text:
LEADING NETWORK MANAGEMENT SYSTEM SUPPLIER TO TOP MINING OEM'S COMPLETES RAJANT INTEGRATION
FTP Solutions Integrated Management System Choice for Top Autonomy OEMs
June 02, 2021 07:00 ET | Source: Rajant Corporation Rajant Corporation
Malvern, Pennsylvania, UNITED STATES
Malvern, Pennsylvania (USA), June 02, 2021 (GLOBE NEWSWIRE) -- Rajant Corporation, the Kinetic Mesh® wireless network provider, has collaborated to complete the implementation of the Integrated Management System (IMS) by FTP Solutions, the leading network management system (NMS) supplier to top mining OEMs.
According to Scott Mills, FTP Technical Director and the person who built IMS, "FTP partnered with Rajant to incorporate its BreadCrumb radios into our IMS platform because Rajant technology is the most dependable and reliable network for mission-critical applications like autonomy, according to our customers. The mining operator benefits from a leading fit-for-purpose radio coupled with a single-pane-of-glass monitoring system. The deep integration of the FTP IMS platform with Rajant Kinetic Mesh makes possible previously unattainable visibility into the high level of performance that a Rajant network enables at a mine."
"Rajant's leading industrial wireless M2M radios provide site-wide connectivity regardless of layout and terrain, giving mining operators peace of mind for mission-critical connectivity. FTP's IMS visualization of data from multiple systems combined with Rajant networking provides a reliable holistic view of operational data," adds FTP Co-founder and Managing Director Lachlan McMahon. "FTP has unlocked the ability to view an entire operation through a single-pane-of-glass, and all stakeholders across the mining organization can visualize the performance and are connected by a data assurance network that Rajant technology provides."
"FTP is in the forefront of reporting network health for the entire OT mining network, and they do it in an agnostic way when it comes to radio technologies including Rajant, LTE, and Wi-Fi, " says Rajant EVP of Global Sales and Marketing Geoff Smith. "FTP's IMS platform reports on the health of the entire mine network to all relevant parties, which is critical when it comes to having a truly automated operation. Rajant technology can work with any backhaul, including LTE, to provide seamless connectivity through a mine site regardless of pre-existing infrastructure. Further, our industrial wireless networking is both forwards and backhaul compatible, maintaining a mine's investment and with easing upgrades to the latest technology like our latest Peregrine and Hawk platforms."
About FTP Solutions
FTP Solutions is an innovative company dedicated to designing, installing, and supporting critical operational wireless networks. Through our in-depth knowledge of wireless and fixed networks, FTP built the wireless network monitoring platform known as the Integrated Management System (IMS). This software has been designed from the ground up with the network maintainer in mind. For more information, visit www.ftpsolutions.com.au.
About Rajant Corporation
Rajant Corporation is the broadband communications technology company that invented Kinetic Mesh® networking, BreadCrumb® wireless nodes, and InstaMesh® networking software. With Rajant, customers can rapidly deploy a highly adaptable and scalable network that leverages the power of real-time data to deliver on-demand, mission-critical business intelligence. A low-latency, high-throughput, and secure solution for a variety of data, voice, video, and autonomous applications, Rajant's Kinetic Mesh networks provide industrial customers with full mobility, allowing them to take their private network applications and data anywhere. With successful deployments in more than 60 countries for customers in military, mining, ports, rail, oil & gas, petrochemical plants, municipalities, and agriculture. Rajant is headquartered in Malvern, Pennsylvania with additional facilities and offices in Arizona and Kentucky. For more information, visit Rajant.com or follow Rajant on LinkedIn and Twitter.
FTP Solutions colour logo
FTP Solutions is an innovative company dedicated to designing, installing, and supporting critical o...
Rajant FTP Kinetic Mesh Mining wireless networking
Rajant Corporation
Rajant LinkedIn Company Page
Rajant Twitter
FTP Solutions
Alice DiSanto
adisanto@rajant.com
With a Reader Account, it's easy to send email directly to the contact for this release. Sign up today for your free Reader Account!


The Trump-Sessions policy of separating children from their parents at our southern border has come back to haunt Mr. Trump.
His daughter, Ivanka, the most sensible of all five Trump children, has spoken out forcefully against that policy, calling it the lowest point in her father's time in the White House (https://www.npr.org/2018/08/02/634898041/ivanka-trump-family-separations-were-a-low-point).
Associate solitary reporters Johanna Jones and Keith Coleman were with Mr. Trump when he learned about Ivanka's criticism.
For once, Jared Kushner, Ivanka's husband, was not in Jerusalem exchanging high fives with Benjamin Netanyahu.
"Yes?" Jared said, as he entered the Oval Office apprehensively.
Then, all hell broke loose as Trump tried to throw his son-in-law out the window onto the White House lawn.
But Kushner, 37, is in much better shape than his 72-year old, 239 pound father-in-law.
The Secret Service had to restrain Kushner.
After Secret Service Director Randy Ailes led Kushner onto Pennsylvania Avenue, Trump called his Treasury Secretary, Steve Mnuchin, a Wall Street guy through and through. Mnuchin has been tasked to see if the big big tax break that Trump wants to dole out, to his super-wealthy buddies, can be done by a stroke of Trump's or Mnuchin's pen, rather than going through Congress, an institution that Trump barely tolerates (https://www.politico.com/story/2018/08/01/trump-treasury-capital-gains-tax-cut-756945).
"No can do, Sir," Mnuchin told Trump.
Mnuchin smiled and said, "Absolutely, Keith, that's exactly what I'm gonna do."


(Press Release) The Bishop Police Department would like to make the public aware of a phone scam circling the Bishop area. We have received reports advising the police department that local residents are receiving phone calls from a Medicare representative. A heavy accented speaking male subject tells the caller he is from Medicare and needs the name of the bank they use. If asked why, the representative continues by saying he needs the name of the bank and the banks routing number or else the Medicare card will be cancelled. If you hang up the phone, they try again to call back and use scare tactics in order to obtain the bank information.
The number the "representative" calls from is no good and you cannot call back. The Bishop Police Department recommends that if you receive this type of call, to never provide any of your personal information over the phone and if you have any concerns regarding your Medicare card to contact the company yourself. There is a number provided on the front of the Medicare card.
There are phone scams occurring in our small area, so please protect your information and never give your information over the phone.
It would be nice if these jerks would stop preying on these seniors.
I think we need to be able to trace these calls without police intervention.
If I were to ever find one of these jerks I would tie them up and tow them around on the back of my truck in front of all the folks they scammed.
then I would remove their voice box so they cannot make another call.
So once you've traced the call to India what are you going to do?


text:
Södermanlands runinskrifter 284 är ett runstensfragment som sitter inmurad i norra kyrkomuren i Botkyrka kyrka. Vid kyrkan återfinns även runstenarna Sö 283, Sö 285 och Sö 286 (det så kallade Botkyrkamonumentet). Runstenen Sö 282 fanns tidigare vid kyrkan, men är nu förkommen.

Stenen
Runstensfragmentet är av röd sandsten och sitter inmurat i kyrkans norra mur till höger om sakristian, nära taket. Det är omkring en meter långt och 0,58 meter brett. Ristningen är mycket skadad, och en ankarslut sitter mitt på stenen och skymmer den delvis. Ristningen är imålad.

Inskrift
Inskriften lyder i translitterering:
...(u)na + bruþu : ---...

Normaliserat till runsvenska:
-una, broðu[r]

Eftersom inskriften är så fragmentarisk är den svårtydd, men det sista ordet är säkerligen "broder".

