Everyone wants something different from a Christmas ad. Whether its traditional or modern, emotional or fun, or just completely different, we all have a favourite kind of campaign that gets us in the festive mood. Here at ALF, we've chosen our top picks of the festive advertising season and want you to help crown the winner. Scroll down to access our poll, cast your vote and wait to see which will be revealed as the most-loved Christmas ad in our final weekly newsletter before Christmas!
Advertisers must have seen their return on investment on their 2016 festive campaigns as we saw many, including Aldi, Intu and Very to name a few, bring back already established characters for their festive spots. But none of these resurgences works quite as well as Heathrow Airport's, which revived its travelling teddy bear characters for its 2017 spot. Last year we were introduced to Mr & Mrs Bair who returned home for Christmas and were greeted by their grandchildren at the airport. This year's spot gives us an insight into how the bears first met, using nostalgia – incidentally a tool utilised in a lot of this year's festive spots – to help us feel part of their romantic life journey.
As far as the battle of the department stores goes, M&S' ad blew iconic Christmas campaign creator John Lewis out of the park when it enlisted the help of family favourite character Paddington Bear for its festive effort. The endearing spot sees the innocent bear rumble a burglar without knowing it, when he mistakes the large man with a bag full of presents for Santa Claus himself. The robber ends up thanking Paddington for helping him redeliver the stolen presents (although some viewers have suggested that he says something a little less savoury!).
How many ways are there to cook a Christmas turkey? Tesco uses this question as the basis of its Christmas spot which allows the retailer to show the diverse range of people who celebrate the holiday and their unique ways of doing so. From struggling to squeeze it into a tiny oven to chucking it on the BBQ, no matter what the turkey technique, Tesco hopes to assure that it's the one to provide the goods this year.
Interestingly, both House of Fraser and Boots took a similar approach to their Christmas spots, with both retailers taking the viewer back in time to tell the tale of two sisters growing up through a series of Christmases. However, Boots' spot edged ahead by demonstrating the sentiment of its strapline 'show them you know them'. If there wasn't already enough 'smellies' gifted each Christmas, Boots is sure to make a few more sales with the help of this touching campaign.
Waitrose headed to a remote pub in Yorkshire to film its Christmas campaign this year. The black and white film sees local villagers enjoying a drink on a white Christmas morning when they find themselves snowed in. In typical northern fashion, everyone pulls together and lays on a festive spread which is about to be devoured, just as the rescue team arrive at the door to announce that they've cleared the snow freeing them to go home.
Last year, Amazon's tale of the gifting between an imam and priest was named the most effective Christmas ad of 2016 and was also the winner of ALF's annual Christmas ad poll. This year, the online giant takes a more light-hearted approach to its festive campaign which depicts the journey of a series of Amazon packages as they prepare to travel across the world to be gifted at Christmas. The magical ad brings the boxes to life and sees them take part in a rendition of Roger Hodgson's anthem 'Give a Little Bit'. If it wasn't possible to think of a cardboard box as cute, it is now.
Although Sainsbury's attempted to go down the musical entertainment route again in its Christmas spot this year, we felt like Sonos took this theme to the next level. The audio equipment manufacturer's festive work consists of a three-and-a-half-minute film directed by Jason Koenig, which sees a quiet Christmas day turned up a gear when one family member demands Sonos' smart speaker to play Dee-Lite's 'Groove in the Heart' across all the speakers in the house. What ensues is a quirky dancing frenzy which gets all of the family up on their feet.
Jigsaw enlisted the help of students at the National Film & Television School for its stop-motion Christmas spot. Another ad that uses the theme of 'Christmases over the years', the spot takes the viewer into a world of fabric and tells the story of two neighbours who anonymously leave each other gifts each year until they finally meet face to face in 2017.
We know we are UK-focused at ALF but we couldn't help but bring this sweet alternative Christmas tale by Swiss supermarket Migros to you this year. The spot turns our attention to an important, but often overlooked, element of the festive shopping season: the little workers inside cash desks that slave away scanning and 'beeping' our copious purchases. The film documents a day in the life of one of the miniature creatures at Christmas time and shows him longing to be part of the festivities which he sees in the outside world. However, one day a human shop assistant discovers him and makes his Christmas by letting him spend it with his fellow checkout chums after lights out.
TalkTalk's spot continues its 'This Stuff Matters' campaign which depicts the 'Merwick Street' family's home life in 'fly on the wall' style. Fittingly, we get to take a look at the family's Christmas celebrations in the telecoms provider's festive spot. Rather than the rose-tinted, snow-covered, twinkling Christmases we see in most ads, TalkTalk's gives a raw impression of the big day which, if not as spectacular, feels more relatable. From detangling the Christmas lights and struggling to wrap gifts, to novelty hats and slippers and tender embraces in the kitchen, the ad takes us through the whole rollercoaster of emotions that Christmas brings.
So, which ad gets you itching to hang up the tinsel and reaching for a mince pie? Click here to cast your vote!


text:
Official Hampton Roads Soccer Affiliate of D.C. United Login / Register Search Cart (0)
Official Hampton Roads Soccer Affiliate of D.C. United
Fan and Group Experiences
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SECURE YOUR SEATS FOR 2019
Tickets on Sale Now
Reviewing Virginia Beach City FC's Successful 2019 Season
Virginia Beach City FC rebounded this season, finishing with a 6-1-1 regular season record and qualifying for the NPSL Mid-Atlantic Conference Championship.
That wasn't the organization's only accomplishment this season, as VB City FC successfully made the move to a new venue, orchestrated several shutouts and cemented themselves as one of the best teams in the entire NPSL.
FC Baltimore Pushes Past Virginia Beach City FC in Extra Time to Win NPSL Mid-Atlantic Title
Virginia Beach City FC fell just short of their ultimate goal this season, losing to FC Baltimore Christos 1-0 in extra time in the NPSL's Mid-Atlantic Conference Championship.
Know Your Opponent: FC Baltimore-Christos | 7.6.19
Virginia Beach City FC is playing for all of the marbles on Sat., July 6 vs. FC Baltimore in the NPSL Mid-Atlantic Conference Championship. FC Baltimore will host the match, thanks to a head-to-head tiebreaker.
TO UNITE OUR CITY THROUGH THE WORLD'S GAME
Virginia Beach City FC continues to unite the Hampton Roads community through the sport of soccer. Our loyal season ticket holders and supporters are the pulse behind the electric atmosphere at Virginia Beach City FC matches and the teams desire to win championships. Help us keep the momentum going. Join us today.
News: D.C. United Talent Center for Hampton Roads, VA
D.C. United Winter Talent Center Dates Released - Hosted by Virginia Beach City FC
VIRGINIA BEACH, Va. (Dec. 13, 2018) — Virginia Beach City FC's MLS partner, D.C. United, has announced their Winter Training Center dates in the Hampton Roads area, hosted by VB City FC. You do not have to be a VB City FC Academy player to participate.
D.C. United Name Brian Hinkey Head Scout of Hampton Roads Metro | D.C. United
Virginia Beach City FC and D.C. United have named Brian Hinkey as the Head Scout of the Hampton Roads, VA metropolitan region, the clubs announced today.
BOYS TRYOUTS: Summer Academy Pro Experience | D.C. United Academy Exhibition Match & Talent Center
Virginia Beach City FC will offer Spring Open Tryouts giving players an opportunity to earn a roster position as the club's First Team coaching staff continues to builds their rosters for the 2018 Virginia Beach City FC Summer Academy Pro Experience™.
This program will also serve as an official talent center for D.C. United featuring a match with D.C. United Academy and identification opportunities specifically with the D.C. United Scout for Hampton Roads.
WEAR OUR COLORS, REP YOUR CLUB
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News: Youth Development Academy
Virginia Beach City FC Academy Joins US Youth Soccer EDP National League and EDP Conferences Starting Fall 2019
Virginia Beach City FC Academy will become EDP's newest member in the Commonwealth of Virginia competing in the South Atlantic Conference.
Virginia Beach City FC Supports Youth Soccer With 2nd Hosted Tournament in 5 Months
VIRGINIA BEACH, Va. (March 4, 2019) — As a part of the club's continued mission to support the development of youth soccer and grow the game both locally and regionally, Virginia Beach City FC hosted the first ever MLDA Cup this past weekend on March. 2 and 3. Congratulations to all 40 teams that participated in the very first MLDA Cup!
Virginia Beach City Hosting First MLDA Cup in March 2019
VIRGINIA BEACH, Va. (Feb. 10, 2018) — Virginia Beach City FC is hosting the first annual Major League Development Association (MLDA) Cup next month, a tournament destined to provide an opportunity for local and regional players to be scouted by coaches across the competitive spectrum.
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redpajama_set_name: RedPajamaCommonCrawl


text:
CampaignFeedServiceでは、キャンペーンのFeedItem情報の取得および更新を行います。
#### WSDL
| environment | url |
|---|---|
| production  | https://ss.yahooapis.jp/services/V201909/CampaignFeedService?wsdl|
| sandbox  | https://sandbox.ss.yahooapis.jp/services/V201909/CampaignFeedService?wsdl|
#### Namespace
http://ss.yahooapis.jp/V201909/CampaignFeed
#### サービス概要
キャンペーンのFeedItem情報の取得およびFeedItem情報の追加・更新・削除を行います。
#### 操作
CampaignFeedServiceで提供される操作を説明します。
+ [get](#get)
+ [mutate(SET)](#mutateset)

#### オブジェクト
[CampaignFeed](../data/CampaignFeed)

## get
キャンペーンのFeedItem情報を取得します。

#### リクエスト
| パラメータ | 必須 | データ型 | 説明 |
|---|---|---|---|
| selector | ○ | [CampaignFeedSelector](../data/CampaignFeed/CampaignFeedSelector.md) | 操作の対象とするFeedItem情報です。 |

