text:
Customer Service Team of the Year – Computer Services & Software – SIOS Technology
< 1 minutes
These are the Gold, Silver, and Bronze, Stevie® Award-winning nominations in The 2022 American Business Awards®. The winners were determined by the average scores of more than 230 professionals worldwide in the three-month judging process. Learn about the judging and awards process here.
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text:
Cooking Class Milan
Online Pizza Course
Pizza Cooking Class
Bread Cooking Class
Categorie Seleziona una categoria Bread (1) Gallery (2) Pasta (1) Pizza (3)
Privacy policy Pizzaskill.com
This Privacy Policy has been updated 21 March 2019
Our Privacy Policy guarantees compliance with the EU General Data Protection Regulation, which will come into force on 25 May 2018:
Pizzaskill.com respects your privacy and wants to help you understand how we collect, use and share your information. This privacy policy covers data collection and describes your rights to access and correct your personal information or to limit its use. This privacy policy applies when you visit or use the website, mobile applications, related APIs or services.
By using the Services, you agree to the terms of this Privacy Policy. Do not use the Services if you do not agree to the Privacy Policy or other agreements that govern the use of the Services.
We collect some data directly from you, including the information you enter, the data relating to the courses you follow and the data from third-party platforms to which you connect with Pizzaskill.com. We also automatically collect certain data, such as information about your device and the parts of our Services that you use or interact with.
Data provided directly by you
Account data:
In the event that you should create a personal account, use the Services or subscribe to the newsletter list,we can collect various data from you or about you even through a third-party platform, including for example: in order to use some features (for example, signing up for a course,book a consultation,or any other method of communication with Pizzaskill.com), you might create a user account,or release contact details such as e-mail phone number or other. When you create or update your data, we can collect and store the data you provide, such as your e-mail address, your password, your gender and your date of birth,or other, and we can assign you a unique identification number ("Personal Data"). 'account 'or can add you in a newsletter list or other commercial lists.
Profile data:
If you consider it important, you could add data for an hypothetical profile, such as a photo, a title, a website link, social media profiles or other data. Everything you could add to the profile could be publicly visible and could therefore be viewed by other users.
Shared content:
Some parts of the service could give you the opportunity to interact with other users or allow you to give your opinion about various articles or comments. These shared contents could be publicly visible, depending on where they were published.
Course data:
When and if you will have the opportunity to enroll in a possible course proposed by Pizzaskill.com, we could collect certain information such as the course and other materials sent to meet the requirements of the course.
Payment data:
If you have the opportunity to buy an online Pizzaskill.com course or other services, we could collect some data on your purchase (for example, your name and zip code etc.), which are necessary to process the order. For security reasons, Pizzaskill.com does not collect or store sensitive data on credit cards, such as the complete card number or the authentication data of it.
You can link your PayPal account to the Services, or another service to make your payments. When you will link a payment account, we could collect and use certain information, including the e-mail address of your account, the account ID, the physical address and other data we will need to identify payments from your account. For security reasons, Pizzaskill.com does not collect or store sensitive data on bank accounts.
Your account data on other services :
If you access Pizzaskill.com through Facebook or another platform or another third party service, we could ask for your permission to access certain information on the other account in question.
These platforms and services allow us to access this information via the APIs they use.
Pizzaskill.com could send you a promotion (such as a contest,or other promotional events) through the Services or through a third-party platform; the data you will submit is subject to this Privacy Policy, unless otherwise specified in the official rules of the promotion or in another privacy policy to manage the promotion or survey.
Communications and support:
If you will contact us for support or to report a problem or doubt by email hello@pizzaskill.com or other connection way, the data collected could be used to answer you and to examine your question or doubt under this Privacy Policy.
Data that we could collect through automated tools:
When you access the Services (even just to consult the courses), we could collect some data through automated tools that include:
System data: device type IP address, operating system type and version, device unique ID, browser, browser language, domain and other system and platform data.
Use statistics on your interactions with the Services
Geographical approximation data:
Approximate geographic location based on your IP address.
How we could collect the data
For the collection of the aforementioned data, Pizzaskill.com could use tools such as cookies, web beacons, analysis services and advertising service providers. Some of these tools could allow you to disable data collection.
Cookies and data collection tools
In the event of access or use of the Services, Pizzaskill.com and Service Providers acting on your behalf (such as Google Analytics and third-party advertisers) could use server registers and tools for automatic data collection, such as cookies, tags, scripts , custom links, device or browser fingerprints and web beacons. The data collected will be carried out according to the procedures described in this Privacy Policy.
You can eventually set your browser to be notified in the event of attempts to enter cookies on your computer, limit the type of cookies allowed or refuse them altogether. In this case, however, you could not be able to use some or all of the features of the Services and your experience could be different or less functional.
Cookies are small text files that are stored by the browser while you surf Internet, used to collect, store and share data about your activities on websites and also allow us to remember certain elements of your visits on Pizzaskill.com, for example your preferred language, or the country you are in to make it easier for you to use the site.
Cookies help to authenticate your access to Pizzaskill.com and prevent unauthorized parties from accessing your possible accounts.
Cookies could help us show you a personalized list of recommended courses or articles on the home page.
We often could use both session cookies, which are used to identify you during a single browsing session that expire after a short period or when you will close the browser, and persistent cookies, which are used to identify you over a longer period of time, for example when ask us to keep your access. They remain stored in your browser for a predefined period of time.
We could use these cookies when you visit our site and our services both via browser and via possible mobile app.
You could change your browser settings to refuse cookies, but you may not be able to access, customize or use some interactive features of the Services.
For general information on targeting cookies and how to disable them, visit www.allaboutcookies.org.
Pizzaskill.com believes it can periodically update this Cookie Policy. In this case, we will notify you by publishing the policy on our site with a new effective date.
In its Services, Pizzaskill.com could use third-party analysis services for browsers and mobile devices, such as, for example, Google Analytics, Hotjar and Intercom. These services use data collection tools that allow us to analyze your use of the Services by providing information on the movements on the web you have made to access the site; this allows us to better understand the operation of the Services on the various devices and provide information that may interest you.
We could use third-party advertising services for our advertising of the Services on other websites or other applications you use. Advertisements can be based on your recent activity or on the activity carried out over time on other sites and services and can be customized in based on your interests. Depending on the type of advertising service used, it is possible that cookies or other tracking technologies could be inserted into your computer, phone or other device to collect data on your use of the Services. If you use mobile applications, you could also receive personalized advertisements- app.
As for the other devices and operating systems, we advise you to consult your privacy settings or contact your platform operator.
For what purposes we could use data
We could use the data we collect through your use of the Services to:
offer and manage the Services, for example to view personalized content and facilitate communication with other users;
process your requests and orders regarding courses, products, specific services, information or functions;
communicate with you about your possible account:
answering your questions and your doubts;
mailing you messages and information of an administrative nature, notifications of changes to the Services and updates to our agreements;
forwarding you information and in-app messages about new services, new features, promotions, newsletters and other available courses (which you could deactivate at any time);
sending push notifications to your device to provide you with updates and other important messages;
to facilitate the technical functioning of the Services, including the resolution of problems, the securing of the Services and the prevention of fraud and abuse;
request user feedback;
distribute and administer possible surveys and promotions managed or sponsored by Pizzaskill.com;
learn more about you by linking your data to other information through third-party data providers or analyzing data with the help of analytics service providers;
uniquely identify users on various devices;
customize advertisements on various devices;
improve the Services and develop new products, services and functions;
analyze trends and traffic, track purchases and track usage data;
advertise the Services on third-party websites and applications; in accordance with what is required or permitted by law;
as deemed necessary by Pizzaskill.com, in its sole discretion, to ensure the security or integrity of its users and employees, third parties, the public or its Services.
With whom we could share the data
Pizzaskill.com could share your data with third parties in the following circumstances or as otherwise described in this Privacy Policy:
With service providers, collaborators and agents: we could share your data with third-party companies that perform services on our behalf. These service providers could access your personal data and have the obligation to use them exclusively according to our directives, to provide the service requested by us.
With business partners: We could have agreements with other websites to expand our services and direct traffic to Pizzaskill.com. Depending on your location, we could share your data with these partners.
With data analysis and enrichment services: Using third-party analysis tools and data enrichment services we could share some contact information, or data made anonymous, depending on the case. Anonymized data means data in which we have removed items such as your name and e-mail address to replace them with a token ID. All this allows us to communicate with you in a more effective and personalized way.
To improve the social media functions: The social media functions of the Services can allow the third party provider to collect elements such as your IP address and the page of the Services you are visiting and to set a cookie to enable the function. Your interactions will depend on the third party's privacy policy.
For advertising purposes: If Pizzaskill.com decides to offer advertising in the Services in the future, it could use and share some System Data and Usage Data with third party advertisers and with third-party networks to show general information of our users. Pizzaskill.com could also allow advertisers to collect data to deliver personalized ads and make your user experience even more unique.
Please note that if you do not grant your authorization, you will continue to receive generic advertisements.
For security and compliance reasons: Pizzaskill.com reserves the right to disclose your possible data to third parties if (in its sole discretion) it believes in good faith that the disclosure is:
permitted or required by law in a judicial, legal or governmental context; following a mandate or appearance;
reasonably necessary for the application of our Terms of Use, this Privacy Policy and other legal agreements;
request to resolve cases of fraud or violation of the law (or rules / regulations) and / or technical or security problems or to ensure protection from imminent damage to the rights, property or safety of Pizzaskill.com of its users and employees , of members of the public and / or of the Services.
Pizzaskill.com could also disclose possible data about you to its auditors or legal advisors to evaluate your rights and / or disclosure obligations pursuant to this Privacy Policy.
With your authorization: with your consent, Pizzaskill.com could share data with third parties for purposes beyond the scope of this privacy policy.
Pizzaskill.com could adopts adequate security measures to guarantee protection against unauthorized access or modification of sensitive data; on the Internet, there is always the risk of unauthorized access, unfortunately, however, no system is totally secure, so it is not certain that the data supplied by the user may be immune to unauthorized access by third parties. It is therefore important to protect your password, it is your responsibility to protect it properly and promptly report any suspected unauthorized access to your possible account. If you believe that this or your possible account has been compromised for any reason, immediately change it and write to hello@pizzaskill.com to present your case.
You have been given certain rights to your data, such as updating or closing your possible account directly from the Services, you could eventually contact us for requests about your rights regarding your personal data. Parents who believe that Pizzaskill.com has unintentionally collected personal information about their minor children should contact us to help us eliminate this possible information.
You could choose not to provide certain data to us, but in this case you may not be able to use certain features of the Services.
If you do not wish to receive our promotional communications, you could report it, but Pizzaskill.com reserves the right to update you by sending you messages about administrative confirmations, order confirmations, important updates on the Services and warnings about our policies.
For any questions about your possible data, our use of your information or your rights, please contact us at hello@pizzaskill.com.
About any problems closing your account, send us an email or contact our Support Center always by email on hello@pizzaskill.com.
Note: even after your possible account has been closed, it is possible that some or all of your data will continue to be visible to others. Pizzaskill.com could keep your data until deemed necessary for any legitimate purpose and in accordance with applicable law.
Pizzaskill.com could store and disclose such data under this Privacy Policy even after your possible account has been closed.
We recognize the importance of protecting the privacy of minors and invite parents and guardians to play an active role in controlling the online activities and interests of their children. Children under the age of 13 (or 16 in the European Economic Area) are not allowed to use the Services. In the event that we learn that we could have collected personal data from people under the age of those indicated, we will take all reasonable measures to eliminate them. If a parent or guardian deems that this data has been entered, he can contact the Pizzaskill.com service center to remove it.
Rules on jurisdiction
Please note that Pizzaskill.com could transfer the data entered by users residing in countries such as: India, Australia, Japan, China, Indonesia, Mexico, Brazil, United States, Canada, South Africa, European Union, Russia, in areas beyond out of them.
By visiting or using our Services, you give your consent to the storage of your data on our servers and your consent to the transfer, storage and processing of your data in other countries outside of yours. Such data could be also processed from the companies of the Pizzaskill.com group or from our service providers for various purposes. By providing us with your data or using our Services, you consent to the transfer, storage and processing of your data by Pizzaskill.com and its agents.
Since the Internet industry is still working on the development of Do Not Track standards, solutions and implementations, we currently do not recognize or respond to Do Not Track signals coming from browsers.
Updates and contact information
In the event that we make a change to this policy, we could inform users via e-mail, or through another mechanism required by law.
The changes could take effect from the day of their publication. We remain available by e-mail for any clarification.
If you continue to use the Services after a change comes into effect, your access and / or use of the Services will be considered as an implicit acceptance of the modified Privacy Policy and the obligations arising from it. The modified version replaces all previous versions of the Privacy Policy.
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redpajama_set_name: RedPajamaCommonCrawl


