I recently noticed that on Windows, the USB audio interfaces I use have adjustable buffer sizes analogous to PD's block size (I don't see a corresponding control in OS X though). The default value varies from 64 for the Yamaha/Steinberg USB driver to 512 for the MOTU Audio Console. I wrote a PD patch that does nothing except pass input to output and verified that smaller audio interface buffer sizes for the MOTU result in a proportionally lower input to output latency. It looks like that latency contains some additional overhead (~7mS) not accounted for by the PD delay, PD block size, and audio interface buffer size. What accounts for the additional overhead? Is there any interaction between PD block size and audio interface buffer size? Is there a better way to choose the optimal audio interface buffer size than trial and error? Does that size depend on the specifics of your PD patch?
Generally, the "blocksize" in the audio setting really is the hardware buffer size and not Pd's global blocksize (which is always 64 samples).
Modern ASIO drivers are multiclient which means that the device can be used by more than one app at the same time. When you set the buffer size in your device app (e.g. Focusrite MixControl) this will set the internal blocksize and consequently the minimum latency possible for all clients. Usually you would want to set the internal buffer size as low as possible (without getting audio glitches).
Individiual clients (e.g. a Pd instance) can request a buffer size from the device. This can't be smaller than the above mentioned internal buffer size, but it can be larger (if you need extra latency). Most DAWs control the latency via the buffer size while Pd has it's own buffering mechanism ("delay").
Note that for Pd the hardware buffer size affects the overall timing resolution (when DSP is on). Pd will calculate several blocks of 64 samples as fast as possible until it has enough samples to send to the device. If the hardware buffer size is 256, Pd will calculate 4 blocks in a row (4 * 64 = 256) and then wait until the device asks for another 256 samples. This causes jitter! (Try [bang~] with [realtime] and [print] to see it yourself). The lower the hardware buffer size, the less jitter you get, so generally it's better to keep "blocksize" as low as possible and rather increase "delay" if you need more latency.
BTW, in case of old single client ASIO drivers, "blocksize" would directly set the hardware buffer size of the device. This is still the case e.g. with ASIO4ALL.
Thanks. I verified that the blocksize chosen under Audio Settings doesn't affect PD's global blocksize, which is surprising. But I'm trying to understand what you mean about jitter. Is this the test you're suggesting?
If so, I get similarly jittery results no matter what Audio Settings block size I choose. But more to the point, isn't this "jitter" irrelevant? It's just a function of how fast the computer processes each block, what else it has to do concurrently, and how frequently it has to fill the audio interface's output buffer. The fact that each block is processed at irregular intervals isn't necessarily reflected at the audio output, right?


Tonight the Bruins will finally get started on their playoff hockey journey. The team standing in their way for round one is the Detroit Red Wings. This will be the eighth time these teams have faced off in the postseason with the Bruins having a slight edge of 4-3. If you can't remember the last time the teams met in the playoffs, that's okay because it was in 1957.
The matchup against the Red Wings will be a good one to say the least. Although the Red Wings were the last team to make it into the Eastern Conference side of the bracket, they are the only team who has beaten the Bruins 3 times this season. Looking back at the 4 times these teams faced each other this season, it is hard to really gather too much insight into how these teams stack up against each other. The first two games came in early October before either team really had an identity. The Bruins won the first matchup 4-1 while the Red Wings took the second 3-2. The next game came on November 27th when the Bruins were routed by a score of 6-1 in Detroit.
In those first 3 games, there was one constant for Detroit and that was the scoring of Henrik Zetterberg. In all 3 contests leading up to the Olympic Break, Zetterberg had at least one goal when playing the Bruins. Zetterberg was one of the NHL stars who was injured while participating in Sochi. If he does return to the Red Wings this season it will not be in round 1 of the playoffs.
The most recent time the Bruins faced the Red Wings was on April 2nd in Detroit. Detroit was playing playoff hockey to continue their postseason appearance streak, while the Bruins were faltering after having their wining streak snapped. Although the Bruins put the puck on net 35 times, Jimmy Howard was putting on a clinic in net for the Red Wings. The Red Wings would score the tying and game-winning goals midway through the 3rd period to prevent the Bruins from continuing on their point streak.
Looking at every team statistic, the Bruins have an advantage over the Red Wings. They score more often on the power play and are more effective on the penalty kill. They average 3.15 goals per game while the Red Wings average 2.65. When it comes to goals allowed, the Bruins average 2.08 to the Red Wings' 2.70.
Other than the fact that this is playoff hockey and the team who wins is one step closes to the cup, a storyline worth being up to speed on is the sibling rivalry angle. Bruins' RW Reilly Smith will be playing against his brother defenseman Brendan Smith. Reilly has has played well against Detroit this year and have notched an assist in every game. On the season Reilly has played in all 82 games scoring 51 points. Brendan has played in 71 games this season and scored 5 goals to go along with his 14 assists. Brendan played in 14 playoff games last season and scored 2 goals and 1 assist from his defensive position.
Unlike other people, I'm going to predict a 5 game series with the Bruins coming out on top. Specifically, I'm predicting the Bruins to win both games this weekend and then lose the first game in Detroit.


