text:
articles/pursuing-patient-centricity-from-start-to-finish
Pursuing Patient Centricity from Start to Finish
October 2, 2018 PAP-Q3-18-NI-005
Nice Insight
The Outsourcing Issue Feature: Part 1
The journey toward patient centricity can be introspective. Trying to solve for improved patient outcomes and improving the overall patient experience requires a top-down review of an organization's internal drivers. Although the endgame for the industry as a whole is to keep the patient a priori in all situations, a divided supply chain, coupled with all the elements of bringing a drug to market, can make a streamlined focus on patient centricity challenging. There are numerous organizational obstacles to overcome before the patient experience is placed top of mind throughout the value chain. However, an internally motivated patient-centric mindset adopted by every CRO, CDMO and packaging and supply chain player has the ability to positively impact the industry from start to finish. This is especially true if the heads of all organizations consider what their company could be doing differently — and how they can implement these changes for real-world, value-based results.
Internal Interruption
Speaking to an audience at the annual eyeforpharma event, Jim Robinson, President and COO at Alkermes, explained that the first step to becoming fully patient centric is to measure the company in relation to the patient, ultimately understanding how the organization is positioned.1 For instance, has a company's branding overwhelmed the patient, even to the point of creating confusion in treatment instruction? "Is the organization's attention to branding an issue, and does a fixation on promoting the organization get in the way of prioritizing the patient? How can you elevate the patient experience?" mused Robinson at the conference. "Is your organization disconnected from the patient?" he asked further, urging companies to stop taking things like branding for granted. Ultimately, many organizations are focused on "brand-centricity not patient centricity," he cautioned.
In order to alter the current industry mindset so the patient ultimately benefits, an upheaval in organizational structure and everyday operations is warranted. At the event, Robinson called for a change in the culture of the industry — such that the entire supply chain is interrupted. "When you're trying to build a collaborative environment and change the culture — and be able to deliver on this — you can't do it with just the commercial organization or the medical affairs organization, it has to be research, commercial and the medical affairs all pushing together," noted Robinson.1 Speaking of an "ah-ha" research moment, which made him realize the organization could do better, he called for patient centricity in all facets of production. "Now target product profiles had an urgency to incorporate a patient focus, ensuring anything a patient touched made sense....Getting their input was also critically important, and we got their input by being able to sit down and talk to patients directly about what's important to them."1
Patient Centric at All Phases
To be truly effective, patient centricity must be incorporated into all phases of development. Patient centricity must be integrated into every area and aspect of the supply chain; it must be an all-encompassing system where patient needs come first, and this begins in drug discovery and research. Perhaps the trend in pharmaceuticals most compatible with the new era in patient centricity is precision medicine.2 The idea of tailored treatment reinforces the idea that a patient has been considered from start to finish — and there is no doubt that outcomes will also be improved as medicines become better targeted to meet the individual's needs. Precision medicine includes some of the most innovative tech taking over the industry, including genomic sequencing, biomarker research, bioinformatics and big data analysis.3
Precision medicine is offering the industry tremendous opportunity for more advanced and accurate outcomes; it will also contribute to cost savings. According to a research study that polled top industry executives, conducted by consumer insight firm PwC Strategy& (PwC), there is an almost unanimous push toward precision medicine throughout the industry.4 Of the global pharma leaders surveyed by PwC, 92% responded that they have identified precision medicine as an opportunity, while 84% have already added tackling precision medicine to their corporate agenda.
Precisely Patient Centric
Part of the motivation for applying precision medicine to the initial phases of drug development is the opportunity to cut spending. Respondents indicated a reduction in time-to-market and making R&D processes more efficient as drivers for furthering a precision medicine agenda within their organization or network. According to PwC's executive summary results, "even a conservative estimate puts the cost savings in drug development at 17 percent, leading to a potential annual savings of US $26 billion for the industry worldwide."4
In order to alter the current industry mindset so the patient ultimately benefits, an upheaval in organizational structure and everyday operations is warranted.
Poised for Precision Profit
The research and drug discovery sectors, in particular, stand to benefit from the trend toward precision medicine. Respondents identified areas along the value chain, including the identification of new drug targets (53%), improving effectiveness (42%), improved decision making (22%) and efficiency (18%) as advantages in implementing precision medicine early on.4 According to the survey, respondents pointed to the following areas as mechanisms by which precision medicine could improve drug development overall:
More accurate identification of new drug targets
Greater clarity regarding the target patient profile
More targeted clinical trials requiring smaller statistically valid pools of patients, leading to better trial outcomes and faster time-to-market
Greater likelihood of regulatory approval
More certain reimbursement and adoption of medicines
Longer market exclusivity
Over 75% of respondents felt that incorporating precision medicine into R&D would help reduce the average R&D cycle — which can last approximately 10 years — by roughly eight months, and one out of three respondents felt that a full one-year reduction was plausible. Global spending on R&D is about $150 billion worldwide — again, implementing precision medicine effectively could reduce that figure by $26 billion annually, or by $19 billion for the United States, Switzerland and the five largest countries in the European Union, where spending is the highest. Sales would no doubt also experience an upsurge, which is not factored in here.
Real World Value
Bringing patient centricity and R&D together would increase tangible real-world evidence (RWE). As pharma moves to a value-based medicine system, this would pacify payers, stakeholders and government, who are eager for positive results to confirm investment.3,5 Financial reimbursements are inextricably linked to proven RWE that a drug's outcome is positive, measured through clinical trials.5 However, an emphasis on RWE has also led to a decline in R&D spending — this is because, unless a treatment is known to be beneficial, it is met with risk aversion. This catch-22 could be solved by a patient-centric R&D model with an emphasis on increased RWE in data, which could, in turn, help spur investment in the strained sector.5 As one respondent to the PwC precision medicine study optimistically stated, "Demographics and innovation will lead to intensified cost containment pressure. Precision medicine is one promising way to fundamentally support the value story."4
Collaboration is Crucial
A potential opportunity to leverage RWE in trials is through partnerships with tech companies who have been able to scale-up successfully while focusing on customization.3 Leveraging the ability of tech giants, such as Amazon or Google, to identify patients and track their individual needs fits nicely with the goal of precision medicine. Relying on these data-centric organizations might be what is needed to reshape trials and diagnostic testing. For instance, a standardized blood test may be replaced with a more sophisticated diagnostic option that will screen for many abnormalities at once — as opposed to subjecting a patient to numerous tests.3 As Craig Venter, the scientist behind the Celera human genome sequencing endeavor and head of Human Longevity Inc., explains, this will shape our approach to medicine and data, linking them intricately together. "Medicine has been a clinical science, supported by data. Medicine is about to become a data science, supported by clinicians," he predicted.3
Challenges to Overcome
In spite of the obvious advantages of a transition to precision medicine starting from the earliest phases, there are quite a few barriers to entry to overcome before the tools needed are adapted. For many organization leaders, the lack of knowledge of data analytics has presented a tremendous issue, and they are looking for external partnerships to remedy this.4 To overcome a perceived lack of internal data capabilities, 87% of respondents have opted for "targeted collaborations beyond pharmaceutical firms" as a solution, with 65% looking to external experts to help break down the data. Other barriers to transition include "the uncertain legal and regulatory framework surrounding precision medicine, a limited ability to integrate data sources due to a lack of widely accepted standards and methods, and continuous regulatory oversight with rules that were written for a previous generation of healthcare and data."
Connecting in Clinical Trials
Perhaps the area where data most stands out in drug development is in relation to clinical trials. The National Cancer Institute and the Centers for Disease Control and Prevention rely on the following 4Ps model, where precision medicine is defined as "evidence based medicine," as follows:3
Predictive: Identifying disease early through greater use of prognostic tests and screening procedures.
Preventative: Intercepting the disease rather than tackling it once it becomes symptomatic – moving away from the "ambulance at the bottom of the cliff" approach to treating patients.
Personalized: Developing and choosing medicines that will change the patient experience from one of hope to one of certainty of response.
Participatory: Taking a modern view of the diverse stakeholders who play a role in patient care now and democratizing information so everyone can be informed.
The trends most apparent in this breakdown are the importance of data as a tool in precision medicine and of making testing more precise. A patient's history will also take precedence in a patient-centric approach to treatment. Data, such as a patient's genetics, health history, diet, lifestyle and even their microbiome, will be incorporated to predict potential outcomes.3
Patient centricity in clinical trials is achieved first and foremost by communicating with the patient, understanding their motivation for undergoing a trial and demonstrating sensitivity to this.3 Clinical research organizations can implement patient centricity by prioritizing patient goals. Companies are looking to reshape their approach to trials by considering all aspects, including patient comfort.6 In trials, patient centricity is distinguished from patient engagement. According to Forte Research, "patient engagement is a participant's activity during the trial, where patient centricity is really a frame of mind held by site leadership and operations to provide the best possible patient care throughout a protocol."6 Indeed, patients respond well when they feel they have been provided for throughout — one way this plays out is through transportation to and from trials. Doctor recommendations can also make a tremendous difference. A study by Tufts University found that 72% of patients would be more willing to participate in a trial if a doctor they trusted recommended it to them.6
Looking Ahead in Patient Centricity
The future of patient-centric medicine is bright. It will undoubtedly touch all aspects of patient care and health treatments and outcomes, with data being a major component of diagnostic testing, clinical trials and R&D. With specific patient data informing drug reactions, it will not be long before a one-size-fits-all approach to medicine is effectively replaced. Instead, analysis on what is right for an individual will revolutionize the way patients are treated, with medicine becoming more targeted and efficacious. Organizations will be able to identify therapies based on effectiveness analytics, while clinical trials become more targeted. This will lead to faster drug development and a decrease in unnecessary R&D spending, for overall improved patient outcomes.
Read Part 2: Remember the User – Incorporating Patient Centricity into Drug Design
Read Part 3: The Impact of Patients as Consumers: New Fill/Finish and Packaging Solutions
"eyeforpharma Philadelphia 2018." eyeforpharma. n.d. Web.
Harsha, Rajasimha. "Patient centricity in the era of data-driven value-based precision medicine." Journal of Pharmacogenomics & Pharmacoproteomics. 8: 4(Suppl) (2017).
Precision Medicine Starts Here. Blue Latitude Health. 18 May 2018. Web.
Danner, Stephan, Thomas Solbach, Mark Ludwig. "Capitalizing on precision medicine: How pharmaceutical firms can shape the future of healthcare." PwC Strategy&. 24 Aug. 2017. Web.
Rönicke, Volker, Michael Ruhl, Thomas Solbach. "Revitalizing pharmaceutical R&D: The value of real world evidence." PwC Strategy&. 2 Mar. 2015. Web.
Mel Johnson. "5 Takeaways for More Patient-Centric Clinical Trials." Forte. 21 Jun. 2017. Web.
David Alvaro, Ph.D.
David is Scientific Editorial Director for That's Nice and the Pharma's Almanac content enterprise, responsible for directing and generating industry, scientific and research-based content, including client-owned strategic content. Before joining That's Nice, David served as a scientific editor for the multidisciplinary scientific journal Annals of the New York Academy of Sciences. He received a B.A. in Biology from New York University and a Ph.D. in Genetics and Development from Columbia University.
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Cynthia A. Challener, Ph.D.
Emilie Branch
The Outsourcing Issue:
Patient Centricity and the Pharmaceutical Supply Chain: An Evolving Dynamic
Remember the User – Incorporating Patient Centricity into Drug Design
The Impact of Patients as Consumers: New Fill/Finish and Packaging Solutions
The Outsourcing Issue Feature:
Part 1: Pursuing Patient Centricity from Start to Finish
Part 2: Remember the User – Incorporating Patient Centricity into Drug Design
Part 3: The Impact of Patients as Consumers: New Fill/Finish and Packaging Solutions


