SALT LAKE CITY (AP) — Salt Lake City on Wednesday became the first U.S. city to announce its intentions to bid for the 2030 Winter Olympics as this year's games get ready to kick off in South Korea.
The city's Olympic exploratory committee concluded that Utah could host the Winter Games again without losing money thanks to existing venues and the budget expertise of a team that put on the 2002 Olympics.
The committee's 140-page report, which includes a budget estimate of $1.35 billion, will be sent to the U.S. Olympic Committee and the International Olympic Committee, said Fraser Bullock, Utah panel co-chairman. Bullock will be in Pyeongchang this month and plans to meet with officials.
Utah's bid would focus on Salt Lake City being a reliable, experienced Olympic city that could host at a lower cost than other places, which state officials believe aligns with the IOC's "Agenda 2020" blueprint for future Olympics. It calls for fewer billion-dollar projects and more venues already in place.
"It's a reminder of a period of corruption at the IOC, which they'd like to forget," he said.
"The report affirms what we've always kind of believed: That we are in a tremendous position to host the Winter Olympics again," Gov. Gary Herbert told reporters Wednesday.
The 2030 Winter Olympics wouldn't normally be awarded until 2023, but Salt Lake City prepared years in advance in anticipation of a possible dual award by the IOC next year for 2026 and 2030, said Bullock.
That's what the IOC did for the first time last year, scrapping its traditional rules and awarding the 2024 Summer Olympics to Paris and the 2028 Summer Olympics to Los Angeles.
It's not clear yet if the U.S. Olympic Committee will pick a U.S. city for the 2026 games, a decision expected by the end of March. USOC chief executive Scott Blackmun said officials believe 2030 is more realistic for the U.S.
Andrew Zimbalist, an economist at Smith College in Massachusetts, said Salt Lake City's $1.35 billion cost estimate seems low. He said it's not uncommon for cities to try to garner early political support by lowballing estimates.
The city faces several hurdles, including that LA is hosting the 2028 Summer Olympics, Zimbalist said. The same country hasn't hosted back-to-back Olympics since the U.S. in the early 1980s.
Anti-American sentiment at the IOC also has deepened under Donald Trump's presidency, Zimbalist said.
Bullock said LA overcame it and he's confident Salt Lake City can, too, noting that people worldwide recognize that Trump will be "long gone" by 2026 or 2030.


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Good vibrations on budget talks buoy the markets
by Steve Rothwell, Associated Press, Posted: December 18, 2012
NEW YORK - Stocks rose Monday as investors were encouraged by signs of progress in budget talks in Washington. Just two weeks remain before tax increases and spending cuts take effect if no deal is reached.
The Dow Jones industrial average rose 100.38 points to 13,235.39, its biggest gain this month. The Standard & Poor's 500 index climbed 16.78 points to 1,430.36, and the Nasdaq composite index rose 39.27 points to 3,010.60.
Marc Chaikin, chief executive officer of the Philadelphia-based market-research firm Chaikin Analytics, said investors became more hopeful for a resolution in the budget talks after House Speaker John A. Boehner made an offer to increase tax rates on high-income Americans.
"The fiscal cliff is obviously foremost on everyone's mind," Chaikin said.
Banks were among the best-performing stocks. Citigroup gained $1.55, 4.1 percent, to $39.15 after Raymond James raised its target price on the stock to $52 from $44. In a note to clients, the brokerage reaffirmed its "strong buy" rating, citing the "improving fundamental outlook."
Bank of America also gained 42 cents, or 4 percent, to $11.
Investors currently favor financial stocks over tech stocks, said Ben Schwarz, chief market strategist at Lightspeed Financial. "The banks are ripping today," he said. "People are looking for stability, and the tech sector hasn't given them any."
Financial companies make up the best-performing industry group in the S&P 500 this year, according to FactSet data. The group, which includes banks and insurers, has gained 25 percent this year.
Apple rose $9.04, or 1.8 percent, to $518.83 after the company said it sold more than two million iPhone 5s in China in their first three days of availability, a record for that market. The technology giant's stock has fallen 26 percent since it closed at a record $702.10 in September and is trading close to its lowest since February.
American International Group rose $1.01, or 3 percent, to $34.95 after the insurer said it was selling its remaining stake in the life insurer AIA Group. The Wall Street Journal said AIG might raise as much as $6.5 billion from the sale. AIG avoided collapse in 2008 with $182 billion from the government after suffering massive losses from investments in derivatives.
Tenet Healthcare gained 55 cents, or 1.8 percent, to $31.38 after Deutsche Bank raised its recommendation to buy from hold, citing Tenet's "compelling" business and financial outlook over the next one to two years.
Steve Rothwell, Associated Press
'America 250' birthday planners seek local projects, national funds
Joseph N. DiStefano
Philadelphia Defender Association refuses to recognize public defenders union — for now
Juliana Feliciano Reyes
Philly refinery auction said to attract Chicago developer that rehabs industrial properties
Remember that $8 billion Risperdal verdict? A Philly judge has drastically slashed it
Christian Hetrick
Giant Food to take the South Philly site initially planned for German grocer Lidl
Jacob Adelman

redpajama_set_name: RedPajamaCommonCrawl


Our Danby Air Purifiers Buyers Guide is here to help clear the air. Read on to learn more about how they can help you breathe easy!
We take 24,000 breaths a day and breathe in about 13 kg of air. Though occasional hazards like smog and visible air pollution catches our attention, the issue of everyday indoor air quality often goes unnoticed –especially indoors at our homes or places of work. Few realize that indoor air can be 2-5 times more polluted than outdoor air.
Also, today's energy-efficient homes tend to be air tight ,staying warm during the winter and cool during the summer. Unfortunately , the house isn't allowed to breathe and open windows are not always a good option.
Bacteria and viruses cause infections and worsen allergies. Pet dander can cause allergies leading to rhinitis or asthma.
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USPS wishes to update designated operators of UPU member countries on the status of USPS operations in Puerto Rico and the U.S. Virgin Islands in the aftermath of Hurricane Maria.
Thanks to the heroic efforts of many, mail service continues to increase across Puerto Rico and the Virgin Islands. As mail arrives from the U.S. mainland and is transported and processed across the islands, postal employees are out in full force providing customers with mail and retail services in postal facilities that were not significantly damaged by Hurricane Maria. Where offices are damaged, nearby locations have been designated for customers to pick up mail. Carriers have begun to deliver where it is safe to do so.
Electrical power has not been fully restored, and operations continue to be affected. USPS will provide additional updates when available.


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Art on the Cutting Edge – A Guide to Contemporary Movements
View cart "Movements in Modern Art: Postmodernism" has been added to your cart.
This book by Lea Vergine, which discusses seventeen different art movements in separate chapters, offers, within the panorama of contemporary art criticism books, a blend between a handy art-history manual and an assessment of a cultural adventure that has passed through and overturned the parameters of taste of the last forty years.
Art on the Cutting Edge - A Guide to Contemporary Movements quantity
SKU: 9788881187393 Categories: Art Theory and Reference, How To Books and Art References, International Art Tags: Art History, Education
The concept of the beautiful has undergone profound changes during the last half of the twentieth century, as has our way of considering everything that is called art. We need a new key to help us "know how to see" so that we can stay attuned to what is going on in the contemporary world of art where new aesthetic styles are appearing and being challenged one after the other.
This book by Lea Vergine, which discusses seventeen different art movements in separate chapters, offers, within the panorama of contemporary art criticism books, a blend between a handy art-history manual and an assessment of a cultural adventure that has passed through and overturned the parameters of taste of the last forty years. The clear and incisive writing style guides the reader, student or specialist, whatever his or her specific interests and curiosities, like an essential travel kit for understanding today's reality, grasping its raison d'etre, and above all, plunging into its multiple mutations.
Skira Publishing
Softcover, 21x15cm, 304pp,
Movements in Modern Art: Realism
Realist art of the twentieth century is striking for its diversity. It has no shared style or manifesto of intention. Yet a common thread in realist art is a commitment to the modern world and to things as they are. This book examines realism in Europe and America, beginning with its roots in the ideas of Gustave Courbet in nineteenth-century France.
Vitamin P2: New Perspectives in Painting
The first volume of Vitamin P, published in 2002, inaugurated a vibrant period for painting. Since its publication, a whole new generation of painters has emerged, some inspired by the artists who appeared in that book, others taking cues from new sources. Vitamin P2 introduces this new wave of painters to the world.
Movements in Modern Art: Cubism
Cubism, perhaps the seminal movement for the arts of the twentieth century, was also one of the most complex. Divided between the annual public exhibition and the emerging network of private galleries, between French and immigrant artists, it was
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Passport processing takes in excess of 3 to 4 months. Please note that if any of your parents were not born in Zimbabwe, a letter of citizenship renunciation from an Embassy/High Commission of the country concerned, must accompany your application.... Overseas Passport Application (PC8) If you are applying for a passport for a child, or if you are an adult and are not eligible to use the PC7 form, you must use the PC8 form.
The non-lodging parent should then take the consent form and valid form of ID and visit the nearest State Passport Office or Australia Postal outlet which provides passport services. If there has been a name change, this must also be documented by presented original documentatation in English.
Passport processing takes in excess of 3 to 4 months. Please note that if any of your parents were not born in Zimbabwe, a letter of citizenship renunciation from an Embassy/High Commission of the country concerned, must accompany your application.
collect an application form from an Australian mission in Japan Child passport applications If you are an Australian citizen under 18 years of age who is applying for an Australian passport in Japan, you are required to complete a full Application for an Australian Passport Overseas.


