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shep doeleman wife
Subscribe to our preview newsletter. Love in lockdown: The couples who split up. Sheperd S. Doeleman, genannt Shep Doeleman (* 1967 in Wilsele, Belgien), ist ein US-amerikanischer Radioastronom. She spearheaded a testing process whereby multiple algorithms with "different assumptions built into them" attempted to recover a photo from the data. Shep Doeleman. Tonio Andrade '92 and Shep Doeleman '86 were named John Simon Guggenheim Memorial Foundation Fellows this spring, joining ranks with dozens of Reed alumni who have been recognized during their careers for their exceptional capacity for productive scholarship or creative ability in the arts. He led the international team of researchers that produced the first directly observed image of a black hole. He now leads an international collaborative project called the Event Horizon Telescope (EHT) whose goal is to image the event horizon of a black hole, the boundary where gravity is so strong that even light cannot escape. By Leah Crane Shep Doeleman led the team that took the first picture of a black holeStephanie Mitchell—Harvard University In April, the world saw the first ever image of a black hole. Follow this link to view the Event Horizon Telescope website. Follow this link to view the Event Horizon Telescope website. In the beginning he lived and worked near Haastrecht in the Netherlands but in … Plunging Into The Physics Of The First Black Hole Image. Take the plunge down past Science Friday coverage. His group at MIT has pioneered development of instrumentation that enables VLBI to achieve the greatest resolving power possible from the surface of the Earth. Shep Doeleman on the Breakthrough Prize-winning black hole photo. shep doeleman: So, right now, we're in the holiest of holies, the central reference room for all of ALMA. 3vor10 Alles was fliegt Amerikanische Begegnungen Andererseits Arte-Fakten Beauty full Science Chemisch gesehen Columbus Gastblog Darwinjahr Das Labortagebuch Deutsches Museum Diax's Rake Die andere Bildung Durchschaut E-Mobility Echolot Ein bisschen dunkel Epi goes Gender Flug und Zeit For Women in Science Geo? Archivierte Blogs. Wife only appears in the thumbnail for this video. So my wife was finally convinced that what I was doing was worth it a little bit," joked Shep Doeleman, the project leader and an astronomer at the Harvard-Smithsonian Center for Astrophysics. Doeleman studied at the Academie van Beeldende Kunsten en Technische Wetenschappen in Rotterdam in 1877. Southern Charm's Shep Rose may not be the most charming wedding guest. The black hole, which is "unseeable" to the naked eye, measures 40 billion km across, or three million times the size of the Earth, It was scanned over a period of 10 days in the Messier 87 galaxy, It is "larger than the size of our entire Solar System", Prof Heino Falcke, of Radboud University in the Netherlands, who proposed the experiment, told the BBC. What does UK vaccine approval mean for US? In the hours after the photo's momentous release, Dr Bouman became an international sensation, with her name trending on Twitter. Heureka Hinterm Mond gleich links Historikertag … So my wife was finally convinced that what I was doing was worth it a little bit," joked the 52-year-old father of two, who is an astronomer at the Harvard-Smithsonian Center for Astrophysics. Sheperd "Shep" S. Doeleman (born 1967) is an American astrophysicist. "3 years ago MIT grad student Katie Bouman led the creation of a new algorithm to produce the first-ever image of a black hole," MIT's Computer Science & Artificial Intelligence Lab wrote. "We have seen what we thought was unseeable," said Shep Doeleman, an astronomer at the Harvard-Smithsonian Center for Astrophysics, and director of the effort to capture the image, during a Wednesday news conference in Washington, D.C. The black hole image, captured by the Event Horizon Telescope (EHT) - a network of eight linked telescopes - was rendered by Dr Bouman's algorithm. Choose an adventure below and discover your next favorite movie or TV show. With an appreciation for the challenges and rewards of instrumental work in difficult circumstances, he pursued his doctorate in astrophysics at the Massachusetts Institute of Technology (MIT). "We got really lucky with the weather... We got lucky in so many ways.". ... "It's truly remarkable, it's almost humbling in a certain way," project director Shep Doeleman of the Harvard-Smithsonian Institute for … "We have seen what we thought was unseeable," said Shep Doeleman, director of the Event Horizon Telescope. Bruce Willis. ", Left: MIT computer scientist Katie Bouman w/stacks of hard drives of black hole image data. Die Kollaboration gab im April 2019 die erstmalige Aufnahme eines schwarzen Lochs bekannt. 02138 (617) 496-7762 Email: sdoeleman@cfa.harvard.edu Web site: https://projects.iq.harvard.edu/sdoeleman EHT Web site: www.eventhorizontelescope.org Education 1986 BA in Physics, Reed College, Portland, OR. EHT Director Shep Doeleman is one of the scientists being recognized for capturing the first-ever image of a black hole. Juul founders Adam Bowen and James Monsees are two of the most influential people of 2019. "It came together because of lots of different people from many different backgrounds.". "When we saw it for the first time, we were all in disbelief. He recently staged a global experiment using these new systems that successfully measured the size of the supermassive black hole at the center of the Milky Way Galaxy. tvtv.de zeigt Ihnen alle Ausstrahlungsdaten der nächsten 19 Tage. VideoLove in lockdown: The couples who split up, Why Trump keeps outperforming the polls. Find out what's happening on Science Friday…on Thursday. Dr Bouman's method of processing this raw data was said to be instrumental in the creation of the striking image. John Simon Guggenheim Memorial Foundation. Image of 'last photon orbit' opens new doors to research on the cosmos. Shep Doeleman: Imaging Black Holes with The Event Horizon Telescope July 15, 2019. im TV : Filme : Das könnte Sie auch interessieren. The results of the algorithms were then analysed by four separate teams to build confidence in the veracity of their findings. Put simply, Dr Bouman and others developed a series of algorithms that converted telescopic data into the historic photo shared by the world's media. One of the most mysterious objects in the universe is the black hole, a region of … In mathematics and computer science, an algorithm is a process or set of rules used to solve problems. Event Horizon Telescope Reveals That Black Holes Are Magnet-Powered The massive Event Horizon Telescope has shed light on how black holes function. look, but how they act on the cosmic stage," Shep Doeleman, the project's director, told AFP in an interview. It was quite spectacular,", How to See a Black Hole: The Universe's Greatest Mystery. It looks like we don't have any Biography for Shep Doeleman yet.. Be the first to contribute! Shep Doeleman, Self: Horizon. Seine Eltern sind die US-Amerikaner Allen Nackeman und Lane Koniak. Ellen Pompeo is pretty chuffed with Sandra Oh's nod (Picture: Rex) Ellen Pompeo has praised Sandra Oh after she was listed on Time's 100 Most Influential People, saying it's 'about time'. By Peter Reuell Harvard Staff Writer. The BBC is not responsible for the content of external sites. Dokumentation, Report • 111 Min. And these are where all the signals that are sent to all the antennas originate. Rose has admitted that he may have not been the best guest at Vanderpump Rules' Jax Taylor and Brittany Cartwright's wedding. ZDFinfo Doku - Giganten des Weltalls - Schwarze Löcher. Mark Zuckerberg dashed across the red carpet so fast, his wife, ... Shep Doeleman of the Harvard-Smithsonian Center for Astrophysics won the prize … HEAD Awards Rossi Prize to EHT's Shep Doeleman This post is adapted from a HEAD press release: The top prize in high-energy astrophysics has been awarded to Sheperd S. Doeleman of the Center for Astrophysics | Harvard & Smithsonian and the Event Horizon Telescope team for the landmark image and analysis of the first "shadow" of a black hole. 34:15. With exclusive access to the team, journalist Seth Fletcher spent five years following Shep and an extraordinary cast of characters as they assembled the Event Horizon Telescope, a virtual … Copyright © 2020 Shep Doeleman, PhD. Doeleman was born on 5 March 1848 in Rotterdam, Netherlands.He married Josina Christina Cornelia Wierikx on 29 October 1874 in Rotterdam. Julia Brendler. This episode of the Physics World Weekly podcast features an exclusive interview with Shep Doeleman of the Harvard–Smithsonian Center for Astrophysics, who is founding director of the Event Horizon Telescope (EHT). from Reed College in 1986, and left soon after for a year in Antarctica where he conducted multiple space-science experiments at McMurdo Station on the Ross Ice Shelf. The 2020 Nobel season continues Tuesday with the physics prize, with astrophysicists Shep Doeleman of the US and Germany's Heino Falcke seen as possible winners for work that led to the first directly observed image of a black hole in April 2019. His research employs the technique of Very Long Baseline Interferometry (VLBI), in which widely separated radio dishes are combined to form an Earth-sized virtual telescope. Dr Bouman was also hailed by MIT and the Smithsonian on social media. Dec 03, 2015 04:01 PM EST Share. But Dr Bouman, now an assistant professor of computing and mathematical sciences at the California Institute of Technology, insisted the team that helped her deserves equal credit. ... Facebook cofounder Mark Zuckerberg and his wife… Shep Doeleman is director of the Event Horizon Telescope Project and an a strophysicist at the Harvard-Smithsonian Center for Astrophysics in Cambridge, Massachusetts. "When we first measured the size of M87 in 2009, we couldn't have foreseen that it would give us the first glimpse of black hole dynamics. But Shep Doeleman and a global coalition of scientists are on the cusp of doing just that. Shep Doeleman. Sheperd Doeleman. Event Horizon Telescope's Shep Doeleman explains how to image a black hole. He has used this technique to study the atmospheres of dying stars, as well as stars that are just being born. The team behind the first ever image of a black hole has won the prestigious $3m Breakthrough Prize. .css-14iz86j-BoldText{font-weight:bold;}A 29-year-old computer scientist has earned plaudits worldwide for helping develop the algorithm that created the first-ever image of a black hole. When it came to girlfriends, Shep Rose was a "playboy". Probe as lottery comes up 5, 6, 7, 8, 9 and 10. Looking for something to watch? Video, South Africa's lottery probed as 5, 6, 7, 8, 9 and 10 drawn and 20 win, China's Chang'e-5 Moon mission returns colour pictures, Trump inciting violence, warns Georgia election official, Baby girl born from record-setting 27-year-old embryo, Covid-19: Pfizer/BioNTech vaccine judged safe for use in UK, Pat Patterson, first openly gay professional wrestler, dies aged 79, India responds to Trudeau's 'ill-informed' remarks. "Today, that image was released. More. During the course of the show, Shep also had some flings with another cast member Chelsea Meissner. Shep Doeleman is trying to snap the first photo of a black hole. Back in 2014, the first season of Southern Charm, he had hooked up a few times with the co-star Kathryn Dennis. Shep Doeleman is one of the most influential people of 2019. .css-1hlxxic-PromoLink:link{color:inherit;}.css-1hlxxic-PromoLink:visited{color:#696969;}.css-1hlxxic-PromoLink:link,.css-1hlxxic-PromoLink:visited{-webkit-text-decoration:none;text-decoration:none;}.css-1hlxxic-PromoLink:link:hover,.css-1hlxxic-PromoLink:visited:hover,.css-1hlxxic-PromoLink:link:focus,.css-1hlxxic-PromoLink:visited:focus{color:#B80000;-webkit-text-decoration:underline;text-decoration:underline;}.css-1hlxxic-PromoLink:link::after,.css-1hlxxic-PromoLink:visited::after{content:'';position:absolute;top:0;right:0;bottom:0;left:0;z-index:2;}First ever black hole image released, Dozen black holes found at galactic centre, Pfizer vaccine judged safe for use in UK next week. Love Story: Taylor Swift offers 'sneak peek' of new re-recordings, "When we saw it for the first time, we were all in disbelief. Shep Doeleman is on Facebook. This project addresses several fundamental questions about the Universe: Do event horizons exist? Lesermeinung. Using the technique of Very Long Baseline Interferometry (VLBI), in which widely separated radio dishes are linked together to form an Earth-sized array, our group has … There, she led the project, assisted by a team from MIT's Computer Science and Artificial Intelligence Laboratory, the Harvard-Smithsonian Center for Astrophysics and the MIT Haystack Observatory. He died on 10 May 1913 in Voorburg, Netherlands.. Career. Warming the hearts of all in attendance, Sahrah's grandfather, Billy Gray, sat to eat with the memorial to his late wife of 45 years. "We have seen and taken a picture of a black hole." At the center of a galaxy more than 55 million light-years away, there's a supermassive black hole with the mass of several billion suns. No single telescope is powerful enough to capture the black hole, so a network of eight was set up to so do using a technique called interferometry. Shep Doeleman received his bachelor's degree from Reed College in 1986 and then spent a year in Antarctica conducting space-science experiments at McMurdo Station on the Ross Ice Shelf. 2020 Nobel season opens with medicine prize "The pandemic is a big crisis for mankind, but it illustrates how important science is," Nobel Foundation head Lars Heikensten said. The closest light can get to a black hole without being "eaten," that orbit is the result of photons being flung off from the super-heated material around the black hole. Stephanie Mitchell—Harvard University. Sieg gegen St. Pauli - Osnabrück rückt auf Platz zwei vor. Shepherd Doeleman during a hearing on the 'Event Horizon Telescope: The Black hole seen Round the World' in Washington, DC May 16, 2019. Did government 'mess up' on lockdown end date? It was quite spectacular," she told BBC Radio 5 live. Shep Doeleman. Hear Shep Doeleman describe the Event Horizon Telescope project and research on black hole M87 in a 2012 Science Friday interview. "A once-in-a-lifetime result," exulted Shep Doeleman, director of the Event Horizon Telescope, the international team of scientists who created the image using a network of radio telescopes linked together to form a single, Earth-size observatory. He is also a Harvard Senior Research Fellow and a Project Co-Leader of Harvard's recently established Black Hole Initiative (BHI). Juul has changed smoking, Tom Miller writes. 'One boy stood out to me - he's now my son', 'I wake up wondering if I still have a job', A young man tries to change racist attitudes in the police force, .css-orcmk8-HeadlineContainer{display:-webkit-box;display:-webkit-flex;display:-ms-flexbox;display:flex;-webkit-box-pack:justify;-webkit-justify-content:space-between;-ms-flex-pack:justify;justify-content:space-between;}South Africa's lottery probed as 5, 6, 7, 8, 9 and 10 drawn and 20 win.css-1dedj2h-Rank{-webkit-align-self:center;-ms-flex-item-align:center;align-self:center;color:#B80000;margin-left:3.125rem;}1, China's Chang'e-5 Moon mission returns colour pictures2, Trump inciting violence, warns Georgia election official3, Baby girl born from record-setting 27-year-old embryo4, Covid-19: Pfizer/BioNTech vaccine judged safe for use in UK5, Pat Patterson, first openly gay professional wrestler, dies aged 796, India responds to Trudeau's 'ill-informed' remarks8, Covid vaccine: What does UK vaccine approval mean for US?9, Love Story: Taylor Swift offers 'sneak peek' of new re-recordings10. Oldenburg. Research Interests: My research focuses on studying super massive black holes with sufficient resolution to directly observe the event horizon. Learn more about the Event Horizon Telescope project. Harvard astronomer Sheperd Doeleman and his team of 200 researchers working on the Event Horizon Telescope did even better. I think your plane landed literally two hours ago in Vancouver. Doeleman and colleagues bagged the 2019 Physics World Breakthrough … So, talk us through how do you get from Einstein's equation to a black hole? Dr. Doeleman led the international team of researchers that produced the first directly observed image of a black hole. Logisch! "These early-EHT experiments provide us with a treasure trove of long-term observations that the current EHT, even with its remarkable imaging capability, cannot match," said Shep Doeleman, the founding director of EHT. The UK is the first country to approve the Pfizer vaccine - with 800,000 doses due to arrive soon. Leben. So my wife was finally convinced that what I was doing was worth it a little bit," joked the 52-year-old father of two, who is an astronomer at the Harvard-Smithsonian Center for Astrophysics. Alle Sendungen mit Shep Doeleman im Fernsehen. Alain Delon. Shep Doeleman, Katie Bouman and other scientists talked black holes with Congress. Shep Doeleman '86, Tonio Andrade '92 Guggenheim Names Two Reedies . Email; All rights reserved. How do black holes affect the evolution of galaxies? (image credit @floragraham)#EHTblackhole #BlackHoleDay #BlackHole pic.twitter.com/Iv5PIc8IYd. Katie Bouman led development of a computer program that made the breakthrough image possible. He is a senior research fellow at the Harvard–Smithsonian Center for Astrophysics and the Founding Director of the Event Horizon Telescope (EHT) project. The effort to capture the image, using telescopes in locations ranging from Antarctica to Chile, involved a team of more than 200 scientists. My institute - the Center for Astrophysics, Harvard & Smithsonian – effectively operate the Event Horizon Telescope project, by Shep Doeleman who's the director of the project. Standing Committee of the Educational Advisory Board. For Dr Bouman, its creation was the realisation of an endeavour previously thought impossible. "Watching in disbelief as the first image I ever made of a black hole was in the process of being reconstructed," she wrote in the caption to the Facebook post. The 2020 Nobel season continues Tuesday with the physics prize, with astrophysicists Shep Doeleman of the US and Germany's Heino Falcke seen as possible winners for work that led to the first directly observed image of a black hole in April 2019.
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An ongoing dialogue on HIV/AIDS, infectious diseases,
all matters medical, and some not so medical.
Really Rapid Review — CROI 2018, Boston
The 25th Conference on Retroviruses and Opportunistic Infections (CROI) just wrapped up in warm, sunny Boston.
Everyone in attendance took advantage of the fine March weather to get some much-needed sun, to feel the sand between their toes, to sip a tropical drink, and to hear the latest in HIV research.
Well, the last part was true — CROI clearly remains our best meeting, the only one that brings together so much high quality research from so many disciplines. Clinical, basic, and behavioral researchers all have a place here.
And though the meeting was bookended by a pair of Nor'easters — the one at the start was a whopper, I thought my dog Louie would blow away in the wind — the weather during most of the conference was actually not bad at all.
On to some highlights, a Really Rapid Review®, with apologies ahead of time for the poor organization. As always, feel free to write in the comments section any important studies I might have missed.
One-month of daily rifapentine/INH prevented TB as well as 9 months of daily INH [37LB]. First place in this RRR® goes to a TB prevention study — this is also a conference on opportunistic infections, remember? This important randomized clinical trial has the potential to change clinical practice, as clearly a one-month preventive strategy is far easier than a 9-month one. One big question — can we extrapolate to HIV negative people?
5 of 11 monkeys treated with both a TLR7 agonist plus a broadly neutralizing antibody did not rebound after stopping ART [73LB]. Not only that, cells from these monkeys (lymph node and PBMCs) did not transmit SHIV to other monkeys in an "adoptive transfer" demonstration of cure (or the closest thing we have to a proof of cure). Very exciting results, with the caveats being that these monkeys were treated with ART within 1-2 weeks of acquiring SHIV, this is SHIV (not HIV), and these are monkeys (not humans).
No increase in IRIS when raltegravir added to a standard regimen of TDF/FTC/EFV [23]. Data are from the REALITY randomized trial in advanced HIV disease conducted in Africa, and contrast with information from observational studies.
Twice daily dolutegravir plus two NRTIs is comparable to TDF/FTC EFV in TB/HIV coinfection [33]. The culprit in drug interactions for all these TB studies is rifampin, which voraciously eats many other drugs alive (that is, induces their metabolism). But doubling the dose of dolutegravir here seemed to do the trick. Note again — no increased risk of IRIS with DTG vs EFV, despite the faster virologic suppression.
TAF/FTC [28LB] likely can be safely administered with rifampin, but bictegravir can't [34]. More on this theme — in the first study, while rifampin lowered plasma levels, intracellular concentrations of tenofovir diphosphate were higher than with standard dose TDF. Doubling the dose of bictegravir did not overcome the induction of the drug's metabolism.
Darunavir/ritonavir plus 3TC is non-inferior to darunavir/ritonavir plus TDF/FTC [489]. Further follow-up of the ANDES study, done in Argentina — think GARDEL, only with DRV/r. Only one patient developed resistance (M184V in triple-therapy arm), and there was no difference in response between high- and low- viral load strata. Study sample size is relatively small (n=145) due to funding limitations.
For patients starting therapy with HIV RNA > 100,000 and/or CD4 < 200, INSTI- and EFV-based regimens have the lowest risk of treatment failure[493]. Since the risk of dolutegravir resistance in treatment-naive patients is so low, DTG plus TAF/FTC has been our go-to regimen in these difficult to treat patients, who are underrepresented in clinical trials.
Switching to BIC/FTC/TAF was non-inferior to continued DTG/ABC/3TC [22]. Remarkably few differences after the switch — same renal, bone, lipid outcomes. In clinical practice, this change will lead to a smaller tablet size and avoid ABC-related cardiovascular risk concerns, but otherwise won't change much. Speaking of …
A series of studies provided further evidence for the association between abacavir use and cardiovascular risk. On the 10-year anniversary of the first report of this association, a bunch of studies might put an end to this "controversy" — these included mechanistic studies involving platelet reactivity [80, 673], platelets and leukocytes [674], an association with pre-clinical CAD on CT angiography [670], and the predicted clinical impact of stopping abacavir on cardiovascular risk [692]. NA-ACCORD study on this issue also just published.
Optimal management of 3rd-line ART in resource limited settings includes the use of darunavir/r and raltegravir, sometimes etravirine [30LB]. We can add this study to the numerous others that show that in treatment failure studies, the patients with the least resistance do the worst — it's a marker for poor adherence. It will be important to document how treatment failures evolve with the widespread implementation of DTG/TDF/FTC, a regimen with a much higher resistance barrier than those with NNRTIs.
Patients with primary HIV infection in France had remarkably high levels of transmitted integrase resistance [529]. 7.4%, 5.6%, and 5.3% in 2014, 2015, 2016, respectively. I wonder what fraction are clinically relevant mutations vs. polymorphisms. On this same topic …
One patient in the treatment-naive studies of BIC/FTC/TAF had transmitted resistance to dolutegravir [532]. I believe this is the first time such high-level integrase resistance has been found in a treatment-naive patient. Since baseline integrase genotyping was not required for study entry, it was picked up retrospectively. The patient was randomized to BIC/FTC/TAF, and achieved virologic suppression.
Certain patients with a history of lamivudine resistance can maintain virologic suppression on a two-drug regimen of lamivudine plus a PI or integrase inhibitor [498]. These M184V patients did, however, have more virologic "blipping", suggesting that HIV control was less robust than with triple therapy. It's also an observational study, not a randomized trial, and I can't imagine choosing to use a two-drug 3TC-containing regimen in someone who is known already to have resistance.
Women switching to BIC/FTC/TAF tolerated the regimen well and maintained virologic suppression [500]. Most had been receiving EVG-containing regimens previously. Since the licensing studies of this regimen had so few female participants, this trial of over 400 women is important if only to show that the treatment is effective in women too.
San Francisco has been making remarkable progress in starting ART as soon as possible in newly diagnosed patients [93]. From 2013 to 2016, the median time from first care to initiating therapy decreased from 27 days to 1. Not surprisingly, the time to viral load < 200 also dramatically dropped, from 134 days to 61 days. A decrease in time to start ART was seen in all demographic groups, including traditionally vulnerable populations (racial and ethnic minorities, homeless).
In a randomized strategy study, same day ART initiation again proved better than standard of care in patient engagement, virologic suppression [94]. Study was conducted in Lesotho, and the novel aspect is that it was also done after home HIV testing. Paper also published in JAMA.
Sertraline does not improve outcomes in cryptococcal meningitis [36]. This commonly used antidepressant has in vitro antifungal activity, but didn't do anything here, prompting early discontinuation of the study for futility. It was certainly worth trying — we definitely need strategies to improve the outcomes with this challenging disease!
Discontinuation of DTG due to CNS side effects is not associated with prior psychiatric diagnoses or plasma levels [424]. The discontinuation rate for DTG overall was 6%, and female sex and older age were risk factors. The lack of association with plasma levels differs from a previous study done in Japan.
Patients surveyed about their preference for novel dosing strategies for ART chose "a single pill taken once a week" as preferred [503]. The other options were "two shots given in the clinic every other month" and "two small plastic implants in the forearm every 6 months."
Treatment of HIV controllers with TDF/FTC/RPV reduces T-cell activation and markers of immune exhaustion [229]. (Disclosure: co-investigator.) Plasma HIV RNA also further declined, and treatment was associated with a modest improvement in quality of life. No effect on absolute CD4 cell counts or HIV DNA.
Only 11% of MSM with acute HCV clear the virus spontaneously [129]. If there is < 2 log drop in HCV RNA by week 4, then clearance is extremely unlikely. The data suggest treatment should be offered at that earlier time point (week 4), for the benefit of both the patient and to prevent further ongoing transmission.
In coinfected patients, FTC/TAF (as part of the BIC/FTC/TAF regimen) shows good activity vs hepatitis B [618]. In this secondary analysis of prospective clinical trials, one patient randomized to a non-TAF regimen acquired hepatitis B.
New HIV infections in Australia have dropped dramatically in association with widespread use of PrEP [88]. The bulk of their HIV epidemic is in MSM, making the target for HIV prevention clear. Plus, one Australian clinician told me that around 95% of those in care are virologically suppressed, which beats the typical US-clinic suppression rate of 85% or so.
Very low doses of MK-8591 protect rhesus macaques against SHIV infection [89LB]. Results suggest this drug might be suitable for less frequent dosing as a PrEP strategy.
Crystal methamphetamine is bad for your telomeres [760]. In a cross sectional study comparing HIV infected people who do and do not use crystal meth, along with HIV negative controls, those who were HIV infected with meth use had telomere "T/S ratios" consistent with 20 years of accelerated aging. This rings true from clinical practice! What a terrible drug.
The dates of CROI are no longer a tightly kept secret (hooray!), so we already know that next year's meeting will be in Seattle, March 4-7, 2019.
As for here in Boston, we're getting ready for our next big storm.
So what did I miss?
Categories: Health Care, HIV, Infectious Diseases, Research
Tags: CROI, Really Rapid Review
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5 Responses to "Really Rapid Review — CROI 2018, Boston"
Philip Lederer says:
Cost of Rifapentine remains an issue but BRIEF-TB/A5279 is an exciting study.
Nicolás Merchante says:
Thanks for (as always) wonderful review. In spite of my conflict of interest (I'm the 1st author), let me suggest abstract 644. US Surveillance for hepatocellular carcinoma often fails and did not translate into earlier diagnosis in HIV+ patients from the @GEHEP_ 002 cohort. Other options needed!
Santiago says:
There was a big controversy about a cellular marker for HIV reservoir. It started with a Nature paper by Descours B et al in 2017 showing CD32+ cells harbored replication-competent virus (the group had shown their results at CROI previously). However in the last session of CROI 2018 there were 4 abstracts showing quite the opposite. A group (abstract 391 by Louise Hogan et al from San Francisco) showed that CD30 could be a better marker. They even tried an anti-CD30 (brentuximab) showing a remarkable effect ex-vivo. They discussed that CD32 seems more a marker of activation related to virus replication that a marker of reservoir.
I think the reservoir is sometimes sneering at us…
Gary Spinner says:
Love seeing your highlights and as an attendee of CROI, always fascinating to see the take-aways from others and how some differ from my own.
I thought the Borducchi study on PG 121 and GS 9620 as a potential cure in monkeys was really exciting. I did not see the part in either the abstract or during the presentation where the adoptive transfer of lymph node cells were transferred to other macaques, and wonder where that part was presented. Thanks so much.
Les Linares-Hengen says:
Thanks for the update! Always appreciated!
Paul E. Sax, MD
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Whitney Ellis Kitchen design ideas, 2018-09-03 01:49:14. I would recommend reviewing the NKBA (National Kitchen & Bath Association) guidelines. They were developed to maximize the functionally and safety in the kitchen. These kitchen guidelines provide recommendations for dishwasher placement, proper distances between doorscabinets, countertop areas, etc. These are a great help in ensuring you have enough clearancespace where needed.
Angelina Scott Kitchen design ideas, 2018-07-24 16:21:09. - Kitchens with an Island - Islands are very popular and provide a great, central work space.
Sofia Hensley Kitchen design ideas, 2018-07-30 16:01:38. Home owners can apply excellent interior design ideas to their kitchens. Kitchens can be given a more retro or a completely utopian design, whichever suits the owner's personality and preferences. Every home owner wants their kitchen to look like the one they see in the interior design magazines and templates. That dream is not difficult to achieve. A home owner can even have a kitchen that looks better than pictured demos with careful planning.


