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Posted on December 28, 2018 December 28, 2018 by St. Anne's Living Center
Silent Night – The True Story
The story of Silent Night begins in Salzburg, Austria. A woman there of very little means and no hope of raising her lifestyle or marrying, lived alone. She fell in love with a soldier stationed there. They conceived a child, who was born December 11, 1792. Being an unwed mother with a child, she knew the rejection of society. So she asked the hangman to be godparent to her baby Joseph.
Christmas pageant at St. Anne's
The new mother provided as best she could for Joseph, and realized that a good education was his only hope of a future. The local parish priest recognized his brightness and singing ability. He arranged for Joseph to attend a famous abbey school of Kremsmunster. Young Joseph excelled in his studies, later realizing he had a vocation to the priesthood and entered seminary at 16. Finally, at 22, when he was ready for ordination, Joseph needed a special dispensation since he had no father.
Joseph Mohr was assigned as the assistant pastor at St. Nicholas Church in Oberndorf, 10 miles northwest of Salzburg on the River Salzach. The parish was very modest and the pastor was strict – frugal to say the least. Here, Father Mohr became friends with Franz Gruber. Gruber, also the son of a weaver, had little appreciation for music. Franz was expected to follow in his father's trade. Despite his father's disapproval, Franz began playing the guitar and organ. The parish priest even allowed Franz to practice in Church. His talents were soon recognized, and he was sent to school for formal music training. He eventually settled in Oberndorf, working as a music teacher and raising his family of twelve children. Friends, Mohr and Gruber shared their love of music, and both played the guitar.
On December 23, 1818, Mohr went to visit a mother and her newborn child. On the way back to the Rectory, he paused by the river, meditating on the first Christmas. He wrote a poem of that great event, and called it Silent Night, Holy Night. In his words, he captured the mystery of the incarnation and birth of our Lord: The holy infant Jesus, who is Christ the Savior, Son of God, and Love's pure light, was born of Mary and filled the world with the redeeming grace from Heaven.
On his return to the parish, he received news that the organ was broken. Mice had eaten through the bellows, disabling the wind necessary for the pipes to produce music. Without the funds to repair the organ, he feared Midnight Mass would be silent. He rushed to the Gruber home and shared his problem. He handed Gruber the poem, and asked him to write a melody for guitar instead. Franz Gruber completed the tune in time. At Midnight Mass, 1818, the world heard the first simple song we know as Silent Night. The song was well received, and quickly spread throughout Austria, being called A Tyrolean Carol. Frederick Wilhelm IV , King of Prussia, heard Silent Night at the Berlin Imperial Church and ordered it to be sung throughout the kingdom at Christmas pageants and services.
Ironically, the music gained fame without any credit to its composers. Some thought Michael Haydn, the brother of composer Franz Joseph Haydn, wrote the piece. So the King of Prussia ordered a search. When the king's agents arrived at St. Peter's monastery, inquiring about the composers of Silent Night; Felix, Gruber's son, a student there, approached them and told them the story behind Silent Night. He directed them to his father, who was now the choir master of another parish. From that time on, Mohr and Gruber were credited with Silent Night.Father Joseph Mohr died of tuberculosis at the age of 56, December 4, 1848. Gruber died at 76. Our English translation is attributed to Jane Campbell in 1863, and was carried to America in 1871, in Charles Hutchins Sunday School ymnal .Each year as we prepare to celebrate Christmas, we should take to heart the words of Silent Night and that its message is carried in our own hearts.
Betty Canavan
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Solar Resources: Solar Energy
Categories: Solar Energy
RADIATION SHIELDING:
The biggest challenge we would have, if we launch our settlement near Ganymede, is the Radiation. Just above the Earth's atmosphere, there is some deadly radiation which may cause many problems for the human life nearby. To stop the radiation, we would create an artificial layer of shielding using the metals available in space and earth. We would also use the alloys which would be very useful. To mitigate this challenge there would be some deep space vehicles, which would have a significant protective shielding.
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The layers of the shield shall be uniformly proportionate for better protection. We shall provide our residents with the best radiation shelter to give them the protection and to save the mankind in space.
As we know Titanium absorbs the radiation very efficiently. We would use the alloy of Titanium and Aluminium and many more metals and alloys for constructing the radiation shelter. By using this element, it would make our settlement one of the best protected places for the survival of the mankind.
We would use various shielding materials for building proper radiation shelter. By this the people would be confident to rely on our settlement. We would use the metals which would be of less weight and good strength, because, if we use metals of heavy weight, it would be very difficult for us to manage our settlement. The outermost layer, that is, the solar panels would be 20mm-30mm thick to act as an additional layer of radiation shielding to help us in giving more safety to our residents.