text:
Q: Can't update, can't install from SC 18.04 I have no idea what is going on, what to check or even where to search for help other than here. The past 5 updates have all frozen at around 75% complete, and I'm trying to install Gnome Calculator and it's stuck at 99%. All other software in the past 2 weeks has failed to install too.

A: Ran sudo apt-get update and it went flawlessly, I was then offered a partial upgrade which also went flawlessly and software is now installing. I can't believe it was that simple, I feel so silly. But thanks for helping.

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text:
Are Schools More Dangerous for Children Now? The Stats Might Surprise You
A lot of hyperbole is being thrown around that schools are more dangerous for our children than ever before.
As we struggle as a nation to once again find answers to the disturbing and horrific trend of mass school shootings, a lot of hyperbole is being thrown around that schools are more dangerous for our children than ever before.
"It's been happening everywhere," said a very shaken Paige Curry, interviewed by the media shortly after the shooting at her high school in Santa Fe, Texas on Friday. "I was thinking it was going to happen eventually."
This statement shook many concerned parents and citizens to their core: are our children expecting to be killed at school now?
It is easy to understand why Ms. Curry thinks this way, considering the way we as a nation react to school shootings. We understandably tend to stop everything and focus on the horrific crime, wondering how on earth we could let this continue to happen.
While the images of a heartbroken community paying homage to the young victims of the latest shooting is evocative and tragic, and we certainly need to address the root cause of these shootings as a nation, their prevalence is not necessarily indicative of an overall trend, The Washington Times reports.
While Secretary of Education under Obama, Arne Duncan, dramatically suggested this week a nationwide boycott of schools until "common sense gun reform" is passed, statistics show this isn't necessarily the best approach to keeping children safe from homicide.
"If safety is the goal, then keeping children in school is likely better than the boycott Mr. Duncan is proposing," The Washington Times' David Sherfinski explains. "The National Center for Education Statistics, looking at numbers from the 2014-2015 school year, found that less than 2 percent of homicides involving school-age children occurred at school."
"From 1992 to 2015, the total was less than 3 percent, the center found," he continues, adding "Children spend more than 13 percent of their time at school."
The narrative on the left, is, of course, rife with misperceptions about just how unsafe schools are in the wake of a trend of mass school shootings. Simple common sense dictates that, as tragic as it is, less than two dozen students and teachers killed in a handful of annual incidents does not in any way indicate our schoolchildren are at serious risk of being killed in a mass shooting on their school campus.
In fact, The Washington Post reports, "the statistical likelihood of any given public school student being killed by a gun, in school, on any given day since 1999 was roughly 1 in 614,000,000. And since the 1990s, shootings at schools have been getting less common."
So perhaps rather than rely on dramatic, fear-mongering rhetoric, we need to look at the deeper reasons behind school shootings and a culture of death and violence that drives these young men to commit these acts. However rare, it's hard to imagine school shootings will end any time soon, and however safe our schools already are, securing them further would be a very good place to start.
Related Topics:Featuredgun controlschool safetyschool shootings
The WNBA and Planned Parenthood Team Up to "Take a Stand" Against Trump
Media Mocks Texas Lt. Gov for His Comments on School Shootings. Here's Why He's Right.
A Dark Winter
A Political Cartoon By A.F. Branco Exclusively for Flag and Cross ©2020
A.F. Branco
A Political Cartoon By A.F. Branco Exclusively for Flag and Cross ©2020 See more A.F. Branco cartoons on his website Comically Incorrect.


This model is of very solid construction, the body is press formed and welded using 10mm thick steel. The safe accommodates A4 size documents, and has a removable shelf. There are four x 14mm holes in the base for anchoring. Bar locking and relocking features are standard. Optional extras include additional mounting holes, extra key lock, deposit slot with internal anti-fish baffle, and time delay locks.


The Comprehensive Perl Archive Network (CPAN) currently has 159,242 Perl modules in 33,073 distributions, written by 12,530 authors, mirrored on 233 servers.
© 1995-2010 Jarkko Hietaniemi. © 2011-2013 Perl.org. All rights reserved. Disclaimer.


I made this drink last weekend first with my hubby, Mr. Walters, before subjecting the Zesties to it. After sending S & C a picture post work-from-home-day it was requested to be featured and now we have decided to claim it as an original, it's probably not so ssshhhhhhh.
Ah so many fabulous puns we're exclaimed through the making of this drink as we tried to find a name suited for this creamy deliciousness. The top candidates for a proper name were the strung out sailor, the foaming pirate, the buzzed mate, and the minty mate, but ultimately the frothy shipwreck won! We sailed away into the afternoon as we lounged in the sun…oops…I mean as we continued sanding down some 2×4's :). Pirate themed or not these cocktails are suited for a jolly good time! Check out the recipe below!
Start by gathering all of your ingredients, including snazzy glasses and begin scooping! Also, for a lactose free alternative I recommend using Luna & Larry's Coconut Milk Ice Cream!
Next add in a tablespoon of vanilla extract into each drink.
Then add in your rum to achieved desired jolly-ness.
Next pour in your coffee we used hot coffee for this recipe, but I would recommend using iced coffee. Add approximately 4 oz into each glass.
Finally add your garnish, cute straws and you're set!
PS: We are all off at Knot Crashers today!!! Can't wait to update you all with pictures next week!


Load you VISA card on your phone and use the "Apple Pay" app on your phone to pay at most merchants with your phone. Its as easy as downloading the app and more secure than using your card.
Apple Pay: Which devices currently work with it?
Apple Pay works with iPhone 6 or iPhone 6 Plus and later (Apple Pay in stores and within apps), iPad Pro, iPad Air 2, or iPad mini 3 and later (Apple Pay within apps), and Apple Watch Series 1 or later (when paired with iPhone 5 or later).
Apple Pay supports most major credit and debit cards providers including Visa, MasterCard and Amercian Express. Apple Pay works anywhere that accepts contactless payments, which includes over a million stores. Just look for the contactless payments symbol near readers at checkout.
You need to use Apple's Wallet app to setup Apple Pay, or rather store your credit cards and debit cards. Apple Pay pulls this data to pay for goods.
On your iPhone, open Wallet. On your iPad, go to Settings > Wallet & Apple Pay. Tap Add Credit or Debit Card. If your card is already on file with iTunes, enter the card's security code. Otherwise, you can use your device's camera to capture the information on your credit, debit, or store card. Then fill in any additional information needed.
Your bank will verify your information. You may need to provide additional verification which can mean you have to phone your bank. After your card is verified, tap Next, and then you can start using Apple Pay.
To pay at checkout, just hold your iPhone near a contactless reader with your finger on Touch ID. You won't have to look at your iPhone's screen, because a subtle vibration and beep will confirm that you paid correctly. There's also no need to open an app or wake your iPhone's display.
Your fingerprint confirms the payment, or you could enter a passcode if you haven't setup Touch ID.
On the iPhone X, press the sleep/wake button twice to invoke Apple Pay. Face ID will check it's you, or the handset will ask you to enter your passcode if your face isn't recognized.
Once approved, a receipt is recorded in the Wallet app so you can see what you've purchased.


