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Developing the Next Generation of Drugs for Dermatological Conditions
Industry Insight Feb 07, 2020 | By Laura Elizabeth Lansdowne, Senior Science Writer, Technology Networks
Laura Elizabeth Lansdowne
Senior Science Writer
The World Health Organization states that dermatological (or skin) diseases are amongst the most common of all human health afflictions, affecting approximately 900 million people worldwide at any one time. With so many people impacted, there is a clear need to develop novel therapeutics with the best efficacy and safety profiles as possible.
We recently spoke with Robb Knie, CEO of Hoth Therapeutics to learn more about the company's mission, drug development pipeline, and the various dermatological conditions they are designing therapeutics for.
Laura Lansdowne (LL): For some of our readers less familiar with Hoth Therapeutics, could you tell us a little about the company mission and history?
Robb Knie (RK): Hoth Therapeutics is a publicly listed biopharmaceutical company trading under the stock symbol "HOTH" on the NASDAQ. The company is dedicated to developing and bringing new generation therapies to patients suffering from dermatological disorders. Hoth first started to develop its leading therapeutic platform to eradicate Staphylococcus aureus or S. aureus in the skin at the University of Cincinnati. One of our leading scientific advisors, Dr Andrew Herr, led this research and achieved positive results at the preclinical stage conducted at the University of Miami. Since then, the company has developed a strong intellectual property portfolio through exclusive collaborations with various universities to treat skin conditions including atopic dermatitis, chronic wounds, psoriasis and acne. Hoth recently completed a 28-day animal toxicology study in which initial data showed all animals were in good condition with no adverse safety effects. The company is planning a clinical trial in humans later in 2020.
LL: Can you tell us about the indications you are developing therapeutics for?
RK: Hoth's pipeline currently contains clinical-stage treatments for dermatological conditions with product candidates in various stages of clinical development with exclusive licenses to patents and trademarks. Current therapies include BioLexa, VNLG-152, Z-Pods, aprepitant and genetic markers for food allergies & eczema.
The BioLexa Platform is a proprietary, patented antimicrobial therapy, targeting atopic dermatitis (AD) or eczema and chronic diabetic ulcers. The platform is based on cutting-edge scientific research from University of Cincinnati.
VNLG-152: Licensed from the University of Maryland, VNLG-152 targets psoriasis and acne by providing a unique approach to achieving the therapeutic benefit of retinoid therapy.
Z-Pods: Hoth is co-developing a patented technology delivery system for drugs treating cutaneous lupus erythematosus , a chronic autoimmune disease that affects the skin, by using patented xerogel-derived nanoparticles, called Z-pods™. This topical administration will deliver—in a sustained and controlled manner—notoriously hard-to-deliver therapeutic agents, hence improving therapeutic outcome.
Aprepitant is used to treat skin conditions and other side effects of erlotonib enabling cancer patients to complete their prescribed treatment regimens. Erlotonib is a drug that is used to combat various cancers and has been known to cause varying degrees of skin rashes, lesions, hair loss and nail changes to patients.
Genetic Markers: Hoth holds an exclusive license from the University of Cincinnati to develop a patented technology to determine a person's propensity to suffer an allergic reaction to certain types of food, including; peanut allergy, milk allergy, general food allergy and eczema.
Gene Therapy: Hoth also holds an exclusive license with North Carolina State University (NC State) to lead a preclinical study for the treatment of asthma and allergic inflammation. The goal of the study is to establish proof of principle by targeting the gene encoding the FcεRIβ protein in the lungs of mice and determine the best approach for targeting allergic inflammation in the airways with splice-switching oligonucleotides (SSOs).
LL: Why did you decide to focus on these indications?
RK: We found current treatments addressing these indications to be costly and ineffective particularly for our target patient population, adolescents. For example, approximately 32 million Americans suffer from AD a chronic skin condition characterized by staphylococcal colonization and biofilm formation, which represent a market opportunity for Hoth of $9.5 billion. In the US, approximately 10 to 13% of all children and 7 to 8% of adults are impacted by AD. In the current marketplace, treatments maintain rather than cure these indications through invasive, costly and topical treatments that frequently cause side effects. Hoth is working to address this unmet need to develop remedies that alleviate these conditions with minimal to no side effects, addressing a major quality of life issue for patients suffering from several dermatological disorders. Initial data shows that our leading asset platform, BioLexa, will be able to treat other staphylococcal infections triggered by post-surgical procedures such as laser skin resurfacing, cosmetic surgery, skin cancer excisions, among others.
LL: What is the BioLexa Platform™, how does it work?
RK: The BioLexa Platform, Hoth's lead drug candidate platform, is a novel mixture of two FDA approved compounds targeting AD or eczema and chronic diabetic ulcers. The first compound breaks down the biofilm protecting the bacteria (S. aureus), allowing the second, an antibiotic, to more effectively treat the underlying infection.
First Indication: Atopic Dermatitis
Hoth is developing a patented topical non-corticosteroid approach inhibiting the formation of biofilms. Following a successful first clinical trial, investigators plan to begin human trials during the first quarter of 2020 in Australia.
Second Indication: Chronic Diabetic Ulcers
This treatment also inhibits the formation biofilms. In preclinical studies, Hoth reported positive results from a pilot animal study conducted under a Scientific Research Agreement with Massachusetts General Hospital Vaccine and Immunotherapy Center ("MGH") to test the inhibition of the formation of S. aureus biofilms in diabetic foot ulcers and chronic wounds. The findings reported majority of the treated wounds were fully closed and re-epithelialized, with better collagen deposition and increased angiogenesis.
LL: What can we expect to see from Hoth Therapeutics in 2020?
RK: We remain focused on continuing to invest in developing our current pipeline therapies, while broadening our research across various dermatological indications. Now that we have completed our animal toxicology study for BioLexa, we are preparing for our first in human trial in Australia this year targeting the adolescent patient population. Our current plan is for treatment of 10 healthy patients in a Phase IB, which will roll us into 60–80 adolescent patients with mild to moderate atopic dermatitis aged 2 to 17 years old. We are currently targeting to receive top-line data during the second half of 2020.
Robb Knie was speaking to Laura Elizabeth Lansdowne, Senior Science Writer for Technology Networks.
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Mastercard and Visa cards are accepted in any of our stores. Should you wish to do an online purchase, please fax or e-mail us written consent to debit your card.
If you do not have a credit card or do not prefer to use one, send us an order by e-mail or fax.
Bank transfers or deposits are welcome. Please use invoice number as reference when making payment. Goods will be released or sent as soon as payment reflects on the bank statement.
We strive to give you the fastest service possible. Normally, orders received before noon will be shipped by noon the next day, after payment clearance has been received. Special arrow or string orders might delay shipping slightly. We will either ship with Speed Services via the Post Office or Courier of your choice. Please specify what will be most convenient for you. If the parcel was sent via speed services, then the parcel will have to be collected at the post office unless arrangements have been made for door-to-door delivery. Items that are not claimed by the buyer from the Post Office will be returned to us and postage for re-shipment will be the liability for that of the buyer. Postage is the responsibility of the buyer unless stated otherwise.All parcels will be insured (cost of 1.5% of value) and is for the cost of the buyer. The buyer should not accept damaged parcels until the transportation company agent has noted the damage on the waybill. Please DO NOT RETURN THE DAMAGED GOODS TO US. Magnum Archery cannot be held responsible for any loss or damage to goods via Post office or Courier Company. As mentioned before, we will automatically insure the shipment to reduce the financial risk of damage or loss of the shipment. If however you prefer to accept the risk of damage or loss of the parcel during shipment, you can exercise the option not to insure by letting us know in writing. In the case of the loss of the shipment you will however be liable to pay Magnum Archery for the shipment not received since it was sent as per your instruction. Magnum Archery's responsibilities end once the parcel has been sent or collected by the courier company. No shipping will be done if account is overdue or previous invoice is not paid in full.
In the case of Speed Services, the typical order will be delivered the next day or two if payment has been received before 10:00 the previous day and if credit card approval is obtained from the bank and no arrows needs to be fletched or any special work needs to be done for you.
The Post Office parcel post usually takes 5 to 7 days for delivery in South Africa. You will be informed on the day of shipment and receive the tracking number of you parcel.
We are not undertaking international sales at this stage due to quotes required for international shipping cost. Customers are welcome to fax us their orders for quotes that will include the correct shipping cost.
Defective Merchandise and warranty items.
Defective or warranty merchandise is repaired or replace by the manufacturer. Merchandise must be returned directly to the respective manufacturer except for bows that will be handled by us. We will supply you with the address and phone number, and any assistance you may need.
For bow warranty, please e-mail us the following information on magnumpta@plotnet.net.
photo of defect and description of product or what happened.
Once this has been received, then the necessary steps can be taken to obtain a warranty. You will be informed about the progress, and the warranty can only be done once ALL information has been received.
Magnum Archery will not do any warranty claims without proof of purchase or invoice. Any shipping costs and clearing fees to get the warranty fixed will be that of the customer.
Post Office insurance cost at 2% of shipment value with a limit of R5000.
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LotFP: RPG: Green Devil Face and Random Esoteric Creature Generator... reviews!
Green Devil Face and Random Esoteric Creature Generator... reviews!
Also a review of the Creature Generator has been posted at that new Geekdō site.


