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Pursuit of Honor
Mitch Rapp Series
Von: Vince Flynn
Gesprochen von: George Guidall
4,6 out of 5 stars 4,6 (44 Bewertungen)
The action begins six days after a series of explosions devastated Washington, D.C., targeting the National Counterterrorism Center and killing 185 people, including public officials and CIA employees. It was a bizarre act of extreme violence that called for extreme measures on the part of elite counterterrorism operative Mitch Rapp and his trusted team member, Mike Nash.
Now that the initial shock of the catastrophe is over, key Washington officials are up in arms over whether to make friends or foes of the agents who stepped between the enemy's bullets and countless American lives regardless of the legal consequences. Not for the first time, Rapp finds himself in the frustrating position of having to illustrate the realities of national security to politicians whose view from the sidelines is inevitably obstructed.
Meanwhile, three of the al Qaeda terrorists are still at large, and Rapp has been unofficially ordered to find them by any means necessary. No one knows the personal, physical, and emotional sacrifices required of the job better than Rapp. When he sees Nash cracking under the pressure of the mission and the memories of the horrors he witnessed during the terrorist attack, he makes a call he hopes will save his friend, assuage the naysayers on Capitol Hill, and get him one step closer to the enemy before it's too late.
Once again, Rapp proves himself to be a hero unafraid "to walk the fine line between the moral high ground and violence" (The Salt Lake Tribune) for our country's safety, for the sake of freedom, for the pursuit of honor.
©2009 Vince Flynn (P)2009 Simon & Schuster
Serie: Mitch Rapp, Titel 12
Kategorien: Literatur & Belletristik
Politik Spionage
"Flynn demonstrates that he truly understands the psyche of the enemy.... Really scary, so realistic." (BookReporter.com)
A Thriller
Spieldauer: 12 Std. und 9 Min.
Mitch Rapp and his protege, Mike Nash, may have met their match. The CIA has detected and intercepted two terrorist cells, but a third is feared to be on the loose. Led by a dangerous mastermind obsessed with becoming the leader of al-Qaeda, this determined and terrifying group is about to descend on America.
Hat nichtmehr den Biss wie in den alten Titeln
Von F. Roland Am hilfreichsten 26.11.2019
The four dead guards didn't concern Mitch Rapp as much as the absence of the man they'd been paid to protect. Joe Rickman wasn't just another foot soldier. For the last eight years Rickman had ran the CIA's clandestine operations in Afghanistan. It was a murky job that involved working with virtually every disreputable figure in the Islamic Republic. More than a quarter billion dollars in cash had passed through Rickman's hands during his tenure as the master of black ops and no one with a shred of sense wanted to know the details of how that money had been spent.
A Mitch Rapp Novel, Book 16
Von: Vince Flynn, Kyle Mills
Gesprochen von: Scott Brick
After 9/11, the United States made one of the most secretive and dangerous deals in its history. The evidence against the powerful Saudis who coordinated the attack would be buried. In return, King Faisal would promise to keep the oil flowing and deal with the conspirators in his midst. When the king's own nephew is discovered funding ISIS, the president suspects that the Saudis never intended to live up to their agreement.
Top-secret data has been stolen from the CIA, and the only man who knows its hiding place is dead. CIA operative Mitch Rapp must race to find the classified information in this blistering novel that picks up where The Last Man left off in Vince Flynn's New York Times best-selling series.
A nice dejavu, Mitch Rapp saves the world again
Von BikerJoe Am hilfreichsten 21.12.2015
The action begins in the heart of Iran, where billions of dollars are being spent on the development of a nuclear program. No longer willing to wait for the international community to stop its neighboring enemy, Israel launches a creative and daring operation that leaves a radioactive tomb in the middle of Iran's second largest city. An outraged Iranian government publicly blames both Israel and the United States and demands retribution.
Act of Treason
It's a gorgeous autumn day in Georgetown. The Democratic candidates for president and vice-president of the United States are dutifully glad-handing voters and the media outside a grand estate where a national-security conference has just been held, bringing together the world's greatest minds to discuss the issues that are threatening the country. It's American politicking at its best. That's when all hell breaks loose.
Order to Kill
Von: Kyle Mills, Vince Flynn
Mitch Rapp is used to winning. But in this follow-up to number-one New York Times best-selling The Survivor, the CIA operative finds himself chasing false leads from continent to continent in an effort to keep Pakistani nukes from falling into the hands of terrorists. Together with friend and colleague Scott Coleman, Rapp struggles to prevent the loss of these lethal weapons, particularly because Russia is also interested in the nukes, though not for the same reason as Rapp and Coleman.
Hard to listen to
Von Thomas D. Am hilfreichsten 31.08.2020
Consent to Kill
For years, Mitch Rapp's bold actions have saved the lives of countless Americans. His battles for peace and freedom have made him a hero to many, and an enemy to countless more. In the tangled, duplicitous world of espionage, there are those, even among America's allies, who want to see Mitch Rapp eliminated. They have decided the time has come.
Wow - super klasse
Von Frank Plawetzki Am hilfreichsten 29.05.2018
It's just seven days before Memorial Day, and a spike in CIA intelligence has pointed to a major terrorist attack on the United States. Now it's up to counterterrorism operative Mitch Rapp to pull out all the stops. Rapp immediately leaves for Afghanistan, where he leads a special forces unit on a daring commando raid across the border into a remote Pakistani village. Their target: an al-Qaeda stronghold. Rapp and his team soon discover plans for a catastrophic nuclear attack on Washington, DC.
Red War
When Max Krupin - Russia's leader - discovers that his kidney cancer has spread to his brain, he's determined to hide his diagnosis. He begins by getting rid of anyone threatening to him - as well as creating chaos in the region to keep the world's attention diverted. Soon, Krupin's illness becomes serious enough that he needs a more dramatic diversion, prompting him to invade the Baltics. Desperate to understand what's causing Krupin's unusually erratic behavior and Russia's aggressive moves in the region, America begins working with Russia's disgraced prime minister to stage a coup.
Lethal Agent
A toxic presidential election is underway in an America already badly weakened by internal divisions. While politicians focus entirely on maintaining their own power, ISIS kidnaps a brilliant French microbiologist and forces him to begin manufacturing anthrax. Slickly produced videos chronicling his progress and threatening an imminent attack are posted to the internet, intensifying the hysteria gripping the United States.
Returning from a covert mission, Mitch Rapp was publicly hailed by the president for his role in the fight against terrorism. After years of working in the shadows, Rapp was caught in the media spotlight - and marked for death by virtually every terrorist in the world. Now a CIA advisor, Rapp is ready to battle terror far from the front lines. But when a Navy SEAL team in the Philippines is ambushed, all evidence points to a leak within the U.S. State Department. And a greater threat lurks....
wieder so gut wie immer
Separation of Power
Gesprochen von: Ken Kliban
Newly appointed CIA director Dr. Irene Kennedy is the target of an inside plot to destroy her and prematurely end the American President's term. To make matters worse, Saddam Hussein is close to entering the nuclear arms race - something Israel has vowed to stop. With the haunting specter of World War III looming, the president calls on his secret weapon: top counter-terrorism operative Mitch Rapp. But with only two weeks to take out the nukes, Rapp is up against a ticking clock - and impossible odds.
komischer Band der Serie
Gesprochen von: Nick Sullivan
CIA counterterrorism operative Mitch Rapp falls prey to government forces with an agenda of their own after Dr. Irene Kennedy is named the successor to dying CIA Director Thomas Stansfield—a choice that enrages many inside the world's most powerful intelligence agency. Her detractors will resort to extreme measures to prevent her from taking the reins—which makes Rapp an expendable asset. But Mitch Rapp is no one's pawn, and he will stop at nothing to find out who has set him up.
Good mixture of action and scheming, but open end
Von Andreas B. Am hilfreichsten 27.03.2017
Mitch Rapp has worked for a number of presidents over his career, but Anthony Cook is unlike any he's encountered before. Cunning and autocratic, he feels no loyalty to America's institutions and is distrustful of the influence Rapp and CIA director Irene Kennedy have in Washington.
good but not awesome anymore
Von Philipp S Am hilfreichsten 07.10.2022
Oath of Loyalty
With President Anthony Cook convinced that Mitch Rapp poses a mortal threat to him, CIA Director Irene Kennedy is forced to construct a truce between the two men. The terms are simple: Rapp agrees to leave the country and stay in plain sight for as long as Cook controls the White House. In exchange, the administration agrees not to make any moves against him. This fragile détente holds until Cook's power-hungry security adviser convinces him that Rapp has no intention of honoring their agreement.
Mitch Rapp at his best!
Von Manfred Am hilfreichsten 04.01.2023
Transfer of Power
On a busy Washington morning, the stately calm of the White House is shattered in a deadly terrorist attack on the executive mansion. The president is evacuated to an underground bunker, but not before nearly one hundred hostages are taken. Mitch Rapp, the CIA's top counterterrorism operative, is sent in to take control of the crisis and determines that the president is not as safe as Washington's power elite had thought....
Thrilling from the first minute!
Von Ralph Am hilfreichsten 05.07.2018
When Mitch Rapp captures ISIS's top technology expert, he reveals that he was on his way to meet a man who claims to have the ability to bring down America's power grid. Rapp is determined to eliminate this shadowy figure, but the CIA's trap fails. The Agency is still trying to determine what went wrong when ISIS operatives help this cyber terrorist do what he said he could — plunge the country into darkness. With no concept of how this unprecedented act was accomplished, the task of getting the power back on could take months. Perhaps even years.
Consent to Kill—Der Feind: Thriller
American Assassin - Wie alles begann
The Dark Tower I: The Gunslinger
Das sagen andere Hörer zu Pursuit of Honor
Frank Plawetzki
Dachte nicht das die Serie noch besser werden könn
Die vorherigen Teile waren (bis auf eine Ausnahme meiner Meinung nach) alle sehr spannend und mitreißend.
Ich hätte niemals gedacht, dass der Author noch eine Schippe drauf legen kann.
Das Ende dieses Buches ist so spannend, dass ich schon gefürchtet habe, ich kriege einen Herzstillstand :)