##### <リクエストサンプル>
```xml
<SOAP-ENV:Envelope xmlns:SOAP-ENV="http://schemas.xmlsoap.org/soap/envelope/">
  <SOAP-ENV:Header>
    <RequestHeader xmlns="http://ss.yahooapis.jp/V201909/CampaignFeed" xmlns:ns2="http://ss.yahooapis.jp/V201909">
      <ns2:license>1111-1111-1111-1111</ns2:license>
      <ns2:apiAccountId>2222-2222-2222-2222</ns2:apiAccountId>
      <ns2:apiAccountPassword>password</ns2:apiAccountPassword>
    </RequestHeader>
  </SOAP-ENV:Header>
  <SOAP-ENV:Body>
    <get xmlns="http://ss.yahooapis.jp/V201909/CampaignFeed" xmlns:ns2="http://ss.yahooapis.jp/V201909">
      <selector>
        <accountId>1234567890</accountId>
        <campaignIds>10001</campaignIds>
        <campaignIds>10002</campaignIds>
        <campaignIds>10003</campaignIds>
        <campaignIds>10004</campaignIds>
        <campaignIds>10005</campaignIds>
        <feedItemIds>20001</feedItemIds>
        <feedItemIds>20002</feedItemIds>
        <feedItemIds>20003</feedItemIds>
        <feedItemIds>20004</feedItemIds>
        <feedItemIds>20005</feedItemIds>
        <placeholderTypes>QUICKLINK</placeholderTypes>
        <placeholderTypes>CALLEXTENSION</placeholderTypes>
        <placeholderTypes>CALLOUT</placeholderTypes>
        <placeholderTypes>STRUCTURED_SNIPPET</placeholderTypes>
        <paging>
          <ns2:startIndex>1</ns2:startIndex>
          <ns2:numberResults>100</ns2:numberResults>
        </paging>
      </selector>
    </get>
  </SOAP-ENV:Body>
</SOAP-ENV:Envelope>
```

#### レスポンス
| フィールド | データ型 | 説明 |
|---|---|---|
| rval | [CampaignFeedPage](../data/CampaignFeed/CampaignFeedPage.md) | 取得されるキャンペーンのFeedItem情報のエントリーです。 |

##### <レスポンスサンプル>
```xml
<SOAP-ENV:Envelope xmlns:SOAP-ENV="http://schemas.xmlsoap.org/soap/envelope/">
  <SOAP-ENV:Header>
    <ResponseHeader xmlns="http://ss.yahooapis.jp/V201909/CampaignFeed" xmlns:ns2="http://ss.yahooapis.jp/V201909">
      <ns2:service>CampaignFeed</ns2:service>
      <ns2:requestTime>1547793122657</ns2:requestTime>
      <ns2:timeTakenSeconds>0.2671</ns2:timeTakenSeconds>
    </ResponseHeader>
  </SOAP-ENV:Header>
  <SOAP-ENV:Body>
    <ns2:getResponse xmlns="http://ss.yahooapis.jp/V201909" xmlns:ns2="http://ss.yahooapis.jp/V201909/CampaignFeed">
      <ns2:rval>
        <totalNumEntries>1</totalNumEntries>
        <Page.Type>CampaignFeedPage</Page.Type>
        <ns2:values>
          <operationSucceeded>true</operationSucceeded>
          <ns2:campaignFeedList>
            <ns2:accountId>1234567890</ns2:accountId>
            <ns2:campaignId>10001</ns2:campaignId>
            <ns2:placeholderType>QUICKLINK</ns2:placeholderType>
            <ns2:campaignFeed>
              <ns2:accountId>1234567890</ns2:accountId>
              <ns2:campaignId>10001</ns2:campaignId>
              <ns2:feedItemId>20001</ns2:feedItemId>
              <ns2:placeholderType>QUICKLINK</ns2:placeholderType>
            </ns2:campaignFeed>
            <ns2:devicePlatform>DESKTOP</ns2:devicePlatform>
          </ns2:campaignFeedList>
        </ns2:values>
      </ns2:rval>
    </ns2:getResponse>
  </SOAP-ENV:Body>
</SOAP-ENV:Envelope>
```

## mutate(SET)
キャンペーンにFeedItem情報を追加・更新・解除(削除)します。
* FeedItem情報を解除するときは空の情報で更新します。
* 1つのキャンペーンに設定できるFeedItem情報は、QUICKLINKS、CALLEXTENSIONでそれぞれ20件までです。
* CALLEXTENSIONについて1キャンペーンあたり1件の設定をお薦めします。
* 1リクエスト内で同一のcampaignIdに複数のFeedItem情報は設定できません。

#### リクエスト
| パラメータ | 必須 | データ型 | 説明 |
|---|---|---|---|
| operations | ○ | [CampaignFeedOperation](../data/CampaignFeed/CampaignFeedOperation.md) | 操作の対象とするキャンペーンのFeedItem情報および操作の内容を表します。
 FeedItem情報は上書きされます。
FeedItem情報の設定を解除するときは空のデータで更新してください。 |

##### <リクエストサンプル>
```xml
<SOAP-ENV:Envelope xmlns:SOAP-ENV="http://schemas.xmlsoap.org/soap/envelope/">
  <SOAP-ENV:Header>
    <RequestHeader xmlns="http://ss.yahooapis.jp/V201909/CampaignFeed" xmlns:ns2="http://ss.yahooapis.jp/V201909">
      <ns2:license>1111-1111-1111-1111</ns2:license>
      <ns2:apiAccountId>2222-2222-2222-2222</ns2:apiAccountId>
      <ns2:apiAccountPassword>password</ns2:apiAccountPassword>
    </RequestHeader>
  </SOAP-ENV:Header>
  <SOAP-ENV:Body>
    <mutate xmlns="http://ss.yahooapis.jp/V201909/CampaignFeed">
      <operations>
        <operator>SET</operator>
        <accountId>1234567890</accountId>
        <operand>
          <accountId>0</accountId>
          <campaignId>10001</campaignId>
          <placeholderType>QUICKLINK</placeholderType>
          <campaignFeed>
            <feedItemId>20001</feedItemId>
          </campaignFeed>
          <devicePlatform>DESKTOP</devicePlatform>
        </operand>
      </operations>
    </mutate>
  </SOAP-ENV:Body>
</SOAP-ENV:Envelope>
```

#### レスポンス
| フィールド | データ型 | 説明 |
|---|---|---|
| rval | [CampaignFeedReturnValue](../data/CampaignFeed/CampaignFeedReturnValue.md) | 操作結果を含むキャンペーンのFeedItem情報のコンテナです。 |

##### <レスポンスサンプル>
```xml
<SOAP-ENV:Envelope xmlns:SOAP-ENV="http://schemas.xmlsoap.org/soap/envelope/">
  <SOAP-ENV:Header>
    <ResponseHeader xmlns="http://ss.yahooapis.jp/V201909/CampaignFeed" xmlns:ns2="http://ss.yahooapis.jp/V201909">
      <ns2:service>CampaignFeed</ns2:service>
      <ns2:requestTime>1547793122716</ns2:requestTime>
      <ns2:timeTakenSeconds>0.2671</ns2:timeTakenSeconds>
    </ResponseHeader>
  </SOAP-ENV:Header>
  <SOAP-ENV:Body>
    <ns2:mutateResponse xmlns="http://ss.yahooapis.jp/V201909" xmlns:ns2="http://ss.yahooapis.jp/V201909/CampaignFeed">
      <ns2:rval>
        <ListReturnValue.Type>CampaignFeedReturnValue</ListReturnValue.Type>
        <Operation.Type>SET</Operation.Type>
        <ns2:values>
          <operationSucceeded>true</operationSucceeded>
          <ns2:campaignFeedList>
            <ns2:accountId>1234567890</ns2:accountId>
            <ns2:campaignId>10001</ns2:campaignId>
            <ns2:placeholderType>QUICKLINK</ns2:placeholderType>
            <ns2:campaignFeed>
              <ns2:accountId>1234567890</ns2:accountId>
              <ns2:campaignId>10001</ns2:campaignId>
              <ns2:feedItemId>20001</ns2:feedItemId>
              <ns2:placeholderType>QUICKLINK</ns2:placeholderType>
            </ns2:campaignFeed>
            <ns2:devicePlatform>DESKTOP</ns2:devicePlatform>
          </ns2:campaignFeedList>
        </ns2:values>
      </ns2:rval>
    </ns2:mutateResponse>
  </SOAP-ENV:Body>
</SOAP-ENV:Envelope>
```

この 作品 は クリエイティブ・コモンズ 表示 - 改変禁止 2.1 日本 ライセンスの下に提供されています。

redpajama_set_name: RedPajamaGithub


The National Center on Elder Abuse reports that between one and two million elderly adults have suffered from some form of elder abuse. While cases of elder abuse do occur in nursing homes, most elders are abused in their home or in the home of a family caregiver. Several risk factors can help you identify if elder abuse is happening to someone you know.
Elder abuse happens when a mentally and/or physically frail individual is unable to stand up to physical, emotional, financial, verbal or sexual abuse. Typically elders are abused by family members or friends who are responsible for their care. But sometimes elder abuse does happen in institutionalised settings like nursing homes and other long-term-care facilities.
Elder abuse includes physical, emotional and sexual abuse. Neglect or abandonment, financial exploitation and health-care fraud are also forms of elder abuse. HelpGuide.org reports that over half of all reported elder abuse cases include neglect or abandonment, which involves caregivers failing to perform caregiving tasks.
Some risk factors to watch for in caregivers include depression, drug or alcohol abuse, lack of support from family or friends and an inability to cope with stress. In addition, the condition and circumstances of the elderly adult can increase your awareness of potential elder abuse situations. For instance, if your loved one has dementia, a history of domestic violence or extreme social isolation where he is often alone with the caregiver, watch for signs of elder abuse.
If you suspect elder abuse, do not let it continue. The safest way to report elder abuse is to consult with a trusted family member or friend and to tell a doctor. Many states and organisations have toll-free hot lines available to call if you think abuse may be occurring.
Elder abuse happens, but it doesn't need to. If you have elderly parents or loved ones, familiarise yourself with the risk factors surrounding elder abuse. By knowing the signs, you may be able to stop abuse before it becomes a problem. Don't let the fear of family members, friends or medical professionals stop you from doing the right thing.


