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Coracoclavicular Ligament
Anatomy ▶ Upper Limb ▶ Joints ▶ Coracoclavicular Ligament
Palpation and Examination
The coracoclavicular ligament is in fact two ligaments, the trapezoid and the conoid. The trapezoid and the conoid ligaments have identical dimensional, viscoelastic behavioral and structural characteristics, regardless of their morphologic differences. It plays an important function in sustaining the integrity of the joint however lies little far from the joint itself.
The coracoclavicular ligament includes two parts:
Conoid.
Trapezoid, which are combined posteriorly and often separated by a bursa.
The conoid ligament is an inverted cone-shaped fibrous band. Base is connected to the conoid tubercle on the inferior surface of the clavicle and the apex is attached to the root of the coracoid process just lateral to the scapular notch.
The trapezoid ligament stretches from upper surface of the coracoid process to the trapezoid line on the inferior surface of lateral end of the clavicle and is a horizontal fibrous band.
Suspending the weight of the scapula and upper limb from clavicle is largely responsiblility of the coracoclavicular ligament.
The coracoclavicular ligament is the strongest ligament of the upper limb.
Both of these ligaments connect to the superior element of the angular region of the coracoid process.
Via a more anterior and lateral position that starts at the angle of the coracoid, ends posterior to the pectoralis minor tendon attachment and courses in the direction of its tip, the trapezoid ligament is oriented toward the clavicle in a superior, anterior, and moderately lateral direction to attach at the trapezoid line on the inferior clavicle.
The conoid ligament expands in area as it runs superiorly and moderately medially toward its point of insertion, the conoid tubercle, from a more posterior and medial site on the angle.
At the curve's apex the conoid tubercle can be recognized on the posteroinferior clavicle, just posteriorand medial to the most medial element of the trapezoid line, now the lateral one third and medial two thirds of the clavicle join to create the posterior curve of the clavicle.
On the lateral element of the more horizontal part of the coracoid is the connection of the coracoacromial ligament distal to the angle. It joins onto nearly the entire width of the acromion process at its anteroinferior edge.
The coracoclavicular ligament assists to link scapulohumeral activity and scapulothoracic activity, by the way of its attachments to the clavicle and scapula, and their respective connection to the axial skeleton and upper body.
These two ligaments create a much stronger union of the clavicle to the scapula than the acromioclavicular ligaments.
This ensures that the clavicle and scapula will move simultaneously, signifying the limits of the natural excursion of the acromioclavicular joint, as the acromioclavicular ligaments reach maximum stress.
In the presence of an intact coracoclavicular ligament, the functional strength of the acromioclavicular joint increases.
Thus, the effective suspension of the upper limb from the torso via the sternoclavicular joint and supporting musculature is ensured.
The function of the acromioclavicular and coracoclavicular ligaments as anterior-to-posterior and superior-to-inferior stabilizers, respectively, displacement resistance of the lateral clavicle is significantly more complex.
The primary restraint comes from the conoid portion of the coracoclavicular ligament.
At all loads, the primary restraint to posterior clavicular displacement is provided by the acromioclavicular ligaments.
Whereas the conoid ligament gives resistance to the larger loads, For superior displacements, once again with smaller loads, the acromioclavicular ligaments give restraint.
Nonetheless, with posterior rotation, the acromioclavicular ligaments and both coracoclavicular ligaments appear to contribute similarly. The conoid ligament also gives the primary restraint to anterior clavicular rotation.
the conoid ligament mainly resists the larger loads and afterwards both the acromioclavicular and conoid ligaments provide combined resistance to small loads in superior clavicular rotation,.
Eventually, the trapezoid part of the coracoclavicular ligament gives the primary resistance, with axial joint compression.
The examiner supports the clavicle while pulling the inferior angle of the scapula away from the chest wall. The trapezoid portion of the ligament might be evaluated from the same position. The stability of the conoid portion of the coracoclavicular ligament might be evaluated by positioning the patient in a side lying position on the untouched side with the hand resting against the lower back. The inspector supports the clavicle and pulls the medial border of the scapula far from the chest wall. Pain in either case in the space of the ligament (anteriorly under the clavicle between the outer one-third and inner two-thirds) constitutes a favorable test.


The TI-84 Plus graphing calculator offers three times the memory, more than twice the speed and a higher contrast screen than the TI-83 Plus model. It's keystroke-for-keystroke compatible, too.Count on TI calculators at exam time. You can use this TI graphing calculator on the PSAT, SAT, and ACT college entrance exams and AP tests and the IB exam.


With its old school charm, beautiful neoclassical architecture, and pretty parks, Munich is the perfect place for a romantic break. From cocktails and dancing to naked sunbathing, step off the tourist track, put down the beer and do something a bit different with our suggestions to make your time together in Munich extra special.
Smaller than its famous cousin the English Garden, you'll find this park in the southwest of the city, about 10 minutes on the U-Bahn from Marienplatz. Often overlooked by tourists, it's the perfect spot for strolling hand-in-hand around the lake. Tucked away in this picturesque park you'll find a Japanese garden, a Thai temple, and even an outdoor cinema in summer. Pop to a local bakery then buy some steckerlfisch from the little stall near the beer garden to create a delicious impromptu picnic.
Preßburger Str. 19, 81377 München, Germany.
The latest craze for dining in the dark has hit Munich too with the opening of Zum Blinden Engel. All dinners arrive for a 7pm start and are led into the pitch-black dining room by one of the "angels" – blind or visually-impaired waiters that help guide guests around the space. There's a set menu for €49.60 without drinks, and you can choose meat, fish, vegetarian, or surprise! The whole evening lasts around 2.5–3 hours, and you'll find Zum Blinden Engel in the Wirtshaus zum Isartal.
Brudermühlstraße 2, 81371 München, Germany, +49 89 74688556.
Think you have the same taste? You're spoilt for choice with the many different museums in Munich, particularly for modern art. To see contemporary classics by Damien Hirst, Joseph Beuys, and Andy Warhol, including his "Marilyn" portrait, head to Museum Brandhorst. This distinctive building opened its doors in 2009. Rather than packing the hyper modern gallery full of exhibits, the museum has wide open rooms with vast white walls. Make the most of €1 entry on Sundays, and avoid Mondays when the Brandhorst is closed.
Theresienstraße 35a, 80333 München, Germany.
Germans are not afraid to bare all. In fact, Munich has six "designated urban naked zones"! You might think these would be tucked away somewhere or fenced off, but no – take the wrong turn in the English garden and you'll find yourself seeing a whole lot more of Germany. If you can't beat them… join them! There aren't many cities in the world where you can go au naturel. You'll find the other naked zones along the Isar River.
Like the thought of being serenaded by a world-class pianist while sipping cocktails? Head to Pusser's which claims to have introduced Munich to classic American cocktail bar culture when it opened in 1974. Downstairs you'll find gifted pianists tickling the ivories every Thursday to Saturday from 9pm – you'll need a reservation! The best part? These guys are so passionate about cocktails that they trademarked their own PUSSER'S PAINKILLER™. As tasty as it is strong, you might not remember the evening, but you'll have a great time.
Falkenturmstraße 9, 80331 Munich, Germany, +49 89 22 05 00.
See how in sync you are with a night on the dancefloor! In the creative quarter around Ostbahnhof you'll find live-music-lovers' haven, Nachtkantine. Formerly the staff cantine for Pfanni — a major Munich manufacturer of all manner of potato-related product, they now host several dance-themed nights such as salsa and swing with live music to match. Even if you don't want to get up on the dancefloor yourself, watching others Charleston, Lindy Hop, or tango the night away is great entertainment.
Grafinger Str. 6, 81671, Munich, Germany, +49 8944 45 10 84.
If you have more than a couple of days in the city, make like a Münchner and spend the afternoon relaxing together by a lake. Just 36 minutes on the S-Bahn from Marienplatz will take you to Lake Starnberg – Germany's fifth largest freshwater lake! Only 25 km from the centre, it feels like another world. Starnberg even gets a mention in T. S. Elliot's poem, The Waste Land. If you're not inspired to pen a poem, stroll around the lakeside, sunbathe and admire the view.
Bahnhofpl. 5B, 82319 Starnberg, Germany.


When Rachel questions Dean, he reveals his apprehension of her meeting his family. That doesn't faze her and she gives him an invitation for a hometown date. From Week 6 of The Bachelorette 2017. Watch all-new episodes of The Bachelorette MONDAYS 8|7c on ABC.