The solar panels would have a protective layer of shield that would help us in protecting our residents from the deadly ultraviolet rays. We would have a thick layer of glass which would protect us from the deadly radiations like UV rays, proton and electron radiation. The materials which would be used are as follows: Shields used:
Tungsten shield
Lead shield
Concrete shield
Bismuth Shield
Titanium shield
The tungsten shield is a good shielding material against the gamma and the X-rays. The X-rays and its mass is less than lead, but when it is of 0.5mm and 1mm, it is more than lead shielding. So we would use it with 0.5mm which is light and can deflect gamma and X-rays. It has a high tensile strength and has a melting point of 3422˚C. Lead shielding Lead shielding can be used to deflect gamma and X-rays just like tungsten but due to its high density and atomic number it can deflect more amount of radiation. It has a melting point of 372˚C which is the reason why we can't use it in the first layer. Concrete shield This type of a shielding would not protect us from the radiation but is useful as it can reduce the amount of radiation passing through it. The metal is made of cement, water and heavy weight aggregates. The melting point of the concrete is 1300˚C. Bismuth shield It is also like concrete shield as it also reduces the radiation in all directions which is a very useful property. It can reduce any type of radiation. It reduces the radiation up to 15.5% but it has a very less melting point of 271˚C. Titanium shield It is a very light material but very strong. It can block the gamma rays, X-rays and electromagnetic rays which can cause problems for the human life. It is very light in weight but can deflect more radiation and has a melting point of 1668°C.
Layers of radiation shielding
Layer-A Concrete 0.5M Layer-B Titanium 1.5M Layers-C Tungsten 0.75M Layer-D Bismuth 1M Layer-E Lead 0.5M
The temperature in our settlement would be maintained by the technicians of NAYSHA who would control the thermal control system as per the needs of the residents. The thermal control system is very useful system which produces the heat in our settlement. As we know that Ganymede is very far from the sun and therefore it is very cold there. That is the reason we planned to keep the thermal control system to maintain the temperature as per the requirement of the residents. The temperature in our settlement would be controlled according to the season so that the people of NAYSHA would feel the comforts like the earth's atmosphere. In this way the people can live a comfortable life in the space. The thermal control system would be powered by the solar energy. If the thermal control system is damaged or does not work properly or needs to be fixed then the in-built heater of NAYSHA would get to work.
The residents would not face any problem regarding the temperature in our settlement. Not only the heater would start to work automatically, but every citizen would be provided a body temperature suit which would help them maintain their body temperature until the thermal control system is repaired. We would provide the people of NAYSHA with an electrified thermal blanket which can keep them warm. These would be all the contingency plans if the thermal control system stops working. It is nearly -193˚C near Ganymede, so we need to produce the heat up to 30˚c in our settlement to keep the people of NAYSHA warm and alive. The energy used to produce the required temperature would be collected from the solar panels on the surface of our settlement. We can even use this thermal control system to melt the rocks or asteroids so that we can extract the ore from the minerals. The thermal control system uses the heat pipes, heater, thermal switches and louvers to transfer the heat to our settlement.
Thermal control system is very useful because it keeps the temperature of our settlement maintained and would prevent the parts of our settlement from getting damaged. The excess heat would be controlled by the thermal rejection and would send the excess heat to the place where the heat is required. This can be mainly used in the industrial section where the excess heat can be transferred from one place to another place so that the temperature in our settlement would be uniformly proportionate throughout our settlement. Asteroids As we all know that space is full of asteroids to overcome from such problems we are having an asteroid capturing system in which we are going to release a sphere from docking system. Then this sphere will divide into two hemispheres. The top hemisphere will divide into four equal parts. This parts will move over the asteroids carrying nets made with plasma ropes. These parts will join at the top of the asteroid as hemisphere. The bottom hemisphere would have strong laser to break the asteroid into pieces. The little amount of substance of an asteroid will sent to base camps for research. If it found useful we use it otherwise we will leave it away from our settlement. In this manner we are going to escape from asteroids.
Dimensions of sphere: Radius: 250m Area: 4πr2 = 4*3.14*(250)2 = 785000m2 Volume: 4/3*π*r3 = 4/3*3.14*(250)3 = 65400000m3
We are going to plasma rope nets of different size depends upon the size of asteroids. Asteroid capturing system:
Stage1: we are going to release a sphere from docking systems of NAYSHA in order to catch an asteroid.
Stage2: This sphere will divide into two equal parts and top part will again divide into four equal parts. These parts will move over the asteroid carrying nets made of plasma ropes (very strong ropes).
Stage3: These parts will join at the top after covering the asteroid with nets as same bottom part. Bottom part has a laser with breaks down the asteroid into simpler pieces.
The most important requirement of humans is water. We planned to have our settlement near Ganymede which is a good resource of water. Ganymede consists of large amount of water under the crust which is made up of ice and is also very thick. The thickness of the crust of Ganymede is of 150 km. The thickness of water level is of 100 km. We would drill to get water from under the crust of Ganymede. But the water we get on Ganymede is saline water and cannot be used for any purpose. It should be purified before the usage. With the help of the robotic drillers we can drill the icy crust and get the water. The process of drilling the icy crust would be the best technique for extracting the water from Ganymede. These robotic drillers would drill the surface and extract the water from under the surface of Ganymede. As the water is salty, we would use the process of distillation for purification. This process would filter the salt water and transport the purified water from the base camps to our settlement. We planned to have the water resource near to our base camp so that it would be easy to transport the purified water from the base camps to our settlement. The water would be transported from the base camp of Naysha to our settlement and would be sent to the residents of NAYSHA through a pipeline. We also have another process for extracting the water and that is by melting the ice with the preserved solar energy. This process can be done by using the inflatable mirror. This mirror reflects the solar energy to a certain place and melts the icy crust and hence we can extract the water. After purifying the water it can be sent to the people of NAYSHA.
