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Home Books Williams Manual of Hematology, 9e
Chapter 57: Large Granular Lymphocytic Leukemia
Large Granular Lymphocytic Leukemia. In: Lichtman MA, Kaushansky K, Prchal JT, Levi MM, Burns LJ, Armitage JO. Lichtman M.A., & Kaushansky K, & Prchal J.T., & Levi M.M., & Burns L.J., & Armitage J.O.(Eds.),Eds. Marshall A. Lichtman, et al.eds. Williams Manual of Hematology, 9e. McGraw Hill; 2017. Accessed February 01, 2023. https://hemonc.mhmedical.com/content.aspx?bookid=1889&sectionid=137390057
Large granular lymphocytic leukemia. Lichtman MA, Kaushansky K, Prchal JT, Levi MM, Burns LJ, Armitage JO. Lichtman M.A., & Kaushansky K, & Prchal J.T., & Levi M.M., & Burns L.J., & Armitage J.O.(Eds.),Eds. Marshall A. Lichtman, et al. (2017). Williams Manual of Hematology, 9e. McGraw Hill. https://hemonc.mhmedical.com/content.aspx?bookid=1889&sectionid=137390057
"Large Granular Lymphocytic Leukemia." Williams Manual of Hematology, 9e Lichtman MA, Kaushansky K, Prchal JT, Levi MM, Burns LJ, Armitage JO. Lichtman M.A., & Kaushansky K, & Prchal J.T., & Levi M.M., & Burns L.J., & Armitage J.O.(Eds.),Eds. Marshall A. Lichtman, et al. McGraw Hill, 2017, https://hemonc.mhmedical.com/content.aspx?bookid=1889&sectionid=137390057.
T-LGL LEUKEMIA
T-cell large-granular lymphocytic (T-LGL) leukemia results from the clonal expansion of large granular lymphocytes (LGLs) with a T-cell (CD3+) phenotype and a clonal T-cell receptor gene rearrangement(s).
Natural killer (NK)-LGL leukemia is a clonal expansion of LGL with a NK cell (CD3–) phenotype. It lacks convenient markers to determine clonality, such as antigen receptor rearrangements. (See Chap. 66.)
There is suggestive evidence of a role for human T lymphotropic virus (HTLV) retroviral infection in some patients.
Most patients are not infected with either HTLV-I or HTLV-II.
Cytomegalovirus implicated in rare cases of CD4+ T-LGL.
Leukemic cells have features of antigen-activated cytotoxic T lymphocytes, suggesting a role for antigen in initial LGL expansion.
Constitutive overexpression of the Fas ligand (CD178), which also is found at high levels in patients' sera, may be a factor in many disease manifestations (eg, neutropenia, rheumatoid arthritis).
About half of patients have palpable splenomegaly. (Table 57–1)
About one-third of patients have recurrent bacterial infections.
"B symptoms" (eg, low-grade fevers, night sweats, and/or weight loss) (aggressive variant) are very infrequent.
About one-fourth of patients have rheumatoid arthritis, often with features of "Felty syndrome."
Less than one-tenth of patients have lymphadenopathy.
TABLE 57–1CLINICAL FEATURES OF T-CELL LARGE GRANULAR LYMPHOCYTIC LEUKEMIA
Pandolfi (1990)
Loughran (1993)
Dhodapkar (1994)
Semenzato (1997)
Neben (2003)
Bareau (2010)
Number of patients 151 129 68 162 44 201
Median age 55 57 61 59 63 59
Male/Female 1.3 0.8 1 0.8 1.0 0.8
Symptomatic 72% – 69% – 73% 82%
Splenomegaly 50% 50% 19% 50% 35% 24%
Hepatomegaly 34% 23% 1% 32% – 10%
Adenopathy 13% 1% 3% 13% 5% 6%
B symptoms – – 12% – – 7%
Infections 38% 39% 15% 56% – 23%
Rheumatoid arthritis 12% 28% 26% 36% 20% 17%
Rheumatoid factor – 57% 61% 43% 48% 41%
Antinuclear antibodies – 38% 44% 38% 48% 48%
Autoimmune cytopenias – – 7% 9% 5% 7%
Lymphocytosis 29%
LGL > 4 × 109/L 52% 52% – – – 14%
LGL 1–4 × 109/L 38% 40% – – – 50%
LGL < 1 × 109/L 10% 8% – 7% – 36%
Neutropenia
Moderate (< 1.5 × 109/L) 64% 84% 74% – 52% 61%
Severe (0.5 × 109/L) 7% 48% 40% 37% 41% 26%
Any severity 25% 49% 51% 26% 89% 24%
Severe (Hgb < 8 g/dL) 37% – 19% – 36% 7%
Thrombocytopenia 9% 19% 20% 29% 36% 19%
LGL marrow infiltration 67% 88% – 76% 83% 72%
Hypergammaglobulinemia – 45% 5% 43% – 35%
Monoclonal gammopathy – 45% 8% – – 10%
Need for treatment 30% 73% 69% 33% 80% 44%
LGLL-related death 14% 36% 8% 27% – 7%
Hgb, hemoglobin; LGL, large granular lymphocyte; LGLL, large granular lymphocytic leukemia.
Modified with permission from Bareau B, Rey J, Hamidou M, et al. Analysis of a French cohort of patients with large granular lymphocyte leukemia: A report on 229 cases. Haematologica. 2010;95(9):1534–1541.
Source: Williams Hematology, 9th ed, Chap. 94, Table 94–1.
Approximately half of the patients have anemia, often caused by pure red cell aplasia and/or autoimmune hemolytic anemia.
Approximately one-fifth of patients have thrombocytopenia.
Nearly three-fourths of patients have neutropenia, often less than 0.5 × 109/L.
About one-fourth of patients do not have increased blood total lymphocyte counts.
The median LGL count in patients is 4.0 × 109/L (normal mean: 0.3 × 109/L) (Figure 57–1).
Immunophenotype of LGL cells in blood and marrow: CD3+CD8+CD16+CD57+CD4–CD56–, and, often, HLA-DR+.
LGL cells have clonal T-cell–receptor gene rearrangement(s), usually involving α and β chains.
Patients commonly have elevated levels of certain autoantibodies and other serologic abnormalities (see Table 57–1).
More than 90% of patients have LGL infiltration of the marrow and splenic red pulp.
Marrow infiltration may be nodular or interstitial. If interstitial, it may be difficult to appreciate involvement without staining for neoplastic cells using immunocytochemistry (Figure 57–2).
FIGURE 57–1
Buffy coat blood film. High magnification image of two large granular lymphocytes (LGLs) displaying larger size than characteristic blood small lymphocytes and with more cytoplasm. Cytoplasmic granules are conspicuous in both LGLs. (Reproduced with permission from Lichtman's Atlas of Hematology, www.accessmedicine.com.)
Morphology and immunohistochemical analysis of T-cell large-granular lymphocytic (T-LGL) leukemia in peripheral blood (PB) and bone marrow (BM). Upper panels show high-power images of circulating large granular lymphocytes (LGLs) from a patient with T-LGL leukemia (original magnification = 500×). Note for comparison the small lymphocyte next to the LGL in the right panel. LGLs are slightly larger than other lymphocytes, and they have more nuclear membrane irregularity, moderate amounts of pale blue cytoplasm, and fine cytoplasmic granules. The lower panels show foci of atypical clusters of CD8+ (left) and granzyme B+ (right) lymphocytes in the bone marrow of a patient with T-LGL leukemia (original magnification = 500×). The identification of atypical clusters of at least eight CD8+ and/or at least six granzyme B+ lymphocytes supports the diagnosis of LGL leukemia in the appropriate clinical setting. (Source: Williams Hematology, 9th ed, Chap. 94, Fig, 94–1.)
T-LGL leukemia should be considered in patients with increased blood LGL counts and the following:
— Chronic or cyclic neutropenia
— Pure red cell aplasia
— Rheumatoid arthritis
T-LGL leukemia can be distinguished from NK-LGL leukemia by immunophenotype and clonal T-cell–receptor gene rearrangement. NK-LGL leukemia is a much more aggressive disease.
Hepatosplenic T-cell lymphoma typically occurs in young men and follows a more aggressive course. (See Chap. 66).
Therapy, Course, and Prognosis
This disease is usually chronic, and treatment is not always indicated.
Unusual cases that coexpress CD3 and CD56 may have a more aggressive clinical course.
Significant morbidity/mortality from infections occurs.
Indications for therapy include (1) severe neutropenia or moderate neutropenia and infection, (2) transfusion-dependent anemia, (3) platelet count < 50 × 109/L, and (4) coincident autoimmune diseases requiring therapy.
Low-dose methotrexate 10 mg/m2, orally, once weekly or cyclophosphamide 100 mg, orally, daily, or cyclosporine may be effective in alleviating neutropenia/anemia.
For a more detailed discussion, see Pierluigi Porcu and Ahron G. Freud: Large Granular Lymphocytic Leukemia, Chap. 94 in Williams Hematology, 9th ed.