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Garrison Leykam, PhD, Certified Business and Career Coach
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Bob Dylan on Success
November 22, 2016 garrisonleykamphd	Leave a comment
I grew up learning the guitar and being inspired by American songwriter, singer, artist, and writer Robert Allen Zimmerman, aka, Bob Dylan. Dylan is the reason I played the coffee house circuit during college and found my way into the musical venues of Greenwich Village, such as The Gaslight Café (which on some nights was locked down because a young and reclusive Bob Dylan was in attendance), The Bitter End (where Dylan performed with Patti Smith) and the Village Gate (Dylan wrote "A Hard Rain's A-Gonna Fall" in 1962 in Chip Monck's apartment in the basement of this building).
Dylan has been influential in popular music and culture for more than five decades with his most celebrated works coming out of the 1960s with such social unrest anthems as "Blowin' in the Wind" and "The Times They Are A-Changin.'"
Bob Dylan's musical legacy includes selling more than 100 million records, 11 Grammy Awards, a Golden Globe Award and an Academy Award. He has been inducted into the Rock and Roll Hall of Fame, the Minnesota Music Hall of Fame, the Nashville Songwriters Hall of Fame and the Songwriters Hall of Fame. Dylan was awarded a Pulitzer Prize special citation for his "his profound impact on popular music and American culture, marked by lyrical compositions of extraordinary poetic power." Among his other notable honors are the Presidential Medal of Freedom and the Nobel Prize in Literature.
Dylan's lyrics defined a generation and musically crossed all generations. He speaks to the hearts of everyone who yearns to pursue his or her destiny:
"What's money? A man is a success if he gets up in the morning and goes to bed at night and in between does what he wants to do." —Bob Dylan
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Tag: studio pottery
What is Studio Pottery?
Post date 31st July 2019
It is always hard to say what the joy is in studio pottery, but I think it is knowing that it is crafted and made rather than mass produced in a factory. There has always been a tradition of decorated slipware in pottery as other than paintings, carvings in churches and textile embroidery there were few opportunities to ever see any decoration on items. If you did, it was normally because you too had money.
Thomas Toft – Staffordshire Slipware Dish, c1670-90
After the fashions of early slipware and large decorated chargers came the smaller refined pots that the public would buy in the Victorian periods. This followed the social change of home ownership and so factories had new markets to cater for. This is the time when Royal Doulton and Brannam Pottery both stopped making sewage pipes and chimney pots and started to make domestic kitchenware and vases.
Arthur Bamkin for Charles Brannam – Sgraffito Cup, 1898
After the fashions of early slipware and large decorated chargers came the smaller refined pots that the public would buy in the Victorian periods. This followed the social change of home ownership and so factories had new markets to cater for. This is the time when companies like Royal Doulton and Brannam Pottery both stopped making sewage pipes and chimney pots and started to make domestic kitchenware and vases.
Robert Wallace for Martin Brothers – Double Sided Face Jug, 1901
The Martin Brothers whose large birds command such high prices also demand a mention for they were the blurred line of Doulton's factory made designs and Brannam Pottery's craft. They created vases with bold and bright decoration before going into a series of ceramics with natural earthy tones. The most interesting thing about them is that they can be incredibly surreal, and, well, tacky. Some are beautiful, but I thought it was good to show some early surrealism.
Joseon Dynasty Moon Jar, 18c.
The moon Jar above is the most famous example of Bernard Leach's effect on British Crafts. He bought the jar while out in the East and brought it back to Britain and when he died he left to Lucie Rie, who in-turn left it to the British Museum.
Bernard Leach was raised in the days of the British Empire. His father worked for the Hong Kong and Shanghai Bank and as a child he was based in Hong Kong and in Japan before returning to Britain to attend schooling. He attended the Slade for a time and then the London School of Art in Kensington where he was taught etching by Frank Brangwyn. Leach was at this time very fond of Etching and returned to Japan with the intention of teaching it to the Japanese.
Bernard Leach – A London Scene (Etching), 1908-9. (Leach-Redgrave Restrike)
While in Japan Leach became obsessed by the craft of pottery and took lessons with Urano Shigekichi. After learning the industry for a year he set up his own pottery in Japan before moving to China. He exhibited his works and this lead to the introduction to Shōji Hamada.
Bernard Leach – Leaping Fish Vase, c1965
Hamada was deeply impressed by a Tokyo exhibition of ceramic art by Bernard Leach, who was then staying with Yanagi Sōetsu, and wrote to Leach seeking an introduction. The two found much in common and became good friends, so much so that Hamada asked and was granted permission to accompany Leach to England in 1920 when the latter decided to return and establish a pottery there.
Edgar Skinner – a friend of Leach's father introduced him to the St. Ives Guild of Handicrafts which was supported by local wealthy philanthropist called Francis Horne who lived at Tremorna in Carbis Bay. She offered him a capital loan of £2500 to set up his pottery with Hamada and also an assured income of £250 for 3 years.
The Leach Pottery was founded and over the next ten years they would experiment with the clays, slips and glazes in the UK and different woods to burn in the kilns. In 1923 Michael Cardew joined the pottery and left some years later to found Winchcombe Pottery.
The Leach Pottery took on various students to work there: Katharine Pleydell-Bouverie, Norah Braden, Charlotte Epton and Dorothy Kemp. It was not the only pottery but I think it is honest to say the Leach pottery and the skills learnt in Asia have made him important. His influence would go on when there was a serge in home pottery in the 1960s and people copied his designs and used his glaze recipes.
Charlotte Epton – Jar and Lid, c1930
The other pottery that helped the surge of British Studio Pottery would be at Dartington Hall. Bernard Leach helped set up the pottery in the late 1920s. He recommended Sylvia Fox-Strangeways who was the first potter at Dartington. She was joined by Marianne De Trey who would later run it and education pupils.
Many other potters were forging the way in Studio Pottery in the interwar years: William Staite Murray, Dora Billington, Lucie Rie, Ursula Mommens, Ray Finch and Hans Coper. But to list the styles they made, the shapes of pots and their individual glazes would make this post too long
In the 1960s and 70s in the UK there was a boom in the amount of small potteries. Some looked back at the methods of making pottery in the Leach-Asian tradition, some went on to make domestic wear, others just experimented with styles. There are so many wonderful potters from all over Britain and their decorations and ways of potting are all so different. To collect it now doesn't have to be expensive as some galleries would have you believe and I have been both collecting and selling pots in Cambridge for years.
Peter C Arnold for Alderney Pottery – Pot and Lid, c1970
I don't know if the modern potters would call it their moment of postmodernism, but there are many craftsmen out there who are experimenting with the size and form of things. Below is plate by Dylan Bowen who has an amazing eye for almost careless slip designs.
Dylan Bowen – Plate, c2015
Now some potters make record amounts at auction and museums have exhibitions of their pottery, like Kettle's Yard with Jennifer Lee. In the 1990s David Bowie invested in the Leaping Fish Vase by Bernard Leach and in the sale of his collection of art it broke the record for a Leach work at £32,500.
Tags studio pottery
John Piper Ceramics
Post date 11th April 2016
John Piper, most famous for his stormy skies and paintings of bombed Coventry. Here are some quotes on his designs for pottery:
John Piper — Tate Gallery
Pottery decorated by Piper was first seen publicly in Marlborough Fine Art in 1972, when a considerable number and variety of pieces was included in an exhibition of large paintings and gouaches.
They are a collaboration between decorator and potter, and began when the opportunity arose for Piper to work with Geoffrey Eastop, who made earthenware to his design and taught him the techniques of moulding and glazing.
These decorations were mostly heads or decorative abstract designs, but another large group made in 1982 in association with the Fulham Pottery included landscape variations after old masters, some of them on obelisks and candlesticks, The playful mood of the decorations recalls at times English slipware, Renaissance maiolica Picasso's painted ceramics.
John Piper — Tate Gallery p137
From: John Piper: The Robert and Rena Lewin Gift to the Ashmolean
The opportunity for Piper to decorate ceramics came from his meeting with the potter Geoffrey Eastop, who agreed to set up a pottery next to his house in 1969. Eastop worked independently and with Piper. He had also been a painter, and was interested like Piper in modern French art, though from the point of view of a generation younger, and not for his own ceramics.
Piper designed and decorated plates, jugs, vases and obelisks. The body of the pots was made by assistants, and Eastop always advised and worked with him.
Piper's attitude was that of a painter — impulsive, intolerant of technical limitations and extreme in colour. As with the making of stained glass and screenprints, his designs set a challenge to his collaborator, which he was left free to interpret. John Piper: The Robert and Rena Lewin Gift to the Ashmolean — 1992 — David Fraser Jenkins p20
Tags british art, Ceramics, john piper, John Piper Artist, Romantics, studio pottery