text:
Jennifer Smith, née le  à Lisbonne, est une chanteuse lyrique, soprano.

Jennifer Smith, diplômée du conservatoire de musique de Lisbonne, s'est installée à Londres pour des études à la fondation Gulbenkian.
Elle a chanté à l'opéra et en récital, entre autres avec Les Arts florissants et les English Baroque Soloists.
C'est avec Jean-François Paillard qu'elle obtient ses grands prix du disque, dans le Te Deum de Lully et Les Indes galantes de Rameau produits pour la firme Erato.

Son répertoire s'étend de la musique baroque à la période moderne. Par sa capacité à chanter en portugais, elle est spécialiste de la musique du Portugal et du Brésil.
Elle a enseigné le chant au Royal College of Music. En raison de son nom et de sa résidence à Londres, elle est parfois considérée comme une chanteuse anglaise.

Discographie : exemples
 Jean Baptiste Lully Grand Te Deum avec Jean-François Paillard, Erato. Grand prix du disque lyrique français.
 Gabriel Fauré : Les mélodies avec Graham Johnson en 4 CD (The complete songs, Hyperion, 2005)
 Olivier Greif : Chants de l'âme avec l'auteur au piano (Triton, 1999)
 Georg Friedrich Haendel : Il trionfo del Tempo e del Disinganno avec Les Musiciens du Louvre, dir. Marc Minkowski (Erato, 1988)
 Monteverdi : L'Orfeo avec London Baroque, dir. Charles Medlam (EMI, 1983 ou 1993)
 Henry Purcell : King Arthur avec English Baroque Soloists et Monteverdi Choir, dir. John Eliot Gardiner (Erato, 1983)
 Jean-Philippe Rameau : Les Boréades avec English Baroque Soloists et Monteverdi Choir, dir. John Eliot Gardiner (Erato, 1982)
 Jean-Philippe Rameau : Platée avec Les Musiciens du Louvre et Ensemble vocal Françoise Herr, dir. Marc Minkowski (Erato, 1990, ).

Source

Liens externes
 Biographie et discographie chez Hyperion

Naissance en juillet 1945
Naissance à Lisbonne
Chanteuse portugaise d'opéra
Soprano portugaise

redpajama_set_name: RedPajamaWikipedia


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text:
#include "bedFile.h"
#include "common.h"
#include "hts.h"
#include "variants_annotator.h"
#include <algorithm>
#include <cstdlib>
#include <stdexcept>

//Usage statement for this tool
int VariantsAnnotator::usage(ostream& out) {
    out << "\nUsage:\t\t" << "regtools variants annotate [options] variants.vcf annotations.gtf";
    out << "\n\t\t" << "-e INT\tMaximum distance from the start/end of an exon "
                       "\n\t\t\tto annotate a variant as relevant to splicing, the variant "
                       "\n\t\t\tis in exonic space, i.e a coding variant. [3]";
    out << "\n\t\t" << "-i INT\tMaximum distance from the start/end of an exon "
                       "\n\t\t\tto annotate a variant as relevant to splicing, the variant "
                       "\n\t\t\tis in intronic space. [2]";
    out << "\n\t\t" << "-I\tAnnotate variants in intronic space within a transcript(not to be used with -i).";
    out << "\n\t\t" << "-E\tAnnotate variants in exonic space within a transcript(not to be used with -e).";
    out << "\n\t\t" << "-o\tFile to write output to. [STDOUT]";
    out << "\n\t\t" << "-S\tDon't skip single exon transcripts.";
    out << "\n";
    return 0;
}

//Parse command line options
int VariantsAnnotator::parse_options(int argc, char *argv[]) {
    optind = 1; //Reset before parsing again.
    int16_t c;
    stringstream help_ss;
    while((c = getopt(argc, argv, "e:Ehi:Io:S")) != -1) {
        switch(c) {
            case 'i':
                intronic_min_distance_ = atoi(optarg);
                break;
            case 'e':
                exonic_min_distance_ = atoi(optarg);
                break;
            case 'I':
                all_intronic_space_ = true;
                break;
            case 'E':
                all_exonic_space_ = true;
                break;
            case 'o':
                vcf_out_ = string(optarg);
                break;
            case 'S':
                skip_single_exon_genes_ = false;
                break;
            case 'h':
                usage(help_ss);
                throw common::cmdline_help_exception(help_ss.str());
            default:
                usage(std::cout);
                throw runtime_error("\nError parsing inputs!(1)\n");
        }
    }
    if(argc - optind >= 2) {
        vcf_ = string(argv[optind++]);
        gtffile_ = string(argv[optind++]);
        gtf_.set_gtffile(gtffile_);
    }
    if(optind < argc ||
       vcf_ == "NA" ||
       gtffile_ == "NA") {
        usage(std::cout);
        throw runtime_error("\nError parsing inputs!(2)\n");
    }
    cerr << "\nVariant file: " << vcf_;
    cerr << "\nGTF file: " << gtffile_;
    cerr << "\nOutput vcf file: " << vcf_out_;
    if(!all_intronic_space_) {
        cerr << "\nIntronic min distance: " << intronic_min_distance_;
    }
    if(!all_exonic_space_) {
        cerr << "\nExonic min distance: " << exonic_min_distance_;
    }
    if(!skip_single_exon_genes_)
        cerr << "\nNot skipping single exon genes.";
    if(vcf_out_ != "NA")
        cerr << "\nOutput file: " << vcf_out_;
    cerr << endl;
    return 0;
}

//Read gtf info into gtf_
void VariantsAnnotator::load_gtf() {
    gtf_.load();
}

//Open input VCF file
void VariantsAnnotator::open_vcf_in() {
    vcf_fh_in_ = bcf_open(vcf_.c_str(), "r");
    if(vcf_fh_in_ == NULL) {
        throw std::runtime_error("Unable to open file.");
    }
    vcf_header_in_ = bcf_hdr_read(vcf_fh_in_);
    if(vcf_header_in_ == NULL) {
        throw std::runtime_error("Unable to read header.");
    }
}

//Open output VCF file
void VariantsAnnotator::open_vcf_out() {
    vcf_fh_out_ =  hts_open(vcf_out_ == "NA" ? "-" : vcf_out_.c_str(),
                            "w");
    if(vcf_fh_out_ == NULL) {
        throw runtime_error("Unable to open output VCF file");
    }
    vcf_header_out_ = bcf_hdr_dup(vcf_header_in_);
    bcf_hdr_append(vcf_header_out_,
                   "##INFO=<ID=genes,Number=1,Type=String,"
                   "Description=\"The Variant falls in the splice "
                   "region of these genes\"");
    bcf_hdr_append(vcf_header_out_,
                   "##INFO=<ID=transcripts,Number=1,Type=String,"
                   "Description=\"The Variant falls in the splice "
                   "region of these transcripts\"");
    bcf_hdr_append(vcf_header_out_,
                   "##INFO=<ID=distances,Number=1,Type=String,"
                   "Description=\"Vector of Min(Distance from start/end of exon in the transcript.)\"");
    bcf_hdr_append(vcf_header_out_,
                   "##INFO=<ID=annotations,Number=1,Type=String,"
                   "Description=\"Does the variant fall in exonic/intronic splicing "
                   "related space in the transcript.\"");
    bcf_hdr_sync(vcf_header_out_);
    bcf_hdr_write(vcf_fh_out_, vcf_header_out_);
}

//Free relevant pointers
void VariantsAnnotator::cleanup() {
    if(vcf_header_in_)
        bcf_hdr_destroy(vcf_header_in_);
    if(vcf_fh_in_)
        bcf_close(vcf_fh_in_);
    if(vcf_header_out_)
        bcf_hdr_destroy(vcf_header_out_);
    if(vcf_fh_out_)
        bcf_close(vcf_fh_out_);
    if(vcf_record_)
        bcf_destroy(vcf_record_);
}

//Set limits on + strand
inline
void VariantsAnnotator::set_variant_cis_effect_limits_ps(const vector<BED>& exons,
                                                      AnnotatedVariant& variant,
                                                      uint32_t i) {
    //Check if the cis effect limits have increased.
    if(i != 0) {
        if(exons[i-1].start < variant.cis_effect_start) {
            variant.cis_effect_start = exons[i-1].start;
        }
    } else {
        if(exons[0].start < variant.cis_effect_start) {
            variant.cis_effect_start = exons[0].start;
        }
    }
    if(i != exons.size() - 1) {
        if(exons[i+1].end > variant.cis_effect_end) {
            variant.cis_effect_end = exons[i+1].end;
        }
    } else {
        if(exons[exons.size() - 1].end > variant.cis_effect_end) {
            variant.cis_effect_end = exons[exons.size() - 1].end;
        }
    }
    return;
}

