"Kudos to Mansbridge for never complaining that I referred to him as 'Pastor Mansbridge' for years. It can't be easy to be constantly teased. We all extrapolate from the time we spend watching someone in Mansbridge's role on TV and what we extrapolate from Mansbridge and his career comes down to individual response, not necessarily what the news anchor or broadcaster wants."
Wednesday morning, a man called the Toronto Star saying he was "at a breaking point." It was clear this was unlike any other call into the newsroom.
"It began with what seemed like any other tip called in to the Toronto Star's 24-hour news desk.
"But the man on the line — his voice steady, at times upset but never once raised — would soon reveal he had made a desperate move.
"He was 'at a breaking point.' He needed to be listened to. This is what it would take, he said.
"Over the phone, a woman's desperate screams could be heard — 'I have family!' she cried.
"It was clear this was unlike any other call into the newsroom."
The Toronto Star is laying off 30 employees as it shutters its Star Touch tablet app — a multi-million dollar bet on bringing in younger readership that failed to meet management expectations, CP reports.
Twenty-nine full-time employees and one part-timer have been notified that they will lose their jobs, said Toronto Star spokesman Bob Hepburn. Some of those employees will continue to work for a while longer and some may be able to stay with the company if they choose to act on a bumping provision contained in their contracts, he said.
The tablet-only app will be replaced by one for smartphones as well as tablets, Hepburn said. The so-called universal app will be available to readers before the end of July, while the Star Touch's latest edition will run on July 31.
Torstar launched the app in September 2015 and invested more than $20 million in the venture.
Three CNN journalists, including the executive editor in charge of a new investigative unit, have resigned after the publication of a Russia-related article that was retracted, CNN reported on its web page.
Thomas Frank, who wrote the story in question; Eric Lichtblau, an editor in the unit; and Lex Haris, who oversaw the unit, have all left CNN. "In the aftermath of the retraction of a story published on CNN.com, CNN has accepted the resignations of the employees involved in the story's publication," a spokesman said Monday evening.
An internal investigation by CNN management found that some standard editorial processes were not followed when the article was published, people briefed on the results of the investigation said. The story, which reported that Congress was investigating a "Russian investment fund with ties to Trump officials," cited a single anonymous source. These types of stories are typically reviewed by several departments within CNN -- including fact-checkers, journalism standards experts and lawyers -- before publication.
"When al-Jazeera was launched, the then emir Hamad bin Khalifa al-Thani said journalists would "report the news as they see it". Al-Jazeera still claims to have been the "first independent news channel in the Arab world".
"The launch of an English-language channel in 2006 was part of a dramatic global expansion that has led to the establishment of more than 70 bureaux around the world.
"Al-Jazeera launched a US cable news channel in October 2013, but this proved to be the peak of its growth, for now at least.
"Al-Jazeera America was closed last year amid dwindling viewing figures and a collection of lawsuits."
'Postmedia Network Inc., a wholly owned subsidiary of Postmedia Network Canada Corp. ("Postmedia" or "the Company") today announced a definitive agreement to sell its media monitoring division Infomart to Meltwater News Canada Inc., a global leader in media intelligence, for gross proceeds of $38.25 million, subject to adjustments. An amount equal to 15% of the purchase price will be paid into escrow to satisfy claims arising under the purchase agreement. The net proceeds from the sale will be used for debt repayment."
"Al Jazeera was accused, respectively, of being anti-Western, pro-Israel, Islamist, pro-Iraq, anti-religious, and funded by the CIA. It was also enormously popular. By 1999, when the channel began 24-hour broadcasting, it had twelve international bureaus and employed over 500 people.
"After 9/11, the network gained prestige and made an enemy out of the Bush administration by regularly broadcasting interviews with Bin Laden and footage of American airstrikes in Afghanistan, where it was initially one of the only international channels with a camera crew on the ground."
The National Post is eliminating its Monday print edition as of July.
Two of Canada's top journalists have testified they were shaken to discover what they allege are half-truths and lies used by some police forces in Quebec to obtain search warrants from credulous courts to track journalist telephones.
Marie-Maude Denis, an investigative reporter with Radio-Canada who was pivotal in uncovering the construction and political financing scandal in Quebec that triggered a public inquiry and dozens of arrests, and Patrick Lagacé, a columnist for La Presse, an occasional contributor to The Globe and Mail and one of Quebec's most prominent TV personalities, testified Thursday at the province's public inquiry into police surveillance of journalists.
Three anchors will replace Peter Mansbridge at the new version of CBC's flagship national news program, "The National," the Huffington post reports.
The incoming hosts will also report in the field, said Jennifer McGuire, general manager and editor-in-chief of CBC News. However, the people who will fill the high-profile positions are still being decided.
"As yet, no decisions have been made with respect to who will replace Peter and October 30th is the launch date, "said CBC spokesman Chuck Thompson in an email to HuffPost Canada on Thursday.
"Mr. Knight began as a producer at CBC before spending 20 years at the Financial Post, including time as publisher and CEO. He was part of a management-led leveraged buyout of Toronto Sun Publishing Corp. from Rogers Communications Inc. in 1996, after which he served as publisher of the Toronto Sun. In 2000 he moved to New York and in 2003 became CEO of Spanish-language newspaper company ImpreMedia. He returned to Canada, to his post at St. Joseph, in 2006."
The London Free Press has won the 2016 Michener Award for its series Indiscernible, an investigation into the death of a local man that led to changes in Ontario's criminal, corrections and mental health systems.
"The judges concurred that this two-year investigation exemplifies the best in public service journalism and the critical value of local media," said Russell Mills, president of the Michener Awards Foundation.
In an incredibly corny post on its web page, CBC today announced the launch of a radio station in London, Ont.
"Take a look as the host of London Morning, Rebecca Zandbergen, makes history in the Forest City with the launch of the CBC's newest station. . . .
"CBC London will produce all-day local digital and radio programming with a focus on southwestern Ontario in the afternoon."
"The lawyer who bested the combined might of the Ontario AG's office and the RCMP in the criminal trial of Senator Mike Duffy says he was shocked by the uniformed media "maelstrom" that formed against his client — a bias which he says continues to this day.
"Donald Bayne says that the entire experience has convinced him that something has to be done about elevating news coverage of the courts from vaudevillian info-tainment to accurate reporting — and that something might even be the creation of a 'press judge', as the Canadian Bar Association suggested in a 2016 article.
"The stakes couldn't be higher: the public's right to get the facts rather than emotional rants from the media — and an accused's right to be presumed innocent until proven guilty.
"When asked by iPolitics if he had been ready for the media gauntlet both he and his client had to run for nearly three years in a case that pitted his client against public opinion and the PMO, Bayne didn't beat around the bush.
The 133-year-old French-language newspaper, owned by Power Corp., said Thursday its last Saturday print edition will be published Dec. 30.
La Presse had already ceased publishing a daily print product on Jan. 1, 2016, and the latest move is a continuation of that transition.


Director On Call — Director On Call Wins CAM-X Award of Excellence for 16th Year!
Director On Call Wins CAM-X Award of Excellence for 16th Year!
At the CAM-X 51st Annual Convention and Trade Show held at the Hilton Doubletree in Charleston, South Carolina, Director On Call was honoured with the exclusive 2015 CAM-X Award of Excellence for the 16th consecutive year!
The award is presented by the Canadian Call Management Association. The calls are judged using various criteria including response time, accuracy of the call, knowledge of the account, etc.
Our President Brad Frenchhas this to say; "It is incredible that we have been able to deliver incredible service for 16 consecutive years. Our team works extremely hard to provide top in class service and this award displays that we have achieved this yet again."
"The CAM-X Award of Excellence is a proven benchmarking program that enhances customer service for the Telephone Answering Service Industry throughout North America and the world." says CAM-X President Debbie Iacovone. "Technology advancements have made it possible to meet a variety of client needs yet it is the agents who take the calls that determine the overall customer satisfaction levels. The CAM-X Award of Excellence ensures agents not only meet the consistent, professional service levels clients demand, but exceed them. Since the inception of this Awards Program member participants have seen these service levels soar. I congratulate Director On Call for their achievements and commitment to excellence."


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Home » Celebrities » Amy Winehouse hologram tour set for 2019
Amy Winehouse hologram tour set for 2019
An Amy Winehouse hologram will tour the world next fall as part of a new partnership between the singer's estate and BASE Hologram.
An exact start date for the trek has yet to be announced, though it's expected to kick off late 2019.
Per a statement, the show will feature "digitally remastered arrangements of [Winehouse's] classics" while the hologram "will be backed by a live band, singers and theatrical stagecraft."
"This is a dream for us," said Winehouse's father, Mitch. "To see her perform again is something special that really can't be put into words. Our daughter's music touched the lives of millions of people and it means everything that her legacy will continue in this innovative and groundbreaking way."
The hologram tour will also raise money for the Amy Winehouse Foundation. The organization works to combat and prevent drug and alcohol abuse among young people, while also providing other services to disadvantaged youth.
The Winehouse trek will mark BASE Hologram's third major musical hologram tour.
This fall, the company launched its first two productions, one featuring Roy Orbison and the other beloved opera singer Maria Callas. Next year, the company will also debut a location-based project, "Discoveries: Jack Horner's World of Dinosaurs," which will feature renowned paleontologists guiding viewers through the Jurassic era.
"Amy was an extraordinary individual who had an unbelievable passion for both her music and her fans," said BASE CEO of productions, Marty Tudor. "This tour will tap into that devotion and remind people of her amazing voice and all of her contributions to the world of music. In addition, we are proud to be a part of contributing to the Amy Winehouse Foundation and Amy's legacy of commitment to others in need."
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redpajama_set_name: RedPajamaCommonCrawl


You may be delighted to know that our unique home is fully licensed. We have an extensive wine list from beautiful house to fine wines. Meet in the drawing room for an aperitif, relax in front of the fire with a cognac, or tipple of your choice.
Please ask to see our wine lists (subject to availability) , we're happy to provide advice on matching wine to dinner.


