text:
Local museums help foster a connection to history
Wetaskiwin and District Heritage Museums offers many historic gems
Providing a link to the community's past, the Wetaskiwin and District Heritage Museum offers many gems that are key features of the museum, or that visitors may not know about.
Several staff and volunteers' favourite aspects of the museum include the Ashoro, Japan exhibit, the Chinese laundry exhibit, a historic barber's pole, and the Women of Aspenland.
"What I found really interesting, in almost every instance, it was personal. And that's the beauty of the museum," said Karen Aberle, executive director and chief curator.
Aberle added, in a person discovering their favourite piece or exhibit in the museum, it is often because they have made a personal connection and with that comes feelings of nostalgia.
"And that's always the beauty of local history," said Aberle.
Aberle says the Women of Aspenland is one of the museum's biggest projects, with a celebratory ceremony held annually, and while some of the recipients are no longer with the community their families attending in their stead also bring that connection and nostalgia to the affair.
"We're all a part of history and make contributions to our community and this story deserves to be told," said Aberle.
The Heritage Museum's playrooms also offer a unique addition to the programming it can offer, says Aberle.
"Those playrooms are a godsend," she added.
Aberle says when the Wetaskiwin and District Heritage Museum moved into its current location approximately 13 years ago staff wanted to ensure there was something special on site geared toward the youth visitors of the museum, including schools tours and summer camps; allowing the children to discover and play on their own terms. "They are invaluable because programming didn't have to be structured all day."
"They don't even know they're learning. They think they're just playing," said Aberle.
However, like other aspects of the museum, the playrooms help reinforce positive connections to the museum that can grow with the youth.
The Wetaskiwin and District Heritage Museum also has multiple upcoming events and exhibits for the public to take in this fall.
The annual Al Lund Memorial Motorbike Ride will take place Sept. 10, "With all proceeds benefiting the Heritage Museum," said Aberle.
The museum will also be a celebration site for Alberta Culture Days, which will take place Sept. 29 and 30, and Oct.1
"This is a partnership between the Heritage Museum, Alberta Culture, the City of Wetaskiwin, the Wetaskiwin Art Club," said Aberle.
More details about the event will be released as they are confirmed.
The Wetaskiwin and District Heritage Museum Youth Network also continues to make progress on a youth created and directed exhibit featuring the weird and strange laws of Wetaskiwin.
"They are currently in the planning stage. They are trucking right along," said Aberle. "They've been given their spot, they'll be in the window.
Aberle says the Wetaskiwin and District Heritage Museum is a place where the staff love their jobs and creating an experience for the community. "This place is a treasure for the community."
amelia.naismith@pipestoneflyer.ca
Millet & District Museum excited to host Pinewood Derby Aug. 26
Alberta and Canada club Labrador Retriever dog shows coming to Lakedell


Mustard is a plant in the cabbage family that is native to Europe and the Mediterranean region. Like other species in the Brassica family, mustard is harvested for its zesty-tasting leaves that are cooked and eaten as a vegetable in summer. Mustard is also grown and harvested for its seeds, which range in color and flavor sharpness depending on variety. Like peppercorns, mustard seed has a long history of use globally and remains one of the most widely traded spices in the world today. In addition to culinary use, mustard seed is used to make heat-producing poultices. Powdered mustard seed is also used as a laundry aid – it helps to break up protein-based stains, such as dried egg yolk.
To shop all of our Mustard seed or for more information about organic Mustard seed, please visit our full Mustard seed page.