text:
El Chapo's 'Unforgiveable' Escape
When Mexico's president thought the drug lord was locked away for good, he told me letting him get away would be unpardonable. And now?
Leon Krauze
Updated Apr. 14, 2017 10:17AM ET / Published Jul. 15, 2015 2:05PM ET
Edgard Garrido / Reuters
MEXICO CITY — Mexican President Enrique Peña Nieto was smiling. "This has made me very happy," he told me. It was late February 2014, and Peña Nieto had every reason to be pleased. After all, Mexican navy commandos had just caught the world's most wanted drug trafficker, Joaquín "El Chapo" Gumzán, after almost a decade and a half on the lam. Now, the infamous "Chapo" (Shorty) was behind bars, imprisoned in Mexico's Altiplano maximum-security federal prison, no less. Yes: Peña Nieto had every reason to smile.
Univision news, where I am a correspondent and anchor, had booked the interview weeks before Guzman's capture, after Peña Nieto landed on the cover of Time magazine under the banner "Saving Mexico." As luck would have it, we met less than 100 hours after the "arrest of the century."
Far from the norm, Enrique Peña Nieto seemed eager to talk. I asked him how he had found out that Guzmán had been captured.
Framed by a Mexican flag and looking dapper in a navy suit, Peña Nieto shuffled a little bit in front of the camera. And then he began recollecting.
"I was wearing jogging clothes because I was about to go for a run. But then the news came and altered my morning's plans," he said, laughing. "I knew we had come close to catching him before. We had found people closely associated with this criminal. We had found his hiding place as well. We just didn't know when it was going to happen and so it was particularly rewarding to wake up so early to such happy, satisfying news."
The president paused a bit, taking the moment in.
I asked him about the possibility of extraditing Guzman to the United States, where he would face a long list of charges and, quite probably, years of uncomfortable incarceration: no wine, women, or relaxing quarters, such as Guzman famously enjoyed during his stint at Puente Grande, the prison he had escaped from in a laundry cart in 2001.
The question made Peña Nieto slightly uncomfortable. Like others within his administration, the president didn't like to the idea of handing Guzmán over to the Americans. Peña Nieto's attorney general, Jesús Murillo Karam, would later say, with classic nationalistic arrogance, that Chapo might end up in the United States "after he has served 300 years in Mexico."
The president struck a similar, if slightly more diplomatic, chord. "This criminal has to face Mexican justice," Peña Nieto told me, jaw clenched: "He has to face the process that's already in place here. Of course, this doesn't mean that he could eventually, at some later time yet to be decided, be extradited. But for now, he has to stay here and face our system of justice."
In other words, Chapo was Peña Nieto's prize and he intended to keep him.
I then asked a question that would come back to haunt the president just a year and a half later.
As luck would have it, a poll had been published just a few hours after Guzman's capture, and almost 70 percent of those polled said they thought Guzmán would escape again, as he had done in 2001.
I ran the numbers by Peña Nieto and asked him if he would promise that, indeed, Guzman wouldn't break out of jail again.
Peña Nieto didn't hesitate. "It is the duty of the Mexican government, especially after what happened in the past," he said, emphatically: "Allowing something like that to happen is truly regrettable, it's unforgivable."
"So it's a pledge?" I insisted.
"Look," he said, "I talk to the Interior Minister every day and ask him if we're watching [Guzmán] closely, if we're sure he's being watched closely. It is the Mexican government's responsibility to make sure that what happened a few years ago never, ever happens again," he concluded, as if describing the impossible.
But, of course, it did happen again, it has happened again. Just 16 months after that conversation, Joaquín Guzmán escaped through an impossibly long and sophisticated tunnel dug right under the Altiplano prison, Mexico's equivalent to America's supermax penitentiary in Florence, Colorado. The scale of the project is beyond fiction. That no one knew about it is also beyond belief: scaffolding, lighting, oxygen tanks…even a motorcycle mounted on rails to expedite el Chapo's run to freedom! Guzman, needless, to say, ain't no Andy Dufresne. He emerged clean as a whistle, laughing all the way to God knows where.
The daring escape surprised Enrique Peña Nieto—and most of his cabinet— as they were en route to France, for what was to be a glamorous state visit. The president didn't fly back, but Interior Minister Miguel Ángel Osorio Chong, the man Peña Nieto said he called "every day" to check up on "El Chapo," jumped on the first plane to Mexico City. A few hours after touchdown, he held a news conference in which he described, in painful detail, Guzman's meticulous dismantling of his captivity—and of the Mexican government's credibility. Still, Osorio said, he would not resign.
Osorio's fate now rests in the hands of Enrique Peña Nieto. Osorio's boss now has to decide what the word "unforgivable" really means to him.