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Mayoral candidates respond to LCC's cycling manifesto: Lindsey German, Left List
By London Cycling Campaign on at 11:00pm 12 April 2008
Following on from our mayoral elections piece in the current issue of our members' magazine London Cyclist, which features responses to LCC's cycling manifesto from Ken Livingstone, Boris Johnson, Sian Berry and Brian Paddick, LCC has invited all mayoral candidates to send us their responses to our 10 point plan to transform cycling in London.
The London Cyclist article can be downloaded using the link on the right.
We'll publish candidates' responses as we receive them – keep checking back for updates.
Lindsey German, Left List
1. Make 20mph the standard speed limit on London's streets to reduce road danger and encourage cycling and walking.
"Agreed, but this needs to be part of an overall reassessment of our transport system. If the average commuter speed is 9mph, it's hardly surprising that car drivers drive much faster than 20mph when they have an opportunity to. Among other things, this requires adequate investment in public transport."
2. Make reducing road traffic crime a London-wide policing priority because these crimes lead to the most injuries and deaths.
"It is a travesty that far more people are killed and injured on our roads than by other threats - including terrorism, but this is not reflected in political or policing priorities. As well as the investment in public transport suggested above, this requires a cultural re-education, not just more policing. The culture of car driving - from the manufacturers' adverts to Jeremy Clarkson - is macho, crass and speed obsessed. A disproportionate amount of accidents involve young drivers who have never been taught to drive responsibly, for whom driving recklessly can be an escape from boredom or low self-esteem. They have certainly never been taught to take cyclists into account and a diminishing number have ever learned how to ride a bike properly, which in itself would improve road safety. This all needs to change if we are to have safer roads."
3. Deliver free on-road cycle training for London's children, subsidised training for adults of all abilities and compulsory training for highway engineers and transport planners.
"Agreed, but with a recognition that people will not take up cycling in significant numbers until they feel safe. Cycling experience should also be included in the driving test."
4. Return one-way systems and streets to two-way operation and create advantages for cycling and walking, thus maximising route choice and minimising diversion. Provide means and incentives for boroughs to support this shift.
"Agreed. Far more road priority should be given to cyclists and pedestrians, but again, this requires a cultural shift. Other countries manage it - there's no reason why we can't."
5. Ensure high-standard cycle parking is available at every workplace, station and shopping area, as well as in all new homes.
"Agreed, but also make sure they are decent cycle parks that actually work easily, rather than looking fancy. Keep cycle stands simple!"
6. Ensure the budget for the completion of the London Cycle Network Plus (LCN+) to a high standard in all 33 boroughs with effective removal of all barriers and the creation of strong network links between boroughs.
"Agreed. As with cycle parking, cycle paths need to really encourage cyclists by being effective. A bad cycle path is worse than none at all. As with question 4 above, cyclists and pedestrians need to have priority and cycle paths must not be subservient to roads."
7. Adopt ambitious targets to encourage walking and cycling to all events and attractions supported by the Mayor, culminating in the first 'active spectator' Olympics in 2012.
"It would be good to think this could happen, but the recent report of Olympic bureaucrats 'needing' chauffeur driven limousines doesn't inspire confidence. The Olympics present a brilliant opportunity, not least to encourage cycling on the back of the success of our cyclists at the recent track world championships - but this can only happen if cycling is seen as part of the transport mainstream, not a minority activity. Ken Livingstone should set an example. He should just ban cars from the Olympic park. Make the blazers and politicians walk or cycle!"
8. Create a Paris-style mass cycle hire scheme by 2009 and include all Olympic venues by 2012.
"Agreed."
9. Start a major campaign of action against cycle theft including a significant theft reduction target for the Metropolitan Police in every borough.
"Agreed. Experience in Tower Hamlets suggests that such a concerted approach does bring results."
10. Produce a tube-style map showing strategically important and family friendly cycle routes to encourage Londoners to think of cycling as an everyday mode of transport.

redpajama_set_name: RedPajamaCommonCrawl


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British Council Film Collection
Back to the Collection
The People's Land
Like This? Try This...
Gardens of England
The Green Girdle
Architects of England
A Technicolor guide to some of the coastline, countryside, and properties preserved by the National Trust.
Ralph Keene
Strand Film
Ralph Vaughan Williams
Frederick Grisewood
Al Rhind
Muir Mathieson
Running time (minutes)
Music Played by
Musicians led by
George Stratton
The Properties of the National Trust
'A film of National Trust properties of beauty and historic interest, preserved for the people. They include prehistoric stone circles, ancient castles like fourteenth-century Bodiam, a Chiltern village, stretches of the Sussex downs, the famous valley of Dovedale, 14000 acres of lovely country in Westmorland. This noble heritage is held in public trust - for ever.'
(Films of Britain - British Council Film Department Catalogue - 1947-50)
Identified locations in this film include:
The White Cliffs of Dover; St Andrew's Church, Alfriston, East Sussex; Bodiam Castle, East Sussex; The Bridgewater Monument, Ashridge Park; Little Moreton Hall, Cheshire; West Wycombe, Buckinghamshire; Dovedale Valley, Derbyshire.
The church that features at the 1-minute mark is St Andrew's Church in Alfriston, East Sussex. This church also appears in the background of a scene in the British Council film Make Fruitful the Land. Though the church is not owned by the National Trust, the attached Alfriston Clergy House (not shown in the film) was the first property to be acquired by the organisation.
When this film was first made, it had a different (unknown) narrator. The British Council were unhappy with them, however, and decided to have a new commentary recorded by a "more verily commentator", ultimately choosing BBC broadcaster Freddie Grisewood.
Click below - or on the link on the right for a transcript of the film
English Voiceover
This is England. It's a small island but it has some of the loveliest country and some of the prettiest villages. And some of the largest, ugliest, and most vigorous cities in the world.
In many countries, the need to preserve natural beauty and noble surroundings has been recognised by the state. In England, they have been saved by the people.
In 1895, without assistance from the government, a number of private enthusiasts formed The National Trust, dedicated to this work. The fruits of their idealism are more than ever welcome today, when the cares of daily life lead more and more people to spend their leisure away from the cities in the peace of the countryside.
This great stone circle beneath mighty Helvellyn in the Lake District was set up in adoration in strange, forgotten gods.
And magnificent Bodiam Castle was built in the 14th century by one of the Black Prince's knights as a comfortable residence which could yet house a community in times of siege.
Little Moreton Hall – a famous example of Cheshire black and white architecture – is still lived in by the family who built it in the days of Queen Elizabeth.
Here in the mountains of Westmoreland is a farm typical of the district. The Trust is an easy landlord to farmers and encourages good husbandry on its farmlands.
West Wycombe in the Chilterns is one of several villages owned and protected in their entirety by the Trust.
Over a thousand places and over a 150,000 acres of England are held in public trust forever, as every kind of country from high moorlands to rolling downs, and every kind of homestead, from splendid castles to humble cottages. Many estates were presented by their owners; others were purchased by donations from many small contributors.
To the children, the open country holds a magic promise of adventure. In the fresh air and sunlight beyond the ancient lanes they can play in a world of their own.
Dovedale, in the heart of England, lies near mining towns and centres of the cotton and pottery industries, whose people flock in their thousands every year to explore this lovely valley and its great pinnacles of limestone.
Nine-hundred years ago, the Norman invaders found much of the east of England like this fen land in Wycombe. Today, hardly changed, it is still bright with flowers, the haunt of birds, moths, and butterflies.
Here is England's lakeland. The countryside that Wordsworth loved. Small wonder that its islands and gleaming waters inspired some of the country's greatest national poetry.
People come over these hills from far away, down long the slopes, through Langdale, to the Pikes, past Friar's Crag, up Birch Crag Borrowdale, over the pass to Crummock Water.
The climbers, the children, and the fishermen, they come from the crowded cities to refresh their spirits. The land that welcomes them is administered by the Trust, but the people are its guardians. For the unspoiled beauty of this rich heritage of Britain, defended against every foe by the hearts and hands of their forebears, is still the responsibility of the people.
Download this film
(right click and Save Link As)
MP4 File
People's Land Feedback - Malta
The People's Land Transcript