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Journals European Heart Journal
https://read.qxmd.com/read/33448291/the-year-in-cardiovascular-medicine-2020-interventional-cardiology
The year in cardiovascular medicine 2020: interventional cardiology.
Fernando Alfonso, Nieves Gonzalo, Fernando Rivero, Javier Escaned
January 15, 2021: European Heart Journal
https://read.qxmd.com/read/33448289/c-reactive-protein-and-clinical-outcomes-in-patients-with-covid-19
C-reactive protein and clinical outcomes in patients with COVID-19.
Nathaniel R Smilowitz, Dennis Kunichoff, Michael Garshick, Binita Shah, Michael Pillinger, Judith S Hochman, Jeffrey S Berger
BACKGROUND: A systemic inflammatory response is observed in coronavirus disease 2019 (COVID-19). Elevated serum levels of C-reactive protein (CRP), a marker of systemic inflammation, are associated with severe disease in bacterial or viral infections. We aimed to explore associations between CRP concentration at initial hospital presentation and clinical outcomes in patients with COVID-19. METHODS AND RESULTS: Consecutive adults aged ≥18 years with COVID-19 admitted to a large New York healthcare system between 1 March and 8 April 2020 were identified...
https://read.qxmd.com/read/33447845/heart-failure-drug-treatment-the-fantastic-four
Heart failure drug treatment: the fantastic four.
Johann Bauersachs
https://read.qxmd.com/read/33444429/illuminating-the-path-from-genetics-to-clinical-outcome-in-brugada-syndrome
Illuminating the path from genetics to clinical outcome in Brugada syndrome.
Pieter G Postema, Roddy Walsh, Connie R Bezzina
https://read.qxmd.com/read/33438022/alcohol-consumption-cardiac-biomarkers-and-risk-of-atrial-fibrillation-and-adverse-outcomes
Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes.
Dora Csengeri, Ngoc-Anh Sprünker, Augusto Di Castelnuovo, Teemu Niiranen, Julie Kk Vishram-Nielsen, Simona Costanzo, Stefan Söderberg, Steen M Jensen, Erkki Vartiainen, Maria Benedetta Donati, Christina Magnussen, Stephan Camen, Francesco Gianfagna, Maja-Lisa Løchen, Frank Kee, Jukka Kontto, Ellisiv B Mathiesen, Wolfgang Koenig, Blankenberg Stefan, Giovanni de Gaetano, Torben Jørgensen, Kari Kuulasmaa, Tanja Zeller, Veikko Salomaa, Licia Iacoviello, Renate B Schnabel
AIMS : There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We assessed the association between alcohol consumption, biomarkers, and incident AF across the spectrum of alcohol intake in European cohorts. METHODS AND RESULTS : In a community-based pooled cohort, we followed 107 845 individuals for the association between alcohol consumption, including types of alcohol and drinking patterns, and incident AF...
https://read.qxmd.com/read/33438004/alcohol-consumption-atrial-fibrillation-and-cardiovascular-disease-finding-the-right-balance
Alcohol consumption, atrial fibrillation, and cardiovascular disease: finding the right balance.
Jorge A Wong, David Conen
https://read.qxmd.com/read/33437997/lipoprotein-a-ldl-cholesterol-and-hypertension-predictors-of-the-need-for-aortic-valve-replacement-in-familial-hypercholesterolaemia
Lipoprotein(a), LDL-cholesterol, and hypertension: predictors of the need for aortic valve replacement in familial hypercholesterolaemia.
Leopoldo Pérez de Isla, Gerald F Watts, Rodrigo Alonso, José Luis Díaz-Díaz, Ovidio Muñiz-Grijalvo, Daniel Zambón, Francisco Fuentes, Raimundo de Andrés, Teresa Padró, José López-Miranda, Pedro Mata
AIMS: Familial hypercholesterolaemia (FH) and elevated lipoprotein(a) [Lp(a)] are inherited disorders associated with premature atherosclerotic cardiovascular disease (ASCVD). Aortic valve stenosis (AVS) is the most prevalent valvular heart disease and low-density lipoprotein cholesterol (LDL-C) and Lp(a) may be involved in its pathobiology. We investigated the frequency and predictors of severe AVS requiring aortic valve replacement (AVR) in molecularly defined patients with FH. METHODS AND RESULTS: SAFEHEART is a long-term prospective cohort study of a population with FH and non-affected relatives (NAR)...
https://read.qxmd.com/read/33428721/a-leucopoietic-arterial-axis-underlying-the-link-between-ambient-air-pollution-and-cardiovascular-disease-in-humans
A leucopoietic-arterial axis underlying the link between ambient air pollution and cardiovascular disease in humans.
Shady Abohashem, Michael T Osborne, Tawseef Dar, Nicki Naddaf, Taimur Abbasi, Ahmed Ghoneem, Azar Radfar, Tomas Patrich, Blake Oberfeld, Brian Tung, Zahi A Fayad, Sanjay Rajagopalan, Ahmed Tawakol
AIMS : Air pollution [i.e. particulate matter with diameter <2.5 μm (PM2.5)] is a risk factor for major adverse cardiovascular events (MACE). While PM2.5 promotes leucopoiesis and atherosclerotic inflammation in experimental models, it is unknown whether this occurs in humans. We tested in humans (a) whether PM2.5 associates with higher leucopoietic tissue activity and arterial inflammation (ArtI), (ii) whether these associations persist after accounting for the effects of potential confounders including socioeconomics, traffic noise, and risk factors, and (iii) whether these tissue effects mediate the association between air pollution and MACE...
https://read.qxmd.com/read/33428713/risk-stratification-in-brugada-syndrome-the-challenge-of-the-grey-zone
Risk stratification in Brugada syndrome: the challenge of the grey zone.
Pietro Delise
https://read.qxmd.com/read/33428708/learning-whether-to-subtract-beta-blockers-it-s-about-time
Learning whether to subtract beta-blockers: it's about time.
Sean van Diepen, Paul W Armstrong
https://read.qxmd.com/read/33428707/effect-of-long-term-beta-blocker-treatment-following-myocardial-infarction-among-stable-optimally-treated-patients-without-heart-failure-in-the-reperfusion-era-a-danish-nationwide-cohort-study
Effect of long-term beta-blocker treatment following myocardial infarction among stable, optimally treated patients without heart failure in the reperfusion era: a Danish, nationwide cohort study.
Anders Holt, Paul Blanche, Bochra Zareini, Deepthi Rajan, Mohammed El-Sheikh, Anne-Marie Schjerning, Morten Schou, Christian Torp-Pedersen, Patricia McGettigan, Gunnar H Gislason, Morten Lamberts
: Listen to the audio abstract of this contribution at https://doi.org/10.1093/eurheartj/ehaa1058. AIMS: We aimed to investigate the long-term cardio-protective effect associated with beta-blocker (BB) treatment in stable, optimally treated myocardial infarction (MI) patients without heart failure (HF). METHODS AND RESULTS: Using nationwide registries, we included patients with first-time MI undergoing coronary angiography (CAG) or percutaneous coronary intervention (PCI) during admission and treated with both acetyl-salicylic acid and statins post-discharge between 2003 and 2018...
https://read.qxmd.com/read/33421053/immune-cell-based-cardiovascular-risk-assessment-spotlight-on-the-neutrophil-lymphocyte-ratio
Immune cell-based cardiovascular risk assessment: spotlight on the neutrophil-lymphocyte ratio.
Hendrik B Sager, Wolfgang Koenig
January 9, 2021: European Heart Journal
https://read.qxmd.com/read/33421051/brugada-syndrome-and-reduced-right-ventricular-outflow-tract-conduction-reserve-a-final-common-pathway
Brugada syndrome and reduced right ventricular outflow tract conduction reserve: a final common pathway?
Elijah R Behr, Yael Ben-Haim, Michael J Ackerman, Andrew D Krahn, Arthur A M Wilde
Brugada syndrome (BrS) was first described as a primary electrical disorder predisposing to the risk of sudden cardiac death and characterized by right precordial lead ST elevation. Early description of right ventricular structural abnormalities and of right ventricular outflow tract (RVOT) conduction delay in BrS patients set the stage for the current controversy over the pathophysiology underlying the syndrome: channelopathy or cardiomyopathy; repolarization or depolarization. This review examines the current understanding of the BrS substrate, its genetic and non-genetic basis, theories of pathophysiology, and the clinical implications thereof...
https://read.qxmd.com/read/33420498/empagliflozin-and-health-related-quality-of-life-outcomes-in-patients-with-heart-failure-with-reduced-ejection-fraction-the-emperor-reduced-trial
Empagliflozin and health-related quality of life outcomes in patients with heart failure with reduced ejection fraction: the EMPEROR-Reduced trial.
Javed Butler, Stefan D Anker, Gerasimos Filippatos, Muhammad Shahzeb Khan, João Pedro Ferreira, Stuart J Pocock, Nadia Giannetti, James L Januzzi, Ileana L Piña, Carolyn S P Lam, Piotr Ponikowski, Naveed Sattar, Subodh Verma, Martina Brueckmann, Waheed Jamal, Ola Vedin, Barbara Peil, Cordula Zeller, Faiez Zannad, Milton Packer
AIMS: In this secondary analysis of the EMPEROR-Reduced trial, we sought to evaluate whether the benefits of empagliflozin varied by baseline health status and how empagliflozin impacted patient-reported outcomes in patients with heart failure with reduced ejection fraction. METHODS AND RESULTS: Health status was assessed by the Kansas City Cardiomyopathy Questionnaires-clinical summary score (KCCQ-CSS). The influence of baseline KCCQ-CSS (analyzed by tertiles) on the effect of empagliflozin on major outcomes was examined using Cox proportional hazards models...
https://read.qxmd.com/read/33417694/professor-anthony-h-gershlick
Professor Anthony H. Gershlick.
Gerry P McCann, Nick P Curzen, Simon G Ray, Nilesh J Samani
https://read.qxmd.com/read/33417692/predicted-benefit-of-an-implantable-cardioverter-defibrillator-the-madit-icd-benefit-score
Predicted benefit of an implantable cardioverter-defibrillator: the MADIT-ICD benefit score.
Arwa Younis, Jeffrey J Goldberger, Valentina Kutyifa, Wojciech Zareba, Bronislava Polonsky, Helmut Klein, Mehmet K Aktas, David Huang, James Daubert, Mark Estes, David Cannom, Scott McNitt, Kenneth Stein, Ilan Goldenberg
AIMS: The benefit of prophylactic implantable cardioverter-defibrillator (ICD) is not uniform due to differences in the risk of life-threatening ventricular tachycardia (VT)/ventricular fibrillation (VF) and non-arrhythmic mortality. We aimed to develop an ICD benefit prediction score that integrates the competing risks. METHODS AND RESULTS: The study population comprised all 4531 patients enrolled in the MADIT trials. Best-subsets Fine and Gray regression analysis was used to develop prognostic models for VT (≥200 b...
https://read.qxmd.com/read/33417682/the-neutrophil-lymphocyte-ratio-and-incident-atherosclerotic-events-analyses-from-five-contemporary-randomized-trials
The neutrophil-lymphocyte ratio and incident atherosclerotic events: analyses from five contemporary randomized trials.
Nicholas H Adamstein, Jean G MacFadyen, Lynda M Rose, Robert J Glynn, Amit K Dey, Peter Libby, Ira A Tabas, Nehal N Mehta, Paul M Ridker
AIMS: The neutrophil-lymphocyte ratio (NLR) is a readily available inflammatory biomarker that may associate with atherosclerosis and predict cardiovascular (CV) events. The aims of this study are to determine whether the NLR predicts incident major adverse cardiovascular events (MACE) and is modified by anti-inflammatory therapy. METHODS AND RESULTS: Baseline and on-treatment NLRs were calculated from complete blood counts among 60 087 participants randomized in the CANTOS, JUPITER, SPIRE-1, SPIRE-2, and CIRT trials to receive placebo or canakinumab, rosuvastatin, bococizumab, or methotrexate, respectively, and followed up for MACE...
https://read.qxmd.com/read/33411926/the-new-european-heart-journal-digital-health-and-innovations-team
The new European Heart Journal Digital Health and Innovations Team.
Panos Vardas, Folkert Asselbergs, Marteen van Smeden
https://read.qxmd.com/read/33411919/dietary-sodium-and-mortality-how-much-do-we-really-know
Dietary sodium and mortality: how much do we really know?
Demilade A Adedinsewo, Amy W Pollak, Rickey E Carter
https://read.qxmd.com/read/33411883/at-the-heart-of-hospital-universitario-central-de-asturias-huca-oviedo-spain
At the Heart of Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain.
Isaac Pascual, Pablo Avanzas, César Morís

redpajama_set_name: RedPajamaCommonCrawl


Description: A mixed voice choir giving between 6 and 8 concerts per year. The repertoire includes sacred music, spirituals, music from the shows, operatic choruses, folk songs and Choral works.
Information for prospective new members: Interested singers are welcome to come to a couple of rehearsals. The ability to read music is desirable but not essential.


text:
Q: linear mixed models: (in)appropriate factor level setup? + rank deficient matrix warning I'm trying to run a mixed-effects model to look at the effects of three treatments on weight in two different groups. I have two questions - I'm really sorry if they're stupid ones. I have next to no experience using R; my supervisor said that I should use RStudio and gave me some code (which...he didn't write either, so he can't really help me with it...and nor can anybody else in my lab.), and I'm uncertain about whether it's doing what I need it to be doing. I'd really appreciate some help.
The first question is about the way my factor levels function in the analysis. My groups and factor levels are set up as follows:
GT<- as.factor(data$GT)
AT <- as.factor(data$AT)
FM <- as.factor(data$FM)
batch <- as.factor(data$BOX)

data$GT<-factor(data$GT,levels = c("WT", "m5"))
data$AT<-factor(data$AT,levels = c("no","yes"))
data$FM<-factor(data$FM,levels = c("no","yes"))

Notably, everyone in FM is also in AT.
(i.e. for both WT and M5, there's ATno/FMno, ATyes/FMno, and ATyes/FMyes, but no ATno/FMyes treatments)
This is the code I've been given:
Weight<- data[,53:58]
Weight.new <- organise_data(data = Weight, groups = group.info,
                                new_var_name = 'Time')
Weight.new$Time <- factor(Weight.new$Time,
                              levels = c('Weight_W8','Weight_W9','Weight_W10',
                                'Weight_W11','Weight_W12', 'Weight_W13'))
Weight.new$Time = as.numeric(Weight.new$Time)
Weight.lmm <- lmer(value ~ GT + AT + FM + Time + GT*FM + AT*FM + GT*AT*FM + (1|BOX), na.action=na.omit,
                      data = Weight.new)
summary(Weight.lmm)

Will this mean that results for ATyes include both ATyesFMTno and ATyesFMTyes? If so, given ATyesFMTno and ATyesFMTyes are different treatment groups they should be looked at separately, right? How should I do this?
Second, two of the interactions (AT * FM and GT * AT * FM) are always dropped with the following warning:
fixed-effect model matrix is rank deficient so dropping 2 columns / coefficients

I understand there can be a number of reasons for this, and that it's not necessarily a fatal kind of thing, but here I'm worried that it's because I'm using the model inappropriately, or have incorrectly specified some terms or something. Is this an appropriate way to have structured things? Again, I'm sorry if this is completely obvious, I'm just a bit inexperienced and overwhelmed and there's nobody else I can ask. Any advice would be extremely appreciated.

redpajama_set_name: RedPajamaStackExchange


Camden Prosecutor Mary Eva Colalillo and Camden County Police Chief Scott Thomson reported a homicide in the city last night.
Camden County Police were dispatched shortly before 9:30 p.m. Tuesday to the Centennial Village Apartments on Centennial Drive in Camden for reports of gunfire in the area.
Officers found the victim, Wallys Sanchez, M/38, of Camden, in the driver's seat of a 1994 Toyota Camry with the engine running. The car was parked in front of building 22.
Sanchez had been shot once and was determined to be dead at the scene.
Anyone with information is urged to contact Camden County Prosecutor's Office Detective Sheron Kee at (856) 225-8539 or Camden County Police Detective John Waida at (856) 757-7420.