//Set limits on + strand for exonic/intronic case
inline
void VariantsAnnotator::set_variant_cis_effect_limits_exonic_intronic_ps(const vector<BED>& exons,
                                                      AnnotatedVariant& variant) {
    variant.cis_effect_start = exons[0].start;
    variant.cis_effect_end = exons[exons.size() - 1].end;
}

//Set limits on - strand for exonic/intronic case
inline
void VariantsAnnotator::set_variant_cis_effect_limits_exonic_intronic_ns(const vector<BED>& exons,
                                                      AnnotatedVariant& variant) {
    variant.cis_effect_end = exons[0].end;
    variant.cis_effect_start = exons[exons.size() - 1].start;
}

//Set limits on - strand
inline
void VariantsAnnotator::set_variant_cis_effect_limits_ns(const vector<BED>& exons,
                                                      AnnotatedVariant& variant,
                                                      uint32_t i) {
    if(i != 0) {
        //Check if the cis effect limits have increased.
        if(exons[i-1].end > variant.cis_effect_end) {
            variant.cis_effect_end = exons[i-1].end;
        }
    } else {
        if(exons[0].end > variant.cis_effect_end) {
            variant.cis_effect_end = exons[0].end;
        }
    }
    if(i != exons.size() -1) {
        if(exons[i+1].start < variant.cis_effect_start) {
            variant.cis_effect_start = exons[i+1].start;
        }
    } else {
        if(exons[exons.size() - 1].start < variant.cis_effect_start) {
            variant.cis_effect_start = exons[exons.size() - 1].start;
        }
    }
    return;
}

//Get the coordinates which limit the effect of this variant.
//The cis-splice-effects command uses these fields to pull out
//junctions which might be related to the presence of this variant.
//This is set to the nearest acceptor and donor of the neigboring
//exons. The calculation will vary according to the strand of this
//transcript.
inline
void VariantsAnnotator::set_variant_cis_effect_limits(const vector<BED>& exons,
                                                      AnnotatedVariant& variant,
                                                      uint32_t i) {
    string transcript_strand = exons[0].strand;
    if(transcript_strand == "+") {
        set_variant_cis_effect_limits_ps(exons, variant, i);
        return;
    }
    if(transcript_strand == "-") {
        set_variant_cis_effect_limits_ns(exons, variant, i);
        return;
    }
}

//Get the coordinates which limit the effect of this variant.
//The cis-splice-effects command uses these fields to pull out
//junctions which might be related to the presence of this variant.
//This is set to the nearest acceptor and donor of the neigboring
//exons. The calculation will vary according to the strand of this
//transcript.
//This is for exonic/intronic variants - not necessarily in the splice region
inline
void VariantsAnnotator::set_variant_cis_effect_limits_exonic_intronic(const vector<BED>& exons,
                                                      AnnotatedVariant& variant) {
    string transcript_strand = exons[0].strand;
    if(transcript_strand == "+") {
        set_variant_cis_effect_limits_exonic_intronic_ps(exons, variant);
        return;
    }
    if(transcript_strand == "-") {
        set_variant_cis_effect_limits_exonic_intronic_ns(exons, variant);
        return;
    }
}

//Overlap splice region in the negative strand
void VariantsAnnotator::get_variant_overlaps_spliceregion_ns(const vector<BED>& exons,
                                                      AnnotatedVariant& variant) {
    variant.score = "-1";
    variant.annotation = "non_splice_region";
    //check if variant inside transcript coords for negative strand
    if(exons[exons.size() - 1].start > variant.end ||
       exons[0].end < variant.end) {
        return;
    }
    for(uint32_t i = 0; i < exons.size(); i++) {
        if(all_exonic_space_) {
            //The exon start and end are in 1-based
            if(variant.end >= exons[i].start && variant.end <= exons[i].end) {
                variant.score =  common::num_to_str(min(variant.end - exons[i].start,
                                                        exons[i].end - variant.end));
                variant.annotation = "exonic";
                set_variant_cis_effect_limits_exonic_intronic(exons, variant);
                return;
            }
        }
        if(all_intronic_space_) {
            //The exon start and end are in 1-based
            if(i != exons.size() - 1 && variant.end < exons[i].start && variant.end > exons[i+1].end) {
                variant.score =  common::num_to_str(min(variant.end - exons[i+1].end,
                                                        exons[i].start - variant.end));
                variant.annotation = "intronic";
                set_variant_cis_effect_limits_exonic_intronic(exons, variant);
                return;
            }
        }
        {
            //the rest of the exons are outside the junction - ns
            if(exons[i].end + intronic_min_distance_ < variant.end) {
                return;
            }
            //exonic near start and not last exon
            if(i != exons.size() - 1 && variant.end >= exons[i].start &&
               variant.end <= exons[i].end &&
               variant.end <= exons[i].start + exonic_min_distance_) {
                variant.score =  common::num_to_str(min(variant.end - exons[i].start,
                                                        exons[i].end - variant.end));
                variant.annotation = "splicing_exonic";
                set_variant_cis_effect_limits(exons, variant, i);
                return;
            }
            //intronic near start (make sure not first/last exon.)
            //make sure this isn't exonic in next exon
            if(variant.end < exons[i].start &&
            variant.end >= exons[i].start - intronic_min_distance_ &&
            i != exons.size() - 1 && variant.end > exons[i+1].end) {
                variant.score =  common::num_to_str(min(variant.end - exons[i+1].end,
                                                        exons[i].start - variant.end));
                variant.annotation = "splicing_intronic";
                set_variant_cis_effect_limits(exons, variant, i);
                return;
            }
            //exonic near end and not first exon
            if(i != 0 &&
               variant.end <= exons[i].end &&
               variant.end >= exons[i].start &&
               variant.end >= exons[i].end - exonic_min_distance_) {
                variant.score =  common::num_to_str(min(variant.end - exons[i].start,
                                                        exons[i].end - variant.end));
                variant.annotation = "splicing_exonic";
                set_variant_cis_effect_limits(exons, variant, i);
                return;
            }
            //intronic near end (make sure not first/last exon.)
            //make sure this isn't exonic in prev exon
            if(variant.end > exons[i].end &&
            variant.end <= exons[i].end + intronic_min_distance_ &&
            i != 0 && variant.end < exons[i-1].start) {
                variant.score =  common::num_to_str(min(variant.end - exons[i].end,
                                                        exons[i-1].start - variant.end));
                variant.annotation = "splicing_intronic";
                set_variant_cis_effect_limits(exons, variant, i);
                return;
            }
        }
    }
    return;
}

//Overlap splice region in the positive strand
void VariantsAnnotator::get_variant_overlaps_spliceregion_ps(const vector<BED>& exons,
                                                             AnnotatedVariant& variant) {
    variant.score = "-1";
    variant.annotation = "non_splice_region";
    //check if variant inside transcript coords for positive strand
    if(exons[0].start > variant.end ||
       exons[exons.size() - 1].end < variant.end) {
        return;
    }
    for(uint32_t i = 0; i < exons.size(); i++) {
        if(all_exonic_space_) {
            //The exon start and end are in 1-based
            if(variant.end >= exons[i].start &&
               variant.end <= exons[i].end) {
                variant.score =  common::num_to_str(min(variant.end - exons[i].start,
                                                        exons[i].end - variant.end));
                variant.annotation = "exonic";
                set_variant_cis_effect_limits_exonic_intronic(exons, variant);
                return;
            }
        }
        if(all_intronic_space_) {
            //The exon start and end are in 1-based
            if(i != exons.size() - 1 &&
               variant.end > exons[i].end && variant.end < exons[i+1].start) {
                variant.score =  common::num_to_str(min(variant.end - exons[i].end,
                                                        exons[i+1].start - variant.end));
                variant.annotation = "intronic";
                set_variant_cis_effect_limits_exonic_intronic(exons, variant);
                return;
            }
        }
        {
            //the rest of the exons are outside the junction - ps
            if(exons[i].start - intronic_min_distance_ > variant.end) {
                return;
            }
            //exonic near start and not first exon
            if(i != 0 &&
               variant.end >= exons[i].start &&
               variant.end <= exons[i].end &&
               variant.end <= exons[i].start + exonic_min_distance_) {
                variant.score =  common::num_to_str(min(variant.end - exons[i].start,
                                                        exons[i].end - variant.end));
                variant.annotation = "splicing_exonic";
                set_variant_cis_effect_limits(exons, variant, i);
                return;
            }
            //intronic near start (make sure not first/last exon.)
            //make sure this isn't exonic in prev exon
            if(variant.end < exons[i].start &&
            variant.end >= exons[i].start - intronic_min_distance_ &&
            i != 0 && variant.end > exons[i-1].end) {
                variant.score =  common::num_to_str(min(variant.end - exons[i-1].end,
                                                        exons[i].start - variant.end));
                variant.annotation = "splicing_intronic";
                set_variant_cis_effect_limits(exons, variant, i);
                return;
            }
            //exonic near end
            if(i != exons.size() - 1 &&
               variant.end <= exons[i].end &&
               variant.end >= exons[i].start &&
               variant.end >= exons[i].end - exonic_min_distance_) {
                variant.score =  common::num_to_str(min(variant.end - exons[i].start,
                                                        exons[i].end - variant.end));
                variant.annotation = "splicing_exonic";
                set_variant_cis_effect_limits(exons, variant, i);
                return;
            }
            //intronic near end (make sure not first/last exon.)
            //make sure this isn't exonic in next exon
            if(variant.end > exons[i].end &&
            variant.end <= exons[i].end + intronic_min_distance_ &&
            i != exons.size() - 1 && variant.end < exons[i+1].start) {
                variant.score =  common::num_to_str(min(variant.end - exons[i].end,
                                                        exons[i+1].start - variant.end));
                variant.annotation = "splicing_intronic";
                set_variant_cis_effect_limits(exons, variant, i);
                return;
            }
        }
    }
    return;
}

