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Commercial Packaging & Logistics
Clinical Trial Services
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Dividend Distribution Letter
Recro Pharma Provides Pipeline Update
Download as PDF October 26, 2015 8:00am EDT
IV Meloxicam Advancing to Phase III; Pivotal Trials Expected to Commence in First Quarter 2016
Company Shifts Focus of Dex-IN to Peri-Procedural Pain Indication
MALVERN, Pa., Oct. 26, 2015 (GLOBE NEWSWIRE) -- Recro Pharma, Inc. (Nasdaq:REPH), a revenue generating specialty pharmaceutical company developing multiple non-opioid therapeutics for the treatment of acute pain, today provided a clinical and regulatory update on its pipeline candidates. In the first quarter of 2016, the Company intends to initiate a pivotal Phase III clinical development program with IV meloxicam, a long-acting, preferential COX-2 inhibitor, for the treatment of moderate to severe acute post operative pain. For Dex-IN, Recro's intranasal formulation of the selective alpha-2 agonist analgesic, dexmedetomidine, the Company plans to continue to study Dex-IN in painful conditions with a focus on the treatment of peri-procedural pain.
"The decision to advance IV meloxicam into Phase III is an important milestone for Recro and we are excited about the opportunity this candidate represents as a new option for moderate to severe pain in the acute, post operative setting," said Gerri Henwood, Recro Pharma's President and Chief Executive Officer. "Following the successful submission and review of additional FDA requested clinical and nonclinical information and the availability of new clinical drug supply, we expect to initiate the Phase III trials during the first quarter of 2016."
Ms. Henwood continued: "Following our recent discussion with the FDA, we believe the Dex-IN product profile is better suited for peri-procedural pain rather than the post op setting evaluated in our Phase II trial. We are working to design an appropriate Phase II program to evaluate Dex-IN in this patient population. We believe this approach provides the best path forward for this candidate, and we look forward to providing future updates as we progress."
IV Meloxicam for the Treatment of Moderate to Severe Acute Pain
Recro recently met with the U.S. Food and Drug Administration (FDA) to obtain feedback for its proposed IV meloxicam Phase III clinical development program. Based on feedback from the FDA, the Company intends to initiate a Phase III program with IV meloxicam. Recro expects that the Phase III program will include two pivotal clinical trials, as well as other trials. We expect to enroll a total of approximately 1,300 patients in all these trials. One pivotal clinical trial will be designed to demonstrate pain relief over a 48-hour period in a hard tissue, post op pain model, and the other pivotal trial will be designed to demonstrate pain relief over a 24-hour period in a soft tissue, post op pain model. Recro expects to commence the Phase III clinical program during the first quarter of 2016. Recro expects that results from these two pivotal studies, in addition to other clinical trial data and non-clinical data, to be the basis for our New Drug Application (NDA) submission to the FDA for marketing authorization.
The meloxicam clinical program is supported by clinical data from 3 Phase II studies in over 700 patients with acute pain. Results from these studies demonstrated that IV meloxicam has significant analgesic efficacy, including rapid onset of pain relief and time to peak analgesic effect, 18 to 24 hour duration of pain relief and good tolerability.
Dex-IN for the Treatment of Acute Pain
Recro recently met with the FDA to obtain feedback on the Phase II efficacy and safety data, and for its proposed Dex-IN clinical development program. Based on feedback from the FDA regarding Dex-IN's benefit-risk profile, specifically its efficacy and blood pressure effects, which was demonstrated in post op pain, and the subsequent requirements for a post op pain clinical program, the Company believes that such a program is not advisable due to time, cost and associated risks. The Company plans to reevaluate DEX-IN in peri-procedural pain as discussed with FDA. Based on the FDA's feedback, the Company intends to pursue a Phase II dose-ranging program in peri-procedural pain.
The Dex-IN clinical program is supported by clinical data from Recro's clinical studies in which Dex-IN demonstrated significant pain relief compared with placebo.
About IV/IM Meloxicam
Meloxicam is a long-acting, preferential COX-2 inhibitor that possesses anti-inflammatory, analgesic, and antipyretic activities, which are believed to be related to the inhibition of cyclooxygenase (COX) and subsequent reduction in prostaglandin biosynthesis. Meloxicam has been marketed by Boehringer Ingelheim Pharmaceuticals, Inc. since the 1990's as an oral agent, Mobic®. IV/IM meloxicam was designed using NanoCrystal® platform, a technology that enables enhanced bioavailability of poorly water-soluble drug compounds. Recro acquired IV/IM meloxicam from Alkermes in April 2015.
About Dex-IN
Dex-IN is a proprietary intranasal formulation of dexmedetomidine, or Dex. Dex is a selective alpha-2 adrenergic agonist that has demonstrated sedative, analgesic and anxiolytic properties. The Company is evaluating multiple formulations of Dex to target a range of pain indications.
About Recro Pharma, Inc.
Recro Pharma is a revenue generating specialty pharmaceutical company developing multiple non-opioid therapeutics for the treatment of acute post-operative pain. Recro Pharma is currently developing IV/IM meloxicam, a proprietary, long-acting preferential COX-2 inhibitor, and Dex-IN, a proprietary intranasal formulation of dexmedetomidine, for the treatment of acute pain. Both compounds have successfully completed Phase II clinical trials. As Recro Pharma's product candidates are not in the opioid class of drugs, the Company believes its candidates would avoid many of the side effects associated with commonly prescribed opioid therapeutics, such as addiction, constipation and respiratory distress, while maintaining analgesic effect.
Recro Pharma also owns and operates an 87,000 square foot, DEA-licensed facility that manufactures five commercial products and receives royalties associated with the sales of these products.
Cautionary Statement Regarding Forward Looking Statements
This press release contains forward-looking statements that involve risks and uncertainties. Such forward looking statements reflect Recro Pharma's expectations about its future performance and opportunities that involve substantial risks and uncertainties. When used herein, the words "anticipate," "believe," "estimate," "upcoming," "plan," "target", "intend" and "expect" and similar expressions, as they relate to Recro Pharma or its management, are intended to identify such forward-looking statements. These forward-looking statements are based on information available to Recro Pharma as of the date of this press release and are subject to a number of risks, uncertainties, and other factors that could cause Recro Pharma's performance to differ materially from those expressed in, or implied by, these forward looking statements. Recro Pharma assumes no obligation to update any such forward-looking statements. Factors that could cause Recro Pharma's actual performance to materially differ from those expressed in the forward-looking statements set forth in this press release include, without limitation: results and timing of the clinical trials of IV/IM meloxicam and Dex-IN; the ability to obtain and maintain regulatory approval of IV/IM meloxicam and Dex-IN, and the labeling under any such approval; regulatory developments in the United States and foreign countries; the Company's ability to raise future financing for continued development; the performance of third-party suppliers and manufacturers; the Company's ability to obtain, maintain and successfully enforce adequate patent and other intellectual property protection; the successful commercialization of IV/IM meloxicam and Dex-IN; In addition, the forward looking statements in this press release should be considered together with the risks and uncertainties that may affect Recro Pharma's business and future results included in Recro Pharma's filings with the Securities and Exchange Commission at www.sec.gov. Recro Pharma assumes no obligation to update any such forward looking statements.
CONTACT: Argot Partners
Susan Kim
susan@argotpartners.com
Source: Recro Pharma
Copyright © 2022 Recro. All rights reserved.
Packaging and Logistics


