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CA: Pro-Gun Event Prompts 'Content Warning' From Student Activists
Submitted by: David Williamson
Website: http://constitutionmetwork.com
A student-run group at California State University, Chico warned classmates to �be safe� and �avoid the area� Monday when a conservative student group held a pro-gun event on campus. The Gender and Sexuality Equity Center (GSEC), a student-run organization sponsored by student government, took to social media on Monday, issuing a �content warning� to alert students that the Chico State Republicans were broadcasting their support for the Second Amendment and inviting passersby to engage in discussions about the topic.
Colorado Gun Rights Activists Fired Up over Proposed Boulder Ban
Colorado gun rights activists are likely to jam the city council meeting in Boulder this Thursday evening to weigh in on a controversial proposal to ban the sale and possession of so-called �assault weapons� and magazines that hold more than 10 cartridges, according to the Daily Camera.
One local gun retailer, Frederick Barton at Bison Tactical, one of two gun stores in the city, told Liberty Park Press that the proposal will likely get lots of opposition. It might also attract legal action. The council is actually going to formally set the meeting during its regular Tuesday evening session, with this explanation.
NM: Police-Homeowner Shot Suspect During Home Burglary
Albuquerque Police are on the scene of a residential burglary that they say ended with the homeowner shooting the suspected burglar. It happened in the area near Harper and Wyoming in northeast Albuquerque.
Florida, the 'Gunshine State,' Tries on New Role: Gun-Control Bellwether
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Jake Decardenas, a Daytona Beach 20-year-old, may not have had his gun taken away. But his attempt to buy a BB gun for his younger brother at Walmart the other day failed. He is one among tens of thousands of young Floridians who had their gun rights curtailed in March in a state that, to a large extent, has defined the modern American gun rights movement.
Igor Volsky: This is How the NRA Uses Fear to Manipulate America
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Igor Volsky is here to warn you that there�s a method to the National Rifle Association�s madness. �The NRA�s core message to its base is fear,� Volsky, the director of Guns Down, told Mic. �Be afraid of the press. The resistance. Immigrants. Muslims. LGBT people. Pretty much anyone who�s not a straight, white, cisgender male.�
FL: Bay County League of Women Voters Hosts Debate on Gun Control
Monday the Bay County League of Women Voters hosted a debate about gun control and gun safety. The debate was held at the Student Union East on the campus of Gulf Coast State College in Panama City. Organizers say they wanted to give those in attendance a look at both sides of the issue of gun reform.
VA Dem on AR-15s: Yeah, Let's Ban Them, But My Party Doesn't Know How To Define Them
Well, not necessarily a shocking announcement, given pro-gun Democrats usually buckle when the pressure becomes this intense: Sen. Mark Warner (D-VA) is reversing his position on so-called assault weapons bans and magazine sizes. The Virginia Democrat is a moderate on the issue, earning a C rating from the National Rifle Association. Not the best, for sure�but one that used to be counted on for voting against his party�s ban on rifles they consider scary.
MI: No Charges for Sheriff Who Left Gun in Middle School Locker Room
Submitted by: Corey Salo
A Michigan sheriff won't face criminal charges for leaving his gun in a middle school.
Mecosta County Prosecutor Brian E. Thiede, through staff in his office, said he declined to authorize charges against Isabella County Sheriff Michael Main. Staff added Thiede found no statute had been violated when Main over the weekend of March 10-11 left his backup handgun in a locker room within Shepherd Middle School, 150 W. Hall St.
A sixth grader at the school had found the Glock 27 on a toilet paper dispenser the morning of Monday, March 12. The student immediately notified school officials, who in turn contacted Shepherd police.
Government Failure and Political Malpractice Kill our Kids..Again
Submitted by: Robert Morse
Website: slowfacts.wordpress.com
Who is at fault for 17 dead children and staff in the Parkland, Florida high school? I assume you feel the same way I do and want to keep our children safe. That means we have to look at what worked to save lives at Parkland. We also have to see what failed in this latest murder. Without that examination, we�re likely to repeat our old mistakes. I don�t want political theater to get in the way of our children�s safety.
That is why we have to ask some tough questions. What worked, what failed this time, and what fails over and over?
PA: McGurl- Stabbing was in Self-Defense
Testifying Monday in Schuylkill County Court in his own defense, Harold J. McGurl Jr. told jurors he had no choice in October 2016 but to stab the man he said was trying to beat him on the streets of Ashland. �He just kept coming at me,� McGurl said of Jordan M. Adams. �The next thing I remember ... is Mr. Adams kicking me in my face. I came up and started swinging my arm.�
6 Essential Practice Tips for a Concealed-Carry Revolver
There is a reason the Roman Legion was one of the most-feared armies of its day. One Legion commander explained it with the quote: �Our training is bloodless battles and our battles are bloody training.� They trained like they fought, and mastered the tactics and equipment they would use. Our elite military units continue that training philosophy today. But, the value of that training concept isn�t confined to the military. Border Patrol legend Bill Jordan once recounted an instance where an officer got involved in a gunfight. His assailant was more than 100 yards away, armed with a rifle chambered in .30-30 Win. The officer only had a .38 Spl. revolver, but he was a highly skilled shooter who practiced regularly.
March NICS Checks Spiked, SAF Blames �Gun Control Hysteria�
A spike in the number of initiated background checks in March via the FBI�s National Instant Check System (NICS) reflects a significant increase in the number of people apparently interested in buying guns, and a major gun rights organization is crediting the wave of gun control hysteria following the shooting tragedy at a Florida high school.
�There is only one reason gun sales may have hit a new record high last month,� suggested Alan Gottlieb, founder and executive vice president of the Second Amendment Foundation, �and that�s the attack on Second Amendment rights that has reached a fever pitch.
VA: LU Shooting Range now Open to Students
The first phase of a sprawling shooting range spread across nearly 600 acres a few miles from Liberty University�s main campus now is open to students and soon will be available to the public. �We�ve been hearing for a long time that students want a place like this to shoot at,� said Brad Butler, planning coordinator in Liberty's Planning and Construction Department.
VA: Lawmakers Press Local Governments to Pass Gun Measures
Lawmakers who were unsuccessful in accomplishing gun control during the General Assembly are shifting their focus to local governments across Virginia.
CA: Chico College Republicans Invites Students to Debate Gun Ownership
Second amendment rights and an open exchange of information about gun control was the topic of conversation and debate Monday, at a tabling event hosted by members of the Chico College Republicans. Michael Curry, executive director, of the group said he got the idea from a YouTuber, Steven Crowder, who made a video �I�m pro-gun, change my mind.� Curry said he thought it would be a good way to have an open conversation at Chico State.
VA: Democrats Organize Task Force to Probe Gun Violence, School Safety
Upset with the lack of gun control consideration by Virginia Republicans, Democrats in the House of Delegates are launching their own group to investigate school safety and gun violence in the state. The caucus announced Tuesday the �Safe Virginia Initiative� task force, a group chaired by two Northern Virginia legislators that will focus on gun control and school safety. The task force will host meetings through October across the state.