People's Deputies of Ukraine have begun to knopkodavit in parliament in the first working day after vacation.
Journalists of NEWSONE TV channel have recorded two moments when people's deputies voted for other people's deputies: during vote for the bill No. 6085 of cross-border cooperation and also during vote for the agenda the current week.
So, on "Popular front" has voted for the colleagues Podbereznyak Vadim. He has pressed the green buttons instead of Alexander Gorbunov, Georgy Logvinsky and Pavel Pinzenik.
Other People's Deputy from the same fraction - Ivanchuk Andrey - during vote for the agenda the current week has voted for Victor Elensky, Svetlana Voytsekhovskaya, Maxim Polyakov and Pavel Pinzenik. We will notice that Victor Elensky and Svetlana Voytsekhovskaya were present at the workplaces before and participated in vote.
as a result after three unsuccessful attempts the bill No. 6085 have supported 234 People's Deputies. Also the agenda the current week was accepted after several unsuccessful attempts. 241 deputies have voted pro.


Kan–geiko is a traditional training at the coldest time of the year, and through overcoming this hardship we start the New Year in the right spirit. Gothenburg Aikido Club has been organizing this New Year event for almost 30 years. Aikidoka from all over the world have been coming to practice Takemusu Aikido under the supervision of Ulf Evenås Shihan.
Ulf-sensei will teach Takemusu Aikido, as learned directly from Morihiro Saito Shihan as his close student for 29 years.In 2019 Ulf sensei has been training Iwama Takemusu Aikido for 50 years! He will teach ken and jo, as described by Morihiro Saito Shihan in the five Mokuroku (transmission scrolls), and it´s variations, taijutsu from basic forms to ki no nagare, and explore the relationship (riai) between ken, jo and taijutsu.
The seminar is open to everyone, regardless of rank or "style." Meet aikidoka from other countries, meet old friends and make new, and practice Aikido in the spirit of Morihiro Saito Shihan. The event will take place at Frolunda Judo Club, with 360 square meters of tatami, with a fully equipped kitchen. It is walking distance to a big shopping center, and the public transportations to the central part of the city are excellent.
Following the seminar, there will be an Uchideshi week at Gothenburg Aikido Club, taught by top students of Ulf Evenås Shihan – Dan Borg 6 dan, Günter Annby 5 dan, Marijan Sprem 5 dan (all from Gothenburg Aikido Club), Johnny Sørensen 5 dan (Aalborg, Denmark), and Edgaras Indra 5 dan (Kaunas, Lithuania) will be teaching. Don't miss this opportunity to practice with, and get to know, the new generation of international top instructors.
Frölunda Judo Club, Klubbvägen 8, Västra Frölunda.
900 SEK (€ 100). Two days 600 SEK (€ 70) Payment before first training.
Party: 160 SEK (€ 20). Notify participation when you register.
Please inform us of any food restrictions, e.g. vegetarian, vegan, or other food intolerances.
Frölunda Judo Club: 75 SEK (€ 10) per night. Bring sleeping bag.
Gothenburg Aikido Club: 60 SEK (€ 6) per night. Bring sleeping bag.
Bring bokken and jo. Participants traveling by airplane can borrow weapons.
during the sessions is forbidden without permission.
Uchideshi week It will be held at Gothenburg Aikido Club. For further information, see website & Facebook.
Ulf Evenås is a 7th dan Aikikai Shihan. He also received 7th dan and was appointed Shihan (Takemusu Aikido) directly from Morihiro Saito Shihan, who also appointed Ulf-sensei as his personal representative. He also has a full teaching certification in Bukiwaza, the fifth level of the Mokuroku (transmission scrolls).
Ulf-sensei is the head instructor of the Gothenburg Aikido Club, and one of the most qualified, and experienced, Aikido teachers in the world. The International Aikido Federation (IAF) uses Ulf Evenås as their representing Shihan, technical coordinator and demonstrator in major events such as IAF:s Congress and World Combat Games. Ulf-sensei has been teaching 800 seminars in 25 countries worldwide.
Gothenburg Aikido Club started as a small group of enthusiasts in the late 1960's, under the leadership of Carl Hansson (1910–1996). In 1969 the group became more organized and the same year it began with Iwama Takemusu Aikido, introduced by sensei Takeji Tomita. With 50 years of experience in Iwama Aikido, Gothenburg Aikido Club is the oldest existing Iwama "style" dojo outside Japan.


Philly's Pissed set out to be a group by women for women.
Maybe this is what makes Pissed Off so readable and relatable.
Mattie Weiss, is the Midwest organizer for the League of Pissed Off Voters, a contributor to How to Get Stupid White Men Out of Office and the author of Youth Rising, a national research report on youth organizing.
He's still pissed, and he's not sure how not to keep being pissed," the actor said, as per (http://www.
'Legends Of Tomorrow': Is Mick Rory Getting A Love Interest In Season 2?
When one person just wants a divorce and the other one is just pissed, they try to make it so difficult," she added.
Emily Stowe (1831-1903), Canada's first practising female doctor, pissed off a whole ton of people.
So John's talking to the guys, and says, "How funny would it be if I went and pissed on the ledge?
Sierra Fellers: "i'm through being nice"
If the greatest generation had landed at Omaha Beach, pissed themselves, tossed their weapons into the sea, and begged to serve as Nazi slop boys, then you might have an equivalent act of mass cowardice.
TV chef Keith Floyd issued this Christmas message yesterday after being banned from driving for crashing his car while more than three times the limit: 'Get pissed at home - don't drive.
More people might turn up if there is the possibility of getting pissed.
I'm pissed,'' said Jami Manning, 22, of Oakland, who sang Alicia Keys' ``Fallin''' but didn't make the cut.
Carlin: It's all right for one guy to say, "why are you pissed off at me?
Early on, one fighter pilot told Wilson that "if you don't fly for two or three days on a ship, you start to get irritable, pissed off.
I'm sure he was getting pissed," said Whamond who was seated in Section 86, Row 2.
Residents reported that he pissed "JB" in the snow.


text:
3D Printing Captures the Aerospace and Space Market
The Norwegian based company Norsk Titanium AS (NTi) has developed a plasma-arc-based direct metal deposit technology that can produce aerospace-grade parts from titanium wire.
Complicated engine constructions for airplanes and space applications are mostly cut from large blocks of metal, a slow and demanding material, not to mention an expensive method, however, 3D printing of such constructions will prove to revolutionize these constructions. This method has been under development for many years, however, the high quality demands special types of material, and the aerospace industry naturally requires and demands nothing but the best, consequently, the demands are hard to face up to. Nevertheless, the market many now finally open up to new technology.
Norsk Titanium (NTi) has gained a good foothold within the aerospace industry through development of very hopeful methods of printing of constructions in titanium. Titanium is, together with carbon fibre, two new materials that have revolutionized the aircraft industry, titanium in the engines and carbon fibre in the fuselage.
The technique is developed at NTi's own plant in Norway, but in a partnership with the state of New York they will build a dedicated production facility north of the state's capital city, Albany. Investing nearly 125 million dollars, New York has decided to be a part in this venture . The facility will be built and owned by the state, but leased and operated by NTi. The capacity will be 1,000 tons of titanium parts a year by 2018.
Revolutionize the Material and Time Consume
Engine parts very suitable for 3D printing. Credit: NordicSpace
For traditional production the weight ratio between the raw material to the finished part is very high and the machining process is very expensive. However, the printing of near-net parts the process will eliminate 70-75% of the cost. A printed raw product is quite similar to the final product and the remaining process is nearly only a finishing touch. The same is true for the time consummation, however, the difference in cost and time together, between old and new methods, the savings will have a ratio of 10-20 to 1. The cost savings for one aircraft producer will immediately force others to use the same method and the market will expand very quickly.
The market is rather big. In a Boeing 787 it is estimated that there are 1000 parts in Titanium. It is also estimated a cost saving at 2,500 dollars per part, or 2.5 million dollars per aircraft, nearly an industrial revolution.
The new methods is developed by the Norwegian based company Norsk Titanium AS, and the company now has to produce nearly 2000 parts for the test. The unique production machinery is mainly developed by the Norwegian Tronrud Engineering AS and the company is also chosen to deliver the parts and machinery for the commercial production, but first of all the main goal now is primarily to produce three machines for the test production.
To the American periodical "Aviation Week and Space Technology", president and GEO Warren Boley, pointed out that the new facility will be able to produce 1000 tons of titanium parts in 2018. Furthermore, he stated: "You can take a 200-lb. forging and produce a 20 lb part. We can print 30 lb of material and produce a 20 lb part. Components produced only require the finishing touches of machining.
Norsk Titanium AS
Norsk Titanium AS (NTi)is a global leader in manufacturing performance critical titanium components for aerospace and industrial applications. The company has revolutionized the industry with the patented Direct Metal Deposition (DMD) technology that transforms titanium wires into complex components at better than half the time and cost, as well as waste levels of legacy processes. www.norsktitanium.no
Tronrud Engineeing AS
About Tronrud Engineering AS
Tronrud Engineering AS is a leading provider of cutting-edge technologies in developing and manufacturing advanced machinery, given its customers competitive advantages and profitability. Established in 1977 by Ola Tronrud, the company has more than 175 employers in Norway and Singapore. www.tronrud.no
Not only in Titanium.
3D printing, also known as additive manufacturing is a process to make three-dimensional objects. The process is known as far back as from the early eighties in the previous century. In 3D printing additive processes are used, in which successive layers are laid down under computer control. These products can have nearly almost any shape and geometry. The object can be further machined and finished to the final product. The method has been in constant development and has captured new markets, now also the aerospace market. However, in the Nordic countries several additional industrial companies are currently developing new products.
The Finnish VTT Technical Research Centre of Finland has in cooperation with an industrial partner developed a hydraulic valve block that is 66 % lighter than a traditional block.
SINTEF, Norway's largest research institute, coordinates a EU research programme aimed to begin within the year 2020 to develop 3D printing technology for production of chemical reactors. Traditional machining has a practical limit for how complicated a reactor can be. Using 3D printing, one hopes the limits can be further pushed.
Featured image.
A complete aircraft engine. Many of the parts is well suitable for 3D printing and mechanical finishing. Credit: Nordicspace


