text:
import unittest
import requests
import time

from . import utils

class StartFailBase (object):

  def test_start (self):
    try:
      self.exp_sdk.start(**self.credentials)
    except self.exp_sdk.RuntimeError:
      pass
    else:
      raise Exception

class StartSuccessBase (object):

  def test_start (self):
    self.exp_sdk.start(**self.credentials)

class DeviceStartBase (utils.Base):

  def setUp (self):
    super(DeviceStartBase, self).setUp()
    self.credentials = self.device_credentials

class UserStartBase (utils.Base):

  def setUp(self):
    super(UserStartBase, self).setUp()
    self.credentials = self.user_credentials

class ConsumerStartBase (utils.Base):

  def setUp(self):
    super(ConsumerStartBase, self).setUp()
    self.credentials = self.consumer_credentials

class TestNoDeviceUuid (StartFailBase, DeviceStartBase, unittest.TestCase):

  def setUp(self):
    super(TestNoDeviceUuid, self).setUp()
    self.credentials['uuid'] = None

class TestNoDeviceSecret (StartFailBase, DeviceStartBase, unittest.TestCase):

  def setUp(self):
    super(TestNoDeviceSecret, self).setUp()
    self.credentials['secret'] = None

class TestAllowPairing (StartSuccessBase, DeviceStartBase, unittest.TestCase):

  def setUp(self):
    super(TestAllowPairing, self).setUp()
    self.credentials['uuid'] = None
    self.credentials['allow_pairing'] = True
    self.credentials['secret'] = None

class TestNoUsername (StartFailBase, UserStartBase, unittest.TestCase):

  def setUp(self):
    super(TestNoUsername, self).setUp()
    self.credentials['username'] = None

class TestNoPassword (StartFailBase, UserStartBase, unittest.TestCase):

  def setUp(self):
    super(TestNoPassword, self).setUp()
    self.credentials['password'] = None

class TestNoOrganization (StartFailBase, UserStartBase, unittest.TestCase):

  def setUp(self):
    super(TestNoOrganization, self).setUp()
    self.credentials['username'] = None

class TestNoConsumerUuid (StartFailBase, ConsumerStartBase, unittest.TestCase):

  def setUp(self):
    super(TestNoConsumerUuid, self).setUp()
    self.credentials['uuid'] = None

class TestNoConsumerApiKey (StartFailBase, ConsumerStartBase, unittest.TestCase):

  def setUp(self):
    super(TestNoConsumerApiKey, self).setUp()
    self.credentials['api_key'] = None


text:
Il Torneo di Montreux 1930 fu la 9ª edizione della Coppa delle Nazioni; la manifestazione venne disputata in Svizzera nella città di Montreux dal 20 al 21 marzo 1921.
La competizione fu organizzata dal Montreux Hockey Club.
Il torneo fu vinto dallo Faversham Hockey Club per la 1ª volta nella sua storia.

Squadre partecipanti

Svolgimento del torneo

Risultati

Classifica

Campioni

Collegamenti esterni

1930

redpajama_set_name: RedPajamaWikipedia


Join us for the fly fishing trip of a lifetime!
We fish year-round, throughout central Pennsylvania. Our home stream is the renowned Letort Spring Run, located in Carlisle, Cumberland County, Pennsylvania.
Time to Catch a Striper on a Fly Rod!


Most affordable active stabilizer on the market. Made from high impact strength composite with a powder filled chamber. The powder will not change with temperature or humidity giving a more consistent performance.
Turn your broken arrows into your own custom stabilizer. We supply everything except the inserts, glue, and arrows. Target kit must be cut down 2 inch less then desired length.
Turn your broken arrows into your own custom stabilizer. We supply everything except the inserts, glue, and arrows. Hunting kit must be cut down 3 inch less then desired length.
Rear mount String Stop with the following features, powder filling, super soft rubber cushion, adjustable base. The stop rod itself must be cut for the desired length needed to fit your bow.


Are you a Coverager Community member? If yes, Login to RSVP, or join the Community here (meetups are exclusive to members).
As the gracious host of this meetup, Ask Kodiak requested a theme close to their heart – appetite. With two patties, American cheese, pickles, and spicy sauce living between a buttery pretzel bun, Le Big Matt burger by Emmy Squared is one of the greatest ways to bring their appetite-themed event to life.
So, bring your appetite on Wednesday, March 13th, to Emmy Squared (East Village) for a fun evening filled with food, drinks and great company.


text:
Stepping Into Daddy's Shoes
Lately, Tad the 2 and a half year old boy I watch, has been fascinated by his father's shoes. His father is a tall man and has big shoes. Tad likes to pull his father's well-worn boots out of his closet and climb carefully into them. Then he has to walk in them - a clunky kind shuffling. It's interesting to watch the transformation that takes place in his mind and method. He stands up, adjusts his weight, then the hands go on the hips, and a very suave Big Boy swagger kicks in. "I'm the Dad," he says proudly and with purpose. Then we go shuffling about the house and yard looking for Dad size jobs for him to do. He looks at everything with an eye toward it's potential. He's mended fences, raked leaves and rocks, trimmed the bushes and carried his small pile of clipped leaves to the giant leaf pile out at the curb, "just like a dad," he says. Today he talked to me about 'shaving whiskers' like his Dad.
BUT, here's the best part - his idea of "Big" and "Dad," extend to love, courtesy and thoughtfulness. He carried the pillow for me - 'like a Dad', he said. He brought me a blanket - 'like a Dad', he said. He ran and brought me my phone when a text message came in 'like a Dad', he says. Tad required a Bandaid today. He also required a "Bandaid Buddy" - that's me. I took care of him first, then he opened a Bandaid and placed it on my forehead. I thanked him and told him I felt much better. I told him he was very good at taking care of me putting on Bandaids, "Yes," he said, "like a Dad".
Later, as I was cleaning cat poo from around his sand box (deposits left by the free-roaming neighborhood menace), Tad pushed the small trash can he watched me making trips to, up close to me for easier access. I hadn't asked him too. Heck I hadn't even thought of it myself. I was surprised by his action. Not because he isn't a sweet boy, he is. I was surprised that he, being only two and a half saw the situation and figured out all on his own that what he could do for me would be helpful. Being surprised as I was, I turned and looked at him. He was now crouched close beside me in his Daddy's big ol' boots, "Tad that was a very helpful, thoughtful thing to do - Thank You so much". He smiled and said, "just like a Dad." Melt my heart. Yes, Tad, just like a real Dad. You don't know this yet Sweet Little Man, but there aren't enough of those kinds of Dad's to go around these days.
This says a lot about what goes on in this little boys world. His parents, both of them are hard working, self-sacrificing, openly loving and devoted parents. They don't scrimp on discipline and guidance. They don't scrimp on teaching and new experiences. They don't scrimp on fun. And they don't scrimp on loving care for Tad or for one another. They don't lecture. They teach by example. Rare indeed. This little boy doesn't know how lucky and blessed he is, but I do.
I also know how blessed I am to have these three people in my life. Daily, I get a quiet dose of love and family that touches me and reaffirms my belief in the beauty and power of love, and it's far reaching affects.
The parents of this fine young lad, have a few pictures in their bedroom but one really stands out. It is one of the most beautiful, moving photographs I've ever seen. It's a wide panoramic shot, taken against a hill covered with tall golden grass and nothing else. Perfectly placed at one-third frame are Tad's parents - before they were parents, when they were just two people very much in love. They are knee deep in the grasses, pressed front to front. They are wrapped tightly and lovingly in each other's arms, sides of their faces visible. They are kissing. Not a steamy scandalous kiss, but a kiss clearly expressing their deep love for, and devotion to one another. Beautiful, so beautiful. It is a powerful image. Tad has seen it every day of his life. He doesn't realize it now, but this image will become very important to him in the years to come as he grows into the world and the man he will become. Right now I'm sure he takes for granted that all people are this way. Too soon, he will learn they are not. This image of, and the knowledge of what these two special people mean to each other and how they care for each other will be embedded in his character. I'm sure it will serve him well when it's time for him to formulate and understand his own ideas toward relationships. Tad will leave a mark in this world, as we all do. I hope his mark will be as powerful as his parents.
p.s. - As he and his parents live their lives, surviving changes and each others aging, I hope this image of his parents is how he will always chose to remember and see them - young, beautiful, in love, and devoted to one another.

