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Cooperative Agreement To Support Innovation in Vaccine Clinical Trial Design and Collaboration in Pharmacovigilance To Advance Global Access to Safe and Effective Vaccines
A Notice by the Food and Drug Administration on 05/16/2012
Important dates are as follows:
Relevant information about this document from Regulations.gov provides additional context. This information is not part of the official Federal Register document.
FDA-2012-N-0009
I. Funding Opportunity Description
1. Innovative Vaccine Clinical Trial Design
2. Vaccine Pharmacovigilance
B. Research Objectives
2. Improving Allocation of Safety Data Collection Throughout the Vaccine Development Life Cycle
3. Enhancing Postmarketing Surveillance of Vaccine Safety
4. Dissemination of Successful Enhancements to the Vaccine Clinical Trial and Pharmacovigilance Enterprise Through Seminars or Other Training Programs
C. Eligibility Information
II. Award Information/Funds Available
A. Award Amount
B. Length of Support
III. Paper Application, Registration, and Submission Information
The Food and Drug Administration (FDA) announces its intention to accept and consider a single source application for an award of a cooperative agreement to the World Health Organization (WHO) in support of collaborative efforts to advance innovative approaches to vaccine clinical trial design and to enhance the utilization of a range of pharmacovigilance tools as a means to further vaccine safety and potentially facilitate more rapid introduction of new vaccines. The goal of FDA's Center for Biologics Evaluation and Research (CBER) is to enhance technical collaboration and cooperation between FDA, WHO, and its Member States to facilitate strengthening regulatory capacity globally.
1. The application due date is June 15, 2012.
2. The anticipated start date is September 15, 2012.
3. The expiration date is June 16, 2012.
Submit the paper application to: Vieda Hubbard, Grants Management (HFA-500), 5630 Fishers Lane, Rockville, MD 20857, and a copy to Leslie Haynes, Center for Biologics Evaluation and Research, Office of the Director (HFM-30), 1401 Rockville Pike, Rockville, MD 20852-1448. For more information, see section III of the SUPPLEMENTARY INFORMATION section of this notice.
Gopa Raychaudhuri, Office of the Director (HFM-1), Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, 301-827-6352, email: gopa.raychaudhuri@fda.hhs.gov. or
Leslie Haynes, Office of the Director (HFM-30), Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, 301-827-3114, email: leslie.haynes@fda.hhs.gov. or
Vieda Hubbard, Office of Acquisitions and Grants Services (HFA 500), Food and Drug Administration, 5630 Fishers Lane, Rockville, MD 20857, 301-827-7177, email: vieda.hubbard@fda.hhs.gov.
For more information on this funding opportunity announcement (FOA) and to obtain detailed requirements, please refer to the full FOA located at http://www.fda.gov/BiologicsBloodVaccines/ScienceResearch/ucm297861.htm.
RFA-FD-12-022
CBER has been a leader and active participant in the global community to improve human health in the world's populations over many years. A significant area of engagement for CBER is its support of innovative science to advance vaccine development and to improve access of the global population to safe and effective vaccines. The U.S. Department of Health and Human Services (HHS) has invested significantly in developing sustainable global vaccines production capacity. Adequate regulatory oversight throughout the vaccine development life cycle is essential in assuring the safety, purity, and potency of vaccines and other biologicals.
WHO is the directing and coordinating authority for health within the United Nations system. It is responsible for providing leadership on global health matters, shaping the health research agenda, setting norms and standards, articulating evidence-based policy options, providing technical support to countries, and monitoring and assessing health trends. It is the only organization with the mandate, technical expertise, and broad reach to meet the Summary Objectives.
WHO has played a key role for over 50 years in establishing international guidelines and standards for development and use of vaccines and other biologicals. The assessment, licensure, regulatory control, and surveillance of vaccines and biological medicinal products are major challenges for national regulatory authorities confronted by a steadily increasing number of novel products, complex quality concerns, new regulatory issues arising from rapid technical and technological advances, and emerging infectious diseases (e.g., pandemic influenza). With the globalization of markets, the volume of vaccines and biological medicinal products crossing national borders continues to rise, making it even more critical that regulatory knowledge and experience be shared as appropriate to do so, and that global monitoring to ensure product safety be harmonized to the greatest extent possible.
WHO played a leading role in coordinating pharmacovigilance activities and exchange of information among regulators and public health authorities during the H1N1 pandemic. WHO has further demonstrated its leadership in the cause of vaccine safety through its Global Vaccine Safety Blueprint effort, a WHO initiative that focuses on monitoring vaccine safety once a product has been licensed for use. The Blueprint focuses on the need to monitor vaccinated populations for the occurrence of adverse events following immunization (AEFI), and to address vaccine safety concerns in a timely manner when they arise.
CBER has been a leader and active participant in the global community to improve human health in the world's populations over many years. Its international engagements have been informed by the knowledge that protection of global public health against infectious disease threats translates into protection of public health in the United States. In its capacity as a Pan American Health Organization/WHO Collaborating Center for Biological Standardization, CBER has supported many of WHO's efforts to advance vaccine safety, including serving on the Consultative Committee of the Global Vaccine Safety Blueprint project, serving on the WHO Global Advisory Committee on Vaccine Safety, and collaborating with the Uppsala Monitoring Center (UMC), a WHO Collaborating Center that is responsible for maintaining the global Adverse Drug Reaction database, Vigibase.
CBER seeks to support efforts to advance innovative approaches to vaccine clinical trial designs and to enhance the utilization of a range of pharmacovigilance tools as a means to further vaccine safety and potentially facilitate more rapid introduction of new vaccines. The two primary focus areas are:
Clinical trials are performed to evaluate the safety and efficacy of vaccines. Improving the efficiency of vaccine clinical trials in the development process could lead to more rapid availability of new vaccines. In the case of early phase clinical trials, new approaches can more rapidly determine whether novel vaccine candidates are likely to be safe and efficacious, and better approaches to optimizing allocation of study participants between late phase clinical trials and postmarketing safety studies could lead to more rapid access to lifesaving vaccines, while still obtaining the data necessary to ensure vaccine safety.
An important regulatory tool to assure vaccines are safe and effective is a robust pharmacovigilance system. The decision to license a product is based on information available at the time of approval, and the conditions for use are specified in the product label. However, the knowledge related to the safety profile of the product can change over time through expanded use in greater numbers of people and in diverse populations. Rare adverse events often are not identified in clinical trials since the numbers of subjects enrolled in the trials are not large enough to detect low frequency signals. Thus, it is essential to continue monitoring vaccine safety throughout the product life cycle and to obtain and analyze any additional safety information in "real time."
This project represents a collaborative effort between CBER and WHO (and complements and builds upon other existing commitments of FDA and HHS with WHO) to support scientific collaboration and enhance regulatory capabilities of National Regulatory Authorities to advance global access to safe and effective vaccines and other biologicals that meet international standards. This project will lead to improved technical cooperation between FDA, WHO, and its Member States.
In recent years there has been interest in finding innovative study designs to speed development of promising new vaccines, particularly in disease areas where an urgent and unmet need exists. Diseases such as malaria, tuberculosis, and human immunodeficiency virus are especially challenging due to the widespread public health impact of these diseases, as well as the fact that traditional vaccine development mechanisms do not appear applicable because of the nature of the disease pathogens and/or the natural history of the disease. Bringing these candidate vaccines forward into larger late Phase 2 or Phase 3 clinical trials has had minimal success to date. The goals, thus, in seeking innovative trial designs are to: (1) Minimize the number of ineffective candidate vaccines that proceed into late Phase 2/Phase 3 trials, (2) enhance ability to identify promising candidate vaccines early to move forward into late Phase trials, (3) obtain answers to other scientific questions of interest (e.g. establishing correlates of protection) more quickly, and (4) promote more efficient use of resources. Of special interest are various types of adaptive trial designs and other innovations in clinical study designs.
Achieving optimal allocation of safety data collection at each phase of the product development life cycle requires a better understanding of the interplay among disease morbidity and mortality, vaccine effectiveness and safety, quality of study designs, individual risk perception, and vaccination choice. One approach to obtain this understanding is through mathematical simulation of the vaccine development life cycle. Additional research in both the structure of the mathematical models and how to decide what constitutes the acceptable vaccine risk is needed to advance this work. Further translation of such theoretical work into practical study designs and pharmacovigilance activities through demonstration projects would also be desirable.
Four types of activities are of interest:
a. Improvement of the evaluation of centralized spontaneous reporting systems data. Efficient and rigorous analysis of spontaneous reports of adverse events following immunization, maintained at the UMC, through improvements in application of case definitions, data mining algorithms, vaccine dictionaries, and development of case-based reasoning strategies (such as text mining and natural language processing and statistical and mathematical algorithms), and other approaches would be considered.
b. Improvements in the interoperability of global pharmacovigilance systems. Examples include the development and implementation of a database that would allow tracking global distribution and use of any vaccine (including vaccine constituents and dose information) and enable linkages to existing global pharmacovigilance systems where those vaccines are in use, as a basis for rapid response to vaccine safety concerns arising in any country where a vaccine is distributed. For countries that have electronic population-based health care data systems, this could include improvements in data architecture (e.g. use of electronic medical records), methods for near real-time surveillance, and conducting definitive studies with rigorous case definitions in an efficient manner for vaccine safety surveillance following globally accepted standards to help create a global vaccine safety data link.
c. Improving approaches to rigorous vaccine safety studies in low and middle income countries (LMICs). The basic requirements for a collaborative approach of this kind in LMICs would be: That the methodology is simple, so it could be easily implemented and standardized for all sites; is timely; only uses resources already available in the local public health system; and avoids the need for population denominators. An example of successful use of this approach is the 2009 H1N1 influenza vaccine safety study using the self-controlled case series methodology. Improving this approach, because of its flexibility and applicability to countries where population denominator information may not be available, is one direction that could be taken.
d. Evaluating social media and mobile communication devices for vaccine safety in LMICs. The use of social media for public health information has received attention recently because of the success of "Google flu trends" (http://www.google.org/flutrends/) and "HealthMaps" (http://healthmap.org/en/) in identifying infectious disease outbreaks, at least as fast as traditional methods but at lower cost. Evaluation of methods for efficient approaches to aggregating the highest quality information from the Internet and social media for earlier warning of emerging safety concerns or identifying geographically localized clusters for regulators and public health authorities, might be beneficial. Mobile communication devices have been successfully used for drug safety surveillance in Africa. Evaluation of mobile devices for inexpensive alerting of central monitoring point for AEFI might be warranted. The collation, investigation, and analysis of such reports remains a challenge but might be resolved by the development and deployment of artificial intelligence systems to conduct data mining and semiautomated case-series evaluations that would provide cogent summaries for human review.
WHO is the directing and coordinating authority for health within the United Nations system. It is responsible for providing leadership on global health matters, shaping the health research agenda, setting norms and standards, articulating evidence-based policy options, providing technical support to countries, and monitoring and assessing health trends. It is the only organization with the mandate, technical expertise, and broad reach through its Member States to meet the project goals.
CBER anticipates providing in FY2012 up to $2 million (total costs include direct and indirect costs) for one award subject to availability of funds in support of this project. The possibility of 4 additional years of support up to $10 million of funding is contingent upon successful performance and the availability of funds.
The support will be 1 year with the possibility of an additional 4 years of noncompetitive support. Continuation beyond the first year will be based on satisfactory performance during the preceding year, receipt of a noncompeting continuation application, and available Federal Fiscal Year appropriations.
To submit a paper application in response to this FOA, the applicant should first review the full announcement located at http://www.fda.gov/BiologicsBloodVaccines/ScienceResearch/ucm297861.htm. (FDA has verified the Web site addresses throughout this document, but FDA is not responsible for any subsequent changes to the Web sites after this document publishes in the Federal Register.) Persons interested in applying for a grant may obtain an application at http://grants.nih.gov/grants/funding/phs398/phs398.html. For all paper application submissions, the following steps are required:
Step 1: Obtain a Dun and Bradstreet (DUNS) Number.
Step 2: Register With Central Contractor Registration.
Steps 1 and 2, in detail, can be found at http://www07.grants.gov/applicants/organization_registration.jsp. After you have followed these steps, submit the paper application to: Vieda Hubbard, Grants Management (HFA-500), 5630 Fishers Lane, Rockville, MD 20857, and a copy to Leslie Haynes, Center for Biologics Evaluation and Research, Office of the Director (HFM-30), 1401 Rockville Pike, Rockville, MD 20852-1448.
Dated: May 10, 2012.
Leslie Kux,
Assistant Commissioner for Policy.