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text:
Even with high-dose post-transplant cyclophosphamide (PT-Cy) which was initially introduced for graft-versus-host disease (GvHD) prevention in the setting of HLA-haploidentical transplantation, both acute and chronic GvHDs remain a major clinical challenge. Despite improvements in the understanding of the pathogenesis of both acute and chronic GvHDs, reliable biomarkers that predict their onset have yet to be identified. We recently studied the potential correlation between extracellular vesicles (EVs) and the onset of acute (a)GvHD in transplant recipients from related and unrelated donors. In the present study, we further investigated the role of the expression profile of membrane proteins and their microRNA (miRNA) cargo (miRNA100, miRNA155, and miRNA194) in predicting the onset of aGvHD in haploidentical transplant recipients with PT-Cy. Thirty-two consecutive patients were included. We evaluated the expression profile of EVs, by flow cytometry, and their miRNA cargo, by real-time PCR, at baseline, prior, and at different time points following transplant. Using logistic regression and Cox proportional hazard models, a significant association between expression profiles of antigens such as CD146, CD31, CD140a, CD120a, CD26, CD144, and CD30 on EVs, and their miRNA cargo with the onset of aGvHD was observed. Moreover, we also investigated a potential correlation between EV expression profile and cargo with plasma biomarkers (e.g., ST2, sTNFR1, and REG3a) that had been associated with aGVHD previously. This analysis showed that the combination of CD146, sTNFR1, and miR100 or miR194 strongly correlated with the onset of aGvHD (AUROC >0.975). A large prospective multicenter study is currently in progress to validate our findings.
Extracellular Vesicles as Biomarkers of Acute Graft-vs.-Host Disease After Haploidentical Stem Cell Transplantation and Post-Transplant Cyclophosphamide / G. Lia, C. Di Vito, S. Bruno, M. Tapparo, L. Brunello, A. Santoro, J. Mariotti, S. Bramanti, E. Zaghi, M. Calvi, L. Comba, M. Fascì, L. Giaccone, G. Camussi, E.M. Boyle, L. Castagna, A. Evangelista, D. Mavilio, B. Bruno. - In: FRONTIERS IN IMMUNOLOGY. - ISSN 1664-3224. - 12:(2021), pp. 816231.1-816231.12. [10.3389/fimmu.2021.816231]
Extracellular Vesicles as Biomarkers of Acute Graft-vs.-Host Disease After Haploidentical Stem Cell Transplantation and Post-Transplant Cyclophosphamide
Lia, Giuseppe;C. Di Vito;Bruno, Stefania;M. Tapparo;Brunello, Lucia;Santoro, Armando;J. Mariotti;S. Bramanti;Zaghi, Elisa;M. Calvi;Comba, Lorenzo;Fascì, Martina;Giaccone, Luisa;Camussi, Giovanni;Boyle, Eileen M;L. Castagna;Evangelista, Andrea;D. Mavilio
;Bruno, Benedetto
Even with high-dose post-transplant cyclophosphamide (PT-Cy) which was initially introduced for graft-versus-host disease (GvHD) prevention in the setting of HLA-haploidentical transplantation, both acute and chronic GvHDs remain a major clinical challenge. Despite improvements in the understanding of the pathogenesis of both acute and chronic GvHDs, reliable biomarkers that predict their onset have yet to be identified. We recently studied the potential correlation between extracellular vesicles (EVs) and the onset of acute (a)GvHD in transplant recipients from related and unrelated donors. In the present study, we further investigated the role of the expression profile of membrane proteins and their microRNA (miRNA) cargo (miRNA100, miRNA155, and miRNA194) in predicting the onset of aGvHD in haploidentical transplant recipients with PT-Cy. Thirty-two consecutive patients were included. We evaluated the expression profile of EVs, by flow cytometry, and their miRNA cargo, by real-time PCR, at baseline, prior, and at different time points following transplant. Using logistic regression and Cox proportional hazard models, a significant association between expression profiles of antigens such as CD146, CD31, CD140a, CD120a, CD26, CD144, and CD30 on EVs, and their miRNA cargo with the onset of aGvHD was observed. Moreover, we also investigated a potential correlation between EV expression profile and cargo with plasma biomarkers (e.g., ST2, sTNFR1, and REG3a) that had been associated with aGVHD previously. This analysis showed that the combination of CD146, sTNFR1, and miR100 or miR194 strongly correlated with the onset of aGvHD (AUROC >0.975). A large prospective multicenter study is currently in progress to validate our findings.
acute GvHD; biomarkers; correlation; extracellular vesicles; haploidentical; miRNA; Adult; Aged; Cyclophosphamide; Extracellular Vesicles; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunophenotyping; Male; Middle Aged; Postoperative Care; Prognosis; Proportional Hazards Models; ROC Curve; Transplantation, Haploidentical; Treatment Outcome; Young Adult; Biomarkers
Settore MED/46 - Scienze Tecniche di Medicina di Laboratorio
Settore MED/04 - Patologia Generale
Settore MED/06 - Oncologia Medica
FRONTIERS IN IMMUNOLOGY
https://dx.doi.org/10.3389/fimmu.2021.816231
A:Lia G. et al. - Frontiers in Immunology 2022.pdf