//Given a transcript ID and variant position,
//check if the variant is in a splice relevant region
//relevance depends on the user params
//intronic_min_distance_ and exonic_min_distance_
//The zero-based arithmetic is always fun.
//The variant object is one-based.
//GTF i.e the exon is one based
void VariantsAnnotator::get_variant_overlaps_spliceregion(const vector<BED>& exons,
                                                      AnnotatedVariant& variant) {
    string transcript_strand = exons[0].strand;
    if(transcript_strand == "+") {
        get_variant_overlaps_spliceregion_ps(exons, variant);
    } else if (transcript_strand == "-") {
        get_variant_overlaps_spliceregion_ns(exons, variant);
    } else {
        throw runtime_error("Unknown strand " + transcript_strand);
    }
    return;
}

//Annotate one line of a VCF
//The line to be annotated is in vcf_record_
AnnotatedVariant VariantsAnnotator::annotate_record_with_transcripts() {
    string overlapping_genes = "NA",
           overlapping_transcripts = "NA",
           overlapping_distances = "NA",
           annotations = "NA";
    set<string> unique_genes;
    string chr = std::string(bcf_hdr_id2name(vcf_header_in_, vcf_record_->rid));
    AnnotatedVariant variant(chr, vcf_record_->pos, (vcf_record_->pos) + 1);
    //While calculating BINs, incorporate intronic_distance since transcripts
    //which lie within that distance will be relevant.
    BIN start_bin = ((vcf_record_->pos - intronic_min_distance_) >> _binFirstShift);
    BIN end_bin = ((vcf_record_->pos + intronic_min_distance_ ) >> _binFirstShift);
    //Iterate over all BINs this variant could fall under
    for (BINLEVEL i = 0; i < _binLevels; ++i) {
        BIN offset = _binOffsetsExtended[i];
        for (BIN b = (start_bin + offset); b <= (end_bin + offset); ++b) {
            vector<string> transcripts = gtf_.transcripts_from_bin(chr.c_str(), b);
            for(std::size_t i = 0; i < transcripts.size(); i++) {
                const vector<BED> & exons =
                    gtf_.get_exons_from_transcript(transcripts[i]);
                if(!exons.size()) {
                    throw runtime_error("Unexpected error. No exons for transcript "
                            + transcripts[i]);
                }
                //Skip single exon genes
                if(skip_single_exon_genes_ && exons.size() == 1) {
                    continue;
                }
                //Use a AnnotatedVariant object to hold the result
                get_variant_overlaps_spliceregion(exons, variant);
                if(variant.annotation != "non_splice_region") {
                    string gene_id = gtf_.get_gene_from_transcript(transcripts[i]);
                    //Use sign to encode intronic/exonic
                    string annotation = variant.annotation;
                    string dist_str = variant.score;
                    //Add gene only once for multiple transcripts of the same gene.
                    if(overlapping_transcripts != "NA") {
                        //Check if this gene is new
                        if(unique_genes.find(gene_id) == unique_genes.end()) {
                            overlapping_genes += "," + gene_id;
                            unique_genes.insert(gene_id);
                        }
                        overlapping_distances += "," + dist_str;
                        overlapping_transcripts += "," + transcripts[i];
                        annotations += "," + annotation;
                    } else {
                        overlapping_genes = gene_id;
                        overlapping_distances = dist_str;
                        overlapping_transcripts = transcripts[i];
                        unique_genes.insert(gene_id);
                        annotations = annotation;
                    }
                }
            }
        }
        start_bin >>= _binNextShift;
        end_bin >>= _binNextShift;
    }
    variant.annotation = annotations;
    variant.overlapping_genes = overlapping_genes;
    variant.overlapping_transcripts = overlapping_transcripts;
    variant.overlapping_distances = overlapping_distances;
    return variant;
}

//Write annotation output
void VariantsAnnotator::write_annotation_output(const AnnotatedVariant &v1) {
    if(bcf_update_info_string(vcf_header_out_, vcf_record_,
                              "genes", v1.overlapping_genes.c_str()) < 0 ||
       bcf_update_info_string(vcf_header_out_, vcf_record_,
                              "transcripts", v1.overlapping_transcripts.c_str()) < 0 ||
       bcf_update_info_string(vcf_header_out_, vcf_record_,
                              "distances", v1.overlapping_distances.c_str()) < 0 ||
       bcf_update_info_string(vcf_header_out_, vcf_record_,
                              "annotations", v1.annotation.c_str()) < 0) {
        throw runtime_error("Unable to update info string");
    }
    bcf_write(vcf_fh_out_, vcf_header_out_, vcf_record_);
}

//Read in next record
bool VariantsAnnotator::read_next_record() {
    return (bcf_read(vcf_fh_in_, vcf_header_in_, vcf_record_) == 0);
}

//Heavylifting happens here.
void VariantsAnnotator::annotate_vcf() {
    load_gtf();
    open_vcf_in();
    open_vcf_out();
    while(read_next_record()) {
        AnnotatedVariant v1 = annotate_record_with_transcripts();
        write_annotation_output(v1);
    }
    //The close happens in the destructor - see cleanup()
}

redpajama_set_name: RedPajamaGithub


text:
TVA Announces New Sequoyah Site Vice President
SODDY-DAISY, Tenn. - The Tennessee Valley Authority announced today that Christopher Schwarz, currently vice president of corporate operations at Public Service Enterprise Group Nuclear, has been named the new site vice president for its Sequoyah nuclear plant. Current site VP John Carlin has announced his retirement at the end of the year.
"John has been a respected leader in TVA Nuclear and had a strong impact on the improved performance seen at Sequoyah during his tenure," said Joe Grimes, TVA Chief Nuclear Officer.
"We are fortunate to find another exceptional leader in Chris, who can step in to continue Sequoyah's focus on achieving and sustaining top industry performance."
With a nuclear background spanning 41 years, Schwarz has held a number of senior leadership positions, including site vice president of both the Arkansas Nuclear One and Palisades nuclear stations, vice president of operations support for Entergy's northeast nuclear sites and site director for Dominion's Millstone nuclear plant. A U.S. Navy veteran, he holds an engineering degree from Widener University.
Schwarz will begin his new role at Sequoyah on Nov. 16 to allow for a seamless leadership transition at the site.

redpajama_set_name: RedPajamaCommonCrawl


A Press Release is a short, compelling news story directed at members of the news media for the purpose of announcing something ostensibly newsworthy and sent to targeted members. The goal of a press release is to pique the interest of a journalist or publication. The press release should contain all the essential information (who? what? where? when? how? and most importantly why?) for the journalist to easily produce his own story.
A Press Release written in text can also have included a video, image(s), Logo, Audio and even your Website Link and your Phone Number and Link to your Website.
Some Press Release submission can be free to paid and prices vary depending on demographics. It is best to have a budget set aside and to at least send one out at least once a month.
A Press Release can make a huge impact within the Search Engines as well getting your company on TV, such as in the news, if the story is new and fresh. Even if you are just looking to get a new product on the market you added to a shopping cart can increase your Organic listings. You can even announce something as simple as you hired a new employee and talk about how your company is growing.
Below is a small list of just some of the places / websites your Press Release will be posted. The below list covers most of the United States.


Susan Sarandon brought her sassy son Miles Robbins to the world premiere of 'Zoolander 2'in NYC. His outfit sure is interesting. What is that? A stuffed animal embroidered baby blue blazer with a tunic and tights??? Well. Do you likey?
Justin Theroux also came through on the carpet in character. He looks like Riff Raff's rastafarian wannabee cousin or something.
Ben Stiller's son Quinlin was stunting like his daddy with the Blue Steel pose too!


1090 Montgomery Rd , Altamonte Springs, Fl 32714 Order Papa Joe's Pizza - Altamonte (Catering) quickly and easily online for delivery. iCrave Delivery offers delivery from the best restaurants in the Altamonte Springs area straight to your office, hotel, or home!
*****Catering Orders require, at least, 24 hours notice***** Featuring premium cold cuts by boars head 1 foot serves 5-6 people, served paltter style with lettuce, tomatoes, onions & dressing.


