself. I looked it up and was delighted to see pictures of Icarus, which is very different in tone for what I was going for but still interesting and important. The ending of Icaro is "o," which is Carl Jung's structure for the self in the process of individualization. The ending of Icarus is "us," which for me is the opposite of "o" because the self becomes integrated and at a great cost if one is to think of the mythological story of Icarus. An icaro is a song learned from a plant spirit that is sung by the Shipibo Indians in ayahuasca ceremonies. By controlling the tone and the pitch of their voice, the shaman's song creates a synesthetic visionary experience of color for the participant in the ayahuasca ceremony. The etymology of icaro is the Quechua work ikaray, which means to blow smoke in order to heal. Icaro looks as if they are playing a flute. I like to think of the moon paintings as songs of color. This resonates with me further because my name is Caroline, which means to sing joyfully.
One of Chandler's 'Queering the Lines' centaurs. Photo: Iva Kinnaird
The arm/wand/antenna forms on the floor look like chakapas, which are used by the Shipibo shamans during ayahuasca ceremonies to clear out bad vibes and direct energy. I also like to think of them as a chopped-up regenerating form. When fishermen tried to kill starfish, they mistakenly thought the best method was to chop them up into tiny bits. The starfish regenerated fivefold. The largest antenna in the room is the Axis Mundi, which is also known as the world tree. It is thought that the axis mundi is a connector or bridge for shamans to travel to lower and higher realms in effort to bring back knowledge. Commonly, the alchemical figure of the hermaphrodite is seen in relation to the axis mundi as a symbol of unity and immortality. This of course is why Orgin resides at the base.
Orgin references Gustave Courbet's Origin of the World. I wanted to make a celebratory and fierce genderqueer archetypal figure. An influence for Orgin's conception is the guardian figures in Tantric Himalayan Buddhist art. They are sometimes mislabeled as ferocious, but fierce is more accurate because they are jolly and humorous and serve as protector deities. Orgin depicts a figure with top surgery and what I hope reads as a pulsating and moving rainbow for genitals. The rainbow genital choice is in response to what I view as a strange obsession of the public regarding the genitals of trans and queer bodies.
Despite conservative politics in Texas, a lot has changed in the past 10 years in terms of sentiments regarding LGBTQ people. I remember watching Brokeback Mountain in the theaters in Dallas, and people actually booed. I did not have one out queer teacher or adult in my life until graduate school. Deb Kass was the first teacher who openly talked about being a lesbian. Part of me really wished that I was a lesbian too, because all of the best living painters are lesbians. I was also fortunate to take Dean Daderko's Queer Strategies seminar, which changed my life, because it provided me words that were not a part of my preexisting vocabulary to express how I felt grounded in my body.
'Queering the Lines' at Art League Houston. Photo: Iva Kinnaird
How much of your work is portraiture or self-portraits? And what makes a work a portrait versus a created character?
A good portrait traps the essence of a person and is best when it reveals something unexpected about who that person is, which may not be immediately obvious. A created character does not have to play by those same rules, and I would argue that perhaps a character has a narrative or literary function. I'm less interested in narrative and more interested in the works having a literary function primarily in terms of visual literacy. This is referenced in the bodies of the figures in that they simulate text. Text of course is the building blocks of language, and language creates the realities we navigate, and how we do so in our bodies.
I make things that I need to see. I make things that reflect my interests. I tend to make things that make me feel good or laugh, because they are bombastic, dementedly funny, and empowering. A lot of the smiles remind me of the awkward faces that little kids make when they are getting their picture taken. I like to joke around with my partner and make those kinds of faces. Some of the pieces are inspired by my friends. At times some of the work looks like me, but more often most of the work feels like me.
The work [specifically with Orgin and the Dreamer Bear] presents images that are playful and have a child-like innocence to them while also being aware of their own sexuality. How do you view the works in relation to this innocence and awareness of sexualized identity?
I'm not really sure of the sexuality or sexualized identity of Orgin or Dreamer. Based on the installation it looks like Orgin is about to be plowed by Icaro, and planets seem to be shooting out of their pulsating rainbow cave. Further adding confusion as to where planets come from, a gaseous planet seems to be farted out of Icaro's butt-hole. Dreamer has a girthy penis that begins to read as a grafted strap-on because of the lack of balls and a meticulously constructed penetrable vagina. They all have a self-possessed confidence in their bodies.
Prior to when culture sinks its teeth in, children tend to have a very open relationship to their bodies until they learn shame. I'm very interested in that pre-cultural state prior to propaganda, because I find it to be liberating and affirmational.
In what ways does your own identity (specifically as someone who identifies as queer) manifest in the works?
If anyone has made it to the end of this interview, I believe that they would agree that your question has been answered thoroughly.
Caroline Wells Chandler's Queering the Lines will be on view at Art League Houston through April 11. Born in Norfolk, Virginia, Caroline Wells Chandler currently lives and works in New York. He completed his foundation studies at the Rhode Island School of Design and received his BFA cum laude from Southern Methodist University in 2007. He has shown at numerous institutions including: Zurcher Studio (NY), Anna Kustera (NY), Field Projects (NY), Vox Populi (PA), Sanctuary (PA), N'Namdi Center for Contemporary Art (MI), Open Gallery (TN), The Bascom (NC), Arlington Arts Center (VA), and the Stieglitz Museum ('s-Hertogenbosch, The Netherlands), among others. Chandler is a 2011 MFA recipient in painting at the Yale School of Art where he was awarded the Ralph Mayer Prize for proficiency in materials and techniques. He lives and works in New York. Queering the Lines will mark the third solo show within a year for the artist.
Art League Houston Caroline Wells Chandler Houston Art League queer trans transgender
¡Ay, papi!
Art with a Global Perspective
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Queer Lutheran Preacher Calls on Church to End White Supremacy