OH: Handguns Largely Among Firearms Toledo Police Seize
A gunman with an assault-style rifle five years ago entered a school in Newtown, Conn., and opened fire on students. It happened again during an outdoor concert in Las Vegas, a church service in Sutherland Springs, Texas, and classes in Parkland, Fla. A constant among the killings was the type of weapon. Mass shootings often bring a wide debate on firearms and particular focus on the AR-15-style rifle. But in Toledo, as in many cities, police typically seize illegally possessed handguns at a much greater rate than rifles or shotguns.
Six Myths About the Legendary AR-15
The AR-15 is a legendary American firearm that has become steeped in myth while being maligned by leftists eager to blame the rifle, rather than the criminal who uses it. In the following we dispel six of the more prominent myths surrounding the AR-15.
IL: Illinois City Bans Assault Weapons, Imposes Fines Up to $1,000 Per Day
The Village of Deerfield, Illinois, a suburb north of Chicago, enacted a ban on assault weapons and high-capacity magazines Monday night that carries stiff penalties for those found in violation. The Deerfield Board of Trustees unanimously approved the ban during Monday night�s meeting, although some community members spoke out against it. It will go into effect June 13.
Scammed by a Black, a Woman, and Now a 17-Year-Old
The I.D. (Investigation Discovery) channel re-enacts real-life crime stories. I watched two stories in which single female homeowners heard men breaking into their homes. In both incidents, the best the unarmed women could do was grab their phones, hide in their closets like scared rabbits, and dial 911. My heart went out to the terrified, defenseless women. If they had had guns, the playing field would have been much more level.
IL: Rep. Bill Foster: Second Amendment Meant to be Reinterpreted by Each Generation
Flanked by two area high school students, a pediatrician and the mother of a gun violence victim, U.S. Rep. Bill Foster told a community forum audience Monday the Second Amendment should be up for reinterpretation as new generations come into power.
AZ: ASU Republican Students Call for Gun Control Compromise
The debate over the merits and reach of the Second Amendment heats up with each mass shooting, but rarely does the conversation last more than a news cycle or two. But after the shooting at Florida's Marjory Stoneman Douglas High School and the impassioned advocacy of the shooting's survivors, who through marches and public appearances are calling for stricter gun control, it seems the conversation may have more longevity than usual.
OR: Jefferson County Sheriff Takes Stand on Gun Debate
A Facebook post on a controversial topic by Jefferson County Sheriff Jim Adkins is drawing some attention from residents.
Adkins told NewsChannel 21 on Monday he's not backing down from his post, which was made on Easter Sunday. In the post, Adkins takes a strong stand on the Second Amendment and gun laws and attached a video produced by the National Rifle Association.
TN: Bill to Arm Teachers Fails
A bill that would arm some school teachers in Tennessee failed Tuesday after heated debate from state lawmakers, including several Republican gun rights advocates. The measure was voted down in the House Education Administration and Planning Committee. Legislators wondered whether it was the best way to protect students and whether governments could be held liable for any accident involving an armed teacher.
NJ: State Looks to California for Gun-Violence Research Model
Lawmakers tap Rutgers University, possibly as home for Firearm Violence Research Center that would study all facets of the issue. For years, the gun debate has been obscured by the fact that there is a dearth of objective research on the subject. Given that, New Jersey leaders are looking to build their own body of scientific research on gun violence � including the risks, impacts, and policy implications � based in part on a University of California program that was the first of its kind nationwide.
The Gun Industry Should Send Parkland Three A Gift Basket For Record Firearms Sales In March
Well, if there�s one thing the Parkland Three�Cameron Kasky, Emma Gonzalez, David Hogg�March for Our Lives, and the anti-gun Left can take credit for, it�s the record number of firearms sales that occurred in March. In fact, it�s an all-time high for the month of March; over 2.7 million guns were sold.
Why Giant High Schools Just Can�t Help Messed-Up Kids
As one might expect, the mass shooting in Florida has led to endless commentary about the state of the nation and of the nation�s young in particular. Gun-control advocates predictably exploited the event to call for banning firearms, never questioning the laws already in place, the incompetence of law enforcement, or the effectiveness or plausibility of taking away everyone�s guns. Those in favor of gun ownership trotted out the same responses, and the point has since become mostly moot once more.
MI: Muskegon Police to Standardize Service Guns
Public safety officers are getting new, standardized guns in a lakeside city in western Michigan. The Muskegon City Commission approved a plan last month to spend nearly $50,000 of drug forfeiture money to purchase 90 new 9mm handguns and holsters. Muskegon police officers previously had to buy their own pistols when hired.
Dianne Feinstein After YouTube Shooting: US a 'Nation Awash in Guns'
Sen. Dianne Feinstein, D-Calif., called the U.S. a �nation awash in guns� as she urged for "meaningful" changes to prevent gun violence, following the shooting Tuesday at YouTube�s headquarters in San Bruno. �Only in America is a shooter unleashing gunfire in an office building a common occurrence,� Feinstein said in a statement. �Only in America are people evacuating the scene of a shooting with their hands on their heads a familiar sight.
LA: Bill Banning Teens From Buying Assault-Style Guns
Gaining Steam A bill that would raise the minimum age to 21 for someone looking to buy an assault style-style gun is gaining steam at the Capitol. New Orleans lawmaker Sen. Troy Carter proposed the bill. Tuesday, a Senate committee approved the legislation in a close vote of 4 to 3. The proposed bill would up the minimum age requirement from 18 to 21 for people looking to buy assault-style guns.
PA: Students Start Shooting Team Despite National Gun Concerns
More than a dozen teenagers, many in ball caps and hooded sweatshirts, packed a sun-splashed meeting room of the Erie County Sportsmen�s League with their parents on March 25 for the start of the Fort LeBoeuf Trap Team�s inaugural season. They gathered at the Waterford Township facility for an orientation meeting, but also for a safety meeting, eight days in advance of their first practice and less than a month before the first of five weeks of competition. The agenda that Sunday included introducing the teens to the team�s head and assistant coaches, and going over lessons such as identifying different types of shotgun shells.
FL: Two Boys Arrested Posting Guns on Snapchat
Paso Robles police responded to Paso Robles High School Thursday morning to investigate reports that a 16-year-old former student was circulating photos via the social media app Snapchat depicting himself holding a pistol and displaying rifles. Students screen-captured the photos and showed them to school officials. Police and school officials quickly determined the social media post did not pose a threat to PRHS. The police arrested the former student and another 15-year-old student at PRHS in connection with illegally possessing the pistol depicted in the post.
Seattle Police Confiscated 27 Firearms Since July Under �Extreme Risk Protection Order�
Seattle police have lawfully confiscated 27 firearms from residents since July 2017 thanks to the help of a new �Extreme Risk Protection Order.� Washington is one of six states (California, Connecticut, Florida, Indiana and Oregon) with red flag laws. 18 other states, and the District of Columbia, have proposed adopting similar measures in the wake of the Parkland shooting.
A militia, when properly formed, are in fact the people themselves...and include all men capable of bearing arms. � Richard Henry Lee, Additional Letters from the Federal Framer (1788) at p. 169