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Transportation > Communications > News and Announcements > Wheeling Suspension Bridge closed to vehicular traffic after continued public disregard of safety signs
Wheeling Suspension Bridge closed to vehicular traffic after continued public disregard of safety signs
CHARLESTON, WV – Due to the traveling public's continued disregard of weight limit and safety signs on the Wheeling Suspension Bridge, officials with the West Virginia Department of Transportation have opted to close the bridge to vehicular traffic for the foreseeable future.
The closure is effective immediately.
"This is not something that we wanted to do," Secretary of Transportation Byrd White said. "The whole reason we have the safety signs is because we wanted everyday motorists to be able to continue using this iconic and important bridge, while also stopping the heavier traffic that has caused structural damage in the past.
"Unfortunately, the operators of those heavier vehicles continue to ignore our restrictions," Secretary White said. "While the bridge is absolutely in safe condition now, we need to make sure that we're doing everything we can to prevent future damage. Therefore, our only choice is to close the bridge to all motorists for the time being."
The bridge will remain open to pedestrians and bicyclists.
Earlier this year, the bridge had to be closed for six weeks after a tour bus – which far exceeded the posted two-ton weight limit – attempted to cross the bridge, only to get stuck under a barrier.
Upon the bridge being deemed safe and reopening to traffic in August, officials from the Division of Highways installed a height barrier with hard restraints to attempt to eliminate such overweight crossings.
However, in the time since, operators of additional vehicles over the weight limit have continued to ignore the restrictions, and have repeatedly driven on the bridge.
"We want to do everything possible to protect this historic structure," Secretary White said. "In this case, that means stopping vehicular traffic altogether."
The Wheeling Suspension Bridge was constructed in 1847 and was part of the National Road – the first major improved highway in the United States built by the federal government, running from Maryland to Illinois. It was the main passageway to the west and was the largest suspension bridge in the world from 1849 to 1851.
The bridge is now a U.S. National Historic Landmark.
The Division of Highways is currently working on a long-term rehabilitation plan to sustain the bridge far into the future.
Brent.H.Walker@wv.gov


De-registers the function function so it is no longer executed when a tick is called.
So if you want to unregister it must be done outside of the handler.
Note that unregister_tick_function() can also accept a callback in the form of an array (either static, like array($className, $methodName) or instance, like array(&$this, $methodName)).
It cannot accept an anonymous function, however.


Alberta Solicitor General Fred Lindsay wants "more policemen on our streets" (Calgary Herald, October 21, 2008). This is a standard conservative incantation and a general government hang-up, the "Hare Krishna" of the statocrats. But the question must be raised, why in heavens do we need more policemen?
Our society is already full of them. In 2007, there were 64,000 policemen in Canada, 25% more than two decades ago. Over the same period, total expenditures on policing have jumped from $4 billion to $10 billion.
"No absolute monarch ever had at his disposal a police force comparable to those of modern democracies", wrote Bertrand de Jouvenel in On Power (1945). In a city of 1.6 million inhabitants, the Montréal Police Department employs more than 7,000 persons, not counting the provincial and federal cops roaming around. This is about the number of policemen and soldiers in late-17th-century Paris, where modern, centralized policing was created. It must be admitted that the French capital was then about half the size of today's Montréal (see Marc Chassaigne's delicious 1906 book La Lieutenance générale de police de Paris), yet today's police are far better equipped, better informed, and more powerful than anything Louis XIV could dream of.
So why do we need more policemen? To enforce laws, of course. But this raises the question, "which laws?" And this is the main issue in the real world. Most of the laws that "policemen on our streets" enforce are, like in 17th-century Paris, designed more to protect the state apparatus than the subjects' liberties. Canada's Criminal Code contains 600 pages of crimes, of which a big chunk are crimes against the state and state morality. Twenty-five pages are concerned with the criminalization of guns. The definition of "terrorism" seems carefully crafted to protect the state against domestic insurrection.
Only one-sixth of the Criminal Code — one-third if we exclude all the procedural stuff — is concerned with the protection of person and property, but even these portions of the Code are encumbered by speech crimes (like "hate propaganda" and defamation), by scams like the prohibition on driving after two glasses of wine, by such fabricated crimes as polygamy, blasphemous libel, criminal interest rates, insider trading, "discrimination against trade unionists", and by such terrible crimes as "[operating] a vessel while towing a person on any water skis, surf-board, water sled or other object during the period from one hour after sunset to sunrise".
Most criminal law, when it is not designed to protect the state, aims to impose state-defined morality on those who partake in victimless "crimes" — with disastrous consequences. The war on drugs has led to gang wars, the killing of innocents, scores of lives broken by criminal records, and a wholesale onslaught on our liberties. Close to 25% of all criminal charges that come before Canadian courts involve illicit drugs. A large part of the prison population is there for drug-related crimes. Even cigarette smugglers now get jail sentences! Money laundering, a crime recently invented to fight drugs, covers more than 15 pages in the Criminal Code.
And this does not count all the other liberticidal non-criminal legislations, whether federal, provincial, or municipal, that impose prohibitions, regulations, licences and permits, and carry fines or jail sentences. In many provinces, civil forfeiture laws have been added to the feds' criminal forfeiture, empowering provincial governments to administratively seize property allegedly related to law breaking.
We are not very far from England where cops are more interested in arresting people who exercise their right to self-defence and in prosecuting "crimes" against political correctness than in going after old-fashioned violent crimes.
Look, young fellow, this is the world as it is. Policemen have reverted to their first function: praetorians of the state. You want an emblematic example? The bureau of the Québec provincial police that enforces federal gun controls reports to the "Direction de la protection de l'État", that is, literally, the Directorate for the Protection of the State, which might be translated in better English as the State Security Directorate, a name even more authoritarian sounding that the old "State Security Committee" or KGB.
It is some claim that we need more of these praetorians on our streets!


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It's the taking part...
According to the organizers, encouraging participation in sport is one of the main benefits of the London 2012 Olympics. Mark Perryman examines the evidence.
The Olympic motto " The most important thing is not winning but taking part" represents some of the finest ideals not only of Olympism but of any sporting event aspiring to be democratic, participative and accessible. After this weekend's Jubilee hoopla fades away, the coming summer of sport - Euro 2012, a serious British challenger to win the Tour de France, Wimbledon fortnight, overseas rugby tours to the southern hemisphere, a domestic test match series and the first, and last, home Olympics for most of our lifetimes - will no doubt test such sentiments to the full. A nation that invented many of the world's team sports has, perhaps forgivably, some difficulty in coping with repeated defeats by the nations to which it exported them. Add in a lengthy martial and imperial tradition, and CLR James' famous maxim 'What do they know of cricket who only cricket know' can be seen as essential to understanding why the British are not the world's best losers.
Now well into its second week the Olympic Torch Relay would seem, at first sight, to represent all that is good about sport. Crisscrossing the country, coming soon to a city, town, or village near you, it appears to epitomize what 'taking part' should be all about. But looked at more closely, it reveals the flimsy populism and chronic lack of ambition that London 2012 has come to symbolise. The Relay has undoubtedly proved popular; any event with this scale of media coverage was likely to attract large, inquisitive crowds. And the passion of those turning up is evidently genuine. But how is that energy connected to participation in the Games beyond waving a flag, cheering from the kerbside, and providing a backdrop to the celebrity torchbearers and sponsors' branding? What opportunities does the Relay really present for taking part?
A Torch Relay for all would have made popular participation its organising principle. For each 10k leg, the roads and pathways could have been closed for the torchbearer to be followed by fun runners and active walkers, in the style of the London Marathon or Great North Run. This could have been the biggest venture ever in participative sport. But such opportunities have been spurned because they might detract from the all-important messages of sponsors. Villages, towns, localities within a city, each could have been given their stretch of the route for thousands to run or walk along. Other legs could have been given over to cyclists, canoeists, ramblers and fell-runners, sailors and any other mode of human powered, or human steered transport. And why, on most nights, does the Relay stop with the Olympic flame transferred from the evening's finishing point to tomorrow's starting line by car? What an experience it would be for club runners and cyclists to venture through the night, taking the torch to every part of the land. In this way many more than the limited numbers now talking part could have been involved
But even with these changes the Relay would still leave most parts of the country with only a fleeting glimpse of the Torch as their solitary direct experience of the Olympics. This reality has been dutifully accepted as fact by almost every media cheerleader for London 2012. It is as if the removal of all critical faculties is a condition of highly-valued journalistic accreditation. An Olympic programme which included a multi-stage cycling Tour of Britain could have covered all parts of the country, and perhaps neighbouring nations too, as a thrilling contest throughout the duration of the Games. And why not hold a Round Britain yacht race visiting the ports of coastal Britain? Add a half marathon and a 10k road race to the running events, a canoe marathon and a multi-stage mountain bike race,and you begin to build a genuinely participatory Olympics, free-to-watch, decentralized, and with routes that are capable of accommodating enormous crowds from the sidelines. In this way we can begin to re-imagine what the Olympics might look like.
Such changes, which would accommodate the widespread appetite of millions who want to take part, will not be easily achieved inside the existing framework of the Games' organization. Sport, as CLR James also insists, is socially constructed. The late twentieth century popularity of sport as a TV spectacle , fashion statement ,and branding target for sponsor has been accompanied by a headlong decline in participation in organised sporting activity. Those sports that have enjoyed growth have largely been individual ones such as [GIVE EXAMPLES HERE] , a source of recreation rather than competition. The irony of the Olympics is that its current ethos, with an emphasis on the enormous gap between professional top-flight athletes and everyone else, sharply limits the possibility of popular participation. The challenge is to come up with a Games that breaks with this tradition to create a People's Games in which all can take part.
Mark Perryman is the author of the forthcoming book Why The Olympics Aren't Good For Us, And How They Can Be, available at a 15% pre-publication discount from www.orbooks.com/catalog/olympics/
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Is pygame a good way to teach children programming?
Here is an interesting post.
Would children be interested in programming old computers the old way, the way many programmers became enthralled with programming?