We're excited to release a new video that we recently produced! It highlights some of the wonderful features of our most popular mattress, our Botanical Bliss organic latex mattress. We hope the message that comes through is how much attention we put into manufacturing the safest, cleanest, and best latex mattress available!


text:
News Political News
7 Stocks That Can Win The Trade Wars: Goldman
By Mark Kolakowski
Trade tensions are dominating the headlines and providing an increasing source of worry for investors. If President Trump follows through on recent threats, new tariffs eventually will be imposed on $781 billion worth of U.S. imports, representing 27% of the total, Goldman Sachs reports. Given the likelihood of retaliation by countries whose exports to the U.S. are being targeted, Goldman suggests that investors look to U.S. companies that derive close to 100% of their sales domestically. This is the first of two stories that Investopedia will devote to this report.
Among the 50 stocks in Goldman's Domestic Sales basket are these seven, in the transportation, steel, technology and banking industries:
Stock Ticker Non-U.S. Sales Gain Since May 31
CSX Corp. CSX 0% 8.2%
Fiserv Inc. FISV 5% 6.7%
J.B. Hunt Transport Services Inc. JBHT 0% (4.6%)
Norfolk Southern Corp. NSC 0% 8.1%
Nucor Corp. NUE 0% 7.2%
Paychex Inc. PAYX 0% 8.5%
SunTrust Banks Inc. STI 0% 7.6%
Sources: Goldman Sachs U.S. Weekly Kickstart report dated July 20; gains are computed through the July 24 open using adjusted close data from Yahoo Finance.
By comparison, the S&P 500 Index (SPX) is up by 4.3% over the same period. While J.B. Hunt has lagged the S&P 500 since May 31, it nonetheless has outperformed on a year-to-date basis, 6.8% versus 5.5%.
Drivers of Outperformance
Goldman indicates that from the end of May through July 19, their full Domestic Sales basket has outperformed the S&P 500 by 130 basis points. They write that this group of stocks is "benefiting from a stronger U.S. dollar and above-trend U.S. economic growth, and is relatively insulated from trade risk." Moreover, they add that the basket offers an attractive valuation, with a forward P/E ratio of 17.8 times projected earnings over the next 12 months, versus 17.1 times projected earnings for the S&P 500 as a whole.
Remaining Risks
The stocks in Goldman's Domestic Sales basket theoretically face little or no direct risk from retaliatory tariffs, import restrictions or consumer boycotts abroad. However, some may suffer indirect impacts, to the extent that they sell to other companies whose own exports decline as a result of trade conflicts, a matter not remarked upon by Goldman.
Meanwhile, Goldman notes that tariffs imposed by the U.S. will increase costs for U.S. companies, and thus reduce profit margins. Overall, they estimate that imports account for roughly 30% of the cost of goods sold (COGS) incurred by the S&P 500. They add that transportation companies are among those industry sectors with the highest share of imported COGS. This could be an issue for railroads CSX and Norfolk Southern, as well as for trucking firm J.B. Hunt.
CSX, per Seeking Alpha, is already the most cost-efficient railroad operator, yet it continues to make improvements. As a result, its operating profit margin has been trending upward in recent years, moving above 34% in the first quarter of 2018. Meanwhile, a solid business environment in its service area is driving increased shipment volumes. Zacks Equity Research indicates that a system designed to increase operational efficiency yielded cost savings of $460 million in 2017, and that the company is targeting an operating ratio of 60% by 2020, which implies an operating profit margin of 40%. Zacks adds that CSX is in the midst of a $5 billion share repurchase program running through the first quarter of 2019.
Paychex is a leading provider of services related to payrolls and other human resources functions, and should benefit from an increasing trend towards outsourcing, per another Zacks report. Moreover, Zacks adds, the company has a very strong balance sheet, with no long-term debt and $424 million worth of cash equivalents and corporate investments. This leaves it well-positioned to make strategic investments and acquisitions. Per MarketWatch, consensus estimates call for 9% EPS growth in fiscal 2019, while the company expects 11% growth versus fiscal 2018.
Top 4 Transportation Mutual Funds
How Would a Trade War Affect You
8 Quality Stocks To Buy After 'Overdone' October Sell-Off
Top Consumer Staples Stocks
10 Most-Loved Stocks in Hedge Funds: Goldman's VIP List
Managing Currency Exposure in Your Portfolio
Exchange-Traded Fund – ETFs
An exchange-traded fund (ETF) is a basket of securities that tracks an underlying index. ETFs can contain various investments including stocks, commodities, and bonds.
Brexit Definition
Brexit refers to Britain's leaving the European Union, which was slated to happen at the end of October, but has been delayed again.
Risk Management in Finance
In the financial world, risk management is the process of identification, analysis and acceptance or mitigation of uncertainty in investment decisions. Risk management occurs anytime an investor or fund manager analyzes and attempts to quantify the potential for losses in an investment.
Fundamental analysis is a method of measuring a stock's intrinsic value. Analysts who follow this method seek out companies priced below their real worth.
Short Selling Definition
Short selling occurs when an investor borrows a security, sells it on the open market, and expects to buy it back later for less money.


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The Pine Island Glacier is about to calve another monster iceberg
This is doubly worrisome on the heels of the recent UN climate change report, which gave humanity an urgent deadline to cut carbon emissions: just 12 years.
Brandon A. Weber
It's the same glacier that calved in September 2017, losing an iceberg 4.5 times the size of Manhattan.
The size of this one, however, is about 15% bigger than the last. It's the sixth large-calving event from this glacier since 2001.
The irreversible collapse of the West Antarctic ice sheet would raise sea levels 20 feet, says the UN.
The Pine Island Glacier (a.k.a. PIG)
Photo by Mario Tama/Getty Images.
The area of the iceberg poised to calve off the Pine Island Glacier is about 115 square miles, or 300 square kilometers.
About one year ago, in Antarctica, the Pine Island Glacier calved an iceberg about 100 sq. miles in size—4.5x the size of Manhattan.
It's about to do it again—and this one is 15% bigger than the last, at 115 square miles.
"As the planet warms from 1.5°C to 2°C, the risks grow rapidly for some very dangerous tipping points, including the irreversible collapse of the West Antarctic ice sheet (which would raise sea levels 20 feet)," reads the UN's recent IPCC Report.
It's doubly (trebly?!) worrisome on the heels of the above UN IPCC report, which basically tells us we're screwed unless we take drastic action—and, I mean drastic—in order to curb emissions and slow the inexorable drift into an Earth that looks like one of those terrifying science fiction novels.
A 19-mile-long (30 kilometers) rift is splintering across the ice sheet
Pine Island Glacier: the movie. From Oct 2014 to recent calving in 108 #sentinel1 images @CopernicusEU @ESA_EO pic.twitter.com/oYKvelCKPd
— Stef Lhermitte (@StefLhermitte) October 13, 2017
That's the 2017 calving, in a GIF created by Stef Lhermitte.
If the West Antarctic ice sheet collapses, it will mean a 20-foot rise in sea levels. And it will release twice as much carbon into the atmosphere as exists today.
The fact that the United States has gone the opposite direction, abandoning the Paris Accord and even calculating a rise of 7 degrees (F) as acceptable and even inevitable when working on new automobile emission standards is contributing to a looming climate change catastrophe by 2040.
Vote like your lives depend on it, folks.
Because they do.
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Huge Iceberg Poised to Break Off Antarctica's Pine Island Glacier ›
A Giant Iceberg in West Antarctica Is Disintegrating, And Scientists ... ›
Pine Island Glacier ›
global warming glacier calving antarctica nature climate change environment


