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Periodically, we feature articles by diverse authors about their experience of doing business with Mongolia, reports about some of our events, and important speeches from public figures about the country.
Mongolia and the Financial Action Task Force
By John Grogan
Mongolia has a world beating record on combating the coronavirus with currently no recorded deaths. Moreover, the Mongolian Government has suspended all commercial flights into the country for the last six months. All the more noteworthy then that last week a Mongolian Airlines plane took off from London Heathrow bound for Ulaanbaatar for the first time since 2013. Seven years ago, the passengers were the military band of the Mongolian army heading home after a successful debut at the Edinburgh Tattoo. This time on board were five representatives of the Financial Action Task Force (FATF) with a mission to Mongolia of crucial significance to the nation's economy. Experts from the U.K., USA, Japan, China and Russia were considering whether Mongolia should be removed from the organisations grey list.
Based in Paris the FATF is an intergovernmental organisation founded in 1989 on the initiative of the G7 to develop policies to combat money laundering. Since 2000 FATF has maintained a blacklist and a grey list. Like the blacklist, countries on the FATF grey list represent a much higher risk of money laundering and/or terrorism financing but unlike those on the blacklist they have formally committed to working with the FATF to develop action plans that will address their deficiencies.
Dulguun Bayarsaikhan writing in the UB Post in October 2019 summed up Mongolia's recent relations with the FATF which resulted in the nation being added to the grey list for the second time in 2019.
'Mongolia entered FATF's grey list in 2013, but narrowly slipped out of it with specific conditions as the country managed to meet some of the requirements and made specific commitments.
In 2016, FATF strongly urged Mongolia to enforce the laws with a set of recommendations. The recommendations included enhancing economic transparency, improving oversight on the financial market, and holding those who break laws accountable. Complying with the recommendation, the Mongolian government formed the National Council to Combat Money Laundering and Terrorism in April 2017.
However, failing to produce the desired outcomes, Mongolia was put under strong scrutiny from the FATF.'
The importance of getting off the grey list to the people of Mongolia is clear from the fact that last week the Prime Minister, Finance Minister and Chairman of the State Great Khural (Parliament) separately made presentations to the FATF officials socially distanced behind screens in the Kempinski hotel. Mongolia has borrowed heavily on the world's bond markets over the last decade and between 2021 and 2024 much of this will come to term. Refinancing costs will be much more affordable if the country can establish a reputation for financial integrity and honesty.
The signs look promising that the Government under Prime Minister Khurelsukh which has recently achieved a stunning election victory is prepared to walk the walk as well as talk the talk. Substantial progress seems to have been made on implanting the necessary technical regulations. There is also the need to ensure that for the first time there are the institutions with the resources available to implement the law and the fearless independence to do so. This is surely in the interests of the Mongolian people but also Mongolian as well as foreign investors. Ministers know that the proof of the pudding is in the eating though and have also set up a special unit within the Cabinet office to speak directly with international investors who have been the victims of fraud and money laundering. There are a number of well documented cases of wrongdoing which thanks to Mongolia's free press have received some attention within the country itself. The issue of the Zasag Chandmani Mine is one that also needs to be resolved. British investors are owed $50m+, which they have been trying to recover for a long time, whilst the Mongolian owner of the project has evaded arrest and fled the country. Such stories detract from the incredible success of Mongolia's entrepreneurs in establishing a thriving private sector in just thirty years with many dynamic companies boasting both substantial growth and impeccable business practices.
Mongolia also needs to put behind it the jibe of 'Hotel Mongolia 'which is a reference to a number of foreign investors who in dispute with powerful business interests have found themselves put behind bars. It would be a gesture of strength and goodwill for example if the British Australian businessman Mo Munshi who is in poor health could be released having completed half of his seven-year sentence.
Mongolia has the potential to be a great democratic success story and deserves the full support of the international community. The amazing success in combating the Coronavirus is the world's underreported story of 2020. The imminent opening of a new international airport and a new rail line into China will strengthen the country's infrastructure. Coking coal transported from the Gobi area into the Chinese market will now have a significant price advantage over Australian exports. The price of copper essential to the development of green energy is rising which is good news for the flagship mine at Oyu Tolgoi operated by Rio Tinto. The project could alone account for nearly a third of national output by 2027. When I visited the mine as the plane took off in a snowstorm from Ulaanbaatar I got chatting to the passenger sitting next to me. He was an engineer of about 30 who had been brought up in the Ger district at the edge of the capital and had won a scholarship. Now he had a well paid position of real responsibility at Oyu Tolgoi and had a family of his own. That has to be a success story for all involved.
Furthermore, with gold priced at over $2,000 per ounce, Mongolia should prioritise policies and initiatives which stimulate the sustainability of this sector so that the country's gold reserves held by international banks for safe-keeping can stand tests of probity and help to strengthen the legitimate wealth of the nation which can be borrowed against to finance development projects. There are still gold investments made by international investors which remain blocked by the inconsistent application of policy and regulation. There is also the real social issue concerning the welfare of up to 100000 artisanal gold miners which must be addressed by all involved in the industry. As elsewhere economic conditions are currently tough, but most analysts predict significant growth in 2021. Pride in the nation means that many qualified Mongolians return from study and professional work abroad to make their own contribution to development. The Government was elected on a social democratic platform and there is a healthy debate about the boundaries between state intervention and the market and the best way to combat poverty and expand opportunity. The new Parliament has already held an Investors Roundtable which will help dialogue going forward. The people are weary of corruption and it is worthy of note that no less than four former Mongolian Prime Ministers have recently received jail sentences in relation to this.
The 2020's could be a decade of rising prosperity for Mongolia with a rapid rise in GDP per capita from the current $4500 per head. The imminent decision to remove Mongolia from the grey list will be a real boost. If Mongolia is to become a magnet for much needed foreign investment it is essential that the country fully commits to a new era of transparency and probity. Never again must the nation find itself on the FATF grey list – twice is already two times too many. In return those with capital to invest need to fully respect the traditions and democracy of the land of the blue sky. The second verse of the Mongolian National Anthem perhaps provides a good text for all to work to:
'With all honest nations of the world
Strengthen our bonds
With all our will and strength
Let's develop our beloved Mongolia'
Mongolian British Chamber of Commerce
Mongolia and Coronavirus
Mongolian Election 2016 Update
Commentary on Mongolian Election, 2016
Prime Minister Ch. Saikhanbileg's address to the nation, April 5 2015
First Doing Business with Mongolia seminar of 2015
Retailing in UB, tracking camels in the Gobi, and scenarios for 2040…
From First Ladies to Football Clubs: a sparkling Doing Business with Mongolia seminar
Designed and built by Hughes Design & DJA


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Special Containment Procedures: SCP-422 is to be contained in a 3.5 m x 3.5 m room. The room is to be kept bare, save for SCP-422's bedding, water bowl, and a dog toy provided by Dr. ██████.
SCP-422 is to be fed twice a day, on a strictly carnivorous diet. SCP-422 may be fed any type of raw meat, provided in portions appropriate for a medium-to-large size dog. All meat must be carefully boned, as consuming bone can cause [DATA EXPUNGED] and other anomalies with SCP-422's hide.
SCP-422 is to be monitored by security cameras placed in its enclosure, as well as two guards armed with tranquilizers stationed at the door. Though the creature has shown no interest in escaping or unprovoked hostility, it has the capability of doing so.
Description: SCP-422 is a large quadruped, 83 centimeters at the shoulder and weighing 53 kg, though size and weight vary minutely from day to day. SCP-422 is constructed entirely out of large pieces of the bodies of other animals, stitched in place with muscle fiber and trace amounts of cartilage. The creature's major organs appear to be composed of portions of other organs, though a given organ will only be made of portions of that type of organ (e.g., its heart is made of connecting chambers of other hearts). It has a flat face with two mismatched eyes- one green cat-like eye and one brown with a horizontal pupil like a goat. Its nose consists of two small slits just below the eyes, and its mouth is abnormally wide, stitched about the corners in such a way that it appears to be grinning. Its back legs are also much longer than its front legs, resembling a frog's legs with an abnormal number of joints.
SCP-422's body lacks stability. No patch or organ will stay the same for an extended period of time, with the shortest shift occurring after six hours and the longest after twenty-five hours. There is no pattern to these changes, though a single patch will not change more than once within an 18-hour period. The patches will occasionally respond to outside stimulus, such as producing heavy fur or thick leathery hides in colder conditions.
SCP-422's brain is constructed in the same fashion as its other organs, leading to the development of odd traits as different portions of its brain shift and change. Possibly due to the original construction, many characteristics remain consistent throughout shifts, including:
• Poor motor control
• Very poor short- and long-term memory, often unable to remember events from several weeks ago or even several minutes ago.
• Frequent deafness in one or both ears
• Numbness and lack of sensation in the extremities, including unnatural tolerance to pain
• Lack of facial recognition- will not recognize itself in a mirror or photograph and may even show fear of its own reflection.
• Colorblindness, though this diminishes as intelligence increases
Additionally, SCP-422's intelligence can range anywhere from that of an average house cat to a seven-year-old child, with the average being that of a five- or six-year old. Dr. ██████ has been keeping extensive records of daily fluctuations in SCP-422's intelligence, physical traits, and patch count. More information on Dr. ██████'s studies can be found at [DATA EXPUNGED].
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Another Stage of History
A Character Creation and Edit Officer Site
Intro to Creative Writing
Professor Gabriel
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redpajama_set_name: RedPajamaCommonCrawl


From the buckwheat fields of Northern Maine.
I like honey in my tea and find I can use only a quarter or third of a teaspoon when I use the raw buckwheat honey as it has such a nice rich flavor. Typically I would use a whole teaspoon of most other types of honey. As a borderline diabetic, it's good to be able to use less and still enjoy my tea. I have bought it at Fryeburg Fair numerous times (I live in MA and can't find it here) and have turned others on to it too. One such person is elderly and his taste buds are diminished and he loves this as he can taste it easily (We always buy him some when we are at the fair). I really love it.
Q: I absolutely love your label with the bear with the veil on. I'm a quilter and would love to use this as a pattern for my own personal use. Can/do I have your permission to use it as a pattern? Don't worry, I have no plans on selling it, just think it's super cute. Please reply. Have a great day!
A: You have our permission! We have no problem with you using it as long as it's just for personal use and not for profit.


