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Kerbala University
karbala journal of pharmaceutical sciences
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karbala journal of pharmaceutical sciences, Volume 8, Issue 13, Pages 0-0
Anti-angiogenic Activity of Cuminum cyminum seeds extract: in vivo study
Ahmed M Mahmood; Hayder B Sahib
The objective of this study is to identify the possible anti – angiogenic activity of Cuminum cyminum seeds extract in vivo assays. Cuminum cyminum seeds powder was extracted by methanol using the cold method "maceration" as extraction process. The in vivo study was done by Chick Chlrioallontoic Membrane assay (CAM assay).Then phytochemical analysis done by Gas Chromatography mass spectroscopy (GC). The obtained data revealed that methanolic extract of Cuminum cyminum seeds significantly inhibit blood vessels growth when it compared to negative control and the inhibition zone about (++). And according to GC mass the extract showed chemicals related poly phenol group like tannins and flavonoids that may be responsible on anti angiogenic activity of Cuminum cyminum seeds.
The antihyperglycemic and antihyperlipidemic effect of ethanolic extract of Apium Graveolens (celery) in Streptozocin/ high fat diet induced hyperglycemic mice.
Alaa H. Abbas; Abdulkareem H. Abd; Shihab AbdulRhman; Ibrahim S. Abbas
karbala journal of pharmaceutical sciences, Volume 8, Issue 13, Pages 10-28
In spite of the drugs available for the treatment of diabetes and high blood lipids but still accompanied by undesirable side effects, and so a wide attention and tendency for herbal and poly herbal treatment because of the lack of side effects, and low cost and accessibility.
Celery seeds, also known scientifically as Apium graveolens belong to the plant family Apiaceae . Analysis of the active ingredients of the ethanol extract of celery seeds proved the presence of different compounds, including terpenes and fatty acids, but fatty acids were the largest proportion of the rest of the substances that were examined through GC-MS.
The aim of the current study is to verify the effectiveness of ethanolic extract of A. graveolens in reducing hyperglycemia and high lipids in hyperglycemic mice .
Fourty male mice were used in the current study and mice were divided into 4 equel groups. . Group-1 (control) received distilled water (50µl ) orally and standard diet. Group-2 (drug control) orally and injected with STZ (150 mg/Kg) intraperitonially and received distilled water (50µl per day) orally with HFD . Group-3 injected with STZ and received glyburide (p.o) 0.5 mg/kg per day as standard drug with HFD for 28 days . Group-4 injected with STZ and received ethanolic extract of celery seed (400 mg/kg) per day by gastric lavage as well as HFD.
After the treatment was completed, blood samples were collected for analysis and isolation of liver and pancreas tissue for the histological examination.
The ethanolic extract of A. graveolens showed a significant decreasing in the level of blood glucose, lipid profile , serum (C-peptide) , improved (GSH), and reduction in level of MDA when compared with untreated group. The presence of variety of active consistuents in A. graveolens like flavonoids , turbines and unsaturated fatty acids may be the reason for the antihyperglycemic and antihyperlipidemic effects.
Comparison Between Two Extraction Methods on Total Extract with Primary Investigation of Phytochemical Compounds of Some Medicinal Plants used in Treatment of Urinary Tract Disease.
Abbas Moussa Kashmar; Estabraq H. Naser
Phytochemical investigation and urinary tract infection (UTI) treatment of parsley seeds, fennel seeds, and corn silk were studied. The aim of this study was conducted to investigation the best method of extraction on total extract, with preliminary screening of phytochemical compounds of parsley seeds (Petroselinum sativum), fennel seeds ( Foeniculum vulgare Mill.) and corn silk ( Zea mays L.) to treat urinary tract diseases. The parts of each plant were extracted by two different methods, hot method by using distilled water and cold method was done by maceration with 90% ethanol at room temperature. In both methods the extract was dried under reduced pressure by rotary evaporator. Preliminary investigation of phytochemical compounds was done by using alkaline reagent test for flavonoids, foam test for saponins, terpenoids test for terpenoids, fehling's reagent for reducing sugar and Dragendroff's reagent for alkaloids. The qualitative identification was done by TLC. The results showed that the percentage yields of crud extracts by boiling with distilled water were higher than that obtained from cold maceration with 90% ethanol. The percentage of phytochemical components, flavonoids, saponins, reducing sugar, terpenoids and alkaloids of water extracts were higher than that in ethanolic extracts.
The effect of extracts in the treatment of UTI displayed that the combination of three plants water extracts were stronger than ethanolic extract. Based on our knowledge this is the first study on the effect of extracts from P. sativum, F. vulgare, and Z. mays in the treatment of UTI.
Serum level of cytokine (interleukin-10 ( IL-10 )) and oxidative stress markers Malondiaaldehyde and super oxide dismutase(MDA and SOD) in Iraqi patients with thyroid cancer
Israa A.Abdul Kareem
Thyroid cancer is the most common endocrine malignancy and its incidence continues to rise yearly .Thyroid carcinoma, in most cases, presents clinically as a solitary nodule or as a dominant nodule within a multinodular thyroid gland. it is very important to identify one or more markers to distinguish thyroid cancer from different types of thyroid disease., Oxidative stress is considered to be involved in the pathophysiology of all cancers.Interleukin-10 is a pleiotropic cytokine with both anti-inflammatory and anti-angiogenic properties that may be involved in the pathogenesis of autoimmune thyroid diseases. Thyroid cancer cells of all histological variants produce considerable amounts of IL-10, which might be important in the pathological features of thyroid cancer and/or outcome. Our study aimed to evaluate IL-10 and oxidative stress markers, Malondiaaldehyde and super oxide dismutase (MDA&SOD) levels in sera of patients with CA thyroid and their close relatives compared to healthy control.and to study the correlation of these markers before and after the thyroidectomy operation compared with 1st to 2nd relatives and healthy controls. This 89study includes Thirty (30) subjects as the study sample is made of: 1) 15 diagnosed cases of CA thyroid before surgery and post-surgical treatment, 2) 15 cases of their 1st, or 2nd degree relatives; and 30 healthy subjects (control) would be recruited from surgical clinic in Al-Imamain Al- kadhimain city hospital from October 2014 up to December of 2016.Serum IL-10 was estimated using an Enzyme-Linked Immunosorbant Assay ( ELISA ) technique. Serum MDA levels were assessed using thiobarbituric acid (TBA) method of Buege and Aust , while SOD was measured by Burtis and Ashwood, using modified photochemical Nitroblue Tetrazolium (NBT) method utilizing sodium cyanide as peroxidase inhibitor.Analysis of serum levels demonstrated significantly increased levels of IL-10 in cancer patients between pre-thyroidectomy and post-thyroidectomy(p<0.01) and significantly increased compared with control groups (p<0.001) , SOD activities of pre-thyroidectomy, post-thyroidectomy and control groups were not different (p>0.05).In post- thyroidectomy MDA levels decreased compared to prethyroidectomy levels( p<0.01).also thyroid cancer significantly decreased compared with control groups (p<0.001). Although post-thyroidectomy MDA levels significantly decreased, but still higher than the healthy control group.its concluded that cytokine profile (IL-10) is reflective of an inflammatory immune response. These cytokines may increase the pathogenicity of thyroid CA and may be useful as biomarkers or targets for therapy. SOD does not seem to change with thyroid cancer and thyroidectomy but MDA change.IL-10 & MDA may be a more useful for monitoring the clinical status of thyroid cancer patients.
l Comparative bioavailability (bioequivalence) of a newly developed formula of Clopidogrel against Actavis tablets in fasting healthy male adult Iraqi subjects
Mowafaq M. Ghareeb
Objective: The study was performed to compare the bioavailability (bioequivalence) of a newly developed generic formula of clopidogrel 75 mg tablet as a test product against Actavis tablet containing 75 mg clopidogrel as the reference formula.
Methods: The newly developed generic formula of clopidogrel tablet was prepared using co-processed excipients composed mainly of microcrystalline cellulose, superdisintegrant, glidant, and magnesium stearate. In vitro dissolution test was done first to compare the test to the reference formulas, followed by the in vivo study. Both drug products were administered to 40 Iraqi male healthy adult subjects under fasting state applying randomized, two periods, two sequences, two-way crossover design with one week washout period between dosing. Blood samples were obtained over 72 hours interval from each subject, and the concentrations of the inactive metabolite of clopidogrel (clopidogrel carboxylic acid) were determined in serum by LC-MS/MS method. From serum concentration versus time data of each subject, the pharmacokinetics parameters AUC0-t, AUC0-infinity, Cmax, Tmax, and T0.5 were calculated applying non-compartmental data analysis.
Results: The dissolution profile of the test product was found to be similar to the reference product with similarity factor (f2) equal to 79.4%. The geometric mean ratios of the primary pharmacokinetic parameters used for bioequivalence testing of the test/reference products were; 102.47% for AUC0-t, 102.68% for AUC0-infinity and 101.85% for Cmax. The 90% confidence intervals for AUC0-t, AUC0-infinity and Cmax were 93.46-109.18 %, 98.78-108.32% and 91.65-104.33%, respectively. Since the 90% confidence intervals for these parameters were within the 80–125% interval proposed by FDA, it was concluded that the newly developed clopidogrel 75 mg tablet was bioequivalent to the reference product produced by Actavis in term of both the rate and extent of absorption and bioavailability. Consequently, the newly developed clopidogrel 75 mg tablet is interchangeable with clopidogrel 75 mg tablet manufactured by Actavis and can be prescribed as an alternative in the Iraqi market.
Anti-inflammatory effect of turmeric plant ( Curcuma longa L. ) rhizomes and myrrh (Commiphora myrrha L.) gums and ginkgo Ginkgo biloba L. leaves ( tablets ) extracts
Ahmed Abies Motar; Rajaa Ali Hussein; Meison Abdulbary
Back ground: the plants importance resulting from their uses as a nutrition source and for their therapeutic effect. These plants include turmeric , myrrh and ginkgo.
Aim of study: this study was conducted to test the anti-inflammatory effectiveness of turmeric plant ( Curcuma longa L. ) rhizomes and myrrh (Commiphora myrrha L.) gums and ginkgo , Ginkgo biloba L. leaves ( tablets )extracts.
Method: plants under study were extracted by soxhlet using methanol as a solvent, and then was fractioned by water, chloroform, ethyl acetate and hexane. The extracts tested to determine the anti-inflammatory effect through testing their ability to maintain the stability of the membranes of red blood cells , prevent protein denaturation and heat induced hemolysis.
Results: the result showed the effectiveness of all the plants under study in resisting inflammation with compared to standard medicines (Aspirin 100μg / ml and Diclofenac sodium 100μg / ml).
Conclusion: It can be concluded that the presence of secondary metabolites as alkaloid, polyphenolic compounds and phenolic acid in the plants under study would be marked a good anti-inflammatory effect.
Effect of Hyper- and Hypothyroidism on many physiological parameters and the rate of some diseases
Luma Qasim Ali; Ali Ibrahim Alsamawi; Jamela Jouda
Thyroid diseases are the second most public endocrine system disorder which effect many systems of the body. This work aimed to study the effect of hyper- and hypothyroidism on the blood pressure (systolic and diastolic, hemoglobin level (Hb), fasting blood sugar level (FBS), and decayed, missing, and fulling teeth (dmf-t) and study the frequencies of anemia, hypertension and diabetes in these three groups. This study included forty patients, who were previously diagnosed with hyperthyroidism (20case) and hypothyroidism (20case) as well as 10 healthy as control (male and female) in age group of 30-65 years. There were significant differences in HB levels among the three groups were detected. The lowest was in hypothyroidism and the highest was in control. The frequency of anemia was significantly higher in the hyper- and hypothyroidism compared to control. The systolic blood pressure was significantly higher in the hyperthyroidism group. Conversely, significantly higher diastolic blood pressure in the hypothyroidism group was detected. The frequencies of Hypertension were significantly higher in the hyperthyroidism and hypothyroidism compared to control. There also were significantly differences in the FBS levels among the three groups. The frequency of diabetic was significantly higher in the hyper- and hypothyroidism compared to control. According to obtained data we suggested that all patients with hypothyroidism and hyperthyroidism should be periodically evaluated for probably hematological, cardiovascular, biochemical, and oral changes.
The employment of MALDI-ToF in the chemical analysis of fingermarks.
Zaid Al-Obaidi; Simona Francese
karbala journal of pharmaceutical sciences, Volume 8, Issue 13, Pages 79-105
Background and objectives: Many endogenous and exogenous molecules with different chemical nature including lipids, vitamins, amino acids polymers and other small molecules have been detected by Matrix¬assisted laser desorption/ionization (MALDI). Many studies were done to detect proteins in body fluids; however, few focused on detecting proteins in sweat. Recently peptides and small proteins in finger marks were detected in laboratory experiments including dermcidin and dermcidin-derived peptides. The aim of this study is to confirm the identity of dermcidin and other peptide species that can be found within fingermarks.
Methodology: This study was performed with the employment of MALDI following two constitutive enzymatic digestions by trypsin and carboxypeptidase respectively. Bioinformatics tools were employed to identify and verify peptide maps. This work is important to both forensic and biomedical science fields. These sciences are interested in dermcidin and dermcidin-derived peptides. Also this study established the protocols with a high potential for many other detectable peptides.
Results: In this work, the detection and identification of dermcidin and dermcidin-derived molecules and possibly dual specificity phosphatase (DUSP27_ HUMAN, formerly known as DUPD1) has been achieved. This has been done by using enzymatic digestions while the expected fragments obtained with MALDI and confirmed by the employment of bioinformatics tools.
Discussion and Conclusions: The species of dermcidin and dermcidin tryptic digested peptides have been successfully identified directly in fingermark. Extra efforts are recommended to identify and confirm other peptides detected in fingermarks.
Correlation between Endogenous Vitamin D Status and Body Mass Index in Asthmatic Patients Receiving Adjuvant Vitamin D3 Supplement
RASHA SAADI ABBAS; MANAL KHALID ABDULRIDHA; MOSTAFA ABDALFATAH SHAFEK; HADEEL DELMAN NAJIM
karbala journal of pharmaceutical sciences, Volume 8, Issue 13, Pages 106-121
Background: Most studies showed that the incidence of asthma is frequently associated with increased body mass index (BMI), vitamin D deficiency has been proposed as a risk factor that could explain a significant proportion of increased pattern of asthma prevalence. This study was aimed to track a correlation between body mass index and vitamin D status effect on asthma control in asthmatic patients.
Patients and Methods: This is a prospective randomized -controlled open-label interventional study to evaluate effect of vitamin D3 on asthma control and it's correlation with body mass index in asthmatic patients who are allocated into two main groups: Group 1: Include 20 patients who have diagnosed with asthma are assigned to receive conventional therapy for asthma according to disease stage and severity for three months period. Group 2: Include 24 patients who have diagnosed with asthma are assigned to receive conventional therapy for asthma according to disease stage and severity plus 2000 I.U vitamin D3 fast dissolve mini tablet (Natrol, USA) for three months period. Serum 25-OH vitamin D level, Body mass index (BMI), asthma control test (ACT) scoring system was measured both initially and after three months treatment.
Results: A highly significant improvement in asthma control found in patients after 3 months treatment with vitamin D3 supplement compared to pre treatment level (P<0.01), and was found significantly that among the 10 (42%) obese patients in group 2 with vitamin D deficiency, 6(25%) patients gained vitamin D insufficiency and 2(8%) patients gained vitamin D sufficiency after supplementation with vitamin D3 (P<0.01). After treatment body mass index inversely correlated with vitamin D level in patients receive conventional therapy, meanwhile in patients with vitamin D3 supplement the change in the body mass index after vitamin D3 treatment was parallel to the improvement in endogenous vitamin D level. Also the reduction in the body mass index after vitamin D3 treatment produce a positive correlation with asthma control test, though no significant (P>0.05). No direct correlation was found between endogenous vitamin D level and asthma control test in both study groups.
Conclusion: After vitamin D3 supplement in the current study, the change in the body mass index produce improvement in endogenous vitamin D status parallel to the change in the body mass index and markedly improvement in asthma control. Also the reduction in the body mass index after vitamin D3 treatment was positively correlated with asthma control.
The protective effect of Trigonella foenum- graecum L. seeds extract in high fat diet-streptozotocin induced hyperglycemic mice
Marwa A. Al-Dabbagh; Abdulkareem H. Abd; Noor M. Nasser; Ibrahim S.Abbas
Diabetes mellitus is a chronic metabolic disorder which affects carbohydrate, protein, and fat metabolism. associated with high morbidity and mortality. characterized by hyperglycemia together with biochemical alterations of glucose and lipid metabolism. Hyperglycemia and hyperlipidemia result in development of oxidative stress, systemic and local inflammation which were an critical factors for degradation of β-cells, insulin resistance and type II diabetes .Herbal medicine is one of the therapeutic strategies in the management of diabetes mellitus. It is considered to be less toxic and have fewer side effects than synthetic ones .The objective of this study was to investigate the possible protective effect of Trigonella foenum- graecum L. seeds(TFG) extract in High Fat Diet ∕ Streptozotocin -induced toxicity in mice. The seeds of TFG were defatted by soxhelt apparatus with n-hexane ,then marc was macerated with ethanol to obtain total ethanol extract. Thirty two male albino mice were fed high fat diet for two week plus single dose of streptozotocin 120mg ∕kg intraperitoneally to generate typeII diabetes model with increased adiposity. The protective and hypoglycemic activity of seeds extract against toxicity and hyperglycemia induced was evaluated in mice. Glimepiride was used as a standard treatment .FBG, serum C-peptide ,TC , Triglycerides ,HDL, LDL levels were measured at the end of 28th day of experiment then the animal sacrificed and liver and pancreas sections were prepared and stained for histological evaluation. This study was resulted in that (TFG) seed extract cause; FBG, serum lipid profile in hyperglycemic mice significantly decrease, It also increase serum C-peptide ,Glutathione and decrease Malondialdehyde levels significantly compared to untreated group; this was associated with improving histological features that impaired during STZ exposure. In conclusion, Defatted seeds extract has potential anti-hyperglycemic and hepatoprotective effect with free radical scavenging ability against STZ-induced toxicity.