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Next Chapter For Biotech? Many Say 'Convergence' With Data Science
By WMIF Admin | June 13, 2018
by WBUR
June 8, 2018- So far, the digital revolution has mostly been a disappointment in health care. Doctors stare at their screens instead of us. Specialists and emergency rooms still don't have all our records.
But artificial intelligence, big data analytics and deep learning are converging on health care in a big way, information technology experts insist. The changes have already begun. And if and when they really take off, such convergence of biology and technology should bring about a complete transformation of medical care.
"My personal perspective would be in three to five years, the huge majority of patients will be touched one way or [an]other with some AI-related system, whether they know it or not," says Chris Coburn, chief innovation officer at Partners HealthCare, who recently led a three-day conference on the topic of artificial intelligence, or AI. "The scope of the potential benefit is at times not easily even imagined."
Coburn and others cite numerous examples where artificial intelligence is already improving health care:
— Digital visual analysis is beginning to replace pathologists at identifying dangerous tumors.
— Devices are increasingly able to monitor patients at home to catch problems before they become serious.
— Pharmaceutical companies like Amgen and Novartis are using deep learning and artificial intelligence to shorten their drug development process and improve their odds of successfully bringing a drug to market.
— Cellphones and watch-like mobile devices are increasingly being used to monitor healthy people for changes that might indicate impending problems.
— And in hospitals, algorithms can help indicate which patients need immediate attention and which should be left alone to rest.
"Our patient monitoring and guardian algorithms can actually predictively say how a patient is doing," says Frans van Houten, head of Royal Philips, the Dutch conglomerate now focused almost entirely on health care technologies.
Houten, whose company is in the process of consolidating its U.S. research operations in Cambridge, says digital algorithms can predict which patients are vulnerable to life-threatening infections and which to heart attacks.
"And that allows the health system to proactively direct staff to the patients that need [care], versus the patients that don't," he says. "So our technology can play a big role for precision care and raising productivity."
Similarly, Colin Hill runs a Cambridge company, GNS Healthcare, which analyzes vast amounts of patient data to derive information that can improve care.
"We're on a path to turning the lights on and revealing what works for whom," he says. "And by getting at the underlying mechanisms of these diseases, we can now stop the guesswork. That's what's really exciting for me."
His company recently used genetic data from a large number of patients with the blood cancer multiple myeloma to identify patterns in those who were helped by a costly, potentially dangerous bone marrow transplant. If the findings are validated, patients whose genetics suggest they wouldn't benefit could be spared the time, energy, expense and dashed hopes of a fruitless procedure.
Thanks to improvements in artificial intelligence, Hill says, "we're now able to learn that kind of causality — those kinds of cause-effect relationships — straight from real-world data."
"As a society, we are coming to grips with the fact that we have a health care system that costs far too much and delivers far too little…"
Colin Hill, GNS Healthcare
Hopefully, this will also save money, which is driving the current interest, Hill says.
"What's changed is the convergence of both the data and the technology capabilities," he says. "And I think the environment's also changed. As a society, we are coming to grips with the fact that we have a health care system that costs far too much and delivers far too little and it is ultimately not sustainable the way it is."
Nobel Laureate and MIT Institute professor Phil Sharp has an even broader vision of this convergence: It's not just computer science and biology that are converging, but engineering, physics, material science and agriculture too, he says.
"Life science is part of all of those processes and bringing physicists and engineering and information technology together to integrate life science with the translation to solving those problems is what convergence is about," Sharp says. "It'll be decades of exciting science and exciting technology."
'It Doesn't Always Go The Way We Hope'
Despite its potential, some people say that artificial intelligence is the future of health care — and always will be. Skepticism remains high because of problems with the electronic health record, which has taken years longer than expected to become functional and constructive.
"We hope that things are going to go well. But specifically in health care it doesn't always go the way we hope," says Andrew Beam, an instructor and junior faculty member in the department of Biomedical Informatics at Harvard Medical School.
GNS Healthcare's Hill says he finds it annoying when tech people assume it should be easy to bring change to health care.
"When folks come from the tech world thinking that they're going to come and build the iPhone of human disease and health care, one of the reasons why they stumble with it is because the complexity of these systems is just beyond anything we've dealt with," Hill says. "It's a fundamentally different problem."
There is no room for error when someone's health or life is on the line.
And privacy is an even bigger issue in medicine than on social media. No one wants their medical records on display on the internet.
Beam says that although there is more oversight in medicine, privacy breaches will happen.
"I think it's going to continue to be a problem," he says. "The unfortunate fact in cybersecurity is that the bad guys are always just ahead of the good guys and there's sort of an ongoing arms race."
Despite the concerns about digital health, there's clearly a growing interest in the combination of computer technology and medical care.
Abbie Celniker, a partner Third Rock Ventures, says so far, her venture capital firm hasn't invested directly in artificial intelligence or machine learning companies. But that day may not be far off.
"We are starting to really do our homework and think about the most optimal places to bring together therapeutic development and digital health," she says.
Others are investing, too. Last month, pharma giant Roche spent $1.9 billion to buy Flatiron Health, a New York startup that tries to advance cancer care by analyzing huge datasets of patient records.
Celniker says that most of the companies Third Rock has helped start already use digital technologies to analyze datasets, crunch numbers or improve efficiency.
"But applying it in a bigger way, bringing together more diverse datasets, and having things learned from those very diverse datasets, that's something that we're just trying now to figure out where's the best place to investigate," she says.
Greater Boston has all the necessary ingredients to lead in the area of digital health, a number of local experts say, continuing to keep the so-called BioBoom alive for years to come.
"Digital health is what's next. Precision medicine, personalized medicine — that is what's next," says Bob Coughlin, president and CEO of the nonprofit Massachusetts Biotechnology Council. "Now let's ask, where is most of that research in those areas — in digital health and precision medicine? What in gene therapy and immunotherapy and gene modification and exon skipping and CAR-T therapy, CRISPR technology — where's most of that happening? Well, folks, you can walk to it right here."
Although digital giants like Microsoft and Google are headquartered in Silicon Valley, they now have outposts in Cambridge. They're the ones driving up the rent in Kendall Square, Coughlin says.
And there's a broad range of expertise here, which will be essential for this convergence, Harvard Med's Beam says.
"You can't just be a computer scientist working in isolation on artificial intelligence if you want to change biology and medicine," he says. You have to partner with doctors, engineers and hospital staff. "And no matter what area of biology or medicine would like you to use AI to improve, there is a world expert in that area here Boston."
http://www.wbur.org/commonhealth/2018/06/08/biotech-artificial-intelligence-convergence
Posted in News and tagged AI, Chris Coburn, Data Science, Partners HealthCare, Philips, World Medical Innovation Forum


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WHY GEORGE FLOYD'S DEATH MUST ADVOCATE GLOBAL SOLIDARITY FOR HUMAN RIGHTS – ANYTHING LESS IS A GROSS INJUSTICE IN COMBATTING GLOBAL US IMPERIALISM, WHITE SUPREMACY AND ISRAEL'S COLONIAL DOMINATION
by Ziyaad Ebrahim Patel | Jul 8, 2020 | Breaking News, World News |
By Ziyaad Ebrahim Patel
Above Photo – An Israeli soldier presses his knee into the neck of Palestinian youth in the West bank city of al-Khalil (Hebron) on May 11, 2012, Occupiedpalestine.wordpress.com
The untimely death of George Floyd has sparked outrage, but also anti-racism campaigns across the United States and the world.
Rights groups are vehement, racial discrimination is deeply entrenched in American society. Racism against black Americans is rife despite every US citizen, black or white expected to be accorded equality of civil and political rights
It becomes incumbent to investigate whether the current US political establishment perpetuates white racial supremacy and discrimination or diffuses racial tension by advancing life, equality and human dignity to all its citizens.
Trump's predecessor was the first black president which appeared on the edifice, America had finally evolved from its racial enclave. But the parochial proverb, "never judge a book by its cover' could not hold truer in underscoring the darker shade of skin colour would respect human rights, including the right to life, dignity and equality.
It is unfortunate that US foreign policy under Obama's administration was fraught with a dismal global human rights track record.
US military forces have been at war for all eight years of Obama's tenure, the first two-term president with that distinction of airstrikes or military raids in at least seven countries: Afghanistan, Iraq, Syria, Libya, Yemen, Somalia and Pakistan.
Photo – Former US President Barack Obama
THE CASSIUS CLAY TRANSFORMATION
A comparison of influential black leaders on human rights and international solidarity, I am drawn to the US civil rights movement in the 1960's. Muhammad Ali was voted the greatest athlete of the 20th century by Sports Illustrated. This rights advocate was stripped off his championship titles and at the prime of his career was banned in participating from heavyweight boxing.
Why? He undertook a just religious and moral position at a time of heightened black consciousness where white superiority complexes and racism tore through the United States. This infringed on his own human dignity and equality rights, whilst in the same vein he was conscripted to serve in the US army to fight an unjust and immoral war.
He aptly argued it was his government that acted immorally, and he did not personally have any dispute with the Viet Kong.
Photo – Muhammad Ali, Sports in Black and White, A study of civil rights movement through sports
DEMOGRAPHICS OF BLACK US SERVICEMAN
In 2019, Pew Research Center disclosed 2017 racial and ethnic profiling – 57% of US service members were white, 16% black and 16% Hispanic. Some 4% of all active duty personnel were Asian and an additional 6% identified as "other" or unknown.
The Iraq war, black serviceman constituted an average of at least 15% combat troops in-country at any given time and in the earliest weeks of the conflict accounted for a startlingly high percentage of casualties.
Black US servicemen have been actively deployed to regions like Afghanistan and Iraq in sustaining US imperial hegemony. These unsanctioned wars have incontrovertibly inflicted severe harm and displaced millions posing a direct danger to world peace, safety and security.
Should these servicemen implicated in the gravest perpetration of injustices against humanity, war crimes and disproportional use of force be preferentially treated on the premise that a black life holds more weight than an innocent human life? Of course not.
Photo – Reuters US Iraq War Timeline, The Telegraph
ANTI-RACISM FIRST AND FOREMOST IS A HUMAN STRUGGLE FOR OUR COMMON HUMANITY
We must remain conscious in our advocacy tools by not inadvertently excluding global solidarity to localised struggles which may perpetuate the colonial psyche of white domination. More so, can we ever expect of white neo conservative supremacists deeply rooted in racism to acknowledge black lives matter without further humiliation to black people?
The South African anti-apartheid struggle was able to successfully bridge that gap in bringing black African equality rights to the fore. Anti-racism constitutes first and foremost a human struggle of our common humanity that must be protected by law. So too, should other struggles by emphasising that being human comes first before colour, creed or religion.
The analogy may be applied in how successive US administrations have cast peace loving Muslims as terrorists. Whilst the war on terror conceived Islamophobia, the struggle continues in changing Islamophobic attitudes that tramp equality and dignity rights of Muslims.
Do all Muslims lives matter? The answer lies in human rights which must be applied equally to any religious affiliation which may justly and constitutionally be limited by the rule of law, where religious fanaticism antithetic to any religious beliefs poses or causes severe harm or danger upon the life and dignity of other innocent human beings.
FLOYD'S MURDER IS A MICROCOSM OF THE EFFECTS OF US IMPERIALISM
Successive US administrations have unashamedly iterated that its economic and regional interests will always trump fundamental human rights violations and war crimes, be they in the middle east states Iraq and Syria or Afghanistan, Pakistan and Libya. Notwithstanding, the US long and brutal history of covert operations in Latin America and recent political meddling in sovereign states like Venezuela.
Saudi Arabia and Israel routinely violate, torture and maim its own citizens or those protected under international humanitarian law and the Geneva conventions with full support and enjoyment of US bilateral ties. Acts of resupplying these regimes with military munitions in crimes perpetrated against the Yemenis and Palestinians are wholly unconscionable deeds.
Floyd's murder is a microcosm of the millions of dead and displaced in the Middle East. The physical defects of children born in Iraq, from the effects of depleted uranium belies a nefarious system which has for decades advanced imperial hegemony, despite the skin tone colour of its Commander in Chief or its US serviceman.
One must probe into the agenda of security collaboration between abusive agencies where aggressive law enforcement, manhandling of Palestinians languishing in Israeli prisons and detention centres in the OPT' s or slaying of the innocent and vulnerable, like Eyad Al Hallaq remains a daily occurrence in Palestinian lives.
The importation onto American shores and into the Minneapolis Police law enforcement agency with the deadly knee on neck restraint, "I can't breathe!" must beckon the plight of the oppressed.
Photo – Israel Palestine News, Israeli police officers detain a Palestinian protestor on March 12, 2019
PEACE IN THE 21st CENTURY
We must strive for a safe future world for all who live in it, where life, dignity and equality rights are mutually respected. This requires assiduous implementation within a constitutionally informed universal human rights framework.
With zero tolerance on racial discrimination, law enforcement and institutionalised commissions and equality courts in adherence to a human rights culture, may be the beginning in altering racist colonial divides of the "us" and "them" mentality.
Towards a common citizenry of life, equality, human dignity and opportunity must be the mantra.
Equally so, should be strong advocacy by Rights Groups for transformation of US Foreign Policy ushering in an era of accountability for war crimes perpetrated under imperial agendas seeking justice for the innocent violated with impunity. The US must submit its state leaders and military commanders to the jurisdiction of the International Criminal Court for war crimes investigation.
The calling for reform whilst not abusing veto rights in safeguarding universal human rights rather than protecting regional interests at the UN Security Council will perhaps advance and restore the purpose of the United Nations formation.
ANTI APARTHEID STRUGGLE
For universality of human rights causes, I draw on my own country which bore the brunt of white supremacy, apartheid, and colonisation. The anti-apartheid struggle was hard fought on commonality principles that out of apartheid would emerge a multiracial, free and democratic society ascribed in the freedom charter for all who live in it. This was ratified in the South African constitution, considered to be the most advanced entrenchment and justiciable bill of rights. These inalienable rights include both civil and political rights with non-discrimination on race, colour, creed, or religion.
The anti-apartheid struggle succeeded for a multitude of reasons, economic sanctions, boycotts, divestment, global solidarity, grass root resistance, UN resolutions and conventions on suppression of apartheid and state enforcement.
Indeed, the wisdom of creating a multiracial society where human rights applied displaced counterproductive ideals. Nelson Mandela at the infamous Rivonia treason trial declared from the dock, "During my lifetime I have dedicated myself to this struggle of the African people. I have fought against white domination, and I have fought against black domination. I have cherished the ideal of a democratic and free society in which all persons live together in harmony and with equal opportunities. It is an ideal which I hope to live for and to achieve. But if needs be, it is an ideal for which I am prepared to die."
The future demands that we breakout out of historical colonial shackles of race and class divides, which imprison minds. Our different shades must enrich our common humanity as South Africans embraced a rainbow nation. Mandela's profound words at the cusp of his freedom, "As I walked out the door toward the gate that would lead to my freedom, I knew if I didn't leave my bitterness and hatred behind , I'd still be in prison".
We must advance out of the COVID-19 pandemic, climate change, wars and regional conflict to realise an economically equitable and environmentally sustainable world free of militarism, occupation and prejudice.
Finally, Oliver Tambo's prophetic words are relevant today as when it was first said, "What we want in South Africa is our humanity to be acknowledged".
This should equally apply to the world we live in today in growing inclusive societies with the uprighteous morality of Muhammad Ali and his generation in upholding human rights.
Ziyaad Ebrahim Patel
Practising Attorney in Johannesburg. Partner at the firm Ziyaad E Patel Attorneys. International Human Rights and LAWFARE ACTIVIST.
Latest posts by Ziyaad Ebrahim Patel (see all)
TALIBAN VICTORY OVER THE US RECLAIMS AN IMPORTANT PROTECTION UNDER INTERNATIONAL LAW – RIGHT OF SELF DETERMINATION - August 24, 2021
Reflections on South Africa's Insurrection – 27 years post apartheid - July 19, 2021
THE CORONAVIRUS PANDEMIC SPOTLIGHTS ISRAEL'S GENOCIDEPRISON STUDIES REPORT – CAN LAWFARE HOLD ISRAEL ACCOUNTABLE? - April 9, 2021
Author: Ziyaad Ebrahim Patel