Se även
Lista över Södermanlands runinskrifter

Källor

Noter

Södermanlands runinskrifter
Runinskrifter i Botkyrka kommun

redpajama_set_name: RedPajamaWikipedia


text:
13 things you should never put in a garbage disposal
Although useful, garbage disposals can't process everything. Here is what to avoid
(Image credit: Getty Images)
By Chiana Dickson
Easily one of the most convenient additions to a modern kitchen, a garbage disposal can make a kitchen clean up 10 times faster. However, it is possible to put the wrong things down it and clog up the mechanism.
Unclogging a garbage disposal is no one's favorite home maintenance task, so learning what you can and cannot throw into yours is the first step in making sure your appliance continues to work as promised, with very few hiccups along the way.
Here, we have rounded up 13 things you should avoid putting in your garbage disposal to keep it running like new.
Not everything can go into a garbage disposal, though if you have mistakenly put something down there that shouldn't be, all is not, necessarily, lost.
'Even the most powerful disposal has limits to what it can handle,' says Steve Moore of North Carolina-based Moore Appliance Service (opens in new tab). Steve goes on to advise using 'cold water when running your disposal. Hot water can cause fats to congeal more easily. Be sure to run the water for at least 15 seconds after turning off the disposal. This will ensure that food particles are flushed down the drain.'
Steve also advises cleaning the disposal 'every two weeks by processing a small amount of ice. The blades will cleanse themselves by slicing through the hard ice before it melts away.'
1. Leftover cooking fat and grease
Cleaning grease and getting rid of cooking fat isn't easy, and unfortunately, it is not as simple as putting them down the garbage disposal either. Once cooled, fat and grease can clog up a garbage disposal, sometimes to the point of it needing professional maintenance.
Rather than pouring it down the sink or garbage disposal, allow it to solidify before scraping it into the trash, or combine it with lard and suet to make fat balls for the birds in your yard.
Master Plunger MP100-3 – Was $16.92, now $15.50 at Amazon (opens in new tab)
If your waste disposal does become clogged, turning it off and using a plunger to shift the blockage is the best start to get things moving again.
2. Coffee grounds
Coffee grounds can cause some serious damage to your garbage disposal system. Grounds can form a thick paste when wet or ground for too long, causing blockages in garbage disposal units.
Instead, consider using coffee grounds for plants as a high-nitrogen fertilizer, or as a deterrent in a vegetable garden against slugs and snails.
3. Dry expandable foods such as pasta and rice
(Image credit: Unsplash)
Although dried goods like pasta, oats, and rice may break down easily in a garbage disposal, they are prone to expanding once wet. With liquid getting into your disposal most days, these small, unsuspecting grains can rapidly build up, expand, and cause a foul-smelling blockage.
Of course, they will be okay in small quantities, such as a few leftovers from dinner, but fuller portions should be scrapped into your trash can first.
4. Stickers from produce
(Image credit: Alamy)
Although many forms of soft fruits and vegetables can be disposed of in a garbage disposal, the small produce stickers on the peels cannot. These small labels are often non-biodegradable meaning they will not break down.
Often, they are non-recyclable too, so the only solution is to throw them into your general household waste, making sure to put the peels themselves into compost.
5. Fibrous or stringy fruits and veggies – like asparagus or celery
(Image credit: Asparagus mondeo from Thompson & Morgan)
Particularly stringy or fibrous foods such as asparagus, rhubarb, and celery can be had for our teeth to pull apart, and are just as difficult for a garbage disposal to take care of too.
The long fibers of these vegetables usually end up tangled around the components of a waste disposal and are almost impossible to remove when cleaning a garbage disposal. Throw these leftovers onto a compost heap or even into a countertop compost bin whenever possible.
Lomi: The Smart Waste Kitchen Composter – $499.99 at Amazon (opens in new tab)
Lomi is a countertop kitchen composter that breaks down organic waste such as food scraps to be used as either soil, mixed with existing compost, or tossed into your green bin with other compostable materials.
6. Eggshells
Although thought to help 'sharpen' a garbage disposal, the membrane on the inside of an egg shell can easily wrap itself around the mechanism and be just as impossible to remove as fibrous fruits and vegetables.
Egg shells are easy to dispose of, however, as you can use eggs in the garden for a range of applications such as fertilizer and pest deterrent; and they are also fully compostable, making a great addition to any garden compost bin.
Looking to sharpen your garbage disposal? You might want to use ice to clean your garbage disposal and freshen up the blades instead.
7. Bones, even smaller fish bones
(Image credit: Future/Emma Lee)
Bones are tough, and that should be of no surprise to anyone. It is to be expected, therefore, that bones from food can cause havoc in a garbage disposal system. All bones, no matter their size, should be thrown in the general trash.
While smaller bones are less likely to cause damage than larger ones, it is safer to avoid them all to keep your disposal in great shape.
8. Tough chicken skin or meat fat
(Image credit: Jonathan Gregson)
Although soft, the skin and fatty rind from meats such as pork and chicken not only stick to the inside of garbage disposals but smell horrendous after a while, too, making them a poor addition to a disposal unit.
As with bones, all waste products such as skin and fat from meat should go into your household waste.
9. General household trash
(Image credit: Naked Kitchens)
You would be surprised at how often repairmen are faced with a garbage disposal unit that has been clogged or broken by household junk. Even things that should never have been in a kitchen in the first place!
Things such as paper towels, wrappers, bags, and so on should always go into a general waste, with garbage disposals saved for soft fruits, vegetables, and liquids.
10. Vegetable peels such as onion and potato skins
Thin vegetable peelings from onions, carrots, and potatoes are often small enough to slide between the disposal grinders, filling up the pipes and causing blockages that can be hard to get rid of.
As with any organic waste, peels are fully compostable. If you are looking for something more exciting to use potato peels for, however, then saving them for crispy stuffed potato skins, or even using them to make your own vegetable stock is a great, no-waste alternative.
11. Nuts and larger seeds
Nuts, seeds, and fruit pits are some of the most common causes of garbage disposal malfunctions, with their seriously tough exteriors breaking the grinding components with ease. If you want to avoid replacing your unit, add seeds, pits, and old nuts into compost, leave them outside for the birds, or throw them in your general trash.
A good rule of thumb to follow with waste disposals is to ask yourself 'can I cut this easily with a knife?' If not, then your garbage disposal likely won't be able to manage it either.
12. Harsh chemicals such as bleach
We usually turn to harsh chemicals such as bleach to unblock drains and clean our homes, but excessive amounts of these liquids can cause wear on your disposal and significantly shorten its lifespan.
We are not talking about your everyday dish soap here, of course, but things like bleach and commercial drain cleaners. To clean your waste disposal, consider using non-chemical methods such as ice cubes first.
13. Shells from seafood
Hard outer shells from seafood like oysters, lobster, shrimp, and crab are too dense to pass through a disposal unit, either damaging the grinders or creating immovable blockages rendering your disposal nearly useless.
Given the strong smells that come from waste such as this, dropping them into a small bag and getting rid of them in your external waste is the best course of action to save your garbage disposal and save your kitchen from acrid lingering smells.
What can you put in a garbage disposal?
While there are a lot of foods you should avoid putting in a garbage disposal, foods such as soft fruits and vegetables and non-hardening liquids can safely be put in a garbage disposal without damaging the machine or causing blockages – especially when the garbage disposal is cleaned correctly too.
How do I keep my garbage disposal healthy?
To keep a garbage disposal clean and in good condition, you should clean it out once a week. Making cleaning a garbage disposal a part of your weekly kitchen cleaning routine will help to prevent blockages and keep the components in good condition so they are less likely to need replacing as quickly.
Chiana Dickson
Junior Writer
Chiana is a junior writer for Homes & Gardens having joined Future plc as a new graduate in 2022 after achieving a 1st class degree in Literature at university. She first became interested in design as a child after spending her summers helping her parents redecorate her childhood home. As a long-time reader of Future's homes titles, Chiana is constantly finding new inspiration at work as she focuses on emerging trends, how-to's, and news pieces.
Knowing how to repot a bird of paradise will keep these houseplants in top condition – and may encourage a flower or two
Give your strelitzia a new home with these simple steps – but only when the time is right
By Holly Crossley • Published 1 February 23

redpajama_set_name: RedPajamaCommonCrawl


text:
International Laboratory Network
LABORATORIES LABORATORIES
Harnessing Gravity for Drinking Cleaner Water?
Oman's Sultan Qaboos University has become a hotspot for mind-blowing scientific ideas and scientific interaction since the opening of the 4th Science and Technology Exchange Program (STEP) in Islamic Countries on Sunday. High on the agenda is ways to tackle water shortage.
MSTF Media reports:
In the session themed 'Water and Wastewater: Challenges and Solutions', scientists presented papers on their findings.
Adel Sharif, Chair in Water Engineering and Process Innovation, University of Surrey was excited to share his views on new trends in water management, "STEP is a brilliant idea. I am very pleased to be here. Addressing critical issues of water, energy, health and food is very important to the world and especially to the region as it is critical," said Sharif, after speaking in the panel.
Today, governments are concerned with the sustainable supply of water as a critical step towards sustainable development. "The major source we are certain about is the sea. Finding a cheaper way for producing clean water from the sea would be the ultimate solution," said Adel Sharif. That's what exactly Sharif and his team are working on at the University of Surrey.
"We are working on how to make desalinated sea water more energy efficient and cheaper in terms of capital and energy cost. For obvious reasons, we cannot rely on fossil fuel because of its challenges. Renewable sources also have some constraints in terms of cost, availability and reliability; we turned to ultimate source of energy that has very little or no constraints geographically or climatically and that is GRAVITY," pointed out the scientist.
Employing gravity in producing clean water and power could revolutionize the water industry. Sharif says it takes time and effort, but it's "not impossible".
"If you asked a human a few yew years ago about mobile technology, he would have labeled it as magic. If you were to describe a plane a few 100 years ago they would have said the same thing – magic. So man has always made things possible that was not available in the previous generations. So do not be surprised if we are able to harness gravity for power generation. Believe it would be less complex than iPhone and airplane. This would be my contribution to the young and future generation," he said.
Sharif would like to bring it to the world as soon as they get enough support to make it happening as of now the technical details are confidential.
He hailed Mustafa (pbuh) Science and Technology Foundation and Sultan Qaboos University for organizing STEP and providing a chance for scientists from the Islamic world to come together and network for a better scientific future.
LABORATOIES
© Intlabsnet.com - All Right Reserved.


text:
Court to rule May 21 whether to dismiss Steven Salaita case
Will American Assoc. of University Profs wait for Court ruling before deciding whether to censure U. Illinois?
Posted by William A. Jacobson Tuesday, March 10, 2015 at 07:00pm 2 Comments
The Trustees and senior officers of the University of Illinois, who are defendants in the federal lawsuit by Steven Salaita, filed a motion to dismiss the case on February 24. Salaita, you will recall, had tweeting issues, to put it mildly.
At a court hearing today, the Judge set down a briefing schedule, with Salaita's attorneys having until March 30 to respond, and the defendant's attorneys until April 20 to reply.
The Court set May 21 as the date it would rule, orally in court. (Order at bottom.)
That's a little unusual in my experience. Normally a judge would issue a written opinion on such a law-heavy motion. I can't tell you whether to read anything into that; it could be that judge's practice, or the judge may orally issue an order and then refer people to a written opinion.
The court did order the parties to propose a discovery plan, meaning the exchange of documents, depositions, and so on. The submission of such plans is required under the federal and court rules. It is likely that some discovery will take place prior to the ruling on the motion to dismiss under such plan.
I can't tell you whether the judge allowing discovery to commence reflects on the likelihood of the outcome of the motion to dismiss.
In their motion requesting that the Court order the defendants to confer on a discovery plan, Salaita's attorneys pointed out that there is no presumption of a stay of discovery pending resolution of a motion to dismiss. The PACER electronic docket does not reflect any opposition by the Trustees counsel having been filed as to the commencement of discovery.
If I see any reports whether the Judge expressed any view during the hearing, I'll update.
There is significance, though, to the timing, unrelated to the lawsuit itself.
The American Association of University Professors is in the process of deciding whether to censure the University of Illinois for "firing" Salaita without giving him the benefit of procedural protections for firing a tenured professor, and a decision is expected by late May.
The university and its Trustees say — I believe correctly — that Salaita never was fired and never was tenured because he never was hired. It was a contingent offer and the contingency (Board of Trustees approval) never happened.
There never was a promise upon which Salaita reasonably could have relied that the contingency was waived, a glaring defect I immediately picked up on when initially reading the complaint, as did the defendants' counsel in the motion to dismiss. Whether the court agrees we will find out on May 21.
If the court rules on this contract issue in favor of the Trustees, that would take the foundation out of the AAUP censure. There are other claims in the case, including alleged violation of the First Amendment, but the "firing" without due process has been foundation of the AAUP's consideration of censure, to the extent there has been public disclosure.
2	2 Comments Steven Salaita
Steven Salaita
Valerie | March 10, 2015 at 10:11 pm
Allowing discovery during a pending motion to dismiss can short-circuit a plaintiff's argument that discovery would (or might) have yielded evidence crucial to the plaintiff's case. Further, this action discourages the filing of a motion to dismiss as a tactic to delay trial and run up the costs of trial, especially where there is an imbalance of funding, as there presumably is when an individual sues an institution.
If I were a judge, and looking for ways to make a likely order dismissing a political cause célèbre bombproof, that is what I would do. Then, in my opinion, I might note that plaintiff has already had discovery, and has not amended the complaint.
innocent bystander | March 11, 2015 at 8:48 pm
Of course, the case is dismissed.
Now, a few predictions: The dept's new faculty position disappears. None of the assistant or associate prof's in the dept's core faculty are promoted for at least 5 years, which means at least two leave. They are not replaced.