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Q: Run Django Project on other system I have developed a student website using django which includes a database(MySQL), so now I want to run this django project in another system, so how can I run this django project in another system including the database(that is MySQL)

A: You can make a backup of the database and copy it to the other system. Then you can create a  requirements.txt file to get the dependencies, or you just try to run the project and look which packages are missing. The last thing you have to do is that you may change some paths to different files, you added in your Project. This might also help you.
Hope I could help you!

redpajama_set_name: RedPajamaStackExchange


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BETHESDA, Md.—Extending noninvasive prenatal screening to all 24 human chromosomes can detect genetic disorders that may explain miscarriage and abnormalities during pregnancy, according to a study by researchers at the National Institutes of Health and other institutions. Because of the way data have been analyzed, typical genomic tests performed during pregnancy have targeted extra copies of chromosomes 21, 18 and 13, but rarely evaluated all 24 chromosomes. The study findings, which appear in the August 30 issue of Science Translational Medicine, may ultimately improve the accuracy of these tests, including by explaining why some give false-positive results.
"Extending our analysis to all chromosomes allowed us to identify risk for serious complications and potentially reduce false-positive results for Down syndrome and other genetic conditions," said Dr. Diana W. Bianchi, senior author of the study and chief of the Prenatal Genomics and Therapy Section at NIH's National Human Genome Research Institute (NHGRI).
The investigators analyzed DNA sequence data from nearly 90,000 samples of maternal plasma, the liquid portion of blood after all cells have been removed. Of these samples, 72,972 came from a U.S. cohort and 16,885 came from an Australian cohort.


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Men At Large discovered by the late great Gerald Levert are the last of a dying breed! In 1992 Men At Large shocked the world with its self-titled debut on the Atlantic Records label. Their first single "Use Me" became an instant radio hit inspiring B.E.T, to use it for a station jingle.They would go on to release 4 more singles from the cd. "You Me", "Umm Umm Good", "Would You Like to Dance", and the RnB Classic "So Alone" which made Billboard Hot 100 list and was radio's #1 song of the year in 1993. Traveling the world with its other 90's cohorts (Rude Boys, Shai, Silk, H-Town, Levert, S.W.V. etc) they would leave each city with the reputation of being the "Show Stoppers!"
It didn't stop there in 1994 they released "One Size Fits All" again garnering critical acclaim. Releasing 2 singles "Let's Talk About It" and "Holiday" top 10 and 20 respectively they continued to shock the world town by town. Being bred by Eddie and Gerald Levert gave these 2 an obvious advantage. As time moved on the duo would sever ties with the Levert camp only to find the next chapters not as plentiful as the beginning. Still riding off the success of its first 2 records the boys would continue to ride the rails of success as the people just couldn't get enough of the boys. In 1999 and 2007 they released "Love Struggle and Progress" and "Back on Top" doing mediocre numbers but plentiful on an independent level winning best group awards and independent video of the year nominations, only to lose to the great Kenny Rogers. The group still tours extensively around the country with their 90s music peers leaving the crowd amazed and wanting more. Their powerful vocals and zany stage antics keep the fans applauding. Bred from the Levert pedigree what else would you expect! They're also part of an incredible new project that features Silk, Troop, and J. Holiday! "Growth of a Man Inspired by Her" is an album with songs all dedicated to the ladies. The proceeds from the project all go to the G.E.M.S. and A.E.R. foundations whose sole objective is to create greater educational opportunities for inner-city youths! The first single "Date Night" is an ode to traditional RnB and the way relationships used to be created by dating and getting to know one another. Men at Large is leading the pack with this one. Their smooth vocals and infectious melodies will make the world sing and help them remember why Men at Large are truly the "Heavyweight Champs of RnB"!
1992 Men At Large
Platinum/Atlantic
1994 One Size Fits All
Gold/Atlantic
1997 Love Struggle & Progress
Rival (Indi)
2007 Back On Top
Couzan (Indi)
MEN AT LARGE