text:
Electro House, Music
We AM & Sheezan – Don't Know Me
One of India's fastest rising producers, Sheezan is back with his latest single 'Don't Know Me' alongside Swiss duo We AM. With both acts' last few productions boasting a more Electro-House influence, their latest single takes a stride down tribal house lane. Following the standard 30-second intro, the track immediately enters the build-up and wastes no time in moving towards the drop. At
Tiësto delivers phenomenal headline set at Creamfields Steel Yard
Few artists in the electronic music industry have accumulated as much widespread acclaim for their talents as Tiësto. Having released countless global hits as well as many triumphant albums, the Dutch star has continued to be a dominant force in the industry throughout his years as a musician. As undoubtedly one of the UK crowd's favourite DJs, it comes as
Martin Garrix returns to ADE 2018 with two shows
For any electronic music lover, whether you be a producer, DJ, or fan, Amsterdam Dance Event has everything you could possibly ask for. With conferences led by high-end figures in the scene, events ran by some of the biggest and best DJs and companies, meet and greets, and so much more, the week long event has it all. Now, as
#Ibiza, Featured, News
'Disturbing Ibiza' announces full line-ups for 2018 residency
Returning after a sensational 2017, Disturbing Ibiza is back with a Summer packed full of disruption from some of the biggest artists and hottest new names from around the world. Joining Tinie Tempah and DJ Charlesy will be UK rap sensation Stefflon Don, as well as Giggs, Lethal Bizzle, Bugzy Malone, and Wiz Khalifa. Every Wednesday for 14 weeks, fans can
Featured, Live Sets, Mixes
REZZ releases full bass filled EDC Las Vegas 2018 live set
2018's unrivaled Queen of Bass has officially released her energy infused EDC Las Vegas live set. With trippy stage production that compliments her eerie and distorted tunes coupled with a knack for continually captivating audiences around the world, EDC's Las Vegas Motor Speedway is the perfect home for a Rezz show. The dark and ambient vibes that Rezz is able to
Events, Featured, Industry, News
Avicii's 'Waiting For Love' turns 3 years old today
Over a month after the Swedish legend Avicii's passing, his music has seen such a monumental resurgence. With plenty of hits and a back catalog littered with dance classics including 'Seek Bromance', a tune that released before he went by the moniker "Avicii", 'Levels', 'Hey Brother', 'The Days/The Nights EP', 'Waiting For Love' and so many more, there's never a way
Bass House, Dubstep, Featured, Music, News
Madeon celebrates 24th birthday with special 'Shelter Evil Edit'
Madeon turning 24 years old is a true sign that time is flying by. For the young French producer, making tracks like 'Icarus' and his famed 'Pop Culture' mashup kick started his career, turning him into the huge producer that he is today, taking on world tours and every festival known to man. His journey to success is remarkable, but
Editorials, Featured
Steve Angello's emotional 'Children Of The Wild' turns 3 years old
After all the massive hype around Swedish House Mafia's comeback this year, including a probable gig in New York in 2019, you can easily forget that all three members of SHM are also amazing in producing solo tracks. Axwell's 'In My Mind' and Sebastian Ingrosso's 'Reload' are perfect examples for that. One of Steve Angello's most renowned tracks 'Children Of The Wild' turns 3 years old today! After the massive success of Steve's
Rita Ora opens up about working with the legendary Avicii
The passing of legendary music producer Avicii, also known as Tim Bergling, is still being felt around the electronic dance world as it still comes to terms with the loss of a true icon. With his music touching millions of fans around the world, Avicii also touched the hearts of many of his fellow artists in the music industry. As
Axwell's classic tune 'Center of the Universe' turns 5 years old
With the reunion of Swedish House Mafia, Axwell, Sebastian Ingrosso, and Steve Angello have all found their way back together, as confirmation was just given by Axwell regarding a 2019 tour. Although the three dominated the scene together as Swedish House Mafia, individually each artist also provided a number of iconic anthems. Now, a classic tune that debuted right around
Editorials, Events, Featured, News
Above & Beyond deliver sensational London performance at Creamfields Steel Yard
When British trio Above & Beyond played London's iconic O2 Arena in November, no sooner had the final flickers of the group's final song echoed around the dome, before a bright light illuminated the arena, shining from the LED screens behind the now-departing trance triplets. Teasing their next London date, the poster, clad in the spherical primary colours of the 'Common
#Ibiza, Events, Featured, Industry
IMS Ibiza 2018 Recap
The International Music Summit (IMS) in Ibiza stands tall as one of the most anticipated music industry weekends of the year. This year's exciting edition has just came to an end and We Rave You was there to witness this energy packed event and gain an insight on the new trends within the music industry. We enjoyed the Ibiza sunshine
Skrillex seen in studio with Boys Noize. Are Dog Blood back?
Could 2018 be the year of comebacks? After the Swedish House Mafia reunion at Ultra Music Festival 2018, there are hints that Dog Blood could be back soon as well. Sonny John Moore, better known as Skrillex has no doubt been one of the most influential and innovative artists of this generation, constantly pushing the barriers of electronic music and building an incredible catalogue of successful releases
MR.BLACK – Lights
In a day and age where a label's might and a producer's worth are also determined by the appeasement of their fans and followers, Hardwell's Revealed Recordings and Israeli production virtuoso and DJ MR.BLACK are not ones to forget about giving back to the fans. The Israeli producer is back on track with a thumping track titled 'Lights' which is
Bass House, Music
CastNowski – Machine-Made Music [EP]
Quebec-born artist CastNowski has been driving his bass house signature sound to the forefront in recent months, and continues on this positive momentum with the release of his latest EP "Machine-Made Music". Starting as an unknown artist in 2015, he's rapidly becoming a staple of the bass/G-House genre with consistent support from some of the world's biggest artists, including Oliver Heldens,


Haven't found the right listing? There are 55 other Tree Service in Sarasota FL. Click here!
Lamb Tree Care can be found at Sarasota FL in . The following is offered: Tree Service . In Sarasota FL there are 55 other Tree Service. An overview can be found here.


Rusty accept the 1v1 challenge plz kthx!!
Rager i have my entire install on acme downloads i believe.
I was only give 3 times on the same evening. I cannot guarantee being back in town. It is likely I will have to forfeit.
didn't get back at a reasonable hour and was incredibly exhausted. I'll submit a win for you, it's not worth rescheduling since the results would be pretty predictable.
Come on...make him work for it! RJ the hole game...he loves that.


Command Timeout - If the server receives a command that sends large amounts of data but the data stops coming in for this number of minutes, the command will be aborted. By default, the command times out after 5 minutes.
Max POP Retrieval Threads - SmarterMail is multi-threaded, meaning it can do more than one thing at a time. This setting is for the maximum number of threads you want SmarterMail to work on concurrently for retrieving mail using the POP protocol. By default, the maximum number of POP retrieval threads is 10.
SSL - Check this box to enable autodiscover to use SSL. NOTE: Autodiscover generally requires the use of SSL, especially when used with Microsoft Outlook.
Command Timeout - If the server receives a command that sends large amounts of data but the data stops coming in for this number of minutes, the command will be aborted. By default, the command times out after 15 minutes.
IMAP Retrieval Interval - The frequency by which SmarterMail checks for new IMAP messages. By default, the IMAP retrieval interval is 10 minutes.
Allow Relay - If you are concerned about spam mailers using the relay function to send mail through your server or do not want any other mail server to use your SMTP server as a gateway, set this to Nobody (recommended). However, you can set the type of relays you will allow, should you so desire.
Command Timeout - If the server receives a command that sends large amounts of data but the data stops coming in for this number of seconds, the command will be aborted. By default, the command times out after 120 seconds.
Max Bad Recipients - At times, spammers will hammer a domain with a dictionary harvesting attack. This means that software is used to send messages to many of the most common mailbox addresses (e.g., admin, user, contact, etc.) or username variations (e.g., alan@, alana@, alanb@, etc.) in order to find valid email addresses. Setting the max bad recipients means that after this many bad recipients (those that don't exist for the domain), the SMTP session will be terminated. This setting allows you to better protect yourself against email harvesting attacks. A value of 20 is recommended in most cases.
Append Received Line - Select the option for appending the received line for all messages, only for SMTP Authenticated messages or for no messages at all.
Require Auth Match - Select this to force a user's From: address to match their SMTP authenticated address, either by matching the entire email address or by matching just the domain - or not requiring it at all. This setting helps keep senders from spoofing email addresses through email clients.
Max Messages Per Session - The maximum number of messages that can be sent in one session. This is useful in handling cases where spammers will make one connection and then send a large amount of messages with that connection.
SSL - Check this box to enable autodiscover to use SSL. Note: Autodiscover generally requires the use of SSL.
Allow relay for authenticated users - Select this checkbox to enable the "Allow Relay" setting from above when users are required to use SMTP Authentication for sending messages.
Outbound IPv4 - The IPv4 address used to connect to external SMTP servers when a message is sent by the domain. If multiple IPv4 IPs are on the server, they will be listed in the dropdown.
Outbound IPv6 - The IPv6 address used to connect to external SMTP servers when a message is sent by the domain. If multiple IPv6 IPs are on the server, they will be listed in the dropdown.
Enable Primary IP on failure - Select this checkbox to have SmarterMail automatically fall back to the primary IP when a failure has occurred. SmarterMail will only attempt to connect once if this option is enabled.
Command Timeout - If the server receives a command that sends large amounts of data but the data stops coming in for this number of seconds, the command will be aborted. By default, the command times out after 60 seconds.
Enable DNS Caching - Select this checkbox to cache the results of DNS calls in SmarterMail. This can help speed up delivery of messages.
Append authenticated as header for outgoing messages - Checking this box means that outgoing messages will have a new line item in the message header called "x-smartermail-authenticatedas" that demonstrates that the message sender was verified using SMTP authentication. This header can then be used by anti-spam services for validation.
Enable Remote Bounces - Select this checkbox to enable bounce messages from all senders. When unchecked, bounce messages are restricted to only internal senders. Note: This setting is enabled by default.
Web Chat URL Listeners - The URLs that XMPP services should listen to in order to ensure live chat connections are made. Examples include "http://+:80/http-bind/" or "https://+:443/http-bind"
Autodiscover Host - The URL of the mail server (e.g., mail.domain.com) to be returned by an auto discover query when Exchange ActiveSync is enabled.


Hello everyone!!! Can it be November 1st already?! Can you guys believe that it is the beginning of the amazing and crazy month that is Nanowrimo? (Eeeek!) How are you all feeling? I am a mixed bag of emotions- excited to start a novel that's been in the back of my mind all October, and … Continue reading NaNo Day 1 // My Nanowrimo WIP!


text:
Benjamin Insfran (Porto Murtinho, 1972) é um voleibolista brasileiro praticante da modalidade de vôlei de praia que conquistou a medalha de bronze na edição do Campeonato Mundial de Vôlei de Praia de 2003 no Brasil, e finalizou no Circuito Mundial de 2003 na segunda posição.Também disputou a edição dos Jogos Olímpicos de Verão de 2004 na Grécia.

Carreira

A trajetória de Benjamin como desportista iniciou quando atuava no voleibol de quadra (indoor),  a após sofrer sucessivas lesões decidiu migrar para o vôlei de praia no ano de 1996.Em 2002 foi vice-campeão do Circuito Mundial de Vôlei de Praia.

Atuando com seu parceiro Márcio Araújo disputou a edição do Campeonato Mundial de Vôlei de Praia de 2003, realizado no Rio de Janeiro, ocasião que conquistaram a medalha de bronze, ao final da temporada do Circuito Mundial de Võlei de Praia deste ano finalizaram com vice-campeonato.

E com Márcio disputou a edição dos Jogos Olímpicos de Verão de 2004, sediado na cidade de Atenas, e foram eliminados nas oitavas de final pela dupla de irmãos suícos Martin Laciga e Paul Laciga.