The word transcendence means "to go beyond" The aim of this modality is to support individuals in moving beyond ideas and concepts around being one's true and authentic being. Cultivating a deep awareness and trust so that we can stand in the brilliance of who we are right now.
Transcendental Therapy includes intuitive counseling, flower essences and a variety of subtle healing modalities to support each individual in being fully equipped to live their best life regardless of any circumstance, here and now.


text:
Trump Slams Twitter 'Bias': 'Removed People From My Account'
President Donald Trump took on the social media outlet that he dominates, slamming Twitter Friday. His regular tweeting has been a huge boost to the site, but he accused it of removing followers and limiting the growth of his account.
On October 26, Trump tweeted, "Twitter has removed many people from my account and, more importantly, they have seemingly done something that makes it much harder to join – they have stifled growth to a point where it is obvious to all. A few weeks ago it was a Rocket Ship, now it is a Blimp! Total Bias?"
The president's social media following on Twitter had skyrocketed after his election in 2016, growing from 13 million followers to 51 million in 17 months. From November 2016 to May 2018, the president gained roughly 2.2 million followers a month. From May to October 2018, however, the president was only gaining between 600,000 and 700,000 followers a month.
Former Arkansas Gov. Mike Huckabee tweeted that he was having similar problems, saying: "Same thing has happened to my account. It is NOT accidental or honest on Twitter's part. They are intentionally throttling voices that are not in liberal lockstep. Time for Congress to investigate!"
Twitter has been heavily criticized for bias against the right. It was the subject of a hearing held by the Energy and Commerce Committee in Congress on September 5. CEO Jack Dorsey denied any bias towards conservatives, and further denied any planned censorship of conservatives on his platform.
Twitter has banned, suspended, and removed many conservative or pro-Trump users' accounts in the past six months. It did all this while allowing anti-Semitic statements from the Nation of Islam leader Rev. Louis Farrakhan and promoted tweets about female genital mutilation to remain.
Conspiracy theorist Alex Jones was completely removed from Twitter, as were several other Infowars accounts. But conservatives like actor James Woods, Benghazi hero Kris Paranto, libertarian candidate Austin Petersen, and pundit GayPatriot have all been suspended (or in GayPatriot's case, banned) from Twitter.
On October 25, Twitter announced it lost 9 million users in the past quarter. This was 4 million more than expected, according to the firm. The user drop, apparently, was due to the company "clamping down on accounts that disseminate spam or use automated bots to try to target legitimate users." While Twitter apparently has 326 million active users, according to Fortune, 9 million is about 2 percent of Twitter's base.
Twitter responded on Friday, October 26, "Our focus is on the health of the service, and that includes work to remove fake accounts to prevent malicious behavior. Many prominent accounts have seen follower counts drop, but the result is higher confidence that the followers they have are real, engaged people."
This article was originally published by Newsbusters.org. Read the original article here.
← Scientists discover an itty bitty octopus floating on a pile of plastic trash
The 5-point iPhone XR review: How Apple walks the fine line of greatness →
CNN, MSNBC Give Liberals Forum to Push Gun Control Myths
March 2, 2019 ENR 0
Google, Soros Fund Facebook's New Fact Checkers
January 13, 2019 ENR 0
Facebook and Instagram Won't Ban Violent Antifa Group
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That's the motto KCHA and KCZE is built upon. A foundation created to produce content that matters by engaging our listeners to news, sports and topics that fall upon your ears each and every day.
In order to raise the standard of journalism daily, we are creating new programs to the airwaves starting next week. Whether you live in Charles City, New Hampton or any of the surrounding communities, our goal is to connect with you on a daily basis.
Next week, Kellan Heavican will be hosting the noon hour LIVE on 95.9 and 1580/103.3. The Lunchtime Traffic Jam will feature a host of new programs and continue ones already on the air.
In addition to the live, local news, the local and area sports update will be The Afternoon Scoresheet. We'll bring you the same sports updates, but better than before. We'll continue state news and sports with Radio Iowa and local producers and agriculture enthusiasts will still be able to stay in touch with the latest markets with the Brownfield Midday Commodities.
Oh, and we can't forget to get you your latest weather forecasts.
Both KCHA and KCZE will be featuring the Community Conversation. Kellan be talking with city leaders from surrounding communities about the latest happenings. In addition, we'll be talking with our local school districts about what's happening in education.
The last segment, let's just say, is a surprise for you.
This all starts next Monday LIVE. We can't wait for you to join us.
The addition of the FM feed allows us to reach more of you. We're increasing our sports coverage this fall too. For the first time ever, our Fab Oldies 1580 and 103.3 will be bring you the Game of the Week. Right now, we're covering four weeks of Iowa high school football.
We're working closely with our high schools in town to let the students and faculty to bring you the news.
The Charles City and New Hampton FFA programs are creating a weekly ag program. It will provide the latest ag news, markets and have other unique segments that are sure to connect you with the things that matter the most.
Students and staff will be on air weekly providing school updates and showcasing their talents in all departments across school.
Don't worry- Erik Hoefer's Comet Connection will still air Saturday mornings from 8-10.
In an always-changing media landscape where small radio stations are being bought up by national media conglomerates, we are proud to be locally owned and operated.
Small town radio is alive-and-well in Northeast Iowa.
Always local, always serving you and always connecting you. We can't wait join you for all of our new programming starting next week.
If you haven't already, download the KCHA, Fabulous 1580 and 95.1 The Bull app. Or find us online at www.kchanews.com or www.951thebull.com and you can hear your favorite station anywhere in the world.


text:
Q: Uploading image to backend I can not get image upload to my restAPI server via http package. I spend whole day looking for an answer and didn't find any. My backend require an actually image but I don't seems to manage it with http package.
  Future<void> createProfile(Profile profile) async {
    try {
      var request =
          new http.MultipartRequest("POST", Uri.parse(APIPath.createProfile()));
      request.fields.addAll(profile.toMap());
      request.files.add(await http.MultipartFile.fromPath(
          'image', profile.image.path,
          contentType: MediaType('image', '*')));
      request.headers['authorization'] = "Bearer $_token";
      final response = await request.send();
      if (response.statusCode == 200) print('Uploaded!');

      notifyListeners();
    } catch (error) {
      throw error;
    }
  }

My backend is written in node.js and was tested in postman so backend should be fine. However when I tried to upload an image from my front end it gives me error only images allowed which means the image doesn't get to the server(allowed image type is correct). Please any help appreciated
error triggered in Node.js
const fileFilter = (req, file, cb) => {
   if (file.mimetype === 'image/png' || file.mimetype === 'image/gif' || file.mimetype === 'image/jpg' || file.mimetype === 'image/jpeg') {
      cb(null, true);
   } else {
      const error = new Error('Only images are allowed')
      error.statusCode = 406;
      cb(error);
   }
}

A: That because contentType: MediaType('image', '*') will resulted as image/*, which did not matched with the file.mimetype in node.js.