Folks have tried to recreate parts of New York City elsewhere (remember the "East Village" planned for Las Vegas?), but an NYC-at-sea is definitely a new concept. Royal Caribbean is currently building a massive new cruise ship called Oasis of the Seas in Finland, and the future world's largest ocean liner may look a little familiar to New Yorkers. Or...maybe not. While the 28 "New York-style" duplex loft suites certainly have a new-development vibe to them, the ship's "Central Park" and Coney Island-inspired "Boardwalk" probably won't be mistaken for the originals in a line-up. The cruise ship versions do have their advantages, however: buffets and slot machines are never more than a few steps away, which is more than we can say for this calorie-counting, puritanical prison of a town!


text:
Does Simon Rattle's Sibelius set outshine his previous best?
It's my album of the week on sinfinimusic.com, and there's a lot to beat out there:
The set faces testing competition, starting with Rattle's 1990s Birmingham cycle for EMI-Warner and Herbert von Karajan's 1970s Berlin cycle for DG. In one important respect, there is no comparison: for tonal beauty and playing skill, this set outshines the other two by a factor of laser to gaslight.
The current Berlin Philharmonic are a crack ensemble who deliver precision music making at high power. Birmingham sounds stressed in contrast and Karajan's Berliners cautious. The playing here is massively impressive, almost overwhelming on the open roads of the Second Symphony. Not much can beat the sensual pleasure of listening to this kind of aural perfection.
« Music producer is shot dead in Brooklyn, near BAM
Orchestra destroyer is named head of arts channel »
Norman, there is no HvK DG cycle from the 70s. He did the last four symphonies for DG at the Jesus-Christus-Kirche in 1965 and 1967 (indispensable readings) and the first two for EMI in 1981 and 1980. He had also recorded the 2nd and last four for Columbia between 1951 and 1960, and he redid the 5th and 6th for EMI in 1976 and 1980. That's all, except for a handful of concert air-checks.
harold braun says:
And for whatever reason,HvK sadly never performed the 3rd
NYMike says:
Vänskä's interrupted set with the Minnesota Orchestra, now to be completed post-lockout will be something to reckon with. Their pre-lockout 1st and 4th CD won a Grammy.
Pamela Brown says:
Really! With all due respect, Mr. Lebrecht, what is the MO — chopped liver? :-0
Milka says:
sinfinimusic ? let's be serious for a change
Holger H. says:
Comparison, the root of all mischief on this planet.
Vänskä & Lahti.
Why even try to act as if you ever had to listen to another set?
As a big Sibelius fan who owns hundreds of recordings of his music,
Rattle's BPO Sibelius just sounds boring to me.
The early Karajan and Kamu recordings are fine too but nothing compares to the Lahti set.
Certainly not Rattle's earlier or newer set.
The MPO sounds pretty good too, again with Vänskä.
Why can't we all just agree, if you need to listen to Sibelius, go to Vänskä. It's what he does. 🙂
(obviously NOT the MPO, but MO).


text:
Tony Kanaan looks toward 2021 with eye on driving, media and coaching
By Nate RyanSep 1, 2020, 12:00 PM EDT
Brian Spurlock-USA TODAY Sports
Tony Kanaan doesn't think he has started his last NTT IndyCar Series race, but he also knows the decision on what's next isn't entirely up to him.
"I want to come back, but that doesn't mean anything," Kanaan said Saturday before qualifying at World Wide Technology Raceway at Gateway. "Me wanting something doesn't mean that's what is going to happen. I still have to find a car and find a sponsor.
"I'll have the whole winter toward finding a ride and a sponsor that might give me a chance to run again. If not, I'm OK with it. I had an awesome run."
The 2004 series champion and 2013 Indianapolis 500 winner treated a 19th-place finish Sunday as if his 383rd start were the finale of a 23-year run as an IndyCar driver.
Thank you guys. It has been a amazing journey. Love you all https://t.co/42lT2mdrNr
— Tony Kanaan (@TonyKanaan) August 30, 2020
With 17 victories and 15 pole positions in 383 starts (ranking second all time to Mario Andretti's 407), Kanaan isn't ready to say goodbye after hardly getting the chance during his "Last Lap" season that was marred by the novel coronavirus (COVID-19) pandemic.
"I definitely want to come back after a weird year for all of us, so it's going to take a lot of work, which I don't mind," Kanaan said last month on Indy 500 qualifying weekend. "I've done it before. I'm going to regroup with my sponsors to see what we can come up with. I'm probably in a good position if I can gather the funds and say, 'All right, where am I going to go?' "
Tony Kanaan jokingly tried to fit a mask last month on his sculpted bust from his 2013 Indy 500 victory on the Borg-Warner Trophy, which he also outfitted with its own mask (Photos by Brian Spurlock-USA TODAY Sports).
(Brian Spurlock-USA TODAY Sports)
Kanaan expects to spend the next two months knocking on doors to cobble together a budget that he then can shop to teams for at least racing in the 105th Indy 500 in May. The meetings about his '21 prospects began this week.
"I have not talked to any teams yet," he said. "I think the best approach was going to be let's see what kind of money I can raise, then I can go talk to the teams. I think all my sponsors are on board as far as wanting to talk to see what extent they can do something, if they can do something. The next two weeks I probably will know something, then we'll start talking. But we'll see. It's going to be really hard."
His goals are flexible – anywhere from a one-off Indy 500 start to the five ovals he had planned to run in '20. He is "100 percent certain" it won't be a full season.
The primary objective is a proper farewell that will allow the interaction with fans that the popular Brazilian was robbed of enjoying during this star-crossed season, which also saw the end of his record streak of 318 consecutive starts.
"We had so many plans to do it with the fans," he said. "I hinted at (racing in 2021) and got bombarded by my fans that I need to do this, so the response was pretty cool."
Tony Kanaan prepares to race the No. 14 Dallara-Chevrolet at World Wide Technology Raceway last weekend, his final starts of the 2020 IndyCar season (James Black/IndyCar).
His ideal schedule would be at least 10 races – five in IndyCar, plus the inaugural season in the Superstar Racing Experience series started by Ray Evenrham and Tony Stewart. Kanaan signed a letter of intent in mid-August with the series and jokes "there is life beyond IndyCar!" – and it might not be behind the wheel. He has plans to branch out into media (he has dabbled in Indy Lights broadcasting).
"I have a lot of talks to do some commentary and podcasts," Kanaan said. "That would be something I'd be really interested in doing. I'm not the type of a guy who says I need the time off."
He is intrigued by the idea of coaching two or three up and comers in the IndyCar ladder series — as he already was a natural mentor for teammates throughout his career.
"I've done that all my life literally in IndyCar," said Kanaan, whose legendary dedication to workouts and ease with interviews provide a good foundaiton for teaching the rigors of a driver's life off the track. "And I could help these kids, not just on the driving side, but to tell them, 'This is how you should behave with the media. This is how to treat sponsors. You're going to work your ass off every morning like I did.' Just guide the kids. I haven't talked to anybody, and I don't have a kid in mind, but I have plenty of time to look at the ladder series of IndyCar. That's something I'd love to do."
But of course, he'd love nothing more than to race again in IndyCar, too, particularly after feeling good about his six starts in 2020 with A.J. Foyt Racing. He was a season-best ninth Saturday at Gateway and was contending for a top 10 in the Indy 500 before a miscue on his last pit stop.
"It was a very consistent season, if I can call that a season," he said. ""It was nothing like I had planned. I had a lot of plans to enjoy with the sponsors, the fans, everybody else. I would say the highlight was just to be a part of it. I had a good run. I made good friends."
This is @TonyKanaan's last confirmed start in the @IndyCar series.
Before he went off to race, his teammates went to congratulate him on a legendary career. #TKLastLap #INDYCAR pic.twitter.com/iM8IWvT4vl
— IndyCar on NBC (@IndyCaronNBC) August 30, 2020
That was evident by the receiving line of team members and drivers who greeted Kanaan before what could be his final start.
"It was weird, man," Kanaan said. "I mean, it was really tough. I wasn't expecting that. I think I kind of had forgotten without the fans, I thought it was going to be a lot easier because there would be less people.
"It was tough. Especially when you have the adrenaline kicking in right before the race. You try to concentrate. I obviously got extremely emotional. But it's nice. I didn't expect that. I didn't plan it. It was really cool."


text:
Pendergrass Charged with Murder of Missing Girlfriend
Desmond Laquan Pendergrass
"GREENSBORO, NC (Sept. 2, 2016) –Greensboro police arrested a local man yesterday and charged him with First Degree Murder in connection with the disappearance of his missing 26-year-old girlfriend.
Desmond Laquan Pendergrass, 25, was taken into police custody yesterday morning at his High Point residence and charged with the murder of Cree Asia Smith who was reported missing by family members on July 12, 2016.
According to witnesses, Smith was last seen on June 16, 2016 at 2C Huntley Court where she and Pendergrass resided at the time.
Detectives learned that the couple was involved in a domestic dispute immediately before she went missing. Because her disappearance was under suspicious circumstances, Crime Stoppers issued a Missing Person alert for Smith on July 15.
Smith's body has not yet been found. However, detectives established sufficient evidence through interviews and forensics to charge Pendergrass with her murder.
Police are continuing to investigate, and hope to find her remains in order to bring some closure to her friends and family.
Pendergrass is confined in the Greensboro Jail Central without bond."


text:
\section*{Introduction}

Fragment-based quantum mechanical methods \cite{Otto1975,Gao1997,GEBF,EEMB,SMF,KEM,Ryde2010,MTA,ELG,DC,XO-ONIOM,MFCC-D} are becoming increasingly popular\cite{gordon2012fragmentation}, and have been used to describe a very diverse set of molecular properties for large systems. Although these methods have been applied to refine the energetics of some enzymatic reactions\cite{ishida2006all,nemukhin2012} they are usually not efficient enough to allow for many hundreds of single point calculations needed to map out a reaction path for a system containing thousands of atoms, although geometry optimizations of large systems can be performed for systems consisting of several hundreds of atoms \cite{XO-ONIOM,MTA,ELG,FMOopt,FMOMP2_PCM,fedorov2011geometry}. In fact, typically applications of fragment-based methods to biochemical systems, for example, to protein-ligand binding \cite{Sawada}, are based on performing a few single point calculations for structures obtained at a lower level of theory (such as with force fields). Although many force fields are well tuned to treat typical proteins, for ligands they can be problematic.

In this work we extend the effective fragment molecular orbital (EFMO) method\cite{steinmann2010effective,steinmann2012effective}
into the frozen domain (FD) formalism \cite{fedorov2011geometry}, originally developed for the fragment molecular orbital (FMO) method \cite {FMO1,FMOrev1,FMObook,FMOrev2}. For FMO, there is also partial energy gradient method \cite{PEG}.

EFMO is based on dividing a large molecular system into fragments and performing ab initio calculations of fragments and their pairs, and combining their energies in the energy of the whole system (see more below). In the FD approach we employ here, one defines an active region associated with the active site, and the cost of a geometry optimization is then essentially given by the cost associated with the active region.

However, unlike the quantum-mechanical / molecular mechanical (QM/MM) method \cite{MD-rev4} with non-polarizable force fields, the polarization of the whole
system is accounted for in FMO and EFMO methods: in the former via the explicit polarizing potential and in the latter via
fragment polarizabilities. Another important difference between EFMO and QM/MM is that the former does not involve force fields, and
the need to elaborately determine parameters for ligands does not exist in EFMO. Also, in EFMO all fragments are treated with quantum mechanics,
and the problem of the active site size \cite{Ryde} does not arise.

The paper is organized as follows: First, we derive the EFMO energy and gradient expressions for the frozen domain approach, when some part of the system is frozen during the geometry optimization. Secondly, we predict the reaction barrier of barrier of the conversion of chorismate to prephenate (Figure~\ref{fig:chorismate}) in chorismate mutase. The reaction has been studied previously using conventional QM/MM techniques \cite{lyne1995insights,davidson1996mechanism,hall2000aspects,marti2001transition,worthington2001md,lee2002reaction,lee2003exploring,ranaghan2003insights,ranaghan2004transition,friesner2005ab,crespo2005multiple,claeyssens2011analysis}. The EFMO method is similar in spirit to QM/MM in using a cheap model for the less important part of the system and the mapping is accomplished with a reasonable amount of computational resources (four days per reaction path using 80 CPU cores). Finally we summarize our results and discuss future directions.