text:
From Aprons to Lab Coats: The Art and Science of Home Economics
September 11, 2021 • Education, Everyday Life, Food and Drink, Mansfield, Women
Nutrition class, Connecticut Agricultural College, ca. 1920-1935
- Thomas J. Dodd Research Center, University of Connecticut Libraries and Connecticut History Illustrated
By Shirley T. Wajda
Created to train men in the skills of farming at a time when agriculture and rural life were feared to be in decline, the Storrs Agricultural College (the precursor to University of Connecticut) also trained women in what was first called domestic science and later home economics.
Women were first admitted to the Storrs Agricultural College in 1893, when Domestic Science was added to the curriculum. In 1899 the institution was renamed the Connecticut Agricultural College. Its 1906-07 Bulletin offers much food for thought about just what higher education was and meant at the turn of the 20th century. For example, "Course No. 7" in Home Economics required courses in English, German, History, Algebra, Geometry, Elocution, and Economics—all part of a liberal arts curriculum. But women students were also required to take courses related to farming: Poultry, Practical Poultry, and Ornithology; Botany, Horticulture, and Forestry; and Meteorology.
And then there were the domestic science courses: Bookkeeping, Sewing and Dressmaking, the wonderfully titled Chemistry of Cleaning, Bacteriology, and, of course, Cooking.
A "Miss Thomas" taught this course:
Cooking—This work consists of courses of cookery of a strictly economical character. Correlated with it is a brief study of the composition of foods. The foods cooked are taken up with regard to the food principles they represent. The comparative food and market value and the effect of heat and moisture are noted; also the uses of foods in the body and their digestion and assimilation. The combination of food materials is discussed, especially those most easily obtained upon a farm. The food principles, taken in their natural sequences, are illustrated by the cooking of cereals, vegetables, eggs, meat, fish, peas, and beans. The various methods of making batters and doughs light are discussed. Biscuits, muffins, breads, cakes, and pastry are made. Later comes the more advanced work of salads, desserts, and other made dishes, canning, pickling, and preserving. The economy of material, time, labor, and fuel is brought before the pupil, as are accuracy of measurement, neatness, method, and system.
Cooking class, Connecticut Agricultural College, ca. 1906 – Thomas J. Dodd Research Center, University of Connecticut Libraries and Connecticut History Online
By the 1920s, the national home economics movement had adopted a more scientific approach to the field, supported by legislation such as the Smith-Lever Act (1914) and state aid to teach home economics, to study food, vitamins, and diet, and to survey and examine health and hygiene among the rural and urban poor. Though many Americans would consider home economics old fashioned, historians agree that the home economics movement provided the means through which women entered higher education.
Food Needed to Win the War Comes from Washington
Benjamin Silliman and Soda Water – Who Knew?
The Hartford Wheel Club: Disparity in the Gilded Age
Elizabeth W. Coe Demands the Right of Jury Service
Video – Home Front: Connecticut During World War II – Civil Defense
New Canaan's Pioneering Female Physician
Hidden Nearby: Harwinton's Catlin Trough
A Valley Flooded to Slake the Capital Region's Thirst
Memorial Day 1920 Brings a Changing of the Guard