This video lesson covers all the sections of the new song by Ed Sheeran. Includes chord diagrams, strumming pattern and song sheet.
Here are the diagrams for all the chords used throughout the song.
"Castle on the Hill" by Ed Sheeran. It was released as a digital download on 6 January 2017 as one of the double lead singles from his third studio album ÷ (2017), along with "Shape of You". "Castle on the Hill" was written and produced by Ed Sheeran and Benny Blanco. The song refers to Framlingham Castle in Sheeran's home town.
Released on the same day as "Shape of You", "Castle on the Hill" reached number two in a number of countries, including the UK, Australia and Germany, while "Shape of You" debuted at number one. It was first time in the history of the UK, Australian and German charts that an artist has taken the top two chart positions with new songs. The song debuted at number six in the US, while "Shape of You" entered at number one; this made Sheeran the first artist ever to have two songs simultaneously debut in the US top 10.
"Castle on the Hill" debuted at number two on the UK Singles Chart on 13 January, selling 193,000 combined units in its first week. Sheeran also debuted at number one with "Shape of You", making him the only artist in UK chart history to debut in the top two positions in the same week. The song was certified silver in the first week due to selling 200,000 units. The song remained at number two in its second week, selling 100,000 units. The song spent a further three weeks at number two, and spent fourteen weeks in the top ten altogether. As of September 2017, the song has sold 1.7 million combined units in the UK, 479,000 of these are actual sales, with 119 million streams. On the Scottish Singles Chart, "Castle on the Hill" debuted at number one, ahead of "Shape of You".
The song debuted at number six on the Billboard Hot 100, selling 171,000 downloads and gaining 13 million streams in its debut week in the US. Sheeran also became the first artist to debut two songs in the top 10 in the same week in the history of the Hot 100, with "Shape of You" also debuting at number one. As of September 2017, "Castle on the Hill" has sold 821,000 downloads in the US.