I've noticed that a number of brick-and-mortar stores have begun asking me for the last four digits of my credit card when using that mechanism to pay for my purchase. When asked about this, I've been informed that some people have been replacing the magnetic stripe on the card with a different one, so that the numbers on the magstripe are different from the numbers imprinted on the card.
In most instances so far, I have been asked to verbally recite the numbers, or to type them into a keypad. I fail to see how this prevents the sort of card counterfeiting it is intended to stop. If I really wanted to execute this kind of crime, I would merely have to purchase a tank of gas with the phony card first: almost all gas stations print the last four digits of the card on the receipt!
The only meaningful way to prevent this kind of fraud is if one were asked to surrender the card, so that the clerk could verify the digits themselves.


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Get ready to indulge in the deliciously cheesy carbs that we know and love so much -- There is no greater comfort food than mac and cheese!
Maryland has created the Baltimore Mac and Cheese Festival to give us the ultimate day of comfort food! Make it your cheat day, and enjoy yourself because you don't want to miss out on this!
The event will have tons of vendors with multiple macaroni and cheese varieties for you to sample, vote on, and choose your favorite. The winner gets a $500 prize!
WHEN: Saturday, May 18 | 12 p.m.–6 p.m.
You must be at least 21 to purchase alcohol! Have your ID handy!
The event has both self and valet parking; check it out here!
Entry tickets cost $20 in advance and $30 the day of, but they only include admission to the festival (live entertainment and atmosphere). All food and drinks, including tasting samples, are a la carte.
General admission tickets cost $40 in advance and $50 the day of. They include admission to the festival, as well as 10 mac and cheese food tickets and five drink tickets.
VIP tickets cost $50 in advance and $60 the day of. With a VIP ticket, you enjoy one-hour early access, the private VIP area, a private tent, limited seating, 10 mac and cheese tickets, five drink tickets, one cocktail, and more!
Be sure to purchase your tickets because they are selling out quickly -- get them here! For more information about the event, visit the event website or the event Facebook page.
Are you excited for the Mac and Cheese Festival? Are you wearing your stretchy pants? Tell us in the comments below!
Here are the eight things that make Maryland unique from other states!
Check out Maryland's Our Community Now homepage for more local news, events, and features!


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Introducing a resolution this week, Gaetz pointed out a longtime Trump ally, Roger Stone – who pleaded not guilty after he was arrested for allegedly lying to Congress – while others go unpunished.
"That stops today," Gaetz wrote on Twitter, discussing his bill.
Lying to Congress is a serious offense. Unfortunately, it appears certain people have the book thrown at them while others face no consequences at all.
Clinton said "there was nothing marked classified on my e-mails, either sent or received," but it was "proven untrue" by FBI and the Office of the Inspector General reports, according to the resolution.
Additionally, the resolution states that Holder "provided false information" about the "Fast and Furious" program, along with two other instances of providing false information.
Gaetz's resolution also targets former Director of National Intelligence James Clapper, former CIA Director John Brennan, former Deputy FBI Director Andrew McCabe and former Director of the Exempt Organizations Unit of the Internal Revenue Service Lois Lerner.
The problem with this is the act of lying to Congress happened after the fact and should have never have happened but Sessions recused himself. This has cost the taxpayers millions- that money could have been used for Meals on Wheels or free lunch for school children.


Hakim Archuletta has worked within the healing arts profession for over 30 years. His first formal studies were in the Fine Arts which he studied in the 1960s in Berkeley where his expertise ranged from graphic arts to theater, cinema and ethnomusicology. He studied homeopathy and apprenticed in London in the early 1970s. Thereafter, he continued his studies in the Middle East, England and North Africa in the mid 1970s and in Pakistan in the late 1970s, where he earned the title of "Hakim". Returning to the Americas in 1980, he began teaching students privately and established a family practice clinic in Santa Barbara, California. Today he lectures and teaches classes and workshops nationally. In this interview, he puts a different spin on the concept of 'productivity' and discusses the importance of 'being connected'.
Can't see the audio player in your email? Click here to access it and listen to the interview.


text:
Afghanistan extends ceasefire with Taliban
NPR– Afghan President Ashraf Ghani announced on Saturday that his government's ceasefire with the Taliban will be extended another day, even as a suicide bombing killed and injured dozens.
It was a historic truce. The Afghan government declared the ceasefire in honor of Eid al-Fitr, which marks the end of Ramadan. The Taliban announced its own three-day ceasefire – the first one since the United States invaded Afghanistan in 2001, according to media reports.
In place of fighting were scenes of Afghan and Taliban forces praying together, hugging and taking selfies. A member of the Taliban posed in a picture with a female official.
"I am beside myself," one person posted on Twitter. "What an [incredible] magical moment in Afghanistan this #Eid. A Talib hands members of the #ANSDF (Afghan forces) red roses."
The explosion occurred in the eastern province of Nangarhar around 5:15 p.m. local time, according to CNN. Civilians, security forces and members of the Taliban were reportedly among the casualties.
Afghan volunteers bring a man injured in the bombing on Saturday to a hospital. Noorullah Shirzada/AFP/Getty Images
ISIS claimed responsibility for the attack, targeting "a gathering of Afghan forces." At least 26 people were killed, according to Reuters.
It is unclear when Ghani learned about the bombing. He told citizens in a televised address that he ordered security forces to extend the ceasefire.
"To respect the public's wishes and to support their demands about peace, I am ordering the security and defense forces to extend the ceasefire from the fourth day of Eid," he tweeted.
He also asked the Taliban to extend its ceasefire, saying that his government will provide medical and humanitarian aid to wounded members of the Taliban. He said 46 Taliban prisoners had been released, according to Tolo news service, and that prisoners will be "allowed to contact and see their families."
Western leaders embraced his announcement to prolong the ceasefire. In a written statement, U.S. Secretary of State Mike Pompeo said, "The United States stands ready to work with the Afghan government, the Taliban, and all the people of Afghanistan to reach a peace agreement and political settlement that brings a permanent end to this war."
He also said that peace talks needed "a discussion of the role of international actors and forces."
NATO Secretary-General Jens Stoltenberg said, "This is a unique opportunity for the Taliban to show they want the peaceful future that the Afghan people demand and deserve."
The Taliban's council plans to meet on Sunday to discuss President Ghani's offer, The Guardian reported. A senior council member said the ceasefire could be extended if a date was established for U.S. forces to withdraw from Afghanistan.
Afghanistan, Ashraf Ghani, Taliban	June 17, 2018
Iran not meddling in Iraq's internal affairs: Sadr Movement
Iran hails extension of ceasefire in Afghanistan