text:
Trapdoor Tapes 2015 / 2016 batch
Posted on May 26, 2016 by noisereceptor
The first tape for review sees two obscure Australian projects Mshing and Sentenced to Life team up to each take a side of the tape each. Mshing is the solo project of Luke Holland (also of Armour Group) and delivers a live recording or as it is referenced on the cover 'Live Assault 2015/2013'. Commencing with a cyclic death industrial throb it hits an early groove, but then moves into more obscure grinding noise industrial territory with semi-buried samples and gruff vocalizations. While the track is decent enough, with the distant muffled sound of the recording it only serves to hint at the actual live performance/s being of far greater volume and sonic impact. Sentenced for Life take up the flip side, with the single track 'Despertar De La Bestia' and presents an atmospheric 'post-mortem' soundscape of muffled layered analogue filth. Featuring a broadly cyclic approach, there is an interweaving interplay between the layered elements which generates an excellent complexity of rumbling industrial distortion, revving drones, distant sirens, cavernous clatter and indistinguishable voices. This is both a strong track and the highlight of this tape given its murky and immersive qualities.
On the 'Stir' MC, Luke Holland goes it alone (again) but here functioning under his own name. Compared to the last solo tape 'Decomposition', this time around he has taken a rougher, a more caustic industrial-noise approach. With the single 16 minute track (repeating on both side), the squalling mid to high pitched chaotic noise is coupled with a deluge of dialogue samples. Featuring a sense of improvised urgency the samples are then taken from Australian 1980s film 'Stir', referencing prison life, outsider attitude and cut throat violence. Some ritualistic clanging elements change up the sound mid piece to offset the more intense and sustained background distortion, while the piece bleeds out into looser, scattered abstract across the last section before abruptly cutting out. Noting the driving urgency this tape of greater impact that than the 'Decomposition' recording.
Lastly, the World of Life Church SS tape features 5 untitled tracks in all, the first track being driven by a direct militant industrial 'beat', around which scattered noise and distortion interweave, all capped off with barked/ spat distorted vocals. Rough and direct it is an excellent opening, while later tracks are broadly looser and more chaotic in their rough analog approach: essentially charting a course in a broad spheres relating to scattered noise-industrial to overblown power electronics squall. With a sound which is a perfect fit for the obscure sounds Trapdoor Tapes is known, this delivers strong results, although admittedly it sounds more like a solo or duo project, than otherwise might be expected from a project featuring 4 members.
Posted in 2015, 2016, death industrial, industrial, post-mortem, Trapdoor Tapes	| Leave a reply
Dead Letters Spell Out Dead Words – No Words
With Trepaneringsritualen now being a widely recognized name within the industrial underground, prior to the launch of that project in 2008 sole member Thomas Martin Ekelund recorded under another style and moniker, namely Dead Letters Spell Out Dead Words ('Dead Letters' for short). With Dead Letters being broadly bracketed under the genres of drone and dark ambient, the music is also more musical than those genre classifications might imply. As for 'No Words' it a re-release of a 2010 tape featuring 3 lengthy tracks, which span an album's worth of material (43 minutes).
On the musical front although being sonically lighter than the rather imposing ritual death industrial works of Trepaneringsritualen, conversely Dead Letters can be considered as being emotionally heavier than Thomas' current project. As such there is a real sense of melancholy and emotional desolation which weaves through the music, and which draws the listener deep within the confines of its depressive atmosphere.
The first side of the vinyl bring two separate 10 minute tracks under the same title of 'No Words'. Based on their combined title, these pieces are obviously instrumental, where the first track features a spartan (clean) guitar tune, with plodding bass and sparse, tonally shimmering dark ambient undercurrent. With an almost ambient 'post-rock' edge, the sense of melancholy and desolation is far greater than typical music of that genre, but mid track the mood builds to a sort of doom addled synth based crescendo. The second track on Side A ebbs forward at a crawling pace as gradual drone layers are added, where later a layered drone guitars evoking a bittersweet melody of doom creeps into frame (…"crushingly uplifting" might be suitable oxymoron to use). Side B delivers the single LP sided track 'Forgive/ Forget/ Regret', which spans 23 minutes. Commencing very much as a sparse doom-drone track, of atonal bass thuds, it catatonically builds upon a sparse undercurrent of shifting ice like static. Well into the second half a miserably depressing guitar line emerges into frame, along with a slow cyclic rhythmic pulse, and melodic synths to give a greater sense of song structure and movement, which continues through to the conclusion of the piece. Desperately and depressively sublime….
Given that Dead Letters back catalogue has in some way been overshadowed by Trepaneringsritualen, Cloister Recordings US should be commended for digging this release for a vinyl reissue treatment. On the visual front the artwork visually articulates the emotional desolation found within, whilst the mastering courtesy of James Plotkin has perfectly polished the musical content for a new audience. Being almost needless to say, this is a great release.
Posted in 2016, dark ambient, doom drone, drone, experimental, post rock	| Leave a reply
Jarl – Amygdala Colours – Hemisphere Rotation
Following the epic 2 x CD 'Case 1959' from 2015 (reviewed here), Jarl returns in 2016 with a single CD featuring one track at 56 minutes in length. On the thematic front, Jarl has conceptual moved from 'external' influencing concepts, to matters of the 'interior' and I quote: "electronic and acoustic sounds for the processing of memory, decision-making, and emotional reactions. For the left sides of Amygdala".* With this thematic underpinning, the use of concepts in dark ambient music warrants comment given it provides a 'thinking' element to latch on to when listening. This has been positively demonstrated on recent Jarl albums, where there has been a strong thematic underpinning for each, even if 'technically' speaking the sonics do not vary widely between albums. Yet in such examples as Jarl, personally I see the use of theme as a bonus, by constituting an 'idea' to contemplate and turn over in one's mind when listening to the album.
But with all that is said on use of themes above, even if you were to ignore any conceptual trappings, the music here can stand on its own as an immersive and contemplative experience. Likewise by now with the number of albums released under the Jarl banner, there is likely to be a general appreciation of what is to be expected – and that being an album of minimalist dark ambient soundscapes and slow morphing sonics which balances on an edge between the clinical and darkly tinged. Given the single lengthy composition an elongated approach has again been adopted, which by very nature slowly evolves throughout. Clinical, multi-layered drones ebb and flow, where there is a refined level of attention to sonic detail (…given then is upwards of half a dozen individually discernible layers at any one time). Essentially it amounts to tonal soundscape constructed around shimmering drones, pulsing/ throbbing elements and other various textural layers are constantly shifting, intertwining and evolving (…and on occasion partially replicating discordant orchestral strings). Tonally deep and 'hollow', there is also a bulk, thickness and clarity to the production, which again provides an enveloping listen (…and particularly so when listening to this through headphones).
As with all of Jarl's output I have heard, I certainly enjoy the experience, although I would be hard pressed to say this is comparatively better (…or worse?) than anything else I have heard from the project. So if you know and like Jarl based on previous output, this will deliver an expected and enjoyable listen, yet equally, if Jarl is simply not known, this is as good a place to start. Finally the mini-gatefold cardboard cover, with photography by Karolina Urbaniak is suitably abstract to suit the soundscapes found within.
* – The 'amygdala' is an almond-shape set of neurons located deep in the brain's medial temporal lobe, which play a key role in the processing of emotions, and linked to fear and pleasure responses. In humans and other animals its size correlates with aggressive behavior across species, and in humans has been noted to shrink by more than 30% in males upon castration. Conditions such as anxiety, autism, depression, post-traumatic stress disorder, and phobias are also suspected of being linked to abnormal functioning of the amygdala.
Posted in 2016, dark ambient, experimental, Reverse Alignment	| Leave a reply
Last Dominion Lost – Snowdrops from a Curate's Garden
Posted on May 5, 2016 by noisereceptor
There is little room to avoid the fact that the release of this record in late October, 2015 was overshadowed by the untimely passing of core project member John Murphy on 11 October, 2015. Yet conversely the album now functions as a fitting tribute to John, as an ardent underground figure who never abandoned his personal drive for musical expression within industrial and experimental musical spheres. Whilst this album is technically not a new studio recording (it is the result of a live recording from 2011), you would never guess this from the sound alone, as there production is clean and clear and there is no background crowd noise (…perhaps being removed from the mix when undergoing mastering by luminary James Plotkin). The fact that the live set also consisted of exclusive and up until now unreleased material, further sets it apart from a 'typical' live recording.
When contemplating the diversity and refinement of material found on the 'Towers of Silence' LP from 2014 (reviewed here), the music on 'Snowdrops from a Curate's Garden' (name borrowed from the title of an Aleister Crowley book), has a more direct and consistent approach, which is slightly rougher and looser in execution (…thereby reflecting the live nature of the recording). Thus across the 8 tracks (…40 minute approx. play time), there is definite singularity to its style and sound, which is evidenced through the use of weird tonal vocal treatments, where spoken/ chanted vocals (or vocal samples?) and mangled into a garbled and schizophrenic 'hearing voices' type style. It also broadly contains that particular disorientating and 'wonky' 1980's industrial sound which Last Dominion Lost have made their own. Swirling miasma of dissociative and disorienting electronics, metallic derived clatter, industrial/ ritual/ martial percussion and the aforementioned vocals intermingle into an (abstract) industrial sonic soup. Cascading avalanche of loose militant to ritualized percussive and metallic textures also feature alongside twisting and morphing analog electronics. Very much with its basis in a classic industrial frame of reference, there is also clear nods to ritual aesthetics with the wailing ritual horns and driving percussion.
Although I initially assumed 'Snowdrops from a Curate's Garden' might be Last Dominion Lost's swansong release, this is not the case. Evidently the other core project member Jon Evans and Julian Percy have now been joined by earlier guest collaborator Till Brüggemann and have decided to forge ahead, where work on the new album has commenced. Given that John's sonic contributions hold a very strong influence over Last Dominion Lost's sound (and in particular with reference to his twisted analog electronics and distinctive percussive style), it will be intriguing to hear what the new album with his absence will bring. But for now, 'Snowdrops from a Curate's Garden' stands as a fitting celebration of John Murphy's dedication to the industrial underground.

redpajama_set_name: RedPajamaCommonCrawl


Create your own luck. Don't wait for internships to be advertised as you'll be competing with everyone else.
Start small. Think about a sector or job that interests you and who you know working in those areas. Ask if you can shadow them or do a couple of days' work experience. Write directly to local companies and ask if they will let you come in and observe.
Build on the connections you make with the above companies. Start applying for advertised internships on their websites, or continue approaching people directly.
Use LinkedIn or other social media to find possible contacts.
If you're a Level 1 student look into our Widening Participation Internship Scheme (WPSIS) - an eight week, fully paid summer internship scheme for eligible students.
Placements help you to gain the all-important hands-on industry experience that is directly relevant to your degree. Contact your Placement Adviser to find out more and to check whether your course offers a placement.
Volunteer with Brunel Volunteers, on campus or elsewhere. It's a great way to develop office skills and experience of working with specific communities.
Ask your careers consultant how to approach firms directly.
Don't expect to be paid, especially at first and in certain sectors, such as media and politics.
Investment banking, for example, expects interested applicants to do Spring Weeks and summer internships, starting at the end of your first year. Look out for these towards the end of Term 1.
Law asks for experience in a law firm, or to have visited a local court for examples.
The media and politics sectors expect some level of work experience too, as this shows interest and determination.
Medicine requires experience of a medical environment, e.g. National Health Service (NHS) or similar clinical setting, care home or hospice. Visit Medschools Online for suggestions.
In 2016, 64% of students joining university had already undertaken part-time work. Part-time work, of any kind, is valuable experience and should be present on your CV.
Think of the skills you've developed while working, but also speak to your manager about getting some experience at your employer's head office - in the HR, finance or marketing department for example.
If you are unsure where to start looking, or you feel you are not finding the right opportunities, come in and talk to a Careers Consultant.
When you are ready to apply you will need a good CV, so look at our examples for different subjects and sectors, and then visit the PDC to get advice on presentation and content, and to identify possible gaps in your experience.
Please check the opportunities in these links carefully and, where work is unpaid, try to ensure you are not being exploited. Come in and talk to a Careers Consultant if you would like some help deciding if an opportunity is right for you.
The Professional Development Centre always encourages employers to pay the national minimum wage (NMW) or above unless they are a charity and legally exempt. While we recognise that in some industries unpaid work experience is considered normal practice we will not advertise these vacancies.
Match your skills and personal qualities to the job requirements. Market yourself by selling yourself as a solution to the employer's requirements. Target your attributes to appeal to them.
Many large organisations have deadlines for vacation schemes in autumn or early spring. Remember to check websites so that you don't miss these opportunities.
Consider small and medium sized enterprises (SMEs) as the work can be very varied giving you all-round experience. SMEs may only recruit occasionally – research and networking will help you identify these jobs.
Many vacancies are never advertised. Put together a list of organisations that you feel will offer the right kind of experience but are also likely to need your skills.
Other resources, e.g. Equality and disability, are listed in the How can I get help? section.
Use the resources in our Working Internationally section to look for internship or other opportunities. Start your search early as you may need to organise a visa.
Employers hate 'round robin' applications - where students cut and paste the name of the company without adapting what they write. Currently, more companies say they will almost certainly reject applications that do not demonstrate authenticity and real passion for their business. Applications need solid research, planning and a focused strategy. Employers may receive hundreds of applications per advertised position, so make yours special. Treat each application as if it is your only one.
Recruitment fairs are held throughout the year at various universities. Employers set up a stand, usually bring graduate trainees, answer questions about their companies, and give details of available vacancies (generally graduate or sandwich placements). It's also an opportunity to ask about possible work experience opportunities. Careers fairs at other universities are listed on the Prospects website.