So you have setup your own mail server on Digital Ocean. Everything works great, but for some reason all of your outgoing mail to Gmail's addresses ends up in the Spam folder. What to do?
SPF is a validation system to detect spoofing and needs to be setup in your DNS records. Fire up the DNS console of your droplet and make sure that you have it setup properly by adding a "TXT" record with the following content: "v=spf1 mx -all". This assumes you have a proper MX record setup already. Check the SPF syntax documentation here for more information.
Don't bother to setup DKIM, it doesn't seem to matter for the purpose of getting your mail delivered to Gmail.
If everything seems in place, but your e-mails are still being categorized as Spam, you might want to spawn a new droplet and get a new public ip for your mail server. Google seems to hold a private blacklist of IPs from which e-mails are automatically flagged as spam. Some of these IPs are used by Digital Ocean and there's nothing you can do to whitelist them. Your only option is to spawn another droplet, get assigned a new public IP, and try again.
Fortunately this process is painless. Simply take a snapshot of your current droplet, spawn a new one and choose to restore your snapshot. Then update your DNS records and try to send an e-mail from the new IP. I got lucky and the second droplet I spawned worked for me.


Welcome to our new website! As we begin to settle into things, we want to take a moment to share not only what Cache~Cachet has to offer, but also what we stand for as a business.
As a company, Cache~Cachet believes all your garments should be stored in a safe, natural environment. We offer 5 different garment bags and covers to accommodate all your clothing. From sweaters to gowns, we can guarantee your items will be safe for years to come.
Cache~Cachet holds the health of our earth close to our hearts. Our garment bags are all natural, eco-friendly and chemical free. Our sachets are filled with lavender, rosemary, wormwood, peppermint and black pepper. This herbal blend naturally keeps your garments moth free and smelling fresh.
Storing your garments in Cache~Cachet's protected environment will extend the life of your garment much longer than it would in traditional storage. This will not only make your wallet happy, you will also be helping to cut down on the pollution and waste from the production of fast fashion.


"I always take my Kindle Fire with me no matter where I go. It is such a convenient and compact tablet that I can read, listen to my favorite playlist, and watch videos as well whenever I want. However, Kindle Fire seems incompatible with PPT. This is baffling when I need to view some PowerPoint files on my Kindle Fire. I suppose there are solutions to solve this, right? ."
Though PPT is incompatible with Kindle Fire at the moment, it can be resolved by converting PPT to Kindle Fire compatible format. Find more details from the below article.
The Fire Tablet, formerly called the Kindle Fire, is a tablet computer developed by Amazon.com. It is built with Quanta computer, featuring a color 7-inch multi-touch display with IPS technology and running a custom version of Google's Android operating system called Fire OS. In total, it provides 8 GB internal storage in the first-generation Kindle Fire, approximately 6.5 GB was available for contents. That is to say, you can store pretty much contents including text, books, music, and videos on your Kindle Fire. What Kindle Fire can do is far more than an e-book. But if you want to view PPT on Kindle Fire, you have to convert PPT to another format first.
From the Kindle Fire manual, we can learn that not all formats are supported by Kindle Fire; and yes, PPT is one of the not-supported formats. Check the below table for detailed supported formats by Kindle Fire.
As you can see, PPT series file extensions are not among the supported format category, and the good news is even though PPT cannot be open directly on Kindle Fire, we can still find a way around to let PPT viewable on Kindle Fire. Keep reading.
The first solution coming to your mind may probably be saving PPT as PDF within Microsoft office for Kindle Fire. You can simply ready your PowerPoint presentations and save the file in PDF format, then transfer the PDF to your Kindle Fire for reading. Steps to save as PDF is listed below.
Step 1: Open your PowerPoint. Get ready all contents.
Step 2: Save the file in PDF format. Click Save as from the File menu, pick Computer and click Browse on the right pane.
Step 3: Select PDF from the Save as type list.
Otherwise, you can refer to Kindle support for details. In this case, Kindle Fire can directly open the file and allow users to view them freely. Note that saving as PDF won't help keep the elements in a PPT file, such as transition, animation, music, and so on. Only text contents are kept so it is somehow not friendly.
To keep all elements in the PPT, we can consider to convert the PPT to a Kindle Fire compatible video format, Leawo PowerPoint to Video Pro is a good choice. It develops a series of user friendly features to help users to convert PPT with background music, logo, and the like. Files can be processed with this app effortlessly and the one-stop solution makes the file conversion experience remarkably enjoyable.
Step 1: Download Leawo PowerPoint to Video Pro.
Click the below button to install this app.
☉ Support all PPT formats: PPT, PPTX, PPTM, PPS, PPSX, POT, POTX, POTM.
☉ Adjust video and audio parameters of output files.
☉ Customize PowerPoint files like: insert background music/watermark, set transition, real-time narration.
Click Add to import files. I suggest you import files in batches and process at a time.
Step 3: Set an output format.
View the formats from the Profile drop-down list and pick one accordingly. Here we tap iPad.
Step 4: Make the file more powerful and attractive.
Click Customize to set the file parameters in details, such as set the video quality, audio codec, music, and others through the Customize settings pane.
Step 5: Protect the file with unique watermark.
Click Watermark to add a unique logo or trademark to protect your file. If done so, the file cannot be copied or edited randomly.
Step 6: Convert PPT to Kindle Fire compatible format.
Click Start to process the file. View the process through the green progress bar. After all is done, transfer your video to Kindle Fire using USB cable.
All in all, Amazon PowerPoint presentation is odd because Kindle Fire cannot open PPT natively. There are a variety of ways to solve this, among which saving PPT as PDF is the most direct way. The only problem for PDF is that it cannot keep PPT elements. To our joyfulness, Leawo PowerPoint to Video Pro can perfectly retain original elements in a PPT file. By the way, the customization features provided by this app also highlight the overall performance and ranking in the industry, making it very popular among global users. Do not hesitate to give it a shot.


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Based in San Francisco, The Open String is a non-profit organization that provides schools and musicians with access to quality string instruments. The unique venture ensures that both students and educators are able to succeed in the growing music education movement.
Traditionally trained as a luthier, Robert Brewer Young has been creating string instruments for over twenty years. While he has had various musicians play his hand-crafted pieces, Young was determined to establish a platform that would carry on his truly heart-warming work. With the help of Designer/ Director of Development, Lucien Jamey and Managing Director, Elfin Vogel, The Open String was founded in 2014.
With a focus on helping those in disadvantaged communities, The Open String hosts various programs throughout the year. The String Drive program is run to collect and redistribute strings and supplies through donations made by the wider public, musicians etc, whereas the Annual Grant Program raises funds to purchase new equipment for children, students and the like.
These programs aim to encourage children to focus their energy on a worthwhile and meaningful skill, rather than succumbing to the pressures and perils of their surroundings. They really are being given, the gift of music.
Another mission of the organisation is to assist promising musicians in being recognised and give them opportunities tp play for a live audience. By running annual events, The Open String allows these students to do so, while gaining an excellent opportunity to promote what they stand for and ask others to join them.
The Open Strings Annual Grant Performance is on December 8. For more information visit SFCV or to donate, visit The Open Strings Website.