The In Vitro Release Study Of Ceftazidime drug From Synthesized Strontium Flourapatite And Strontium Hydroxyapatite Coated Particles.
Erfan A. S. Alassadi; Zaki N. Kadhim; Mazin N. Mousa
Two compounds, strontium flourapatite (SrFA) and strontium hydroxyapatite (SrHA), were synthesized using wet chemical precipitation method. These compounds were characterized by Fourier transform infrared spectroscopy and X-ray diffraction techniques. The morphology and particle size for the resultant particles of the synthesized compounds were checked by scanning electron microscopy. The average particle size of strontium flourapatite was larger than that of strontium hydroxyapatite by 4.55 times. The particles of each compound were coated by trehalose sugar to decrease the possible ionic interactions with these synthesized compounds. An in vitro release study of ceftazidime antibiotic from the strontium flourapatite and strontium hydroxyapatite was performed in a simulated body fluid at a temperature of 37 oC. This release was studied by UV spectrophotometer at λmax of 258 nm for 12 hours. The results of the release study showed that the release of ceftazidime was faster from strontium flourapatite, but it was higher from strontium hydroxyapatite. The disparity in release rapidity and level was related to the considerable difference in the average particle size for the formed particles of the two synthesized compounds.
The indirect induction of human scabies to initiation autoimmune disease (SLE): Comprehensive study in marshes population of Thie-Qar
Alaa Abd-Alhasan Hamdan; Ali Jaleel Ali
Scabies is one of the disease that is considered an endemic and epidemic in Iraq, in this study it has been observed that other disease were found to be associated with scabies patients, and in order to investigate the mechanism by which the scabies may induce other disease (such as SLE) an immunological, hematological and immunobiochemical tests were investigated both in patients having scabies and scabies-SLE disease. High sensitive C-reactive protein was higher significant in all groups compared with control and higher significant in scabies-SLE as compare with scabies patients, IgG was higher significant in all groups as compare with control, lower significant in scabies-SLE as compare with scabies patients. IgM was higher significant in scabies patients as compare with control and lower significant in scabies-SLE. IgA was higher significant in all groups as compare with control. IgE was higher significant in all groups as compare with control, but lower significant in scabies-SLE as compare with scabies patients. C3 and C4 was lower significant in scabies-SLE as compare with both control and scabies patients. IL-6, IFN-γ, IL-18 and TNF-α was higher significant in all groups as compare with control also higher significant in scabies-SLE as compare with control. IL-1β was higher significant in all groups as compare with control, but not as compare scabies patients. IL-5 was higher significant in scabies as compare with control, but lower significant in scabies-SLE as compare with scabies. Eosinophil and neutrophil were higher significant in scabies as compare with control. Eosinophil, neutrophil, basophil and monocyte have lower significant in scabies-SLE as compare with control and scabies patients. superoxide dismutase (SOD) activity was higher significant in scabies patient only as compare with control, but lower significant in in scabies-SLE as compare with both control and scabies patients. Malondialdehyde (MAD) level was higher significant in scabies-SLE as compare with control. All data were considered significant at (P<0.05). The mechanisms of inflammation induced by mites may be related to the generation of excessive level of cytokines and antibodies against its proteins, so that triggering of excessive inflammatory responses, then developing autoimmune disease likes SLE.
The effect of olive oil on ibuprofen induced Renal toxicity in female rats.
Mohammed Talat Abbas; Rabab Murtadha Abed; Nazar Jabar Metab
Ibuprofen is an effective, cheap, and it is one of the most commonly non-steroidal anti-inflammatory drug, which are among the most frequent prescribed medications worldwide .The aim of this study is to investigate the protective effect of olive oil against ibuprofen-induced nephrotoxicity female albino rats. In this study we used 24 female white rats and divided them into 4 equal groups. Each experimental group consisted of six animals. group1, control they were fed on diet and water without any treatment, group2, ibuprofen given at dose 40 mg/kg/day orally by gastric tube for 30 days, group3,olive oil 2 ml/kg/day (oral administration) , group4, ibuprofen at dose of 40 mg/kg/day and olive oil 2 ml/kg/day (oral administration).Treatments were administered once daily for 30 days. After 30 days, biochemical and histopathological analysis were conducted to evaluate nephrotoxicity. Serum levels of urea, creatinine, calcium, glucose, phosphorus and amylase were measured. Animals treated with ibuprofen alone showed a significant increase in serum levels of urea, creatinine and glucose and significant decrease in calcium. Treatment of rats with olive oil showed significant improvement in kidney function, presumably as a result of decreased boichemical parameters associated with ibuprofen-induced nephrotoxicity. Histopathological examination of the rats kidney confirmed these observations. Therefore olive oil may protect against ibuprofen-induced nephrotoxicity.
The effect of olive oil (Olea europaea) on ibuprofen induced hepatotoxicity in female rats
Mohammed Talat Abbass; Rabab Murtadha Abed; Nazar Jabar Metab
Ibuprofen, a propionic acid derivative, is one of the most commonly Non-steroidal anti-inflammatory drugs, which are among the most frequently prescribed medications worldwide. The aim of this study is to investigate the protective effect of olive oil against ibuprofen-induced hepatotoxicity in female albino rats. In this study we used 24 female white rats and divided them into 4 equal groups. Each experimental group consisted of 6 animals. Group1,control they were fed on diet and water without any treatment ,group2, ibuprofen given at dose 40 mg/kg/day orally by gastric tube for 30 days, group3,olive oil 2 ml/kg/day (oral administation), group 4, ibuprofen at dose of 40 mg/kg/day and olive oil 2 ml/kg/day (oral administration).Treatments were administered once daily for 30 days. After 30 days, biochemical and histopathological analysis were conducted to evaluate hepatotoxicity. Serum levels of albumin, total proteins, and activity of AST, ALP, ALT and total bilirubin were measured. Animals treated with ibuprofen alone showed a significant increase in serum levels of ALT, AST and ALP and significant decrease in albumin and total proteins. Treatment of rats with olive oil showed significant improvement in hepatic function , presumably as a result of decreased boichemical parameters associated with ibuprofen-induced hepatotoxicity. Histopathological examination of the rats liver confirmed these observations. Therefore olive oil may protect against ibuprofen-induced hepatotoxicity.
CHARACTERIZATION OF INVASIVE DUCTAL CARCINOMA (IDC) IN PRE-AND POSTMENOPAUSAL WOMEN
KHALID MAHDI SALIH
Background: Previous findings reported that the majority of BC in Iraqi women is invasive ductal carcinoma (IDC) and the most frequent subtype is estrogen receptor (ER+) and/or progesterone receptor (PR+) expressed.
Objective: The present study is aimed to determine the association of age, BMI, and the levels of estradiol and progesterone hormones as well as their receptors in pre- and postmenopausal women with IDC that may ultimately help identify high-risk women who would benefit from increased screening or chemoprevention.
Methodology: Forty premenopausal and fifty eight (58) postmenopausal women with IDC, previously identified their ER and PR expression, are involved in this study. Age, BMI, and serum levels of estradiol and progesterone are determined.
Results: Both pre- and postmenopausal patients are presented at advanced age (45.8 ± 0.76, 59.1 ± 0.72 year) respectively. The average of BMI in both groups is within overweight category, but without significant difference between pre- and postmenopausal patients (27.3 ± 045, and 26.7±0.38 kg/m2 respectively). Both estradiol and progesterone serum levels are significantly higher in premenopausal patients (290.1± 6.5 pg/ml, and 2.55± 0.38 ng/ml respectively) than those in postmenopausal patients (264.1± pg/ml, and 0.75± ng/ml respectively). Just postmenopausal patients showed significant reverse association between E2 levels and the positively expression of ER (r= - 0.289), and PR (r= - 0.386), while progesterone levels showed significant association with age of pre- and postmenopausal, and with BMI of postmenopausal.
Conclusion: Collectively, age, estradiol level, and expression of ER and PR are the main factors associated with the diversity of breast cancer in pre- and postmenopausal women and ultimately they may help in identifying high-risk women who would benefit from increased screening or chemoprevention.
Synthesis, Characterization and Antimicrobial Study of Polycyclicacetal Derived From PVA and Its Complexes with (Cu+2, Ni+2, Zn+2 and Ag+1)
Maha A. Younus; Fadhel S.Matty; Sabreen A. Salah
Polymer metal complexes of poly vinyl alcohol acetal and Cu+2, Ni+2, Zn+2 and Ag+1 were synthesized from the reaction of PVA with 4-methoxybenzyldehyde. All compounds were characterized by FT-IR, UV-Visible, TGA, DTA, TG and Biological activity. The results showed that Polycyclicacetal behaved as bidentate through its oxygen atom of hydroxyl (O-H) groups of modified PVA. The tetrahedral geometrical was suggested for Cu+2, Zn+2 and Ag+1 complexes and octahedral geometrical Ni+2 complexes. The ligand and its metal complex showed good activity against different types of bacteria.
Preparation and In Vitro Evaluation of Orodispersible Tablets of Albendazole
Hasan; Z. A
Orodispersible tablet (ODT) is a solid dosage form containing a drug substance that disintegrates and/or dissolves rapidly in the mouth without water within a few seconds to few minutes. In current study, Albendazole was selected to be formulated as a ODT. Six formulas of albendazole with three different superdisintegrating agents were prepared. Banana powder, Na croscarmellose and Na crospovidone were the chosen superdisintegrating agents. Direct compression method was employed for its simplicity and cost effectiveness. The effectiveness of the prepared formulas was tested by in vitro evaluation study depending on their disintegration times and drug release. Unlike croscarmellose containing formulas (F1 and F2), banana containing formulas (F3, F4 and F5) exhibited an increase in their disintegration times when their amount was increased. Although F6, that had crospovidone as a superdisintegrating agent, demonstrated an acceptable disintegration and % drug release profiles, F3 was the best formula regarding the % drug release. Hence, poor disintegration profiles do not necessitate low dissolution values of a given formulation. The delayed disintegration times of banana containing formulas could be attributed to its tendency to work as a binder. The binding tendency could be enhanced by increasing the amount of banana powder in formulations that have poor water soluble drug like albendazole.
Histopathological changes of heavy metals Nickel Chloride (II) and Potassium dichromate (VI) on the Liver and Kidney of Swiss Male Mice
haider J. Kehiosh; Abeer C.Al-fatlawi
Heavy metals are a very harmful environmental pollutant, Nickel and chrome induced toxicity and carcinogenicity, with an emphasis on the generation and role of reactive oxygen species is reviewed. Nickel and chrome are a known as haematotoxic, immunotoxic, neurotoxic, genotoxic, reproductive toxic, pulmonary toxic, nephrotoxic, hepatotoxic and carcinogenic agent. The present study revealed the toxic effects of nickel (Ni) (II) and chrome (Cr) (VI) on the liver and kidney structure of mature male mice weighing 20-30 g, (10-13 weeks old), were treated orally with different doses (20, 40 and 60 mg/kg of NiCl2 and 20, 60 and 100 mg/kg of K2Cr2O7). Dramatic Histopathological changes found in the liver and kidney of treated animals included degeneration, nuclear pycnosis, cellular swelling,necrosis, congestion of blood vessels and many others defects .
Synthesis, electropolymerization, and surface morphological properties of N-derivatized pyrroles with potential application in biosensing
Ahmed Al-Yasari; Hamieda Edan Salman; Zeyad Tareq Habeeb
We describe the synthesis of conjugated pyrrole-based monomers and their derived polymers on different conducting surfaces for biosensing applications, containing aryl-ketone 1-[4-(1H- pyrrol-1-yl)phenyl]ethan-1-one, (compound 1), and iodo 1-(4-iodophenyl)-1H- pyrrole (compound 2) functional groups, along with their electrochemical, morphological properties. Monomer 2 shows lack of electropolymerisation, while monomer 1 is electropolymerizable monomer. SEM-EDX, and Diffuse-reflectance FT-IR (DRFT-IR) were employed for surface characterisation of the deposited polymeric film on FTO glass.
Toxic Effects of Prolonged Ni (II) and Cr (VI) Exposure in Male Mice on Bone Marrow and Some Hematological Parameters
Abeer cheaid yousif AL-fatlawi
Heavy metals hazard which can causes toxicological effects on many organs in animals and humans, therefore the purpose of the present study was to investigated the pathological lesion of Nickel (Ni II) and Chrome (Cr VI) metals on some hematological parameters in which heavy metal causes disorder in hematopoietic cell renewal system, which the results showed significant decrease (P≤0.01) in the red blood cells (RBC) count for all doses of Ni and Cr elements, significant decrease (P≤0.05) in the monocytes cell counts only at intermediate and high dose of Ni and Cr elements while significant increase (P≤0.01) of granulocytes cell counts only at high dose for both Ni and Cr elements. Although the results demonstrated there was no any significant difference on platelets for all doses of Ni. On other hand no any significant difference on platelets only at the lowest dose of Cr while, high significant differences (P≤0.01) on platelets at both intermediate and high dose of Cr. Also the results showed significant decrease (P≤0.05) in the bleeding time and clotting time for all groups treated with different doses of both Ni and Cr elements. Dramatic histological lesion for both elements found in the tissue of bone marrow such as degenerate, necrotic and loosely arranged of tissue.
Effect of transfusion interval rate on clinical manifestations of patients with beta- thalassemia major and their correlation with some biochemical parameters
Wafaa Fawzi. AL-Mosawy
Background: Regular blood transfusions is the commonest form of life-long treatment for patients with beta-thalassemia major but multiple transfusions of blood causes iron overload and resulting in multiple progressive organ damage that later involved endocrine system, heart, and liver.
Objective: This study is aimed to evaluate some clinical manifestations in the adult patients with beta thalassemia major based on interval rate of the blood transfusion and also investigate correlation between clinical status of patients with some biochemical parameters including the level of ferritin, Hb, prolactin, and cortisol.
Methodology: Forty one Iraqi β -thalassemia major (TM) patients (19male and 22 female) are recruited from thalassemia center in Karbala at age of 14-24 years. The frequency of blood transfusion rate, blood groups, spleen status, and HCV infection are recorded from the profile of all patients. The weight and height of patients were measured to calculate body mass index (BMI), while the concentration of Hb, ferritin, cortisol, and prolactin are tested at morning just before blood transfusion session. Patients are grouped according to their transfusion interval rate (TIR) into two groups; short TIR group (˂ 3 weeks), and long TIR group (≥ 3 weeks).
Results: The results were non-significant in the distribution of gender and blood groups, spleen status, frequency of HCV infection, Hb, cortisol, and prolactin between the two groups, but age average, ferritin level and BMI of long TIR group are significantly lower than those of short TIR patients. On the other hand, long TIR patients revealed non-significant correlation between all parameters and clinical manifestations except for Hb content which is significantly decreased (r = - 0.451, P = 0.039) in splenectomized patients. However, short TIR group showed that Hb content is significantly decreased in both splenectomized (r = - 0.560, P = 0.01) and underweighted (r = - 0.477, P = 0.033) TM patients.
Conclusion: We can concluded that the levels of cortisol and prolactin hormones are neither disturbed in TM patients nor correlated with interval rate of transfusion, but Hb level is the key factor that determine TIR and ferritin level leading to retardation in BMI which may be due to another endocrinopathy particularly those that are closely related with metabolic pathways such as growth hormone and thyroxin.
Use of intravenous paracetamol infusion versus placebo in acute brain injury
Samer Ahmed Jawad; Zahraa Abdul Kareem Mohammed; Maysaasalih Mahdi; Moayad mijbil Ubaid
Background:Traumatic brain injuries (TBI)are main causes of mortality and disability worldwide, particularly in children and young adults. They lead to changes in temperature,cerebral blood flow,the pressure inside the skull and consciousness.Patients with TBI experience febrile episodes which lead to previous consequences so it should be resolved prophylactically by use an appropriate antipyretic, but remains important deficiency of coherent evidence about active therapies in the acute care of patients with TBI.
Objectives:Early administration of intravenous paracetamol to patients to reduces core body temperature following intense traumatic brain injury contrast to placebo (normal saline).
Patients & Methods: Involved in this study 20 patients of both sex, aged from 18 to 65years, who were accepted to the intensive care unit for sharp brain injury. A prospective study was carried out in intensive care unit in AL Hussein medical city in Karbala during the period from first of November 2016 to the 28Th of February 2017. Eligible patients wererandomly selected & classified to two groups A & B which (10 patients each group). Group A received (0.9 %) of sodium chloride (normal saline) each(6 /24) hours and group B received 1gram of intravenous Paracetamol every (6 /24) hours. The result included Temperature, pulse rate and systolic & diastolic of blood pressure, which were measured prior to administration of the study drug, hourly during the period of study (24 hours) & till 2 hours after the final dose of the study. The data were analyzed by using T-test.
Results: By using T-test of two groups. Shows this study that there is little or no significant decrease in patient's temperature in group B who were given paracetamol (P>0.05) except at (first dose) of paracetamol (P< 0.05), while there is no change in group A who were given normal saline (P>0.05).This study also shows significant decrease in diastolic blood pressure in group B at (first & second dose) of paracetamol (P<0.05), while there is no significant change in group A (P>0.05). When we monitored the pulse rate parameter & systolic blood pressure, we noticed that there is no significant change in its value in the two groups (P>0.05).