FISSION/FUSION is an animated pixel art diptych honoring coyote fission-fusion adaptation in the face of persecution and eradication efforts, a resilience strategy that mirrors our very own human survival patterns.
FISSION/FUSION was part of the Hard G Project and was mounted near the Esmeralda slides in Bernal Hill in September 2018. It also appeared with the Hard G Project in the Art + Code showcase at XOXO 2018.
Many thanks to Dan Flores' book Coyote America, which explores, in addition to the unique adaptation techniques of the coyote, the environmental impacts and sociopolitical parallels of an animal that has survived and thrived beyond expectations, in the face of extreme hatred and extirpation measures.
One of the many functions of coyotes' howls is providing census data to coyote populations. When numbers appear low and fragmented, the coyote's biological response is to produce litters 2-3 times larger than usual.
Coyotes have the rare ability to function both in large packs and in solitary pairs, a skill that humans have also evolved. Harassment triggers coyotes to scatter and migrate widely across the landscape and recover their numbers in new and unfamiliar areas that they are able to rapidly adapt within.


text:
#pragma once
#ifndef SIELOBROWSER_ADDRESSBAR_HPP
#define SIELOBROWSER_ADDRESSBAR_HPP

#include "SharedDefines.hpp"

#include <QLineEdit>
#include <QTextLayout>
#include <QAction>

#include <QStringListModel>

#include <QStandardItemModel>
#include <QStyledItemDelegate>
#include <QTreeView>

#include <QHBoxLayout>

#include <QSize>

#include <QEvent>
#include <QContextMenuEvent>
#include <QShowEvent>
#include <QPaintEvent>
#include <QDropEvent>
#include <QResizeEvent>
#include <QFocusEvent>
#include <QKeyEvent>
#include <QMouseEvent>

#include "Widgets/LineEdit.hpp"

namespace Sn {
class TabbedWebView;
class LoadRequest;

class TabWidget;

class AddressBarCompleter;

class ToolButton;
class SiteIcon;

class SIELO_SHAREDLIB AddressBar: public LineEdit {
Q_OBJECT

public:
	AddressBar(TabWidget* tabWidget);

	TabbedWebView* webView() const { return m_webView; }
	void setWebView(TabbedWebView* view);

	TabWidget* tabWidget() const { return m_tabWidget; }
	void setTabWidget(TabWidget* tabWidget);

	static QString urlToText(const QUrl &url);

public slots:
	void setText(const QString& text);
	void showUrl(const QUrl& url);

private slots:
	void textEdited(const QString& text);
	void requestLoadUrl();
	void pasteAndGo();
	void reloadStopClicked();

	void updateSiteIcon();

	void setGoButtonVisible(bool state);

	void showCompletion(const QString &completion, bool completeDomain);
	void showDomainCompletion(const QString &completion);
	void clearCompletion();

	void loadStarted();
	void loadProgress(int progress);
	void loadFinished();

	void loadSettings();

private:
	void contextMenuEvent(QContextMenuEvent* event);
	void showEvent(QShowEvent* event);
	void focusInEvent(QFocusEvent* event);
	void focusOutEvent(QFocusEvent* event);
	void dropEvent(QDropEvent* event);
	void keyPressEvent(QKeyEvent* event);
	void mousePressEvent(QMouseEvent* event);

	LoadRequest createLoadRequest() const;
	void refreshTextFormat();

	bool processMainCommand(const QString& command, const QStringList& args);

	AddressBarCompleter* m_completer{nullptr};
	QStringListModel* m_domainCompleterModel{nullptr};

	SiteIcon* m_siteIcon{nullptr};
	ToolButton* m_reloadStopButton{nullptr};
	ToolButton* m_goButton{nullptr};

	TabWidget* m_tabWidget{nullptr};
	TabbedWebView* m_webView{nullptr};

	bool m_holdingAlt{false};
	int m_oldTextLength{0};
	int m_currentTextLength{0};
};

}

#endif //SIELOBROWSER_ADDRESSBAR_HPP

redpajama_set_name: RedPajamaGithub


text:
Saratoga County
Campaign raises $56k to preserve the Brookside Museum
by: Ben Mitchell
BALLSTON SPA, N.Y. (NEWS10) — On Wednesday, the Saratoga County History Center announced that its "Finish the Job!" campaign to preserve the Brookside Museum has raised $56,553. The funds will be used to replace 70-year-old storm windows, renovate the museum's storage areas and store, refinish floors, and enhance its energy efficiency.
"We are continually amazed by the generosity of our supporters," said Field Horne, history center president. "We went hat-in-hand to our friends and neighbors, asking them to help us save this awe-inspiring piece of local history, and they rallied and responded well beyond our expectations."
"Support for our 'Finish the Job!' campaign is the second capital campaign for the Saratoga County History Center," said Sean Kelleher, vice president of the history center. "The first campaign funded the restoration of the iconic porch; now we are doing energy efficiency and building restorations that will allow visitors to safely access the museum, grounds, and library for generations to come. It would not have been possible without support from the community."
Staff shakeup after Va. shooting by first-grader
Chesapeake Walmart shooting: 7 dead, 3 still in hospital
Woman found dead outside home, police investigating
Police attempting to ID driver who led brief chase


The crying "Anatoly Krasheninnikov" could have sunk due to the displacement of the cargo, which led to the tilting and tipping of the vessel. This was announced by the Minister of Special Programs and Cossack Affairs of the Kamchatka Territory Sergey Khabarov, reports TASS.
Khabarov added that at the moment the version with the shift of the load is the main one. "But finally everything will become clear when they interrogate the second mate," he said.
The vessel "Anatoly Krasheninnikov" sank in the waters of the Gulf of Kambalny of the Sea of Okhotsk on Friday, November 9. On board were 13 people, 10 of them were rescued by a nearby ship. The search for the captain and his two assistants. According to the Ministry of Emergency Situations, at the scene was observed the excitement of the sea up to 2.5 meters and the wind. The water temperature is about six degrees.
The wreck was registered in Petropavlovsk-Kamchatsky. At the time of the crash, it transported building materials and equipment to the village of Palana in the north of Kamchatka.


text:
package org.activiti.spring.test.jobexecutor;

import java.util.List;

import org.activiti.engine.ManagementService;
import org.activiti.engine.RuntimeService;
import org.activiti.engine.TaskService;
import org.activiti.engine.runtime.ProcessInstance;
import org.activiti.engine.task.Task;
import org.activiti.spring.impl.test.CleanTestExecutionListener;
import org.activiti.spring.impl.test.SpringActivitiTestCase;
import org.junit.Test;
import org.junit.runner.RunWith;
import org.springframework.beans.factory.annotation.Autowired;
import org.springframework.test.context.ContextConfiguration;
import org.springframework.test.context.TestExecutionListeners;
import org.springframework.test.context.junit4.SpringJUnit4ClassRunner;

/**
 * @author Pablo Ganga
 * @author Joram Barrez
 */
@RunWith(SpringJUnit4ClassRunner.class)
@TestExecutionListeners(CleanTestExecutionListener.class)
@ContextConfiguration("classpath:org/activiti/spring/test/components/SpringjobExecutorTest-context.xml")
public class SpringAsyncExecutorTest extends SpringActivitiTestCase {

  @Autowired
  protected ManagementService managementService;

  @Autowired
  protected RuntimeService runtimeService;

  @Autowired
  protected TaskService taskService;

  @Test
  public void testHappyJobExecutorPath() throws Exception {

    ProcessInstance instance = runtimeService.startProcessInstanceByKey("process1");
    assertNotNull(instance);
    waitForTasksToExpire();

    List<Task> activeTasks = taskService.createTaskQuery().processInstanceId(instance.getId()).list();
    assertTrue(activeTasks.isEmpty());
  }

  @Test
  public void testRollbackJobExecutorPath() throws Exception {

    ProcessInstance instance = runtimeService.startProcessInstanceByKey("errorProcess1");
    assertNotNull(instance);
    waitForTasksToExpire();

    List<Task> activeTasks = taskService.createTaskQuery().processInstanceId(instance.getId()).list();
    assertTrue(activeTasks.size() == 1);
  }

  private void waitForTasksToExpire() throws Exception {
    boolean finished = false;
    int nrOfSleeps = 0;
    while (!finished) {
      long jobCount = managementService.createJobQuery().count();
      long timerCount = managementService.createTimerJobQuery().count();
      if (jobCount == 0 && timerCount == 0) {
        finished = true;
      } else if (nrOfSleeps < 20){
        nrOfSleeps++;
        Thread.sleep(500L);
      } else {
        finished = true;
      }
    }
  }

}


text:
Castles /
Skipton /
Skipton Castle
Skipton Castle Castles
BD23 1AQ
Skipton Castle is one of the most complete and well preserved medieval castles in England. Fully roofed and with an enchanting early Tudor courtyard the stout towers of the gatehouse only hint at the splendour which is revealed as the visitor enters the castle grounds. Over 900 years old, Skipton Castle is one of the most complete and best preserved medieval castles in England and is well worth a visit at any season of the year.
The history of the castle is inseparable from that of the Clifford family who were granted the property by Edward II in 1310, when Robert Clifford was appointed first Lord Clifford of Skipton and Guardian of Craven, the wide tract of countryside to the north and west of Skipton.
Skipton Castle is open daily from 10am (Sunday 12 noon), except for 25 December. Last admission is at 6pm (October - February 4pm).
Adults: £5.20
Children (5-17): £2.70
Children under 5: free
Over 60s and students: £4.60
Family Ticket for two adults and up to 3 children over 5: £14.90 (saves up to £3.60).
VenueSkipton Castle
AddressSkipton, Skipton, Yorkshire, BD23 1AQ
Opening times10am - 6pm
Attraction typeCastles
Have you been to Skipton Castle? Please rate this attraction to assist others.
How many thumbs for Skipton Castle?