Couldn't pass up a question from a fellow MA Dad.
It looks like you are the beneficiary of good timing for this upcoming trip. As you probably already know, Massachusetts' February school vacation week is from 2/21 through 2/25 (not including the weekends), so you will have already boarded your plane for home before the hordes come South. Additionally, a good part of the country does not have school breaks in Feb. AND April, but sometimes only March. Again, you win!!
I have been to Walt Disney World in early February and the crowds are typically some of the smallest of the year. This is more than likely still true. Noticing the rate differences like you did should also be a good indicator that crowds will pick up AFTER your departure.


In the recent times, the educational market has advanced significantly, where technological platforms and hybrid teaching support with flexible study mode has become the key to success. Regional Access Points are built around the concept of blended learning, a structured study option that uses a combination of support elements from the academic team of School of Business London and its partners. School of Business London has built Regional Access Points (RAP) network globally which removes boundaries to the education and enables us to provide our qualifications across the world. We are an IT-driven education establishment, and we rely on a comprehensive quality control process which is managed by our qualified and experienced academic and admin team at SBL.
Regional Access Points (RAP) are authorised to promote and recruit learners for the courses delivered by School of Business London except for CMI courses. Regional Access Points are not authorised to promote CMI programs offered by School of Business London. RAP act as a representative of SBL for initial face-to-face contact and document collection from prospective students, and to provide all required information to all potential students, staff members and other stakeholders accurately and transparently. Every Reginal Access Points (RAP) goes through a rigorous quality check and undergoes a probation period of six months.
Tamkeen Education is the trading name of Tamkeen Consultancy Centre, specialising in education and training consultancy. Tamkeen Education is the exclusive Regional Access Point in the UAE, located in Sharjah. Being the regional centre of School of Business London (SBL), Tamkeen Education recruits students to SBL for various accredited business, marketing, accounting & IT qualifications at an affordable cost. In addition, they also recruit students to other universities in different countries for many distance and online learning programs. Besides for those who are looking to study overseas, Tamkeen Education provides comprehensive service that guides students every step of the way, no matter what level of education they are seeking.
International Institute of Management and Technology Studies (IIMTS), a division of Genius Group Global is our Regional Access Point (RAP) in Oman and Qatar. IIMTS is committed to offering them a wide array of academic programs consistent with a rigorous approach to higher education. In Qatar, they are based at 1st floor, 3rd Block, Ali Bin Jabor and Sons Complex, Near Gulf Cinema Signal, Doha, Qatar.
International Institute of Management and Technology Studies (IIMTS), a division of Genius Group Global is our Regional Access Point (RAP) in Oman and Qatar.IIMTS is committed to offering them a wide array of academic programs consistent with a rigorous approach to higher education.In Oman, they are located at 2nd Floor, Al Sourah Building, Azaiba Oman.
International Institute of Management and Technology Studies (IIMTS), a division of Genius Group Global is our Regional Access Point (RAP) in Oman, Qatar and India. IIMTS is committed to offering them a wide array of academic programs consistent with a rigorous approach to higher education. In India, they are located at 3rd Floor, Majestic Complex, Malaparambu, Kozhikode.
Global Merit Management Ltd is our RAP in Hong Kong, located at Silvercorp International Tower, 707-713 Nathan Road, Mong Kok, Kowloon, Hong Kong. Global Merit Management Ltd was established in 2008 in Hong Kong with a presence in a few Asian cities to serve the educational institutions and the public in the fields of international program consulting, institutional development, training & development, project management and investment analysis & market research. By offering online and traditional classroom-based educational services, workshops, and seminars, GMM places quality continuing professional education within the financial and physical reach of millions of individuals.
Infoera Academy is a RAP of SBL in Malaysia. Infoera was established in 2001 to provide continuing education for working adults. It has since grown from only five students back in 2002 to an active student body of more than 500 students' population now in the head office at Penang, Malaysia. To date, Infoera Academy has trained more than 3,000 students from different background at different levels, and they are now serving in various capacities both locally and globally. They are located at 26 Jalan Prai Jaya, Penang, 13700, Malaysia.


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How old was Sally Field in the movie The Little Mermaid: Ariel's Beginning?
Sally Field was 60 in The Little Mermaid: Ariel's Beginning when she played the character 'Marina Del Ray (voice)'.
That was over 14 years ago in 2008.
Today she is 76, and has starred in 64 movies in total, 11 of those since The Little Mermaid: Ariel's Beginning was released.
How old do you think she looks in the movie?
In The Little Mermaid: Ariel's Beginning, I think Sally Field looks:
👵 Older than 60
👩 About 60
👧 Younger than 60
🍿 Just show results
Director Peggy Holmes has worked with Sally Field just once in her career.
Sally Field's first movie was as 'Mercy McBee' in The Way West, released in 1967 when she was 19
The Little Mermaid: Ariel's Beginning scores 6.73 out of 10 on TMDB.
(Continued after the ads)
The cast of The Little Mermaid: Ariel's Beginning
Samuel E. Wright
Sally Field's other movies
Homeward Bound: The Incredible Journey
Little Evil
Hello, My Name Is Doris
The Way West
1. Christian Bale / American Psycho
2. Margot Robbie / The Wolf of Wall Street
3. Jenna Ortega / X
4. Miley Cyrus / Hannah Montana: The Movie
5. Ann-Margret / Grumpy Old Men
6. Brad Pitt / Troy
7. Al Pacino / The Godfather
8. Thomas Brodie-Sangster / Maze Runner: The Scorch Trials
9. Shia LaBeouf / Transformers
10. Aaron Taylor-Johnson / Kick-Ass
11. Emma Watson / Harry Potter and the Order of the Phoenix
12. Emma Watson / Harry Potter and the Half-Blood Prince
13. Paul Walker / The Fast and the Furious
14. Arnold Schwarzenegger / Terminator 2: Judgment Day
15. Sally Field / Smokey and the Bandit


J Synchrotron Radiat. 2012 May;19(Pt 3):462-7. doi: 10.1107/S0909049512009776. Epub 2012 Apr 6.
Stokes-Rees I1, Levesque I, Murphy FV 4th, Yang W, Deacon A, Sliz P.
Early stage experimental data in structural biology is generally unmaintained and inaccessible to the public. It is increasingly believed that this data, which forms the basis for each macromolecular structure discovered by this field, must be archived and, in due course, published. Furthermore, the widespread use of shared scientific facilities such as synchrotron beamlines complicates the issue of data storage, access and movement, as does the increase of remote users. This work describes a prototype system that adapts existing federated cyberinfrastructure technology and techniques to significantly improve the operational environment for users and administrators of synchrotron data collection facilities used in structural biology. This is achieved through software from the Virtual Data Toolkit and Globus, bringing together federated users and facilities from the Stanford Synchrotron Radiation Lightsource, the Advanced Photon Source, the Open Science Grid, the SBGrid Consortium and Harvard Medical School. The performance and experience with the prototype provide a model for data management at shared scientific facilities.
Geographic distribution of five endpoints participating in the trial of the prototype system. The flags represent, from left to right, Stanford Synchrotron Radiation Lightsource (blue, Stanford Linear Accelerator Center, Palo Alto, CA, USA), Fermi National Accelerator Laboratory (white, Batavia, IL, USA), Northeast Collaborative Access Team (green, Advanced Photon Source, Argonne, IL, USA), National Center for Supercomputing Applications (red, University of Illinois Urbana-Champaign, Champaign, IL, USA) and Harvard Medical School (yellow, Boston, MA, USA).
J Synchrotron Radiat. 2012 May 1;19(Pt 3):462-467.
Example usage scenario. User 'Scott' from the Sliz Laboratory at Harvard collects data at the NE-CAT beamline. It is stored temporarily to a tier 1 staging server in sliz@necat.aps.argonne.gov:/stage/sliz before being archived to tier 2 storage in sliz@necat.aps.argonne.gov:/data/sliz. Scott can use Globus Online to access his data at NE-CAT and transfer it to his personal space on the laboratory file server scott@sliz.harvard.edu:/home/scott or to his own laptop. Other laboratory members can access his data at NE-CAT owing to the mapping of all Sliz Laboratory members to the same system identity. The general public can access public archived data from 2009 in the tier 3 archival storage through a web interface. More recent archived data from 2010 and 2011 is embargoed and not available to the public.