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Home Uncategorized These seven Nigerian banks could collapse unless they raise new capital
These seven Nigerian banks could collapse unless they raise new capital
Nigeria's banking industry is experiencing a "full-blown financial crisis" as failed fiscal and monetary policies lead to a credit crunch, according to Arqaam Capital.
Unity Bank Plc and Skye Bank Plc are close to being insolvent, while lenders FBN Holdings Plc and Sterling Bank Plc "will need a dilutive capital hike," Jaap Meijer and Tarek Sleiman, analysts at the Dubai-based investment bank and brokerage, said in an e-mailed note on Monday. Capital ratios are set to worsen because of currency depreciation and souring loans, they said. Calls to Unity weren't immediately returned and Skye didn't reply to questions.
The central bank in July replaced the management of Skye after the lender breached liquidity thresholds, spurring concerns about the health of small- and medium-sized lenders, and reviving memories of bank rescues by the government after the financial crisis in 2009. Nigerian banks are grappling with a devaluation of the naira, rising bad loans and an oil-dependent economy that's set to record its first annual contraction in more than two decades.
"Our acid test reveals seven under-capitalized banks" with a deficit of as much as 1 trillion naira ($3.2 billion) in the financial system, Meijer and Sleiman said. A stress test identified FBN as the most under capitalized lender with Unity, Diamond Bank Plc, Skye, FCMB Group Plc, Sterling and Fidelity Bank Plc also showing deficits if they were to fully provide for non-performing loans, according to Arqaam.
"Our bank is strong," Ikechukwu Mike Omeife, a spokesman for Diamond Bank, said by phone from Lagos. "Our capital-adequacy ratio and non-performing loans are within the statutory requirements."

redpajama_set_name: RedPajamaCommonCrawl


Gospel Luke 21:5-19 but read the whole chapter.
7 They asked him, 'Teacher, when will this be, and what will be the sign that this is about to take place?' 8And he said, 'Beware that you are not led astray; for many will come in my name and say, "I am he!" and, "The time is near!" Do not go after them.
9 'When you hear of wars and insurrections, do not be terrified; for these things must take place first, but the end will not follow immediately.'10Then he said to them, 'Nation will rise against nation, and kingdom against kingdom; 11there will be great earthquakes, and in various places famines and plagues; and there will be dreadful portents and great signs from heaven.
12 'But before all this occurs, they will arrest you and persecute you; they will hand you over to synagogues and prisons, and you will be brought before kings and governors because of my name. 13This will give you an opportunity to testify. 14So make up your minds not to prepare your defence in advance; 15for I will give you words and a wisdom that none of your opponents will be able to withstand or contradict. 16You will be betrayed even by parents and brothers, by relatives and friends; and they will put some of you to death. 17You will be hated by all because of my name. 18But not a hair of your head will perish. 19By your endurance you will gain your souls.
I remember my first fire. It was burning out of control in scrub land which was largely inaccessible due to the terrain. And because it was an army ammunition proofing range. No one was wanting to go in there!
So we farmers (and sons) waited in my uncle's paddock which sat above the scrub. No one was quite sure how to attack the problem. Although minus unexploded shells, the area of below us was still too thick and too steep to get into and burn a fire break.
Four hundred yards below us the leisurely fire front reached the base of our hill. In a space of seconds- less than 10- it had exploded up the slope, far faster than any living creature could run. We fled back into the ploughed paddock. If not for that bare ground we would have been burned alive, almost before we realised.
Explaining the dangers of fire in hill country to someone who has not been there is almost impossible. Friends of mine from the tropics are mystified about why we even have these fires in Australia. Even Australian city dwellers do not really understand the uncontrollable forces at play. Unless we have been there, and perhaps lost friends and family, we do not and cannot understand.
And my first fire was a very small fire.
How does one preach apocalyptic literature to people who are not suffering? Do we have to convince them that they are suffering for this literature to make sense? This type of literature was written during periods of great persecution and suffering; to encourage the believers to remain faithful through the ordeal. Can it speak to our comfortable people today?
I begin to understand the question. I once suggested in a sermon, that I suspected the Sudanese members of our congregation, who are war refugees, might read Mark 13 (the Little Apocalypse, on which much of the material in Luke is based) rather differently to we native born Australians. The serious nods told me I was correct. And the wry smiles from the same Sudanese told me I had no idea how much differently.
How then do I even begin to preach, or read the text for myself? I too have never really suffered. I've only been to the smallest of fires.
• Why? The people have sinned.
• Future may be a time of blessing if the people repent.
By its very nature, eschatology is hyperbolic. It can never be literally interpreted. Its purpose was to warn of judgement to come and to encourage the faithful that, come what may, God is still in control of historical events.
Hyperbole is important. Hyperbole exaggerates to convey the importance and the emotional intensity of an event, but it is not meant to be literal. If we do not recognise hyperbole for what it is, we will be misinterpreting the text.
My fire was such a tiny fire. We won. In 2005 a hundred and forty five thousand hectares were burned in South Australia, in only a few hours. Nine people were killed, ninety three houses burned, and some 47,000 farm animals burned to death, or later put down. At North Shields people survived by fleeing into the sea. One of my friends was burned to death. She had no bare paddock into which to flee; the fire was too great and too fast.
Wikipedia and other places record some bare facts of the event. But we cannot tell the tale without hyperbole.
"The roar of the flames streaming far and wide mingled with the groans of the falling victims; and, owing to the height of the hill and the mass of the burning pile, one would have thought that the whole city was ablaze," wrote Josephus of the destruction of Jerusalem.
Can a survivor of the Eyre Peninsula fires tell the tale truthfully without hyperbole? How much do the bare facts of the event, such as would be placed in a report to a government enquiry, tell the truth and witness to the severity of what happened?
The text is not a prophecy.... but an interpretation of history.
The text has nothing to do with predictions of the future, and any interpretation which treats it so is fatally flawed from the start. Luke was not written primarily for 21st-century Christians anxious about the future. It was written for a beleaguered and persecuted minority under the thumb of Rome. How were they to deal with this situation? Luke says to listen for Jesus, trust in Jesus, and use Jesus himself as a model.
he is repeating history. Jesus is dead. Jerusalem is destroyed. Vesuvius has erupted and buried Pompeii, wars and massacres have multiplied, and the horrified tales have spread across the world with the travellers and soldiers of the empire. People's horror driven hyperbole has been honed around campfires into the mnemonic cadences of tradition. Luke is telling a restrained history of a world often on the border unbearable suffering.
But not a hair of your head will perish. In your endurance, you will possess your lives.
He bears witness to the experience of the church. The text is hyperbole honed by reality and truth, not religious bravado. It is not untried foretelling, but truth tried by fire.
It is like listening to the restrained story of our faith, and our hoped for future, told by a disciple of many years experience, and comparing that to the bravado of young convert whose naiveté is untempered. Petty said any interpretation which treats the text as future prediction " is fatally flawed from the start." The flaw is not merely(!) to misinterpret the genre. The fatal flaw is to cut ourselves off from the church's experience of God. It is to ignore our memory and our witness that by endurance we possess our lives. We ignore the gift of God.