As we mentioned above, our location at Ganymede is challenging and would have many problems. One of them is generation of power. We require power for doing our daily activities and many other activities. For generating power we would use three methods:
Nuclear fission
Radioisotope thermoelectric generators
Solar resources: We planned to have solar energy in our settlement for generating electricity. But we need more energy to run our settlement. To overcome this problem we have solar panels which would have the capacity to generate power from the sunlight. The power generated can be used for the domestic purposes in our settlement. But the sunlight would not reach our location always. It receives sunlight nearly 85.8 hours per day and a day on Ganymede is of 171 hours. We planned to use multi junction gallium arsenic solar panels on NAYSHA to generate power. It absorbs the sun light and would convert it into electricity. We planned to use it because of its efficiency of 28%.
Nuclear power plant: We planned to have a nuclear power plant to generate electricity in our settlement. As our location is far from the solar resources we would use a nuclear fission to generate electricity. It would help us in generating electricity. As we would have a base camp on mars, we would find abundant deposits of uranium on mars. So, we would get uranium from mars and use it in the power generation process of NAYSHA. How does nuclear power plant works? It works on the principle of nuclear fission where neutrons would collide with the atoms of uranium. As a result we would get a great amount of energy from this nuclear fission. This energy would be used for the conversion of water to steam. This steam would help the turbines to rotate and these turbines would be connected to the generators. Due to this rotation of turbines with steam, electricity is generated. Advantages of nuclear fission:
Safe to generate electricity,
Pollution free,
Low greenhouse gas emission,
Powerful and efficient,
Reliable,
Easy transportation.
We can produce nearly 4,689,440,000 kHz power per year in this power plant.
Plutonium dioxide radioisotope thermoelectric generators (RTG): We planned to have radioisotope thermo electric generators for generating electricity in our settlement. We would use this method in emergency conditions. This would work with the help of plutonium. We can extract plutonium from the asteroids present in the asteroid belt and some plutonium would be produced as a byproduct of nuclear fission. How it works: It works on the principle of See beck effect where a ray of thermocouples would convert the energy of the heat released by the decay of plutonium into electrical energy. This would be connected to our generators. By this method we would generate electricity in our space settlement.
Advantages of RTG:
Produces high energy radiation,
Tendency to produce radiation decay heat,
Long half-life for continuous energy,
Produces large heat to mass ratio.
Solar Resources: Solar Energy. (2021, Oct 31). Retrieved from http://envrexperts.com/free-essays/essay-about-solar-resources-solar-energy

redpajama_set_name: RedPajamaCommonCrawl


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16-year-old runaway strangled, dumped in field
By Kirk Mitchell
Arapahoe County, beaten, Kimberly Jean Grabin, partially clothed, strangled
Passersby recalled seeing a young girl sitting inside a car speaking with a husky blond man.
Kimberly Jean Grabin, 16
Courtesy Arapahoe County Sheriff's Department
The next morning, on Aug. 18, 1979, a man driving by said a partially clothed body of a young girl lying in a field near Interstate-70 and Gun Club Road about five miles north of Aurora.
Her body was found about a quarter mile south of the highway.
Authorities believe the girl fought with her attacker near the road and was dragged about 30 feet into the field.
She had been beaten and strangled. An autopsy report showed that she had puffed up eyes and bruises on her body.
She had a silver ring on the index finger of her right hand and a gold ring on the index finger of her left hand.
She was partially undressed. A blue blanket was found near the girl's body.
A sketch was done of the girl's face to help identify her, according to a Rocky Mountain News story. She was wearing jeans, a plaid blouse and blue stockings.
Witnesses believed the car seen the night before was either a Chevrolet Nova or Vega.
Categories: Arapahoe County, Colo., Updated
Woman vanished on vacation from Texas to see brother in Littleton
19-year-old stabbed when he opened his car door into someone
stop being to lazy to edit and use spell check!
Comment by Lezlijio — March 6, 2012 @ 9:24 pm
Your comment about using spell check is very ironic ;D
Comment by Guest — March 7, 2012 @ 6:26 am
Very bad grammer Kirk. Slow down and check your work. A man driving buy? The girl was sent to the school in March of 1878? 1878 Kirk? I-70 was not there in 1878.
Comment by Dave — March 6, 2012 @ 9:53 pm
The story has so many twists and turns, the girl was sent to a school in 1878 only to be murdered 101 years later, and still just a teenager. Was she from the past, sent back in time from the future? This is a cold case file for the Twilight Zone…
Comment by Dr. Gillespie — March 6, 2012 @ 11:22 pm
Took a nap, had a crazy dream. I was up in the mountains, but I was a younger girl, a runaway with a car. I see some people near by, but I see a sheriff in his car and he waves to me to follow him like he's going to help me hide out. I get to where he was and there was this secret campsite with all kinds of survival amenities. I see fishing gear and guns. Then, nothing.. That was the end of the dream, dreams like this freak me out. Makes me feel like I'm being called upon by the deceased. A missing cold case file. It was so draining that I feel tired from napping. After looking this up, I believe my dream is a direct link to this case. The similarities are uncanny.. So find out who the sheriff was of those dates. I believe this to be true
Comment by Clara — January 5, 2014 @ 6:07 pm
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Boy stabbed repeatedly in park — 157 comments
Part 1 of 3: Boulder detectives still seek answers in JonBenét Ramsey case — 78 comments
Aurora family killed by intruder with "taste for violence" — 57 comments
Husband admits burying Aurora woman alive — 47 comments
Part 3 of 3: Archived timeline of the JonBenét Ramsey case — 47 comments
"What a disorganized, incoherent article. Does the Post employ any editors?"