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At least Brewers signal spring
Jon Gast column
At least Brewers signal spring Jon Gast column Check out this story on greenbaypressgazette.com: http://gbpg.net/2nTGdDZ
USA TODAY NETWORK-WISCONSIN Published 10:57 a.m. CT April 4, 2017
Jon Gast
The advent of baseball season is unlike any other in major professional sports.
Football, basketball and hockey all begin after Labor Day or into fall. Certainly, a beautiful time of the year but also one that slowly descends into the colder days of winter.
Baseball, on the other hand, signals the beginning of spring and regardless of the prospects for your favorite team there is the enjoyment of knowing that at least the losing will take place during the most comfortable time of the year.
Many baseball prognosticators think that will be the case around Miller Park this season and that's fine because Wisconsin sports fans don't really need a good team to have a great time.
Unfortunately, many of those forecasters are right. Milwaukee will lose more games then it will win in 2017. Lately, each time you get one of these ominous predictions it tends to come with a silver lining. They preface their remarks by reminding everyone that this a rebuilding club that has done a solid job of restocking its farm system and what fans need more than anything is patience. Some solid pitching wouldn't hurt, either.
I know there are quite a few Brewers fans out there who see this season in much the same way as they see parents measuring the height of their child on a door frame — a slow but steady climb until they can beat dad one-on-one in driveway hoops.
But pro sports don't always work that way. There are too many other factors that go into a team's growth and many can short circuit the desired outcome. Effective team management may be the most important and probably best explains why bottom feeders stay bottom feeders.
Say what you want about the Packers' Ted Thompson, and people always seem to have something to say, but the team keeps winning.
We don't quite yet know about Milwaukee General Manager David Stearns.
Well, one thing we know is that he's young. So young it wouldn't surprise me if the equipment guy keeps handing him gear on the first day of practice. But every time his age begins to bother me, I watch the movie Moneyball. I've seen it a few times and try to convince myself that the Brewers can have the same Hollywood ending.
Unfortunately, I don't think the script calls for it this year. The cast has few veteran actors but it's tough to draw much critical acclaim with an over abundance of interns. Look down the credits and you'd swear some of the production crew was also appearing in this film, especially the mound scenes.
But will the Brewers produce some performances worthy of Oscar consideration. They still have Ryan Braun — who could easily end up leaving this off-Broadway production for the big lights of Broadway.
I see the Brewers solid up the middle with Orlando Arcia at shortstop and Jonathan Villar at second base. The outfield has some emerging talent in the minors so don't be surprised if Braun ends with a role change to first base to help make room for it all. Especially, if the odd pick-up of Eric Thames from Korean ball doesn't pan out.
Junior Guerra and Zach Davies could have solid years on the mound but that's about it and now Guerra is sidelined by injury.
Bottom line, another similar script — a fourth-place finish behind the Cubs, Cardinals and Pirates in the National League Central and a couple more wins than the 73 last year.
Jon Gast writes a weekly sports column for the Advocate. He can be reached by email at jsgast@gmail.com
Read or Share this story: http://gbpg.net/2nTGdDZ


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In Vivo 7-Tesla MRI Investigation of Brain Iron and Its Metabolic Correlates in Chronic Schizophrenia
Schizophrenia (Heidelb). 2022 Oct 26;8(1):86. doi: 10.1038/s41537-022-00293-1.
Parsa Ravanfar 1 2 , Warda T Syeda 3 , Mahesh Jayaram 4 , R Jarrett Rushmore 5 6 7 , Bradford Moffat 8 , Alexander P Lin 5 9 , Amanda E Lyall 5 10 11 , Antonia H Merritt 3 , Negin Yaghmaie 8 12 , Liliana Laskaris 3 , Sandra Luza 3 13 , Carlos M Opazo 13 , Benny Liberg 14 , M Mallar Chakravarty 15 16 17 , Gabriel A Devenyi 15 16 , Patricia Desmond 18 , Vanessa L Cropley 3 , Nikos Makris 5 6 , Martha E Shenton 5 , Ashley I Bush 13 , Dennis Velakoulis 3 19 , Christos Pantelis 20 21
1 Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, Australia. sravanfar@student.unimelb.edu.au.
2 Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. sravanfar@student.unimelb.edu.au.
3 Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, Australia.
4 Department of Psychiatry, The University of Melbourne and Melbourne Health, Parkville, Australia.
5 Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
6 Center for Morphometric Analysis (CMA), Massachusetts General Hospital, Charlestown, MA, USA.
7 Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA.
8 Melbourne Brain Centre Imaging Unit, Department of Radiology, University of Melbourne, Parkville, VIC, Australia.
9 Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
10 Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
11 Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
12 Department of Biomedical Engineering, The University of Melbourne, Parkville, VIC, Australia.
13 Melbourne Dementia Research Centre, The Florey Institute of Neuroscience & Mental Health, and The University of Melbourne, Parkville, VIC, Australia.
14 Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
15 Cerebral Imaging Center, Douglas Research Centre, Montreal, QC, Canada.
16 Department of Psychiatry, McGill University, Montreal, QC, Canada.
17 Department of Biomedical Engineering, McGill University, Montreal, QC, Canada.
18 Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.
19 Neuropsychiatry, The Royal Melbourne Hospital, Parkville, VIC, Australia.
20 Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, Australia. cpant@unimelb.edu.au.
21 The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia. cpant@unimelb.edu.au.
Brain iron is central to dopaminergic neurotransmission, a key component in schizophrenia pathology. Iron can also generate oxidative stress, which is one proposed mechanism for gray matter volume reduction in schizophrenia. The role of brain iron in schizophrenia and its potential link to oxidative stress has not been previously examined. In this study, we used 7-Tesla MRI quantitative susceptibility mapping (QSM), magnetic resonance spectroscopy (MRS), and structural T1 imaging in 12 individuals with chronic schizophrenia and 14 healthy age-matched controls. In schizophrenia, there were higher QSM values in bilateral putamen and higher concentrations of phosphocreatine and lactate in caudal anterior cingulate cortex (caCC). Network-based correlation analysis of QSM across corticostriatal pathways as well as the correlation between QSM, MRS, and volume, showed distinct patterns between groups. This study introduces increased iron in the putamen in schizophrenia in addition to network-wide disturbances of iron and metabolic status.
© 2022. The Author(s).
R01MH112748/U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
1 K01 MH115247-01A1/U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
1K24MH110807-01A1/U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
K24MH116366/U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
5 U01MH109977/U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
GIA-030H2016/Royal Melbourne Hospital (RMH)
1177370/Department of Health | National Health and Medical Research Council (NHMRC)
R01AG042512/U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging)
R21DA042271/U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA)


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The production of Nivalli's sausages and meat delis is done in the charming Dniester Valley. We have designed this factory to be able to bring back the taste of the traditional meat products. Our specialists combine these tastes of the past with the quality standards of the present, resulting products that should be on everyone's table.
Built to fully respect European standards, the Nivalli factory is a model of combining modern with traditional. All the processing equipment is brought from Austria and Germany, countries with a developed meat processing machinery industry. Nivalli incorporates the quality into the process, which ensures that each person involved is responsible for the quality of the operations performed across the entire value chain.
Since 2010, Nivalli meat and processed meat company has strived in becoming both a meat product manufacturer, but also a trusted partner. Beyond all, Nivalli's goal is to bring genuine and authentic meat products to the market. Thus, we have created a Distribution Department responsible to ensure that Nivalli products are delivered to stores in different locations in time, while respecting the Nivalli quality standard. The same department checks the storage and the delivery of the products to ensure that everything is done according to the quality rules and regulations.
On your table, we bring top-quality products only.
Nivalli is expanding its commercial network by opening new specialized stores. Thus, we are open to new long-term collaborations with trusted economic agents. If you own a store or a commercial network and you want to sell the best salamis and meat products in Moldova, we are open to collaborations.
From the opening of the factory in 2010 to the present days, we have been in a constant quest for excellence in the field of meat products. Beyond experience, we are always looking to find innovation in the sausage production. Our differentiators are the quality of our products, the speed with which we deliver our products, and the quality of the services. Daily we produce more than a hundred kinds of meat products, amazing meat delis that are taking further the Moldovan traditions.
At Nivalli we only use local products, as we believe in developing the local community. Also, we believe in the value of the local products. So, we select quality products from trusted producers that have proven their experience and capacity to deliver.
All the meat used in the Nivalli factory is rigorously tested and selected to ensure that we only sell top products that will transform your meals into real feasts.
These certifications reiterate our dedication and desire to offer great meat products. Every day we produce hundreds of salamis, safalades and other meat delis, all certified products, specially crafted for meat lovers everywhere.
Life has a taste, taste has a name - Nivalli!
At Nivalli, we only use quality meat, carefully selected and analysed to create delicious and healthy meat products.
The smoking process gives the meat that specific taste, but also the colour that our customers are looking for. Smoking prevents the formation of harmful bacteria in the meat, allowing it to be stored longer.
Nivalli's distribution network is spread all across Moldova. You can also become a Nivalli partner and distributor. Contact us now!