redpajama_set_name: RedPajamaCommonCrawl


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OALibJ Vol.1 No.7 , October 2014
An Incentive Scheme to Increase Female Access to and Completion of Basic Education in the Democratic Republic of the Congo
Noel A. Ihebuzor
Development and Educational Consultant, Abuja, Nigeria.
Abstract: Policy reforms in education have considerable potential to correct social inequities and assist in the building of more inclusive societies either through improved efficiencies and/or equity in education service provision. Primary education is a public service whose consumption has huge positive externalities—social and economic benefits. In many developing countries, girls are usually excluded from the consumption of this service for a variety of reasons—some of which are social, cultural or economic. The article describes and justifies a reform initiative conceived to increase female access to primary education in the Democratic Republic of Congo (DRC) and sketches an incentive scheme, whose purpose is to improve teacher commitment and improve learning outcomes, for its implementation. The reform measure being proposed, specific egalitarianism (a progenitor of modern-day social transfer schemes) is argued to be robust enough to ensure that girls who are usually the most excluded ones from primary education in the Democratic Republic of Congo (DRC) are enable to access this service as a way of addressing gender equity issues. This type of social transfer (social benefit) strategy when coupled with an incentive scheme that rewards teachers for productivity would yield the socially desirable/beneficial outcome of more girls' enrolling and completing primary education.
Keywords: Social Benefits, Girls Education, Specific Egalitarianism, Conditional Cash Transfers, Incentive Schemes, Performance Measures
Cite this paper: Ihebuzor, N. (2014) An Incentive Scheme to Increase Female Access to and Completion of Basic Education in the Democratic Republic of the Congo. Open Access Library Journal, 1, 1-7. doi: 10.4236/oalib.1101023.
[1] UNICEF/RDC (2001) Enquete nationale sur la situation des enfants et des femmes. MICS2, Multiple Indicator Cluster Study, UNICEF/USAID, Kinshasa.
[2] UNICEF (2007) School Fee Practice and Policy in the DRC—Frais de fonctionnementoufonds de famille. UNIICEF, DRC, Kinshasa.
[3] Stiglitz, J.E. (2000) Economics of the Public Sector. Norton, New York.
[4] Besley, T. and Ghatak, M. (2003) Incentives, Choice, and Accountability in the Provision of Public Services. Oxford Review of Economic Policy, 19, 235-249.
http://dx.doi.org/10.1093/oxrep/19.2.235
[5] Junankar, P.N. and Liu, J. (2003) Estimating the Social Rate of Return to Education for Indigenous Australians. Education Economics, 11, 169-192.
[6] Boyle, S., Brock, A., Mace, J. and Sibbons, M. (2002) Reaching the Poor—The Costs of Sending Children to School. DFID, London.
[7] Tobin, J. (1970) On Limiting the Domain of Inequality. Journal of Law and Economics, 13, 263-277.
http://dx.doi.org/10.1086/466693
[8] DFID (2011) Cash Transfers Literature Review. DFID/UKaid, London, UK.
[9] World Bank (2004) Cost, Financing and School Effectiveness in Malawi: A future of Limited Choice and Endless Opportunities. Working Paper 78, Washington DC.
[10] World Bank (2005) Mozambique Poverty and Social Impact Analysis: Primary School Enrolment and Retention—The Impact of School Fees. Report No. 29423-MZ, The World Bank, Washington, DC.
[11] Banerjee, A. and Duflo, E. (2006) Addressing Absence. Journal of Economic Perspectives, 20, 117-132.
[12] Chaudhury, N., Hammer, J., Kremer, M., Muralidharan, K. and Roger, F.H. (2006) Missing in Action, Teacher and Health Worker Absence in Developing Countries. Journal of Economic Perspectives, 20, 91-116.
[13] Courty, P. and Marschke, G. (2003) Dynamics of Performance-Measurement Systems. Oxford Review of Economic Policy, 19, 268-284.
[14] Burgess, S. and Ratto, M. (2003) The Role of Incentives in the Public Sector: Issue and Evidence. Oxford Review of Economic Policy, 19, 285-300.
[15] Prentice, G., Burgess, S. and Propper, C. (2007) Performance Pay in the Public Sector: A Review of the Issues and Evidence.
[16] Bevan, G. and Hood, C. (2006) What's Measured Is What Matters: Targets and Gaming in the English Public Health Care, System. Public Administration, 84, 517-538.
[17] Duflo, E., Hanna, R. and Ryan, S. (2008) Monitoring Works: Getting Teachers to Come to School. Centre for Economic Policy Research, Massachusetts.
[18] Hood, C. (2007) Public Service Management by Numbers: Why Does It Vary? Where Has It Come from? What Are the Gaps and the Puzzles? Public Money and Management, 27, 95-102.
[19] Propper, C. and Wilson, D. (2003) The Use and Usefulness of Performance Measures in the Public Sector. Oxford Review of Economic Policy, 19, 250-267.
[20] Smith, P. (1995) On the Unintended Consequences of Publishing Performance Data in the Public Sector. International Journal of Public Administration, 18, 277-310.
[21] Grout, P.A. and Stevens, M. (2003) The Assessment: Financing and Managing Public Services. Oxford Review of Economic Policy, 19, 215-234.
[22] UNESCO (2000) Incentive Schemes for Promoting Girls Education in Pakistan. UNESCO Pakistan
[23] World Bank (2008) Democratic Republic of Congo Economic Report. Fall 2008, World Bank, Washington and Kinshasa.
[24] Lamont, J. and Favor, F. (2007) Distributive Justice. Stanford Encyclopedia of Philosophy.
http://plato.stanford.edu/entries/justice-distributive/


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AFP/AFP/Getty Images
Paul Ryan Voted For Donald Trump Already & Twitter Is Ready To Hold Him Accountable
by Jen McGuire
House Speaker Paul Ryan has a real case of the frenemies going on with Republican presidential nominee Donald Trump. On the one hand, he's been incredibly public with his criticism of Trump and basically every foolish, racist, sexist thing the man says. On the other hand... he voted for him anyhow. While the whole exchange reminds me of that year in grade five when my best friend and I carried on a tumultuous love/hate thing, social media is having none of it. Paul Ryan already voted for Donald Trump, and Twitter is already experiencing some (unsurprisingly) strong feelings about it.
Ryan has spent the last few months informally renouncing Donald Trump and the horrific vitriol that seems to spew, unbidden, from his mouth whenever it happens to be open (which is all the time), but continuing to back him politically in the presidential election. Back in August, when Trump famously made a super hilarious joke about how the "Second Amendment" people could do a little something about Democratic nominee Hillary Clinton to keep her from nominating a new Supreme Court justice (noting, "If she gets to pick her judges ― nothing you can do, folks. Although, the Second Amendment people. Maybe there is. I don't know"), Ryan responded by saying;
I hope he clears it up very quickly. You should never joke about something like that.
Trump never cleared it up, of course.
Scott Olson/Getty Images News/Getty Images
A few months later, after Trump's now-infamous Access Hollywood hot-mic tape was released (in which Trump could be heard joking about "grab[bing women] by the pussy" and making sexual advances on women without their consent), Ryan seemed totally finished with the Republican nominee, canceling a rally appearance the two were meant to hold together in Wisconsin that week, and writing in a statement,
I am sickened by what I heard today. Women are to be championed and revered, not objectified. I hope Mr. Trump treats this situation with the seriousness it deserves and works to demonstrate to the country that he has greater respect for women than this clip suggests. In the meantime, he is no longer attending tomorrow's event in Wisconsin.
And yet, once again, Ryan failed to retract his official endorsement of the candidate.
Regardless of all the times Ryan has seemingly been ready to throw in the towel, he told Fox News this week that he has already voted for Trump. "I stand where I've stood all fall and all summer," he said. "In fact I already voted here in Janesville for our nominee last week in early voting. We need to support our entire Republican ticket."
While Ryan might have conveniently forgotten the months he has spent calling Trump a racist (when Trump claimed Judge Gonzalo Curiel should not preside over the Trump University lawsuit because of his Mexican heritage), an anti-Semite (Trump shared a picture on Twitter of Hillary Clinton with a Star of David that was later revealed to have been planted by White Supremacists), and most recently, when the Trump Tapes were released, telling fellow Republicans he would simply no longer defend Trump, Twitter has not forgotten.
Sure, Ryan has made it abundantly clear that he has genuine concerns about Trump, but he has always pulled back just shy of saying he would not vote for him, most likely because of pressure within the party to toe the line. Republican Rep. Jim Bridenstine of Oklahoma told MSNBC just a few weeks ago:
Given the stakes of this election, if Paul Ryan isn't for Trump, then I'm not for Paul Ryan.
The problem: Ryan could very well lose his own career along the way. But people are sick of all the vacillating (Trump bad? Trump good?) and more than ready to take to Twitter to let Ryan know they're not happy that he appears to be choosing partisanship over patriotism:
So why is Ryan voting for Trump despite the months of criticizing him and distancing himself from him? To avoid a Clinton presidency, apparently. Ryan told Fox News that he did not want another Clinton administration to happen because,
This is what life with the Clintons looks like … it's always one scandal after another. You never know what's coming next.
Whereas a Trump presidency is certain to run as smooth as butter, I'm sure.


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text:
/ The Floor is Lava Game
The Floor is Lava Game
The Floor is Lava game is based on a concept many kids have played as children. In the made up version of this game, players jump all over the furniture trying to stay off the pretend lava floor. In the actual game, instead of jumping on furniture, kids jump on colored foam tiles.
Game play is easy to follow with 2-6 players first choosing a tile to stand on, and then spinning the spinner and having to jump to a tile of the color the spinner lands on. The last player to reach safety/the correct colored tile, has their previous tile removed from the game.
Game play continues in this fashion so eventually there are fewer and fewer tiles to jump to. If a player touches the ground at all, he or she is out. As players and tiles get eliminated, the game gets more exciting.
An addition to the game is that some of the tiles feature question marks on them, which represent challenges. If a player lands on a tile with a question mark, they must pick a challenge card and complete that challenge without touching the floor to stay in the game.
This great game is best with 2 to 6 players who are ages 5 years old and up. Boys and girls alike will enjoy this game which comes with 25 colored foam "safety stones", 27 challenge cards, game spinner, and instructions.