Inshore and nearshore fishing along Florida's Gulf Coast has as much to do with economics as it does with species. Of course, many inshore anglers long to be aboard a big sport fishing boat trolling the depths of the Gulf for fish of mammoth proportions. The reality, however, of a round trip that has fuel costs approaching that of the purchase price of a small outboard motor is staggering to many anglers. Inshore fishing, which includes small-boat, bridge, bank, beach and pier fishing, is much more accessible to the general public. So many game fish species come close enough to Florida's Gulf shoreline that most anglers need only expend a minimum effort in catching dinner on a low-impact, low-cost outing. One species that's of interest to both small boat and large boat anglers is the "convict" fish, or sheepshead.
Sheepshead, found all along Florida's Big Bend coast, are notorious bait stealers. During most of the year, these small-mouthed fish inhabit coastal oyster and rock bars, docks and rock jetties searching for their favorite prey—crustaceans, including small crabs, shrimp and even barnacles. It's these smaller fish that are very difficult to catch, as their ability to crush bait, swallow the meat, and spit out the exoskeleton (with your hook) is unrivaled. Small hooks and small baits, such as fiddler crabs and cut shrimp pieces, are the key to catching sheepshead close to shore. Patience helps, too. Learning to feel the signature bite of a sheepshead takes time, and you'll likely miss a few before you get into the rhythm. And, while the size limit on sheepshead currently twelve inches, a fish that size yields very little meat upon cleaning.
It's the bigger spawning sheepshead, usually found during the late winter or spring that excite Gulf anglers. These fish, found mostly in deeper water and around structures such as rock pies, reefs and old navigation markers, sometime reach weights of 10 pounds or more. When their spawning ritual begins, mature sheepshead will mill around structure and seemingly eat any bait presented them. Chumming with crushed crabs, oysters, barnacles or shrimp heads will increase the feeding frenzy. But don't over-chum. They're hungry, but they do get full. Spawning fish are mature, larger fish and their mouths are bigger. Most anglers rely on whole live shrimp as bait. Fiddler crabs are excellent bait, too, but they're sometimes hard to find.
Fiddler crabs can be found on shallow beaches all along the Big Bend, as well as at local marinas during the early spring.
To catch sheepshead, a simple knocker rig and a sturdy size 2 hook is sufficient, but many anglers simply thread a shrimp, tail first, onto a 3/8-ounce jig head. The advent of braided fishing line has certainly hurt the sheepshead population in the last few years, allowing anglers a better feel for what's going on down below. Many sheepshead experts agree that you have to set the hook on a sheepshead before it bites, or you'll miss the hookup.
Sheepshead are delicious to eat but as difficult to clean as they are to catch. Big-boned and heavily scaled, the meat-to-total-weight ratio of sheepshead is low, and many anglers opt to clean them with electric knives. And, no matter how good the meat, cleaning the unrealistic legal limit is a chore. Take what you can eat that night and not the eight-fish limit, remembering that big spawning sheepshead represent the future of that species.
Sheepshead fillets, piccata, is an excellent way to prepare this species. It also works well with other fish, such as spotted seatrout, snapper or grouper.
Heat a large skillet over medium-high heat. Once hot, add the olive oil and 2 tablespoons of the butter. Season the fillets with salt and pepper and dust lightly with the flour. Once the butter foams and begins to brown, add the fish fillets, turn the heat to high, and brown well, turning once, 4 to 5 minutes total.