— hers1
On Colorado Cold Cases: Murder in 2010 appears to be family feud
"Thanks — I mean, "I" knew I was a genius but it never hurts to hear it again. Yes, an..."
— Will Neal
On Colorado Cold Cases: rising gangsta rap star gunned down at Denver nightclub
"vastly disproportionate amount of white Americans receive food stamps too but Fox or MSNBC forgot to..."
Kirk Mitchell
Kirk Mitchell is a general assignment reporter at The Denver Post who focuses on criminal justice stories. He began working at the newspaper in 1998, after writing for newspapers in Mesa, Ariz., and Twin Falls, Idaho, and The Associated Press in Salt Lake City. Mitchell first started writing the Cold Case blog in Fall 2007, in part because Colorado has more than 1,400 unsolved homicides.
Cases by City
Cases by City Select Category Adams County, Colo. (10) Arapahoe County, Colo. (15) Aspen (2) Chaffee County, Colo. (3) City of Aurora, Colo. (26) City of Boulder, Colo. (8) City of Colorado Springs (31) City of Denver (143) City of Englewood, Colo. (5) City of Fort Collins (3) City of Frederick (1) City of Frisco, Colo. (1) City of Greeley, Colo. (3) City of Idaho Springs (1) City of Lakewood, Colo. (13) City of Littleton, Colo. (2) City of Pueblo, Colo. (2) City of Thornton, Colo. (6) City of Westminster, Colo. (6) Costilla County (1) Douglas County, Colo. (4) El Paso County, Colo. (5) Garfield County (2) General (69) Gilpin County (1) Grand County, Colo. (2) Jefferson County, Colo. (18) Kit Carson County, Colo. (1) La Plata County (1) La Plata County (1) Larimer County, Colo. (3) Mesa County, Colo. (6) Morgan County, Colo. (1) Pueblo County, Colo. (2) Routt County, Colo. (1) Saguache County (2) Summit County, Colo. (1) Updated (19) Weld County (4)
Cold Cases Archives
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About Cold Cases
Denver Post crime reporter Kirk Mitchell unearths and retells the stories of some of Colorado's 1,400 unsolved homicides in hopes of cracking the case.
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Can I buy a Tesla in Nigeria? Is it going to work?
A Tesla is a different car breed that is unique from the normal cars we see every day on Nigerian roads. The name Tesla is gotten from the iconic name of Nikola Tesla, a renowned inventor, and engineer mostly known for his notable contribution to the invention of electricity and other powerful inventions.
3 Reasons You Haven't Being Seeing Tesla Cars On Nigeria Roads
What is a Tesla?
Tesla is an electronically enabled car developed by Tesla Inc, which is popular for creating products and services that run solely on electricity in honour of the popular inventor "Tesla". Tesla has never produced any car that does not run on electricity because this will mean compromising everything the company is known for.
With a Tesla car, the normal hassle of buying fuel to refill your car is eliminated; even the challenge of oiling the car engine is removed. The only concern of a Tesla car is to efficiently charge it, just like you do with your technological gadgets, and we already know how stressful that can be in Nigeria.
So, it is safe to say that Tesla is different from any car you may have ever come across. As a result of its distinctive feature, the price of a Tesla is exorbitant, as the company does not target average persons as its key customers, rather they target extremely influential persons to patronize their products. It is also known that Tesla does not run a cliché warehouse to store its products for sale, rather these cars are sold specifically online. See, class?
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Even as expensive as this car may seem to be, and as "outreaching " it may seem for many Nigerians and the Nigerian environment considering its key feature, there are Tesla Cars in Nigeria. Though they may not be as popular as other saloon or SUV cars that grace the Nigerian roads, they definitely have made their way into Nigeria. According to reports, there are up to four Tesla cars in Nigeria, the car owners do not use them to frequent the road on a daily basis, but once they were seen on the road several, it made rounds on social media.
Can I buy a Tesla in Nigeria?
It is impossible to buy a Tesla car in Nigeria. A Tesla car is not an ordinary car that can be put on display in a showroom. There are a lot of ills happening in society and if a Tesla is ordinarily displayed, it can go missing the next day in Nigeria.
Any Tesla car seen in Nigeria was bought directly from the Tesla Inc in Palo Alto, California, USA. The Tesla currently has about four existing models; the Model S, Model 3, Model X, and Model Y. The first vehicle produced by Tesla Inc, "Tesla Roadster" is no longer being sold by the company.
To even fathom the idea of buying a Tesla in Nigeria, you must have the means to charge the car 24/7. It is no news that there is no constant power supply in Nigeria, so it will be a shame to buy a Tesla and not use it efficiently. Before buying a Tesla, consider the means through which it will be charged, also be ready to pay for the amount of electricity it will consume.