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ACCELERATING INNOVATION
Texas A&M College of Engineering Twitter hashtag #NewZachry Instagram hashtag #NewZachry College of Engineering Facebook College of Engineering LinkedIn
Texas A&M Engineer
engineering research magazine special edition
The Bush Combat Development Complex recently hosted events demonstrating Texas A&M System researchers' advancements in land and air autonomous vehicles. State and national government officials also continue to express their excitement and support for the BCDC and its role in helping the Army advance its goals of modernization.
You are here: Home / Special Issue 2020 / In the News
Trusted Capital Event: Drone Venture Day
The BCDC and the U.S. Department of Defense co-sponsored a Drone Venture Day (DVD) Nov. 13, 2019. This was the first in a series of Trusted Capital events. The intent of these events is to build a network where trusted capital providers and domestic companies can explore mutually beneficial business partnerships focused on national security requirements.
Autonomous Vehicle Demo Day
On Dec. 12, 2019, Texas A&M's autonomous vehicles and tactical networks research teams worked together to conduct the BCDC's first large demonstration. During the demo, two ground vehicles maneuvered autonomously through an off-road challenge course, and a Jeep and air vehicle operated autonomously by communicating with each other.
"Futures Command is looking to partner with any number of folks who can help us advance our modernization goals, and we think that Texas A&M offers us another opportunity to do that."
Mark T. Esper, Former U.S. Secretary of the Army and current U.S. Secretary of Defense
May 11, 2019 – Commissioning of 49 members of the Texas A&M Corps of Cadets into the Army
"There is a deep and enduring bond between the state of Texas the United States military. The opening of the Army Futures Command represents the next step in that partnership. With innovative technology companies, emerging startups, a rich pool of talent and world-class universities, Texas is the ideal choice to help launch the Army's most significant reorganization effort in more than four decades."
Texas Governor Greg Abbott
August 24, 2018 – Activation ceremony of the U.S. Army Futures Command in Austin, Texas
"Our country's military readiness depends on innovation, and the Army Futures Command is on the front line of that fight. This partnership with the Texas A&M University System will ensure we have the best and the brightest working to address rapidly evolving threats and maintain our strategic advantage around the world."
U.S. Senator John Cornyn, R-Texas
October 2, 2019 – Announcement of a five-year, $65 million agreement for the Texas A&M System-based tech research that will support the Army's efforts to modernize its fighting forces and capabilities
"This is a commitment. It's a commitment by the state of Texas … it's a commitment by Texas A&M and the Texas A&M University System and it's a commitment by the U.S. Army. And it's really all about what we believe at Army Futures Command — that America's tomorrow is worth protecting and it's worth starting that today, right here, right now."
Commanding General John "Mike" Murray, Army Futures Command
October 12, 2019 – Speech at the George H. W. Bush
Combat Development Complex groundbreaking at the RELLIS Campus
Texas A&M Engineering Experiment Station (TEES)
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An Update on Dry Age-Related Macular Degeneration and Geographic Atrophy (March 2021)
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Dr. David S. Liao
A board-certified ophthalmologist at the Retina-Vitreous Associates Medical Group
The event featured Dr. David S. Liao, a board-certified ophthalmologist at the Retina-Vitreous Associates Medical Group who specializes in the medical and surgical treatment of diseases of the retina and vitreous. Dr. Liao discussed the latest treatments to manage dry AMD and geographic atrophy, recent clinical trials, ways to slow the progression of vision loss, and how to maintain and improve quality of life after the diagnosis of a vision loss disease.
An Update on Dry Age-Related Macular Degeneration and Geographic Atrophy
1:00 p.m. EST
Please note: This Chat may have been edited for clarity and brevity.
MICHAEL BUCKLEY: Hello, I'm Michael Buckley with the BrightFocus Foundation, and welcome to today's BrightFocus Chat. Today we're going to have an opportunity to learn more about dry AMD and another form of macular degeneration called geographic atrophy. So, if this is your first time at a BrightFocus Chat, thanks so much for joining us. We're going to spend between 30 and 40 minutes hearing from one of the leading experts in age-related vision disease. We'll have a chance to ask some questions, and hopefully it's a very informative conversation for everybody. If you're new to BrightFocus, I want to tell you we fund scientific research all around the world to find better treatments and ultimately cures for macular degeneration, glaucoma, and Alzheimer's. We want to share the latest news and best practices with our audience, so that's why we created the BrightFocus Chats. So, today we are going to talk about dry AMD and geographic atrophy. We have an outstanding guest to help us with this. His name is Dr. David Liao. He is a leading ophthalmologist in Southern California. He was with us about a year ago, and we had a great conversation, so we really wanted to bring Dr. Liao back. So, Dr. Liao, I was wondering if you could just tell us a little bit about yourself, and how did you end up doing what you're doing for a living?
DR. DAVID LIAO: Sure, thanks, Michael. So, as you mentioned, I'm a retina specialist. I've been practicing out in the Southern California–Los Angeles area for about 10 years, and I think people always ask, "Why you did you go into ophthalmology or retina, in specific?" And I think as a medical student, you always go in trying to pick a field that you could help a lot of people, and I think ophthalmology just really stood out to me as something where you can—no pun intended—see results. And there was a lot you could do to improve people's quality of life, and when I was doing training, the retina was kind of exploding in our ability to treat diseases, like wet macular degeneration, and that really got me interested in retina, and it's really just continued to expand as time has going on. There are so many new treatments out there and treatments for diseases that we weren't even treating in medical school, like wet macular degeneration and—now, hopefully, in the future—forms of dry macular degeneration and geographic atrophy, also.
MICHAEL BUCKLEY: That's exactly what we want to talk about today. We invited Dr. Liao to tell us a little bit about how these … what these diseases are, how to manage them, and to give us an update on some really promising work that's being done in labs all around the world. BrightFocus supports a number of scientists that are working on these diseases. Again, there's not currently an approved treatment; it's just an incredibly important area. I was wondering, to get us started, Dr. Liao, could you tell us a little bit about what dry AMD and geographic atrophy are? In the family of age-related macular degeneration, what's what?
DR. DAVID LIAO: Sure. Yeah. There are two different types of broad categories of macular degeneration: There's the dry type, and there's a wet type. I think most people nowadays are familiar with the wet type, because that's the type where you get shots, and these injections have been around for a number of years—Avastin®, Lucentis®, Eylea®, and most recently, Beovu®. And with wet macular degeneration, this was the kind of disease that we used to see a lot of vision loss with because you get swelling in the retina, bleeding in the retina, and this causes sudden loss of vision—like a spot in the vision or distortion—will lead to a lot of scarring, and these medications target the abnormal blood vessels that are causing the bleeding, causing the swelling, and they actually help that to go away. And most of the time, people improve their vision after treatment and maintain it for many, many years.
Dry macular degeneration hasn't gotten as much press, perhaps, because there hasn't been a good treatment for it, but macular degeneration always starts out as the dry type first—that's the earlier or milder type—and what we usually see is people start getting the earlier forms of it. We see drusen and pigment hair changes in the retina, and these drusen are these fatty deposits—the yellow deposits—that can be seen when your eye doctor looks at the retina. Most of the times in the early and intermediate stages of the disease, you don't get many changes. You could see some distortion, some decrease in vision. Some people with dry macular degeneration go on to develop a more advanced type of dry macular degeneration. And this is what we're talking about when we're talking about geographic atrophy.
What happens is these areas of the retina start to thin, and the retina does work over those areas. The layers that are underneath the retina, like the RPE or the retinal pigment epithelium, start to thin, too, and these create blind spots—areas where you can't really see—that lead to difficulty reading. And, eventually, as these blind spots get bigger, these areas of atrophy get bigger; they could start to encompass the central part of your vision where your very high-definition vision is. And in those cases, the folks with that type of dry macular degeneration can get more severe loss of vision. And, unfortunately, at this point, there are no approved medications to treat that, although there are a lot of studies coming out that show that we could maybe slow this process down, and we can hopefully preserve vision for many years and avoid having this loss of the central vision—hopefully.
MICHAEL BUCKLEY: I appreciate you outlining the different forms. I think that central vision loss is going to be so hard, in terms of recognizing faces or reading or driving. So, when you look around at what's happening in research labs in the U.S. and throughout the world, are there things that make you hopeful?
DR. DAVID LIAO: Yeah, yeah, there are. I mean when I was in the medical school, I think people didn't really know the causes or the … there are multiple causes, but they really weren't familiar with all of these causes that play a part in the progression of macular degeneration. And many years ago, people—through epidemiology or genetic studies—they found genes that were associated with more advanced forms of macular degeneration, and when people have been looking at the laboratory of what goes on in the retina of people with macular degeneration, they've started to understand a lot more about the causes, and these have led to the development of the different medications that, hopefully, will prove to be beneficial in slowing down the disease.
MICHAEL BUCKLEY: Any particular companies or products in development that you feel hopeful about?
DR. DAVID LIAO: Sure, sure. So, yeah, as we mentioned earlier, there's this progression of dry macular degeneration, where you can get ongoing thinning of the retina. Before, we didn't know why, and one of the reasons that's becoming more evident now that this role in dry macular degeneration is the role of inflammation in the side of the eye. So, when you look at those fatty deposits that are found in the retina, you could see molecules that are involved in intraocular inflammation there. There's a system in our immune system, known as a complement system, and it's there for a good reason—it helps us to fight infections and kill off bacteria that shouldn't be in our body—but the molecules that have been involved in the complement cascade have been found to be localized in these drusen, and the thinking now is that ongoing inflammation in the macular is contributing to the thinning and then eventual atrophy of the retina. And a lot of these medications now are targeting the complement cascade, not so much to prevent our body from fighting infection but rather to stop the ongoing inflammation that's going on inside the eye, causing a slowing, if you will, of that process that's going on to stop the atrophy and to preserve, hopefully, central vision.
So, one of the companies that has had some good results in early clinical trials is Apellis—they're a company, I believe, out of Massachusetts—and they have a drug called APL-2 that blocks C3; that's one of the molecules that's necessary to activate this inflammation in the complement cascade. And they've shown in their initial trials that when this medication is injected into the eye—it's done just like the wet macular degeneration injections, it's done in the clinic on a monthly or every other monthly basis—but they've shown that they can actually slow down the progression of geographic atrophy by about 30 percent. Now, it's not going to necessarily improve vision, but if you think of the process that's going on here, you're getting these enlarging spots where the retina isn't working, you're getting more blind spots, more difficulty seeing with light, and that's impacting reading and so forth and, eventually, may actually affect the central vision—where, if you lose that, you lose the ability to drive and to recognize faces and so forth. So, if we can delay that process by 3, 5 years, we're giving folks a lot more useful vision during their lifetime. So, the trials for that are going on now—the phase 3 trials—and, hopefully, we'll expect the results sometime later this year or early next year. But results have been fairly good.
There are other companies that are looking at other medications that also inhibit complement and try to prevent this inflammatory cascade that's going on inside the eye. One is Iveric; they have a drug that's targeting a different molecule—C5—which also has been shown to have some good results in clinical trials. This also is done by an intravenous injection; the eye injections that are done in the clinic would be done in a monthly basis. There are other companies out there that are targeting different molecules in the complement cascade. There are some other companies, as well, that have earlier trials—Alexion, for example. They have plans for a trial of an inhibitor of another factor in the complement cascade. This drug, however, this is going to be oral, so this may have advantage over the injection because it's less invasive. But we don't have as much data on that one yet. For the molecular type of trials, there are a number of them going on, and hopefully, as the year progresses, there'll be more and more results, and they'll look forward to getting approval in the next few years, if the results hold.
MICHAEL BUCKLEY: Dr. Liao, those are some very encouraging signs in terms of the complement inhibitors. Are there other approaches, whether that's in cells or vitamins or any other approaches that you're seeing promise?
DR. DAVID LIAO: Yeah, yeah. This is definitely a multifaceted approach. One of the things that is getting a lot of the attention nowadays is stem cells, like a cell-based approach. Basically, in the end stages of this disease, you've lost a lot of cells, you've lost a lot of retina there, and so people have been looking at implanting stem cells underneath the retina to try to replace the cells that have been lost. These trials are earlier, but they certainly have the potential to … perhaps if we can replace the cells that have been lost, maybe even reverse some of the vision loss, that's the Holy Grail out there. Hopefully, we'll get some good results from the trials.
There's one company, Astellas. They have a cell line that's a human embryonic stem line to replace the RPE—the retina pigment epithelium cells—that are underneath the retina and helps support the health of the retina. Their initial trials they involved people with Stargardt disease, which is kind of a juvenile macular degeneration, if you will, and folks with geographic atrophy, as well, and what they did is they implanted some of these cells surgically underneath the retina. And the goal in the initial trials is mainly for safety—to make sure the technique is safe—but they did see in folks who had the treatment that there was an improvement in the pigmentation levels underneath the retina, showing that the cells actually went where they were suppose to go and survived and produced some pigment that may have been lacking before. The vision results, it wasn't really … it was more geared toward safety, but some of the patients did improve vision-wise, and a modest amount, but again, that wasn't the goal of the trial—a long-term goal, of course.
There are some other companies out there that are trying to do other things. Like, they have a patch, if you will, that's grown in the laboratory, and they're also trying to introduce that surgically underneath the retina to try to replace some of the retina pigment epithelium cells that were lost. So, a lot of companies out there are trying to do these things—in early stages, of course, but very promising. That's kind of on the replacement front.
There are also companies that are trying to kind of preserve the function, if you will. So, one of the other theories out there is that the metabolism—the byproducts of the metabolism—that the retina is very metabolically active; it uses vitamin A to basically provide vision. As the light hits these forms of vitamin A, they change their shape and allow us to perceive vision, and the byproducts of this product of the vitamin A are thought to be involved in causing toxicity to the retina over time. And so, there's a company called Alkeus that has a modified form of vitamin A out there that seeks to replace the natural form, if you will, of vitamin A, but the byproducts of this vitamin A are supposedly less toxic to the retina, so the thinking is that if that is used, then the toxicity to the retina will be less over time, and you can slow down the progression of macular degeneration or geographic atrophy over time. That medication may have some side effects. Of course, that's why they're doing the trials, but also very promising.
There other companies out there. There's one drug that's been used for glaucoma called brimonidine, and that lowers the eye pressure, but people also think that it helps preserve nerve cells in glaucoma and may help to preserve the neural-type tissue that's in the retina. So, they've actually been injecting a small, slow-release pellet of that medication into the eye, and they've also shown that it has some modest effects of slowing geographic atrophy, as well, so that's from a more neuroprotective standpoint, if you will. There are also folks out there that are looking at light or what's called photobiomodulation. Light has been used in other fields for years to try to help scar tissues, healing, and so forth—dermatology type of applications—but I believe one of the listeners submitted question about red light. So, there's a company out there called LumiThera that's using a device to expose the retina to low levels of a specific wavelength of light and infrared wavelength, and this has been shown as some of their primary … their initial studies to improve retinal functions, so they're doing larger trials to see, does that replicate in a number of patients, or does it help patients see better or detect light better in geographic atrophy? That's a whole other nonpharmacological approach, so very interesting ways of kind of attacking the disease, and it may turn out patients use more than one of these to get a synergistic effect on improving vision and delaying disease progression.