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Descripció feta a partir de: Vol. 28, no. 1 (Mar., 1998), el 30 març 2004.
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'The Pirates: Goblin Flag' Will Show Ambitious Pirates on the Thrilling Hunt for Treasure
by krishkim December 29, 2021, 2:32 PM
The sequel of 'The Pirates', which drew 8.66 million viewers, will be released in theaters next month.
Credit: Lotte Entertainment
The Pirates: Goblin Flag follows the journey of pirates in finding the lost treasure of a royal family, which disappeared without a trace. At an online press conference on the 29th, director Kim Jung Hoon shared, "I'd be lying if I said that there was no pressure since the first movie was such a success." He added, "I filmed the action and adventure more realistically so that the audience can experience it rather than just watch it."
Kang Ha Neul and Lee Kwang Soo turned into familiar characters. Since the two actors have worked together before, they showed exceptional chemistry. It is said that there was no need to film the same scene twice if the stars were Kang Ha Neul and Lee Kwang Soo.
The Pirates Goblin Flag
Despite playing the role of Moochi, who claims himself to be the best swordsman in Joseon, the role that Kang Ha Neul wanted to play was Haerang, played by Han Hyo Joo. "Actually, when I first saw the scenario, Haerang seemed really cool. From her charisma to her lines, everything was cool," he shared. And to play Haerang, Han Hyo Joo had to "put on a different face." The actress underwent intense training in swordsmanship, wire action, and underwater filming for the role.
Two actors that caught attention were Kwon Sang Woo and EXO's Sehun. First, Kwon Sang Woo will play his first villain role as Boo Heungsoo. Director Kim jokingly added, "I turned Kwon Sang Woo into such a loser in my precious movie, so I wanted to capture his charm and charisma this time." On the other hand, Sehun makes his big-screen debut as Hangoong, a skilled marksman. "I'm glad I filmed this movie because I've met such amazing people."
The Pirates: Goblin Flag boasts cinematic beauty, such as a model ship reminiscent of a real pirate ship and a giant filming set. The filming even took place in Jeju Island, boasting a great overall view.
Lee Kwang Soo shared, "When I first saw the magnificent set, I thought, 'Wow, I'm finally making a movie like this.' I felt a sense of pressure, but my self-esteem also increased."
Meanwhile, the movie is slated to be released during the Lunar New Year holiday.
Han Hyo JooKang Ha NeulKwon Sang WooLee Kwang SoomovieSehunThe Pirates Goblin Flag
Grammy Awards Rescheduled to April 3rd in Las Vegas; Is BTS Headed For Their First Grammy Win?