The least expensive Tesla model car is the Model Y, which costs about N14.5 million for the standard range.
The model X SUV on the other hand almost triples the price of the Model Y, do the calculation and gape.
To afford such a car in Nigeria, you have to be living in a highbrow area in the country, where there is hardly any power outage, and even if there is at any time, you should have backup power supplies that can carry the weight.
Can Tesla work in Nigeria?
A Tesla is a car, but the only difference is that it is electronically charged, which is why a lot of people have fears on whether it will work in Nigeria. This article is to douse your fears, because contrary to the popular belief that it cannot work, we want to tell you that it can actually work in Nigeria.
Maintaining the car in Nigeria should not be a problem because it is built in such a way that the parts are not the normal car parts that reduce in life span because of frequent oil changing and fuelling. The only way this car will need maintenance is if it is driven on a regular basis on a Nigerian road. The Nigerian road is mostly compatible with SUV's and saloon cars, but the Tesla is very fragile.
Also, it is impossible to get the spare part of this car anywhere in Nigeria. The spare parts have to be shipped directly from its official store in the USA.
Driving a Tesla in Nigeria can be very exciting, but the owner has to be conscious of a lot of things. It is not a cheap car, and it definitely won't be easy to maintain. If you are looking to learn more intricate details about the Tesla model 3 car in Nigeria, check this out.
The post Can I buy a Tesla in Nigeria? Is it going to work? appeared first on Latest car news, car blog news in Nigeria, car import duties in Nigeria, latest car release.


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Batwoman #16 Review
ComicsDC ComicsReviews
Mara Wood
Batwoman #16
Story by J. H. Williams III and W. Haden Blackman
Art by J. H. Williams III
Review by Mara Whiteside
The Batwoman team has shown their readers that they can handle larger-than-life villains while balancing an emotional volatile story. Williams and Blackman blend the characters effortlessly together into one all-or-nothing story.
Wonder Woman and Batwoman are back in Gotham facing down Medusa and her team of Greek monsters and local villains. The two heroes look upon the wreckage and have different reactions: Batwoman panics at seeing her home being destroyed, and Wonder Woman harnesses her guilt into rage. While there is not a hard and fast rule that Wonder Woman must fight in all Greek-related conflicts, it's easy to see that she feels personally responsible for the situation Gotham is in now.
Medusa is clearly the mastermind of the events in Gotham. The collection of children by Maria (the weeping woman) will be used to bring her mother Ceto to this world. Williams beautifully illustrates the story of Ceto, juxtaposing it with the uncertainty of the children's lives. To insure she can successfully bring her mother to life without interruptions, Medusa calls upon the hydra, a multi-headed beast, to level the city. The dynamic between Wonder Woman and Batwoman shines as they decide how to handle the hydra. Without insult, Diana tasks Kate with hunting down Medusa as she works to kill the hydra.
Rarely do you find a female duo like Wonder Woman and Batwoman. Their evolution from quiet worship to a comfortable team is smooth. As the women become accustomed to working together, they quickly learn each other's strengths and resources. There's no doubt that Wonder Woman and Batwoman make a fantastic team. Let's hope we get to see more of these two in the near future.
Though it's in the middle of a complicated and involved story, Batwoman #16 is an enjoyable read for any Wonder Woman or Batwoman fan (or any comic book fan, for that matter). For those invested in the series, buy it just for Bette's appearance. Her part in this story will likely be an inspiration to both Diana and Kate.
Tags:batwomancomic book reviewdc comicsj.h. williamstalking comicsW. Haden Blackmanwonder woman
Uncanny Avengers # 3 Review
Justice League #16 Review
Mara Wood holds a Ph. D. in School Psychology. Currently, she works for a public school system assessing students for educational placement. Her research focus is comic books and how they can be used in therapy and educational settings. She tends to spend…


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Pregnancy-specific β1-glycoproteins
Development of new strategies and novel drug design to treat trophoblastic diseases and to provide pregnancy success are of crucial importance in maintenance the female reproductive health. Pregnancy specific β1-glycoproteins (PSGs) have long been recognized as trophoblast quality and embryo viability markers. This review article summarizes and discusses advances in 45-year studies on biological roles of PSGs, and structure/function relationships to other fetoplacental proteins as well as implications for drug design with focus on the latest achievements and the challenges for future investigations. PSGs were first discovered with the use of immunochemical methods by Russian scientists Yuri Tatarinov and Vitaliy Masyukevich in the blood serum of pregnant women as early as in 1970. Later, the same protein was isolated from human placental extracts by German researcher Hans Bohn, and discovered in serum of patients with trophoblastic and testicular tumors by several investigators. Combined concentration measurements of placenta-derived circulating proteins including PSGs, human chorionic gonadotropin (hCG), human placental lactogen (hPL), pregnancy-associated plasma protein A (PAPP-A), and proform of eosinophil major basic protein (proMBP) represent the useful tool for evaluating and monitoring pregnancy success and/or complications such as post-implantation embryo viability, pre-eclampsia, extra-uterine pregnancy, and growth retardation. However, integrated biomarker profiling technologies including genetics, epigenetic, omics, systems biology, bioinformatics and molecular imaging approaches are being developed for novel biomarker discovery to increase sensitivity and specificity of quantitative tests for pregnancy success and trophoblastic diseases. Except the role in early embryo implantation, PSGs have been shown to possess immunomodulatory and anti-inflammatory functions, along with ability to regulate vascular morphogenesis and hemostasis. All these functions are, plausibly, mediated through binding to cell surface receptor(s). However, CD9 cell surface glycoprotein belonging to tetraspanin (transmembrane 4) superfamily has been identified as the receptor for murine PSG17 and PSG19, while proteoglycans have been shown to bind murine PSG17, PSG22, PSG23, and human PSG1.