text:
Turkish Journal of Geriatrics	2014 , Vol 17, Issue 4
Turkish Abstract
INVESTIGATION OF THE EFFECTS OF ANESTHESIA TECHNIQUES ON INTENSIVE CARE ADMISSION AND POSTOPERATIVE MORTALITY IN ELDERLY PATIENTS UNDERGOING BILATERAL KNEE REPLACEMENT SURGERY
Elif DOĞAN BAKI1, Özal ÖZCAN2, Mehmet Ersegün DEMİRBOĞAN1, Serdar KOKULU1, Hanife UZEL3, Yüksel ELA1, Remziye Gül SIVACI1
1Afyon Kocatepe University, Anesthesiology and Reanimation AFYON
2Afyon Kocatepe University, Orthopedics and Traumatology AFYON
3Afyon Kocatepe University, Public Health AFYON Introduction: The purpose of this study is to investigate the effects of anesthesia techniques on intensive care admission, postoperative complications and mortality in elderly patients undergoing elective bilateral knee replacement surgery.
Materials and Methods: A retrospective file review in the Anesthesiology and Reanimation Department of Afyon Kocatepe University between January 2008 and October 2013 was done on patients operated for bilateral knee replacement in the same sessions by the same surgeon
Results: 108 females and 27 males, a total of 135 patients, were included in this study. 83 patients were operated under general anesthesia while 52 were under regional (epidural+spinal) anesthesia. 123 (91.1%) of patients were admitted to service after operation while 12 (8.9%) of them were admitted to the ICU, 10 (7.4%) of whom were in Group G (general anesthesia) and 2 (1.5%) in Group R (regional anesthesia) (p>0.05). The development rates of complications were significantly higher in Group G (11.1%) than in Group R (0.7%) (p=0.005). Hypertension was the most frequent concomitant disease and acute renal failure was the most frequently observed complication. 15 of 16 patients in whom complications were observed had hypertension. Mortality was 1.48% .
Conclusion: Postoperative complications and intensive care unit admission are more frequently encountered among patients operated for bilateral knee replacement under general anesthesia than with regional anesthesia. Keywords : Aged; anesthesia; Arthroplasty, Replacement, Knee