redpajama_set_name: RedPajamaCommonCrawl


ERK1 2 might be activated transiently or persistently by MEK1 two and upstream MAP3Ks in conjunction with regulation and involvement of scaffolding proteins and phospha tases. There's abundant proof that survival fac tors can use the ERK1 two pathway to increase the expression of many professional survival BCL 2 proteins, not ably BCL two, BCL xL and MCL 1, by promoting de novo gene expression inside a variety of cell varieties. Clearly the ERK1 2 pathway can regulate many members in the BCL two protein relatives to attain cell survival. ERK1 2 signalling can supply safety against chemothera peutic cytotoxic medicines. It's proven previously sCLU plays an essential function in astrogliosis by stimulating the proliferation of astro cytes by activation of your extracellular signal regulated kinase one 2 signaling pathway. Shim and Chou et al. also found substantial relation between sCLU and ERK1 2 expression.
We hence more bonuses suggested that sCLU silencing sensitized pancreatic cancer cells to gemcitabine chemotherapy might through ERK1 2 signaling pathway. sCLU is not a standard druggable target and can only be targeted at mRNA levels. An antisense inhibi tor targeting the translation initiation internet site of human exon II CLU was developed on the Univer sity of British Columbia and out licensed to Onco GeneX Pharmaceuticals Inc. OGX 011, or custirsen, can be a second generation antisense oligonucleotide with a lengthy tissue half lifestyle of 7 days, which potently sup presses sCLU ranges in vitro and in vivo. OGX 011 enhanced the efficacy of chemotherapy, radiation, and hormone withdrawal by inhibiting expression of sCLU and enhancing apoptotic rates in preclinical xenograft versions of prostate, lung, renal cell, breast, and various cancers.
Within this examine, we review the impact of sCLU silencing by OGX 011 on sensitizion of pancreatic cancer cells to gemcitabine chemotherapy, and eluated the mechanisms. The human pancreatic cancer MIAPaCa two cells resistant to gemcitabine and BxPC 3 cells delicate to gemcitabine were bought from American Kind Culture Col lection. They were routinely cultured in DMEM supple mented with 10% fetal bovine serum in a 37 C incubator pop over to this website inside a humidified environment of 5% CO2. Development of transient transfection using a plasmid expressing human wt pERK Complete RNA was extracted from PANC one cells working with TRI zol reagent,in accordance towards the producers protocol. The cDNAs have been synthe sized working with the TaKaRa RNA polymerase chain response Kit. A complete length cDNA encod ing human wt pERK was cloned by PCR using 500 ng cDNA like a template and primers containing HindIII and BamHI restriction enzyme web pages. The PCR items had been ligated into pcDNA3. 1 to create the plasmid pcDNA3. one wt pERK. MIA PaCa two and BxPC 3 cells had been transfected using the pcDNA3.
Amongst the thirty miRNAs recognized, 29 had been down regulated during the IA tissue and 1 was upregulated. miRNAs identified from the microarray research had been validated implementing person true time qRT PCR assays. And 18 have been noticed to become signifi cantly unique among the IA and control groups with the 14 patients,and the p worth and FC were calculated,miR 142 5p was upregulated in microarray profile, but qRT PCR end result showed no signifi cance in between IAs and controls. The rest of the candidate miRNAs showed an expression tendency steady using the array end result, but with no statistical significance. The expression amounts of hsa mir one, hsa mir 7 one 3p, hsa mir 23b 5p, hsa mir 23b 3p, hsa mir 24 1 5p, hsa mir 28 5p, hsa mir 28 3p, hsa mir 29b two 5p, hsa mir 29c 5p, hsa mir 29c 3p, hsa mir 133a, hsa mir 133b, hsa mir 140 3p, hsa mir 143 5p, hsa mir 143 3p, hsa mir 145 5p, hsa mir 145 3p, hsa mir 455 5p have been down regulated at least two fold in IA compared with all the control group.
One can find 4 clusters amid these miRNAs. hsa mir one has mir 133a,hsa purchase LY2835219 mir 143 hsa mir 145,hsa mir 23b hsa mir 24 1,hsa mir 29b two hsa mir 29c. Some miRNAs play a role within the cardiovascular system. One example is, miR one is induced while in smooth muscle cell differentiation and increases the expression of SMC exact contractile proteins. miR 133 is known as a crucial regu lator of vascular smooth muscle cell phenotypic switch in vitro and in vivo. Also notable, miR 145 is connected on the thickness from the vessel wall, along with the absence of miR 145 could lessen the vessel thickness and as a consequence of hypotrophy of SMCs. miR 145 is down regulated fol lowing vascular damage, while in atherosclerosis, and in ex perimentally induced aneurysms. Integrated examination of misregulated miRNAs and mRNAs miRNAs modulate gene expression via each mRNA degradation and translational repression mechanisms, and miRNA mRNA regulatory networks are very complex.
PLX4720 A dataset of 681 genes designed from our mRNA micro array information paired with high predicted and experimentally observed targets to 18 miRNAs, which have been made use of for In genuity Pathway Analysis. IPA results uncovered major functions of these 681 widespread targets. Just about the most im pacted biological processes for IA including. migration of phagocytes, proliferation of mononuclear leukocytes, cell movement of mononuclear leukocytes, cell motion of smooth muscle cells, differentiation of macrophages etc. The functions are picked and arranged through the z score which indicates the predicted degree of individuals functions. A favourable worth means a rise within the func tion, whereas a negative value indicates a reduce the perform, and the p value indicates the significance of each perform. IPA predicted quite possibly the most impacted biological processes for IA based within the miRNAs and their targets.
A few activators had been also existing activator of CDK5, CDK7 that collectively with CCNH and MAT1 functions as a CDK activating kinase and CCNC that interacts with CDK8. In holding with the postulate, these inhibitory genes showed quick downreg ulation upon IL2 activation. Concomitantly, there was an early grow in expression of genes associated with regulating common transcription, initiation regulation of DNA replication, DNA repair and translation management. Many genes involved in the G1 S phase within the cell cycle and BCCIP. activators CDC2, 7 and 6 members of cell cycle transcriptional regulators and associated proteins and many cyclins showed an enhanced expression at eight 24 hours. A loved ones of genes cru cial for DNA replication from the S phase showed optimum expression at 24 hrs. The majority of the M phase and anaphase regulators have been not upregulated. Interestingly, a few genes involved in the late phases of of cell cycle.
anaphase pro moting management and kintechore linked gene were extremely expressed by 24 hrs, suggesting that they may possibly serve some unique functions at earlier phases on the cell cycle. The proliferation marker PCNA showed substantial expression by 24 hours. Signal transduction JAK STAT pathway Cytokine signals mediating control of cell development and sur vival typically involve the JAK STAT pathway. Consequently, addition of IL2 to resting NK cells in culture custom peptide induced upregulation of an important upstream member of this pathway and important substrates and trancriptional mediators of STATs. Numerous adverse regulators in the JAK STAT pathway. supressors of cytokine signaling had been downregulated immediately after two hrs with IL2 stimulation, whereas other individuals were upregulated. Activation of JAK2 and JAK3 in response to IL2 in NK cells continues to be reported previously and implicated within the activa tion of STAT4 and STAT5, respectively.
These observations are in agreement with our findings that 7 of 8 STAT4 target genes examined and eight of 9 STAT5 targets showed increased expression in IL2 stimulated cell. Examination with the targets of STAT1 showed an increase in 13 of 15 tar get genes. The transcript amounts of JAK1, STAT3 and STAT2 did not display a consistent pattern around the two platforms and so they were not analyzed even more. TGF pathway Transforming growth element pathway selleck chemicals compound library regulates diverse cellular perform by means of SMAD pro teins, which regulate transcription by means of their interac tion with other transcription components as well as the recruitment of co repressors or co activators according to the cellular and functional context. 3 members of TGFB1 sort II receptors. BMPR2 and ACVR2A quite a few ligands and many members in the SMAD relatives. Co Smad and I Smad were upregulated in resting NK cells.
Consequently, stem cells can spontaneously modify fate in accordance with observa tions. This also permits us to response the 2nd query as to how reprogramming might be simulated in our model. In it's been proven that over expression of OCT4 can lead to reprogramming a somatic cell to an ESC. Having said that, the eciency is maximal to the amounts of OCT4 inside of a particular window. Our model can reproduce this consequence, and we show how the interaction involving OCT4, NANOG along with the dierentiation pathway gene G result in this outcome. Our simplied ESC network model considers a com bination of favourable and negative feedbacks among OCT4 SOX2 and NANOG and G. With stochastic sim ulations we show the permissive nature of this self contained network most cells retain pluripotency except for a fraction that get pushed in direction of dieren tiation. This model, is primarily based on an epigenetic eect by which OCT4 regulates NANOG, can be employed for reprogramming somatic cells into ESC.
The heterodimer OCT4 SOX2 is acknowledged to serve as an activator of OCT4, SOX2 and NANOG. As in,we simplify the interaction of OCT4 and SOX2 with NANOG as proven in Figure one. The suggestions involving NANOG and OCT4 SOX2 should be weak. Otherwise it could be inconsistent with low levels of NANOG and high ranges of OCT4 and SOX2 as pointed out in. Consequently, we never explicitly have selleck NANOG inducing OCT4 and SOX2 in contrast to refs. To describe both the embry onic as well because the dierentiated state, we involve G inside the circuit. One candidate for G is Sox17, which was shown to perform a role inside the handle of dierentiation of ESCs into added embryonic endoderm. SOX17 interferes with the self renewal system by inhibiting SOX2, OCT4 and NANOG. One other candidate for G is GATA6, and that is accountable for endoderm formation and in addition mutually antagonizes NANOG.
In,the authors assumed an external signal marketing dierentiation. On the other hand, in our method CAL101 the gene G is regulated through the ESC circuit itself, and therefore is aspect within the network which determines the cell fate. Our circuit also incorporates the dierentiation selling autocrine growth component FGF4, which can be shown schematically in Figure 1 to repress NANOG. It's been suggested that FGF4 acts upstream in the induc tion of dierentiation. The Fgf4 gene is expressed in mouse embryonic stem cells and only OCT SOX com plexes can promote its transcriptional activation. Inhibition of FGF4 in addition to GSK3 consolidates the ESC self renewal and pluripotency. As in,we have now presume mutual antagonism involving NANOG as well as the dierentiation gene G, likewise as activation of G by OCT4 SOX2. As shown in,above expression of OCT4 could both bring about the establishment or reduction with the stem cell fate, based on the level of OCUsing Swiss Webster mice it's been proven that NF ??B is activated in response to infection with C.
ERK one and two, JNK and p38 and IKK NF kB pathway. Quite a few studies have shown that some lively compounds inhibit LPS induced inflammatory cytokines production through the down regulation of NF ?B and MAPKs routines in RAW 264. 7 cells. So, we investi gated the result of WEL on activation of ERK1 2, JNK and p38 in LPS stimulated cells. Our success showed the phophorylation of JNK and ERK in response to LPS were induced with WEL treatment, whereas p38 phosphorylation was not impacted. These results indicated that anti inflammatory mech anism of WEL was mediated potentially through the downstream MAPKs pathway but independent of the activation of MAPK signaling pathway. NF kB activation instead of the phophorylation of MAPKs may possibly be involved in WEL decreased cytokines production. Equivalent phenomena have been also identified during the anti inflammatory effect of Cucurbitacin E, which was reported by Qiao J.
Having said that, the function as well as underlying mechanism of WEL induced activation of MAPKs in LPS stimulated cells are remained to become fur ther elucidated. In conclusion, WEL was shown to inhibit the produc tion of NO and PGE2 also as their upstream enzymes iNOS and COX 2 at protein level by way of inhibition of I?B phosphorylation and p65 nuclear translocation in LPS induced RAW 264. seven cells. The inhibition of iNOS selleck chemicals PD0332991 and COX 2 expression was mediated independent in the MAPK. Conclusions The results of our examine indicated that WEL exerted anti inflammatory effects by suppressing the NF ?B path way. Having said that, the effects of WEL on MAPKs pathway must be elucidated in further research. Introduction Resistance to anticancer medication stays a significant unre solved obstacle to effective chemotherapy. It has been estimated that most cancer deaths, if not all, are caused by chemotherapy failure simply because tumors immediately develop resistance after exposure to medicines.
So that you can de velop novel methods to combat cancer drug resistance and to make improvements to patient survival, a thorough below standing of its mechanisms syk kinase inhibitor is therefore badly essential. The triggers of cancer drug resistance are multifactorial, such as decreased accumulation increased dispos ition of anticancer medication, mutation of drug targets, en hanced cell repair and altered cell death pathways. However, probably the most widespread and extensively studied mechanism will be the overexpression from the vitality dependent ATP binding cassette drug efflux transporters this kind of as P glycoprotein. multidrug resistance connected protein. and breast cancer resistance protein. It truly is linked with an elevated efflux of cyto toxic medicines, creating multidrug resistance be induce cytotoxic drugs from distinct chemical structures are affected simultaneously. MicroRNAs are short endogenous non coding RNAs that repress gene expression inside a selection of eukaryotic organisms.