\section*{Background and Theory}
The EFMO energy of a system of $N$ fragments (monomers) is
\begin{equation}
E^\mathrm{EFMO} = \sum_I^N E_I^0 + \sum_{IJ}^{R_{I,J}\leq R_\mathrm{resdim}} \left( \Delta E_{IJ}^0 - E_{IJ}^\mathrm{POL} \right) + \sum_{IJ}^{R_{I,J} > R_\mathrm{resdim}} E_{IJ}^\mathrm{ES} + E_\mathrm{tot}^\mathrm{POL}
\label{eqn:efmoenergy}
\end{equation}
where $E_I^0$ is the gas phase energy of monomer $I$. The second sum in equation~\ref{eqn:efmoenergy} is the pairwise correction to the monomer energy and only applies for pairs of fragments (dimers) separated by an interfragment distance $R_{I,J}$ (defined previously \cite{steinmann2010effective}) less than a threshold $R_\mathrm{resdim}$. The correction for dimer $IJ$ is
\begin{equation}
\Delta E_{IJ}^0 = E_{IJ}^0 - E^0_I - E^0_J.
\end{equation}
$E_{IJ}^\mathrm{POL}$ and $E_\mathrm{tot}^\mathrm{POL}$ are the classical pair polarization energy of dimer $IJ$ and the classical total polarization energy, respectively. Both energies are evaluated using the induced dipole model\cite{day1996effective,gordon2001effective} based on distributed polarizabilities\cite{minikis2001accurate}. The final sum over $E_{IJ}^\mathrm{ES}$ is the classical electrostatic interaction energy and applies only to dimers separated by a distance greater than $R_\mathrm{resdim}$. These energies are evaluated using atom-centered multipole moments through quadrupoles\cite{stone1981distributed}. The multipole moments and distributed polarizabilities are computed on the fly for each fragment\cite{steinmann2010effective,steinmann2012effective}.

In cases where only part of a molecular system is to be optimized by minimizing the energy, equation~\ref{eqn:efmoenergy} can be rewritten, resulting in a method conceptually overlapping with QM/MM in using a cheap model for the less important part of the system. Consider a system $S$ (Figure~\ref{fig:active}) where we wish to optimize the positions of atoms in region $A$, while keeping the atoms in region $b$ and $F$ frozen (the difference between $b$ and $F$ will be discussed below). With this definition, we rewrite the EFMO energy as
\begin{equation} \label{eqn:energyregion}
E^\mathrm{EFMO} = E^0_F + E^0_b + E^0_A + E^0_{F/b} + E^0_{F/A} +E^0_{A/b} + E_\mathrm{tot}^\mathrm{POL},
\end{equation}
where $E^0_A$ is the internal energy of region $A$. Region $A$ is made of fragments contaning atoms whose position is optimized,
and $A$ can also have some frozen atoms
\begin{equation}
E^0_A = \sum_{I\in A}^N E_I^0 + \sum_{{I,J\in A}}^{R_{I,J}\leq R_\mathrm{resdim}} \left( \Delta E_{IJ}^0 - E_{IJ}^\mathrm{POL} \right) + \sum_{{I,J\in A}}^{R_{I,J} > R_\mathrm{resdim}} E_{IJ}^\mathrm{ES}.
\end{equation}
Similarly, $E^0_b$ is the internal energy of $b$
\begin{equation} \label{eqn:regionbenergy}
E^0_b = \sum_{I\in b}^N E_I^0 + \sum_{{I,J\in b}}^{R_{I,J}\leq R_\mathrm{resdim}} \left( \Delta E_{IJ}^0 - E_{IJ}^\mathrm{POL} \right) + \sum_{{I,J\in b}}^{R_{I,J} > R_\mathrm{resdim}} E_{IJ}^\mathrm{ES},
\end{equation}
Region $A$ is surrounded by a buffer $b$, because fragment pairs computed with QM containing one fragment outside of $A$ (i.e., in $b$) can still contribute to the total energy gradient (see below). On the other hand, fragment pairs with one fragment in $F$ can also
contribute to the total gradient, but they are computed using a simple classical expression rather than with QM.
Note that the relation between the notation used in FMO/FD and that we use here is as follows: $A,F$ and $S$ are the same. The buffer region $B$ includes $A$, but $b$ does not, i.e., $A$ and $b$ share no atoms. Formally, $A$ and $b$ are always treated at the same level of theory by assigning fragments to the same layer.

{\color{black}In the EFMO method, covalent bonds between fragments are not cut. Instead, electrons from a bond connecting two fragments are placed entirely to one of the fragments. The electrons of the fragments are kept in place by using frozen orbitals across the bond. \cite{fedorov2008covalent,fedorov2009analytic,steinmann2012effective} Fragments connected by a covalent bond} share atoms (Figure~\ref{fig:bondregion}) through the bonding region so it is possible that one side changes the wave function of the bonding region\cite{steinmann2012effective}. It is therefore necessary to re-evaluate the internal \emph{ab initio} energy of region $b$ for each new geometry step.

The internal geometries of fragments in region $F$ are completely frozen so the internal energy is constant and is therefore neglected
\begin{equation}
\label{eqn:eintfrozen} E^0_F = 0.
\end{equation}
However, it is still necessary to compute the multipole moments and polarizability tensors (and therefore the wave function) of the fragments in $F$ once at the beginning of a geometry-optimization to evaluate $E_\mathrm{tot}^\mathrm{POL}$ in equation~\ref{eqn:energyregion} as well as some inter-region interaction energies defined as
\begin{align}
\label{eqn:crossba} E^0_{b/A} &= \sum_{\substack{I\in b\\ J\in A}}^{R_{I,J}\leq R_\mathrm{resdim}} \left(\Delta E_{IJ}^0 - E_{IJ}^\mathrm{POL} \right) + \sum_{\substack{I\in b\\ J\in A}}^{R_{I,J} > R_\mathrm{resdim}} E_{IJ}^\mathrm{ES}, \\
\label{eqn:crossfa} E^0_{F/A} &= \sum_{\substack{I\in A\\ J\in F}} E_{IJ}^\mathrm{ES}, \\
\label{eqn:crossfb} E^0_{F/b} &= 0.
\end{align}
Equation~\ref{eqn:crossfa} assumes that $b$ is chosen so that fragments in $A$ and $F$ are sufficiently separated (i.e.,  $R_{I,J} > R_\mathrm{resdim}$) so the interaction is evaluated classically. If all atoms in region $b$ are frozen, then $E^0_{F/b}$ is constant and can be neglected. However, this assumes that the positoins of all atoms at both sides of the bonds connecting fragments are frozen.

The final expression for the EFMO frozen domain (EFMO/FD) energy is
\begin{equation} \label{eqn:efmofinal}
E^{\mathrm{EFMO}} = E^0_b + E^0_A + E^0_{b/A} + \sum_{\substack{I\in A\\ J\in F}}^{R_{I,J} > R_\mathrm{resdim}} E_{IJ}^\mathrm{ES} + E_\mathrm{tot}^\mathrm{POL}.
\end{equation}
Finally, we note that due to the frozen geometry of $b$ we can further gain a speedup by not evaluating dimers in $b$ (cross terms between $A$ and $b$ are handled explicitly according to equation~\ref{eqn:crossba}) since they do not contribute to the energy or gradient of $A$. This corresponds to the frozen domain with dimers (EFMO/FDD), and equation~\ref{eqn:regionbenergy} becomes
\begin{equation}
\label{eqn:approxregionb}
E^0_b = \sum_{I\in b}^N E_I^0.
\end{equation}
The gradient of each region is
\begin{align}
\frac{\partial E^{\mathrm{EFMO}}}{\partial x_A} &= \frac{\partial E^0_A}{\partial x_A} + \frac{\partial E^0_{A/b}}{\partial x_A} + \frac{\partial E^0_{A/F}}{\partial x_A} + \frac{\partial E_\mathrm{tot}^\mathrm{POL}}{\partial x_A}, \\
\label{eqn:gradregionb}\frac{\partial E^{\mathrm{EFMO}}}{\partial x_b} &= 0, \\
\frac{\partial E^{\mathrm{EFMO}}}{\partial x_F} &= 0,
\end{align}
and the details of their evaluation has been discussed previously\cite{steinmann2010effective,steinmann2012effective}. Equation~\ref{eqn:gradregionb} does not apply to non-frozen atoms shared with region $A$.

The frozen domain formulation of EFMO was implemented in GAMESS\cite{schmidt1993general} and parallelized using the generalized distributed data interface\cite{FMO3,fedorov2004new}.

\section*{Computational Details}

\subsection*{Preparation of the Enzyme Model}
We followed the strategy by Claeyssens \emph{et~al.}\cite{claeyssens2011analysis} The structure of chorismate mutase (PDB: 2CHT) solved by Chook \emph{et~al}.\cite{chook1993crystal} was used as a starting point. Chains A, B and C were extracted using PyMOL\cite{schrodinger2010pymol} and subsequently protonated with PDB2PQR\cite{dolinsky2004pdb2pqr,dolinsky2007pdb2pqr} and PROPKA\cite{li2005very} at $\mathrm{pH} = 7$. {\color{black}The protonation state of all residues can be found in Table~S1.} The inhibitor between chain A and C was replaced with chorismate in the reactant state (\textbf{1}, Figure~\ref{fig:chorismate}) modeled in Avogadro\cite{avogadro,avogadro2012paper}.

The entire complex (chorismate mutase and chorismate) was solvated in water (TIP3P\cite{jorgensen1983comparison}) using GROMACS. \cite{van2005gromacs,hess2008gromacs} {\color{black} To neutralize the system 11 Na$^{+}$ counter ions were added.} The protein and counter ions were treated with the CHARMM27\cite{kerell2000development,brooks2009charmm} force field in GROMACS. Force-field parameters for chorismate were generated using the SwissParam\cite{zoete2011swissparam} tool. To equilibrate the complex a $100$ ps NVT run at $T=300\unit{K}$ was followed by a $100\unit{ps}$ NPT run at $P=1\unit{bar}$ and $T=300\unit{K}$. The production run was an isothermal-isobaric trajectory run for $10$ ns. A single conformation was randomly selected from the last half of the simulation and energy minimized in GROMACS to a force threshold of $F_\mathrm{max}=300 \unit{KJ}\unit{mol^{-1}}\unit{nm^{-1}}$. During equilibration and final molecular dynamics (MD) simulation, the $\chem{C}3$ and $\chem{C}4$ atoms of chorismate (see Figure~\ref{fig:chorismate}) were harmonically constrained to a distance of 3.3 {\AA} to keep it in the reactant state. Finally, a sphere of 16 {\AA} around the C1 atom of chorismate was extracted in PyMOL and hydrogens were added to correct the valency where the backbone was cut. The final model  contains a total of 2398 atoms.