Calling a qualified independent engineers and architects insurance company is a vital step if you're an architect that's searching for top protection for your firm. You want to be certain that you're protected from lawsuits that may be potentially disastrous to your firm along with your career. It doesn't matter how perfectly a design may be executed. Many smaller companies can go under as a result of even one frivolous lawsuit. Having insurance in place making sure this isn't going to happen is essential if you care about the future of your business. This is true whether you're just starting out or have been in the industry for years. This is why you owe it to yourself to contact Fenner & Esler when you need an independent engineer insurance company.
We provide service to engineers all over the country as a top engineers and architect insurance company. We have many years of expertise in the industry and in that time have worked with a broad range of types of professionals. As a matter of fact, we've been doing business since 1923. In that time we have assisted countless clients in ensuring that their firm has the maximum protection possible. A unique insight into the requirements design professionals is the result of this experience, and something which makes it worth your while to work with us. Our highest priority is meeting your firm's precise requirements as cost-effectively as possible. For highly flexible insurance from a leading engineer insurance brokerage, call us today and learn what we can do for you.
When you require architect & engineers insurance coverage, there are various reasons why it's in your best interest to go with Fenner & Esler. The fact that we are an independent brokerage is a significant factor, offering you many advantages. The flexibility this provides us makes locating insurance options which will fulfill your precise needs simple. Different firms have different needs, from small start ups to larger firms which have existed for years. This makes locating insurance with options that will be ideal for your own company and its requirements absolutely essential. Our insurance choices are scalable to your requirements. This means should you take on more clients, or require special coverage for larger projects, it can be adjusted appropriately. When it comes to bigger brokerages, you will find this is a service they don't offer, and will instead try to fit you into plan that is one size fits all. Your best interests will never be served by these types of plans. They generally leave you with the choice of needing to pay extra for services which you aren't going to need, or leave you without services you will. Instead, as an independent engineer insurance broker we'll take your needs into consideration and provide precisely what you're looking for.
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We make an effort to meet all your requirements as easily as possible as a top independent engineer insurance company. It's always free when you contact us at Fenner & Esler to get a quote. Our number one priority is ensuring your needs are taken care of. It doesn't matter if you're already in the middle of a multiyear insurance policy. We will still provide you with a quote for the coverage that you require. We can also provide services as an independent environmental consultant and surveyor insurance company. Application is simple and whatever questions you may have we're here to answer them. When you are in need of an independent engineers insurance company, make your first choice Fenner & Esler.


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GameTribute
EA Sets New Guinness World Record For Most Downvoted Reddit Comment
GameTribute Staff
Records are usually to be admired, but definitely not this one.
Electronic Arts has won what has to be one of the worst Guinness World Record of the digital age.
The American game publisher has received the 2020 Guinness World Record for the most downvoted Reddit comment as a result of its controversial comment on Star Wars Battlefront 2's lootboxes back in November 12, 2017. This dubious yet impressive feat was spotted in the Guinness World Records by Reddit user -amsha-.
EA's unpopular comment received an almost unbelievable 667,821 downvotes, handily beating the second most downvoted comment by more than 600,000 votes. Oddly enough, it also received 109 Reddit Gold awards.
Here is the comment in full:
The intent is to provide players with a sense of pride and accomplishment for unlocking different heroes.
As for cost, we selected initial values based upon data from the Open Beta and other adjustments made to milestone rewards before launch. Among other things, we're looking at average per-player credit earn rates on a daily basis, and we'll be making constant adjustments to ensure that players have challenges that are compelling, rewarding, and of course attainable via gameplay.
We appreciate the candid feedback, and the passion the community has put forth around the current topics here on Reddit, our forums and across numerous social media outlets.
Our team will continue to make changes and monitor community feedback and update everyone as soon and as often as we can.
EA's comment is hated on a scale never before seen in Reddit history, and we don't think it will be beat in the foreseeable future.
Simply creating a free account on the Guinness World Records website will allow you to look up every record to date, including the EA record, which is listed under "Most downvoted comment on Reddit."
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Mass Effect: Andromeda Releases in March 2017
Anti-violent Games Politician Leland Yee Sentenced to Prison
Leland Yee, a former California State Senator and gun control advocate who tried to pass a bill banning the sale of violent games to children, has been sentenced to five years in prison for racketeering, weapons smuggling, and other criminal acts.
According to San Jose Mercury News, 67-year-old Yee and 25 other defendants were arrested during an FBI sweep in March 2014. He faced up to 20 years and a $250,000 fine plus restitution, but a plea deal reduced the sentence.
Prosecutors said he demonstrated "a venal attitude toward his position as an elected public official" and had absolutely no qualms abusing his position of power. In other words, he is a shameless hypocrite.
Other defendants include dRaymond "Shrimp Boy" Chow, the current Dragonhead (leader) of the San Francisco-based Chee Kung Tong organization and Yee's consultant, Keith, who was charged with "soliciting donations from FBI undercover agents, in exchange for multiple official acts."
Yee has a criminal history. He was arrested in 2000 after being suspected of shoplifting suntan oil and, in 1999, was pulled over twice by police for suspicious of looking to hook up with a prostitute. He was never charged for the latter.
The world is full of hypocrites, people, and Yee is a perfect example of one. Beware…
Angry Dad Destroys Son's Xbox After Catching Him Stealing
While many kids get away with stealing, one American kid not only got caught in the act, but also had to watch as his Xbox got destroyed by his father as punishment.
The mischievous kid was actually 'fortunate' to be given two options by his pissed off dad: 1) get the ass-whopping of a lifetime, one with a belt, or 2) watch as his $400 Xbox 360 gets obliterated.
Needless to say, he ended up seeing — watery eye and all — what happens when a full-size SUV runs over a fragile gaming device and his days owning noobs in Call of Duty come to an end. Daddy didn't want to go jail…
Is there any kid who wouldn't be traumatized by something like that?
Which option would you have chosen?
Check Out the Official Assassin's Creed Movie Poster
The Assassin's Creed movie has received its first official poster and it's what you likely expected.
Similar in presentation as the first Assassin's Creed game, the poster features the now-familiar Animus' virtual glitching lines and a soaring eagle, both major symbols of the franchise.
The Assassin's Creed movie releases on December 21, 2016, and stars Michael Fassbender and Marion Cotillard. It is directed by Justin Kurzel, who worked with both actor's on the critically-acclaimed 2015 iteration of Macbeth.
Details about the movie's plot are scarce. Some reports claim Fassbender would play Desmond Miles, but it is currently unknown if any of the video game assassins will be featured.
Check out the Assassin's Creed movie poster and let us know what you think. Are you as excited as we are to finally see Assassin's Creed on the big screen?
Guy Plays Arcade Shooting Game as if it's Real Life
The goal of every video game developer should be to make games that immerse players completely. If you're like me, lack of immersion ruins the gameplay experience; however, if you're like the Asian guy in this video, it's only the beginning of something truly intense.
While playing an arcade shooting game, he completely acts out the in-game character, entering the exact same gun-holding pose, walking and running to get to places, and falling to the floor when shot. And, yes, those are shooting gloves he is wearing!
He gives a new meaning to video game immersion…
You could laugh at him all you want, but he's having a blast and likely got way more out of his 0.50-$1 than we will ever. He's intense and doesn't care what anyone thinks…
Chinese Parents Sell Children to Buy Video Games
In what must be one of the dumbest, careless and most rotten things anyone can do, two Chinese parents have been arrested for allegedly selling their children to child traffickers in order to buy more virtual items for free-to-play video games.
According to the young unwed parents, their first child was unplanned and, as they were not able to support him financially, was sold off to traffickers. It didn't help that they were blowing whatever little money they had on online games.
You'd think they've learned a lesson the first time around, but then they had a second son. And again they decided they could support the child, so they sold him off too.
Video game addiction is a problem in China, but child trafficking is an even bigger problem, one affecting thousands of people every year. Children in the possession of traffickers are sold to new parents, street gangs and street peddlers, and/or even orphanages for adoption overseas.
Considering that trafficking children is highly illegal in China, convicted felons often face execution. It was the husband's father — likely out of concern for his grandchildren — who reported the problem to the police. The couple are now in prison and awaiting trial and sentencing.
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SHOP TALK: J.T. Krul on writing team books vs. solo series
By DCE Editorial Friday, November 19th, 2010
Whenever I tell anyone that I am a comic book writer, I always get the same response: "That's amazing. How do you do it? How do you draw all those pictures?" That's how I know I'm talking to someone who probably hasn't ever picked up a comic book. You can spot the writers just as easily because they'll quickly go from plot points to the craft of writing comics. One that's come up quite a bit is: How do I approach writing a solo book like Green Arrow, as opposed to a team book like Teen Titans? Let's put aside the tonal differences, which are plain to see - Green Arrow is a much darker book than Teen Titans - and focus on the structural differences. With a solo book, the overall focus is naturally the one character. That's not to say Green Arrow exists in a vacuum (although one might argue the isolating nature of the forest in Star City is a bit of a vacuum…but I digress). For the most part, the story unfolds primarily through Green Arrow - as he experiences it. Obviously, he interacts with various people, be they allies or enemies or both, during his stories - but I am placing an emphasis on his viewpoint - filtering most of what we see through him. Look at Green Arrow #2 - This issue highlights that personal perspective throughout. The book opens with an image of the strange new character called Galahad, wandering through the forest, but the narration is Ollie - talking about the hazy nature of the forest. Having this figure pop up in the forest is a true mystery, but the key may boil down to how his presence affects Green Arrow. Later, as Green Arrow and Green Lantern fight the Royal Guard Soldiers in the forest, we hear Ollie's commentary about the fight and about Green Lantern. And although it's a team effort, the focus is clearly on Green Arrow's actions (and not merely because Green Lantern's ring is made powerless inside the forest. For me, another aspect of a solo book showcased in Issue #2 is the importance in keeping your hero highly visible within the story. Green Arrow is only absent from four pages in the entire issue: those opening two pages with Galahad I mentioned (but since we are hearing Ollie's words that doesn't really count); the one page scene with the Queen as she watches her goons heading off to hunt after the Emerald Archer; and finally the one page where Green Lantern gets his juice back and neutralizes the helicopters circling above the forest. Beyond that, it's all Green Arrow all the time. Surely, the time comes to highlight other aspects, but it's important to be mindful that a big part of a solo book is seeing how our protagonist reacts and responds to events around him - sometimes even outshining the events themselves. Case in point - Moving forward in Green Arrow as the epic conclusion to Brightest Day approaches, more visitors will be finding there way to the forest - but the focus will remain on Green Arrow. How the events of Brightest Day will affect him and how he will react to them. On the flip side, in a team book such as Teen Titans, the focus exists on a giant wheel, constantly spinning - constantly shifting from one character to the next. The amount of narration and head time is reduced because a team book unearths more about character through interpersonal relationships, as each titan shifts from central role to supporting role and back again. I'll use Ravager as an example because in some ways her personality is similar to Green Arrow. In Issue #88, I use narration a bit - delving into her feelings about her father and the possibility that her mother (long thought dead) might still be alive. It's a very private matter - not something Ravager would easily share with even those closest to her (hence the narration). But in terms of her character and the dynamic with the team, it comes out in direct conversation - such as the exchange between Ravager and Wonder Girl in the aftermath of the battle with the Feral Boys. With that short exchange, we can tell that Ravager doesn't really like following anyone's orders and thinks Wonder Girl is too timid. Wonder Girl may have a problem with bloodshed, but Ravager doesn't. For her, the ends justify the means - "We won." But this scene isn't really about Ravager, as much as it's about Wonder Girl - which carries over into Wonder Girl's discussion with Beast Boy. Ravager may be involved in the topic, but the focus in on Wonder Girl and her view of what the team needs to be. Even the fact that she is having the conversation with Beast Boy is important, given their recent clashing over the role of leader. Obviously with Robin coming on board, he'll take a bit of the focus as the new kid on the block, but he'll quickly have some competition in that department. The second main arc will bring the newest titan - Solstice - into the fold, thus giving her a chance to shine (yes, the reference to her powers is blatant). And much of her story with Teen Titans will be how certain members react to her - particularly Beast Boy and Raven (again - interpersonal relationships). Looking back at what I've written, it sounds as though the differences are monumental - seismic shifts when writing - but really they are shades of gray. It all boils down to wrapping your heads around the characters, place an obstacle in their way (the bigger and the badder the better), and see how it all unfolds - see how the drama reveal their character. And I can promise you the obstacles to come are going to be just that - BIGGER and BADDER! j.t. krul
Editor Wil Moss teases T.H.U.N.D.E.R. AGENTS #2
diogenes neves, green arrow, j.t. krul, nicola scott, ravager, teen titans