text:
Pricing children out of their rights by Charlotte Rubin
16/11/19 14:42 Filed in: Registering as British
Summary: Children's rights are not for the Home Office to block, and no child should be prevented from securing British citizenship to which they are entitled by law. On Tuesday November 26th, the first day of a court case challenging the lawfulness of the Home Office fee of £1,012 for a child to register as a British citizen, Amnesty International will be protesting outside the Royal Courts of Justice to visually demonstrate significant support for the children affected by this government profiteering. Show your support and join them.
The Secretary of State, on his British citizenship application form guide, outlines the importance of British citizenship to an individual:
"Citizenship is a 'significant life event'. Apart from allowing a child to apply for a British citizen passport, British citizenship gives them the opportunity to participate more fully in the life of their local community as they grow up."
The British Nationality Act 1981 ensures that children who grow up in the United Kingdom (either UK-born or not), who feel just as British as their British-born friends, have rights to register as British citizens. Failure to register means one is excluded not only in the present, for example because they are not allowed to go on certain school trips, but will also continue to be marginalised in the future, when it comes to obtaining all the perks which come with British citizenship, including the right to remain, the right to vote in all elections, access to public funds, health services, and other social benefits.
Registration is fundamentally different from naturalisation, which is the process adult migrants need to go through in order to acquire citizenship. The essential difference is the role of the Home Office when processing the applications. In naturalisation cases, that role is to decide, at the Home Office's discretion and balancing all relevant factors, whether the applicant should be made a British citizen. Contrastingly, in registration cases, it is simply to recognise a pre-existing right to citizenship laid out in statute.
Academic researchers have estimated there to be around 120,000 children in the UK without British citizenship, around 65,000 of whom were born in the UK. However, many of these children do not register for citizenship, not because they are not eligible, but simply because they cannot afford to. Since 2007, the Home Office have started charging applicants more than the administrative cost of processing the application, aggravating the situation. The Home Office states that the fee, currently priced at £1,012 is made up of two parts: £372 for the administrative cost of processing registration, and £640 as a profit element to finance the immigration system. In other words, the Home Office is profiting off children who are merely claiming what is rightfully theirs, and they are making twice as much profit as the actual cost price.
In practice, the Home Office fee hinders children in exercising their rights under the 1981 Act. This sort of exclusionary policy not only jeopardises a child's start in life; it also undermines their future. Ultimately, if a child is unable to pay the £1012 fee today, that may well be the reason why that same child cannot afford to go to university eight years from now, because they cannot get a student loan. In addition, their children won't be recognised as British either, even if they are the second or third generation in their family born and brought up in the UK.
This outrageously discriminatory Home Office policy needs to stop. Children's rights are not for the Home Office to block because of finances, and no child should be prevented from securing their British citizenship. In order to allow children to exercise the rights which were conferred upon them by Parliament, the Home Office fee should be reduced; the profit element of the fee should be removed altogether. In addition, for people from disadvantaged backgrounds, public funds should be made available to cover the fee in full. Children should not have to raise funds to pay for their registration rights, particularly where these rights are by entitlement. That is why the Project for the Registration of Children as British Citizens (PRCBC), a London-based charity which fights for British citizenship rights of children born in the UK to migrant parent(s), is challenging the lawfulness of the Home Office fee in court.
PRCBC's case is centred on challenging the Home Office's flawed, quid pro quo argument on which they rely to justify the elevated fee. The basic premise of their approach is that those who are profiting from the immigration system, should also be paying for it. However, since these children are merely asking for recognisance of their entitlement, their applications for registration fall outside of immigration law and policy. Registering as a British citizen is not a benefit the Home Office grants these children. Rather, it is a recognition of a right these children already have by law. Therefore, they are not profiting from the system, and it is only natural that they should not be made to pay for it.
British citizenship, especially for children and young adults, is about much more than just getting the right documents. It is about identity, integration, a sense of belonging, and about confirmation that the UK is their home. It is about having the same rights, feeling part of their peer group and much more. That is why on Tuesday 26 November, the second day of the PRCBC proceedings, Amnesty will be protesting outside the Royal Courts of Justice to visually demonstrate significant support for PRCBC and for the children affected by this government profiteering.
Show your support and join them.
Tags: Children, Registering as British, Citizenship


After successfully launching i3 and i8, BMW has rolled out a lifestyle accessories line-up based on the 'i' sub-brand. Named the 'BMW i collection', the accessories stick to the eco-friendly character marked by the Bavarian automaker's i-brand sharing the same vision. Unlike the usual accessory collections launched by luxury carmakers exhibiting panache and opulence, the BMW i collection has premium yet utilitarian and everyday items in the list.
Items from the BMW i collection like the urban mega-shopper bag, laptop bag, and notebook are made from sustainable and modern materials including leather tanned using olive leaves and a felt-look fabric made from recycled PET. The BMW i notebook is accompanied with a BMW i ball-point pen and all the items are highlighted with the color blue and have BMW i insignia marked on it.
Other items from the BMW i collection include matt-aluminum finished 16GB USB drive, BMW i solar charger that can charge MP3 players and mobile phones and BMW i keyfobs and lanyards. The i-edition accessories will go on sale from October 2013 onwards with prices ranging from €15 ($20) for the pen or lanyard to €99 ($135) for the urban shopping bag.


The Pre-Star Program (Pre-Star) is a program that serves as a transition between CanSkate and STARSkate. This program offers the perfect blendof a dynamic group program along with an introduction to the sport of figure skating. It is geared to skaters who show an interest in figure skating and have a basic skating background. Skaters are typically on CanSkate Stage 4 badge or have been recommended by coaches to move up. Pre-Star provides both parents and skaters an opportunity to be introduced to figure skating in a group lesson format. There will be an emphasis on edgequality and stroking in this program.
In this program, skaters will continue to complete their CanSkate levels dring their Pre-Star CanSkate session, as well as be introduced to all disciplines of figure skating in their Pre-Star enrichment class. The goal is to have the skaters pass Level 4 by the end of the first year and Level 5 by the end of the second year. These arethe general goals; however, each skater is different and factors such as the frequency and duration of lessons attended will impact how quickly skaters will attain these goals. In the Pre-Star program coaches will monitor progress on an ongoing basis. Ribbons and badges will be given out as they are earned. Report cards will be completed in December and March. However, skaters are instructed on what they should focus on to complete their level throughout the season. When a skater is ready for the STARSkate program the skaterand parent will be advised. Please refer to the STARSkate section for more information.
The Pre-Star program includes an enrichment class for those registered in the Pre-Star are provided within group lessons in a low ratio format by a certified coach. Coaching fees are included in the registration fees. There are 20 minutesof group lessons. The coaches will focus on introducing skaters to all the disciplines of figure skating including stroking, dance, skills and freeskate.
Note: Parents may opt to arrange private lessons for their skater to occur before their group session by purchasing the Pre-Star Private lesson package. For this package a minimum of 15 minutes with a private coach is required. Please note private lesson fees are not included in the skater's registration fee and will be billed to the student directly by their private coach. See how to choose a base coach in our MSC Handbook Final.pdf.
Proper clothing is required for all MSC programs.
It is recommended that skaters in the introductory program wear figure skates.


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Today's News & Commentary — April 8, 2019
by Martin Drake | Apr 8, 2019 | News & Commentary
The Wall Street Journal editorial board argued yesterday that the "Fight for $15" could lead to fewer jobs and increased crime. The paper bases its jobs findings on a two-month drop in restaurant employment in New York City after a wage increase from $13 to $15 per hour; the argument on crime comes from a National Bureau of Economic Research working paper that studied the correlation between minimum wage increases and crime from 1998 to 2016. The editorial board also asserts that a study of Seattle's recent minimum wage increase shows that higher minimum wages can lock unskilled workers out of the job market. That same study shows that workers on the whole worked less hours but received the same take-home pay, CNN reports.
Democrats are threatening to block the new NAFTA agreement unless Mexico passes improved workers' rights legislation, Reuters reports. A current bill in the Mexican legislature would realize the Democrats' desired labor standards, including increased democracy in workers' organizations, according to a recent Bloomberg article on the topic. The bill requires that workers vote to approve their unions, delegates, and contracts by secret ballot. Many blame lax Mexican labor protections for the decision of many U.S. companies to set up factories just south of the U.S. border while closing their U.S.-based plants. Meanwhile, significant labor unrest continues at those very factories in northern Mexico, often referred to as "maquiladoras."
Representatives of the Writers Guild of America have decided to extend their negotiations with talent agents for another week, the New York Times reports. TV writers affiliated with the union claim that the major talent agencies have been enriching themselves at the writers' expense. The two parties have been operating under an agreement dating back to 1976 which was set to expire over the weekend; the new extension will last until April 13 as the two sides attempt to work out their ongoing dispute.
Labor unions are cautiously engaging in the 2020 Democratic primary race, after being burned by their pick in 2016, the Los Angeles Times reports. In 2016 labor leaders endorsed Hillary Clinton over the more pro-union Bernie Sanders, in an effort which they hoped would galvanize their membership but instead became divisive in several big unions. This time around, unions are making efforts to get their rank and file more invested in the 2020 race. The American Federation of Teachers, for example, is changing its endorsement process to seek more input from members after the union's early 2016 endorsement of Clinton led to a significant membership revolt.
Martin Drake
Martin Drake is a student at Harvard Law School.More by this Author »


