text:
package org.apache.camel.component.ignite.messaging;

import java.util.UUID;

import org.apache.camel.Exchange;
import org.apache.camel.ExchangePattern;
import org.apache.camel.Message;
import org.apache.camel.Processor;
import org.apache.camel.component.ignite.IgniteConstants;
import org.apache.camel.support.DefaultConsumer;
import org.apache.ignite.IgniteMessaging;
import org.apache.ignite.lang.IgniteBiPredicate;
import org.slf4j.Logger;
import org.slf4j.LoggerFactory;

/**
 * Ignite Messaging consumer.
 */
public class IgniteMessagingConsumer extends DefaultConsumer {

    private static final Logger LOG = LoggerFactory.getLogger(IgniteMessagingConsumer.class);

    private IgniteMessagingEndpoint endpoint;
    private IgniteMessaging messaging;

    private IgniteBiPredicate<UUID, Object> predicate = new IgniteBiPredicate<UUID, Object>() {
        private static final long serialVersionUID = -971933058406324501L;

        @Override
        public boolean apply(UUID uuid, Object payload) {
            Exchange exchange = endpoint.createExchange(ExchangePattern.InOnly);
            Message in = exchange.getIn();
            in.setBody(payload);
            in.setHeader(IgniteConstants.IGNITE_MESSAGING_TOPIC, endpoint.getTopic());
            in.setHeader(IgniteConstants.IGNITE_MESSAGING_UUID, uuid);
            try {
                if (LOG.isTraceEnabled()) {
                    LOG.trace("Processing Ignite message for subscription {} with payload {}.", uuid, payload);
                }
                getProcessor().process(exchange);
            } catch (Exception e) {
                LOG.error(String.format("Exception while processing Ignite Message from topic %s", endpoint.getTopic()), e);
            }
            return true;
        }
    };

    public IgniteMessagingConsumer(IgniteMessagingEndpoint endpoint, Processor processor, IgniteMessaging messaging) {
        super(endpoint, processor);
        this.endpoint = endpoint;
        this.messaging = messaging;
    }

    @Override
    protected void doStart() throws Exception {
        super.doStart();

        messaging.localListen(endpoint.getTopic(), predicate);

        LOG.info("Started Ignite Messaging consumer for topic {}.", endpoint.getTopic());
    }

    @Override
    protected void doStop() throws Exception {
        super.doStop();

        messaging.stopLocalListen(endpoint.getTopic(), predicate);

        LOG.info("Stopped Ignite Messaging consumer for topic {}.", endpoint.getTopic());
    }

}


Spencer Parker - Change Yo Beat Spencer Parker's productions have always veered off the house and techno straight and narrow, but "Change Yo Beat" sounds like the kind of stock record the Brit DJ would work into the middle of his set. It's gritty, unfussy house. A vocal loop appears a minute or so in and sticks there, but the track's primary tools are punchy, breathless kick drums and rattling two-note stabs. It's unpretentious and confident dance floor fare.
Ryan Elliott's remix has a similar aesthetic, but he comes at it from a different angle, twisting the track into a pitched-up, high-stepping techno roller. Its helicoptering beats, metallic clanks and an oppressive Twilight Zone hum are tailor-made for the darkest corners of both mind and club.


text:
Q: Automatic backup and restore of Aerospike namespaces I have a namespace 'test' in Aerospike. I can easily creates it backup and restore it using the following commands:
Backup:
asbackup -h localhost -n test  -d /home/asif/aerobckups -r

Restore:
asrestore -d /home/asif/aerobckups

But I need to explicitly run these commands. I want to do this operation in a way like: I have set TTL 30d in namespace. As TTL reaches so on 30th day it automatically creates backup and restore namespace (I will make backup and restore on different server). Is there any way to do it? if it is available as a property in namespace then it will be very nice but suggestions related to init.d are also welcomed.

A: You can try writing a bash script with the backup and restore commands in it. Set the script to automatically run after every 30 days.
#!/bin/bash
#Backup:
asbackup -h localhost -n test  -d /home/asif/aerobckups -r

#Restore:
asrestore -d /home/asif/aerobckups

Run it using:It will run every 4th week
0 0 * * 4 /home/ramesh/backup.sh

redpajama_set_name: RedPajamaStackExchange


text:
import { bind } from '@ember/runloop';
import { defer, resolve } from 'rsvp';
import { assign } from '@ember/polyfills';
import Service from '@ember/service';
import { set, get } from '@ember/object';
import { task } from 'ember-concurrency';

/**
  Example:

  ```js
  export default Ember.Route.extend({
    flash: method(),

    deleteItem: task(function * (item) {
      try {
        item.deleteRecord();
        yield this.flash('Deleting Item', {
          timeout: 5000
        });
      } catch {
        item.rollback();
      } finally {
        item.save();
      }
    })
  });
  ```
*/
export default Service.extend({
  message: null,

  _notify: task(function * (text, options) {
    let message = assign({
      text,
    }, options, defer());

    try {
      set(this, 'message', message);

      if (options.timeout) {
        // Race promises; this uses setTimeout instead
        // of Ember.run.later so we can test undo / dismiss.
        // If we didn't do this, tests would pause until
        // the action completed on its own
        this._timer = setTimeout(
          bind(null, message.resolve),
          options.timeout
        );
      }

      yield message.promise;
    } finally {
      set(this, 'message', null);
      clearTimeout(this._timer);
      this._timer = null;
    }
  }),

  execute(text, options={}) {
    // Resolve any messages being shown
    if (get(this, 'message')) {
      get(this, 'message.resolve')();
    }

    return resolve().then(() => {
      return get(this, '_notify').perform(text, options);
    });
  }
});

redpajama_set_name: RedPajamaGithub


Cell C data packages are probably among the most competitive offers in the South African internet data market. South African's spend a considerable amount of time online. As such, there will always be demand for internet bundles which creates a lot of competition. Users, on the other hand, want something reliable to enable them access fast and stable internet without being overpriced. Affordability may be relative, but it is a key component for users looking to find great offers.
The company is organized in such a way that it has numerous data packages. This helps to accommodate all customers ranging from those requiring small amounts to real guzzlers. Knowing what is available on offer is the first step to choosing the perfect package.
Before we get into the pricing and package figures, we may want to start with the basic questions. How do you buy C cell data bundles? This may seem like an obvious question, but it is equally important. Once you understand the packages that are available, you need to know how to access them in the first place. Here is how you go about the purchase. The prices may vary, but the method of buying is the same.
To enjoy more of Cell C internet services, you will have to choose between their contracts or top up plans.
Media play data which delivers necessary connections to your home and offices at a fast 4G network. It comes with a free black and exclusive to watch plan, all on one bill.
Smart data. So what is mart data internet? This is an extensive package with several smart plans.
LTE A package offers you around 5 plans to choose from. All of them deliver fast internet speeds for your needs.
Whatsapp bundle. This package allows you to have 30-day access to Whatsapp at only R17.
Always On bundle allows you to browse whenever you want because you have access to constant hotspot all over the country.
These are priced according to the amount of data and type of data usage. The following breakdown will be helpful. Dail *109# to purchase.
The advantage of Cell C data bundles is that they do not expire. What you have to do is to ensure that you buy another data package within that period and they will be carried over.
This is a fast method of accessing internet on Cell C network as long as you are connected to the router. You can connect over 32 WiFi-enabled devices conveniently. The LTE packages can either be fixed or ISP enabled. The following is a breakdown of the 2 categories.
These are the monthly prices for offers on anytime packages. These are offered on a contract basis where customers must sign for up to 24 months subscription.
These are also available on an anytime basis and are priced per month.
It is important to note that apart from the monthly and 24-month contract basis difference, the LTE offers vary in other ways. For instance, ISP packages have a Huawei B315 router that is provided by default. In case you want an upgrade to Huawei B618 you will have to pay a one-off charge of R999. It comes with a data top-up option that costs R12.50 for each GB. Cell C deals come with a Cell C RTL31VW LTE-A router and have no data top-up options.
The above Cell C data packages are among those that you can consider when looking for the best data deals for yourself. Whether you need internet for home usage, the office or even for your mobile on the go, check out what Cell C has to offer for some of the best deals ever. You may find the need for a Cell C upgrade.