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Media / Press Releases
Senator Rand Paul shamefully blocks Iron Dome funding for 100 days
Washington, D.C. (January 11, 2022) — Wednesday marks the 100th day that Republican Senator Rand Paul has blocked vital supplemental funding to replenish Israel's Iron Dome defensive missile batteries, depleted in May when the terrorist group Hamas launched over 4,500 rockets at Israeli civilians.
"As we reach the 100th day of Senator Paul blocking Iron Dome funding, we continue to be appalled by his complete disregard for Israel's security and its ability to readily defend itself against rockets launched by Hamas terrorists," said Democratic Majority for Israel President Mark Mellman. "For the good of the U.S.-Israel relationship, and for the safety of all Israelis — Jewish and Arab alike — Republicans must hold Senator Paul accountable and work to pass this critical funding."
Last year, on September 23rd, the House of Representatives — including 95% of House Democrats — passed critically needed Iron Dome funding on a bipartisan basis. On October 4th, Senate Foreign Relations Committee Chairman Bob Menendez (D-NJ) asked for unanimous consent to fast-track the bill in the Senate — Senator Paul objected, thereby denying America's closest Middle East ally this critical funding to protect civilians from terrorist attacks. Nearly three months later, the funding remains in limbo.
Senator Paul can add Iron Dome funding to a long list of common sense, bipartisan bills he's blocked or obstructed, including but not limited to, the Emmett Till Antilynching Act, which would make lynching a federal hate crime; the Permanent Authorization of the September 11th Victim Compensation Fund Act, which would ensure the 9/11 Victims Fund remains solvent through 2092; and Daniel's Law, which would bar data brokers from selling the identifying information of federal judges.
Shortly after Sen. Paul began blocking Iron Dome funding, Democratic Majority for Israel mobilized grassroots supporters to demand that Senator Paul and his Republican colleagues allow the bill to come to the floor, including hundreds of letters sent to Senator Paul's office and a daily social media campaign.


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Viking Film is the Amsterdam based film production company founded in 2011 by Marleen Slot. International in scope, Viking Film wants to make high-quality films for both Dutch and international audiences with a special focus on arthouse and animation films. Viking Film wants to be cross-border and intends to enter into cooperation with producers and makers from Europe, Latin America and Asia.
Viking Film finished the feature films DIRTY GOD (Sacha Polak, Sundance Competition 2019), ROJO (Benjamin Naishtat, TIFF Platform), OSCURO ANIMAL (Felipe Guerrero, IFFR Tiger Competition 2016), SIV SLEEPS ASTRAY (Catti Edfeldt, Lena Hanno Clyne opening film Berlinale Generation K+), NEON BULL (Gabriel Mascaro, selection Venice Orizzonti and TIFF Competition 2015), ZURICH (Sacha Polak, Berlinale Forum winner CICAE Art Cinema Award 2015), THE SUMMER OF SANGAILE (Alanté Kavaïté, selected for Sundance Competition and Berlinale Panorama 2015), feature documentary NEW BOOBS (Sacha Polak) and the co-production LEONES (Jazmin Lopez, selected for Venice Film Festival 2012). Besides that she's working on feature film OINK'S REVENGE by Mascha Halberstad.
Marleen worked as a producer at Lemming Film for many years. Her productions at Lemming Film include the feature films TONY 10 (Mischa Kamp), TAKING CHANCES (Nicole van Kilsdonk, opening film Cinekid 2011, selection Berlinale K+ 2012), SNACKBAR (selection Berlinale 14+, 2012), MY JOY (Sergei Loznitsa, Competition Cannes Film Festival 2010), OXYGEN (Hans van Nuffelen, European Film Academy Discovery Award) and VIVAN LAS ANTIPODAS! (Victor Kossakovsky, opening film Venice Film Festival 2012).
Marleen studied Communication Science at the University of Amsterdam and specialised in Media Entertainment. In 2007 she attended the EAVE producer's training and in 2009 she participated in ACE, the workshop and network for European producers. Besides this, she was president of the NFTVM (Association of New Film and Television Makers) from 2008 until 2010 and presently she is chairman of the Film Producers Netherlands association and in the board of RIALTO cinema. In 2013 she was selected Producer on the Move during the Cannes Film Festival.
Marleen Slot