MICHAEL BUCKLEY: I really appreciate such a comprehensive look at, really, what seems like a really helpful scientific pipeline, and I appreciate your point that maybe, in the end, it could be one than more treatment for a person. When you mentioned different promising drugs, you frequently mentioned clinical trials, and I think in the last 6 months or so, the nation has paid so much attention to clinical trials for COVID, and I think we've all learned a lot. I was wondering how does … tell us a little about clinical trials in vision. Is it similar to how the clinical trials were that got us the COVID vaccines?
DR. DAVID LIAO: Sure. Yeah, I mean, all of these trials, we have to do them, and we do a lot of trials for macular degeneration here at the clinic, but they're running conjunction with the FDA and the sponsor. And really, they're trying to get new drugs, obviously, out to the market, but FDA really wants the drug to be safe; their job is to protect patients, as all our jobs are, and they want the drug to be tested in a very specific way. So, basically, these new medications already had some preclinical data and small trials or tests, perhaps in animal models, that show they are fairly safe, but we don't really know until they're tested in people.
Basically, if you have a certain disease, like geographic atrophy, and you're interested in a trial because there is no approved treatment, then you go to your retina doctor, for example, and discuss trials with him or her, and they'll see whether your eyes are appropriate for the trial first because they want to do statically analysis and really prove that the medication is doing what it's doing, so they have sometimes fairly strict entry criteria. For example, you have to have severe geographic atrophy or maybe moderate geographic atrophy—and each trial is a little bit different—they'll do what's called a screening exam and do complete eye exams and see whether you meet all these criteria. After that, they'll go ahead and enter you into the trial if all the criteria are met. And usually, they're comparing an established treatment, if there is an established treatment, or a placebo—a sugar pill, if you will—if there's no treatment. And you'll get assigned to one of these two groups. You might not necessarily know during the trial, but they'll certainly reveal that to you after the treatment, During the trial, you'll receive the treatment, and you'll get very close follow-up, they monitor you very closely for any side effects, and they'll take pictures and so forth to assess the role of the drug and see how the geographic atrophy is progressing. After that, then they take a look at all the data, and they see over a large number of people: Does this drug really work? And if it's safe, and after that, they will apply to the FDA, and that will be approved for general use out of the populations.
I also remind my patients that this is not an obligatory thing. Folks that, for whatever reason, decide they don't want to participate in the trial, they can just exit the trial. Those types of things patients often have concerns about, and it's really a working relationship between you and your doctors. So, the doctors are really trying to do whatever is best for you, and the advantage sometimes is it takes 3, 4, 5 years for these medications to get approved, and a lot of times we saw with the wet macular degeneration studies that folks got medicines before they were on the market, so that's sometimes a huge advantage. But sometimes the drugs turn out not to be as effective, and they don't get approved, but that's why we do the studies, and they're very helpful to society as a whole to get new medications out there and to get conditions treated that we never really could treat before.
MICHAEL BUCKLEY: I think you're exactly right. I do feel like there is a pay-it-forward type of citizenship there. When you and your patients talk about possibly going into a clinical trial, are there common questions or concerns that you address from your patients?
DR. DAVID LIAO: Sure, sure. Yeah, so folks who are certainly concerned, a lot of folks … it's an experimental medication, and they're certainly concerned if it's safe or not. And the FDA and the trial monitor folks very closely to make sure that they don't have any side effects, and if there are significant side effects that, they'll stop the trial. The patients often ask, "If I get tired of the trial, am I obligated to stay in it?" And the answer is "no." It's totally voluntary, and folks can exit the trial whenever they need to. It's just a voluntary participation, and if you feel like you're getting a benefit out of it, then certainly continue, and, hopefully, these medications prove to be better than what's available on the market—which, unfortunately, for geographic atrophy at this time, there's really not much.
MICHAEL BUCKLEY: Thank you. Dr. Liao, we just got a question about clinical trials. Are there any that would have people who have the geographic atrophy in one eye but also wet in another? Is there research on clinical trial opportunities for these folks?
DR. DAVID LIAO: Sure, yes. As I mentioned, certain trials have different entry criteria, and there are trials out there for geographic atrophy that do have requirements for both eyes to be dry, but there certainly are trials out there that it's okay if one eye is wet. And I believe … I'd have to check the inclusion criteria, but there also are studies out there that are looking at treating geographic atrophy with gene therapy; I didn't mention in the earlier discussion, but I believe that trial also does include folks who have wet in one eye, but I'll have to check. Any questions like that can certainly … folks can question their local retina doctor, or they can be referred to a clinical trial center; they'll have all that information available to them, and they can go through it step by step.
MICHAEL BUCKLEY: Thank you. We have a number of people submitting questions today about vitamin supplements—specifically, the AREDS product that's available over the counter. I was wondering if you could tell us a little bit about AREDS—both who is it right for and who is it not right for? It seems to be the core of the questions today, people wondering, will it help them or not?
DR. DAVID LIAO: Of course, yeah. Because you see advertisements on TV and in magazines and everything, but the, basically, how the AREDS came about was there were these large landmark clinical trials, actually, for vitamin supplementations conducted by the NIH. So, we know that people that have diets that are lower in antioxidants tend to have more severe macular degeneration. The AREDS supplements are basically antioxidants, and so the AREDS1 study, a certain formula of medication … of vitamins, and they showed that they could decrease your risk of getting wet macular degeneration by taking this supplement formulation. Now, that initially had beta-carotene in it, and they found out that beta-carotene sometimes gives smokers a higher risk of developing lung cancer, actually, at the doses that were in the trial. In the AREDS2, among other things, they took that out, and they found that that vitamin supplement without beta-carotene actually did just as well as preventing the wet macular degeneration. Now it doesn't really prevent geographic atrophy, unfortunately. It's more for wet macular degeneration. But that is a significant side effect of macular degeneration, so still a very useful tool.
For folks who don't necessarily have macular degeneration, it's not really necessary to take those vitamins. It's more … when you're at that stage, it's more advisable to simply take a multivitamin, eat a healthy diet with a lot of antioxidants and omega-3s—spinach, kale, broccoli, salmon once or twice a week—and that's sufficient. Even if you have a family history but you don't have any symptoms of macular degeneration, that's probably all you need. Now, when you start to develop early or certainly moderate macular degeneration, that's when your doctor will start advising you to considering taking the AREDS supplement, because that's when you're more at risk for developing wet macular degeneration.
MICHAEL BUCKLEY: Thank you. It's very helpful, because you see these ads on TV, and it gets your mind wondering a little bit. Several people have left us questions today about AREDS wondering about zinc, that they have heard that there could be a problem with too much zinc in their nutritional supplements. Is that something you can comment on?
DR. DAVID LIAO: Sure. Yeah, so they did see in the AREDS study that zinc did cause some side effects, such as actually stomach upset and those things, and there is a theory out there … there's all these …there was a boom a few year back in genetic testing for macular degeneration because there are certain genes that predispose you to getting more advanced macular degeneration, and there was a theory that they found a trend in the data that certain types or combinations of genes predispose you, perhaps, to getting more macular degeneration if there are high doses of zinc in the vitamins. The authors of the study noted that, and they themselves actually don't advise routine genetic testing for genotypes of macular degeneration, because it's more of research type of tool, but the newer formulations have less zinc, and they're equally as effective. I think if you're taking the AREDS2 formula, I mean, that's proven to be fairly safe. There are some theories out there that they're actively looking at, but at this point, we don't necessarily know. And the AREDS2 study was done over a large number of patients. For the patients as a whole, that was a safe dose to take.
MICHAEL BUCKLEY: Thanks. You may have touched on this a couple of minutes ago, but we had a caller wondering about, if they're not a smoker, is AREDS1 still available, and is a nonsmoker better off with AREDS1 or AREDS2?
DR. DAVID LIAO: Right, right. So, the primary reason, as we mentioned, was that for smokers, AREDS1 did cause an uptick in lung cancers. Now, when they compared the formulas in AREDS and AREDS2, there was really no difference in the protective effect, so either one would be fine. I believe the AREDS1 is still available, but most of the formulas out there are now the AREDS2. I would just advise them to consider taking the AREDS2, since it's just as effective, and that's probably easier to get now, actually.
MICHAEL BUCKLEY: One last question on the AREDS; we got a number of questions on that today. A caller has some concerns that … could AREDS ever accelerate the progression for AMD? Does it ever work in the opposite direction?
DR. DAVID LIAO: In the opposite direction? Yes. So we had alluded to that earlier; there was this possible trend that for certain combinations of genes, it might do so. But that's not really definitive at this point, so at this point, we have good data that for the general population that AREDS is protective. The other issue that's out there is somewhat controversial at this point, so the answer is that I don't think we have a good idea, but we do have good data that the AREDS is protective. So, we'll wait and see if there's any other information that comes out, and I think if they found that to be the case, they would certainly publicize that.
MICHAEL BUCKLEY: One more question before we move into our concluding remarks today. About the mental health toll of an AMD diagnosis and about quality of life, when you talk with your patients and you see some—and I think there will be very, obviously, stress and worry, what do you say to them and just, in effect, how do you do it operationally, how do you guide people toward different apps or devices, or how do you help people live as best they can?
DR. DAVID LIAO: Sure, yeah. I mean, the first thing I tell people is because in earlier times in macular degeneration, the diagnosis would be a diagnosis of blindness. At this point, that's not the case. We have good treatment, especially for wet macular degeneration—and we're getting good treatments, I think, for dry macular degeneration—but there's no question, there's going to be some vision loss associated with that and that affects your quality of life. Things we all like to do—read; watch TV; driving, even. But the goal, I think, is to keep a positive outlook and to maximize the vision that you do have, which still can be pretty good. I have lots of patients with macular degeneration that really just live full lives; they go about their everyday lives without too many problems. There are some inconveniences, like we all have, but as the vision loss starts getting more, there are simple things you can do: use more light, use magnifiers, and so forth.
But there are cases where it certainly is more severe, and those cases I like to work with a low vision therapist. In most cities, there are centers—in Los Angeles, there's the Braille Institute that's does a great job. There are superb groups out there, like the Foundation Fighting Blindness, that can get folks in touch with low vision specialists, and there are individual doctors in each city that will do these specialized devices and will help folks order those types of things that can people with apps and things like that. Even sometimes just your nephew or something can help you go to the app store and download these magnifiers that you can get on the iPad or simply blowing up the font and so forth. The goal is maximizing what you have, and there are certainly professionals out there—low vision therapists—that do a great job of making devices available that can really help in the day-to-day life.
MICHAEL BUCKLEY: Thank you. Dr. Liao, before we conclude, I just want to thank you very much for just giving us a lot of … a lot of reasons for hope, a lot of specific examples of the field of vision research making some really exciting progress. I was wondering if you could leave us with something "big picture," sort of one big thing you feel like you've learned in your career, or is there one piece of advice that you'd wish all your patients … you want to make sure all your patients know about, or is there something you want to end with today?
DR. DAVID LIAO: Sure. Yeah, yeah. I think the big picture is things are always improving, things are always getting better, and staying in touch with your doctor and learning about these clinical trials, learning about other options, like low-vision therapy that are out there, can really keep you abreast of all the things that are going to on. And there are certainly things out there today that weren't around 5 years ago, so the field is consistently changing. There's certainly hope out there to provide longer quality vision and, perhaps, even better quality vision in the future; we're living in exciting times. Hopefully, the COVID will go away, but for macular degeneration, I think that the future is bright. I mean there are lots of treatments out there or coming available that will likely change and shape the way we treat this and change the prognosis in the very near future.
MICHAEL BUCKLEY: That's good to hear. Dr. Liao, on behalf of BrightFocus Foundation, I'd just want to thank you so much for coming back a second time. I think you've really given us a lot of hope for the future.
DR. DAVID LIAO: Thank you for having me. It was a pleasure.
MICHAEL BUCKLEY: On behalf of BrightFocus Foundation, this concludes this month's BrightFocus Chat. Thanks so much for joining us, and we will be back April 28. Thanks.
Useful Resources and Key Terms
BrightFocus Foundation Live Chats and Chat Archive
Clinical Trials: Your Questions Answered
Healthy Living and Macular Degeneration: Tips to Protect Your Sight
How Low Vision Services Can Help You
Macular Degeneration: Essential Facts
Research funded by BrightFocus Foundation
The Top Five Questions to Ask Your Eye Doctor
Treatments for Age-Related Macular Degeneration
Understanding Your Disease: Quick Facts About Age-Related Macular Degeneration (AMD)
Other resources mentioned during the Chat include—
AREDS1 and AREDS2
Avastin, Lucentis, Eylea, and Beovu
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While more statistics on distracted driving and other dangerous driving behavior are having an impact on road safety, car manufacturers are creating new technologies that could really make a difference on safety.
In fact, the most modern vehicles are equipped with safety features that help protect drivers, passengers, and pedestrians.
However, your role as a buyer is to determine which car safety features are the perfect additions to your vehicle.
As car buyers portray different needs and expectations, let's just focus on the latest features that are available on the market to better determine what really makes sense for you to stick to.
Check out these new car safety features and feel free to let us know if you would consider them for your next purchase.
This is a great add-on since you no longer need to be uncertain about your blind spots. This new technology alerts drivers of anything getting too close to their vehicle.
Systems with autonomous braking also back up warnings with an automatic application to the brakes. Our research shows that both help reduce crashes.
Headlights are smart enough to give you assistance while on the road. They have been improved and adjusted so you could improve your visibility while making challenging maneuvers.
Adaptive headlights are becoming increasingly popular since it has been discovered that they lowered property damage liability claims by approximately 10%.
If you want to feel more protected, it is recommended that drivers also include HID headlights, adaptive high-beam support, and night view technology on their checklist.
No longer will you need to be concerned about your blind spots while on the road owing to the use on sensors on modern vehicles.
These sensors could easily alert you of any vehicle or other objects in your blind spot.
Whether or not it's effective, when we've talked to vehicle owners with cars equipped with blind spot detection, they universally agree it's a good thing.
If you are planning to buy a new car, take heed of the latest car safety features and never be afraid of asking for the safety performance of any vehicle model you may be interested in purchasing.
Do you know of any new car safety feature? Have you tested any of the above-mentioned features? Feel free to let us know on the comments below.
The 5 Most Common Myths About Classic Cars. #4 Is Ludicrous!