text:
Search in titles only Search in Psychedelics only
Lifestyle & Hobbies
Psilocybin research
Audiogen requested some of the research happening with psilocybin, so I figured I'd post it here for everyone to take a look at.
There are too many restrictions on the forum re: file size and number of attachments, so I've put a bunch of articles in a google drive folder:
https://drive.google.com/drive/folde...t4?usp=sharing
I'll post the abstracts of the studies below, as I can't post that much in a single post apparently. I copied and pasted from PDFs, so the formatting might be a bit off, but I've mostly cleaned it up.
Last edited by eggsprog; 08-09-2020, 09:03 PM.
Brain scans of subjects dosed with psilocybin, according to research published Saturday in the journal Neuropsychopharmacology, reveal that the effect is related to a neurotransmitter called glutamate. In the brain, glutamate acts as a sort of "on switch" in that it helps propagate neural signals traveling across brain cells — and altering how much reaches different areas of the brain, the findings suggest, appear to trigger profound changes in perception.
Put plainly, the study reveals a bizarre fact about our consciousness: altering one biomolecule in our brains can profoundly alter our subjective ability to perceive ourselves and how we experience the world.
Even more provocatively, the study found that the activity levels of glutamate in various brain regions are directly linked to a person's experience on psilocybin — higher glutamate levels in the medial prefrontal cortex were linked to a negative experience of ego dissolution, while lower levels in the hippocampus were linked to a positive one. And it turns out that psilocybin causes both impacts.
https://futurism.com/neoscope/neuros...reak-down-self
oh, that's interesting. can you control/find out your levels of glutamate?
Originally posted by J Ruth
oh, that's interesting. can you control/find out your levels of glutamate
I am not aware of any supplements like 5-htp for serotonin that supposedly alters levels of glutamate. I would not be surprised if they exist but the fact that it causes different responses in different brain regions seems like it would be very difficult to control by a supplement..
Originally posted by Audiogen
Ah, so you might not be able to make it more likely to have a good trip, but it should be able to help predict likelihood of a bad one?
I'm not sure it all seems like very new research, I just got the impression that observations were made.
But another reason why this is fascinating is since you and I have been taking psychedelics, Serotonin and respective receptor subtypes have been essentially touted as providing the full breadth of the psychedelic experience and I've been skeptical of that claim for at least the past decade.
Last edited by Audiogen; 08-11-2020, 03:15 AM.
Griffiths et al. (2006) - Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance
Rationale Although psilocybin has been used for centuries for religious purposes, little is known scientifically about its
acute and persisting effects.
Objectives This double-blind study evaluated the acute and longer-term psychological effects of a high dose of psilocybin
relative to a comparison compound administered under comfortable, supportive conditions.
Materials and methods The participants were hallucinogen naïve adults reporting regular participation in religious or spiritual activities. Two or three sessions were conducted at 2-month intervals. Thirty volunteers received orally administered psilocybin (30 mg/70 kg) and methylphenidate hydrochloride (40 mg/70 kg) in counterbalanced order. To obscure the study design, six additional volunteers received methylphenidate in the first two sessions and unblinded psilocybin in a third session. The 8-h sessions were conducted individually. Volunteers were encouraged to close their eyes and direct their attention inward. Study monitors rated volunteers' behavior during sessions. Volunteers completed questionnaires assessing drug effects and mystical experience immediately after and 2 months after sessions. Community observers rated changes in the volunteer's attitudes and behavior.
Results Psilocybin produced a range of acute perceptual changes, subjective experiences, and labile moods including anxiety. Psilocybin also increased measures of mystical experience. At 2 months, the volunteers rated the psilocybin experience as having substantial personal meaning and spiritual significance and attributed to the experience sustained positive changes in attitudes and behavior consistent with changes rated by community observers.
Conclusions When administered under supportive conditions, psilocybin occasioned experiences similar to spontaneously occurring mystical experiences. The ability to occasion such experiences prospectively will allow rigorous scientific investigations of their causes and consequences.
Griffiths et al. (2008) - Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later
Psilocybin has been used for centuries for religious purposes; however little is known scientifically about its long-term effects. We previously reported the effects of a double-blind study evaluating the psychological effects of a high psilocybin dose. This report presents the 14-month follow-up and examines the relationship of the follow-up results to data obtained at screening and on drug session days. Participants were 36 hallucinogen-naïve adults reporting regular participation in religious/spiritual activities. Oral psilocybin (30 mg/70kg) was administered on one of two or three sessions, with methylphenidate (40 mg/70kg) administered on the other session(s). During sessions, volunteers were encouraged to close their eyes and direct their attention inward. At the 14-month follow-up, 58% and 67%, respectively, of volunteers rated the psilocybin-occasioned experience as being among the five most personally meaningful and among the five most spiritually significant experiences of their lives; 64% indicated the experience increased well-being or life satisfaction; 58% met criteria for having had a "complete" mystical
experience. Correlation and regression analyses indicated a central role of the mystical experience assessed on the session day in the high ratings of personal meaning and spiritual significance at follow-up. Of the measures of personality, affect, quality of life, and spirituality assessed across the study, only a scale measuring mystical experience showed a difference from screening. When administered under supportive conditions, psilocybin occasioned experiences similar to spontaneously-occurring mystical experiences that, at 14-month follow-up, were considered by volunteers to be among the most personally meaningful and spiritually significant of their lives.
Maclean et al. (2011) - Mystical Experiences Occasioned by the Hallucinogen Psilocybin Lead to Increases in the Personality Domain of Openness
A large body of evidence, including longitudinal analyses of personality change, suggests that core personality traits are predominantly stable after age 30. To our knowledge, no study has demonstrated changes in personality in healthy adults after an experimentally manipulated discrete event. Intriguingly, double-blind controlled studies have shown that the classic hallucinogen psilocybin occasions personally and spiritually significant mystical experiences that predict longterm
changes in behaviors, attitudes and values. In the present report we assessed the effect of psilocybin on changes in the five broad domains of personality - euroticism, Extroversion,Openness, Agreeableness, and Conscientiousness. Consistent with participant claims of hallucinogen-occasioned increases in aesthetic appreciation, imagination, and creativity, we found significant increases in Openness following a high-dose psilocybin session. In participants who had mystical experiences during their psilocybin session, Openness remained significantly higher than baseline more than one year after the session. The findings suggest a specific role for psilocybin and mystical-type experiences in adult personality change.
Griffiths et al. (2011) - Psilocybin occasioned mystical-type experiences: Immediate and persisting dose-related effects
Rationale—This dose-effect study extends previous observations showing that psilocybin can
occasion mystical-type experiences having persisting positive effects on attitudes, mood, and
Objectives—This double-blind study evaluated psilocybin (0, 5, 10, 20, 30 mg/70 kg, p.o.) administered under supportive conditions.
Methods—Participants were 18 adults (17 hallucinogen-naïve). Five 8-hour sessions were conducted individually for each participant at 1-month intervals. Participants were randomized to receive the four active doses in either ascending or descending order (9 participants each). Placebo was scheduled quasi-randomly. During sessions volunteers used eyeshades and were instructed to direct their attention inward. Volunteers completed questionnaires assessing effects immediately
after and 1 month after each session, and at 14 months follow-up.
Results—Psilocybin produced acute perceptual and subjective effects including, at 20 and/or 30 mg/70 kg, extreme anxiety/fear (39% of volunteers) and/or mystical-type experience (72% of volunteers). One month after sessions at the two highest doses, volunteers rated the psilocybin experience as having substantial personal and spiritual significance, and attributed to the experience sustained positive changes in attitudes, mood, and behavior, with the ascending dose sequence showing greater positive effects. At 14 months, ratings were undiminished and were consistent with changes rated by community observers. Both the acute and persisting effects of
psilocybin were generally a monotonically increasing function of dose, with the lowest dose showing significant effects.
Conclusions—Under supportive conditions, 20 and 30 mg/70 kg psilocybin occasioned mystical-type experiences having persisting positive effects on attitudes, mood and behavior. Implications for therapeutic trials are discussed.
Carhart-Harris et al. (2012) - Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin
Psychedelic drugs have a long history of use in healing ceremonies, but despite renewed interest in their therapeutic potential, we continue to know very little about howthey work in the brain. Here we used psilocybin, a classic psychedelic found in magic mushrooms, and a task-free functional MRI (fMRI) protocol designed to capture the transition from normalwaking consciousness to the psychedelic state. Arterial spin labeling perfusion and blood-oxygen level dependent (BOLD) fMRI were used to map cerebral blood flow and changes in venous oxygenation before and after intravenous infusions of placebo and psilocybin. Fifteen healthy volunteers were scanned with arterial spin labeling and a separate 15 with BOLD. As predicted, profound changes in consciousness were observed after psilocybin, but surprisingly, only decreases in cerebral blood flow and BOLD signal were seen, and these were maximal in hub regions, such as the thalamus and anterior and posterior cingulate cortex (ACC and PCC). Decreased activity in the ACC/medial prefrontal cortex (mPFC) was a consistent finding and the magnitude of this
decrease predicted the intensity of the subjective effects. Based on these results, a seed-based pharmaco-physiological interaction/functional connectivity analysis was performed using a medial prefrontal seed. Psilocybin caused a significant decrease in the positive coupling between the mPFC and PCC. These results strongly
imply that the subjective effects of psychedelic drugs are caused by decreased activity and connectivity in the brain's key connector hubs, enabling a state of unconstrained cognition.
Griffiths et al. (2016) - Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial
Cancer patients often develop chronic, clinically significant symptoms of depression and anxiety. Previous studies suggest that psilocybin may decrease depression and anxiety in cancer patients. The effects of psilocybin were studied in 51 cancer patients with life-threatening diagnoses and symptoms of depression and/or anxiety. This randomized, double-blind, cross-over trial investigated the effects of a very low (placebo-like) dose (1 or 3 mg/70 kg) vs. a high dose (22 or 30 mg/70 kg) of psilocybin administered in counterbalanced sequence with 5 weeks between sessions and a 6-month follow-up. Instructions to participants and staff minimized expectancy effects. Participants, staff, and community observers rated participant moods, attitudes, and behaviors throughout the study. High-dose psilocybin produced large decreases in clinician- and self-rated measures of depressed mood and anxiety, along with increases in quality of life, life meaning, and optimism, and decreases in death anxiety. At 6-month follow-up, these changes were sustained, with about 80% of participants continuing to show clinically significant decreases in depressed mood and anxiety. Participants attributed improvements in attitudes about life/self, mood, relationships, and spirituality to the high-dose experience, with >80% endorsing moderately or greater increased well-being/life satisfaction. Community observer ratings showed corresponding changes. Mystical-type psilocybin experience on session day mediated the effect of psilocybin dose on therapeutic outcomes.
Ross et al. (2016) - Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial
Background: Clinically significant anxiety and depression are common in patients with cancer, and are associated with poor psychiatric and medical outcomes. Historical and recent research suggests a role for psilocybin to treat cancer-related anxiety and depression.
Methods: In this double-blind, placebo-controlled, crossover trial, 29 patients with cancer-related anxiety and depression were randomly assigned and received treatment with single-dose psilocybin (0.3 mg/kg) or niacin, both in conjunction with psychotherapy. The primary outcomes were anxiety and depression assessed between groups prior to the crossover at 7 weeks.
Results: Prior to the crossover, psilocybin produced immediate, substantial, and sustained improvements in anxiety and depression and led to decreases in cancer-related demoralization and hopelessness, improved spiritual wellbeing, and increased quality of life. At the 6.5-month followup, psilocybin was associated with enduring anxiolytic and anti-depressant effects (approximately 60–80% of participants continued with clinically significant reductions in depression or anxiety), sustained benefits in existential distress and quality of life, as well as improved attitudes towards death. The psilocybin-induced mystical experience mediated the therapeutic effect of psilocybin on anxiety and depression.
Conclusions: In conjunction with psychotherapy, single moderate-dose psilocybin produced rapid, robust and enduring anxiolytic and anti-depressant effects in patients with cancer-related psychological distress.
Carhart-Harris et al. (2016) - Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study
Background Psilocybin is a serotonin receptor agonist that occurs naturally in some mushroom species. Recent studies have assessed the therapeutic potential of psilocybin for various conditions, including end-of-life anxiety, obsessive-compulsive disorder, and smoking and alcohol dependence, with promising preliminary results. Here, we aimed to investigate the feasibility, safety, and effi cacy of psilocybin in patients with unipolar treatment-resistant depression.
Methods In this open-label feasibility trial, 12 patients (six men, six women) with moderate-to-severe, unipolar, treatment-resistant major depression received two oral doses of psilocybin (10 mg and 25 mg, 7 days apart) in a supportive setting. There was no control group. Psychological support was provided before, during, and after each session. The primary outcome measure for feasibility was patient-reported intensity of psilocybin's eff ects. Patients were monitored for adverse reactions during the dosing sessions and subsequent clinic and remote follow-up. Depressive symptoms were assessed with standard assessments from 1 week to 3 months after treatment, with the 16-item Quick Inventory of Depressive Symptoms (QIDS) serving as the primary effi cacy outcome. This trial is registered with ISRCTN, number ISRCTN14426797.
Findings Psilocybin's acute psychedelic eff ects typically became detectable 30–60 min after dosing, peaked 2–3 h after dosing, and subsided to negligible levels at least 6 h after dosing. Mean self-rated intensity (on a 0–1 scale) was 0·51 (SD 0·36) for the low-dose session and 0·75 (SD 0·27) for the high-dose session. Psilocybin was well tolerated by all of the patients, and no serious or unexpected adverse events occurred. The adverse reactions we noted were transient anxiety during drug onset (all patients), transient confusion or thought disorder (nine patients), mild and transient nausea (four patients), and transient headache (four patients). Relative to baseline, depressive symptoms were markedly reduced 1 week (mean QIDS diff erence –11·8, 95% CI –9·15 to –14·35, p=0·002, Hedges' g=3·1) and 3 months (–9·2, 95% CI –5·69 to –12·71, p=0·003, Hedges' g=2) after high-dose treatment. Marked and sustained improvements in anxiety and anhedonia were also noted.
Interpretation This study provides preliminary support for the safety and efficacy of psilocybin for treatment-resistant depression and motivates further trials, with more rigorous designs, to better examine the therapeutic potential of this approach.
Carhart-Harris et al. (2017) - Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms
Psilocybin with psychological support is showing promise as a treatment model in psychiatry but its therapeutic mechanisms are poorly understood. Here, cerebral blood flow (CBF) and blood oxygen-level dependent (BOLD) resting-state functional connectivity (RSFC) were measured with functional magnetic resonance imaging (fMRI) before and after treatment with psilocybin (serotonin agonist) for treatmentresistant depression (TRD). Quality pre and post treatment fMRI data were collected from 16 of 19 patients. Decreased depressive symptoms were observed in all 19 patients at 1-week post-treatment and 47% met criteria for response at 5 weeks. Whole-brain analyses revealed post-treatment decreases in CBF in the temporal cortex, including the amygdala. Decreased amygdala CBF correlated with reduced depressive symptoms. Focusing on a priori selected circuitry for RSFC analyses, increased RSFC was observed within the default-mode network (DMN) post-treatment. Increased ventromedial prefrontal cortex-bilateral inferior lateral parietal cortex RSFC was predictive of treatment response at 5-weeks, as was decreased parahippocampal-prefrontal cortex RSFC. These data fill an important knowledge gap regarding the post-treatment brain effects of psilocybin, and are the first in depressed patients. The post-treatment brain changes are different to previously observed acute effects of psilocybin and other 'psychedelics' yet were related to clinical outcomes. A 'reset' therapeutic mechanism is proposed.
Roseman et al. (2018) - Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression
Introduction: It is a basic principle of the "psychedelic" treatment model that the quality of the acute experience mediates long-term improvements in mental health. In the present paper we sought to test this using data from a clinical trial assessing psilocybin for treatment-resistant depression (TRD). In line with previous reports, we hypothesized that the occurrence and magnitude of Oceanic Boundlessness (OBN) (sharing features with mystical-type experience) and Dread of Ego Dissolution (DED) (similar to anxiety) would predict long-term positive outcomes, whereas sensory perceptual effects would have negligible predictive value.
Materials and Methods: Twenty patients with treatment resistant depression underwent treatment with psilocybin (two separate sessions: 10 and 25mg psilocybin). The Altered States of Consciousness (ASC) questionnaire was used to assess the quality of experiences in the 25mg psilocybin session. From the ASC, the dimensions OBN and DED were used to measure the mystical-type and challenging experiences, respectively. The Self-Reported Quick Inventory of Depressive Symptoms (QIDS-SR) at 5 weeks served as the endpoint clinical outcome measure, as in later time points some of the subjects had gone on to receive new treatments, thus confounding inferences. In a repeated measure ANOVA, Time was the within-subject factor (independent variable), with QIDS-SR as the within-subject dependent variable in baseline, 1-day, 1-week, 5-weeks. OBN and DED were independent variables. OBN-by-Time and DED-by-Time interactions were the primary outcomes of interest.
Results: For the interaction of OBN and DED with Time (QIDS-SR as dependent variable), the main effect and the effects at each time point compared to baseline were all significant (p = 0.002 and p = 0.003, respectively, for main effects), confirming our main hypothesis. Furthermore, Pearson's correlation of OBN with QIDS-SR (5 weeks) was specific compared to perceptual dimensions of the ASC (p < 0.05).
Discussion: This report further bolsters the view that the quality of the acute psychedelic experience is a key mediator of long-term changes in mental health. Future therapeutic work with psychedelics should recognize the essential importance of quality of experience in determining treatment efficacy and consider ways of enhancing mystical-type experiences and reducing anxiety.
Carhart-Harris et al. (2018) - Psilocybin with psychological support for treatment-resistant depression: six-month follow-up
Rationale Recent clinical trials are reporting marked improvements in mental health outcomes with psychedelic drug-assisted psychotherapy.
Objectives Here, we report on safety and efficacy outcomes for up to 6 months in an open-label trial of psilocybin for treatmentresistant depression.
Methods Twenty patients (six females) with (mostly) severe, unipolar, treatment-resistant major depression received two oral doses of psilocybin (10 and 25 mg, 7 days apart) in a supportive setting. Depressive symptoms were assessed from 1 week to 6 months post-treatment, with the self-rated QIDS-SR16 as the primary outcome measure.
Results Treatmentwas generallywell tolerated. Relative to baseline, marked reductions in depressive symptoms were observed for the first 5 weeks post-treatment (Cohen's d = 2.2 at week 1 and 2.3 at week 5, both p < 0.001); nine and four patientsmet the criteria for response and remission at week 5. Results remained positive at 3 and 6 months (Cohen's d = 1.5 and 1.4, respectively, both p < 0.001). No patients sought conventional antidepressant treatment within 5 weeks of psilocybin. Reductions in depressive symptoms at 5 weeks were predicted by the quality of the acute psychedelic experience.
Conclusions Although limited conclusions can be drawn about treatment efficacy from open-label trials, tolerability was good, effect sizes large and symptom improvements appeared rapidly after just two psilocybin treatment sessions and remained significant 6 months post-treatment in a treatment resistant cohort. Psilocybin represents a promising paradigm for unresponsive depression that warrants further research in double-blind randomised control trials.
Last edited by eggsprog; 08-09-2020, 09:02 PM. Reason: Formatting
Also, if anyone wants a specific study that is mentioned in one if these articles, let me know and I'll try to get it for you.
Lots are available in some form via Google Scholar, depending on the journal it was published in.
I moved my other psilocybin research oriented thread to here and just merged the whole thread into one post. I didn't get a prompt on how to order the posts, so apparently it hoisted it below the Op.