Die Vorgeschichte zu Dragon Age: Origins, verfasst von Dragon Age Lead Writer David Gaider.
Invitingly designed, illustrated with hundreds of pieces of lush art from the creators of the games, this is the definitive guide to BioWare's dark fantasy masterpiece! For Dragon Age newcomers, this comprehensive volume brings you up to speed on everything you need to know about the regions, religions, monsters, magic, and more! For dedicated fans, never before have the secrets of BioWare's epic fantasy been revealed so completely and so compellingly! This dramatic, accessible, beautiful tome illuminates the darkest corners of the Deep Roads to the most illusory reaches of the Fade, taking readers on a journey through one of the most fully realized fantasy universes of our time!
Written by and starring Felicia Day, Dragon Age: Redemption is a six-part series based on Bioware's Dragon Age video game franchise.
Die Zerstörung des Zirkels der Magie in Kirkwall hat bei den Magier und Templern in ganz Thedas für großes Chaos gesorgt. Einige Magier wollen sich gegen ihre Bewacher, die Templer, erheben, während andere sich dafür einsetzen, inmitten der Wirren, Ordnung und Stabilität zu bewahren. Im majestätischen Weißen Turm in Val Royeaux, dem Machtzentrum der Templer, erreichen die Anspannungen ihren Höhepunkt. Die Taten einiger Radikaler haben die Aufmerksamkeit der Sucher auf sich gezogen, einer mächtigen, geheimen Abteilung der Templer, die nun koste es was es wolle das Kommando übernehmen und die Ordnung wiederherstellen will. Was die Lage noch verschlimmert: Ein geheimnisvoller Mörder sucht die Hallen des Weißen Turms heim, unsichtbar für alle, bis auf einen einzigen Magier. Da Rhys als Einziger den Mörder sehen kann, rückt er als Hauptverdächtiger ins Zentrum der Ermittlungen. Rhys glaubt nicht, dass er seine Unschuld beweisen kann: Seine Zukunft erscheint ihm daher kurz und trostlos. Doch dank seiner magischen Fähigkeiten erhält er eine Schonfrist: Er muss an einer Expedition teilnehmen, die tief ins westliche Ödland von Orlais führt. Dort verbindet sich sein Schicksal mit dem einer wunderschönen Templerin, dem einer gequälten Seele, und mit dem von Wynne, der Heldin der Verderbnis. Zusammen decken sie ein Geheimnis auf, das viel bedeutender ist, als sie es sich hätten vorstellen können. Ein Geheimnis, das das Schicksal der Magier in ganz Thedas für immer verändern wird.
Das fantastische mittelalterliche Reich Ferelden wird regiert von einem Ritterorden der Magier unter Führung einer weisen Magierkönigin. Davon abgespalten haben sich vor langer Zeit sogenannte Blutmagier, weshalb ein ständiger Bürgerkrieg schwelt und die auch die noblen Magier einander nicht mehr überall über den Weg trauen. Nun hat ein Blutmagier namens Fenic dem Reich den Krieg erklärt, und es ist an der Spezialagentin Cassandra, dessen Pläne zu durchkreuzen und seine Verbündeten im Orden zu enttarnen.
Erlebe den epischen Nachfolger des Spiels des Jahres 2009 von den gefeierten Schöpfern von Dragon Age: Origins und Mass Effect 2. Du bist Hawke, einer der wenigen, die der Zerstörung deiner Heimat entfliehen konnten.
Journey into the darkest and deadliest part of Orlais, where the weight of titles matters less than the strength of blades. Empress Celene of Orlais rose to the throne of the most powerful nation in Thedas through wisdom, wit, and ruthless manipulation.
Fantasy roleplaying goes back to its dark and gritty roots with the Dragon Age RPG, the latest game from the company that brought you A Song of Ice and Fire Roleplaying and Mutants & Masterminds. Based on the smash hit Dragon Age: Origins computer game, the Dragon Age RPG brings the excitement of BioWare's rich fantasy world to the tabletop. Make your own heroes and control your own destiny in the lands of Ferelden and beyond.
The lead writer of BioWare's hit Dragon Age games concludes King Alistair's epic quest - in a journey beyond reality itself! Fans around the world have recognized the Dragon Age comics to be an integral addition to the videogame saga. Now, series writer David Gaider pits King Alistair and his noble companions Varric and Isabela against their most nefarious foe - the twisted blood mage Aurelian Titus! Don't miss what critics are calling "wonderful, exciting examples of the fantasy genre in comic book form!"
Available in print for the first time, "Dragon Age: The Silent Grove" is the perfect introduction to BioWare's dark fantasy universe! In this essential, canonical story from David Gaider, lead writer of the games, King Alistair, accompanied only by rogues Isabela and Varric, embarks on a quest deep inside the borders of Antiva - a nation of assassins! Together, they will encounter a prison break, dragons, the mysterious Witch of the Wilds, and one of the greatest secrets in the history of the world!
Tells the story of reluctant monarch King Alistair who travels to an empire of evil mages. Accompanied by the pirate captain Isabela and the underworld merchant Varric, Alistair will stop at nothing to uncover the fate of his lost father - even if it means battling an army of cultists singlehandedly.
Helping set the stage for BioWare's hotly anticipated Dragon Age: Inquisition, this deluxe oversized hardcover collects every Dark Horse Dragon Age comic to date--The Silent Grove, Those Who Speak, and Until We Sleep— an epic trilogy complete in one volume, written by Dragon Age lead writer David Gaider! This edition also features extensive annotations from the creators of the comics as well as a section of never-before-seen related material.