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Lyme and biliary disease
Most readers have some familiarity with the liver and gallbladder. The biliary (bile duct) system includes the gallbladder and a collection of ducts coming from the liver which join to enter the first part of the small intestines, the duodenum, the first part of the small intestines (bowel) just below the stomach.
The liver is best known as our body's detoxification organ (along with kidneys). The liver "metabolizes," alters and excretes medicines and other substances.
The liver makes bile, a yellow viscous fluid stored in the gallbladder, located directed under the liver. The gallbladder contracts with meals. Bile made of bile acids, from cholesterol, aid in the digestion of fat (an emulsifier) but has many other functions.
The liver detoxifies medications and toxins through a system of enzymes with names like cytokine P450. Toxins and medications may end up in bile.
Adsorption of medications may be dependent on something called the enterohepatic recirculation of bile.
Most bile is recycled from the gut which is considered 95% efficient. A particular bile acid molecule may be used 20 times before it is replaced. This is not necessarily a bad thing. The process of repeated cycling may enhance the function of therapeutic drugs and delay their excretion. For liver toxins this works the other way. Proper functioning of the enterohepatic system depends in part on a healthy gut flora and specific bacterial enzymes. Higher doses of antibiotics may be required because disruption of normal flora and necessary enzymes caused by the antibiotic(s).
The use of bile acid sequestrants to remove unknown toxins like cholestyramine is not supported by scientific evidence.
Some antibiotics promote the production of biliary cholesterol sludge and gall stones, primarily Rocephin, the popular intravenous drug used to treat Lyme disease. Cholecystitis (gall bladder attacks) with or without the presence of gall stones is a common occurrence.
Lyme anecdotally can attack the biliary system. Cases of positive Lyme PCR/DNA from gallbladder tissues are known to me but there are no published reports to date.
Published reports have established Lyme liver disease in the form of granulomatous hepatitis.
Tests like sonogram, HIDA/CCK scan and others may be used diagnostically for problems with gallbladder and bile ducts. Negative test results do not rule out gallbladder/biliary disease.
I am treating a patient with primary biliary cholangitis (PBC). Generally, the disorder is considered autoimmune, "idiopathic," which of course means the patient is pathological and the doctor is an idiot. Some European literature (this patient is European) connects Lyme with this enigmatic illness. The patient has a clear history of Lyme. No such connection is made in the U.S. PBC is now a treatable disease.
Bile via an array of ducts ultimately empties into the common bile duct. Bile the empties into the duodenum into a structure called the Ampulla of Vater. The flow of bile is regulated by a muscle called the sphincter of Oddi.
After cholecystectomy, (surgical removal of the gallbladder), prior gallbladder pain may seem to recur. The bile ducts may become dilated. When a medical workup excludes a left-over stone stuck in bile duct, liver disease, pancreatic disease and other rare diseases, the diagnosis may be post-cholecystectomy syndrome or sphincter of Oddi dysfunction.
These syndromes are more common in Lyme patients, many of whom suffer with gallbladder disease and biliary tract disease and have had their gallbladders removed.
The diagnosis is commonly missed or not taken seriously. The disorder can be disabling. Effective medical therapy, in my recent experience, is available but overlooked.
PANDAS: diagnosed 15 years after the fact
A young adult is struggling with PANDAS/PANS and much more. He is 33 years old, I diagnosed him at age 29. I treated him briefly. We arranged a single dose of IVIG. The plan was long term therapy. He was directed to another physician who treated him with a single dose of IV rituximab. He got better – for a while but quickly regressed.
He had a normal childhood – until he didn't, excelling academically and in sports. But that changed overnight. One day normal the next the beginning of a nightmare that has never ended. Mom and dad wanted to know what happened to their son. He had become a different person, for no good reason, out of the blue. He became withdrawn, irritable and rageful. He developed tics, anxiety and OCD. Mom took him to his pediatrician who referred him to a psychiatrist.
He was dosed with psychotropic meds which never made a difference. He refused to go to school.
Finding no alternative, his parents sent him off to boarding school for 2 years. He returned sullen, paranoid and angry. He dropped out of school and worked odd jobs, never for more a few months. He wandered around, from on place to the next, from one relationship to the next.
There were numerous suicide attempts and hospitalizations. He was given every psychiatric diagnosis in the book, schizoaffective to borderline personality to bipolar. He was prescribed every psychotropic: atypical antipsychotics, SSRIs, SNRIs, mood stabilizers, anticonvulsants and lithium. The diagnoses were wrong, and the medications never worked.
He lives on the other side of the country and I have not seen him in years. I care for a family member who referred him to me because he suffers with Lyme disease and thought the patient might have the same.
Our patient is a little better than he was the day I met him, but he is not a functional human being.
He is uncontrollably enraged constantly mourning the life he has lost. He is so angry at his parents. Unfairly he blames them for the delayed diagnosis of PANDAS (15 years), and there is so much other water under the bridge.
He in fact has Strep related PANDAS and also tickborne disease picked up later which stoked the fire.
The medical literature offers nothing in this case and other like it stating PANDAS is a pediatric illness. An NIH paper admits some young adults may be afflicted but it stops there.
Unfortunately, I suspect there are a lot of patients who have a similar story. PANS was not diagnosed in childhood. In adulthood they are diagnosed. What is there to do about it. And I do have other similar patients in my practice.
Do doctors imagine that undiagnosed pediatric PANDAS cures itself in adulthood? The problem is doctors who write papers are academics and don't see a lot of patients. They only see cohorts of carefully culled patients who meet study criteria. And they usually don't see those patients for long term follow up.
Patients are frequently diagnosed with Strep, Lyme, Bartonella and others.
Treatment, the right treatment can be prohibitively expensive. Tonsillectomy is recommended and may help. Antibiotics are part of the treatment. There may be psychiatric Herxheimer reactions. Steroids are "the poor man's IVIG." A therapeutic response to steroids is predictive of a positive response to IVIG. IVIG is dosed high, 1.5-2 gm/kg every 3 weeks may be effective. Rituximab is a third line treatment. Some patients are managed with a combination of IVIG, Rituximab, steroids and antibiotics. Whatever works.
These patients need a lot of supportive services and therapies.
All of this new, largely opinion driven, because there is little research or science. The waters are uncharted because PANDAS wasn't recognized until the late 1990s and tickborne PANS much later. There may be countless young adults suffering in much the same way.
Naturally I think my approach is the most logical and effective given what we currently know.
Treatment: tonsillectomy, antibiotics, steroids, IVIG, rituximab. Rituximab is not a substitute for IVIG, it is third tier therapy.
Intensive therapy and psychotropic meds are going to be part of the picture. Psych drugs are not bad. It fact, they are incredibly helpful. It must be understood these meds are adjunctive, supportive and do not target the underlying cause of the illness.
Disulfiram resistant strains of Lyme!
No. I don't know if there are disulfiram resistant strains of Lyme. However, the emergence of such strains seems inevitable but may be preventable.
How does disulfiram kill bacteria? Biochemistry. Disulfides or thiols bind to critical metabolites in the bacteria. Medical literature claims it has a narrow spectrum of action killing specific gram-positive organisms, like Staph aureus and several others. The construction of the cell wall of susceptible bacteria determines the entre of the drug. Spirochetes like Borrelia burgdorferi, are neither gram positive nor negative. The out surface of the spirochete is comprised of double membrane, one that is lipophilic (loves fat). The disulfiram molecule is also lipophilic (loves fat). This shared biochemistry dooms the Lyme spirochetes. The disulfiram molecule carrying its poisonous chemicals is a trojan horse and quickly puts the spirochetes out of commission.
A narrow spectrum may be a good thing. This is the ideal scenario. The drug kills the target and only a few bystanders (collateral damage). Most antibiotics essentially nuke, or carpet bomb our bodies, carrying around their 2-8 pounds of normal flora – bacteria, indiscriminately killing huge numbers of good guys.
Disulfiram represents an entirely new class of antibiotic with a novel way of killing bacteria.