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Donald Trump representatives move in on the Macau trademark
August 8, 2017. By Stefan
Hong Kong Reuters were recently granted approval to have additional trademarks from the Chinese jurisdiction of Macau. This company has been linked to the United States president Donald Trump. The additional trademarks include casino services, which is to develop the 'Trump' brand.
A slice of pie
Online documents from the Macau government are reported to include construction and development, real estate services, hotel property, food and beverage, as well as conference facilities. Despite the fact that Trump has handed over his business to a Trust, which his son is said to be overseeing, it is clear that Trump is still linked to the Trust financially.
Trump has been in the gambling industry for some time. He was once a commanding figure in Atlantic City. According to the New York times, his casinos accounted for nearly a third of gambling revenues in the early 1990s. However, by 2009 he had lost control and went through a series of bankruptcies.
The licenses of Macau's six casino operators will begin to expire on 31st March, 2020. Macau hasn't made it clear whether or not these operators will be allowed to continue operations beyond this point. Nor have they shed any light on new bidders being allowed to enter the market.
The latest trademarks that Trump is linked to really does speak volumes. Trump looks like he is still trying to grab a slice of the pie. Ben Lee is gaming analyst and released a statement that said "His children constantly scout the globe looking for new businesses and to expand the Trump brand. Given that this trademark application comes a few years before the concession renewal between 2020 and 2022, one has to consider the possibility that he may look at applying for a new concession."
The Word on Wall Street
Last year, the Wall Street Journal reported that Trump had bid for one of three Macau licences. This was done along with other investors, which included the Macau billionaire Ng Lap-seng. Last month, Lap-seng was convicted of bribery and money laundering.
Glen McCartney is an associate professor in international integrated resort management at the university of Macau. He says that "A Trump partnership is a possibility, but to register trademarks is a common business practice. He went on to say that "It does not mean that it will necessarily be materialised." He said it might simply be a "defensive measure", so no one can use the logo or brand in Macau.
In 2012, the Macau government accepted Trump's request to register three brands: "Donald Trump"; "Trump Tower"; and "Trump International Hotel and Tower". However, according to experts, it's too early to tell how supportive Beijing will be of a gaming project involving the current US president in Macau.
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History was made when President Barack Obama was elected the 44th President of the United States of America. I'm the mother of two mixed-race children, so I like to think that this event was ever more important for our family. My children face adversity and racism almost daily. They see the struggles that many African American people endure, and I believe that this historical event showed my children what they can accomplish.
That's why when I was offered to review the book The Obama Time Capsule, I was excited and enthralled. I was excited because this book is a keepsake and I was enthralled because it's a book that spans a two-year time period, covering President Obama's road to the White House, Election Day, the inauguration, and his first 100 days in office. Another reason I was enthralled is that you can personalize this book with your child's name.
I chose to use my son's name in this book, since I've watched him endure racism almost daily, and he's overcome so many adversities in his short life. I truly believe that this book can be a great influence in his life, and that with it, he will know that he can truly accomplish anything.
The Obama Time Capsule is essentially a customized book that allows you seamlessly add your personal pictures and thoughts to the existing professional photos and essays documenting Obama's journey to the White House. The book contains beautiful photographs and essays and gives users the ability to insert themselves into a piece of history. For some additional insight, please check out the HP commercial on YouTube which provides a great visual of what the book is all about, as well as recent broadcast coverage from ABC Evening News.
It's so trite, but kids do grow up so fast. As a mom who is witnessing their incredible growth, I'm always taking photographs and videos to freeze frame the moments in our young children's lives. We are always in pursuit of chronicling their daily existence and in that vein, chronicling the world they were living in at the time. Theirs is the first generation to experience something unprecedented in the history of our country and that is of course, having an African-American President. Regardless of which side of the political table you sit at, there's no doubt that Obama's presidency will have a major impact in our children's futures.
On the cover of the book, which you unfortunately can't see in the first photo, my son is listed as one of the authors, which we all thought was so cool!
Photo inside the book of The President and The First Lady at just one of their inaugural balls.
Aside from the personalization aspect of this book, I love the entire book! There's great quotes from President Obama, as well as many other prominent figures, TONS of facts, and countless great photos. Even though my son is technically the "owner" of this book, I am so proud to have this book in my home. Never in my life did I think that I would see an African-American be elected as President of our great Nation, and now I am the proud owner of The Obama Time Capsule, a great keepsake, with my son listed as an author! We can pass this down from generation to generation and I'm sure that it will stand the test of time due to its quality. The book is excellently made!
Thank you to my sponsors for providing me with the opportunity to review this great book! My son and myself will cherish it always!
Great review Angie - we love our Time Capsule book too. One of Taylor's favorite parts was the message on the blackberry in the book!