Discussion Remedy options for myxoid liposarcoma individuals with innovative sickness are poor. Just lately, the chemothera peutic drug Trabectedin showed promising effects in phase I and II trials in superior illness however adverse effects have also been reported, Little molecule focusing on, specifically with kinase inhibitors, has proven to become powerful and more distinct in lots of tumors with significantly less severe uncomfortable side effects than standard chemotherapeutic agents. To recognize new possible treatment options for myxoid liposarcoma patients with innovative sickness, we explored the kinome of myxoid liposarcoma cells in vitro and performed subsequent pathway analysis.
We previously established the reliability of kinome profiling working with Pepchip in untreated versus imatinib handled GIST882 cell line which properly identified the pathways regarded to be involved in GIST, In addition, we previously demonstrated the reliability of our analy sis and that is based on averaging results of a number of samples to selelck kinase inhibitor get an impression on the most activated kinases within a series of tumors, By on top of that per forming the Pepchip experiments inside the myxoid liposar comas cell lines immediately after serum starvation at the same time as by excluding cell cycle linked kinases from the analysis we established that the detected kinases from the current ana lysis are indeed tumor unique rather than associated to your high proliferation price from the myxoid liposarcoma cell lines. Also, by comparing with previously analyzed series of colorectal cancer and chondrosarcoma, at the same time as by evaluating with mesenchymal stem cells we could confirm that the listing of kinases was specific for myxoid liposarcomas.
We could demonstrate activation of the peroxisome proliferator activated receptor gamma pathway, which may be anticipated given that it's been shown to perform a pivotal function in adipocytic differentiation and is regulated from the FUS DDIT3 fusion product, The DDIT3 gene encodes a DNA harm inducible member in the C EBP family members of transcription variables and inhibits adipocytic AZD8931 conversion of preadipocytes, Transfection of key mesenchymal progeni tor and human fibrosarcoma cells with the FUS DDIT3 fusion protein induces a myxoid liposarcoma phenotype, Therapy of myxoid liposarcoma cells in vitro and in vivo with peroxisome proliferator activated receptors gamma agonists induced terminal differentia tion, though phase II research with the peroxisome proliferator activated receptors gamma agonist Rosiglita sone didn't present the antitumor impact in advanced myxoid liposarcoma patients, Right up until currently, 9 dif ferent kinds of FUS DDIT3 fusion genes have been described, involving predominantly the central and C terminal parts of the FUS gene and nearly normally the whole DDIT3 gene, We describe here for your first time a whole new fusion kind including the RNA binding domain from the FUS gene, which is not identified in the other fusion sorts except for variety 8.
This broad array of target cells has permitted us to reveal how Akt influ ences oncogenic phenotypic changes corresponding to your cell context in various degrees of malignancy. We have dis covered that Akt, in an isoform independent fashion, has tumor suppressive properties because it can inhibit of EMT, lessen cell motility, and lessen the stem progenitor cell population. These aberrations are rather prominent in non malignant epithelia but diminish as cells progress to a a lot more neoplastic state. Having said that, even in non malignant cells, Akt activation can have tumor advertising properties because it can encourage cell survival following exposure to chemother apeutic agents. Taken collectively, this examine denotes a novel paradigm that activated Akt signaling can have each tumor suppressing and tumor promoting properties.
Success Activated Akt signaling impedes EMT and attenuates cell migration in non selleck chemical malignant breast epithelia Our preceding report unveiled that, in non malignant breast epithelial cell line this kind of as MCF10A, Akt signaling can be activated by tumor microenvironmental stimuli pro voked from an exposure to breast cancer linked fibro blasts, Nonetheless, it remains rather controversial how Akt signaling impacts breast oncogenesis considering that information gener ated from animal versions is inconsistent with data from clinical research, regardless of the truth that several iso forms may possibly show distinct and opposing effects, Herein, we assessed the results of activated Akt signaling on neoplastic conduct in human breast epithelia. As breast cancer mortality is largely ascribed to meta static spread which is tightly linked to EMT and cell motility, the influence of Akt activation on these aberrations is of great interest. Hence, constitutive expression of Akt was engineered by transducing Myr Akt via retroviral delivery procedure into MCF10A cells.
Two weeks later on when maximal expression and Akt kinase exercise was reached, complete RNA was extracted from selleck chemicals the resultant cells and subjected to RT qPCR assays to quantify the expres sion amounts of the panel of known EMT transcripts, including the epithelium associated protein E cadherin as well because the mesenchymal linked proteins fibronectin, FOXC2, N cadherin, Twist, and Vimentin, Interestingly adequate, regardless of isoform styles, activated Akt signaling consistently yielded a discover ready induction of E cad along with an inhibition of different mesenchymal connected transcripts, Western blotting confirmed the modifications in mRNA amounts may also be noticed on the protein degree, This observed suppression of EMT is mirrored by a moderate lessen in cell motility, as measured by using transwell migration and wound healing scratch assays, In these experiments, activation of both Akt1 or Akt3 resulted in the higher than two fold inhibition of motility compared to vehicle controls, whereas activation of Akt2 resulted a much less prominent impact.
We have hence investigated the signaling pathways induced by SPARC to determine likely downstream therapeutic targets to particularly inhibit SPARC induced invasion, whilst most important taining SPARC mediated inhibition of proliferation.
We have now discovered that SPARC selleck inhibitor promotes glioma migra tion and invasion, in aspect, as a result of the upregulation from the p38 MAPK MAPKAPK2 HSP27 signaling axis, The tiny heat shock protein 27 con tributes to actin microfilament stabilization and reorga nization wanted for cell migration, These functions are dependent upon its phosphorylation standing, Certainly, we demonstrated that treatment of SPARC expressing glioma cells with HSP27 siRNA pre vented SPARC induced migration and invasion, Interestingly, SPARC also promotes glioma cell survi val below demanding conditions by upregulating AKT action, The activation of AKT is considered for being by the binding of SPARC to integrin beta 1 subu nit, and downstream activation of ILK, Activated ILK activates AKT, Without a doubt, suppression of SPARC is accompanied by decreased ILK activity, On top of that, HSP27 and AKT exist in complex with p38 MAPK and MAPKAPK2 within the cytoplasm, Activation of p38 MAPK benefits in the downstream acti vation of MAPKAPK2, which phosphorylates HSP27, pHSP27 can bind to AKT and act like a scaffold protein to permit the phosphorylation of AKT by MAP KAPK2, leading to enhanced tumor cell survival signaling by mTOR activation and downstream suppres sion of autophagy, As SPARC can possibly professional mote AKT survival signaling through ILK and or HSP27, we hypothesized that HSP27 may possibly serve as being a downstream target, not just to inhibit SPARC induced migration and invasion, but in addition to reduce SPARC induced tumor cell survival signaling by means of AKT activation.
HSP27 also plays a significant role in inhibiting extrinsic and intrinsic cell death pathways. It inhibits the extrinsic apoptotic signaling pathway by stopping DAAX mediated signaling, and might protect against extrinsic and intrinsic pathways by inhibiting the translocation of professional apoptotic tBID onto the mitochondrial membrane, In addition, it could inhibit intrinsic apoptotic signaling by binding to cytosolic cytochrome C and thereby stop the formation RS-127445 in the apoptosome and caspase 9 activa tion, By interfering with caspase three activation, it indirectly also limits caspase seven activation, Therefore, the inhibition of HSP27 is anticipated to advertise apopto tic signaling, likewise as inhibit SPARC induced tumor cell survival signaling. Consequently, the objectives of this research had been to deter mine 1 no matter whether SPARC sensitized glioma cells to radia tion or chemotherapy, two no matter if focusing on SPARC decreased tumor cell survival, 3 whether or not HSP27 inhibi tion was a greater target to suppress SPARC induced glioma cell survival, and 4 figure out no matter whether HSP27 inhibition suppressed SPARC induced AKT activation and survival.
We have now consequently investigated the signaling pathways induced by SPARC to recognize likely downstream therapeutic targets to specifically inhibit SPARC induced invasion, though most important taining SPARC mediated inhibition of proliferation.
We now have discovered that SPARC selleck chemicals TGF-beta inhibitor promotes glioma migra tion and invasion, in aspect, by means of the upregulation in the p38 MAPK MAPKAPK2 HSP27 signaling axis, The small heat shock protein 27 con tributes to actin microfilament stabilization and reorga nization wanted for cell migration, These functions are dependent upon its phosphorylation status, Without a doubt, we demonstrated that treatment of SPARC expressing glioma cells with HSP27 siRNA pre vented SPARC induced migration and invasion, Interestingly, SPARC also promotes glioma cell survi val below nerve-racking disorders by upregulating AKT exercise, The activation of AKT is imagined to be by means of the binding of SPARC to integrin beta one subu nit, and downstream activation of ILK, Activated ILK activates AKT, Indeed, suppression of SPARC is accompanied by decreased ILK action, Additionally, HSP27 and AKT exist in complicated with p38 MAPK and MAPKAPK2 during the cytoplasm, Activation of p38 MAPK outcomes during the downstream acti vation of MAPKAPK2, which phosphorylates HSP27, pHSP27 can bind to AKT and act being a scaffold protein to allow the phosphorylation of AKT by MAP KAPK2, leading to enhanced tumor cell survival signaling by mTOR activation and downstream suppres sion of autophagy, As SPARC can potentially professional mote AKT survival signaling via ILK and or HSP27, we hypothesized that HSP27 could serve like a downstream target, not just to inhibit SPARC induced migration and invasion, but in addition to eliminate SPARC induced tumor cell survival signaling through AKT activation.
HSP27 also plays a significant part in inhibiting extrinsic and intrinsic cell death pathways. It inhibits the extrinsic apoptotic signaling pathway by avoiding DAAX mediated signaling, and can protect against extrinsic and intrinsic pathways by inhibiting the translocation of pro apoptotic tBID onto the mitochondrial membrane, Moreover, it could inhibit intrinsic apoptotic signaling by binding to cytosolic cytochrome C and thereby protect against the formation 3-Methyladenine of your apoptosome and caspase 9 activa tion, By interfering with caspase three activation, it indirectly also limits caspase 7 activation, Consequently, the inhibition of HSP27 is expected to promote apopto tic signaling, also as inhibit SPARC induced tumor cell survival signaling. Consequently, the goals of this review were to deter mine one whether SPARC sensitized glioma cells to radia tion or chemotherapy, two whether targeting SPARC decreased tumor cell survival, 3 whether HSP27 inhibi tion was a greater target to suppress SPARC induced glioma cell survival, and 4 ascertain regardless of whether HSP27 inhibition suppressed SPARC induced AKT activation and survival.
Discussion Treatment method of various MM lines with doses of Dox much reduced than LD50 concentrations resulted in phosphoryla tion of ERK1 and two, essentially the most abundant ERKs in mamma lian cells. As well as Dox, several other anti cancer medicines this kind of as paclitaxel and cisplatin induce activation of ERKs in different tumor varieties, Nonetheless, taxol inhibits ERK activation in numerous cell forms dependent upon experimental problems, In our review, Dox induced ERK1 2 activation protected MM cells from Dox induced cell death, as proven when MM lines had been pretreated using the MEK1 2 inhibitor, U0126, prior to Dox exposure, In support of our findings, it has been reported that, in many scenarios, ERK activation protects cells from drug induced cell death, though in some tumor cells, ERK activation contributes to cell death, These dif ferent results can be explained by distinctions in subcellular distribution of specific ERKs, the longevity of ERK signal ing, or phosphorylation of different substrates which might dictate death or survival, We studied 4 diverse MM lines for Dox responses just after ERK1 two manipulation either with an inhibitor or by shRNA approaches.
With the use of the ERK1 2 inhibitor, HMESO cells were the best responders as compared to MO and ME 26, A shRNA strategy to inhibit both ERK1 or ERK2 was studied in 2 MM lines, Of your two lines studied by this strategy, HMESO once more showed additional sensitivity to Dox induced killing selleck soon after ERK1 or ERK2 inhibition as compared to PPMMill, On top of that, in both cell lines, ERK2 inhibition was extra helpful than ERK1 inhibition in Dox induced cell killing, Though regulation of apoptotic pathways has become implicated in resistance of numerous cancers to chemother apy, we show that human MM lines endogenously more than express several prosurvival genes in comparison to nontransformed mesothelial cells.
The greater levels of those frequently upregulated genes, as reported by our lab and other individuals may well in part be responsible for drug resistance in MM cell lines. One example is, BCL2 and BCL xL antisense remedy facili tates apoptosis in mesothelioma cells, suggesting BCL2 BCL xL bispecific antisense remedy in combination with cisplatin or gecitabine may lead to a far more efficient treatment of MM, AP24534 Steady with our findings, ERK1 two activation is linked to expression and activation of BCL2 in numerous methods leading to an anti apoptotic or survival end result. cFOS, a protooncogene and element of activator protein 1, is upregu lated by crocidolite asbestos in rat pleural mesothelial cells, and endogenously upregulated in human mesothelioma cell lines and tumors, We show for your to start with time that BRCA1 and BRCA2 are endogenously overexpressed in MM cells, and are pursuing their muta tion and functional status in different MMs.