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Emerging Role of MicroRNAs in Reproductive Medicine
Nasser Chegini1
1Professor, Department of Obstetrics and Gynecology, University of Florida, Gainesville, Florida
Early during summer 2007, I was asked by Dr. Carr to serve as the guest editor for an issue of Seminars in Reproductive Medicine. Selection of a topic relevant to my field of research that would be of interest to general readers of the journal was rather challenging considering the many outstanding articles that were published in previous issues of the journal in past years. However, I became quite convinced that the subject of microRNA (miRNA) in reproduction would be ideal because it has emerged as one of the most active research topics in various fields of biology and medicine in recent years. Comparatively, the miRNA-related research in reproductive biology and medicine is in its early stage of development but will undoubtedly evolve through in-depth investigations. These highly conserved, small, non–protein-coding RNAs have emerged as key regulators of translational efficiency of their complementary target messenger RNAs (mRNAs) from plants to viruses, nematodes, fruit flies, and animals, including humans. In this issue of Seminars in Reproductive Medicine, several articles present evidence regarding the implication of the regulatory function of miRNAs in pituitary, ovarian, uterine, and breast gene expression under normal and pathologic conditions.
During the past decade, large-scale gene expression microarray has generated comprehensive information reflecting the molecular signature of various cells and tissues under normal and disease conditions. Although the acquisition of such large genomic data has been highly informative, it has also created the challenge of how to integrate such knowledge to sort out the individual and interactive mechanisms that regulate the expression of these transcripts resulting in implementation of their appropriate biological functions. Despite considerable progress, the significance of the expression of a large number of these transcripts remains unknown, and because of their diversity, predicting their biological relevance has become more complex than was originally envisioned. Adding to this complexity was the recent discovery of miRNAs and their emergence as one of the major components of the individual and interactive mechanisms that regulate gene expression.
Since the cloning of the first miRNA, lin-4, in Caenorhabditis elegans a decade ago, several hundred more miRNAs have been identified in various species, including human.[1] Genomic analysis revealed that the genes encoding miRNAs are scattered in all chromosomes except the Y chromosome and are estimated to constitute ~1 to 4% of all known genes in higher organisms. In addition, ~50% of the miRNA genes are found in clusters and, due to a high degree of relatedness among them in each cluster, they may have derived from gene duplication. Nearly all the miRNAs identified are conserved in closely related species, or many have homologs in distant species, implying their conserved functions throughout evolution.[2] [3] The primary miRNA transcripts, or pri-miRNAs, are several kilobases long and undergo substantial processing resulting in the generation of a small, 70- to 90-nucleotide (nt) stem-loop precursor miRNA (pre-miRNA) in the nucleus. The pre-miRNAs are transported into the cytoplasm, where they undergo a second cleavage by the cytoplasmic RNase III, Dicer, generating a double-stranded miRNA duplex.[4] [5] [6] The double-stranded miRNA duplex unwinds and forms a single-strand, mature miRNA that incorporates into the RNA-induced silencing complex (RISC) and through complementary interactions with target genes regulates gene expression mostly but not always through translational repression.[7] [8]
Many putative miRNAs have been identified and/or predicted in the genomes of different species, including 580 identified and more than 1500 predicted in humans. After their identification or prediction, miRNAs are assigned a sequential number; that is, miRNA-1 (miR-1), miR-2, miR-3, and so forth. Numerical and alphabetical suffixes are used to distinguish miRNAs that are generated from more than one locus such as miR-1–1 and miR-1–2, and so forth, or to identify miRNAs that differ by a small number of bases such as miR-23a and miR-23b, respectively. miRNAs with a hairpin precursor giving rise to two miRNAs are distinguished by the arm they are generated on, that is, miR-17–5p (5′ arm) and miR-17–3p (3′ arm), and an asterisk identifies the less expressed species, such as miR-199a*.[1] [2] [3] [4] [5] [6] The specificity of miRNAs is dictated by at least 6 to 7 nt that bind to the 3′ untranslated region (3′ UTR) of their target mRNAs. As a result, a single miRNA can potentially target hundreds of genes, or a single gene could be a potential target of many different miRNAs. The biological significance of such diversity is unclear; however, it may serve as a mechanism to achieve different levels of gene regression possibly based on a cell-specific functional requirement. As such, depending on the degree of complementary sequence homology with their target genes, binding of several miRNAs may become necessary to establish full regression of specific target genes.[9] [10] Because of this complexity, to date ~70 to 100 specific gene targets have been functionally verified and experimentally confirmed.
Accumulated data has been generated regarding the expression of many miRNAs in several normal cells and tissues, with aberrant expression of a specific number of them in various disorders, more specifically cancers.[11] [12] [13] To provide insight into the diverse role of miRNAs in reproductive organs, for this issue of the journal several of my colleagues were invited to review the emerging field of miRNAs research in their respective areas of expertise. Maria Chiara Zatelli and Ettore C. degli Uberti discuss the expression and possible role of miRNAs in the pituitary. Their research team was the first to report the expression of miRNAs in pituitary adenomas and correlate miRNA expression with tumor histotype, differentiating microadenomas from macroadenomas and treated from nontreated patients compared with normal pituitary.[14] Clearly, pituitary gonadotropins are essential for many of the ovarian biological activities and subsequently other reproductive tissue physiologic functions. Han Zhao and Aleksandar Rajkovic present evidence for the expression and involvement of miRNAs during ovarian development. Their research team has recently reported that the lack of Nobox perturbs global expression of genes preferentially expressed in oocytes as well as ovarian expression of miRNA compared with that in wild-type ovaries.[15] Whereas the potential regulatory functions of miRNAs in human ovary remain to be elucidated, Tannaz Toloubeydokhti and colleagues discuss such a possibility by incorporating data obtained from mice during oogenesis and ovarian development and observe the relevance of miRNA expression to ovarian physiology and altered expression in ovarian cancer and polycystic ovary syndrome in humans. In addition, the authors discuss the expression of several of these miRNAs in granulosa/cumulus cells obtained from women undergoing oocyte retrieval for assisted reproduction and their potential regulatory function in gene expression essential for sex steroids biosynthesis and other ovarian physiologic functions.
Whether regulated independently or through an ovarian steroid–dependent manner, gene expression in uterine and other ovarian steroid target tissues is subjected to transcriptional and translational regulation. In this regard, Qun Pan discusses the result of miRNA expression signature and regulatory functions in the endometrium during normal and disease states such as endometriosis, endometrial cancer, and dysfunctional uterine bleeding.[16] This is followed by an article from Warren B. Nothnick that describes the role of miRNAs in regulation of uterine matrix metalloproteinase-9, a key enzyme in tissue turnover and angiogenesis. Uterine fibroids, which occur in a substantial number of women during their reproductive years, are also ovarian steroid sensitive tumors that tend to develop more frequently in African Americans than they do in other ethnic groups. The expression and potential regulatory function of miRNAs in the pathogenesis of leiomyomas is presented by Xiaoping Luo, and Jian-Jun Wei and Patricia Soteropoulos discuss miRNAs as a new tool for biomedical risk assessment and target identification in uterine leiomyomas.[17] [18] To conclude this issue, Brian D. Adams and colleagues present evidence for the involvement of miRNAs in pathogenesis of breast cancer with specific reference to estrogen receptor regulation by miR-206.[19]
It has become clear that miRNAs serve as key regulators of gene expression, and our understanding of their functional relevance in normal biological and disease processes is exponentially growing. We are just beginning to unveil the biological significance of miRNA expression and function in reproductive tract cells and tissues with many major challenges to uncover. These include, but are not limited to, hormonal regulation of miRNA expression and functional regulation of specific target genes with critical role in various reproductive tract tissues. Additionally, assessing the expression profile of miRNAs along with their target genes would allow us to identify if aberrantly expressed miRNA is associated with establishment and progression of a particular reproductive disorder or if the changes are the consequence of disease in comparison with normal tissue counterpart. It is also necessary to elucidate what locally expressed factors, specific or nonspecific, modulate the miRNA target recognition and repression and if these activities are cell and tissue specific. There is also a need to determine the specific expression signature of miRNAs in response to hormonal therapies for various reproductive abnormalities, reproductive aging, specifically in the case of the ovary, as well as transition from normal to cancer states. Interestingly, the miRNA signature has been a much more reliable discriminatory value compared with mRNA profiling between normal and cancer tissues and different tumor subtypes. As discussed, in pituitary and breast cancer as well as in several other tumors, the pattern of miRNA expression correlated well with pathologic features of the tumor indicating the possible prognostic use of miRNA profiling along with other well-known prognostic features.[12] [13] Collectively, such progression in miRNAs research would not only allow us to uncover the fine tuning of gene expression regulation and new regulatory mechanisms,[20] but also it may lead to complementary approaches to define the diagnostic usefulness of miRNAs in various reproductive disorders including cancers.
1 Lee R C, Feinbaum R L, Ambros V. The C elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993; 75 843-854
3 Farh K K, Grimson A, Jan C et al.. The widespread impact of mammalian microRNAs on mRNA repression and evolution. Science. 2005; 310 1817-1821
4 Cullen B R. Transcription and processing of human microRNA precursors. Mol Cell. 2004; 16 861-865
5 Lee Y, Kim M, Han J et al.. MicroRNA genes are transcribed by RNA polymerase II. EMBO J. 2004; 23 4051-4060
6 Borchert G M, Lanier W, Davidson B L. RNA polymerase III transcribes human microRNAs. Nat Struct Mol Biol. 2006; 13 1097-1101
7 Shyu A B, Wilkinson M F, van Hoof A. Messenger RNA regulation: to translate or to degrade. EMBO J. 2008; 27 471-481
8 Eulalio A, Huntzinger E, Izaurralde E. Getting to the root of miRNA-mediated gene silencing. Cell. 2008; 132 9-14
10 Ku G, McManus M T. Behind the scenes of a small RNA gene-silencing pathway. Hum Gene Ther. 2008; 19 17-26
11 Stefani G, Slack F J. Small non-coding RNAs in animal development. Nat Rev Mol Cell Biol. 2008; 9 219-230
12 Calin G A, Croce C M. MicroRNA signatures in human cancers. Nat Rev Cancer. 2006; 6 857-866
13 Calin G A, Croce C M. Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications. J Clin Invest. 2007; 117 2059-2066
15 Choi Y, Qin Y, Berger M F, Ballow D J, Bulyk M L, Rajkovic A. Microarray analyses of newborn mouse ovaries lacking Nobox. Biol Reprod. 2007; 77 312-319
16 Pan Q, Luo X, Toloubeydokhti T, Chegini N. The expression profile of micro-RNA in endometrium and endometriosis and the influence of ovarian steroids on their expression. Mol Hum Reprod. 2007; 13 797-806
17 Pan Q, Luo X, Chegini N. Differential expression of microRNAs in myometrium and leiomyomas and regulation by ovarian steroids. J Cell Mol Med. 2008; 12 227-240
18 Wang T, Zhang X, Obijuru L et al.. A micro-RNA signature associated with race, tumor size, and target gene activity in human uterine leiomyomas. Genes Chromosomes Cancer. 2007; 46 336-347
19 Adams B D, Furneaux H, White B A. The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-alpha (ERalpha) and represses ERalpha messenger RNA and protein expression in breast cancer cell lines. Mol Endocrinol. 2007; 21 1132-1147
20 Filipowicz W, Bhattacharyya S N, Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?. Nat Rev Genet. 2008; 9 102-114


The new Surface Precision Mouse helps you stay productive, efficient, and in the flow with flawless transitions, patented magnetic scrolling for precise control, and a customizable design with three programmable buttons. It even foregoes the new USB-C standard and gives you a good, old-fashioned USB-A port, so it should be much easier to find accessories that work without requiring a dongle. It also has a magnetic Style and speed. Go beyond the traditional with Surface Laptop 2. Featuring improved performance and the full Windows 10 Home experience, slip it in your bag and make every day more productive. Microsoft Surface Pro review: the Microsoft says this Surface Pro is completely redesigned inside and out, but you'd probably have trouble telling it apart from its immediate predecessor, 2015's Surface Pro 4. Tags: microsoft, surface, review, normal, Microsoft's Surface Go starts at $399 and is a computer if you buy the right model and accessories, but it's not a tablet. Most people should consider a Surface Pro, Chromebook or iPad Did you know there's a Surface Studio? Check out our Surface Studio 2 review. While the high price of the Surface Studio may have turned you off, the all-in-one PC for creatives has The Surface Pro 6 is the latest version of Microsoft's category-defining detachable tablet but do a price cut, faster chips and a paint job make it worth buying?