text:
2017 MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS _ MERS, MERS CoV
2017 • 11 Pages • 306.31 KB • English
+ COVID-19 + coronavirus
Posted December 22, 2020 • Submitted by Superman
Summary of 2017 MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS _ MERS, MERS CoV
[56] Martin JE, Louder MK, Holman LA, Gordon IJ, Enama ME, Larkin BD, et al. A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a Phase I clinical trial. Vaccine. 2008;26:6338–6343. [57] McFee RB. Viral Hemorrhagic Fever Viruses in Novel viruses, emerging pathogens – The pandemic threat continues. Dis a Month. 2013;59(12)405–448. [58] Schmitz J, Roehrig J, Barrett A, Hombach J. Next generation dengue vaccines: a review of candidates in preclinical development. Vaccine. 2011;29(42) 7276–7284. [59] Hunsperger EA, Yoksan S, Buchy P, et al. Evaluation of commercially available anti-Dengue virus immunoglobulin M tests. Emerg Infect Dis. 2009;15 (30)436–440. [60] Sabchareon A, Wallace D, Sirivicayakul C, et al. Protective efficacy of the recombinant, live attenuated, CY tetravalent dengue vaccine in Thai schoolchildren: a random controlled phase 2b trial. Lancet. 2012;380(9853)1559–1567. [61] Noisakran S, Onlamoo NN, Songprakhon P, Hsiao HM, et al. Cells in dengue virus infection in vivo. Adva Virol. 2010 (ID 164878). [62] van den Worm SHE, Eriksson KK, Zevenhoven JC, Weber F, et al. Reverse genetics of SARS related coronavirus using vaccinia virus based recombination Published: March 7, 2012. http://dx.doi.org/10.1371/journal.pone.0032857http:/journals.plos.org/plosone/article?id=10.1371/journal.pone.0032857% 20Last%20accessed%2003/12/17. MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS – MERS, MERS CoV Fig. 10 MERS CoV [1]. The National Institute of Allergy and Infectious Diseases (NIAID), this highly-magnified, digitally- colorized transmission electron microscopic (TEM) image reveals ultrastructural details exhibited by a single, spherical- shaped Middle East Respiratory Syndrome Coronavirus (MERS-CoV) virion. BACKGROUND In June 2012 a new CoV (Figure 10) [1] was isolated from a patient who died from severe pneumonia and multi-organ failure in Saudi Arabia [2,3]. This newly identified respiratory viral illness was caused by a novel coronavirus, which was initially designated as human betacoronavirus [2–5], but was eventually named Middle East Respiratory Syndrome Cor- onavirus (MERS CoV). Reminiscent of, and worth considering as a caution for greater vigilance towards emerging pathogens, the suddenness that SARS CoV emerged as a new cause of severe pulmonary illness, has been replicated in this new aggressive respiratory illness MERS CoV. Unlike SARS CoV, it has not caused the thousands of cases over a short period of time. But it also differs from SARS CoV in that it carries a much higher case fatality rate, and causes more severe illness [6,7]. According to the World Health Organization (WHO) as of 12/05/16 there have been 1917 laboratory confirmed cases of MERS CoV since 09/12, reported from 27 countries (Maps 1 and 2), resulting in 677 deaths, yielding a significant case fatality rate (�35%) [6]; a fatality rate for a coronavirus that is significantly greater than that associated with SARS CoV Delta (�9%), at least among confirmed cases [6–8]. As with other CoV, including SARS CoV, the exact epidemiology, including whether there are larger numbers of mild illness, remains unknown. Males over 60 yrs of age seem to be at higher risk of severe disease symptoms and death among those infected. While the greatest spike in cases occurred near 2014, new cases continue to be reported. To date, since September 2012 there have been cases reported in 27 countries across 4 continents, with most human cases occurring in Saudi Arabia (Map 1 and 2) [6]. R.B. McFee / Disease-a-Month 63 (2017) 240–278 262 Map 1 http://www.who.int/emergencies/mers-cov/map-7-july-2016.png Last accessed 02/05/17. Map 2 http://cdn1.vox-cdn.com/assets/4499449/Screen_Shot_2014-05-23_at_10.42.47_AM.png. MERS CoV belongs to lineage C of betacoronaviruses. It is an enveloped, single stranded, positive sense RNA virus. Structural proteins include spike (S), envelope (E), nucleocapsid (N, and membrane (M) protein [9]. MERS CoV attaches to R.B. McFee / Disease-a-Month 63 (2017) 240–278 263 the host cell functional receptor human dipeptidyl peptidase 4 (hDDP4). The most immunogenic of the four structural proteins is the S protein, which is the virus' only surface glycoprotein – it mediates viral attachment and fusion via the hDDP4. Since this receptor is widely found in endothelial and subendothelial tissues in lungs, the gastrointestinal tract (GIT), and kidneys, this may at least in part explain the associated multisystem organ failure associated with severe cases. Of note for health care providers, according to information from a June 2016 outbreak in Riyadh, Saudi Arabia, 24 contacts tested positive for MERS CoV from an index case who presented in critical condition to the hospital where it was confirmed as another case [10]. Of the 24, there were 20 healthcare workers that came into contact with the patient. Human to human transmission is well documented, mostly nosocomial outbreaks, but propagated transmission seems to be limited. Healthcare associated clusters of MERS CoV are associated with most reported cases [10–12]. The estimated Ro or re- productive rate is estimated at 0.7 [7,13,14], although in health care settings it is estimated at 41; still low when compared with measles, a highly contagious viral illness with Ro 12 – 18 [15]. That notwithstanding, the risk of human to human transmission for MERS CoV or other infections cannot be understated. Not surprisingly, diagnosis has been delayed in certain regions that suffer from overcrowding and poor infection control measures. MERS CoV is still considered a risk for epidemics in Saudi Arabia. MERS CoV is a zoonotic virus that has entered the human population through contact with infected dromedary camels in the Arabian Peninsula. Camel to human transmission is known [16–22]. Research suggests MERS CoV originated in bats before camels which may be the intermediate host. Closely related CoV have been found in bats from other regions [23,24]. For example, a novel CoV found in a vesper bat from South Africa is very similar to MERS CoV, differing by only one amino acid. Studies suggest dromedary camels are the primary source for human infection. Nearly 67% of human cases are male, and the median age among reported cases is 52 [7]. The majority of cases are of Middle East origin, even though cases have been reported from outside the region, where they likely are seeking care, or are returning from travels. A CoV similar to the MERS CoV cases has been found in Camels from Egypt, Oman, Qatar, and Saudi Arabia. Direct contact with saliva of infected camels, or consuming milk or meat from same are considered a risk factor. One study noted the seroprevalence of MERS CoV is several times higher in people with regular exposure to camels compared with the general population [17–19] although there are cases w/out contact with sick animals or products derived from them. CLINICAL MERS CoV can cause a spectrum of illness ranging from mild upper respiratory symptoms to rapidly progressive lower respiratory infection/pneumonia [1–8,16,25–30]. Fever, cough, and breathing difficulties accompany pneumonia that can progress to acute respiratory distress syndrome (ARDS), multi-system organ failure, and death [25–31]. Many patients present with non-pulmonary symptoms such as headache, myalgia, vomiting, and diarrhea. MERS CoV progresses more rapidly to pulmonary failure, as well as acute kidney injury (AKI) than SARS CoV. Patients with underlying comorbidities are associated with more advanced, complicated disease and death, than essentially healthy patients. MERS CoV rapidly triggers cellular damage, and induces a proinflammatory response in cells [25]. The most common signs and symptoms associated with MERS CoV at presentation are fever, cough, and shortness of breath. Typically presenting symptoms include fever, cough, chills, dyspnea, myalgia, abdominal pain, nausea, vomiting, and diarrhea. Laboratory abnormalities associated with MERS CoV include thrombocytopenia, lymphopenia, leukopenia, ele- vated serum lactate dehydrogenase (LDH), elevated aspartate aminotransferase (AST), elevated alanine aminotransferase (ALT), along with abnormal renal function tests [5,29,30]. Superinfection from viral or bacterial causes has been found in some patients and may complicate the course of the disease. Severe cases of MERS may require intensive care and me- chanical ventilation, with a relatively large number of patients progressing to respiratory or renal failure. A retrospective radiology review of CT findings in laboratory confirmed cases of MERS CoV noted that cough, fever, and Dyspnea were the most common presenting symptoms. Three of the seven subjects died [31]. The high case fatality rate associated with MERS CoV has sparked interest in the role of virus on the immune system. One area of interest is the potential for cytokine storm. Some studies have shown MERS CoV is associated with an attenuated interferon (IFN) response, and does not induce inflammatory cytokines [7,32,33]. However a study by Lau demonstrated delayed Proinflammatory cytokine induction by MERS CoV in Calu 3 cells, while there was a lack of production of antiviral cytokines TNF alpha, IFN beta, and IP 10 (5). TNF alpha is noted as an important acute phase pyrogen that inhibits viral replication. IFN beta can induce antiviral response via upregulation of host factors. By attenuating TNF alpha and IFN beta MERS CoV in comparison to SARS CoV may more readily evade innate antiviral host immunity. The possibility that MERS CoV attenuates innate immunity while inducing an inflammatory response in human lung epithelial cells also exists. A macaque model for MERS CoV revealed the virus caused localized to widespread pneumonia in all infection animals. MERS CoV was noted by Lau et al to increase IL 8. In RSV, higher levels of IL 8 seems to correlate with increased disease severity. According to the CDC and WHO data, the median incubation period for secondary cases associated with limited human- to-human transmission is approximately 5 days (range 2-14 days) [6,8]. Of note, in MERS-CoV patients, the median time from illness onset to hospitalization is approximately 4 days. In critically ill patients, the median time from onset to in- tensive care unit (ICU) admission is approximately 5 days, and median time from onset to death is approximately 12 days. In R.B. McFee / Disease-a-Month 63 (2017) 240–278 264 one series of 12 ICU patients, the median duration of mechanical ventilation was 16 days, and median ICU length of stay was 30 days, with 58% mortality at 90 days. Chest X-rays should be obtained early in the course of progressive pulmonary illness, albeit CT will provide more in- formation (Figure 11) [31]. Radiographic findings may include unilateral or bilateral patchy densities or opacities, interstitial infiltrates, consolidation, and pleural effusions. Rapid progression to acute respiratory failure, acute respiratory distress syndrome (ARDS), refractory hypoxemia, and extrapulmonary complications (acute kidney injury requiring renal replace- ment therapy, hypotension requiring vasopressors, hepatic inflammation, septic shock) has been reported. CLINICAL TESTING Key to appropriate testing is a thorough history and physical. It is important to consider multisystem function as well as pulmonary status in patients with severe respiratory illness, including suspected MERS CoV, especially those returning from regions where aggressive pathogens are noted. Involving infectious disease and pulmonologist specialists early on, as well as good critical care management are essential. As noted earlier, laboratory findings at admission may include leukopenia, lymphopenia, thrombocytopenia, and ele- vated lactate dehydrogenase levels (LDH). Renal and hepatic function tests, at least for baseline information are worth obtaining. In the Ajlan study [31], all seven patients had lymphopenia. Elevated creatinine developed after admission in all patients. AST also were elevated in all patients. Of note, co-infection with other respiratory viruses and a few cases of co-infection with community-acquired bacteria at admission has been reported in MERS CoV patients. Not surprisingly, nosocomial bacterial and fungal infections have also been reported in mechanically-ventilated patients. According to clinical experience reported to CDC, MERS-CoV virus can be detected with higher viral load and longer duration in the lower respiratory tract compared to the upper respiratory tract, and has been detected in feces, serum, and urine. However, very limited data are available on the duration of respiratory and extrapulmonary MERS-CoV shedding Radiographic Studies According to the Aljan radiology study [31], Chest XRay findings were most notable for airspace and interstitial opacities with MERS CoV. Radiographic findings such as airspace opacities are nonspecific, whereas the interstitial changes were described as reticular or reticulonodular. Total lung opacification and thickening of the bronchovascular markings have been reported as well. Previous chest CT findings with MERS have been reported as bilateral patchy or extensive opacities [5]. Not unexpected, imaging that had features consistent with acute respiratory distress syndrome were typically identified in sicker patients. In Aljan [31] MERS CoV the most common findings on CT (Figure 11) were shows that airspace opacities on CT are common in patients hospitalized with MERS-CoV infection. Airspace opacities are suggestive of an organizing pneumonia pattern. It was also described in H1N1 influenza A viral infections. In most of our patients, ground-glass opa- cities were more extensive than consolidation. Septal thickening and pleural effusions also were demonstrated. Importantly, tree-in-bud pattern, cavitation, and lymph node enlargement were not seen in our cohort. Fig. 11 Lung CT MERS CoV [31]. 