A pair of researchers, one with United Technologies Research Center, the other with IBM Research, has developed an algorithm that can be used to determine the longest straight-line path over water on Earth. In their paper uploaded to the arXiv preprint server, Rohan Chabukswar and Kushal Mukherjee describe their algorithm and what it revealed.
The two researchers created their algorithm in response to a post by an unknown person on Reddit (he has been identified as Patrick Anderson)—he posted what he claimed was the longest straight-line ocean trip possible on planet Earth. Along with the post was a graphic showing the proposed direct-line route, but no evidence of how it was found. Intrigued by the proposition, the two researchers wondered how they might actually calculate such a line. They knew that it would be possible to do it using a brute force approach, which would involve measuring the length of every stretch of ocean. But that, they noted, would likely require more computer power than they had. With a global map obtained from NOAA, which offered a resolution of 1.8 kilometers, they saw that a brute force approach would entail grinding through data describing over 230 billion great circles. And that would mean analyzing trillions of individual data points—clearly too much crunching for their available computer. To reduce the amount of work, they turned to mathematics—specifically, optimization algorithms called branch and bound. Such algorithms reduce the amount of searching by assigning routes to branches which themselves hold subsets of similar routes. As the algorithm runs, subsets are analyzed and branches eliminated, winnowing the amount of data requiring analysis until the branch that holds the solution is found.
By coding and running their algorithm and inputting the map data, the researchers found it took just ten minutes for their laptop to provide an answer. Interestingly, the answer was the same given by Anderson, who reportedly got his information from an unknown Wiki post. The line runs between a point on a shoreline in Pakistan all the way to a Russian shoreline—a distance of approximately 32,089.7 kilometers.


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American teenagers are more stressed out than ever - even more so than their parents, according to a new survey published by the American Psychological Association (APA) each year.
This year's annual survey found that nearly one-third of teens and adolescents consistently reported feeling depressed, sad and overwhelmed due to stress, especially stress from school, which they reported as far greater than what's healthy.
Indeed, the survey results showed that the average amount of stress reported by teenagers exceeded that which was reported by adults.
In addition to 30 percent of teens feeling depressed because of overwhelming stress, the APA's "Stress in America" survey found that another 36 percent reported feeling tired from it as well, with 23 percent saying they had even skipped meals as a result.
On a scale of 1 to 10, the average teenager reported the amount of stress they experience routinely was 5.8, compared with 5.1 for adults.
APA chief executive Norman B. Anderson said that the results of the survey are "alarming" as it pertains to teens feeling more stressed than adults. As a nation, he suggests that the "cycle of stress" needs to be broken, and that better support and education on stress management should be offered to help teenagers.
That's no surprise to counselors who work with teens on a frequent basis.
Steve Carlock, Director of HeartPointe Counseling in Sheridan, Indiana says that the demands of school, sports, work and other activities competing for a teenager's time make life stressful.
"Combined with social networking tools and the non-stop onslaught of media, which has become part of our computerized culture, and you have a perfect recipe for stress," said Carlock.
"Many of the teens I talk to come from broken homes where dysfunction was common, increasing the usual stressors they feel from competition at school," he added.
Such stressors include more rigorous school testing designed to prepare teens for future college and career plans – which, in some cases, start as soon as middle school.
Moreover, many teens reported an increase in stress levels over the last year, with 34 percent saying that they expected it would worsen during the coming year.


The regulation + guidance affecting fire doors is contained in Approved Document B, Volumes 1 + 2. These specifically cover fire safety guidance for buildings in which fire doors play a critical role in fire safety.
Note that this list is not exhaustive and other locations may require fire doors depending on the layout, use and fire plan of the individual dwelling.
The location and rating of fire doors will be based on the Fire Risk Assessment (FRA), design and layout of the particular building with consideration to the user's particular needs. The FRA must always be carried out by a competent, trained and qualified individual.
In the guidance documents a door which provides at least 30 minutes fire protection is designated FD30. A door which provides the same protection and also protects against cold smoke is designated FD30S. Similarly, a door which provides at least 60 minutes fire protection is designated FD60, or FD60S if the door also provides protection against cold smoke.
The Regulatory Reform (Fire Safety) Order 2005 also gives requirements for fire and smoke performance in certain buildings.
The Lorient solution is to fit a sealing system which, properly located and secured, prevents the passage of cold smoke, fire + hot smoke.