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ABOUT-TOWN
Video: wbir
Robin Hood and the Sheriff of Nottingham coming to Knoxville Children's Theatre
The play opens Friday, August 16, and runs weekends through September 1.
Author: Emily Stroud
Published: 1:41 PM EDT August 13, 2019
Updated: 10:01 AM EDT August 14, 2019
KNOXVILLE, Tenn. — Knoxville Children's Theatre presents a live stage adaptation of the classic adventure tale, "The Ballad of Robin Hood."
The actors will perform a version written by the theatre's founder, Zack Allen.
August 16 through September 1
Thursdays and Fridays at 7 pm
Saturdays at 1 pm and 5 pm
Sundays at 3 pm
The play features actors from ages 10 to 16.
Eason Bullard, plays Robin Hood, Emmalee Merrill portrays Maid Marion, and Oliva Rhea plays Catherine, the scheming daughter of the Sheriff of Nottingham, who is played by Alex Montgomery.
The rest of the cast features Truman Ball, PJ Copeland, Cooper Delamain, Ethan Elder, Sophia Elkins, Joshua Howerton, Tripp Keeton, Wyatt Keeton, Mateo Meija, Cordelia Nelson, Deshaun O'Keefe, and Sydney Parman.
Knoxville Children's Theatre
109 E. Churchwell Avenue
RELATED: See what else is happening this weekend in 10 About Town

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Search University of British Columbia Library Rare Books and Special Collections
University of British Columbia Library Rare Books and Special Collections
Fonds RBSC-ARC-1283 - International Woodworkers of America, Western Canadian Regional Council No. 1 fonds
International Woodworkers of America, Western Canadian Regional Council No. 1 fonds
1943-1982 (Creation)
International Woodworkers of America. Western Canadian Regional Council No. 1
4.6 m of textual records;79 microfilm reels;ca. 10,800 photographs
The International Woodworkers of America was formed in Portland in 1937. In British Columbia the predecessor of the IWA was the Lumber Worker's Industrial Union. In 1936 the LWIU affiliated with the American Federation of Labor and was to be grouped under the AFL's Carpenter's organization. West Coast discontent with the AFL resulted in a meeting of representatives of the newly organized union locals in the fall of 1936 to form the Federation of Woodworkers which became the IWA in the summer of 1937. The Canadian division of the IWA in British Columbia was known as District Council No. 1 but later became Western Canadian Regional Council No. 1.
The fonds consists of financial records, minutes, correspondence, legal documents, departmental files, broadcast transcripts, proceedings, convention reports, agreements, printed material and copies of the newspaper, British Columbia Lumber Worker. Also included in the fonds is the B. C. Lumber Worker Photograph Collection (1940-1982) which consists of images used in various publications to reflect the activities of the union.
Inventory available. PDF document attached.
International Woodworkers of America. District Council No.1 fonds
Lumber Inspectors' Union, I.W.A. Local 1-288 fonds
Photographs stored in box 1 to 6. Box 1A to 6A contain textual records.
Industries--Forestry
Natural resources--Forests
British Columbia Lumberworker (Subject)
Digital object (External URI) rights area
International Woodworkers of America. Western Canadian Regional Council No. 1 (Creator)