text:
« Graded on a Curve: New in Stores for November 2019, Part Three
TVD Radar: Mariah Carey, "All I Want For Christmas Is You"
vinyl in stores 12/20 »
TVD Premiere:
Gibson Wilbanks,
Gibson Wilbanks
By Mike Olinger | Published: November 21, 2019
Georgia-based back porch folk duo Gibson Wilbanks are keen to bring back good old-fashioned music, conceived in country, simmered in soul, and sung from heart.
It's fitting that the band is dropping their debut record on vinyl, as this is really the ideal format to digest their high fidelity 8-song debut. Both singers possess a rich vocal tone, which when combined, makes for a classic sounding blend that elevates the sum of its parts. The tracks are adorned with smooth production nuance, yet the embellishments are minimal, allowing the two singers enough room to explore their potent harmonies.
Standout tracks like the plaintive "Oh Sweet Baby" and the cinematic "Green Grass High Tides" make one ponder how "Bro-country" ever came to dominate the genre. "We feel that the Country Music lovers are starved for real bands with thoughtful lyrics," the duo assert. "Like Zappa says, 'Music is the only religion that delivers the goods.' And when it doesn't, it doesn't last or stand the test of time."
Gibson Wilbanks' limited edition vinyl release is available to purchase via Bandcamp.


text:
#include "SubString.h"
#include <list>
#include <vector>

//	1
//-----Basic structures used by the assembler: Line, Instruction, Directive

struct Line
{
	SubString LineString;
	int LineNumber;
	Line(){}
	Line(SubString lineString, int lineNumber);
};

struct Instruction
{
	SubString InstructionString;
	int LineNumber;
	std::list<SubString> Modifiers;
	std::list<SubString> Components; //predicate is the first optional component. Then instruction name (without modifier), then operands(unprocesed, may contain modifier)
	bool Is8;	//true: 8-byte opcode. OpcodeWord1 is used as well
	unsigned int OpcodeWord0;
	unsigned int OpcodeWord1;
	int Offset;	//Instruction offset in assembly
	bool Predicated;//indicates whether @Px is present at the beginning

	Instruction(){}
	Instruction(SubString instructionString, int offset, int lineNumber);
	void Reset(SubString instructionString, int offset, int lineNumber);
};

struct Directive
{
	SubString DirectiveString;
	int LineNumber;
	std::list<SubString> Parts; //Same as Components in Instruction
	Directive(){}
	Directive(SubString directiveString, int lineNumber);
	void Reset(SubString directiveString, int lineNumber);
};
//-----End of basic types

//	2
//-----Structures for line analysis: ModifierRule, OperandRule, InstructionRule, DirectiveRule
//this enum is largely useless for now
typedef enum OperandType
{
	Register, Immediate32HexConstant, Predicate,
	Immediate32IntConstant, Immediate32FloatConstant, Immediate32AnyConstant,
	GlobalMemoryWithImmediate32, ConstantMemory, SharedMemoryWithImmediate20, Optional, Custom,
	MOVStyle, FADDStyle, IADDStyle
};

//Rule for specific modifier
struct ModifierRule
{
	SubString Name;// .RZ would have a name of RZ

	bool Apply0; //apply on OpcodeWord0?
	unsigned int Mask0; // Does an AND operation with opcode first
	unsigned int Bits0; //then an OR operation

	bool Apply1; //Apply on OpcodeWord1?
	unsigned int Mask1;
	unsigned int Bits1;

	bool NeedCustomProcessing;
	virtual void CustomProcess(){}
	ModifierRule(){}
	ModifierRule(char* name, bool apply0, bool apply1, bool needCustomProcessing);
};