Traditional antibiotics work by inhibiting cell wall synthesis, inhibiting protein synthesis by disrupting ribosomes, interfering with DNA or RNA function – and that's about it.
We don't know if antibiotic resistance will emerge against disulfiram. The best predictor of what might happen is history.
There currently exist bacteria resistant to antibiotics from each of the known classes.
It may be wise to listen to Alexander Fleming, the Nobel laureate who discovered Penicillin. Over the course of his career he watched susceptible strains of Staphylococcus become resistant to the the wonder drug, penicillin, in a few short years.
He cautioned that one must make sure the antibiotic is necessary, then make sure the dose is high enough and the drug is given long enough to prevent the emergence of resistant strains of bacteria.
Popular pulsing and prescription of low, subtherapeutic doses of antibiotics/disulfiram are practices which needed to be avoided lest we kill the goose who lays the golden eggs
The emergence of resistance is nearly universal. It has happened with every bad infectious disease you can think of, ranging from malaria and tuberculosis to HIV. It is the rule, not the exception.
The Lyme buggers are very, very smart. Expect no less.
ID doctors and the IDSA frequently talk about stewardship of antibiotics. I think they are frequently wrong about the details, but the concept is sound.
The thousands of patients suddenly taking disulfiram are a Facebook ragtag army with no sense of the history of antibiotics and germs and the decades long battles, lost and won.
My suggestion is simple but probably hard to implement.
Hit Lyme hard and long (disulfiram, and as I think about, a cocktail of other antibiotics makes a lot of sense). Treat for months after the disappearance of symptoms.
Using disulfiram as monotherapy, the only drug, may accelerate the evolution of disulfiram resistant Lyme strains.
In the words of the immortal Bob Marley "you have to kill it before it grows."
Disulfiram, disulfiram and Monurol?
Perhaps, when the history of Lyme disease is told at some future date, it will be divided into the pre-and post-worlds of disulfiram. Maybe since Antabuse is not classified as an antibiotic, the IDSA will back off, who knows.
The drug seems to be amazingly effective for so many patients. Still, it's not for everyone. Some patients tolerate relatively high doses of the drug out of the gate; for the most part, is better start low and gradually increase the dose as many patients do not tolerate high doses. The effective dose is unknown. 250 mg may be effective for many patients (not 500 mg).
Patients have had a hard time finding the drug, scouring pharmacies across the continent. A patient I saw today did incredibly well after 6 weeks of therapy. Then, she could not find any more drug and symptoms returned with a vengeance. She is now well stocked from an overseas pharmacy. With nearly 30 years of disease, the majority of her life, she suffers with POTS, EDS and MCAS – and chronic pain. Antabuse is not going to fix everything. I continue to enjoy excellent success managing pain without opioids.
Antabuse for most patients may not be a quick fix. But it's effectiveness is undeniable and it is quickly changing the game.
Elevated liver function tests are common. Frequently the drug can be stopped for several days until labs normalize and tolerated at a lower dose without budging liver numbers. Liver function tests in excess of 3 times the upper limit of normal (120ish) should be of immediate concern.
Another novel therapy been very effective for 1 of my patients. Fosfomycin, Monurol is a 3 g powder is typically used for urinary tract infections. It also works very well against Lyme persister. With a typical UTI the dose is a single 3 gm packet. The drug has a prolonged duration of effects, about 48 hours, despite a short half-life: it continues to work because of its PAE (post antibiotic effect). A current patient is responding beautifully to twice weekly dosing along with doxycycline and Zithromax – Zithromax combined with Mepron for Babesiosis.
There are more great and effective options than ever before, including IV daptomycin.
I am accepting new patients with Lyme (and coinfections) and a host of other conditions: PANS, POTS, CVID, CIDP, EDS, MCAS, CFS, FMS, neuropathic and central pain syndromes, headaches and chronic, mysterious difficult to diagnose ailments.
I offer blood Giemsa staining screening for active Babesia infection: Lab CLIA approved and certified by College of American Pathologists.
Blogging about Lyme and related topics since 2008.
Disulfirm/Antabuse
Its true: Antabuse/disulfiram is the most exciting new therapy for Lyme since daptomycin.
We are getting a lot more experience with disulfiram/Antabuse. In some cases, it seems to be very effective. I don't think it is clear which microbes it is active against. It is an old drug repurposed as an antibiotic. Its antimicrobial spectrum may remain unknown for the foreseeable future (there is no money researching it). One thing worse than dreaded MRSA is VRSA – vancomycin resistant Staph aureus. In vitro it was shown that the addition of disulfiram to vancomycin conferred the ability to kill this dreaded superbug. This should be catching some eyes, even outside the Lyme world.
Disulfiram clearly has potent antibiotic effects. It also has side effects. Twenty five percent of users have some rise in liver function tests –markers of liver inflammation. The rise is usually modest, and therapy can continue if AST/ALT numbers don't exceed 2-3 twice the normal limit, with close monitoring. Three times makes me nervous. My comfort zone limits closer to 2. Waiting for numbers to normalize and restarting with a lower dose may work. Severe liver disease may occur 1-2% of the time, not a trivial number.
ONLY YOUR DOCTOR CAN MAKE CLINICAL DECISIONS REGARDING ANTABUSE AND LIVER TEST. THIS IS WRITTEN FOR GENERAL INFORMATIONAL PURPOSES ONLY; FULMINANT LIVER DISEASE CAN BE FATAL.
You should never treat yourself. The man who has himself as his doctor has a fool for a patient.
Side effects may include, dizziness, brain fog, fatigue, GI intolerance and others – in my patients. Many patients have had to discontinue because of side effects. Monotherapy may be fine. It runs counter to my experience, so I tend to prescribe it with doxycycline.
A word for the wise. We don't really know how safe the drug is. Sometimes problems only become known when an occasional drug becomes one in common use. We have seen it over and over, for example, fenfluramine off fen-fen fame caused unexpected heart and lung disease and Vioxx the great new anti-inflammatory caused heart disease. Drug companies who have studied drugs extensively and had FDA approval call this "post-marketing" side effects.
Yes, Antabuse is an old drug used by hundreds of recovering alcoholics. When this old drug, largely disregarded from decades, it is suddenly used by thousands of lyme sufferers it many ways acquires characteristics of a new drug. In this case one that has not been tested. Quality control of generics is increasingly becoming an issue, e.g. Zantac.
I am prescribing the drug, just not throwing caution to the wind.
There is the issue of dose. For alcoholics the loading dose is 500 mg and maintenance dose is 125-250 mg. This suggests that lower doses have efficacy.
There is some confusion about Lyme Herxheimer reactions. From experience, Lyme, Babesia and Bartonella have separate and distinct Herxheimer responses. Herxheimer reactions occur when mass killing of chronic, entrenched infection leads to an over-reaching immune response, a cytokine storm. The average, non-Lyme doctor, is unaware of the phenomenon treating mostly acute infections. These same doctors no doubt encounter a fair number of Herxheimer reactions which are misdiagnosed, e.g. drug allergy. Some patients have an "allergy" to every antibiotic. No, they don't. Other patients say, "every time I take an antibiotic it hits me hard."
Babesia and Bartonella Herxheimer reactions are very vexing, chronic and sometimes difficult to manage. They are qualitatively different from Lyme Herx reactions.
Lyme "Herxes" tend to be easier and follow a specific pattern. An antibiotic is introduced, with days severe symptoms ensue, like fatigue (inability to get out of bed fatigue) low grade fevers, brain fog, achiness etc. After a period of days, weeks, usually no more than 3 weeks, symptoms begin to improve and go away and the patient improves. The Herxheimer reaction (Lyme only) should not return in cycles. Such cycles, apparent recurring Herxes, may be the result of normal ups and downs of the disease or due to killing something else other than Lyme. If we add one or more drugs, which gain access to a previously off-limits group of bacteria (round forms, biofilms etc.) a Herx may return, maybe even a more difficult Herx.
Dr. Zhang has dichotomized Lyme bacteria for us: active forms (free spirochetes) and stationary/persister forms (round bodies, biofilms).
After a reasonable amount of treatment with antibiotics targeting both populations, e.g. doxycycline, rifampin and Flagyl we would like to think there are few Lyme bacteria left. We are incorrect.
Add in disulfiram and an intense Herxheimer reaction may ensue (in some cases, not all). Patient tolerance to varying doses of the drug is all over the map. Some handle 500 mg out of the gate, others struggle with 125 every other day.