And I'll take 'em in a cast iron skillet any day!
Yup. That method usually gives a nice texture on the outside too.
Okay, on the meatloaf front, here's the big debate... red sauce or brown?
Gravy please. Everything can be made better with gravy. Even meatloaf.
but then there's creole sauce. They serve meatloaf with Creole sauce at Threadgills, here is the link to their meatloaf and their creole sauce recipe. The creole sauce is how I make it, and the critical issue with this recipe is the file' powder. I honestly don't think I'd bother making it without it. The meatloaf is good on it's own though, and once I was out of bacon and used chopped up panchetta on top and man it went over the top. good stuff.
I made the best hamburgers ever last week, nothing but chuck steak sauce and s&p. I think the cooking technique is key to good burgers. I don't care what you put in them for flavor..hell truffles couldn't save an overcooked hamburger.
I think it would work great with buffalo, which is often too dry to make a really great burger.
I am going to make hamburgers!
I am also first the first time going to grind them myself, so my first couple questions are what kind of beef to use and what is the best way to grind them?
I have both a food processor and a meat grinder.
All right folks. Peanut Butter Burgers. God given juiciness!
It was a lovely day to grill here. The temp in the backyard at 6:00 p.m. was still a little over 30C. Yes, I know it says 36C, but it was in the sun, so take off 5 or 6 degrees.
First you gotta get all the ingredients in the bowl. Salt, pepper, garlic powder, peanut butter, butter and some chopped shallots, ground sirloin or lean ground beef.
Form into patties and chill those suckers for at least two hours. More is always better.
Grill on med high heat. Turn after about 4 minutes. Note they are holding together nicely.
I like my hamburg buns grilled, Ryan does not.
There's no way I can get a picture to do justice to the juiciness of these babies. But then again, Ryan ate two, so they can't be all bad.
Oh did I mention I actually grilled these my own self? I'm starting to scare me.
What is this in real temperature? I know nothing of these numbers which you refer to.
There should be an international standard that we can all use.
I am making some fabulous burgers, from beef, the way that God intended, for a suprise (don't tell her) party for the lovely Mrs. Mayhaw, which will be occuring Saturday night in my big wreck of a house. 60 people, with kids (you bring em, you watch em). It should be fun. I am thinking that since I have already lost my mind, I might grind several kinds of beef and see what the variations are like. No buns though. I have no oven to put a bun into to.
Also, for your voyeuristic pleasure, I am going to make a meatloaf on the Weber. It's a pretty interesting process.
You are absolutely right. There should be an international standard! When will the US be joining the rest of the world?
Kristin, I was extremely happy with the chuck roast I got from Whole Paycheck last week. (I may be wrong, but I believe that the most recent recommendation for chuck that I've heard came from Alton Brown, who also said that ten pulses in the food processor ground the meat to the perfect texture.) I ground about 3 pounds with about 3/4 of a pound of fat for that 80/20 ratio, using my KitchenAid grinder, and added only some herbs and spices before forming the patties very gently.
Which brings us to another major philosophical issue. I'm very big on the gentle patty molding; I can see that Marlene is at the other end of the flesh manipulation range. What say y'all? Do you tenderly tuck the meat together, or do you mash the meat mercilessly??
There's a reason for that Chris. With the Peanut burgers you have to mold them firmly because there isn't a lot of binding to hold them otherwise. Mold firmly and chill, otherwise, they fall apart.
Makes sense. Still and all, I certainly know people who are firm about the need for a firm hand when making burgers. Of course, terrines are regularly ground fine and weighted. Just trying to find even more ways for people to disagree!
Ah, now when I make beer burgers, I don't mash them together so much.
Kristin, I was extremely happy with the chuck roast I got from Whole Paycheck last week.
You don't by chance know how to say chuck roast in Japanese....?
I guess it is time to sit down and learn my cow parts, anyone know a good site?
These sound good to me. turkey burgers with double smoked bacon.
We dont eat red meat( but yes, we do eat bacon) so I think I'll go with those.
I'll be using a mix of dark and white turkey. Check my blog for pictures of the turkey farm in my area.
Type "beef cuts" into Google and you will get lots of sites. The chuck is the shoulder.
There are quite a few sites with explanations of beef cuts but this one is pretty complete, with pictures of the cuts and explanations for each.
Alas, I have no photos to prove it. However, I do have confirmation that room temperature ground beef is utterly entropic, collapsing shortly after being placed onto a hot grill into shapeless clods of meat.
Those two sentences have a reverse causal relationship, btw.
I don't think I've ever thought about this. I usually grill them right out of the fridge.
So, sounds like you have to grill burgers again fairly soon so you can post some photos! As soon as it quits raining, burgers are on our menu.
I'm still pondering meat loaf and will probably be asking a mess of questions.
Well chilled is a key to good grilled burgers. Room temp just doesn't work. Next time we want photos Chris.
brother-in-law and sister-in-law coming down for dinner before the iron maiden concert. burgers, hot dogs, macaroni salad, german potato salad, saurerkraut with beer, etc.
80/20 beef, garlic powder, salt and white pepper, "cattleman's sauce".
john enjoyed the burger which was medium. grilled but then had to "better cook"(cook to grey and brown) the burgers for the bil and sil. they don't eat any meat that is pink/red.
though i did find some ground lamb in the freezer so next weekend i think it will be modified suvir's lamb burgers with tsziki and pita... will have to see.
I'm aghast: did no one make burgers this weekend?!?
Basically, you are looking for a "kata roosu."
But tonight might be the night for the meatloaf recipe I've been wanting to try for ages!
I'm having one of my worst work-weeks ever (and it's only monday.. ) and I've decided that Marlene's peanutbutterburgers will be just the thing to cheer me up this evening.
No burgers in the Jensen household...we grilled chicken skewers instead.
I really want to try the meatloaf challenge but I'm waiting to see how others are cooking the meatloaf on the grill. There is no way I'm going to turn my oven on in June!
Fall is but a whisper of the recent past--at least it is where I live in the upper reaches of Eastern, Washington. We had our first fluff of snow a week ago and a reasonable November storm is predicted for this weekend with temperatures holding at a chilly 18 degrees at night.
Along with the rumblings of cold winter weather and Holiday feasts, we turn our culinary musings to time-treasured, comfortable dishes. And so I invite you to join me in another kitchen adventure--the inimitable eG Cook-Off Series. In 2013, we've tackled the tricky cooking of Squid, Calamari and Octopus and we made delicious dishes out of the humble Summer Squash.
But today we're shunning all manner of counting calories, salt or fat content--for what is rich in flavor is good for the soul my dear friends. Please join me in crafting, nuturing and savoring a dish of Confit.


ENGLAND have signed up a sports psychologist in a bid to help their Under-21s avoid another tournament failure.
Rebecca Symes will fly to Poland next week with Aidy Boothroyd's side to help the Young Lions handle the pressure at Euro 2017.
England face Sweden, Slovakia and Poland in the group stages of the European Championships as they look to improve on their nightmare at the tournament two years.
Gareth Southgate's young guns finished bottom of their group with two defeats from three games.
And his successor Boothroyd says the key to improvement is in the mind.
ENGLAND UNDER-21S are getting ready for this summer's European Championships.
Boothroyd said: "Speaking to Gareth, we didn't think we had that support last time so we will be taking a sports psychologist with us.
"Her role is really to prepare the players to talk about what goes on inside their heads when we get to 'flight or fight or freeze' and just make sure we're aware of it in ourselves and others.
"I think the psychology of it all is the key, there's no doubt about that in my mind.
"You've got to get all the other bits right as well but you can be the most gifted player in the world and understand tactically what you're supposed to do but if you haven't got that little bit of confidence that makes the difference then you're not going to get that medal.
Symes has previously worked with Surrey's cricketers, England's top archers and Great Britain's Paralympics team.
Boothroyd said: "There's nothing about it that's unusual, it's just a group session talking about training, about why some players might lose their head a bit or go into that zone that might get them into trouble.


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Wisconsin assistant won't coach in 2019-20 after setback
MADISON, Wis. (AP) — Wisconsin says assistant coach Howard Moore, who survived a car wreck two months ago, won't coach during the upcoming season after experiencing a medical issue and going into cardiac arrest.
Moore suffered third-degree burns in a crash in May that killed his wife, Jennifer, and 9-year-old daughter, Jaidyn.
The school said Monday that Moore recently experienced a medical issue at his Madison-area home that required him to be transported to a hospital. While in transit, he went into cardiac arrest.
The school says Moore will be moved to a long-term care and rehabilitation facility.
The Chicago native played at Wisconsin from 1990-95 and was head coach at Illinois-Chicago before returning to his alma mater during the 2015-16 season.