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Meet Sango, America's Hardest Working Producer
At just 26, Kai Asa Savon Wright has a total of 17 releases -- and he just became a father
By Rutger Rosenborg
Published May 4, 2018 at 9:00 AM
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Courtesy of Sango
Sango headlines Observatory North Park on May 23.
"She was like a demon slayer, and I thought that was fire," Seattle-based electronic, hip-hop and R&B producer Kai Asa Savon Wright told me over the phone last month.
Wright, better known by his stage name Sango, was talking about an eponymous supporting character from the anime series "Inuyasha."
"[The name Sango] comes from this cartoon, this anime I used to watch, 'Inuyasha.' It's the name of one of the female characters," he said.
While Wright was born in Washington, he spent 13 years in Michigan, a state whose identity has largely been characterized by its hard-working, blue-collar ethos. While there, he studied graphic design at Western Michigan University and really only moved to back to his birth state for family reasons.
Having honed both the visual and aural aspects of Sango during his time in Michigan, Wright set about separating himself from the pack, releasing 14 EPs, two studio albums and one mixtape in a span of only eight years.
"At that point in time, I was trying to like make it. I had to put a lot of content out ... [because] I wanted to be an artist that is also a producer. If you release that much, people are going to realize, 'Oh, this guy's for real,'" Wright said.
His latest effort -- made all the more impressive because he's now married and a father to a toddler -- is his second studio album, "In the Comfort Of," which features the mystifying single, "Sweet Holy Honey."
"Xavier Omar [guest vocalist] and I, we sat down and I was like, 'Man, I want to write a song about a topic that's never done before,'" Wright told me.
"The source of the idea was deciding to not have sex in a relationship. My wife and I, at the time we were dating, we decided not to have sex," he added.
Obviously, that's since changed. Wright and his wife, Angela Lopez-Wright, welcomed Mateo Wright into the world on Sept. 17, 2016.
"It's affected it [his life] a lot. I have to be attentive; I have to be alert -- you know, daddy duty," Wright said.
As for the effect of fatherhood on his music?
"Quality goes up, but the quantity goes down. I'm just really glad that I started producing at a young age," he responded.
In the Comfort Of by Sango
Wright is only 26 years old, and already he seems to be approaching some semblance of comfort with his creative career. After eight years of hard work, he's found a rhythm.
Now, Sango's turning outward, asking his audience: "What in your life are you most comfortable about and what are you least comfortable about, and how can we have a conversation about that through music?"
Sango headlines Observatory North Park on May 23. Get tickets here.
Rutger Ansley Rosenborg has been an Associate Editor at NBC SoundDiego since 2016. Find out more here, or contact him here.


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Child's death sparks debate about media ethics
IT is the evening of July 22 and private broadcaster TV Markíza launches its news. Right from the beginning special clip shows pictures of a car exposed to the sun's rays as the newscaster informs about the death of a 2-year-old girl left inside by her father.
"The mother who came to the place collapsed and father is in bad psychological condition," TV Markíza reporter Dana Brixová said, as quoted by the Denník N daily. "Let's see the clip where you will see the father, mother and their neighbor who called police."
Markíza then broadcasts the report in which Brixová approaches a stunned mother unable to speak. "How could this happen?," the reporter asks. The mother does not respond and is later escorted away by her husband. Brixová follows the couple for a while but asks no further questions. Markíza also captured moment when another reporter, from rival TV JOJ, tried to interview the mother but stopped with comment: "You probably won't speak about it, right?"
The state-run Council for Broadcasting and Retransmission (RVR), which deals with ethics issues of electronic media, received 26 complaints over those reports. People mostly complained about violating of parents' human dignity, RVR spokeswoman Lucia Jelčová told The Slovak Spectator.
Police investigate
The child was found dead in a black car that was parked on Janko Kráľ Street in Nitra at around 14:30 when the temperature in the shade was reaching 36 degrees Celsius. The police have not said how long the girl was left in the car, though it seems several hours.
She was abandoned by her 57-year-old father Jozef who was supposed to take his daughter to the nursery but forgot that she was in the car, according to Sme daily website.
"According to the coroner, the probable cause of death was overheating of the organism. The body of the little girl was taken to a hospital, where an autopsy will be carried out," Nitra regional police spokeswoman Božena Bruchterová told the TASR newswire on July 23.
The younger children are the sooner they collapse, according to Peter Visolajský, the head of Doctors Trade Union Association (LOZ) and doctor from Nitra Faculty Hospital.
"There are burn injuries on parts of body exposed to direct sun," Visolajský said, as quoted by Sme. "The overall overheat of the organism could lead to cerebral oedema and subsequent death."
Police initially investigated the case as criminal act of abandoning child which could be punished by seven to 12 years of imprisonment. Later it accused father of criminal manslaughter with the possible punishment from two to five years in prison, the daily reported.
"This big tragedy should be lesson to all of us," reads a police statement. "We often forget what is the most precious for us in this hasty world."
The way of reporting
The report of TV Markíza and TV JOJ enraged numerous people including some politicians questioning the motives of the broadcaster when approaching mother.
"What do reporters and their bosses - who allow or order them to ask such question - expect?" Veronika Pizano, the assistant professor at Faculty of Mass Media Communication at University of Cyril and Methodius in Trnava asked in her blog. "That a mother will say them how terrible it is that her child just died? What is the benefit of asking such questions for the viewer?"
She criticised also the private broadcaster TV JOJ for its similar approach.
The head of news department of the broadcaster Henrich Krejča backed the report saying that it is duty of reporter to publish authentic picture of the scene. The reporter's motivation was not abusing of emotion rather the hunting for facts, Krejča said, according to the Denník N daily.
"We are visual medium," Krejča told the daily. "A print reporter is fine with statement that other side refused to comment the case. We should show it by picture and voice."
Markíza's and JOJ's reports however misuse emotions by using dramatic graphics, sounds and editing, according to Pizano. They provided no information how to prevent such tragedies and did not bring the opinion of professional who would explain that such tragedies have happened in past because of daily routine and stress.
She highlighted the fact that Denník N published the story "Fatal Distraction: Forgetting a Child in the Backseat of a Car Is a Horrifying Mistake" published by The Washington Post on June 16, 2014. It brings stories of several parents who left their child in car and explain why it could happen to anyone.
Ability to respond
The aim of the reporter was to learn as much as possible about what actually happened and Brixová, who is actually a mother of small child, did not violate ethical rules, according to Krejča.
"The reporter asked one question and after not being answered she did not continue," Krejča told Denník N. "We are the news. When information changes every minute some relative has to confirm or refute them. We have to give space to each side."
It is pointless to ask questions relatives of victims right after they learn about tragedy, according to Radovan Bránik, the head of crisis team Modrý anjel (Blue Angel), which assists during accidents.
"Journalist will find out nothing," Bránik told Denník N. "At this time the close person of victim is not able to fully understand what happened."
Media covering of such tragedies should be part of journalism but it should focus on context and causes of such happenings not pictures mourning relatives, he said.
"The medium won't find truth in this way," Bránik told Denník N. "It only gets pictures which can make people cry."
On the other hand, media will not significantly hurt people by doing this because relatives are so overwhelmed by emotions that they forget that journalists approached them few minutes after they tried, he added.
Tragedies and society
Media should stop using the argument that people want to see tragedies. People are curious and open to emotional reporting however such reports make them even more dull so they want even more tragic ones. This is how people's brain works, according to Pizano.
Interviews by journalists with victims or their relatives are often reported to RVR by their family. It is sensitive for them and they complain however most complaints are related to volumes of advertisement and child protection, according to Jelčová.
It is clear that broadcasters do not care about this issue therefore it should be viewer who gives feedback that such an approach is unacceptable, according to Pizano.
"Let's stop watching broadcasters and their news," Pizano writes. "Let's start to intentionally draw information which is really important for our society."
5. Aug 2015 at 11:13 | Roman Cuprik