FREMONT, CA — June 13, 2017 — Dataguise, a leader in data-centric audit and protection (DCAP), today announced that the company is a Bronze sponsor of the 2017 DataWorks Summit, taking place June 13-15 in San Jose. With less than a year before the General Data Protection Regulation (GDPR) comes into force for organizations conducting business with residents of the European Union (EU), Dataguise experts will be on hand to engage and advise event attendees on the direct actions necessary to discover, protect, audit, and monitor personal data in Hadoop and other data repositories in order to comply with the mandate's data privacy requirements.
The DataWorks Summit is the industry's premier big data community event, providing those attending the conference with the opportunity to learn from peers and industry experts on how open source technologies enable organizations to leverage corporate data, on premises and in the cloud, to drive predictive analytics, distributed deep-learning, and artificial intelligence initiatives. Dataguise plays a key role in this mission by providing organizations with the ability to fully utilize corporate data without the risk of exposing sensitive information contained in Hadoop and other data repositories on-premises and in the cloud.
During the event, Dataguise will showcase DgSecure, the company's flagship data-centric audit and protection solution that delivers a single view of sensitive data security, policies, access, and trends for risk and compliance management—all from a single dashboard. Recent enhancements to the platform include: sensitive data monitoring for MapR, Oracle Database, and Teradata; Cloudera Navigation for Hive; structured encryption and decryption for European languages; and an enhanced REST API for multi-cloud service interoperability.
DgSecure supports IT, business, and legal professionals concerned with data privacy regulations currently on the books or that will see implementation over the next year. The software locates all sensitive data across distributed business environments and provides encryption, masking, auditing and monitoring to support Hadoop distributions and other data in structured, unstructured, or semi-structured repositories. This is especially relevant to organizations with citizen data from the European Union (EU), which will soon be subject to the Supervisory Authorities (SAs) of the General Data Protection Regulation (GDPR) who may impose fines of up to 2% of total global revenue or €10M (whichever is greater) for initial violations of non-compliance.
Learn more about Dataguise DgSecure's support for GDPR compliance by visiting http://www.dataguise.com/general-data-protection-regulation-gdpr-compliance.


Farmers Insurance - Ryan Hays can be found at 20860 N Tatum Blvd . The following is offered: Insurance, Car Insurance, Life Insurance, Home Insurance . In Phoenix there are 787 other Insurance. An overview can be found here.


text:
5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis
Su Wenjuan, Yeku Oladapo, Srinivas Olepu, Alyssa Genna, Jae Sook Park, Hongmei Ren, Du Guangwei, Michael H. Gelb, Andrew J. Morris, Michael A. Frohman
The signaling enzyme phospholipase D (PLD) and the lipid second messenger it generates, phosphatidic acid (PA), are implicated in many cell biological processes, including Ras activation, cell spreading, stress fiber formation, chemotaxis, and membrane vesicle trafficking. PLD production of PA is inhibited by the primary alcohol 1 -butanol, which has thus been widely employed to identify PLD/PA-driven processes. However, 1-butanol does not always effectively reduce PA accumulation, and its use may result in PLD-independent deleterious effects. Consequently, identification of potent specific small-molecule PLD inhibitors would be an important advance for the field. We examine one such here, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI), which was identified recently in an in vitro chemical screen for PLD2 inhibitors, and show that it rapidly blocks in vivo PA production with subnanomolar potency. We were surprised to find that several biological processes blocked by 1-butanol are not affected by FIPI, suggesting the need for re-evaluation of proposed roles for PLD. However, FIPI does inhibit PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis, indicating potential utility for it as a therapeutic for autoimmunity and cancer metastasis.
https://doi.org/10.1124/mol.108.053298
10.1124/mol.108.053298
Dive into the research topics of '5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis'. Together they form a unique fingerprint.
Phospholipase D Biochemistry, Genetics and Molecular Biology 100%
Phosphatidic Acid Biochemistry, Genetics and Molecular Biology 62%
Chemotaxis Biochemistry, Genetics and Molecular Biology 37%
Butanol Biochemistry, Genetics and Molecular Biology 37%
Cell Spreading Biochemistry, Genetics and Molecular Biology 37%
Biological Phenomena and Functions Concerning the Entire Organism Biochemistry, Genetics and Molecular Biology 25%
Biological Product Pharmacology, Toxicology and Pharmaceutical Science 25%
Small Molecule Biochemistry, Genetics and Molecular Biology 12%
Wenjuan, S., Oladapo, Y., Olepu, S., Genna, A., Park, J. S., Ren, H., Guangwei, D., Gelb, M. H., Morris, A. J., & Frohman, M. A. (2009). 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Molecular Pharmacology, 75(3), 437-446. https://doi.org/10.1124/mol.108.053298
Wenjuan, Su ; Oladapo, Yeku ; Olepu, Srinivas et al. / 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. In: Molecular Pharmacology. 2009 ; Vol. 75, No. 3. pp. 437-446.
@article{21b3a3b0f8c2453db162b27885ceb27d,
title = "5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis",
abstract = "The signaling enzyme phospholipase D (PLD) and the lipid second messenger it generates, phosphatidic acid (PA), are implicated in many cell biological processes, including Ras activation, cell spreading, stress fiber formation, chemotaxis, and membrane vesicle trafficking. PLD production of PA is inhibited by the primary alcohol 1 -butanol, which has thus been widely employed to identify PLD/PA-driven processes. However, 1-butanol does not always effectively reduce PA accumulation, and its use may result in PLD-independent deleterious effects. Consequently, identification of potent specific small-molecule PLD inhibitors would be an important advance for the field. We examine one such here, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI), which was identified recently in an in vitro chemical screen for PLD2 inhibitors, and show that it rapidly blocks in vivo PA production with subnanomolar potency. We were surprised to find that several biological processes blocked by 1-butanol are not affected by FIPI, suggesting the need for re-evaluation of proposed roles for PLD. However, FIPI does inhibit PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis, indicating potential utility for it as a therapeutic for autoimmunity and cancer metastasis.",
author = "Su Wenjuan and Yeku Oladapo and Srinivas Olepu and Alyssa Genna and Park, {Jae Sook} and Hongmei Ren and Du Guangwei and Gelb, {Michael H.} and Morris, {Andrew J.} and Frohman, {Michael A.}",
doi = "10.1124/mol.108.053298",
Wenjuan, S, Oladapo, Y, Olepu, S, Genna, A, Park, JS, Ren, H, Guangwei, D, Gelb, MH, Morris, AJ & Frohman, MA 2009, '5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis', Molecular Pharmacology, vol. 75, no. 3, pp. 437-446. https://doi.org/10.1124/mol.108.053298
5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. / Wenjuan, Su; Oladapo, Yeku; Olepu, Srinivas et al.
In: Molecular Pharmacology, Vol. 75, No. 3, 03.2009, p. 437-446.
T1 - 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis
AU - Wenjuan, Su
AU - Oladapo, Yeku
AU - Olepu, Srinivas
AU - Genna, Alyssa
AU - Park, Jae Sook
AU - Ren, Hongmei
AU - Guangwei, Du
AU - Gelb, Michael H.
AU - Morris, Andrew J.
AU - Frohman, Michael A.
N2 - The signaling enzyme phospholipase D (PLD) and the lipid second messenger it generates, phosphatidic acid (PA), are implicated in many cell biological processes, including Ras activation, cell spreading, stress fiber formation, chemotaxis, and membrane vesicle trafficking. PLD production of PA is inhibited by the primary alcohol 1 -butanol, which has thus been widely employed to identify PLD/PA-driven processes. However, 1-butanol does not always effectively reduce PA accumulation, and its use may result in PLD-independent deleterious effects. Consequently, identification of potent specific small-molecule PLD inhibitors would be an important advance for the field. We examine one such here, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI), which was identified recently in an in vitro chemical screen for PLD2 inhibitors, and show that it rapidly blocks in vivo PA production with subnanomolar potency. We were surprised to find that several biological processes blocked by 1-butanol are not affected by FIPI, suggesting the need for re-evaluation of proposed roles for PLD. However, FIPI does inhibit PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis, indicating potential utility for it as a therapeutic for autoimmunity and cancer metastasis.
AB - The signaling enzyme phospholipase D (PLD) and the lipid second messenger it generates, phosphatidic acid (PA), are implicated in many cell biological processes, including Ras activation, cell spreading, stress fiber formation, chemotaxis, and membrane vesicle trafficking. PLD production of PA is inhibited by the primary alcohol 1 -butanol, which has thus been widely employed to identify PLD/PA-driven processes. However, 1-butanol does not always effectively reduce PA accumulation, and its use may result in PLD-independent deleterious effects. Consequently, identification of potent specific small-molecule PLD inhibitors would be an important advance for the field. We examine one such here, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI), which was identified recently in an in vitro chemical screen for PLD2 inhibitors, and show that it rapidly blocks in vivo PA production with subnanomolar potency. We were surprised to find that several biological processes blocked by 1-butanol are not affected by FIPI, suggesting the need for re-evaluation of proposed roles for PLD. However, FIPI does inhibit PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis, indicating potential utility for it as a therapeutic for autoimmunity and cancer metastasis.
U2 - 10.1124/mol.108.053298
DO - 10.1124/mol.108.053298
Wenjuan S, Oladapo Y, Olepu S, Genna A, Park JS, Ren H et al. 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Molecular Pharmacology. 2009 Mar;75(3):437-446. doi: 10.1124/mol.108.053298