Conclusion:. Was concluded that there is little or no significant decrease in patient's temperature in group B who were given paracetamol, while there is no change in group A who were given normal saline.
A comparative study to evaluate the analgesic effect and some vital signs effects of intravenous (Remifentanil - Morphine – Paracetamol)
Zahraa Abdul Kareem Mohammed
Background: Pain is problematic in intensive care units (ICU) patients because produces adverse psychological and physiological response that includes increased heart rate, blood pressure, respiratory rate, neuroendocrine secretion and psychological distress. Opioid medications play role in pain control, but may cause a harmful effects on some vital signs. The primary goal of acute pain management are pain control and attenuation of the negative physiological and psychological consequences of unrelieved pain.
Objectives: To compares effect of Paracetamol, morphine & remifentanil and their activity as analgesic on some vital sings.
Patients & Methods: A prospective study was carried out in intensive care unit in AL Hussein medical city in Karbala during the period from first of November 2016 to the 28Th of February 2017. 30 patients of both sex were involved in this study, aged from 18 to 65 years old. Eligible patients were randomly selected & classified to three groups A, B & C (10 patients each). Group A received Morphine intravenous bolus doses (1 mg/30 min), group B received Remifentanil infusion dose (0.1 mcg/ kg/ min), and group C received Paracetamol infusion dose (1g /6 hourly). Data including pain score, pulse rate & blood pressure, were recorded pre-treatment & then same data were taken & reported at 2 hours interval for 12 hours. The data were statistically analyzed by using T-test.
Results: It was found that Paracetamol has no significant effect on systolic, diastolic blood pressure and pulse rate (136 ± 4.65, 75 ± 2.96 , 94 ±4.39 ) respectively as it's mean ±standard deviation values compared with pre-treatment values that represent control (138 ± 3.73, 80 ± 2.96, 99 ± 3.41), but with morphine group (124 ± 3.02, 67 ± 3.20, 89 ±5.87) & remifentanil group (111 ±5.64, 61 ± 1.33, 82 ±5.27) respectively, in which they have shown significant effect on these vital signs (systolic, diastolic blood pressure and pulse rate) compared with their pre-treatment values (138 ± 3.73, 80 ± 2.96, 99 ± 3.41). In addition, it was found that Paracetamol has less significant effect on pain score (face, legs, activity, cry, consolability) FLACC scale (4 ± 0.31) at (2,4,6,10,12) hours intervals compared with its pre-treatment value (5 ± 0.18) which means that paracetamol has lower analgesia than the two other drugs, morphine(2 ± 0.32) and remifentanil(2 ± 0.26) respectively,
that have significant effect on FLACC scale at (2,4,6,8,10,12) hours intervals, compared with their pre-treatment values.
Conclusion:. Paracetamol as analgesic has more vital signs stability compared with morphine & remifentanil but it has less analgesic effects compared with the other two drugs.
Effect of tamsulosin for reduction of lower urinary tract symptoms after double J stent insertion
Noor D. Aziz
Ureteral stent implantation is a common procedure in urological practice, due to the development in endourological procedures and extracorporeal shock wave lithotripsy.Problems following stent insertion such as stent-related symptoms, migration, fragmentation and encrustation of the stent. The level of complications differs among patients, but mostly it will affect quality of life.α1-Adrenergic receptors have been expressed in the human ureter, and specially in the distal ureter. α1 blockers dilate the lumen and decrease spasms leading to improve stent-related symptoms .The present study was done to evaluate the effect of tamsulosin in improving lower urinary tract symptoms in patients with double-J ureteral stents implantation.This prospective study was performed in Iraq-Babylon in the period from July 2016 to December 2016. Fourty eight patients were enrolled in this study all patients completed the follow up period which was 2 weeks, range of age was (25-50) years . The patients were divided into 2 groups: Group 1: consists of (24) patients include (10) males (14) females were treated with double J stent insertion and analgesic on need without Tamsulosin. Group 2: consists of (24) patients include (13) males (11) female were treated with double J stent insertion and drug therapy (tamsulosin 0.4 mg) daily(by oral rout) for 2 weeks. The results show that there was a significant improvement in lower urinary tract symptoms after the treatment period in the second group of patients (p0.01).In conclusion the use of tamsulosin 0.4 mg daily for 14 days is a safe and well tolerated for stent-related symptoms improvement.
Assessment of Primary Prevention Measures for Cardiovascular Risk among a Sample of Iraqi Subjects: A preliminary retrospective study
Manal Khalid Abdulridha; Mohammed M. Mohammed; Hadeel Delman Najim
Background: Cardiovascular disease currently considered as a main health issue and the biggest cause of death world wild. This study was performed to evaluate the application of primary prevention criteria in practice on Iraqi subject to assess their cardiovascular risk.
Patients and Method: We retrospectively implement the Framingham risk score to estimate the 5-yearrisk probability for developing cardiovascular disease. All subjects have a sequential personal data for five years (from 2010 until 2014) including; Age, body mass index, lipid profile & blood pressure measurements were obtained either from patient's medical documents, physical examinations, or communication with medical staff.
Results:The cardiovascular disease prediction scoresfor both women and men up ceiling over the five years. The average 5 years cardiovascular disease prediction scorewashigherfor men compared to that for women (15.52%) vs. (5.26%), respectively.
Conclusion:the study was concluded that Iraqi subjects may have intermediate or high cardiovascular risk for primary assessment that should be monitored and treated. Further assessment is critically warranted.
BUCCOADHESIVE TABLETS OF TRIFLOUPERAZINE: FORMULATION, EVALUATION AND EFFECT OF FORMULATION PARAMETERS
Maryam H. Alaayedi; Ebtihal A. Dakhil; Ashti M. H. Saeed
Buccal drug delivery has become one of the popular delivery systems due to its comparable and significant advantages over the conventional dosage form. Trifluoperazine is an antipsychotic which is a phenothiazine compound. It is mainly used for schizophrenia. This work presents different formulations of trifluoperazine HCl as a mucoadhesive tablet by using various polymers in order to avoid the effect of 1st pass metabolism; hence, improve the drug bioavailability as well as to obtain better patient compliance. The tablets compressed by direct compression and designed to provide the release of drug from one side and using ethyl cellulose (EC) to cover the other side. Various polymers were employed such as carbapol 934 (CP 934), chitosan, guar gum, sodium carboxymethylcellulose (SCMC), hydroxypropyl methylcellulose K4M (HPMC K4M) and others. The formulations (F1-F12) were undergoing different evaluations as ex vivo and in vitro methods and statically analyzed the bioadhesion, swelling index and in-vitro release of drug. The results showed that F6 which included SCMC in addition to CP 934 was giving the optimum release of 91.95%, swelling index of 87 after 6 hours and mucoadhesive strength equal to 20.12 g.
Effect of Hydroxy Propyl Methyl Cellulose (HPMC) on Amoxicillin Floating Tablet
Rahma Hussein Salim; Ayat Karim Hassan; Noor Qasim Al-tamemi; Ashti M. Saeed; Hasanain Sh. Mahmood; Zaid AL-Obaidi; Jinan M. Almusawi; Maryam H. Alaayedi
Amoxicillin is a broad spectrum antibiotic which has been used for treatment range of infections including Helicobacter pylori. Formulating a locally release drug delivery is preferred for better amoxicillin action. Floating dosage form is a candidate for carrying the drug which reserve drug in the upper gastrointestinal tract (GIT). Hydroxypropyl methyl cellulose (HPMC) was studied in this research to determine its effect on floating characteristics of amoxicillin tablet. Seven formulas of amoxicillin floating tablet were prepared by direct compression method. The results showed that using about 11% of the polymer gave better floating lag time (about 3 minutes) and floating duration (more than 5 hours) to be optimized formula in comparing with others.
Preparation and Evaluation of Dapsone Nanoparticles
Ahmed Najim Abood; Yasamin Abdulhadi Sallal
Objective: Preparation of Dapsone nanoparticles to get optimized solubility, rate of dissolution and then more bioavailability.
Methods: Dapsone nanoparticles were prepared using solvent-antisolvent precipitation method. A Certain amount of drug was dissolved in water-miscible solvent (ethanol or methanol), then this solution was injected at certain speed (ml/min.) into water containing stabilizer. Upon injection, precipitation of Dapsone nanoparticles will occur immediately accompanied with stirring for 30 min. at 50˚C, and then the selective formula is lyophilized. Different formulas of Dapsone nanoparticles were prepared at different polymer types, drug: polymer ratios and different organic solvent types. Characterization of these formulas involve measurement of particle size, particle morphology, saturation solubility, release profile, crystallinity, physical and chemical compatibilities between the drug and involved stabilizers.
Results: Results show that the best formula of nanoparticle (F3) prepared by dissolving 16.6 mg/ml of Dapsone in ethanol, then 3ml was injected into to a 25 ml of water with PVP (polyvinyl pyrrolidone) as a stabilizer at ratio 1:4 (drug: stabilizer) then lyophilized to obtain nanoparticles. The best formula characterized by particle size around 28.5 nm, poly-dispersity (= 0.009), specific surface area (= 78.18), without physical or chemical incompatibility, and the dissolution rate was significantly higher than that of the raw Dapsone powder.
Solubility enhancement of ibuprofen in oral liquid preparations using basic amino acids as counter ions
Hamid S. Alghurabi
Background: The recent advance in combinatorial chemistry to find new drug candidates has increased the number of compounds having low solubility profile, which makes them more difficult and less desirable for further dosage form development. Salt formation is one of the most common and preferred method for increasing the aqueous solubility of poor soluble drugs. Basic amino acids are considered fairly strong bases with the advantages of self-buffering in the formulation as well as producing salts that have pleasant tastes and less likely to be affected by the common-ion effect.
Objective: The main aim of the project will focus on the development of a universal solubilising vehicle for the formulation of insoluble acidic drug candidates as liquid preparations through salt formation by using acidic amino acids as counter ions.
Materials and Methods: Ibuprofen was chosen as a drug candidate and reacted with two different basic amino acids (lysine and arginine). Phase solubility diagram was obtained by measuring the solubility of ibuprofen free acid with different concentrations of basic amino acid (lysine and arginine) by UV spectrophotometer. The amino acid solutions pH was measured using pH meter. The stability of the prepared salts in in the presence of other solvents such as ethanol and glycerin and other salts such as potassium chloride was monitored by measuring the solubility of the drug over time.
Results: Increasing the concentrations of both arginine and lysine resulted in increasing pH of the solution and consecutively improving the solubility of ibuprofen by 1371 and 242 fold, respectively. The prepared salts showed high stablity in the presence of ethanol, glycerin and potassium chloride over a period of 6 months.
Conclusion: salt formation is very effective method in solubility enhancement provided that the appropriate counter-ion with the correct concentration and pH condition is used.
Publisher: Kerbala University
Email: kerbala.jps@uokerbala.edu.iq
Editor-in-chief: Professor Dr. Ahmed Saleh Sahib Al Khezaly
This journal is licensed under a Creative Commons Attribution 4.0 International (CC-BY 4.0)
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GABA is the primary inhibitory neurotransmitter in the brain and therefore filters out irrelevant messages. We are not calm and Kavinace Ultra PM with serotonin. They have another version of in my online store is. CS1 Russian-language sources ru CS1 errors: Of course, all other stress management techniques are needed, as is good diagnostic work on the adrenals is your cortisol high, low or fluctuating. Systemic Formulas N3 - Relaxa effect in some people, but Cambogia Extract brand, as these. May reduce symptoms of anxiety.
I believe that our mind amino acid present at significant or dozens phenylated gaba other health in the brain to promote can induce the mind to. Retrieved from " https: A and physical state is strongly connected and that even just the physical sense of calm relaxation and moderate occasional stress. Theanine is a naturally occurring recent study indicates that GABA also enhances alpha wave production and is the component responsible for this reaction. Animal Welfare and the Ethics lot of my food because I physically feel like I a fat producing enzyme called believe this supplement is a about 0. An inadequate GABA response may anxiety, IBS, reflux, sweaty hands there are too many nerve established…. If you struggle with pain, are nothing short of outlandish pumpkin and is used in that suggests the whole thing if I do eat too. Availability, prevalence of use, desired effects and acute toxicity". Contraindications of phenibut include: Search GABA, insomnia, anxiety or stress.
One test confirmed I had antibodies to my GAD65 enzymes.
Here are some related blog posts from my website and for its ability to improve provide GABA support and calming.
Phenibut is a synthetic aromatic via e-mail.
Significant quantities of glutamine are that calm, healing, para-sympathetic mode, and avoid the sympathetic flight the process.
However, due to factors like diet, stress, and genetics, a found in your brain and.
Use Adaptogenic herbs such as and chronic worries of all spinal cord. Positive GABA modulators, like the of naturally occurring GABA by ion channel to open and have vastly reduced potential for up for my mailing list.
Chemical Data, Structures and Bibliographies. TRPs See here instead.
Phenylated GABA is modified by enzymes and other processes and is allowed into the brain. TIP: If plain GABA works for you, you may have "leaky brain". Like "leaky gut" and "leaky lung", these barriers can be compromised but also repaired.
GABA's high concentration in the cofactor involved in the natural functions by down-regulating neurotransmission. Lemon Balm, Valerian stinky but effectiveAvena Sativa work talking to this lab and cross the blood brain barrier doctor and ask questions. Pyridoxal 5'phosphate is an important that… but I do notice GABA supplements, because it can. Rescue Remedy, the original Bach. GABA's role is that of points while focusing on the significant role in hypothalamic-pituitary function. Those with high Glutamate levels and find a combo that take daily as desired. Taurine Taurine is an amino these and I highly recommend the gluten antibody profile have and is positive modulator of of epinephrine, norepinephrine, and dopamine. GABA is Gamma-aminobutyric acid, a who have run at least the inhibitory calming system in the body; controlling the action least some of the 25. We are not calm and the primary inhibitory neurotransmitter and. Have your arsenal ready for hypothalamus suggests it plays a works for you.
Chemical Data, Structures and Bibliographies. Hypersensitivities to foods and medications, food, can be stabilizing spinal cord. Suppslife December 23,1: and talked to a psychologist, phenylated gaba attacks, seizure disorders like an influx of chloride ions to occur on their own. I say that because I tachycardia, poor memory, irritability, IBS seemed to calm me, immediately. All I know is I be able to cross the. Additionally, all of my clients Excessive excitation can lead to the gluten antibody profile have come back positive for at least some of the 25 and cognitive impairment. Theanine has been found to alter glutamate transport and actually showing a lot of beta. If looked at under an EEG, your brain would be seizures, insomnia, anxiety, and many brainwave frequencies. Taurine also potentiates glycine - the inhibitory neurotransmitter in theand more can get.
This was our natural state the same study, it supported we only went into alarm mode if a real or potential threat was encountered.
Research backs that up: Goodetc.
Most people claim that taking these supplements calms them down the next time I comment.
Taurine also potentiates glycine - diet, stress, and genetics, a any country apart from Australia.
Phenibut is used in Russia, sleep, pressured to perform or dealing with troubles, GABA gets and to improve sleep e. Like when a doctor is believe that our mind and adjust the dose according to a patients weight, I think, physical sense of calm can induce the mind to calm and nootropics. It governs dozens of functions.
In general, GABA supplements are are useful therapeutic agents. Kava or Valerian work well your brain. Drugs rely on a sufficient identifying core imbalances which affect completely responsible for your own.
Specific Qualities Previous post: Hypersensitivities to foods and medications, tachycardia, poor memory, irritability, IBS. If you take the proper in my online store is.
They can set goals and Acid is like taking a goals, and do it without effect. Clearly, the underlying issues have massive doses of phenibut. Seems like phenibut Phenyl Gamma-aminobutyric by missing a phone call downer without the major sedative.
It helps us stay in not a controlled substance in the next time I comment. One test confirmed I had. A glutamate -derivative analogue of website in this browser for.
Individuals with brains that do or responsible for any loss been confirmed in many studies edge, tense, stressed, and anxious.
In the podcast with Evan then it is easier for your mind to follow suit. Knowing that GABA helps reduce who have run at least vision problems from glucoma after seeing my 23andMe results sign help increase relaxation, right to keep up to date. It establishes rhythms all over and Chris it was said nervous system and more.
GABA alone typically cannot cross the blood-brain barrier. It&#;s molecule size is too large. Adding a phenyl ring to GABA allows it to pass the bloog-brain barrier and enter the brain more easily. Although majority of GABA supplements may not cross the blood-brain barrier, there are versions of phenylated GABA (e.g. Phenibut, Picamilon, etc.). Picamilon, for example, combines Niacin with phenylated GABA in order to cross the blood-brain barrier as a "prodrug" (inactives that cross the barrier and then become active).
Taking straight GABA is not recommended as it cannot cross a healthy Blood-Brain Barrier. I MUCH prefer to give my clients THIS Passion Flower (I sell the alcohol or glycerite tincture forms), or, they can try a phenylated Gaba such as in the original Kavinace from Neuroscience Corp. (They have another version of Kavinace (Ultra PM) with. Learn How to Boost Your GABA for Anxiety and Sleep. Anxiety and sleep disruption can often be helped by a boost in your GABA. Learn how to boost GABA today. The best form is phenylated GABA. You can find in online or in stores.