text:
Evaluation of the Hepa Wash®treatment in pigs with acute liver failure
Ahmed Al-Chalabi1,
Edouard Matevossian2,
Anne-K v Thaden3,
Peter Luppa4,
Albrecht Neiss5,
Tibor Schuster7,
Zejian Yang1,
Catherine Schreiber6,
Patrick Schimmel6,
Ewald Nairz6,
Aurel Perren8,9,
Peter Radermacher10,
Wolfgang Huber1,
Roland M Schmid1 &
Bernhard Kreymann1,6
Mortality of patients with acute liver failure (ALF) is still unacceptably high. Available liver support systems are still of limited success at improving survival. A new type of albumin dialysis, the Hepa Wash® system, was newly introduced. We evaluated the new liver support system as well as the Molecular Adsorbent Recycling System (MARS) in an ischemic porcine model of ALF.
In the first study animals were randomly allocated to control (n=5) and Hepa Wash (n=6) groups. In a further pilot study, two animals were treated with the MARS-system. All animals received the same medical and surgical procedures. An intraparenchymal intracranial pressure was inserted. Hemodynamic monitoring and goal-directed fluid therapy using the PiCCO system was done. Animals underwent functional end-to-side portacaval shunt and ligation of hepatic arteries. Treatment with albumin dialysis was started after fall of cerebral perfusion pressure to 45 mmHg and continued for 8 h.
All animals in the Hepa Wash group survived the 13-hour observation period, except for one that died after stopping treatment. Four of the control animals died within this period (p=0.03). Hepa Wash significantly reduced impairment of cerebral perfusion pressure (23±2 vs. 10±3 mmHg, p=0.006) and mean arterial pressure (37±1 vs. 24±2 mmHg, p=0.006) but had no effect on intracranial pressure (14±1 vs. 15±1 mmHg, p=0.72). Hepa Wash also enhanced cardiac index (4.94±0.32 vs. 3.36±0.25 l/min/m2, p=0.006) and renal function (urine production, 1850 ± 570 vs. 420 ± 180 ml, p=0.045) and eliminated water soluble (creatinine, 1.3±0.2 vs. 3.2±0.3 mg/dl, p=0.01; ammonia 562±124 vs. 1382±92 μg/dl, p=0.006) and protein-bound toxins (nitrate/nitrite 5.54±1.57 vs. 49.82±13.27 μmol/l, p=0.01). No adverse events that could be attributed to the Hepa Wash treatment were observed.
Hepa Wash was a safe procedure and improved multiorgan system failure in pigs with ALF. The survival benefit could be the result of ameliorating different organ functions in association with the detoxification capacity of water soluble and protein-bound toxins.
Since the introduction of renal replacement therapy, different methods of extracorporeal liver support therapies were tested. They appear to improve the survival of patients with acute liver failure but didn't have a major impact on survival of patients acute-on-chronic liver failure [1]. The mortality of liver failure remains unacceptably high and liver transplantation is still the only effective treatment. Albumin dialysis is one of the latest therapeutic approaches introduced. To date there are two types of albumin dialysis: Single Pass Albumin Dialysis (SPAD) and Molecular Adsorbent Recycling System (MARS®). The former has been described mainly in sporadic cases, where its use is limited by the costs of albumin and efficacy [2–6]. MARS has been used more widely and it has been shown to be effective in improving biochemical profile and hepatic encephalopathy as well as survival in specific patient groups [7–9]. A hard evidence of survival benefit of the MARS procedure is however still lacking, as the results of a large multicenter study have shown no improvement of mortality in patients with fulminant and subfulminant liver failure [10]. Different bioartificial liver support systems were used enthusiastically in small clinical trials [11–13] but in a multicenter study conducted by Demetrieu et al., they were found to improve the survival of patients with fulminant/subfulminant liver failure only after excluding primary nonfunction following liver transplantation which was included in the study group [14]. Finally, extracorporeal therapy with fractionated plasma Separation and Adsorption (Prometheus®) was associated with an improved survival in patients with acute liver failure, but mainly in retrospective and case report studies [15–17].
Animal models simulating acute liver failure (ALF) are not only needed to study the underlying poorly understood pathophysiological mechanisms but are also important for the evaluation of new liver support systems prior to introduction in clinical studies. Devascularizing ALF is one of the most common animal models used for evaluating liver support systems. Recently, our group developed such a model and tested its reproducibility [18].
In this work we present a preclinical study that evaluates the safety and efficacy of a new liver support system (Hepa Wash®, Figure 1), a type of albumin dialysis, in a large animal model of ischemic ALF. We also present the results of the MARS treatment in two pilot animals of the same model.
A schematic representation of Hepa Wash. The new liver support system is composed of three circuits: the blood, dialysate and Hepa Wash circuits.
Animals and housing
The preclinical study was approved by the ethical committee for animal studies in Bavaria, Germany. German landrace female pigs (~60 kg) were procured from the animal farm and were kept in the animal housing in the center for preclinical research in the hospital rechts der Isar for about 4–7 days to allow for accommodation. Animals were fasted approximately twelve hours before the operation but had free access to water. Housing and all medical and surgical procedures (Figure 2) were in accordance with the national animal protection act (Tierschutzgesetz) and the institution guidelines (registration number 55.2-1-54-2531-60-07, approved on 20.6.2007). Experiments were performed between January and April 2008. The Animals were divided randomly into two groups: the control (n=6) and the Hepa Wash (n=6) groups. One animal in control group was excluded due to insufficient induction of liver failure (which was histopathologically confirmed).
A timeline of the experiments.
In a small pilot study (n=2) that was conducted independently from the above randomized study, animals with acute liver failure were treated by the Molecular Adsorbent Recirculating System (MARS).
All animals in the Hepa Wash and the control groups and the two animals in the MARS pilot study were subjected to the same following surgical and medical procedures and all were treated under the same conditions e.g. noise.
Anesthesia and ventilation
Premedication of the animals was performed with ketamine (15 mg/kg), azaperone (2 mg/kg) and atropine (0.5-1 mg/kg) intramuscularly, respectively. Induction of anesthesia with propofol (60–100 mg, i.v.) was followed by intubation. Anesthesia was maintained intravenously with propofol (up to 8.5 mg/kg/h) fentanyl (up to 0.015 mg/kg/h), and atracurium (up to 0.7 mg/kg/h) depending on the depth of anesthesia. Animals were ventilated (Cicero EM, Dräger Medical Deutschland GmbH, Lübeck, Germany) with intermittent positive pressure and a mixture of oxygen and air (FiO2 30-60%). Mean airway pressure was aimed below 30 cmH2O and I:E ratio was adjusted to 1:2. The ventilation rate and tidal volume were set between 14–20 breaths per minute and 6–10 ml/kg, respectively, to ensure proper oxygenation.
Adequacy of anesthesia was assessed clinically by observing the animals ensuring that they have sufficient relaxation and analgesia. Spontaneous breathing must be absent.
Cannulation
Prior to induction of ALF, two jugular veins were cannulated to facilitate fluid and drug infusions. Blood arterial pressure was measured invasively using a cannula inserted into the carotid artery. A dialysis catheter (13F high flow two-lumen 20 cm, Achim Schulz-Lauterbach VMP, Iserlohn, Germany) was inserted so that the tip is in the right atrium of the heart. The femoral artery was catheterized with a 5-French thermistor-tipped catheter (PV 2015L20, Pulsion Medical Systems AG, Munich, Germany). A surgically inserted suprapubic bladder catheter was used to collect urine. An intracranial pressure transducer, Neurovent-P Temp (Raumedic AG, Helmbrechts, Germany) was inserted and positioned in the cerebral parenchyma.
Establishment of ALF
The surgical anatomy and procedures were described in more detail previously [18]. Laparotomy was performed and the structures in the hepatoduodenal ligament were exposed. The portal vein and inferior (caudal) vena cava were then partially clamped before a functional end-to-side portacaval shunt was established with polypropylene (prolene®, Ethicon Inc., Norderstedt, Germany). The development of splanchnic congestion was avoided by ensuring an adequate portal flow during partial clamping. All arteries supplying the liver and the hepatoduodenal ligament (except for bile duct which was left intact) were ligated (Vicryl® 2/0, Ethicon Inc., Norderstedt, Germany). Cefuroxime 500 mg was administered as an infusion during surgery.
Acid–base household and electrolytes
Sodium bicarbonate administration (8.4%) was administered to treat metabolic and respiratory acidosis if pH<7.3 or to increase bicarbonate levels (aim 28–30 mmol/l). Hyperkalemia was treated by insulin injections (5–25 IU) in boluses with simultaneous adjustment of glucose infusions. We used potassium-containing solutions or added KCl (20–80 ml, 1M) to the glucose infusions to correct hypokalemia. Hypocalcemia was treated by infusing calcium gluconate 10% 10-100ml/h.
Infusion of crystalloids (saline, glucose 5% or 20%) was directed according to measurements of the PiCCO system (Pulsion Medical Systems AG, Munich, Germany). Aim was to keep extravascular lung water index (ELWI)<12 ml/kg and global end-diastolic volume index (GEDI) between 500 and 800 ml/m2 as possible. The choice of crystalloids was dependent on the electrolyte balance, glucose level and acid–base balance. We targeted a mean blood glucose level of around 120 mg/dl [19].
Albumin dialysis
A laboratory prototype (Hepa Wash GmbH, München, Germany) was used to conduct the the Hepa Wash treatments. It is composed of three circuits: the blood, dialysate and Hepa Wash circuits (Figure 1). Approximately 40 grams of human serum albumin were used for each treatment. The composition of albumin dialysate in the hemodialyzers is similar to that of dialysate used in conventional hemodialysis (apart from containing 2% albumin). Postdilution 2l/h was performed with PrismaSol2® (Gambro Hospal GmbH, Gröbenzell, Germany). In the Hepa Wash circuit, albumin dialysate is divided into two parts. Each part undergoes a change of pH value by adding acid or base before passing through the filters resulting in a release of albumin-bound toxins. The unbound portion of toxins is removed by a filtration process. The acidified and the alkalinized albumin dialysates join each other so that a physiological pH (range 6.9-7.6) is generated before passage in the dialysate compartment of the hemodialyzers.
The treatment sessions in the two animals treated with MARS were performed independently by the Hepanet GmbH, Hannover, an established provider of the MARS therapy. The system was filled with 100g albumin.
Heparin was given to all animals (including the control group) by continuous infusion. Anticoagulation was monitored through the activated clotting time (ACT), which was measured by the Hemochron® (ITC, Edison, NJ). The ACT was kept between 150–250 seconds.
Both Hepa Wash and MARS were started as soon as the cerebral perfusion pressure dropped to 45 mmHg and were all continued for 8 hours.
Blood gas analysis was performed frequently to ensure optimal and quick adjustment of certain parameters e.g. glucose (Rapidpoint® 405, Siemens Health Care Diagnostics Inc., Eschborn, Germany). Blood samples were collected immediately before induction of ALF (T0) and every two hours thereafter. Samples for the measurement of nitrate/nitrite blood levels were frozen at -80°C and analyzed using the chemiluminescence method.
Euthanasia and autopsy
Surviving animals were sacrificed with a lethal dose of pentobarbitone and KCl injected intravenously 13 hours after induction of ALF. Animals were considered dead if cerebral perfusion pressure ≤ 5 mmHg for 5 minutes. All animals were examined for signs of bleeding during autopsy.
For comparing Hepa Wash with the control group, we used the cerebral perfusion pressure as the primary end point. The "ordered" hypotheses method was employed to avoid correction for the multiplicity of alpha error when multiple comparisons are performed [20]. If some of the data especially at the end of the experiments were missing due to death of the animal, then they were assumed to be equal to the latest measured value (the last value carried forward method). Data were expressed as mean ± SEM (standard error of the mean) - unless stated otherwise (as median and range) - after handling of the missing data. Comparisons were carried out as follows: The data were compared first from the latest time point i.e. eight hours after decrease of cerebral perfusion pressure to 45 mmHg. If the null hypothesis (no difference of cerebral perfusion pressure between the two groups) was rejected, an earlier adjacent time point was analyzed. Comparisons are repeated for the time points going backwards until the values are not significant anymore. Further statistical data, graphs and p-values for other parameters including the results of MARS treatments were displayed for explorative purposes only and not to be taken as confirmatory evidence.
Data were documented and analyzed using IBM SPSS 19.0 for Windows®. A non-parametric test (Mann–Whitney U) was used to compare the readings and biochemical values between groups, whereas the log-rank test was employed to statistically evaluate survival differences. A two-tailed p-value less than 0.05 was considered to indicate statistical significance.
Cerebral parameters
The cerebral perfusion pressure decreased to 45 mmHg after a median of 3¾ h (2-5 h) in the Hepa Wash group, and after a median of 3¼ h (2-4½ h) in the control group from induction of liver failure (p=0.46). The cerebral perfusion pressure was significantly higher after 8 hours of treatment in the Hepa Wash group in comparison with the control group (23 ± 2 vs. 10 ± 3 mmHg, respectively, p=0.006) (Figure 3). A significant difference was found as early as five hours after reduction of cerebral perfusion pressure to 45 mmHg (p=0.045). In contrast, the intracranial pressure did not change significantly after 8 hours of treatment with Hepa Wash (14 ± 1 vs. 15 ± 1 mmHg, respectively, p=0.72) (Table 1).
Hepa Wash significantly ameliorated cerebral perfusion pressure (CPP). * p<0.05 (difference between Hepa Wash and control); ** p=0.006 (difference between Hepa Wash and control); † Death of animals; SEM: standard error of mean.
Table 1 List of the main hemodynamic parameters of animals in the control and Hepa Wash groups
Four animals in the control group died during the observation period with a median of 10¾ h (9-13 h) (Figure 4). Five animals in the Hepa Wash group survived the 13-hour observation period. Only one animal died in the Hepa Wash group, and this occurred shortly after the end of the 8-hour-treatment period with Hepa Wash. The corresponding log-rank test showed a significant survival improvement in the Hepa Wash group (p=0.03).
A cumulative survival analysis showing an improvement of survival with the Hepa Wash procedure.
In contrast, the two animals in the MARS group survived for approximately 11½ and 12 h, respectively, after the induction of the liver failure. Deat h occurred after stopping treatment but also after a dramatic elevation of intracranial pressure shortly before end.
Animals in the Hepa Wash and control groups showed signs of fulminant hepatic failure with a rapid worsening of Quick value (prothrombin time) (39 ± 4 vs. 33 ± 5% at T 12, respectively, p=0.71) and INR (2.0 ± 0.1 vs. 2.7 ± 0.8 at T12, respectively, p=0.57). Fibrinogen also decreased rapidly (218 ± 18 vs. 233 ± 54 mg/dl at T12, respectively, p=0.71).
The mean arterial pressure in the Hepa Wash group was higher than in the control group (37 ± 1 vs. 24 ± 2 mmHg, respectively, p=0.006) after 8 hours of treatment (i.e. eight hours after cerebral perfusion pressure reached 45 mmHg) (Figure 3). The difference started to be significant after 4 hours of treatment (p=0.045) (Figure 3). The cardiac index was also higher in the Hepa Wash group at T12 (4.94 ± 0.33 vs. 3.36 ± 0.25, p=0.006). (Table 1). GEDI and ELWI were not significantly different between the two groups (Table 1). There was a positive fluid balance of around 230 ± 35 ml/h in the control group, whereas it was 320 ± 100 ml/h in the Hepa Wash group (p=0.46).
Urine output
Animals in the Hepa Wash group produced more urine (1850 ± 570 ml) than in the control group (420 ± 180 ml), collected after cerebral perfusion pressure decreased to 45 mmHg (p = 0.045).
Creatinine and blood urea nitrogen (BUN) were significantly lower in the Hepa Wash group than in the control group at T12 (1.3 ± 0.2 vs. 3.2 ± 0.3, p=0.01 and 5 ± 0 vs. 10 ± 1, p=0.006, respectively). Ammonia (Figure 5) was effectively removed from the blood of the animals in the Hepa Wash group (562 ± 124 vs. 1382 ± 92 μg/dl, at T12, p=0.006). Nitrate/nitrite levels were similarly lower in the Hepa Wash group (5.54 ± 1.57 vs. 49.82 ± 13.27 μmol/l at T12, p=0.01). Significant differences between the Hepa Wash and the control groups were found for blood pH and glucose (Table 2).
Elimination of ammonia by the Hepa Wash procedure. * p<0.05 (difference between Hepa Wash and control); † Death of animals; SEM: standard error of mean.
Table 2 List of the main biochemical and hematological parameters of animals in the control and Hepa Wash groups
Safety of Hepa Wash procedure
No significant differences were seen between the two groups for platelets or other coagulation parameters like antithrombin-III (Table 2). Despite anticoagulation with heparin in both groups no purpural skin lesions or internal hemorrhage was observed during autopsy.
This preclinical study evaluated a new type of albumin dialysis, the Hepa Wash procedure. The extracorporeal procedure was used for the first time in the treatment of pigs with ALF. The ischemic model used in this study was described in a previous work [18] and has a relatively large therapeutic window with less pronounced elevation of intracranial pressure in comparison with other surgical models used to evaluate other liver support systems, where the animals were smaller in size and the portal vein diversion was established by an end-to-side portacaval shunt [21–24]. Avoiding splanchnic congestion and severe hypotension during surgery by performing side-to-side portacaval shunt instead prevents the development of a multisystem organ failure at an earlier stage and produces only a moderate elevation of ammonia. Though cerebral edema is not a prominent feature of this ALF model, it still corresponds to the clinical situation in the majority of cases, where the overall incidence of clinical cerebral edema in association with ALF appears to be decreasing (less than 25%), while the incidence of multiple organ failure as a mode of death is increasing [25, 26].
Importantly, the ALF model used allows the evaluation of liver support systems, especially with the elevated levels of protein-bound and water-soluble toxins and the presence of multiple organ failure. We noticed many beneficial effects of the Hepa Wash in this model. Treatment enhanced cardiovascular stability and prevented the decline of cardiac index seen in the control group. This stabilization of cardiac index could be due to the removal of NO [27, 28], which may lead to disturbances of the myocardial contractility [29, 30].
The use of invasive measurement of the cardiovascular system (PiCCO System) helped us to eliminate difference in fluid balances as confounding factor. Early and continuous adjustment of GEDI and ELWI in both groups excludes volume depletion in the control group, where further elevation of GEDI by fluid infusions would worsen the already high ELWI values. Though they are part of the standard medical therapy [19], we did not use vasopressors in order to avoid the addition of a confounding factor, that may make the interpretation of the results more difficult.
The preserved urine production in the Hepa Wash group might additionally have contributed to the lower creatinine and BUN values, as these water soluble toxins were also effectively eliminated by Hepa Wash. A criticism to the design of the studies may emerge as the medical management of control animals did not comprise hemodialysis. Hyperkalemia was treated successfully with insulin-glucose therapy. No hypoglycemia was observed which could have been a confounding factor for the worse outcome in the control group. The metabolic acidosis was not severe enough to warrant hemodialysis. Oliguria in the ALF model was the only clinical condition which might have prompted the initiation of hemodialysis but then the mean arterial pressure was already very low to allow for treatment with extracorporeal procedures [31].
The improvement of the cerebral perfusion pressure in the treatment groups was mainly due to amelioration of the mean arterial pressure since the intracranial pressure in the ALF animal model did not show rapid and severe elevations. Therefore, cerebral perfusion pressure appears to be a better parameter to assess the treatment effects. These more pronounced effects on cerebral perfusion pressure are supported by elimination of ammonia by Hepa Wash. In the animal studies on MARS and Prometheus [21, 22], the intracranial pressure was significantly reduced, though no significant elimination of ammonia was found. The lower levels of intracranial pressure in our ALF model compared with the other models and the resultant difficulty in showing significant differences may explain the different results.
The treatment with Hepa Wash may have improved survival by supporting the detoxification function of the liver and the kidney, thereby interrupting the vicious cycle of elevated toxin level and the resultant worsening of multiple organ failure. Removal of liver disease-related toxins like ammonia, creatinine, bilirubin and vasodilators may reduce their toxic effects and improve the multiple organ failure. We did not use scoring systems like SOFA or MELD as they should be first validated in this animal model (which is of a short duration). The use of surrogate markers and mortality may obviate the use of scoring systems. Bilirubin elimination was not measured in the dialysate or filtrate, whereas the removed acid–base from blood is difficult to accurately quantify due to the nature of the procedure which involves adding strong acid and base to the dialysate. However, the improvement of plasma levels of these surrogate markers may support our assumption of the good detoxification capacity of the procedure.
The MARS system was able to improve the hemodynamic instability before the sudden and severe elevation of intracranial pressure has ensued. Why this elevation occurred only in the MARS animals and not in the Hepa Wash group is not clear but it may be related to the lower capacity of the procedure to remove ammonia and the resultant cerebral edema. In any case, the results are in line with the principle of limited available space and the normal exponential pressure-volume relationship of the cranium as described by Marmour et al. [32].
The authors believe that Hepa Wash could offer many advantages over other artificial liver support systems. In contrast to MARS or Prometheus where clearance of toxins significantly declines after the first two hours due to saturation of adsorbents or anion exchangers [33, 34], the Hepa Wash circuit has two conventional hemofilters which represent the site for eliminating the toxins. The albumin dialysate has an albumin concentration of 2% i.e. one tenth the concentration of albumin in the MARS procedure (20%). The efficient removal of toxins through passage in the Hepa Wash circuit allows the conduct of the dialysis procedure at higher flow rates than those used routinely in the MARS or the SPAD procedures. In the Hepa Wash procedure, the dialysate flow in the blood dialyzer can be increased to 60 l/h in comparison to 1 l/h in the SPAD procedure [5, 6]. Plasma levels of different medications including those that are protein bound may be affected in this relatively non-selective elimination procedure. Threrefore, close monitoring and substitution according to needs is required. Improved and consistent detoxification of both protein-bound and water soluble toxins were supported with safety aspects. The Hepa Wash procedure did not cause adverse events and did not result in bleeding despite the direct measurement of the intracranial pressure and the presence of several fresh surgical wounds like the laparotomy wound. The Hepa Wash, however, substitutes only some of the liver and kidney detoxification functions without replacement of synthetic functions which requires administration to the patient (e.g. coagulation factors).
The authors admit that these are only preclinical results with only a small sample size. We believe despite these limitations that the preliminary animal data of biochemical, organ function and survival improvement by the Hepa Wash are encouraging. Providing an adequate liver dialysis dose by increasing the capacity for the elimination of water-soluble and protein-bound toxins could enhance the efficacy of artificial liver systems and halt multisystem organ failure. Patients with ALF may show an improvement of mortality if they were treated early in the course of their illness with the new extracorporeal procedure. Clinical studies appear to be justified.
SPAD:
Single pass albumin dialysis
MARS:
Molecular adsorbent recirculating system
ALF:
Acute liver failure
GEDI:
Global enddiastolic volume index
ELWI:
Extravascular lung water index
ACT:
Activated clotting time
SVRI:
Systemic vascular resistance index.
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Malik R, Mookerjee RP, Jalan R: Infection and inflammation in liver failure: two sides of the same coin. J Hepatol. 2009, 51 (3): 426-429. 10.1016/j.jhep.2009.06.013.
Ellis A, Wendon J: Circulatory, respiratory, cerebral, and renal derangements in acute liver failure: pathophysiology and management. Seminars in liver disease. 1996, 16 (4): 379-388. 10.1055/s-2007-1007251.
Massion PB, Pelat M, Belge C, Balligand JL: Regulation of the mammalian heart function by nitric oxide. Comparative biochemistry and physiology. 2005, 142 (2): 144-150. 10.1016/j.cbpb.2005.05.048.
Umar S, van der Laarse A: Nitric oxide and nitric oxide synthase isoforms in the normal, hypertrophic, and failing heart. Mol Cell Biochem. 2010, 333 (1–2): 191-201.
Pestana D: Does renal replacement therapy increase mortality in the ICU?. Critical care (London, England). 2011, 15 (2): 415-10.1186/cc10071.
Marmarou A, Shulman K, LaMorgese J: Compartmental analysis of compliance and outflow resistance of the cerebrospinal fluid system. J Neurosurg. 1975, 43 (5): 523-534. 10.3171/jns.1975.43.5.0523.
Evenepoel P, Maes B, Wilmer A, Nevens F, Fevery J, Kuypers D, Bammens B, Vanrenterghem Y: Detoxifying capacity and kinetics of the molecular adsorbent recycling system. Contribution of the different inbuilt filters. Blood purification. 2003, 21 (3): 244-252.
Evenepoel P, Laleman W, Wilmer A, Claes K, Maes B, Kuypers D, Bammens B, Nevens F, Vanrenterghem Y: Detoxifying capacity and kinetics of prometheus–a new extracorporeal system for the treatment of liver failure. Blood purification. 2005, 23 (5): 349-358. 10.1159/000086885.
The authors gratefully acknowledge the financial support of the Bayerische Forschungsstiftung of the project "patal". We are deeply thankful to the personnel in the Center for Preclinical Research in Klinikum rechts der Isar for their support and cooperation.
This preclinical study was financially supported by the Bavarian Research Foundation (Bayerische Forschungsstiftung) and by the company Hepa Wash GmbH.
II Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, München, 81675, Germany
Ahmed Al-Chalabi, Zejian Yang, Wolfgang Huber, Roland M Schmid & Bernhard Kreymann
Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, München, Germany
Edouard Matevossian
Zentrum für Präklinische Forschung, Klinikum rechts der Isar, Technische Universität München, München, Germany
Anne-K v Thaden
Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, München, Germany
Peter Luppa
Clinrex GmbH, Munich, Muchen, Germany
Albrecht Neiss
Hepa Wash GmbH, Munich, Munchen, Germany
Catherine Schreiber, Patrick Schimmel, Ewald Nairz & Bernhard Kreymann
Institute of Medical Statistics and Epidemiology, Technische Universität München, Munchen, Germany
Tibor Schuster
Institute of Pathology, Universtiy of Bern, Bern, Switzerland
Aurel Perren
Institute of Pathology, Technical University Munich, Munchen, Germany
Sektion Anästhesiologische Pathophysiologie und Verfahrensentwicklung, Universitatsklinikum, Ulm, Germany
Peter Radermacher
Ahmed Al-Chalabi
Zejian Yang
Catherine Schreiber
Patrick Schimmel
Ewald Nairz
Roland M Schmid
Bernhard Kreymann
Correspondence to Ahmed Al-Chalabi.
Bernhard Kreymann is the Chief Executive Officer (CEO) of the company Hepa Wash GmbH and own stocks in the company. Ahmed Al-Chalabi own stocks/options in Hepa Wash GmbH (<1%). Catherine Schreiber, Patrick Schimmel and Ewald Nairz are employed by Hepa Wash GmbH and own stocks/options in the company (<1%). Other authors declare that they have no conflict of interests.
AA participated in the conception and design of the study, performed the surgical procedures, drafted the manuscript and performed the statistical analysis. EM performed the surgical procedures, helped to draft the manuscript. AT anesthetized, prepared and monitored animals and performed surgical procedures. PL arranged biochemical analysis of samples and revised manuscript. AP performed histopathological analysis. AN was involved in revising the manuscript especially the statistical analysis and the interpretation of results. TS participated and revised the statistical analysis and interpretation of data. CS, PS, EN and ZY prepared and operated the new liver support system. PR, WH and RMS revised and improved the manuscript. BK helped in drafting the manuscript and participated in the conception and design of the study as well as in the interpretation of data. All authors read and approved the final manuscript.
Al-Chalabi, A., Matevossian, E., v Thaden, AK. et al. Evaluation of the Hepa Wash®treatment in pigs with acute liver failure. BMC Gastroenterol 13, 83 (2013). https://doi.org/10.1186/1471-230X-13-83
Artificial liver
Multiple organ failure
Cardiovascular failure