C&R German belt-fed machine gun – World War I Spandau Arsenal MG08/15 watercooled, belt-fed machine gun. This gun, #7490, is dated 1917 and has seen use. It has light rust on the exterior which would clean up well with a soft bead blasting. Interior of the receiver has been cleaned but shows signs of heavy rust, although internal parts are in good condition. This gun is fully functional. The green paint on the barrel jacket is from the field camouflage applied by soldiers. However, it would look better being cleaned off in the bead blast process.
This Maxim shoots the economical 8mm Mauser ammunition which can be purchased for 5 cents per round, much easier on your pocketbook than 303 British in the Vickers. Externally this gun appears all matching but some internal parts have been replaced with better condition parts. Excellent bore. To make up for the need for bead blasting, this Maxim comes with original drum hanger and original drum! It also comes with cloth belt, although I recommend you purchase steel belts from IMA.
Water coded Maxim machineguns can be fired either with water or dry. Just remember, when firing dry, shoot short bursts and let it cool down every so often. If you want to shoot one hundred round "bursts" or a full belt all at once, use packing string and put water in the jacket.
Reproduction bipod upper attachment brackets are available for $95.00 from several sources. These can be welded to a variety of tripods or mounts to give real versatility to your shooting stance. Also www.blackrivermilitaris.com sells spade grip assemblies for the 08|15 Maxim.
This C&R Maxim machine gun is fully transferable and fully functional. It is C&R listed. Priced at $10,000 Sold in March of 2005 You can call us free at (877) 437-0251 and we will further describe the weapon and answer any questions you might have.


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https://www.theridgefieldpress.com/sports/fciac/article/Ridgefield-girls-soccer-team-begins-state-title-14004773.php
Ridgefield girls soccer team begins state title defense with 4-0 win
Published 2:24 pm EST, Tuesday, November 6, 2018
There was no letdown.
Four days after winning its third conference championship in four years, the Ridgefield High girls soccer team began defense of its Class LL state title with a 4-0 victory over Manchester in a first-round game Monday at Tiger Hollow.
Ridgefield, the seventh seed, will now host 10th-seed South Windsor in a second-round contest Wednesday at 4. The winner advances to the Class LL quarterfinals against either second-seed Suffield or 18th-seed Darien.
The Tigers (17-2-1) were dominant from the beginning of Monday's game against 26th-seed Manchester, using their assertiveness to create early scoring chances. A shot from Tasha Riek knocked into the post and rebounded to Caitlin Slaminko, who sent her shot off the opposite post.
Minutes later, the two players combined for Ridgefield's first goal, with Slaminko scoring on an assist from Riek.
The Tigers had more than a dozen shots and seven corners before they scored their second goal, which came with 16 minutes left in the second half. Faith Arnold got the goal, curving a corner kick directly into the Manchester net.
Ridgefield then found its groove, scoring two more goals in under 10 minutes.
Riek made it 3-0 with a stunning shot from about 20 yards away. "When attempting [long] shots it's always just about trying to put it on frame and following through," said Riek about the goal.
Megan Klosowski got Ridgefield's fourth goal a few minutes later off another of Arnold's corner kicks.
Defenders Claire Middlebrook, Amelia Hynes, Carrina Dabroi, and Carolyn Donovan frustrated Manchester throughout the game, keeping the visitors from scoring.
"I think we work as a cohesive unit," said Donovan. "We always make sure to cover for one another, and when we win possession we are able to play out of the back."


Qns 1. Please guide me regarding deletions made from the Economics syllabus. Please also advise me on the answering pattern, use of graphs and word limit.
Vide Circular No. 15 dated 12.03.2007 the following sub-topics have been deleted from the Economics syllabus for the Board Examination, 2009: In Unit 8: Recent significant reforms and issues in the Indian Banking system- Privatization and modernization.In Unit 9: Downsizing the role of government: meaning and implication.In Unit 10, A brief analysis about recent exchange rate issues.These deletions are also reflected in the Economics syllabus, class XII, 2009 examination.
Details of the circular are available on the CBSE website http://www.cbse.nic.in/circulars/cir1507.doc. For answering pattern and other related issues, please refer to the revised sample question papers in Economics; class XII available on the Board's website www.cbse.nic.in.
Qns 2. What are HOT questions in Economics? Can you give some examples?
Marginal and average cost etc and their relationship.
Concept of equilibrium in microeconomics and in macroeconomics.
Concepts of domestic product and national product.
Concepts of inflation, depreciation of domestic currency, etc.
Just memorizing the meaning of concepts does not help in understanding the subject and the use of these concepts. For instance just memorising the meaning of concepts and their relationship will not help you in answering question, like.
Why must aggregate demand and aggregate supply be equal when the economy is in equilibrium?
Qns 3. How can I get good marks in Economics?
Good marks in Economics can be scored if you prepare for the subject well keeping the Economics syllabus prescribed by the Board as the base. You can also refer to the supplementary material in Introductory Microeconomics and Macroeconomics given on the Board's website http://www.cbse.nic.in/microeconomics%20class%20xii.pdf and http://www.cbse.nic.in/macrofinaljuly14.pdf in addition to NCERT textbooks. Evaluation in Board's examination is done as per marking scheme developed for the question paper.
Please understand the question well and answer accordingly in simple and precise manner. Refer to sample question papers given on the Board's website for greater clarity.
Qns 4. Which is the best book in Economics Class XII for us to refer to for the Board examination 2010? Can we consult private publishers' books?
Every year the Board brings out curriculum in different subjects at secondary and senior school stage for a particular examination year. Teachers and students are advised to follow the concerned syllabus strictly for teaching and examination purpose.
Teachers should refer to those parts of the NCERT Textbooks in Economics Class XII which cover the Economics syllabus and the supplementary reading material provided by the Board on its website http://www.cbse.nic.in. Since the Economics syllabus is almost the same for the last three years, it is advisable to also go through the question papers of last three years' examination (2006-2008) besides the Sample question papers in Economics Class XII for 2009 Examination on the Board's website.
The Board has stopped recommending private publishers books and recommends only NCERT textbooks.
Qns 5. The NCERT textbooks in Economics, class XII contain some topics not prescribed in the CBSE syllabus for 2009 examination. Should we follow NCERT books or the syllabus? Please guide.
Qns 6. What type of papers will come for class XII students?
Please refer to the design of the question paper and sample question papers in Economics which are given on the Board's website http://www.cbse.nic.in/curric~1/sqp-eco-xii-2009.pdf under Students section. The website also contains question papers of 2008 for guidance of students.
Qns 7. The new textbooks in Economics contain too much of Mathematics. Can there be a question on mathematical derivation of a concept or a behavior in the Board Examination?
Economic concepts and behaviour can be explained diagrammatically, mathematically and through explanations. All the three ways are complementary to each other. The Mathematics required in class XII Economics is not higher than that studied in class X. However, for 2009 examination, the Economics syllabus does not require a student to give mathematical derivations in his/her answer. They can give explanation supported by diagrams to explain particular economic behavior/concepts.