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Dr. Michael Roizen, MDInternal Medicine Dr. Arthur CrowleyUrology Dr. Madeleine CastellanosPsychiatry, Neurology See All
Dr. Madeleine CastellanosPsychiatry, Neurology Dr. Dean Ornish, MDInternal Medicine, Preventive Medicine American Cancer Society See All
Find a Doctor/Pediatric Surgery/DC/Washington
Dr. Kurt Newman, MD
Pediatric Surgery, SurgeryPediatric Surgery | Surgery
Treats Children
Children's National Medical Center General & Thoracic Surgery111 Michigan Ave NW Ste W4-200Washington, DC 20010
Dr. Newman's Background
Dr. Newman, MD is a practicing Pediatric Surgeon in Washington, DC. Dr. Newman graduated from Duke University School of Medicine in 1978 and has been in practice for 40 years. He completed a residency at Childrens Hospital. Dr. Newman also specializes in Surgery. Dr. Newman accepts multiple insurance plans including Aetna, Humana, and Medicare.
Dr. Newman, MD is a practicing Pediatric Surgeon in Washington, DC. Dr. Newman graduated from Duke University School of Medicine in 1978 and has been in practice for 40 years. He completed a residen...Dr. Newman, MD is a practicing Pediatric Surgeon in Washington, DC. Dr. Newman graduated from Duke University School of Medicine in 1978 and has been in practice for 40 years. He completed a residency at Childrens Hospital. Dr. Newman also specializes in Surgery. Dr. Newman accepts multiple insurance plans including Aetna, Humana, and Medicare. More...Less
Childrens Hospital
Medical School, 1978
Learn More About Pediatric Surgery
Q: What is a TLIF surgery?
Q: When is a TLIF surgery performed?
Q: What is the difference between valve repair and valve replacement?
Q: What is tumor banking?
Q: How long can I delay scheduling surgery for an aneurysm?
111 Michigan Ave NW Ste W4-200Washington, DC 20010
Dr. Martin Eichelberger
111 Michigan Ave NW Washington, DC 20010
Dr. Veronica Gomez-Lobo
110 Irving St NW Bldg SUITE Washington, DC 20010
Dr. Matthew Oetgen
111 Michigan Ave NW Ste W4-200 Washington, DC 20010
Dr. Philip Guzzetta
Dr. Jeffrey Lukish
111 Michigan Ave N.W. Washington, DC 20010


When you need a lab test, such as a throat swab or a blood draw to check your cholesterol level or blood sugar, your doctor will likely refer you to an outpatient lab. Edward-Elmhurst Health lets you choose from a variety of convenient locations and flexible hours to make it easy to get your lab work done on your own schedule.
Appointments not required - simply walk in. Wait times may vary.
Some tests require that you prepare in a specific way, such as fasting or collecting a specimen at a certain time. Learn more about what to expect so you can prepare ahead for your lab work.
Many of our lab locations also offer imaging services, such as X-rays, CT scans, mammograms and ultrasound. Learn more about imaging and radiology services at Edward-Elmhurst Health.
Edward-Elmhurst opens new Health Center on Schiller St. in Elmhurst The new Edward-Elmhurst Health Center at 172 Schiller St. in Elmhurst is home to Elmhurst Clinic, Elmhurst Medical Associates and Edward-Elmhurst Lab Services.


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Ballykelly House
The award-winning Ballykelly House uses state of the art technology to support the vision of a living working landscape valued by everyone.
Northern Ireland Local Government Association
Derry City and Strabane
250 to 10,000
Ballykelly House: state-of-the-art DAERA office-space.
by the Department for Agriculture, Environment and Rural Affairs (DAERA)
Located at the former Shackleton Barracks in Ballykelly, the new state-of-the-art DAERA office-space boasts modern, cutting edge technologies and takes an innovative approach to multi-site working across the DAERA network.
DAERA works to support the vision of a 'living, working, active landscape valued by everyone' with a 'balance between a healthy environment, a thriving and sustainable agri-food industry and thriving rural communities'. This building reflects this vision, with large open spaces and glass walls to allow natural light to infiltrate the space and make for an enjoyable working environment.
The move to relocate DAERA to Ballykelly House was a flagship project. Acting as one of three DAERA headquarter buildings, the project was created with the intention of stimulating rural economies.
Ballykelly House was awarded the CEF Construction Excellence 'Commercial Project of the Year 2018' award, with judges commenting on the use of natural light, ventilation and internal space, along with the efficient management of significant changes during the pre-construction stage.
It is important to clearly state the objectives of the building and the project at the outset. For Ballykelly House, this was to provide space for staff to work in a comfortable and productive environment while meeting specific environmental standards. These objectives provided benefits both during construction and while the building is in use.
To ensure the development meets the needs of the staff using the building, a close working relationship and engagement with architects and end users should be encouraged from the planning stage right through the design and construction phase.
Energy costs of the building.
Number of awards won by the building.
Read more: https://www.daera-ni.gov.uk/daera-hq-relocations-0
Quebec Park
A new mixed-tenure housing development was created as part of a wider regeneration project to transform Whitehill & Bordon into a green, healthy, and connected town.
Bath Quays Solar Arrays
Bath Quays is being developed with environmental sustainability in mind through the use of solar arrays, energy efficiency measures and green transport options.
Dinton Activity Centre
Dinton Activity Centre has been designed to be operationally carbon neutral, in response to the councils 2030 target, demonstrating the potential of retrofitting and renewable energy usage towards these goals.
Bristol Community Energy - a new share offer is open
Save our Scottish Swifts!
Cwm Arian Renewable Energy (CARE)