It makes sense to start with a low dose and gradually increase over time. I am more aggressive apparently than many others. Most patients can increase from 250 mg daily ramped to 500 mg over a week or two. For sensitive patients much lower doses and more gradual ramping is required.
I have seen patients on the border of needing IV antibiotics get better with Disulfiram.
It doesn't always work. There is still no one drug that works for every patient. And symptoms still relapse quickly with discontinuation after a few months. Some patients are still going to need IV antibiotics, (Rocephin, daptomycin, doxycycline) if possible.
In my experience disulfiram doesn't appear to kill Babesia. My experience. Babesia is an opportunistic infection riding on Lyme's coat tail. Lyme has inherent immune suppressing properties. If Lyme is largely gone, Babesia symptoms may abate as well. In a normal host the body's immune system can eradicate Babesia, or reduce it to a mild parasite causing no symptoms. Just a thought.
So far, we only know that Antabuse kills Lyme spirochetes and Staphylococcus. Hopefully research will be funded so we can learn more about the drug. We really don't know what it does or doesn't kill.
Bottom line: Go for it! Monitor labs, watch for side effects (no alcohol including herbal tinctures): disulfiram –is not an overnight miracle cure -- but it is quickly rising to the top of the list of go-to Lyme drugs.
Unecessary suffering and beating a dead horse
My new 40 year old patient is besides herself. She has struggled with a tickborne illness for 5 years. She has managed to keep her job, but barely. She cries uncontrollably. She is very irritable and angry. She complains of anxiety and panic attacks. Mostly, she is depressed. She admits to night sweats. She denies air hunger. Ongoing symptoms include exhaustion, chills, poor sleep, tinnitus, painful lymph nodes, abdominal pain and nausea, GERD, irregular menses, joint pain, headache, dizziness and vertigo and feeling off balance, dysesthesias and crawling sensations, panic attacks, suicidal ideation (no plan or intent), brain fog, trouble with with focus and concentration and thinking clearly. She has had a lot of unexplained abdominal pain over the years.
She has seen 2 "Lyme" doctors off and on over the last 5 years. She has also seen many "regular" doctors. The first Lyme doctor diagnosed Bartonella and treated her extensively with minocycline, azithromycin and rifampin.She didn't get better. A second Lyme doctor confirmed the diagnosis of Bartonella. Laboratory tests were negative but the physician was certain on clinical grounds the diagnosis was correct. After all, what else causes severe GI symptoms and abdominal pain? Anxiety and irritability are typical symptoms, almost diagnostic - she heard somewhere.
The "regular" doctors diagnosed depression, fibromyalgia, chronic fatigue syndrome and hypochondriasis.
One Lyme doctor treated her with ivermectin for one year. She states she thinks she had a Herxheimer reaction but does not know why this drug was prescribed. The treatment did not help.
The same doctor prescribed Biaxin and rifampin. The dose of rifampin was increased to 1200 mg daily. After 9 months of this therapy she has gotten worse. The doctor told her she has not been treated long enough. She decided she has waited long enough. She thinks she had Herxheimer reactions but never got better.
She has never been treated for Babesia or even Lyme. A course of doxycycline with other Lyme drugs was never prescribed -- or anti-Babesia therapy.
A LymeWestern Blot was equivocal by MDL standards, IgG only.
Serologial tests demonstrated a low positier titer for Rickettsia species.
All other serological tests, inclusive of Bartonella and Babesia were negative.
CRP was elevateed at 10.
I am able to offer another test in my CLIA certified blood parasitology lab.
Her an image taken from her Giemsa smear:
If a patient doesn't respond to a therapy the clinician is obligated to go back to the blackboard and take another look.
The slide shows marked infection with the malaria-like red blood cell parasite: Babesia. Few things are black and white in Lyme's orbit. This is an exception.
This CDC endorsed standard malaria/Babesia smear is a gold standard. Many tests circulating in the Lyme-osphere are questionable.
Even without this piece of dramatic evidence, the patient should have been treated for Lyme, e.g. Doxycycline/Ceftin (Tindamax, Flagyl, disulfiram and others) and also treated for Babesia.
This poor long-suffering patient went 5 years, with night sweats and profuse tearfulness (depression) and Babesia was never considered or treated.
Hundreds of things can cause abdominal pain other than Bartonella, etc, etc. The symptoms of Lyme and common coinfections overlap. No one symptom should be attributed to a particular tickborne pathogen.
Babesia treatment includes Zithromax and high doses of Mepron plus Coartem plus Krintafel. It is important to completely knock out Babesia when first encountered. Otherwise, the parasites relapse and return mean and drug resistant. *Please don't use Malarone because Mepron, the yellow paint is hard to stomach. Two malarone twice daily provides a daily Atovaquone dose of 1000 mg. Two tsp of Mepron twice daily provides 3000 mgs of atovaquone, three times the dose. This dose falls within FDA approved, manufacturer guidelines. This high initial dose must be used to avoid drug resistance and years of misery. If its virgin Babesia you have one change to hit it hard and fast. Don't miss.
I am optimistic. We will get her better and sooner rather than later.
Lyme germ warfare?
Complex subjects, like the provenance of Lyme, are oversimplified into a soundbite and the truth is lost in the noise. The Washington Post does us a disservice.
Sam Telford, in the Washington Post told us that Lyme is not an escaped military bioweapon. The headline is an implicit smirk at the alternative Lyme community said to be steeped in unfounded conspiracy theories. Ant-science. Fits right into the IDSA narrative.
Dr. Telford is a smart guy, a professor of Biowarfare at Tufts University, who has researched the topic for decades. Largely, he is telling the truth. Largely.
Let's listen to his truth. It speaks volumes.
Lyme is an old disease, even ancient. Lyme was found in the 5300-year-old ice man dug up from the permafrost in the Alps – previously published in National Geographic. Lyme infected ticks were found from 1945 and 1896 in the northeast US. Facts.
Ticks (Lyme carrying ticks) were studied during the cold war as a means of transmitting germ warfare. Fact.
Deadly agents, including Tularemia and Q fever – transmitted by the same Ixodes ticks were studied (and continue to be an area of research -- other source).
The double helix of DNA was discovered in 1953. Scientists during the cold war (1950s - 1980ish) lacked technology to modify germs and make them more deadly. Now it can be done.
Germ warfare research was done at Fort Dietrich and Plum Island. Modern Biocontainment procedures were unknown. (Animals and Ixodes ticks were allowed to roam free on the Island, with the belief they could not leave the island -- other sources). It was unknown that seabirds could ferry ticks to the mainland.
Lyme and the coming epidemic was something military researches could not have imagined. The Lyme Bacteria was not discovered until 1981.
The Lyme epidemic cannot be entirely sourced to Plum Island since the epidemic broke out in the Midwest and West Coast at around the same time as Lyme Connecticut. The author does not say that Plum Island didn't contribute to the epidemic.
Willie Burgdorfer participated in tickborne biowarfare research for the US Department of Defense.
Dr. Telford says a few dumb and obviously incorrect things: Willie was just joking with the interviewer about his role in germ warfare research. Plum Island was repurposed for agriculture research in 1954 -- during the height of the cold war. (not a cover story).
And -- the US stopped bioweapon research in 1969 because Nixon said so.
These are the clearly established facts.
In summary: Our government was involved in germ warfare research for years. Some of the research involved ticks and tickborne disease (Q fever, Tularemia). Willie Burgdorfer, whose names is attached to the Lyme agent, B. burgdorferi worked for the government and some of this research was with the same ticks that transmit Lyme disease. Biocontainment procedures were unknown and government scientist did not know the ticks and the unknown pathogen (Lyme) could easily jump across the Long Island Sound to Lyme Connecticut.
It is easy to conjecture the Government unwittingly helped spread the epidemic of Lyme disease to New England as an unexpected consequence of secret germ warfare research. And, it is widely known the Government has a habit of not admitting wrong doing and covering its tracks.
When we say Lyme was not an escaped bioweapon the statement is both true and false. There was no conspiracy to infect Americans with a horrible disease. But is seems likely that an unexpected consequence of tickborne disease bioweapon research on Plum Island was the spread of some Lyme infected ticks to the mainland.
The law of unintended consequences applies and there is much we will never know.
Congress can investigate and it will be a waste of time.