Carrie Fisher stars in "Wishful Drinking" Sunday on HBO.
Carrie Fisher, wearing all black, can't quite stay seated in a hotel room. Her people fuss over her, but when left alone, she focuses.
She focuses on a life that seems created for tabloids. She focuses on the gossip frenzy that was her parents' marriage and divorce. The daughter of Debbie Reynolds and crooner Eddie Fisher, Carrie Fisher was what Angelina Jolie and Brad Pitt's children could become if they go into show business, marry and divorce equally famous people, and devolve into a life of drugs and madness.
Fisher, though, is special. She survived the tsunami of Hollywood insanity that has drowned so many others and, in doing so, lives to tell the tale with good humor in the one-woman stage show "Wishful Drinking," airing Sunday, Dec. 12, on HBO.
Though Fisher refers to Pitt and Jolie in her film, she likens her mom more to Jennifer Aniston. Reynolds, the perky blonde of "Singin' in the Rain" among scores of others, was America's sweetheart. Her husband, Eddie Fisher, who recently died, took off with Elizabeth Taylor, and that Hollywood scandal was pretty similar to the Pitt/Aniston/Jolie affair.
Fisher is that rarity -- self-aware and self-mocking. She's funny and deals with the fact that though once a poster girl for every nerd who fantasized about her in that bikini from "Star Wars," she's now a stocky, middle-aged woman.
"Everything else is going really well, so I give myself a problem," Fisher says of her weight. "Or I could kill myself and look like Demi Moore. I hate that it matters. It does because I am a public figure and people get so down on me."
She was recently looking up something on the Web and came across a posting: "I wonder what ever happened to Carrie Fisher," she quotes. "She used to be so hot and now she looks like Elton John."
"I wrote back that I didn't realize when I donned the metal bikini at 19, I made a contract to look the same for 40 years," she says. "You have not been invited to look at my house. You have been invited to listen to my fountain. I got to the point where I got so heavy. I'm very clear about what I'm confident about. I know what I know, and I know I have a gift.
"I am taking down dictation from something in me that urgently wants to be expressed," she continues. "I have been doing that since I was 14."
She pops up out of a wing chair as if it's electrified, talking about "compulsively reading and writing." Fisher, like any true Dorothy Parker fan, can recite her poems. Fisher reflects on being a bookish kid, gazing adoringly at her movie star mom.
"I looked up at Debbie Reynolds," Fisher says. "Blond, green eyes, beautiful teeth and graceful. Her thing is to be a movie star. She walks like a queen."
With that Fisher pretends to float across the hotel room. "And I walk like this," she says, stomping across the room so loudly, the carpet barely muffles her steps.She perches on the edge of the chair only to pop back up.
"My mother grew up white trash in Texas," she says. This isn't quite the image usually associated with the glamorous Miss Reynolds, but Fisher lacks the filter most people have between their brain and mouth; it's part of her charm.
"I was just thinking last night, 'I've had all these experiences. What the f--- was I doing?' " she says, apropos of nothing. "I stayed with the Kennedys once. I didn't feel like I deserved to be there. I felt like this show-business schlump, and they are blue bloods."
Fisher realizes that she always had the writer's ability to observe life as it unfolded.
The propulsion behind writing the amusing book, which led to a traveling stage show that was eventually filmed for the HBO special, was to help recapture lost memories. Drugs and electroconvulsive therapy had toyed with her recollections.
"I emerge from my three-week-long ECT treatment to discover that I am not only this Princess Leia creature but also several life-sized dolls, various T-shirts and posters, some cleaning items, and a bunch of other merchandise," Fisher writes.
Yet she endures it all and emerges as funny, a bit wacky and very much a woman of the boomer generation, dealing with her mom and her daughter, her jobs and herself.
These days Fisher spends a lot of time writing."I didn't go into show business," she says. "The trick would have been to stay out."
And a bigger trick would have been to stay sane. Fisher writes openly about being bipolar and jokes about her image being used on a psychology textbook -- an image of her as Princess Leia.
"Obviously my family is so proud," she writes. "Keep in mind, though, I'm a PEZ dispenser, and I'm in the 'Abnormal Psychology' textbook. Who says you can't have it all?"


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Spending on California schools chief race expected to set records again
November 19, 2018 Jim Zellmer
Nico Savidge:
Spending in the campaign for state superintendent of public instruction in California is expected to break records once again this fall, as charter school advocates and labor organizations focus on the race.
Although the Nov. 6 ballot will include races for governor and U.S. Senate, it is the nonpartisan contest between Democrats — Assemblyman Tony Thurmond, D-Richmond and Marshall Tuck, a former charter school executive — for an office with limited power that is expected to attract the most money during the general election.
With seven weeks to go before Election Day, fundraising for Tuck has already surpassed what his supporters raised in the former school administrator's unsuccessful run for superintendent four years ago.
"This is going to be the most expensive election, period," said Sherry Bebitch Jeffe, a professor at the University of Southern California's Sol Price School of Public Policy.
Previous PostWhat happens to police departments that collect more fines? They solve fewer crimes.Next PostWho made key mistakes in Parkland school shooting? Nine months later, no one held accountable


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LA SPERIMENTAZIONE ANIMALE DALL' ANTICHITÀ AL DICIANNOVESIMO SECOLO (THE ANIMAL EXPERIMENTATION FROM ANTIQUITY TO THE NINETEENTH CENTURY)
Animal experimentation has played a key role in biomedical research throughout history, but it has also been a cause of heated public, scientific and philosophical debate for hundreds of years. The use of animals as models for study of human anatomy and physiology began in ancient Greece and reemerged in the Renaissance, to satisfy scientific enquiry. This technique laid the foundations of scientific medical revolution in the following centuries. Animal experimentation has now developed to the point that animal models are employed in all fields of biomedical research including, but not limited to, molecular biology, immunology and infectious disease, pharmacology, oncology, transplantology and animal behavior. This article reviews the use of animals in biomedical research from a historical viewpoint, with a look at the ethical controversy.
Titolo: LA SPERIMENTAZIONE ANIMALE DALL' ANTICHITÀ AL DICIANNOVESIMO SECOLO (THE ANIMAL EXPERIMENTATION FROM ANTIQUITY TO THE NINETEENTH CENTURY)
MONTINARI, Maria Rosa (Corresponding)
MEDICINA NEI SECOLI
Abstract: Animal experimentation has played a key role in biomedical research throughout history, but it has also been a cause of heated public, scientific and philosophical debate for hundreds of years. The use of animals as models for study of human anatomy and physiology began in ancient Greece and reemerged in the Renaissance, to satisfy scientific enquiry. This technique laid the foundations of scientific medical revolution in the following centuries. Animal experimentation has now developed to the point that animal models are employed in all fields of biomedical research including, but not limited to, molecular biology, immunology and infectious disease, pharmacology, oncology, transplantology and animal behavior. This article reviews the use of animals in biomedical research from a historical viewpoint, with a look at the ethical controversy.


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Home > Course > B.Tech Food (Bachelor Degree)
B. Tech (Food) is based on annual examination system and it is a four-year course with total of 2000 marks.
First year courses comprise of basic sciences, engineering, and microbiology. Food science courses and other courses fundamental to food processing are taught in the second year. Third and fourth years are devoted to teaching product technology, quality control, and food plant management. Besides, dissertation is compulsory.
An academic year consists of 150 working days. One theory paper of 100 marks will have 4 lectures per week. A lecture has duration of 50 minutes. One practical of 25 marks will have 4 hours of practical per week. 70 percent attendance in the class is compulsory for students.
Students will have to present a seminar on relevant topics in the fourth year. They also go to in-plant training for 45 days. Students are given orientation before they leave for the training. A total of 50 marks is allotted for seminar, in-plant training report and confidential marking obtained from the industry providing training for the student.
The procedure for deciding on the dissertation is quite involved. At first, an orientation program is organized to discuss on how to select a dissertation topic, write the research proposal, review of literature and write references. The students, then, with some assistance from prospective guides, submit a prioritized list of three possible topics of their interest. The Departments of Food Technology and Food quality control jointly deliberate on several aspects of the topics, mainly feasibility, significance and the appropriateness, before reaching the final decision. Students are notified of the decision and appropriate guides are allocated for the same. The total duration allocated for the dissertation work is six months with two months of full laboratory work. Usually the review work goes along with regular classes. The Department, later, publishes the dates of submission of draft and the final manuscript. After the completion of all thesethe defense program starts.
The details of the subjects and weightage for each are given below:
Subject full marks
Basic & Food Microbiology (T+P) 100 (75+25)
Physics (T+P) 100 (75+25)
Chemistry ( T+P) 100 (75+25)
Math and stats (T+P) 100 (75+25)
instrumental Techniques of Analysis (T+P) 100 (75+25)
Basic Principles of Engineering ( T+P) 50 (37.5+12.5)
Food Engineering (T+P) 100 (75+25)
Food Chemistry(T+P) 100 (75+25)
TFP-I* (T+P) 100 (75+25)
Biochemistry& Human Nutrition ( T+P) 100 (37.5+37.5+25)
Principles of Food Processing (T+P) 100 (75+25)
TFP-1*= Technology of Food products-1 (cereals, legumes, oilseeds and protein foods)
Biochemical Engineering (T+P) 100 (75+25)
Industrial Microbiology (T+P) 100 (75+25)
TFP-II ** (T+P) 100 (75+25)
Food Quality Control and Analysis (T+P) 100 (75+25)
TFP-III *** (T+P) 100 (75+25)
TFP-II**= Technology of Food Products-II (fruits and vegetables, chocolate and sugar confectionery, tea, coffee and spices)
TFP-III***= Technology of Food Products –III (meat, fish and poultry)
TFP-IV****(T+P) 100(75+25)
Storage and packaging(T+P) 100(37.5+37.5+25)
OR and FPM (T+P) 100(75+25)
Dissertation(T+P) 50
In-plant Training and class seminar 100(75+25)