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Shahid Kapoor: "I Think My Kind of Girl Doesn't Exist"
Rashmi Daryanani , 27 Feb 2012
Shahid Kapoor and Priyanka Chopra in Teri Meri Kahani
Just back from his four-day birthday bash in Goa, Shahid Kapoor made a comment stating, that he's beginning to think his kind of girl doesn't exist, and that marriage is definitely not on his mind, as of now.
He also noted, that while most people think actors generally fall for others within the profession, he is more than happy to meet girls outside of the industry. But as of now, he's not even thinking of marriage, and believes it will happen when it has to happen. So this guy is definitely giving 100% to his career right now and has put his personal life on the backseat; he's looking forward to his Kunal Kohli film (tentatively titled Teri Meri Kahani), with Priyanka Chopra, which is all set to release in June of this year.
As for his comment on how he thinks his kind of girl doesn't exist, I only have one thing to say…
Rashmi Daryanani and Shahid Kapoor
Main hoon na!!! :)
#Kunal Kohli#Priyanka Chopra#Shahid Kapoor#Teri Meri Kahani
Fan-made Family Picture Of Shah Rukh Khan With His Late Parents Goes Viral Online
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New Song Alert: Varun Dhawan & Sara Ali Khan's 'Mirchi Lagi Toh' Is Out Now


Easy ways you can stay fit even in lazy winter!
Weight Loss Story: How I reduced weight from 85 kgs to 63 kgs!
These 3 winter salads can make you lose weight in 3 weeks!
Weight Loss Story: I lost 39 kilos by this self-made diet plan in just 6.5 months!
What is the toughest part of being overweight? Some say being unhealthy and giving an open invitation to diseases. Some say that it makes them poor role models for their children. However, what most say is that the toughest part is when others body-shame you. Being made fun of can be a really demotivating factor for those struggling with weight issues. A similar pull-down was felt by Chirag, a 22-year old, who felt that everyone disapproved of his looks. Many are bogged down by such pressure, though some, like Chirag, decide to fight back. It was in January 2017 that his fitness journey began. It wasn't easy initially but his determination and patience helped him achieve his goal and in less than a year, he is at an ideal weight. Here's his journey from fat to fit.
That time when no one stood with me and everyone used to call me ugly and fat. My face was very chubby and people made fun of it. So, one fine day I finally decided to prove everyone wrong and it was in January 2017 when I started my weight loss journey.
Fitness secrets I unveiled: There are no secrets to gaining fitness. A healthy diet along with a good workout is all what you need. Also, being determined and consistent towards your goal is as important as your diet and workout.
How do I stay motivated? My motivation is my inner self. As I see my body changing, I become more determined towards my goals. I also follow many athletes and fitness models on Instagram for motivation.
How do you ensure you don't lose focus? As we all know that right focus is everything and so, my focus is on a healthy diet. I make sure that I have 1 cheat meal in a week so that I don't lose my focus. However, I also make sure that I don't overdo it because if I do, I feel guilty later.
What's the most difficult part of being overweight? The most difficult part of being overweight is people making fun of you. Also, all good clothes do not come in large sizes.
What shape do you see yourself 10 years down the line? 10 years down the line, I hope to see myself as a fitness model with a perfect physique.
What are the lifestyle changes you made? The most important change that I made in my lifestyle is shifting from eating junk to a healthy diet. Earlier, my evening meal used to be a burger with french fries and a fizzy drink every day but now I rarely eat burgers.
What was the lowest point for you? The lowest point for me was in the initial stage when I was not able to lose weight as I didn't have much knowledge about workout and diet. But then, some books and internet helped me.
Lessons learnt from weight loss: The lesson that I have learnt from weight loss is that a healthy body is everything. This is what we can achieve only with healthy diet and proper workout. Also, a healthy body leads to positive and healthy mind. This journey has been the most memorable journey of my life.


Last year, the iconic video game character Lara Croft returned to the big screen with the Tomb Raider reboot, starring Alicia Vikander as this new iteration. Although that film didn't exactly usher in the long hoped-for, perpetually delayed golden age of video game movies, it looks like this new Lara Croft will get another opportunity to make that happen. That's because Tomb Raider 2 just took a major step forward by hiring a writer.
Writers Geneva Robertson-Dworet and Alastair Siddons handled the script duties for Tomb Raider, but MGM and Warner Bros. have brought in some new talent, hiring Amy Jump to pen the sequel, according to Deadline. Most of Amy Jump's big screen work has come in collaboration with director and her partner, Ben Wheatley. Together they co-wrote 2016's Free Fire and the upcoming Freak Shift. Amy Jump also wrote the screenplays for Wheatley's High-Rise and A Field in England.
Amy Jump has experience writing action in Free Fire and apparently Tomb Raider star and Oscar-winner Alicia Vikander liked what the writer brought to the table for Tomb Raider 2. We don't yet know what the story will be for Tomb Raider 2, but the first film ended on something of a cliffhanger, so I would expect Lara Croft to go on another globe-trotting, tomb-raiding adventure where she continues to fight the shadowy Trinity organization that has infiltrated Croft Holdings.
It is still early, and in addition to the story, we don't know who the cast will consist of beyond Alicia Vikander or who will direct the sequel, be it Tomb Raider director Roar Uthaug or someone new. Nevertheless, this is a major step and indicates that Tomb Raider 2 is moving towards becoming a reality, and that Vikander's Lara Croft will get at least two films just like her predecessor Angelina Jolie, who first brought the heroine to life on the big screen.
This news may come as a bit of a surprise to some considering that Tomb Raider didn't exactly blow the doors off the box office. Domestically, the film never hit number 1 and ended its run with less than $60 million. Lara Croft had much better luck finding treasure overseas though and Tomb Raider finished with a worldwide total of $274.6 million. That's nearly triple its $94 million production budget.
With this news, it is clear that MGM and WB see value in keeping this rebooted Tomb Raider going with the hopes that it develops into a successful franchise, and it has the potential to do just that. The first film seemed to have a lot going for it going in, but ultimately didn't click together for a lot of people and critics. Tomb Raider has a 52% Rotten Tomatoes score, and yet, given the competition, some would still argue that it was the best video game movie to date.
Hopefully the sequel can capitalize on the elements that worked in the first movie while shoring up those that didn't. Alicia Vikander is incredibly talented and her lead performance was one of the highlights of the movie, so a sequel with her in it immediately has serious potential. That it seems that she approved of Amy Jump writing the sequel is also encouraging. Maybe we can even get an Angelina Jolie cameo this time around.
Tomb Raider 2 does not yet have a release date, but we will keep you updated as this sequel moves forward. In the meantime check out our 2019 Release Schedule to see all the movies headed your way this year.


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Kareem Abdul-Jabbar Introduces Himself As Michael Jordan Because Trump Couldn't Tell The Difference Anyway
07/28/2016 09:40 pm ET Updated Jul 28, 2016
By Mollie Reilly
NBA legend Kareem Abdul-Jabbar delivered one of the Democratic National Convention's best jabs at Donald Trump, succinctly skewering the GOP nominee's bigotry with a joke invoking another famous basketball player.
Abdul-Jabbar made a brief appearance at the convention Thursday evening to introduce the father of U.S. Army Capt. Humayun Khan, one of 14 American Muslims who has died serving in the military since 9/11.
"I'm Michael Jordan, and I'm here with Hillary," said Abdul-Jabbar. "I said that because I know that Donald Trump couldn't tell the difference."
Abdul-Jabbar, who was named U.S. cultural ambassador by then-Secretary of State Hillary Clinton in 2012, detailed how Khan's story stands in direct contrast to Trump's xenophobic rhetoric.
"At its core, discrimination is a result of fear," he said. "Those who think Americans scare easily enough to abandon the country's ideals in exchange for a false sense of security underestimate our resolve. To them, we say only this: Not here, not ever."
Watch the clip above.
Editor's note: Donald Trump regularly incites political violence and is a serial liar, rampant xenophobe, racist, misogynist and birther who has repeatedly pledged to ban all Muslims ― 1.6 billion members of an entire religion ― from entering the U.S.
Best Photos From The Democratic National Convention
Mollie Reilly
Assignment Editor, HuffPost
Donald Trump Elections 2016 Democratic National Convention Kareem Abdul Jabbar
Sen. Bernie Sanders (I-VT) delivers remarks on the first day of the Democratic National Convention at the Wells Fargo Center, July 25, 2016 in Philadelphia, Pennsylvania.
Chip Somodevilla via Getty Images


Rose gold has never looked so good. Three sophisticated choices that blend timeless appeal and G-Shock's durability within G-Shock's X-Large analog/digital case designs. Rose gold accents that look great in combination with either black or white. Matte white resin band digital watch with a rose gold/black face.