text:
State of the Cloud
State of the Cloud, April 2018
Facebook, Cambridge Analytica and Zuckerberg
Facebook Scandal: the Good News
Spying and Surveillance Shenanigans
Next Step in Cloud Gaming?
Smaller Stories
World Backup Day
By Fergus O'Sullivan (Editor-at-Large)
— Last Updated: 06 Dec'18 2018-12-06T12:57:32+00:00
Welcome to Cloudwards.net's monthly state of the cloud, where we take a look at the most important news stories of the past 30 days as well as look forward a little at the month to come. We focus mostly on tech news, of course, as well as anything related to the cloud in particular; think of it as a recap that will give you the niche knowledge to wow people at parties. Boring parties, but that's just how we roll.
This is the first such article we're running and we hope to do many more in the future. Though there are plenty of excellent news sites out there and we have no wish to replace any of them — trust us, we tried in the past — we do feel that editorially we have plenty to offer. So, strap in and join us as we take a look at what March brought us.
Get our newsletter delivered straight to your inbox every month.
March 2018 was pretty the month of Facebook and the massive meltdown surrounding revelations that Cambridge Analytica, a UK-based market analytics firm, had mined the Facebook data of at least 50 million U.S. voters and targeted ads at them, perhaps even influencing the 2016 U.S. presidential election in favor of The Donald.
Scary stuff. Although U.S. elections are rough, anything-goes affairs when compared to the political process in most other countries, the revelations by whistleblower Christopher Wylie, a co-founder of CA who no longer works there, shook the country, and the rest of the world, to its core.
For months now we've slowly come to accept that Facebook has overdue influence in the world at large after it became clear the power Putin's troll army wields, but now it's clear that it's not only authoritarian strongmen that have it; our own parties and leaders use social media for ill, too.
Mark Zuckerberg, Facebook's CEO, made a public apology (and even took out newspaper ads) and has vowed to make things better. He will be testifying before a U.S. Congressional committee about it, too, though has only deigned to send a stand-in to a UK equivalent.
Zuckerberg's apology, however, rings hollow: his company has been mining and selling people's data for years, though instead of selling it for political ends, the data was used by advertisers. It seems odd to draw the line there: having people spend their hard-won cash on pointless consumer crap they don't need is apparently fine, but apparently influencing the political process isn't.
The role of the media in this whole tragedy is also odd, because they are the ones leading the charge against the political shenanigans, but again don't seem to care much what marketeers do with all the data being hoovered up social media sites. We's like to suggest everyone go the way of Elon Musk, but we won't be deleting our FB page either, because, well, we're no Tesla.
The whole Facebook fracas is in a way, good news: though it took longer than we would have liked, people are now finally paying attention to the crooked antics the company gets up to: already people are deleting their social media profiles and taking greater care in how they behave themselves online. If you're one of those people, make sure to check out our online privacy guide as it will help you get on your way.
The scandal has also spurred developers to create competing standards and protocols that should help keep the web safer for you. One of these options is the use of open protocols and other IMAP tricks that should make social media both easier and safer to use. If you'd like to know more, The Register has a full story on this.
Not that Facebook has some kind of twisted monopoly on spying on people. We all know about PRISM and the Patriot Act, but it seems like soon we can add another acronym to that list: CLOUD. Passed through the backdoor, this new initiative gives U.S. intelligence to yank U.S. citizens' data from cloud servers even overseas, a frightening thought.
Even using a VPN won't save you from this particular problem, meaning that you'll need to use a zero-knowledge provider like Tresorit or Sync.com if you want to keep your files safe from interference.
Not that surveillance is restricted to the interwebz: Chinese police are using state-of-the-art sunglasses to track number plates and even faces, while police in North Carolina are using Google's GPS data to scoop up anyone even near a crime scene. Isn't the modern age just wonderful?
Well, maybe: though gaming-as-a-service (GaaS), or cloud gaming, has taken on an almost chimera-like aspect over the last few years — it has either not happened or happened in a watered-down version — it seems now that finally some serious players are going to be working on it.
Microsoft's gaming division is setting up a project for cloud gaming, while NVIDIA is doing much the same with its GeForce Now project, which currently is in closed beta. While currently we have little else to report, we hope to soon update our article on cloud gaming with the latest and greatest developments.
© Stuff.co.nz
Though plenty happened in tech in March, as you can see, here are few stories we felt deserved a little more love than they got. First up is the news that Spectre and Meltdown have been fixed on any next-gen chips being developed. These fixes are on the hardware level, so hopefully no more slowdowns.
Kim Dotcom, founder of Megaupload and indirectly of MEGA won yet another case in his likely never ending battle against U.S. extradition. The U.S. has wanted the piracy figurehead transported to its jurisdiction for over a decade now, but the larger-than-life Dotcom (he changed his name by deed poll) has successfully resisted until now.
Netflix's original series were banned from the Cannes film festival on a technicality. Though we've all known for years now that Hollywood and its counterparts are terrified of a bit of competition (see the Dotcom story for one example), this decision is once again proof that the old guard will do anything to make sure the upstarts don't get their foot in the door.
Kaspersky Labs will be moving some of its data centers to Switzerland to avoid allegations that the Russian government spies on the company's clientele on the Russia-based servers. Though Russian citizens' data will have to stay stored in the motherland — Putin passed a law expressly forbidding Russians' data from being stored abroad — it's one less worry for foreign customers.
The recently passed U.S. SESTA/FOSTA bill is causing headaches for many cloud services as any content that could be deemed to encourage sex trafficking and the like leaves its hosts on the hook. A few people and companies not in any way related to this rather nasty line of business have already had their content removed as a result.
Last but not least, we ended March on the high note of World Backup Day, a festive day for anyone believes that backing up your data regularly is one of the keys to happiness (we set that bar pretty low on purpose, thankyouverymuch).
Though it's a little earlier to publish any figures, we hope were were able to reach out more people than in the years before and that all of them are safely backed up, preferable using the 3-2-1 rule.
That more or less wraps up Match, if you ask us. Though there's plenty to look forward to this April, we predict the biggest stories will be about the EU's passing of the General Data Protection Regulation (GDPR) in May and how it will affect the internet. This bit of all-encompassing legislation should protect us all a little better and we look forward to learning more about its details.
Do you feel we got it wrong either looking back- or forward? Do you have any thoughts on the stories we've discussed? Let us know in the comments below and, as always, thank you for reading.
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Fergus O'Sullivan
Fergus is the former chief editor and resident curmudgeon of Cloudwards.net. Though he no longer steers the team, he's stuck around to write investigations and news stories (and to annoy newer team members with tall tales). You can contact him at fergus [at] cloudwards.net if you've got a hot lead; anything else will likely get ignored.
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How to make a primordial germ cell.
Gunesdogan U.,Magnúsdóttir E., Surani M.A.
Primordial germ cell specification: a context dependent cellular differentiation event.
Philos. Trans. R Soc. Lond. B. Biol. Sci. 2014 369(1657).
Kong, A., Thorleifsson, G., Frigge, M.L., Masson, G., Gudbjartsson, D.F., Villemoes, R., Magnúsdóttir, E., Olafsdottir, S.B., Thorsteinsdottir, U., and Stefansson, K.
Magnúsdóttir E., Dietmann S., Murakami K., Gunesdogan U., Tang F., Bao S., Diamanti E., Trotter M., Lao K., Gottgens B., Surani M.A.
A tripartite transcription factor network regulates primordial germ cell specification in mice.
Nature Cell Biology, 2013 15 (8):905-915.
Praetorius, C., Grill, C., Stacey, S.N., Metcalf, A.M., Gorkin, D.U., Robinson, K.C., Van Otterloo, E., Kim, R.S.Q., Bergsteinsdottir, K., Ogmundsdottir, M.H., Magnúsdóttir E. , Mishra P.J., Davis S.R., Guo T., Zaidi M.R., Helgason A.S., Sigurdsson M.I., Meltzer P.S., Merlino G., Petit V., Larue L., Loftus S.K., Adams D.R., Sobhiafshar U., Emre N.C.T., Pavan W.J., Cornell R., Smith A.G., McCallion A.S., Fisher D.E., Stefansson K., Sturm R.A., Steingrimsson E.
Grabole N., Tischler J., Leitch H.G., Hackett, J. Kim S., Tang F., Magnúsdóttir E. and Surani M.A.
Prdm14 promotes germline fate and naïve pluripotency by modulating signalling and the epigenome.
Magnúsdóttir E., Gillich A., Grabole N., Surani M.A.
Combinatorial Control of Cell Fate and Reprogramming in the Mammalian Germ Line.
Curr. Opin. Genet. Dev. 2012 22(5):466-474.
Gillich A., Bao S., Hayashi K., Trotter M., Grabole N., Pasque V., Magnúsdóttir E., Surani M.A.
Epiblast Stem Cell-Based System Reveals Reprogramming Synergy of Germ Line Factors.
Cell Stem Cell, 2012 10(4):425-39.
Morgan M.A., Magnúsdóttir E., Kuo T.C., Tunyaplin C., Harper J., Arnold S.J., Calame K., Robertson E.J., Bikoff E.K.
Blimp-1/Prdm1 alternative promoter usage during mouse development and plasma cell differentiation.
Mol. Cell. Biol. 2009 (29):5813-27.
Martins G.A., Cimmino L., Liao J., Magnúsdóttir E., Calame K.
Blimp-1 directly represses il2 and the il2 activator fos, attenuating T cell proliferation and survival.
J. Exp. Med. 2008 (205):1959-65.
Cimmino L., Martins G.A., Liao J., Magnúsdóttir E., Grunig G., Perez K.R., Calame K. Blimp-1 attenuates Th1 differentiation by direct repression of ifng, tbx21 and bcl6 gene expression.
Journal of Immunology, 2008; (181):2338-2347.
Magnúsdóttir E., Kalachikov S., Mizukoshi K., Savitsky D., Ishida-Yamamoto A., Panteleyev A., Calame K.
Epidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1.
Martins G.A., Cimmino L., Shapiro-Shelef M., Szabolcs M., Herron A., Magnúsdóttir E., Calame K.
Transcriptional repressor Blimp-1 regulates T cell homeostasis and function.