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TSX-V: AAL 0.33 | OTCQX: AVLIF 0.26
Advantage Lithium Corp. Files Pre-Feasibility Technical Report For Its Cauchari JV Project, Argentina 29 November 2019
Orocobre Partnership
Cauchari JV
Exploration Properties
Pre-Feasibility Study
Statutory Reports
Advantage Lithium Corp. Files Pre-Feasibility Technical Report For Its Cauchari JV Project, Argentina
Further to the News Release of October 22nd 2019, Advantage Lithium Corp. (TSX Venture AAL) ("Advantage" or the "Company") is pleased to announce that it has filed the full Pre-Feasibility ("PFS") Technical Report on its Cauchari JV project located in Jujuy Province, Argentina.
The PFS was completed by independent consulting firms FloSolution and Worley and may be accessed on the Canadian Sedar site under Public Documents.
To find out more about Advantage Lithium Corp. please contact the company at (604) 423-4499 or by email at [email protected]
ADVANTAGE LITHIUM CORP.
Per: "Callum Grant"
Callum Grant, Interim CEO
Tel: 604.423.4499 | Fax: 604.423.4498
About Advantage Lithium Corp.
Advantage Lithium Corp is focused on developing its 75% owned Cauchari lithium project, located in Jujuy Province, Argentina. The Company also owns 100% interest in additional and prospective lithium exploration properties in Argentina: Antofalla, Incahuasi, and Guayatayoc having a combined area of ~72,000ha. The Company is headquartered in Vancouver, British Columbia and trades on the TSX Venture Exchange (TSX-V: AAL) and the OTCQX Best Market in the U.S. (OTCQX: AVLIF).
Further information about the Company can be found at www.advantagelithium.com.
Cautionary Statement:
Certain information contained in this press release constitutes "forward-looking information", within the meaning of Canadian legislation. Generally, these forward-looking statements can be identified by the use of forward-looking terminology such as "is expected", "intends", or "has the potential to". Forward looking statements contained in this press release may include statements regarding the future operating or financial performance of Advantage that involve known and unknown risks and uncertainties which may not prove to be accurate. Actual results and outcomes may differ materially from what is expressed or forecasted in these forward-looking statements. Such statements are qualified in their entirety by the inherent risks and uncertainties surrounding future expectations. The forward-looking statements included in this press release are made as of the date of this press release and the Company disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as expressly required by applicable securities legislation.
Introducing Advantage Lithium
Advantage Lithium is a lithium explorer and developer with top tier management and an international portfolio of quality assets. The Company has a partnership with Orocobre - one of Argentina's leading lithium producers - to develop its Cauchari JV asset, which hosts an inferred resource and includes a large exploration target. Orocobre is the largest single shareholder of Advantage Lithium.
The Advantage Lithium team has a track record of making discoveries and building companies and, having launched in July 2016, the Company has hit a series of major milestones in a very short space of time. Advantage Lithium is listed on the TSX Venture Exchange under the symbol AAL.
Advantage Lithium
The Advantage Lithium Management and technical teams have a track record of success and of growing investor wealth.
TSX-V: AAL Change -0.01 | Last 0.33 OTCQX: AVLIF Change +0.00 | Last 0.26
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"He was one of the first people to get into the computer control of radios, and he has become a big guy in that."
A southeast Shreveport businessman has a wide-ranging business you might pass on a daily basis and never notice.
James Springer has run Computer Aided Technologies from his Southern Hills home since the late 1980s. It's almost completely Internet based. The only evidence of his passion and work is a room crammed with computers, radios, scanners, scopes and test equipment, largely rigged together with a nerve network of cables and wires.
"We write software," said Springer, 67, the father of two grown children and the grandfather of four. "That's the principal source of our sales."
His major product is Scancat, perhaps the standard for the computer programming of base and portable radio scanners used by the public, law professionals, the military and other government agencies. The spreadsheet-style program turns the tedious chore of programming scanners with frequencies, text identifiers and trunking codes needed to make them work right.
"His motto for Scancat is 'Once you use it you'll never use the keypad to program your radio again,' which is really true," said John Shidler, owner of the Shreveport private detective firm All the Facts Investigations.
"It's a very esoteric market, small but worldwide, locally produced and sold all over the world. He was one of the first people to get into the computer control of radios and he has become a big guy in that."
Ohioan Springer moved to Shreveport in 1967 and sold magazines, insurance and electronics supplies before settling in for a 15-year stint at the industrial supplier WW Grainger. While there, at the suggestion of a friend, he developed his scanning program, with sales beginning in 1989.
About four years ago, Radio Shack started using Scancat to program its scanners, something Springer says has caused his business to grow.
"Around 70 percent of our sales are now from Radio Shack," he said. "We do six figures. I won't say which side of the range we're on, though."
Another product is Copycat, a program targeted at ham and shortwave radio operators and also caters to many military and professional clients.
"We don't have competition," Springer said of his programs, which he constantly upgrades to keep up with changes in the radios. "It's a niche market."
He also is a national reseller of Hoka, a software suite from the Netherlands that allows high frequency and VHF radio digital signals analysis.
"We're a vendor and sell that product to government people, people in agencies with three letters in Maryland," he said. "Only 1 in 50 sales goes to a hobbyist."
His next product, Springloader, is about as far from programming as you can get, a plastic assembly that allows fast and easy reloading of clips for semiautomatic pistols.
"It's for avid gun shooters, people who go to the range, law enforcement," he said. "In fact, it's targeted at a lot of the same people who might use Scancat."
The work doesn't faze Alicia, his patient wife of close to 40 years.
"Huh," she said with a smile as he showed off his new creation. "I just ignore him."
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Red is such a flamboyant color. I adore red lipstick, but don't own a red piece of garment. It looks terrible on me. But the lipstick…ah the lipstick is so bold. It puts you out there and you need to be a confident woman wearing it with ease. Red color in jewelry is just as sassy as the red lipstick is. It's kind of loud and out there. But so very charming and intriguing at the same time. And for those of you who like to be on trend: it's a shade of red, Marsala, that is thé color of 2015!