In 1973, I transferred from Jacksonville to Chicago. At about the same time, three other guys transferred to San Juan—Warner (The Hummer) Armbruster, Bill Fagan, and Ron (can't remember his last name). Picture the passage of time characterized by the movie effect of calendar pages flipping over rapidly.
Two years later I was in High Altitude in Chicago when a new face appeared in the adjacent area (East High). We introduced each other—his name was Floyd Deaton, he'd started in Cleveland Center, but was just recently returned from San Juan. That piqued my interest and I immediately asked him if he knew the The Hummer, Bill, and Ron, and of course, he did. We spent the next several shifts sharing experiences common to those of us who had hired in around the same time and about people whom we both knew.
I learned his story—that he had gone to San Juan, the agreement for which usually was you got to pick where you wanted to return when your two year tour was completed. In Floyd's case, the FAA hosed him by saying, "no, you have Return Rights to the region from which you transferred." Good deal—that made his choices Cleveland (which he had gone to San Juan to get away from), Indianapolis, Chicago, or Minneapolis. A Hobson's Choice, Floyd elected for Chicago.
Floyd was an entertaining guy and told great stories. One of the best, and one that Roddy and I quote from on a regular basis involved Floyd, Bill, and Ron who had gone to Tampa for an R&R trip mid tour at San Juan. They had just gotten off their respective flights and had met up in a local pub to begin their pursuit of the local talent. The bar was a little dead and they struck up a conversation with the barmaid, who was a comely purveyor of spirits and good cheer.
They told their tales and spun their yarns and the barmaid gave as good as she got during the evening. About the time her shift was ending they had related how they were strangers in town, they only had a short time in town together, and as fun as she was, they were really each looking for something a little more intimate, if not long lasting.