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Sky Ferreria attempts to conquer her fears with intimate show at The Belmont
Word started to spread via social media early on Sunday afternoon that Sky Ferreria's 6 p.m. slot on the Blue Stage at Fun Fun Fun Fest was being scrapped due to a flight delay. An alternate set was immediately scheduled for 9:30 tonight at the Belmont. Moved from a festival stage to a much more intimate show, it was a total upgrade for fans.
When the lights went down at 9:30 on the nose, the venue was still only about half full. Sky took the stage in a giant parka, with the hood still up and thanked the audience for coming "despite the change." Her band started to play "24 Hours," but a little more than halfway through the song, she stopped them and asked to start over because she was having trouble hearing her in-ear monitor. "I'm gonna fix this show," she exclaimed before giving the song a second attempt.
There were a few minor stumbling blocks as the show continued, but she soldiered on feeding off the energy of her dedicated fans. The setlist was predominately comprised of tracks from her debut album "Night Time, My Time." One of last year's best pop records, she hit the audience with 9 tracks from the record. By the time she finished "Ain't Your Right," the evening's second song, the Belmont had filled in from front to back and Ferreria seemed to find her footing.
As somebody who has recently toured worldwide on an arena tour opening up for Miley Cyrus, it's a little surprising that she still lacks full confidence in herself on stage. Even with the adoration and screaming of fans, the fact that she never took her giant coat off was a big indicator that she isn't quite ready to fully commandeer a stage. That said, she never stopped trying and her awkwardness is at least part of what makes her so endearing ("I almost drank the microphone," she muttered after mistaking which hand her water bottle in).
For each moment where she experienced some shaky live vocals (usually in songs that had no backing track vocals to help guide her), she responded in kind with songs like "Heavy Metal Heart" where she belted out the chorus like her life depended on it, determined to prove that she could she really sing. Another highlight of the set was the single "You're Not The One," which found the crowd singing along at the top of their lungs. The only two songs performed that weren't from her debut full-length were both from her 2012 "Ghost EP: "Lost In My Bedroom" and the epic set closer "Everything Is Embarrassing."
The show was over almost as quickly as it was set up. Within an hour, she was off the stage and whisked away. The crowd was primed for an encore, but all we got was her keyboard player coming back out and dancing oddly on stage to a remix of "You're Not The One." As the house lights rose to indicate that an encore was out of the question, the general feeling was one of relief that the show went on at all.
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text:
Bødlen som offer er en dansk dokumentarfilm fra 1994, der er instrueret af Jørgen Flindt Pedersen efter manuskript af Erik Stephensen.

Handling
Var du en god torturbøddel? - "Ja, det tror jeg!" I 1982 lavede Jørgen Flindt Pedersen og Erik Stephensen filmen Din nabos søn om torturbødler i Grækenland under juntastyret 1967-74. 13 år efter opsøges de samme mennesker, der for altid bærer på en tung byrde, men som lever videre. Skal leve videre. Ofre og bødler sammen. Og filmen interviewer disse ofre og bødler, der forsigtigt og smertefuldt taler om fortidens forbandelse, den svære nutid, tilgivelse og børnene - håbet, der søger sandheden. Men der udøves stadig tortur andre steder i verden. Endnu er der ofre og bødler.

Referencer

Eksterne henvisninger

Danske film fra 1994

Film fra Danmark (administrationskategori)
Dokumentarfilm fra Danmark

redpajama_set_name: RedPajamaWikipedia


When irritated face and dilated vessels well to mask a hunter. Properly chopped herbs Hypericum (0.5 spoon) assorted with aqua (1 soup spoon), so add oatmeal and olive oil (1 spoon, too), and butter solutions of vitamin A and E - can be of capsules. All the ingredients are well assorted and applied the mix on a facial skin for 15-20 min, Thoroughly wash off with cold aqua. This mask helps even under severe irritation, while nourishing and moisturizing the skin.The mask of irritation with a egg and natural butter: with? yolk mix up TWO tsp. A fruit breeding juice (like pomelo), add a same amount of fat cottage cheese and 1 tsp. Vegetable oil. All ingredients are comfortably mix and applied on the face for 20 minutes. Ablution off a cover with cold water.The mask of sour fluid (cream, fat cheese) and the recent melon extract too speedily relieves irritation. Sour serum and fruit extract (TWO teaspoon) assorted with olive oil (1 tsp.), use the mixing on a face for 20 min and wash off with hot h2o.Anti-inflammatory covers are not only good for cleansing the face, but also soothes irritated. Helf mask of aloe and eggs white. A fleshy leaves of aloe ground to pulp, mixed with beaten eggs whites and add to the grapefruit fresh juice - a few drops. The cover is used to facial skin gradually in several layers, where each layer dries. When the last layer is completely very dry, wash out off the mask with soft water. Instead, you can apply a pulp of aloe good fresh juice of a fruit.Cover yeast skin irritation: dry yeast (10 g) is mix with fluid (1 soup spoon) and other fermented milk product, the breeding juice was added some psyllium or the berries. Give a little to stand up and put on a skin; hold until very dry up. Washing off with warm water, massaging movements.Fresh juice and plantain leaves generally had help with a inflammation of a skin. You can do a mask with sweet or dried leaves of plantain and nettle. Herbs taken in equal parts, mixed with grapefruit breeding juice and combine gently used to a affected skin. Hold for 10-Fifteen minutes and washing off with cool h2o.A cover redness of a skin with parsley and sour cream: finely chop a parsley and mix with a little quantity of sour fluid, and put on Fifteen minutes reddened and irritated areas. Wash off with warm water. It is possible to use a fresh juice of parsley - no sour: you possess to soak gauze and used to the issue areas. The course is 10 sessions - It is possible to repeat them every other time.Cover for sensitive skin as well soothe irritation and get a beneficial effect on a facial skin how a whole. If the facial skin is highly sensitive, the mask want be applied immediately, but 1st try on a little space of?? face if you feel even a some discomfort or slight burning, a mask want be water-washed off immediately. In such covers are frequently used cottage cheese, milk, cucumbers or potatoes. Cucumber and dumplings is almost never cause unwanted reactions.A most simple - lubricate face serum cottage cheese and put on top of slices of fresh cucumber. You can make more sophisticated cover by mixing cheese with recent cucumber, grated on a great grater - 1:1. It is possible to apply cucumber instead of grated carrot or big banana. To have a nutritional mask, can be added to a mixture of olive butter.Same posts: Skin care '32 Right face Facial cream.