As IT people, we know firsthand how critical technology is to managing virtual teams. And in today's workforce, virtual teams and contractors are a norm. But here's the rub: We often forget one of our invisible tools -- communication.
When you and your team don't share the same physical space, you need to be even more effective at communicating. Having run my company virtually for several years, I have learned several key things that can be applied to any project.
1. Build trust in person and grow that trust with clear expectations. In order for people to work effectively virtually, there has to be trust. Trust doesn't happen magically. It is built when you bring your team together for training or team building, and then continues to grow with clear expectations consistently set by leaders and met by the team. It's important to bring people together at least once a year. During in-person meetings, I often get a handle on something that wasn't obvious before, and then when we're virtual again, I have invaluable insight that wouldn't have been possible without the time we spent together.
2. Manage results, not activity. In the physical office environment, "busy work" often gets mistaken for real work. In the virtual environment, when you can't see what people are doing, the key is to manage results. Set expectations and monitor the results, not the daily activities. This is empowering for people who are motivated and who take the initiative, and on the other hand it is a virtual microscope, which reveals people who don't know how to get things done. You can usually spot a poor hire in a couple of months and save yourself and the individual a lot of time and heartache.
3. Schedule regular communication. It's important that there is a regular time for reporting both progress and potential pitfalls to the team. This keeps people on track and gives everyone the discipline of a team check-in. It's amazing how much can be accomplished in a 30-minute conference call when you set expectations beforehand and tell everyone what you need to accomplish in that time frame.
Survive the quick read by putting what you need in the lead. I don't have time to read a long rambling piece of prose about anything. Remember that I'm glancing quickly to know what is important and what you need from me. Put that in the subject line and immediately tell me what you need at the top of the e-mail.
Don't cc: the whole world. Don't create work for your colleagues if they don't need to be cc'd. Copy only those who need to know, and let the rest of us receive one less e-mail.
Don't use e-mail to blow a fuse. When you're angry, step away from the keyboard. Nothing is more disruptive or upsetting to anyone's day then getting negative garbage and anger in their e-mail box. Cool off and then send a sane response.
Don't forget that old-fashioned device called a phone. I love it when people say to me: "She didn't respond to my e-mail." And then I inevitably ask: "Did you call her?" And I get this funny look while the person goes back in the memory bank and remembers the good ole phone. It still works wonders, especially if an e-mail chain is getting confusing and/or wasting people's time. Pick up the phone when the e-mail isn't saving time.
5. Create standards that build a cohesive culture. What are your standards of quality? How do you define excellence? What do you expect from the people on your team? Making sure everyone knows the answers to those three questions is especially important when people are scattered geographically. Virtually, you need to create cohesion with excellence and a sense of pride in what your company stands for. People want a reason to belong, and a strong culture gives them a sense of belonging and also the confidence of knowing what the rules of the road are for them and the company.
6. Establish rules of responsiveness. When people are working remotely, it's important that you define what your rules of responsiveness are for your culture. How quickly are people expected to return an e-mail, an IM or a phone call? What is your protocol when people are out of the office or on vacation? If you're in a customer service environment, it's important to have clear expectations regarding how to respond to all customer inquiries. No one likes to be kept waiting, and knowing what to expect immediately lowers the blood pressures on both sides of the customer/company relationship.
Once you have your communication keys in place, you need to model the behavior you want to cultivate. Set some boundaries for yourself, and let your team know when you're not available. If you're on a family vacation, give people plenty of notice, and let them know the time period when you are not available. Empower people when you are unavailable. You'll be surprised at the solutions that magically appear when you are unplugged from your Blackberry. Revel in it.
Michelle LaBrosse, PMP, is the founder and CEO of Cheetah Learning and author of the books Cheetah Negotiations and Cheetah Project Management.


…And with good reason! Protein is key for our hair, skin, nails, immune system, healthy mucosal cells that line the digestive tract… and pretty much every other cell in our body. Protein is so key because it's the backbone, the building block, to cell growth and repair- for every single cell in our body. The good news is that when we eat in a well-balanced way, reaching our protein needs really isn't so difficult… and especially when we're conscious of getting enough- we usually find ways to sneak in some extra protein grams. Like for example in the form of protein powder.
I hear from clients and people I meet all the time that they have a "new" and "exciting" protein powder that they love, and "oh my gosh it's the best" etc etc etc…. but wait, not so fast; because do you know what's REALLY in your protein powder?
Here's the issue. That protein powder you've been using maybe hiding some not so good-for-you ingredients that may be negatively affecting your health. Some protein powders contain heavy metals and other gross things (like DIRT), in addition to refined or artificial sugars, fibers and other things that may be making you bloated and gassy, and may not be helping with your weight loss either.
So, to avoid the dirt, and the grime in your protein powders, it's key to choose ones that are well-sourced and that works for your body. I'm not saying that this list will do the trick, but here's a list of protein powders that I like.So as a way to get you started on your journey toward healthy protein powders, here's our hit list.
Why we love it: Garden of Life Raw Organic Protein is a certified organic, non-GMO, and vegan. It's made with 13 raw sprouted proteins, and has 22 grams of protein. This powder is great for people who are dairy free, and still want a complete profile of all the essential amino acids.
Why we love it: Vital Proteins Collagen Peptides are sourced from grass-fed, pasture-raised cow. Collagen is a protein made up of amino-acids which help our body's connective tissue, skin, hair, nails, as well as gut health.
Why we love it: Tera's Whey is certified organic whey protein is that is locally sourced from pasture-raised cows that eat only organic, non-GMO grass and forage. These cows are ethically-raised and never treated with growth hormones or antibiotics. Each serving has 21 grams of protein.
Why we love it:Organic Bone Broth Protein supplies 20 grams of whole complete protein with 0 grams of sugar. It is great for people with sensitivities to dairy, grains, gluten, peas, soy and nuts. Bone Broth is a nutrient dense stock that provides protein and Type II collagen.
Why we love it:Pea protein powder is made by extracting the soluble pea protein from yellow-split peas. Yellow pea protein is an excellent source of dietary protein for vegans. Naked Pea is made from non-GMO peas that are only grown in North America.
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text:
Knife Skills Are Bulls*it
Same goes for tossing things about in a skillet
91 Comment43 Share
Photo: Claudia Totir/Getty Images
Let me say this clearly: For most of us, knife skills are bullshit.
Knife skills are important to chefs. So are butchering, filleting, and ability to stand for eight hours at a time; the need to work quickly on several levels at once; a willingness to ignore burns and other injuries when necessary; a seemingly supernatural level of judgment of doneness — forget touching: a good chef can tell when something's done with sight and smell — and more.
I would never say that it's undesirable for a home cook to learn those kinds of skills: Judging doneness and understanding seasoning are both way more important than pretty dicing — but I will say it's unnecessary. And emphasizing their importance to home cooks, especially the importance of knife skills — or of tossing things about impressively in a skillet — makes it more difficult to learn how to cook.
There's nothing wrong with real efficiency, of course, but if a lack of elite ability discourages people from attacking a stir-fry, that's ass-backward. I blame cooking shows, which encourage the notion that if you can't dazzle with your knife and skillet you're somehow not a good cook.
Nothing could be more ridiculous. Most good cooking is extremely simple, and although skills are naturally honed and judgment organically improves over the years, their lack in the early days has little impact on the quality of the food you produce.
Me chopping an onion is not a pretty sight. The crew on The Minimalist set used to try to shoot me doing it — "Teach people how it's done" — but I demurred. I've shown people how to chop an onion — how I chop an onion — but it's not how you want to learn to chop an onion. And yet I get by.
I know how you're supposed to chop an onion, but since no one ever threw a 25-pound box of onions at me and said, "Chop this, I need it fast," I never had to rush. Consequently, it takes me maybe 45 seconds, even a minute, to do one, and as I said it's not pretty: A good chef can do it in 10 seconds, and it's a thing of beauty.
Even Nigella Lawson has admitted to having no knife skills. When I talked to her for the podcast, she told me when she's chopping for her TV show, "my director more or less has to put a hand over his eyes as he's checking the monitor. Because he can't bear it when he sees that ... when I've got the camera just on my hands, it makes me so panicked that I can barely hold a knife, let alone chop… But it's good for people to see bad chopping."
You chop an onion in any way that makes you comfortable. If you are the kind of person who takes instructions well, who can follow directions, who's willing to practice new skills (and who's willing to keep their knives sharp, which is important), you can become a first-rate knife-wielder. (You'll still never be as quick as someone who's spent hours and days at repetitive knife tasks, but for that, you should be thankful.) If you're not, join the club.
The vast majority of meals in the world are cooked at home, by women who have no formal training, who do not own $60 knives (let alone that $1500 Japanese model you crave), who may use a sheet of plywood, a scrap of wood, or a rock as a cutting board — or who may use a butter knife or a broken "steak" knife to cut their food while holding it in their hand, who've never been taught how to slice, dice, and mince the "right" way … and who prepare great food two or three times a day. Professionals do things in an educated, scripted way, with reason; amateurs — which may mean "nonprofessional" or "someone who does the work out of love rather than money — do things in other ways, often developed by the rhythms and natural skills that emerge from their own bodies.
Not only is there's nothing wrong with that, at the level most of us cook — once or twice a day, for one or two or four or six people — it doesn't matter at all.
If you want to slice like a pro, get your knives really sharp and keep them that way; then go practice: Watch some videos (not by me!), buy a box of onions, and time yourself; get competitive.
Most people won't bother, and the key is to not let it upset you. As the years go by I find myself caring less and less. Twenty years ago, Daniel Boulud showed me what he called "the peasant cut" which meant cutting your onions, carrots, potatoes, whatever, in more or less random-shaped chunks. (I now realize he was accommodating my lack of skill since we were cooking together, sort of; Jean-Georges Vongerichten once said to me, "That's not dicing; that's hacking." (He was right, of course.) Since then, I do the peasant cut, which means hacking.
If there are a lot of onions to slice or dice or mince, I use the food processor.
My mother's knife skills were learned from my grandmother. My grandmother was a peasant from Poland, who held a potato in her left hand and used a beat-up serrated knife with a wooden handle to cut it using her right. She'd spend 20 minutes cutting up a few potatoes. She was a wonderful judge of doneness: a browning wizard, someone who seasoned with her senses and mostly got it right, despite having limited knowledge of the world's herbs and spices and other — to her — "exotic" ingredients.)
She — my mother — had a little machine called a Chop-O-Matic (I swear), the kind of thing you'd buy in Woolworth's or, later, on television. It was a little round cutting board set in the bottom of a glass cylinder; the mechanism comprised three blades joined in a Y at the end of a spindle, on the top of which was a spring-loaded plunger surrounded by a lid. You put your onion or whatever in there and pounced up and down on the plunger. With a little finagling, you got a perfectly fine dice or mince. I loved that thing.
The food processor killed stuff like that until we realized it was too goddamn big to dice an onion, and so they invented the mini food processor, but then people like Daniel said, "I'm damned if I'm going to plug in an appliance and wash it for one onion."
When Daniel said that, or something like that, when we made this video, I thought, "What the world needs is a Chop-O-Matic, a manual food processor, and I'm going to invent one."
Then it turned out that OXO already did that, so I got one, and it does an amazing job on a couple of onions or carrots, a perfect job on garlic and shallots, and so on. It's not a food processor replacement, but it's a useful knife alternative for those of us with limited skills.
I'm proud to count myself in that group.
91 Comment43 ShareShare
Tossing things about in a skillet is easy and prevents you from scratching your skillets with other utensils, allows you to keep your hands away from the hot fire, and enables you to multi task.
If you ever want to buy a whole chicken and cut it up either before or after cooking it you'd better learn a knife skill beyond cutting an onion in one minute. Nobody says you have to churn out perfect tourne potatoes all day long but knife skills even to the home cook are certainly NOT bullshit
N Allen
Okay. I vehemently disagree. In fact I think this article is probably bulls**t. I'm a chef-educator. Knife skills are hugely important. Once people learn basic, efficient ways to dice and slice they are faster and more confident. Knowing how to cut vegetables in consistent sizes isn't just eye appealing, it also aids in cooking evenly and assists in contributing the right flavor. For instance take garlic: if you leave it whole or crush it you get milder flavor than minced. And if you don't know how to fine mince the garlic your diners end up with chunks of it in their teeth. Yuck. Then there's the size of dice: if you want flavor to mingle, make it small and even. If you want each veg to stand out (or be able to cook longer) use a large dice. I say a lazy cook is the only one who cares not for good knife skills.
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text:
Q: Merge multiple dataframes based on multiple column matching I am aiming to selectively combine several dataframes into a single one in separate steps based on matches in two columns.
Primary Dataset
structure(list(OB_END_TIME = c("2006-01-01 01:00", "2006-01-01 00:00",
"2006-01-01 00:00", "2006-01-01 01:00", "2006-01-01 01:00", "2006-01-01 18:00",
"2006-01-01 01:00", "2006-01-01 00:00", "2006-01-01 00:00", "2006-01-01 00:00"
), Weather.Category = c("Wind", "Flood", "Flood", "Wind", "Wind",
"Wind", "Wind", "Wind", "Adhesion", "Subsidence"), SRC_ID = c(52L,
67L, 103L, 2719L, 105L, 32L, 113L, 6704L, 117L,
9569L), distance = c(4337.916253, 2825.720696, 2825.720696, 2397.887245,
4513.448694, 3787.205117, 3774.967612, 4925.782405, 1178.442845,
1748.086262), PRCP_AMT = c(NA, NA, NA, NA, NA, NA, NA, NA, NA,
NA), MEAN_WIND_DIR = c(NA, NA, NA, NA, NA, NA, NA, NA, NA, NA
), MEAN_WIND_SPEED = c(NA, NA, NA, NA, NA, NA, NA, NA, NA, NA
), MAX_GUST_DIR = c(NA, NA, NA, NA, NA, NA, NA, NA, NA, NA),
    MAX_GUST_SPEED = c(NA, NA, NA, NA, NA, NA, NA, NA, NA, NA
    )), row.names = c(1L, 2L, 3L, 4L, 5L, 10L, 11L, 12L, 13L,
14L), class = "data.frame")