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PLOTE member shot dead in Vavuniya
K.Uthayakumar alias Kannadikumar, 38, a senior member of the PLOTE military wing was shot dead around 7.30 p.m. this evening by an unidentified gunman near his house in Kovilkulam, a suburb of Vavuniya.
A person identified as Kopalan who was also in the shop was wounded by the gun fire.
The gunman who was riding the pillion of a motorcycle had opened fire with an assault rifle, killing Uthayakumar on the spot.
He and his accomplice had sped away on the motorcycle before PLOTE cadres rushed to the area said sources.
The wounded person was rushed to the general hospital in Anuradhapura.
The PLOTE's military wing has its main office and safe houses in Kovilkulam.
The area is considered a stronghold of the Tamil group.


Our Game Tables for hire will excite and delight your guests at your next event. We are able to supply some of the best-loved arcade games including; Air Hockey, Table, Pool Table, Football Table, Darts Board and more. Allow our fun arcade games to take you back to a simpler moment in time.
These Game Tables are a fun entertainment option that the whole family can enjoy. It is also a great way to challenge each other, and battle it out to see who will be crowned the queen or king of the arcade.
Our Game Tables are the perfect form of entertainment to book for your event. Our versatile tables are compact and easy to arrange and can, therefore, be set up indoors or outdoors. These Game Tables would be perfect for private parties, family fun days, weddings and much more.
If you would like to view more entertainment to hire for your family fun day, then please take a look at our Pinterest board below. We also have a second Pinterest board where you can view more exhibition entertainment to book for your event in London & the UK.


Cut squash in half lengthwise; scoop out seeds. Place squash cut side down in a baking dish. Fill pan with hot water to a depth of 1/2 in. Cover and bake at 375° for 50-60 minutes or until tender.
When cool enough to handle, scoop out the squash and separate strands with a fork. Place squash in a large serving bowl and keep warm. Discard shells.
Meanwhile, in a skillet; saute mushrooms, zucchini, red pepper, peas, onions and garlic in oil and butter for 15 minutes or until tender. Add tomatoes, basil, garlic salt and pepper; heat through. Pour over squash. Sprinkle with Parmesan cheese.
1 each: 117 calories, 5g fat (2g saturated fat), 6mg cholesterol, 195mg sodium, 14g carbohydrate (3g sugars, 4g fiber), 5g protein.
This was an OK recipe. Not sure if I would make it again. Tasty but too much work for me.
Tasty way to serve veggies. My husband enjoys some meat with his meals, so I have also made it adding some cubed chicken breast and it was very good.
Very tasty. I tossed the sautéed vegetables in with the spaghetti squash instead of serving on top of the squash to incorporate the flavor better into the squash.
This was really good! I usually just make spaghetti squash with prepared pesto or marinara, but the fresh veggies really added a nice flavor. I didn't add the peas, but I added everything else and it was great.