Foi premiado como atleta revelação do Circuito Brasileiro de Vôlei de Praia do ano de 1999, época que terminou na quarta posição do circuito brasileiro, conquistou  o título do Circuito Banco do Brasil em 2000 e  também no mesmo obteve os vice-campeonatos nos anos de 2002 e 2003. E ser eleito o melhor jogador do Brasil em 2000 e 2002, ano que também foi o melhor ataque e o melhor bloqueio e bronze na edição do ano de 2005.

Títulos e resultados

 Circuito Brasileiro de Voleibol de Praia Open:2000
 Circuito Brasileiro de Voleibol de Praia Open:2003
 Circuito Brasileiro de Voleibol de Praia Open:2002
 Circuito Brasileiro de Voleibol de Praia Open:2005
 Circuito Brasileiro de Voleibol de Praia Open:1999

Premiações individuais

MVP do Circuito Brasileiro de Vôlei de Praia Open de 2002
Melhor Bloqueio do Circuito Brasileiro de Vôlei de Praia Open de 2002
Melhor Ataque do Circuito Brasileiro de Vôlei de Praia Open de 2002
MVP do Circuito Brasileiro de Vôlei de Praia Open de 2000
Revelação do Circuito Brasileiro de Vôlei de Praia Open de 1999

Ligações externas

Jogadores de voleibol de praia do Brasil
Voleibolistas de praia nos Jogos Olímpicos de Verão de 2004


text:
Home Australia VictoriaLake Goldsmith
Lake Goldsmith (Vic)
Family Counts by Total weekly income
There are no families in the suburb of Lake Goldsmith (Vic) that have a negative income. (ABS, Census 2016)
There are no families in the suburb of Lake Goldsmith (Vic) that have no income. (ABS, Census 2016)
There are no families in the suburb of Lake Goldsmith (Vic) that have an income of between $1-$149 per week ($1-$7,799 per year). (ABS, Census 2016)
There are no families in the suburb of Lake Goldsmith (Vic) that have an income of between $150-$299 per week ($7,800-$15,599 per year). (ABS, Census 2016)
There are no families in the suburb of Lake Goldsmith (Vic) that have an income of between $300-$399 per week ($15,600-$20,799 per year). (ABS, Census 2016)
There are no families in the suburb of Lake Goldsmith (Vic) that have an income of between $1,000-$1,249 per week ($52,000-$64,999 per year). (ABS, Census 2016)
There are no families in the suburb of Lake Goldsmith (Vic) that have an income of between $1,750-$1,999 per week ($91,000-$103,999 per year). (ABS, Census 2016)
There are no families in the suburb of Lake Goldsmith (Vic) that have an income of between $2,000-$2,499 per week ($104,000-$129,999 per year). (ABS, Census 2016)
There are no families in the suburb of Lake Goldsmith (Vic) that have an income of between $8,000 or more per week ($416,000 or more per year). (ABS, Census 2016)
Values less than 4 may have been modified to preserve confidentiality (ABS).
Related Tables
Population by Sex by Occupation
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Skylar Plux Adventure On Clover Island Review Marrying Old With New
Skylar & Plux: Adventure on Clover Island Review - Marrying Old with New
By: Matthew Arrojas
We are currently in the midst of a 3D platformer revival, and Skylar & Plux: Adventure on Clover Island is the latest game to throw its hat into the ring. Developed by Right Nice Games, Skylar & Plux manages to capture much of what made 3D platformers so popular during the PS1/N64 era while trimming some of the fat that current players no longer find appealing. Skylar & Plux's linear platforming is a breath of fresh air. So fresh, in fact, that my biggest complaint with the game is that it isn't longer. It took me just over three hours to beat the game, while I gladly would have played for double or triple that amount of time.
"It's not about the size, but how you use it." -A wise, old man, probably
While the game's length may have been my number one problem with the game, it certainly wasn't my only one. Coming in at a close second was the game's story. Basically, all you need to know is that Skylar and Plux need to find three relic-like items before some bad guy gets them. Each item is in a different part of the map, and that's where the gameplay fits in. Unfortunately, all the game's jokes fall flat, the characters are completely two-dimensional, and there's barely any story to dive into. It seems that the game was written with children in mind, and while this isn't a bad thing in it of itself, I still wish that there was something for gamers over the age of 12 to grab onto when it comes to the story.
When it comes to graphics, Skylar & Plux is certainly a pretty looking game, although frame-rate drops occasionally hamper the experience.
Story elements aside, Skylar & Plux is a game accessible to gamers of all ages. It's clear that the game takes elements from a wide range of classic 3D platformers like Ratchet and Clank and Spyro. Better yet, Skylar & Plux takes only the good parts of those classic games and doesn't bring along some of the mechanics and features that have been phased out over the past couple generations.
For example, Skylar & Plux realizes that in a linear platformer, it's best not to include endless collectibles that are required to advance the story. If you so choose, you can free some of the captive natives of Clover Island, and you are rewarded with extra health for doing this. There are also hundreds of crystals scattered around the map, but these are used mostly for healing yourself and rescuing the captives. Of course, they're also addicting to collect, much like the bolts in Ratchet and Clank. While a lack of collectibles may be a detriment to more open 3D platformers, it works perfectly in Skylar & Plux and helps make the game even more accessible than it already is. Unfortunately, this also means that Skylar & Plux has very little replay value. After I beat the game, I simply didn't care about going back to free the captives that I missed. This lack of replay value is especially disappointing considering the game's length.
As for the platforming itself, Skylar & Plux feels tight and fair. I rarely ever found myself frustrated with the way the game controlled, and perhaps more importantly, the game's camera never felt like a nuisance. There are very few things in this world worse than a bad camera in a platformer, but Skylar & Plux thankfully doesn't have this problem. It also helps that the levels themselves are designed with platforming in mind first and foremost.
This might actually be Sony's upcoming Spider-man game. Probably not, but maybe...
However, this isn't to say that platforming is the only thing you'll be doing in Skylar & Plux, nor is it the only thing to do that's worthwhile. There's also a healthy dose of puzzles injected into the game. These are basic and relatively easy, but still well made nonetheless. The best way I can describe it is if you can imagine a pretty simple dungeon from The Legend of Zelda: Ocarina of Time. Sure, the dungeon is easy, but that doesn't mean it's not fun to work through or that you don't still get a sense of satisfaction from completing it. All in all, the puzzles help break up the gameplay a bit and add variety to the game so that it's not 100% just fighting a few different enemy types (the game definitely could have used more variety in this department) and doing some light platforming.
It also helps that throughout the game, a few gadgets are introduced. Well, only three to be exact, but they set up a few interesting puzzle scenarios. For example, there's a gadget that can reverse time in a certain area, restoring ruins to their original state and allowing you to reach new areas in that level. Again, it's all pretty easy, but enjoyably novel in its own way.
[embed]https://www.youtube.com/watch?v=QgzyIKa42CM[/embed]
Like I said in the beginning, it's hard not to feel incredibly disappointed by how short Skylar & Plux is. If you purchase games based on hours of gameplay per dollar spent, then it may seem as though Skylar & Plux is a waste of time and money. However, there are so many enjoyable aspects of the game that it's hard for me not to recommend it to anybody in search of a 3D platformer. Skylar & Plux lays some solid groundwork for a sequel that I hope will succeed in the few areas where this game failed.
TechRaptor was given Skylar & Plux: Adventure on Clover Island for the purposes of review. It was reviewed on the PlayStation 4 and is also available on Xbox One and PC via Steam.
Fans of the 3D platforming genre should definitely pick up Skylar & Plux: Adventure on Clover Island. Heck, even gamers who aren't obsessed with the genre should give it a shot. Skylar & Plux is accessible to a whole range of gamers, and while the game's biggest shortcoming is its length, there are still plenty of features that can make your playthrough worthwhile.
Tight Platforming
Good Level Design
Fun Yet Simple Puzzles
Controls Well
Far Too Short
Story Aimed At Kids
Matthew Arrojas
Just because I write about video games doesn't mean I'm very good at them. Unless it's Smash Bros. I'll wreck you in Smash Bros. I am also currently obsessed with Overwatch, so I'll wreck you in that too with Mercy.


text:
Q: Meteor call beforeSend, save request before sending on server i am doing a few HTTP requests on my meteor / nodejs server.
try {
      const result = HTTP.get(endpoint, {
        'headers': ...
        'timeout': 5000,
      });
      return { data: result.data };
    } catch (error) {
        handleError(error);
    }

i want to store / save my request before sending.
I use the server to send my HTTP requests. AFAIU the beforeSend is only when sending the requests from the client.
Any ideas how i can save my request before executing or can i use the beforeSend also on meteors server side?
Thx.

redpajama_set_name: RedPajamaStackExchange


This vote was a procedural vote to kill an amendment offered by Senator Lee that would have defunded implementation of a Department of Housing and Urban Development rule that basically federalizes zoning laws and encourages the forced economic diversification of neighborhoods. Rhetorically speaking this rule is a war on the suburbs as it uses the power of federal government to centrally plan out neighborhoods. The rule is a massive power grab by progressive bureaucrats to allow them to conduct large-scale social experiments with real neighborhoods by forcing the collection of data that will be used to evaluate whether communities meet Washington guidelines and quotas on race, economic, and other factors. The result will undermine local representation and push localities into more regional government structures that ultimately answer to Washington D.C. The vote to kill the amendment was agreed to on May 19, 2016 in a roll call vote of 60-37.


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Paroligembia ethiopica is een insectensoort uit de familie Teratembiidae, die tot de orde webspinners (Embioptera) behoort.

Paroligembia ethiopica is voor het eerst wetenschappelijk beschreven door Ross in 2006.