The Lady Jays junior varsity basketball team picked up their 11th victory of the season in the Don Patton Gym on the 11th of February. The Lady Jays who hosted the Lady G-Men of Garretsville Garfield High School took the lead early and never looked back throughout the game as they cruised to a 24-5 victory. Sophomore Kelsie Taylor led the way with 10 rebounds and 7 points on the night. Freshman Kylie Wilson had 9 points on the night with Junior Alyssa Deak adding in 7 rebounds with 6 assists. If you have not checked out the Lady Jays junior varsity basketball team yet this year come on out Thursday as the team will host Lisbon in a two quarter game starting at 6:15 PM in the Don Patton Gym.


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CRAIN'S: Housing Partnership CEO Jamie A. Smarr outlines 4 steps to address the city's affordable housing crisis >> Read more
240 Manhattan Avenue
Morningside, Manhattan
14 Affordable Homeownership Units
Our Role:
Not-for-Profit Sponsor
Inclusionary Housing Administering Agent
Developer: Artimus Construction
One Morningside Park is a high-rise condominium in Manhattan with expansive views. Completed in 2014 by Artimus Construction with the Housing Partnership as the nonprofit sponsor, the building is located at the crossroads of two major New York City parks: Central Park and Morningside Park. The project is a model for private/public collaboration, combining privately owned land with HPD's Inclusionary Housing Program. Of the 69 apartments, 14 were made available to families earning less than 60% of Area Median Income. Starbucks occupies the retail space fronting on West 110th Street. The building's units all feature luxury appliances, individual heating and cooling systems, and superior finishes in the bathrooms and kitchens. Many units also have terraces and balconies, and the building has indoor and outdoor recreation space for unit owners with a shared rooftop 23 stories above the ground.
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Bernard Fianku
Bernard lives in Accra, Ghana and has spent his career improving the lives of others. He has been involved in various avenues of counseling as well as leadership positions for groups devoted to children's causes. This includes a director of an academy along with creating programs, services and vocational training for orphaned children. Today, he is Country Director for a group rescuing enslaved children and CEO of a Soccer Club he founded for homeless children. Bernard serves Isaac's Dream by overseeing construction and operations of all projects
Brett Clemens
Brett, a native of Kansas City, serves with Perspectives on the World Christian Movement as the Central States (KS,MO,NE and IA) Regional Director. Perspectives USA's mission is to mobilize by educating the body of Christ in the USA to strategic engagement in God's global purpose. Upon graduating from Northwest Missouri State University with a BA in Corporate Finance/Financial Computing and an MBA in General Business, Brett entered the business world. From 2007-2016, Brett worked at Hallmark Cards as a financial analyst. In 2016, Brett left the business world to become a full time mobilizer through Perspectives. Brett is married to Colette, and they have three children: Brylynn, Cora and Brecken.
Colette Clemens
Colette, a native of Kansas City, currently works as an Adjunct Professor at a local college and stays at home with her three children, Brylynn, Cora and Brecken, where she home schools part time. Upon graduating Northwest Missouri State with a BA in K-12 Physical Education and K-12 Health Education she worked for seven years as a physical educator in a local school district, eventually staying home with her growing family.
Colette loves to spend time with her family and loves to serve others. In her free time, she enjoys being active with her kids and husband.
Mendy Shriver
Mendy is an energetic mother to 5 teens, 2 of which are adopted from Sierra Leone, West Africa. She's been married to her high school sweetheart for 21 years and has a BA in Marriage/Family Counseling with a minor in Religious Studies from Oklahoma Baptist University. Mendy is a "super advocate" for ZOE International and has traveled to West Africa several times.
Mendy enjoys speaking, coaching, and writing about women's health and fitness issues. She is the co-founder of the growing Christian social media ministry, Real Raw Redeemed. Mendy is passionate about finding more effective orphan care solutions on a global level. She loves God's word and desires for women and little girls to understand that "healthy living begins in our hearts."
For fun, Mendy loves weekends at the lake with her family, cycling with friends, and laughing till her face hurts.
Derek Kreifels
Derek is the President of the State Financial Officers Foundation (SFOF). As President of SFOF he is charged with leading the national organization and collaborating with state elected officials to promote fiscally responsible, free market principles to better impact state and federal financial policy. Kreifels is charged with ensuring that SFOF's fiscal, operational, fundraising, marketing, and communication strategies are effectively implemented. Kreifels and his team organize two national meetings annually for SFOF members to come together and discuss best practices. He has organized multiple meeting, receptions, and other events across the U.S. including several recent meetings at the White House.
Kreifels has spent the last 20 years advising and working with various federal, state, and local leaders. He served as the Assistant State Treasurer and Chief of Staff to Kansas State Treasurer Ron Estes from 2011 to 2016. Kreifels also spent several years in banking.
He attended Kansas State University, and received his undergraduate degree from Wichita State University and his Masters from Friends University in Wichita, Kansas. He and his wife Melanie live in the Kansas City area.
Melanie Kreifels
Melanie is a licensed professional counselor in Kansas. Her heart for women and children is evident. She has spent time working as a missionary in Glasgow, Scotland, and a brief time in South Africa. She has worked at the women's shelter of the City Union Mission of Kansas City, and several other ministries. She also works with the State Financial Officers Foundation (SFOF) as the Operations Manager.
Melanie graduated with her Bachelor of Science degree from University of Central Missouri in Warrensburg, MO, and her Master of Arts in Counseling from Mid America Nazarene University.
John "Buzz" Billharz
John "Buzz" is a medical doctor passionate about missionary work and caring for children. He is currently working in his own practice, Redwood Pediatrics in Liberty, Missouri, a suburb of Kansas City. Dr.Billharz works in an ongoing capacity with missions efforts on five continents and has extensive international travel experience. He believes education is a vital tool in helping children escape slavery/child labor in rural areas of Ghana, and is committed to helping Isaac's Dream achieve this goal.


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Vote Now to Decide the NBA's Most Stylish Player
This year's NBA Playoffs have felt like a changing of the guard. Ja Morant, Luka Doncic, and Jayson Tatum all made The Leap, while Chris Paul, Joel Embiid, and Giannis Antetokounmpo are watching from home as the Warriors and Celtics face off in the Finals. Heck, LeBron's Lakers didn't even make the playoffs! Things feel new, and new feels good.
One thing that has stayed the same: NBA players are still dressing aggressively, and it seems certain that the NBA is still the most stylish sports league on earth. And so, with the 2022 NBA champ set to be crowned shortly, we'd like your help giving a different sort of award. Welcome to GQ's annual Most Stylish NBA Player tournament.
The 16-player bracket is stacked; there might not be an easy matchup among them. Still, there are highlights: courtside king Ben Simmons will face off against the guy he was traded for (and no slouch, stylewise) in James Harden. Old head P.J. Tucker and will stare down young gun Jaren Jackson Jr. And perennial style all-stars D'Angelo Russell and Kyle Kuzma will go head to head. Things lean a little younger this year—but that should make things interesting.
The league's 16 strongest fit connoisseurs face off, starting NOW, in a five-day, five-round competition to determine the league's best-dressed player. Each round lasts for 24 hours. And it'll all take place on GQ Sports' Instagram. Cast your vote every day, check back here for updates, and stick around to see who hoists the GQ Most Stylish NBA Player trophy at the final buzzer.
PrevGuillermo del Toro's Netflix Horror Anthology Cabinet Of Curiosities Gets Spooky Teaser
NextPackers' Aaron Rodgers in Green Bay for mandatory minicamp, to work with new WRs for first time, per report


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The maximum combined cost of all the valuables (you or any member of the household stand to lose) should give you an idea for how much you insure your belongings for. There's no need to list each item individually. There are limits applied, however, to the cover such as: €2,540 for any individual item, and bicycles up to a limit of €320 in any single period of insurance.
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1. A relatively stable cryptographic currency network which balances the requirements of all parties involved.
This wiki which provides all details pertaining to the software, it's configuration and the rationale of design decisions.