redpajama_set_name: RedPajamaCommonCrawl


text:
В основу устройства Международной космической станции (МКС) заложен модульный принцип. Сборка МКС происходит путём последовательного добавления к комплексу очередного модуля или блока, который соединяется с уже доставленным на орбиту.

На конец 2021 года в состав станции входит 16 основных модулей: российские — «Заря», «Звезда», «Поиск», «Рассвет», «Наука», «Причал»; американские — «Юнити», «Дестини», «Квест», «Гармония», «Транквилити», «Купола», «Леонардо»; европейский «Коламбус»; японский «Кибо» (состящий из двух частей); экспериментальный модуль «BEAM», три стыковочных адаптера IDA, четыре пары больших солнечных панелей американского сегмента, установленных на ферменной конструкции. Масса МКС составляет около 420 тонн. Размеры — 108,4 на 74 метра.

Собирать МКС начали в ноябре 1998 года. Первым на орбиту российской ракетой «Протон» был отправлен модуль «Заря», а через две недели шаттл Endeavour доставил к нему американский модуль «Unity» и два стыковочных адаптера. Строительство полной станции потребовало более 40 полётов.

В статье описывается последовательность сборки основных компонентов МКС.

График сборки
Компоненты, выделенные жирным шрифтом, уже являются частью станции.
Все перечисленные ниже числа являются ориентировочными и показывают только «стартовые» значения.