\subsection*{Mapping the Reaction Path}
To map out the reaction path, we define the reaction coordinate similarly to Claeyssens \emph{et~al.}\cite{claeyssens2011analysis} as the difference in bond length between the breaking O2-C1 bond and the forming C4-C3 bond in chorismate (see also Figure~\ref{fig:chorismate}), i.e.
\begin{equation}
\label{eqn:reactioncoordinate}
R = R_\mathrm{21} -R_\mathrm{43}.
\end{equation}
The conversion of chorismate ($R=-2.0$~{\AA}, $R_{21} = 1.4$~{\AA}, $R_{43} =-3.4$~{\AA}) to prephenate ($R=1.9$ {\AA}, $R_{21} = 3.3$~{\AA}, $R_{43} =1.4$~{\AA}) in the enzyme was mapped by constraining the two bond lengths in equation~\ref{eqn:reactioncoordinate} with a harmonic force constant of 500 kcal mol$^{-1}$ \AA$^{-2}$ in steps of $0.1$~{\AA}. For each step, all atoms in the active region ($A$) were minimized to a threshold on the gradient of $5.0\cdot10^{-4}$ Hartree Bohr$^{-1}$ (OPTTOL=5.0e-4 in \$STATPT). For the enzyme calculations we used EFMO-RHF and FMO2-RHF with the frozen domain approximation presented above.

We used two different sizes for the active region small: (EFMO:$\mathbf{S}$, Figure~\ref{fig:modelfull}) and large (EFMO:$\mathbf{L}$, Figure~\ref{fig:modelfull_l}). The active region (colored red in Figure~\ref{fig:active}) is defined as all fragments with a minimum distance $R_\mathrm{active}$ from any atom in chorismate (EFMO:$\mathbf{S}:R_\mathrm{active}=2.0$ {\AA}, EFMO:$\mathbf{L}:R_\mathrm{active}=3.0$ {\AA}). In EFMO:$\mathbf{S}$ the active region consists of chorismate, 4 residues and 5 water molecules, while the active region in EFMO:$\mathbf{L}$ consists of chorismate, 11 residues and 4 water molecules. The buffer region (blue in Figure~\ref{fig:active}) is defined as all fragments within $2.5$ {\AA} of the active region for both EFMO:$\mathbf{S}$ and EFMO:$\mathbf{L}$. The rest of the system is frozen. To prepare the input files we used FragIt\cite{steinmann2012fragit}, which automatically divides the system into fragments; in this work we used the
fragment size of one amino acid residue or water molecule per fragment.

In order to refine the energetics, for each minimized step on the reaction path we performed two-layer ONIOM\cite{svensson1996oniom,dapprich1999new} calculations
\begin{equation}
E^\mathrm{high}_\mathrm{real} \approx E^\mathrm{low}_\mathrm{real} + E^\mathrm{high}_\mathrm{model} - E^\mathrm{low}_\mathrm{model},
\end{equation}
where $E^\mathrm{low}_\mathrm{real} = E^\mathrm{EFMO}$ according to equation~\ref{eqn:energyregion}. This can be considered a special
case of the more general multicenter ONIOM based on FMO \cite{ONIOM-FMO}, using EFMO instead of FMO. The high level model system is chorismate in the gas-phase calculated using B3LYP\cite{becke1993new,stephens1994ab,hertwig1997parameterization} (DFTTYP=B3LYP in \$CONTRL) or MP2 (MPLEVL=2 in \$CONTRL) with either 6-31G(d) or the cc-pVDZ{\color{black}, cc-pVTZ and cc-pVQZ basis sets} by Dunning \cite{dunning1989gaussian}.

We also carried out multilayer EFMO and FMO\cite{fedorov2005multilayer} single-point calculations where region $F$ is described by RHF/6-31G(d) and $b$ and $A$ (for EFMO) or $B$ ($B=A \cup b$ for FMO \cite{fedorov2011geometry}) is calculated using MP2/6-31G(d).

The FDD approximation in equation~\ref{eqn:approxregionb} is enabled by specifying MODFD=3 in \$FMO, similarly to the frozen domain approach in FMO\cite{fedorov2011geometry}. All calculations had spherical contaminants removed from the basis set (ISPHER=1 in \$CONTRL).

\subsection*{Obtaining the Activation Enthalpy}
The activation enthalpy is obtained in two different ways by calculating averages of $M$ adiabatic reaction pathways. The starting points of the $M$ pathways were randomly extracted from the MD simulation, followed by the reaction path mapping procedure described above for each pathway individually. One way to obtain the activation enthalpy averages the barriers from each individual adiabatic reaction path \cite{claeyssens2006high}
\begin{equation}
\label{eqn:enthalpy1}
\Delta H_1^\ddagger = \frac{1}{M} \sum_{i=1}^M \left(E_{\mathrm{TS},i} - E_{\mathrm{R},i}\right) -1.6\,\mathrm{kcal\,mol}^{-1}.
\end{equation}
Here $M$ is the number of reaction paths ($M = 7$, Figure~\ref{fig:average}) $E_{\mathrm{TS},i}$ is the highest energy on the adiabatic reaction path while $E_{\mathrm{R},i}$ is the lowest energy with a negative reaction coordinate. 1.6 kcal mol$^{-1}$ corrects for the change in zero point energy and thermal contributions\cite{claeyssens2006high}.

The other way of estimating the activation enthalpy is \cite{ranaghan2004transition}:
\begin{equation}
\label{eqn:enthalpy2}
\Delta H_2^\ddagger = \langle E_{\mathrm{TS}}\rangle - \langle E_\mathrm{R}\rangle - 1.6\,\mathrm{kcal\,mol}^{-1}.
\end{equation}
Here $\langle E_{\mathrm{TS}}\rangle$ and $\langle E_\mathrm{R}\rangle$ are, respectively, the highest energy and lowest energy with a negative reaction coordinate on the averaged adiabatic path (bold line in Figure~\ref{fig:average}). The brackets here mean averaging over 7 reaction paths; and the difference of Eqs \ref{eqn:enthalpy1} and \ref{eqn:enthalpy2} arises because of the noncommutativity of the sum and the min/max operation over coordinates: in Eq \ref{eqn:enthalpy1} we found a minimum and a maximum for each curve separately, and averaged the results, but in Eq \ref{eqn:enthalpy2} we first averaged and then found the extrema. As discussed below, the two reaction enthalpies are within 0.2 kcal/mol, which indicates that the TS occurs at roughly the same value of the reaction coordinate for most paths.

\section*{Results and Discussion}

\subsection*{Effects of Methodology, Region Sizes and Approximations}
\label{sect1}
Reaction barriers obtained in the enzyme using harmonic constraints are plotted on Figure~\ref{fig:rhfbarrier} and listed in Table~\ref{tbl:rhfbarriers} for different settings of region sizes and approximations. All calculated reaction barriers are within 0.5 kcal mol$^{-1}$ from each other when going from the reactant ($R_R$) to the proposed transition ($R_{TS}$) state where the reaction barriers for the TSs are around 46 kcal mol$^{-1}$. The same is true when going to the product $R_P$. Only the large model (EFMO:$\mathbf{L}$) shows a difference in energy near the product ($R_P$) with a lowering of the relative energy by 4 kcal mol$^{-1}$ compared to the other settings.

The reaction coordinates are also similar for the small systems ($R_P=1.41$ \AA, except for $R_\mathrm{resdim}=2.0$ which is $R_P=1.56$ \AA) with some minor kinks on the energy surface from optimization of the structures without constraints at $R_P$. The EFMO:\textbf{L} model has a different reaction coordinate for the product ($R_P=1.57$ \AA) and also a shifted reaction coordinate for the transition state $R_{TS}=-0.12$ \AA\, which we can attribute to a better description of more separated pairs in the active region but more importantly that around the TS, the energy surface is very flat. Interestingly, using FMO2 shows no significant change in either reaction barriers or reaction coordinates for the reactant, transition state or product which differ from EFMO:\textbf{S} by 0.02 \AA, 0.03 \AA\, and 0.01 \AA\, respectively. Timings are discussed below.

Previous work by Ranaghan \emph{et~al.}\cite{ranaghan2003insights,ranaghan2004transition} obtained an RHF barrier of $36.6$ kcal mol$^{-1}$ which is 10 kcal/mol lower than what we obtained. Also, they observed that the transition state happened earlier at $R_{TS} = -0.3$ \AA. The difference in reaction barrier from our findings is attributed to a poorer enzyme structure and other snapshots do yield similar or better reaction barriers (see below). Furthermore, the same study by Ranaghan et al. found that the reaction is indeed exothermic with a reaction energy of around $-30$ kcal mol$^{-1}$ at the RHF/6-31G(d) level of theory. We expect this difference from our results to arise from the fact the study by Ranaghan et al. used a fully flexible model for both the substrate and the enzyme where the entire protein is free to adjust contrary to our model where we have chosen active fragments and atoms in a uniform sphere around a central fragment. This is perhaps not the best solution if one includes too few fragments (which lowers the computational cost) due to fragments in the buffer region are unable to move and cause steric clashes. The lowering of the energy for EFMO:\textbf{L} suggests this.

\subsection*{Refined Reaction Energetics}
\label{sect2}
For the smallest EFMO:\textbf{S} system ONIOM results are presented on Figure~\ref{fig:oniombarrier} and in Table~\ref{tbl:oniombarriers} for various levels of theory. By calculating the MP2/cc-pVDZ:EFMO-RHF/6-31G(d) energy using ONIOM we obtain a 19.8 kcal mol$^{-1}$ potential energy barrier. Furthermore, the reaction energy is lowered from $-1.3$ kcal mol$^{-1}$ to $-5.5$ kcal mol$^{-1}$. {\color{black}Increasing the basis set size through cc-pVTZ and cc-pVQZ reduces the barrier to 21.8 kcal mol$^{-1}$ and 21.7 kcal mol$^{-1}$, respectively and the reaction energy is -1.1 kcal mol$^{-1}$ and 0.8 kcal mol$^{-1}$.} Using the smaller 6-31G(d) basis set with MP2, the reaction barrier is 22.2 kcal mol$^{-1}$ and reaction energy is $-3.2$ kcal mol$^{-1}$. The B3LYP results are improvements for the TS only reducing the barrier to $23.8$ kcal mol$^{-1}$ for B3LYP/cc-pVDZ:EFMO-RHF/6-31G(d). The same is not true for the product where the energy is increased by about $3$ kcal mol$^{-1}$. For the other systems treated using EFMO-RHF/6-31G(d) discussed in the previous section ONIOM corrected results {\color{black}at the MP2 or B3LYP level of theory using a cc-pVDZ basis set} are listed in tables~S2 to S5 and show differences from the above by less than $1$ kcal mol$^{-1}$, again the reaction coordinates changes slightly depending on the system. {\color{black}The effect of including correlation effects by means of MP2 and systematically larger basis sets is that the potential energy barrier for the reaction rises as more correlation effects are included, the same is true for the overall reaction energy.}

The results presented here for MP2 are in line with what has been observed previously by Ranaghan \emph{et~al.}\cite{ranaghan2004transition} and Claeyssens \emph{et~al.}\cite{claeyssens2011analysis}. Overall, the reaction barrier is reduced to roughly half of the RHF barrier and the observed coordinates for the reaction shift slightly. We do note that this study and the study by Ranaghan \emph{et~al.} use ONIOM style energy corrections for the correlation and not geometry optimizations done at a correlated level. Overall, we observe that the predicted reaction coordinate for the approximate transition state in the conversion of chorismate to prephenate happens around $0.2$ {\AA} later than in those studies.