text:
Rock West Composites Expands Into Binational Operations, Opening a Production Facility in Tijuana, Mexico
Rock West Composites announces the opening this month of a new Tijuana production facility, expanding production capacity for its rapidly growing business. While its US-based locations are growing and adding staff, the business's new binational operations strategy is targeting different types of contracts and creating opportunities to provide alternate pricing strategies for production work.
We see this as an opportunity to grow the entire business by maximizing the economic opportunities of this region.
SAN DIEGO (PRWEB) October 16, 2018
This month Rock West Composites announces the official opening of a new composites production facility in Tijuana, Baja California, Mexico. Due to rapid business growth, the company is simultaneously expanding its production capability at its US locations and across the border. While strategically moving into binational operations, the business is enabling globally competitive pricing for specific customer projects. The company expects to boost its significant year-over-year growth by winning new types of contracts that would have been out of reach previously.
The new Tijuana location will be doing production work using manufacturing processes including resin infusion, bladder molding, roll wrapping, wet layup, and precision composite assembly. The building also has an area for clean manufacturing requirements. Since the plant is only a short 30-minute drive from the San Diego headquarters, US-based customers will have a much easier time visiting this production facility, where their jobs are in process, rather than managing a product that is manufactured overseas.
US-based production projects and employment are also growing, as are the engineering, product development, and prototyping services that are performed at the San Diego and Salt Lake City locations. "This new operation will enable us to better service our customers by enabling more focused production in our US locations," James Gormican, CEO of Rock West Composites, said. "And the competitiveness of a binational operation will give us the ability to fulfill more diverse customer requirements, attracting programs that would have otherwise gone overseas."
Heading up the new location is Mr. Carlos Arganda. With twenty years of experience managing manufacturing facilities for binational operations, Mr. Arganda also has over a decade of experience in composites manufacturing. "We see this as an opportunity to grow the entire business by maximizing the economic opportunities of this region. San Diego and Tijuana have a history of supporting cross border business growth, recognizing that when our neighbors succeed, so do we."
For more information on Rock West Composites, visit https://www.rockwestcomposites.com.
About Rock West Composites
Rock West Composites provides composite products for variety of markets and customers. Specializing in carbon fiber composites, the business offers in-stock products, including tubes, plates and complementary materials, as well as custom products and services, such as product development, engineering services, prototyping, and manufacturing. Manufacturing methods include filament winding, roll wrap, resin infusion, bladder molding, and modified closed mold processes. Rock West Composites has facilities in San Diego, California, Salt Lake City, Utah, and Tijuana, Mexico. https://www.RockWestComposites.com
Julia Willis
Rock West Composites