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The Creaking Steamship That Launched Widespread Cholera Hysteria That Waylaid Michigan's Boy Governor in the Woods and Eventually Led to the Founding of the University of Michigan
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By evening, an Army doctor diagnosed two men on the Henry Clay with Asiatic cholera. The doctor immediately ran away, hiding in a local hotel. Panic took hold of the ship, then the city, and then the territory, in short order.
by Fritz Swanson
The Henry Clay, a side-wheel steamer that was already old in 1832, creaked into the port of Detroit and discharged a ship's hold of infantrymen from Virginia. The troops were garrisoned in Detroit as reserves in case Black Hawk's Native American rebellion over in Wisconsin wasn't successfully quashed. That afternoon, the soldiers mingled with civilians at General Lewis Cass' traditional Fourth of July barbecue.
As the July heat set in, black and bloated corpses were laid out in a dockside warehouse. All around the territory, fear had taken charge in place of government. The villages around the city erected blockades and posted armed sentries, in an effort to defend against cholera. But the primary consequence of this self-interested defense was that the roads needed to bring food and supplies to the city, and to fight the disease, were cut off. As the fragile reach of the territorial government collapsed, the acting governor of the Territory of Michigan realized he needed to ride out into the wilderness and reestablish order so that the epidemic could be fought successfully.
His name was Stevens T. Mason. He was just 20 years old.
And so, with his top hat jammed on his head, the long-legged young man in a flapping black cloak rode from town to town, commanding residents to burn down their barricades and assist their fellow citizens. Though he was arrested, shot at, and wrestled to the ground by panicked villagers, he calmed the local authorities, who in turn restored order to their towns and re-opened the roads from Niles to Jacksonburgh, and then on through Ann Arbor and into Detroit.
It was on this wild ride that Mason went lost beyond Marshall and wandered in the woods until he stumbled upon a rustic cabin. He was taken in by the Reverend Mr. John D. Pierce, who was then caring for his cholera-stricken wife, Millicent (Estabrook) Pierce. Mason discovered that Pierce (along with his friend Isaac E. Crary) had been developing ideas for a state-wide public education system based on the Prussian model. It was just the sort of system Mason had been imagining when he gave his first speech as acting governor, impressing upon listeners the importance of free public schooling.
Millicent Pierce died that night, and in the morning, the Reverend Pierce and Mason rode back to Detroit to minister to the sick. The epidemic subsided, and far fewer people had died than many had feared. Much of this can be attributed to Mason, who had brought order to the territory.
Soon, Mason would bring order to state-funded public education as well.
Religion, Morality, and Knowledge
The University of Michigan may have been loosely formed in 1817, but it took the work of Mason to turn those flimsy paper dreams into a brick reality.
In those days, all of the major universities in America were privately endowed and religiously sectarian. Even the few "public" universities, such as the University of Virginia, were not really creatures of the state, but instead gifts set up by a few wealthy men for the children of their class. Likewise, almost no primary or secondary schools were open to the public, and Mason was afraid that private academies would take hold in Michigan, as they had in his native Virginia.
After 1832, however, Mason's educational plans had to take a backseat to other Michigan matters, including a war with Ohio over Toledo. The city — plus a 468-square-mile strip of land along the Michigan-Ohio border — was lost as Mason pushed for statehood, but the mineral-rich Upper Peninsula was Michigan's consolation prize. For the trouble of the war, President Andrew Jackson fired Mason, but when statehood was achieved in 1837, the citizens of Michigan all remembered the many things their Boy Governor had done and returned Mason to his offices in Detroit as Michigan's first state governor.
This brought Mason to the apex of his career. It was from this vantage, and with the well-earned goodwill of the young state's citizenry, that the 26-year-old embarked on an ambitious plan of internal improvements, including the creation of the University of Michigan.
Illustration Courtesy of Bentley Historical Library
After 1832, however, Mason's educational plans had to take a backseat to other Michigan matters, including a war with Ohio over Toledo.
Four professorships were established at the annual salary of between $1,200 and $2,200. Mason and the regents had botanist Asa Gray, the first professor, travel to Europe with $5,000 in gold for the purchase of books. A 40-acre portion of the Rumsey-Nowland farm of Ann Arbor was purchased as a site for the future university. Mason's original University campus was set at the western edge of the farm (land now occupied by Angell Hall), a modest pair of four-story brick buildings, a northern structure known as "The Main Building" (the first home of LSA), and a southern structure known as "South College."
Fear Over Logic
Unfortunately, Mason's dreams for Michigan ran up against the reality of a financial panic sparked by a real estate bubble.
While the causes of the Panic of 1837, and the depression that followed, are the subject of heated debate, one theory places blame squarely with President Andrew Jackson.
Jackson, who had long distrusted frontier real estate schemers, demanded that all land transactions use gold and silver. He also paid off the national debt for the first (and only) time, and closed down the United States Bank in 1833. But with the radical departure of the federal government from the banking system, coupled with weak banking regulations and a new necessity for precious metals, people hoarded gold and silver, and the value of paper currency (which was being produced by unregulated "wildcat" banks that no longer had the backing of U.S. federal bonds) collapsed.
As with the cholera epidemic, fear triumphed over logic. And again, the old homesteaders turned away from government and looked after their own interests in order to survive.
In the face of the financial chaos, there had been little time to discover, let alone survey, the state lands set aside to finance Mason's University program. When the land was finally investigated, squatters occupied most of it, and those squatters were voters.
A squatter even occupied the 40-acre parcel in Ann Arbor, where the Main Building was being prepared for the future University. Mr. Pat Kelly had taken possession of the land and farmed it all the way through construction. No one had asked him to leave, and so he farmed what is now the Diag, while the half-completed edifice of LSA's future home towered serenely over his fields of corn.
Mason and Pierce's plan, which had been passed into law, called for the public school lands to be sold for $15 per acre, which the squatters had to buy from the government. But once the panic had set in, the Michigan legislature passed a law advancing a price their constituents, the squatters, deemed fair: $1.25 per acre. Mason vetoed the bill, and passed another that set the rate at $12, but the damage was done. The homesteaders who, in 1832, were grateful for a strong government that could protect them from cholera as it whipped across the territory were, five years later, not interested in paying for their stolen public land. The public finally turned against Mason.
Everyone agreed that solid infrastructure and a fully financed public education system were a communal good, but no one wanted to pay for any of it.
In 1840, Mason did not seek re-election.
One Ending, One Beginning
Governor Mason's political nemesis William Woodbridge ascended to the governorship and set about overturning as many of Mason's decisions as he could. He sold the public lands for $1.25 per acre, netting the University a meager endowment. When Asa Gray came back from Europe with his massive collection of books and botanical samples, Woodbridge fired him. (Gray went on to become one of history's greatest botanists and a friend of Charles Darwin, and he secured the U.S. publication of On the Origin of Species — all from his office at Harvard.) Finally, Woodbridge cut the salary of the state superintendent so drastically that the Reverend Pierce was forced to return to the ministry.
Woodbridge himself left for a Senate seat a year later, in 1842, and one of his successors, Governor John S. Barry, said of the meager campus where Pat Kelly had farmed, "Well, we've got the buildings…I don't think they're good for anything else, so we might as well declare the University open."
And so began the University of Michigan, one of the greatest universities in the world.
Mason died of pneumonia shortly thereafter, in January 1843, while studying for the bar exam in the state of New York. He was 31 years old.
The Main Building, the northern of Mason's two campus buildings, was given the name Mason Hall. Angell Hall grew up around it. The original Mason Hall was demolished, but a new building that bears his name stands there today, its moniker a mystery to most of the students who pass through its halls.
Fritz Swanson teaches in LSA's Department of English Language and Literature and is the founder of Poor Mojo's Almanac(k).
Sources: Peckham, Howard. The Making of the University of Michigan: 1817–1992 (University of Michigan Press, 1967). Sagendorph, Kent. Stevens Thomson Mason: Misunderstood Patriot (Dutton 1947) and Michigan: The Story of the University (Dutton, 1948).
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Tragic Sidebar
The Four Portraits of Stevens T. Mason
Governor Mason's large full-length oil portrait hangs in the office of the director of the Bentley Historical Library. A rapturous public donated large sums to pay artist Alvin Smith to paint the portrait, but at the same time they refused to pay sufficient salaries for positions like secretary of state or attorney general. The public lauded Mason as their hero, but denied him the resources to govern effectively. The painting itself seems intertwined with his undoing.
His other portraits don't fare so well either.
An English illustrator drew Mason's second portrait while the Boy Governor was being shaved at a barber. The artist later would sell the portrait as a true-to-life sketch of the poet Lord Byron. Today, the Michigan state archives owns the portrait.
Kerry Chartkoff, chair of the Michigan Save the Flags committee, tells the tale of the third portrait. In 1911 a bundle of "rags" was discovered in the basement of the Capitol. Inside was Michigan's first flag, lost since the Civil War. Chartkoff attributes the painted flag to artist Alvin Smith. "On one side was a full-ength portrait of Governor Mason himself. On the other was a portrait of General Hugh Brady, various other designs, and the coat-of-arms of the new state."
In 1912 the flag disappeared. The only remaining evidence of the flag was a photograph, taken in 1911 by Mason's first biographer, Lawton Hemans. The photograph was discovered when Mr. Hemans' home (in Mason, Michigan) was purchased by historian Loren Shattuck. Mr. Shattuck asked the Hemans family if they knew anything else about the house, and they sent him Hemans' photograph of the flag, along with many other pieces of Mason memorabilia.
Finally there is Mason's statue in Capitol Park in Detroit, which presides over his grave. Mason's sister brought his body to Detroit in 1905, but in 1955 the grave was moved to make way for a bus stop.
When the park was renovated in 2010, the grave was missing. The remains were finally found, by chance, four days later.
Sources: The Detroit News. www.nighttraintodetroit.com. www.michigan.org
Faculty; Alumni


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Glee Season 1 Ep. 16: Home – And Some People Just Fall In Love Again
From the performance packed tribute to Madonna episode, comes a heartwarming emotion filled episode that is "Home." The characters get in touch with their emotional side and fight different issues. Plus, the character of "Becky" is slowly building up, which is great as the show is open to special children as well. For more about this episode, read through this Glee Episode Review!
Spoiler Alert Spoiler Alert Spoiler Alert Spoiler Alert Spoiler Alert Spoiler Alert
As Kurt and Mercedes continue to become a member of the "in" club which is the Cheerios, Sue pressured them to lose weight so that they'll look better. Kurt is definitely not ready to give up being in the "in" club so he pressures Mercedes more. Now this poor girl is starving herself and woof! Fainted!
Meanwhile, Kurt's unending crush with Finn went to a higher level. He set up a meeting of his dad and Finn's mom in one of the parents' night. His purpose is that if their parents would hit it off, then he and Finn would be living together too! That's quite an idea, I should say. Although what he missed though is that his dad and Finn share the same interest – SPORTS! Kurt is a son of a former football player. Quite a toughie if you see him. And Kurt could not relate with him of course as Kurt is interested in other things. So now, Kurt's dilemma is that he's slowly getting left out. With his dad and Finn sharing the same interest, he feels he could not get his dad's attention anymore.
On the other hand, Finn is still not over his dad and he's a little apprehensive that his mom is dating again. Kurt's assured Finn that he'll never be able to replace his dad. But he loves Finn's mother so much and that he'll be there to take care of them.
Now, will found April again, managing a roller skates place. Very 80's ambiance but cute! April is a mistress of a wealthy businessman who is keeping her alive by providing her the dough. And to earn extra, she was given the roller place. Will is looking for a place or a new "home" for the Glee as Sue blocked off the auditorium for the Cheerios. April told him to bring the Glee to the roller place to practice.
Will is still going through his divorce and he's looking to sell his place. April is of course interested, first that Will is single and free to "mingle" – by mingle, I mean sleep and have sex with people – and second with his place. So she invited herself over for a slumber party in his place. She slept on the couch. She started to sing a mash up of "A House Is Not A Home" and "One Less Bell To Answer" that ended up as a duet with Will, reflecting both their heartaches and pains. They didn't do the deed, but shared the same emotions.
Meanwhile, Becky, the child with down syndrome who is a part of the Cheerios, is slowly building up her character. She's seen more often now and has speaking lines. I actually admire this as the children with special abilities are not left out. They actually need that feeling that they belong. Inclusion is still the way to go for the special children. The background on Becky is that Sue accepted her because she had a sister with down syndrome as well.
Quinn helped Mercedes and talked some sense into her that starving herself will not really do any good for her. Mercedes stood up in the pep rally and sang "Beautiful" to show her feelings about the way she looks. Everyone was impressed and joined the song. Sue was actually clueless. She was trying to set her best foot forward as a magazine writer was there to observe her and make a story. Now, she didn't know what to expect or to do anymore. But of course, things would turn out in favor of Sue. During her meeting with the writer, the writer said that his first impression with Sue was that she was a bossy and racist. But he was impressed with the turn out of the pep rally. Sue was speechless. She was given praises that she didn't really deserve. Her face looked a little guilty. It's good to know that some things get through Sue's strong personality.
Will didn't want to make a habit of "sleeping" with April. He talked to her and gave her some advice. Then April returned again and gave Will good news – that she is now on her way to cleaning her act up and be sober. Her boyfriend died and the wife left her a shining 2 million dollars to shut her up. She of course accepted and her first purchase? Mc Kinley High's Auditorium which is now called: April Rhodes Civic Pavilion. Glee is now back to their Home.
The Songs:
• Fire – a Bruce Springsteen original. Duet between April and Will in the roller place. They really have this cute chemistry when they sing.
• A House Is Not A Home – a Burt Bacharach original. Sang by Kurt in one of the Glee sessions, looking over at Finn, asking him to love… him!
• One Less Bell To Answer / A House Is Not A Home – both by Burt Bacharach. This mash up was sung as a duet by April and Will, showcasing their pains and feelings.
• Beautiful – a Christina Aguilera original. Mercedes sang beautifully, expressing her feeling about the way she looks and stood up for herself that she looks great! High five!
• Home – a Diana Ross original. April gave a powerful performance, yet again! Wearing a glamorous outfit, accentuated with shining, shimmering neck piece, she was a diva!
Click here for more of Becky in Glee.
Posted by Soraya Peralta
More info: Glee on Jack TV