Additionally, human PSG1 occurs to be able to interact with integrins that are receptors for cell adhesion proteins involved in cell-to-cell or cell-to-extracellular matrix attachment, the process underlying cell migration, proliferation, differentiation, invasion, and apoptosis during embryonic development and carcinogenesis. PSGs belong to carcinoembryonic antigen (CEA) family that, in turn, is a part of immunoglobulin (Ig) superfamily and includes the following two subfamilies: (i) CEA-related adhesion molecules (CEACAMs) and (ii) pregnancy-specific beta-1 glycoproteins (PSGs). Genes of CEA family are clustered on chromosome 19 in the region 19q13.2-19q13.4 in humans, and on chromosome 7 and chromosome 1 in mice and rats, respectively. Ten genes encoding human PSGs (PSG1-PSG9, PSG11) and seventeen genes encoding rodent PSGs (psg16-psg32) have been identified to date. Structurally, PSGs represent highly glycosylated proteins with carbohydrate content from 21 to 32%. Molecular weight of their protein moieties varies from about 37 to 49 kDa in humans and from 44 to 54 kDa in rodents; the net molecular weight of PSGs including carbohydrate moieties may reach up to 72 kDa. Proteins of both subfamilies of CEA family, CEACAMs and PSGs, have been shown to possess similar mosaic multi-domain structure that provides their polyfunctional properties. Both human and rodent PSGs compose of a signal peptide and up to 3 Ig-like V(variable)-type and up to 4 Ig-like C(constant)-type domains. The Ig-like V-type domain is characteristic for all proteins of CEA family suggesting their common functions. Another type of structural modules in PSGs are short linear motifs (SLiMs) that represent amino acid sequences typically of 3 to 10 residues in length. Among the SLiMs found in PSGs are integrin-binding RGD tripeptide and proline-rich PxxP motif involved in protein-protein interactions as the site for a protein binding to SH3-domains of various signaling molecules, protein kinases and adaptor proteins. Additionally, in the all human PSGs and in part of rodent PSGs we found YxCx motifs that resemble the part of human alpha-fetoprotein (AFP)-derived biologically active peptide. Biological activities of PSG-derived tetrapeptides (YECE, YVCE, YACS, and YACE), along with CEA-derived pentapeptide (SYKCE) and AFP-derived LDSYQCT heptapeptide were studied by our group in the test of cluster of differentiation (CD) antigen expression by B and T-lymphocytes. We found that the YECE peptide was the most capable in decreasing the expression of CD25, CD71 and HLA-DR antigens by T-lymphocytes from patients with rheumatoid arthritis as compared to healthy donors. Additionally, this peptide stimulated the expression of apoptosis-inducing receptor CD95 and its ligand, CD95L, while other peptides had no effects on their expression. We consider all these short peptides derived from fetoplacental proteins such as AFP, PSGs, CEA, and hCG to serve as a basis to design novel peptide-mimetic therapeutic agents to be used in treatment of cancer, immunologic, allergic and infectious diseases, and pregnancy disorders.
For more information about the article, please visit: http://www.eurekaselect.com/147598
Reference: Moldogazieva, NT.; (2017). Pregnancy-Specific β1-Glycoproteins: Combined Biomarker Roles, Structure/Function Relationships and Implications for Drug Design. Current Medicinal Chemistry., DOI: 10.2174/0929867324666161123090554
Bentham Science Publishers
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This shared experience has inspired both organisations to continue our cultural and creative partnership and aim to undertake a further project in March 2018 focusing on the digital and performative elements of this ambitious UK/India collaboration.
"At Think Arts we strive to bring imaginative experiences for children and young people through an engagement with the arts. Ever since I began working at Think Arts, I have been concerned with the lack of high quality creative engagements for young people. While there are some companies that create work for children, the focus is mostly on younger children (ages between 6 and 12). Teenagers are often not within the remit of the target audience for such productions and are sometimes too young for performances created for an adult audience. Both my daughters (aged 3 years apart) had enjoyed the various dance performances we had watched together during our travels, but I was surprised to find that there is no contemporary dance company in India that creates work for young audiences, and had been thinking for a while about what one could do to address this vacuum.
When I watched the work in progress of Teenage Trilogy at Imaginate, I found so many moments in the piece that would resonate with teenagers in India, I wondered if this could indeed be the starting point of a creative engagement with them. Later when I spoke to Christine and other members of Curious Seed, it was clear that we spoke the same language and were both keen to explore ways of working together. I felt that a residency around the Teenage Trilogy would be very useful not only for the teenagers who would directly be working on the project but hopefully will also inspire dancers in India to create work for young audiences. I was excited at the possibilities and couldn't think of a better company than Curious Seed to take the first step with.