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Home»Movies»Movies by Decade»Movies - 1970s
Movies - 1970s Movies - F 4 Mins Read
Fourth Wish, The (1976)
Filmed in Adelaide, the Australian film The Fourth Wish is the story of a 12-year-old boy dying of leukaemia which had already been told as a three-part ABC television series in 1974.
It proved popular enough to be repeated shortly after it was first shown, and the writer, Michael Craig, then rewrote the script into a feature film.
The boy, Sean, is played by 13-year-old Robert Bettles, and it's a fine performance in a role which requires him to convey many things at once. He is supposed to know that he is dying yet not want to admit that he knows. He is to show concern for his father without being cute about it.
In other words, he is supposed to come across as a 12-year-old saint unblemished by sanctimoniousness or awareness beyond his years.
And he does it by understating everything and conveying an essential calmness which works well against the more explosive style of John Meillon who plays Casey, Sean's shift-working father whose wife left him to bring up their son alone eight years ago.
It's not a great life. When the boy is at home at night, he's at work, the landlord is unsympathetic, and the flat is small and dull.
But Sean makes it all worthwhile and Casey can't believe it when the boy, after collapsing at school, is taken to the hospital and diagnosed with leukaemia.
But, painfully, he lets himself be convinced and trains himself not to have too much hope in the drugs and the blood transfusions. Instead, he gives up his job and concentrates on making Sean's last months as happy as possible.
There is a camping trip and a game in which Sean makes three wishes, which Casey promises to fulfil. He wants a dog and to meet both his mother and the Queen.
For Casey this is supposed to be a journey in which he discovers himself, and the script works hard to have it seen that way, but the mechanics are not ingenious enough.
The film's best sequences deal with Casey's efforts to grant the second wish, a meeting with the boy's mother, Connie.
There are no gimmicks in this part of the story, just a well-drawn picture of a realistic relationship and a great performance by Robyn Nevin as Connie, a woman who thinks she is well beyond caring about anything except whisky.
While she pulls herself together long enough to do as Casey asks and not disappoint the boy, the script resists all temptation to become sentimental about her.
Meillon's performance is not so interesting. He has done more than any other actor to define a particular Australian type, the sort of man who masks unworldliness with bombast and would rather pretend to be angry than let anyone see that he's hurt. But he is now letting the character calcify. He has done all that Casey does many times before. The mannerisms are too pat.
But the film's real trouble is in the writing. It doesn't give Casey and Sean enough people to play off. It surrounds them with caricatures so that it is only in the scenes with Connie that the film really comes alive.
It's a complex story given an uncomplicated treatment, which is sad because when it's good, it's very good.
The Fourth Wish was nominated for 5 AFI (Australian Film Institute) Awards, including Best Actress in a Lead Role for Robyn Nevin, Best Screenplay for Michael Craig, Best Achievement in Editing for Gerard Turney-Smith, and Best Actress in a Supporting Role for Anne Haddy.
In the end, the film won one AFI Award, for Best Actor in a Lead Role, for the movie's star John Meillon.
John Meillon
Robert Bettles
Dr Richardson
Michael Craig
Dr Kirk
Anne Haddy
Harbord
Ron Haddrick
Robyn Nevin
Julie Hamilton
Julie Dawson
Edwin Hodgeman
Norman Yemm
Don Crosby
Patcheck
Cul Cullen
Gordon McDougall
Dennis Olsen
Les Foxcroft
Mrs Peterson
Audrey Stern
Mr Peterson
Lionel Williams
Marilyn Allen
Moishe Smith
Bill Collins' Golden Years Of Hollywood 1 9 6 6 - 1 9 9 5 (Australia) Bill Collins has been described as "Mr Movies of Australia". He…
Obsession (1976) High melodrama, creeping insanity and barely contained delirium abound in this dizzying tribute to the high-tension thrillers of Alfred Hitchcock…
Adventures of Gerry Gee, The 1 9 5 9 - 1 9 6 2 (Australia) 5 minute episodes The first regular live children's television show…
Lane End 1 9 7 2 (Australia) 7 x 30 minute episodes Short-lived Aussie serial Lane End debuted on 11 March 1972. Written…
Bev Harrell Alongside Lynne Randell, petite (4' 9") blonde Bev Harrell was one of the most popular female solo singers on the…
Start Living 1 9 6 7 (Australia) 29 x 30 minute episodes This Sunday evening series for young people from Australia's ABC starred…
Flirting (1989) Director John Duigan began the coming-of-age story of Danny Embling in the wonderful The Year My Voice Broke (1987), and continues…
Ryan 1 9 7 3 - 1 9 7 4 (Australia) A twist on the conventional cop dramas, English actor Rod Mullinar…
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Is it theologically precise to say that the christian hearts become the dwelling place of the Holy Trinity? Of course, it is precise, only if the doctrine of the Holy Trinity has its truly right meaning. As it is known, with His incarnation, the Son and Word of God, meaning the Second Person of the Holy Trinity, has not only the divine, but also the human nature. Thus, if anyone who says that the hearts of the Christians become a dwelling place of the Holy Trinity, he ignores the human nature of the Lord and he gives a meaning only to the divine nature, which is not precise to say.
It is wrong, because the Divinity dwells exclusively only in Jesus Christ, as St. Paul the Apostle says « for inhim dwelleth all the fullness of the Godhead bodily»(Col.2,9).Besides, Lord Himself said,<< If a man love me, he will keep my words: and my Father will love him, and we will come unto him and make our abode with him » (John 14,23).Obviously this last phrase means Himself, too. His self is not only God, but also human.
The absolutely precise opinion to say is that the hearts of the christians, become Jesus Christ's dwelling place, as St. Paul the Apostle says « The Christ may dwell in your hearts by faith; that ye being rooted and grounded in love » (Eph.3,17).Thus, it is not wrong to say that the hearts of the Christians become a dwelling place of the Holy Trinity, since Jesus Christ is meant as God and human, of course, according to the words of St. Paul the Apostle above « for inhim dwelleth all the fullness of the Godhead bodily ». Nobody can have God in his heart, unless he lets Jesus Christ live in his heart, because God is not sepatared from Jesus Christ. Only the enemies of the Christ want this separation, without a success as it refered in the second chapter of the Psalms « Let us break their bands asunder and cast away their cords from us. He that sitteth in the Heavens shall laugh: the Lord shall have them in derision » (Ps.2,3-4).
It is impossible for someone to have God in his heart, unless he loves Jesus Christ,because « If any man love not Jesus Christ, let him be Anathema » (1 Cor.16,12).However,who else would dare to think in such a hurry and carelessly that he loves Jesus Christ when He says, « He that hath my commandment, and keepeth them, he is that loveth me: and he that loveth me shall be loved of my Father, and I will love him, and will manifest myself to him » (John 14,21)?
But even, when this word of the Lord « and will manifest myself to him » becomes reality in someone's heart, is it possible for him not to want Jesus Christ's appearance and want the appearance of the Holy Trinity and not to understand that the Holy Trinity is within Jesus Christ? Is it possible for him to ignore what the Christ answered to Philip when this disciple asked Him « Lord, shew us the Father, and it sufficeth us >> (John 14,8)? The Lord answered « Have I been so long time with you, and yet hast thou not known me Phillip? he hath seen me, hath seen my Father, and how sayest thou then, Shew us the Father? Believest thou not that I am in my Father, and the Father in me? the words that I speak unto you I speak not of myself, but the Father that dwelleth in me, he doeth the works. Believe me that I am in the Father and the Father in me » (John 14,9-11).
Well if the believer, the faithful says « Even so, come Lord Jesus » (Rev.22,20),then, since Jesus Christ is in his heart, it (I mean his heart) will become a dwelling place of the Holy Trinity. However, if his heart wants to become a dwelling place of the Holy Trinity without Jesus Christ, then he is mistaken, because the Lord said « I am the door: by me if any man enter in, he shall be saved, and shall go in and out, and find pasture » (John 10,9).
1. When and where, there was slavery, the slave could not do anything by himself in order to be released. But if he was informed that there is someone able to release him, of course he would like to meet Him . What can release man from the sin of the slavery and error, is the Word of Christ that leads to the knowledge of the Truth. All you have to do is to stay faithful to His Word to meet the Truth and this will set you free!
2. When a man is trapped under the ruins, his hope is the rescuers. When someone is shipwrecked at the ocean, his hope is an helicopter. When somebody is condemned to death, his hope is the Grace of God. When someone has been poisoned, his hope is the antidote. When everybody is tired because of the heavy load of the sin, his hope is the Christ who was crossed for the sins of people.
3. A Christian who is interested for the inferior, while his destiny is the superior, reminds us that coal man who, while they were taking him to be a king, he, on the way, each time he saw big trees, he said: they are very good for coals.
4. Is it possible for someone who falls as he is walking, to say, let me stay down after all i can fall again? Of course no. Therefore in the same way, anyone who falls in sins, shouldn't say, i won't go to the spiritual father for my sins, after all i can fall again.
5. The devil has nothing good to offer to man, so he diverts him to worship the beautiful creatures of God, and not God himself.
6. Many people have confessed their sins even in public where they can't even get the due forgiveness. Others don't confess to a spiritual father who has the authority from Christ himself to announce forgiveness. What a pity!! Could they know what injustice they do to themselves, in what a big danger they leave themselves, and what relief they deprive their conscious.
7. The most dangerous lie by which the devil deceives the careless is to make them believe that he doesn't exist. Therefore, they take his evil signs to be their own wisdom.
8. Whoever leans only on his own abilities and not on God is like one who leans with his hands on a rotten walking stick.
9. When one is buried under rubble, one's hope is the rescue team. When one is a castaway in the open sea, one's hope is the helicopter. When one is sentenced to the death penalty, one's hope is mercy. When one is poisoned, one's hope is the antidote. When the entire world is burdened with the heavy load of sin, their hope is Jesus Christ who carries the world's sin.
10. Is the phrase positive action accepted theologically? Not exactly because, if it remains positive action is the best from the negative, but Theology in most cases holds Godly actions .Apostle Paul write concerning,<>(Philippians.2,13). But why therefore some thing which is positive, is not called Godly, after all is coming from God? In other words,<>(James.
Committing suicide is a big sin and its different from all types of murdering . The one who commits suicide has the a ability, if he feels like, some times he regrets. But the murderer , doesn't leave space for him self to regret. The one who has killed or murdered some one, in thinking but in many cases practically, the murdered has the powers or ability to defend him self by actions on words. But the suicide because he him self is the killer of him self, he is not like the murdered one. Now if we come to as to why some one commit suicide, the fact is that there are many reasons and different conditions/circumstances. Some one can commit suicide from disappointment in love, others from financial disorders, others from psychological illness, others not to force him self to reveal the secrets of his country or nation, others may chose death so that without caring of what God will say or do after the death of different way above. For others which are not mentioned, only that one knows.The fact is that, God as the judge , will not judge any one wrongly and whatever he will do will be the truth . The person is not allowed to put an end for his life, because it belongs to God but not him self. Suicide is a result of over thinking / neglecting of some one or not believing in God, Yet the holy spirit doesn't neglect any one . But comfort, request.
It is a known fact that when a conscientious Christian senses that he has committed a sin, he can be rid of it by means of the Spiritual Father's prayer of absolution that will be read to him.
However, if a sin has a certain underlying passion as its cause, it does not mean that along with the sin that was forgiven by the Spiritual Father's prayer, the underlying passion has also been eradicated and gone away, and that the person has thereafter become unimpassioned and perfected.
Thus, in all probability that person will again commit the same sin, because of that underlying passion that he has. Of course it is not our intention to enumerate the ways that passions can be eradicated - when the 1st Antiphon of the 4th Tone says: "From my youth, many sins besiege me; but You, my Saviour, understand this and save me."
Let us only mention here that a passion may not depart immediately, the way a sin does with the Spiritual Father's prayer, but it definitely does weaken, even if slowly, when the struggling Christian resorts to the appropriate spiritual weapons. To give an idea of this gradual weakening of passions, let us present a simplified example: In olden times, a certain well-meaning man had ended up an animal thief. Stealing animals had become his passion. When he became acquainted with a Spiritual Father and confessed his sins and the passion that he had, the elder helped him to cut the habit gradually, because he had discerned that it would not be possible to cut it at once.
So, before leaving, he said: "Could you please do me a favour and not steal any horses from now on?" "Yes" he replied, "that will be easy". And he indeed stopped stealing horses. The next time he went for confession to the Spiritual Father, he again asked him before leaving: "Could you please do me a favour and not steal any goats from now on?"
"Yes" he replied, "although that will be tough, I will do as you say".
And he now stopped stealing goats. After going to confession again and again in the same manner, the Spiritual Father eventually minimized the kinds of animals that the man was accustomed to stealing. So, one day he went to the Spiritual Father, and full of joy said to him:"Father, now all that's left is chickens!"