A:  uri = Uri.parse(url);

 var request = new MultipartRequest("PUT", uri);

 var multipartFile = await MultipartFile.fromPath("package", path);

 //path = filepath

 request.files.add(multipartFile);

 StreamedResponse response = await request.send();

 return response;

redpajama_set_name: RedPajamaStackExchange


Did H.G. Wells do a better job predicting the future of warfare than the Pentagon?
H.G. Wells gave us many of our most beloved science fiction conceits — but did he also foresee how war would develop in the era of airplanes and advanced weaponry? And were his predictions more prescient than some of the Pentagon's attempts to forecast the changing nature of war have been?
That's the conclusion reached by Micah Zenko, a fellow at the Council on Foreign Relations, in an article posted over at the Atlantic Monthly. Zenko runs down many of Wells' predictions for the future of war, including more intricate types of rifles, and bomber planes. Unfortunately, not all of Wells' predictions were on the money — he predicted that citizens would all serve in the military, and that civilian casualties would be low.


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White Sox SP Chris Sale Rumored To Skip A Start, Don Cooper Refutes Report
By Steve von Horn Aug 23, 2012, 10:58am CDT
Share All sharing options for: White Sox SP Chris Sale Rumored To Skip A Start, Don Cooper Refutes Report
Chicago White Sox starting pitcher Chris Sale has been dominating hitters for most of the season with his hard slider and funky delivery, and with the team in the thick of a playoff race Don Cooper isn't ready to talk about innings limits or pitch counts right now. Sale has a violent delivery that is called the "inverted-W," and earlier in the year he was shut down by the club for a short stint with something the team called "elbow tenderness." Bruce Levine of ESPNChicago.com has sources telling him the Sox will skip one of Sale's starts over the remainder of the regular season, but Cooper has refuted that report, telling Jon Greenberg: "As far as I'm concerned, he's got eight more starts left."
Cooper also refused to give any credence to the notion that the White Sox have imposed a hard innings cap or strict pitch count on Sale -- which is something the Washington Nationals have publicly implemented with star hurler Stephen Strasburg. Here is what Cooper had to say about the possibility of a hard innings cap being placed on Sale:
..."I'm not speaking for the organization, but I'm not going to use a number. We're going to use our eyes, we're going to use our gut, and we're going to use everything that we see and all of our instincts to make a decision on guys. We're in the heat of it here and we're trying to win a pennant. They don't want to be pulled and we don't want to pull them, but we're going to watch them."
Sale has posted a 2.65 ERA and a 15-4 record over 22 starts and 153.0 innings during 2012, and he figures to factor into the AL Cy Young race when voting rolls around.
For more in-depth coverage of the White Sox, visit White Sox blog South Side Sox. For more news, notes and analysis from around baseball, head over to Baseball Nation.
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King County Superior Court's Partnership for Youth Justice, is seeking volunteers from the Bothell/Kenmore area to serve on a community accountability board (CAB).
According to a press release, the function of the board is to determine consequences for minor juvenile offenders in their community. The key role of the CAB as a community service is to balance the needs of victims, communities and offenders. The goal is to restore each of the parties, as fully as possible, from the effects of crime. The program offers an alternative to the formal juvenile justice system by diverting those youth to their community for an informal hearing.
CAB volunteer requirements include at least a one-year commitment, completion of training, two hours a month participation and a non-judgmental attitude toward youth. Hearings are held in the evenings.
For more information call 206-296-1133, email Shirley.Noble@kingcounty.gov or visit kingcounty.gov/courts/juvenilecourt/diversion.


Need to find the ideal way to get in touch with a Toyota dealership in Alexandria, IN? Look for important contact details, opening hours, and more right here.
Local Toyota dealers offer quality financing options for new and high quality used Toyota trucks along with certified Toyota vehicle maintenance service.
Unsure of which RAV4 trim is right for you? Schedule a test drive today to explore all of the great options available at your nearby neighborhood Toyota dealership.
Search for new and used vehicles at your local Toyota dealer today to test drive the ideal Toyota for you.
Even if this is your first time buying a car, trust your community Toyota dealerships to bring you through the car leasing process and paperwork, without hassle.
With a selection ranging from sports cars to compact cars, you can trust your area's Toyota dealer to help you find the ideal Toyota for your lifestyle.
Know you can trust your area's Toyota dealers to provide you with the service and professionalism you've grown to expect.


Thank you very much for giving me the opportunity to travel to Driffield. I gained invaluable life experiences that I would never have been able to without your assistance.
The social side of the club and living in Driffield was fantastic. One night at the club which I particularly enjoyed was Driffield's got talent (which Damo, myself and a couple of the lads won).
The community atmosphere at the club was great. We had dinner with the team after each training session and game. Everyone was amazingly hospitable and the generosity shown to me by everyone, especially Andrew Kitching and Andrew Chapman, really made me feel like a part of the community.
The "lads" were great and I made some very good friends in my time there. The house Damo and I lived in was always full of the rugby boys and we had some great times there.
Although weather and injury limited the amount of rugby I played, I really enjoyed the games I did play. The style of rugby was very different. They play a much slower, forwards oriented game and it was a great experience to play a different way to what I am used to as well as to be introduced to mens rugby.
Playing in freezing conditions is something very different to what I'm used to as well. The last game I played, the field was covered in snow!
The away games were also a great opportunity to see different parts of England and I was lucky enough to do a bit of travelling while I was there, going to Paris, Edinburgh, London and York.
My time in Driffield was a unique once in a lifetime experience which I would never have had been afforded without the generosity of Harry Peters, Andrew Kitching, Southern Districts and Driffield Rugby Club.
Thank you very much for making this trip happen.