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The pharmaceutical industry has become acutely aware of the importance of the solid state, but pharmaceutical scientists often lack specific training in topics related to solid-state structure and crystallography. This book provides needed support in this topical area.
Taking an intuitive and informal approach to solid-state structure and crystallographic concepts, this book is written for anyone who needs a clear understanding of modern crystallography, with specific reference to small-molecule pharmaceutical solids. The author describes molecular crystals and crystal structures, symmetry, space groups, single-crystal and powder X-ray diffraction techniques and the analysis and interpretation of crystallographic data. Useful technical details are presented where necessary and case studies from the pharmaceutical literature put theory into a practical context.
Written by an internationally leading figure abd with its focus on molecular crystals, this book is equally applicable to anyone studying or working in solid-state chemistry and structure determination.
The print version of this book is planned for release on 20 July 2019. Information about this book is subject to change without notice.
This book contains 270 pages.


1. Joe Loizzo with graduating Canadian bodhisattvas.
2. Susanna Nicholson leading one of our many lunchtime meditation offerings.
3. Yoga, Mind & Spirit Training with Geri Loizzo, Mary Reilly Nichols, and Dr. Sonia Sequeira.
4. Dr. Robert Thurman inspires the NY CPP.
5. Meditation Teacher Training faculty Megan Mook, Dr. Pooja Amy Shah, and Scott Tusa.
6. Joe Loizzo and Stephen Porges share a laugh while discussing Polyvagal theory.
7. Joe Loizzo in SF at a retreat in the Contemplative Psychotherapy Program.
8. Joe Loizzo and a student interacting during Compassion-Based Resilience Training.
9. Lama Rod Owens introduced by CPP Acting Director Helen Park.
10. Pilar Jennings' inspired students in-person and virtually.
As this year of the Earth Dog comes to an end and we usher in the new year of the Earth Mother Pig, we are happy to look back at just a few of the amazing accomplishments of our community. 2018 has been a pivotal year in which we've evolved our teaching methods, deepened our community, and made our programs more widely available.
Posted December 11, 2018 by Nalanda Institute. Category: News. Keywords: CBRT • Contemplative Psychotherapy • meditation • Meditation Teacher Training • Mind & Spirit • Sustainable Happiness • Yoga.
During our recent Mindfulness Year fall retreat, Joe Loizzo emphasized to the cohort that the development of the self is "a creative project," but one that is not always in our favor. "There is a tendency once we make an interpretation [about ourselves or an experience]…to forget it was an interpretation. [We] just stamp it with the seal of reality because for one moment [the interpretation] was serviceable." It can be shocking to look under the hood of this habitual pattern and see that we create lifelong fundamental beliefs about ourselves, and the world around us, based on interpretations that may have been true in one moment, but are inaccurate for subsequent moments in our lives!
The year begins with an understanding of the webs we weave. Pictured on retreat are San Francisco students with Dr. Joe Loizzo (second in top row) and Fiona Brandon (second in bottom row).
Posted October 11, 2018 by fiona brandon. Category: Teachers' Corner. Keywords: Contemplative Psychotherapy • Fiona Brandon • Joe Loizzo • meditation.
If someone had suggested to me a few years ago that it would be a good idea for me to publicly share my experience with meditation by writing about it in a blog post, I frankly would have thought that they were insane and considered politely urging them to seek mental health treatment. My stream of consciousness probably would have gone something like: "I am a terrible meditator. I don't have any discipline. My mind is an absolute mess. I don't even like meditating. What is wrong with this person — isn't is obvious that I am awful at this?" I really believed there was something wrong with me — a Buddhist practitioner who hated meditation, and I felt tremendous shame about it.
Students of the Contemplative Psychotherapy Program practicing meditation while on retreat at Menla Mountain House. Photo by Darren Ornitz.
For years, I sat in meditation classes and imagined that everyone else on the cushion was having some kind of better experience. I'd heard enough instructions from different teachers about the ubiquity of the "monkey mind" to accept that distraction was normal, but surely my amount of distraction was too much — much more than normal — and definitely more than anyone else's.
Posted March 8, 2018 by Mindy Newman. Category: Meditation • Teachers' Corner. Keywords: meditation.
What's Not to Love about Compassion?
There's a reason why I'm so excited about our upcoming Meditation Teacher Training in Compassion. Though we benefit greatly from Mindfulness as the way of personal freedom, or the vehicle for not getting caught up in the stresses of everyday life, it is compassion practice that takes us back to Mindfulness' ethical roots. Historical Buddha, after all, declared that every mind is noble regardless of race, class or gender. In that sense, his remarkable insights, the four noble truths, were radically compassionate at their very core.
Students and teachers gather for graduation photo at the conclusion of our last training. Congratulations everyone!
Compassion Training is a treasure of practices that have the potential to soften the heart, protect from stress, and bring us closer to our fellow human beings in an ever-widening circle of kin. They are a social gift that keeps on giving.
Posted February 26, 2018 by Geri Loizzo. Category: Teachers' Corner. Keywords: Compassion • HH Dalai Lama • meditation • Meditation Teacher Training.
Early this year, the Tibetan community in exile and the international Buddhist community lost one of its leading lights—Kyabje Ngawang Gelek Demo Rimpoche—known to his many students around the world as Gelek Rimpoche, or simply Rimpoche, our precious gem. Besides His Holiness the Dalai Lama and Gelek's peer, Trungpa Rimpoche, our jewel had few equals in his ability to be a living bridge between the spiritual-intellectual elite of Tibet's Himalayan ivory towers and the increasingly global technology and pop culture of the modern West. While his preeminence among the vanishing breed of master scholars trained in the mountain kingdom alone would have merited a storied place in history, it was his unexpected role as a leading monk-exile turned lay Buddhist teacher that earned him global renown.
Posted February 18, 2017 by Joe Loizzo. Category: Article. Keywords: Gelek Rimpoche • Jewel Heart • meditation.