text:
#PublicationDay ~ Saving Mr Scrooge is out today!
On November 14, 2017 November 13, 2017 By sharon
Novel number nine, Saving Mr Scrooge, is published today, and I'm quite relieved about it! It seems to have taken forever to get this book ready, but then, I did dream up the title nearly two years ago, and so I seem to have been living with my own dear Mr Scrooge for a long time.
The title is usually the last thing to occur to me, but with my Moorland Heroes series, the titles came first. Saving Mr Scrooge was the first one to pop into my head. I'd been on the point of falling asleep when it arrived, and it made me sit up in bed, suddenly wide awake. My own Eureka moment!
I wasn't entirely sure what the story was about, but I knew there was a Scrooge-like character involved, and the woman who would save him would be called Marley, in honour of Jacob Marley. But the more I thought about it, the more I realised that there was more to this story than a simple retelling of A Christmas Carol. No ghosts, for a start. At least, not in the traditional sense. And there would be a twist in the tale, too – and I don't mean Oliver. 🙂
So now my second Moorland Heroes story is out there, following on from Resisting Mr Rochester. I have a third story in the series planned, and I'm looking forward to writing that one, but I won't reveal its title just yet! In the meantime, I really hope you all enjoy Saving Mr Scrooge. Here's the blurb:
It's the time of peace on earth and goodwill to all men, but at Carroll's Confectionary, the meaning of Christmas seems to have been forgotten. New boss, Kit Carroll, is hardly winning friends with his high-handed attitude, his foolhardy approach to production, and his tight-fisted treatment of the factory's employees.
Marley Jacobs, his self-styled PA, is determined to make him see the error of his ways, and return the festive spirit to Carroll's Confectionary.
Unfortunately, the little matter of their previous relationship, along with Kit's callous treatment of her when they were teenage sweethearts, keeps getting in the way of her good intentions.
With encouragement from co-worker Don, romantic sister Olivia, and — astonishingly — the usually sceptical Great Uncle Charles, Marley decides to save this modern-day Mr Scrooge from himself, despite having no well-meaning ghosts to help her.
But revisiting the past doesn't just stir things up for Kit. As Marley struggles to deal with bittersweet memories, present-day events take a surprising turn. Can the future be changed, after all?
And is it only Kit who needs saving?
Saving Mr Scrooge is available to buy here.
chocolateChristmasconfectioneryJacob MarleyMoorland HeroesnovelResisting Mr Rochesterromanceromantic comedySaving Mr Scrooge
Five Photos … with Paula Martin
Guest Post: Getting to Know Pat Posner
4 thoughts on "#PublicationDay ~ Saving Mr Scrooge is out today!"
Carol Warham
This sounds brilliant. I love the sound of your Moorland Heroes, will go and check them out!
Thank you, Carol. Hope you enjoy them. x
November 14, 2017 at 11:58 pm	 Reply
Jan Brigden
Happy Publication Day, Sharon. Off to get my copy! Lovely post! 🙂 Xx
Thank you very much, Jan x


Over 50000 pages are listed in this category provide FREE listing in a user friendly and search engine friendly way. If you want to list your company on the top listing of the page heavy metal band click on GET LISTED NOW for paid listing.
Darkling is an all original hard rock band combining an old school rock-n-roll with a new school heavy edge. Not alternative, not death metal just straight forward in your face rock-n-roll.


Composite image of supernova remnant W49B showing a barrel-shaped nebula.
Kulkarni's studies focus on long duration gamma-ray bursts. These bursts occur when a young massive star burns through its hydrogen core.
"The gamma-ray burst goes off and we use the Keck I telescope to measure its spectrum, which tells how far away it is," said Kulkarni, the John D. and Catherine T. McArthur Professor of Astronomy and Planetary Science at the California Institute of Technology. "Most gamma-ray bursts are very far away, and we believe that they occurred with much greater frequency when the universe was young."
When the pressure generated by this reaction diminishes, the pull of gravity forces the star's matter to collapse in on itself. For some extremely massive stars, the force of the collapse is strong enough to create a black hole and the energy is sufficient to power a massive explosion, resulting in an eruption of energy and light.
Occurring on the very edges of our universe, these stunning explosions create a powerful light source which allows astronomers to gaze deeper into space. Long-duration gamma-ray bursts last for just a few seconds, but the light is sometimes so strong that the 'afterglow' exists for months at a time, illuminating details in space that would have been nearly impossible to see before. This "long-duration class" of illumination is what helps Kulkarni undertake detailed observations with the Keck telescope.
"Gamma-ray bursts are nature's light post, and you can use their luminescence to study everything between the gamma-ray burst and you," added Kulkarni. "If you happen to be there the hour after a gamma-ray burst happens, you can collect more information than you can possibly imagine."
Seventy-five percent of all gamma-ray bursts are in the long-duration class, the soulful death cries of a once massive star. The other 25 percent exist in the short-duration class.
The differences between the two classes raise questions that are driving the research horizons in this field. Kulkarni is hoping to focus next on what differentiates the power between the two types of gamma-ray bursts while also investigating the unknown forces that initiate these galactic marvels.
"How do you decide what to do next?" ponders Kulkarni. "I think most scientists do not take a critical view. It is very easy to keep doing what you're doing, especially when the science questions are interesting. Yet, I believe it is important to assess your work and see if it is worth continuing. You can become a guru of the field, and maybe this is comfortable . . . my life has been pleasantly full because of discoveries I have made. But, by throwing myself into a new area, there is an opportunity to see things differently."
This series of Hubble Space Telescope images shows the likely home of the gamma-ray burster.


Which Side Will You End Up On?
What Is Your Secret Admirer's First Initial?
What Kind Of Good Luck Will You Find?
What Type Of Love Do You Need Right Now?
What Is The ONE Thing That Makes You Irresistible?
What Makes You Hotter Than The Rest?
Where Is Your Soul's Spiritual Home?


If you can trust a person with a very small thing, you can also trust him with bigger things. And if you cannot trust a person with a very small thing, you cannot trust him with big things.
GUT. CHECK. Right? I don't know about you guys, but I constantly sit at the feet of Jesus asking for more. Sure, more money and more things. But also, more relationally, more spiritually, more leadership. Just MORRREEEE.
I don't believe in a God who shames or punishes; so I have to constantly fight off the lies that creep into my mind when I read this verse. It's really easy to let my defensiveness cloud my vision and view this as "God's saying you're not trust-worthy enough". But when I bring my thoughts back to God's character and who He is, I know that's not even close to what this verse is about.
Our God is a God of growth and sanctification. If God doesn't think I can be trusted with something now, that doesn't mean I never will be. In fact, I think it's the opposite. His desire is for us to grow closer to Him so that we become more and more like Jesus. And as we see throughout the entire Bible, there's nothing that Jesus isn't trusted with.
One of the things I've tried to implement this year is that when I find myself wishing or praying for more, I try focus my attention back to what I have.
I want an amazing, larger than life, "This Is Us" kind of marriage. How am I taking care of my real-life, we-have-plenty-of-problems marriage?
I want a blog with thousands of readers. How am I serving the people who already show up here consistently?
I want better skills and more talent in writing, photography, creating, and designing. How am I using the skills I already have to glorify God?
The "wanting more" happens at least ten times a day (thanks to social media), but I just keep this verse on repeat.
And I've I learned that not only is God not shaming me in this verse, He's actually giving me a gift. When I'm given something small, I learn to take care of it. And that process of learning to care for something isn't just so that I can have more; it teaches me discipline and it brings me satisfaction and joy. I think this scripture is the thought behind every cheesy "it's about the journey, not the destination" quote.
If you find yourself facing something big and difficult, remember that God's been preparing you for this with all the small things along the way. And if you're seeking something bigger, never stop praying for those things! But try to find the small things in your life that will help to mold you into the person you'll need to be when you're finally given those big things.
Create a gratitude list for the small (and big) things in your life. How well are you taking care of the things you've been given? How can you better care for the things on your list? Is there anything that isn't on your list that could be with a perspective change?
For the things on your gratitude list. *Remember that prayer can simply be a time for thanksgiving and praise!
Here we go again with this Dash waffle maker – I can't help it, I'm obsessed! And it's changed the breakfast game for me. I wanted a traditional PB&J sandwich when I created this, so I used Justin's Classic Peanut Butter, but you can use any type of nut butter you'd like. Or you can use sunflower seed butter or cookie butter (gasppp) if there's a nut allergy in your house. You can also use a different fruit if you'd like your jam to be strawberry, blackberry, etc.
A lot of people have asked about using a packaged pancake/waffle mix because they're short on time! That's totally fine – remember, this is about what works best for you! While I try to make my own mix as often as possible, I always keep a packaged mix in the pantry in case of emergencies. My absolute favorite is the Birch Benders Paleo.