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In Support of My Candidacy in NC's 14th general convention
Published On: December 2, 2021 08:15 AM NPT By: Prakash Pokhrel
Prakash Pokhrel
The contributor for Republica.
news@myrepublica.com
Unbreakable Nepal-India Relationship: Why Cracks Occur?
Nepal's Failed Governance and Unemployment Problem
It is certain that the organization of the NC will be weakened if the mature leaders do not get the opportunity during the formation of the provincial committees. Only the experience of mature leaders and the ability and activism of young leaders can make the NC strong.
Despite repeated confusions, the 14th General Convention of the Nepali Congress (NC) is finally going to be held this Month. With the date of the session fixed, new enthusiasm has spread among the NC cadres and supporters.
As the aspirations for leadership positions have been on the rise since the ward level session, it can be assumed that the people's trust in the NC is increasing, but the background of the majority in the leadership positions suggests that loyalty and ideals within the party are waning. Concerns are rife within the NC that money and Muscle are gaining ground. When it comes to ward, city, region and district level sessions, the cadres seem to be worried as extreme factionalism is growing within the party. It is not in the interest of the NC to take the lead in a factional way that affects the voters. It is certainly not in the interest of the party to restrict the natural right of the representative to freely select the leadership. The party organization is getting weaker day by day due to the struggle to make oneself strong within the party.
For the first time in the history of the Nepali Congress, new leadership is being selected in all the seven provinces according to the federal structure. It is almost certain that the aspirants will take the field for the leadership of the provinces in a group, but since the attitude of most of the provincial general convention delegates is that there should be better leadership than ours. It is necessary for the central leadership to be prudent in selecting candidates. The outcome of the provincial sessions will have a direct impact on the central convention as well.
Neighboring nations are also watching the Nepali Congress' General Convention with interest. Interacting with Indian leaders, the self-proclaimed pundits seem to have a special interest in the NC leadership, mainly in Province 2 and Lumbini Province. Therefore, the leadership of Lumbini Province is of special importance in the politics of the NC. Neighboring India has a different interest in the geography from Nawalparasi to Bardiya, so it is important for the NC leadership to be strong and effective.
I am myself trying to use my 30 years of political experience with the NC to play a responsible role in building the party organization in Lumbini Province. It is certain that the organization of the NC will be weakened if the mature leaders do not get the opportunity during the formation of the provincial committees. Only the experience of mature leaders and the ability and activism of young leaders can make the NC strong. In consultation with some of the senior leaders of the NC's central leadership, intellectuals and delegates elected for Lumbini, including the General Convention delegates, I am trying to establish myself as the Joint General Secretary for Lumbini. It is necessary to develop a culture of evaluation on the basis of contribution and capacity in the party. Observing the village to district level sessions, it was seen that there was an attempt to stop the potential leaders from the grassroots in various ways. Such a culture cannot nurture the organization of the NC. When one finger is shown to others, four fingers are turned towards oneself. I aim to give a strong impetus to the NC organization in Lumbini Province and build a strong organization that can get the Nepali Congress elected with a majority in the local, provincial and federal elections within the province. Surviving the long wave of treatment in the ICU at Medicity Hospital during the second wave of Covid, with this new life, I seek to move forward with a commitment to the country and the people. While claiming for the post of General Secretary, it seems relevant to present some grounds.
1: After the then King Gyanendra took over, voices against the King's move were recorded and broadcast in the international media by the top leaders including the NC president who was under house arrest. By presenting the underground leaders in the international media, the King was forced to back down from his regressive steps. During this period, I had to be deported to India for some time after receiving death threats from reactionary groups. I also had to live underground even while being in Nepal. If democracy had not been restored, it would not have been possible to hold such an open party convention today.
2: In order to establish peace in Nepal through various media to create pressure among the international community to internationalize the voice of the people affected by the Maoists and the national army some 18 years back, I was beaten too and my right ear still has hearing issues because of the army's beating. Peace has been established in Nepal under the leadership of the Nepali Congress due to an all-round pressure.
3: I was abducted and was kept in captivity by the Maoists in Kapilvastu for protesting against the atrocities against the Nepali Congress activists. Jani Banjade, a student leader close to the Maoists, did not spare my life and even the Maoist extremists ordered to kill me.
4. The pen movement (articles published in national / international newspapers) pressured the government to oust Prime Minister KP Oli, who led the government with a two-thirds majority, as the threat of an attack on the democratic system increased due to his arbitrariness, authoritarianism, fake nationalist character and corruption. The people here are aware of this. As a result, the Nepali Congress now has the opportunity to lead the government.
5: 33 years back, I was leading the Nepal Student Union in Naya Gaon Gulmi and have been actively participating in the people's movement for the restoration of democracy.
6: Due to the panel's mismatch in the 12th / 13th General Convention of the Nepali Congress, I as a candidate for the General Convention was limited.
7. I have been working day and night to strengthen the Nepali Congress organization by writing articles and by attracting the general public to the party through visiting different districts.
8: I have been making special contributions to various fields including ambulance operation, drinking water, irrigation, health, education and tourism in the villages.
9: Being close to the central leadership, I have been assisting the leadership through analytical suggestions of national / international politics.
10. Contributing to maintaining good relations between Nepal and neighboring nations through articles and various private meetings.
11: I am elected as a representative for the upcoming 14th General Convention from Gulmi 2 (b) with a majority of votes.
On the basis of above facts, I would like to make a heartfelt appeal to the province and General Convention representatives, the NC leadership, the intelligentsia, the media and other concerned parties to extend their support in this opportunity to play a role as NC's Joint General Secretary in Lumbini Province.
(The author is a young leader of the Nepali Congress and a political analyst)
Nepali_Congress
14th_general_convention
Complete election results of NC's 14th General Convention by Wednesday
KATHMANDU, Dec 21: The entire election results of the Nepali Congress 14th General Convention are expected to be out by...
NC 14th General Convention: 380 votes cast till 1:30 PM
KATHMANDU, Dec 13: A total of 380 votes were cast till 1:30 pm in the ongoing voting process of the...
52 central members, one joint-general secretary, one presidential candidates withdraw nomination
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UML Secy Bhattarai urges PM Deuba to relieve Minister Renu Yadav from her post
Govt bans travel to Gulf countries, Malaysia on visit visa


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Flexing our SD-WAN muscle: from industry-leading MEF representation and analyst recognition to customer validation and trust
August 22, 2019 Franck Morales , News
I just had the privilege of being appointed Advisory Director to the prestigious MEF 2019-2020 Board of Directors, on behalf of Orange Business Services. MEF is driving agile, assured and secure communications essential to digital transformation.
As part of the MEF Board, I will be responsible for accelerating the adoption of MEF 3.0 services that provide the dynamic performance and security essential for enterprises to succeed in the digital economy. MEF 3.0 is a Transformational Global Services Framework for defining, delivering and certifying assured communications services orchestrated across a global ecosystem of automated networks.
MEF's ground-breaking work in standardizing the SD-WAN service is addressing one of the biggest challenges to SD-WAN service market growth: the lack of an industry standard service definition. Together, our work will help to accelerate the take-up of SD-WAN products and services, which for us, is already on an upward curve.
The Orange Business Services march in the SD-WAN market has been noted by analysts and customers alike. Only recently, we were recognized as a Leader in the IDC MarketScape: Worldwide Communication Service Provider SD-WAN Managed Services 2018 Vendor Assessment. This comes on the back of the recent launch of our Flexible SD-WAN offering, which is already being deployed just in the past year by major customers, including Sony, Aurecon, Majid Al Futtaim Retail and Weener Plastics.
We were also highlighted in Avasant's SD-WAN Managed Services RadarView 2019 as a leader in SD-WAN Managed Services for Flexible SD-WAN. The RadarView report assesses providers across three critical areas: practice maturity, partnership ecosystem and investment and innovation.
Nearly 20% of the Global 2000 companies have already adopted some form of SD-WAN technology. Within the next 36 months, enterprise SD-WAN adoption is likely to double, according to Avasant's research.
The proof of an SD-WAN growth momentum is in our recent stand-out deals. Orange Business Services was chosen by Sony Group to consolidate and transform the communication infrastructure of two of its largest operating companies. Built on Orange Flexible SD-WAN, the new Sony network will connect more than 500 locations in over 50 countries across five continents to deliver improved performance, security and scalability to its operations. Orange Flexible SD-WAN will enable Sony to share IT talent and have complete end-to-end visibility for improved global service agility.
I am proud that Flexible SD-WAN is now the Orange Business Services flagship solution in this arena and that it has fast developed a global footprint. And I am equally proud that our industry ecosystem recognizes our growth and strength in this space as well.
Please join me at MEF 2019 in Los Angeles, November 18th to 22nd, where I will have the pleasure of delivering an executive presentation on November 19th. For more details about the event, see the MEF 2019 website.
Article #02: Orange and Nokia set a world first for SD-WAN over 5G
Within the Orange Business Services Connectivity Business Unit, Franck Morales is in charge of developing the portfolio of products and services.
With more than 30 years within the Orange Group (formerly France Telecom), Franck has extensive experience, including 12 years in Mobile Business within Orange France. Franck has spent his entire career with business customers or managing strategic partnerships.
Outside his professional life, Franck enjoys cultural activities such as opera, especially Italian ones, and also loves the theater. Sports also figures in his free time, especially cycling, running and skiing.
SD-WAN: The future is now
Find out how to break free from your global network constraints with SD‑WAN.
Secure, flexible, high-speed connectivity around the globe
Discover more articles and expert insights about SD-WAN.