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Mass use of encrypted messaging apps doesn't hamper security: Harvard study
There has been an increased awareness of online security tools among lay persons in the post-Snowden era.
Kim Arora
NEW DELHI: Sending text messages securely doesn't require advanced technical expertise anymore. Apps like Telegram, Signal, Surespot, etc -- some of which have been reportedly used by ISIS operatives too -- have made it as easy as downloading an app and going about business as usual. But does a growing uptake of encryption by the masses hinder the job of investigating agencies? A recent study from Harvard University's Berkman Center for Internet and Society says, no.
There has been an increased awareness of online security tools among lay persons in the post-Snowden era. Berlin-based encrypted messaging app Telegram, for example, has over 50 million downloads on Google Play Store alone. Signal, another secure messaging and calling app has over 1 million downloads on Android. These provide end-to-end encryption for messages sent over their network. This means, that the message is as good as under lock and key as it travels from sender to recipient, difficult or impossible to intercept by anyone except the person receiving the message on their own device. Apple's iMessage, which does exactly this on the iPhone, has been a point of contention between the Cupertino-based tech giant and the US government when it comes to surveillance.
Apple has resisted the The US Federal Bureau of Investigation's requests to access the contents of messages shared through the app since early 2015. The FBI argued it needed that data for effective policing, while Apple reasoned that the nature of the encryption was such that a "backdoor" for government access would defeat the purpose, and compromise privacy of its users. The conflict has only intensified after Apple once again resisted FBI's efforts to disable a security feature to unlock an iPhone for the investigation of a terror attack by ISIS sympathisers in San Bernardino.
This isn't the first time the FBI raised concerns about encryption. Back in 2010, its then counsel general Valerie Caproni had expressed apprehensions about law enforcement "going dark" or drawing a blank with lawful surveillance tactics because of these new communication channels. The Harvard study released earlier in February, titled "Don't Panic: Making Progress on the Going Dark debate", cites numerous factors to state the opposite. Chief among these are: the financial unfeasibility of internet companies offering end-to-end encryption of messages on their platform, the growing use of the "internet of things," and the non-encryption of metadata.
iPhone encryption: FBI says Apple's arguments 'false'
The use of secure messaging, just like Skype, Facebook, or Twitter, isn't limited to sharing cat gifs and topical jokes. Services like YouTube and Twitter are engaged in a constant game of whac-a-mole with such accounts allied to terror group ISIS, shutting them down even as new ones spring up. Just last month, the terror organisation launched an encrypted messaging app called Alrawi to evade snooping investigators. Telegram tried damage control by banishing ISIS operatives from its platform. Rajasthan-based Mohd Sirazuddin, arrested in December for ISIS links, also reportedly used the app to stay in touch with handlers.
A senior home ministry official, speaking to TOI on condition of anonymity, said these challenges were not "insurmountable" for an investigating agency. "ISIS operatives have been using encrypted messaging apps like Trillian, Telegram and Surespot. But we have our own ways to handle end-to-end encryption. Different countries have different laws for retaining and disclosing data, which can be obtained by local investigating agencies after following legal procedures," said the official.
The Harvard researchers offer a more detailed explanation: "Although use of encryption may present a barrier to surveillance, it may not be impermeable…encryption does not prevent intrusions at the end points, which has increasingly become a technique used in law enforcement investigations. Encryption typically does not protect metadata, such as e-mail addresses and mobile-device location information that must remain in plaintext to serve a functional purpose. Data can also be leaked into unencrypted media, through cloud backups and syncing across multiple devices."
The study expects the "internet of things" -- an umbrella term used to refer to devices such as microwaves, curtains, doors, and lamps connected to and controllable over the internet -- to drastically alter the surveillance landscape. "The still images, video, and audio captured by these devices may enable real-time intercept and recording with after-the-fact access," it points out.
A widespread adoption of encryption practices, says Data Security Council of India head Nandkumar Saravade, is actually good for general security. "Flaws in security design are used more by malicious actors than law abiding citizens," says Saravade, pointing out that security breaches and unlawful snooping on citizens and government agencies by non-state actors can be avoided with secure communication protocols.
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text:
Effect of Calcination Temperature on the Structure and Catalytic Properties of MnOx/Ca2O3 in the Reaction of CO and Ethane Oxidation
S. S. Sigaeva, T. N. Afonasenkova, O. A. Bulavchenko, T. I. Gulyaeva, E. A. Anoshkina, P. G. Tsyrul'nikov
Научно-образовательный центр энергоэффективного катализа НИЧ
Лаборатория структурной диагностики ультрадисперсных и наноструктурированных систем ФФ
Кафедра физических методов исследования твердого тела ФФ
Effect of the calcination temperature of the MnOx/Ga2O3 system on its structural and catalytic properties in the reaction of oxidation of CO and hydrocarbons. The dependences of the catalytic activity of MnOx/Ga2O3 in the reactions of CO and ethane oxidation on the calcination temperature exhibit an extremal behavior. The maximum values of activity are observed upon calcination of the system at 700°C, i.e., at the temperature that is limiting for the existence of a solid solution of manganese ions in γ-Ga2O3. The structural changes occurring with increasing calcination temperature are accompanied by a substantial decrease in the specific surface area of a sample. The observed rise in the specific catalytic activity (by a factor of ~7 upon an increase in the preliminary-calcination temperature from 600 to 800°C) confirms that the thermal activation effect exists for the given system.
Russian Journal of Applied Chemistry
Опубликовано - 1 дек 2017
Fingerprint Подробные сведения о темах исследования «Effect of Calcination Temperature on the Structure and Catalytic Properties of MnOx/Ca2O3 in the Reaction of CO and Ethane Oxidation». Вместе они формируют уникальный семантический отпечаток (fingerprint).
Ethane Химические соединения
Carbon Monoxide Химические соединения
Calcination Химические соединения
Oxidation Химические соединения
Catalyst activity Химические соединения
Temperature Химические соединения
Manganese Химические соединения
Hydrocarbons Химические соединения
Sigaeva, S. S., Afonasenkova, T. N., Bulavchenko, O. A., Gulyaeva, T. I., Anoshkina, E. A., & Tsyrul'nikov, P. G. (2017). Effect of Calcination Temperature on the Structure and Catalytic Properties of MnOx/Ca2O3 in the Reaction of CO and Ethane Oxidation. Russian Journal of Applied Chemistry, 90(12), 1918-1925. https://doi.org/10.1134/S1070427217120047
Sigaeva, S. S. ; Afonasenkova, T. N. ; Bulavchenko, O. A. ; Gulyaeva, T. I. ; Anoshkina, E. A. ; Tsyrul'nikov, P. G. / Effect of Calcination Temperature on the Structure and Catalytic Properties of MnOx/Ca2O3 in the Reaction of CO and Ethane Oxidation. В: Russian Journal of Applied Chemistry. 2017 ; Том 90, № 12. стр. 1918-1925.
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title = "Effect of Calcination Temperature on the Structure and Catalytic Properties of MnOx/Ca2O3 in the Reaction of CO and Ethane Oxidation",
abstract = "Effect of the calcination temperature of the MnOx/Ga2O3 system on its structural and catalytic properties in the reaction of oxidation of CO and hydrocarbons. The dependences of the catalytic activity of MnOx/Ga2O3 in the reactions of CO and ethane oxidation on the calcination temperature exhibit an extremal behavior. The maximum values of activity are observed upon calcination of the system at 700°C, i.e., at the temperature that is limiting for the existence of a solid solution of manganese ions in γ-Ga2O3. The structural changes occurring with increasing calcination temperature are accompanied by a substantial decrease in the specific surface area of a sample. The observed rise in the specific catalytic activity (by a factor of ~7 upon an increase in the preliminary-calcination temperature from 600 to 800°C) confirms that the thermal activation effect exists for the given system.",
keywords = "MANGANESE, MN1.5AL1.5O4, ACTIVATION, SPINEL",
author = "Sigaeva, {S. S.} and Afonasenkova, {T. N.} and Bulavchenko, {O. A.} and Gulyaeva, {T. I.} and Anoshkina, {E. A.} and Tsyrul{\textquoteright}nikov, {P. G.}",
journal = "Russian Journal of Applied Chemistry",
publisher = "Maik Nauka-Interperiodica Publishing",
Sigaeva, SS, Afonasenkova, TN, Bulavchenko, OA, Gulyaeva, TI, Anoshkina, EA & Tsyrul'nikov, PG 2017, 'Effect of Calcination Temperature on the Structure and Catalytic Properties of MnOx/Ca2O3 in the Reaction of CO and Ethane Oxidation', Russian Journal of Applied Chemistry, том. 90, № 12, стр. 1918-1925. https://doi.org/10.1134/S1070427217120047
Effect of Calcination Temperature on the Structure and Catalytic Properties of MnOx/Ca2O3 in the Reaction of CO and Ethane Oxidation. / Sigaeva, S. S.; Afonasenkova, T. N.; Bulavchenko, O. A.; Gulyaeva, T. I.; Anoshkina, E. A.; Tsyrul'nikov, P. G.
В: Russian Journal of Applied Chemistry, Том 90, № 12, 01.12.2017, стр. 1918-1925.
T1 - Effect of Calcination Temperature on the Structure and Catalytic Properties of MnOx/Ca2O3 in the Reaction of CO and Ethane Oxidation
AU - Sigaeva, S. S.
AU - Afonasenkova, T. N.
AU - Bulavchenko, O. A.
AU - Gulyaeva, T. I.
AU - Anoshkina, E. A.
AU - Tsyrul'nikov, P. G.
N2 - Effect of the calcination temperature of the MnOx/Ga2O3 system on its structural and catalytic properties in the reaction of oxidation of CO and hydrocarbons. The dependences of the catalytic activity of MnOx/Ga2O3 in the reactions of CO and ethane oxidation on the calcination temperature exhibit an extremal behavior. The maximum values of activity are observed upon calcination of the system at 700°C, i.e., at the temperature that is limiting for the existence of a solid solution of manganese ions in γ-Ga2O3. The structural changes occurring with increasing calcination temperature are accompanied by a substantial decrease in the specific surface area of a sample. The observed rise in the specific catalytic activity (by a factor of ~7 upon an increase in the preliminary-calcination temperature from 600 to 800°C) confirms that the thermal activation effect exists for the given system.
AB - Effect of the calcination temperature of the MnOx/Ga2O3 system on its structural and catalytic properties in the reaction of oxidation of CO and hydrocarbons. The dependences of the catalytic activity of MnOx/Ga2O3 in the reactions of CO and ethane oxidation on the calcination temperature exhibit an extremal behavior. The maximum values of activity are observed upon calcination of the system at 700°C, i.e., at the temperature that is limiting for the existence of a solid solution of manganese ions in γ-Ga2O3. The structural changes occurring with increasing calcination temperature are accompanied by a substantial decrease in the specific surface area of a sample. The observed rise in the specific catalytic activity (by a factor of ~7 upon an increase in the preliminary-calcination temperature from 600 to 800°C) confirms that the thermal activation effect exists for the given system.
KW - MANGANESE
KW - MN1.5AL1.5O4
KW - ACTIVATION
KW - SPINEL
JO - Russian Journal of Applied Chemistry
JF - Russian Journal of Applied Chemistry
Sigaeva SS, Afonasenkova TN, Bulavchenko OA, Gulyaeva TI, Anoshkina EA, Tsyrul'nikov PG. Effect of Calcination Temperature on the Structure and Catalytic Properties of MnOx/Ca2O3 in the Reaction of CO and Ethane Oxidation. Russian Journal of Applied Chemistry. 2017 Дек. 1;90(12):1918-1925. https://doi.org/10.1134/S1070427217120047