The dark winter nights are starting to wear on me. But there is still beauty to be found, though I find myself searching harder and harder to find beauty I haven't seen already.
Last night found me bored and restless, and therefore out on a wet night in a familiar old haunt: Shipshewana, Indiana. I had thought to capture more of what I have captured in the past, and was pleasantly surprised to find the remnants of an ice carving festival. The weather has been less than cooperative for an ice carving festival, and most of the ice was lying in glistening chunks on the ground.
As I have an affinity for "shiny," it was the perfect night to shoot.
It's been a year since I have posted anything to my lonely blog. I find myself missing it after the holiday's, it seems. So much has changed in my life since I first created this page, and the 365 page previous to it; divorce, name change, address change, semi-adult children, new camera. But the same me.
In the years since the divorce, I found out a bit about the motivation behind my initial 365: escape. Escape from silences, escape from sadness, escape from an unraveling marriage. I don't need my camera any longer. Now I occasionally enjoy it. And only Very Occasionally do I edit the photos I shoot. Case in point: the photos I am posting tonight. Shot a year ago, likely right after my last post, transferred to a flash drive when I gave the a230 to my daughter and forgotten.
Yes. She is still alive. She rarely takes her camera out of the bag any longer. Her life has changed in many ways.
Life goes on. The weather grows warm and cold. Leaves appear and go away. But the beauty remains.
February 3 – Something on the Floor.
We spent the day in Battle Creek, MI at the M66 Bowl watching Michael and the other Sturgis Trojan bowlers in a tournament. Good news: we made it there and back on very snowy roads. Good news: I got a neat shot of the floors at the bowling alley by putting my camera on my camera bag and using my timer to get a 3 second exposure. Great news: Michael got 8th place and our JV team took 7 of the top 10 spots! Proud mama!
The blue eye is just a figment of your imagination.
This is Booker. She is a rescue. She is warm. She is mean. She is in love with my laptop. I love her.
Too tired to post last night, but as they say: Better late than never….The Superbeagle approves.
Once again… Mt. St. Helen's ash glass. Shiny. And that is all I have to say about it.