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Port Gibson
Clairborne County
Vicksburg-Warren School District
Downtown Vicksburg
East family runs home for Chill in the Hills
The weather is cold and the hills are tough. But this did not discourage the East family from participating in the Chill in the Hills ... Read more | Add your comment
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Armed robbery leaves victim with gunshot wound
Teen sought in shooting incident
Warren Central
Porters Chapel
Crandall repeats as Chill in the Hills champ; 12-year-old Eldridge wins women's title
Ryan Crandall plans to get married later this spring. He and his bride can probably take bowls off the gift registry. The 27-year-old from Madison ... Read more | Add your comment
Sports column: Longevity in sports can be inspiring and depressing
Photo Gallery: Chill in the Hills 2021
Who's Hot
Photo Gallery: Vicksburg Cotillion Club presents 45 future leaders
Monday, December 7, 2020 1:27 pm
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Clement named winner of Landy Teller Champion for Culture & the Arts Award
Debra Franco Preparatory School of Dance prepares for 'The Nutcracker'
Extension: Christmas tree demand is pandemic-proof
Vicksburg Orchestral Society
Rebecca Evans Johnson
Floriece Thompson Chambers
Victoria Caldwell Thomas
Vicksburg Orchestral Society's Sunday concert begins new season
By Terri Cowart Frazier
Published 3:50 pm Thursday, November 7, 2019
The Vicksburg Orchestral Society will present its fall concert Sunday to kickoff the 2019-2020 season.
The performance will begin at 4 p.m. at the Church of the Holy Trinity, 900 South St., and the concert is titled "Musical Monuments."
Dr. Darcie Bishop, who is the principal trumpet player for the Mississippi Symphony Orchestra and who teaches trumpet lessons at the Conservatory for the Fine Arts will serve as conductor.
"The repertoire will focus on classical pieces," VOS board member Deborah Felt said, with selections including a Mozart Overture and Haydn's Symphony 100.
Vivaldi's Concerto in A Minor will also be performed and will feature flautist Mary Claire Allison.
Allison, who has performed with the VOS since its inception, is a music teacher at Porter's Chapel Academy and is employed at U.S. Army Engineer Research and Development Center.
Sunday's concert will also pay tribute to the armed forces as Veterans Day approaches, Felt said.
The VOS is comprised of individuals of all ages, abilities and professions and there are no fees or dues to join the group.
"Some of our musicians play with the MSO and teach music," Felt said, while others have excelled in careers other than music.
"The VOS allows them an outlet to follow their hobby," she said.
Felt said there are also VOS members who are just starting out playing a musical instrument.
"These members welcome a chance to play for an audience," Felt said.
The VOS performs three concerts annually and this marks the group's 10th year.
All the concerts are free.
The second concert of the season will be performed on April 5 and the third will be held June 28.
All performances are scheduled at 4 p.m.
About Terri Cowart Frazier
Terri Frazier was born in Cleveland. Shortly afterward, the family moved to Vicksburg. She is a part-time reporter at The Vicksburg Post and is the editor of the Vicksburg Living Magazine, which has been awarded First Place by the Mississippi Press Association. She has also been the recipient of a First Place award in the MPA's Better Newspaper Contest's editorial division for the "Best Feature Story."
Terri graduated from Warren Central High School and Mississippi State University where she received a bachelor's degree in communications with an emphasis in public relations.
Prior to coming to work at The Post a little more than 10 years ago, she did some freelancing at the Jackson Free Press. But for most of her life, she enjoyed being a full-time stay at home mom.
Terri is a member of the Crawford Street United Methodist Church. She is a lifetime member of the Vicksburg Junior Auxiliary and is a past member of the Sampler Antique Club and Town and Country Garden Club. She is married to Dr. Walter Frazier.
"From staying informed with local governmental issues to hearing the stories of its people, a hometown newspaper is vital to a community. I have felt privileged to be part of a dedicated team at The Post throughout my tenure and hope that with theirs and with local support, I will be able to continue to grow and hone in on my skills as I help share the stories in Vicksburg. When asked what I like most about my job, my answer is always 'the people.'
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© 2021, The Vicksburg Post