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Nice Films
By writer | January 24, 2020
Drama is a type of literature A drama might be in the type of a novel , television present , movie , play or dance Though drama is a Greek word that means " motion ", most dramas focus more on the relationships between folks than on the actions. Some movies are entertaining, others are life-altering. Not only for the followers but for the forged and crew, who find themselves chargeable for an iconic chapter in cinema historical past that touches millions of lives. This straightforward and interesting collection takes a take a look at among the movies that changed into field-workplace gold in the Nineteen Eighties and Nineties, interviewing the individuals liable for them. We'll uncover behind-the-scenes secrets and techniques, the moments that threatened to halt filming and the eleventh-hour changes we never knew about as we take a trip down memory lane and see some of our favourite films in a whole new gentle.
The present is known not just for its comedy but also for its camera work. We see every little thing from the characters' viewpoint, that means the actors sometimes have cameras strapped to their heads to achieve this impact (significantly!). All of it helps to create the show's unique perspective – while comedies about losers are commonplace, this sequence at all times felt distinctive.
This movie shows Tarantino doing what Tarantino does best: writing unimaginable dialogue performed by the best actors working in the present day. And with the ever-looming risk of the Manson family in the backdrop, there's at all times that sliver of tension that this will not go the way you assume it's going to.
Noah Baumbach's star-studded divorce drama is pure Oscar bait, but in one of the simplest ways. The film takes a have a look at messy breakups with Scarlett Johansson playing an actress and mother named Nicole, who's intent on separating from her stage director husband Charlie (Adam Driver). Laura Dern and Ray Liotta play their laborious-hitting attorneys, who don't help in diffusing the strain and resentment building between the pair when Nicole strikes herself and their son across the country. It is an intimate look at the emotional wreckage of a divorce and the wrestle to place a family back together once more, and it is carried by some sensible performances by Driver and Johansson.
Amy Adams performs a professor of comparative linguistics in this alien first-contact film from Denis Villeneuve, which explores free-will, experiences, reminiscence, and destiny, and masterfully delivers both personal and world messages. Jeremy Renner co-stars.
← How to Care for Your music Immediate Solutions To Actor In Step by Step Detail →


Recently, a report done by health officials from Alberta has stated that the 14 people that came to the hospital with symptoms that mirrored those of influenza were suffering from a variety of respiratory like viruses that are quite common. Our main goal is to tell the backstory behind this and how the situation was resolved.
One Wednesday afternoon paramedics were called to the Stoney Nakoda First Nation after a four-month-old baby girl was found dead on the scene and another child was in a life-threatening condition. Fourteen members of that particular family had to be transported to the Alberta Children's Hospital located in Calgary.
Out of the 14 that were brought to the hospital with respiratory issues, 10 are still hospitalized. This includes the little child that was found in a life-threatening condition who is now stable and on the path to recovery.
When asked to say more about this matter, the Alberta Health Offices did not want to disclose much more on this particular topic. They said that no other individuals are at risk and that the situation is being taken care of by the medical staff. The public should not worry since this is not an unknown virus that is spreading rapidly; this was simply a situation that had to be taken care of. When asked to tell the public how the child died, they said that they are not going to do that out of respect for the child that passed away and his family.
So far the health officials do not know for sure what kinds of viruses were involved but the investigation is still underway. This winter season has brought a wave of flu infections that has been higher than usual, with around 1000 children that were below the age of 16 getting hospitalized up to the end of March.


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John's letter of thanks from the First Minister
When John first found out he would be moving to a brand new housing development with a walk-in shower, he couldn't quite have imagined how things would unfold.
Fast forward…and he's sitting at home opening a letter from none other than the First Minister, Nicola Sturgeon. She had written to him to thank him for sending such a beautiful gift. So, how did this all happen?
John, from Edinburgh, previously lived in an old flat in the west of Edinburgh. As his mobility had deteriorated, the use of the bathroom was a lot more difficult for him meaning that the safest option was to have a bed wash.
Understandably, John was not comfortable with this situation and it was having a noticeable impact on his mood with his team and colleagues at the day centre. To add to this, he was served an eviction notice as the property was being sold to a new owner.
It took his team six months before they could find a suitable home for John that was within his budget. They finally came across LAR Housing Trust, who were building a brand new set of flats in East Lothian.
John's team put in an application which was accepted – and what's more he was to be the first resident to move in!
From this point onwards, John was included in all the big decisions relating to the property; from flooring to bathroom requirements. Due to being the first resident in the development, John was invited to officially open the property alongside the Minister for Housing, Kevin Stewart.
John took along a painted piece of woodwork that had 'Thank You' written across it and asked for Kevin to pass it along to the First Minister.
Lo and behold, the First Minister wrote to him in person thanking him for the heart-warming gift. As you can imagine, John was absolutely over the moon!
John now lives in a beautiful flat that has a spacious walk-in shower and looks right over the local harbour. A happy ending all round!
Author: Heather King
Carr Gomm Healthy Living & Wellbeing Project - Phase 2
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WASHINGTON � When a pope meets a president � and the Vicar of Christ gets pulled into political coverage � trivialization ensues. I covered the St. Louis meeting between Pope John Paul II and Bill Clinton in January 1999, not long after the president admitted to �intimate contact� with Monica Lewinsky. There was wild speculation that, well, what? That the pope would force Clinton to kneel in penance in the snow like Henry IV? That if they touched hands, it would cause spontaneous spiritual combustion?
In the current round of coverage, we have been treated to comparisons between the approval ratings of President Barack Obama and Pope Francis, and analysis about similarities between the Democratic and the Vatican platforms. Obama supporters emphasize the remarkable overlap of agendas � on everything except life, marriage and religious liberty. In the run-up to the meeting, Sen. Rand Paul, R-Ky., challenged Obama to �explain to the pope� his views on the Hobby Lobby case � while holding a libertarian political philosophy at odds with Catholic social thought on most points.
The enterprise of handicapping the papal primary is absurd. Catholic teaching stands in judgment of both ideological sides in American politics, as one would expect of a faith that combines moral traditionalism with a belief in social justice. And though it is sometimes hard for Americans to comprehend, the church is working on projects and problems � like grace, mercy and original sin � that preceded the American experiment and will outlast it. That said, popes have been known to employ political skills in divine purposes. And here, Pope Francis seems particularly blessed. In a recent session at the Faith Angle Forum, papal experts John Allen, associate editor at The Boston Globe, and Paul Vallely, author of �Pope Francis: Untying the Knots,� described Francis� first year as one of the more consequential in recent church history.
This has been more than public relations, but not devoid of public relations. Francis has a feel for powerful symbols of simplicity, humility and compassion, such as carrying his own suitcase, washing the feet of Muslim prisoners, inviting the homeless to his birthday party, touching the disfigured. In this case, old Coke is pretty old � the example of a wandering preacher who touched lepers and consorted with sinners and outcasts. As in that ancient example, Francis has combined traditional moral teachings with a scandalous belief that people are ultimately more important than rules.
Francis speaks of mercy with the passion of a man who has received it and was never the same again. This virtue � showing mercy to others and accepting God�s pity on our own pitiful hearts � is perhaps the least political of the virtues. Also the most humane.
Correction: In my March 21 column on the possible effect of �Obamacare� during the next election, I wrote that in Iowa, health care premiums were expected to rise by 100 percent. I learned my source, which called the prediction recent, was actually describing a year-old prediction. Rates apparently are now not expected to rise nearly as much.
Michael Gerson�s email address is michaelgerson@washpost.com.