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Phoebe Jones
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By Phoebe Jones
What is Enigma?
The Enigma machine is a piece of hardware invented by a German and used by Britain codebreakers as a way of deciphering German signals traffic during World War Two. The Enigma is a device which scrambles a plain text message into a ciphered text. It was used solely to encipher and decipher messages. It consisted of a keyboard of 26 letters in the pattern of the normal German typewriter, but with no keys for numerals or punctuation. Behind the keyboard was a lampboard made up of 26 small circular windows, each bearing a letter in the same pattern as the keyboard, which could light up one at a time. Behind the lampboard is the scrambler unit consisting of a fixed wheel at each end, and a central space for three rotating wheels. If a key was pressed on the keyboard any other letter could light up, and the sequence would only repeat itself after 16,900 (26x25x26) keyings, when the inner mechanism returned to the same position. Messages were limited to a maximum of 250 letters to avoid this recurrence, which might have otherwise helped the British code-breakers.
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Auckland, New Zealand, 16 June 2008 – Tenon, a wood products processing, marketing, and distribution business, gave the following operational update to the market today.
In its Interim Results, Tenon stated that it would be proceeding "on the basis that market conditions would remain very difficult for the balance of our 2008 fiscal year." This working assumption has proved to be the case, and the usual spring-lift in market conditions in the United States historically weighted the company's financial results to the second half of the fiscal year has not occurred this year. A longer winter and late spring have exacerbated the difficult housing market conditions the sector has been experiencing. In addition, the NZD:USD exchange rate, which averaged 75.5 cents for the first fiscal six months, has strengthened further to average 79 cents for the five months to May of the second half of the fiscal year. Comparing fiscal 2008 to date (i.e. up to the end of May this year) with fiscal 2007, the average exchange rate strengthened from under 69 cents to around 77 cents. As every 1 cent increase in the NZD:USD exchange rate is equivalent to approximately USD 750,000 in lost operating earnings, all other factors being constant, this strengthening has negatively affected the company's earnings year-on-year by approximately USD 6 million in EBITDA.
Although the U.S. housing market conditions and NZD:USD exchange rate are beyond the company's control, Tenon has put in place several key initiatives to address the controllable factors in its business. Tenon has advanced a "one company" platform (OCP) during the period, with the completion of the integration of the back office operations of Empire and FWS being just one example. As a result of a series of clearly identified OCP initiatives of this type, the company is confident that it is on target to achieve its goal of USD 5 million of annualized OCP savings over the next two years. In addition, over the last 12 months, Tenon has optimized its supply chain to match market demand, and reduced overall employee levels by 13% to just over 1200 people. This reduction in workforce has been completed with no degradation of the company's critical success factor: best-in-class service to its customers.
The initial roll-out of Armour Wood and LIFESPAN – Tenon's emerging outdoor products – have been affected by the U.S. housing downturn, but despite those conditions the establishment of these brands is now advancing well. Armour Wood, the company's exclusive outdoor brand for Lowe's, is now present in 150 Lowe's stores, with an agreed further roll-out plan in place.
Overall, the outdoor segment is four times the size of Tenon's traditional moldings category. It offers a considerable scope to build a strong growth platform around treated wood products for outdoor use, which will generate significant future earnings and value benefits for the company.
Taking all these factors into account, Tenon's current expectations are for earnings before interest, tax, depreciation, and unusual items (i.e. EBITDA pre-unusuals) for the 12 months to 30 June 2008 to be in a range of approximately USD 16-17 million. This is in line with current market expectations, and represents a very good performance given the difficult prevailing operating environment and the relative performance of Tenon's competitors.
The company has made excellent progress with its working capital management, particularly in terms of adjusting its inventory levels to the lower level of market activity currently being experienced, while also ensuring that it meets customers' high order-fulfilment requirements. This focus, combined with strong cash generation across the company, should see Tenon's net interest bearing debt (including all deferred liabilities and mortgages) fall from USD 88 million at 30 June 2007 to around USD 75 million by 30 June 2008.
From 01 July 2008 (the beginning of the new fiscal year), Tenon's debt levels will be able to be significantly reduced even further, through the inclusion of some of Tenon's operations within a supply-chain financing program sponsored by the Bank of America. The program will allow Tenon the opportunity to receive payment from Bank of America for a large portion of its receivables well in advance of normal customer credit payment terms.
Tenon's bank syndicate has approved Tenon's entry into the program, on the condition that the bank facility size is reduced by USD 20 million, reflecting the approximate debt reduction expected to result for Tenon from its inclusion in the program. As Tenon's goal has been to operate to a lower level of debt (and therefore to a lower use of total facilities) through this point in the business cycle, this requirement is consistent with the company's intent and has been agreed to.
Under the program (which is nonrecourse to Tenon), Tenon will receive 100% of the face value of the receivables bought by Bank of America, less a financing fee that will represent the interest cost for the early receivables payment. As the program has a higher credit rating than Tenon's bank facility, the program is an economically attractive initiative for Tenon. The company said it would next update the market on its performance and operating conditions at its full-year results release in August.


Eka's Portal • View topic - What preds do you like for pre-vore scenes? Why?
What preds do you like for pre-vore scenes? Why?
What preds do you like for pre-vore scenes? And why do you find these arousing? What do you like about the fact that you have not been eaten yet, but know that you are going to be eaten?
Like for me, my favorite pre-vore pred is Ho-oh. I like the idea of her finding me shrunken, she grabs me with her wing and holds me above her open mouth with that hungry look. However, I do not typically imagine the scenario to her stomach but do imagine that is where I will end up and that is why she is a pre-vore pred for me.
My wife Reshiram is also a pre-vore pred, but I imagine the scenario all the way through digestion. However, Ho-oh tops her for just 'pre-vore'.
Re: What preds do you like for pre-vore scenes? Why?
I imagine every pred I fancy would do mouth play or at least do something like licking their lips or mouthwatering on prey(s) by accident. I'm more of a pred myself however.