Tardis-like, Baltic's narrow frontage on noisy Blackfriars Road is a misleading introduction to what lies within. Step inside and you'll discover an 18th-century coach-builder's workshop that has been hollowed out and dressed in white –a barn-sized yet utterly elegant space with soaring ceilings, skylights and concrete floors. The dining room is reached through the bar, where inviting cocktails and icy vodkas may encourage you to linger. The menu roams across the Baltic and beyond, jumping borders and delivering a hotchpotch of culinary refugees from pierogi and pelmeni dumplings, spätzle and blinis with various toppings to gutsy winter-warming plates of pork shank with sauerkraut or lighter options such as red snapper in walnut and pomegranate sauce. There's a generous list of Old World wines, jazz on Sunday evenings and a good-value set menu at £19.50.
Good, friendly service, lively atmosphere, very reasonably priced pre-theatre menu and enjoyable food! The house wine is also good and reasonably priced. I would recommend The Baltic as an excellent pre-theatre option for the Old or Young Vic.
Light and airy and uncluttered, this is a very pleasant place to eat - smart but not too formal. The pre-theatre menu was good value and the portions were very generous, the service was friendly and efficient but not hurried. The restaurant was lively but not too noisy. A popular spot.
Although this is hardly a new opening, I visited with family for the first time on the Saturday of Easter weekend. It was not a busy evening, but there were enough people to make some atmosphere. The service level was excellent. All the staff were knowledgeable and friendly. Help was certainly needed with the huge selection of vodkas. The ones we selected were all excellent, especially the honey vodka which is served hot! Between the four of us we had a good selection of food and it was all excellent. The was a big surprise at the end when the bill arrived and it was significantly less than I expected given the quality and quantity of the food and drink we had consumed. I would definitely recommend this restaurant to anyone wanting a fun dinner with something different from the standard European dining experience.
Visited Saturday lunchtime before heading off to the rugby at Twickenham. Good choice on the menu and noticed that the starter and main course I would have chosen from the a la carte menu were also on the set price menu. Started with Kapusniak, a substantial soup of Sauerkraut, pork and sausage, followed by a main course of lamb stew with pumpkin. My fellow diners chose duck rillettes and chargrilled pork neck with vegetables from the set price menu at £19.50 for two courses or £22.50 for three courses. The price includes a Bloody Mary or a Bellini. A bottle of good Hungarian red at £21.00 and the bill including a cheese board, one glass of port and three coffees was £133 including 12.5% service charge for four people. A really good start for what turned out to be an excellent day with England edging past Ireland at Twickenham. Would definitely come again, maybe in the evening to sample the extensive range of vodka.
Baltic is a loud buzzy vibrant place and probably perfect for pretty much any occasion; from a romantic liaison to a large group (work or family). Unless you're from E.Europe the flavours and sometimes the ingredients won't be familiar. Don't worry, experiment, they all work and you won't be disappointed as the cooking is very skilful. In addition to the excellent menu is an extensive list of vodka's which is also highly recommended.
Wow, from the outside this place looks like a small, unexciting bistro but then you walk through to the restaurant area and it's just stunning, with a beautiful glowing amber light installation. Both the cocktails and sublimely light blinis we shared at the bar were excellent. Skipped starters and went straight to main when my shoulder of lamb was the tenderest I have ever had. We just had a tiny space left for the apple pie with cinnamon ice-cream which was buttery and delicious. Service was attentive but also relaxed and friendly throughout. Really can't fault this place at all – it's well worth the reasonable (for London) prices and it'd definitely going on my favourites list.
I used to love this restaurant when it really represented "baltic" dining. The current menu is very disappointing as it is trying to have a bit of everything which means offering dishes that are more standard British or Turkish than Eastern European. If you stick to the Eastern European dishes, the food is lovely but slightly over-priced for what it is. The cocktails though make up for it somewhat as they are supurb. The number of Polish vodkas is incredible and the martinis made from them are the smoothest I tasted. Please Baltic, let me love you again and change your menu to have truly Baltic only dishes.
By 9.30 on a Saturday, night 5 main courses were unavailable. Between us, our party ordered the unavailable dishes sequentially, such that it was 10.30 before it became crystal clear that zero of 5 of us were going to get what we ordered. By 10.55, we left, having tried only starters ,so my comments on the food pertain to only the overly sweet eel (inedible and sent back) and the dumplings (thank god there were loads of them unceremonially dumped on the plate, as we were starving). Not clear which part of the Baltic region the shish kebab dish represented, but the waiting staff represented part or parts which had clearly only recently emerged into the concept of being basically polite to customers and hence were not yet fully familiar with the concept. Value for money is rated higher than would be anticipated, since although they didn't buy us a drink for having wasted our evening and sent us racing home starving for bacon sandwiches at nearly 11pm, they did forget to charge us for our cocktails and we didn't think it fair on ourselves to remind them.


