text:
14-16 Allen St #3, Somerville, MA, 02143
Listing Agent: Charles Ball | Agent phone: 617-893-2100
Address: 14-16 Allen St #3
Somerville's fastest changing address is right here beside the newly opened Union Square T station and next door to the under-construction USQ, a 17 acre mixed use project of residential, retail, office, lab space, and a 27000 sf neighborhood park! Renovated 3 family house offers 3 modern 2br units, flexible layouts, ample parking, and 1c garage. Modern kitchens with quartz countertops; gorgeous hardwood floors, spacious rooms with over 1100 sf per unit. With the Greenline at the end of Allen Street, newer windows, bathrooms, and high efficiency systems, these rental units have ridiculous investment upside. WalkScore 94 and perfect BikeScore of 100; just minutes to Assembly Row, Harvard, MIT, and Downtown Boston.
Listing Agent: Charles Ball Agent phone: 617-893-2100 Courtesy of: Berkshire Hathaway HomeServices Commonwealth Real Estate Office phone: 617-666-2121 The property listing data and information, or the Images, set forth herein were provided to MLS Property Information Network, Inc. from third party sources, including sellers, lessors, landlords and public records, and were compiled by MLS Property Information Network, Inc. The property listing data and information, and the Images, are for the personal, non commercial use of consumers having a good faith interest in purchasing, leasing or renting listed properties of the type displayed to them and may not be used for any purpose other than to identify prospective properties which such consumers may have a good faith interest in purchasing, leasing or renting. MLS Property Information Network, Inc. and its subscribers disclaim any and all representations and warranties as to the accuracy of the property listing data and information, or as to the accuracy of any of the Images, set forth herein. Privacy Policy Notice: All information collected voluntarily from you will be used to personalize your experience, improve our website and improve our customer service. This information will not be shared with any other third persons or entities. Updated: 27th January, 2023 12:48 AM (UTC)


The insect short neuropeptide F (sNPF) family has been shown to modulate diverse physiological processes, such as feeding, appetitive olfactory behavior, locomotion, sleep homeostasis and hormone release. In this study, we identified the sNPF (BdsNPF) and its receptor (BdsNPFR) in an important agricultural pest, the oriental fruit fly Bactrocera dorsalis (Hendel). Afterwards, the receptor cDNA was functionally expressed in Chinese hamster ovary cell lines. Activation of BdsNPFR by sNPF peptides caused an increase in intracellular calcium ions, with a 50% effective concentration values at the nanomolar level. As indicated by qPCR, the BdsNPF and BdsNPFR transcripts were mainly detected in the central nervous system and antennae, and they showed significantly starvation-induced expression patterns. Furthermore, we found that the starved flies had an increased electroantennogram response compared to the normally fed flies. However, this enhanced olfactory sensitivity was reversed when we decreased the expression of BdsNPF by double-stranded RNA injection in adults. We concluded that sNPF plays an important role in modulating the olfactory sensitivity of B. dorsalis upon starvation. Our results will facilitate the understanding of the regulation of early olfactory processing in B. dorsalis.
Jiang, Hong-Bo, Shun-Hua Gui, Li Xu, Yu-Xia Pei, Guy Smagghe, and Jin-Jun Wang. 2017. "The Short Neuropeptide F Modulates Olfactory Sensitivity of Bactrocera Dorsalis Upon Starvation." Journal of Insect Physiology 99: 78–85.
Jiang, H.-B., Gui, S.-H., Xu, L., Pei, Y.-X., Smagghe, G., & Wang, J.-J. (2017). The short neuropeptide F modulates olfactory sensitivity of Bactrocera dorsalis upon starvation. JOURNAL OF INSECT PHYSIOLOGY, 99, 78–85.
Jiang H-B, Gui S-H, Xu L, Pei Y-X, Smagghe G, Wang J-J. The short neuropeptide F modulates olfactory sensitivity of Bactrocera dorsalis upon starvation. JOURNAL OF INSECT PHYSIOLOGY. 2017;99:78–85.
Jiang, Hong-Bo, Shun-Hua Gui, Li Xu, et al. "The Short Neuropeptide F Modulates Olfactory Sensitivity of Bactrocera Dorsalis Upon Starvation." JOURNAL OF INSECT PHYSIOLOGY 99 (2017): 78–85. Print.


Thank you for these beautiful and well-crafted thoughts and words.
I think it's an important message for all and in order for it to get more views, I've copied it into the "General Discussion" area of the Forum.
(If you're not happy with my doing so, please do let me know).


text:
threshersbaseball.com | The Official Site of the Clearwater Threshers
Individual Tickets Promotions Threshers Group Outings Weekly Promotions Threshers Suites & Club Level Threshers Season Tickets Spectrum Field Seating Map Lil Anglers Kids Club Silver Sharks Seniors Club
Schedule Game-by-game Results Clearwater Threshers 2020 Game Schedule
Roster Downloadable Roster Watch Video MiLB.TV Listen Live Game Notes
Tickets & Promotions Schedule Stats & Scores Team News Shop Contact Us
Spectrum Field A-Z and Directions
Spectrum Field A-Z
While in the ballpark, tickets for future games may be purchased at the Customer Service/Advance Tickets window located on the first base side of the main concourse behind Section 106. Also purchase tickets at ThreshersBaseball.com.
The Administrative Offices can be found on the West Side of the ballpark off of Old Coachman Road. The Offices are open Monday-Friday from 9am-5pm.
Animals are not allowed in the ballpark, with the exception of special events and service animals.
PA and video board announcements can be arranged for a nominal fee by visiting Guest Services behind Section 106 before the end of the second inning.
The ATM is located on the first base side of the main concourse.
Bags larger than 16x16x8 will not be permitted in the ballpark. The Threshers reserve the right to search any and all bags entering the ballpark.
Full-size baseball bats are prohibited from entry by guests to Spectrum Field.
BERM SEATING
Blankets are permitted to be brought in to the park for berm seating. Chairs, folding chairs, camp chairs, and the like, are not permitted to be brought in to the park.
All guests entering Spectrum Field must have a ticket, including children. Tickets for children ages 4 and under are free, but still must be issued by the BayCare Box Office for entry.
The Customer Service/Advance Tickets window is located on the first base side of the main concourse behind Section 106. Guests can report problems, check for lost and found items and claim prizes at this location. Tickets for future games may also be purchased here.
From Tampa: Highway 60 (Courtney Campbell Causeway) West. Cross over Highway 19 and go to the next stoplight (Old Coachman Road). Turn right (North) at Old Coachman Road. Go North through the Drew Street intersection. Stadium will be on right. 601 N. Old Coachman Road
From the North: U.S. Highway 19 South to N.E. Coachman Road (State Road 590). Turn right (West) onto N.E. Coachman Road and go to the first stoplight. Turn left (South) onto Old Coachman Road. Stadium will be on the left. 601 N. Old Coachman Road
From the South: U.S. Highway 19 North to Gulf to Bay Blvd. (Highway 60). Exit Highway 19 at the Gulf to Bay/Highway 60 exit. After exiting, turn left (West) onto Gulf to Bay/Highway 60 and go to the next stoplight (Old Coachman Road). Turn right (North) onto Old Coachman Road. Go North through the Drew Street intersection. Stadium will be on right. 601 N. Old Coachman Road
From the West/Clearwater Beach: Drew Street East approximately 3.5 miles to Old Coachman Road. Turn left (North) onto Old Coachman Road. Stadium will be on the right. 601 N. Old Coachman Road.
The First Aid office is located on the first base side of the main concourse. Guests can either report to this office or contact an usher if in need of medical assistance.
FOOD AND DRINK POLICY
No food, bottles, coolers, or cans may be brought into the ballpark.
Any foul ball hit into the stands may be kept. Guests are not permitted on the field or to reach into the playing area. Foul balls may be dangerous, so please be alert at all times and aware of the potential hazards.
GATES OPEN
Ballpark gates open one hour prior to the scheduled game time with the exception of Saturdays (Gates open at 5:00 p.m. for a 6:15 p.m. game) and Fridays (Gates open at 5:30 p.m. for a 6:15 p.m. game).
HANDICAPPED SEATING
Disabled seating is available all throughout the ballpark. Limited wheelchair seating is available through the ticket office in person or on the telephone. One companion seat is available for purchase with each wheelchair space. An elevator is available for disabled use on the first base side of the stadium (South Parking Lot). Drop-off is available on the West Side of the ballpark (no elevator access here). Please contact an usher for assistance entering and exiting the ballpark.
There's a special area of Spectrum Field reserved especially for our younger guests! The leftfield corner of the concourse houses a playground and special children's concession stand - "Shortstop Snacks"
Located at Customer Service behind Section 106
All guests are subject to metal detection screening (walk-through units and/or handheld wands) before gaining access to Spectrum Field. To expedite ballpark entry it is necessary to remove all cell phones, cameras and keys and place them in a screening bowl. Coins, watches, and belts do not have to be removed and bags will always be inspected. A supervisor should be notified if a guest does not wish to walk through a metal detector. Guests with pacemakers should never be hand-wanded. Strollers and wheelchairs will be directed for visual inspection. Guests are encouraged to take prohibited items back to their vehicle. Items left at the gates are not the responsibility of The Threshers.
Parking at Threshers games is $3, Phillies Spring Training is $10, cash only. Handicapped, suites, and season ticket holder parking is in the South lot, off of Drew St. and US 19. General parking is in the grass lot off of Old Coachman Rd. in front of the West gate of the ballpark, at the Carpenter Complex south of the park on Old Coachman Rd., and at the Joe DiMaggio Complex at the North/West corner of Drew St. and Old Coachman Rd.
For the map of seating areas, please click here.
Smoking is prohibited in most areas of the ballpark. Special smoking sections are marked. Smoking is permitted only on the concourse bridge by the right field foul poul and the Tiki Pavilion in left field.
SOUVENIR STORE
The Threshers Souvenir Store, Diamond Outfitters, is located next to the ballpark's west entry, and features hats, apparel and collectibles to satisfy Threshers fans of all ages. Merchandise available 24 hours a day on-line at ThreshersBaseball.com.
THRESHERS DUGOUT
The Threshers (home) dugout is located on the third base side of the field.
TICKET OFFICE HOURS
The Main Ticket office located near the west entry is open Monday-Friday from 10am-4pm, with extended hours for night and weekend games.
TIKI PAVILION
The Frenchy's Tiki Pavilion is located beyond the left field wall. It features a variety of mixed drinks, beer and wine for guests 21 and over. Seats in this section are first-come, first-serve during Threshers season.
Firearms, weapons, knives, tasers and other dangerous or hazardous devices or substances (collectively "weapons") are prohibited at Spectrum Field, unless carried by an on-duty police officer or otherwise expressly approved by The Threshers. Anyone bringing such a weapon to the premises should return it to their vehicle immediately.
* These policies may be amended at any time.

redpajama_set_name: RedPajamaCommonCrawl


I'm heading to JavaOne in October to talk about some of the stuff we've been doing at RBS. The talk is entitled "Balancing Replication and Partitioning in a Distributed Java Database".
Add the numbers ( 7 + 7 ) and SUBTRACT two ?