text:
package com.mmall.concurrency.example.concurrent;

import com.mmall.concurrency.annoations.ThreadSafe;
import lombok.extern.slf4j.Slf4j;

import java.util.ArrayList;
import java.util.List;
import java.util.concurrent.CopyOnWriteArrayList;
import java.util.concurrent.CountDownLatch;
import java.util.concurrent.ExecutorService;
import java.util.concurrent.Executors;
import java.util.concurrent.Semaphore;

@Slf4j
@ThreadSafe
public class CopyOnWriteArrayListExample {

    // 请求总数
    public static int clientTotal = 5000;

    // 同时并发执行的线程数
    public static int threadTotal = 200;

    private static List<Integer> list = new CopyOnWriteArrayList<>();

    public static void main(String[] args) throws Exception {
        ExecutorService executorService = Executors.newCachedThreadPool();
        final Semaphore semaphore = new Semaphore(threadTotal);
        final CountDownLatch countDownLatch = new CountDownLatch(clientTotal);
        for (int i = 0; i < clientTotal; i++) {
            final int count = i;
            executorService.execute(() -> {
                try {
                    semaphore.acquire();
                    update(count);
                    semaphore.release();
                } catch (Exception e) {
                    log.error("exception", e);
                }
                countDownLatch.countDown();
            });
        }
        countDownLatch.await();
        executorService.shutdown();
        log.info("size:{}", list.size());
    }

    private static void update(int i) {
        list.add(i);
    }
}

redpajama_set_name: RedPajamaGithub


The next evening I lost my cell phone on a bike ride and a friend came by and pounded on the door, to tell me that Kathie, the person who found it, had contacted her. We took a quick ride over and I handed Kathie that old Hopi Prophecy / Eagle has landed Silver Dollar as a finders reward, right as the moon was ascending over our Idaho Mountains.
R.M. said that this "was the full moon, and its conjunct with Uranus meant some sorts of disruptions, unexpected events." Soonafter reading this, I received the bad news that a real antagonist in Panama broke into a house, fought, and killed a man who I used to know. He was the husband of my first boss here in Idaho, the founder of the local Recreation District. They retired a few years ago and moved to Panama; building their new home there, since they liked it so much.
R.M.'s Full moon & Uranus insights got me thinking further about disruption connections. Kathie, the woman who found my phone, was at the first party, I ever attended in Idaho. It was only supposed to be a little get together between co-workers -somebody's birthday I believe, probably late February of '93. Anyhow, this was the first time I met the man who was recently killed in Panama. His wife was my boss and both of them sat across from this same Kathie at a Red Elephant Saloon back table. I arrived late from work and saw a commotion had taken place, right before I walked in. Kathie's wine glass was spilled and my boss was the one who tipped it over! Turns out that Kathie (who has always been quite fit) had made a comment about body weight, which my boss did not take kindly to, so she thrashed out very upset, saying, "Some people just have a harder time than others keeping it off" - or something like that.
Another strange connection is that the person, who pounded on my door to tell me that I would have cell communication again, lives in my old boss's house and has several times cited wild parties she attended there in the old days.
Another weird thing is that right before attending that small work party 15 years back, a young man decided to end his life Hemingway-style via a self-inflicted gunshot on the cross-country ski path, which we were required to clean up without any special safety or biohazard equipment. I'll never forget the police asking us, when we were going to get around to cleaning up the blood drenched snow, as it was upsetting the cross country skiers who were trying to experience leisurely afternoons. The department head also wanted this blood instantly washed from the ski path to avoid bad publicity.
The Supervisor pulled up an old Ford with a snowmobile trailer, to which we commenced walking over with shovelfuls of bloody snow, which we later dragged over; dripping blood to the Valley Gas Station car wash, rinsing red rain down the drain. This bad omen was my first strong indication of how backwards and jaded the community here is. When I later questioned these procedures during a pertinent moment at a Blaine County Sheriff's Search and Rescue meeting, the facilitators there were quick to hush me and said they would address my questions later.
I had a handful of other disquieting experiences while working on the BCRD Trails. First they never provided health insurance, even though that was one of the promises they made when hiring me. Secondly, whenever I suggested some simple ways to improve things, these were either belittled or ignored. For instance, we had a problem with rodents tunneling under the path, which created dangerous caves and holes on the surface, which could cause serious injuries to unsuspecting bikers and rollerbladers. In Northern Virginia the workers seldom cleaned or repaired the bike path, however they did make time to mark the bad spots with bright red spray paint in order to prevent injuries. When I suggested this same solution to our supervisor, he said that we would not disfigure our grand path with red marks. However, several days later, he flipped-flopped, mentioning that one of the board members, Bob Rosso, suggested that we should paint fluorescent red marks around these offending bad spots and then handed me some paint cans, never admitting that I had made the exact same suggestion, merely days before.


The lower level of Stanford Stadium wraps all the way around the field, creating a continuous bowl of nearly symmetrical seating. This creates endzone seating on both sides of the field, although the experiences are wildly different.
The rabid student section cheers on the Cardinal from the south endzone in sections 101-105, while north endzone sections are typically more peaceful and you can get away with sitting for the majority of the game.


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text:
Homes for Sale in Woodstock, Ontario
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Woodstock, Ontario Overview
The City of Woodstock is the seat of Oxford County, located on the Thames River, 40 minutes east of London, Ontario. Woodstock has a wealth of visible history, the town being known for its collection of Victorian-era heritage buildings that are still standing and functional across the city. Attractions in Woodstock include its summer festivals, parks, community spaces, and the Woodstock Museum.
Real Estate for Sale in Woodstock, Ontario
Woodstock was first settled in the early 1800s, its population rapidly growing from immigration to bring the settlement to town status in 1851 and soon after earning the city designation in 1901. As of the most recent census data, over 40,000 people call the City of Woodstock home. The city benefits from being right between London, Ontario to the west and Brantford to the east. A little farther to the east, Hamilton is just over an hour away as well.
Real estate in Woodstock has undergone a lot of changes in the last decade. The current average sale price for 2019 is sitting around $415,000, reflecting a steady increase that heated up around 2016 and is still climbing. That average is made up of detached properties ($445,000), semi-detached properties ($355,000), and condos ($275,000). Within that average, there are some older, smaller homes available in the mid $100,000s and some grand estates that exceed $1,000,000. Most newly-built homes are listed in the $500,000s or $600,000s which is fairly common in this region.
Living in Woodstock, Ontario
Public transportation in Woodstock is provided by Woodstock Transit which runs buses through town as an environmentally-friendly option with a reasonable fair. The buses operate Monday to Saturday, but take time off on statutory holidays. Woodstock Transit buses operate on six different route through the densest areas of the city. Intercity transit is made possible by Via Rail trains which connects Woodstock with Windsor and Toronto.
Schools in Woodstock fall into one of three board options: the Thames Valley District School Board, the London District Catholic School Board, and the Conseil scolaire catholique Providence. The TVDSB also offers public French Immersion programs at some of its elementary and secondary schools. There are thirteen elementary school options and five secondary schools across the three boards. The only post-secondary institute in Woodstock is a campus of Fanshawe College. In addition to its program offerings, the college campus also offers a chance to earn Ontario High School credits at its "School Within a College".
Woodstock has a lot of community opportunities to offer both new and longtime residents. From the public rinks at the Woodstock Community Centre, to fascinating local history at the Woodstock Museum, to vibrant community celebrations, there is always something to do on the weekend. Unique to Woodstock is COWapolooza - more than just a clever pun, the City of Woodstock's summer festival celebrates town heritage and modern community in one weekend event. Woodstock was once known as a major dairy capital in Ontario, a tradition carried on by COWapolooza's Cow Milking Contest. In addition to vendors and attractions, the festival also features musical acts on Friday and Saturday night.
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text:
Ultraviolet light-induced collagen degradation inhibits melanoma invasion
Budden, T. et al. (2021) Ultraviolet light-induced collagen degradation inhibits melanoma invasion. Nature Communications, 12, 2742. (doi: 10.1038/s41467-021-22953-z) (PMID:33980846) (PMCID:PMC8115293)
Ultraviolet radiation (UVR) damages the dermis and fibroblasts; and increases melanoma incidence. Fibroblasts and their matrix contribute to cancer, so we studied how UVR modifies dermal fibroblast function, the extracellular matrix (ECM) and melanoma invasion. We confirmed UVR-damaged fibroblasts persistently upregulate collagen-cleaving matrix metalloprotein-1 (MMP1) expression, reducing local collagen (COL1A1), and COL1A1 degradation by MMP1 decreased melanoma invasion. Conversely, inhibiting ECM degradation and MMP1 expression restored melanoma invasion. Primary cutaneous melanomas of aged humans show more cancer cells invade as single cells at the invasive front of melanomas expressing and depositing more collagen, and collagen and single melanoma cell invasion are robust predictors of poor melanoma-specific survival. Thus, primary melanomas arising over collagen-degraded skin are less invasive, and reduced invasion improves survival. However, melanoma-associated fibroblasts can restore invasion by increasing collagen synthesis. Finally, high COL1A1 gene expression is a biomarker of poor outcome across a range of primary cancers.
A.V. is a Wellcome Beit Fellow and personally funded by a Wellcome Trust Intermediate Fellowship (110078/Z/15/Z), and has work funded by Cancer Research UK (A27412) and Leo Pharma Foundation. E.N. is funded by Fondo de Investigación en Salud (FIS) PI15/01860, Instituto Carlos III, Spain. C.G.-M. funded by the French Dermatology Society, Collège des Enseignants en Dermatologie de France (CEDEF) and UNICANCER France. S.J.F. acknowledges support from the European Commission (FP7-PEOPLE-2013-IEF—6270270) and the Royal College of Surgeons in Ireland StAR programme. P.M. is funded by the Manchester Cancer Research Centre, supported by the CRUK Manchester Institute.
Zanivan, Professor Sara and Kay, Emily
Budden, T., Gaudy-Marqueste, C., Porter, A., Kay, E., Gurung, S., Earnshaw, C. H., Roeck, K., Craig, S., Traves, V., Krutmann, J., Muller, P., Motta, L., Zanivan, S., Malliri, A., Furney, S. J., Nagore, E., and Virós, A.
First published in Nature Communications 12: 2742