You may not be big on New Year's resolutions, but for those without an updated resume, it's something to consider. Why? Because whether you've made it through your whole career without ever putting one together, or you've been using the same resume you made a decade ago, having an updated resume for the current career landscape can pay back in dividends.
The truth is, a resume is not only a marketing piece that precedes your presence in an interview. It's also a building block for all other personal marketing efforts you may do throughout your career. Whether it's at a networking event or a speaking engagement, having prepared credentials that advertise your value successfully is crucial.
Keywords – You may have heard about Applicant Tracking Systems or Software (ATS), so you may be aware that almost 75% of recruiters and hiring managers use this technology to vet their candidates [Capterra]. In recruitment, a crucial part of the process is elimination, so ATS (and the initial resume scanning process in general) are meant to weed out candidates that don't meet the basic criteria. In a world of brevity and light speed efficiency, eyes and computers are looking at your resume for key words that define basic qualification for a position. Ensuring that relevant key words appear throughout your resume, and especially in the first third of the document, give you a better chance of dodging this (potentially big) hurdle.
SHOW and Tell – This may seem obvious, but a resume is meant to market your value, and the best way to do that is to offer proof of any claims you make to your expertise. It's good to have descriptors and definitions of your experience, qualifications, and skills, but at the end of the day, what holds you above the rest are the examples you are able to give of HOW this translates into value. You may be the 100th guy in line with "MBA" next to his name, but you are likely the only one who mitigated a work culture crisis by implementing a cooking competition among coworkers that improved turnover rates by 50% in one month. Quantifiable, impressive, and creative accomplishments SHOW employers that you not only have the credentials but the credibility to back up your claims.
Pay Attention to Design – I still advise clients to be careful with design elements in a resume, though there are contexts in which a colorful, graphically detailed document can be beneficial. Overall, however, keeping things clean, simple and organized is the best strategy. However, we live in a digital and visual world, and a little creativity with formatting and fonts can help the look and feel of your document. Some fonts, although easy to read and traditionally used, can feel a bit stale. Modern typography has expanded options dramatically, with slight variations on the old standards. Playing with columns, white space, or colourful lines can give your resume a unique appeal without detracting from the content (and content is always king).
Know your Unique Selling Proposition, and Use It – Having a USP is probably the most beneficial element of a resume in terms of it serving as a building block for further branding. Creating one sentence that concisely outlines who you are and what you bring to the table and then including that under your headline gives the reader a quick snapshot of what you will further defend throughout the document – a powerful tool when you consider that the average time a recruiter initially scans a resume is 8 seconds. Once you have your USP you can transfer this to your elevator pitch at networking events, opening paragraphs of cover letters, social media profile summaries, and the like.
Edit – It's still as crucial as ever to eliminate spelling errors and punctuation mistakes from a resume, but it's becoming increasingly important to edit the content. You don't want to reveal every detail of your career, or even every position, if leaving out details presents a more powerful argument. Keeping in mind potential red flags, like gaps in your work history, editing out some information can be as important as making sure others are included.
If anything, having an up to date resume on hand gives you confidence. It is evidence on paper, in a professional and "official" context, that you are valuable. And certainly that, in itself, has value.


Orders for Taiwan's exports in June probably contracted for the 15th straight month, as sluggish global demand continued to hit the island's technology products, a Reuters poll showed.
[TAIPEI] Orders for Taiwan's exports in June probably contracted for the 15th straight month, as sluggish global demand continued to hit the island's technology products, a Reuters poll showed.
Twelve economists surveyed forecast export orders would contract for the 15th month in a row, but at a slightly slower pace than in May.
The Ministry of Economic Affairs had said orders would remain negative in June even though it estimated that the value of orders should exceed May's levels.
Leading indicators, however, pointed to output expanding for the first time in three months as new export orders grow for the first time in six months. The Nikkei/Markit Taiwan Purchasing Managers' Index for June rose to 50.5 versus 48.5 in May.


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Visiting Researchers: University of Birmingham
Wednesday 4 Apr 2018 Thursday 12 Apr 2018
The Digital Studio is excited to have two researchers visiting from the Department of English Literature at the University of Birmingham, Dr Matt Hayler and Vicki Williams. Matt and Vicki will be based in the Digital Studio and are keen to connect with local researchers and students interested in the digital humanities.
Dr Matt Hayler
Matt is a lecturer in post-1945 Literature in the Department of English Literature. His research interests focus on e-reading, materially experimental writing, digital humanities, critical theory, technology, and embodiment. He is particularly interested in how the materiality of our artefacts impacts upon our culture, daily practice, and cognition. His most recent research has been into the relationship between the ethics and artistic representation of transhuman modification of the body with technology. Beyond English Studies, his research draws on cognitive science, post- and classical phenomenology, philosophy of technology, and object-oriented ontology.
Join Matt at 4.30pm Wednesday April 11 for a special joint Digital Studio and English and Theatre Studies seminar, Wandering Bodies: Ambient Literature, Entanglements, and Embodied Cognition
Connect with Matt:
@cryurchin
M.S.Hayler@bham.ac.uk
Vicki Williams
Vicki is a doctoral researcher in the English Department at the University of Birmingham. Her research focuses on the ways identity and embodiment are captured in and through immersive virtual environments and virtual reality (VR) in particular. Her research interests include phenomenology, horror and technology, posthumanism and glitch studies. Vicki also co-convenes the PLAY/PAUSE videogame and virtual reality seminar series at the University of Birmingham.
Join Vicki at 10am Tuesday April 10 for the Graduate Seminar, Inside the Unhuman Machine: Renderings of Human Subjectivity in CGI Media Artworks
Connect with Vicki:
@vicki_will
VRW203@student.bham.ac.uk


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Reporters Committee, media organizations urge Florida lawmakers to reject bills that would undermine transparency – Reporters Committee for Freedom of the Press
01/28/16 — Contact media@rcfp.org or (202) 795-9304
The Reporters Committee for Freedom of the Press and 24 news organizations have written to Florida lawmakers urging them to reject two bills that would "substantially weaken Florida's Public Records Law" and "undermine the state's longstanding commitment to government transparency."
The bills, one in the Florida Senate (SB 1220) and the other in the House (HB 1021), propose elimination of a state law providing mandatory attorney's fees for public records requestors who are successful in cases where records are "unlawfully" withheld.
"That provision assures public records requesters that they will be able to recover costs and attorney's fees incurred in successful public records litigation, and ensures that the press and the public will not shy away from enforcing the public's right to government records and information," the letter stated. "Mandatory fee shifting provisions also create a financial incentive for state and local government officials and agencies to consistently comply with public records laws when responding to requests for access."
The letter, sent to the bill's sponsors, Sen. Rene Garcia (R-38th) and Rep. W. Gregory Steube (R-73rd), and shared with lawmakers in both chambers, noted, "This proposed shift from mandatory to permissive fee awards is not only contrary to trends at both the state and federal level, but will dissuade the public and the press from pursuing clearly meritorious public records litigation for the benefit of the public at large.
"Because members of the news media, including the undersigned organizations, necessarily depend on public records laws to obtain documents and information concerning the conduct of state and local government officials and agencies, and to keep the public informed, we are deeply troubled by the legislation being considered by you and your colleagues. We strongly urge the Florida Legislature to reject these measures."
Joining the Reporters Committee on the letter, which is posted online here, were: American Society of News Editors; The Associated Press; Association of Alternative Newsmedia; The Bradenton Herald; The Center for Investigative Reporting; Florida Today: Investigative Reporting Workshop at American University: Media Law Resource Center: The Miami Herald; MPA – The Association of Magazine Media; The National Press Club; National Press Photographers Association; Newspaper Association of America; The News-Press; Online News Association; The Orlando Sentinel; Pensacola News Journal; Radio Television Digital News Association; and Society of Professional Journalists.
About the Reporters Committee
The Reporters Committee for Freedom of the Press was founded by leading journalists and media lawyers in 1970, at a time when the nation's news media faced a wave of government subpoenas asking reporters to name confidential sources. Today it provides legal resources, and support to protect First Amendment freedoms and the newsgathering rights of journalists. Funded by corporate, foundation, and individual contributions, the Reporters Committee serves the nation's leading news organizations; thousands of reporters, editors, and media lawyers; and many more who use our online and mobile resources. For more information, go to www.rcfp.org, or follow us on Twitter @rcfp.
Filed Under: Barbara Petersen, Featured, First Amendment Foundation, Florida, Florida legislature, public records Tagged With: HB 1021, legal fees, Rep. Greg Steube, SB 1220, Sen. Rene Garcia


text: Q: Anchor element in javascript Where does the value go when an event handler assigned to an onclick event of anchor element returns any value .for example:

redpajama_set_name: RedPajamaStackExchange


A group of Camp Half Blood Campers, are made to visit the Triple G Ranch. Where They are set into groups and told to clean out the stables of the Man Eating Horses.
How many campers are going..?
Roman's I guess could be involved and I think four or Five Demigods would be enough Maybe.
So are we going to rp..?
I reckon I can get an Rp started sometime in the next couple of days.