Supporting Dataset 1
structure(list(OB_END_TIME = c("2006-01-01 00:00", "2006-01-01 00:00",
"2006-01-01 00:00", "2006-01-01 00:00", "2006-01-01 00:00", "2006-01-01 00:00",
"2006-01-01 00:00", "2006-01-01 00:00", "2006-01-01 00:00", "2006-01-01 00:00"
), SRC_ID = c(32L, 44L, 52L, 67L, 103L, 79L, 105L,
117L, 113L, 30L), PRCP_AMT = c(0, 0, 0, 0.6, 0, 0, 0.4, 0.2,
0.2, 0.2), HIGH_PRCN_LAT = c(1, 2, 44, 65,
1, 1, 23, 43, 54.1346, 54.04502)), row.names = c(NA, 10L), class = "data.frame")

Supporting Dataset 2
structure(list(OB_END_TIME = c("2006-01-01 00:00", "2006-01-01 00:00",
"2006-01-01 00:00", "2006-01-01 00:00", "2006-01-01 00:00", "2006-01-01 00:00",
"2006-01-01 00:00", "2006-01-01 00:00", "2006-01-01 00:00", "2006-01-01 00:00"
),  SRC_ID = c(105L, 44L, 52L, 30L, 67L, 79L, 103L, 32L, 114L,
    117L), MEAN_WIND_DIR = c(250L, 0L, 0L, 10L, 290L, 290L, 30L,
    0L, 310L, 50L), MEAN_WIND_SPEED = c(3L, 0L, 0L, 10L, 5L,
    8L, 17L, 0L, 1L, 24L), MAX_GUST_DIR = c(270L, 0L, 0L, 30L,
    290L, 290L, 30L, 0L, 320L, 40L), MAX_GUST_SPEED = c(5L, 0L,
    0L, 18L, 11L, 11L, 23L, 0L, 2L, 29L), HIGH_PRCN_LAT = c(1, 2, 44, 65,
1, 1, 23, 43, 54.1346, 54.04502)), row.names = c(6L, 7L, 8L,
10L, 11L, 12L, 16L, 17L, 18L, 19L), class = "data.frame")

r Metadata
platform        x86_64-w64-mingw32
version.string  R version 3.5.3 (2019-03-11)

Prepatory Code
dfX$OB_END_TIME <- format(as.POSIXct(strptime(rain$OB_END_TIME, "%Y-%m-%d %H:%M")), "%Y-%m-%d %H:%M")

All of the dataframes have already had the above code run on their datatime column in order to standardise it for the comparison/matching.
Matching Code
primaryDataFrame <- merge(x = primaryDataFrame, y = supportingDataFrame1, by = c("SRC_ID", "OB_END_TIME"))

Expected Result (Manually generated)
structure(list(OB_END_TIME = c("2006-01-01 01:00", "2006-01-01 00:00",
"2006-01-01 00:00", "2006-01-01 01:00", "2006-01-01 00:00", "2006-01-01 18:00",
"2006-01-01 00:00", "2006-01-01 00:00", "2006-01-01 00:00", "2006-01-01 00:00"
), Weather.Category = c("Wind", "Flood", "Flood", "Wind", "Wind",
"Wind", "Wind", "Wind", "Adhesion", "Subsidence"), SRC_ID = c(67L,
52L, 103L, 2719L, 105L, 32L, 113L, 6704L, 117L, 9569L), distance = c(4337.916253, 2825.720696, 2825.720696, 2397.887245, 4513.448694, 3787.205117, 3774.967612, 4925.782405, 1178.442845, 1748.086262), PRCP_AMT = c(NA, 0, 0, NA, 0.4, NA, 0.2, NA, 0.2, NA), MEAN_WIND_DIR = c(NA, 0L, 30L, NA, 250L, NA, NA, NA, 50L, NA), MEAN_WIND_SPEED = c(NA, 0L, 17L, NA, 3L, NA, NA, NA, 24L, NA), MAX_GUST_DIR = c(NA, 0L, 30L, NA, 270L, NA, NA, NA, 40L, NA),
    MAX_GUST_SPEED = c(NA, 0L, 23L, NA, 5L, NA, NA, NA, 29L, NA
    )), row.names = c(1L, 2L, 3L, 4L, 5L, 10L, 11L, 12L, 13L,
14L), class = "data.frame")

Actual Result (Manually generated)
structure(list(OB_END_TIME = c("2006-01-01 00:00", "2006-01-01 00:00",
"2006-01-01 00:00", "2006-01-01 00:00", "2006-01-01 00:00"),
    Weather.Category = c("Flood", "Flood", "Wind", "Wind", "Adhesion"
    ), SRC_ID = c(52L, 103L, 105L, 113L, 117L), distance = c(2825.720696,
    2825.720696, 4513.448694, 3774.967612, 1178.442845), PRCP_AMT.x = c(NA, NA, NA, NA, NA), PRCP_AMT.y = c(0,
    0, 0.4, 0.2, 0.2), MEAN_WIND_DIR.x = c(NA, NA, NA, NA, NA), MEAN_WIND_DIR.y = c(0L, 30L, 250L, NA, 50L
    ), MEAN_WIND_SPEED.x = c(NA, NA, NA, NA, NA), MEAN_WIND_SPEED.y = c(0L, 17L, 3L, NA, 24L), MAX_GUST_DIR.x = c(NA, NA, NA, NA, NA, MAX_GUST_DIR.y = c(0L,
    30L, 270L, NA, 40L), MAX_GUST_SPEED.x = c(NA, NA, NA, NA, NA), MAX_GUST_SPEED.y = c(0L, 23L, 5L, NA,
    29L)), row.names = c(2L, 3L, 5L, 11L, 13L), class = "data.frame")

Problems with the results:
1) Columns that fail the match in the primary dataset are deleted.
2) The column that should be populated with the data is instead duplicated to PRCP_AMT.x and PRCP_AMT.y.
3) Unwanted columns are added to the primary dataset during the match (HIGH_PRCN_LAT).

A: for issue 1) you can just add all.x = T :
primaryDataFrame <- merge(x = primaryDataFrame, y = supportingDataFrame1, by = c("SRC_ID", "OB_END_TIME"), all.x = T)

For issue 2)  then the merge is happening as to be expected. You have duplicate columns because they are called the same - you should give them different names and select / rename the one you wish to keep.
You can drop a column for 3) thus:
primaryDataFrame <- merge(x = primaryDataFrame, y = supportingDataFrame1, by = c("SRC_ID", "OB_END_TIME"), all.x = T) %>%
    select(-HIGH_PRCN_LAT)

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Using your donations as efficiently as possible - SAVE THE FROGS!
SAVE THE FROGS! is proud to announce that in 2013 we used over 90 percent of our incoming donations on amphibian conservation programs. That is much higher than the average nonprofit! We'll have our 2014 financial data posted online soon.
To help continue these programs, please donate and consider setting up a monthly recurring donation. The frogs will appreciate it!