//Modifiers are grouped. Modifiers must be present in the correct sequence in which modifier groups are arranged
//Different modifiers from the same group cannot appear at the same time
//For example, FMUL has 2 modifier groups
//1st group: .RP/.RM/.RZ
//2nd group: .SAT
//So if .SAT is to be present, it must be the last modifier
//Only one modifier from the first group could be present
struct ModifierGroup
{
	int ModifierCount; //number of possible modifiers there are in this group
	ModifierRule**  ModifierRules; //point to the modifier rules
	bool Optional; //whether this modifier group is optional
	~ModifierGroup();
	void Initialize(bool optional, int modifierCount, ...);
};

//Rule for processing specific operand
struct OperandRule
{
	OperandType Type;//not really useful.
	//bool Optional;

	OperandRule();
	OperandRule(OperandType type);
	//the custom processing function used to process a specific operand(component) that must be defined in child classes
	virtual void Process(SubString &component) = 0;
};

//When an instruction rule is initialized, the ComputeIndex needs to be called.
//They need to be sorted according to their indices and then placed in csInstructionRules
struct InstructionRule
{
	char* Name;
	int OperandCount;
	OperandRule** Operands;

	int ModifierGroupCount;
	ModifierGroup *ModifierGroups;

	bool Is8;
	unsigned int OpcodeWord0;
	unsigned int OpcodeWord1;

	//If NeedCustomProcessing is set to true, the components of an instruction SubString
	//will not be processed according to the operand rules. Instead, the CustomProcess function
	//will be called
	bool NeedCustomProcessing;
	virtual void CustomProcess(){}
	int ComputeIndex();
	InstructionRule();
	InstructionRule(char* name, int modifierGroupCount, bool is8, bool needCustomProcessing);
	void SetOperands(int operandCount, ...);
	~InstructionRule();
};

struct DirectiveRule
{
	char* Name;
	virtual void Process() = 0;
	int ComputeIndex();
};
//-----End of structures for line analysis

//	3
//-----Abstract parser structures: Parser, MasterParser, LineParser, InstructionParser, DirectiveParser
struct Parser
{
	char* Name;
};
struct MasterParser: Parser
{
	virtual void Parse(unsigned int startinglinenumber) = 0;
};
struct LineParser: Parser
{
	virtual void Parse(Line &line) = 0;
};
struct InstructionParser: Parser
{
	virtual void Parse() = 0;
};
struct DirectiveParser: Parser
{
	virtual void Parse() = 0;
};
//-----End of abstract parser structures

//	9.0
//-----Label structures
struct Label
{
	SubString Name;
	int LineNumber;
	unsigned int Offset;
};
struct LabelRequest
{
	// Index of the requesting instruction in kernel
	unsigned RequestIndex;
	//std::vector<Instruction>::iterator InstructionPointer;
	SubString RequestedLabelName;
	//bool Zero;
};
//-----End of Label structures
#else
#endif

redpajama_set_name: RedPajamaGithub


Doncaster Council's planning committee has approved plans for a new Waste Transfer Station (WTS) at Kirk Sandall Industrial Estate, subject to confirmation by the Secretary of State.
The WTS will reduce the need for a large number of refuse collection vehicles and their crews repeatedly having to travel to and from Manvers to dispose of waste. Instead, waste will be taken to the WTS at Kirk Sandall before being loaded into articulated vehicles which can carry a load the equivalent of up to four refuse collection vehicles.
The design and operation of the proposed WTS has been carefully considered to minimise the impact of the facility on neighbouring communities.


text:
Báró nagyfalusi Serédy Zsófia (1660. körül – 1710) magyar várúrnő, a báró és gróf csíkszentkirályi és krasznahorkai Andrássy család egyik ősanyja.