Central Florida Disaster Medical Coalition Advances its Mission to Develop and Promote Healthcare Emergency Preparedness and Response – BOLDplanning Inc.
The Central Florida Disaster Medical Coalition (CFDMC) continued its fostering of a preparedness culture among members and healthcare providers this week.
With goals of building, strengthening and sustaining healthcare preparedness and response in Central Florida through BOLDplanning-led Continuity of Operations (COOP) Plan Development Workshops, almost 20 healthcare providers learned about COOP planning and how it applies to their facilities, as well as how they can work together in emergency situations.
BOLDplanning applauds Lynne Drawdy and the CFDMC, along with all of its members, in their efforts to build sustainable partnerships and disaster readiness among its members.


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Diplopeltis eriocarpa är en kinesträdsväxtart som först beskrevs av George Bentham, och fick sitt nu gällande namn av Hemsley. Diplopeltis eriocarpa ingår i släktet Diplopeltis och familjen kinesträdsväxter. Inga underarter finns listade i Catalogue of Life.

Källor

Kinesträdsväxter
eriocarpa

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Today Nokia has become a brand name for good mobile phones throughout the world. This is the result of consistent effort towards the manufacturing of world's most efficient and finest mobile phones and accessories. Nokia Networks India has captured the Indian market most strategically since 1995.
Today Nokia has become a brand name for good mobile phones throughout the world. This is the result of consistent effort towards the manufacturing of world's most efficient and finest mobile phones and accessories. Nokia Networks India has captured the Indian market most strategically since 1995. In India, Nokia Network expands with 15000+ people, directly and indirectly, 20 base offices over 100 locations, 280 million subscribers only in India through 230,000 sites served by our proud products. Only the Global Delivery Centers at Chennai & Noida manages more than 200 million subscribers solely from across 86 countries throughout the world. Nokia Network India also proudly hosts its Global R&D center in Bengaluru with 3000 employees on board. Nokia proudly stands to be India's largest International Telecom infrastructure manufacturer being the pioneer in bringing technologies like 3G and LTE to the market.


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Al-Saadi al-Gaddafi ou Saadi al-Gheddafi (em árabe: الساعدي معمر القذافي - Trípoli, 25 de maio de 1973) é um empresário e ex-futebolista líbio.

É filho do ex-ditador líbio Muammar al-Gaddafi, morto em 2011 , depois de 42 anos no poder.

Carreira como jogador
Sem espaço no inexpressivo futebol líbio, Al-Saadi iniciou sua carreira apenas em 2000, no Al-Ahly, principal clube do país. O mais curioso de sua primeira passagem pelo futebol é que ele contratou o canadense Ben Johnson (ex-medalhista nas Olimpíadas de Seul, em 1988, mas que teve sua medalha cassada por doping) para ser seu preparador físico, o ídolo argentino Diego Maradona como seu assessor e o treinador Carlos Bilardo (campeão mundial com a Argentina, em 1986) para ser o treinador da Seleção nacional. Em 6 de junho, a emissora de TV britânica BBC noticiou que o atacante tivesse se transferido para o Birkirkara de Malta, mas essa notícia foi logo desmentida.

No mesmo ano, mais por influências políticas do que por sua habilidade, foi convocado pela primeira vez para a Seleção da Líbia. Em pouco tempo foi alçado à condição de capitão dos verdes. Ele, que acabaria mostrando destempero e teve diversas atuações ruins, virou pivô de demissões de treinadores, e entre eles estava justamente Carlos Bilardo. Outro treinador, o italiano Franco Scoglio, chegou a não convocar o atacante para duas partidas. Al-Saadi jogou pela Seleção Líbia até 2006.