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Spring is Spronging - I'm on the road to nowhere!
Tired this morning ... Got up around 9-10.. got sorted..
Had a lateish brekky, cornflakes, milk, brown sugar..
Had lunch, sunflower roll, ham, gherkin, mayo.. nice..
After last night I changed to X-Journal.. Its free, and it seems to have better image support.. I think I've worked out what has gone wrong with those 2 entries... Some editing will be needed to 'fix' them.. Shame LJ doesn't seem to manage itself..
Here's an attempt of a pic again.. Lets see..
Finished off a few bits this afternoon, expenses & I now have 2 faxes queued for tomorrow.
Haven't done the cleaning I wanted to start on but did get the restaurant booked for next week..
Why do some people just have the reaction on me to make me horny, and some not.. Humans are strange :) Oh well.
You and your family have ben through such an ordeal over the last few months. Our thoughts have been with u and your family each and every day. Hope u liked the pics we sent you of our visit at Swindon kite fest in ? May and meeting your dad too. Was a good day and that is what we kept hold of memories of u having fun although your health was deteriorating even then.
Lets look to the future bright skys sunny crisp days and progress in your health. Hope haemodialysis is making you feel more stable I know its a tough time just to let you know we are thinking of you.


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6,700 flagged data breaches in Ireland is second highest per capita in Europe
Hiiker makes it easier to plan multi-day hikes in Ireland and abroad
Questions to ask your general election candidates about climate action
CIT-to lead €3.8m EU project to develop next-gen sensors for drones
Entangled electrons found in 'strange metal' could boost quantum computing
Why it's better to be motivated by 'progress, not perfection'
What can your ancestry tell you about neurological diseases?
17 Jan 20181.59k Views
Gianpiero Cavalleri, associate professor of human genetics at RCSI. Still from 'Gianpiero Cavalleri'. Image: RCSI/YouTube
Gianpiero Cavalleri of RCSI outlines his work in trying to unlock medical secrets based on our ancestry.
As companies such as 23andMe have shown, many of us are fascinated about our ancestry, and the rapid advancement of cheap, accurate genetic testing has helped to find some truly surprising results.
But, aside from just learning about our family tree, researchers are now tracing our genetic history in an effort to help identify and track new diseases.
One such researcher is Gianpiero Cavalleri, associate professor of human genetics at the Royal College of Surgeons in Ireland (RCSI) and deputy director of the Science Foundation Ireland-funded FutureNeuro research centre.
After completing his bachelor's degree in genetics at Trinity College Dublin in 2000, Cavalleri travelled to California to work as a research scientist at Stanford University for two years.
After returning to Europe to undertake a PhD at University College London, he found his way back to Ireland and RCSI, where he is also the lead of the college's human genetic variation research group.
As part of the FutureNeuro SFI research centre team, Cavalleri helped to create the first fine-scale genetic map of Ireland, revealing the first evidence of 10 distinct genetic clusters on the island.
What inspired you to become a researcher?
I really love genetics; I find it incredibly interesting. I heard some lectures on the potential of genetics and I felt this was an area that could have a real impact on society.
You can really see this becoming reality today, with genetics informing on ancestry, being integrated into the clinic as a routine test and generally becoming a topic of conversation.
Can you tell us about the research you're currently working on?
We are studying genetic variability in the Irish population, and this involves looking at those points in our DNA where we differ.
We use these large datasets to resolve structure in the Irish population, and it's remarkable (but of course expected) how much that structure correlates with historical political power bases in Ireland.
We can also leverage that knowledge of population structure to help identify new disease genes and genetic changes that might be causing disease from those that are neutral. We then translate that knowledge to the clinic, and we work closely with epileptologists to help them improve how they diagnose epilepsy.
With a very accurate diagnosis – informed by DNA sequencing, for example – you have a much better idea of the underlying problem, and can then develop and select safer and more effective treatments.
So, using genetics, knowledge of our ancestors can inform us on how we are treated individually for medical conditions we experience.
Through the FutureNeuro SFI research centre, we hope to inform on more personalised treatments for neurological diseases in Ireland and further afield.
In your opinion, why is your research important?
Knowledge of genetics unlocks power for society. How it is interpreted and applied is fundamental to ensuring we reap benefit from it.
I hope our work, and the work of scientists generally, can help shape a world for our children to inherit that is safer and better.
What commercial applications do you foresee for your research?
In a commercial sense, genetics has exploded over the last three years. When I graduated with a PhD in 2006, your obvious opportunities were in academia. Now it's very much in industry, whether it's ancestry companies (see Ancestry.com for example), in diagnostics or with pharma. There is a lot happening.
Are there any common misconceptions about this area of research?
Historically, genetic concepts have been used to promote racism. The reality is that genetics has shown we are one big family, and the differences between us are tiny.
What are some of the areas of research you'd like to see tackled in the years ahead?
Genomics in cancer. There is incredible potential for genome sequencing to guide cancer therapy, where an oncologist can observe how a cancer is evolving and/or responding to treatment.
Genomic sequencing allows us to visualise cancer in a way that just wasn't possible in the past.
Who is your unsung hero of science and why?
The people who contribute their data to research studies, such as those with epilepsy who participate in our studies. Without them, the work cannot happen.
Related: genetics, RCSI, medicine, Science Uncovered
'I would like to see research looking at cancer as a chronic illness'
2 Oct 2019404 Views
There's no such thing as a 'typical day' at Genomics Medicine Ireland
'I get articles on WhatsApp with claims that a unique fruit is a cure for cancer'
Genomics Medicine Ireland is expanding its team
What made this software developer return home after 15 years?
'Everyone sees successes, but few realise you need to fail to have victories'