One white metal miniature in 25mm/28mm scale.
This miniature is not supplied with bases and is supplied unpainted. Select your option on this page with the drop down menu one miniature or three saving 10% automatically. Assembly is required with some miniatures.


Where is the brand from?
Frescobol Carioca is a Brazilian brand inspired by Rio de Janeiro's active and effortlessly cool lifestyle.
Our line of wooden accessories is handcrafted in Brazil, and the prints on our trunks are inspired by the mosaic sidewalks of some of Brazil's most iconic beaches.
What fabric are the trunks made of? How many styles do you have?
Our trunks are crafted from a special Italian polyamide developed exclusively for us which is 20% thinner than any other swimwear fabric. We have two styles: Sports shorts and Tailored shorts, and they both come in a short and long length. Within these two styles there are many prints or block colour options to choose from.
On each product page you will find a link to the size chart - it is located on the right hand side below the product description. You can also find our Size Chart here. This will help you determine which size to select. If you require further help please contact us via chat, email or phone.
How many beach bats are in a set? How do you play this game?
The beach bat set includes: 2 bats, 2 balls and a protective navy pouch.
A neoprene case that fits both the bats and balls is also available to purchase, in three different colours.
Frescobol is a non-competitive game for 2 to 4 players. The goal is to keep the ball in the air for as long as possible.
How do you take care of your beach bats?
We choose our manufacturing partners carefully, based on the expertise they can provide to ensure a high standard of quality.
- Apparel is made in Portugal.
- Beach Bats; Skate and Surfboards as well as Hand-surfs are hand-crafted in Brazil.
You have 30 days from receiving your order to return the item.
- Place unwanted items back in the original packaging.
- Complete the returns form you received with your order and attach the pre-paid returns label onto your parcel. If you have lost Returns Form, you can easily download it here.
- Arrange a collection with DHL from your desired location, or drop it at your nearest Post-Office.
When the item is received back into the business it will be processed and refund or exchange given. You will be notified once the order has been received and refund / exchange has been processed.
Yes. You can find full Returns instructions here.


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Wringinanom is een bestuurslaag in het regentschap Situbondo van de provincie Oost-Java, Indonesië. Wringinanom telt 1937 inwoners (volkstelling 2010).

Plaats in Oost-Java


Pipe support brackets designed for helical piers and mounting on steel and concrete.
Pipe clamp systems designed for helical piers and mounting on steel and concrete.
Pipe support brackets & clamps custom designed for pipe sizes 2 to 48 inches. Various oil & gas applications and other mechanical piping systems.
TerraTek Field Services is a Pennsylvania-based company located in the Marcellus Shale gas deposit region, providing services to Eastern and Central United States.
The TerraTek team is experienced in helping the oil and gas industries, especially throughout the Marcellus Shale natural gas region.


I use the newest Sisuzlizer version 4.0 Build 370.
I try to localize a new WPF .net 4.6.1 project. But I got always the same error. For a simple test, I have created a default WPF project based on .net 4.6.1 with the same result.
On the sisulizer pc I have installed VS2017 with the build tools and the sdk 10A.
Also with compiled assemblies (debug and release) the errors are not solved.
09:16:27	Error	Could not compile XAML files.
Project "C:\Projects\WpfApp461\WpfApp461\WpfApp461.proj" on node 1 (Restore;ResolveReferences;MarkupCompilePass1;MarkupCompilePass2 target(s)).
Project file contains ToolsVersion="15.0". This toolset may be unknown or missing, in which case you may be able to resolve this by installing the appropriate version of MSBuild, or the build may have been forced to a particular ToolsVersion for policy reasons. Treating the project as if it had ToolsVersion="4.0". For more information, please see http://go.microsoft.com/fwlink/?LinkId=291333.
C:\Projects\WpfApp461\WpfApp461\WpfApp461.proj : error MSB4057: The target "Restore" does not exist in the project.
Done Building Project "C:\Projects\WpfApp461\WpfApp461\WpfApp461.proj" (Restore;ResolveReferences;MarkupCompilePass1;MarkupCompilePass2 target(s)) -- FAILED.
09:16:27	Note	Please send "C:\Projects\WpfApp461\WpfApp461\WpfApp461.zip" file to Sisulizer support team.
Thank you for files. We'll check this issue.
Restore target could not be found. This indicates that MsBuild cannot call NuGet. Does NuGet work on your Visual Studio?
Yes the nuget works fine in Visual Studio.
5) Build the project. Now Sisulizer writes detailed info to log.
That your for the report. I found out what caused this.
When compiling XAML files Sisulizer needs to use MsBuild of Visual Studio. In your report I saw that MsBuild of .NET framework was used. The reason was that you have 32-bit operating system. Sisulizer did not correctly read the path of VS from system registry if OS was 32-bit. I need to fix this. Unfortunately I don't have 32-bit VM with VS. Can you help me a bit?
HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\VisualStudio\SxS\VS7 and that contains 15.0 key.
If your machine C:\Program Files might be something else and Professional might be Enterprise.
I have attached a similar settings on 64-bit machine.
The registry key is identically as you have described.
Thanks. I fixed this. The fix will be in the next build (371). I also sent you a personal message.
This fix solves the problem.
Thank you for your fast support.


The Spanish-American War is often referred to as the first "media war." During the 1890s, journalism that sensationalized—and sometimes even manufactured—dramatic events was a powerful force that helped propel the United States into war with Spain. Led by newspaper owners William Randolph Hearst and Joseph Pulitzer, journalism of the 1890s used melodrama, romance, and hyperbole to sell millions of newspapers--a style that became known as yellow journalism.
The term yellow journalism came from a popular New York World comic called "Hogan's Alley," which featured a yellow-dressed character named the "the yellow kid." Determined to compete with Pulitzer's World in every way, rival New York Journal owner William Randolph Hearst copied Pulitzer's sensationalist style and even hired "Hogan's Alley" artist R.F. Outcault away from the World. In response, Pulitzer commissioned another cartoonist to create a second yellow kid. Soon, the sensationalist press of the 1890s became a competition between the "yellow kids," and the journalistic style was coined "yellow journalism."
Yellow journals like the New York Journal and the New York World relied on sensationalist headlines to sell newspapers. William Randolph Hearst understood that a war with Cuba would not only sell his papers, but also move him into a position of national prominence. From Cuba, Hearst's star reporters wrote stories designed to tug at the heartstrings of Americans. Horrific tales described the situation in Cuba--female prisoners, executions, valiant rebels fighting, and starving women and children figured in many of the stories that filled the newspapers. But it was the sinking of the battleship Maine in Havana Harbor that gave Hearst his big story--war. After the sinking of the Maine, the Hearst newspapers, with no evidence, unequivocally blamed the Spanish, and soon U.S. public opinion demanded intervention.
Today, historians point to the Spanish-American War as the first press-driven war. Although it may be an exaggeration to claim that Hearst and the other yellow journalists started the war, it is fair to say that the press fueled the public's passion for war. Without sensational headlines and stories about Cuban affairs, the mood for Cuban intervention may have been very different. At the dawn of the twentieth century, the United States emerged as a world power, and the U.S. press proved its influence.


Skinite Free download FLV to MP3 Converter i instalirajte ga.
1. Kliknite na "Add Files" i odaberite video iz kojeg zelite izvuci MP3 audio.
2. U output format odaberite MP3 (Audio only). Pod opcijom "Destination" , kiknite "Browse" i odaberite folder gdje zelite da vam se snimi vas MP3.
3. Kliknite start za konverziju FLV videa u MP3.
Eto, to vam je sva mudrost. Sada mozete imati vase omiljene hitove sa Youtubea u MP3 formatu, mozete ih sprzit na CD, stavit na mobitel ili slicno.
Excellent post. I used to be checking continuously this blog and I'm impressed! Extremely useful info specially the remaining phase :) I take care of such information a lot. I used to be seeking this particular info for a long time. Thank you and good luck.