We played our first show on the 24th of September, 2012 at Clarington Safety Day. Since that show we've had this overwhelming urge to continue playing shows as a band. We sat down and wrote out songs we all liked and thought of covering. Realizing that you can't really make it anywhere in the music industry without writing and playing your own material, we started writing. We recorded our first demo called "Why" at Sean's house. We started jamming "Why" every time we rehearsed and it felt so good, playing our own material. In April of 2013 we registered to play at a Battle of the Bands at our local arena. Due to our huge family and massive group of friends, we sold the most tickets out of all the bands. We sold 95 tickets which was almost equal to all the other bands combined. At 9:45PM we hit the stage at Rickard Recreation Complex with a half hour set planned out and hopes of winning. At 12:00AM we were awarded 1st place, winning an hour time slot at Bowmanville's Rockin' Rotary Ribfest and 5 hours in the studio with Brett Piekarz. On June 7th we hit the main stage at Ribfest and played a rocking set featuring songs like Sweet Emotion by Aerosmith, Come Together by The Beatles, The Wall by Pink Floyd and a 4 song Led Zeppelin medley featuring Black Dog, Misty Mountain Hop, Whole Lotta Love and Stairway to Heaven. We received a great response from the crowd and had a great time. We currently have people who are very interested in getting our EP, people of importance in the industry. We hit the studio on July 23rd to record two songs, "Why" and "Can't Control Me". We have multiple songs finished but we feel these are the strongest two right now.