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Congressional Affairs | Newsroom | Speeches | NSF-Wide Investments | What's Cool | Publications | Partners | History | About Us
You are in: NSF Home > Speeches > Speeches by the Rita Colwell > Dr. Colwell's Remarks
Dr. Colwell's Remarks
Balancing The Biocomplexity of the Planet's Living Systems: A 21st Century Task for Science
Dr. Rita R. Colwell
Director-Designate
American Institute of the Biological Sciences
(As Delivered)
Good evening. I am delighted to be here. There is an old saying about how the best audiences are intelligent, well informed and a little drunk. Since the reception is after the speeches, we're batting two for three. Not bad, right?
Although we are all members of a large and proud community of researchers in the life sciences, I welcome you today in a new capacity. As the still "wet behind the ears" Director-designate of the National Science Foundation, I am acutely aware that Neal Lane leaves a legacy of vision and excellence.
These opening remarks are in part greeting and welcoming, but my intent is also to challenge all of us in the larger science community with a formidable task. I will cut to the chase. For the 21st century, our goal must be to understand, and learn to keep in balance, the "biocomplexity" of all the Earth's ecosystems.
"Biocomplexity," what do I mean by that? It may not be in our lexicon right now, but it is where we need to go in our quest to understand the Earth's biosphere.
Let me start with a bit of historical perspective. With the exception of the life sciences community, this is the first time in human history that global inhabitants are collectively beginning to recognize that the environment needs protection from humankind. For 6000 years, the pattern has been humans needing protection from nature.
Of course, we are still vulnerable. Recent tornadoes, tidal waves, and earthquakes remind us of that. Nevertheless, the planet has become vulnerable to our human power to inflict irreversible damage.
For hundreds of years people have, with abandon, depleted forests and mineral resources, polluted the air, and contaminated waterways. This trend has intensified with a burgeoning world population, coupled with the power of technology. It has escalated and accelerated alteration of the environment in ways never before possible.
The special emphasis of this meeting of AIBS is on the ecosystem of Chesapeake Bay and it has a very personal meaning for me since my husband and I are racing sailors who have spent the last twenty-five years sailing on the Bay. Jack and I just returned from meetings in England, which we combined with a visit to the Lake District, where the poet Samuel Taylor Coleridge lived.
I am reminded of Coleridge's lines from his long poem, The Rime of the Ancient Mariner, those lines that we all had to memorize in high school.
"Water, water everywhere,
And all the boards did shrink;
Nor any drop to drink. ...
The very deep did rot."
To Coleridge, in his altered state of the fantastical, this dire fate came about to avenge the death of the albatross. One nevertheless has to wonder about the insight and the imagination of Coleridge writing at the end of the 18th century.
Here we are at the end of the 20th century, roughly 200 years later. And our "water, everywhere" has the potential to become barren, useless, and even poisonous to aquatic life and inhabitants of the land. Like the ancient mariner and his crew, we would not be innocent victims, but rather societal participants.
Much like the Chinese definition of "crisis," there is both opportunity and responsibility for the science community. This is where biocomplexity takes shape as a research direction, as well as a key to social understanding. To my mind, biocomplexity reaches beyond biodiversity. When we speak of sustaining biodiversity, we mean primarily maintaining the plant and animal diversity of the planet, a very important goal.
On the other hand, the phrase "understanding biocomplexity" speaks of a deeper concept. It is not enough to explore and chronicle the enormous diversity of the world's ecosystems. We must do that ...but also reach beyond, to discover the complex chemical, biological, and social interactions in our planet's systems. From these subtle but very sophisticated interactions and interrelationships, we can tease the principles of sustainability.
I recognize that to many of you, this must sound like a "coals to Newcastle" speech, a preaching to the choir. Nevertheless, there is a purpose. This message is one we have to take to the larger science community and ultimately to the public.
On President's Clinton's recent trip to China he urged the Chinese government and the Chinese people not to make the same mistakes that other developing nations have visited on themselves. He reminded them that economic growth and environmental preservation are not mutually exclusive. As all of you know, this is a lesson we are still struggling to appreciate in America.
In my new job as NSF Director, I am learning new things about biology from very unlikely sources. Congressman George Brown of the House Science Committee, and a longtime friend of science, made an astute observation in the commencement address he delivered at UCLA in 1994. He said to the graduates:
"Not unlike the way diverse cells in multicellular biological organisms signal their activity and thus coordinate their behavior with unlike cells to ensure the survival of the organism, we as citizens need to do the same. We can learn our place and function in the larger community only by signaling -- by explaining ourselves."
For the science community this signaling is more than just biochemical, it means reaching across disciplines. It will take biologists, ecologists, physical scientists, computer scientists, engineers, and surely those in the behavioral sciences to understand the signals for survivability.
The new challenges of understanding biocomplexity will draw us together across diverse disciplines. As we collaborate in an array of disciplines, our work will connect and overlap. It will gain strength and insight from that blending.
This means that as scientists we must get better at signaling to each other. Only by doing this can we develop a universal language that allows all of us to communicate and develop an understanding of the biocomplexity that defines life on this planet.
As scientists, we must also become more comfortable with dialogue -- that's our signaling -- to the larger public about the value and contributions of science to society. That signaling requires astute listening as well.
As biologists and ecologists, we are especially aware that each species and organism has distinct characteristics and capabilities. So too with our human species. Perhaps our most distinct capability is to be able to plan and construct a sustainable future for the benefit of all species and ecosystems.
Despite this capability, just learning to decipher the delicate interactions and balances of a complex ecosystem like Chesapeake Bay is a significant challenge -- at least as difficult as learning how to understand, influence, and educate our own species. Survival, let alone the capability to flourish, depends on our ability to achieve what is a truly interdisciplinary task.
We should aspire to move from remediation to increasingly predictive and more powerfully preventive capabilities. The challenge is, at the same time, to be more focused, yet more integrated in our research. No problems exist in isolation, whether they are scientific, social, or technical. More often, they are all three at once.
My own research on the ancient scourge, cholera, which is still very much with us today, can provide an example. It is now possible to utilize remote sensing and computer processing to integrate ecological, epidemiological, and remotely sensed spatial data to produce predictive models of cholera outbreaks.
We can now predict conditions conducive to pandemics of cholera in those parts of the world where the public health infrastructure is inadequate or even lacking. Populations can then be instructed on preventive public health measures. This is a major step forward from the old pattern of remedial action, that is, reacting to major, devastating epidemics.
In the long run, our individual research knowledge and understanding will not be sufficient for the larger scale research programs. Our cooperative attitude -- and our comprehensive vision -- will also be needed to devise and implement strategies at the interdisciplinary level.
This sets a goal for all of us. Our new knowledge, and our approach to solving problems must be collaborative. This will move us toward sustaining all living systems, ourselves included. We already have considerable evidence to suggest that the human species often works in opposition to its own long-term best interest.
The late-social philosopher, Lewis Mumford, wrote "Western society has accepted as unquestionable a technological imperative that is quite ...arbitrary ...Not merely the duty ...to create technological novelties, but equally the duty to surrender to these novelties unconditionally ...without respect to their human consequences."
Mumford does not devalue science and technology here. Instead he is critical of our lack of attention historically to our values and our vision as a society. He was telling us something worthy of our serious consideration. His words should make us attentive not only to what we are able to do but to ask ourselves if those things we can do take us to where we need to go as a society and a civilization.
Marshall McLuhan said more simplistically, "First we shape our tools and then our tools shape us."
Today, we have sophisticated research methods and tools, thanks to the work and the creativity of many of you here. This capability, and our growing awareness of the effect of human exploration and settlement on the planet, will drive our new agenda for the 21st century.
The Chinese have an oft-quoted expression that is both cautionary and opportunistic: "May you live in interesting times." We surely are living in those times. The expanding knowledge of our research base holds the key. It will both caution us of the dangers and allow us to take advantage of the opportunities for positive change.
As I said earlier, we in the life sciences have been aware of the issues and problems of the Earth's biosphere for decades now. But it is not enough for us to just be aware of the problems. We need to play an active part in the solutions.
The solutions are not only scientific, but social and political. They will require your active participation. In the end, our task for science in the 21st century will be to acknowledge that Coleridge was a good poet but not a good prophet in his devastating scenario. I am convinced we will meet the challenge.
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The Covid Collection
Coping with Quarantine
3D Collection
(Re)Constructing Reality
Documenting the Period
Covid Stories
The Creation Process
"Nostalgia is a necessary thing, I believe, and a way for all of us to find peace in that which we have accomplished, or even failed to accomplish."
R.A. Salvatore (1989)
The term 'nostalgia' was introduced by Johannes Hofer (1688) in his medical dissertation to refer to a fatal disease: "homesickness." In our modern society, nostalgia has another meaning pertaining more to personal emotions. Baker and Kennedy (1994) define nostalgia as "a sentimental or bittersweet yearning for an experience, product, or service from the past" (p. 170). In other words, when one feels nostalgic, they experience not only sadness for what no longer is, but also happiness and comfort associated with the memories of the past.
Many elements of everyday life can become nostalgic experiences, including interactions with family, friends, particular objects, special events, and treasured places. For example, the smell of home-made cuisine may evoke the person's nostalgic memory of families and home country. Mostly, people who feel nostalgic are eager to revert to the good times of the past. As nostalgic experience allows people to maintain their identity, it can relieve certain negative feelings like anxiety and depression (David, 1979). During the COVID-19 pandemic, engaging with nostalgic feelings helps some people cope with the experiences of being separated from family and friends, fear and uncertainty for the future.
In this theme of the COVID-19 Collection, we connect personal objects of our peers to their nostalgic memories, to present a unique reality of the COVID-19 pandemic. We categorize the theme into three types of nostalgic experiences: Culinary nostalgia, Nostalgic media, and Cultural nostalgia. Through these subthemes, we explore how people show their desires to go back to pre-COVID days, and how they find the comfort zones inside their nostalgic experiences.
Where our Objects Come from
Culinary Nostalgia: Comfort Food and Belonging
"When people turn to food and they're not physically hungry, it means that they're using food for something else besides satisfying the needs of the body. They're using it for a different kind of hunger—an emotional hunger, a psychological hunger, or a spiritual hunger."
Geneen Roth (Hughes & Hughes, 2007)
Many people experienced isolation, stress, separation, loneliness, and repetitive daily monotony during the COVID-19 pandemic. This has had visible impacts on their routines in daily life, including in their practices surrounding food. Sometimes explorative, sometimes sentimental, for many the role that food has played in bringing them comfort and more than one kind of nourishment whilst isolated within their kitchens has been formative in shaping their experiences of the pandemic.
Some comforting dishes prepared by author Rhys Shurey and loved ones during quarantine.
Food becomes nostalgic through the recipes we store, remember, pass on, and repeatedly recreate. According to Baker et al. (2005), culinary recipes; from an extravagant 5-course dinner to a simple loaf of banana bread, play a symbolic role in collective and cultural rituals, strengthening family ties, reminding us of our past, childhood and upbringing, and helping to construct our identities. Food practices are avenues through which nostalgia can be lived out by individuals, shared between groups, cultures and families, and passed onto future generations.
Pressed by the anxieties of COVID times, people have found shelter from the storm through preparing familiar food: dusting off old recipe books, grinding spices in their mortar and pestles, and in many ways returning to the flavors and aromas of childhood which bring them comfort and a sense of belonging.
This desire to return to nostalgic 'comfort foods' in times of stress and worry is a well-known cultural trope. Psychological researchers Troisi et al. (2011) suggest that part of the 'comfort' of comfort food lies in how its consumption is cognitively associated with personal relationships. They argue that, particularly in times of loneliness or when a person's sense of belonging is in jeopardy, the consumption of comfort food can actually act as a surrogate for social interaction, particularly in times which a sense of belonging is sought. This reflects clearly the experiences of many who have been separated from their families, friends and loved ones during the pandemic and sought food as an avenue of reassurance. The foods we consume for comfort therefore can be seen to nourish us in many meaningful and multifaceted ways.
Nostalgic Media: Revisiting Past Favorites
"Across TV and Music, more than half of consumers are seeking comfort in familiar, nostalgic content."
"COVID-19 tracking" (2021, p. 9)
Soon after quarantines and lockdowns around the world went into effect, often occupied by nothing but their own homes, many people turned to entertainment as a way to pass the time. However, they did not just turn to any source of entertainment. Overwhelmingly, people sought out pieces of media they had previously enjoyed, often during childhood. One ongoing study during the pandemic (cited in Ulaby, 2020) by Billboard and Nielsen Music (an MRC Data service), concluded in their first release that: "More than half of consumers today seek comfort in familiar music and television shows. 87 percent of respondents reported listening to the same music they normally listen to, and 54 percent said they'd recently rewatched episodes of an old favorite TV show" (para. 3).
The pandemic brought forth lots of worries and uncertainties. Things that we took for granted, such as our ability to move around freely, see friends, but also our health, were suddenly no longer guaranteed. Nostalgic forms of media – whether they be books, TV-shows, or films – provided a way for people to experience the comfort of past (pre-COVID) experiences.
A news segment about the role of nostalgia during quarantine
Additionally, rewatching or rereading things that one has previously consumed is a 'safe' experience, because it provides no uncertainties, an important factor considering the current state of the world. As one interviewee in Ulaby (2020) puts it: "I'll start to watch something I thought I wanted to watch, but then I just stop after a couple of minutes … It seems like a lot of effort to start a new thing, if that makes sense" (para 4).
Across the world people turned to the favorites of their youth for comfort and relaxation, escaping the uncertainties of real-world events. From rereading Harry Potter to rewatching Avatar the Last Airbender, everyone had their own trips down memory lane to ease the experience of being stuck, lonely and bored at home.
Cultural Nostalgia: Attachment to the Past
"Nostalgia comes from the Greek words nosto, meaning "returning home," and algia, meaning "pain" or "suffering." Hence, nostalgia literally means "homesickness.""
Smeekes, A. & Jetten, J (2016)
Since the outbreak of the COVID-19 pandemic, the closure of various places as well as restrictive travel regulations has prevented many people from going to other places, for some even going home. For those outside their home country, the longing for their home and the feeling of nostalgia for their culture can easily be triggered by some objects which carry unique cultural meanings as well as memories. In this way, even a commodity souvenir can bring up the feeling of cultural nostalgia and homesickness for those who cannot go home because of the pandemic.
Notepaper Brick from The Palace Museum by covid19digitalcollection on Sketchfab
According to psychological studies, nostalgia is typically defined as a longing for the past resulting from separation in time, while homesickness is understood as the longing for home that results from the separation from home in space (Wildschut et al, 2006). Further, nostalgia is considered to result in predominantly positive consequences for individual well-being whereas homesickness is associated with psychological discomfort and distress (Sedikides et al, 2009). However, Smeekes & Jetten (2016) suggest that aside from emotions experienced as an individual, people may also feel collective emotions related to the groups they belong to (p.131).
It is perhaps unsurprising that even commodity objects such as souvenirs can stir up the collective emotions of the individuals who are separated from their homeland during the COVID-19 pandemic. Through engaging with the objects which stimulate cultural values and nostalgic memories, such as drinking traditional South American mate drink with a souvenir mate cup or using a museum-bought notepaper brick depicting a traditional Chinese painting, people can feel more attached with their own home and country. Therefore, by engaging with culturally nostalgic objects and bringing the self closer to their cultural collective, people can also begin to feel a little less separated, a little less isolated, from those they miss elsewhere in the world.
Objects Associated with this Theme
Explore the narratives hidden behind each object and gain a deeper understanding of how they can act as coping mechanisms.
Meditation Pillow
By Marc Boas
By Lisa Klöcker
Notepaper Brick from The Palace Museum
By Jingwen Chen
Granite Mortar and Pestle
By Rhys Shurey
"Harry Potter and the Philosopher's Stone" Book
By Céline Lanneau
The Peruvian Mate Cup
By Lucia del Pilar Chirinos Franco
Baker S. M. and Kennedy P. F. (1994). Death By Nostalgia: a Diagnosis of Context-Specific Cases. NA – Advances in Consumer Research Volume 21, eds. Chris T. Allen and Deborah Roedder John, Provo, UT : Association for Consumer Research, 169-174.
COVID-19 tracking the impact on the Entertainment Landscape: Release 1. (2020, April 13). Billboard. Retrieved February 26, 2021, from https://www.billboard.com/articles/insight-reports/9355929/covid-19-tracking-the-impact-on-the-entertainment-landscape-release-1?utm_content=pass.
Hughes, J., Hughes, D. (2007). Food, emotions, and the search for true nourishment: Unraveling our complex relationship with food: An interview with Geneen Roth. Share Guide. Retrieved from http://www.shareguide.com/RothGeneen.html
Neve, T. (2017, December 7). The History and Uses of the Mortar and Pestle. Cambridge Environmental Products, Inc. https://cambridgeenviro.com/blogs/news/the-history-and-uses-of-the-mortar-and-pestle#:~:text=Mortar%20and%20Pestles%20were%20described,for%20the%20grinding%20of%20spices.
Rowling, J.K. (2006). Biography. JKRowling.com. https://web.archive.org/web/20060421032312/http://www.jkrowling.com/textonly/en/biography.cfm
Sedikides, C., Wildschut, T., Routledge, C., Arndt, J., & Zhou, X. (2009). Buffering acculturative stress and facilitating cultural adaptation: Nostalgia as a psychological resource.
Smeekes, A., & Jetten, J. (2016). Longing for one's home country: National nostalgia and acculturation among immigrants and natives. Utrecht, The Netherlands: Utrecht University, Ercomer.
Troisi, J. D., & Gabriel, S. (2011). Chicken Soup Really Is Good for the Soul: "Comfort Food" Fulfills the Need to Belong. Psychological Science, 22(6), 747–753. https://doi.org/10.1177/0956797611407931
Ulaby, N. (2020, April 15). Returning To Old Favorites? Comfort TV (And Books, And Music) Is A New Trend. NPR. https://www.npr.org/sections/coronavirus-live-updates/2020/04/15/834299376/returning-to-old-favorites-comfort-tv-and-books-and-music-is-a-new-trend. Wildschut, T., Sedikides, C., Arndt, J., & Routledge, C. (2006). Nostalgia: content, triggers, functions. Journal of personality and social psychology, 91(5), 975.
MA Media Studies: Digital Cultures
Class 2020-2021
Copyright © 2023 FASoS, Maastricht University The Covid Collection | Zubin Pro by Catch Themes