The City of Dublin has been working on a curb restoration project in several areas of Muirfield. More areas may be affected soon. The city has posted information on this work here. At this time, we do not have any more information other than what is posted on that page.
During street or curb work, mailbox units may be removed and laid on the lawn. Sometimes damage occurs in the process of removing, laying, and replacing the mailbox. Caps can become loose or fall off, trim and support boards could be damaged, or the mailbox could be dented.
If your mailbox is damaged as a result of the curb and paving programs ONLY (read this if your mailbox is damaged by something other than the curb and street maintenance program) contact Jeremy Cooper at the City of Dublin at 614-410-4634. Tell him your name, Muirfield street address, and that your unit was damaged during paving or curb work. Please do not call Mr. Cooper for any reason other than damage that occurred due to paving or curb work.
It is important that you make a report as soon as possible. It is easier to make a claim when the damage is fresh than several months down the road. If you wait too long, it could be questioned whether the damage occurred as a result of the paving company or someone else. If it is determined the damage resulted from someone other than the paving company, the cost of repairing or replacing the mailbox unit will fall on you. Therefore, it is in your best interest to file a claim quickly. All claims for damage must be made by the homeowner (as opposed to the Association office).
Once a damage claim is filed, the city will investigate it. They will utilize photos that the paving company took of your mailbox before construction began. If it is found that the paving company caused the damage to your unit, the city will contact the office. We will repair or replace the unit as needed and bill the city, who in turn will bill the paving company. We won't start work on your mailbox until the city contacts us with an agreement to pay for it.
Again, please call Mr. Cooper only if your damage was done as a result of paving and curb work. Read if your mailbox is damaged by something else or call the office with questions at 614-889-0922.
Political signage must be located within the buildable area of the property.
Please be aware that signs that are found in the common ground or in city right-of-ways are subject to removal.
The office has received some calls about unwanted and sometimes aggressive door to door soliciting this week in Muirfield. One sales pitch that is prevalent is for magazines, which could be a scam.
The city has strict rules about soliciting and we have covered solicitors in length before. To summarize: anyone soliciting must have a city permit, it must be on them, and they must show you the permit if asked. If they do not have a permit (or even if they do) and you feel intimidated, pressured, or if something just does not feel "right", call the police on their non-emergency number at 614-889-1112. The police will run them off.
Do not think you are bothering the police by calling. At best, unwanted solicitors are a nuisance. At worst, they are scammers or are those looking to scout out the area for an opportunity to commit a crime.
Placing flyers in mail slots is not covered under the soliciting policy, nor is anyone who is not soliciting funds or donations plus is disseminating a lawful message (political or religious).


HOME > Media & Publications > Video > [六點達半新聞速報] - 讀 SPEED 唔使洗底都搵到好工!
[六點達半新聞速報] - 讀 SPEED 唔使洗底都搵到好工!
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Make a statement in this new spring necklace!
There are endless ways to wear this long opera necklace! Wrap it 3-4 times around for a simple everyday look, 5 times for a collar length necklace, or 6 times for a fabulous and edgy choker!


text:
Source: Payson Roundup, The (AZ)
Copyright: 2007 The Payson Roundup
Contact:  http://www.paysonroundup.com/
Details: http://www.mapinc.org/media/1523
Author: Marilyn Decker
POINT OF INFORMATION
The "Strange but True" segment in The Rim Review of Jan. 24 contained
the following statement: "The plant that produces marijuana is useful
for many things, including making rope and paper goods. In fact, a
single acre of hemp can produce as much paper as four acres of trees."
To use "marijuana" and "hemp" interchangeably is incorrect. The
industrial hemp plant is not the same as the marijuana plant though
they look similar and come from the same general plant family.
Industrial hemp is indeed extremely versatile and valuable, and could
do much to help the environment by replacing dwindling resources and
avoiding the use of toxins. Unfortunately, our concern about "drugs"
and our apparent inability to distinguish between these two plants
has kept it illegal for development in this country.
Fortunately that is not true elsewhere, so perhaps as more
information becomes available, it will be accepted for its beneficial
uses here also.
Marilyn Decker, Payson
MAP posted-by: Elaine


text:
E-Sports3 months ago
PlayStation Now Lets Users Change Their PSN ID
Sony has officially rolled out a new feature that lets Playstation users change their PSN names. The first time a user changes the PSN name, it's free, but...
'Rick and Morty' Co-Creator to Release Video Game, 'Trover Saves the Universe'
Rick and Morty co-creator Justin Roiland has transferred the vulgarness of his hit show into a new VR video game titled, Trover Saves the Universe. Posted to Playstation Europe's YouTube...
Apex Legends Details Its Season One
Apex Legends has revealed details of its upcoming Season One and accompanying Battle Pass. Season One, titled Wild Frontier, features new legends, new items and and special events. Buying...
Google Patents Controller For Their Upcoming Gaming Console
In June of last year, Google announced that they are working on developing a gaming console, called Yeti. In February, Google held an event at the Game Developers Conference,...
NBA 2K Pro-Am Team Miraculously Wins After Trailing By 15 With 30 Seconds Left
Check out this video, which features a pro-am team from NBA 2K losing by 15 points with 30 seconds left. With a series of steals and...
Sony's PS4 Remote Play Comes to iPhone and iPad
Remote Play for Sony devices has been released as early as October 2014, but finally, the wait is over for iOS users. The latest update on the PS4 has brought what many...
Warriors Make History By Drafting First Woman In NBA 2K League
The Warriors made (virtual) history by selecting Chiquita Evans, the first woman into the NBA 2K League during Tuesday night's NBA 2K League Draft at Barclays...
Sony Has Discontinued the PlayStation Vita After 8 Years
Sony has announced that it will be discontinuing the PlayStation Vita. After having almost an eight-year run, the portable gaming console will no longer be produced. Launched at a time...
'Pokémon Sword' and 'Shield' Announced For Nintendo Switch
Nintendo and Game Freak have officially announced a next-generation Pokémon for the Switch called Pokémon Sword and Shield, which will serve as the eighth installment of the core titles and the first...
'Fortnite' Adds Lava & Pirates With Season 8 Launch
Epic Games has officially launched season eight of Fortnite, with a whole host of new features coming to the game. A standout feature of season eight is the arrival...


text:
Krist Novoselic Recording Solo Material
Former Nirvana bassist Krist Novoselic told the Tacoma News Tribune that some of the music he has been working on during the recent months may surface later in the year. "I'm still making music. I have my studio, and I'm recording things and I have as much fun as possible," Novoselic said. "But I have that luxury, and I can work on political things. So I can basically just go where my passion takes me." When asked if his solo material might come out, he responded, "You might be surprised, like later in the year. It might all come together. Right now, I'm just doing it for myself, and that's what it's all about." The full story at thenewstribune.com has since been removed.
January 14, 2005 rockdirt News No Comments
Grohl And Novoselic Support Kerry In Vegas
Former Nivana members Dave Grohl and Krist Novoselic made a rare appearance together to support Democratic presidential candidate John Kerry at a early vote rally in Las Vegas, kicking off a two week tour on Tuesday (October 19) at The Stardust Hotel and Casino Parking Lot. Check out pictures from WireImage.
October 23, 2004 rockdirt Photos No Comments
Krist Novoselic Could Be Rehearsing For Wedding Bells
The Tacoma News Tribune reports former Nirvana bassist Krist Novoselic has applied for a marriage license through the Pierce County Auditor's office on February 23rd. The female applicant is listed as 41-year-old artist Darbury Ayn Stenderu. The couple could not be reached for comment, and it was not clear whether the wedding had taken place. The soonest the couple could have legally married, according to the application, was February 26th. "I was surprised that he actually came here," Clerk Stacy MacFarlane said. "I didn't even say anything to him because I didn't want to be one of those fans. … It's my job to be professional and not ask too much." Laughing, she added, "But I wanted to. … They seemed very nice. … They actually looked nice together."
March 9, 2004 rockdirt Uncategorized No Comments
Novoselic Decides Against Running For Office
David Postman of The Seattle Times is reporting that former Nirvana bassist Krist Novoselic has decided against running for lieutenant governor, saying he wants to stay involved in progressive politics but "the whole thing about running a campaign and being a public servant isn't the way to do it." Instead, Novoselic will concentrate on his work with Music for America, a group working to boost voter participation among young people. Read more.
February 15, 2004 rockdirt Uncategorized No Comments
Novoselic To Help Get Out The Vote In Longview
Former Nirvana bassist Krist Novoselic will be present at a free concert in Longview on Friday (February 6) that aims to get young people registered to vote, according to Longview's The Daily News. "I think Democracy is everybody's business," said Novoselic, who grew up near Aberdeen and lives on the Southwest Washington coast. "It's such an exciting year, and there's so much going on in our nation, in our world, and in our state." Read more.
January 31, 2004 rockdirt Uncategorized No Comments
Nirvana's Novoselic Abandons Music Business
After Nirvana disbanded in 1994, bassist Krist Novoselic became politically active and formed several bands including Eyes Adrift — he now says that he's finished with the music business after being unable to achieve any post-Nirvana commercial success. "We came together in 2002 as three musicians who like to play. We came together as three people who shared common life experiences," Novoselic said in the opening of a letter to his fans on eyesadrift.com. "While Eyes Adrift is an artistic success, the commercial side is anything but successful. As far as the music industry goes, I quit. I can't deal. I can't read the magazines, listen to the radio or watch music television without feeling like I've just come in from outer space. I just don't get it and I probably never did. My lot in life is that every band I've ever been in just falls apart. That hurts but I've got a thick hide from years of conditioning. Now please take note that I haven't quit music, I've just quit the business." While Novoselic does not specify what he will do in the future, he does hint that he will continue to be politically active. "You'll all hear about my plans soon enough, he says. "If you've been following my politics, you know that I will continue to work for inclusion, fairness and freedom."
August 1, 2003 rockdirt Uncategorized No Comments
Eyes Adrift Fit Together Well Says Kirkwood
Jeff Niesel of the Cleveland Plain Dealer caught up with Eyes Adrift singer-guitarist Curt Kirkwood, who says his new band is a good team with former Nirvana bassist Krist Novoselic and former Sublime drummer Bud Gaugh. "We fit together well," Kirkwood said. "I don't know how we don't get on each other's nerves. We've all been in bands with people who try to get on your nerves. We're all adults and have a good sense of humor. I think that's a good bonding point. I'm finding as we venture forward into the bleak, gray future that humor's going to be important." Cleveland.com has since removed the article.
December 1, 2002 rockdirt Uncategorized No Comments
Krist Novoselic Shrugs Off Nirvana Hype
Former Nirvana bassist Krist Novoselic tells Jane Stevenson of the Toronto Sun all the hype of his former band has its roots in commercialism. "Whatever, it's the new messiah — that's what it is!" commented Novoselic. "It's all Vivendi (who own Universal Records), you know what I mean? That's the kind of push you can get if you're in a big French utility company, that's how it works. So God bless them all, I say." Canoe.ca has since removed the article.
October 29, 2002 rockdirt Uncategorized No Comments
'Eyes Adrift' Is The Rock Equivalent Of 'Jackass'
Joe Price of the Yale Daily News skewered the self-titled debut of Krist Novoselic's band Eyes Adrift, comparing it to Johnny Knoxville's 'Jackass'. Price writes, "The self-titled debut of Eyes Adrift is the rock 'n roll equivalent of 'Jackass,' the one difference being that the players aren't expecting their audience to cringe and think, "I can't believe they just did that." They just honestly embarrass themselves. But to be fair, Eyes Adrift doesn't break any new ground in the territory of really bad. They're just, you know, conventionally bad." Read more.
Eyes Adrift Debut Is 'A Fun-Loving Record'
Former Nirvana bassist Krist Novoselic spoke with Chart Attack about his new group Eyes Adrift and independently released eponymous debut. "It's kind of a fun-loving record," Novoselic said. "I don't think anyone was really uptight during this. We were having a great time. It was really easy and really quick. It's relaxed, 'cause it came together naturally." Chartattack.com has since removed the article.