Webspinners


Most professionals have had bosses or managers they do not like. Perhaps these supervisors are too demanding, grouchy, negative, or downright mean. Or they may be too soft and timid, failing to offer opportunities for growth or to help further their team members' careers.
So now you are a manager — what kind of supervisor are you? Do you offer serious, constructive criticism? Are you authoritative to the point of being annoying and feared by your workers? Or are you so worried you will alienate your staff that you are too easy-going, acting like a buddy instead of a boss?
That sounds logical, but here is the problem: Many managers fall into their supervisory roles without any training. Few receive guidance on how to lead and encourage, and the reality is that transitioning into a managerial role takes thought, study, and practice. Too often, new managers struggle with the balance between demanding high performance while still being liked and respected by their staff.
As a result, unseasoned managers make mistakes. They pretend to motivate their employees but silently fear that if the project flops, or the client walks, they as the supervisor may be in trouble, Gupta said. Some managers wrongly believe that being tough means being unreasonable. They may regularly correct employees who make blunders, being critical versus constructive.
The bottom line, said Karin Tenelius, founder and CEO of Tuff Leadership Training in Stockholm, is that many of today's supervisors — even young ones — still mirror the parent-child leadership model that has existed for decades. "Management hasn't evolved or developed much from those historic times, and that's why managers are stuck in a paradigm," she noted.
Tenelius and Gupta offered the following advice on how managers can set rigorous expectations and demand high performance without alienating employees.
Do not settle. First and foremost, maintain high performance expectations, with the notion that you will not only be helping your company, but yourself and your staff as well. A manager who "raises the bar" will not only motivate employees, but continually push them to stretch their limits past their comfort zones, Gupta said.
Create an environment of safety and trust. Don't be the boss your employees dread to visit. Instead, give them an open door they can walk through without fear of retribution. "Tell them, 'I will never violate your trust or confidence,'" Gupta said. Good managers care about people, are interested in what they have to say, and possess excellent listening skills, Tenelius added.
Know your staff. Walk in your staff's shoes and understand their skillsets, strengths, and weaknesses. Know what is holding them back, and what motivates or intimidates them, Gupta said. Sit down with your employees and explain what you expect of them. Ask yourself often how you have helped them improve and contributed to their professional growth. "We work harder for those who are more flexible and understanding," added Gupta.
Be precise with praise. When complimenting an employee, be specific — otherwise praise has little meaning. "If you say, 'Good job', that's what I call fairly useless praise," Gupta said. Instead, pay tribute to your employee for completing a specific project or report, meeting a deadline, or helping to land a new client. Let the person know exactly what they did to deserve your approval.
Give employees authority. If your staff is dissatisfied with the work schedule, for example, allow them to create one that is more effectual without hurting the company, Tenelius said. If employees believe meetings are boring, give them some autonomy to try to improve the format. "Let them impact the structures," she added.
Ask for input from your team in meetings. Start gatherings by asking employees about the most pressing issues to be discussed. "That way things will get done or move forward faster than if you try to drive your team," Tenelius said.
— Cheryl Meyer is a freelance writer based in the US. To comment on this article or to suggest an idea for another article, contact Drew Adamek, an FM magazine senior editor, at Andrew.Adamek@aicpa-cima.com.


Today, the Department of Health Secretary Bruce D. Greenstein announced the members of the BAYOU HEALTH Quality Committee.
BAYOU HEALTH is the transformation of the State's Medicaid program in which two-thirds of recipients will have their care coordinated through networks administered by five private Health Plans. LDH chose to form the Quality Committee to provide oversight and monitoring of the program. Under the rules and contracts that govern BAYOU HEALTH, there are extensive requirements regarding health outcomes, quality measures and consumer engagement.
Health Plans are required to participate on the Quality Committee and will be measured on 37 clinical quality measures. The Health Plans face potential financial sanctions from the State if they do not meet minimum health quality improvement benchmarks for their members. LDH will publish regular reports on Health Plan quality and financial performance online.
"Our primary objective from day one in BAYOU HEALTH has been improving the health of Louisiana residents," Greenstein said. "This committee represents some of the sharpest medical minds in our State, and they will provide the oversight and expert guidance needed to raise the bar."
This 19-member committee includes health care quality experts, advocates, provider organizations and representatives of the the five BAYOU HEALTH Plans whose role is to advise LDH on best practices, provider relations, ongoing quality improvement measures and recommendations for changes to BAYOU HEALTH's structure as appropriate. The committee also includes representatives of both the Senate and House Health and Welfare committees.
The Committee Chairman is Medicaid Medical Director Dr. Rodney Wise. The Committee will meet at least quarterly, and more often as necessary. Meetings will be open to the public, with meeting dates and minutes published online at www.MakingMedicaidBetter.com.
Maitland Deland, M.D., Radiation Oncologist, President and CEO, Oncologics, Inc.
"BAYOU HEALTH will be fully launched across our state on June 1," said Chairman Dr. Rodney Wise. "As we move into the operational phase, this committee will be instrumental in providing real-time evaluation and oversight so we can ensure continuous improvement and better health for our enrollees."
The final phase of BAYOU HEALTH implementation includes the parishes in Southwest, Central and North Louisiana. Recipients in these areas will transition to BAYOU HEALTH on June 1, at which time the program will be fully implemented statewide. Medicaid recipients in the New Orleans and Northshore regions transitioned to BAYOU HEALTH on Feb. 1, and recipients in the Capital Area, Acadiana and South Central Louisiana transitioned on April 1.
For more information about BAYOU HEALTH, please visit www.makingmedicaidbetter.com.


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County Chairman Praises "Key Role" Of Supporters' Association
Worcestershire CCC chairman Fanos Hira has praised the "key role" played at Blackfinch New Road by the Worcestershire Supporters' Association in funding many key projects over many decades.
The Supporters' Association was formed in 1951 to boost the club's finances and provide better amenities for players and spectators and in 1976 purchased New Road for the County Cricket Club.
This year alone they have spent £92,400 on funding the new and upgraded Chestnut Marquee, a new Association Club Shop situated next to the Graeme Hick Pavilion and a tractor-roller for head groundsman Tim Packwood and his team.
Fanos Hira said: "The Supporters' Association have a key role to play in this club going forward. We as a club are very grateful for the tireless voluntary work.
"I was fortunate enough to be able to attend their last committee meeting and we went through in a lot of detail the projects they have been working on during the last year.
"It is really remarkable how much they contribute through their efforts and we as a club are hugely grateful to them for that.
"Their assistance really adds up. It is staggering. For 2018 alone, they have contributed £92,400. That's £92,400 that either had to be spent or found by the club – or perhaps not because it wasn't able to do so at the time.
"It is an enormous contribution to the club and it's great and they've been doing the same sort of thing for many, many years.
"It is not just the financial contribution. It is the tireless efforts of Andrew Jenkins (chairman) and his team and we fully recognise that.
"Clearly they have made an enormous contribution and the Board, the Executive look forward to working really closely with the Supporters' Association.
"If we work closer, then everyone benefits because one of the things I mentioned when I spoke about finances at the last AGM is that this club isn't one that wants to puff its chest up and boast about making huge profits.
"On the contrary, all we want to do is be better at everything so we can invest more in cricket and make sure the facilities are better for members so they come back and spread the word about how great it is to be here."
Fanos added: "The club is also really grateful for the contribution the Association is going to make over the winter period.
"That involves concreting on the site of where the Club Shop is, and at the back of the D'Oliveira Stand with widening the road, plus assisting with finance for new netting systems for the players that the club is looking at and also a new hut for our stewards at the entrance to New Road.
"It is clearly improving the facilities and that's what we are all going to do. We are all going to work together to invest more in cricket and make the experience nicer and the Supporters' Association contribute hugely to that."


Sushi does come ito many guises and shapes (and colours).
Too many people think it is only all nigiri and rolls.
Any chef worthy of his/her name will prove you otherwise!
Alright, then. What do they have to offer?
Nigiri/握り literally means "grip/grasp/press" in Japanese.
The shari/シャリ is made by scooping the right amount of sushi rice in one hand (usually the left hand) and making a "ball" of it. Actually it is more oblong than round. Size varies with the chef and restaurant, but an experienced chef is capable to reproducing such a ball to the same exact amount of grains. They say it takes seven years to become a master at making shari!
The next step, but not always, is to smear a little wasabi on top of the rice ball and then top it with an ingredient of your choice. Finally the chef will press it around the top of the shari before depositing it on a plate (or on a bamboo leaf) or on small wooden plate in front of the customer.
In some cases the wasabi will be placed in the from of a small ball on top of the neta/ネタ (topping) as on anago/アナゴ (conger eel).
All kinds of neta/toppings can be wrapped around the top.
A strip of dried seaweed/nori/海苔 can be used to secure the neta as with tamagoyaki/卵焼き above.
When a wider strip of nori is wrapped around a shari to prevent the topping to fall over, it is called a gunkan/軍艦/mothership.
or it can be designed as purposefully overflowing as above (ikura/salmon roe gunkan)!
What about this tiny St-Valentine Gunkan?
For more gunkan fun go HERE!
It is very popular in homes where large quantities can prepared for the family and still designed as to please the eye.
Bread + Butter, Zoy Zhang, Hungry Neko, Think Twice, Frank Fariello, Mangantayon, Hapabento, Elinluv Tidbit Corner, Tokyo Terrace, Maison de Christina, Chrys Niles,Lexi, Culinary Musings, Wheeling Gourmet, Comestiblog, Chronicles Of A Curious Cook, Tokyo Through The Drinking Glass, Tokyo Foodcast, Palate To Pen, Yellin Yakimono Gallery, Tokyo Terrace, Hilah Cooking, More than a Mount Full, Arkonite Bento, Happy Little Bento; 5 Star Foodie; Jefferson's Table; Oyster Culture; Gourmet Fury; Island Vittles; Good Beer & Country Boys; Rubber Slippers In Italy; Color Food daidokoro/Osaka;/a; The Witchy Kitchen; Citron Et Vanille, Lunsj Med Buffet/Estonian Gastronomy (English), Cook, Eat, Play, Repeat, Chrisoscope, Agrigraph, The Agriculture Portal to shizuoka!