We have had our brewing system boxed up for almost 6 weeks, we finally couldn't resist to open one of the boxes.
Check out our beautiful kettle. It isn't all that big, but it will make some quality beer. We are also getting ready to hook them up to a custom built control system that will control the heating elements, log temperatures and allow us to turn on and off our pumps.
The image below shows our computerized system that will control our Hot Liquor Tank, Mash Tun and Kettle. From this we will be able to dial in our temperatures that we want to maintain and it will turn on and off our heating elements that are within the tanks.


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Drunk driver charged with fatally striking an e-biker in Canarsie
Posted on June 10, 2019 By Aidan Graham
Mohammed Abdullah was fatally struck by a car while riding an e-bike in Canarsie on June 9.
Photo By Steve Solomonson
A drunk driver fatally struck a man who was riding an e-bike in Canarsie on June 9, according to authorities.
Police arrested 22-year-old Treasure Liggins, who was allegedly speeding along Avenue D at around 10:30 p.m., when she lost control of the vehicle and struck 29-year-old Mohammed Abdullah near the intersection of E. 105th Street. After hitting the e-biker, Liggins proceeded to strike the side of a building, cops said.
Liggins, who later failed a sobriety test, had been traveling with a 4-year-old child in the rear passenger seat, according to investigators.
Emergency first responders arrived on the scene and took Abdullah, who suffered severe trauma to the head and body, to Brookdale Hospital, where doctors pronounced him dead. Liggins and the child were taken to Kings County Hospital where they were treated for minor injuries, according to authorities.
Following the gruesome crash, police charged Liggins with vehicular manslaughter, criminally negligent homicide, acting in a manner injurious to a child and driving while intoxicated, among other charges.
Abdullah's death marks the 11th cyclist killed in the city this year, and the ninth in Brooklyn. The total 2019 fatalities has already surpassed the 10 total cyclist deaths throughout all of 2018, according to city data.
Sunday evening's fatality marks the fourth Brooklynite killed in car-crash related incidents this weekend, after two people struck a traffic pole in Marine Park, and a pedestrian was struck by a car in a Bath Beach crosswalk.
Reach reporter Aidan Graham at agraham@schnepsmedia.com or by calling (718) 260–4577. Follow him at twitter.com/aidangraham95.
Charged: Treasure Liggins was arrested on June 9 and charged with manslaughter, driving while intoxicated, criminally negligent homicide and other charges after she fatally stuck a e-biker in Canarsie.
Aidan Graham
Brooklyn native Aidan Graham is the Deputy Editor of Brooklyn Paper. He is a Mets fan.
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The 2016 Dodge Durango in Dawsonville, GA is sure of becoming an SUV which sets new standards for what most people expect when they buy a vehicle which is both spacious and powerful. The Durango has been a very durable SUV since its original release in 2008. Since then, the vehicle has kept on improving and the 2016 version is no different.
The exterior has experienced a few changes from the 2015 model in order to give the vehicle a bolder look. It also has a more extended wheelbase which will help a 3-column seating plan have more gear space and leg room. Aside from the new power trains that have been added to the lineup, it also has an advanced lodge outline and a more refined exterior styling.
The dashboard will also be updated to match the style and to give a the driver more knowledge at their fingertips. The new Durango will also be furnished externally with the new projector pillar lights in the headlights.


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Борис Константинович Не́мечек (1925—1978) — советский художник кино. Заслуженный художник РСФСР (1965). Лауреат Сталинской премии первой степени (1952).

Биография
Родился 18 мая 1925 года. В 1949 году окончил художественный факультет ВГИКа. В 1949—1957 годах работал на Киевской киностудии художественных фильмов, с 1958 года — на «Мосфильме».

В 1964 —1965 годах читал курс лекция «Работа с художником» на Высших курсах сценаристов и режиссёров

Умер 22 февраля 1978 года. Похоронен в Москве на Ваганьковском кладбище.

Фильмография
  — Тарас Шевченко (совместно с Л. А. Шенгелия)
  — Командир корабля; Лымеривна
  — Костёр бессмертия
  — Над Черемошем (совместно с В. Мигулько); Без вести пропавший
  — Баллада о солдате
  — Чистое небо
  — 49 дней; У твоего порога (оба совместно с А. М. Вайсфельдом)
  — Жили-были старик со старухой
  — Берегись автомобиля
  — Первый курьер (совместно с Н. Наневым)
  — Адам и Хева
  — Легенда тюрьмы Павиак
  — Джентльмены удачи
  — Совсем пропащий
  — Небо со мной
  — Афоня
  — Мимино ''(совместно с Э. К. Немечек)
  — Сдаётся квартира с ребёнком; Любовь моя, печаль моя

Награды и премии
 Сталинская премия первой степени (1952) — за фильм «Тарас Шевченко» (1951)
 заслуженный художник РСФСР (1965)

Примечания

Художники кино СССР
Художники кино России
Члены Союза художников СССР
Выпускники ВГИКа
Социалистический реализм
Персоналии:Мосфильм
Персоналии:Киностудия имени А. Довженко
Похороненные на Ваганьковском кладбище
Преподаватели Высших курсов сценаристов и режиссёров

redpajama_set_name: RedPajamaWikipedia


European Business is not one single entity. It is composed of big companies such as Vodafone, BP, Unilever, Siemens and L'Oreal as well as 23 million more or less unknown small companies.
Small and medium-sized enterprises (SMEs) are often referred to as the backbone of the European economy. They represent around 99 % of all enterprises in the EU and the latest figures released from Eurostat show that 9 out of 10 enterprises in the EU employed fewer than 10 people.
Whatever is making Brussels busy is of interest to these businesses.
For example, integrating the one million refugees who arrived in Europe in 2015 is only possible in co-operation with the continent's companies.
The malfunctioning Schengen area and re-introdution of border controls in Europe make business more complicated.
Also, massive document leaks like LuxLeaks and the Panama Papers surely affect business and may lead to new tax regimes.
This might be good news for small companies. They do not benefit from current cross-border tax-avoidance schemes, but they need to compete with multinationals, some of which get away with paying less than 1 percent tax on their profits.
In the UK, business has played a key role in funding both the Leave and Remain campaigns for the EU referendum.
There is simply a business angle to every topic that Brussels has to deal with.
Tax breaks awarded to multinationals like Apple and Starbucks in Luxembourg allow their businesses to prosper, often at the expense of Europe's 23 million smaller firms.
The European Commission proposes that governments and institutions help refugees, but a better solution would be to boost trade links with countries like Jordan.


The inaugural "Great Lakes" Dirt Challenge will feature a trio of dirt events for USAC's .25 Midget participants at the I-96 Speedway in Lake Odessa, Mich.
Debuting on June 13, the .25 Midgets will return to the track on July 18 and August 8 and the overall point champion will earn the "Great Lakes" Dirt Challenge crown.
I-96 race organizer Mike Mouch believes in the development of young racers and anticipates these events to be a great benefit to his track. "It's exciting to begin this relationship with USAC," he says.. I-96 has hosted eight previous USAC events, including five Sprint races and a Midget race in the 1990s and Ford Focus events in 2006 and 2007. Support programs on all three 2010 dates will include mini-sprints and go-karts.
"Michigan has always been a hotbed of racing and has hosted some memorable USAC events," added USAC Developmental Racing Director James Spink. "I expect the competition on the dirt in these three races to be keen and we look forward to returning to one of Michigan's great short dirt tracks."
The track is located in Lake Odessa, at exit 64 from Interstate 96. The track office can be reached at 616-642-0555. Gate times and pricing will be released at a later time.


At least once a week I have an idea to go somewhere – London, Paris, Gdańsk, Rome.. And every time Kamil is saying no – We can't, we don't have a time, we are going to Poland and Spain this year..
Our plan was very simple – go to London and enjoy. We wanted to see few places, but there was no rush, no pressure. Our biggest worry was the weather. Unfortunately the forecast wasn't really good so we were expecting big rain and strong wind..
Our day started in the bus. We didn't wanted to leave our car in the car park so we took the bus from Navan to the airport. It wasn't the best idea. Trip to the airport was okay, but the coming back home was like a way to hell..
The biggest disappointment of the day happened to us, before we even left our bus – Big Ben under renovation – you couldn't see even a piece of it. I haven't know about it and I have to say it – I was really disappointment.
Our first stop – Buckingham Palace. Beautiful and stunning. But as always – no matter how cold and rainy is – there is always a hundreds of people – where are they coming from?!
Next stop – Admiralty House and the gate of the way to the Buckingham Palace – Admiralty Arch.
We visited a great shop – best for Shrek's fans – Shrek Adventures.
Our next stop – Underbelly Festival. Looks incredible! I really regret that the weather wasn't bit better so we could enjoy a little but more time there.
After that we start heading our main destination – Kings Cross Station, where we wanted to se the 9 3/4 Platform and the Harry Potter shop. Place is great, looks like a movie but .. The queue to the picture – wooow! We would have to wait around 1,5 hours to make a shot so we decided to do a quick shopping and just skip this.
Our next stop – M&M's World and China Town. The M&M's shop was very crowded. All the people were hiding because the weather got bit worse. We spent there few minutes and we went too see the famous China Town.
China Town – I have to say – I love this place. It is great.. I just love the way how it is. Kamil choose one place for a lunch. I wasn't really sure if this is a good idea but he was right. The food was cheap and really delicious. Really good place!
After that we went to see Picadilly Circus and few more places which I saw on Instagram. We end up our walk in small pub on the front of the bus station.
SUMMER MUST HAVE – DRESS SHOULDER OFF!