The variety and magnitude of green tea health benefits are stunning. Find out what makes green tea so amazing for health and learn how you can optimize green tea's health benefits yourself.
To obtain the health benefits of green tea you can either drink at least 3 cups of green tea per day or take a supplement that contains green tea extract.
Green tea health benefits have been known for thousands of years, at least since 1211 when the Japanese Zen priest, Yeisai, published the book Tea and Health Promotion, in which he described green tea's medicinal effects. Discovered in China about 5,000 years ago, green tea was then brought to Japan from China by Buddhist priests. Today, scientific evidence indicates that green tea is indeed beneficial to health. In fact, there has been an explosion of green tea research around the world, and scientists are continuing to discover new health benefits of green tea on a regular basis.
What Is Green Tea and Why Is It Special?
Green tea, black tea, and oolong tea all come from the leaves of the Camellia sinensis plant, but green tea provides the most significant health benefits.
The difference between the three teas is in how they are processed during manufacturing. To make green tea, freshly harvested leaves are immediately steamed to stabilize the tea, preventing fermentation and the breakdown of the color pigments. The fresh steamed leaves then maintain their green color as they are rolled and dried.
Not only do these processes keep the tea leaves green, they preserve green tea's polyphenols (natural chemicals with health-promoting properties) and especially its catechins. Green tea catechins are transformed into different phytochemicals (with different biological activities) when tea leaves are fermented to oolong and then to black tea.
The health promoting effects of green tea are mainly attributed to its catechins. Catechins are a subcategory of flavonoids, which are a subcategory of polyphenols.
There are four catechins in green tea—epicatechin, epigallocatechin, epicatechin-3-gallate, and epigallocatechin gallate (EGCG). Of these four, EGCG is especially abundant, potent, and beneficial to health. EGCG has been found to influence how different genes get expressed and to have potent anti-inflammatory, anti-cancer, and antioxidant effects.
To obtain the health benefits of green tea, you can drink at least three cups of per day or take a supplement that contains green tea extract.
Some supplements contain green tea powder, which is not an extract and is unlikely to have much effect unless you take very large doses. Instead, look for an extract that concentrates the catechins. Pure EGCG is available in addition to various green tea extracts that contain a standardized amount of EGCG along with other green tea catechins. However, some researchers believe it is best to take a green tea extract rather than pure EGCG since pure EGCG is known to be an unstable compound and because the other components found in the green tea likely add to its therapeutic effect.
At this time, it is unknown as to whether there is a specific type, brand, or dose of green tea extract that's best But based on available evidence, a green tea extract standardized to between 80 to 90 percent total catechins or to between 40 to 50 percent EGCG is recommended at a total daily dose of 400 to 800mg.
With all these amazing health benefits of green tea, you would think the whole world would drink nothing else. But that is not the case. Many people just can't seem to work it into their schedules. And certainly the sugar loaded variety of green tea found in bottled teas can do as much harm as good with all that extra sugar. So what do you do? Have you found a way to enjoy green tea, or is there a variety or brand that you especially enjoy? Please share your experience with other readers so we can encourage each other to better health!
 ProcJpnAcadSer B PhysBiol Sci. 2012 March 9; 88(3): 88–101.
 Chin Med. 2010; 5: 13.
 Int J Womens Health. 2013; 5: 477–486.
 Nutr J. 2013 Jun 18;12:84.
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I love green tea and find its taste very refreshing and satisfying. I make a freshly brewed pot of green tea in the morning and then pour that over ice throughout the day. For me, it works as a great energizer without the sugar spike that sodas deliver. My morning brew of tea comes from two different green teas – one teabag of Madura Green Tea and Papaya Leaf (http://www.maduratea.com.au/) and one tea ball filled about 1/3rd with the China Gunpowder organic green tea which comes from http://www.teafountain.com. There are many other varieties available, but I've found this combination gives me the wonderful flavor that causes me to want to drink it every day. And these health benefits are a great bonus.
This is a great idea, Tom. I'm going to try it and pass the idea along to others. Thanks!
I love green tea. It is loaded with plenty of health benefits. It possesses several nutrients and some active molecules that shows excellent pharmacological significance. I have gone through an article entitled " 10 Benefits of Green Tea That Everyone Should Know" at zovon.