I am really glad that we decided to together organise the residency with Christine in Kolkata earlier this month. Although we were able to only dedicate a few days to it, the impact was quite evident at the sharing. It was a visceral process for the teenagers, and the dancers and older people at the sharing were also moved. I believe that if we could develop this collaboration further, we would able to further the impact and indeed reach many more teenagers by sharing the response piece and by inviting them to contribute to the digital collection of teenage voices from around the world".
Curious Seed's new work in development, Teenage Trilogy, is a visceral, affecting and relevant work which evokes the transition from childhood to adulthood that we all must go through presented through live performance, exhibition and digital media. This work has been shaped through dialogue with teenagers, parents and grandparents in Scotland, Denmark, Belgium and Australia, listening to their personal experiences through informal discussions and creative workshopping. We are also working with intergenerational groups in partnership with Tramway (Glasgow) and Horsecross (Perth Theatre) in Scotland, who are the main co-producers of the work.
The residency in October is the catalyst for a legacy project for those involved locally to continue to work together. After the production of Teenage Trilogy has been premiered in Scotland (February 2018), we will return to Kolkata in March to the different communities that Christine previously engaged with, working with the teenagers and dancers to collaborate on the creation of a piece of work in response to their recent experience of the Teenage Trilogy residency and their ongoing engagement with the project. It is planned that the response work created would in future be taken into schools in the region through the ThinkArts network. Teenage Trilogy will tour Scotland in autumn 2018; a filmed version of the piece created in Kolkata will also feature as part of a public showing of other response pieces created by other groups in Scotland.
The work will be led by Christine Devaney who will design and deliver the project in collaboration with Ruchira Das. Joining Christine from Scotland will be David Maxwell, a Glasgow- based visual artist and film maker who has collaborated from the beginning on the research for Teenage Trilogy. Together they will work with two local dance artists and a visual artist.


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Trump, Ham, and Alternative (Attendance) Facts | Righting America
Trump, Ham, and Alternative (Attendance) Facts
Jan 25, 2017 | Answers in Genesis, Ark Encounter, Ark Encounter Attendance, Donald Trump, Ken Ham, Politics, Righting America, TIF Bonds, Williamstown | 0 comments
by William Trollinger
The similarities between Donald Trump and Ken Ham are eerie. Even about attendance.
We have all seen the photos. And they are dramatic. There is no getting around the fact that attendance at the 2009 presidential inaugural – estimated to be 1.8 million – dwarfed the estimated 800,000 at the 2017 presidential inaugural.
credit: Binyamin Applebaum via Twitter (@BCApplebaum)
But the fact that folks in the media and many, many others noticed and commented upon this observable reality infuriated Donald Trump. He got angrier through Inauguration Day, blasting the press while continuing to claim that there were 1.5 million in attendance. Press secretary Spicer continued the attacks on the media while asserting that "this was the largest audience to ever witness an inauguration, period." When pressed to explain Spicer's false claims, Trump aide Kellyanne Conway said that Spicer did not lie but instead presented – in a stunningly memorable phrase – "alternative facts."
And then there's Ken Ham and Answers in Genesis (AiG), who convinced the small town of Williamstown, Kentucky in 2013 to issue $62 million of bonds for the building of Ark Encounter. This is a sweet deal for AiG, given that – as we have reported before – over the next three next decades 75% of the Ark's property taxes will go to repaying these bonds.
How did Ham and AiG seal this deal? By telling Williamstown that in its first year the Ark Encounter would "attract between 1.2m and 2.0m visitors" which will be "followed by annual attendance increases." With this influx of tourists, which would surpass annual visitors to Chicago's Museum of Science and Industry, Williamstown's leaders believed that a building boom would soon follow bringing numerous new restaurants and hotels as well as jobs for local residents. They must have been even more thrilled when, in 2015, Ham and AiG upped the estimated attendance to 1.4m to 2.2m in the Ark's first year.
The Ark opened on July 7, 2016. Almost immediately, observers – including this site – noticed the empty parking lots and the short ticket lines. See these photos from Thursday, July 7, 2016 (opening day) and Saturday, July 23, 2016:
Entrance to Ark beneath Ark structure on morning of Saturday, July 23, 2016 (photo by Susan Trollinger)
Parking lot opposite ticket-booth building on the morning of Saturday, July 23-2016 (photo by Susan Trollinger)
Ticket-booth building and accompanying parking lot on the morning of 7-23-2016 (photo by Susan Trollinger)
Main ticket-booth building at noon on Thursday, July 7, 2016—opening day (photo by Susan Trollinger)
Like Trump, Ham almost immediately went after the critics. In his August 15 post, "Ark Encounter's Impact — Responding to Misinformation," Ham blasted "the anti-God, agenda-driven secular media" for "try[ing] to fulfill their own (negative) prophecies about this Christian ministry" by "spread[ing] false information about the Ark Encounter." While Ham refused to "release daily attendance figures" – claiming that if he did they would "get twisted and misquoted by secularists anyway" – indications are that first-year "attendance will be way beyond the minimum," and closer to 2.2 million.