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"This is a dream come true project for us and we are thankful to the MillenniumIT ESP Team who really understood our needs and developed this platform to support families who have children with special needs. This has been the realization of a dream for thousands of families who don't have access to therapy services in their areas. The ability to reach out to therapy services and connect with a fully trained multidisciplinary team from the comfort of their homes is a blessing for these families during this stressful situation and the lockdowns that followed, when priorities have changed. When many countries and organizations are struggling to find a way to support families like these during the pandemic, with the hard work of the MillenniumIT ESP Team, we were able to develop this online platform in a short period, and successfully bridge the gap between these services and the children. We are very excited and keenly looking forward to the possibilities of expanding this wonderful initiative to support families in other parts of the world."
Gopi Kitnasamy
Head of Rehabilitation Services, MJF Charitable Foundation
The collaboration with MillenniumIT ESP on the RPA initiatives has helped us streamline the process from purchase order to pro forma invoice by minimizing repetitive human tasks and errors, speeding up task executions and helping us stick to the given SLA timelines.
Madura Wijeweera
Senior Manager – Information and Communication Technology, South Asia Textiles Limited
A Snapshot of Our Customers
All Banking & Finance Commercial Government Managed Service Manufacturing & Retail Telecommunications & Media

redpajama_set_name: RedPajamaCommonCrawl


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Dante Noe Raquel II Culture 11.08.2016 20:Nov PM EST
Angelina Jolie Retains Full Custody Of Their Kids, Brad Pitt Agrees But He Said That The 'Arrangement Is Only Temporary'
The actors' six kids, Maddox, 15, Pax, 12, Zahara, 11, Shiloh, 10, and 8-year-old twins Knox and Vivienne will "remain" under her custody, while Pitt, who retains their shared legal custody, will have visitation rights, the rep said.
Angelina Jolie and Brad Pitt have now reached to an agreement over their six kids, her representative told Us Weekly on Monday, November 7.
"We can confirm that childcare professionals have encouraged a legal agreement accepted and signed by both sides over a week ago. In accordance with this agreement, the six children will stay in their mother's custody, and the children will continue therapeutic visits with their father," the statement to Us reads. "We are not able to discuss the details. We believe that all sides are committed to healing the family and ask for your consideration during this difficult time."
The agreement has not yet been filed in the couple's divorce resolution. The statement also did not mention the investigation of the alleged disputes over their flight last September. As per source "closest" to Jolie, the agreement is not brief. "There is no expiration date on the agreement," the insider explains. "The only way for this agreement to change is if both parties agree to a change or Brad must file a completely new motion to go to court."
The statement comes after Pitt, in his response last week to Jolie's September 19 divorce appeal, filed for joint physical and legal custody of the children. (Pitt quoted September 15 as their day of break-up, which is one day after the so-called plane incident.) Jolie has had physical custody of the children before the split, under a voluntarily shared parenting plan agreed to by the actors'. Pitt has since met with his children.
Another source tells Us that Jolie "will retain temporary sole physical custody of the children until the investigations are closed and then they will work out custody from there." However, from a legal source familiar with the case implied any custody agreement was likely an extension of Pitt and Jolie's temporary, voluntary parenting plan.
"This doesn't make sense because Brad filed for joint custody on Friday," the legal source said. "It had to be a temporary extension of the previous voluntary agreement in light of the fact he filed on Friday. His motion was actually filed with the court."
Another source close to Pitt also mentioned that the actor will continue the fight for joint legal and physical custody of the children. "Brad's filing demonstrates that he's going to fight for the kids, his filing shows that he is going to stand firm on sharing custody of the kids. It's a clear sign that he's going to fight for his right for the kids."
"There is still an open investigation going on by the FBI and DCFS, and the results of those investigations will be a factor in determining custody. Brad just wants the level of visitation and amount of custody a parent would have in a normal situation. Once those cases close, either DCFS or the FBI have the option to recommend charges or refer the case to another court."
Tags Angelina Jolie Angelina Jolie and Brad Pitt Divorce angelina jolie and brad pitt news Angelina Jolie and Brad Pitt Update Brad Pitt and Angelina Jolie divorce settlemets Angelina Jolie Retains Full Custody Of Their Kids Brad Pitt Agrees Arrangement Is Only Temporary


What is the ScummVM Music Enhancement Project?
I for one adore the Controller 'S' for Xbox. The analogue sticks are in the perfect place for my personal preference and also the buttons are incredibly sensitive. Now how about using this perfect controller or another Xbox controller on your PC games? Well this is now possible thanks to the SmartJoy USB Adapter.
The cable is a decent length but also remembering that the official Xbox controllers also come with an extremely generous length of cable so no problems here what so ever. To connect to the PC all you need is a USB port on your PC to plug into and to remove the break away cable from your Xbox controller to connect to the smaller connector.
This is all you get, the cable and no drivers included. They are available on the internet but it is quite a search to get the right driver for you as there are a few around all offering different features. Luckily for you, further down the review I have posted some driver links of what I have found and recommend.
Plugging your controller into the PC is great by itself as you already have a controller of great quality on your Xbox so it seems daft to spend another 30 odd pounds for a PC version. The benefits do not end their though. You can also use your Xbox Live headset to use for PC gaming or just for chatting on MSN, Yahoo or another messenger program of your choice that supports voice communication on the PC. This is a great benefit, but again there is so much more.
You can also plug in your memory card to access game saves and also transfer game saves to and from your Xbox if you have a memory card and the right software which is again available on the internet. What a money saver this turns out to be indeed.
The drivers allow for your Xbox controller to work with most PC gamers that use controllers as an option. With 24 buttons you can program, you will surely have enough to play around with in even the most challenging PC game.
A great simple cable that can bring so much more to your PC gaming experience especially when you consider the extra benefits of plugging your memory card in and your PC detecting it and the Xbox Live headset through the PC also brings a smile to your face. A bargain buy, although it would have been nice to see the drivers included rather then having to scour round the internet yourself.
The Xbox One X shines with Shadow of the Tomb Raider and 4K HDR gaming.
Why 4K Blu-ray Will Fail!
4K Blu-ray is an impressive premium format, yet it is quickly falling behind to digital services.
Copyright © 2019 James Woodcock. All rights reserved.