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Send a Kid to Camp Program
Mental & Behavioral Health
Regent Healthcare
Dresses4Dreams
HomeFamily Matters: DreamMakers, Unapologetically Investing in the Underserved
Family Matters: DreamMakers, Unapologetically Investing in the Underserved
Original Source: Huffington Post
I believe we can change the world. My passion is seeking out and shining a light on people, businesses, organizations and communities that are doing just that. I call these people DreamMakers. Family Matters of Greater Washington led by their visionary President and CEO, Tonya Jackson Smallwood are DreamMakers.
Joe Brodecki, the DreamMaker who led the Campaign to Remember fundraising initiative for the development of the United States Holocaust Memorial Museum introduced me to Tonya.
"I have an idea for another Huffington Post piece on a wonderful, remarkable woman, her name is Tonya Jackson Smallwood. Tonya leads Family Matters, which serves people from the womb to the rocking chair. Tonya is one of the most inspiring people I've ever met—she is a true DreamMaker. Interestingly, she commutes by bus to DC from Spotsylvania everyday; talk about commitment".
Three weeks later I was in Tonya's office in Washington, DC learning about Family Matters and the impressive, and indeed inspiring, woman that leads this exceptional social enterprise. And yes, Tonya does commute by bus, some days taking three hours each way, to help serve the underserved. It is my privilege to shine a light on Family Matters and Tonya Jackson Smallwood.
While the media is consumed with the violence and protest in our country and around the world, it is also important to focus on the root causes of most crime and unrest—poverty, lack of education and hopelessness. History has taught us again and again, that when people do not feel valued, seen or heard for generations, inevitably that hurt turns into anger. Penned up anger is like a pressure cooker, if it does not find release, it inevitably explodes.
Family Matters understands this. This iconic organization has been a release valve for thousands of underserved families in the greater DC community for 133 years. They not only assist the disadvantaged with basic needs to relieve the intense pressure that poverty weighs on people, families and communities, they also have the insight and foresight to invest in the development of people to enable them to help themselves. While many in our country have bought into the myth that investing in the youth, the poor, the elderly and the disenfranchised is counterproductive, Family Matters understands that the only way to stop the insidious cycle of poverty and the ills it produces is to invest in people. For the last six years, Family Matters has been led by a CEO who served 19 years in corporate America and feels it is a privilege to serve the most vulnerable of our society.
Tonya joined Family Matters in 2009 when the organization was experiencing turbulent times that were exacerbated by the nation's deep recession. She has inspired the Family Matters team and partners to dare to dream big. Tonya not only steadied the organization, she and her team are transforming this non-profit organization into a flourishing social enterprise.
"From day one, I have believed in the importance of identifying and applying compassionate solutions to big, seemingly intractable social challenges. To me, applying compassionate solutions means approaching people as individuals, not clients and addressing their challenges without judgment, but rather with a sense of dignity, compassion and purpose, knowing solutions do exist. At Family Matters I have fostered a culture of purposeful experimentations to find new and creative ways to do exactly that".
"The non-profit sector is a far more complex social ecosystem than many give it credit for. There are not only huge fiscal challenges in serving a community where need greatly exceeds existing resources, there are social, political, and pedagogical obstacles standing in the way of a better tomorrow. But I am a big thinker, and the big picture for me is about finding a way around each and every challenge that I face. I am not doing this alone: I am continuously building a strong cohesive team of game-changers who share my passion and belief in a better tomorrow through the actions of our work at Family Matters today".
Tonya has a proven track record of leading with vision and values, building innovative programs and engaging and energizing employees and partners to deliver superior results. Her personal story helps us to understand how she continuously achieves the seemingly impossible and gives us insight into why synchronicity loves to dance with her spirit.
Tonya's leadership philosophy is born out of her unapologetic belief that "With God all things are possible". Guided by her faith she has achieved remarkable success as a senior corporate executive, an entrepreneur and as a philanthropist. Tonya lives her faith. She does not compartmentalize her belief system.
"My personal mission is to help people achieve their highest potential and live their best life. It's about exposing people to a higher level of thinking, which then translates into a higher level of being, which translates into a higher level of living! The best of life is available if you know how to tap into it. I believe that anything is possible and what limits the vast majority of people in the world is that they don't know that."
Tonya believes in miracles. Her life has been a series of miracles and she has overcome tremendous obstacles. She conquered the challenges that come with teenage pregnancy and being a single mom determined to live her best life and provide an even better life for her son. Tonya graduated with honors from Purdue University and shortly afterwards obtained her master's degree from George Mason University. She later rose to become a successful vice president at Freddie Mac, managing 300 billion dollars of mortgage commitments & purchases. Shortly after leaving her lucrative corporate position, her husband became ill and she became his primary care giver. When he recovered she took that opportunity to pursue a long held dream. Tonya started her faith-based nonprofit foundation, Experience Imagine, to help people to see that anything is possible.
In the midst of pursuing her dream the great recession happened. When the 2008 financial market crashed it greatly impacted Tonya's plans and caused her to slow efforts to advance her dream.
In 2009, Tonya received a call out of the blue recruiting her to lead Family Matters. She was unsure whether this was the right path for her however, relying on her faith, she decided to explore the opportunity. Soon after taking the job she realized that the marriage between Family Matter's proud legacy, her corporate experience and her personal vision, could be leveraged to do amazing things, and she was right. Under Tonya's leadership, the Family Matters team has achieved impressive results. They are serving more than 22,000 seniors, families, teens and youth in Greater Washington through an array of innovative and empowering programs including: Aging and Disability programs for seniors, Technology Training, Bright Futures Teen Mothers Program, Mental Health Services, Foster Care and Adoption, and Youth Development programs. They are not satisfied with just serving those in need, they are committed to making dreams happen for families, children, teens, adults and seniors, most of whom are struggling to survive on less than $20,000 a year.
This summer will be Family Matters 49th year for their Camp Moss Hollow Youth Development Program. Through their summer and winter camp they bring the arts; dance, drama, music to more than 1000 youth annually, along with outdoor activities and organized sports. They also offer innovative academic improvement program such as their new partnership with NASA Goddard Space Flight Center's Summer Innovation Program that offers Science, Technology, Engineering and Math. These programs and activities are potentially life-changing experiences for young people who are living in environments that are underserved and underexposed to life-building opportunities that many of us take for granted.
One highly innovative program offered by Family Matters is the Ways To Work program. They provide low interest car loans to "economically and credit-challenged families" to enable them to get to work, repair their credit standing and to improve their financial literacy. In 2013, this program earned Family Matters the "Premier Program Performance Award" presented by Wal-Mart.
The most significant recognition of Family Matters committed service to the community came in 2013 when Family Matters received a gift of $28 Million dollars from the estate of philanthropist Richard A. Herman, a long time supporter of Family Matters.
"This gift will help fund an innovative collaboration with John F. Kennedy Center for the Performing Arts and Family Matters to bring arts programming to low-income District seniors and youth. The goal of the program will be to educate and expose District youth and seniors to various art forms, as well as introduce the healing power of the arts to those in need. The power of the arts to transform lives is well-known, and we hope to spark the interest and creativity of both young people and seniors whose access to the arts has been limited, due to their circumstances and income."
Family Matters is not resting on their laurels, they are poised to grow and flourish. Last year Tonya led the organization through a shared visioning process that resulted in a new and compelling mission; a bold and ambitious vision, and shared values to help them navigate the next chapter of their Journey:
Tonya's personal vision for Family Matters is big, bold and uncompromising. She sees Family Matters as a household name and the impact of their work influencing communities around the world.
"Family Matters is made up of some of the most compassionate, intelligent, hard working men and women whom I have had the privilege of leading, and I see many ways, each day, how we are making our local community, and our greater society, a better, more equitable place for all. We can only continue to do so with the support of our communities getting involved, because we know in this society everyone matters."
On my quest to spotlight DreamMakers, I continue to be amazed at the number of people around the world who are committed to creating a world where people and the planet can flourish. Every DreamMaker that I have had the privilege of interviewing see the world in the same awe-inspiring light. They have a sense of responsibility beyond their own lives. They take responsibility for the world we live in and are committed to making it better. They share a characteristic I call practical-optimism, although they clearly perceive current reality, and unflinchingly confront it; they share a deep faith that any challenge can be overcome. Their visions are large, deep and unaffected by cynicism. Tonya Jackson Smallwood and Family Matters are what my mentor Max De Pree, former CEO and Chairman of Herman Miller calls, "a gift to the human spirit."
Family Matters of Greater Washington 425 I St, NW, #700 Washington, D.C. 20001
Compassionate Solution Centers
Careers | info@familymattersdc.org
© 2016 Family Matters of Greater Washington.


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Skip Navigation LinksHome > Platforms > 2005-2011 > PS3 > Boarding
PlayStation 3 Boarding and Surfing Games
Shaun White Skateboarding
Shaun White Skateboarding, a game that puts an innovative twist on the action-sports genre, is the latest offering in the award-winning franchise developed in collaboration with dual-sport super-athlete, Shaun White. More...
Shaun White Snowboarding
Enter a snowboarding world of total freedom. You can create your own experience in this game, and choose when, where, how, and with whom you want to ride. Developed in close collaboration with Olympic Gold Medalist Shaun White. More...
Skate is the closest thing to skateboarding without actually putting your feet on a board. Skate delivers the feel of skating through innovative controls, authentic cameras and a fully reactive skateboarding city. More...
Skate 2 brings gamers to New San Vanelona, a city that's been rebuilt after an unspeakable disaster five years ago. Equipped with double the bag of tricks, players are tasked to rebuild their career and revive the skate scene. More...
Team Up. Thrown Down. The award-winning SKATE franchise returns to break new ground with SKATE 3. Delivering the definitive co-op skateboarding experience, it's up to players to build the ultimate team and change the face of the city. More...
Tony Hawks Proving Ground
Tony Hawk's Proving Ground, set in the streets of Baltimore, Philadelphia and Washington, D.C., empowers players with the freedom to define their character, story and style based on the choices they make, the paths they select and the style of skating they want. More...


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Governors' Wind Energy Coalition
Letters & Presentations
June 19, 2015 Presentations
Home » News » Amid climate change concern, GM rolls out big new Chevy SUVs
Amid climate change concern, GM rolls out big new Chevy SUVs
Source: By Tom Krisher, Associated Press • Posted: Thursday, December 12, 2019
Global concerns about climate change are not stopping General Motors Co. from making large SUVs for U.S. drivers.
GM on Tuesday rolled out the next generation of its big truck-based SUVs with more space and features. They're also heavier with only a small improvement in gas mileage.
The 2021 Chevrolet Tahoe and Suburban will come out in the middle of next year. They'll be longer and weigh more, because customer research showed a need for more interior space.
"People wanted a greater ability to haul families and their cargo, so that was the baseline that set our decisionmaking process," said Dwight Schoenefeld, lead development engineer on the SUVs.
But Dan Becker, director of the Safe Climate Campaign, a Washington environmental group, said GM and other automakers spend billions on advertising to convince people to buy the thirsty and highly profitable trucks and SUVs.
"GM claims that they are merely meeting consumer demand for gigantic vehicles, but most consumers don't use their pickups and SUVs for lumber and machinery but to haul lattes home from Starbucks," he said.
The length of the Tahoe will grow nearly 7 inches to almost 211 inches. The Suburban gains just over an inch in length to nearly 226 inches. The extra length, though, enabled engineers to raise the Tahoe's cargo space behind the third row by 67% to 25.5 cubic feet. Suburban rear cargo space rose about 5% to 41 cubic feet.
The Suburban and Tahoe also get a raft of new features including standard automatic emergency braking and a 10-inch touch screen.
All of the features will add 50 to 200 pounds, depending on options, to the SUVs.
Yet even with the additions, mileage will get "incrementally" better, Schoenefeld said. GM said it doesn't have government-certified mileage numbers yet. All versions will have 10-speed automatic transmissions, more efficient than the current six-speed gearboxes. GM will offer a 355-horsepower, 5.3-liter V8; a 420-horsepower, 6.2-liter V8; or a more efficient 277-horsepower, six-cylinder, 3-liter diesel engine.
The new SUVs, unveiled Tuesday night at an arena in Detroit, also will get stop-start technology that shuts off the engine at stop lights, and the engines will be able to run on as few as two cylinders to save fuel.
Currently, the GM SUVs are among the least-efficient new passenger vehicles on the road, and the mileage hasn't improved much in the past decade. For instance, a two-wheel-drive Tahoe in 2010 with a 5.3-liter V8 engine and six-speed transmission got 15 mpg in the city and 21 on the highway, according to the fueleconomy.gov website. The 2020 version of a two-wheel-drive Tahoe with the same engine and transmission got the same city mileage but improved by 1 mpg on the highway.
Edmunds.com analyst Jessica Caldwell said climate change may be a concern for some buyers of truck-based SUVs, but it's not the biggest factor. Most big SUV buyers, she said, need space and towing capacity.
"As long as fuel prices remain relatively low, buyers are less likely to go out of their way to seek alternatives," she said.
U.S. government fuel economy standards haven't forced mileage of truck-based SUVs to improve very much, said John German, a senior fellow with the International Council on Clean Transportation. Big trucks only have to improve about 1.5% per year from 2017 through 2021, versus about 4% for cars, he said.
A 'Nerve Center' for Climate in the Biden White House
'Existential threat': Yellen wants a climate hub at Treasury
Climate fight may split justices along ideological lines
Biden picks DOE chief of staff
©2021 Governors' Wind Energy Coalition. All Rights Reserved.