Recapping isn't just for soda bottles too big to finish. It's also what we do here every week, as we share a look inside Kickstarter HQ. Enjoy!
Fire up the grill and dust off the lawn darts, because—here in the States, at least—it's Memorial Day weekend. That means three days of sun, fun, and this track playing on loop in the background. Some folks will even break out the flip flops, but we hope they're careful.
Meanwhile, the most essential summer project ever, Coolest Cooler, just announced they'll begin shipping this July. We're stoked! That's a pretty incredible turnaround on one of the biggest projects of all time. They also shared this glimpse at their engineering pilot build—a complete, assembled, functional Coolest!
What color did you order? We chose Margarita. Having this thing poolside is going to be so delightful.
On the topic of shipping, we just made Kickstarter available to creators in Spain! They can start building their projects immediately. Some folks on our team are actually heading across the pond to make an appearance at Sónar+D in June. They'll be leading workshops and preparing our international neighbors for success. Meanwhile, creators in Spain will be able to launch their projects starting June 2.
Mail Call! The best part of working at Kickstarter is the weird and unexpected stuff that arrives the mail. This week we received our Otto. Remember that? It's a raspberry pi-powered GIF camera! It's still charging, but maybe we'll share some stuff we made next week.
We also got this wickedly cool piece of original art, from the Paintings for Strangers project. Now we just need a stranger to give it to.
Oh! Have you heard of the Verrado Electric Drift Trike? We got one for the office last year, but after weeks of sick tricks and indoor drifting (NOT RECOMMENDED), we broke it. This week we finally got around to repairing the bike, so our office manager, Charlie, took to the streets to show us how it's done.
Glad that there are some projects that can be called a success. Unfortunately, there have been more projects that are deemed scams - not failures, but scams. And a lot of backers are left licking their wounds and empty wallets.
Kickstarter needs a better way to filter out frauds and post metrics on successes, failures, and scams (no actual project, fraudulent claims, and fly by night operations). If not, backers should be hesitant and stop contributing. If you have already been burned, file your complaint with the FTC.


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That bite in the air and you're searching for that stylish, extra layer to wrap around you. There's nothing wrong with wanting to go Over the Top for fall!
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CANADA/US 0 2 4 6 8 10 12 14 16
GERMANY 30 32 34 36 38 40 42 44 46
ITALY 36 38 40 42 44 46 48 50 52
FRANCE 32 34 36 38 40 42 44 46 48
MARC CAIN 1 2 3 4 5 6 7
MAJESTIC 1 2 3 4
Measurements (Inches)
BUST 31 32 33 34 1/2 35 1/2 37 38 1/2 40 41 1/2
WAIST 24 25 26 27 28 29-30 31 32-33 32-34
HIPS 34 1/2 35 1/2 36 1/2 37 1/2 38 1/2 40 41 1/2 43 44 1/2
Measurements provided are a general guide. Every body has its own unique proportions.
Email info@andrewsco.com if you'd like further guidance.


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Donald Trump Featured Geopolitics Law Enforcement/Crime Military/Defense Terrorism/National Security
Trump advised to nail and prosecute intelligence community leakers
May 31, 2017 May 31, 2017 NACOP Chiefs of Police - James Kouri 0 Comment British intelligence, British military and police, leaking classified information, Manchester bombing
To a number of law enforcement and intelligence veterans, the only positive thing one can say about Brennan is that he's loyal. Too bad he was loyal to the wrong Commander in Chief.
Britain has resumed sharing intelligence with the U.S., as police make progress in their search for bomber Salman Abedi's terror network. On Thursday morning, United Kingdom officials angrily stopped handing over information relating to the bombing of the Ariana Grande concert in Manchester following a series of alleged leaks to the American news media by suspected members of the American intelligence community.
But following President Donald Trump's reaction to the British complaint, Britain's most senior counter-terrorism officer said this evening that the matter has been resolved after "receiving fresh assurances."
"President Trump was visibly angry with this continuation of classified information being leaked by intelligence agency members designed to embarrass the administration. The Trump administration must track down these leakers and prosecute them to the fullest extent of the law," said former police captain Timothy Patrick. "The intelligence community appears to be out of control thanks to the politicizing of agencies — under the blabbermouths in the Obama White House — handling highly classified material," added Patrick.
In a statement, National Police Chiefs Council Assistant Commissioner Mark Rowley said: "While we do not usually comment on information sharing arrangements with international law enforcement organizations we want to emphasize that, having received fresh assurances, we are now working closely with our key partners around the world."
Commander Jane Connors, who is leading the London policing operation, said: "We will do all we can to protect the Capital that we serve at this unsettling time. All our work is designed to make our city as hostile an environment as possible for terrorists to plan and operate.
"The reality is that we must be prepared to be able to respond to and deal with armed and deadly attackers, so we must be in a position to respond with firearms officers who will use force to stop those attackers in their aim. That is why is we have increased the number of firearms who are on duty, both out walking and in roaming patrols, at fixed points and carrying out a range of operations.
"We are using every tactical option – not just through the use of armed officers but ongoing work by the Counter Terrorism Command; working with partner agencies and gathering community intelligence.
"Whilst some of what we are doing will be obvious to the public there is a huge amount of work happening day and night that the public will never know about."
Commander Connors added: "At this time we need the people of London to remain calm but alert. If you see anything that causes you concern then let us know immediately, if you have suspicions about someone's behaviour call us. We need your help to help us protect the capital and thwart the terrorists who seek to divide us and undermine our way of living."
In a separate statement from Britain's National Police Chiefs Council on Thursday, they stated:
"We greatly value the important relationships we have with our trusted intelligence, law enforcement and security partners around the world. These relationships enable us to collaborate and share privileged and sensitive information that allows us to defeat terrorism and protect the public at home and abroad.
"When that trust is breached it undermines these relationships, and undermines our investigations and the confidence of victims, witnesses and their families. This damage is even greater when it involves unauthorized disclosure of potential evidence in the middle of a major counter terrorism investigation."
← National news outlets suffering backlash over cover up of DNC's Seth Rich murder case
Actor and Writer Michael Moriarty: The New World Order Empire →
NACOP Chiefs of Police - James Kouri
Jim Kouri is a member of the Board of Advisors and a former vice president of the National Association of Chiefs of Police, Inc. a 501 (c) (3) not-for-profit organization incorporated in Florida in May 1967. The Association was organized for educational and charitable activities for law enforcement officers in command ranks and supervisory agents of state & federal law enforcement agencies as well as leaders in the private security sector. NACOP also provides funding to small departments, officers and the families of those officers paralyzed and disabled in the line of duty.


I did the drawing for a new Rose painting.
It is a Pink Rose with a lot of leaves and three buds and a tiny mini bud. So I think this rose is perfect for you to learn how to paint a rose.
I will paint this Rose on 140 Lb hotpressed Watercolor Paper. Usually I always stretch my paper, but I want to try new things. So this time I will paint directly on the blog without stretching and see how it works. Will it make a difference when the paper is untouched and was not yet in water? Hmmm … I am really curious.
I will do this Rose demonstration painting with a white background. I have done a photo of the drawing, so it will give a good suggestion how it looks. But it also can be that I will change some of the leaves during the paint process, add some more, change the angle, form and so on.
For my pinks I will use Transparent Rose from W&N, Alizarin Crimson from Schmincke, some Indian Yellow and Phthalo Blue (both are also from Schmincke). Of course I will not forget to add some green of the leaves on the flowerpetals, to get colourharmony. As you know each subject is reflected by things arround it, so I will also add some pinks on the leaves later.
I will make some photos of the painting process. I am sorry when the photo of the drawing is not better, I just made light pencilstrokes, which I also will erase before adding the colours. I do not like to see later the pencildrawing.
I will start at first on the big mainflower and then I also will start with working on the leaves.
I have started with painting the rose.
In the first photo you can see that I have already some yellow underwashes.
I used Indian Yellow on the Rose – where I think where the warm areas are.
I then used also Indian Yellow on some of the leaves, but I also used Aureolin (a cool yellow) on other leaves.
In my previous post I made a mistake. I do not use Transparent Rose, the right name of the colour from Winsor and Newton is Permanent Rose. I am sorry for this mistake.
Did I already tell you that this rose composition is done from several photos which I did about this Pink Rose? Although I worked a bit on photoshop for the composition, the rest was created when I did the drawing. So I really have no real idea how this painting will look like when it is finished.
This is always an interesting part to see how the painting will develops.
So while painting I think it will help when I add more and more colours on different parts and not only concentrate on maybe the rose.
In the second photo you will see that I have add some colours. For the warm areas on the Rose (where also the yellow underwash is) I added a mix of Alizarin Crimson and Permanent Rose. For the neutral tones I used only the Permanent Rose and for the very cool areas I use the Permanent Rose mixed with Phthalo Blue.
On the leaves I am using yellow as mentioned above and also Sap Green (from Daniel Smith). I also added Alizarin Crimson there and of course Phthalo Blue is also used. I have a wonderful Turqoise Colour in my box (Helio turquoise from Schmincke), which is a beautiful colour, so maybe I will work with this colour too on cooler areas. I love Turquoise colours.
Also it is great to drop in the colours instead of doing brushworks. I mean wet the area and then drop the colour in and it will flow naturally.
I will go on and adding more colours now.
I have worked further on this Pink Rose Watercolor painting. More leaves are painted and the main rose is also finished. I really love what I have done yet and I am very pleased about this Watercolor painting.
It also makes a lot of fun to paint on the unstretched paper in the blog. I never have done this with hotpressed paper before and a fellow artist told me that she always did this and never got any buckles, so I needed to make things easier for me, instead of wasting my time with wetting, stretching, dryingtime etc.
I painted with the colours, which I mentioned before on the leaves as on the Rose.
Since this painting will have a white background, then it will be a botanical Rose painting.
The Rose Painting is finished.
It is only painted with transparent watercolors and I used all the colours which I mentioned before.
At first I was worried a bit about the composition and I had to cut some of the white area on the right side, it did not look good. But now as it is I really love it to have this painting in this way.
It worked also absolutely great on the unstretched hotpressed paper – it did not buckle in any way.
I am always looking for more information. How do other artists do. Your explanation has helped me to understand how to get the glow in my flowers. Wish you much painting excitement. What a wonderful passion we have.