Планируемые компоненты

Фотогалерея этапов сборки МКС

См. также
 Международная космическая станция

Примечания

Ссылки
 РКК «Энергия»: «Этапы развёртывания МКС»
 Пилотируемая космонавтика в цифрах и фактах: Хронология сборки орбитального комплекса МКС
 «Назад в будущее»: «Космический дом — Международная космическая станция»
 ESA: Building the ISS
 Unofficial Shuttle Launch Manifest
 ISS Assembly Animation

Международная космическая станция

redpajama_set_name: RedPajamaWikipedia


Lloyd's US - New York - Lloyd's - The world's specialist insurance market. Also known as Lloyd's of London; is a market where members join together as syndicates to insure risks.
Hank is responsible for Lloyd's market development activities in the US, Canada and Latin America. From offices in Atlanta, Boston, Chicago, Dallas, Frankfort KY, New York, Montreal, Toronto, Bogota, Mexico City and Rio de Janeiro, Lloyd's is actively engaged in educational and marketing outreach to retail, wholesale and reinsurance intermediaries, risk managers, managing general agents, risk management programs at colleges & universities and other stakeholders in the Lloyd's market.
Hank has more than 35 years of experience in the insurance industry and has held a range of underwriting, client management and leadership positions in the United States and Europe at Chubb, Johnson & Higgins, Marsh and HRH.
Hank received his BA from the University of California, Berkeley and has completed an executive leadership program at The Wharton School. He's a member of the Board of Overseers at St. John's University's School of Risk Management and is on the boards of the Insurance Information Institute and Insurance Industry Charitable Foundation (NY/Northeast Division).
With more than 55% of Lloyd's global premium in 2018, the Americas region is Lloyd's largest market for insurance (E&S in the US) and reinsurance. In addition to market development, Lloyd's colleagues in the Americas provide media relations and regulatory support to the managing agents / syndicates and operational oversight of the licensed platforms in Illinois, Kentucky, the USVI and our Lineage system in Montreal.
As General Counsel, Lloyd's America, Joe oversees a wide range of US legal issues, including legislative and regulatory policy, and acts as Lloyd's key liaison with US regulators, legislators and government officials on a variety of matters.
Joe joined Lloyd's in 2000. He has worked in the insurance industry, in private practice and in-house, for over 25 years. Most recently, Joe was Vice President and General Counsel for a division of American International Group.
Please be aware that Lloyd's New York office is not authorised as the agent for service-of-process or notice-of-claim with respect to policies of insurance written at Lloyd's. Please refer to the contact as stated in the policy or insurance certificate.


private access road that serves the south shore of Lorton Lake.
hundreds of miles of maintained atv and snowmobile trails within minutes of the property!
fishing opportunities. LINK TO LEWIS COUNTY TRAILS MOVIE GALLERY .
The property will be sold by warranty deed free and clear with no liens or encumbrances.
may be available at owner's discretion.
Sold Thanks Don & Kimberly !


As IT outsourcing moves well into its third decade, IT decision makers have made great strides in maturity, managing to avoid some common and costly pitfalls of the practice.
Companies are struggling to compete in the dynamic digital era, so it's only natural that they look to their IT service providers for help. The only problem is that it's nearly impossible to write an RFP for disruption.


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Our mission is to enable millions more to cycle. As independent experts we are able to offer a range of impartial advice, guides, reviews, inspiration and routes to help you experience the joy of cycling. We also have community projects and a network of thousands of clubs, groups and events.
Our newest cycling route
Follow in the chariot tracks of the trailblazing warrior queen Boudicca on this bikepacking trail around Norfolk
Rebellion Way
For over 140 years, Cycling UK has campaigned to make cycling safe and accessible for everyone. Every year, thousands of people support our campaigns and together we achieve real change for cyclists. We help make our roads safer for all and improve access to the outdoors.
Take action for cycling
Join the Cycle Advocacy Network
Join CAN our network of local campaigners and speak up for cycling in your neighbourhood and wider community.
There are many different ways you can get involved with Cycling UK and help us support many more people to cycle. Join, donate, volunteer or be involved in our inspiring campaigns and projects.
Our volunteers make the world better by bike by carrying out tasks to encourage others to cycle more.
Cycling UK offers a range of cycling-related services to support and advise our members, the wider cycling community and employers. If you are looking for cycling insurance, training courses, help to run an event or if you'd like to be a Cycle Friendly Employer we can help.
Support for employers and employees
The science overwhelmingly shows that commuters who cycle to work are healthier, happier and more productive.
Workplace support
Cycling UK is more than just a membership charity, which provides you with excellent insurance, information and a magazine. We run a range of projects, groups and programmes across all nations of the UK to encourage people to cycle.
Support Cycling UK
Your membership will enable us to have a louder voice to lobby government, campaign for improved rights and inspire millions more people to cycle.
Cycling Dumfries
Cycling UK Affiliated Group
Welcome to Cycling Dumfries, the campaign to improve cycling conditions in Dumfries and the surrounding area. We are an affiliated group of CTC.
Contact person by email
https://cyclingdumfries.wordpress.com/
https://www.facebook.com/cyclingdumfries/
https://twitter.com/CyclingDumfries
https://www.instagram.com/cyclingdumfries/
Leisure/Touring rides
Campaigning group
The pedal bicycle, or so legend has it, was invented in Dumfries and Galloway by Kirkpatrick Macmillan. And it's no wonder that he did, for the county has some of the best cycling in the country – from the mountain biking trails of the 7Stanes to the miles and miles of quiet rural roads beloved of cycle tourers and racers.
And yet when you look at Dumfries and its surroundings, relatively few people are using bikes simply to get about, depending instead on their cars.
We're hoping to change that and bring the bike back right into the heart of the community where it was born. Cycling Dumfries is a new kind of cycling campaign – not just for the people who already cycle, and not just for the racers or the mountain bikers or tourers. It's for everybody who might like to use a bike, or use their bike more, to get to work, school, the shops, the pub, or just out and about.
We campaign for better cycling conditions in and around the town. Some of the things we've done include writing to Councillors, working with Dumfries and Galloway Council on strategies and policies, running the Dumfries Bike Breakfast and demonstrating by cycling to COP26 in Glasgow. We're always keen for more people to join our small campaign group and welcome all comers, whatever your background. You don't even have to have a bike! If this sounds like something you might like to get involved in, please contact us. We usually meet once a month, either virtually or in person.
To find out more visit https://cyclingdumfries.wordpress.com/
Information about the group rides
We run various ride programmes throughout the year.
These include summer rides in July and August for beginners and families, starting from 3 miles for families and anyone new to cycling.
They are safe escorted rides using traffic-free paths and quiet roads wherever possible, lasting no longer than a couple of hours and starting from 3 miles. They're suitable for all the family and particularly beginners, or anyone who just wants to ride at a gentle pace in congenial company. See https://cyclingdumfries.wordpress.com/summer-rides/ for more details.
Our monthly curiosity rides programme of accessible sociable rides explores the quiet roads and cycle routes around Dumfries.
They're longer than our summer ones – about 20-25 miles – and a wee bit hillier, but they'll always be taken at an easy pace with an emphasis on taking time to discover some hidden delights of the area rather than just putting in the miles. Oh, and usually stopping for lunch…
So if the distance seems a bit much for you, just think of it as two 10-12 mile rides – much more doable! See https://cyclingdumfries.wordpress.com/autumn-winter-rides/ for more details.
We also run work parties including leaf clearing, bramble lopping and litter picking on the dedicated walking and cycling routes. And sometimes we run extra ride programmes so check out https://cyclingdumfries.wordpress.com/whats-going-on-2/ for all the latest events and activities.


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Nike Total 90 Tracer Premier League Football
No Comments on Nike Total 90 Tracer Premier League Football
Nike is back with its Total 90 range of football with the ball – Tracer.
Nike Total 90 Tracer PL Football
This ball would be the official ball of the Premier League. According to Nike "This innovative ball matches your level of play with high-performance benefits to help you beat the other side. Made with advanced Geo-Balanced II technology, the T90 Tracer PL features geometrically precise panels to distribute pressure evenly across the surface. That means you'll get a more consistent, powerful strike, regardless of where you hit the ball."
The ball looks great with a new design for the season.
More on Nike Football.com
Tags football, nike
Nike T90 Ascente Strike EPL Football
No Comments on Nike T90 Ascente Strike EPL Football
Nike has unveiled the new football for the 09-10 Barclays Premier League season, the Nike T90 Ascente Strike EPL Football. The T90 Ascente has the following improvements over the previous football.
360 Sweet Spot
Longer Range
Inceased Visibility
Higher Accuracy
Greater Speed
Nike claims that the ball has been "lab-tested" & "wind-tunnel" tested for unrivaled flight and accuracy. Check out more about the T90 Ascente on Nike Football.
Nike Mercurial Vapor IV Rosa – A Pink Boot!
1 Comment on Nike Mercurial Vapor IV Rosa – A Pink Boot!
A "Pink" football boot? See it to believe it!
I have seen red Mercurial Vapors, orange Mercurial Vapors worn by Cristiano Ronaldo, but pink! Thats a first! And I'm not sure if I liked it or not. But yeah Nike does manage to make boots in all sorts of colors, especially the Mercurial Vapors, and the T90 Laser.
NikeFootball.com
Tags football, football boot, nike
Nike T90 Laser II
Post date July 1, 2008
2 Comments on Nike T90 Laser II
The new avatar of the famous Nike T90 series is out and its even better. It now has a even better "sweet spot" and a new "V-twin lacing" for better contact. They again have some color combos like the one in the pic below featuring a black and green combination, then they also have white/red combo, black/orange. Read more about the Nike T90 Laser II. We'll get to see Wayne Rooney and Fernando Torres sporting these shoes in the Premier League. The boot is really a mean looking thing, wonder what havoc Rooney and Torres are gonna wreak in the Premier League now 😛
There is also a new ball called Nike T90 Laser II Omni. Its a new looking ball with a very new design. Like Nike puts it "The revolutionary T90 Omni Ball provides a 360-degree sweet spot, increased visibility and cutting-edge panel architecture, there's never been a more consistently accurate Nike ball." It will feature in the Premier League's new season as well.
Spain wins UEFA Euro 2008
No Comments on Spain wins UEFA Euro 2008
Spain's wait for a major success is finally over as they end the 44 years barren run with a 1-0 win over Germany in the Euro 2008 finals in Vienna. Fernando Torres provided the only goal after 33 minutes. They started out as favorites and justified their status as among the best in Europe. They played well, rose to the occasion and beat Germany convincingly in the finals to be the champions. I was disappointed by Germany as they failed to score a goal even with a bunch of good attacking players. They looked out of ideas and weren't in high tempo. Spain were much better and played some good football and were the deserving winners.
With this the Euro 2008 also comes to and end, and which means I can now sleep on time, which wasn't the case ever since the Euro had started, thanks to the late kick-off timings here in India. But it was worth it I guess. We saw some great football action, some new talented players rose to the limelight, some disappointed, but in the end the football fan enjoyed what was a memorable Euro Cup. I missed England a lot. The likes of Wayne Rooney, David Beckham, Steven Gerrard not present in a major tournament is a bit of a turn off, but Russia, who thumped England to reach the tournament, justified their qualification by plaing some outstand football, and beating the favorites Netherlands convincingly. Marvo Van Basten's side played some good attacking football themselves before being outclassed and outplayed by Russia. France had a miserable time and they need to give a hard look down the line to see where they were wrong. Italy had a decent run until they lost out to Spain on penalties. Portugal too were favorites to win it but couldn't get past Germany. Germany on the other hand were not really in good form in the tournament but still managed to get into the finals. Turkey were the kind of comebacks as they played some thrilling football and managed to get into the quarter-finals. Croatia were again very good, and they deserved to play in the quarter-finals, but couldn't do so.
Players wise we saw some good crop of talented players. Russian duo of Roman Pavlyuchenko and Andrei Arshavin emerged as a great force for Russia's success. David Villa was the top scorer in the tournament and was a player to watch for Spain. Ruud van Nistelrooy was still in best of form and played some good football. There were some big disappointments as well. The French team dissappointed big time. Much was expected from Karim Benzema but he couldn't do much on the field. Theiry Henry too didn't make a big impact for the French. Frank Ribéry was somewhat better for Les Blues. Fàbregas played outstanding for Spain, he was a player who deserved to play in the finals. There were still a lot of other players who played their part, like the Turks, the Croatians, they all played some superb football, and got some glory for their teams. But in the end there is only one winner and that was Spain.
So now no football for a while now, until August when the new season of English Premier League kicks off, which promises to be a even more action packed than the last season. Will write a preview for the season, so watch this space.
Tags euro 2008, football
UEFA Euro 2008 Preview
No Comments on UEFA Euro 2008 Preview
A SportZForumZ exclusive Report, by Varun K R:-
So after a big wait of 4 years, the Euro is back! Something that always lives up to the hype it gets, it's also one of the tournaments where amazing football is on display, probably because of the fact that one bad game could mean another 4 year wait!
Continue reading "UEFA Euro 2008 Preview"
Tags euro 2008, football, Sports
Nike Total 90 Laser
8 Comments on Nike Total 90 Laser
I went to the mall on Sunday, and I saw that Nike had some new range of football boots. The new Total 90, Tiempo, the Ronaldinho 10R, (the Mercurial were still missing) and amongst them there was one which attracted special attention from me. They were the T90 Lasers!!!
Here is the official word about it:
"The Nike Total 90 Laser is the new boot choice of England and Manchester United"s Wayne Rooney, creating a revolutionary enhancement of the Total 90 series.
Applying the learning from sports like golf or tennis, the expanded Sweet Spot on the Nike Total 90 Laser allows the athlete to maximise shooting and passing accuracy through better boot to ball alignment and targeting.
Unique precision rings create optimum trajectrory, spin and distance control. Twisted medial rings provide more agggressive contact, enhancing ball spin and swerve opportunities."
I could recognize those bright yellow boots anywhere! I just went and picked it up in my hands and boy it was amazing! I've been viewing the Nike site quite often of late and saw the new boots there, but never thought when I would ever see it in real, but there it was. I was delighted to see and touch them! It had amazing quality finish, the sole had a good pack of studs and blades. The uppers were just oozing quality. Awesome sweet spot, I wish I could have them, but the price tag was way beyond my reach. Anyways was a great boot to have a look at.
Please do visit the Nike site for more cool videos and stuff about the T90s. The "Put it where you want it" Video is great, with the kick showed in various angles. Do watch it!
www.nikefootball.com
Some Pics:


I sometimes have the opportunity to take a class on a field trip to a local park. As a follow-up activity, I like to ask students to get creative and come up with ideas for their own parks. They might, for example, create an aquarium-themed park, a teenager-only park, a trampoline park, or a food park complete with pizza-shaped slides. The more unusual, the better!
Brainstorm a list of park-related vocabulary, and create a class list of new words.
Divide your class into small groups.
Introduce the topic. Display the slide above, or create a list of questions of your own that you would like students to respond to. Give them time to discuss.
(Optional, but recommended) Hand out poster paper, and instruct your groups to draw pictures of their new park.
Give students time to prepare presentations for their classmates. Tell them that they should be able to describe their picture, and explain why their idea deserves to win the new park competition.
(Also optional) After all groups have presented, take a class survey: Which group should win the competition, and why?
If you like this type of activity, check out my Creative Tasks section for more like it.
And if you tried this out in your class, I'd love to know how it worked out for you. Please take a moment to tell me about it in the Comment section!
Most ESL textbooks include a chapter on food, and in my experience, that chapter is usually everyone's favorite. Students of all levels are able to talk about what they like to eat and describe the foods that they miss from back home. I usually use the following create-it task at the end of a food unit to give students a chance to practice new vocabulary or grammar structures.
I've used variations of this creative activity with Beginner to Intermediate level students, and they always seem to enjoy it. It can be surprisingly easy to set up, and doesn't require tons of advance planning. If you have the technology available, you could display the slide above, or create one with your own questions. If you don't, you can simply write your questions on the board.
Divide your students into small groups and tell them that they are business partners. They have decided to open up a little restaurant. Because they are on a budget, they have to keep the menu small. (I usually limit it to 3-5 items because I find that bigger menus can be overwhelming and take a long time to present.) You might brainstorm some possible restaurant themes as a whole class, and list them on the board.
In groups, have students respond to the questions on the board and prepare a presentation for the class. You might have them create a physical menu or poster to show the class, although I don't often do that with my adult students.
Groups make their presentations, and everyone gets really hungry.
If your students created menus, this is the perfect time to do a lesson on how to order food. First, brainstorm useful expressions for ordering at a restaurant, and/or present a simple restaurant dialogue. Them allow them to walk around, "visit" each other's restaurants, and practice ordering.


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Share this Story: Blood for weed? How companies are thinking outside of the box to mark this 4/20
Blood for weed? How companies are thinking outside of the box to mark this 4/20
This 4/20 is all about sparking for trees, taking flight, giving back and getting organized.
Denver-based cannabis accessory brand Blazy Susan is partnering with One Tree Planted this 4/20. / Photo by Blazy Susan, Instagram
This coming week is all about 4/20, whether that be supporting the environment, building a new business through a lofty contest, giving back to the community or advocating for safe and secure working conditions for all industry employees.
How this Vancouver company's plan to be a game-changer hinges on human trials of cannabis vapes
Slashing weed jobs, diversifying the industry and identifying the skunk in the room
Righting wrongs, advancing research and finding the right person for the job
Blood for weed? How companies are thinking outside of the box to mark this 4/20 Back to video
Spark up a doobie for the environment
Blazy Susan estimates that, as part of the initiative, more than 1,000 new trees will be planted. / Photo by Blazy Susan, Instagram
Denver-based cannabis accessory brand Blazy Susan is going au naturel this 4/20 by partnering with One Tree Planted so that each order placed on its website during the month of April, which is Earth Month, translates to another tree being planted.
Blazy Susan estimates that, as part of the initiative, more than 1,000 new trees will be planted, contributing to One Tree Planted's focus on global reforestation.
Beyond directing funds to One Tree Planted, brand staff will be participating at an in-person planting event in Denver.
Blazy Susan offers rolling papers (including pink ones) , pre-rolled cones, smoking accessories, dabbing accessories, bundles and rolling trays ( even a spinning one) . Customers can save 20 per cent on EVERYTHING at blazysusan.com when using the code, April, at checkout, notes an Instagram post.
Whatever the differences among those who make up the Blazy Susan team, "there's one thing we all have in common — a deep love and appreciation for Earth and our environment," creating a healthier climate and promoting biodiversity, reports the company.
COVID-19 restrictions will keep members of the public at bay for the in-person planting event. Still, the hope is "this will be the start of a long and meaningful partnership between Blazy and One Tree Planted and that we will be able to plant thousands of trees in the coming years."
B.C. pot shop takes flight with 'Fly & Dine' contest
The contest kicked off Apr. 4, when the store opened its doors, until — no surprises here — Apr. 20. / Photo by Flight Cannabis, Instagram
Flight Cannabis Co. is soaring to new heights with a 4/20 contest that will see the recently opened Nanaimo, B.C. store gift some weed-loving winner with a fly and dine package for four people.
The contest kicked off Apr. 4, when the store opened its doors, and runs until — no surprises here — Apr. 20. Up for grabs is the Fly & Dine package that features a float plane tour of Nanaimo's waterfront and the Southern Gulf Islands, including Newcastle Island Provincial Park, before coming back to earth to be treated to a fine dining experience in the city's historic downtown.
Those wanting to take to the skies need only head over to the store's website to subscribe and enter by Apr. 20, with the winner being notified via email and announced on social media. No purchase is necessary, but the winner must be at least 19 and be able to pick up their heavenly prize at the store.
Flower, pre-rolls, capsules, oils and topicals, drinks and edibles, vapes, concentrates and seeds are all on the menu at the store, designed to welcome, engage and learn , with a focus on B.C. producers.
Blood for weed? U.S. dispensary holds blood drive
The companies wanted to give back to the community by holding the blood drive. / Photo by ViktorCap / iStock / Getty Images Plus
The Oasis Cannabis dispensary in Chandler, Ariz. could think of no better way to mark the life-affirming vibe that is 4/20 than by providing cannabis to all those who provide life-saving blood on the busiest weed day of the year: Apr. 20.
Sponsored by Oasis Cannabis, Copia and OGeez!, blood drive participants will have access to more than just feeling good about helping their community.
Extra goodies for all participants 21 or older will include a US$10 Amazon e-gift card, a free 100 mg pack of OGeez! gummies and a one-gram Oasis hybrid pre-roll, according to Oasis Cannabis.
"Normally, 420 is simply filled with discounts and giveaways," but the companies wanted to give back to the community by holding the blood drive. With the new adult market in Arizona , the company anticipates this 4/20 will be the biggest one yet.
Being a weed lover, a prospective participant may have some THC in their systems. That's okay. People can still donate blood since "all donated blood goes through a post-process filtration to ensure the recipient is getting clean platelets or cells," Oasis Cannabis reports.
Copia/OGeez! is the only medical weed company in the U.S. with an official partnership with the American Red Cross to support blood donations and host on-site drives, the company website adds.
Participants will need to register using the code oasiscopia.
Ontario group campaigns for fair wages and safe working conditions
The United Weed Workers reports it has heard stories from industry workers about a lack of personal protective equipment during COVID, among other concerns. / Photo by nikom1234 / iStock / Getty Images Plus
Working conditions for those in the cannabis industry will take centre stage with a new campaign that kicks off on Apr. 20.
According to the CBC , a group of cannabis workers in Hamilton, Ont. sees 4/20 as the perfect time to bring greater awareness to the industry's working conditions and to inform individuals about their rights.
Under Ontario's Occupational Health and Safety Act, workers have the right to participate, the right to know and the right to refuse work. The act "prohibits reprisals being taken against workers who exercise these rights."
The United Weed Workers reports it has heard stories from industry workers about a lack of personal protective equipment " during COVID , their companies operating without a proper robbery and violence prevention strategy and promises of wages and benefits that do not manifest through proper company administration," according to the CBC .
The cannabis industry covers many different sorts of jobs, from cultivation to retail. Employees at some retail stores have been able to successfully organize, the United Weed Workers reports, with one B.C. store recently unionizing and two stores in Hamilton voting to unionize . That said, "in the agricultural sector, workers have been unable to organize despite their efforts due to government intervention and migrant labour issues," the CBC cites the group as noting.
"We campaign for fair wages, safe conditions + sustainable cannabis for all," notes the group's Twitter feed .