text:
School board votes to cover controversial mural rather than paint over it
Board faced intense political backlash, threat of a ballot measure and lawsuit
By Laura Waxmann S.F. Examiner Staff Writer • August 13, 2019 7:50 pm - Updated August 14, 2019 11:06 am
A mural at the center of a national debate over the value of preserving public art memorializing historical oppression will remain intact but covered from the view of students at George Washington High School, the San Francisco School Board decided with a 4-3 vote on Tuesday.
In June, the board unanimously voted to paint over the mural to address the concerns of black and brown students, their families and some teachers at the school who found the 1936 mural, which depicts slavery and genocide, offensive and traumatizing.
That decision, however, elicited an intense backlash from arts preservationists and members of the high school's alumni association — who have likened the move to censorship and even threatened to place the issue before San Francisco voters by way of a ballot measure next year. The mural itself, supporters note, was intended by the artist as a critique of the dark side of American history and not a glorification of it.
The resolution the board voted on Tuesday — a compromise proposed Friday by Board President Stevon Cook — instead calls on San Francisco Unified School District staff to assess "a range of alternatives" while developing a project that removes the mural from public view "using solid panels or reasonably similar equivalent material, means or methods."
The resolution passed, with commissioners Gabriela Lopez, Alison Collins and Mark Sanchez voting against it.
"I don't get why people are standing up for this. There are black and brown boys dying. People are making noise about this [mural] and I'm confused — is this a smoke screen?" said Commissioner Faauuga Moliga, who initially voted to paint over the mural but on Tuesday said that he wanted to throw his weight behind more pressing issues affecting the district.
"I'm here today because I have had to choose my battles, as much as it breaks my heart to go the route I need to go — tonight I need to support the recommendation put out by the district," he said.
District staff had initially recommended the board move to cover the mural, but board members amended that proposal this summer to instead paint over it completely.
The cost of painting over the mural was estimated at about $600,000, due in part to the expected expense of conducting a legally required environmental impact report. The cost of covering it with panels or textile was estimated at between $375,000 and $825,000. Funding would likely come from the district's deferred maintenance program or general obligation bond program.
An amendment in the initial vote left room for the board to reverse course and physically cover the mural in another fashion should painting over it "result in an undue delay." On Tuesday, the board determined that would be the case.
The process of covering the mural with panels will still have to undergo a mandated environmental review, as prescribed by the California Environmental Quality Act.
Minutes before the board's vote, Commissioner Alison Collins introduced an amendment to the resolution that would have allowed the district to explore removing the entire wall that holds the controversial panels of the fresco mural called "Life of Washington," which among other things show slaves shucking corn and colonists towering over a dead Native American. Other panels of the mural show indigenous people with scalps attached to their waists.
The amendment failed to gain enough support among the board members. Cook indicated prior to the hearing that removing a wall within the school could cost as much as $5 million.
Collins said that the debate over the mural "may seem like a frivolous issue but this is an example of the fight we have ahead of us if we really want to remove structural racism and white supremacy from our educational system," and stood firm behind her belief that the mural should be removed from the school.
Earlier this year, the district convened an 11-member community advisory committee to address "longstanding public concerns over objectionable content depicted in the 13-panel mural, which was commissioned by the U. S. Government in under a New Deal era art program.
Protests over the mural's contents date back at least 50 years, and in the 1960s inspired a series of response murals within the school highlighting the achievements of black and brown communities.
Victor Arnautoff, the Russian artist behind the mural, painted using the fresco technique, a method done on wet plaster that makes the image an "integral part of the wall it was painted on," the district said. The committee supported permanently removing the "offensive content of the mural" by painting over it.
Supporters of the effort to paint down the mural on Tuesday condemned the board for backtracking on its unanimous decision to paint over it.
"We participated in good faith and believed there was honesty and integrity in your process. But here we are with the all too familiar feeling of broken promises," said Mary Travis Allen, an indigenous elder. She reminded the board of its obligation to provide a "safe and healthy" learning environment for all students.
Students who spoke at past board hearings and again on Tuesday attested to feeling uncomfortable with the mural's imagery.
"Over 2,000 students have to go to this school every day and should never have to hear, 'I'll meet you at the dead Indian.' We deserve respect," said George Washington High School junior Sharez Brown.
An advocate said the mural's supporters have few ties to the school's community, other than membership in its alumni association.
It is unclear whether the Coalition to Protect Public Art, which threatened to bring the issue to the March 2020 election, will drop efforts to pursue a ballot measure. The group's executive director, Jon Golinger, indicated in a statement on Friday that the group continues to oppose putting up an impenetrable barrier that blocks anyone from seeing the murals.
"While it is certainly a step in the right direction to take destruction off the table we will continue to strongly oppose spending $825,000 to permanently wall off the murals so nobody ever has the choice to see them, debate them, or learn from them," said Golinger in a statement to the San Francisco Examiner.
"In the coming days we will evaluate this decision, consider all political and legal options, and decide how best to proceed to ensure a wide range of options is considered to achieve a resolution that protects both students and public art," he said.
In recent weeks, the campaign to preserve the mural has gained support from the local chapter of the NAACP and actor Danny Glover, who attended Washington High School. In a statement on Monday, Glover condemned the "horrors of human bondage and the mistreatment of native peoples," and said the mural served as a reminder of the country's unsavory past.
He also likened blocking the murals from view to "book burning."
"To destroy them or block them from view would be akin to book burning. We would be missing the opportunity for enhanced historic introspection this moment has provided us," Glover said.
Commissioner Gabriela Lopez, who on Tuesday voted against covering the mural with panels and pressed for it to be painted over, pointed out that the historical oppression showcased by the mural will continue as long as the voices of those most impacted by it on a daily basis are being silenced.
"The argument that students aren't affected shows me that you're not listening to students coming here demanding the mural's removal for decades," said Lopez. "The argument that this is the only way to teach about racism leads me to believe that you don't understand education."
Amy Anderson, the mother of a Native American student at the high school who three years ago revived conversations about how it was impacting students in the present day, told reporters after the vote that she is sympathetic to the board's decision to shy away from painting over the mural, but would continue to push for its removal from the school.
"I understand that this mural issue has created so much attention that the superintendent and school board have not been able to get work done on major items that are very important and related to all students in our school district. I also understand that I am not going away," said Andersen, adding that she has received threats due to her advocacy.
"My son and I have felt very outnumbered," said Anderson. "This is not stopping for us. Were going to stay in it until we see that social justice is truly a core value and it is acted upon in our school district and that one day, the mural will be painted down."
lwaxmann@sfexaminer.com
This is a breaking news story, please check back for updates.
Tags: Bay Area News, education, Politics, san francisco news


For some Master's degree programs, and all Ph. D. programs, require some type of thesis or dissertation for completion. This is one of the most important steps in attaining a higher-level degree, and it requires significant time and research to complete. A thesis must investigate something concerning your field, and demonstrate expansive research. Then, these works must be defended in front of an examining committee. This is generally a time of high stress for students, and writing the introduction is often the hardest part. The first choice you will be faced with it picking a subject. When thinking about what you want to write, make sure it's something that interests you, but that you can research with relative ease. You're going to be with this subject for a long time, and it really helps if you genuinely enjoy the topic.
First of all, relax. Writing a thesis is a long and involved process, but it doesn't have to be overwhelming. Approach your thesis confidently, as this is the culmination of your education thus far, and you are well-versed in your area of study. If you're having difficulty choosing a topic, there are many steps you can take to facilitate this process. Firstly, do your research. If you don't have a topic picked, keep abreast of past and current publications regarding your area of study. This will not only help you have a well-rounded wealth of information, but it can help to inspire a great idea of your own. Additionally, take advantage of the resources provided you. Keep an open dialogue with the members of your thesis committee, as they can help lead you to your topic. These are the people who will be overseeing your progress, and they want to see you succeed; do not hesitate in picking their brains when writing your thesis introduction, that's what they're there for.
Once you have your topic and are ready to write, introduce the topic in a way that gets the reader's attention. This will set the tone for the rest of the work, and will be appreciated by those both reading and listening to your argument. A working title should also be created, and a hypothesis or research question should be formulated. This will be the basis of your thesis, and all research will be made to support your main argument. Then you need to create a description of the argument you will be making, and the description of the type of research will be used. It's important to remember to proofread and edit every step of the way, and try to get others to read your introduction and provide constructive criticism. When writing a thesis introduction, it is also highly recommended to have an outline for the thesis; this will help you stay focused and organized. Your introduction will set the tone to the rest of your thesis or dissertation, which is the crowning achievement of your education and this step will help you attain your goal of higher education.