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Climate change: the technical sector's role and responsibility | Engineers Without Borders Panel
Dr Bronwyn Evans, Engineers Australia CEO
Engineers Australia is the profession's peak body, with around 100,000 individual members. Our purpose, as per our Royal Charter, is to advance the science and practice of engineering for the benefit of the community.
That last little bit – the benefit of the community – is key when it comes to climate change.
Engineers have a vital role to play in increasing renewable energy and developing more sustainable transport, reducing the energy needed to create building products and electronics, increasing the durability of our manufactured goods and adapting to our changing climate.
Engineers get into engineering to make a difference to their communities – and they can be leaders in making the changes we need.
As data-driven, scientifically literate professional problem solvers whose work impacts almost every area of modern life, it is our duty and our desire to be "part of the solution".
Importantly, the community trusts engineers.
Typically, engineers are highly aware of deadlines, design standards, budgets and safety. Sustainability is in the mix, but we need to move it higher up the list of priorities to be firmly top of mind. We need to innovate and to change the way we do things in response to a changing world.
We need to consider alternatives that can meet a goal. For example, do we need this new power plant? Can we instead use demand management, paying big users to suspend operations when supply is short? Do we need a new roundabout, or could the traffic problem by solved by changing the sequencing on traffic lights?
Unfortunately, politicians like to cut the ribbon on shiny, new structures, which means sometimes alternatives are not truly considered.
Engineers Australia has a Climate Policy and a Sustainability Policy and our members are also bound by a Code of Ethics which requires them to promote sustainability by:
• Engaging responsibly with the community and other stakeholders
• Practising engineering to foster the health, safety and wellbeing of the community and the environment and
• Balancing the needs of the present with the needs of future generations.
That Code of Ethics also applies to non-members who are part of the National Engineering Register.
One of the challenges is that in many parts of Australia there is no requirement for engineers to be registered, and thus no need for them to comply with any Code of Ethics.
As Elizabeth Farrelly of the Sydney Morning Herald commented "unregulated engineering makes sense like unregulated brain surgery"!
We are advocating for laws requiring registration of engineers as is currently the case in Queensland, and on the way in Victoria.
Policies are one thing, but implementing them is another. For this reason, we have produced a detailed guide "Implementing Sustainability: Principles and Practice" that is available to members free of charge. It is currently being updated.
This is a very practical tool linking to other resources that recognises the reality that most, if not all, engineering activities do require resources – energy, land, water, materials – and do have impacts. Sometimes remediation, recycling or offsetting is the "least bad" choice. Sometimes it is the role of the engineer to educate the client on sustainability and the options available to them.
One of the things that peak bodies can offer is an opportunity for people to come together and, as a group, achieve more than they could alone – our volunteers in the Sustainable
Engineering Society and our Environmental College work to advance the cause, upskill our members through professional development and inform our advocacy.
If members want to become Chartered engineers, one of the competencies they have to demonstrate is that they develop solutions that are both safe and sustainable.
Our members are active in innovating climate solutions, and sustainability is one of the criteria we evaluate when recognising engineers and engineering projects in our awards. If we take a few examples from last year…
Our most recent 30 Most Innovative Engineers list included members like:
• Steve Wilson, from Aurecon, and his work on the world's largest lithium-ion battery system in Australia, enabling wind power to be stored and building confidence in the ability of such large storage schemes to be successfully integrated into the electricity markets.
• Julian O'Shea, whose zero emission solar-electric tuktuk travels at 50 kilometres an hour, has already been across Australia and is now attempting to make it round the world.
• Amelia Milne from Aurecon, recognised as one of Australia's most innovative engineers for her work designing the Melbourne Conservatorium of Music to be zero carbon ready – with no use of gas for heating and cooling, and with solar panels.
We also saw our member – and Australia's Chief Scientist – Dr Alan Finkel, deliver Australia's hydrogen strategy to COAG, creating a pathway to commercial use of hydrogen created with clean energy being made in Australia for industry, transport, heating and export. Hydrogen, when burned, creates water.
Our Young Engineer of the Year, an environmental engineer, is working to reduce the impact of the electricity network on the iconic Tasmanian Wedge-Tailed Eagle.
Sustainability was a strong theme throughout the World Engineers Convention, which we co-hosted in Melbourne late last year. We are building on that via a roundtable we will hold later this month, which will bring together leaders from engineering and non-engineering backgrounds.
If we work together, we can leave a powerful legacy that we can be proud of, as a profession, and as people.


Don't want to read? Check out the youtube playlist!
St. Paul, MN – The expansion of a color portfolio can ignite creativity and kindle the inspiration behind exceptional wrap designs. 3M is committed to offering graphics installers the best products possible, and has thoughtfully developed ten brand new colors to join its popular, ever-evolving 3M™ Wrap Film Series 1080 family. The collection of new shades will usher in a new wave of innovative wraps by refreshing a shop's repertoire with eye-catching finishes in reds, purples, holographic hues and more.
These dynamic additions to Wrap Film Series 1080 increase the design potential that installers can explore, and come available in gloss, satin and color-flip finishes. The new class of colors includes: Satin Thundercloud, Satin Vampire Red, Satin Caramel Luster, Gloss Lipstick Red, Gloss Black Cherry, Gloss Wicked and Gloss Plum Explosion. The trio of new color-flip options – Gloss Flip Deep Space, Satin Flip Volcanic Flare and Gloss Flip Psychedelic – invoke cosmic depth and prismatic gleams, perfect for adding a unique and individual touch to any project.
This expansion of the 3M Wrap Film Series 1080 line brings its color total to 98 options. Made in 60" wide rolls so installers can easily cover vehicle sections without seams, Wrap Film Series 1080 is backed by the 3M™ MCS™ Warranty, providing installers confidence that the films will last and live up to their guarantees.
3M recently implemented a new design on the back of the liner for Wrap Film Series 1080 products. An arrow emblem has been added next to the 3M logo indicating web directionality. These arrows will assist installers with keeping films oriented correctly for a consistent install.


Home » Ask a Bible Teacher » Life Before Conception?
Does it say anywhere in the Bible if souls are created at conception or if there exists a finite number of souls that were created at the beginning of time?
The way I read Psalm 139 every part of us came to be at the moment of our conception. Although God was aware of every day of our existence before time began, and knows exactly how many of us there'll eventually be and which of us will choose Him, it's because He's outside of time and knows the end from the beginning. To say that any part of our being existed prior to our conception is to flirt with the idea of a pre-existence, a concept from Eastern Mysticism that can't be supported Biblically.


Richard Jesse Watson comes to San Diego!
Richard Jesse Watson will open SCBWI San Diego Illustrator & Agents Day, beginning at 8:00 am on February 11, 2012.
Prepare to be enchanted and inspired! Richard will share his love for books, his circuitous path to becoming published, plus exercises in craftsmanship. Loosen your imagination, tighten your writing, and fire-up the artist within. Yes, this is for both artists and writers!
Most recently, two of his titles, The Lord's Prayer (with commentary by Rick Warren/ZonderKidz) . . .
. . . and The Night Before Christmas (Clement Moore/HarperChildren's) were on the NY Times Best Seller lists.
Richard and I worked together on three of his previous books: Bronwen, the Traw and the Shapeshifter (AIGA Award Winner,); Tom Thumb (SCBWI Golden Kite Winner, 1990). . . .
. . . and The High Rise Glorious Skittle Skat Roarious Sky Pie Angel Food Cake (below).
Following Richard Jesse Watson, there will be a panel of San Diego agents. What do literary agents look for? What not to do when submitting your work? What's selling in today's market? With many publishing houses not accepting unsolicited work, enlisting a knowledgeable agent with a proven track record is essential to a children's book career.
Tip: If you are in the southern California region, consider coming down for the day via Amtrak. USD is a 5-minute cab ride from the Old Town Station.
Spaces are filling fast! Go to www.sandiego-scbwi.org, and click on the conferences button for the day's agenda plus details on registering.


Road to X Games: Boise Park Qualifier Live June 15 and 16 on X Games Facebook, Twitter and YouTube Pages - ESPN Press Room U.S.
As part of the Road to X Games content series, X Games will host the world's top athletes in a Park Qualifier event on June 16, 2018 as they compete to secure their invitation to X Games Minneapolis. Held at Rhodes Skate Park in Boise, Idaho, the Park Qualifier will feature three disciplines – Men's Skateboard Park, Women's Skateboard Park and BMX Park. New in 2018, the event will also host a Harley Hooligan race at CenturyLink Arena on June 15.
*Times and events listed are Eastern Time (ET).
The park competitions will be streamed live via X Games Facebook, Twitter and YouTube pages. In addition to the live stream, fans can catch the Boise Park Qualifier coverage across X Games digital and social platforms as well as part of the World of X Games on June 23 on ABC.
The Hooligan event will also be live-streamed around the world via Harley-Davidson's Facebook page, X Games Facebook page, H-D dealers' and industry partners' brand pages.
Members of the press interested in covering the Road to X Games Boise Park Qualifier may email [email protected] if interested in applying for credentials.
The latest press releases regarding this event are available at www.espnmediazone.com and photos are available at www.espnimages.com.