Életútja

Nincs pontos adat születési dátumáról, minden bizonnyal szülei esküvője (1655) után, 1660. körül születhetett. Rangos nemesi családból származott, szülei Serédy Benedek és Újlaky Borbála voltak. Kilenc testvére volt. 1679. január 12-án ment férjhez a nála jóval idősebb Rhédey Ferenc kolozsi főispánhoz, akinek a vele való frigy a második házassága volt. Két gyermekük született, Krisztina és Anna. Első férje 1684-ben elhunyt. 1689. december 20-án újraházasodott báró Andrássy István kuruc generálissal. Andrássy Istvántól két fia született, Ferenc és József. Andrássy József a család betléri ágának megalapítója volt. 1695-ben hímzett egy úrasztali kendőt, mely a berzétekőrösi református egyház tulajdonában volt. Köztudott volt második férjének Korponayné Géczy Juliannával viszonya, mely igazi megalázás lehetett Zsófia számára, melyből viszont nem sokat tapasztalt, mivel Zsófia 1710-ben elhunyt. A krasznahorkaváraljai plébániatemplomban temették el, majd a már említett vár kápolnájába helyezték el. Természetesen mumifikálódott holtteste túlélte a történelmi katasztrófákat, a krasznahorkai vár 1818-as és 2012-es tűzvészét is. Ennek oka a kápolnának a mumifikáció kedvező tényezői voltak. A múmia másik érdekessége, hogy jobb keze kissé meg van emelve – valószínűleg egy Biblia volt alatta, amely idővel szétmállott.

Alakját Jókai Mór A lőcsei fehér asszony című romantikus regényében örökítette meg, amely mű férje, Andrássy István románcát boncolgatta.

2016. június 9. és szeptember 18. között volt megnyitva az életéről szóló kiállítás a betléri Andrássy-kastélyban Zsófia – Krasznahorka úrnője címmel. Különösen azért, mert sokan megkérdőjelezték azt, hogy valóban Serédy Zsófia múmiája van-e a pompás szarkofágban, mivel a holttestben sokan Dőry Teréz arcmását fedezték fel. Végül az illetékes intézmények megerősítették, hogy a tetem személyazonossága Serédy Zsófiáé. A kiállított relikviák között ott volt Zsófia dúsan díszített későreneszánsz szekrénye is és annak eredeti tartalma, amelyet feltehetőleg II. Rákóczi Ferenc ajándékaként került a várba és 2015-ben történt meg a restaurálása. A tárlaton Serédy Zsófia múmiája egy 1 millió magyar forintot érő Boris Hanečka által tervezett fekete ruhát viselt. A rendezvényt a magyar és a szlovák sajtó egyaránt nagy érdeklődéssel követte végig.

Jegyzetek

Az 1600-as években született személyek
1710-ben elhunyt személyek

redpajama_set_name: RedPajamaWikipedia


text:
Q: conda create environment ResolvePackageNotFound when pip is successful I am trying to create a conda environment using the following environment.yml file:
conda env create -n med -f environment.yml

File contents:
name: med

channels:
  - defaults
  - conda-forge

dependencies:
  - python=3.8
  - batchgenerators==0.23
  - pandas==1.1.5
  - SimpleITK==2.2.1
  - tensorboard==2.11.0
  - tqdm
  - pip
  - pip:
    - --extra-index-url https://download.pytorch.org/whl/cu117
    - torch==1.13.1+cu117
    - torchvision==0.14.1+cu117

The setup fails with:
ResolvePackageNotFound:

- batchgenerators

If I delete batchgenerators from the yml file, create the environment, conda activate it and try pip install batchgenerators - it is successful.
Further, using pip also works
conda create -n med
conda activate med
pip install -r requirements.txt

batchgenerators==0.23
pandas==1.1.5
SimpleITK==2.2.1
tensorboard==2.11.0
torch==1.13.1+cu117
torchvision==0.14.1+cu117
tqdm

Any suggestions to make conda work directly?
Thanks,
Bogdan

A: Thanks to @griko! Adding batchgenerators to the yml file fixed the issue because the package is available on pypi but not in conda defaults or conda forge.
- pip:
  - --extra-index-url https://download.pytorch.org/whl/cu117
  - torch==1.13.1+cu117
  - torchvision==0.14.1+cu117
  - batchgenerators==0.23


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1500 Ocean Drive is an unmistakable oceanfront condominium referred to as the Michael Graves building. 1500 Ocean Drive sits on world-renown Ocean Drive in South Beach.
Total Units: 112 Units from 940 to 4640 sq. ft.


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