text:
Expansion of I-405 will affect CSUN commuters
Jocelyn Swartz
Plans to widen the 405 between the 10 and 101 have come to fruition and construction has begun.
The 405 project, or the Sepulveda pass project, as it is referred to, will create a northbound carpool lane, on I-405 between National Boulevard, which is south of Interstate 10, and Greenleaf Street, which is south of US 101.
Cal State Northridge, conveniently located by the three major freeways Interstate 405, US 101 and US 118, enables students from around the Los Angeles area to commute to the college. However, commuters understand the daily difficulty of traffic on the northbound and southbound I-405.
"CSUN is a commuter school so it will just make the commute easier for those who commute to this school," said graduate student Jennifer Marter.
The $1 billion project is being supported by Mayor Antonio Villaraigosa. The project has been a topic of conversation between Caltrans, the mayor and the department of transportation since 2002.
"I think that something needs to be done about the traffic problem, especially the 405, which we usually call the parking lot, and so I completely support the small steps that are being taken to relieve this annoying problem in L.A.," said Breanna Davis, 23.
In 2005, Deputy District Director Ronald J. Kosiniski sent letters to the residents of the areas that would be affected by the development of new on and off ramps, as well as the construction of widening the freeway.
A letter dated Oct. 18, 2005 states, "Any comments or suggestions you may have concerning alternatives to be studied or potential social, economic, and environmental impacts along the I-405 project limits are welcome."
The DOT executed public outreach surveys in 2002 and 2005. The surveys discovered that in 2002, UCLA and Westwood Hills Property Owners Association supported the development of a northbound carpool lane, but in 2005, WHPOA opposed the Montana off ramp closure due to the UCLA traffic in that particular area.
"I've heard that the 405 – 101 interchange is the worst. From experience it's horrible, whatever they can do they should do," Marter said.
The California DOT District 7, which serves the Los Angeles and Ventura Counties, is the district which will see the most projects in the nation.
"It might even relieve some of the accidents," Marter said.
The High Occupancy Vehicle Lane program will be adding carpool lanes to almost every freeway in the area. This $5 billion project is an attempt to accommodate the growth of the area's population and the traffic that has resulted.
Effects to CSUN students and faculty could include the commute during the construction phase, the easier commute after the project is complete or the neighborhood in which some may live.
"The majority of the student body at CSUN commute to school from their homes, unlike a school like UCSB, where they move from their homes to live on campus or in the dorms, so no matter where they are coming from, CSUN will always be a commuter school for this reason," Davis said.
Jocelyn Swartz, Author
Activist Bree Newsome delivers 'awakening' speech
Delicious vegan dining is a Culver City gem
John Debney concert brings Disney magic to CSUN
Tattoo Tuesday: Only Tattoos with Meaning
Weekly Editor's Picks: farmers' market, Beach Boys tribute show, "Purple Rain" screening
Graduate art students live through their masterpieces
TRENDS Fashion Show – A Designer's Cut
Students show support for presidential candidates
Three nights only, Dreamgirls to grace the VPAC stage
Frame Perfect 2016 hosted by CSUN Anime Club brings competitive gaming to CSUN


text:
Turtle Creek es un borough ubicado en el condado de Allegheny en el estado estadounidense de Pensilvania. En el año 2000 tenía una población de 6.076 habitantes y una densidad poblacional de 2,395.8 personas por km².

Geografía
Turtle Creek se encuentra ubicado en las coordenadas .

Demografía
Según la Oficina del Censo en 2000 los ingresos medios por hogar en la localidad eran de $30,057 y los ingresos medios por familia eran $43,975. Los hombres tenían unos ingresos medios de $28,859 frente a los $23,581 para las mujeres. La renta per cápita para la localidad era de $17,552. Alrededor del 11.3% de la población estaba por debajo del umbral de pobreza.

Referencias

Enlaces externos

Boroughs de Pensilvania
Localidades del condado de Allegheny

redpajama_set_name: RedPajamaWikipedia


Strong indication has been provided by International Olympic Committee (IOC) President Thomas Bach today of his willingness to reform the Olympic sports programme as a key dimension of the Olympic Agenda 2020 modernisation drive.
At last month's Olympic Summit in Lausanne, a key step on the road to the IOC Session in Monte Carlo on December 8 and 9 in which final Agenda 2020 decisions will be made, "an event-based rather than a sport-based" approach to the programme was agreed upon.
This would involve trimming the number of events from existing sports in order to add new ones to the programme, so it would not increase the total number of athletes at the Olympic Games.
Speaking today shortly before the Opening Ceremony of the second Summer Youth Olympic Games here in Nanjing, Bach reiterated his support for this idea and expressed his hope that the IOC membership will think likewise.
"We are discussing the procedure for the composition of the programme, because before we speak about sports and disciplines, we need to have flexibility," he said.
"Now we do not have this flexibility because of the 28 sports.
"As long as we have this it doesn't help to speculate on sports and disciplines, but the task and concentration is on changing this procedure.
"Then, once we have have hopefully changed this in December, we can hopefully consider different sports or disciplines.
"I guess and I hope it will not be restricted to one, and that there will be a good variety of sports that we can choose from at the time.
"You have to go one step after the other, but I hope the IOC members will follow this recommendation in December to have more flexibility."
In a reflection of the focus on youth and innovation, the Youth Olympics will feature exhibition events in wushu, roller skating, sport climbing and skateboarding, and it is thought skateboarding in particular has a strong chance of featuring at a future Olympic Games, possibly as soon as at Tokyo 2020.
Bach said he was keen to see how all four disciplines can convey their passion to the youth, and that he was "really interested to see how this experiment works".
Softball and baseball are other sports strongly hoping to be reconsidered, along with squash, after the sports unsuccessfully bid to return to the Olympic programme during the IOC Session in Buenos Aires last September, where instead wrestling was returned after its removal earlier in 2013.
Another subject which is under discussion as part of Olympic Agenda 2020 is the Youth Olympics itself and, after hefty praise for Nanjing 2014, Bach did imply that changes could be made.
"We are now 100 per cent concentrated on making the Youth Olympics an outstanding success," he said.
"Then after this, we will see what is lined up and we will see what could be done better.
"Nothing in this world is so good that it cannot be tampered with, but this discussion will start only after a successful Youth Olympic Games here in Nanjing."


Shiromani Akali Dal (SAD) president Sukhbir Singh Badal today welcomed the Shiromani Gurdwara Parbandhak Committee's decision to honour three witnesses who staged a relentless battle to ensure life imprisonment to 1984 genocide perpetrator and Congress leader Sajjan Kumar and urged it to also honour all the lawyers who fought this case.
In a statement here the SAD president said the SGPC had in its wisdom taken a decision to honour three witnesses in the case – Bibi Jagdish Kuar, Bibi Nirpreet Kaur and Jagsher Singh initially. "I feel it would be in the fitness of things to honour both the witnesses and lawyers instead of only honouring the witnesses first. I have accordingly made a request to the SGPC president also".
Mr Badal said the Sikh quam was keen that all the lawyers who had prosecuted 1984 butcher Sajjan Kumar as well as those who had assisted the prosecution should be honoured by the apex Sikh body. He said while the role of Mr H S Phoolka, who was the lawyer for complainant Jagdish Kaur was well known, there were other unsung heroes also who needed to be given due recognition by the Sikh 'panth'. "Foremost among these is Senior advocate and CBI special prosecutor R S Cheema who alongwith his daughter Tarannum Cheema won a rare victory for the CBI after 34 years by digging out minutest details and presenting the Daily Dairy of the Raj Nagar police station under whose jurisdiction 34 Sikhs had been butchered in November 1984. Mr Cheema is credited with proving police complicity with the Congress government through the Daily Dairy which claimed that nothing significant had happened in the Raj Nagar area during the period of the mass killings".
The SAD president said similarly Gurbaksh Singh and his team of lawyers – Jarnail Singh and Jasleen Chahal, who had represented Jagsher Singh, had also done yeoman service to the cause of justice for 1984 victims. He said all these lawyers as well as other advocates who had played an important role as part of the prosecution team of the CBI including D P Singh, Hiral Gupta, Manu Mishra and Smrithi Suresh should be given due recognition. He said similarly Mr Phoolka's team of lawyers including Kamna Vohra and Shilpa Dewan should be honoured.
Mr Badal said the Sikh quam was beholden to the witnesses in the case who had borne great hardship and stuck to their stand despite threats and even registration of false cases against Bibi Nirpreet Kaur and her family. "Similarly all the lawyers who represented the CBI as well as the complainants did a stellar job despite destruction of important evidence to ensure exemplary punishment to Sajjan Kumar. Keeping all these factors in mind I request the SGPC to honour all the witnesses as well as lawyers together" he added.