Like many comic book fans, once Nick Coglianese started collecting, he was hooked. As he hunted down first appearances and major key issues, he became addicted to that particular moment when the eyes recognize something special but it takes the brain a split second to believe it. A superhero fan since he saw Tim Burton's Batman on the big screen, Coglianese recently entered the industry in his own way, helping comic book fans track and find the most collectible comic books with his app Key Collector.
With Key Collector, Coglianese has made it that much easier to find and track key issues. For instance, last month Key Collector has curated a list of optioned independent comics, listed the first appearances of every version of Iron Man's armor and put together a list of the most collectible issues that may play a part in Captain Marvel. With Key Collector, Coglianese put in hundreds of hours of research to create an app focused exclusively on "keys" — first appearances, origins, classic storylines, iconic covers, rare and recalled issues, low print run and a number of other factors that can contribute to a comic book demanding value over another.
Launched at the New York Comic Con in 2017, Coglianese's Key Collector app has reached the 75,000 download mark, received praise from people like Neal Adams and Alex Ross, and is expected to exceed 1,000 paid subscribers next month. In conjunction with the app, Coglianese launched a YouTube channel and a website where he blogs about comic book speculation and collecting. While the app, site and YouTube channel are free, Coglianese's subscription service offers perks like notifications about green-lit TV and movie properties, specialized lists and more.
Like many kids of his generation, Coglianese's world changed when Tim Burton's Batman arrived on the big screen in 1989. Immediately after seeing the movie, Coglianese became obsessed with comic books and even tried his hand at both drawing and writing comics, but things just never panned out. As Coglianese grew up, he settled into a career for a liquor distributor, but he never lost his passion for comics.
In his distributor career, Coglianese spent countless hours on the road working in Chicago and then in Wisconsin, so to help break up the day he'd always stop at antique stores or used bookstores. Searching to find buried treasure of sorts, Coglianese became addicted to those rare heart-stopping moments when he'd be flipping through a longbox and out of nowhere: Comic book gold.
"I had lists on my phone of the key issues I needed to make sure I looked for. I feel as collectors we're curators of these fragile and finite articles of our pop-culture, superhero history," Coglianese recalls.
After amassing more than 20 longboxes full of Spider-Man, Batman, Spawn, Sandman, Lucifer and X-Men issues, Coglianese found that keeping and storing that many comic books wasn't feasible, so he sold most and just kept the keys.
Everything changed for Coglianese when he first walked into Downtown Books — Bought and Sold in Milwaukee, Wisconsin. When just minutes after entering the store he spied a copy of Uncanny X-Men #221, which marked the first appearance of Mr. Sinister, Coglianese knew he had hit pay dirt.
"After going back a couple of times I asked the owner if he had more comics," he says. "He informed me that he owns a warehouse with over 50,000 comics that haven't been looked through for a long time because he didn't know what was what. I offered to help him out, pull out the key issues and if there was something I really wanted, to give me a good deal. So that's what we did."
Over the next few months, Coglianese pulled copies of Preacher #1, New Mutants #87 (Cable's first appearance), Amazing Spider-Man #300 (Venom's first appearance), and Uncanny X-Men #266 (Gambit's first appearance) as he searched through longboxes and navigated the owner's offsite warehouse. Admittedly, Coglianese said, the process took ages and even started to take its toll on his job and relationships.
"I get a little obsessive," he says. "I needed to get through that project faster and did a search for a key issue database, a search that had done multiple times before but to no avail. I just thought, 'Why don't I make it myself?' So I did."
Nick Coglianese is the creator of the Key Collector app.
When creating the app, Colgianese says he build Key Collector with the goal of making comic collecting more fun and accessible to any collector at every stage of the game, from total beginner to seasoned veteran.
"There is a lot of territorial thinking in comic collecting, that you have to earn your stripes in order to have the bevy of knowledge that allows one to identify what's valuable by rote but to me, that's just selfish thinking," Coglianese explains. "The only result that comes from that type of thinking is newer collectors getting ripped off and possibly discouraged to the point of walking away from the hobby."
Currently, the Key Collector database has surpassed 12,000 comics and continues to grow. Each week, Coglianese updates the "Keys This Week" free feature that lets collectors know what's hitting the shelves on any given Wednesday.
"If collectors think that there is a reason why they are getting a key issue alert or a reason why something is appearing on the site that is in the best interest of Key Collector Comics then we lose credibility and we're nothing," he says. "That's why I made it a hard-stop at any conflict of interest in buying or selling comics. I'm like Uatu, The Watcher. I observe. I report. And I want people to know that Key Collector Comics is there as a loyal and reliable sidekick in this comic collecting adventure."
So how does a copy of Avenging Spider-Man #9 (the first time Carol Danvers adopts the moniker Captain Marvel) go from a few dollars upon release to a few hundred? It's all about the development deals. According to Coglianese, as TV and movie producers have been buying up comic IP at a breakneck rate, it has had a fiery effect on the comic book market.
"A comic book property is announced or a character cast and that premiere issue or first appearance can go from the dollar bin to being worth $20-$50 and up," he explains. "The character Rescue is a good example. Pepper Potts, Tony Stark's girlfriend, suits up in Iron Man armor in the upcoming Avengers: Endgame movie and the corresponding comic goes haywire."
With speculation driving the prices of certain comic books up astronomically, the market ballooned. The first appearance of Black Knight (Avengers #48), for example, has almost tripled in a few months alongside speculation that he may appear in the new Avengers movie. Other reasons a book may get hot include when a creator brings a character up from obscurity in a major storyline or a hidden gem is uncovered.
"It's like the pop culture stock market and comic buyers are the stock traders," he says. "It's a lot of fun and I feel it gives fans the opportunity to do something with their money that hearkens back to what they enjoyed when they were younger but now has an adult twist to it which is this buying, selling and investing."
That said, Coglianese still believes comic collecting isn't all about investing or making money off of comics.
"I think it goes without saying that if collectors were purely driven by turning a profit there are plenty of other ways to gamble," he says. "People love the characters and stories and this is just added excitement to the hobby. Some enjoy having a valuable collection."
For Coglianese it's always been about the hunt, tracking down a comic and negotiating the little slice of comic history.
"There are a lot of collectors like that," he continues. "Everyone has their own relationship with comics whatever that might be and it's okay as long as they're involved and not trying to scam the less knowledgeable."


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NBA Draft 2020: Which team has the most draft picks?
Eight teams have at least three picks in the 2020 NBA Draft with one franchise owning five. Which franchise has the most? Find out.
The 2020 NBA Draft will be held virtually at ESPN's Bristol, Conn. studios on Nov. 18 at 7 p.m. ET.
In the first-ever NBA Draft held at ESPN, Commissioner Adam Silver and Deputy Commissioner Mark Tatum will appear in studio to announce the draft selections in the first and second round respectively.
By winning the 2020 NBA Draft Lottery for the second time in franchise history, the Minnesota Timberwolves have the No. 1 pick in the 2020 NBA Draft. They have a total of three picks in the 2020 Draft - Nos. 1, 17 and 33.
MORE: All you need to know about the 2020 NBA Draft
The Timberwolves are one of eight franchises that have three or more selections in this year's Draft. Here's a quick look at the teams with the most picks at the 2020 NBA Draft (includes all with at least three picks):
Team Total Picks Round (pick No.) Round 2 (pick No.)
Philadelphia 76ers 5 21 34, 36, 49, 58
Sacramento Kings 4 12 35, 43, 52
New Orleans Pelicans 4 13 39, 42, 60
Boston Celtics 4 14, 26, 30 47
Minnesota Timberwolves 3 1, 17 33
Golden State Warriors 3 2 48, 51
Charlotte Hornets 3 3 32, 56
New York Knicks 3 8, 27 38
Only one NBA franchise has no draft selection in the 2020 NBA Draft - the Houston Rockets.
They are among three other teams that don't own a first-round pick: the Indiana Pacers, LA Clippers and Memphis Grizzlies.
Meanwhile, there are eight teams apart from the Rockets who don't own a second-round pick - Cleveland Cavaliers, Milwaukee Bucks, Los Angeles Lakers, Denver Nuggets, Miami Heat, Phoenix Suns, Utah Jazz and Detroit Pistons.


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iBelieve Celebrates iPod Obsession
Apple really does win the prize for undying brand love. Either that, or the religious freaks over at iBelieve have been converted to religion iPod and intend to convert all iPod owners to their cause. Actually, it's just for fun and the site says it's "inspired by the world's obsession and devotion to the iPod, iBelieve is a replacement lanyard for your Shuffle. It is a social commentary on the fastest growing religion in the world." To further this obsession, iBelieve is offering a lanyard for the iPod Nano that looks like a cross and sells for $12.95.
by Steve Hall Nov-14-05 Click to Comment
Topic: Consumer Created