The results for the multilayer single points along the energy surface are presented in Table~\ref{tbl:efmomp2barrier}. The barrier calculated at the EFMO-RHF:MP2/6-31G(d) level of theory is predicted to be $27.6$ kcal mol$^{-1}$ which is {\color{black}5.4} kcal mol$^{-1}$ higher than the ONIOM barrier and the reaction coordinates are shifted for both the reactant and the TS from $R_{R}=-1.95$ {\AA} ~to $R_{R}=-1.64$ {\AA} ~and $R_{TS}=-0.36$ {\AA} ~to $R_{TS}=-0.11$ {\AA}. Similar results are obtained at the FMO2-RHF:MP2/6-31G(d) level of theory. {\color{black}The difference from the ONIOM corrected values in table~\ref{tbl:efmomp2barrier} is likely due to the inclusion of dispersion effects between the chorismate and the enzyme which is apparently weaker at the transition state compared to the reactant state.}

\subsection*{Ensemble Averaging}
In Figure~\ref{fig:average} and Figure~\ref{fig:average_cct} we show 7 adiabatic reaction paths mapped with EFMO-RHF/6-31G(d) starting from 7 MD snapshots; the energetics were refined with ONIOM at the MP2/cc-pVDZ {\color{black}and MP2/cc-pVTZ level}. In EFMO, we used a small active region (EFMO:\textbf{S}) and $R_\mathrm{resdim}=1.5$ and no dimer calculations in region $b$ (S15FD3 in Figure~\ref{fig:rhfbarrier}). Out of the 7 trajectories one is described in detail in the previous sub-section.

For MP2/cc-pVDZ:EFMO-RHF/6-31G(d) the reaction enthalpies are $\Delta H_1^\ddagger = 18.3 \pm 3.5$ kcal mol$^{-1}$ and $\Delta H_2^\ddagger = 18.2$ kcal mol$^{-1}$ [cf. Equations (\ref{eqn:enthalpy1}) and (\ref{eqn:enthalpy2})], the latter having an uncertainty of the mean of $6.9$ kcal mol$^{-1}$. {\color{black}For MP2/cc-pVTZ:EFMO-RHF/6-31G(d) the reaction enthalpies are $\Delta H_1^\ddagger = 19.3 \pm 3.7$ kcal mol$^{-1}$ and $\Delta H_2^\ddagger = 18.8$ kcal mol$^{-1}$ with an uncertainty of the mean of $7.1$ kcal mol$^{-1}$.} These barriers are ca $5.5$ {\color{black}($6.5$)} kcal mol$^{-1}$ higher than the experimental value of $12.7 \pm 0.4$ kcal mol$^{-1}$ for MP2/cc-pVDZ {\color{black}(MP2/cc-pVTZ)}. For comparison, the activation enthalpy obtained by Claeyssens \emph{et~al.}  \cite{claeyssens2006high,claeyssens2011analysis} ($9.7 \pm  1.8$ kcal mol$^{-1}$) is underestimated by $3.0$ kcal mol$^{-1}$.

There are several differences between our study and that of Claeyssens \emph{et~al.} that could lead to an overestimation of the barrier height: biasing the MD towards the TS rather than the reactant, a larger enzyme model (7218 vs 2398 atoms), and more conformational freedom when computing the potential energy profile.

With regard to the latter point, while Figure~\ref{fig:rhfbarrier} shows that increasing the active region has a relatively small effect on the barrier this may not be the case for all snapshots.  We did identify one trajectory that failed to produce a meaningful reaction path and is presented in Figure S1. Here, the energy of the barrier becomes unrealistically high because of very little flexibility in the active site and unfortunate placement of Phe57 (located in the buffer region, Figure S2), which hinders the conformational change needed for the successful conversion to prephenate yielding an overall reaction energy of around $+11$ kcal mol$^{-1}$. As noted above, the EFMO:\textbf{L} settings is a possible solution to this as more of the protein in available to move, but as seen from Table~\ref{tbl:rhfbarriers} the computational cost doubles.

\subsection*{Timings}
Using the computationally most efficient method tested here (EFMO:\textbf{S}), $R_\mathrm{resdim}=1.5$, and skipping dimers in the buffer region $b$, an adiabatic reaction path, which requires a total of 467 gradient evaluations, can be computed in four days using 80 CPU cores (20 nodes with 4 cores each) at the RHF/6-31G(d) level of theory. As shown in Table~\ref{tbl:rhfbarriers}, the same calculation using FMO2 requires takes roughly $T^\mathrm{full}_\mathrm{rel}=7.5$ times longer.

Increasing $R_\mathrm{resdim}$ from 1.5 to 2 has a relatively minor effect of the CPU time (a factor of 1.2), while performing the dimer calculations in the buffer region nearly doubles (1.7) the CPU time.  Similarly, increasing the size of active region from $2.0$ \AA ~to $3.0$ \AA ~around chorismate also nearly doubles (1.8) the CPU time. This is mostly due to the fact that more dimer calculations must be computed, but the optimizations also require more steps (513 gradient evaluations) to converge due to the larger number of degrees of freedom that must be optimized.

Looking at a single minimization for a specific reaction coordinate $R=-1.79$ {\AA}, the most efficient method takes 4.5 hours. Here, the relative timings $T_\mathrm{rel}$ are all larger than for the full run ($T^\mathrm{full}_\mathrm{rel}$) due to a slight increase in the number of geometry steps (around 25) taken for all but FMO2 which is identical to the reference (22 steps). Thus, the overall cost of performing the FMO2 minimization is 6.7 times as expensive as EFMO.

\section*{Summary and Outlook}
In this paper we have shown that the effective fragment molecular orbital (EFMO) method \cite{steinmann2010effective,steinmann2012effective} can be used to efficiently map out enzymatic reaction paths provided the geometry of a large part of the enzyme and solvent is frozen. In EFMO one defines an active region associated with the active site, and the cost of a geometry optimization is then essentially the cost of running quantum-mechanical calculations of the active domain. This is similar to the cost of QM/MM, if the QM region is the same; the difference is that in EFMO we freeze the coordinates of the rest of the system, whereas in QM/MM they are usually fully relaxed. On the other hand, EFMO does not require parameters and can be better considered an approximation to a full QM calculation rather than a QM/MM approach.

In this work we used the mapping technique based on running a classical MD simulation, selecting some trajectories, freezing the coordinates of the outside region, and doing constrained geometry optimizations along a chosen reaction coordinate. An alternative to this approach is to run full MD simulation of a chemical reaction using EFMO. This has already been done for many chemical reactions using FMO-MD \cite{fmomd,sato2008does,fmomd-rev} and can be done in future with EFMO.

A potential energy profile for the chorismate to prephenate reaction in chorismate has been computed in 4 days using 80 CPU cores for an RHF/6-31G(d) description of a truncated model of the enzyme containing 2398 atoms. For comparison, a corresponding FMO2 calculation takes about 7.5 times more. The cost of EFMO calculations is mainly determined by the size of the buffer- and active region. Comparing to a QM/MM
with QM region of the same size, EFMO as a nearly linear scaling method, becomes faster than QM if the system size is sufficiently large; especially for correlated methods like MP2 where this cross-over should happen with relatively small sizes.

Our computed conformationally-averaged activation enthalpy is in reasonable agreement to the experimental value, although overestimated by 5.5 kcal/mol.

The energetics of this reaction depends on the level of calculation. We have shown that by using a level better than RHF, for instance, MP2 or DFT, considerably improves the energetics and by using such an appropriate level to also determine the reaction path following the formalism in this work can be used to provide a general and reliable way in future.

EFMO, as one of the fragment-based methods \cite{gordon2012fragmentation}, can be expected to be useful in various biochemical
studies, such as in enzymatic catalysis and protein-ligand binding. It should be noted that in addition to its paramater-free
ab initio based nature, EFMO and FMO also offer chemical insight on the processes by providing subsystem information, such
as the properties of individual fragments (e.g., the polarization energy) as well as the pair interaction energies
between fragments \cite{piedagas,piedapcm}. This can be of considerable use to fragment-based drug discovery \cite{fbdd,gamess-drug}.

\section*{Acknowledgements}
CS and JHJ thank the Danish Center for Scientific Computing at the University of Copenhagen for providing computational resources. DGF thanks the Next Generation Super Computing Project, Nanoscience Program (MEXT, Japan) and Strategic Programs for
Innovative Research (SPIRE, Japan).

redpajama_set_name: RedPajamaArXiv


text:
Q: Why is a unique Sylow p-subgroup normal? I need to prove that a group $G$ with $|G| = pq$, where $p$, $q$ are primes, cannot be simple. I have already reduced this problem to showing that a unique Sylow $p$-subgroup is normal. The answers i have found so far are something along the line of "the Sylow $p$-subgroup is normal because all $p$-Sylow subgroups are conjugate to each other" which means diddly-squat to me. I need help understanding that last part.

A: Suppose that $H$ is the unique $p$-Sylow subgroup, for any $g\in G, gHg^{-1}$ is also a $p$-Sylow subgroup since it has the same cardinal than $H$, since $H$ is the unique $p$-Sylow subgroup, $gHg^{-1}=H$ so for every $h\in H, ghg^{-1}\in H$ and $H$ is normal.

redpajama_set_name: RedPajamaStackExchange


Balmain's Olivier Rousteing injects his signature glamour and elegance into the brand's SS18 collection, presenting statement footwear for the modern woman. Expertly sculpted in Italy from sumptuous brick suede, these ankle boots will offer a sleek finishing touch to any ensemble. The pair features a high block heel with a gold-tone metal panel, a pointed toe and a side zip fastening.


text:
Q: Json to C# object display in Windows Phone's ListBox I used http://json2csharp.com to generate the C# class from the below JSON string.
{
    "stationArr":[
        {
            "id":"9",
            "name":"name9",
        "sidebar":{
                "original":"http://myurl.com/station_images/5/5_s.png",
                "m":"http://myurl.com/station_images/5/m/5_s_m.png",
                "s":"http://myurl.com/station_images/5/s/5_s_s.png"
            }
        },
    {
            "id":"3",
            "name":"name3",
        "sidebar":{
                "original":"http://myurl.com/station_images/5/5_s.png",
                "m":"http://myurl.com/station_images/5/m/5_s_m.png",
                "s":"http://myurl.com/station_images/5/s/5_s_s.png"
            }
    ]
    "stationUrlMap":{
        "9":"http://myurl.com/9_64",
        "3":"http://myurl.com/3_64",
    }
}

The generated classes are (I created different .cs for each class.
public class Sidebar
{
    public string original { get; set; }
    public string m { get; set; }
    public string s { get; set; }
}

public class StationArr
{
    public string id { get; set; }
    public string name { get; set; }
    public Sidebar sidebar { get; set; }
}

/*public class StationUrlMap
{
    public string __invalid_name__9 { get; set; }
    public string __invalid_name__3 { get; set; }
}
*/
public class StationList
{
    public List<StationArr> stationArr { get; set; }
//    public StationUrlMap stationUrlMap { get; set; } Dicarded it
}

I have discarded the StationUrlMap as I don't need it.
I am using the following code to create the Object
string resultString = sd.ReadToEnd();
StationList stations = JsonConvert.DeserializeObject<StationList>(resultString);
Debug.Writeline(stations.stationArr.Count); // gives Output 9 Which is correct.