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The weight vest might look like something only for the fittest, most serious athletes out there. But you really don't have to be the next Usain Bolt or training to climb Mount Everest to reap the rewards that weighted vests can bring.
Simply put, weight vests add weight resistance to any activity you are doing, whether you are out running or hiking, working out in the gym or doing fitness classes, practising any number of sports or even cleaning the house at home! As a result, they increase the amount of energy you use to perform such activities (your metabolic cost) so you will burn more calories. They can also increase the strength and power in your muscles and joints, help you accelerate faster and reach higher speeds, and enhance your overall cardiovascular fitness.
One of the great things about a weights vest is that practically anyone can use one. They are easy to put on and clip or strap securely around your waist and will suit complete beginners and regular exercisers right up to athletes training on a daily basis. Plus, they are safe to use, as long as you don't start off with too high a weight too quickly.
The weight usually comes from iron and sand filling inside the vest, with some models having weight packs that you can remove or add as you like to adjust the weight resistance. This is a particularly good feature for those starting out using one as it lets you gradually add more weight to each exercise you do, beginning with a low amount so you don't overdo it and injure yourself and then increasing it in increments as you build up your strength, stamina and overall fitness. Adding just a couple of kilos might not sound like much but we can assure you that you'll feel the difference immediately, and especially 15 minutes or so into your workout!
They are equally good for both cardio and strength based activities, and wearing one during exercises that use only your body weight as resistance means you can increase the load on your body for more intense and effective reps.
Many people who take up a fitness regime find that after a certain period of time they reach a plateau and struggle to get working towards their final fitness goal. In such cases a weight vest can be an excellent solution that helps push you further and on towards your aims.
So put one on next time you hit the gym, go for a fitness class or sports training session, or just when out for a walk. And don't be put off by thinking that these are only for extreme athletes, get yourself a weight vest today and see how big an effect it can have on your fitness.


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Константин Евгеньевич Заклинский (род. 8 мая 1955, Ленинград) — советский, российский артист балета, Заслуженный артист РСФСР (1983).

Биография
В 1974 г. окончил Ленинградское хореографическое училище, с того же года — солист Театра оперы и балета им. С. М. Кирова.

Преподавал дуэтно-классический танец в Вагановском училище. Работал балетмейстером - репетитором  Мариинского театра.С 2015 года – педагог- репетитор ГТОБ «Астана Опера».

Семья
Жена — Алтынай Асылмуратова, балерина, народная артистка Российской Федерации;
 дочь Анастасия (род.1993),выпускница АРБ им.А.Я.Вагановой, артистка балета .

Творчество
Исполнял ведущие партии, в том числе:
 Зигфрид («Лебединое озеро»)
 Дезире; Голубая птица («Спящая красавица»)
 Альберт («Жизель»)
 Солор («Баядерка»)
 Спартак («Спартак»)

Снимался в телефильмах:
 1977 «Галатея» (режиссёр А. А. Белинский) — дружок Дулиттла
 «Тристан и Изольда»
 «Ковбои»
 1986 «Фуэте» (режиссёры В. Васильев, Б. Ермолаев) — Климов
 1986 «Лебединое озеро» (режиссёр Е. Марчерет) — принц Зигфрид
 1987 «Чаплиниана» (режиссёр А. А. Белинский)
 1993 «Грех. История страсти» (режиссёр В. Сергеев)

Награды и признание
 лауреат Международных конкурсов балета (Москва, 1981; Токио, 1984).
 Орден Достык 2 степени (Казахстан) (5 декабря 2018 года).
 Заслуженный артист РСФСР (5 июля 1983 года).

Примечания

Ссылки

Артисты балета Мариинского театра
Выпускники Ленинградского хореографического училища
Преподаватели академии русского балета имени А. Я. Вагановой
Педагоги-репетиторы Мариинского театра


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The Parish Bulletin
SPAGHETTI DINNER
Mark your calendar for the April 6 Spaghetti Dinner!
CHRIST THE DIVINE TEACHER CATHOLIC ACADEMY
Christ the Divine Teacher Catholic Academy is now taking registrations for the 2014-2015 school year. For more information or to schedule a tour, please contact the school at 412-781-7927.
BIBLE, ROSARY & JEWELRY SALE
Bible, Rosary and Jewelry Sale after all Masses the weekend of March 22, 23. This is a very convenient way to get Catholic gift items.
WELCOME, DR. MORTEL!
Please welcome Dr. Rodrigue Mortel—physician, deacon and founder of the Good Samaritans School in St. Marc, Haiti—to our parish this weekend. Dr. Mortel will speak at each mass and a second collection will be taken up to benefit the Good Samaritans School. Our parish is proud to currently sponsor six students at the School; individual parishioners or families sponsor a number of other students. Meet Dr. Mortel following the 9:00 am and 11:00 am Masses this Sunday, March 16, at a Coffee House in the Pastoral Center. This event is sponsored by the Hope for Haiti Committee and the Pastoral Council.
RCIA UPDATE
This weekend, at the 5:00 pm Saturday and 11:00 am Sunday masses respectively, we will celebrate Rites of Sending for Jeffrey Witte, a catechumen, and Mara Baginski, a candidate for the sacraments of Confirmation and Eucharist. This Sunday afternoon, they will travel to St. Paul Cathedral to celebrate a Rite of Election and Call to Continuing Conversion with Bishop Zubik.
During Lent, Jeffrey and Mara enter the third phase of the RCIA process, the "period of purification and enlightenment." This time is centered on spiritual preparation for the Easter sacraments. Jeffrey will celebrate three rites called the Scrutinies, beginning at the 5:00 pm Mass next Saturday.
The season of Lent owes its origins to the efforts of early Christian communities to support their catechumens by joining them in prayer, fasting and penitence. This Lent, may Mara and Jeffrey's presence among us inspire us all to deeper conversion of life!
The baptism preparation session which was originally scheduled for March 24 has been moved to Monday evening, April 7, at 7:30 pm in the parish office. If you wish to have an infant baptized, please make arrangements for the baptism itself with Fr. Ken at least six weeks before your desired date.
LIVING STATIONS
Living Stations for our Parish will be Tuesday Evening, March 25 at 6:30 pm. We extend a special invitation to all of our Religious Education families. Rehearsal for any youth interested in taking part will be Monday, March 24, at 6:30 pm.
APPALACHIA GROUP
Our fundraiser continues this week. You will notice a house in the back of the church with envelopes. Please consider supporting our mission trip this June.
Let us learn from Christ how to pray, to forgive, to sow peace, and to be near those in need. --Pope Francis
A Note from Nancy
Nancy Heil coordinates an extensive Christian service effort for people and families who are poor or homeless. She writes:
It takes a village and one amazing God! On Monday night with temperatures hovering near zero, we had a young married couple and their 3-year-old child waiting hours until near midnight for food and any help we could give them. Though both parents are actively seeking employment, they have absolutely no income and they were placed through Section 8 in an apartment in the projects in East Hills.
Their only possessions were a blow-up mattress, a tiny toy car for their son, Wahid, and some clothes. They received $50 in food stamps and were feeding the boy mainly ramen noodles because "it was the least expensive food item" they could find at the dollar store.
We spent a major part of our week gathering food from meats and dairy products to breads and non-perishables, clothes, dishes, silverware, pots and pans, microwave, coffee pot, TV, toys, full bed, twin bed, sofa, end tables, lamps, a rug, 16 bus passes (for trips to the doctor and job interviews), 15 McDonald's giftcards, a picture of Jesus and a wall-hanging of our Blessed Mother.
This took the involvement of ten households and your parish coming together in a very short period of time. Food, furnishings and clothing were delivered Sunday, and the furniture will be delivered this week.
Having never had toys of his own, when Wahid received his new toys including a "talking" riding car, he refused to let go of it. So when his daddy picked him up to hug him, Wahid squeezed his skinny little legs around his riding car, and up it came with him! His parents are full of tears and prayers.
Thank you to everyone who helped on this one!
Nancy requests the following items:
• washcloths and big towels;
• adult-sized backpacks and duffel bags;
• white Tubesocks.
Food items that are needed include:
• canned vegetables and canned beans—red, black or baked;
• canned fruit;
• canned beef stew.
These groceries go to poor families and to people living in shelters.
Donated items may be left in the bins in the back of church. Gift cards may be left in the small blue gift bag near the bins. We appeal to all to refrain from leaving any items on the porches of 316 and 318 Third St.
CATHOLIC MEN'S FELLOWSHIP
On Saturday, April 12, the 9th Annual Gathering of Catholic Men will take place at the A.J. Palumbo Center. Pre-registration is $40 and event day registration is $50. College or high school student registration is $10. See promotional items in the back of the church. Completed registrations can be placed in the collection basket. For further information contact Eric at 724-766-6116.
FORTY DAYS FOR LIFE
Now through April 13th. Recognizing that "with God, all things are possible," our parish community is joining with hundreds of other cities for this spring's global 40 Days for Life-the largest internationally coordinated pro-life mobilization in history. 40 Days for Life is a peaceful, prayerful-and proven effective-pro-life campaign that has already been embraced by more than half a million people worldwide, saved 8,245 lives from abortion, led to the conversion of 88 abortion workers, and seen 44 abortion facilities close. 40 Days for Life features three components: Prayer & Fasting, Community Outreach, and a 40-Day Peaceful Vigil in front of Planned Parenthood, 933 Liberty Ave, Pittsburgh, every Day from March 5 to April 13 (7 am-7 pm). We encourage everyone to say a daily prayer for the babies during Lent and those able to join us for our turn at the vigil please call Mary Catherine Scanlon 412.781.6550.
LENTEN NULLITY PRESENTATIONS
The Tribunal Office will be providing a 45-minute presentation in each of the four Vicariates of the diocese. The purpose of the talk is to provide information about the nullity process and help those wanting to begin the process to do so by receiving the initial paperwork. The talk is directed toward those who have a desire for adult education regarding this often misunderstood subject. People involved in RCIA as teachers or directors may have a special interest in attending this talk. Registration is not required, but to plan for chairs and refreshments please let us know that you are coming at tribunal@diopitt.org or call 412-456-3033. Presentations at other parishes throughout the diocese are scheduled as follows: March 18, Saint Camillus, New Castle; March 25, Ascension, Ingram; March 31, Saint Fidelis, Meridian; April 2, Saint Thomas More, Bethel Park; April 3, Saint Athanasius, West View; April 8, North American Martyrs, Monroeville; April 10, Ave Maria, Bentleyville. All presentations will begin at 7:00 p.m. and are free.
VINCENTIAN ACADEMY OPEN HOUSE
Vincentian Academy will hold its Spring Open House on Wednesday, March 19, from 7:00 pm to 9:00 pm. A Parent/Student Information Session will take place at 8:00 pm, that same evening in the cafeteria. Register at admissions@vincentianacademy.org for the Entrance Exam that will be held on Saturday, March 22, 2014 at 10:00 am.
JOIN US FOR A MOVIE & A MEAL
The Aquinas Guild invites all women of the parish to a Movie & Meal on Wednesday, March 26. Meet at Waterworks Cinema at 11:30 am for a 12:05 pm showing of "Son of God" then to Panera Bread afterwards for discussion and a bite to eat. Movie ticket is $6.50 and food is on your own. Movie run time is 2 hours 25 minutes. Please RSVP to Sherry Schaffer at (412) 728-5983.
READINGS FOR THE WEEK: MARCH 16, 2014
Sunday: Gn 12:1-4a/2 Tm 1:8b-10/Mt 17:1-9
Monday: Dn 9:4b-10/Lk 6:36-38
Tuesday: Is 1:10, 16-20/Mt 23:1-12
Wednesday: 2 Sm 7:4-5a, 12-14a, 16/Rom 4:13, 16-18, 22/Mt 1:16, 18-21, 24a or Lk 2:41-51a
Thursday: Jer 17:5-10/Lk 16:19-31
Friday: Gn 37:3-4, 12-13a, 17b-28a/Mt 21:33-43, 45-46
Saturday: Mi 7:14-15, 18-20/Lk 15:1-3, 11-32
Next Sunday: Ex 17:3-7/Rom 5:1-2, 5-8/Jn 4:5-42 or 4:5-15, 19b-26, 39a, 40-42
FOR LADIES ONLY!
A prayer service for the women of our parish will be held on the first day of Spring, Thursday, March 20, beginning at 7:00 pm in the church. Please join us to renew, reflect and refresh as we listen to readings and prayers that focus on women. A reception with light refreshments will follow in the Pastoral Center. Bring a family member, friend, or neighbor to enjoy this event with you.
SILVER RING THING
The Silver Ring Thing Catholic Edition is Friday, March 21, and Saturday, March 22! This is open to all students in grades 8-12. Visit silverringthing.com for ticket information.
Our last Sunday for Religious Education is March 23. Our last Tuesday is March 25. We express our deepest gratitude to our catechists and small group leaders.
PARISH LENTEN RETREAT
"BEYOND GOOD FRIDAY: Fasting from Fear and Other Habits that Crowd Christ Out" is the theme of our 2014 parish retreat. The two-session program will allow all to pause and examine your relationship with Christ. Is it being weakened by everyday habits such as worrying, controlling, judging oneself and others, holding onto hurts . . . ? We can all probably add to this list. Join counselor and retreat facilitator Eileen Colianni, M. S. Ed., on Thursdays, April 3 and 10, to learn how to heal such habits, thereby clearing the inner space they consume and enabling us to move into closer communion with the Resurrected Christ. All are welcome and there is no fee. Reservations are not required. The sessions begin at 7 pm in the Duch Pastoral Center.
CPR TRAINING COURSE
Are you prepared to save a life? Learn cardiopulmonary resuscitation (CPR) to potentially save a loved one's life. Help parishioner Ian Gillespie, EMT, earn his CPR Instructor certification by attending this accredited American Heart Association course. Monitor will be present. Sunday, April 13 at 12:00 pm in the Pastoral Center. Preregistration required-limited number of seats, $30 fee payable at time of course. Allow 2 ½ hours. Register by contacting Ian Gillespie at ian@brilliantave.com or 412.973.3268.
MASS INTENTIONS:
Saturday, Vigil of the Second Sunday of Lent, March 15
5:00 pm Robert Tunno (Tunno Family)
Presider: Fr. Kenneth White
Sunday, Second Sunday of Lent, March 16
7:30 am Parishioners of St. Scholastica
9:00 am Pamela McCorkle (Giuffre Family)
Presider: Fr. Sean Hogan
11:00 am Helen McAuliffe (Tish Marsico)
Monday, St. Patrick, March 17
8:30 am James McCaffrey (Dr. & Mrs. Michael Shaughnessy)
Tuesday, Lenten Weekday, March 18
8:30 am Owen Pieper (George & Donna Wehrle)
Wednesday, St. Joseph, March 19
8:30 am Francis Daily (Daily Family)
Thursday, Lenten Weekday, March 20
8:30 am COMMUNION SERVICE
Friday, Lenten Weekday, March 21
8:30 am Robert Hall (Newell Family)
Saturday, Lenten Weekday, March 22
9:00 am Hattie Komorowski (Family)
Saturday, Vigil of the Third Sunday of Lent, March 22
5:00 pm Mary Dee Maloney (Patty Maloney)
Sunday, Third Sunday of Lent, March 23
7:30 am Birthday, Robert Dudas (Mother, Laura & Family)
9:00 am Mary Legath (Jim & Lillian Ranii)
11:00 am Parishioners of St. Scholastica
SAINT SCHOLASTICA PARISH
309 Brilliant Avenue, Pittsburgh, PA 15215
Church Office 412-781-0186; Fax 412-781-4316
parish@saintscholastica.com
World Wide Web: www.saintscholastica.com
Parish Office: Monday-Friday 10:00 a.m.-3:00 p.m.
ST. SCHOLASTICA PROFESSIONAL STAFF
Rev. Kenneth White, M.Th., M.Ed……………....…Ext. 14
frken@saintscholastica.com
Director of Music/Bereavement
Sr. Patricia Baker, C.D.P……………………….…...Ext. 17
patbakercdp@saintscholastica.com
Director of Adult Religious Education & R.C.I.A.
Andrew Bechman, M.Ed……………………….…....Ext. 18
andybechman@saintscholastica.com
Director of Religious Education & Youth Ministry
Jamie Dillon, M.S., M.A., R.R.T…………………....Ext. 20
jamiedillon@saintscholastica.com
Program Director for Religious Education
Gina Musser……………………………………...….Ext. 21
ginamusser@saintscholastica.com
Coordinator of the Protection of Children
Mrs. Mary Swindal…………………………...……..Ext. 10
mswindal@saintscholastica.com
Toll-free Victim's Assistance Hotline 1-888-808-1235
ST. SCHOLASTICA SUPPORT STAFF
Pat Wolfson…………………………………...…….Ext. 10
Office Manager/Parish Accountant
Chrissy Morton ……………………………………..Ext. 24
financeoffice@saintscholastica.com
Tom Galda
maintenance@saintscholastica.com
Bulletin Editor
Amy Condosta
amycondosta@ymail.com
Submissions for bulletin items are due by Noon on Mondays
www.cdtca.org
Sr. Dorothy Dolak S.C.N……………………(412)781-7927
office@cdtca.org
Posted by St. Scholastica Parish