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Using futures methods to create transformative spaces: visions of a good Anthropocene in southern Africa
Pereira, L. ORCID: 0000-0002-4996-7234, Hichert, T., Hamann, M. , Preiser, R. & Biggs, R.
(2018). Using futures methods to create transformative spaces: visions of a good Anthropocene in southern Africa. Ecology and Society, 23(1), 19. doi: 10.5751/ES-09907-230119
The unique challenges posed by the Anthropocene require creative ways of engaging with the future and bringing about transformative change. Envisioning positive futures is a first step in creating a shared understanding and commitment that enables radical transformations toward sustainability in a world defined by complexity, diversity, and uncertainty. However, to create a transformative space in which truly unknowable futures can be explored, new experimental approaches are needed that go beyond merely extrapolating from the present into archetypal scenarios of the future. Here, we present a process of creative visioning where participatory methods and tools from the field of futures studies were combined in a novel way to create and facilitate a transformative space, with the aim of generating positive narrative visions for southern Africa. We convened a diverse group of participants in a workshop designed to develop radically different scenarios of good Anthropocenes, based on existing "seeds" of the future in the present. These seeds are innovative initiatives, practices, and ideas that are present in the world today, but are not currently widespread or dominant. As a result of a carefully facilitated process that encouraged a multiplicity of perspectives, creative immersion, and grappling with deeply held assumptions, four radical visions for southern Africa were produced. Although these futures are highly innovative and exploratory, they still link back to current real-world initiatives and contexts. The key learning that arose from this experience was the importance of the imagination for transformative thinking, the need to capitalize on diversity to push boundaries, and finally, the importance of creating a space that enables participants to engage with emotions, beliefs, and complexity. This method of engagement with the future has the potential to create transformative spaces that inspire and empower people to act toward positive Anthropocene visions despite the complexity of the sustainability challenge.
Copyright © 2018 by the author(s). Published here under license by The Resilience Alliance. This article is under a Creative Commons Attribution-NonCommercial 4.0 International License. You may share and adapt the work for noncommercial purposes provided the original author and source are credited, you indicate whether any changes were made, and you include a link to the license.
Anthropocene; futures; imagination; scenarios; southern Africa; transformative spaces; transformations
School of Health & Psychological Sciences > Psychology
School of Health & Psychological Sciences > Healthcare Services Research & Management > Food Policy
Text - Published Version
Pereira, L. ORCID: 0000-0002-4996-7234
Hichert, T.
Hamann, M.
Preiser, R.
Biggs, R.
Ecology and Society
The Resilience Alliance
12 December 2017 Accepted