I just don't know how to display the List of stations in the UI (using ListBox). Please guide me in the right direction.

A: Create a ListBox in the XAML
<ListBox x:Name="ListBoxStations" Height="500" >
    <ListBox.ItemTemplate>
        <DataTemplate>
            <StackPanel Orientation="Horizontal" Width="450">
                 <Image Source="{Binding Path=sidebar.original}"/>
                 <TextBlock Text="{Binding Path=name}"/>
            </StackPanel>
        </DataTemplate>
    </ListBox.ItemTemplate>
</ListBox>

And then in your cs file, after the json conversion do the following
StationList stations = JsonConvert.DeserializeObject<StationList>(resultString);
ListBoxStations.ItemsSource = stations.stationArr;

The above XAML code is just a sample, change based on your requirements.

A: There are two ways.
First you can set the listbox's ItemSource property to the list you just created.
Second, You can create an ObservableCollection of thing in your list, and bind the observable collection to the listbox's ItemSource property. Add items in the Observable Collection and these will be displayed in your listbox.
The second way gives you more control over the items in the lisbox. You can remove or add elements in the observable collection and that will reflect in the listbox contents. The first method will make the contents of the list read-only, and you will not be able to add or remove items from it.
http://msdn.microsoft.com/en-us/library/ms668604.aspx
http://msdn.microsoft.com/en-us/library/system.windows.controls.listbox%28v=vs.95%29.aspx


text:
McDonalds is Giving Away Free Egg McMuffins Today
Jen Austin Published: March 2, 2020
McDonald's has declared today to be National Egg McMuffin Day and they're giving away free Egg McMuffins to celebrate. But there's a bit of an ulterior motive behind it.
Wendy's is launching its nationwide breakfast menu this week to compete with McDonald's and other quick breakfast spots, and McDonald's has not-so-coincidentally decided to give out some of its breakfast menu items today for free. Here, have one everybody.
But you've got to order the Egg McMuffin on the McDonald's app to get it for free, and the offer is only valid today from 6 am to 10:30 am our time.
McDonald's said that today is intended to celebrate the "best" fast food breakfast sandwich as it turns 50 this year. It just so happens that today is the same day Wendy's takes its new breakfast menu nationwide.
The breakfast sandwich war is getting intense. McDonald's recently added two chicken breakfast sandwiches to its menus trying to better compete with Popeye's and Chick-fil-A. Chicken used to be mostly for lunch and dinner, and now it seems to work as a 6 am kickstarter. And bacon has grown from primarily a breakfast thing, to around the clock too.
Food Insider via Youtube
Don't even get us started on that new KFC Chicken and Donuts creation. The breakfast war has spawned some crazy food inventions, and we probably haven't seen the last of those sweet-savory, fat-on-fat, sugary inventions. Wendy's has a chicken biscuit sandwich on its new breakfast menu too, plus nine other sandwiches, including a Bacon Egg and Cheese sandwich and a morning version of the Baconator. It's all launching this week.
Can you eat right when you wake up or does a waiting period have to pass before you're ready? My middle schooler has no interest in food when she wakes up, and I'm a slow-starter too. I've got to let the coffee kick in first and then add food three or four hours later, and that makes it easy to miss the breakfast windows at restaurants. But they know that our schedules are all over the place, and more of them are adding all-day breakfast menus because of it.
If you missed the McDonald's freebie today, we have a feeling there will be more chances soon. This breakfast war could work out well for all of us.
Filed Under: Breakfast, free, mcdonalds, news
Inflation Gone Wild? Breakfast for Two in Billings Over $30
Free TV? Channels Available in Billings with an OTA Antenna
Several Dead Following Shooting at Uvalde, Texas Elementary School
I Tried 10 Chicken Fried Steaks in Billings. The Clear Winner Is…
We Asked, You Answered: 3 Best Weekend Breakfast Joints in Billings
Unique Cafe in Livingston Serves Up Best Breakfast in Montana
End of an Era? McDonald's Getting Rid of Plastic Happy Meal Toys
Film Set in Montana Featuring Benedict Cumberbatch Debuts Trailer
Big Sky Passenger Rail Gains Momentum To Become Reality


text:
https://sputniknews.com/20201223/cyberattack-on-eu-drugs-agency-possibly-carried-out-by-foreign-intelligence-reports-claim-1081553318.html
Cyberattack on EU Drugs Agency Possibly Carried Out by Foreign Intelligence, Reports Claim
MOSCOW (Sputnik) - Foreign special services could have been behind the cyberattack on the European Medicines Agency (EMA) earlier this month, Dutch broadcaster... 23.12.2020, Sputnik International
https://cdnn1.img.sputniknews.com/img/07e4/0c/17/1081553281_0:257:2731:1793_1920x0_80_0_0_e7184522935b509f378af078311b598d.jpg
https://cdnn1.img.sputniknews.com/img/07e4/0c/17/1081553281_0:0:2731:2048_1920x0_80_0_0_aace85f2626ecffb4b30cd0827d39abe.jpg
europe, newsfeed, eu, cyberattack
CC BY 2.0 / Flickr / Blogtrepreneur / Data Security Breach
CC BY 2.0 / Flickr / Blogtrepreneur /
MOSCOW (Sputnik) - Foreign special services could have been behind the cyberattack on the European Medicines Agency (EMA) earlier this month, Dutch broadcaster NOS reported on Wednesday, citing sources.
EMA reported the cyberattack on December 9, launching an investigation to find out which of its systems exactly had been hacked. Among other things, the agency is responsible for reviewing vaccines and making recommendations on their use and sale in the European Union.
"EMA has been the subject of a cyberattack. The Agency has swiftly launched a full investigation, in close cooperation with law enforcement and other relevant entities", the agency said in a statement.
According to the report, foreign intelligence services were specifically after information about the coronavirus vaccines developed by the Pfizer-BioNTech duo and Moderna.
Pfizer and BioNTech released a statement in which they stressed that their IT systems remained secure, including patients' personal data.
"Today, we were informed by the European Medicines Agency (EMA) that the agency has been subject to a cyberattack and that some documents relating to the regulatory submission for Pfizer and BioNTech's COVID-19 vaccine candidate, BNT162b2, which has been stored on an EMA server, had been unlawfully accessed," the statement said. "It is important to note that no BioNTech or Pfizer systems have been breached in connection with this incident and we are unaware that any study participants have been identified through the data being accessed."
The broadcaster's source said that the cyberattack was noticed when perpetrators used the credentials of an EMA employee to log into the corporate system after-hours.
The report did not point at any particular foreign government.
cyberattack
hacker attack


text:
L'aérodrome de Malbouhans (anciennement LFYL) est un site militaire désaffecté ayant servi entre les années 1950 et 1998 de piste annexe de décollage de la Base aérienne 116 Luxeuil-Saint Sauveur. Il est situé au nord-est de la ville de Lure dans le département français de la Haute-Saône.

Stratégique pendant la Guerre froide, il fait l'objet de plusieurs tentatives de reconversion, avant de se retrouver partiellement en friche au début du .

Localisation
Il est majoritairement situé sur le territoire des communes de Malbouhans et La Neuvelle-lès-Lure, mais déborde également sur les limites des communes de Lure, Saint-Germain, Froideterre, Roye et La Côte ; toutes ces communes faisant partie du département de la Haute-Saône, en région Bourgogne-Franche-Comté.

Histoire

Histoire pré-militaire
Avant 1947, le site est une vaste plaine herbeuse servant de piste d'atterrissage.

Guerre froide
La piste est aménagée en béton dans les années 1950 selon les normes de l'OTAN. Un balisage lumineux est mis en place à la fin de la décennie.
Le site, stratégique pendant la Guerre froide, accueille d'abord des F-100 puis des Mirage  de la Base aérienne 116 Luxeuil-Saint Sauveur.

Les constructions en béton sont très rares et les avions sont stockés à découvert la plupart du temps ; en général sur deux aires disposées en marguerite et des zones de dispersions en trompette en bout de piste. Des hangars en toile à structure métallique permettent d'abriter les avions lors d'opérations de maintenance délicates. La base vie est essentiellement composée de bâtiments en tôle type Fillod. Il existe deux dépôts de munitions, le premier dans l'emprise de l'aérodrome, le second, à l'extérieur du site, à  au nord-ouest, sur le territoire de la commune de Saint-Germain.

Le site est définitivement retiré du domaine aéronautique en 1998.

Reconversion

Il est racheté par le Conseil général de la Haute-Saône en 2005 dans le but de lui redonner une nouvelle vie. Toutefois, le projet est interrompu par des revendications écologiques, l'aérodrome étant reconnu comme zone naturelle d'intérêt écologique, faunistique et floristique (ZNIEFF). Le projet, toujours d'actualité, consiste en la reconversion des structures existantes en un petit pôle de compétitivité (véhicules du futur). L'espace de près de  est utilisé plusieurs fois par an pour de grandes manifestations telles que des compétitions automobiles, des concours de labour et des raves parties.

En 2021, EDF Renouvelables projette d'installer une centrale photovoltaïque sur le site. Celle-ci occuperait une surface de  pour une puissance crête de  et pourrait être mise en service à l'horizon 2024.

Notes et références

Voir aussi

Articles connexes
 Base aérienne 116 Luxeuil-Saint Sauveur
 Bases aériennes de l'Armée de l'air française