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Ladies Report: Tranmere Rovers 0-1 Manchester Stingers
Tranmere Rovers' Ladies suffered defeat in the North West Regional League on Sunday afternoon with a 1-0 home loss to Manchester Stingers Women at Ellesmere Port.
Following victories over Wigan Athletic Ladies and Fleetwood Town Wrens, Tranmere returned back to their Ellesmere Port home to welcome the Stingers.
The Ladies side were cheered on by the SWA, and in the first-half, the Stingers took the lead through a well-worked finish following on from a cross which was converted into an empty net after a lapse in concentration at the back for Rovers.
In response, Tranmere saw openings at goal go begging before the half-time interval, testing the Stingers goalkeeper with efforts on target.
TRFC dominated after the break, and with a changed side, they went onto play free-flowing football, going close on several occasions but they couldn't find the equaliser to level things up, and slipped to their first loss of the campaign.
Next up for Rovers Ladies is a trip to Wigan on Sunday 22nd September, 2pm kick-off, as they aim to bounce back after the disappointment.
The team end the month by playing Morecambe Ladies at home on Sunday 29th September, 2pm kick-off.
To find out more about TRFC Ladies' team, CLICK HERE.


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HomeInterested Persons ListPress Release – May 31, 2013 – Summary of Actions Taken at May 30, 2013 Special Meeting
Press Release – May 31, 2013 – Summary of Actions Taken at May 30, 2013 Special Meeting
John St. Croix
For release: May 31, 2013
SUMMARY OF ACTIONS TAKEN AT MAY 30, 2013 SPECIAL MEETING
At its special meeting on May 30, 2013, the San Francisco Ethics Commission took the following actions:
By a vote of 4-0, granted a waiver to Alan Martinez from the one-year post-employment ban under San Francisco Campaign and Governmental Conduct Code section 3/234(a)(2). Mr. Martinez is a licensed architect solo practitioner who formerly served on the Historic Preservation Commission (HPC). The waiver allows him to contact the Planning Department or Planning Commission—but not the HPC—on behalf of his clients regarding their architectural plans.
Considered staff's report on the Budget and Legislative Analyst Report issued on June 5, 2012, which also addressed comments received at Interested Persons meetings held on December 4 and 10, 2012, and February 27, 2013. On several of the items, staff will present follow-up regulatory proposals for the Commission to consider in the coming months.
By a vote of 4-0, approved regulations to require persons who file the Form 700 Statement of Economic Interests with the Ethics Commission to file them in electronic format beginning in January 2014. A regulation adopted by the Commission is effective 60 days after its adoption unless before the expiration of the 60-day period, the Board of Supervisors vetoes the regulation by a two-thirds vote.
The next meeting of the Commission will be a special meeting to be held on Monday, June 24, 2013 in Room 400 City Hall.
The Ethics Commission, established in November 1993, serves the public, City employees and officials and candidates for public office through education and enforcement of ethics laws. Its duties include: filing and auditing of campaign finance disclosure statements, lobbyist and campaign consultant registration and regulation, administration of the public financing program, whistleblower program, conflict of interest reporting, investigations and enforcement, education and training, advice giving and statistical reporting.
S:\Commission\Meeting Summaries\2013\5.30.13 special.doc
Posted in Interested Persons List, Meeting Summaries, News, Press Releases, Public Notices
Recent Interested Persons List
Meeting Summary – Summary of Matters Discussed and Actions Taken at Ethics Commission's January 20, 2023 Special Meeting Posted: Jan 23, 2023
Statement of SF Ethics Commission Chair Yvonne Lee on Guilty Plea of Former City Official Over Corruption Charges Posted: Jan 18, 2023
Agenda – January 20, 2023 Posted: Jan 17, 2023
Meeting Summary – Summary of Matters Discussed and Actions Taken at Ethics Commission's January 13, 2023 Regular Meeting Posted: Jan 17, 2023
Agenda – January 13, 2023 Posted: Jan 9, 2023


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Back Issue Bloodbath Episode 192: Did Franchise Expansion Ruin The Avengers Comic?
by Andrew Young | Jul 3, 2019 | Back Issue Bloodbath
It's the final episode of Guest Host Month as Andrew and his brother (and FUN FAIR co-host), Nathan Young, talk about a comic franchise near and dear to their hearts: The Avengers! It's no secret that over the past 15 years The Avengers went from just another super team to mainstream icons! The movies had a lot to do with that. But the comics went from a single title to a eclectic line of books in various shapes and sizes. That begs the question, "Did this Franchise expansion ruin The Avengers?" Andrew and Nathan attempt to find the answer.
Starting at the birth of New Avengers in 2005, Andrew and Nathan follow the timeline to the introduction of additional Avengers titles, charting from two titles, to four titles, to seven titles. They look at the commercial success and the creative merit of each book and share their findings.
If you're a fan of Earth's Mightiest Heroes, you might be interested in this short history lesson on the evolution of this super team and it's impact on the comics market. Even if you're not, it's an interesting look on the effects of overexposure on the comic racks. Take a listen. You might learn something on an ALL NEW Back Issue Bloodbath.
Have an idea for a certain topic we should cover? Have an indie comic book you'd like us to review? Send us an email at geekhardshow@gmail.com with "Back Issue Bloodbath" in the subject line. We'd love to hear from you. And be sure to join our Facebook page for exclusive content. Support us on Patreon.


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Q: Facebook post to friends is any way to post request to user friends without dialog , maybe trow api?
function post_request($fbApp, $fbID, $post)
 {
  static $ins;
 if (empty ($ins[$fbApp]))
  {
     Facebook::setConfig ($fbApp);
     $ins[$fbApp] = new Facebook();
  }
 try
  {
  $res = $ins[$fbApp] -> api ('/' . $fbID . '/apprequests', 'POST', $post);
  return true;
  }
 catch (FacebookApiException $e)
  {
  return false;
  }
 }

A: No, not anymore. Could be done long time ago, but since 2010 I think, no.


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Portrety Montefeltrów, też Portret Federica da Montefeltro i jego żony, Battisty Sforzy () – dyptyk portretowy namalowany przez renesansowego artystę Piera della Francesca w latach 1465–1470. Obecnie znajduje się w Galerii Uffizi we Florencji.

Opis obrazu
Twarz mężczyzny jest żywa i pełna energii, podczas gdy rysy twarzy kobiety są uogólnione (najprawdopodobniej był to portret pośmiertny). Artysta skupia uwagę widza na ubiorze postaci i klejnotach. Piero della Francesca poprzez ujęcia z profilu nawiązuje do tradycyjnego włoskiego portretu.

Obrazy cechuje realizm oraz pejzaże w tle:
 u kobiety: ziemia – symbol przemijania,
 u mężczyzny: woda – odwieczny symbol życia.

Na odwrocie obrazów namalowane są alegoryczne triumfy obojga małżonków.

Bibliografia
 Tatjana Pauli, Klasycy sztuki – tom 16. Piero della Francesca.

Linki zewnętrzne
   na stronie Virtual Uffizi.

Obrazy w Galerii Uffizi
S
Obrazy Piera della Francesca
Dyptyki (malarstwo)


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Join the legendary Manfreds and Georgie Fame for an evening of Rhythm and Blues nostalgia, and some of the greatest hits ever written.
The Manfreds with an all-star line-up of original members Paul Jones, Mike D'Abo, Tom McGuinness and Mike Hugg with Rob Townsend, Marcus Cliffe and Simon Currie will be recreating many of their greatest hits both as part of Manfred Mann and as successful solo artists.
Joining the Manfreds is bone fide legend Georgie Fame. With more than 20 albums and a career full of collaboration with music's most famous names, Georgie has rightly earned iconic status in the British music scene.
An all-star line-up with the hits to match!
5-4-3-2-1 • Do Wah Diddy • The Mighty Quinn • Pretty Flamingo • Fox On The Run
Handbags & Gladrags • Yeh Yeh • Get Away • The Ballad of Bonnie and Clyde and many more!
PR Queries: Max – Deacon Communications
(E) info@deaconcommunications.com
(T) 020 3176 6606


Did you get enough sleep last night? If not, this video is for you. It turns out sleep does a lot more than just help us feel rested the next day.
College students are known for staying up to cram for midterms and finals. (Maybe you still cram—only now it's for important meetings and presentations.) In this TEDEd video, neurologist Shai Marcu explains that if you actually want to remember what you've learned, you have to sleep on it.


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Published: Thursday, 30 December 2021 13:57
There's been a 12 per cent increase in the number of incidents dealt with by the Coast Guard this year.
It responded to just under 3 thousand - with April and July the busiest months.
The service says it provided help in 474 cases where a loss of life or long-term injury was avoided.
A total of 68 drownings were recorded this year - a decrease of 7 on last year.