* The thing that makes Macho's dad smile the most is his personality and how funny and hyper he is.
* His most endearing habit is dragging the blankets off the couch when someone is sitting there with one.
* If Macho had a career he would be a professional swimmer.
* Macho's favorite thing to do with his dad is go on walks.
* His favorite place to hang out is on the couch.
Macho is from out of town and has been coming to us off and on for a few years. In the fall of 2018 he came to see us because he was limping, and holding his leg weirdly when he was sitting. We thought it was something wrong with his hips. We put him on a joint supplement and gave him an injection and tried a few different things over a couple weeks, but nothing seemed to be helping him. We later found out that his minor ACL tear turned into a major ACL tear. His dad then decided to do surgery to repair his ACL. After a couple re-checks and time to heal, Macho is doing great. He has been such a trooper through all this, and every time he comes to the clinic he is excited and wagging his tail. We are so happy that we were able to help him live a pain free life again.


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Kidney Function Decline May Not Be Good Indicator of Trial Outcomes in Alport Syndrome Patients, Study Suggests
by Magdalena Kegel | August 18, 2017
The rate at which patients with Alport syndrome lose their kidney function varies widely between patients and even within the same individual, according to a study in the Canadian Journal of Kidney Health and Disease.
This insight is crucial when studying potential interventions in clinical trials, which tend to observe patients for a short time only, researchers at the University of British Columbia in Canada said. By not taking this variability into account, trial researchers risk erring in their conclusions, the study said.
That study, called, "The Variability of Estimated Glomerular Filtration Rate Decline in Alport Syndrome," followed a group of 37 patients with Alport syndrome for two years to determine if their disease was progressing, stable, or improving.
To assess the decline in kidney function, researchers repeatedly measured patients' estimated glomerular filtration rate (eGFR) during the study period. This rate tracks kidney function by measuring the blood that passes through kidney filters called glomeruli.
The patients were listed in a kidney disease clinical information system called PROMIS. The majority (78%) of those studied were men, with a median age of 36.
Analyses showed that the number of patients whose disease was progressing differed depending on the eGFR at the start of the study. A high number of patients whose disease was progressing was seen among those with high kidney function at the beginning of the study, while those with lower eGFR values were stable to a larger extent.
Among those having an eGFR of 45-60 mL/min/1.73 m2, 73.7% were progressing, while 23.6% were stable. In the group with intermediate function and an eGFR of 30-45 mL/min/1.73 m2, 45.6% were progressing and 53.4% were stable. Of those with an eGFR in the lowest range, at 15-30 mL/min/1.73 m2, only 25.7% were progressing, while 54.8% were stable and 19.5% regressed.
The data showed that while some patients had kidney function that declined in a linear fashion, others had an increasingly rapid disease course. Still others had alternating periods of rapid and slow decline over the two-year period; although they had declined, improvement was seen at a later date.
This variability also was seen among members of the same family, which suggests that a specific mutation provides little information about how the disease will progress in an individual.
The findings suggest that clinical trials might need to rely on other markers of disease progression to determine an intervention's effectiveness.
Magdalena Kegel Magdalena holds an MSc in Pharmaceutical Bioscience and an interdisciplinary PhD merging the fields of psychiatry, immunology and neuropharmacology. Her previous research focused on metabolic and immunologic changes in psychotic disorders. She is now focusing on science writing, allowing her to culture her passion for medical science and human health.
clinical trials, disease progression, eGFR, estimated glomerular filtration rate, Kidney function


Who Hires Portillo & Associates Real Estate?
Why? Because their businesses are "Teams", so they understand and appreciate Dan Portillo's Team System. Those people are accustomed to bringing people who play different, specialized roles together as a team, and know that to be the most productive approach to complex situations – rather than having one person trying to juggle all the balls, wear all the hats. They know from their own experience that no one person can be good at everything.
Why? They quickly recognize the superiority of Dan Portillo's sophisticated System for selling homes as quickly as possible, for top dollar. They have the background and experience to understand the power of the multi-media, multi-step System that Dan has perfected. They understand that other real estate agents from all over the area respect Dan's marketing System. They see, quite simply, that the realtors using Dan Portillo's System do more things simultaneously to get homes sold fast and for top dollar.
Why? Because the Dan Portillo System features methods of marketing and selling their homes that minimizes their involvement and inconvenience. For example, the Dan Portillo Tour of Homes (in place of ordinary open houses) reduces the amount of time their home is "open to the public." The Dan Portillo pre-selection and qualifying process reduces the number of people who troop in and out of the home with no real interest in it or ability to buy it immediately.
Why? Dan tends to attract the client who wants it done right the first time. That's because Dan sells a much higher percentage of homes listed compared to the average agents in the area. If you hire the wrong agent, after weeks or even months go by without your home being sold, you have to get rid of that agent and start all over again. Many sellers go through three agents before getting their home finally sold – and by then they tend to compromise their price severely. The homeowner who is determined to get it right the first time compares Dan's track record to others and makes the obvious choice.


Welcome to Enclave Vision Associates!
Enclave Vision Associates is proud to serve West Houston and the Energy Corridor with exceptional patient service and a friendly staff.
Drs. Hengst and Montgomery utilize the latest technology to evaluate the health of your eyes, and take great pride in offering every patient the absolute best in eye care – whether that is prescribing eyeglasses or contact lenses, diagnosing eye conditions such as cataracts and glaucoma, or co-managing LASIK and other medical eye procedures.
With our state-of-the-art facility and on-call care for eye emergencies, we are there when you need us the most. We look forward to assisting you in all of your family's eye care and eye health needs.