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Will Among Us Come To Xbox
Xbox has been around for over a decade and a half at this point and it doesn't look like it will be going away any time soon. Microsoft has continued to update and improve their gaming console, making it one of the most popular gaming devices on the market.
However, there is one thing that Xbox has been lacking in comparison to its competitors- a strong social media presence. While Playstation and Nintendo have been thriving on platforms like Twitch and YouTube, Xbox has been largely absent.
Fans of Xbox have been hoping that Microsoft will begin to focus more on social media in order to better compete with its rivals. And it looks like their prayers may have been answered, as Microsoft has announced that they are working on a new streaming service called 'Will Among Us Come To Xbox'.
Details about the service are still scarce, but it is expected to be a streaming platform that will allow users to watch and interact with other gamers online. It is also expected to include a 'community hub' where users can share tips, tricks, and other content related to Xbox gaming.
Microsoft has not released a date for the launch of the service, but it is expected to be released sometime in 2020. Xbox fans are eagerly awaiting its arrival, and it is sure to be a huge hit among gamers worldwide.
1 Is Among Us coming to Xbox console?
2 Will Among Us be free on Xbox?
3 Is Among Us coming to Xbox in 2021?
4 Is Among Us coming to Xbox tomorrow?
5 What time will Among Us come to Xbox?
6 Is Among Us 2 confirmed?
7 What time is Among Us release on Xbox?
Is Among Us coming to Xbox console?
Among Us is an upcoming game that is currently in development for PC. The game is a cooperative multiplayer game where players must work together in order to survive. There is no word yet on whether or not the game will be coming to Xbox consoles, but many gamers are hoping that it will.
Among Us is a game that is all about cooperation. Players must work together in order to survive in a world that is full of zombies. The game features a number of different missions, each of which presents its own unique challenges. The game also features a variety of different weapons, which players can use to take down zombies.
Read also Will Elden Ring Be On Xbox Series X
So far, the game has received mostly positive reviews. GameSpot, for example, gave the game an 8 out of 10, praising its "high level of polish" and its "engaging cooperative gameplay."
Many gamers are hoping that the game will come to Xbox consoles. The Xbox One, in particular, is in need of more cooperative multiplayer games. Games like Halo 5 and Gears of War 4 are great, but they can be a little bit lonely at times. It would be great to see a game like Among Us come to the Xbox One, as it would add some much-needed variety to the console's library.
At the moment, there is no word on whether or not Among Us is coming to Xbox consoles. However, the developers have not ruled out the possibility, and they are certainly open to the idea. So, it is possible that the game could come to Xbox One in the future. We'll just have to wait and see.
Will Among Us be free on Xbox?
Xbox has been a popular gaming platform for a while now, with many people enjoying the exclusive games that are available only on Xbox. However, one question that often comes up is whether the games available on Xbox are going to be free to play.
Currently, there is no definitive answer to this question. Microsoft has not yet announced whether or not games on Xbox will be free to play. However, it is likely that at least some of the games available on Xbox will be free to play. This is because Microsoft has been increasingly emphasizing its services that are available for free, such as its streaming service, Xbox Game Pass.
Xbox Game Pass is a subscription service that allows players to access a library of games for a monthly fee. This service is very popular, and it is likely that Microsoft will want to attract more players to Xbox by making some of the games available on the platform free to play.
However, it is also possible that Microsoft will choose to make some of the more high-end games available on Xbox free to play. This is because Microsoft has been increasing its focus on services that offer premium content, such as its game streaming service, Xbox Live.
Read also Where To Fix My Xbox
Xbox Live is a subscription service that allows players to access a library of games, as well as exclusive content and features. This service is very popular, and it is likely that Microsoft will want to attract more players to Xbox by making some of the games available on the platform free to play.
So, will games on Xbox be free to play? At this point, it is difficult to say for certain. However, it is likely that at least some of the games available on Xbox will be free to play.
Is Among Us coming to Xbox in 2021?
There has been a lot of speculation surrounding the release of 'Is Among Us' on Xbox. Some believe it may come as early as 2021, while others believe it may take a little longer. However, no official statement has been released as to when the game will be available on Xbox.
The game has already been released on PC and Playstation 4, and has been well-received by gamers and critics alike. Some have even called it the 'best game of the year'. The game is a first-person shooter set in a post-apocalyptic world, and has been praised for its immersive gameplay and stunning graphics.
There is no doubt that the game would be a huge hit on Xbox, and fans of the game are eagerly awaiting its release. However, it is still unclear when that will be. Hopefully, we will get some news soon!
Is Among Us coming to Xbox tomorrow?
The game has been available on Steam for a while now, but according to a recent tweet, Among Us may be coming to Xbox One tomorrow.
The game is a multiplayer party game in the vein of games like Towerfall and Gang Beasts. Up to eight players can join in on the fun, either locally or online.
The game has received mostly positive reviews on Steam, with users praising its simple, but fun, gameplay.
It's unclear if the Xbox One version will include any additional content or features, but we should know more soon.
What time will Among Us come to Xbox?
The much anticipated Among Us, a game that has been in development for years, is finally coming to Xbox. The game is a unique blend of adventure and survival, set in a post-apocalyptic world.
Read also Is Minecraft Free On Xbox
Among Us is set to release on Xbox on November 22. The game has been in development for years, and has been through numerous alpha and beta tests. The final version promises to be the best yet, with new features, tweaks, and optimizations.
Among Us is a unique blend of adventure and survival. In the game, you must find supplies, build shelter, and fight off zombies in order to survive. The game is set in a post-apocalyptic world, which provides a unique and exciting setting.
Among Us will be released on Xbox on November 22. The game has been in development for years, and has been through numerous alpha and beta tests. The final version promises to be the best yet, with new features, tweaks, and optimizations. If you're looking for an exciting and unique adventure game, be sure to check out Among Us when it releases on Xbox on November 22.
Is Among Us 2 confirmed?
There has been much speculation over the past few months about whether or not Among Us 2 is in development. The game's official website has been updated with a teaser image that has led many to believe that a sequel is in the works.
Among Us is a psychological thriller game that was released in 2014. The game follows the story of six people who are trapped in an elevator with a killer. The sequel has the potential to be even more suspenseful, given that it would take place in a larger, open environment.
There has been no official announcement from the developers as to whether or not Among Us 2 is in development, but the teaser image on the game's website is certainly intriguing. We will have to wait and see if any further news is released in the near future.
What time is Among Us release on Xbox?
Among Us is set to release on Xbox on August 2nd. The game is a cooperative multiplayer thriller in which players must work together to solve a mystery. Among Us is available for pre-order on the Xbox store.
Posted in xboxTagged allows players access library, allows players access library games, alpha beta tests final, alpha beta tests final version, available platform free play, beta tests final version
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Channel Asia
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Global hardware infrastructure market reaches 'tipping point' towards cloud
Off the back of revenue from IT infrastructure products from 3Q20 rising by 9.4 per cent year-over-year
Sasha Karen (ARN) 13 January, 2021 17:47
Credit: Dreamstime
IT infrastructure has reached a tipping point, with global spending on cloud environments expected to account for a greater share of spending than non-cloud environments.
This is according to research firm IDC's Worldwide Quarterly Cloud IT Infrastructure Tracker, which claimed that revenue from sales of IT infrastructure products — servers, enterprise storage, and Ethernet switches — for cloud environments rose by 9.4 per cent during the third quarter of 2020.
Meanwhile, investment in traditional non-cloud IT infrastructure was down by 8.3 per cent during the same period.
In fact, the research firm said current trends indicate that the hardware infrastructure market has reached a "tipping point", with cloud environments anticipated to continue to account for an increasingly greater share of overall spending.
IDC claimed the growth showed just how important the role of IT infrastructure was during the disruption caused by the coronavirus pandemic.
"Across the world, there were massive shifts to online tools in all aspects of human life, including collaboration, virtual business events, entertainment, shopping, telemedicine, and education," the research firm noted. "Cloud environments, and particularly public cloud, were a key enabler of this shift."
Dell Technologies was the top vendor in the quarter in terms of total revenue and market share, which was US$2.7 billion and 15 per cent, respectively. Meanwhile, Huawei recorded the strongest growth at 44.4 per cent, year-on-year, to US$910 million.
Of the top vendors, Cisco was the only one to record a loss in revenue, declining 6 per cent, to US$1 billion.
Read more Global PC demand surges to highest level in a decade
Spending on public cloud infrastructure increased in the quarter by 13.1 per cent, year-over-year, to US$13.3 billion. This was surpassed by non-cloud infrastructure spending, at US$13.7 billion.
While public cloud spending lost the lead it had on non-cloud spending from the previous quarter, which the firm claimed was for the first time ever, IDC expects public cloud spending to surpass it again in the near future.
Meanwhile, spending on private cloud infrastructure rose by 0.6 per cent, year-over-year, for the period, to US$5 billion. This was mostly driven by on-premises private clouds, which account for 63.2 per cent of the total figure.
As a result of the growth, IDC increased its forecast for cloud IT infrastructure spending for 2020 and is now expecting growth in the market segment of 11.1 per cent, year-over-year, to US$74.1 billion. Additionally, public cloud infrastructure is forecast to grow by 16.7 per cent, year-over-year, to US$52.7 billion.
Read more New Cisco regional leader as Dave West replaces retiring Miyuki Suzuki
Not so fortunate are the forecasts for private cloud infrastructure, which is expected to decline by 0.5 per cent for the year, to US$21.3 billion, and non-cloud infrastructure, now forecast to drop by 11.4 per cent, to US$60.2 billion.
At the component level, compute platforms are anticipated to hold onto their market dominance within deployed environments, with estimated growth of 2.3 per cent to US $36.4 billion. This is then followed by storage platforms' expected growth of 27.4 per cent, to US$29.2 billion, and then Ethernet switches' forecast growth of 4 per cent, to US$8.5 billion.
Looking past 2020, IDC anticipates a five-year compound annual growth rate (CAGR) for cloud IT infrastructure of 10.6 per cent, hitting US$110.5 billion in 2024 to consist of 64 per cent of total IT infrastructure spend.
Meanwhile, spending on non-cloud IT infrastructure is forecast to see a rebound after 2020, but ultimately will decline at an overall CAGR of 1.7 per cent.
Read more Leading Edge DC inks Cisco infrastructure deal
Read more: Cisco coughs up another $1.9B to buy Acacia
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The Devil You Know
A deadly secret changes a woman's life forever
A classic novel, turbulent and emotional, from Sunday Times bestselling writer Josephine Cox, 'hailed quite rightly as a gifted writer in the tradition of Catherine Cookson' Manchester Evening News. The Devil You Know is perfect for fans of Lesley Pearse and Rosie Goodwin.
Sonny Fareham's lover - and also her boss - is the charismatic Tony Bridgeman, a successful and ruthless man who usually gets what he wants. But for Sonny, the affair that has promised a future of hope and happiness must end in desperate fear. Late one evening, Sonny overhears a private conversation between Tony Bridgeman and his wife. Only then does she realise she is in great danger.
Pregnant and afraid, Sonny flees her home to make a new life in the north of England, where she meets a gregarious and motherly new friend, Ellie Kenny. When the mysterious and handsome David Langham seems drawn to her, Sonny almost dares to believe that she could be happy again. But never far away is the one person who wants to destroy everything that she now holds dear...


Take an extended trip on a new cruiser from South Austin Marine! Offering the essentials of home, these boats let you stay out on the water longer. Featuring galleys, sleeping berths, and heads, these cruisers let you take the trips you've dreamed of. Stop into our Austin, TX location and see the cruiser we have for you!


ASUS Zenfone 2 Laser 6 launched with 6-inch fHD display, octa-core processor, 3GB of RAM, 32GB internal storage, 13MP/5MP camera and 3,mAh battery at Rs.17,999/-.
ASUS Zenfone 2 Laser 6 launched to day at Rs.17,999. The device will be available on Flipkart, Amazon and snapdeal starting from second week of December, the smartphone will available in Red, Silver and Gold variant. The ASUS ZE601KL is another new smartphone in ZenFone 2 range of devices in India.
The ASUS ZenFone 2 Laser 6 features with 13-megapixel primary camera with f/2.0 aperture, a 5-element autofocus lens, Laser autofocus and a dual-tone LED flash. For selfies, the handset is equipped with a 5-megapixel front-facing camera that has f/2.0 aperture, 85-degree wide-angle lens, selfie panorama mode, and more. The handset also gets a oleo-phobic anti-fingerprint coating. And backed by 3,000mAh battery.
13MP primery camera,f/2.0aperture,5ielements lens with dual tone LED flash.
5MP front facing camera wit f/2.0 aperture and 85-degree wide angle lens.


Home > Community > Featured and Popular > Product Reviews > To SNOO or not to SNOO?
To SNOO or not to SNOO?
Anyone here used the SNOO? thoughts?
Just ordered it for my baby boy due in March! They are $400 off right now!
You can rent them now FYI. I absolutely recommend. He just outgrew, I miss so much!
Saw it is available to rent. Any first time mom's that swear by it.
me and literally everyone in my office who used it (at least 4 other FTM).
I have a 4 month old. Can I start using it this late?
Has anyone successfully weaned from the snoo without having to re-sleep train your baby? I'm skeptical that the wean setting will really help all that much.
yes I did it. We used wean feature for 2 weeks first. Then moved to crib. Was only issue for 2 nights. The first night we stupidly picked him up each time he cried (since we never had done it before). The second night we let him cry for the 12 minutes, and my husband checked on him. Then he cried 8 more minutes, then slept through.
Slept through night ever since (past 2 months). Good luck!
also, we used the iTunes version of the sound from the Snoo. Repeat the last song. We did this for naps in his crib first few weeks before switching to normal sound machine.
Search in iTunes for happiest baby. Picture above!
Snoo questions: did you guys start using it as soon as you got home from the hospital? How do you know if the baby is hungry since it's supposed to calm them? They just don't calm down? Or you just feed them after a few hours passed if they wake? Also, how was it transitioning from snoo to crib? At what age did you do this?
how do you use the wean feature?
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