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Q: How to round datetime()? What I want to do is perform time delta operations but rounding time to deciseconds (I am not sure if the term exists, but the following example should be self explanatory) instead of microseconds.
from datetime import datetime
import time

tick = datetime.now()
time.sleep(1.5)
tock = datetime.now()
time.sleep(2.1)
tock2 = datetime.now()
diff1 = tock-tick
diff2 = tock2-tick
diff1 #0:00:01.500914
diff2 #0:00:03.601836

I would like the diff1 output to be 0:00:01.50, respectively diff2 0:00:03.60. But I do not want to format the result, I want to format the time values I am recording with tick and tock, basically to round them (actually just cut out everything that follows the two digits after the dot). The reason is, at some point in my program I want to compare the two diffs (as rounded time deltas) and only then I want to turn the result into string and format it.
I have tried doing it like this
tick = datetime.now().strftime('%Y-%m-%d %H:%M:%S.%f')[:-4]
time.sleep(1.5)
tock = datetime.now().strftime('%Y-%m-%d %H:%M:%S.%f')[:-4]
diff1 = tock-tick
#TypeError: unsupported operand type(s) for -: 'str' and 'str'

But does not work since it already converts the time to string...

A: You could simply take the total_seconds from the timedelta and round that, constructing a new timedelta:
from datetime import datetime, timedelta
import time

tick = datetime.now()
time.sleep(1.5)
tock = datetime.now()
diff = tock-tick
diff = timedelta(seconds=round(diff.total_seconds(), 2))
print(diff)  # 0:00:01.500000


Cape Town - The Democratic Alliance on Monday called on Gauteng government to devise a plan to avoid public transport disaster should train operations be halted, following the Rail Safety Regulator's (RSR) suspension of the safety permit of the Passenger Rail Agency of South Africa's (Prasa).
The suspension follows last week's collision between two trains at Riebeek Park station in Kempton Park, Johannesburg, which left over 300 people injured. However, trains were still moving on Monday as Prasa's legal challenge to the suspension was before the courts.
The Pretoria High Court has postponed the matter until Thursday.
DA's premier candidate for Gauteng, Tshwane mayor Solly Msimanga, said "this could be an economic disaster for Gauteng as thousands of workers will not be able to go to work until train safety conditions have been improved.
He pointed out through that the forced cessation of train operations by Metrorail in Gauteng would leave tens of thousands of commuters stranded.
"Should train operations be halted it is unlikely that other forms of public transport will be able to handle the additional demand for transport services.
This means that commuters will either be left stranded or will wait for hours for public transport," he said.


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Band and Album Info
Different Orbits is the propulsive debut album from J-Sonics, the six-piece collective who have emerged in the last two years as one of London's hottest groove-driven jazz bands. Set for release on LYTE Records this November, the album brings together a fiery sax-trumpet front line that's fuelled by imaginative guitar work, and a powerhouse bass, drums and percussion rhythm section. J-Sonics push the energy out front and have built a formidable reputation as a compelling live act through sold-out appearances at prestigious London venues such as 606 Club, Pizza Express Jazz Club, Hideaway and Spice of Life as well as a storming appearances at the 2014 Love Supreme Jazz Festival, 2015 London Latin Jazz Festival and three appearances at the EFG London Jazz Festival.
Led by bass guitarist and composer Mike Flynn, J-Sonics features some of London's finest musicians - all solo artists in their own right - but all collaborating within J-Sonics' exciting mix of memorable originals and re-tooled jazz, Brazilian, Afro and rare-groove tunes. Led by the powerful twin-horn attack of saxophonist Matt Telfer and trumpeter Andy Davies, alongside guitarist and composer Clement Regert, drummer Gabor Dornyei and powerful percussionist Jon Newey.
Different Orbits was recorded in a single weekend, live and direct in Wax Studios in Dalston, and bottles some of the unique chemistry that has made this band such a hit on the live circuit. The dynamic ten-track album dives through a vibrant blend of street-funk, Brazilian and Afrobeat songs all shot through with captivating jazz solos, fluid improvisation and a ton of memorable melodies. Originals include cool strutting opener 'Push', the stirring Afro grooves of 'Sing Your Own Anthem' and '12 Labours', the twists and turns of 'Little Ben' and slamming closer 'J-Sonics Theme'. There's a sophisticated slice of soulful jazz funk too that morphs into a Latin-jazz burn up on the vocal-led single 'Samba House', one of three tunes to feature stunning London-based Spanish singer Grace Rodson. Her sublimely soulful vocals also feature on the thumping Brazilian-funk classic 'Partido Alto', (with a brilliant soprano sax solo from Telfer), and funky Ed Motta favourite 'Bananeira'. Other choice covers include an electric Miles-ish take on 'Mr Clean' with scorching bass, trumpet and drum solos, plus the burning samba of 'Casa Forte'.
Different Orbits is a punchy opening gambit from an exciting genre-hopping jazz collective – combining hook-laden originals and inventive reworkings of timeless gems, all given a distinctively energetic yet virtuosic spin.
With a wide range of collective experience J-Sonics' band members are all hugely respected musicians both as in-demand sidemen and acclaimed solo artists and have worked with numerous leading musicians. Rising star Hungarian drummer Gabor Dornyei is an internationally recognised clinician for Sonor drums and also tours widely with his own Thunder Duo group, while he's also made several world tours with the Michael Jackson Thriller Live! and Rock Of Ages shows. Trumpeter Andy Davies leads the renowned weekly jam session Upstairs at Ronnie Scott's and his own groups Simian's of Swing and Bop Shop, while Matt Telfer's regular monthly Vandoren and Yanagisawa jam nights at The Spice of Life and his own Art Blakey and Wayne Shorter inspired solo projects have put these dynamite horn players at the heart of the London jazz scene. Guitarist Clement Regert's many sessions and gigs with the likes of Liane Carroll and Dennis Rollins along with his critically acclaimed Wild Card group sees him working with some of the UK's finest musicians. Bassist Mike Flynn has worked with many leading jazz, world and funk musicians, while also writes and produces his own music and has released an album on Babel records with singer Paula Rae Gibson. Percussionist Jon Newey was a founding member of England's Glory with whom he recorded two albums. He toured and recorded with Crew, south London jazz funk legends Jabba, the Chris Jagger Band and other session dates. London based Latin-jazz singer-songwriter Grace Rodson (pictured left) is a world-class vocalist with high musical studies in classical and jazz. Originally from Spain, she has performed with Iceland super-star Björk and is currently the lead singer of salsa maestro Roberto Pla & His Latin Ensemble and the Yes!!! Brazil Show in the UK, and has been a regular guest singer with J-Sonics for the last year.
Mike Flynn – Clement Regert – Andy Davies – Matt Telfer – Gabor Dornyei – Jon Newey
© 2015 by J-Sonics Media


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Alexander Zverev defeated Matteo Berrettini in the final, 6–7(8–10), 6–4, 6–3 to win the men's singles tennis title at the 2021 Madrid Open. It was Zverev's fourth Masters 1000 title, his first since Madrid 2018, and his 15th career ATP Tour singles title overall. Berrettini was in contention to become the second Italian to be a Masters 1000 champion.

Novak Djokovic was the reigning champion from when the tournament was last held in 2019, but did not participate.

Following the third-round eliminations of Daniil Medvedev and Stefanos Tsitsipas, respectively, a maiden Masters 1000 singles finalist from the bottom half of the draw was guaranteed; Berrettini went on to become that player.

Seeds
The top eight seeds received a bye into the second round.

Draw

Finals

Top half

Section 1

Section 2

Bottom half

Section 3

Section 4

Qualifying

Seeds

Qualifiers

Lucky loser

Qualifying draw

First qualifier

Second qualifier

Third qualifier

Fourth qualifier

Fifth qualifier

Sixth qualifier

Seventh qualifier

ATP singles main-draw entrants

Seeds
The following are the seeded players. Seedings are based on ATP rankings as of 26 April 2021. Rankings and points before are as of 3 May 2021.