Over the last 15 years, development of chromosome conformation capture (3C) and its subsequent high-throughput variants in conjunction with the fast development of sequencing technology has allowed investigators to generate large volumes of data giving insights into the spatial three-dimensional (3D) architecture of the genome. This huge data has been analyzed and validated using various statistical, mathematical, genomics, and biophysical tools in order to examine the chromosomal interaction patterns, understand the organization of the chromosome, and find out functional implications of the interactions. This review summarizes the data generated by several large-scale high-throughput chromosome conformation capture studies and the functional implications obtained from the data analyses. We also discuss emerging results on factors (both CCCTC binding factor (CTCF) related and CTCF independent) that could contribute to looping interactions.
Recent advances in the field of chromosome conformation capture (3C) and its subsequent advancements like 4C (chromosome conformation capture-on-chip), 5C (carbon copy chromosome conformation capture), and high-throughput chromosome conformation capture (Hi-C) have greatly expanded the general understanding of the three-dimensional spatial arrangement of the genome. Consequently, the notion of a linear chromosomal distribution of various elements of the coding and the non-coding genome is being revisited. This has brought forth a new perspective on how genomic functions such as replication, transcription, and DNA repair would be investigated. Interestingly, the proximity of various regions of the genome, which were otherwise unintuitive, now opens new possibilities by which various aspects of gene regulation would be studied in future. Along with these, herein, we also discuss recent data suggesting the role of telomeres in looping interactions, both near and with interstitial regions of the genome. In addition, factors other than the chromatin-associated protein CCCTC binding factor (CTCF) that could mechanistically contribute to the formation of chromatin loops are also discussed.
Hi-C is a high-throughput NGS (next-generation sequencing)-based version of chromosome conformation capture assay commonly known as 3C . It provides a global view of all chromosomal interactions across the genome. In such experiments, tagged nucleotides are used to capture ligated products after restriction digestion and appropriately diluted ligation. This is followed by sequencing of the captured DNA fragments. The resulting reads represent ligation of fragments both adjacent to each other as well as far apart in the linear genome. A genome-wide two-dimensional contact matrix is generated by dividing the genome or each chromosome into bins of equal distance and then aligning these reads into those bins. Such matrices depict the collective average of the interactions present within the population of cells used for Hi-C studies . There are several other 3C-based assays to look at chromosomal interactions, but the advantage of Hi-C experiments is that they give a global view of all the chromosomal interactions across the genome.
Though we obtain vast knowledge on the biology of chromosomal interactions and genome organization from Hi-C data, there are some drawbacks of the method as well. The Hi-C data, for instance, does not provide much quantitative information on the stability and strength of chromosomal interactions. Most of the reported Hi-C studies so far used asynchronized cells and did not consider the variability that the different cell cycle stages (particularly mitotic phase) would most likely introduce into the chromatin conformation. Several reviews have further described the technical aspects of these 3C-based assays and complimentary microscopy techniques [3–5].
In 2009, Lieberman-Aiden et al. used karyotypically normal GM06990 human lymphoblastoid cells to generate 8.4 million reads that uniquely aligned to the human genome reference sequence in a Hi-C experiment; of these, 6.7 million reads corresponded to long-range contacts between segments of the genome > 20 Kb apart. The long-range contact reads were used to construct genome-wide contact matrices by dividing the genome into 1-Mb-sized bins. This revealed an interesting pattern comprising distinct intra- and inter-chromosomal genomic compartments with contacts that were primarily restricted within compartments .
A few years later, using Hi-C contact matrices of bin sizes ranging from 20 to 100 Kb, about 1.7 billion read-pairs of data were analyzed and genome-wide formation of compartments or topologically associated domains (TADs) in mouse and human-differentiated and embryonic stem (ES) cells was reported . This was supported by work from Jin et al. who studied chromatin interactions in response to transient TNF-alpha signaling in IMR90 primary human fibroblasts by performing Hi-C before and after 1 h TNF-alpha treatment . This gave about 3.4 billion uniquely mapped paired-end reads from multiple biological replicates, among which, approximately 1.4 billion were intra-chromosomal reads.
A slightly different approach termed as in situ Hi-C was used by Rao et al. where DNA-DNA proximity ligation was carried out inside intact nuclei—in situ ligation reduced the chances of spurious contacts due to random ligation in dilute solution . This also yielded a higher resolution of up to 1 Kb bin size and 200- to 1000-fold more contacts. Using the high-resolution contact matrices, it was possible to see many smaller contact domains (sub-TADs) with higher intra-domain contact frequency like the topologically associated domains and other similar small domains discussed in several Hi-C studies (Fig. 1) [6, 9, 10].
Chromosomal interactions across the whole genome noted that the average intra-chromosomal contact probability between pairs of loci in a chromosome decreased consistently with increasing genomic distance (Fig. 2) . Interestingly, this suggested polymer-like behavior of the genome where the three-dimensional distance between pairs of loci increases with increasing genomic distance. Other studies on chromosomal organization via 3C and fluorescence in situ hybridization (FISH) also made similar observations [1, 11]. Even at distances greater than 200 Mb, the average intra-chromosomal contact probability was always more than the average contact probability between different chromosomes (inter-chromosomal), implying the existence of chromosomal territories.
Intriguingly, probabilities of inter-chromosomal contacts show that small, gene-rich chromosomes (chromosomes 16, 17, 19, 20, 21, and 22) preferentially interact with each other. Furthermore, FISH studies also observed these chromosomes to frequently localize to the center of the nucleus [12, 13]. On the other hand, another small but gene-poor chromosome, i.e., 18, was found to interact less with other chromosomes, and FISH studies showed chromosome 18 tends to be located near the nuclear periphery .
Using principal component analysis, each chromosome could be partitioned into two compartments (termed A and B) such that loci within the same compartment had correlated contact profiles. Through this correlation, even loci belonging to different chromosomes were assigned the same compartment, resulting in the whole genome being divided into two spatial compartments such that greater interactions occurred within than across compartments .
It was observed that loci in compartment B had a higher tendency for close spatial localization, suggesting a relatively compact state of chromatin. On the other hand, loci within compartment A showed significant correlation with the presence of genes, higher expression, and chromatin accessibility (DNase I hypersensitivity) and were enriched for activating chromatin marks (H3K36me3). Thus, compartment A could be associated with open, accessible, and actively transcribed chromatin. Together, these suggested open and closed chromatin domains throughout the genome occupy different spatial compartments in the nucleus.
At higher resolution (bin sizes less than 100 Kb), highly self-interacting regions were found to emerge, seen as triangles in the interaction matrix heat map . These regions were termed as topological domains. Topological domains were found to be bound by narrow segments where the chromatin interactions appear to end abruptly. Using a statistic termed directionality index (DI), authors identified 2200 topological domains in mouse ES cells with a median size of 880 Kb that covered ~ 91% of the genome. DI models the difference between a number of upstream and downstream interactions at a given locus along a chromosome, and thereby boundaries of topological domains were detected where there was a significant shift from contact points oriented with upstream vis-à-vis downstream bias. Also, as expected, the frequency of intra-domain interactions was noted to be higher than that of inter-domain interactions.
Consistent with this, fluorescent in situ hybridization (FISH) experiments revealed pairs of loci within a particular topological domain were closer in space than pairs of loci in different topological domains in spite of similar genomic distances between the loci . The genomic regions between the topological domains were defined as either "topological boundary regions" or "unorganized chromatin," depending on their sizes (topological boundary regions: median ~ 0 Kb, 76.3% of the regions < 50 Kb; or unorganized chromatin: median ~ 560 Kb). Moreover, the topological domains correlated with other described components of the genome-like compartments A and B , replication time zones [17, 18], and large organized chromatin K9 modification (LOCK) domains . A large subset of the identified domain boundaries also appeared to mark the transition between LAD (lamina-associated domain) and non-LAD regions in the genome [20, 21].
An in situ Hi-C study using high-resolution contact matrices revealed numerous relatively small contact domains with higher intra-domain contact frequency  like topologically associated domains or other small domains discussed in other Hi-C studies [6, 9, 10].
Interestingly, the in situ Hi-C data revealed six nuclear sub-compartments based on long-range interaction patterns, both intra-chromosomal and inter-chromosomal, using different approaches to clustering. On comparison with compartment A/B , two of the six interaction patterns correlated with loci in compartment A—termed as sub-compartments A1 and A2. These loci were gene dense, harbored highly expressed genes, enriched in activating chromatin marks, and were depleted at the nuclear lamina- and nucleolus-associated domains (NADs). Rest of interaction patterns correlated with loci in compartment B with very different properties than A1 and A2.
The DI data used to identify TADs can vary substantially depending on the sliding window size selected with small window sizes giving smaller TADs and larger ones yielding larger TADs which often nest groups of smaller domains . In fact, reanalysis of the original Hi-C data from which megabase-sized TADs were identified  with a different algorithm using smaller window sizes led to the observation that larger conserved TADs tend to consist entirely of smaller domains. These domains were found to be stable across cell lines and persistent across resolutions, with their boundaries having high enrichment in CTCF binding and activating histone marks .
Chromosomal regions have been perceived as an "equilibrium globule"—a compact and densely knotted configuration originally used to describe a polymer in a poor solvent at equilibrium [23, 24]. An alternative model proposes that polymers, including interphase DNA, can self-organize into a long-lived, non-equilibrium conformation described as "fractal globule" [25, 26]. This dense, compact state is adopted by an untangled polymer as it crumbles into a series of small globules in a "beads-on-a-string" configuration. These beads act as monomers in further rounds of spontaneous crumpling until only a single globule of globules of globules remain.
Lieberman-Aiden et al. analyzed the scaling of contact probability of fractal globule and found that it is close to the contact probability observed from the Hi-C data . The predicted scaling of three-dimensional (3D) distance between pairs of loci based on the fractal globule model is also close to the scaling reported by 3D FISH for genomic distances between 500 Kb and 2 Mb . At a scale of several megabases, the data is consistent with a fractal globule model for chromatin organization. Fractal globule is an attractive model to define chromatin organization since they are free of knots  and in principle consistent with unfolding and refolding, for instance, during gene regulatory events like activation and repression or processes such as replication and recombination.
A strong enrichment of CTCF binding sites was observed at the TAD boundary regions , a property also common with many known insulator or barrier elements [20, 28, 29]. Like a classical boundary element is known to stop the spread of heterochromatin, a clear segregation of the heterochromatin marker H3K9me3 modification was observed within the TAD boundary regions (Fig. 3).
Several studies found TADs to be majorly conserved across cell types in a given organism, suggesting TADs to be stable structures of the 3D genome organization [6, 9, 30]. On the other hand, the smaller scale structures, like sub-TADs, loops, and insulation neighborhoods, all show at least partial variation between different cell lineages, with the variations in their organization appearing to be related with cell type [8, 31–33]. The dynamic chromatin interactions varying across cell types were also enriched for differentially expressed genes [6, 34, 35].
These observations suggest that chromatin organization as TADs is mostly stable across cell types, within which specific structures and dynamic interactions can form to play lineage and context-specific regulatory roles contributing to molecular events associated with differentiation .