Approaching summer exams during the last year of high school can be a stressful time, believe me!
Trying to squeeze in last minute revision, trying to balance revision and homework. I understand!
It was right in the middle of this stressful nightmare that an organisation called NCS came into my school to gather recruits. At the time, I vaguely knew what the programme was about, as I had heard and seen a few older students have an amazing summer because of it. But that was it!
Phase 1- Residential Trip: We were taken away to a residential centre to have a week of pushing the limits of our comfort zones and team bonding in a series of practical and mental challenges. The week is a time of such excitement and leaves you prepared for the weeks to come as you bond with your teammates. I for example, went away to Shropshire, placed in a dorm room with my new found friends. This type of programme is designed to give the graduates a sense of independence, it's important to recognise that the NCS leaders and assistants are NOT there to act like teachers, they are there to give you guidance in order for you to have the best summer you possibly can. Our activities were also pretty daring, we tried our hand at zip wire, kayaking, wild survival and even a silent disco to finish. I mean that in itself is a pretty awesome week, right?
Phase 3 – Social Action Week: This is the week that you and your teammates will meet with your team leader to plan your Social Action Project, with each person putting in at least 30 hours of their time into the project in order to graduate. You decide on a project that is going to benefit and have an impact on your community in some way and then spend the week gathering ideas, preparing your presentation and contacting local businesses to ask for the involvement or maybe even donations in order for your project to be able to happen.
Phase 4: Social action week…in action! : This is when everything that you've learnt in the past 3 weeks is put to the test. We met with our team to get all our final prep done and it really is 'all hands on deck' during this week! For my Social Action Project, we decided to opt for something that we all felt passionately about and turned that into our main fundraising event – a charity gig in aid of Suffolk based organisation Outreach Youth, an LGBTQ+ community that help hundreds of young people in the local area with struggles they may be facing. They run entirely from donations, so we felt like it was the perfect cause to raise money for.
We got together some local bands, pitched our ideas to the NCS leader and the Mayor of Ipswich who were two people that had the final decision on whether or not, they thought our project was worth investing in…bit like a Dragon's Den interview!
Success – our project was full steam ahead, but of course like with any project, we hit some of bumps in the road. You know what they say, "what doesn't kill you, makes you stronger" and having a team that stuck together and encouraged one another, we ended up with an amazing project with a brilliant turn out!
Our £75 went towards hiring a small community hall for our venue that was accessible to all of the team. We organised smaller fundraising events such as a family fun day, a bake sale and supermarket bag packing for 8 hours in order to fund the rest of the event.
In the end, it was all well worth it, as our gig night went off with a bang! We held a raffle and face painting at the gig and at the end of the event raised a huge total of £400!! How amazing is that?
So, why did I do it? After a stressful year preparing and completing my GCSE's, I wanted to make the most of my summer! The entire programme only cost me £50 and for me, NCS was a once in a lifetime experience; it's left me with so many memories and friends that I'll remember for a lifetime, why would you want to spend a summer staying inside playing Xbox, when you can be learning about yourself, others and giving yourself the opportunity to open so many doors!
To finish and celebrate our hard work, of course there is graduation! My teammates and I, along with the other teams across the country come together for a night of celebration, including pictures, videos and interviews from previous graduates in how NCS has impacted their lives since leaving school.
The beauty of this programme is that you get the opportunity to do it straight after your exams so it helps take away the stress and anxiety you feel awaiting the results. NCS also allows you time to develop skills like working effectively as a team and building your independence and confidence and I believe it is something that workplaces are familiar with and can really stand out on your CV. UCAS even recommend having this on your personal statement, just for extra kudos!
So my advice – GO, have an amazing summer like I did, you'll be thankful you did it. It all starts with a YES!
Next Next post: Education or Vacation?


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When the World is on Fire: How to Cope with Things We Can't Control
Our world is changing fast. Our climate, the job market, politics, racism, #metoo, COVID and its variants, even what life looks like when--or if--we graduate college are all critical issues. And on top of the challenges we share in this uncertain world, our personal struggles can leave us feeling overwhelmed and out of control. So what can we do when it feels like our world is on fire?
Share the Load
We hear all the time that it's good for us to stay connected, but it can be hard to reach out when we're struggling. Making that call to a family member or friend to get together, talk, or even just to say hi until we feel supported can make a huge difference in how we experience the things we're going through. In a study of a California community that experienced multiple wildfires, the group that reached out to social supports reported better mental health outcomes after five months than those who stayed more isolated (Felix & Afifi, 2015).
Go Easy on Yourself
Have you felt guilty that you aren't doing "enough" to make things better? We can all feel that way, whether we're having trouble getting out of bed or are burned out from volunteering every free moment. By focusing attention on our values and what's important to us, we can strengthen our sense of who we are in relation to a problem, calm our bodies and minds, and improve our resilience (Sherman, 2013). For a start, try making a list of 5 things that matter to you to look back on when you feel overwhelmed. Maybe it's building relationships, taking care of our world, making art, or enjoying warm blankets after a tough day. There are no wrong answers.
Find Your Peace
Learning how to live in a world that's often chaotic is increasingly important. How do we find a sense of calm when the world is anything but? For many people, being mindful can create a sense of refuge inside of us instead of looking for it somewhere else. While different methods work for different people, one key piece of every method is noticing what we're feeling without judgement. This has serious benefits: "Mindfulness, by increasing non-judgmental and non-reactive responses to positive and negative emotions, situations, and objects, allows for more balanced and calm reactions, which rapidly reduces the intensity of emotional states" (Juneau et al., 2020).
Making change where we can is important. But to do that, and to have the energy we need in this unpredictable world, we have to shore up our internal resources first. If you need help, the student therapists at the Olson Clinic 319-368-6493 can help you find your strengths.
References;
Felix, E. D., & Afifi, W. (2015). The role of social support on mental health after multiple wildfire disasters. Journal of Community Psychology, 43(2), 156–170. https://doi.org/10.1002/jcop.21671
Juneau, C., Shankland, R., & Dambrun, M. (2020). Trait and state equanimity: The effect of mindfulness-based meditation practice. Mindfulness, 11(7), 1802–1812. https://doi.org/10.1007/s12671-020-01397-4
Sherman, D. K. (2013). Self-affirmation: Understanding the effects. Social and Personality Psychology Compass, 7(11), 834–845. https://doi.org/10.1111/spc3.12072
Picture by Samer Daboul from Pixels


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State lawmakers get update on CWD in MN
By Minnesota News Network|2020-02-19T06:22:24-06:00February 19th, 2020|
State lawmakers got an update today on Chronic Wasting Disease (CWD) in the state's deer population. C-W-D is an always-fatal neurological disease that affects deer, elk and moose and so far, in Minnesota, it's been most prevalent in a southeastern portion of the state.
"Although it's disappointing that we continue to find positive deer, this disease is still rare in our state and its footprint is small, so we have an aggressive approach, so we, however, try to keep it that way, and we have an adaptive approach as well."
Dr. Barbara Keller with the DNR says 27 deer total tested positive during testing this fall. CWD was first detected in Minnesota in 2002. To date, 79 wild deer have been confirmed positive for C-W-D in Minnesota.