The truancy rate at Oakwood Junior High School rose to 14 percent during the 2017-18 school year, according to a Chambana Sun analysis of the latest Illinois schools report card.
The schools average daily attendance rate was 94 percent.
Students are considered chronically truant if they miss 5 percent of school days or more per year without acceptable excuses. The Oakwood CUSD 76 saw a chronic truancy rate of 5 percent during the 2017-18 school year, while the statewide rate was 11 percent.
The school enrolled 153 students in the 2017-18 school year, and average daily attendance was at 94 percent for the year, the Illinois State Board of Education reported. The average daily rate of attendance across the state was 94 percent.
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text:
" Articles in Category: Leslie Rutledge	"
GOP Furious That Arkansas' Republican AG Candidate Removed From Voting Rolls After Confirmation of Multi-State Registration, Voting
WARNING: Amount of irony in this story may lead to head explosion...
By Brad Friedman on 10/1/2014 5:03pm PT
[This article now cross-published by Salon...]
UC Irvine law professor Rick Hasen says this development, which he describes as coming from the "Irony Dept", is just "too delicious".
Leslie Rutledge, the Republican candidate for Attorney General in Arkansas, has been discovered to have been registered to vote in multiple states in addition to Arkansas, and even voted by absentee ballot in Arkansas' general election in November of 2008 --- after she had registered to vote in Washington D.C. [PDF] in July of the same year.
According to the Arkansas Democrat-Gazette, Rutledge has now been removed from Arkansas' voting rolls by the Pulaski County Clerk, after he confirmed that she was registered to vote in D.C., and possibly Virginia. The removal from the rolls may also lead to her ineligibility to be elected to office.
Rutledge's Arkansas absentee ballot request form for the 2008 general election is here [PDF]. And, indeed, her subsequent voter registration form from Virginia is here [PDF].
"For the AG candidate of the party who likes to scream about voter fraud to be registered in two (or three) places at once is ironic and amusing on its own," writes Matt Campbell of Arkansas' "Blue Hog Report", which was on this story from the jump.
"However, the bigger implication is Article 19, section 3, of the Arkansas Constitution," he adds, which states: "No persons shall be elected to, or appointed to fill a vacancy in, any office who does not possess the qualifications of an elector." If Rutledge is not registered in Arkansas, she no longer "possess[es] the qualifications of an elector."
But, believe it or not, none of that is the actual ironic part that Hasen was referring to in his piece on this today. Yes, it gets even more ironic!...
--- Click here for REST OF STORY!... ---
( 7 so far... )
Article Categories: Election Irregularities, Arkansas, Karl Rove, Election Fraud, Election 2008, Rights And Freedoms, Accountability, Voter Registration, Vote Caging, Republicans, Bush Legacy, Election 2014, NVRA, Leslie Rutledge


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FDA Says Nicotine-Free E-Liquids Are Tobacco Products in 'Certain Circumstances'
Manufacturers will have to guess which circumstances those are, because the FDA won't say.
Jacob Sullum | 8.19.2016 9:16 AM
Smoke NV
This week, responding to one of the lawsuits challenging its e-cigarette regulations, the Food and Drug Administration (FDA) further muddied the question of whether those regulations apply to products that do not contain tobacco-derived nicotine. The lawsuit, which was brought by Nicopure, a manufacturer of e-liquids and vaping systems, argues that such a result would be unfair, illogical, and illegal. In response, the FDA says Nicopure has failed to show that any of its nicotine-free liquids are actually covered by the regulations and therefore has no standing to challenge that aspect of the rules. At the same time, the FDA concedes that "e-liquids marketed as 'nicotine-free' may properly be considered tobacco products—or components or parts thereof—under certain circumstances."
What circumstances are those? "Some e-liquids 'claiming to be nicotine-free actually contain[] high levels of nicotine," the FDA says, quoting its regulations. "Others are tobacco flavored, and are thus 'made or derived from tobacco' regardless of their nicotine content."
Does that mean e-liquids are not subject to the FDA's burdensome, prohibitively expensive regulations as long as they do not contain nicotine or any other tobacco derivative? No, because the FDA's definition of "tobacco product" does not require nicotine or any other tobacco derivative.
The Family Smoking Prevention and Tobacco Control Act, the statute that gave the FDA authority over tobacco products, defines them as products "made or derived from tobacco that [are] intended for human consumption, including any component, part, or accessory of a tobacco product." In deeming e-cigarettes to be tobacco products, the FDA defined "component or part" as "any software or assembly of materials intended or reasonably expected…to alter or affect the tobacco product's performance, composition, constituents, or characteristics" or "to be used with or for the human consumption of a tobacco product." Hence vaping equipment, whether a closed, disposable e-cigarette or an open system with a refillable tank and parts that can be switched out, is a "component or part" of a tobacco product, which means it is also a tobacco product.
Does that mean a nicotine-free e-liquid is a "component or part" of a tobacco product—i.e., the vaporizer? The FDA can't or won't give a straight answer to that question. "The only nicotine-free e-liquids that the rule brings under the FDA's regulatory authority are those that are made or derived from tobacco (such as tobacco-flavored varieties) or that otherwise meet the definition of a 'component' or 'part,'" it says. "Thus, nicotine-free e-liquids not made or derived from tobacco are subject to the deeming rule only where they meet the definition of a 'component or part.'…Whether nicotine-free e-liquids meet this definition 'will be evaluated on a case-by-case basis.'"
That means a company like Nicopure cannot know ahead of time which of its products are covered by the regulations. It can only find out by asking the FDA about each one, a process that will carry its own costs, even if they do not rise to the hundreds of thousands or millions of dollars that each "premarket tobacco product application" is expected to cost. The FDA's position is that Nicopure can't challenge the potential regulation of its nicotine-free e-liquids because it does not know whether they will actually be regulated. Never mind that it doesn't know because the FDA won't say.
Jacob Sullum is a senior editor at Reason.
E-cigarettes FDA Regulation Litigation Tobacco Public Health