text:
Ángel Custorio Vásquez Galdames fue un ingeniero y Senador chileno. Nació en 1876 hijo de Ángel Custodio Vásquez y de Petronila Galdames Orellana. Casado con Isolina Flores, con la cual tuvo 5 hijos.

Estudió en la Escuela de Minas de Copiapó (actual Universidad de Atacama) donde se tituló de Ingeniero.

En 1896 ingresó a las filas del Partido Radical, alcanzando altos cargos, teniendo la misión de organizar el partido en Calama y reorganizarlo en Antofagasta. En 1938 fue designado presidente del Frente Popular.

Trabajó durante 26 años en el Ferrocarril Antofagasta-Bolivia. Fue empresario de la construcción. Formó parte de importantes organizaciones sociales como la Sociedad de Instrucción Primaria entre otras además creó diversas instituciones de ayuda a los más desvalidos y de promoción popular como la Sociedad de Artesanos de Copiapó y la de Antofagasta entre muchas otras sociedades de este tipo no solo en el norte de Chile.
En Chuquicamata formó la Biblioteca Popular, la primera de su tipo en la zona y cuyo intención era acercar a obreros y trabajadores a toda clase de libros puesto que la única biblioteca existente solo contenía textos de carácter técnico de escaso valor literario.
En Pueblo Hundido (actual comuna de Diego de Almagro) creó la primera escuela primaria del pueblo, el cual carecía de todo tipo de institución de enseñanza.

En 1947 se desarrolló una elección complementaria para reemplazar al senador Gabriel González Videla quién había dejado el cargo al asumir como Presidente de la República, en esta elección Ángel Custodio Vásquez fue elegido Senador de la República por la 1º Circunscripción de Tarapacá y Antofagasta para el período comprendido entre 1947 y 1953, participando en diversas comisiones.
Presentó varios proyectos de ley, algunos de los cuales se convirtieron en ley como la que materializó a la Escuela de Minas de Antofagasta (creada pero no puesta en funcionamiento), y la internación desde el extranjero libre de todo impuesto de materiales para la Municipalidad de Arica.

El senador Vásquez Galdames luego de su retiro de la política activa, se dedicó por completo a sus actividades empresariales en el rubro del turismo y en esta condición fue director del Consorcio Hotelero de Chile.

Falleció a los 91 años, el 1 de octubre de 1967.

Enlaces externos
Reseñas Parlamentarias Biblioteca del Congreso Nacional de Chile

Bibliografía
-Biografías de chilenos miembros de los Poderes Ejecutivo, Legislativo y Judicial 1876-1973/Armando de Ramón Folch, comp.--Santiago, Chile:Ediciones Universidad Católica de Chile, 1999.--V.3.
-Catálogo Parlamentario;Listas de Parlamentarios;Fichas Biográficas;Diccionario Biográfico, 11º edición,(pág.1347-1348).

Radicales de Chile
Ingenieros de Chile
Alumnado de la Universidad de Atacama

redpajama_set_name: RedPajamaWikipedia


Electro swing is the mix of modern electro beats, swing sounds and the aesthetics of the early decades of the twentieth century.
Again and again, new, exciting bands revive the scene with innovative elements.
At least since the success of the TV series BABYLON BERLIN, this style is again on everyone's lips and enjoys great popularity.


This past weekend I attended my very first Alt Summit Salt Lake City- an enormous and highly anticipated conference for bloggers and social media gurus held at the beautiful Grand American Hotel. I was there with the Blurb Books entourage, who generously invited me along to set up my Instant Polaroid Photobooth at their Winter Olympics themed Alt party. A free business trip full of schmoozing, learning, and a super fancy hotel? Sign me up! Though I'm not much of a blogger (but I do love to blog here and there), I did take the opportunity to network with some really smart and kind women (I was one of five men in the entire conference. The ladies were nice to me.), as well as attend a few enlightening classes and seminars. But the real work happened on the last night of the conference where the Blurb team and I put on a wild, wintery party to promote Blurb's amazing self-publishing platform and beautiful books (of which I use exclusively for all my self-publishing. Haven't seen my Blurb Bookstore? Click on over with this link: www.blurb.com/user/store/jfreidin to preview and purchase my latest dog photography books).
Not knowing how many people to expect at the photobooth, I decided to play it safe and buy a few extra packs of instant film, just in case we needed them or something went horribly wrong. The moment the doors opened, I had people posing in front of the camera for four hours straight. This is not an exaggeration. There were winter olympic themed props, as well as an olympic posing podium- all of which made for wonderfully fun and entertaining polaroid portraits. I shot the instant portraits with my Fuji Fotorama, and as per usual it was a great conversation piece. I had an amazing assistant who flawlessly developed and peeled all 160 portraits from the evening- which I'm pretty sure is a photobooth record for me. Everyone had a great time, loved their polaroids, and at the end of the night I only had two back-up packs of instant film left. Also, I was surrounded by a pile of instant film carnage in all directions. You know it was a good party if you're pulling peel-apart film wrapping out of your pockets for the next two days.


text:
European Environment Agency critical of shipping air pollution
The shipping sector has been described as 'one of the most unregulated sources of air pollution'. In a report on shipping, the European Environment Agency (EEA) says emissions from the sector have 'increased substantially' over the last two decades. Nitrogen dioxide and particulate matter (PM2.5) levels have risen by as much as 35-55% between 1990 and 2010, and nitrogen oxide emissions could increase so much in the coming years that they could be equal to land-based sources by 2020.
Antoine Kedzierski
Policy Officer
antoine.kedzierski@transportenvironment.org
Published online earlier this month, The impact of international shipping on European air quality and climate forcingpraises the EU for reducing sulphur emissions, but is highly critical of other pollutants. T&E's policy officer for clean shipping, Antoine Kedzierski, said: 'This is not the first time an authoritative source has said air pollution from shipping needs to be properly addressed, and quickly. The EEA recommends better integration between air pollution and climate change policies. With Commission climate officials working on a proposal on monitoring ship emissions, this is the chance for action on this long-standing problem.'
Ship air pollution