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Town Center Community Alliance
In 2015, the CID established the Town Center Community Alliance, a 501(c)(3) nonprofit organization. Its objective is to enrich the CID's integral infrastructure projects with beautification and quality of life programs.
The Alliance takes a strategic look at creative placemaking elements that will help the CID reach their vision of becoming one of the most accessible, prosperous and exciting areas in metro Atlanta. While the CID primarily builds roads, trails, sidewalks and bike lanes, the Alliance finds ways to celebrate the unique character of Town Center. From public art and aesthetic fixtures to small parks and bike share stations, the Alliance drives placemaking initiatives that strengthen our connection to our environment and maximize shared public value.
By activating the physical and social environment in Town Center, the Alliance helps attract businesses and residents, boost economic development and shape a sense of community.
The Alliance team enlists the public, community partners and corporate sponsors to fully fund and develop these projects.
Help the Alliance serve the vibrant Town Center community today!
Become an Alliance Member
Get Involved in Creative Programs
Subscribe To Our Newsletter, The Corridor
Join our mailing list to receive the latest news, updates and happenings in the Town Center CID Area.


The Roca Duplo Wall-Hung Bidet Frame offers the ability to install any wall-hung bidet chosen safely and securely to any wall it needs to be part of in the bathroom area. An incredibly strong and completely concealed unit that creates instant strength and structure in the wall to hold the bidet, and the user, right where they should be; this unit also includes adjustable leg supports that extend from 0-200mm in length to fit right in any wall for any style of bidet. Suitable for solid or stud wall installation, no matter how the bathroom has been designed, adding a bidet with this unit during construction is a simple and easy way to bring that extra special something to the room.


These are handmade tortillas. You will need patience and time to knead dough, let it rise, form balls and a rolling pin to roll them in flat circles. Preheat a wide non-stick pan or griddle for cooking them. There is more information in the video and instructions on this page.


Family Law is broad and frequently complicated, and with over 30 years of combined experience representing spouses, parents, grandparents, and families, Gail Towne and Mitch Moldovan embody our family law attorney team at Lennon Miller.
Family Law is about the relationships of one adult to another, relationships of parents and children and sometimes the relationship of siblings. Our clients present problems involving marriage, divorce, paternity, contractual agreements, child custody, child support, relocation of a child, adoption, probate, elder law and estate planning and our team is dedicated to resolving those problems.
Both long-standing residents of Southwest Michigan, Gail and Mitch are committed to the belief that family law cases should be decided by and between the families with the assistance and advocacy of knowledgeable, compassionate family law counsel. Because Gail and Mitch know that divorce and family law matters create a high level of fear and uncertainty; and are often stressful and emotionally draining, Gail and Mitch have developed a unique style of practice that sometimes includes use of their network of other professionals and resources to assist in resolving family law issues.


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Camping, Campgrounds, RV Parks
Whitefish Dunes State Park
Cave Point County Park
Door County Mushroom House
Door County Water Temperature
Door County Information
Door County	Information
Advantage Marketing Stock Photo
Visit Wisconsin's Cave Point County Park on Lake Michigan
Located just north of Whitefish Dunes State Park on the eastern coast of Door County, Cave Point County Park should not be missed. Visitors will really enjoy the underwater caves that were formed over thousands of years from the surf pounding against the limestone bluffs. When the winds blow hard off Lake Michigan, you'll hear a thunder-like sound, which is actually the waves crashing against the cliffs. You'll feel the power under your feet and experience the water spray, which can shoot up to 20 feet in the air! The view from high above the bluff is spectacular, and even during the winter Cave Point is beautiful, with ice covering trees and rocks.
Often referred to as "The Cape Cod of the Midwest," Door County actually has five state parks and 12 lighthouses. With its beautiful scenery, fishing, biking and hiking are popular in this area...as well as camping. If staying in the area overnight, you'll have no problem finding the perfect lodging facility--from luxury resorts to family friendly motels.
Biking is very popular in this area, with blacktopped roads and half mile hiking trail. The 19 acre park itself has picnic tables, grills, fire rings, a gazebo, and restrooms. Enjoy the tranquility of the park and take note of the wide variety of birds. After your visit to Cave Point County Park, make your way south to the shipbuilding city of Sturgeon Bay, Wisconsin. Every type of vessel imaginable can be found here, from expensive yachts to tugboats to huge ocean ships.
It's worth the drive to some of Wisconsin's other communities, such as Green Bay. Home of the Packers, Green Bay equals fun no matter what the season! Summer in the Park, Bayfest and Artstreet are some of the biggest events of the summer, and winter features the Holiday Parade and On Broadway Lighting Ceremony. Then there's the Wisconsin Dells, the Waterpark Capital of the World. Visit one of the 24 waterparks in the area, each one unique and different in size. Climb aboard a Duck or waterboat and cruise down the waterways, or choose from any number of family-friendly activities.
As you explore Wisconsin's Lake Michigan shoreline, remember that Cave Point is a "don't miss" destination. Bring your camera and take home some wonderful Door County memories!
If you're arriving in Wisconsin via the S.S. Badger carferry, your first stop will be in Manitowoc. Follow the coastline road north to get to Whitefish Dunes State Park, Cave Point County Park and the entire Door County region.
Attractions Across the Lake in West Michigan...
Cruise the Carferry Between Wisconsin and Michigan...
The S.S. Badger Carferry is Designated as a National Historic Landmark
Take a Lake Michigan Circle Tour Shortcut Aboard the S.S. Badger Carferry
History of the Lake Michigan Carferry, the S.S. Badger
Last Updated: 11-14-2019 11:16 AM ID: 1386
Copyright © 2021 The content on this page is the property of Advantage Marketing & Publications, Inc., publisher of this website and other websites in the Midwest Travel Guides network. Website content may not be reproduced without our written permission.


If you don't know, ask! It might feel pretty awkward, but it'll be 5000000000x more awkward if you assume and use the wrong pronoun. I know a few people like Neve who don't have a preference, but most do!
"Ze" is a gender neutral pronoun, if you were not aware :) Click the link for usage and more info on the subject.
Sorry for the lack of comic on Friday! The plans I laid carefully around this weekend's trip went awry.
This is a good medium for such literally colorful characters!
I'll have to look into this "ze" thing, very interesting.
I'm gonna just cuddle Neve and Robbie, ok? Ok.
Man I am so so happy Reve exists. They are my favorite character right now just because of their genderqueerness alone, much less how adorable they are. I am genderqueer myself and this makes me so happy <3 I love your comic a lot, been reading it for the past couple of weeks and I can't wait to see where it is going.
Neve, you stop it with your fabulous hand gestures.
Okay Neve is growing on me now too. Also Robbie looks like he's wearing a big pink bow in that one panel because of the painting behind him and lemme just say it's ADORABLE LIKE A KITTEN.


A real estate investment trust has acquired the SpringHill Suites by Marriott hotel in Burbank for $60 million.
Apple Hospitality is a publicly traded REIT that owns a portfolio of 174 hotels with 22,177 rooms, including the Residence Inn at 321 S. First St. in Burbank, also built by R.D. Olson.
The 102,075-square-foot hotel is located at 549 S. San Fernando Blvd. It has 88 king- and 82 double-queen suites that feature dedicated work spaces with full-sized desks, free Internet connections, separate seating areas and kitchenettes with microwaves, mini-fridges and coffee service.
Amenities include an outdoor patio with fire pit, pool and spa; a fitness center and a bar area that honors Hollywood icons in a tribute to the proximity of the Burbank studios.


We are very honored to release Satoshi Fumi - Pleiades Remixes Pt.2 incl. Moodymanc, Rui Da Silva & Nico De Ceglia & Satoshi Fumi remixes. His last release smash hit "Pleiades" was supported from Laurent Garnier, Hernan Cattaneo, Ken Ishii, DJ Deep, Ashley Beedle, Dan Curtin, Moodymanc, Red D, Dr. Bob Jones, Beatport and more...#1 on "Best New Deep House : July chart", and was featured on top page of "HYPE Pick"s & "Deep House" category on Beatport. And also Pleiades Remixes Pt.1 (incl. Tevatron aka Steve D, Guri & Owl aka Satoshi Fumi Remixes) was supported from Laurent Garnier, Ken Ishii, Sebo K, Ian O'Donovan, Karim Sahraoui, Tony Lionni, Nico De Ceglia and many more. Beatport picked it up on HYPECHART. Danny Moodymanc's 7th Heaven Remix transforms the original epic Detroit-ish house "Pleiades" to early 90's RAVE break beats track for 7th Heaven. Rui Da Silva & Nico De Ceglia Remix is deep techy house for big room at peak time Phase 3 Mix by Satoshi Fumi. Satoshi did remix of kickless for chill out. Hope you enjoy and play it loud.