The 2.8-Å crystal structure of the complex formed by estradiol and the human estrogen receptor-α ligand binding domain (hERαLBD) is described and compared with the recently reported structure of the progesterone complex of the human progesterone receptor ligand binding domain, as well as with similar structures of steroid/nuclear receptor LBDs solved elsewhere. The hormone-bound hERαLBD forms a distinctly different and probably more physiologically important dimer interface than its progesterone counterpart. A comparison of the specificity determinants of hormone binding reveals a common structural theme of mutually supported van der Waals and hydrogen-bonded interactions involving highly conserved residues. The previously suggested mechanism by which the estrogen receptor distinguishes estradiol's unique 3-hydroxy group from the 3-keto function of most other steroids is now described in atomic detail. Mapping of mutagenesis results points to a coactivator-binding surface that includes the region around the "signature sequence" as well as helix 12, where the ligand-dependent conformation of the activation function 2 core is similar in all previously solved steroid/nuclear receptor LBDs. A peculiar crystal packing event displaces helix 12 in the hERαLBD reported here, suggesting a higher degree of dynamic variability than expected for this critical substructure.
Steroid and nuclear hormones exert their influence on target cells by binding to cognate members of the steroid/nuclear receptor superfamily of transcription factors (Fig. 1A). Members of this family are modular in structure with domains A-F, including discrete DNA binding domains and ligand binding domains (LBDs) (3, 4). The receptors are targeted to their respective promoters through specific interaction with cognate hormone response elements (3, 4), and regulate transcription in a ligand-dependent manner with the aid of various coactivators and corepressors (5–8). Additional levels of regulation are achieved through interactions with other systems such as molecular chaperones (4), cAMP-regulated kinases (9, 10), and AP1 activators (4, 11, 12). Members of this superfamily also regulate each other's expression through complex crosstalk pathways (13, 14). Together these form a rich and elaborate network by which lipophilic ligands regulate gene expression.
(A) Sequence alignment of LBDs from selected steroid and nuclear receptors. Secondary structure determined by crystallography is in green (α helix) and cyan (β sheet). Residues are highlighted by function: magenta (hormone binding), yellow (dimerization), or brown (hormone contacts C-terminal to Cys530 in the hERαLBD) (1). Helix 12 is shown as described by Brzozowski et al. (1). A red triangle shows the C terminus of the hERαLBD used for crystallization, and a navy blue triangle indicates the position of the intermolecular disulfide bond. The activation function 2 core and "signature sequence" (2) are underlined in red and navy blue, respectively. Vertical pink lines denote every 10 residues. (B) Stereo plot of the Cα backbone of a hERαLBD subunit with bound estradiol (carbons black, oxygens red) presented here. Helix 12 from a neighboring molecule is in blue. Drawn with dplot (G. Van Duyne, personal communication).
The transcriptional response to hormones or antihormones is rooted in conformational changes induced by specifically bound ligands. These changes have been implicated by biochemical and genetic analysis to be involved in transactivation, dimerization, phosphorylation, chaperone interaction, and corepressor inhibition (4). To better understand the molecular mechanism of these responses in chemical terms, crystallographic analysis has been carried out elsewhere on the liganded LBDs of two nuclear receptors, the all-trans retinoic acid receptor (RAR) (15) and the thyroid hormone receptor (TR) (16), and on the unliganded 9-cis retinoic acid receptor (RXR) (17). To extend the structure-function analysis to the steroid subfamily we present here a comparison of the 2.8-Å crystal structure of the estradiol complex of the human estrogen receptor α LBD (hERαLBD) and the progesterone complex of the human progesterone receptor LBD (hPRLBD) (18). A parallel study of the estradiol and raloxifene complexes of hERαLBD recently was published (1), the descriptions of which also are used in the comparison.
A fragment of the human ERα (residues 297–554) that contains the entire ligand binding ("E") domain with an N-terminal three residue (MDP) extension was overexpressed with pET23d in BL21(DE3)pLys S and purified in 5 M urea by estradiol-affinity chromatography (19) with 10 mM ammonium chloride added to prevent carbamylation of lysine residues. The purified product [a complex of hERαLBD with estradiol in 25 mM Tris (pH 7.4), 100 mM NaCl, 1 mM EDTA, 1 mM DTT, 5 M urea, 10 mM NH4Cl, 20 μM estradiol] was exchanged into 25 mM Tris (pH 7.4), 200 mM NaCl, 1 mM EDTA, 1 mM DTT, 20 μM estradiol, 0.1% β-octyl glucoside via multiple dialysis steps and concentrated by ultrafiltration to 18 mg/ml. Crystals were obtained by vapor diffusion at 18°C using hanging drops containing an 8-μl 1:1 mixture of the above protein stock solution and a well solution composed of 100 mM Tris (pH 7.6), 480 mM MgCl2, 10 mM Mg acetate, 10% ethylene glycol, 5% polyethylene glycol (PEG) 4000. Triangular prisms (space group R32; a = b = 147 Å, c = 338 Å in the hexagonal setting; two dimers per asymmetric unit) grew to full size (150 × 150 × 300 microns) in 14 days and diffracted to 3.2 Å. When this same crystal form was stabilized in 0.1 to 10 mM potassium aurocyanide, a new unit cell formed that had the same space group and a and b axes, but had a halved c axis of 169 Å. Crystals were stabilized in 100 mM Tris (pH 7.6), 510 mM MgCl2, 10 mM Mg acetate, 10% ethylene glycol, 5.5% PEG 4000, 10 mM KAu(CN)2 for 18 hr at 18°C; cryoprotected by a 15-sec equilibration in 100 mM Tris (pH 7.6), 510 mM MgCl2, 10 mM Mg acetate, 25.5% ethylene glycol, and 5.5% PEG 4000, and flash-frozen in liquid propane at liquid nitrogen temperatures. X-ray data were collected at 90–110 K in a nitrogen gas stream. Anomalous diffraction data were collected at NSLS beamline X4a on image plates at the gold LIII edge. Initial phases were obtained by single wavelength anomalous scattering (SAS) based on gold sites determined from an anomalous difference Patterson synthesis. Using the gold adduct as the parent, phases were improved by multiple isomorphous replacement (MIR) with derivatives produced in the presence of 0.1–1 mM KAu(CN)2 for 12 hr followed by 6 hr in a stabilizer with KAu(CN)2 and a second heavy metal (0.1 mM Au for ethyl mercury chloride, 1 mM Au for mersalyl and trimethyl lead acetate). Data from CHESS-A1 were collected on a 1 K × 1 K charge-coupled device at 0.91 Å. Home-source data were collected by using a Macscience DIP2000 image plate detector and mirror-conditioned Cu Kα. All data were processed by denzo (20) and merged with scalepack (20). Mercury and lead sites were found by difference Fourier synthesis, and heavy atom parameters were refined with ml-phare (21). Combined SAS and MIR phases were further improved by solvent flattening (22) using dphase (G. Van Duyne, personal communication) and by averaging density related by the noncrystallographic dyad with rave (23). The model was built with o (24) and refined by cns (25) by using a maximum likelihood target, bulk solvent correction, simulated annealing, noncrystallographic symmetry constraint and restraint, and restrained individual B factors. The structure was refined to an R factor of 22.3% and free R factor of 27.4%. See Table 1 for details on data collection and refinement.
There are two ERαLBDs in the crystallographic asymmetric unit related by a nearly exact noncrystallographic dyad. This arrangement, which resembles that of unliganded RXR, likely represents the physiologically relevant homodimeric form of ERα in estrogen-dependent transcriptional activation (26), and corresponds to the stoichiometry and rotational symmetry of the ER's DNA target (27). The fold of the individual ERαLBD is roughly similar to that seen in the structures of other liganded LBDs in the steroid/nuclear superfamily (1.2-Å rms deviation for ER vs. PR for helices 1–11). However, helix 12, which is not essential for the ligand binding or dimerization properties of the ERαLBD (28), extends away from the body of the domain and binds to the surface of a neighboring molecule (Figs. 1B and 2A). This intermolecular contact is somewhat similar to the intramolecular binding mode of helix 12 in the raloxifene-bound hERαLBD (1), where the antiestrogen displaces helix 12 from its position in the estradiol-bound complex. This artifactual interaction is caused by the perturbing effect of a fortuitous disulfide bond formed between the loops just preceding helix 12 in neighboring molecules as shown in Fig. 2A. The aberrant position of helix 12 seen in our hERαLBD structure underscores the high degree of positional variability exhibited by this important and inherently stable substructure.
Arrangement of hERαLBDs in the crystal structure. (A) The tetramer formed by the intermolecular disulfide bonds between Cys-530 of neighboring hERαLBD molecules and dimerization around the local dyad. (Inset) A schematization of the arrangement. Positions of the disulfides are marked with a yellow disc with red "S." Red symbols in the center of the tetramer and schematic show the crystallographic dyad, and the red arrow in the inset indicates the noncrystallographic symmetry dyad. (B) Comparison of the dimers of holo-hERαLBD, apo-hRXRαLBD, and holo-hPRLBD viewed down the local dyad (17, 18). The dimer interfaces of holo-hERαLBD and apo-hRXRαLBD are similar, with helices 7–10 as the major contributors. The holo-hPRLBD dimer interface is substantially different, composed predominantly of helices 11 and 12, as well as the extreme C-terminal tail. Drawn with ribbons (29).
Fig. 2B shows the mode of hERαLBD dimerization and its similarity to that seen in the crystal structure of the unliganded hRXRαLBD. The dimer interface observed here has been shown by mutagenesis to be essential for ER dimer formation (28, 30). In the hERαLBD, each protomer contributes 1,477 Å2, or roughly 13.3% of its solvent-accessible surface area to the interface, which is comparable to the 1,333 Å2, or roughly 11.2% of solvent-accessible surface contributed to the dimer interface of apo-hRXRα (17). Both of these interfaces are larger than that seen in the hPRLBD, which buries 705 Å2 of surface for each protomer (18). The much smaller dimer interface of the hPRLBD (18) is distinctly different (Fig. 2B), as the β-structure formed by the C-terminal strand of the hPRLBD intrudes on the homodimer interface seen in the LBD crystal structures of hERα and hRXRα. Gel filtration experiments on a slightly longer fragment of hERαLBD (297–566) confirm that the estradiol-bound hERαLBD is a dimer in solution, whereas the progesterone-bound hPRLBD used for the crystal structure elutes as a monomer (data not shown).
The hERαLBD dimer interface contains residues from helices 7, 8, and 9 as well as the loop between helices 8 and 9, but is dominated by a conserved hydrophobic region at the N terminus of helix 10/11 that forms a right-handed convex interhelical contact similar to that in resolvase (31), but with a smaller crossing angle (∼40° for resolvase versus ∼29° for ER). This is distinctly different than the left-handed coiled-coil predicted on the basis of the leucine-containing heptad repeat sequences in the ER and TR LBDs (28). Nuclear receptors such as RAR, TR, and 1,25 dihydroxy vitamin D3 receptor are likely to form heterodimers with ER/RXR-like dimer interfaces because the residues that correspond to those in the dimer interfaces seen in the hERα and hRXRα crystal structures are highly conserved in these receptors and have been implicated in dimerization by mutagenesis (17, 32–35).