text:
Campbell Brown's A.M. Future
NEXT:"Is This The Same FNC?"
PREVIOUS:Get Ready For Larry's 50th
By Brian on Nov. 2, 2006 - 4:15 PM
Following up on this speculation about Campbell Brown's future, perhaps at ABC or CBS:
"I think Campbell's best fit would be at CBS," an e-mailer says. "She could sub for Katie, or anchor '48 Hours' in addition to 'The Early Show.' Her youth, young marriage, potential to have children in the midst of her tenure, combined with the uncle/dad-like qualities of Harry Smith, the zaniness of Dave Price, and perhaps Julie Chen and/or Rene Syler as the newsreader might work. And I bet a bunch of affiliates that don't currently carry 'Early Show' in full would if Campbell were co-host."
> Update: 4:40pm: If she moves to CBS, she'll "continue to be in Katie's shadow," an e-mailer responds. "I think she wants her own identity…hence GMA and ABC News."
> Update: 4:44pm: "While I don't have any better ideas, CBS seems like a dead end for Campbell Brown," another person responds. "The network is lacking luster. She'd be a lively addition at GMA. Kate Snow is cute and sweet, but I have a hard time imagining her as the new Diane Sawyer. Brown, on the other hand, has the needed spunk and spirit, and I see her as an intellectual…"


It is a common place that nobody can expose exactly geometrical structure of the Sri Yantra performed through instruments: ruler, compass, 0.3 mm pencil etc. I don't name computer between the tools because it was not a primary implement for the geometrical art of yantra. Those illustrations modern readers can see in one book or another are only a feeble echo of possibly calculated solution and splendid view.
Thus we cannot go further in our preview of mathematical idea if we shall not name the main details have been lying in a base of Sri Yantra's construction.
Traditionally we begin to move from outside to the centre. The first sacred geometrical figure is Bhupura, or a square with four gates. It has double (usually) or triple line, colour or colourless. It can resemble a double svastika, if it will consist of eight prolonged bulges on four sides of the Bhupura.
The second principal figure is Mekhala, or triple concentrical circles (color or colorless) usually had been drawing without a compass. The area being defined between Bhupura and Mekhala has own name, the first from chakras: Traylokya-mohana chakra, or Enchantress of the Triple World. It is usually yellow on the whole, or one gate is white (down, East), another is blue (right, North), and two others are yellow (up and left, West and South). Inside and outside the first chakra there are many pictures of the gods, goddesses, and sacral animals on the original hand-painted Indian copies.
The next two following chakras are Sarva-saparipuraka and Sarva-sankshobhana. Very often researchers these lotus petals don't carry mathematical gist and can be any size, that is wrong point of view. Mathematical calculations cover the every line, circle, corner, every dot inside chakra. These two chakras consist of two rings of sixteen (first, outer, blue) lotus petals and eight (second, inner, red) lotus petals , indicating fulfilment of desire. Inner part of the petal also can carry images of recurring deities, Fig. 2 and 3.
The first chakra consisting of outer rim of 14 blue triangles on Fig. 3 (left) is Sarva-saubhagyadayaka chakra, or Giver of Auspiciousness, or Provider of All Prosperity. It is a 14-pointed star polygon from 6 interlocking big triangles with parallel bases inside the mandala.
The second chakra consisting of 10 red triangles (Fig. 3, right) is Sarvartha-sadhaka chakra, or Accomplisher of All Purpose, or Accomplisher of All Objects. It is a 10-pointed star polygon had been bearing by 6 primary big interlocking triangles.
The third yantra is Sarva-rakshakara chakra, or Giver of Protection, or Protector of All. There are two smaller triangles inside commencing six big triangles. It is again 10-pointed (inner) star polygon (Fig. 4, right, blue polygon).
The fourth yantra consisting of eight triangles is Sarva-rogahara chakra, or Remover of All Deceases, or Remover of All desires and Ills. This is an 8-pointed star polygon having up-down asymmetry (Fig.4, left, red polygon).
The fifth yantra is Sarva-siddhiprada chakra, or Giver of All Accomplishments, or Bestower of All Attainments. This is an inverted (usually colorless) triangle in the centre of Sri Yantra with the apex facing East (hanging downward when it is drawn on paper or cloth). It is a female principle symbolizing the creative generatrix of the cosmos, yoni-mandala (Fig. 4, left, a small red triangle).
The ninth and last chakra in the short preview of Sri Yantra composition is Sarva-anandamaya chakra, or Full of Bliss. This is a red dot Bindu in the centre of Sarva-siddhiprada chakra (Mula-trikona, primary triangle, female principle, colorless). Last chakra, the red dot, is a male principle symbolizing the static aspect of the cosmos, male seed of Being, the state of supreme joy (Fig. 4, right, a small red circle).
Fig. 4 Sarva-rakshakara chakra (right, blue polygon), Sarva-rogahara chakra (left, red polygon), Sarva-siddhiprada chakra (left, a small red triangle), and Sarva-anandamaya chakra (right, a small red circle).
It is a problem now that the key algorithm for this art and results of its implementation have been still undiscovered for public eyes by the time when the main requirements had been obviously formulated (1994-2011).
I would like to underline the fact that I don't consider computers' printouts as art of Sri Yantra, and I bother the less (men'she vsego?) about the zooming existing hand-drawn art works to find inner defects in composition. A trained programer or a mathematician with a special computer program aren't Sri Yantra masters. They just mathematicians and programers exactly in the quantity statistics of the USA or other countries can show in annual reports. It isn't a subject for discussion of present review at all.
The path of master is the master himself as he is. The master can get a virus and die. The Sri Yantra drawing can be lost or broken. The mathematical principle of Sri Yantra art is beautiful as is and absolutely unbroken by politicians, presidents, business visionaries, bankers, warlords, gangs, terrorists, religious fanatics, maniacs, and all sort of freaks.
It is not a Rig Veda level but after that relief we can definitely come up to discovery of algorithm directly.