On 17/05/2018, Punjab State e - Governance Society announced Job notification to hire candidates who completed B.Tech/B.E, M.Sc, MCA, CA for the position of Web Developer, Dot Net Developer, Finance Manager.
1. Essential Qualification / Eligibility: B.E. in IT or Computer Science / B. Tech. in IT or Computer Science / M.Sc. in IT or Computer Science / MCA from recognized university or institution with minimum 60% in aggregate in each case.
2.Experience: Minimum 4 years relevant experience in web development / designing, database handling, web hosting and maintenance using ASP.Net and MS SQL Server. The candidate is required to have hands on experience of Ajax, HTML/Boot strap/ CSS and J-query skill.
3. Preferable: An additional experience in application software testing will be preferred.
Which Government U like in Punjab?


With barely three weeks to go before my trip, it's time to ditch my apartment. After a lightning-fast ninety days in my new place, my sub-lease is up and I'll be staying with family for the final three weeks before I go. The summer flew by. At least I know where I'm moving to, this time.
True to my procrastinatory nature, I've left myself far too little time to pack and clean up in a calm, relaxed manner and still get my day-to-day rounds done. To top it off, I was only able to arrange a moving vehicle for Friday evening alone. Poor planning strikes again.
So in the interest of being somewhat on top of things before the weekend, I'm not going to publish a normal Thursday article today. Instead, I'll direct your attention to the brand new Best of Raptitude page.
It lists the ten articles most popular in Raptitude's first six months, along with my ten favorites. If you haven't read them all, then pick one and pretend I wrote it last night.
By Monday I will be moved, and back to your regular programming.
Awesome, David! I can't wait to hear of your travels. I actually want to read 88 Truths of Life again. It really captures the essence of your writing.
.-= John´s last blog ..Why Quality is Far More Important than Quantity =-.
Good luck with the move this weekend. And exciting times lie in front of you, very awesome!!
.-= Lance´s last blog ..If It Matters, Choose to Show Up =-.
This is so exciting! I can't believe October is upon us already. I remember when you first told me about your adventure, that it seemed so far off in the future… and here it is! In a weird twist of fate, we are also starting OUR adventure in October. This promises to be an interesting autumn.
Good luck with your transition, d. Remember that, no matter how crazy stuff gets, we will all still be here (pretending) when you get sorted out.
.-= Lisis´s last blog ..When Life Knocks You Down =-.
Thanks Lisis. It sure has come quickly. I predict the best autumn ever, for both of us.
Have a great move! Thanks for pointing your top articles/posts!
.-= Dayne | TheHappySelf.com´s last blog ..How to Stop Procrastination…Now, Not Later. =-.
Thanks Dayne. This move shouldn't be too bad, I don't have a lot of stuff these days.
All the best with your travels David.
I'm originally from Auckland, an amazing city – easy access to the Bay of Islands, the Coromandel (try and get to HaHei/Cathedral Cove and New Chums if possible!), and the beautiful, rugged West coast beaches and Waitakere ranges.
I've only heard good things about Wellington, and it will be a great base for you to be able to access the South Island. The Abel Tasman coast track is magic and next on my list to do is the Routeburn track.
Although I've lived in London for the past 3 years I know that NZ will always be home, it really is special. I hope you have an amazing time, ka kite ano!!
Hi Anna. I do intend to visit the Coromandel, but I hadn't decided on specific destinations. Whitianga and Hahei are looking like strong possibilities.
Holy Moving Van, Batman! I can't believe how fast time flies.
Thanks the head's up notice, David. I actually like reruns when the programming is full of awesomeness. So, I'll be heading over to your "Best of Raptitude" page for another look.
.-= Lori´s last blog ..Start A Blog =-.
Yes, it is almost time. And the time still seems to be accelerating.
We are looking forward to post of your grand adventure. The next 3 weeks will pass quickly. It is difficult to select the 10 best posts. You put a great deal of thought and carefully crafted writing into all of them.
I'm actually building a separate but related blog to post about my trip. I don't want to inundate this blog with travel posts, so I'll keep them all there. I'll unveil it the week before I leave.
.-= Find yourself with a smile…´s last blog ..3 Methods For Finding Focus In Your Favorite Forum =-.
It went pretty smoothly because I don't have much stuff. I still have to clean the place though… tomorrow's job.


It's a good exercise for companies step outside of the box and a really take a look at their competition. It allows for a good level of intellectual honesty about one's position in the market and how they can combat their obstacles — as the adage goes, knowledge is power. With that, for your benefit, we put together a list of four common competitive obstacles to seed VCs.
This is one is a no-brainer, but it's important to be aware of your competitive surroundings. The VC landscape is very different today, there are many more funds to compete with than there was let's say five years ago. And although you may be sitting at the peak of your respective sector and geographic, there are many funds hungry for a piece of the action.
Some founders are able to leap past an institutional seed round and go straight to a multi-million dollar A-round where a larger VC puts in a large share of the capital. This can happen either because the founder can boost the company with his/her own resources to get further, or because the company (and team) is so captivating that a large fund can lead a series A right away. There are positive and negatives to this approach, but without a doubt, it's becoming more prevalent in today's startup universe.
High-quality institutional investors may be interesting in investing in a company at fair valuation, but that doesn't stop non-institutional investors from set terms 1.5 – 2 times higher than that valuation. Founders, more and more, are walking away from the smart money of institutional investors and settling for the same amount with less dilution.
A threat that always besets seed funds is whether or not a promising business hits a rough patch, and ends up going through a very dilutive financing. Most seed funds have significant follow-on capital, but not to the extremity of traditional venture funds. This really becomes a problem when times are tough. If a fund decides to reserve more capital for such follow-on, they either have to invest less in the seed and have less ownership to begin with, or raise a larger fund. Of course if you invest and own less, you run the risk of getting crammed down the ownership chain. If you raise more money as a firm, the bar to return the fund is now higher because you have more capital. You either have to have bigger gains than before to get the same performance, or you have to own more of your portfolio companies, which puts you right back at the beginning.
Being CEO of a startup is similar to being a new parent. Your peers see a clean and polished toddler with very proud parents. But we all know what goes on behind closed doors. Sleepless nights, constant supervision, stress, more stress and no time to attend to other relationships. You are a laden by this new creature.
When it's all said and done, parenting is incredibly rewarding, but it's very hard work and not for the faint of heart. And just as parenting isn't for everyone, being a startup CEO isn't always a good fit either.
If top talent lines up to work for someone, that person has got something worth paying attention to. Be careful though. Anyone could be CEO of super fast growing startup and attract great talent. So make sure it is the CEO who can attract talent, not just someone clinging to the fire at a hot company. As such, it's imperative to dig into the company's team and see what's turning the gears.
A good CEO can really stretch their rolodex, leading to a ton of benefits for the company. Shorten sales cycles, faster hiring times, quicker fundraising — the quicker a company scales, the quicker you get a return on your investment.
The CEO doesn't have to be the Albert Einstein at the office, but he needs to be in the conversation. In any startup, a certain acuity is needed to keep the respect of the office and gain the respect of customers and ultimately you as the investor. After all, the CEO drives the ship — make sure you partner someone who knows how to keep afloat.
The trick with a startup is to channel all of the company's limited resources in the best possible direction. With that, adjustments need to be made as markets dictate, so not a single moment is wasted by hesitation. This requires strategic thinking, not formulaic execution. Many executives from larger companies tend to struggle as CEOs because they have not had the opportunity to diverge from a strategy that was passed down to them from above.
The CEO needs to be all-in, no questions asked. He or she needs to be one of those soldiers that doesn't waste a second of their day. The CEO sets the tone at a company, and that should be one of hard work, accountability and reward.
Finding capital to help lift your business off the launching pad is not an easy task, particularly if your product or service falls under a niche market. Maybe investors think your innovation as too outlandish to risk their capital. Fortunately, there's now a well-documented alternative to conventional funding structures: crowdfunding.
But crowdfunding is no longer a radical means to startup capital, it has become a very serviceable and reliable foundation for many companies. Whether your campaign target is $50,000 or $50 Million, you need to know the game your playing. If you are looking to source capital from the public at large, here are three tips to do it right.
Crowdfunding has enabled the launch of everything from virtual reality, video games, hollywood movies and energy efficient vehicles to potato salads, hip-hop clothing, locally made beer and boardgames. There is no limit to what can work with the use crowdfunding, and that's the point. But when you are dipping into the pockets of investors, you need to be able to mollify them along the way. Be mindful that tangible products tend to perform better than services. From an investor's point of view, you invest in a product concept and in return you get the actual product, something that you can see, hold and (in some cases) smell and taste.
"If you build it, they will come." Sure, this ended up working out for Kevin Costner in Field of Dreams, but as we are often reminded, real life isn't like the movies. Market research may sound exhausting both mentally and financially, but in the world of startups, it's imperative. Before you start your campaign, do what you can to get a sense of the demand – then you can use your campaign as means to augment the research you already have.
Proposed new regulations will allow businesses to offer equity in exchange for crowdfunding support. Although the legal requirements mean this option isn't right for every startup, it does offer a more attractive alternative for backers than receiving physical rewards in the mail.