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Patriots sign top draft pick, DL Malcom Brown of Texas
FOXBOROUGH, Mass. (AP) The New England Patriots have signed their first-round draft pick, defensive lineman Malcom Brown from Texas.
The Patriots chose Brown with the 32nd pick after his three-year college career in which he had 8 1/2 sacks, two fumble recoveries and 165 tackles in 39 games, 26 of them starts.
It was the second straight year in which the Patriots took a defensive lineman in the first round. Last year, they chose Dominique Easley from Florida. He played in a backup role and finished the season on injured reserve.
The departure of Vince Wilfork to Houston as a free agent could create a greater opportunity for Brown.
The Patriots also released tight end Fred Davis, a second-round pick in 2008 who spent his first six NFL seasons with Washington.
AP NFL websites: www.pro32.ap.org and www.twitter.com/AP-NFL
dominique easley
malcom brown


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Manchester mayoral candidates campaign in the Queen City
The two met with voters Saturday
Updated: 10:38 PM EDT Oct 28, 2017
Suzanne Roantree
WEBVTT WMUR'S SUZANNE ROANTREE CAUGHTUP WITH THEM.SUZANNE: MAYOR TED GATSAS ANDHIS OPPONENT IN THE UPCOMINGELECTION JOYCE CRAIG WERESHAKING HANDS ACROSS THE CITYUSING TODAY TO SPREAD THEIRMESSAGES TO AS MANY PEOPLE ASPOSSIBLE.IN 2009, DEMOCRAT JOYCE CRAIGWON A SEAT ON THE MANCHESTERBOARD OF MAYOR AND ALDERMEN.THIS IS THE SECOND TIME THATCRAIG IS CHALLENGING REPUBLICANTED GATSAS FOR THE JOB OF MAYOR.AFTER A RECOUNT IN 2015, SHELOST TO HIM IN 2015 BY 64 VOTES.>> WE NEED A LEADER IN OUR CITYTHAT UNDERSTANDS THAT PUBLICSCHOOLS ARE SO IMPORTANT TO OURCOMMUNITY AND THE FUTURE THAT WEHAVE.AND SOMEONE WHO CARES ABOUTLIFTING UP IN OUR CITY TO MAKETHINGS BETTER.SUZANNE: CRAIG SAYS WHEN ITCOMES TO THE OPIOID CRISIS,MANCHESTER NEEDS A LEADER WHOTAKES A GRASSROOTS APPROACH.>> WE NEED TO BRING THETREATMENT COMMUNITY TOGETHER ANDDO A BETTER JOB WITH THAT.WE NEED TO HOLD LANDLORDSRESPONSIBLE THAT HAVEDELAPITATED BUILDINGS IN OURCITY.WE CAN'T JUST ALLOW THIS TO GOON.THE POLICE AND FIRE HAVE BEENVERY SPECIFIC ABOUT WHAT WE NEEDTO DO AND WE NEED A LEADER INMANCHESTER TO LISTEN TO THEIRFEEDBACKS.SUZANNE: TED GATSAS HAS BEENMAYOR OF MANCHESTER FOR THE LASTEIGHT YEARS AND HE SAYS HE TOOHAS HIS EYE ON THE OPIOIDCRISIS.>> NOW THAT THE PRESIDENT CALLEDIT A STATE OF EMERGENCY THAT ITHINK FUNDING IS GOING TOFOLLOW.AND I THINK WE NEED TO PUT EVERYFOOT FORWARD TO END THISABSOLUTE TRAGEDY THAT WE ARELOSING SO MANY YOUNG LIVES WITH.SUZANNE: BUT OUT IN THECOMMUNITY TODAY, HE SAYS THECONVERSATION IS A BIT DIFFERENT.>> TAXES -- THAT'S THE NUMBERONE ISSUE ON EVERYBODY'S MINDSTODAY WHEN WE ARE MEETINGPEOPLE.WE WERE AT BELMONT HALL.THAT WAS THE CONVERSATION WITHAN AWFUL LOT OF PEOPLE ABOUTTHEIR TAXES.SUZANNE: LOCAL ELECTIONS ARE
Election Day for New Hampshire communities is fast approaching. Many candidates, including Manchester's two mayoral candidates, were out shaking hands Saturday. Mayor Ted Gatsas and his opponent in the upcoming election, Joyce Craig, canvassed the city Satruday to spread their messages to as many people as possibleIn 2009, Craig, a Democrat, won a seat on the Manchester Board of Mayor and Aldermen. This is the second time that Craig is challenging Gatsas for the job of mayor. After a recount in 2015 she lost to Gatsas by 64 votes. "We need a leader in our city that understands that public schools are so important to our community and the future that we have, and someone who cares about lifting up in our city to make things better," Craig said.Craig said when it comes to the opioid crisis, Manchester needs a leader who takes a grassroots approach."We need to bring the treatment community together, and do a better job with that. We need to hold landlords responsible that have dilapidated buildings in our city. We can't just allow this to go on. The police and fire have been very specific about what we need to do, and we need a leader in Manchester to listen to their feedbacks," she said.Gatsas has been mayor of Manchester for the last eight years and he says he too has his eye on the opioid crisis"Now that the president has declared it a state of emergency, then I think funding is going to follow, and I think we need to put every foot forward to end this absolute tragedy that we are losing so many young lives with," Gatsas said.Out in the community, he says the conversation is a bit different."Taxes. That's the number one issue on everybody's minds today when we are meeting people. We were at Belmont Hall that was the conversation with an awful lot of people about their taxes," he said.Local elections are on Nov. 7.
MANCHESTER, N.H. —
Election Day for New Hampshire communities is fast approaching.
Many candidates, including Manchester's two mayoral candidates, were out shaking hands Saturday.
Mayor Ted Gatsas and his opponent in the upcoming election, Joyce Craig, canvassed the city Satruday to spread their messages to as many people as possible
In 2009, Craig, a Democrat, won a seat on the Manchester Board of Mayor and Aldermen. This is the second time that Craig is challenging Gatsas for the job of mayor.
After a recount in 2015 she lost to Gatsas by 64 votes.
"We need a leader in our city that understands that public schools are so important to our community and the future that we have, and someone who cares about lifting up in our city to make things better," Craig said.
Craig said when it comes to the opioid crisis, Manchester needs a leader who takes a grassroots approach.
"We need to bring the treatment community together, and do a better job with that. We need to hold landlords responsible that have dilapidated buildings in our city. We can't just allow this to go on. The police and fire have been very specific about what we need to do, and we need a leader in Manchester to listen to their feedbacks," she said.
Gatsas has been mayor of Manchester for the last eight years and he says he too has his eye on the opioid crisis
"Now that the president has declared it a state of emergency, then I think funding is going to follow, and I think we need to put every foot forward to end this absolute tragedy that we are losing so many young lives with," Gatsas said.
Out in the community, he says the conversation is a bit different.
"Taxes. That's the number one issue on everybody's minds today when we are meeting people. We were at Belmont Hall that was the conversation with an awful lot of people about their taxes," he said.
Local elections are on Nov. 7.