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Cheryl Dunye (* 13. Mai 1966 in Liberia) ist eine US-amerikanische Filmregisseurin, Filmproduzentin und Drehbuchautorin afroamerikanischer Abstammung.

Leben
Dunye schloss ihr Studium an der Temple University in Philadelphia 1990 mit einem B.A. ab. Danach studierte sie an der Mason Gross School of the Arts der Rutgers University in New Jersey, wo sie 1992 den M.F.A. erhielt.

Sie wurde Hochschullehrerin an der UCLA. Des Weiteren wurde sie als Filmregisseurin und Filmproduzentin tätig. Sie drehte und produzierte seit Anfang der 1990er Jahre mehrere Filme. Dunye lebt offen lesbisch und ist Mutter zweier Kinder.

Filmografie (Auswahl)
(als Filmregisseurin)
 1990: Janine
 1991: She Don't Fade
 1992: Vanilla Sex
 1993: An Untitled Portrait
 1993: The Potluck and the Passion
 1994: Greetings from Africa
 1996: The Watermelon Woman
 2001: Stranger Inside
 2004: My Baby's Daddy
 2012: Mommy is Coming
 2019: Dear White People (Fernsehserie, eine Folge)
 seit 2020: Lovecraft Country (Fernsehserie, eine Folge)

Auszeichnungen (Auswahl)
 1996: Teddy Award für The Watermelon Woman
 2002: Audience Award und Special Mention beim Créteil International Women's Film Festival für Stranger Inside
 2003: Herb Alpert Award in the Arts, Film/Video Nominee
 2004: Community Vision Award, National Center for Lesbian Rights
 2012: Feminist Porn Award 2012

Einzelnachweise

Weblinks
 Offizielle Webseite von Dunye

Drehbuchautor
Filmproduzent
Filmregisseur
Hochschullehrer (University of California, Los Angeles)
Liberianer
Geboren 1966
Frau

redpajama_set_name: RedPajamaWikipedia


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Photo: Abner Kingmann / ACEA
And finally....
Protocol for the 35th America's Cup is finally published
Tuesday June 3rd 2014, Author: James Boyd, Location: United States
"We're going to have our work cut out for us, that's for sure." So says Oracle Team USA skipper Jimmy Spithill as he assesses the competition for the 35th America's Cup.
Today, the Protocol was released, which defines the rules, format and commercial regulations for the 35th America's Cup. Entries open on 9 June and close on 8 August, 2014, giving prospective teams two months to enter.
The Class Rule for the new AC62 yacht, which has already been shared with teams in draft format, will be issued in the coming days, prior to the entry period opening.
Highlights of the Protocol include:
- A three year racing program from 2015 to 2017 with every race counting towards qualification and/or points in the final America's Cup Match
- At least six America's Cup World Series events per year in 2015 and 2016 to be raced in the AC45 class. All teams have an opportunity to host an event in their home country
- An America's Cup Qualifiers series in 2017 involving all teams, with a bonus point in the America's Cup Match at stake
- America's Cup Challenger Playoffs for the top four challenger teams to emerge from the Qualifiers
- The America's Cup Match, featuring the defender, Oracle Team USA against the top challenger. The first team to win 7 points will win the America's Cup
- Up to two Youth America's Cup events providing a pathway for young sailors to join the top rank of professionals
- The new AC62 yacht – a foiling, wing sail catamaran sailed by 8 crew – to be raced in all events in 2017
- A crew nationality rule requiring at least 25% of the AC62 crew to be nationals of the country of their challenge
The Protocol was negotiated between defending champion Oracle Team USA and its Golden Gate Yacht Club and Team Australia's Hamilton Island Yacht Club, the Challenger of Record.
The 35th America's Cup builds on the successful elements of the last America's Cup – fast, exciting racing in foiling multihulls that is challenging for the best sailors in the world and appealing to spectators.
"We are convinced the 35th America's Cup will surpass previous events in almost every way: more challengers, amazing new boats and a competition structure that will engage and enthrall people over a three year period," said Mat Belcher, the skipper of Team Australia, the Challenger of Record.
For his part, Spithill is aware that a stronger group of challengers will make it that much more difficult for his team to hold on to the Cup.
"It's the America's Cup, so it's not supposed to be easy, but our goal is to make it a three-peat," says Spithill, who led his team to victory in 2010 and 2013. "It was so close last time. Battling back to win from being down 8-1 is something we will never forget and I expect it will be just as difficult this time."
The entry period is open from 9 June until 8 August 2014.
Read the full Protocol document here
Chr1s 04/06/2014 - 11:39
Do we have a venue yet?
Oracle Team USA
Team Australia
James Spithill
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text:
Home / Essay Examples / Literature / The Yellow Wallpaper / Symbolism in the Yellow Wallpaper
Symbolism in the Yellow Wallpaper
Storytelling , The Yellow Wallpaper
In Charlotte Gilman's short story "The Yellow Wallpaper," the storyteller is found at the highest point of an old home in a room decorated in a yellow wallpaper. The lady depicted had recently given birth to a child but is presently experiencing what she describes as a "nervous condition.As the lady stays in the room, she becomes fixated on the yellow wallpaper of her room. Inside the strict components of the story are images that demonstrate the hidden message of the story such as the references to the yellow wallpaper, the home, and even writing in her notepad. "The Yellow Wallpaper," symbols are given that portray the message's underlying meaning within the precise factors of the story such as the room, writing in her notebook, and the yellow wallpaper. Understanding Jane's experience as that of a Lacanian-diagnosed psychotic foreshadows Gilman's dismissal of the Victorian obsession with presiding over normality and further explains the complexities of Gilman's representation. The narrator writes in her note-pad all through the story, keeping it secret from her family, and taking it out only when they leave the room.
What Does the Journal Symbolize in The Yellow Wallpaper
The journal symbolizes a trace of stableness in, what is by all accounts, a profoundly persecuted life of the storyteller. One case of said abuse is evident in the story when the narrator proclaims, "There comes John, and I should put this away,he would rather not have me say a word." As the story closes and the storyteller has began to end her composition sessions, she goes crazy. The room that the storyteller is remaining in is all by itself at the highest point of the house, and has nothing but a bed that is nailed to the floor and the yellow wallpaper that she shows a strong distaste for, which is evident in the text when she describes it as repellent, almost revolting: a smoldering unclean yellow, strangely faded by the slow-turning sunlight. It is a dull yet lurid orange in some places, a sickly sulphur tint in others. This wallpaper symbolizes the constraint of the storyteller by her spouse, and in the long run, opportunity from said restraint. This room, which is secluded from other parts of the house, seems to be her place to write when she is alone; however, she trusts that her spouse's sister "supposes it is the composition which made me wiped out. The essayist may gather from the previous statement that the separated room is an image of a place of refuge for theher. She was endeavoring to wrap up the wallpaper back to remain behind it and the room was her solitary thing keeping her family out.
Despite the fact that the storyteller was crazy at this point, the reader can gather that by securing herself in the room and her family out, she felt safe there. When asked about repapering the room by his wife, John would only give concocting reasons. He realized that she was resentful about the paper and still would not transform it. Many would argue that John is a patriarchal bully because of this. However, many people also fault the narrator for her illness, seeing her not as un-obedient but rather submissive to her doctor/husband. The storyteller's announcement that "regardless of you and Jane. Furthermore, I've pulled off the vast majority of the paper, so you can't return me" demonstrates that she has understood that the wallpaper was simply a way her husband persecuted her from life, and by in removing herself from the four yellow walls, she is able to be free. But while Jane's interpretation holds some value, it fails to take consideration into the many instances in which Jane displays a strong fighting spirit against John's medical advice.
With respect to writing in her notepad, some may question that symbolizes defiance, rather than security. Others may consider that the yellow backdrop symbolizes the storyteller's mental instability, and not constraint. Despite the fact that the focuses expressed are coherent to a degree, there are grounds to adopt an alternate strategy to the imagery of said images. The individuals who trust that the narrator's room is an image of detainment may see the room along these lines as a result of its dullness, the way that the bed is fastened to the floor, and the truth of the storyteller not being allowed to leave the room. What readers need to see is that the room isn't detaining the storyteller, her husband is. The room symbolizes security for the storyteller in light of the fact that, as expressed beforehand, the room is the only space where the woman can write and think on her own.
"The Yellow Wallpaper, written by Charlotte Gilman, depicts a lady who is gradually going crazy and suffers from a psychological breakdown at the store's end. Subsequent to analyzing the short story, basically, one must notice the utilization of imagery in the story. The detached room that the storyteller remains in symbolizes an asylum, giving the narrator time to compose when her family is away. The storyteller writing in her notepad symbolizes the dependability in the their life that gradually disintegrates as the story closes. Last, but not least, the awful yellow wallpaper symbolized the abuse that the storyteller experiences from her husband, and when at last evacuated, the opportunity. The images shown in "The Yellow Wallpaper" give the story a more grounded basic significance, and to the narrator, by her, a feeling that she was not totally insane, but rather a woman who discovered freedom in something as monstrous as a yellow wallpaper.
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