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Mr Kiragu at his hatchery.
It takes a 15-minute drive from Naivasha Town to reach this highly guarded farm with a conspicuous 'Mbwa Kali' sign at the main gate.
In an area best known for flower farming, this state-of-the-art chicken hatchery comes as a pleasant surprise. Located on a seven-acre farm in the Karati area is a multimillion-shilling poultry investment by veterinarian Tony Kiragu. Nature Kuku Farm specialises in hatching Kalro Kienyenji chicks. The articulate and amiable farmer returned from the United States to set up the hatchery.
He had worked on a poultry farm in America for seven years, having won a Green Card but decided to return to his motherland. "I could no longer contain the urge to come back and follow my dream," he says.
On his return in 2015, the Kenya Agricultural and Livestock Research Organisation (Kalro) had released improved kienyeji chickens, which had become quite popular.
SIMILAR STORY Hi am about to go into labour... Suzie your cow.
"I had sniffed a business opportunity and went for it," he recalls. Despite a few hiccups, Nature Kuku was born and sealed with the shipment of the multimillion shilling equipment to the farm.
"Once you vaccinate indigenous chickens and maintain proper hygiene, they do quite well," he says. Improved kienyeji chickens produce up to 280 eggs annually compared to pure breeds that lay on average 150 eggs.
The improved cockerel weighs about two-2.5kg at four months while the exotic ones weigh about 1.5kg. The farmer purchases 33,000 eggs from Kalro weekly. He decided to partner with Kalro because of its high quality and wellresearched breeding system.
Today, Mr Kiragu guarantees a farmer of an F1 chick, meaning that no inbreeding has occurred, thus maintaining a high quality of chicks.
Everything is done with precision from the time eggs are received to the time the chicks are finally loaded for transportation to farmers. Employees in yellow and white gumboots move fleetingly through the different rooms in the hatchery and in the chicken pens.
GET THE FULL STORY IN ISSUE 37 OF SMART FARMER MAGAZINE.


Tech Leaders call Donald Trump "a Disaster for Innovation".
His Imperial Majesty Ooni Adeyeye Enitan Ogunwusi (Ojaja II), the Ooni of Ife on Tuesday July 12 at his Ile Oodua Palace, signed a Memorandum of Understanding (MoU) with a U.S. based company SpringPort Technological Group. This MoU is to build a Technology, Media City and Agriculture incubation hub in the town of Osun.
This MoU will help the agricultural & technological incubation hub worth $1.4bn in its first phase, to fascilitate massive employment of Ile-Ife youths. The startup phase for the master plan was to begin with investors in London and Asia.
While signing the MoU, the Ooni urged Nigerians in the Diaspora to come invest in their country. And he also ensured that this project wasn't going to be a successful one.
"The initiative is an encouraging one and I urge the team not to relent. When I visited the USA, I met with our Diasporan people and told them that people built USA, it did not just develop. Just like the USA citizens built America, I am glad that some Nigerians in the diaspora are also keen to the development of their mother land.
I am totally in support of the project. I have never started a project without completing it and I hope this will be completed within the stipulated time. We don't want this to be a typical project that will start and won't end and because of that we need to sign the MoU today. We will also be fulfilling a larger part of what is expected of us by making available the required land," he said.
"The project will deliver a modern and progressive Ile-Ife with a strong real estate, technology and infrastructure backbone. It will deliver a master planned community that will allow residents to increase their productivity.
With this incubation Hub the level of employment of Ile-Ife youths as soon as they leave school, will increase.


Donald Trump said this week that he was "strongly considering" pardoning Joe Arpaio. The controversial former sheriff of Arizona's Maricopa County gained national attention for his aggressive stance on illegal immigration. A federal court convicted him last month for misdemeanor contempt of court for continuing to order his deputies to arrest suspected undocumented immigrants after a 2011 federal injunction that followed allegations of racial profiling.
Arpaio was an early endorser of Trump presidential campaign. The president has suggested that he will pardon Arpaio before an Oct. 5 sentencing date. Arpaio faces up to six months in federal prison.


Coming back to work after Christmas break can get even the best of us feeling the back-to-work blues. That meh feeling, being highly distractible, irritable, unable to concentrate, as we fall back into our normal routines.
Here are some ways to help kick the back-to-work blues into touch.
Continue those holiday activities like BBQ's after work, swims at the beach, drinks with friends etc.
Start the year off well and remember to take your breaks. First of all, it's always important to take breaks. In the change back to your work routine you may find that you have difficulty concentrating or have low energy. Remove yourself from your workstation, have a lunch date or take a brisk walk.
Tidy up your desk, workbench, shelves, files etc. in preparation for the year ahead. As a result, you'll feel organised and in control.
If you find yourself losing concentration and energy at the end of the day, it's probably better to leave those less mentally taxing jobs until then. Like tidying your workspace above!
You've most likely been more active over the holidays so keep it up! Exercise makes us feel better and when you feel good, you are more likely to work better.
Having something nice to look forward to can help in the transition back to work and keep that holiday feeling alive! So plan that next break!
Feel like your back to work blues maybe something more?


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SINGAPORE - The police are appealing for eyewitnesses for a fatal traffic accident that happened on Sunday morning.
A 33-year-old motorcycle rider was killed in the accident along Bukit Timah Road near Balmoral Road on early Sunday morning.
The rider, whose identity was not released by the police, was believed to have lost control of his motorcycle. No other vehicle was involved in the accident.
The police said that it received a call about the accident at 7.20am.
A police spokesman told The Straits Times: "The male motorcyclist was pronounced dead by paramedics at the scene."
Eyewitnesses can call the Traffic Police hotline on 6547-0000 .


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BBC Engineer Commits Suicide By Drinking Massive Quantities of Alcohol and E-Liquid
Coroner reports have declared the death of Jonathan Keen a suicide. The 46-year-old BBC engineer apparently died after binging on alcohol and ecigarette liquid. His girlfriend drove to his apartment when she couldn't reach Keen for more than 24 hours. When she arrived, she found Keen on the floor surrounded by cans and remnants of the eliquid he had ingested. When officials arrived on the scene, they declared Keen to be deceased. Investigators found a suicide note on a table near his body.
Relatives described Keen as a functioning alcoholic, but most of his colleagues were shocked at the news of his suicide. As a broadcast systems engineer, Keen reportedly loved his job and was well known as a reliable and honest professional.
Coroner reports from Richard Hulett revealed that Keen died from high levels of alcohol and massive quantities of ingested nicotine. Hulett noted that this was the first time he had ever encountered a suicide related to e-cigarettes in Buckinghamshire.
Keen's brother was quick to point the finger at ecigarettes as the cause of his brother's death, calling for tighter regulations and more safety measures. "What my brother did was very unusual. He used to manufacture his own liquids himself… He was clever so he knew how toxic it was. The fact that my brother should use it this way shows it is a deadly poison and needs to be controlled."
But officials in Britain have largely promoted ecigarettes as a healthier alternative to tobacco use. Hulett said the suicide note made it clear that this was not an accidental overdose. "We have a note here that talks about being sorry and talking about who gets what. That is the sort of thing people write at a very late stage," he said. "For whatever reason, his frame of mind that night became very negative. He was intoxicated and seemed to be cross about things… Looking at his notes and the toxicology, he got into a frame of mind where he decided to do this. What he was feeling was quite negative."
Over the course of history, people have used many substances to commit suicide, but this is the first time we have seen someone choose to opt out of life by drinking eliquids. It's a tragedy on many levels and we send our condolences to the family of Jonathan Keen during their time of loss.
Electronic Cigarettes • April 5, 2017
Smoko E-Cigarette Full Review | Reviewed by Vapers
No More Public Ecigs in Ontario Unless You're Vaping Marijuana


Rated 3.9 / 5 based on 411 reviews.
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Since the new Tool album is expected to be released in 2014, drummer Danny Carey at least announces himself with a musical sign of life - and what a sign! His quartet Volto! unites first-class musicians from L. A., who gave free rein to their love of seventies fusion à la Jeff Beck and Weather Report in a small jazz club. A CD recording was ultimately only a matter of time, and the fact that the nine tracks were recorded live undoubtedly underlines the qualities of the band around guitarist John "Volto" Ziegler, bassist Lance Morrison (Alanis Morissette) and keyboarder Jeff Babko (Larry Carlton). The title "Incitare" is to be understood literally, because Volto! is constantly driving itself to top performance. John Ziegler, who is completely unknown to us, is the discovery of this CD, as he sets the direction with juicy leads, lusty riffs and playful frills. Remarkable is also Danny Carey, who performs great drum grooves and knows how to inspire with his solos about ostinato figures. Volto bene!