Liens externes

Bibliographie

Aérodrome en France
Aéroport en Haute-Saône


text:
Kansas inspection alleges 11 violations at water park where 10-year-old boy died
May 22, 2018 / 10:40 PM / AP
TOPEKA, Kan. -- A recent state inspection found 11 alleged violations of amusement park regulations at a Kansas water park where a boy died in 2016. One of the violations is raising questions about whether a ride's parts are being replaced as quickly as recommended.
The Kansas Department of Labor made an audit of the public Tuesday, a day after issuing a notice of violations to the park. The department sent a team to the park last week to review inspection safety signs.
The department said the park must address dozens of issues raised by the audit and covered by the 11 counts of alleged violations. But it also said those issues "constitute a first offense" and issued a warning.
The water park company criticized the audit. Spokeswoman Winter Prosapio said in an email that it contained "misleading and false information" and that Schlitterbahn would challenge details in a letter to the department later this week that it plans to make public.
"Our commitment to safety remains our highest priority," she said.
The Kansas City park has been closed as planned since the end of its 2017 season last fall and is scheduled to reopen Friday. The department's notice did not suggest a move to keep the park or its rides from opening or that the agency would use its power to impose a $1,000 fine for each violation.
But department spokeswoman Barbara Hersh said state Attorney General Derek Schmidt's office has been made aware of the audit, and the department is "in discussions" with Wyandotte County District Attorney Mark Dupree about the findings. Hersh would not comment further, and a spokesman for the district attorney did not immediately return telephone and email messages.
The notice said, "Schlitterbahn representatives did not dispute the audit findings."
Prosapio said Schlitterbahn is addressing the bulk of the "administrative, record keeping, and documentation issues" raised by the audit and is challenging its accuracy in "several important respects."
Three charged in Schlitterbahn waterslide death
Department of Labor officials promised in March to conduct a full audit of the Schlitterbahn park's records after a local grand jury issued multiple criminal indictments over the death of 10-year-old Caleb Schwab in August 2016. He was decapitated while riding the 17-story Verruckt waterslide, which was billed as the world's tallest and has been shut down since his death.
Schlitterbahn has described the boy's death as a tragic accident. He was the son of state Rep. Scott Schwab, of the Kansas City suburb of Olathe, and his death prompted lawmakers to strengthen the state's regulation of amusement park rides in 2017.
One count in the department's notice deals with the park's Soaring Eagle ZipLine, a "dry" ride that pulls riders in a two-seat chair across the park, 100 feet above the ground. The audit said inspection checklists, trainer qualification and other records weren't available for inspection and added that it has not replaced parts as recommended by the manufacturer.
"The main drive cable has not been replaced" as "described in the manufacturer manual," another audit finding said.
Prosapio responded: "The report found no issues with the mechanical function of our rides."
Other findings in the audit said safety signs in some park areas were not adequate, records were not available for review and some operating and training manuals were not complete.
The co-owner of the Texas-based Schlitterbahn Waterparks and Resorts, one of the Verruckt slide's designers and the Kansas City park's former operations director all face numerous felony charges over Caleb Schwab's death, along with the company that built the slide. The charges included reckless second-degree murder against the company co-owner and ride designer.
A Wyandotte County judge has a July 12 pretrial hearing scheduled in their cases; all of the defendants have pleaded not guilty to all charges.
First published on May 22, 2018 / 10:40 PM


After a crazy-busy couple of weeks, I've got the Sidewalk Dog Sushi With Your Poochie photos edited and online! I feel like I've been going nonstop these days, with countless events, client sessions, photo editing, my 10-year class reunion, and kitten-sitting…. which I need to blog about soon, he's incredibly cute. So a HUGE thank you to everyone who's been so patient with me!
Here's some fun photos from the awesome event. The entire gallery can be viewed here: sarahbethphotography.com/photocart (click on Sushi With Your Poochie) and a portion of all file and print orders will go to MNSNAP!
So beautiful Sarah – you always present such a gorgeous and unique point of view – love it!!
Sarah – Your photos always put a smile on my face. You have a gift.
I loooooove that white boxer!!!


text:
By Team Hornak Las Vegas Bar Scene Las Vegas Bars Las Vegas Day clubs Las Vegas Nightclubs Las Vegas Nightlife Las Vegas Shows
Hakkasan Group's 2017 Las Vegas Roster
Calvin Harris, Tiesto, Kaskade, Zedd & More Announced for Hakkasan Group's 2017 Las Vegas Roster Hakkasan Group has announced its Las Vegas artist roster for 2017, highlighted with Calvin…
By Team Hornak Las Vegas Day clubs Las Vegas Events Las Vegas Nightclubs Las Vegas Nightlife Las Vegas Shows
AVN Nightclub at Light Nightclub
The AVN adult Entertainment Expo comes to Las Vegas this weekend, and everyone who is anyone in the adult industry will be in attendance. With the AVN expo in towns…
By Team Hornak Las Vegas Bars Las Vegas Day clubs Las Vegas Nightclubs Las Vegas Nightlife Las Vegas Pool Parties Las Vegas Shows
Wynn Nightlife Announces 2017 Las Vegas Resident DJs
by Kat Bein of Billboard.com Days after Wynn Nightlife announced an exclusive three-year residency with The Chainsmokers at its XS and Encore Beach Club properties, the entertainment company unveils…
By Team Hornak Las Vegas Events Las Vegas Nightlife Las Vegas Shows
Las Vegas Consumer Electronics Show 2017
This Weekend January 5th – 8ththe largest Tech Trade show of the year "Consumer Electronics Show" CES takes place in Las Vegas. The annual new tech unveiling will kick off the…
By Team Hornak Las Vegas Bars Las Vegas Events Las Vegas Nightclub Insider Las Vegas Nightclubs Las Vegas Nightlife Las Vegas Shows
New Years Eve Nightlife Guide 2017
What better place to ring in the New Year than the party capital of the world then Las Vegas? Here are the events going on here in Las Vegas on…
By Team Hornak Las Vegas Events Las Vegas Shows
Las Vegas Glittering Lights
It's that time of season, the weather has cooled off, the jackets have come out, and you're looking for things to do to get in the holiday spirit. You could…
By Team Hornak Las Vegas Events Las Vegas Nightclubs Las Vegas Nightlife Las Vegas Shows
Thanksgiving in Vegas! | Free Vegas Club Passes
Surrender Flossgiving Eve Nightclub Las Vegas Surrender the exquisite indoor/outdoor nightlife venue at Wynn Las Vegas. Come celebrate Thanksgiving Eve at Surrender Nightclub's Wednesday industry night "Flossgiving" party featuring a…
By Team Hornak Las Vegas Bachelorette Party Las Vegas Events Las Vegas Nightclubs Las Vegas Nightlife Las Vegas Shows
Ja Rule Rocks the House at LAX Nightclub
Ja Rule rocked a packed house at LAX Nightclub inside Luxor Hotel and Casino on last weekend, as LAX continued it resurgence with it's latest headliner. The New York rapper…
EDC Las Vegas 2017
EDC Vegas will return to Las Vegas Motor Speedway in 2017 for its 21st year. With much excitement and a heartfelt video, EDC Las Vegas has announced its return…
Alesso Halloween party 2016 at XS Las Vegas
https://youtu.be/f9TbnC7KZDg Alesso brought the party to XS Las Vegas Nightclub on Halloween. He got on stage at 1:30am, wearing a fake mustache, a striped shirt, with a pillow punch. He…
Life is Beautiful Weekend 2016
Life is Beautiful is an inspirational music, food, art and learning festival held in the heart of Downtown Las Vegas. Spread over 11 city blocks, with massive stages hosting over…
The 2016 iHeartRadio Music Festival Las Vegas
Friday, September 23rd and Saturday, September 24th are the dates for the 2016 iHEARTRADIO Music Festival with an two-day line-up of performances.The concert event will feature performances by U2, STING,…
Criss Angel MINDFREAK Live! in Las Vegas
Criss Angel Does it Again, MINDFREAK LIVE! is a Must See Spectacular. You won't know what's in store as Criss Angel takes you on a mind warping adventure with co-star…
By Team Hornak Las Vegas Events Las Vegas Nightclub Insider Las Vegas Nightlife Las Vegas Shows
The Dirty at 12:30 Comedy Show
The Dirty at 12:30 Comedy Show FREE at the South Point Hotel and Casino Produced by Gabe Lopez, "The Dirty at 12:30" is the hottest and hands down funniest FREE…
David Copperfield in Las Vegas at the MGM Grand
David Copperfield Live, you Won't Believe your Eyes. Don't miss this one in a lifetime opportunity to see one of the greatest showman of our time David Copperfield, as he…
OMNIA Nightclub Upcoming Events
OMNIA Nightclub at Ceasar's Palace Events 3570 South Las Vegas Boulevard, Las Vegas, NV Calvin Harris – Friday, July 29, 2016 Martin Garrix w/Julian Jordan – Saturday, July 30, 2016 Oliver Heldens…
By Team Hornak Las Vegas Bars Las Vegas Events Las Vegas Nightlife Las Vegas Shows
Eddie Griffin Live in Las Vegas
The Eddie Griffin Experience See Eddie Griffin live and uncensored at Rio Las Vegas. This show isn't for the faint at heart, so come with tough skin and be prepared…
Kesha @ Intrigue Nightclub
Kesha finished off her mini-residency at the Intrigue Nightclub in Las Vegas with a BANG. Using the final night of her residency to kick off her new 17-city tour will…
By Team Hornak Las Vegas Cocktails Las Vegas Dining Las Vegas Events Las Vegas Shows
Downtown Las Vegas Movie Nights
Eclipse Theatres Downtown Las Vegas Movie lovers will have a lot to be excited about with the new Eclipse Theatres. A movie theater is among the most wanted commercial attractions Downtown…
By Team Hornak Las Vegas Bars Las Vegas Events Las Vegas Shows
Las Vegas 4th of July Fireworks 2016
Caesars Palace Las Vegas Fireworks Show As part of Caesars Palace July 4th Celebration and marking its 50th anniversary with a "Summer of Caesars" celebration, on Sunday July 3, 2016…
Carrie Underwood at T-Mobile Arena
Carrie Underwood Coming to the T-Mobile Arena in November The T-Mobile Arena is the newest addition to the Las Vegas strip and is the ultimate entertainment venue. The T-Mobile Arena…
The Las Vegas Film Festival Part 9
The Las Vegas Film Festival Returns The Las Vegas Film Festival comes back to Downtown June 7-12, the festival celebrates cultural understanding and provides guests and participants with a chance…
LA LAKERS in Las Vegas
LA Lakers to Play 2 Preseason Games at T-Mobile Arena in Las Vegas With Los Angeles being very close to Las Vegas there are many Lakers fans in Las Vegas….
Gwen Stefani and EVE in Las Vegas
Gwen Stefani and EVE the This Is What the Truth Feels Like tour at T-Mobile Arena Las Vegas has many great events to come with singer, songwriter and fashion designer…
By Team Hornak Las Vegas Bars Las Vegas Events Las Vegas Nightclubs Las Vegas Nightlife Las Vegas Shows
Vegas – The I Love the 90's Tour
Relive the 90's Tomorrow Night and Mandalay Bay and Every Thursday at LAX The 90's had some of the best music hands down so relive the music of the 90's…
Drake and Future Summer Sixteen Tour
Drake and Future coming to the new T-Mobile Arena If you don't have Drake's new album VIEWS you are truly missing out. A day after the cover art for his upcoming…
Las Vegas Prince Tribute Show – Purple Reign
Purple Reign, The Prince Tribute Show Since his recent passing interest in Prince is at an all time high, the legendry artist with many songs that everyone can enjoy has…
Chris Tucker Live in Las Vegas
Chris Tucker to perform at the Pearl Theater at The Palms Hotel & Casino Comedian and actor Chris Tucker will return to the stage May 28, 2016 with a performance at…
AVICII CANCELS LAS VEGAS RESIDENCY
He plans to honor all remaining performances in 2016, but as he's canceled shows in the past, we can't be sure if he will follow through. Avicii (photo via The…
T-Mobile Arena Taking Vegas by Storm
T-Mobile Arena Las Vegas' new sports and entertainment venue, located just west of the famed Las Vegas Strip behind the New York New York Hotel and Casino is planing on…
By Team Hornak Las Vegas Bars Las Vegas Nightclubs Las Vegas Nightlife Las Vegas Shows
Coming Soon to Las Vegas the T-Mobile Arena
Las Vegas has a new arena for live events, thrilling sporting events, amazing music acts, and overall a new standard for what entertainment means in the entertainment capitol. The arena…
Michael Jackson ONE Las Vegas
The King of Pop has an incredible show called Michael Jackson ONE by Cirque de Soleil exclusively at the Mandalay Bay Resort. The show has an electrifying fusion of…