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Inspired By Nature, I Upcycle Faux Fur Fabric By Sewing It Into Realistic-Looking Animals
I'm Rachel Austin, a textile artist from The Forest of Dean in Gloucestershire. Greatly inspired by nature and my beautiful surroundings, I love the challenge of working out how to cut fabric pieces, which when sewn together and stuffed, form realistic-looking animals....
I'm Rachel Austin, a textile artist from The Forest of Dean in Gloucestershire. Greatly inspired by nature and my beautiful surroundings, I love the challenge of working out how to cut fabric...
Rachel Austin
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Incredibly Lifelike Sculptures By Belgian Artist
Hans Op de Beeck is a Belgian visual artist who is best known for his detailed lifelike monochrome sculptures. The 49-year-old artist lives and works in Brussels, but has had many shows all over the world, including United States Of America, Netherlands,...
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Thanks to digital painting, several artists who previously had no way to show their art for lack of material can now appear and let their gift marvel millions of people through the internet. The only tool they need is a good...
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Beijing artists Sun Yuan and Peng Yu have been known to create installations using real cadavers or human fat tissue, and though their newest creation does not include these macabre parts, it's so realistic and unsettling that it might as well....
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Lee Cross, a talented sculptor from Alaska who also goes by Wood Splitter Lee, has mastered the craft of creating poseable plush animals that look convincingly life-like. Lee is also known for her phenomenal fantasy beasts, which combine her signature believable,...
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The electronic microprocessor mod. F 130 are easily matched to the flow meter series KDN and allow the aggregation of totalisation and predetermination of all fluids up to 40,000 cps. They can be powered trhough 24 Vdc (to be used by apposite special power supply) or by lithium batteries 3.6 V. They are mounted directly on the pipe wall using brackets, directly on the flow meter. Running ATEX certified can be used in hazardous areas. Used to realize practical filling stations drums, also trailerable, thus replacing the traditional scales.


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Q: EF Code First ApplicationUser required DateTime not added
I have a problem registering new users with my new ASP.NET Core Application (Code First).
When registering i'm using an `ApplicationUser` inheriting from `IdentityUser`.
public class ApplicationUser : IdentityUser
{
    [Required]
    [DefaultValue(5)]
    public int ViewerRange { get; set; }
    [DefaultValue(false)]
    [Required]
    public bool IsTACAccepted { get; set; }
    public DateTime? TACAccepted { get; set; }
    [Required]
    [DatabaseGenerated(DatabaseGeneratedOption.Identity)]
    public DateTime Created { get; set; }
    [Required]
    [DatabaseGenerated(DatabaseGeneratedOption.Computed)]
    public DateTime Modified { get; set; }
    public string Role { get; set; }

    public ApplicationUser()
    {
        Modified = DateTime.Now;
        Created = DateTime.Now;
    }
}

Here´s the part of Register.cshtml.cs
public async Task<IActionResult> OnPostAsync(string returnUrl = null)
{
    returnUrl ??= Url.Content("~/");
    ExternalLogins = (await _signInManager.GetExternalAuthenticationSchemesAsync()).ToList();
    if (ModelState.IsValid)
    {
        var user = new ApplicationUser
        {
            UserName = Input.Email,
            Email = Input.Email,
            Role = Input.Role,
            Created = DateTime.Now,
            Modified = DateTime.Now,
            IsTACAccepted = false,
            ViewerRange = 5
        };

        var result = await _userManager.CreateAsync(user, Input.Password);
        //[...]

When registering, the CreateAsync Method fails with the following error:
InvalidOperationException: The value for property 'ApplicationUser.Modified' cannot be set to null because its type is 'System.DateTime' which is not a nullable type.

I can't understand why this is failing.
Can someone explain in detail please?
Kind regards

A: public DateTime? Created { get; set; }
public DateTime? Modified { get; set; }

Use this, your model needs to be told that there can be null values inside your database, otherwise it will assume there aren't.
UPDATE
**I did not actually carefully noticed your error. Now I will update my answer:-**
I see you did not use this property in your controller. so initially this property nullable. for that you found this issue. first of all, use this property to ignore nullable.
Try like this:-
public DateTime TACAccepted { get; set; }  = DateTime.Now;

You can try this because your property it's null. You set this property like the above code for ignoring the nullable. or you remove this property from your model if it's don't need. I think it's will resolve your issue.
Also, make sure that column is declared as a DateTime in your SQL Database.

A: The reason for the error is that [DatabaseGenerated(DatabaseGeneratedOption.Computed)] says its value is generated by the database, so any assigned value should be ignored. The error shows this isn't the case though.
This isn't the only oddity in the code. [DatabaseGenerated(DatabaseGeneratedOption.Identity)] on a DateTime makes no sense. IDENTITY is used to autoincrement numeric fields. This has no meaning for a DateTime column.
f you want to specify the values yourself, remove the DatabaseGenerated attributes and use them as normal fields. You can avoid the explicit assignment by specifying a default property value, eg
public DateTime Created { get; set; } = DateTime.Now;
public DateTime Modified { get; set; } = DateTime.Now;

It's also possible to configure the database to generate those values. This is described in the docs, in the Generated Values article. Adding Created and Modified columns is described in the Date/time generation section.
A default value constraint for the Created column can be specified with HasDefaultValueSql :
protected override void OnModelCreating(ModelBuilder modelBuilder)
{
    modelBuilder.Entity<Blog>()
        .Property(b => b.Created)
        .HasDefaultValueSql("getdate()");
}

The Modified timestamp needs a trigger though, which can't be specified in a DbContext's model. This must be created in the database, either directly :
CREATE TRIGGER [dbo].[Blogs_UPDATE] ON [dbo].[Blogs]
    AFTER UPDATE
AS
BEGIN
    SET NOCOUNT ON;

    IF ((SELECT TRIGGER_NESTLEVEL()) > 1) RETURN;

    DECLARE @Id INT

    SELECT @Id = INSERTED.BlogId
    FROM INSERTED

    UPDATE dbo.Blogs
    SET LastUpdated = GETDATE()
    WHERE BlogId = @Id
END

Or through a raw SQL migration that executes the same script :
migrationBuilder.Sql(
@"
    EXEC ('CREATE TRIGGER [dbo].[Blogs_UPDATE] ON [dbo].[Blogs]
    AFTER UPDATE
AS
BEGIN
    SET NOCOUNT ON;

    IF ((SELECT TRIGGER_NESTLEVEL()) > 1) RETURN;

    DECLARE @Id INT

    SELECT @Id = INSERTED.BlogId
    FROM INSERTED

    UPDATE dbo.Blogs
    SET LastUpdated = GETDATE()
    WHERE BlogId = @Id
END')");

redpajama_set_name: RedPajamaStackExchange


Jet air dryers have become increasingly popular over the past decade, as they are perceived as being more environmentally friendly. But few who use them realize that they are dirty, germier and far less hygienic than most people know. The objective of this project is to refocus the conversation to hand hygiene over sustainability. By personifying both paper towels and jet air dryers, we're establishing the inherent negative qualities of the jet air dryer, emphasizing that they are irresponsible, and showing that paper towels are the safer choice. Educating people to the dangers of their use and encouraging them to do the responsible thing by choosing the safer alternative.