With great interest and talent for singing and dancing, Miss Faith started her early career at the age of sixteen, in the music industry as a member of a successful girl band. Recently celebrated 10 years anniversary. They toured around the Netherlands with dance/music acts. Miss Faith her stage experience is really huge, more than thousand performances till today. It`s not hard to understand she`s born to perform.
Her strategic choice to make music herself, by doing and doing, forms the ultimate guarantee for the future. Being productive will surprise the dance floor positively, but always recognizable. Undeniable Miss Faith.
In the start of 2016 she took another step forward by signing up with Dutch Entertainment Group BV for her Management.
Miss Faith is constantly searching for new collaborations, there are no boundaries, music is the/her universal language. You understand, or you don`t. She does!


Metabolic changes induced by oncogenic drivers of cancer donate to tumor growth and so are appealing targets for cancer treatment. malignancies. (phosphatase and tensin homolog removed on chromosome 10) Plinabulin is among the mostly mutated tumor suppressors and it is a fulcrum of multiple mobile features (6,7). PTENs canonical function is really as a lipid phosphatase for phosphatidylinositol-3,4,5-trisphosphate, central towards the phosphoinositide-3 kinase (PI3K) pathway, restricting AKT, mTOR, and RAC signaling Rabbit Polyclonal to ABCC3 (8C11). Inactivation of PTEN enhances blood sugar fat burning capacity and diminishes DNA fix and DNA harm checkpoint pathways (12C14). Furthermore, lacking homologous recombination in PTEN mutant cells network marketing leads to awareness to gamma-irradiation and PARP inhibitors (13,15). The function of PTEN in fat burning capacity, however, is normally incompletely known, and in this research we look at the metabolic implications of PTEN reduction and the causing vulnerability of PTEN mutant tumors. LEADS TO better understand the partnership between PTEN, cell development, and cellular fat burning capacity, we produced flox/flox principal mouse embryonic fibroblasts. WT and KO MEFs (one-way ANOVA, *p .0001, n=3). (B) MEFs tagged with EdU. Representative confocal microscopy pictures. (C) Quantification of Fig.1B (Learners WT and KO MEFs in mass media containing complete glutamine (6mM) or zero added glutamine (one-way ANOVA, *p .0001, n=3). (F) MEFs treated with 12.5nM CB-839 or control (one-way ANOVA, *p .0001, n=3). (G) Comparative metabolite concentrations of DNA nucleotide precursors (dGMP was struggling to end up being measured therefore dGTP was utilized) (Learners pyrimidine synthesis intermediates (Learners pyrimidine synthesis pathway. Don't assume all intermediate was assessed inside our mass spec -panel. Data proven as means + SD. Upon assessment the potential function of glutamine for detailing the increased development of pyrimidine synthesis pathway in pyrimidine synthesis in mammals may be the transformation of dihydroorotate to orotate, catalyzed by dihydroorotate dehydrogenase (DHODH) (17). To find out if orotate plays a part in the growth results observed, the result of DHODH inhibitors on cell proliferation was analyzed. WT and KO cells treated with dosage titrations of leflunomide, A771726, or brequinar to determine GI50s (Learners mutant MEFs. (H) Cells treated with 50M leflunomide in conjunction with 0 or 640M orotate. Confluence of cells after 5 times of treatment was assessed (Learners H1047R) and Myc-CaP (homozygous deletion triggered better AKT phosphorylation than missense mutation do. This was especially prominent in the nuclear fractions, where AKT may phosphorylate nuclear substrates (Fig 2G; Supplementary Fig. S3, ICJ). To separately check if DHODH inhibition can be harmful to PTEN lacking cells, we performed a save test out orotate, the metabolite straight downstream of DHODH, aswell much like uridine. Plinabulin Raising concentrations of orotate or uridine rescued development inhibition by leflunomide (Fig. 2, H-K; Supplementary Fig. S4, ACC). Furthermore, siRNA against DHODH preferentially wiped out PTEN mutant cells, verifying that DHODH was the prospective of the tiny molecule inhibitors (Supplementary Fig. S4D). There is no endogenous difference in DHODH proteins level between and WT MEFs, and A771726 didn't affect PI3K signaling (Supplementary Fig. S4, ECF). In keeping with prior reviews, CAD phosphorylation downstream of mTORC1 was improved in cells, most likely adding to the press of glutamine flux in to the pyrimidine synthesis pathway (Supplementary Fig. S4, GCH) (5). cells had been more delicate than WT cells towards the mTOR inhibitor RAD001 needlessly to say, but RAD001 didn't synergize with leflunomide (Supplementary Fig. S4, ICK) (10,23). Oddly enough, treatment with nucleotide analog inhibitors C Plinabulin 5-flurouracil or mercaptopurine C didn't display a differential level of sensitivity, demonstrating that MEFs are selectively susceptible to inhibition of pyrimidine synthesis (Supplementary Fig. S4, LCM). Myc activation may cause glutamine craving (4). Cover8 (into pyrimidines that's essential (Supplementary Fig. S3D). While MYC may largely immediate glutamine towards the TCA routine and phospholipid synthesis (4), our data claim that reduction in MEFs causes glutamine to Plinabulin cascade through the pyrimidine synthesis pathway, creating the idea of vulnerability to DHODH inhibition. To regulate how medically relevant leflunomide could be being a targeted cancers therapy, we grew patient-derived glioblastomas as 3-dimensional neurospheres. Re-formation of neurospheres was inhibited at lower concentrations of leflunomide in PTEN lacking examples (Fig. 3A; Supplementary Fig. S5A). Additionally, we treated two PTEN mutant triple detrimental breast cancer tumor xenografts with.


BIRMINGHAM, Ala. (AP) Florida will be without kick returner Andre Debose and defensive tackle Darious Cummings for the Birmingham Bowl against East Carolina.
Neither player made the trip for Saturday's game.
Interim coach D.J. Durkin says Debose, a sixth-year senior and one of the nation's top kick returners, came to a ''mutual agreement'' with coaches.
Durkin says Debose is ''moving on with his career.'' Cummings, the team's starting nose tackle, was suspended for violating team rules.
Cummings also was suspended to open the season against Idaho and was reinstated even though the game was canceled because of weather.


MUNICH – Women with cardiac disease who became pregnant had a nearly 100-fold higher mortality rate, compared with pregnant women without cardiac disease, according to the outcomes of more than 5,700 pregnancies in an international registry of women with cardiac disease.
In addition to increased mortality, women with cardiac disease who become pregnant also had a greater than 100-fold higher rate of developing heart failure, compared with pregnant women without cardiac disease.
Despite these highly elevated relative risks, the absolute rate of serious complications from pregnancy for most women with heart disease was relatively modest. The worst prognosis by far was for the 1% of women in the registry who had pulmonary arterial hypertension at the time their pregnancy began. For these women, mortality during pregnancy was about 9%, and new-onset heart failure occurred in about one third. Another subgroup showing particularly poor outcomes were women classified with WHO IV maternal cardiovascular risk by the modified World Health Organization criteria, which corresponds to having an "extremely high risk of maternal mortality or severe morbidity," according to guidelines published in the European Heart Journal (2011 Dec 1;32:3147-97).These women, constituting 7% of the registry cohort, had a 2.5% mortality rate during pregnancy and a 33% incidence of heart failure.
Across all women with cardiac disease enrolled in the registry, the incidence of death during pregnancy was 0.6% and the incidence of heart failure was 11%. Women without cardiac disease have rates of 0.007% and less than 0.1%, respectively, Jolien Roos-Hesselink, MD, said at the annual congress of the European Society of Cardiology.
"The most important message of my talk is that all patients should be counseled, not just the women at high risk, for whom pregnancy is contraindicated, but also the women at low risk," who can have a child with relative safety, she said. "Many women [with cardiac disease] can go through pregnancy at low risk." Counseling is the key so that women know their risk before becoming pregnant, stressed Dr. Roos-Hesselink, a cardiologist at Erasmus Medical Center in Rotterdam, the Netherlands.
Pulmonary arterial hypertension of any cause.
Severe systemic ventricular dysfunction (a left ventricular ejection fraction of less than 30%) or New York Heart Association functional class III or IV.
Previous peripartum cardiomyopathy with any residual impairment of left ventricular function.
Severe mitral stenosis or severe symptomatic aortic stenosis.
Marfan syndrome with the aorta dilated to more than 45 mm.
Aortic dilatation greater than 50 mm in aortic disease associated with a bicuspid aortic valve.


text:
Hilary Minc (né le  à Kazimierz Dolny et mort le  à Varsovie) est un dirigeant communiste polonais, ministre de l'Industrie et numéro trois du Comité central du Parti ouvrier polonais (PPR), responsable de l'économie et de la planification pendant le règne stalinien en République populaire de Pologne après la fin de la Seconde Guerre mondiale.

Il forme avec Bolesław Bierut et Jakub Berman la sinistre « troïka » des communistes polonais qui dirigent la Pologne d'après-guerre.

Biographie

Hilary Minc naît dans une famille juive de la classe moyenne ; ses parents sont Oskar Minc et Stefania née Fajersztajn.

Sa femme Julia Heflich (1901-1987) est la tête de l'Agence de presse nationale (Polska Agencja Prasowa, PAP) jusqu'en 1954. Le mariage n'a pas eu d'enfants.

Il est enterré à l'Allée d'honneur au cimetière militaire de Powązki.

Député de la Ire législature de la Diète de la république populaire de Pologne
Personnalité du Parti ouvrier unifié polonais
Naissance en août 1905
Décès en novembre 1974
Décès à 69 ans
Décès à Varsovie
Histoire de la Pologne
Communiste
Stalinisme
Récipiendaire de l'ordre de la Guerre patriotique, 2e classe
Récipiendaire de l'ordre de la Croix de Grunwald

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