27-year-old man with Middle East respiratory syndrome Patient was a smoker who was healthy otherwise. CT was performed 8 days after admission, and 20 days after onset of symptoms. Patient was eventually discharged. Lower lung CT image show large right lower lobe and small focal left lower lobe subpleural consolidations. Chest XRays and CT Scanning (Figure 11) are recommended depending upon the presentation, and clinical course. In the Aljan study [31] the most common CT finding in hospitalized patients with MERS – CoV infection reveals predominantly R.B. McFee / Disease-a-Month 63 (2017) 240–278 265 subpleural and basilar airspace changes, with more ground glass opacities than consolidation. It is important to note this is a small study. Nevertheless this pattern is consistent with organizing pneumonia. Patients recently returning from the Middle East, presenting with significant respiratory illness, with CT findings of peribronchial region abnormalities, organizing pneumonia, should be considered for MERS CoV infection, and if possible, queried about international travel and occupa- tional exposures. LABORATORY TESTING/CASE DEFINITIONS [8,34,35] Case Definitions The CDC provides case definitions. The reader is requested to review periodically this site for updates as the MERS CoV situation can change [8,34]. Although emergency testing can be possible for suspected asymptomatic cases, the CDC guidelines for sending samples for laboratory confirmation are predicated upon a combination of clinical and epidemio- logical factors to identify Persons Under Investigation (PUI) – Table 1. The other two categories per CDC are: Confirmed Case A confirmed case is a person with laboratory confirmation of MERS-CoV infection. Confirmatory laboratory testing re- quires a positive PCR on at least two specific genomic targets or a single positive target with sequencing on a second. Laboratory confirmation of MERS CoV can be obtained by real time polymerase chain reaction (RT PCR) Probable Case A probable case is a PUI with absent or inconclusive laboratory results for MERS-CoV infection who is a close contact3 of a laboratory-confirmed MERS-CoV case. Examples of laboratory results that may be considered inconclusive include a positive test on a single PCR target, a positive test with an assay that has limited performance data available, or a negative test on an inadequate specimen. MERS CoV TESTING NB The reader is advised to check for updated testing procedures with the CDC [35] Interim Guidelines for Collecting, Handling, and Testing Clinical Specimens from Patients Under Investigation (PUIs) for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) – Version 2.1 This is an updated version of the interim guidance document issued by the Centers for Disease Control and Prevention (CDC) January 2014 based on input from public health partners, healthcare providers, professional organizations, and others. CDC will continue to update the document as necessary to incorporate new information that increases our understanding of MERS-CoV. Updates: Minor changes were made to clarify specimen type and collection procedures. 1. Emphasized the recommendation to collect all 3 specimen types (lower respiratory, upper respiratory, and serum) if possible and not just one or two of the three specimen types for testing using the CDC MERS rRT-PCR assay 2. Deleted the recommendation to collect a stool specimen for MERS-CoV testing 3. Provided additional information for collection and processing serum specimens Before collecting and handling specimens for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) testing, de- termine whether the person meets the current definition for a "patient under investigation" (PUI) for MERS-CoV infection prepared by the Centers for Disease Control and Prevention (CDC). See case definitions(https://www.cdc.gov/coronavirus/ mers/case-def.html). Specimen Type and Priority To date, little is known about pathogenic potential and transmission dynamics of MERS-CoV. To increase the likelihood of detecting infection, CDC recommends collecting multiple specimens from different sites at different times after symptom onset, if possible. Points to consider when determining which specimen types to collect from a patient under investigation for MERS include: R.B. McFee / Disease-a-Month 63 (2017) 240–278 266 � The number of days between specimen collection and symptom onset � Symptoms at the time of specimen collection Additional points to consider: � Maintain proper infection control when collecting specimens � Use approved collection methods and equipment when collecting specimens � Handle, store, and ship specimens following appropriate protocols Collection of all three specimen types (not just one or two of the three), lower respiratory, upper respiratory and serum specimens for testing using the CDC MERS rRT-PCR assay is recommended. � Lower respiratory specimens are preferred � Also collecting the following are strongly recommended depending upon the length of time between symptom onset and specimen collection: ○ Nasopharyngeal and oropharyngeal (NP/OP) specimens ○ Serum, are strongly recommended depending upon the length of time between symptom onset and specimen collection. Of note - Respiratory specimens should be collected as soon as possible after symptoms begin – ideally within 7 days. However, if more than a week has passed since symptom onset and the patient is still symptomatic, respiratory samples should still be collected, especially lower respiratory specimens since respiratory viruses can still be detected by rRT-PCR. For example – If symptom onset for a PUI with respiratory symptoms was less than 14 days ago, a single serum specimen, an NP/OP specimen and lower respiratory specimen should be collected for CDC MERS rRT-PCR testing. 1. if symptom onset for a PUI with an ongoing respiratory tract infection, especially lower, was 14 or more days ago, a single serum specimen for serologic testing in addition to a lower respiratory specimen and an NP/OP specimen are recommended. 2. if symptom onset for a PUI with an ongoing respiratory tract infection, especially lower, was 14 or more days ago, a single serum specimen for serologic testing in addition to a lower respiratory specimen and an NP/OP specimen are recommended. General Guidelines For short periods (r 72 hours), most specimens should be held at 2-8°C rather than frozen. For delays exceeding 72 hours, freeze specimens at -70°C as soon as possible after collection (with exceptions noted below). Label each specimen container with the patient's ID number, specimen type and the date the sample was collected. Respiratory Specimens Lower respiratory tract Broncheoalveolar lavage, tracheal aspirate, pleural fluid. Collect 2-3 mL into a sterile, leak-proof, screw-cap sputum collection cup or sterile dry container. Refrigerate specimen at 2-8°C up to 72 hours; if exceeding 72 hours, freeze at -70°C and ship on dry ice. Sputum. Have the patient rinse the mouth with water and then expectorate deep cough sputum directly into a sterile, leak- proof, screw-cap sputum collection cup or sterile dry container. Refrigerate specimen at 2-8°C up to 72 hours; if exceeding 72 hours, freeze at -70°C and ship on dry ice. Upper respiratory tract Nasopharyngeal swab AND oropharyngeal swab (NP/OP swab). Use only synthetic fiber swabs with plastic shafts. Do not use calcium alginate swabs or swabs with wooden shafts, as they may contain substances that inactivate some viruses and inhibit PCR testing. Place swabs immediately into sterile tubes containing 2-3 ml of viral transport media. NP/OP specimens can be combined, placing both swabs in the same vial. Refrigerate specimen at 2-8°C up to 72 hours; if exceeding 72 hours, freeze at -70°C and ship on dry ice. Nasopharyngeal swab - Insert a swab into the nostril parallel to the palate. Leave the swab in place for a few seconds to absorb secretions. Swab both nasopharyngeal areas. Oropharyngeal swab (e.g., throat swab) - Swab the posterior pharynx, avoiding the tongue. Nasopharyngeal wash/aspirate or nasal aspirate. Collect 2-3 mL into a sterile, leak-proof, screw-cap sputum collection cup or sterile dry container. Refrigerate specimen at 2-8°C up to 72 hours; if exceeding 72 hours, freeze at -70°C and ship on dry ice. R.B. McFee / Disease-a-Month 63 (2017) 240–278 267 Serum Serum (for serologic testing) For serum antibody testing: Because we do not want to delay detection of MERS infection and since the prevalence of MERS in the US is low, serologic testing on a single serum sample collected 14 or more days after symptom onset may be beneficial. This is in contrast to serologic testing for many other respiratory pathogens which require collection and testing of acute and convalescent serum specimens. Serologic testing is currently available at CDC upon request and approval. Please be aware that the MERS-CoV serologic test is for research/surveillance purposes and not for diagnostic purposes - it is a tool developed in response to the MERS-CoV outbreak. Contact CDC's Emergency Operations Center (EOC) (770-488-7100) for consultation and approval if serologic testing is being considered Serum (for rRT-PCR testing) For rRT-PCR testing (i.e., detection of the virus and not antibodies): A single serum specimen collected optimally during the first 10-12 days after symptom onset is recommended. Note: The kinetics of MERS-CoV are not well understood. Once additional data become available, these recommendations will be updated as needed. Minimum serum volume needed The minimum amount of serum required for MERS-CoV testing (either serologic or rRT-PCR) is 200 mL. If both MERS-CoV serology and rRT-PCR tests are planned, the minimum amount of serum required is 400 mL (200 mL for each test). Serum separator tubes should be stored upright for at least 30 minutes, and then centrifuged at 1000–1300 relative centrifugal force (RCF) for 10 minutes before removing the serum and placing it in a separate sterile tube for shipping (such as a cryovial). Refrigerate the serum specimen at 2-8°C and ship on ice-pack; freezing and shipment of serum on dry ice is permissible. Children and adults: Collect 1 tube (5-10 mL) of whole blood in a serum separator tube. Infant: A minimum of 1 mL of whole blood is needed for testing pediatric patients. If possible, collect 1 mL in a serum separator tube. Shipping Specimens from suspected MERS cases must be packaged, shipped, and transported according to the current edition of the International Air Transport Association (IATA) Dangerous Goods Regulations. Shipments from outside of the United States may require an importation permit that can be obtained from CDC. Specimens should be stored and shipped at the temperatures indicated above. If samples are unable to be shipped within 72 hours of collection, they should be stored at -70°C and shipped on dry ice. When shipping frozen specimen from long distances or from international locations, it is best to use a combination of dry ice and frozen gel ice-packs. The gel ice-packs will remain frozen for a day or two after the dry ice has dissipated. All specimens must be pre-packed to prevent breakage and spillage. Specimen containers should be sealed with Par- afilms and placed in ziplock bags. Place enough absorbent material to absorb the entire contents of the Secondary Container (containing Primary Container) and separate the Primary Containers (containing specimen) to prevent breakage. Send specimens with cold packs or other refrigerant blocks that are self-contained, not actual wet ice. This prevents leaking and the appearance of a spill. When large numbers of specimens are being shipped, they should be organized in a sequential manner in boxes with separate compartments for each specimen. Additional useful and detailed information on packing, shipping, and transporting specimens can be found at Interim Laboratory Biosafety Guidelines for Handling and Processing Specimens Associated with Middle East Respiratory Syndrome Coronavirus (MERS-CoV) (https://www.cdc.gov/coronavirus/mers/guidelines-lab-biosafety.html). CDC recommends against the following: � Do not place any dry ice in the "Primary Container" or "Secondary Container", foam envelopes, ziplock bags, cryovial boxes, or hermetically sealed containers. � Do not place Primary Containers sideways or upside down in ziplock bags. � Do not place any paperwork in the Secondary Containers or ziplock bags, so as not to damage the paperwork. � Do not use biohazard/autoclave bags to prepack your materials due to the inadequate seal of these bags. For additional information, consultation, or the CDC shipping address, contact the CDC Emergency Operations Center (EOC) at 770-488-7100. Specimens should be shipped for overnight delivery - if Saturday delivery is planned, special arrangements must be made with the shipping company. R.B. McFee / Disease-a-Month 63 (2017) 240–278 268 Treatment As of this edition, there are no commercially available MERS CoV antivirals. The mainstay of therapy for MERS CoV remains supportive care, especially respiratory care, while managing circulatory, renal, hepatic and neurological function, as well as protecting against secondary infections. Although attempted in both the SARS CoV and early MERS CoV outbreaks, immune based interventions – interferon – resulting in equivocal outcomes. Non-human primate studies using IFN a2b, and Ribavirin against MERS CoV demonstrated improved outcomes. However, it is worth noting treatment was initiated soon after viral infection initiated; this is unlikely going to be the case with human infection, where a delay in presentation to health care, or delayed diagnosis will likely preclude the same rapidity of treatment that occurred in the study [6–8,32,33]. Interventions Attempted The role for interferon in MERS CoV remains unclear; clinical trials are needed to better characterize successful stra- tegies. But the limited number of cases make such studies difficult. In addition to various interferon treatment protocols, Ribavirin – a potent nucleoside analog – has been utilized against RNA viruses with varying degrees of success [7,32,33]. Unfortunately Ribavirin presents a risk for adverse effects including hemolytic anemia. Interferon is not without side effect risk either. The early use of corticosteroids in SARS CoV infected patients resulted in increased viral load, critical care/intensive care unit admission, and death [7]. Other approaches to CoV include neutralizing antibodies from convalescent plasma or hyperimmune globulin; these may hold some promise in reducing the CFR [36–38]. Convalescent plasma was shown to decrease mortality in SARS CoV patients if provided to patients within 14 days of illness [36]. However in order for this to be effective, rapid diagnosis of patients, and survivors is required in order to obtain, and utilize these interventions. Towards that end, a network for convalescent plasma is being assembled, allowing safety, effectiveness and logistic feasibility testing. [37]. That said, to date no host derived interventions have been shown to consistently confer significant benefit to severely ill MERS CoV patients via controlled study. While to date there are no antivirals currently licensed for use against MERS CoV, some candidate drugs are in devel- opment. Two categories of candidates are showing early promise. An adenine analogue that can be incorporated into viral RNA, which can disrupt virus replication, and has shown in vitro activity against MERS CoV, as well as benefit against Ebola in non human primates (NHPs). Also there is a nucleoside analogue for treatment of filoviruses, CoV, and other RNA viruses. Researchers are working on other molecular approaches to treat CoV [7,39,40]. Another promising approach includes monoclonal antibodies (mAbs). mAbs have already demonstrated benefit against certain cancers and autoimmune disorder management [7,38]. To date the only pathogen for which there is a licensed mAb is respiratory syncytial virus (RSV). Prevention WHO recommends standard precautions with all patients, especially those displaying early signs of respiratory illness, as the diagnosis – whether common cold, or MERS CoV or RSV or pertusis or other pathogen related infection. Also droplet precautions should be added to standard precautions when providing care to such patients, including those with acute respiratory illness. Although eye protection is recommended for probable or confirmed cases of MERS CoV, and airborne precautions for aerosol generating procedures, this would seem prudent even in cases clearly not MERS CoV or SARS CoV. From an infection control perspective, among the known human coronaviruses they are capable of surviving on en- vironmental surfaces for up to 3 hours [11]. The SARS and MERS experiences, as well as previous HCoV, underscore the threat of transmissibility; coronaviruses may be transmitted from person-to-person by droplets, hand contamination, fo- mites, and small particle aerosols. Underscoring the risk of nosocomial infection, in 2015 there was an outbreak in the Republic of Korea involving 186 cases from 17 health care settings. It was the result of a single imported case. Human to human transmission to family contacts, healthcare workers and patients sharing the same wards. Of note, environmental contamination, and the potential for MERS CoV to survive on surfaces may have contributed to the outbreak. Other recent outbreaks in Jordan and the National Guard Hospital in Riyadh have occurred involving 16 and 100 cases respectively. Not unlike the potential for other pathogens to spread, overcrowding in health care and residential facilities can facilitate transmission for MERS CoV, as with other respiratory contagions. As such, lessons learned from Saudi Arabia, Korea and elsewhere can serve to catalyze efforts to implement enhanced infection control in our clinical practice settings. Avoiding camels, especially dromedary camels, farms, as well as not consuming raw milk, urine, or meat are also worth considering. Camels infected with MERS CoV may not appear ill. If contact with animals, especially dromedary camels cannot be avoided, strict hand washing is recommended. Personal protection, including face/eye if working with camels or other animals. Patients who must travel to the region are encouraged to present to a health care facility especially if fever and re- spiratory symptoms develop. According to a WHO update, multiple cases from the United Arab Emirates, Qatar, Oman, R.B. McFee / Disease-a-Month 63 (2017) 240–278 269 Kuwait, and Bahrain have links to dromedary camels. These patients were thought to be infected via contact with infected dromedaries or close primary cases (UAE). A good practice for anyone who works with potential contaminants – whether in the US or Middle East farm – remove work clothes that may carry materials from farms and animal contact (Poster 1) [42]. To date few cases have occurred in Europe or the US. However with the emergence of medical tourism – cosmetic and advanced surgeries – patients who reside in the Middle East may bring with them diseases endemic to the region, including MERS CoV. The astute clinician will be aware of potential importation of illness. The CDC provides a following travel warning for persons planning on visiting regions where MERS CoV remains (Poster 1). For more information: call 800-CDC-INFO (232-4636) or visit www.cdc.gov/travel VACCINES Vaccination is a critically important preventive measure, but as of publication, no MERS CoV vaccine is available. MERS-CoV continues to cause illness since its emergence in 2012, and with a mortality rate estimated at 35.6%, it remains a potential pandemic threat, and dangerous disease causing pathogen. As with SARS CoV and other viral threats of public health concern, there is a great need for both prophylactic measures – vaccines, and more targeted therapies. There is significant research effort underway internationally to develop an effective vaccine. As with the SARS CoV, there are a variety of approaches. One attempt which shows early animal efficacy is by a vaccine candidate consisting of chimeric virus-like particles (VLP) expressing the receptor binding domain (RBD) of MERS-CoV. The researchers have fused canine parvovirus (CPV) VP2 structural protein gene with the RBD of MERS-CoV; it self-assembles into chimeric, spherical VLP (sVLP). This sVLP retained certain parvovirus characteristics, such as the ability to agglutinate pig erythrocytes, and structural mor- phology similar to CPV virions. Immunization with sVLP induced RBD-specific humoral and cellular immune responses in mice. sVLP-specific antisera from these animals were able to prevent pseudotyped MERS-CoV entry into susceptible cells, with neutralizing antibody titers reaching 1: 320. Of note, Interferon (IFN) - IFN-γ, IL-4 and IL-2 secreting cells induced by the RBD were detected in the splenocytes of vaccinated mice by ELISpot. Mice given sVLP or an adjuvanted sVLP vaccine elicited T-helper 1 (Th1) and T-helper 2 (Th2) cell-mediated immunity. Although early stage, research sVLP displaying the RBD of MERS-CoV may become, or lead to an effective vaccine against MERS-CoV. Human research is needed [41]. Table 1: Persons Under Investigation PUI [34]. CLINICAL FEATURES EPIDEMIOLOGICAL RISKS Severe illness and A history of travel from countries in or near the Arabian Peninsula2 within 14 days before symptom onset, or close contact3 with a symptomatic traveler who de- veloped fever1 and acute respiratory illness (not necessarily pneumonia) within 14 days after traveling from countries in or near the Arabian Peninsula2. Fever1 and pneumonia or acute respiratory distress syn- drome (based on clinical or radiological evidence) – or – A member of a cluster of patients with severe acute respiratory illness (e.g., fever1 and pneumonia requiring hospitalization) of unknown etiology in which MERS- CoV is being evaluated, in consultation with state and local health departments in the US. Milder illness and A history of being in a healthcare facility (as a patient, worker, or visitor) within 14 days before symptom onset in a country or territory in or near the Arabian Peninsula2 in which recent healthcare-associated cases of MERS have been identified. Fever1 and symptoms of respiratory illness (not ne- cessarily pneumonia; e.g., cough, shortness of breath) Fever1 or symptoms of respiratory illness (not necessarily pneumonia; e.g., cough, shortness of breath) and Close contact3 with a confirmed MERS case while the case was ill. Footnotes 1Fever may not be present in some patients, such as those who are very young, elderly, immunosuppressed, or taking certain medications. Clinical judgment should be used to guide testing of patients in such situations. 2Countries considered in the Arabian Peninsula and neighboring include: Bahrain; Iraq; Iran; Israel, the West Bank, and Gaza; Jordan; Kuwait; Lebanon; Oman; Qatar; Saudi Arabia; Syria; the United Arab Emirates (UAE); and Yemen. 3Close contact is defined as a) being within approximately 6 feet (2 meters), or within the room or care area, of a confirmed MERS case for a prolonged period of time (such as caring for, living with, visiting, or sharing a healthcare waiting area or room with, a confirmed MERS case) while not wearing recommended personal protective equipment or PPE (e.g., gowns, gloves, NIOSH-certified disposable N95 respirator, eye protection); or b) having direct contact with infectious se- cretions of a confirmed MERS case (e.g., being coughed on) while not wearing recommended personal protective equip- ment. See CDC's Interim Infection Prevention and Control Recommendations for Hospitalized Patients with MERS(https:// www.cdc.gov/coronavirus/mers/infection-prevention-control.html). Data to inform the definition of close contact are lim- ited; considerations when assessing close contact include the duration of exposure (e.g., longer exposure time likely R.B. McFee / Disease-a-Month 63 (2017) 240–278 270 increases exposure risk) and the clinical symptoms of the person with MERS (e.g., coughing likely increases exposure risk). Special consideration should be given to those exposed in healthcare settings. For detailed information regarding healthcare personnel (HCP) please review CDC Interim U.S. Guidance for Monitoring and Movement of Persons with Potential Middle East Respiratory Syndrome (MERS-CoV) Exposure(https://www.cdc.gov/coronavirus/mers/hcp/monitoring-movement-gui- dance.html). Transient interactions, such as walking by a person with MERS, are not thought to constitute an exposure; however, final determination should be made in consultation with public health authorities. For more information: call 800-CDC-INFO (232-4636) or visit www.cdc.gov/travel Poster 1 [42] REFERENCES [1] Image of Middle East Respiratory Syndrome (MERS) Coronavirus as isolated by The National Institute of Allergy and Infectious Diseases (NIAID) 〈https://phil.cdc.gov/phil/details.asp〉 Last accessed 03/12/17. [2] Zaki AM, van Boheemen S, Bestebroer TM, et al. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 2012;367: 1814–1820. [3] Bermingham A. Severe respiratory illness caused by a novel coronavirus in a patient transferred to the United Kingdom from the Middle East, September 2012. Euro Surveillance. 2012;17:20290. [4] DeGroot RJ. Middle East respiratory syndrome coronavirus (MERS – CoV) announcement of the Coronavirus Study Group. J Virol. 2013;87:7790–7792. [5] Assiri A, Al-Tawfiq JA, Al-Rabeeah AA, et al. Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study. Lancet Inf Dis. 2013;13:752–761. [6] World Health Organization (WHO) MERS update and Global Summary. http://www.who.int/emergencies/mers-cov/en/ Last accessed 03/12/17. [7] Modjarrad K. Treatment strategies for Middle East Respiratory Syndrome Coronavirus. J Virus Eradication. 2016;2:1–4. [8] Centers for Disease Control and Prevention (CDC) Middle East Respiratory Syndrome (MERS) Coronavirus 〈https://www.cdc.gov/coronavirus/mers/ index.html〉 Last accessed 03/12/17. [9] Chan JFW, Chan KH, Choi GKY, To KKW, et al. Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012: implications for disease pathogenesis and clinical manifestation. J Infect Dis. 2013;207:1743–1752. [10] World Health Organization Middle East Respiratory Syndrome Coronavirus Emergency Preparedness Response 〈http://www.who.int/csr/don/21-june- 2016-mers-saudi-arabia/en/〉 Last accessed 03/12/17. [11] Sizun J, Yu MW, Talbot PJ. Survival of human coronaviruses 229E and OC43 in suspension after drying on surfaces: a possible source of hospital- acquired infections. J Hosp Infect. 2000;46:55–60. 〈http://SARSReference.com/lit.php?id¼11023724〉. [12] Omrani AS, Shalhoub S. Middle East Respiratory Syndrome Coronavirus (MERS CoV): what lessons can we learn? J Hosp Infect. 2015;91(3)188–196. [13] Poletto C, Pelat C, Levy-Bruhl D, et al. Assessment of the Middle East respiratory syndrome coronavirus (MERS – CoV) epidemic in the Middle East and risk of international spread using a novel maximum likelihood analysis approach. Euro Surveillance. 2014:19. [14] Majumder MS, Riveres C, Lofgren E, Fisman D. Estimation of MERS – coronavirus reproductive number and case fatality rate for the Spring 2014 Saud Arabia outbreak insights from publicly available data. PloS Curr. 2014;6. [15] Michigan Center for Public Health Preparedness, epidemiology of Ro and pathogen transmission. 〈https://practice.sph.umich.edu/micphp/epicentral/ basic_reproduc_rate.php〉 Last accessed 02/13/17. R.B. McFee / Disease-a-Month 63 (2017) 240–278 271
2017 Middle East respiratory syndrome coronavirus (MERS-CoV) infection
2017 • 4 Pages • 557.79 KB
2013 Middle East Respiratory Syndrome coronavirus (MERS CoV)_ Update 2013
2014 Middle East respiratory syndrome coronavirus (MERS-CoV)_ Prevention in travelers
2013 Middle East Respiratory Syndrome Coronavirus (MERS-CoV)_ A Perpetual Challenge
2017 Update on therapeutic options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
2016 Clinical spectrum of the Middle East respiratory syndrome coronavirus (MERS-CoV)
2014 Middle East respiratory syndrome coronavirus (MERS-CoV)_ evidence and speculations
2014 Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV)
2015 Middle East respiratory syndrome coronavirus (MERS-CoV)_ animal to human interaction
2014 Emerging Infectious Diseases __ Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) Infection
2014 Unanswered questions about the Middle East respiratory syndrome coronavirus (MERS-CoV)
2017 Retrospective, epidemiological cluster analysis of the Middle East respiratory syndrome coronavirus (MERS-CoV) epid
2014 Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
2014 • 2 Pages • 54.2 KB
2015 Middle East respiratory syndrome coronavirus (MERS-CoV)_ what lessons can we learn_
2014 Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection_ Chest CT Findings
2018 Lack of seasonal variation of Middle East respiratory syndrome coronavirus (MERS-CoV)