text:
Aucubin
Product Name Aucubin
Molecular Weight: 346.33 g/mol
Type of Compound: Iridoids
Physical Desc.: White powder
Targets: MMP(e.g.TIMP) | NOS | COX | NO | IL Receptor | NF-kB | TNF-α | ERK | IkB | ROS | HBV | DNA/RNA Synthesis | IKK
Source: The herbs of Galium aparine L.
Aucubin is an iridoid glycoside with a wide range of biological activities, including pancreas-protective, chondroprotective, antispasmodic, liver-protective, anti-inflammatory, anti-microbial, antioxidant, anti-algesic as well as anti-tumor activities. Aucubin prevents neuronal death in the hippocampal CA1 region in rats with diabetic encephalopathy, it also has protective effects on H2O2-induced apoptosis in PC12 cells. Aucubin may improve obesity-induced atherosclerosis by attenuating TNF-α-induced inflammatory responses. Aucubin suppresses hepatitis B viral DNA replication in vitro.
Evidence-Based Complementary & Alternative Med.2017
Chem Biol Interact. 2016 Oct 25
Cell Physiol Biochem. 2017;44(4);
J Ethnopharmacol.2016 Jun 25.
Semyung UniversityJan. 2017;
Yakugaku Zasshi.2018 Jan 30;
Oncotarget. 2017 Jun 28;
Clin Exp Pharmacol Physiol.2015 Aug 1
Biochem Systematics and EcologyOctober 2017;
Industrial Crops and Products2017 Jan.
CAS No: 479-98-1
6-O-p-Hydroxybenzoylaucubin
Agnuside
10-O-Vanilloylaucubin
Rhmannioside D
Exp Neurobiol. 2014 Sep;23(3):238-45.
Aucubin promotes neurite outgrowth in neural stem cells and axonal regeneration in sciatic nerves.[Pubmed: 25258571]
Aucubin is an iridoid glycoside with a wide range of biological activities, including anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities. Recently, it has been shown that Aucubin prevents neuronal death in the hippocampal CA1 region in rats with diabetic encephalopathy. In addition, it has protective effects on H2O2-induced apoptosis in PC12 cells.
We have shown here that Aucubin promotes neuronal differentiation and neurite outgrowth in neural stem cells cultured primarily from the rat embryonic hippocampus. We also investigated whether Aucubin facilitates axonal elongation in the injured peripheral nervous system. Aucubin promoted lengthening and thickness of axons and re-myelination at 3 weeks after sciatic nerve injury.
These results indicate that administration of Aucubin improved nerve regeneration in the rat model of sciatic nerve injury, suggesting that Aucubin may be a useful therapeutic compound for the human peripheral nervous system after various nerve injuries.
Cytokine. 2013 Jun;62(3):407-12.
Aucubin, a naturally occurring iridoid glycoside inhibits TNF-α-induced inflammatory responses through suppression of NF-κB activation in 3T3-L1 adipocytes.[Pubmed: 23612013]
Obesity is closely associated with a state of chronic, low-grade inflammation characterized by abnormal cytokine production and activation of inflammatory signaling pathways in adipose tissue. Tumor necrosis factor (TNF)-α is chronically elevated in adipose tissues of obese rodents and humans. Increased levels of TNF-α are implicated in the induction of atherogenic adipokines, such as plasminogen activator inhibitor (PAI)-1, adipose-tissue-derived monocyte chemoattractant protein (MCP)-1, and interleukin (IL)-6. Aucubin, an iridoid glycoside existing in medicinal plants, has been reported to show an anti-inflammatory activity by suppression of TNF-α production in murine macrophages.
The present study is aimed to investigate the effects of Aucubin on TNF-α-induced atherogenic changes of the adipokines in differentiated 3T3-L1 cells. Aucubin significantly inhibited TNF-α-induced secretion and mRNA synthesis of the atherogenic adipokines including PAI-1, MCP-1, and IL-6. Further investigation of the molecular mechanism revealed that pretreatment with Aucubin suppressed extracellular signal-regulated kinase (ERK) activation, inhibitory kappa Bα (IκBα) degradation, and subsequent nuclear factor kappa B (NF-κB) activation.
These findings suggest that Aucubin may improve obesity-induced atherosclerosis by attenuating TNF-α-induced inflammatory responses.
Res Commun Mol Pathol Pharmacol. 1998 Nov;102(2):189-204.
Liver-protective activities of aucubin derived from traditional oriental medicine.[Pubmed: 10100510]
The iridoid glycosides including Aucubin (AU), catalpol (CA), swertimarin (SW), and gardenoside (GA) are frequently found as natural constituents of many traditional oriental medicinal plants including Chinese herbs. Among these iridoid glycosides, AU was systematically studied for its potent liver-protective activities using experimental systems of hepatic damage. AU showed high liver-protective activity against carbon tetrachloride-induced hepatic damage in mice. Also AU showed significant protective activity against alpha-amanitin-induced hepatic damage in mice, and it prevented a depression of liver RNA biosynthesis caused by alpha-amanitin administration. Potent antidotal effects on mushroom poisoning in beagle dogs ingested with aqueous extract of Amanita virosa was observed; beagle dogs completely survived, even when AU administration was withheld for half an hour after mushroom poisoning. In addition, AU was found to suppress hepatitis B viral DNA replication in vitro. Conversion of AU to its aglycone form appeared to be a prerequisite step for an exhibition of such antiviral activity.
Int Immunopharmacol. 2015 Feb;24(2):408-15.
Aucubin prevents interleukin-1 beta induced inflammation and cartilage matrix degradation via inhibition of NF-κB signaling pathway in rat articular chondrocytes.[Pubmed: 25576403]
Proinflammatory cytokine interleukin-1β (IL-1β) plays a crucial role in the pathogenesis of Osteoarthritis (OA) by stimulating several mediators contributed to cartilage degradation. Aucubin, a natural compound derived from plants which has been shown to possess diverse biological activities including anti-inflammatory property, may benefit the IL-1β stimulated chondrocytes.
The present study was aimed to investigate the effects of Aucubin on IL-1β stimulated rat chondrocytes. Rat chondrocytes were cultured and pretreated with Aucubin (1, 10, 20, 50μM), and then stimulated with or without IL-1β (10ng/ml). Gene and protein expression of MMP-3, MMP-9, MMP-13, cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) was determined by real-time PCR and Western blotting respectively. Nitric oxide (NO) production was quantified by Griess reagent. Phosphorylation and nuclear translocation of p65 were detected by western blotting and immunofluorescence, respectively. We found that Aucubin significantly reversed the elevated gene and protein expression of MMP-3, MMP-9, MMP-13, iNOS, COX-2 and the production of NO induced by IL-1β challenge in rat chondrocytes. Furthermore, Aucubin was able to suppress the IL-1β-mediated phosphorylation and nuclear translocation of p65, indicating Aucubin may possibly act via the NF-κB signaling pathway.
The present study proposes that Aucubin may be a potential therapeutic choice in the treatment of OA due to its anti-inflammatory and chondroprotective features.
Planta Med. 1994 Dec;60(6):512-5.
In vitro antispasmodic activity of peracetylated penstemonoside, aucubin and catalpol.[Pubmed: 7809202]
In vitro, the peracetates of penstemonoside, Aucubin and catalpol, iridoids isolated from Parentucellia latifolia, antagonize the uterine muscular contractions induced by acetylcholine and calcium, in a similar way to papaverine.
The antagonism is non-competitive against acetylcholine (pD2' values: 5.60 for the peracetates of penstemonoside, 5.74 for Aucubin, 5.59 for catalpol, and 5.32 for papaverine) and competitive against calcium (pA2 values: 6.60 for the peracetates of penstemonoside, 6.34 for Aucubin, 6.48 for catalpol, and 6.23 for papaverine). The two components, phasic and tonic, of the response of the vas deferens to potassium are reduced by the three iridoids.
The reduction is similar for both phases. The antispasmodic activity of the three iridoids, similar to papaverine, is related to an inhibiting effect of extracellular calcium, intracellular or both.
Cell Research
Biol Pharm Bull. 2005 Jul;28(7):1244-8.
Protective effects of aucubin isolated from Eucommia ulmoides against UVB-induced oxidative stress in human skin fibroblasts.[Pubmed: 15997107]
Ultraviolet-B (UVB) irradiation has been demonstrated to produce reactive oxygen species (ROS) in the cells and skin, which induces the synthesis of matrix metalloproteinases (MMPs), causing skin photoaging.
Using the human skin fibroblast HS68 cell line in the present study, we investigated the photoprotective effects of Aucubin from Eucommia ulmoides. Pretreatment with Aucubin significantly inhibited the production of MMP-1 by 57% when compared to the UVB-irradiated cells. Additionally, the senescence-associated beta-galactosidase (SA beta-gal) activity was markedly decreased in the presence of Aucubin, which indicates it as an antiphoto-induced aging compound. As the effect of Aucubin was determined against ROS, the inhibited ROS formation and malondialdehyde (MDA) levels, and the increased cell viability and glutathione (GSH) level were observed with Aucubin under UVB irradiation.
Based upon these results, it was suggested that Aucubin might play an important role in the cellular defense mechanism against UV radiation-induced photoaging. An understanding of the antioxidant properties of Aucubin could, in part, act to elucidate its protective mechanism on the human skin photoaging.
Eur J Pharmacol. 2008 Mar 17;582(1-3):162-7.
Antioxidant and pancreas-protective effect of aucubin on rats with streptozotocin-induced diabetes.[Pubmed: 18230397]
Oxidative stress has been suggested as a contributory factor in development and complication of diabetes. The aim of the present study was to determine the protective effect of Aucubin on lipid peroxidation and activities of antioxidant defense systems and to conduct immunohistochemical evaluation of pancreas in streptozotocin-induced diabetic rats.
Lipid peroxidation was determined by assessing the concentration of malondialdehyde and activities of antioxidant enzymes - catalase, glutathione peroxidase and superoxide dismutase in liver and kidneys of rats were determined. Changes of blood glucose and immunohistochemical evaluation on pancreas were also investigated as part of the pathology of diabetes. In our study, Aucubin treatment lowered blood glucose. Diabetic rats exhibited an increase in the level of lipid peroxidation and decrease in activities of antioxidant enzymes in liver and kidneys as compared to control rats. Administration of Aucubin to diabetic rats for 15 days significantly reversed damage associated with diabetes. In addition, diabetic rats showed an obvious decrease in insulin immunoreactivity and the number of beta cells in pancreas, but the pancreas of Aucubin-treated rats were improved and the number of immunoreactive beta cells were significantly increased.
These results indicated that Aucubin may have value as a safe preventive or therapeutic agent against diabetes mellitus.
Biol Pharm Bull. 1998 Dec;21(12):1306-10.
The promoting effects of geniposidic acid and aucubin in Eucommia ulmoides Oliver leaves on collagen synthesis.[Pubmed: 9881644]
We have reported that collagen synthesis was stimulated by the administration of a hot water extract from the leaves of Eucommia ulmoides OLIVER, Eucommiaceae (Du-Zhong leaves) in false aged model rats.
In this paper, we set out to examine the compounds in Du-Zhong leaves that stimulated collagen synthesis in false aged model rats. In experiment 1, a methanol extract of Du-Zhong leaves also stimulated collagen synthesis in aged model rats. An acetone fraction was derived from the methanol extract by silica gel chromatography in experiment 2. The acetone fraction mainly contained iridoides mono-glycosides such as geniposidic acid and Aucubin. The administration of geniposidic acid or Aucubin stimulated collagen synthesis in aged model rats in experiments 3 and 4 (significance (p<0.05)).
The reported pharmacological effects of Du-Zhong leaves, including healing organs and strengthening bone and muscle, are closely related to collagen metabolism. It appears that geniposidic acid and Aucubin are the actual compounds in Du-Zhong which caused the effect in our experiments.
Ganoderic acid DM
Astragalin
Acetylshikonin
Vicenin -2
Isoliquiritin apioside
Oroselol
Methylnissolin
3-Methoxyshancigusin I
CAS No: N/A
Dihydrolicoisoflavone