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Q: On which versions of SQL Server can I use VARCHAR(MAX)? On which versions of SQL Server can I use VARCHAR(MAX)?
From experimentation I can't use it on 2000, but I can use it on 2008 R2, but where was it introduced in between these two versions?

A: AFAIK since SQL Server 2005 where NTEXT was deprecated and NVARCHAR goes in. More info here and here.
EDIT
Same goes to VARCHAR.

Microsoft introduced the VARCHAR(MAX),  NVARCHAR(MAX), and VARBINARY(MAX) data types in SQL Server 2005.

redpajama_set_name: RedPajamaStackExchange


text:
Back to Editorial
Try Programa for free, and start redesigning your future.
© Programa 2021. All rights reserved.
Killing Matt Woods
This Camperdown apartment for two design professionals was conceived of as an intimate, yet utilitarian environment.
Kat Liu
Inspired by Brutalism and the local warehouse vernacular, extruded geometries and moody tones result in a minimalist and precise interior. The project brief called for the re-design of an inner city warehouse conversion in Camperdown, for a couple seeking a minimalist lifestyle with an interior to match.
The project brief called for the re-design of an inner city warehouse conversion in Camperdown, for a couple seeking a minimalist lifestyle with an interior to match. The clients, who work in design-related disciplines, sought to shed their home of unimportant accumulation and create a space free of clutter and visual pollution. Conceived of as a "concrete bunker", the shell of the apartment has been informed by the designer's penchant for Brutalist architecture. The principal intent was the creation of a pared back, geometric interior and a celebration of the neighbourhood's industrial heritage.
The west-facing open plan apartment features a custom kitchen and a mezzanine bedroom which overlooks the living room space and small terrace. The loft is flooded with light from a full height, glazed wall, counterbalancing the interior mood, which is intentionally dark and brooding. All interior elements have been created as "raw and extruded concrete monoliths", as seen in the fluted kitchen joinery, curved ceiling forms and the cement-rendered bathroom. A homely "mid-century" touch has been introduced in the form of film-faced plywood and American Oak joinery, brass accents and statement lighting. The furniture selection features geometric forms and a muted palette, underscoring the overall concept.
This interior eschews the cliched "industrial" warehouse aesthetic and ubiquitous"Sydney" design approach (read: natural / sea side / light, bright and airy), offering a fresh, yet site-specific take on the warehouse conversion category. Great lengths were taken to synthesise client direction and the specificity of the brief with a bold design approach. As a result, dematerialisation is at the core of the concept, and all elements have been reduced to their bare essentials, resulting in a utilitarian, cave-like sanctuary that is also intimate, light-filled and homely. Each design decision has been rooted in a practice of sustainability, resulting in a materials palette that is environmentally responsible (eg VOC-free finishes, strict use of FSC timbers, reduced use of chrome and cement) paired with a construction process that was streamlined to minimise waste.
Given the project context of a residential warehouse conversion, it would have been a natural to emulate any of the well-articulated examples in the genre. However, the designer has chosen to ignore the whims of trend, opting for a unique approach that perfectly underscores the clients' vision. Design innovation is evident in the skillful reduction of the functional components into simple geometric forms that are evocative. In addition, although the brief was a concrete box – remarkably very little cement has been used in its creation. The "solid" concrete elements are Glass Reinforced Cement (GRC) – which has far less weight and cement than traditional concrete techniques – and the "concrete finish", has been achieved with a French Wash Porter's Paint. This interior offers a probing look at the level of creativity and execution that can be achieved within a particularly restrained and pragmatic design approach.
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© Programa 2021.
Design: Standard Projects


All we have an idea about renewable energy sources. We also know how important it is for us. 2019 is promises to be an exciting year for cleantech. an increasing number of countries, companies, and regions are embracing sustainable energy generation. Also, the landscape is rapidly evolving. So here are 6 renewable energy trends to watch in the coming years.
Energy storage has an important role in balancing power supply and demand. It is the key to tackling the intermittency issues of renewable energy. To get a steady and smooth power supply, they pair this renewable energy storage system which ensures. It will be smooth and steady even when weather conditions are not optimal for energy generation. In a renewable energy system, They use the battery to store. Their use is increasing on both the residential and grid-wide scale. They are making their use more viable and affordable. So these energy storage will improve. Now it is projected that storage will represent a core component of all new energy technologies. Which is moving into the future?
Microgrids are local energy grids. That can operate either autonomously or while connected to a larger traditional grid. They provide energy independence, efficiency, and protection during emergencies. They use the machine learning capabilities of artificial intelligence. So microgrid controllers allow for continuous adaption and improvement of operation. The new software is allowing for designs to be completed in a single day. So the deployment of a microgrid is becoming significantly quicker.
It is originally developed to record cryptocurrency transactions. This blockchain technology is being adapted for use in the energy market. It records transactions through a peer-to-peer network. The blockchain is an incorruptible digital ledger. There is a lack of centralization in the blockchain, which leaves it as a deal for eliminating the middlemen of the electricity suppliers. It reduces inequality and inefficiency. This empowers consumers to buy and sell energy from other consumers directly.
They are now pairing the distributed ledger technology of blockchain with everyday devices. So we can use it to receive and convey information. Now commonly referred to as the Internet of Things. This stands to have a profound impact on energy systems.
Grid parity occurs when alternative energy can generate power at a cost. So the performance level is equal to or less than electricity generated from conventional methods. Solar and wind have reached parity in both prices. The performance in many regions and new technologies continue to hone their competitive edge. In the traditional model of large, top-down and centrally distributed, energy production is replaced by modular. Consumer-driven and evenly distributed power generation.
The number of corporations, cities, and countries is increasing. They are emissions reduction targets and climate actions are going to meet the goal of limiting the rise in global temperature. Over the 100 cities worldwide report that at least, 70 percent of their energy production is from renewables. More than 40 percent are operating on 100 percent renewable electricity. Hundreds more have worked towards the goal of energy generation and that is 100 percent based on renewables. They recognized the impact on climate change. So 158 companies have committed to transitioning to 100 percent renewables.
When we are talking about exciting new innovations in energy technology, the significant percentage of the world`s population remains without access to energy at all. A billion people live without electricity and hundreds of millions have expensive energy sources.


text:
<?php

use yii\db\Schema;
use yii\db\Migration;

class m151105_184316_video extends Migration
{
    public function up()
    {
        $this->execute('ALTER TABLE galaxysss_5.rod_article_list ADD video VARCHAR(255) NULL;');
    }

    public function down()
    {
        echo "m151105_184316_video cannot be reverted.\n";

        return false;
    }

    /*
    // Use safeUp/safeDown to run migration code within a transaction
    public function safeUp()
    {
    }

    public function safeDown()
    {
    }
    */
}

redpajama_set_name: RedPajamaGithub


Pocket Vocabulary contains English, Chinese, French, German, Spanish, Italian Vocabulary. It gives a list of categories that most commonly used in daily life with voice support. It has build-in translator so that you can add any words you like. You can also edit the vocabulary.
For example, if you are learning Spanish, it gives the word you need in the most commonly used in life. It also speak spanish so that you can learn how to pronounce the spanish word.
It has many other features that help you to learn different languages in very short time. It will be very useful while traveling. It serves as reference vocabulary also a quick way to learn foreign languages in one Pocket.


10 years ago, Facebook had just launched and the iPhone didn't even exist. Can you imagine a world without them now?
Tech companies don't rest on their laurels, though; they keep looking forward. Here are 5 technologies that'll change the world over the next 10 years!
Drones were one of the most popular Christmas gifts of 2014, with hundreds of people asking Santa for their very own flying personal servant.
Love them or loathe them, there's no doubt that drones will be a big part of the wonderful future. Imagine being able to drop something off without having to leave your house, or not having to hold a ridiculous stick to take a selfie!
Unfortunately, there are a couple of things holding back the drone revolution. The first is the law: it's illegal to fly a drone beyond your line of sight, and you aren't allowed to fly one within 50m of any person, building or vehicle either.
The second is that a lot of drone owners don't actually know how to control them. Without proper drone training for owners, the future will be full of crashing drones falling from the sky – and a lot of admissions to A&E!
With mandatory drone licenses and a few law changes, though, we'll be all set.
In 10 years, you'll be able to visit space and travel back in time without having to leave your living room – and its all thanks to virtual reality.
Virtual reality headsets – the most renowned of which is the Oculus Rift – could well change the world as we know it. They create immersive environments that appear to be 'real'. While you can't touch anything, you can look around and explore using a controller.
Gaming is the main application at the moment, although there is the potential to 'meet' with friends in virtual bars (there's a reason Facebook bought OculusVR for $2billion!), conduct meetings and even revisit historical events as if you were there!
The Oculus Rift should be released next year, although it'll be expensive (sell your smartphone if you can't wait). Give it a few years, though, and the technology should be readily available.
If you thought losing your TV remote was bad, wait until you lose the remote that controls everything in your house.
'Smart homes', in which everything you own is connected to the internet and automated, are already a reality but should become more common over the next 10 years. You'll be able to control temperature, automate your home entertainment system and even get your coffee machine going from the comfort of your bed with a single remote. Best not lose it, eh?
Even though there are loads of smartwatches on the market already, it's still a bit of a novelty to see someone wearing one. They haven't taken off like smartphones, and there's one reason for that: no-one knows what they're for.
At the moment, they essentially save you the hassle of having to take your phone out of your pocket and do a bit of fitness tracking. Eventually, though, someone will find a 'killer app' and smartwatches will be everywhere. We reckon it'll be the ability to link your watch to your phone from long distances (meaning you can leave your phone at home), but who knows?
Apple and Google have already launched their mobile pay offerings but, like smartwatches, they're still a novelty; It's rare to see anyone whipping out their iPhone at the checkout.
Luckily, the tech giants have a plan to get us using mobile pay more often: they're going to take our wallets and purses away. Soon, everything you keep in your wallet will be on your phone including your driving license, public transport tickets and store cards.
Which future piece of tech are you looking forward to most? Let us know in the comments!
And if you enjoyed this article, please share it on Facebook or Twitter – it's as easy as clicking the buttons above the post!