In the hERα and hPR ligand-binding pockets, the hormone is oriented by two types of contacts: hydrogen bonding at the two ends and hydrophobic van der Waals contacts along the body of the hormone. Estradiol and its analogues are unique in having a 3-hydroxyl group as opposed to the 3-keto group found in other steroids. The uniqueness of this estrogenic functionality is reflected in the hydrogen-bonding pattern of the hERα and hPR ligand-binding pockets shown in Fig. 3A and ref. 1. At the end of the binding pocket that holds the A-ring of the steroid, the estrogen receptor is unique in having a glutamate (Glu-353) to accept the hydrogen bond donated by the estrogenic 3-hydroxyl group. The other steroid receptors, which bind 3-keto steroids, have a conserved glutamine at the corresponding sequence position where the hPRLBD structure shows the amido NH2 group of the Gln-725 donating a hydrogen bond to the 3-keto group of progesterone (18). Fig. 3A also shows how the conserved arginine (Arg-394 in hERα, Arg-766 in hPR) serves to correctly orient and position the discriminating glutamate or glutamine side chain via highly polarized, water-mediated hydrogen bonds. Through a nearly identical structural arrangement in the hERαLBD and hPRLBD, the side chain of this arginine is itself braced by a hydrogen bond to the carbonyl of the residue preceding a conserved phenylalanine (Phe-404 in hERα, Phe-778 in hPR), which is fixed by its van der Waals contact to the A-ring of the steroid (Fig. 3 B and C). Thus, the recognition of the 3-oxy function of the hormone is coordinated with a van der Waals contact to its hydrophobic rings. At the other end of the ligand, however, the mechanism of discrimination is less clear. In the hERαLBD, the 17-hydroxyl is hydrogen-bonded to the δ nitrogen of His-524 (Fig. 4; ref. 1), whereas the hPRLBD (18) possesses a less definite discriminating functionality for progesterone's 17-methyl-keto moiety (Fig. 3A). The hormone is positioned in the same orientation in the hERαLBD as in the hPRLBD (18), but both are in the opposite direction to that predicted on the basis of the nuclear receptor structures (2).
Specificity determinants of the hormone-binding site specifies 3-hydroxy vs. 3-keto steroids. (A) The hydrogen-bonding network as seen in the hERαLBD and hPRLBD (18). The discriminating relationship of Glu/Gln to the 3-hydroxy/keto of the steroid is supported by a network of water-mediated hydrogen bonds involving the side chain of a conserved Arg and backbone carbonyl of a conserved Phe that, in turn, are fixed by hydrophobic contacts with the steroid ring. Note that the PR has no obvious hydrogen bonding discrimination at the 20-keto position of progesterone comparable to the hydrogen-bonding interaction seen between the 17-hydroxyl of estradiol and His-524. (B) Space-filling representation of estradiol in the ligand-binding pocket of hERαLBD and progesterone in the ligand-binding pocket of hPRLBD (18). For the proteins, carbon atoms are gray, oxygen atoms red, sulfur atoms yellow and nitrogen atoms blue. For the hormones, carbon atoms are cyan, oxygen atoms magenta. Drawn with midas (36). (C) Schematic of estradiol in the hERαLBD ligand-binding pocket in the structure shown here; hormone (red) rings are lettered, and carbon atoms are numbered. Residues hydrogen bonded directly to the hormone are blue. Dashed lines indicate hydrophobic van der Waals contacts with the hormone. Residues conserved among the steroid receptors are green, and variable residues are black. Residues contributed by helix 12 (1) are not shown.
A stereo view of the 2Fo-Fc Sigma A weighted (37) electron-density map contoured at 1.2σ showing estradiol in the hERαLBD hormone-binding pocket. Drawn with setor (38).
The hydrophobic residues implicated in direct hormone binding in the ER and PR structures are highly conserved (Figs. 1A and 3C), indicating a commonality of pocket architecture. Eighteen residues in ER contact bound estradiol; of those 18 sequence positions 14 are occupied by PR residues that contact bound progesterone and 10 of those have similar side chains in all of the steroid receptors (Fig. 3C). The variations in the van der Waals surface of the binding pocket, however, appear designed to complement the distinctive contours of the cognate hormone. A flat aromatic A-ring, and the absence of a 19-methyl group protruding from its surface distinguish the van der Waals surface of the estradiol molecule. Fig. 3B shows that the bulky side chain of Leu-387 in the ER's binding pocket is replaced by the slender, more flexible methionine side chain in PR to accommodate progesterone's 19-methyl group. These variations on a common theme indicate that it is highly unlikely that the natural ligands of the steroid receptor subfamily bind in a mode that is substantially different than that seen in the ER and PR.
The cooperative stereochemistry of ligand binding provided by the network of specific hydrogen bonds and van der Waals contacts underscores the importance of ligand-induced stability in the steroid/nuclear receptor superfamily. Note that the absence of hormone from the hERα and hPR LBDs would leave cavities of 450 Å3 (1) and 603 Å3 (18), respectively and thus would require significant readjustments to retain stability of the hydrophobic interior of the domain. In the two hormone-bound LBDs discussed here, it is clear that this cooperative network of hormone contacts not only accounts for the specificity of ligand binding, but allows the hormone to function as the structural core for the bottom half of the LBD, and therefore the scaffold around which this region folds.
Coactivators are necessary for the hormone-bound ER and PR to stimulate transcription (39). The ligand-dependent interaction between steroid/nuclear receptors and coactivators depends on the activation function 2 (AF-2) core located in helix 12 (40). Crystal structures comparing the unliganded LBD from RXR and its liganded counterpart from RAR indicate that the bound hormone induces a dramatic repositioning of helix 12 (15, 17). Except for the artefactual alignment of helix 12 in the ER complex reported here, the structures of all hormone-bound LBDs solved to date (RAR, TR, ER, and PR) shows helix 12, and hence the AF-2 core in the same position (1, 15–18). Importantly, the crystal structure of the antiestrogen, raloxifene, bound to the hERαLBD (1), as well as modeling of the antiprogestin, RU486, bound to the hPRLBD (18), shows a displacement of helix 12 from this common "active" position, thereby reinforcing the generally accepted view that the active state produced by the hormone is caused by the contribution of the conserved helix 12 to a coactivator-binding surface. Helix 12 is fixed in this active position both by contacts with the hormone and residues on the surface of the domain (Fig. 5). The stabilizing effect originally attributed to an ionic interaction in RARγ between the conserved glutamate of the AF-2 core and a lysine in helix 4 does not seem to be general (15). In TRα, ERα, and PR, stability appears to arise from hydrophobic van der Waals contact between the invariant hydrophobic side chain that follows the conserved glutamate of helix 12 and the hydrophobic components of the side chains from helix 4 (1, 16, 18). In addition to helix 12, residues in ERα such as Lys-362 (41) and Val-364 (42) in the highly conserved loop between helices 3 and 4 [the so-called "signature sequence" (2) indicated in Fig. 1A] have been implicated by mutagenesis as contributing to a substructure responsible for coactivator interaction. These results suggest a coactivator-binding interface that appears to encompass the exposed surfaces of helices 3, 4, and 12, and the "signature sequence" loop, as seen in Fig. 5.
Inferred coactivator-binding surface. View of hormone-bound hERαLBD and residues important for transactivation as determined by mutagenesis. The active (red) and inactive (magenta) positions of helix 12, red and magenta, are based on the published figures of the hormone- and antihormone-bound hERαLBD structures (1). The domain is oriented as in Fig. 1B. Drawn with ribbons (29).
Hormone-dependent activation is predicated on the movements of helix 12 from one position to another. It is noteworthy in this regard that helix 12 as seen in the unliganded RXR, the raloxifene complex of ER (1), and the aberrant interaction reported here, as well as in its hormone-stabilized active state, retains its structure irrespective of its position. Unlike most helices in globular proteins, the integrity of helix 12 is independent of specific stabilizing tertiary interactions. The positional variability of this robust substructure appears to be a critical attribute of the steroid/nuclear receptors in their variable response to both natural and synthetic ligands.
We thank Dr. Daniel Gewirth for important contributions early in the project, Dr. Geoff Greene (University of Chicago) for supplying the plasmid from which the final construct was derived and the estrogen affinity column, Drs. Craig Ogata (NSLS X4a) and Steve Ealick (CHESS-A1) for synchrotron access, Dr. Roderick Hubbard (University of York, United Kingdom) for providing a stereo diagram of helix 12, and Drs. Dino Moras (Institut de Génétique et de Biologie Moléculaire et Cellulaire, Ilkirch, France) and Robert Fletterick (University of California, San Francisco) for coordinates of the liganded hRARγ and rTRα LBDs, respectively. D.M.T. was a National Institutes of Health predoctoral trainee (GM07227), and Y.W. was supported by a National Institutes of Health Postdoctoral Fellowship. This work was supported in part by National Institutes of Health Grant GM15225.
↵* D.M.T. and Y.W. contributed equally to this work.
Data deposition: The atomic coordinates and structure factors reported in this paper have been deposited in the Protein Data Bank, Biology Department, Brookhaven National Laboratory, Upton, NY 11973 (reference nos. 1A52 and R1A52SF).
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As we get older and wiser, it seems like there is less and less time in every day. We'd like to think it's because we have become more mature and responsible, and have more important obligations getting packed into our schedules. But, we're pretty sure it has more to do with watching too many cute animal videos on our phones and also not paying attention to what time it is. Oops!
Don't fall into those same habits like we have! You definitely don't want to be late for any obligation when you're in your costume, especially if you're all dressed up as the White Rabbit from the classic story Alice in Wonderland. The housing is sturdy plastic and the face is a sticker decal. It's fastened on a plastic chain and can be easily worn around your neck.
We should warn you that you can't actually tell time with this clock, but having this hefty faux-pocketwatch around your neck will keep reminding you to really check the time using your watch or your phone. Just don't get distracted by adorable kitten videos; it's an easy trap to fall into. It gets us every time!
Perfect for my white rabbit -Alice in Wonderland costume!!
Bought it with the white rabbit costume so it went hand in hand. Everyone loved it!
Same quality as pictured. Large plastic clock with clock face sticker attached and it comes with the chain. Good price for what you get.
This works wonderfully for our Alice in Wonderland play! Large enough to be seen by audience. Good price!
A little bigger than expected but it will work fine.