Interestingly, the topological domains do not seem to be the consequence of heterochromatin formation as the detected boundaries were present in both pluripotent cells and their differentiated progeny, i.e., before and after heterochromatinization associated with cellular differentiation. Importantly, this implied that the topological domains along with boundaries delineate the endpoints of heterochromatic spreading .
Furthermore, enrichment of chromatin marks associated with promoters and gene bodies and depletion of repressive chromatin marks were detected in the TAD boundaries along with enrichment of housekeeping genes, transcription start sites, and global run on sequencing signal in the boundaries. Together, these suggest a high level of transcriptional activity associated with boundary formation; however, whether boundary formation was a cause or consequence of transcriptional activity was not clear .
Interestingly, Hi-C data also revealed pairs of loci that had significantly stronger interaction than any loci lying between them. These were designated as loops, and can appear within topology domains (discussed above), independently and/or across TADs. Interestingly, chromatin loops were not only conserved among human cell lines but also found to be conserved between mouse and human cells ; chromatin looping interactions were significantly enriched within cis-regulatory elements like active promoters and enhancers while being depleted at inactive TSS or regions with repressive chromatin marks [6–8]. About 30% of chromatin loops brought promoters and enhancers together (versus 7% expected by chance), and genes with promoters associated with loops were more expressed than genes whose promoters were not associated with any loop (sixfold) . Hi-C data analysis also revealed 55% of distal enhancers interact with at least one active promoter, confirming previous observations that promoters and enhancers often form complex networks to regulate transcription [7, 37]. Interestingly, a particular case study showed many genes without any NF-kappaB (p65) binding site in promoters were induced simultaneously by TNF-alpha (which is known to trigger NF-kappaB signaling), possibly due to sharing of overlapping distal interacting regions containing multiple NF-kappaB binding sites .
Somewhat intriguingly, there was little or no change in promoter-enhancer looping interactions at a vast majority of TNF-alpha-responsive enhancers on TNF-alpha treatment. This suggested that in general, promoter-enhancer contacts in untreated cells, which are the existing DNA loops, did not alter upon transient activation or repression of enhancers following treatment. Interestingly, chromatin interactions involving cell type-specific enhancers are variable between cell types indicating context-specific interaction structures. This discrepancy between signal-dependent and cell type-specific enhancers correlates with H3K4me1 chromatin marks, which unlike H3K27me3 remain unchanged upon TNF-alpha treatment . Other studies have also observed pre-existing looping interactions at several loci induced by p53, FOXO3, and glucocorticoid receptors [33, 38, 39].
Analysis of ENCODE ChIP-seq data revealed loci with chromatin loops were typically bound by the insulator protein CTCF (86%) and the Cohesin subunits RAD21 (86%) and SMC3 (87%) . This was consistent with many reports which, using a variety of experimental approaches, suggest a role for CTCF and cohesion in mediating DNA loops [28, 40, 41]. As many of these loops demarcate domains, this observation was also concordant with studies showing CTCF delimits structural and regulatory domains [6, 42, 43]. Furthermore, most peak loci possessed a unique DNA site containing a CTCF binding motif to which all the three proteins (CTCF, Rad21, and SMC3) bind. A vast majority of these motif pairs present in the peak loci were oriented in a convergent manner suggesting that a pair of CTCF motifs in the convergent orientation might be required for the formation of a loop .
Studies by Shay and Wright's groups have demonstrated that telomeres loop to specific loci (within 10 Mb)—a phenomenon called TPE-OLD (telomere positioning effect—over long distances). These studies showed that genes close to the telomere were silenced in young primary cells with long telomeres, but were activated when telomeres became short with cellular aging, an effect that was reversed by re-elongation of telomeres upon exogenous expression of the hTERT (human telomerase) gene. Interactions of the telomere and sub-telomere with chromosomal regions up to 10 Mb away from the telomere end were revealed using modified Hi-C and 3C experiments [44–47]. An important function of such looping showed looping of chromosome 5 sub-telomere resulted in heterochromatic silencing of the telomerase gene in young primary cells . Reports also suggest that several telomere binding proteins like TRF2 and TIN2 can associate with interstitial telomere-like repeats . Such regions of repetitive DNA (often referred to as interstitial telomeric repeats or ITS) may be crucial in forming sub-telomeric loops by recruitment of telomeric factors and structural proteins like Lamins to mediate interaction with telomeres [49, 50].
Though Hi-C has given insights into the functional chromosomal organization, one can argue that this is an average, probabilistic view of chromosomal interactions with much cell-to-cell variation, such that observed domain organization and chromosomal interactions might represent just a fraction of the cells. Some recent studies attempt to address this with Hi-C at the single cell level. In the first such report, pooled data recapitulated the formation of TAD-like structures indicating these domains are robust and form the basis of chromosome conformation in each cell . However, the observed variability in inter-domain contacts suggested significant differences might be possible in the higher order folding of chromosomes. Another single cell study concluded that, though structures of individual TADs and chromosome loops vary substantially from cell to cell, the higher order organizational signatures like the A/B compartments are mostly retained [15, 52]. In addition, it was also noted that LADs and active enhancers and promoters are consistently organized genome-wide in every cell .
The finding that a large fraction of loop boundaries are bound by CTCF and the Cohesin subunits  led to popularization of the extrusion model of loop formation. In this model, a pair of factors (Cohesin), possibly with motor function, can dynamically bind to DNA and move along the DNA in opposite directions extruding the chromatin to form loops in between until they dissociate or stall at a boundary element (CTCF motif) [53–55]. This model largely helps to understand the nested nature of TADs and loops as well as the consequences of CTCF motif deletion and inversion [36, 56]. However, many convergent CTCF motifs exist that do not delineate loops and, interestingly, a considerable fraction of identified loops did not appear to possess any CTCF or cohesion binding sites. Together, these suggest other factors that could be involved in loop formation.
The fact that CTCF motifs can act as boundary elements only when they are oriented in convergent fashion indicate dimerization of CTCF is required for stalling extruding cohesion loops. This indicates that interactions between DNA binding proteins can possibly play a role in mediating loop formation and chromatin interactions by bringing distant genomic loci together. Indeed, DNA binding proteins, YY1 and ZNF143, were found to be enriched in loop loci . Both homodimer and heterodimer formation by proteins bound to distant loci can lead to chromosomal looping interactions. In a somewhat similar context, the telomere binding factor TRF2 has already been implicated in mediating telomeric looping into the extra-telomeric interstitial regions including the TERT loci . The fact that TRF2 can bind to many extra-telomeric sites throughout the human genome implicates possibility of it mediating other looping interactions as well [49, 50, 57, 58].
Apart from proteins, nucleic acids like lncRNAs and secondary DNA structures might also contribute to mediating chromosomal looping interactions. lncRNAs called as activating/enhancer RNAs were found to bind with mediator proteins (MED12 and MED1), and their knockdown led to diminished looping between the ncRNA loci and their target genes and a decrease in mediator binding to the genes [59, 60].
Another interesting context that could support loop formation in a CTCF-independent way comes from the possible involvement of DNA secondary structures such as G quadruplexes. G quadruplexes are typically formed by a stretch of DNA with 3-guanines repeated at least four times at close interval and are reported to be involved in various biological functions across life forms [61–64]. The formation of inter-molecular G quadruplexes raises the possibility that such secondary structure DNA motifs can bring together two distant genomic loci. G quadruplexes have been found to be enriched in DNAse hypersensitive (DHS) promoters as well as DHS cis-regulatory elements [65, 66]. Half G quadruplexes (i.e., two runs of guanines, both containing at least three consecutive Gs) were also found to be enriched at the boundaries of these DHS promoters and cis-elements but were depleted in the vicinity of these sites. Computational analyses showed such half G quadruplexes, one from DHS promoter and one from DHS enhancer, could come together to form G quadruplexes thereby bringing together promoters and enhancers elements via looping . Several studies have reported enrichment of potential G quadruplex forming sequences in fragile genomic regions associated with pathogenic, cancer-causing breakpoints, and structural variations [67–70]. The possible formation of chromosomal loops mediated by G quadruplexes could be one of the contributing factors in increasing the fragility of such chromosomal regions. Disruption of these DNA structure motifs could give a clear idea regarding their roles in mediating functional chromosomal interactions.
Deletion of a TAD boundary, on the other hand, was found to result in spreading of contacts across the deleted region and transcriptional misregulation . Several reports of TAD disruptions leading to pathological outcomes have further consolidated TADs as functional units. Structural variants disrupting CTCF-associated TAD boundaries were noted to allow de novo promoter-enhancer interactions and ectopic gene expression causing limb malformation  and oncogenic transformation . Oncogenic chromosomal rearrangements were also shown to induce aberrant oncogenic expression in AML and medulloblastoma by causing enhancer trafficking where an enhancer acts on a gene other than its normal target due to genomic rearrangements like TAD disruptions [73, 74]. Moreover, it was also reported from Hi-C in prostate cancer cells that generation of smaller TADs due to establishment of additional boundaries and particular cancer-specific interactions within TADs could be associated with oncogenic transformation , and perturbation of CTCF binding by aberrant DNA methylation could cause oncogenic gene expression leading to gliomas by a mechanism similar to "enhancer hijacking" . These pathogenic outcomes based on deregulated enhancer function along with another reporter construct insertion study  implicates that cis-regulatory elements can act in a non-specific manner but within a given TAD in the genome (Fig. 4).
Apart from how abrogation of TADs could lead to pathogenic phenotypes, chromatin looping interactions, even when not associated with a particular TAD, might have significant clinical implications. Recently, an interaction has been reported that might be crucial for TERT reactivation across different cancer types. The two cytosine to thymidine single-point mutations in the TERT proximal promoter (− 146 and − 124 bp from the translation start site), recurrent in several cancers, were found to create a de novo consensus binding motif for ETS transcription factor family [78–83]. GABPA (an ETS transcription factor) was shown to bind to the mutant promoter leading to a long-range chromatin interaction with a region 300 Kb upstream of the TERT promoter. As an effect of this binding, the promoter locus was changed into an open, active chromatin region, eventually enhancing TERT expression which has been widely associated with cancer development [84–86]. In another study, it was shown that telomere looping at the 4q35 locus regulates expression of SORBS2, which is disrupted in the age-associated genetic disease facioscapulohumeral muscular dystrophy .
Many large-scale studies with vast Hi-C data have given us important insights into possible mechanisms of looping, subsequent higher order chromatin organization, and functional significance of domain formation and chromosomal interactions in different processes including transcriptional regulation. Given that these observations encourage a shift in perspective regarding how 3D organization of the genome impacts biological processes, it is of much interest to understand the underlying mechanistic rules governing causation of the folded architecture. Though cohesion and CTCF have been implicated in the formation of chromosomal loops, these proteins are absent in a fraction of loop loci (~ 10–14%) suggesting a role of other factors in determining how chromosomal interactions arise and how these contribute to specific cellular and context-specific functions.
Research fellowships from CSIR (to SSR and AKM) are acknowledged. SC is a recipient of Wellcome Trust/DBT India Alliance Fellowship [grant number 500127/Z/09/Z].
No experimental expenses had been incurred in preparation of this manuscript.
Data sharing is not applicable to this article as no datasets were generated during the current study. All data that was used to generate Fig. 1 can be found in Supplementary information section of Rao et al. .
SSR contributed to the literature review, Hi-C data analysis (for Fig. 2), making of figures, and manuscript writing; AKM contributed to the making of figures and manuscript writing; and SC contributed to the overall conceptualization of the review article and manuscript writing. All authors read and approved the final manuscript.