Other entrants
The following players received wildcards into the main draw:
  Carlos Alcaraz
  Pedro Martínez
  Jaume Munar
  Fernando Verdasco

The following players received entry from the qualifying draw:
  Pablo Andújar
  Marco Cecchinato
  Federico Delbonis
  Marcos Giron
  Pierre-Hugues Herbert
  Alexei Popyrin
  Carlos Taberner

The following player received entry as a lucky loser:
  Yoshihito Nishioka

Withdrawals
Before the tournament
  Marin Čilić → replaced by  Tommy Paul
  Borna Ćorić → replaced by  Jérémy Chardy
  Novak Djokovic → replaced by  Alejandro Davidovich Fokina
  Roger Federer → replaced by  Miomir Kecmanović
  David Goffin → replaced by  Lloyd Harris
  Gaël Monfils → replaced by  Guido Pella
  Milos Raonic → replaced by  Yoshihito Nishioka
  Lorenzo Sonego → replaced by  Dominik Koepfer
  Stan Wawrinka → replaced by  Albert Ramos Viñolas

Retirements
  Lloyd Harris
  Guido Pella

References

External links
 Main draw
 Qualifying draw

Men's Singles

redpajama_set_name: RedPajamaWikipedia


text:
Today in Hip-Hop History: Ma$e Drops His 'Harlem World' LP 22 Years Ago
feature, Hip Hop News | Trending Hip Hop Stories, News Exclusives
On this date in Hip-Hop history, Harlem icon Ma$e released his sophomore album Harlem World on the Bad Boy/Arista imprint.
A millennial piece of uptown Hip Hop history post the shooting death of rap giant Big L, Harlem World helped usher in a new era of Hip Hop in Harlem. Prior to this release, Harlem had given birth to Doug E. Fresh, Kool Moe Dee, Kurtis Blow, and Rob Base, but had yet to see an artist with the level of conceited charm coupled with chart-topping hits to back it up that a Bad Boy-backed Ma$e had on this album.
Paving the way for groups like The Diplomats and A$AP Mob, this album was chock full of the opulent content expected from a true Harlem World representative. Along with its luxurious themes, the LP is laced with high energy production and a star-studded cast of guest appearances from some of New York's finest, including labelmates The LOX, DMX, Lil' Kim, Jay-Z, Total, 112 and Busta Rhymes.
After the untimely passing of the Notorious B.I.G., this album was set up to be the debut of Diddy's "new protege and although it obviously fell short of the acclaim brought by Ready to Die, commercially, this album hit the same level of success as every other Bad Boy debut. Harlem World reached the pole position across music charts, sold over 2,000,000 copies to date and was nominated for Best Rap Album at the 41st Grammy Awards.
Salute to Ma$e, Diddy and the Bad Boy fam for this piece of Hip-Hop history!
bad boy recordsbig ldmxHarlem World albumjay-zMa$eMurder Ma$epuff daddythe l.o.x.today in hip hop history
The Source Magazine Staff Writer The Five Percenter Newspaper Parliament Editor


One of the sessions I attended at CEIC 2013 was cybersecurity expert and former FBI counterterrorism and counterintelligence operative Eric O'Neill's talk, "How the World Will End: The Spy Is in the Cybersphere." One of the many very interesting points he brought up was his belief that the critical infrastructure will be attacked, and that attack will be soon. I turned to the woman sitting next to me and said, "I'm glad I'm not the only one who has been saying that." After the session, O'Neill and I spoke briefly about his comments, and we agreed that predicting such a breach isn't really going out on a limb, but it was time that we all began to understand the seriousness of a potential breach.
In the latest operations, the Iranian hackers were able to gain access to control-system software that could allow them to manipulate oil or gas pipelines. They proceeded "far enough to worry people," one former official said.
The article went on to echo a theme of CEIC's cybersecurity component – while the Chinese are a serious threat, that threat is mainly to our intellectual property (and in my not so humble opinion, it is the growing threat of losing money based on that intellectual property that will eventually make corporations take cybersecurity more seriously). It is other countries, particularly those in parts of the world with unstable or dictatorship-type governments, that are going to be the real threat to our national security and our critical infrastructure.
Industrial control systems such as those used to control oil and gas pipelines are more interconnected with public networks like the Internet than most people realize. It is also difficult to fix security flaws with these systems because they aren't designed to be patched and restarted frequently. It is extremely important that operators of industrial control networks monitor those networks with systems that can identify anomalous activity that might be associated with an attack.
The scary yet untold part of this story is it probably took the energy companies months to figure out they had been compromised, and then it takes even longer to figure out the extent of the infiltration. This is a dangerous threat because the hackers were able to gain access to control-system software vs. DoS.
I read an article after the $45 million bank cyberheist that stated the real cybersecurity threat isn't to the critical infrastructure, but to the financial industry. The article said that we deal with blackouts and water shortages all the time during hurricanes and other acts of Mother Nature. I think the author missed the point. This isn't an "all or nothing" situation. Yes, fooling around with the financial sector has a danger all its own, and we saw how the breach of AP's Twitter account, the one that said the White House was under attack, can affect the markets. But a cyberattack on the critical infrastructure isn't going to be the same as the power going out after a bad storm. It will be a layered attack – first the infrastructure, which will lead to the financial sector.
So the question we must ask is why is the critical infrastructure so connected to the Internet and outside sources? And then, what security steps are being taken on the inside to make sure the networks that aren't connected aren't corrupted by an attack in the manner of Stuxnet, which happened via flash drive.
It's time to start paying attention to the critical infrastructure. As DiBello said to me, the experts aren't over-hyping the threat. It is real.


India put up a spirited bowling performance before Mumbai youngster Sarfaraz Khan struck an unbeaten half-century to steer the team to a seven-wicket win over Bangladesh and clinch the Under-19 Tri-series ODI tournament title in Kolkata.
After bundling out Bangladesh for 116 in 36.5 overs, India reached 117 in just 13.3 overs, losing three wickets in the process.
Opting to bat, Bangladesh kept losing wickets at regular interval as the home team bowlers wreaked havoc with left-arm spinner Mayank Dagar scalping three for 32, while Shubham Mavi (2/21) and Mahipal Lomror (2/11) claiming two wickets each at the Jadavpur University second campus ground in Salt Lake stadium.
Chasing a modest target, India suddenly found themselves struggling at 42 for three in 6.3 overs from 38 for no loss.
But Sarfaraz, who plays for Uttar Pradesh in the Ranji Trophy, steadied the boat.
He hit a blistering 27-ball 59 not out (9x4, 3x6) and in the able company of skipper Ricky Bhui (20 not out from 20 balls; 4x4) put up an unbroken 75-run match-winning partnership to chase down the target in the 14th over.
The burly Mumbai right-hander, who had a quiet tournament before the match, returned to form with a superb knock. He was particularly brutal against Bangladeshi left-arm spinner Saleh Ahmed Shawon Gazi as he raced to the fastest half-century of the tournament.
Gazi conceded 15 runs and 20 runs from his ninth and 11th overs, respectively with Sarfaraz striking 4, 6 and 4 before following it up with 4-6-4-4 in the next over to reach to his fifty in 23 balls.
Sarfaraz had a close call on 11 when his flashy drive over covers was missed by an outstretched Pinak Ghosh, who failed to get on to the difficult chance.
Earlier, Sarfaraz had knocks of 2, 0 and 12 in his first three matches but he came up with a brilliant performance when it mattered the most and was adjudged the man-of-the-match for his efforts.
Delhi left-hander Rishabh Pant, who topped the run charts (282) with a ton and two half-centuries from four matches, was adjudged the man of the series.
Congress opposes GST bill, Sonia meets Modi: What exactly are the sticking points?
READ NEXT >> Congress opposes GST bill, Sonia meets Modi: What exactly are the sticking points?