text:
Get the best out of this historic and varied North American city
By Angelina Villa-Clarke
Founded by the French in 1608, Canada's Québec City is one of the oldest cities in North America – and arguably one of the most picturesque. Its clifftop position gives dramatic views across the St Lawrence River, while Old Québec, a World Heritage Site, seduces with its cobbled streets and towering church spires. Fiercely French at heart, make the most of your afternoon arrival and extended port time there with this essential guide.
Oleksiy Maksymenko/Robert Harding
1pm-4pm: Explore the historic quarter
Kick off your visit to Québec City with a Princess excursion that takes you around the historic quarter. The old heart of the city is full of atmosphere with ancient buildings and pretty bistros. The tour will take you to both the Lower and Upper Towns. Start in the restored Place Royale, home to Notre-Dame-des-Victoires Church, one of the oldest stone churches standing in North America. Soak up the quaint ambience of the surrounding streets, including Petit-Champlain, then jump aboard the funicular to the walled Upper Town. Street musicians give this part of the city a Parisian feel, especially around Place d'Armes. Here you can stroll around the boutiques and refuel in one of the cosy cafés. The tour also includes a visit to the Place de l'Hôtel de Ville and Ursuline Monastery, as well as the Seminary of Québec.
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4pm-8pm: Have a local experience
From Old Québec, meander back to the ship to be whisked away for a 'sugar shack' dining excursion. Be warned: arrive hungry, as you'll be served an endless line-up of Québécois dishes. From maple ham to maple candies, you can work off the sugar rush with a guided tour around the maple museum, while live folklore music will transport you to bygone days, before you're taken back to the pier.
9am-10:30am: See the natural side
It's a new day. After leaving the ship, walk off breakfast with a leisurely stroll to the tranquil Plains of Abraham. Now a stately park, stretching over 267 acres, it's the site of a pivotal battle where British troops defeated the French in 1759 – the outcome of which changed the course of North American history. Thankfully the scene is more peaceful these days. Check out the Joan of Arc Garden, which has a display of over 150 varieties of plants and flowers.
10:30am-12pm: Take in a museum
Time for a culture fix with a visit to the Musée de la Civilisation. Retrace your steps to the old port and on the way you'll find this world-class museum, which explores the history of Québec and the province's aboriginal heritage and artworks. With interactive elements and rotating shows, there's much to hold your interest. Our advice: choose only one or two exhibits so you're not overwhelmed with the array of items to take in.
Chez Rioux & Pettigrew
12pm-1:30pm: Feast at lunch
You'll be spoilt for choice when it comes to dining out in the city, but for something different, head to Chez Rioux & Pettigrew – a five-minute walk away from Musée de la Civilisation. Once an old general store dating back to 1860, it serves classic French cuisine. Take your seats in a dining room decorated with remnants from its past – think tea tins, barrels of molasses and sacks of flour – and try the blind menu for a seasonal journey through Québec. It's a sensory adventure.
Visit Canada and New England from Southampton
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1:30pm-2pm: Explore ancient architecture
Visit the 370-year-old Notre-Dame de Québec Cathedral-Basilica for a moment of reflection. Standing on the site of the chapel constructed by Samuel de Champlain, the founder of Québec City, its neo-baroque gilding and religious paintings are truly breathtaking.
2pm-3pm: Stop for a cuppa
For a touch of magic, the fairytale-like Fairmont Le Château Frontenac is the perfect place for a cup of tea and slice of cake. It may be a luxury hotel, but it's also one of the city's most iconic buildings, its turrets dominating the skyline since 1893. Said to be the most photographed hotel in the world, it has welcomed everyone from HM The Queen to Winston Churchill to Steven Spielberg. In celebration of its noted history, there is also a guided tour that reveals more about its layered past.
3pm-4pm: Soak up the views
Finally, it's on to Dufferin Terrace – a 671m-long wooden boardwalk that stretches from the foot of the Citadelle (Québec's famous military fort) to Fairmont Le Château Frontenac. The best spot to take in the views – the St Lawrence River and across to the Île d'Orléans – soaking up the vista is the best way to say farewell to the city before you return to the ship.
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Angelina Villa-Clarke
Angelina has been a travel journalist for the past 20 years, having caught the travel bug when she was a child. Before going freelance nine years ago, she was associate editor on British Airways' High Life Magazine and travelled widely. She now writes for a wide range of magazines and newspapers. Her next assignment is in NYC and later this year she's headed to Mekong Delta in Vietnam.
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In a UK government survey, the contents of 74% of lunch boxes for children were below the nutritional standards set for school meals.
Anyone who works in a school or nursery sees children who bring in a jam sandwich on white bread, a packet of crisps and a bar of chocolate for lunch. Packed with salt, fat, sugar, no veg, no protein, no fruit – a disaster.
There is no guideline for the amount of sugar, which is found in carbohydrate, starchy foods, as well as in fruit and vegetables. Added sugar, which causes tooth rot, is high in juice drinks, fizzy drinks and many processed foods.
It can be hard to think of something appetising that's also healthy, We hope these suggestions help you pack healthy lunch boxes for children.
These documents are supplied as PDF files.