Primeiro líbio no futebol europeu
No ano de 2002, Muammar al-Gaddafi, ditador da Líbia e pai do atacante, resolveu investir seu dinheiro no futebol após 20 anos utilizando sua fortuna com armamentos. Comprou dos patriarcas da família Agnelli, proprietária da FIAT, 7,5% da ações da Juventus de Turim. Nesta época, "Gaddafi pai" cogitou a entrada de seu filho no time principal da Vecchia Signora, mas tal tentativa foi um fracasso. Ainda em 2002, tentou comprar 20% do clube, mas também não obteve sucesso. Porém, o polêmico líder líbio conseguiu comprar a Triestina por "apenas" US$ 4 milhões no mesmo período e chegou a firmar uma parceria de US$ 600 mil anuais com a Lazio para que o Al-Ittihad treinasse em suas instalações. Até mesmo o São Paulo fez parte do rol de "agraciados" com a visita do filho do ditador. Em 2003, o clube de Trípoli esteve no CT do São Paulo para um amistoso contra os reservas tricolores e empatou por 1 a 1.

Depois da curta passagem pelo Brasil, Al-Saadi acertou transferência para o Perugia (supostamente, mais por questões financeiras). Apesar de ter feito história como o primeiro jogador líbio a atuar no futebol europeu, o atacante protagonizou um fiasco: atuou em uma única partida, e deixou o Perugia em 2003. O clube acabaria sendo rebaixado após Al-Saadi ter sido pego no exame antidoping.

Mesmo assim, o líbio não desistiu da carreira, ao ser contratado pela Udinese, equipe com mais tradição do que o Perugia. Os líbios aguardavam a estreia com ansiedade, mas, apesar da expectativa, Al-Saadi protagonizou mais um fracasso, mais retumbante do que sua passagem pelo Perugia: em duas temporadas, foi relegado por ordem do treinador Serse Cosmi, e não jogou mais do que dez minutos, contra o Cagliari, Aborrecido, Al-Saadi resolveu pular fora dos friulanos.

Entretanto, a Sampdoria resolveu investir em sua contratação. Novamente, a contratação do filho de Muammar al-Gaddafi mostrou-se um grande fracasso - ele não entrou em nenhuma partida, e enquanto possuía contrato com a Samp, ele era apenas uma obscura décima opção - Emiliano Bonazzoli, Fabio Quagliarella e Fabio Bazzani eram as principais opções para o ataque, Rubén Olivera era quarta opção, Francesco Flachi era a quinta opção, Danilo Soddimo era o sexto nome para o ataque, Pietro Arnulfo era a sétima alternativa, Salvatore Foti ficava como nona alternativa e Gabriel Ferrari era o décimo nome para o ataque da Sampdoria.

Decepcionado com sua passagem fugaz e sem chances pelo clube de Gênova, Al-Saadi resolveu voltar para a Líbia e terminar sua carreira de jogador.

Carreira empresarial
Ainda em 2006, o ex-atacante lançou um projeto ao governo de seu país para criar uma cidade de caráter semi-autónomo semelhante ao de Hong Kong, que se estendia 40 km entre Tripoli e a fronteira com a Tunísia. A cidade-autônoma proposta se tornaria um centro de alta tecnologia, serviços bancários, médicos e educacionais que não exigiriam visto para entrar. Ela teria o seu próprio aeroporto internacional e um importante porto marítimo. O filho de Muammar al-Gaddafi prometeu tolerância religiosa com a construção de "sinagogas e igrejas" e a não-discriminação na nova cidade, que teria "estilo ocidental".

Envolvimento nos protestos contra o governo
Desde que a Revolta na Líbia em 2011 estourou, Al-Saadi se tornaria comandante das Forças Especiais da Líbia, mas um alerta da Interpol foi emitido contra ele.

Em 11 de setembro de 2011 ele fugiu da Líbia e foi interceptado uma patrulha das forças armadas do Níger .

Em 29 de setembro de 2011, a Interpol emitiu colocou Saadi na lista dos mais procurados, com base em um pedido do novo regime líbio, que o acusou de "intimidação armada" e "apropriação indébita" enquanto dirigia a Federação de Futebol da Líbia, e também de ter dirigido uma unidade militar que reprimiu brutalmente manifestações contra o regime deposto , entretanto, o governo do Niger negou a possibilidade de extradição pois não havia garantias de que haveria um julgamento justo e havia risco de pena de morte, mas declarou que Saadi poderia ser interrogado por agentes do novo regime líbio em Niamey, capital do país .