text:
La Région des North West Slopes (littéralement des versants Nord-Ouest) en Nouvelle-Galles du Sud en Australie correspond généralement à la région limitée à l'est par les Plateaux du nord, au sud par la région Centre-Ouest, à l'ouest par la région du Far West australien et au nord par le Queensland. La région correspond sensiblement à la zone des North West Slopes and Plains de l'Australian Bureau of Meteorology.

Elle est plus élevée, plus moutonnante et plus humide dans sa partie Est que dans sa portion ouest. La région est traversée par divers affluents de la rivière Darling, qui coule un peu plus à l'est, comme les rivières Barwon, Gwydir et Namoi Rivers.

Elle comprend les villes de Gunnedah, Warialda, Manilla, Boggabri, Mungindi, Narrabri, Moree, Quirindi, Wee Waa, Tamworth et de nombreux villages.

La région a toujours été une zone importante de culture du blé mais ces dernières décennies, les cultures irriguées, notamment celles de coton, se sont considérablement développées. Les principales exportations sont le coton, le charbon, le bœuf, l'agneau et le porc, les céréales et les oléagineux.

La région est traversée par la New England Highway, la Newell Highway, la Kamilaroi Highway, l'Oxley Highway, la Gwydir Highway et par des voies de chemin de fer comme la Main Western railway line, reliant Bourke à Sydney avec une connexion vers le port de Newcastle. La ligne ferroviaire Main North railway line ne continue plus jusqu'à la frontière du Queensland, mais Werris Creek, Tamworth et Kootingal sont encore desservies par le service Countrylink Xplorer entre Sydney et Armidale.

Le Parc national du Mont Kaputar, près de Narrabri, se situe dans la région.

Cette région est souvent considérée comme faisant partie de la Nouvelle-Angleterre. Parfois, la région est également connue comme la New England North West ou, moins fréquemment, la Northern Inland Region quand elle inclut aussi les Northern Tablelands.

Les zones d'administration locale de la région comprennent le Comté de Gunnedah, le Comté de Liverpool Plains, le Comté de Moree Plains, le Comté de Narrabri et le Conseil de la région de Tamworth.

Région en Nouvelle-Galles du Sud

redpajama_set_name: RedPajamaWikipedia


I have two different cards on my single account both checking. I used the app to transfer from one to the other it says that it's there but unusable. How long is the wait time before my funds can be used?
Thanks for choosing to connect with us on TD Helps today, Timothy. As we would like to assist you directly, please know that we do not have access to your personal information as this is considered an unsecured forum. We recommend for you to give us a call, we're available 24/7 at 888-751-9000. Upon account verification, we will be more than happy to look into this for you. You also have the option of visiting your local TD Bank Store. For a listing of hours and locations, take a look here: http://bit.ly/TDStores. Hope this helps and have a great day.


This is a dish I have long adored. I grew up in the South. A plate of mashed potatoes, gravy and some chicken fried steak is heavenly. Healthy? Hell no! Vegan? In your dreams!
Well, dreams can come true. This is healthy, vegan and really hits the spot. It's not the easiest recipe you'll find here but it's perfect for a special occasion. Or a weekend. Or a really bad day. Those are all special in my book. Heck, survived Monday? SPECIAL!!!
Hunger pains are setting in, folks! I need to make another batch ASAP!!!
*To make the crust you need a special piece of equipment: a spray bottle. That has only been used for WATER, please! You can grab these at almost any store (grocery, hardware, beauty supply.) It makes this work. Oh if you have one of those little refillable oil sprayers that will work as well but you'll need to clean it out and fill it with water.
*The recipe calls for 4 oz tempeh to add flavor and texture to the cutlets. If you don't have any tempeh or can't find it (or don't eat it) you can use 4 oz drained chickpeas instead.
*You can easily double this recipe and freeze the leftovers. After baking the cutlets let the ones you want to freeze cool and then freeze them. I would say that they will last about 6 weeks in the freezer but that is me being super conservative.
*The coating doesn't get flakey like a usual chicken fried steak but kind of becomes part of the seitan. You can double dip the cutlet to get a thicker crust. Just dip in the soy milk, the coating, shake excess off, dip in soy milk again and in coating again. Then bake as directed.
Baked Vegan "Chicken Fried Steak"
Puree the tempeh in a food processor until very fine (Alternatively you can do this with a fork but it will take a lot longer and may not get to the desired consistency.) Add the tempeh, vital wheat gluten and onion powder to the bowl and mix thoroughly. Now add in your liquids. Mix together and knead the dough for 3-4 minutes. Let it rest for 5 minutes. Now separate into 4 portions and stretch each portion out into a thin cutlet shape.
Mix together everything but the soy milk for the coating. Put the coating on a plate and your soy milk into a bowl. Now dip your cutlet into the soy milk. Dip it into the coating making sure that it gets totally covered. Shake off any excess and place onto the parchment lined baking sheet. Repeat with remaining cutlets.
Now turn your spray bottle to the "mist" setting and gently spray the tops of the cutlets. You want to get all of the floury mess wet but not soggy.
Slide the baking sheet into the oven and bake for 20 minutes. Flip the cutlets over and spray again with the water bottle. Bake for 20 minutes more or until lightly browned and crispy.
Let the cutlets rest for 5 minutes and then serve. Enjoy!


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RANCHO DOMINGUEZ, CALIFORNIA – BI Nutraceuticals, a global full service manufacturer and supplier of plant based ingredients in the United States, announced its acquisition by the Martin Bauer Group, a global botanical expert. Effective March 25, 2019, the partnership allows both organizations to broaden their portfolio of ingredients, while being supported by an expansive manufacturing platform.
BI's partnership with the Martin Bauer Group allows the company to expand its food, beverage and dietary supplement ingredient offerings. Both companies share a long-standing reputation as experts in quality sourcing and manufacturing processes. This commitment will help further their growth as the demand for safe and responsibly sourced ingredients continue to grow in the domestic market.
"The addition of BI Nutraceuticals to our Group buttresses our commitment to reliable, quality, safe and clean label raw materials, meeting an increasing demand from our customers and consumers," stated Ennio Ranaboldo, CEO of Martin Bauer Group in North America. The two companies will continue to operate independently, and further communications will be issued to ensure seamless integration both internally and for all customers.
For more information on BI or its acquisition by the Martin Bauer Group, please visit www.botanicals.com.
BI is a global full-service supplier of dietary supplement and functional food ingredients including plant-based powders and teas, standardized and ratio extracts, proteins, fibers, vitamin mineral premixes, custom blends, granular ingredients and other specialty processes. BI offers more than 200 ingredients that have been determined as safe for use in foods and beverages by the FDA or FEMA, the Flavors and Extracts Manufacturers Association. In 2002, BI pioneered a steam sterilization process, known as Protexx HP® Green Steam™, which is the industry's only species-specific, organic sterilization method with a validated kill step. All BI ingredients undergo stringent quality analysis that includes heavy metals, pesticides, irradiation, and Identilok®, BI's species identification process. The company has also developed a proprietary process, UltraHD®, which creates high-density herbal powders allowing for superior flow and less dusting during the manufacturing process. For more information, visit www.botanicals.com.
Since 1930 the Martin Bauer Group stands for outstanding expertise in botanical products worldwide. We work with our customers to develop tailor-made solutions for the Tea, Beverage, Food and Dietary Supplements industries. Our products are based on responsibly sourced, high-quality botanical raw material from more than 80 countries. With more than 20 manufacturing sites and sales units worldwide, we keep our finger on the pulse of our customers' local markets. Our goal is to drive creativity and innovation for successful products of tomorrow. The Martin Bauer Group is part of the nature network®. More than 3,600 employees worldwide — many of them with decades of experience — work to maintain your competitive edge. https://www.the-nature-network.com/en/.