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Autopsy Revelation
Kaveh G. Shojania, MD | March 1, 2004
A 45-year-old male with development delay presented to the emergency department with acute abdominal pain. His mother, who was his main caregiver, accompanied him. The mother was talkative and answered all questions on his behalf, including questions about his symptoms and past medical history.
The mother described the current episode as the sudden onset of severe pain, which initially seemed to be in the epigastric area, but had since moved over to the right upper quadrant and flank. The patient nodded his assent throughout his mother's account. Mother and son stated that the pain was no longer as severe as it had been at its onset, roughly 2 hours earlier. She stressed that he had experienced very similar complaints the previous year, which were diagnosed as due to renal colic.
On physical examination, the patient was moderately obese and appeared in mild discomfort, but no acute distress. His vital signs were normal except for mild tachycardia to 100 beats per minute. Abdominal examination revealed mild tenderness with deep palpation in the epigastrium and right upper quadrant. There was no costovertebral angle tenderness, and rectal examination was unremarkable.
The emergency physician's working diagnosis was renal colic, but he also considered the possibility of gallstones. He planned to obtain a right upper quadrant ultrasound if the pain did not respond to treatment for renal colic or if laboratory tests suggested a hepatobiliary process.
The patient received an intramuscular injection of ketorolac (Toradol), which provided significant relief, as did a second injection 2 hours later. Serum chemistry and blood count results returned within normal limits. Urinalysis was not available, however, as the patient had forgotten the instructions and flushed his urine sample. He was discharged with a prescription for acetaminophen with codeine, instructions to drink at least 8 glasses of water a day, and a strainer for his urine in case he passed a stone, all of which the mother stated she was familiar with based on the previous episode.
The next morning, the patient's mother found him in bed completely unresponsive and with no palpable pulse. Ambulance personnel pronounced him dead at the scene. The medical examiner requested an autopsy, which revealed a perforated gastric ulcer and widespread peritonitis.
The discharge diagnosis of renal colic in this case almost certainly reflected the operation of ascertainment bias (seeing what one expects to find), anchoring (holding on to initial impressions), "premature closure," and confirmation bias.(1-3) These last two terms refer to the tendency to make up one's mind (prematurely) about a diagnosis and then see all findings as consistent with that diagnosis, even when such findings would be atypical (eg, epigastric and right upper quadrant tenderness from kidney stones). The importance of confirmation bias and other cognitive pitfalls that affect diagnostic reasoning have been discussed in this forum (see related commentary) and elsewhere, including our recent book on medical mistakes.(1-5) A different issue raised by this case, and one which has received very little attention in the patient safety literature, concerns the role of the autopsy as a tool for detecting important errors in clinical diagnosis.
Despite its historical role in clarifying, confirming or refuting clinical diagnoses, the autopsy has all but vanished in many hospitals. In 1994, the last year for which United States data exist, the autopsy rate for all non-forensic deaths had dropped to below 6%, from rates of 40%-50% a generation earlier.(6) A more recent survey found that more than half of all hospitals in one state reported performing no autopsies during a one-year period.(7)
The marked decline in autopsy rates undoubtedly reflects various factors, including reimbursement issues for hospitals and pathologists, disappearance of the autopsy from postgraduate educational criteria (except in pathology), the dropping of minimum autopsy rates from regulatory guidelines, as well as general unfamiliarity with autopsy and techniques for requesting it, especially among physicians-in-training.(8) Perhaps the most important reason, however, is that clinicians believe that advances in medical technology have rendered the autopsy unnecessary in all but extraordinary cases.
The assumption that major diagnostic errors have become a rarity is not borne out by existing evidence. Numerous studies document substantial rates of major diagnostic errors detected at autopsy, including errors that likely affected outcome. Studies comparing autopsy findings over 30-40 years at the same institutions have generally found no change in the rates at which autopsy reveals clinically important diagnoses that had escaped antemortem detection.(9-11) Clinicians often attribute these persistently significant and unchanged rates of diagnostic errors to selection bias, arguing that cases sent for autopsy are precisely those in which there is diagnostic uncertainty.
My colleagues and I recently performed a systematic review of the autopsy literature to examine time trends in autopsy-detected diagnostic errors and address the impact of case selection by clinicians.(12) We captured the degree of clinical selection by considering the percentage of decedents undergoing autopsy. In this model, an autopsy rate of 100% would represent no selection, while an autopsy rate approaching zero would reflect extreme clinical selection. The large number of studies available for analysis permitted generation of a model of diagnostic error rates as a function of time, while controlling for clinical selection, case-mix (medicine, surgery, pediatrics, etc.), and country (US vs. Non-US).
Beginning in 1960, major errors—errors in the principal underlying diagnosis or immediate cause of death—decreased at a rate of 28.0% per decade (95% CI: 9.8-42.6%). Despite this relative decrease, the absolute rates of major errors remain substantial. For instance, the estimates generated by this analysis indicated that conducting autopsies in all deaths occurring in a contemporary U.S. hospital would reveal major diagnostic errors in at least 8% of cases, but possibly as many as 22.8%.(12) Moreover, diagnostic errors likely contributed to death in at least 3.8% of all cases, but possibly as many as 7.9% of cases depending on the percentage of decedents undergoing autopsy.
The modest impact of autopsy rates on diagnostic error rates suggests that clinicians are overconfident in their ability to select diagnostically unresolved cases for autopsy. This interpretation is corroborated by prospective studies that found clinicians to have little to no ability to predict cases likely to yield "diagnostic surprises."(13,14) These findings should themselves not come as a surprise. No matter how advanced diagnostic technology may have become, the vast majority of patients do not undergo 'gold standard' evaluations to establish or confirm a working diagnosis.
In the current case, for instance, the patient was discharged from the emergency department with a diagnosis based almost entirely on the history and physical examination. This is not inherently wrong; several studies have shown that some 70%-80% of diagnoses are correctly made on history and physical examination.(15-17) What clinicians often lose sight of, however, is the frequency with which diagnoses rest on little more than the clinical impression and a few basic laboratory tests, rather than a definitive biochemical, radiologic, or histopathologic result.
Of course, sophisticated tests do not guarantee correct diagnoses, even when they have apparently provided a definitive answer. For instance, one of the studies in the autopsy literature specifically looked at cancer misdiagnoses in patients who had undergone biopsy during life.(18) The substantial discordance between antemortem and postmortem diagnoses reflects a variety of factors related to the sensitivity and specificity of diagnostic tests, but probably also reflects the degree to which clinicians seize on a particular diagnosis among the possibilities listed in radiology or pathology reports.
Clinicians are often annoyed at the litany of conditions tacked onto cautiously worded interpretations from radiologists and pathologists: "These findings are consistent with X, but cannot rule out A, B, C, D and E. Clinical correlation is advised." However, these differential diagnoses are given for a reason, and sometimes, when one looks back to understand how a pathologic or radiologic misdiagnosis might have occurred, one sees that the clinicians did not continue to pursue a differential diagnosis that was presented in a study report.(9)
Little is known about the root causes of diagnostic errors, but any given case likely reflects the interplay of human and system-related factors (Table). Conversely, missed diagnoses detected at autopsy do not necessarily represent errors. They may instead reflect acceptable limits of antemortem diagnosis or atypical clinical presentations. Nonetheless, clinicians have an intrinsic interest in important missed diagnoses, even when they reflect atypical presentations or shortcomings of current diagnostic approaches rather than quality problems. Repeated detection of certain missed diagnoses may result in the recognition that some patterns of presentation are more typical than previously appreciated.
This case serves as a reminder of the persistent need to remain vigilant for important misdiagnoses, and of the value of the autopsy in bringing such cases to light. It also illustrates the degree to which misdiagnoses continue to involve common conditions, rather than "fascinomas" and "zebras."
Remain aware of the degree to which first impressions or a particular piece of information may have biased your diagnostic reasoning.
Avoid confirmation bias by having a very low threshold for reopening the differential diagnosis and playing "devil's advocate" with the working diagnosis.
Recognize the degree to which working clinical diagnoses are often based on limited information.
An autopsy is almost always reasonable to consider—do not confuse your (perhaps mistaken) impression of diagnostic certainty and the low value of an autopsy in finding a surprising diagnosis with your (perfectly natural) discomfort with asking the family for permission to obtain an autopsy.
Like discussing advanced directives, asking families about autopsy becomes much easier after you have received some guidance from a more experienced clinician and participated in a few such discussions.
For answers to common questions about autopsies, click here.
Kaveh G. Shojania, MD Department of Medicine University of California, San Francisco
1. Croskerry P. Achieving quality in clinical decision making: cognitive strategies and detection of bias. Acad Emerg Med. 2002;9:1184-1204.[ go to PubMed ]
2. Croskerry P. The importance of cognitive errors in diagnosis and strategies to minimize them. Acad Med. 2003;78:775-80.[ go to PubMed ]
3. Graber M, Gordon R, Franklin N. Reducing diagnostic errors in medicine: what's the goal? Acad Med. 2002;77:981-92.[ go to PubMed ]
4. Kuhn GJ. Diagnostic errors. Acad Emerg Med. 2002;9:740-50.[ go to PubMed ]
5. Wachter RM, Shojania KG. Internal bleeding: the truth behind America's terrifying epidemic of medical mistakes. New York, NY: Rugged Land Publishing; 2004.
6. Burton EC, Nemetz PN. Medical error and outcomes measures: where have all the autopsies gone? MedGenMed. 2000;2:E8.[ go to PubMed ]
7. Burton EC, Nemetz PN, Fisher WPJ, Newman WPI. Institutional characteristics associated with hospital autopsy performance: A survey of Louisiana hospitals [Abstract]. Am J Clin Pathol. 2001;116:590.
8. Rosenbaum GE, Burns J, Johnson J, Mitchell C, Robinson M, Truog RD. Autopsy consent practice at US teaching hospitals: results of a national survey. Arch Intern Med. 2000;160:374-80.[ go to PubMed ]
9. Goldman L, Sayson R, Robbins S, Cohn LH, Bettmann M, Weisberg M. The value of the autopsy in three medical eras. N Engl J Med. 1983;308:1000-5.[ go to PubMed ]
10. Kirch W, Schafii C. Misdiagnosis at a university hospital in 4 medical eras. Medicine (Baltimore). 1996;75:29-40.[ go to PubMed ]
11. Sonderegger-Iseli K, Burger S, Muntwyler J, Salomon F. Diagnostic errors in three medical eras: a necropsy study. Lancet. 2000;355:2027-31.[ go to PubMed ]
12. Shojania KG, Burton EC, McDonald KM, Goldman L. Changes in rates of autopsy-detected diagnostic errors over time: a systematic review. JAMA. 2003;289:2849-56.[ go to PubMed ]
13. Landefeld CS, Chren MM, Myers A, Geller R, Robbins S, Goldman L. Diagnostic yield of the autopsy in a university hospital and a community hospital. N Engl J Med. 1988;318:1249-54.[ go to PubMed ]
14. Cameron HM, McGoogan E. A prospective study of 1152 hospital autopsies: II. Analysis of inaccuracies in clinical diagnoses and their significance. J Pathol. 1981;133:285-300.[ go to PubMed ]
15. Roshan M, Rao AP. A study on relative contributions of the history, physical examination and investigations in making medical diagnosis. J Assoc Physicians India. 2000;48:771-5.[ go to PubMed ]
16. Peterson MC, Holbrook JH, Von Hales D, Smith NL, Staker LV. Contributions of the history, physical examination, and laboratory investigation in making medical diagnoses. West J Med. 1992;156:163-5.[ go to PubMed ]
17. Hampton JR, Harrison MJ, Mitchell JR, Prichard JS, Seymour C. Relative contributions of history-taking, physical examination, and laboratory investigation to diagnosis and management of medical outpatients. Br Med J. 1975;2:486-9.[ go to PubMed ]
18. Burton EC, Troxclair DA, Newman WP, 3rd. Autopsy diagnoses of malignant neoplasms: how often are clinical diagnoses incorrect? JAMA. 1998;280:1245-8.[ go to PubMed ]
Table. Example Root Causes of Diagnostic Errors
System Factors
Faulty data gathering (eg, incomplete history, cursory examination, inadequate laboratory tests)
Inability to perform needed tests in a timely fashion
Failure to follow up on abnormal findings (eg, the murmur that is never looked into or the high calcium that no one follows up on)
Inability to access necessary medical information (eg, outpatient records for hospitalized patients and inpatient records for ambulatory patients)
"Premature closure"—Failure to alter initial diagnosis when faced with inconsistent results
Poor communication between inpatient team members (eg, different clinicians caring for the same patient communicate their thoughts and plans solely through written chart notes)
Failure to ask for assistance from a consultant or supervisor when warranted
Poor communication between inpatient and outpatient physicians
Electronic diagnostic support in emergency physician triage: qualitative study with thematic analysis of interviews.
Mechanical Prosthetic Valve Thrombosis with Thromboembolism.
Cognitive biases encountered by physicians in the emergency room.
Delayed Diagnosis of Mesenteric Ischemia
Miscommunication During the Interhospital Transport of a Critically Ill Child
Missing a Large Vessel Occlusion Stroke in a Patient with a History of Seizures.
Does a suggested diagnosis in a general practitioners' referral question impact diagnostic reasoning: an experimental study.
Discrepancy between emergency department admission diagnosis and hospital discharge diagnosis and its impact on length of stay, up-triage to the intensive care unit, and mortality.
Norepinephrine Dosing Error Associated with Multiple Health System Vulnerabilities
Premature Closure: Was It Just Syncope?
COVID-19: making the right diagnosis.
The NSTEMI Curbside Consultation
Misdiagnosis of a Pelvic Mass versus Pregnancy
Endometriosis: A Common and Commonly Missed and Delayed Diagnosis
Delayed Management of Necrotizing Soft Tissue Infection – Who does the Patient Belong To?
What do emergency department physicians and nurses feel? A qualitative study of emotions, triggers, regulation strategies, and effects on patient care.
Breakdowns in the initial patient-provider encounter are a frequent source of diagnostic error among ischemic stroke cases included in a large medical malpractice claims database.
Spinal Epidural Abscess
In-hospital mortality associated with the misdiagnosis or unidentified site of infection at admission.
'So why didn't you think this baby was ill?' Decision-making in acute paediatrics.
The Wrong Blade: A Lack of Familiarity With Pediatric Emergency Equipment
Shortcuts to Acetaminophen-induced Liver Failure
Missing ECG and Missed Diagnosis Lead to Dangerous Delay
Autopsy interrogation of emergency medicine dispute cases: how often are clinical diagnoses incorrect?
Failed Interpretation of Screening Tool: Delayed Treatment
Hemolysis Holdup