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Moonshine Finds New Craftsmen and Enthusiasts
IN early April, Kris Comstock, a representative for the Buffalo Trace distillery in Kentucky, conducted a seminar on bourbon at Char No. 4, a bar in Cobble Hill, Brooklyn, that offers 150 kinds of American whiskey.
Among the bourbons he poured were Buffalo Trace, Eagle Rare and Blanton's. But his students weren't interested in those.
"The first thing that everyone wanted to taste was the white dog," he said. "We make products that win amazing awards all around the world, and they want to taste the white dog."
White dog, or white whiskey, is, basically, moonshine. It's newborn whiskey, crystal-clear grain distillate, as yet unkissed by the barrel, the vessel that lends whiskey some or all of its color and much of its flavor. And white dog is currently having its day.
"Aging in wood has many beautiful effects on a spirit," said Tad Carducci, half of the cocktail consulting duo known as the Tippling Brothers. "But it does tend to disguise whatever the base spirit is. When you strip that away, you're getting a real sense of what wheat offers, or rye or corn."
Unlike vodka, in which the source grain is often purposefully purified to a vanishing point, white dogs are pungently fragrant, with a chewy sweetness to them.
This spring, Buffalo Trace began a limited commercial release of its white dog, which until now was available only as a much-coveted souvenir from the distillery's gift shop. The bottles took their place on store shelves next to a growing line of colorless whiskeys.
Most are the work of young micro-distilleries like Death's Door, in Wisconsin; Finger Lakes Distilling, in upstate New York; Tuthilltown, in the Hudson Valley; the Copper Fox Distillery, in northern Virginia; and House Spirits, in Portland, Ore.
There are so many white dogs on the market now that Joe Carroll, owner of Fette Sau, a bar and restaurant in Williamsburg, Brooklyn, offers a white-whiskey flight. Passengers on that flight, he said, include everyone from informed whiskey aficionados to inquisitive novices who think whiskey is born brown. "They're curious because they don't know anything about it," he said.
According to Max Watman, the author of the recently published "Chasing the White Dog: An Amateur Outlaw's Adventures in Moonshine" (Simon & Schuster), the trend is being fueled by two very differently motivated groups: practical-minded distillers and ravenously questing enthusiasts. "It's obviously a boon to small distilleries," Mr. Watman said. "If you're making whiskey, you've got to keep the lights on and wait. It helps to be able to sell something right away. But that's not the end of the story. I think anybody who's ever toured a distillery and tasted this stuff coming right off the line is surprised at how delicious it is. Everybody says, 'Wow, you should sell this!' "
The "you should sell this" moment for Death's Door's founder, Brian Ellison, came in early 2008 when he was preparing to age some red-winter-wheat-based distillate. A small Chicago distributor thought the raw liquor was so good he asked for 50 cases as is, and quickly found buyers.
"I always thought at some point people would get tired of it," Mr. Ellison said. Instead, Death's Door has sold more white whiskey in the first quarter of this year than it did in all of last year. Mr. Ellison is thinking of putting in some spring wheat to keep up with demand.
"The word 'curiosity' is very apropos," Mr. Carducci said. "People who are spirit geeks are always looking for the next curiosity. But what happens is they become hooked and think it's an actually respectable spirit."
Gable Erenzo, a distiller at Tuthilltown, said that its Hudson New York Corn Whiskey — one of the earliest of the new white dogs to hit the market — has been steadily creeping up in sales, and he is not surprised. "We knew this was going to happen," he said. "People, especially bartenders, were excited when they heard we were making a corn whiskey."
Not just bartenders, either. Even though home distilling has long been illegal in America, interest in it is rising. The Web site homedistiller.org has 5,500 members, with handles like Kentucky Shiner, upinthehills and toofless.
One New York state moonshine hobbyist with more than 30 years' experience behind various stills, who asked that his name not be used because of the legal issues, said the commercial distillers are "trying to replicate traditional methods, which is essentially what I do."
He said he was not surprised by the advent of commercial white dogs. "I've been telling people for years that they have to taste corn whiskey, so that when they taste whiskey, they can find their way around the inside of their mouth."
That said, he's not overly impressed with what's coming out. "The hobby distillers who are on the foodie bent are making better whiskey than you can buy. Period. No question about it. You just can't do as good a job making 1,000 gallons at a time as you can making 10 gallons a time. There's people making white dog that is mind-blowing."
All this attention is focused on a kind of spirit that's been around as long as there have been hills to hide stills. While moonshines of yore found a test of their mettle in whether they could keep the Xs on Pappy Yokum's eyes, today's legal lightnings are seen as finessed expressions of the spirit maker's art.
"You've got less to hide behind," Mr. Watman said. "You can mask a lot in a heavily charred barrel. You don't get any pass with white whiskey. All you have is an expression of the distiller's craft and the agriculture from which it came. It ups the stakes of the craft end of it."
With that clarity in mind, the mixologists playing with this new toy are keeping things simple, building on standard cocktails that highlight the grain spirits' natural flavors.
Mr. Carducci used Death's Door as the base of his Albino Old-Fashioned at Bar Celona in Williamsburg, Brooklyn, where he did some consulting work.
Damon Boelte, bar manager at Prime Meats in Carroll Gardens, Brooklyn, uses the same brand for the Good Word, his white-dog take on the classic Last Word.
Ehren Ashkenazi, beverage director at the Modern, uses it for Devil in White, a spin on the Manhattan, and Jim Meehan, of PDT, pairs Finger Lake Distilling's Glen Thunder corn whiskey with sake and Galliano L'Autentico in his Brewer's Breakfast.
Mr. Carroll, of Fette Sau, wonders whether the current fascination with this baby spirit will last.
"It will be interesting to see if the distilleries continue selling white dog when all their other whiskeys mature," he said.
For Mr. Watman, however, as long as there are whiskey drinkers in the world, there will be a place for white dog. "Part of it is an enthusiasm for a spirit we already love," he said. "If you love whiskey, you're going to love raw whiskey, too. It's another way to taste the same thing."
By ROBERT SIMONSON
NRA Launches YouTube Mixology Contest
[PRESS RELEASE] (Chicago) Shake it up... or stir it! Step out from behind the bar and into the national spotlight by entering the Star of the Bar competition on YouTubeTM - a nationwide search for the country's most creative mixologist at the National Restaurant Association's 2010 International Wine, Spirits & Beer Event (IWSB). Professional mixologists and amateur "bar chefs" are encouraged to submit a ninety-second video of themselves preparing their original signature cocktail - utilizing at least one Bacardi product - along with its written recipe by April 26, 2010.
The individual who creates the most original drink in the most entertaining way will not only have the opportunity to create incredible industry connections and gain bragging rights, but also take home a $5,000 cash prize, have their cocktail featured on the menu at Rockit Bar & Grill through May 2010, and have their recipe included in American Airlines American Way magazine. The Star of the Bar competition is sponsored by Bacardi.
"Culinary cocktails and signature drinks are hot trends on restaurant menus this year, highlighting that more mixologists are taking a chef's approach to beverages," said David Gilbert, chief operating officer of the National Restaurant Association. "We are excited to see the submissions for the 2010 Star of the Bar competition and look forward to learn how the contestants showcase their original drink recipes."
YouTube users will cast their votes to select six semi-finalists for the Star of the Bar title through April 26, 2010. Those six individuals will be flown to Chicago on American Airlines to mix, stir and shake their signature cocktail live at IWSB on Sunday, May 23. Event attendees will vote to select three finalists who will compete for the title.
The three finalists will then compete live that evening at the first-ever IWSB After Party at Rockit Bar & Grill, where an expert panel will select the ultimate Star of the Bar competition winner.
Interested mixologists should submit a ninety-second (or less) video demonstrating their cocktail and an original written recipe at www.winespiritsbeer.org by Monday, April 26, 2010. The cocktail recipe must include at least one Bacardi product.
No purchase is necessary. Limit one video submission per person. Contest open only to legal residents of the 50 United States and the District of Columbia, 21 years of age or older. Void where prohibited or restricted by law. See Official Contest Rules at the IWSB Web site.
Wide-ranging solutions for more successful and profitable bar programs will be available to restaurant operators during the National Restaurant Association's 2010 International Wine, Spirits & Beer Event at Chicago's McCormick Place, held May 23-24, 2010. In addition to exhibits by established and emerging wine, spirits and beer producers from around the world and exclusive food-alcohol pairing stations, IWSB attendees may attend expert-led education sessions that guide restaurateurs and bar managers to success. IWSB, held in conjunction with the Association's 2010 Restaurant, Hotel-Motel Show, is the restaurant and hospitality industry's only forum focused exclusively on restaurant and hospitality operator beverage alcohol-related needs.
Now in its third year, IWSB will be held in a separate exhibit area of McCormick Place during NRA Show 2010, and gather brewers, vintners and distillers, leading beverage experts, beverage alcohol buyers and more in one exclusive area.
The IWSB education sessions and exhibits will take place in Grand Ballroom (McCormick Place South, Level 1).
The annual National Restaurant Association Restaurant, Hotel-Motel Show is the largest single gathering of restaurant, foodservice and lodging professionals. The NRA Show 2010 will be held May 22-25 at McCormick Place in Chicago. The event attracts tens of thousands of attendees and visitors from all 50 states and 100+ countries, and showcases more products, services, innovative ideas and other growth opportunities than any other industry event. For more information, visit the Show Web site at www.restaurant.org/show.
Founded in 1919, the National Restaurant Association is the leading business association for the restaurant industry, which comprises 945,000 restaurant and foodservice outlets and a workforce of nearly 13 million employees. Together with the National Restaurant Association Educational Foundation, the Association works to lead America's restaurant industry into a new era of prosperity, prominence, and participation, enhancing the quality of life for all we serve. For more information, visit our Web site at www.restaurant.org.
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Breaking: Soni to step down as RPS president
Royal Pharmaceutical Society president Ash Soni is to step down from his role, having confirmed today (Tuesday July 9) that he will not seek re-election at the RPS Assembly on July 18. He will continue to be a member of the RPS Assembly and English Pharmacy Board.
Mr Soni commented on his decision not to contest the forthcoming election: "From my personal perspective it's the right time for me to focus on other areas where I will have the time to support the further development of pharmacy and pharmacists."
He added that he planned to devote more time to his roles at the National Association of Primary Care and at NHS England, where he is local professional network (LPN) chair.
Mr Soni began his current term on July 18 2017, having held the role of RPS president on two previous occasions.
RPS chief executive Paul Bennett thanked Mr Soni for the "considerable contribution" he had made in his time as RPS president "over many years".
Mr Bennett said: "Having worked with Ash during his recent presidency I know this will not be an easy decision for him to reach, but I respect his decision to not contest the forthcoming elections and in doing so give opportunity for other elected members sitting on the Assembly to take on this demanding role."
The RPS said Mr Soni had overseen the body's relocation from its old headquarters in Lambeth High Street to East Smithfield, which it claimed had brought "substantial savings in running costs, helping to secure the long-term future of the Society for its members".
Mr Soni was also a member of the rebalancing medicines legislation and pharmacy regulation programme board that helped secure a criminal defence around inadvertent dispensing errors in registered pharmacies.
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