Futebolistas da Líbia
Futebolistas do Al-Ittihad Sport, Cultural & Social Club
Futebolistas da Udinese Calcio
Futebolistas da Unione Calcio Sampdoria
Futebolistas da Associazione Calcistica Perugia Calcio
Família Gaddafi
Naturais de Trípoli
Casos de doping no futebol


French doors are usually seen as a matching pair of double, outward opening, doors; popular for both internal and external use. Although they are normally fitted opening outward, there is no reason to stop you choosing a set that open inwards.
For each opening style, it's important to have good quality locks because of the centre opening double leaf configuration; dead bolts, shoot bolts & multi point locks are recommended. Look for locks that are anti-levering, pick, snap & bump resistant as they should be readily available.
A common complaint with wooden French doors is that after some time they warp and stick, often becoming difficult to open and close; this can lead to further damage from having to use more "force" to close the doors.
New Upvc designs for the frames and doors mean they don't expand and contract like traditional wooden French doors, remaining flush fitting and easy to use for many years.
Specialised moldings can also be used to give the frames extra character, and are now available in a wide range of colours: but white still remains the most popular as the "classic" French door look.
If you are not quite sure about whether French Doors is your "thing", then why not review some other options to see if they have the right look for your home.
With so many options there is sure to be a style that works for your property.


text:
Conundrum – Young Vic Theatre, London
Home/Musical/Legally Blonde The Musical – Norwich Theatre Royal
MusicalReviewSouth East
Legally Blonde The Musical – Norwich Theatre Royal
The Reviews Hub - North West27/03/2018
Book: Heather Hach
Music and Lyrics: Laurence O'Keefe and Nell Benjamin
Director: Anthony Williams
Reviewer: Lu Greer
Based on the 2001 film Legally Blonde the Musical follows Elle Woods as she gets into Harvard Law purely to win back an ex-boyfriend. What could easily be an uncomfortable story of a girl who's only ambition is love, is instead the story of a woman who works hard, embraces the bumps in the road, and proves that walking your own path is always the best way (as long as you do it in fashionable heels).
Elle Woods quickly became an iconic character thanks to Reece Witherspoon's portrayal of her in the original film, and the bar was raised yet higher with the likes of Sheridan Smith and Laura Bell Bundy taking on the roll in the West End and on Broadway. It is a daunting role, then, for Lucie Jones to take on for the UK tour. Jones makes the character her own, bringing out Elle's positivity and tenacity, as well as some excellent comedic timing, alongside an outstanding voice. Jones' only issue comes in the dance numbers when it becomes clear that her strength is in her singing and she occasionally looks out of step among the ensemble.
Acting as Elle's mentor, and Jones' co-star, Rita Simons takes on the role of Paulette the hairdresser in a performance that is, of course, particularly memorable during the Bend and Snap song. Simons' voice has a depth that livens up a now extremely familiar song, and she bounces off of Jones well during their back-and-forths. Somewhat surprisingly, one of the stars of the show (after the dogs, of course) is David Barrett as Emmett. While his voice is of the same high quality as the rest of the cast, it is the depth and sincerity he brings to a sea of candyfloss pink that sets him apart. Emmett's background, his emotion, and his feelings are evident throughout Robyn's performance and create a character that the audience genuinely cares for.
Legally Blonde the film will turn twenty in a couple of years' time, and unfortunately, in the musical, its age is starting to show through the glitter, at times. There are pop culture references which should have been updated as times change, and dialogue which sounds outdated. Sometimes, the sets and costumes seem to be feeling their age as well, along with the choreography, where at one time they would have been sharp and on point they now feel like a reminder of the past. There is also a fine line to be trodden in a show such as this, which should be championing a woman and her power. It does this successfully through most of the show with Elle showing the men around her exactly what she's made of, but at its heart, it's still a show about a woman purely responding to the men in her life, and Bend and Snap while a classic song, has begun to feel a little uncomfortable.
At the end of the day, this is not a serious show, but it's not supposed to be. It's the story of a woman learning, growing, and changing, without losing sight of who she is. And it's a story that's told with comedic timing, stellar voices, and stand out songs.
Legally Blonde doesn't offer anything new. It's a little worn around the edges. But ohmigod you guys – I totally promise you'll leave smiling and singing.
Runs Until: 31st of March, 2018 | Image: Contributed
The Reviews Hub Score
Snaps!
Anthony Williams David Barrett Heather Hach Laurence O'Keefe Legally Blonde Lucie Jones Nell Benjamin New Theatre Royal Rita Simons Theatre Royal
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The Reviews Hub - North West
The North West team is under the editorship of John Roberts. The Reviews Hub was set up in 2007. Our mission is to provide the most in-depth, nationwide arts coverage online.