It is almost time for Dragon Boat Festival! Be sure to try our homemade Superior Glutinous Rice Dumpling with Dried Yoshihama Abalone, Conpoy and Kurobuta Pork. Deluxe ingredients including dried Yoshiama Abalone (50 heads), roasted goose, pork, conpoy and salty egg York to suit your appetite!
Rice dumpling will be available for pre-order on 1st May and redemption from 1st -18th June.
Express your gratitude to mother in this meaningful day. Effective from 23rd April until 13th May, GCC members purchasing flowers at Vinoti Garden, G/F D2 Place with presenting GCC member card, can enjoy 15% OFF special discount.


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Mary L. Welty Elementary School » News » What's New » Welty Elementary named 'A+ School of Excellence'
Mary L. Welty Elementary School in Nogales has been named an A+ School of Excellence by the Arizona Educational Foundation, an award that "shines a spotlight on the positive stories and successes occurring in public schools," the foundation announced this week.
Welty was one of 44 schools in the state to earn the recognition this year, and it came after an application process that Principal Aissa Bonillas described as "rigorous and thorough."
"This award would not have been possible without all the help from the students, teachers, staff and parents to make Mary L. Welty the great school it is," Bonillas said in a news release. "I am so honored to be the principal of such a great school."
As part of the application process, Welty had to submit its academic data and answer approximately 50 questions, with the latter assignment involving the contributions of many. Bonillas said the entire school community of administrators, teachers, staff, students and community members broke into small groups to answer the questions, then came together to form a consensus about each answer.
As for its academic data, Welty received grades of B from the Arizona State Board of Education for the 2018-19 and 2017-18 academic years, improving from a C in 2016-17. Those grades are based in large part on students' performance on standardized tests.
"We are very proud that over the last three years the academic achievement of our students has improved to such an extent that we were able to go from a 'C' letter grade to a 'B,' and that we showed growth in almost all grade levels," Bonillas said.
In addition to assessment data, applicant schools are evaluated in the areas of student focus and support, school culture, active teaching and learning, curriculum, leadership, and community and parent involvement, the AEF said.
After earning a slot among the finalists, Welty was slated for a visitation on March 31. However, due to the statewide school closure in response to the coronavirus pandemic, the visitation was held virtually on Sept. 22.
"Our virtual visitation lasted all day. We created an online agenda, and through the virtual platform, the A+ visitors met with parents and the staff and were able to view teachers in action during their Google (online) classroom instruction," Bonillas said.
Fernando Parra, superintendent of the Nogales Unified School District, announced on Oct. 6 that Welty had earned the award.
"What an honor for NUSD and our school community. Principal Bonillas, her staff, students and parents have created an outstanding school culture of excellence," Parra said.
Welty is the second NUSD school to win the award, following Francisco Vasquez de Coronado Elementary School in 2019.
Schools that achieve the distinction receive $500 and a banner designating them as an A+ School of Excellence winner. The award is valid for four years.


Introducing the 2017 Dodge Grand Caravan. This 7 passenger van still has fewer than 30,000 miles! Under the hood you'll find a 6 cylinder engine with more than 270 horsepower, providing a smooth and predictable driving experience. Dodge prioritized comfort and style by including: delay-off headlights, a tachometer, front bucket seats, automatic temperature control, a power liftgate, remote keyless entry, and a split folding rear seat. Storage solutions are integrated throughout the interior, demonstrating thoughtful attention to detail. Premium sound drives 6 speakers, providing you and your passengers a sensational audio experience. Dodge also prioritized safety and security with features such as: dual front impact airbags with occupant sensing airbag, head curtain airbags, traction control, brake assist, anti-whiplash front head restraints, a panic alarm, and 4 wheel disc brakes with ABS. With electronic stability control supplementing mechanical systems, you'll maintain precise command of the roadway. We pride ourselves in consistently exceeding our customer's expectations. Please don't hesitate to give us a call.


Let your guests lounge and relax while sipping on a tasty cocktail, enjoying delicious hors d'oeuvres, and viewing the local artwork throughout the gallery. We offer a beautiful modern lounge furniture package that you can dress up as your own. You also have the option to choose any caterer from our list, and bring in your own alcohol, so you can spend money where it is most important to you and your fiancé.
Cocktail hour is a great time to go out and get the first gorgeous photos of you as a married couple. Our space is very unique and offers many different options for photo backdrops such as under our Love sign, in front of our ivy wall, next to the quotes on our building, and with the mountain views behind you. We are also in downtown Boulder, so you can walk through the alleyways for a funky urban setting, or easily go to Chautaqua Park for photos directly underneath the mountains.
Feel free to use our in-house sound system for background music during cocktail hour, or you can bring in a musician to set a romantic and relaxing ambiance. You also have access to our wireless microphone for any welcome speeches, toasts, or announcements.


Northumberland County is situated on the north shore of Lake Ontario, in central Ontario. It is located east of the Regional Municipality of Durham, west of Hastings County, southeast of Kawartha Lakes, and south of Peterborough County. The population of Northumberland (combining the County and Alderville First Nation) is 85,598.
Northumberland is part of the Kawartha Pine Ridge District School Board and Peterborough Victoria Northumberland and Clarington Catholic (PVNCC) District School Board. The Northumberland area also has one OPP Detachment and two police services. Northumberland is serviced by Northumberland Hills Hospital in Cobourg and Campbellford Memorial Hospital in Campbellford.
Northumberland County consists of seven municipalities with Alderville First Nation within the Northumberland census division but is independent of county administration.