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First Student Reminds Motorists to #StopOnRed During National School Bus Safety Week
Despite being big and bright, school buses are often overlooked by distracted drivers who don't notice the bus lights until it's too late. First Student is reminding motorists to #StopOnRed! in support of National School Bus Safety Week, October 16-20.
Passing a stopped school bus is illegal in all 50 states. However, in its 2017 national stop arm survey, the National Association of State Directors of Pupil Transportation Services (NASDPTS) tallied more than 78,000 stop arm violations in just one day, which equates to more than 14 million illegal passes over the course of a 180-day school year.
"School buses are the safest form of transportation on the road today," said First Student President Dennis R. Maple. "Our drivers take tremendous care when transporting students, but it is also crucial for motorists to pay attention, avoid distractions and watch for yellow school buses. Everyone in the community plays a role in ensuring students travel to and from school safely. Together, we can prevent injuries and save lives."
School buses use yellow flashing lights to alert motorists that they are preparing to stop to load or unload children. Red flashing lights and an extended stop sign arm indicate the bus is stopped and students are getting on or off the bus.
All states require traffic in both directions to stop on undivided roadways when students are entering or exiting a school bus. While state laws vary on what is required on a divided roadway, in all cases, traffic traveling behind the school bus must stop and wait until the red lights stop flashing, the extended stop sign is withdrawn, and the bus begins moving.
Each year the National Association for Pupil Transportation (NAPT) sponsors National School Bus Safety Week and a student poster contest as a way to bring national and local attention to school bus safety. #StopOnRed! is the theme for 2017.
First Student is also promoting stop arm safety with the nationwide Safety Dog Bus Tour. The eight-city Tour wraps up during National School Bus Safety Week with a stop in Springfield, Illinois on October 17. Visit safetydogbustour.com for more information and helpful safety tip sheets.
About First Student, Inc.As the leading school transportation solutions provider in North America, First Student strives to provide the best start and finish to every school day. First Student completes five million student journeys each day, moving more passengers than all U.S. airlines combined. With a team of highly-trained drivers and the industry's strongest safety record, First Student delivers reliable, quality services including full-service transportation and management, special-needs transportation, route optimization and scheduling, maintenance, and charter services for 1,100 school district contracts. For more information, please visit firststudentinc.com.
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Experts estimate that up to 80% of the population will suffer from back pain at some point in their lives. That's an incredibly high number! Back pain is also the third most common reason for visits to the doctor, yet many don't know when to seek out the care of a spine specialist. In addition, there are many individuals who don't fully understand the root cause of their symptoms.
As a Physician Assistant in a specialized spine practice for over 10 years, I will simplify the three most common low back conditions.
Low back pain is commonly a result of disc degeneration in the lumbar spine. Cartilage wear and tear happens to all of us each day that we are alive and live under the heavy weight of gravity. In the spine, the bones that support our bodies (vertebral column) are separated by a thick cushion of cartilage called the disc, which provides support and movement. Genetics play a large role in determining the age at which our discs start to deteriorate and how fast they degenerate over the course of our lives. Additionally, our activity level and how much we use our discs adds to the genetic trajectory. The higher the impact and force, particularly in a repetitive fashion, the more likely this will speed up the degenerative process.
On the other hand, complete inactivity, weight gain, poor flexibility and improper body mechanics can be just as harmful in wearing out the discs. What's worse in this scenario is that pain seems to be less tolerated making treatments less successful.
Lastly, the most detrimental factor for discs is nicotine in any form (smoking, vaping, chewing tobacco, etc). Nicotine kills the oxygen and nutrient supply to the discs wearing them out at an exponential rate. When I discuss this with patients, it seems they are surprised by this information, but are glad that removing nicotine use can be the very best way to change their future.
The description of low back pain caused by disc degeneration is similar in most patients.The pain is worse with prolonged positions particularly sitting, long car rides, repetitive bending or prolonged bending such as gardening or cleaning the bathtub. These patients will feel some improvements with lying down and extending their back for a good stretch. If this sounds like you, but you don't think the symptoms are "bad enough" to seek expert care with a spine specialist, think again!
Seeing a spine specialist is so important as early as possible. At Virginia Spine Institute, our goal is to focus our treatments on non-operative care particularly if disc degeneration is the main diagnosis. That goal is often achieved by empowering our patients with a better understanding of why they hurt and arming them with the tools to achieve success through fitness and conditioning with a proper rehab program designed for each individual. We provide our patients with plenty of treatment options and help them arrive at the one that is best suited for their condition. When presenting patients with non-operative treatment solutions, we like to discuss the latest alternatives to surgery in the form of regenerative medicine. These outpatient procedures utilize the body's healing power to repair damaged tissue, improve pain and further the success of fitness and conditioning over many years to decades.
Spinal stenosis is narrowing around the nerves which can occur when the structures surrounding the nerves are wearing out. This can be due to disc bulging, disc herniation, joint enlargement, ligament thickening or some combination. This narrowing can affect one nerve, multiple nerves or the entire canal of nerves in the middle. If one nerve is pinched, there is often radiating pain down one leg in a particular pattern (the back of the thigh and the calf for example). If multiple nerves are pinched or narrowed, then the pattern can be more diffuse (the outside and back of the thigh, calf, top and bottom of the foot). These patients experience increased symptoms when the pinched nerve is stretched (ie: bending over to touch the toes without bending the knees). If there is stenosis surrounding the large canal of nerves in the center of the spine, then patients often describe buttock and leg pain with standing and walking, which is quickly relieved with sitting and partially relieved with bending.
No matter where the nerves are pinched, patients often describe nerve pain as being severe and unlike any other pain they've experienced. Although surgical intervention can be effective to relieve the pressure from the nerves, we can often improve or resolve symptoms with an injection and physical therapy to include traction. The sooner you see a spine specialist will increase the likelihood of resolving the pain with non-operative treatment. Don't delay prompt evaluation in this case!
There are many joints in and around the spine that can cause back pain. There are two facet joints associated with each disc that can wear out and cause back pain. This type of pain is often made worse by extending the back and might improve with bending forward. The sacroiliac (SI) joints are often sources of low back pain which can involve one or both sides. This joint connects the sacrum to the pelvis, is very large, and can become inflamed and painful. There can be restriction (too little motion) or hypermobility (too much motion) of the SI joints. If you have a lumbar spine issue, the SI joints can be a common place to manifest pain even though the SI joints are not abnormal themselves. SI joints can also become inflamed by a simple fall such as during ice skating or skiing. They can become inflamed during or after pregnancy as the pelvis expands to make room for the baby and then contracts after delivery. A spine specialized physical therapist (such as our team at Virginia Therapy & Fitness Center) trained in manual manipulation and dry needling can be very successful at resolving SI related pain.
I personally have first hand experience with SI pain which occurred during my first pregnancy. After delivery, the pain became much worse. I was having difficulty with lifting the baby in the infant carrier and in and out of the crib. Even just a mild bend forward at the sink to brush my teeth was quite painful. To gain some pain relief, I scheduled a physical therapy evaluation with Larry Grine at Virginia Therapy and Fitness Center. It was amazing! After the evaluation, he diagnosed SI restriction. I laid down on the examination table and he forcefully pulled my leg which manipulated the SI joint back into place. I had immediate relief and was so thankful! I could finally care for my baby without pain.
In terms of myofascial pain, this is more superficial and affects the muscles and connective tissues. This is typically a place we can press on and reproduce symptoms. If a joint deep to the muscle or fascia is restricted and inflamed, then both will need to be treated to improve pain. Physical therapy is key in these cases. If you've had physical therapy, but never had dry needling, then you really should consider spine-specialized physical therapy to experience the benefits of this powerful technique to relieve muscle knots. Don't shy away from the word needle though as these are just tiny acupuncture needles and are very well tolerated by most patients!
If any of these descriptions sound like you, seek the care of a spine specialist with a dedication in both non-operative and operative spine treatments. In most cases we can identify the problem and suggest the proper rehab facility for physical therapy and athletic training which many times relieves symptoms and improves daily function to prevent future issues. This needs to be tailored to each patient by taking into consideration their pathology, their current fitness level and their desired activities and goals.