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SC Flood Information
Dam Reports
To further inform the public, the agency has made available dam inspection reports for confirmed failed dams during the October 2015 flood event, final inspection reports for all Class 1, 2 and 3 dams statewide, and additional reports of interest to community stakeholders.
Dam Owner Information Event
Historic Updates and Information
Hurricane Matthew Breached Dams
Hurricane Matthew Damaged Dams
In response to October 2015's historic rainfall and flooding, S.C. Department of Health and Environmental Control (DHEC) staff has worked diligently throughout the past year to assess the impact on dams across the state. During and immediately after the 2015 flood, 150 DHEC staff worked around the clock for more than 6,500 work-hours on emergency response, data tracking and conducting emergency inspections of dams.
Our team partnered with the U.S. Army Corps of Engineers, Homeland Security, South Carolina Electric & Gas (SCE&G) and HDR Engineering as part of our response to the 1,000-year rainfall and statewide assessment of all high- and significant-hazard dams and some low-hazard dams. Following the historic flood event, DHEC:
Assessed all 652 dams high- and significant-hazard dams statewide and identified some low-hazard dams.
Confirmed 51 regulated dams breached / failed during the flood event.
Issued Emergency Orders covering 75 dams.
Sent a Notice of Violation to owners of 29 dams who did not provide documentation of their required action items by the deadline within a month of issuance of the Emergency Orders.
Identified 192 additional dams as being in need of inspection and potentially requiring non-emergent maintenance or repairs.
Partnered with HDR Engineering to conduct a complete review of the agency's Dam Safety Program.
Contracted with HDR Engineering to conduct an engineering review and assessment of the Gills Creek Watershed in Richland County and Twelve Mile Creek Watershed in Lexington County.
Ongoing Recovery Efforts
Currently, our staff continues to assist dam owners to ensure that dams are safe. We are working with many dam owners and their engineers on a plan of action for repairing or removing affected dams. As part of our state's ongoing recovery effort, DHEC has:
Received 72 permit applications from dam owners to repair or rebuild their structures that were damaged during October's historic flooding event.
Issued 36 permits to repair dams that were damaged due to the October 2015 flood and one permit to remove a dam. This action includes permits issued pursuant to emergency orders or other DHEC directives, such as the inspection and maintenance letters issued in November 2015.
Hosted a forum for dam owners on March 12, 2016 , to help connect dam owners to information and people who can help them move toward recovery.
Continued to work with dam owners to provide technical assistance so that they can make final decisions on the future of their dams and implement the repairs.
Continued to work collaboratively with the S.C. Department of Transportation (SCDOT) to share information and provide technical assistance related to roads impacted by both regulated and unregulated dams.
In addition, the agency continues to evaluate the responses to the emergency orders issued after the flood and is conducting follow-up site visits to assess if appropriate actions are being taken. Our overall goal is to ensure dams are put in a safe condition to protect life and property. In instances where the owners have not complied with department requests for action, the dams have been referred for inspection and possible enforcement pursuant to provisions in the Dams & Reservoir Safety Act and Regulations.
State regulation allows owners to make the decision whether to repair or remove damaged dams, regardless of the percentage of the structure that may be damaged. If an owner decides to repair or remove a dam, he/she must follow state requirements including filing a permit application for DHEC to review and approve. We are currently working with dam owners to provide technical assistance so that they can make final decisions on the future of their dams and implement the repairs.
The Dam Safety Program has issued 37 permits since October 2015. This action includes permits issued pursuant to Emergency Orders or other DHEC directives, such as the maintenance and inspection letters issued in November.
Dam Reclassification
DHEC staff is continuing to evaluate dams for possible reclassification. The evaluation process for regulating a dam includes researching property records to determine the owner, conducting field surveys and taking other measurements to assess if the dam meets the height and/or volume thresholds for regulation, and reviewing the regulatory exemptions and inundation mapping to assess the hazard potential of the dam. Since the October 2015 flood, the following dams have been reclassified, added to the inventory or determined to be exempt from the regulation as of Sept. 23, 2016:
McGee Pond Dam (D 3103) in Anderson County was reclassified from low to high hazard on Aug. 30, 2016.
Glenn Pond Dam #2 (D 3108) in Anderson County was reclassified from low to high hazard on Sept. 2, 2016.
Von Hollen Pond Dam (D 3138) in Anderson County was reclassified from low to high hazard on Sept. 2, 2016.
G. Stevens Pond Dam (D 3147) in Anderson County was reclassified from low to high hazard on Sept. 6, 2016.
Seaton Acres Pond Dam (D 3153) in Anderson County was reclassified from low hazard to high hazard on Sept. 6, 2016.
SCNONAME 09031 (D 2645) in Calhoun County was exempted from the inventory on Sept. 13, 2016.
Elliot Millpond Dam (D 3495) in Clarendon County was exempted from the inventory on June 15, 2016.
SCNONAME 32105 (D 1042) in Lexington County was exempted from the inventory on June 7, 2016.
North Springs Lake Dam (D 0550) in Richland County was reclassified from low hazard to high hazard on June 14, 2016.
Kennedy Dam (D 4901) in Richland County was added to the inventory and assigned a significant hazard classification on Feb. 10, 2016.
Pine Tree Dam (D 4905) in Richland County was added to the inventory and assigned a high hazard classification on Aug. 11, 2016.
Cleveland Park Dam (D 3352) in Spartanburg County was reclassified from significant to high hazard on March 24, 2016.
Black Crest Pond Dam (D 2063) in Sumter County was exempted from the inventory on April 28, 2016.
As a result of the 2015 historic flood, there were road closures on 23 regulated dams. As of as of Sept. 23, 2016, roads were closed due to 11 failed or damaged regulated dams.
Cypress Lake Dam (D 3484) in Clarendon County
O. E. Rose Dam (D 3487) in Clarendon County
Crout Pond Dam (D 0945) in Lexington County
Lake Elizabeth Dam (D 0024) in Richland County
Spring Lake Dam (D 0025) in Richland County
Cary's Lake Dam (D 0026) in Richland County
Rocky Ford Lake Dam (D 0028) in Richland County
North Lake Dam (D 0029) in Richland County
Arcadia Woods Lake Dam (D 0557) in Richland County
Lake Trotwood Dam (D 0582) in Richland County
Weston Pond Dam (D 0593) in Richland County
DHEC is continuing to work collaboratively with the SCDOT to share information and provide technical assistance related to roads impacted by both regulated and unregulated dams. We are working with dam owners to provide technical assistance so that they can make final decisions on the future of their dams and implement the repairs.
Our Program Today
We are working to take what we've learned from the 1,000-year storm event to make the program stronger. During the past year, DHEC has taken the following measures to strengthen response preparation and create a more robust Dam Safety Program:
As of September 2016 additional resources from the S.C. General Assembly will expand the Dam Safety Program to approximately 14 full-time staff members -almost doubling the program size.
Collaborated with Emergency Communications Network to initiate their CodeRED system to allow automated notification to dam owners via voice call, text messages and email in preparation for the potential significant rainfall. This system was used during response to Hurricane Hermine in September 2016.
Established a coalition of dam owners, engineers, and other stakeholders with interest in dam safety to provide a forum to discuss the impact of the Dam Safety Program on the regulated community.
Held "Dams After the Flood: Regulations, Responsibilities and Recovery" an event designed to connect dam owners to information and people who can help them move toward recovery.
Presented to numerous groups, including SCEMD, FEMA, South Carolina Watershed Districts, American Society of Civil Engineers, OSHA's Mine Safety and Health Administration, and others on the impact of October's storm on dams in the state. Most recently, DHEC presented on the agency's response to the flood and lessons learned at "Dam Safety 2016" in Philadelphia. This annual conference, hosted by the Association of State Dam Safety Officials, is one of the leading conferences in the United States on dam and levee safety engineering and incident management.
Partnered with CDM Smith to provide long-term engineering support to the Dam Safety Program, including the development of owner/operator training and the review of engineering plans.
The process of rebuilding and repairing affected dams will be ongoing as our experts work with each dam's unique situation. Throughout the next months, we will be hiring and training new engineers, issuing repair permits and conducting inspections, reclassifying regulated dams, fine-tuning standard operating procedures and refining GIS tools to monitor rainfall and its impact on dams.
Records on Breached Dams Inspection Reports Emergency Orders Dam Repair Application Status Report Non-Emergent Inspection Letters Notice of Violations HDR - Twelve Mile Creek Watershed: Assessment of Regulated Dams (pdf) HDR - Gills Creek Watershed: Assessment of Regulated Dams Dam Owner Information Event Historic Updates and Information Hurricane Matthew Breached Dams Hurricane Matthew Damaged Dams 2017 Dam Inspection Schedule
When a Tropical Storm or Hurricane is Approaching
DHEC Weather Event Notices and Cancellations
2018 Flood: More Language Resources
Get the latest DHEC Dorian Updates!


The interaction of the five elements of earth, water, fire, air and ether, however simple it may appear, often inspires a feeling of true mystery in me. The more I study the elements, the more I discover how multi-layered Samkhya philosophy actually is. In essence all the elements are present, to varying degrees, in every physical appearance, including our own bodies and minds that we use to interpret our experiences.
According to Vedic seers there are three basic forces in existence. Life is a play of these forces, continually changing and interacting.
The first force is #prana (Energy), associated with the primal breath or life-force, divine will, pure consciousness and the element air. The second force is #jyoti (Light), associated with illumination or radiance, transformation, intelligence and the element fire. The third force is #prema (Love), associated with vigor or vital essence, cohesion, sustainability and the element water.
In the manifestation process of these forces into our physical bodies and minds the elements are often disrupted from their harmonious flow.
During my recent travels in India, I developed a real fascination with the element of Fire, partly because I'm Pitta dosha, but also since I found myself devoted to Arunachala, a holy Shiva mountain in Tiruvannamalai and spent much time in the Annamalaiyar temple, one of the most significant Shiva sights, associated with the element Fire.
Upon returning home I became very aware of how modern life affects my nervous system and how important it is to balance these core elements inside me, especially the intense fluctuations from too much Fire to too much Water, from high energy irritation, frustration and anger to low energy lethargy, dullness and depression. I believe it's a common modern phenomenon that many of us experience through the increase of technology and our fast-paced lifestyles.
Exploring the three cosmic forces guide me to find more balance. But it's not a quick-fix journey, Yoga is a life-long commitment that requires raw humility, true honesty and trust in the unfolding mystery of life in this human form.