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Film Review: The Man Who Invented Christmas
Serving as the kindling to start this year's Christmas fire comes, from director Bharat Nalluri by way of Les Standiford's non-fiction book of the same name, the charming, if somewhat slight, Man Who Invented Christmas; a chronicle of the story behind Charles Dickens' beloved novel, 'A Christmas Carol'. Finding fresh life in a tale that […]
by Mike McNulty
in Film, Film Reviews
Serving as the kindling to start this year's Christmas fire comes, from director Bharat Nalluri by way of Les Standiford's non-fiction book of the same name, the charming, if somewhat slight, Man Who Invented Christmas; a chronicle of the story behind Charles Dickens' beloved novel, 'A Christmas Carol'. Finding fresh life in a tale that has been done to death on the screen, Nalluri avoids a straight retelling, and opts instead to pivot the narrative around the story's conception.
Charles Dickens (Dan Stevens) has found himself in a spot of trouble. Following the failure of his previous three books, the author has fallen out of favour with the readers of his time. Having to borrow increasing amounts of money to support his growing family and the expensive renovation on his new, lavish London home, Dickens endeavours to write a new novel in six weeks, to coincide with the festive season.
Finding inspiration in fresh faced, Irish house maid Tara's story of how spirits of the dead come out on Christmas Eve, the seed for Dickens' tentatively titled "Humbug: A Miser's Lament" is planted. And so we embark on a journey, travelling into the depths of Dickens' mind as he sources material from the streets of London, muddles them together with his own past, and scratches them onto parchment.
The film brings to life Dickens' process. When he stumbles into a funeral attended only by a lone figure who utters the phrase now synonymous with this greatest of Christmas works, "humbug," the character for Scrooge is born; a pitch perfect performance by Christopher Plummer. Throughout the film, the rest of the characters that will come to inhabit his novel begin to populate Dickens' life – their fictional existence taking up residence in his real world, following him through the streets of London, and crowding his study.
There is something to be said about Dan Steven's interpretation of Charles Dickens. He injects the author with an energy and charisma that jumps between a frenetic mania as he struggles to meet the deadline, and a self-reflective tenderness that breathes new life into a character who could have very easily travelled down a more stiff, literary route.
Parts of The Man Who Invented Christmas are incredibly twee; the film flits between feeling like a TV-movie and something more cinematic, and the score is your run-of-the-mill Christmas fare – the kind of music pumped full of boisterous pomp, and sprinkled with twinkles that recall John Williams' score from Home Alone. But there is a light-hearted charm to The Man Who Invented Christmas; it's a film that's comforting & spirited. And if you are willing to forgive its faults, it's easy to let that warmth wash over you.
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Q: Как написать SQL запрос по нескольким парам значений бинарного индекса Есть две таблицы: DocType и Doc
У таблицы DocType primary key состоит из дух полей: App и Ext (приложение кот. его открывает и расширение). При чем (ну так получилось) по DocType.Ext однозначно можно определить DocType.App. Индекс по DocType.Ext добавлять нельзя.
В таблице Doc есть оба столбца из DocType.