Labor Day – Writer/director Jason Reitman's drama starring Kate Winslet and Josh Brolin will hit theaters in limited release on December 25th of this year (just in time for awards season, natch), before expanding wide on January 31st.
Exodus – Director Ridley Scott's Biblical epic about the life of Moses has been dated for a prime holiday release of December 12, 2014, confirming that this will indeed be Scott's next project. Christian Bale may star.
Assassin's Creed – The feature film adaptation of the popular video game series has been dated for Memorial Day weekend of 2015, with a firm May 22, 2015 release date. Michael Fassbender is producing the film and will also star.
Hit the jump for much more on all of the aforementioned projects.
All release dates come courtesy of Box Office Mojo.
Juno and Up in the Air director Jason Reitman's follow-up to 2011's Young Adult finally arrives later this year. Based on the Joyce Manard book of the same name, Labor Day centers on a 13-year-old boy who convinces his reclusive mother to take in a drifter over Labor Day weekend. It's later revealed that the man is an escaped convict and the three spend a weekend together that will shape them for the rest of their lives. Kate Winslet plays the mother, Josh Brolin plays the convict, and the cast is rounded out by that likes of Toby Maguire, JK Simmons, Clark Gregg, and James Van Der Beek. This is an awards contender for sure, and I'm eager to catch the performances and interplay between Winslet and Brolin.
While dueling Moses projects had been moving forward recently at Warner Bros. and 20th Century Fox, the Warner Bros. project (Gods and Kings) was dealt a blow when Steven Spielberg opted not to direct. Now it appears that Fox is moving full speed ahead with Exodus, as Ridley Scott's epic has been given a firm holiday/awards season release date for next year. Last we heard, Christian Bale was being courted for the Moses role. The actor has yet to officially sign on, but as Scott finishes up post-production on The Counselor and starts prepping Exodus for production later this year, we should start hearing much more about this project soon.
Exodus has a script by Oscar-winning scribe Steven Zaillian (Schindler's List, The Girl with the Dragon Tattoo). The film is currently the only movie dated for the December 12th weekend, but Peter Jackson's trilogy capper The Hobbit: There and Back Again arrives the following week.
As for Assassin's Creed, we don't know much about the film project at this time but it almost certainly has a greenlight as New Regency and Ubisoft have set a Memorial Day weekend 2015 release date, notably the same weekend that launched the Pirates of the Caribbean franchise. Michael Fassbender is toplining the project and producing alongside Ubisoft, and acclaimed English playwright Michael Lesslie was recently tapped to pen the screenplay. It'll be interesting to see if the film apes specific storylines from the game series or if Lesslie will be carving out a wholly new tale set in the Assassin's Creed world. The only other film currently slated for release in May 2015 is The Avengers 2, which opens on May 1st.