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Posted on August 14, 2018 September 17, 2018 by Toddley
On Twitter tonight, one of the trending hashtags was #TheseLyricsChangedMyLife. Being the music fiend that I am, I had to jump into that conversation.
As the night went on, I started thinking about life and how music plays such a vital role in my survival. Music has always been my safe place, and I need it almost as much as I need food and water.
Throughout my life, many music artists have touched or inspired me, whether it be through their heartfelt lyrics, fearless attitude, mind-boggling vocal skills, or their endless drive to fulfill their dreams.
So on this #MusicMonday, I figured why not chat and sip about some of the singers who have most impacted my life. I have a vast array of favorites from Aretha Franklin to P!nk. However, there are three standout artists that have profoundly affected me.
Credit: Global Take
I quoted Janet for the #TheseLyricsChangedMyLife hashtag tonight. I tweeted the line "…cause nothing ventured is nothing gained" from the song "He Doesn't Know I'm Alive" off her 80s hit album Control.
Those words helped me find the courage to ask someone out. I got rejected (🤦♂LOL), but I'm glad I actually found the nerve to go through with it.
That lyric still speaks volumes to me because I often find myself battling fear. Like many people, I sometimes worry about failure and have to remind myself that you never know what will happen unless you try. Therefore, you have to step out of your comfort zone sometimes and take a chance.
Miss Jackson also helped me deal with my sexuality. Her album, The Velvet Rope, with its homophobia-bashing dance number "Free Xone," helped me start to see that there was nothing wrong with me.
That album also showcased themes of being strong and not avoiding the pain in your life. It really hit home and helped me find my own strength as a lost teenager.
Credit: The New Orleans Advocate/Peter Kramer/NBC
Way before American Idol or his daytime talk show, I was a Harry fan. This guy introduced me to jazz music and unofficially taught me how to sing, along with Stevie Wonder.
I still remember the first time I ever heard one of Harry's songs. It was during Christmas time in the early 2000s. I was driving around on my prescription delivery job, listening to whatever station was playing nonstop Xmas songs at the time. His rendition of "Let it Snow" graced the airwaves, and the lush arrangement with its blaring big band horns completely drew me in.
I was captivated even more by the rich tone of his voice. I had never heard anyone sound that good before. The very next day I went to Best Buy and bought his Come By Me album, and I became an official Harry Connick, Jr. fan.
I've sung his songs at talent shows and open mics more times than I can count. I used to be scared to sing loudly, but that all changed after Harry. I pushed out his big note at the end of "Charade" one night at an open mic, and I've been belting ever since.
I even wrote a letter to his fan club back when fan clubs still existed. (Dang, I'm showing my age. Lol). He didn't write me back himself, but whoever ran his fan club sent me a free cd of some Broadway show soundtrack he helped write. I was kinda pissed he didn't write me back personally, but I guess getting a free cd was better than nothing. Lol.
Although we've never met (and probably never will), I can say that I owe some of my music success to Harry. He truly got me excited about singing and helped me begin to discover the capabilities of my voice. I will be eternally grateful for that.
Credit: Celebzz
In the early 2000s, the queens of pop were undoubtedly Britney Spears and Christina Aguilera. Even if you liked them both, you most certainly had a favorite out of the two, and I was Team Christina all the way! Her voice, lyrics, and attitude all gave me life!
No one else in pop music could hold a candle to her vocally in those days, and she inspired me to sharpen my vocal skills. I would actually practice singing to her songs every single night (dropping them down an octave though…lol!).
But her voice wasn't just fun to sing along to; It truly moved me. She was one of the few artists whose voice could make me cry.
She was always so confident and carefree back in the day too. Being a shy guy, her self-assurance inspired me. I could be nervous about something and think about Christina, and I would somehow find the nerve to push through. Not many artists did that for me.
Throughout her career, she has recorded numerous songs about strength and not letting others break you down. Her encouraging lyrics continue to resonate with me, and she will forever be one of my favorite artists of all time.
There are many more singers who have left their mark on my life, but these three are definitely some of the key figures.
Which artists or bands have inspired you the most in your life? I'd love to know. Feel free to share in the comments below.
If you've enjoyed what you read, please be sure to like, share, or comment below. I'd really appreciate it! 🙂
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2 thoughts on "Which music artists have had the greatest impact on your life?"
AV	 August 15, 201810:39 AM	 Reply
As much as I like some artists, I can't say I just sat down and listened to their music to console me, that I recall. However, Mary J Blige, Beyonce's Lemonade album (I can't find my cd) and Amy Winehouse are good picks to listen to when you are thinking of relationships etc.
Toddley	 August 15, 20182:20 PM	 Reply
Yeah. I have sure related to "Hold Up" and "Sorry" before. Lol


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Business Local News
Global footwear manufacturer Skechers steps up presence in Kenya
January 20, 2020 KASS ONLINE
USA footwear manufacturer Skechers has commenced an ambitious plan to claim a share of the lucrative East African market with the launch of two ultra-modern stores in Kenya.
The company says the two stores, located at Sarit Centre and Village market malls, are integral to the global footwear manufacturer's plan to expand its retail, sales and logistic infrastructure to meet the global market's growing demand. A similar investment is lined up for Uganda before close of the year.
Last year, Skechers crossed the 3,000-retail-store milestone following the opening of a superstore in Shenyang, China the company's largest in the world. The brand is present in more than 170 countries through an extensive network of company-owned stores, distributors and joint ventures.
The Kenya franchise is operated by Phirdos Kenya Ltd, the sole distributor of Skechers and Clarks footwear in the country. "Skechers is a brand for the world. The stores that we are opening in Kenya join a network of superstores across the globe designed to showcase the brand's diverse footwear styles and a growing line of apparel and accessories. The Sarit Centre and Village Market stores are a customer experience showcasing an unparalleled product offering outside of the Company's e-commerce solutions and designed with the latest point-of-sale technologies," said Mr. Fat-hi Basheikh, Phirdos Kenya Country Manager.
Speaking during the official opening of the stores, Mr. Basheikh disclosed that Phirdos Kenya will invest more than Kshs 500 million in the next two years in setting up more stores in Nairobi, Mombasa, Kisumu, Nakuru and Eldoret as Skechers angles for the country's growing lifestyle and performance footwear market segment.
"We are seeing many opportunities to grow our retail stores coverage in East Africa and particularly Kenya. We have been trading in the UK, US, Europe and Middle East for over a decade but with a muted presence in Kenya over the last two years. We are now ready to service this market in a big way. We are putting up a state of the art training facility at our regional headquarters in Nairobi to ensure that our staff are trained to international standards," Mr. Basheikh noted.
Currently ranked the third largest athletic-footwear maker in the U.S, Skechers designs, develops and markets a diverse range of lifestyle footwear as well as performance footwear. Its product range comprises of 3,000 styles for men, women and children.
← President Kenyatta launches Kenya's first green bond at London Stock Exchange
Kenyan govt keen on eliminating obstacles to private sector growth, President Kenyatta says →
Kenya to host PKF-I Africa Auditors conference
Emirates SkyCargo supports Kenya's global export
President Kenyatta tells off opposition over tribal incitement; attends Akorino Service


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California Republic, or Bear Flag Republic, was the period of revolt against Mexico initially proclaimed by a handful of American settlers in Mexican California on June 14, 1846.

California Republic may also refer to:
The modern State of California in the United States.
California Republic (mixtape), 2012 mixtape by Game
New California Republic, a fictional government from the Fallout series

redpajama_set_name: RedPajamaWikipedia


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Mery Rui Xu
Home/2019/Contestants/Mery Rui Xu
Mery Rui Xu, China
Born in Beijing in 1996, Mery Rui Xu has dedicated her life to music from a young age, encouraged by her family, especially her dancer mother.
She began piano lessons at the age of four, entering the Beijing Central Conservatory of Music where she studied with Professor Zhao Pingguo.
At the age of 16 she moved to Europe. She entered the Hochschule für Musik "Franz Liszt" in Weimar in the class of Prof. Peter Waas. She is currently based in Lugano, Switzerland, where she's working on a Master's degree at the Conservatorio della Svizzera Italiana.
Mery has won several prizes in many international piano competitions in her native country and abroad. Amongst them were first places at the Xiwang Piano Competition, the 14th Hongkong-Asia Piano Competition, The World Prize for Peace – US International Piano Competition, the 2nd Macau-Asia Piano Competition, and the 9th Concorso Internazionale Giovani Musicisti Premio Antonio Salieri. She also won the Second Prize at the 28th Roma International Piano Competition and the Third Prize at the 56th International Clara Schumann Piano Competition, the 4th International Rosario Marciano Piano Competition, the Primo Concorso Internazinale Luigi Valperga di Masino, and the International Competition for Piano and Orchestra Città di Cantù-Italy.
She enjoys performing both solo and chamber music programs, and she performed as soloist with the Bacau Philharmonic Orchestra Mihail Jora and Orchestra of Conservatorio Svizzera Italiana. She has been invited to play concerts in China, Germany, Italy, and Switzerland. Her recital at LAC in Lugano was reported by RSI TV News.
Mery is an avid chamber musician and she regularly performs with singers and violinists.
She has attended masterclasses with Bernd Götzke, Jacob Leuschner, Anna Malikova, Homero Francesch, and Paolo Bordoni.
Competitor: Second Triennial Olga Kern International Piano Competition. October 27–November 3, 2019. Albuquerque, New Mexico.