Картинка может не очень точная, но суть передает
В запрос приходит строка-массив DocType.Ext
Нужно написать select выбирающий все записи из Doc по DocType.Ext.
Проблема: Если написать в лоб
Doc.Ext = ANY(string_to_array(:ФильтрРасширенийДокументов::TEXT,','))

То PostgreSQL использует SeqScan, а не поиск по индексу. Как оптимизировать этот запрос?
Наверное нужно сначала создать временную таблицу в которой будут все пары App и Ext из Doc, которые пришли в фильтре. Но как этот результат запихнуть в where?

redpajama_set_name: RedPajamaStackExchange


The spyder is the most extreme version of the 918 Boxster based on the Cayman GT4 it is lowest and lightest in its category. Its design is distinct and adds to its exclusivity. It has give or take 50 more bhp than the boxster GTS and more torque. Think of it as the RS model of the boxsters.
Porsche have addressed the roof on this new model making it much easier to stow and erect when required and can be used right up to the Spyder's top speed on 180 mph.
Exclusivity is the name of the game with this Boxster. Is there anything else on the market that can really compete with it at the moment? As with the recent trend, due to the exclusivity, premiums are to be expected over Porsche's recommended retail price.
What a great looking car. Exciting times are ahead for Porsche with their prototype electric car making its debut this week.


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Transafe delivers for Omsk
September 12 - Russian logistics provider, Transafe Logistics, has delivered out-of-gauge (OOG) equipment for a hydrogen production unit at Gazprom Neft's Omsk refinery in Russia.
The project, which began in April 2017, involved the transport of 20 OOG units originating from Italy, Romania, Germany, Czech Republic, the Netherlands and China to the refinery in Siberia.
According to Transafe, for the heavier and larger components, the longest distance travelled was 6,500 km.
Transafe used the Russian ports of St Petersburg and Vladivostok, as well as the ports of Ravenna, Italy; Lübeck, Germany; and Liepaja, Latvia, for its transhipment operations.
In total, the project required 85 standard trucks and containers to transport the equipment.
Transafe, which is a specialised logistics provider for mining, power generation, oil and gas, petrochemical and chemical industries, says the Omsk refinery is in the second phase of its modernisation programme that will increase refining volumes and improve the production of light petroleum products.
eng.transafe.ru
OHT expands installation activity
OHT is opening an office in Vejle, Denmark, as a base for the company's wind turbine installation activity.
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Atlas Air Worldwide has ordered four Boeing 747-8F aircraft, in order to meet growing e-commerce and express cargo demand.


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The Mississippi River Flood of 1927 was the most destructive river flood in American history. In the spring of 1927, the river broke out of its earthen embankments in 145 places and inundated 27,000 square miles. Part of its legacy was the forced exodus of displaced sharecroppers, who left plantation life and migrated to Northern cities, adapting to an industrial society with its own set of challenges.
Musically, the Great Migration fueled the evolution of acoustic blues to electric blues bands that thrived in cities like Memphis, Detroit and Chicago becoming the wellspring for R&B and rock as well as developing jazz styles.
THE GREAT FLOOD is a collaboration between filmmaker and multimedia artist Bill Morrison and guitarist and composer Bill Frisell inspired by the 1927 catastrophe.
In the spring of 2011, as the Mississippi River was again flooding to levels not seen since 1927, Frisell, Morrison, and the band traveled together from New Orleans, through Vicksburg, Clarksdale, Memphis, Davenport, Iowa, St. Louis and on up to Chicago.
For the film, Morrison scoured film archives, including the Fox Movietone Newsfilm Library and the National archives, for footage of the Mississippi River Flood. All film documenting this catastrophe was shot on volatile nitrate stock, and what footage remains is pock marked and partially deteriorated. The degraded filmstock figures prominently in Morrison's aesthetic with distorted images suggesting different planes of reality in the story-those lived, dreamt, or remembered.
For the score, Frisell has drawn upon his wide musical palette informed by elements of American roots music, but refracted through his uniquely evocative approach that highlights essential qualities of his thematic focus. Playing guitar, Frisell is joined by Tony Scherr on bass, Kenny Wollesen on drums and Ron Miles on trumpet.
In THE GREAT FLOOD, the bubbles and washes of decaying footage is associated with the destructive force of rising water, the filmstock seeming to have been bathed in the same water as the images depicted on it. These layers of visual information, paired with Frisell's music, become contemporary again. We see the images through a prism of history, but one that dances with the sound of modern music.
'Critic's Pick! Visual poetry, sublime' -The New York Times
'A knockout! -Kenneth Turan, LA Times
'Archival wizard Bill Morrison's film finds lyricism in disaster' -The Wall Street Journal
'This is cinema as art, and a classic.' -LA Weekly
'Fascinating! Required viewing in U.S. history classes throughout the country.' -The Daily Beast
'Hypnotic, playful, wildly evocative...Masterfully assembled; a terrific achievement.' -LA Times
'Four stars! [Conveys] all the terror and pity that modern disaster footage imparts [and causes] its subject to breathe anew. -Time Out New York
'A history lesson so vividly immediate as to resemble a ghostly conjuration.' -The L Magazine
'A remarkable work!' -The Seattle Times
'[An] extraordinary confluence of talents and subject-matter.' -The Telegraph
'[THE GREAT FLOOD] would be a memorable drama even played in total silence. In closeup, it shows trickling streams and rain on cotton plants swelling into torrents; cigar-toting politicians gesticulate reassuringly, and the wealthy making dignified retreats while the impoverished cling to the remains of shacks. Guitarist Bill Frisell's live soundtrack of howling blues chords, Thelonious Monk hooks, country-swing and Old Man River quotes would make a fine concert without a film, too. Put the two together [and] the result moves up another creative and emotional level.' -The Guardian
'A lovely, wordless documentary.' -The New York Times
'Enthralling!' -Now Toronto
Frisell, Bill (composer)
Frisell, Bill (performer)
Oyama, Phyllis (film producer)
Musicians: Bill Frisell (guitar), Ron Miles (trumpet), Tony Scherr (bass, guitar), Kenny Wollesen (drums, vibes).
World War I and the Jazz Age
African American Studies; American Studies; Black and White; Cinema Studies; Communications; Economic Sociology; Environment; Film History; Geography; History (U.S.); Media Studies; Race and Racism
The Great Flood; Bill Morrison; Bill Frisell; 'Mississippi River Flood of 1927'; Mississippi River; music; found footage; archive; Tony Scherr ; Kenny Wollesen ; Ron Miles; "The Great Flood"; Icarus Films; Mississippi delta; blues; ,doc,env; history; science; sociss


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Die Jüdische Gemeinde in Edelfingen, einem Stadtteil von Bad Mergentheim im Main-Tauber-Kreis in Baden-Württemberg, entstand im Mittelalter und existierte bis zur Zeit des Nationalsozialismus.

Geschichte

Historische Entwicklung der jüdischen Gemeinde
Juden gab es in Edelfingen seit dem Mittelalter. Bis 1938 besaß Edelfingen eine signifikante jüdische Gemeinde. Die jüdische Gemeinde Edelfingen besaß die Synagoge Edelfingen, eine Schule und ein rituelles Bad. Ein eigener Religionslehrer war angestellt, der zugleich als Vorbeter und Schochet tätig war. Die Toten der Gemeinde wurden im jüdischen Friedhof in Unterbalbach beigesetzt. Seit 1832 gehörte die Gemeinde zum Bezirksrabbinat Mergentheim.

Opfer des Holocaust
Von den jüdischen Personen, die in Edelfingen geboren wurden oder längere Zeit im Ort wohnten, kamen in der Zeit des Nationalsozialismus die folgenden Personen beim Holocaust nachweislich ums Leben: Berta (Bella) Adler geb. Sulzbacher (1863), Elsa (Else) Adler (1895), Hedwig Adler (1897), Zilli Adler (1895), Fanny Badmann geb. Kahn (1894), Barbara (Babette) Bamberger (1875), Ferdinand (Feidel) Bamberger (1878), Jacob Bamberger (1882), Ida Bierig geb. Weil (1873), Isaak Bierig (1869), Salomon Bierig (1888), Karolina Blömendal geb. Frank (1894), Jette (Jetta) David geb. Ehrenberg (1861), Getta Decker geb. Frank (1893), Rosa Dick geb. Marx (1880), Hanna Ehrlich (1871), Immanuel Ehrlich (1873), Jette Ehrlich (1867), Amalie Frank geb. Sahm (1862) Amalie Frank geb. Levite (1871), Berta Frank geb. Grünfeld (1900), Gertrud Frank (1926), Ruth Frank (1928), Salomon Frank (1936), Getta Freimark geb. Bierig (1879), Paula Goldstein geb. Bierig (1874), Gretchen Grünfeld geb. Sulzbacher (1867), Recha Hellmann geb. Frank (1883), Emanuel Hess (1891), Lydia Hess geb. Rosenheimer (1911), Elly Hirsch (1918), Ricka Hirsch geb. Adler (1882), Rosa Lilienstrauß (1893), Lui Löw (1868), Bassa Markus geb. Gunter (1869), Sofie Oppenheim geb. Frank (1884), Rosa Rothschild geb. Bierig (1877), Berta Schorsch geb. Schloß (1854), Simon Schorsch (1898), Hanni Sieber geb. Michel (1906), Mathilde Steinhäuser geb. Fröhlich (1879), Zerline Stern geb. Ehrlich (1869), Friederike Strauß (1880), Emil Vorchheimer (1895), Manfred Vorchheimer (1935), Sara Vorchheimer geb. Adler (1896) und Paula Wolf (1891).

Literatur
 Klaus-Dieter Alicke: Lexikon der jüdischen Gemeinden im deutschen Sprachraum. Band 1: Aach – Groß-Bieberau. Gütersloher Verlagshaus, Gütersloh 2008, ISBN 978-3-579-08077-2 (Online-Version).

Weblinks

 Jüdische Gemeinde Edelfingen bei Alemannia Judaica

Einzelnachweise

Edelfingen
Gemeinde Edelfingen
Organisation (Bad Mergentheim)