A la Trump, this is a bold claim – over 2 million visitors in the first year of the Ark – but with no substantive evidence to back it up. But every once in a while attendance numbers slip out:
In a October 26 post advertising the premiere of The Atheist Delusion (a film in which fundamentalist Ray Comfort attempts to prove God's existence to an assortment of atheists) at Ark Encounter, Ham noted that "this world-class themed attraction" had drawn over 400,000 visitors.
In a November 16 interview with the Grant County News, entitled "Ark attendance nearing 500,000," AiG's Mark Looy noted that the Ark had attracted 425,000 visitors and claimed – without evidence – that the Ark is on track to exceed the 1.4m visitor mark by July 2017.
In a December 26 fund-raising plea, Ken Ham boasted that "in just the few months we've been open, almost half a million guests have toured the life-size Ark."
January 7, 2017: Ark Encounter achieves its half-year anniversary and is silent about attendance.
What does all this mean? Will Ham intensify his attacks on those who suggest the Ark is not doing as well as he and Looy have said? And if the Ark does not attract 1.0-1.5 million visitors in the next six months, will AiG offer up some alternative facts?
Who Is Twisting the Truth? | Righting America at the Creation Museum - […] is getting Ham to acknowledge the remarkably generous conditions of the bond issue. But as we noted in a…
Donald and Ken vs. the Media | Righting America at the Creation Museum - […] those who disagree with them. Both have great affection for "alternative facts" – including alternative attendance facts (regarding the…


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#YQLNEIGHBOURS
Meet Kyle Gruninger, New West Theatre veteran currently on tour with "We Will Rock You".
Kyle Gruninger has performed in countless variety shows throughout his musical career.
A graduate of LCI, Kyle is a New West Theatre veteran and frontman of the international touring metal band Incura. His unique vocal abilities have brought him opportunities to work with multi-platinum producers Arnold Lanni (Our Lady Peace), Brian Howes (Nickelback), and more.  Kyle is currently on tour across North America as a lead performer (Commander Khashoggi) in 'We Will Rock You' – a rock musical celebration of Queen.
1) Tell me a bit about why you chose to pursue music.
When I was about 5 or 6 years old I was lucky enough to see The Phantom of the Opera. I became obsessed with the music and the story and would listen to it non-stop. My music obsession spilled over into rock music but I never lost my dramatic theatrical roots. In some ways I didn't choose music, the music chose me.
2) How did you break into the industry?
Growing up in Lethbridge, it wasn't always easy to get my music heard on a national level at the time. A group of us decided to move to Vancouver to see what would happen if we just sacrificed everything for the music. After years of writing, touring, and having absolutely no money, I wrote a song that got some radio attention and through that I met my manager, label, and producer and continued the journey that is being an artist.
3) What is your most marked characteristic?
I have a unique voice. It's a little quirky and strange and I know that. I credit that voice to why people first would pay attention to my music.... I quickly learned people either loved my voice or absolutely hated it, but it's what made me stick out from the millions of other voices trying to do the same thing. I knew that an original sounding voice coupled with a great song was my best way through the music industry weeds.
4) What is your idea of perfect happiness?
Love. All you need is love, as someone much smarter than me once said. I think it all depends on your goals. Everyone's life is different and everyone wants different things, but love is something we all crave. Being around family, friends and people who truly love you is the most perfect thing in the world to me. I feel grateful every day for the friends and family who love me. They gave me the strength and the confidence to go for my dreams.
5) Which living person do you most admire?
My mom, of course. My mother's strength, her heart, everything she tried to instill in me is something that will always inspire and amaze me. Again, she told me I could do and be anything I wanted. Even when life was dark, and difficult she was the light that always kept me going. She led by example, and I'll always admire her for the things she's done and overcome.... all while making my life the best it could be.
6) Which talent would you most like to have (that you don't already)?
I would love to be able to dance. Like, I can kinda dance... but I would have loved to be an incredible dancer. It's the perfect combination of athleticism and artistic expression. Beautiful.
7) What do you consider your greatest achievement?
My wife. The fact that I found someone to love me through this crazy journey is nothing but a miracle. She's my rock and the reason I do what I do.
INSPIRING & ASPIRING: A column from Economic Development Lethbridge
Growing Agriculture Awareness, Brighter Together


Once a year musicians and motorists join forces in Ware's Tudor Square for an afternoon of acoustic music and classic cars.
The event offers plenty of photo opportunities, with both performers and cars making excellent subjects. Sadly, on this occasion the performance area did not offer good sightlines with engineers and officials hanging around in the background. The cars however were a lot more accommodating.
When photographing cars I like to concentrate on design and detail. Features such as badges and instrumentation make for good close-ups.
Shapes and lines also make for good studies, particularly front and rear ends, as well as lighting equipment.
The Cadillac pictured below has some particularly dramatic features.
Other focal points can include engines – especially if they've been kept looking their best, interiors and any period artefacts. Many proud owners will also dress up for the occasion.
And if it happens to rain you can always take advantage of the classic raindrops on paintwork theme!
To find out more about the event photography services I offer please visit my website at www.stevebeeston.co.uk.