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text:
Japan provides $7.7mn to support FMD control, reduce poverty in FATA
By APP
ISLAMABAD: The government of Japan would provide an amount of $2.7 million and $5 million respectively for Food and Agriculture Organisation (FAO) of the United Nations (UN) to implement two projects including the enhancement of Foot and Mouth Disease (FMD) control and the provision of livelihood in the Federally Administered Tribal Areas (FATA).
An agreement to this effect was signed between Ambassador of Japan to Pakistan Takashi Kurai and FAO Representative in Pakistan Minà Dowlatchahi.
Federal Minister for National Food Security and Research Sikandar Hayat Khan Bosan was also present at the signing ceremony. A grant agreement on the details of implementation of the project was signed and exchanged between Japan International Cooperation Agency (JICA) Chief Representative Yasuhiro Tojo and Minà Dowlatchahi at the same ceremony.
Foot and mouth is a highly contagious disease of cloven-footed animals that threaten food security and the livelihoods of smallholders and prevents livestock sector from achieving its economic potential. Due to this disease milk production may drop 50 to 70 per cent and mortality of young calves also decreases.
The project will significantly improve the FMD outbreaks surveillance and rapid response mechanism for disease control and reduce the incidence of FMD outbreaks in the country.
It will help curtail the losses caused by the disease and improve the productivity of livestock contributing to food security and improve the resilience of livestock farmers to threats of animal diseases.
In the second phase of the same project, the government of Japan through FAO will provide support to about 32,000 households in the targeted agencies of FATA, Kurram and Khyber.
The project will help reduce poverty and promote economic opportunities in the region through agriculture development which will support stabilisation and economic growth in the area.
This project is in line with the "FATA Sustainable Return and Rehabilitation Strategy", launched by FATA Secretariat and implemented in collaboration with UN agencies and donor countries including Japan.
Speaking on the occasion Federal Minister for National Food Security and Research Sikandar Hayat Khan Bosan said that government considers agriculture as a key area of focus to ensure food security for all segments of the society.
A growing agriculture sector not only plays a vital role in boosting the national economy but also reduces poverty and improves access to food. Improving nutrition diversification of agriculture by an enhanced focus on high-value horticulture, livestock and fisheries is the main thrust of the new 'Agriculture and Food Security Policy', he added.
Takashi Kurai said that agriculture sector is a vital component of Pakistan's economy and its steady growth is a prerequisite for the overall development of the country and these two projects will not only contribute to increased production of agricultural goods but also to the socio-economic development of Pakistan.
Spaking on the occasion Yasuhiro Tojo said that the project would make a significant contribution toward stabilisation of the area and essentially focus on value chain development to boost commercial agriculture in FATA.
Furthermore, the project will be expected to facilitate women participation in various interventions, particularly in homestead poultry, kitchen gardening and food and grain storage/preservation.
Thanking the government of Japan for its financial assistance, Minà Dowlatchahi said that these projects will cover important areas of interventions for the FATA Transition Plan. "They will contribute to the development of the agricultural sector in FATA region by improving food security, boosting economic activities and markets and as a result help achieve peace and security in the area."
The FMD project emphasises the importance of animal health as part of the One Health agenda, which is crucial for addressing food insecurity, improving nutrition and rural livelihoods that are dependent on livestock, she added.
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The brand new video for "Foolish Notions" is up on YouTube…Check it out!
We had a blast playing Michelle Clark's Sunset Sessions. K.D. Lang was masterful, I also thought Francis Dunnery was phenomenal as well. This guy is an amazing singer/songwriter whom I'd never heard of until Sunset, although he's been around forever. His song "Wounding and Healing"(:21) Francis Dunnery Live In Birmingham 4 had me quite choked up, seriously. Daniel Lanois' Black Dub killed it and quite frankly, EVERYONE was blown away..music supervisors, program directors and label people were all texting like fiends while they played..it was one of the best sets of music I've ever seen.Daniel Lanois\' Black Dub Check out "Ring the Alarm" on Youtube…I wouldn't post because I couldn't bear to include the ad that came before the video lol…one of the best sets! I'm incredibly grateful to be included among such richly talented people!.. Stevie Nicks was delightful to hear and to meet… and her new record sounds great!
It has been too long since I've blogged…it's been an incredible 7 months since Homo Luminous came out. Most of the planet hasn't heard it, but I'm working on it.
Welcome to Homo-Luminous.com! Have fun checking everything out and sharing it with your friends if you like it. We went into the studio this past January 15th and finished recording in May. The ensuing months have been spent creating this platform for the album. I'm extremely thankful to Jason Sikes for his tireless and brilliant work on both the website and the first video "Don't Panic", which can be easily shared on YouTube. The entire project has been an absolute labor of love for me…In truth, it's all about love and it's propagation…I hope you hear it and feel it in the music and see it in the sacred sites and archetypal images throughout. Enjoy…In munay, Chris.


Hi everyone and happy Friday! The weekend is upon us and more than a few of us will be visiting the pub for a tipple or two. Irish pubs are famed the world over for their atmosphere and hospitality. Did you know that there are over 7000 pubs in Ireland and around 10% of these are in Dublin city and county! So if you're visiting the city for the first time the choice of public houses can be somewhat overwhelming! Fear not-I've compliled my top 10! The following establishments all serve the perfect pint of Guinness so read on and Slainte!
Grogans is situated right beside Dublin's bustling Grafton street. No music, no TV-just conversation and undeniable atmosphere. The cheese and ham toasties are legendary and are the perfect accompaniment to a pint of Guinness. The walls are covered with works by local artists, all of which are for sale. If the weather is fine, grab a table outside and do some serious people watching. Little wonder this Dublin institution was a favorite of the poet, Patrick Kavanagh.
Next up we have Kehoes which dates back to 1803. The Victorian style decor survives since the late 19th century and is beautifully preserved. Feast your eyes on the stained glass mahogany doors and grab yourself a cosy snug to soak up the homely atmosphere. When it comes it Irish pubs, Kehoes ticks all the boxes!
Heading up to Baggot Street now to yet another Dublin institution. Toner's is one of Dublin's oldest and most traditional Irish Pubs. It is claimed that the snug is only place where W.B. Yeats would enjoy his occasional tipple. Winner of numerous awards including "Ireland's best traditional pub" in 2014.
Our next stop in Ireland's oldest pub! The Brazen Head dates all the way back to 1198. The sense of history here is palpable. Famous customers include Jonathan Swift, James Joyce and Michael Collins. The food here is fantastic with all the Irish traditional dishes on offer. The venue is also famed for it's live music and storytelling. An absolute must on any trip to Dublin.
So if you're on the tourist trail in Dublin, O'Neills is the perfect place to rest your weary feet as you explore the sights. Just a stone's throw away from the prestigious Trinity College, home to the book of Kells and right around the corner from the Molly Malone statue. Great for a spot of lunch and a quiet pint.
I just love this place! The beautifully preserved Victorian interior boasts a mirrored bar, beautifully carved mahogany fittings and twinkling chandeliers. Gorgeous Guinness and attentive bar staff make this one of my favorite Dublin pubs.
If you're looking for the famous Irish "craic" then O'Donoghue's is a must. A two minute walk from St. Stephen's Green, this place is always busy and the music is great. The legendary Christy Moore and The Dubliners have wowed the crowds at this very venue!
These two traditional Irish pubs are situated right next to one another and equally provide a great traditional Irish pub experience. A handy stop off if you're planning to visit the Guinness Storehouse or Phoenix Park.
So next up we have a Dublin bar which boasts a very famous customer! President Bill Clinton visited the bar in 1995 and his cousins are the proprietors. Cassidys is the former home of The Freeman's Journal, Ireland's oldest national newspaper.
The Stags Head dates back to 1770 and is arguably Dublin's finest example of a Victorian pub. Situated on the corner of a back street just off Dublin's busy Dame Street, people often stumble across this pub and end up staying longer than they intended! High ceilings, stained glass windows, mosaic floors and a red Connemara Marble-topped bar take you back to a bygone era. The food is good here too and checks out the entertainment in the Stag's Tail downstairs if you're in the mood to party!
Well that's all from me for this week. Have a great weekend!


text:
Q: Is there possible to fetch json.net object like this? I have this json file and i want to work with each object.

So foreach is on way but tried many of them even from stack and it doesn't fetch these objects to i.
Any ideas what went wrong?
I inspired by this thread
dynamic stuff = JsonConvert.DeserializeObject(File.ReadAllText(@"C:\Users\Paysami\Desktop\ccc\test.json"));
foreach (var i in stuff)
{
    //Console.WriteLine("{0} {1} {2} {3} {4} {5}\n", i.test1, i.test2, i.test3, i.test4, i.test5, i.test6);
    List<string> projectList = new List<string> { i.test1, i.test2, i.test3, i.test4, i.test5, i.test6 };
    foreach (var x in projectList)
    {
        Debug.WriteLine(x.ToString());
    }
}

A: Your json doesn't contain any array and you can't use foreach to read that.
You should first deserialize your json to a class and then use deserialized data.
public class Json
{
    public JsonObject Object1 { get; set; }

    public JsonObject Object2 { get; set; }

    public JsonObject Object3 { get; set; }
}

public class JsonObject
{
    public string Test1 { get; set; }
    public string Test2 { get; set; }
    public string Test3 { get; set; }
    public string Test4 { get; set; }
    public string Test5 { get; set; }
    public string Test6 { get; set; }
}

internal class Program
{
    private static void Main(string[] args)
    {
        var staff = JsonConvert.DeserializeObject<Json>(File.ReadAllText(@"jsonPath"));

        var jsonObjects = new List<JsonObject> { staff.Object1, staff.Object2, staff.Object3 };
        jsonObjects.ForEach(jsonObject => Console.WriteLine($"{jsonObject.Test1} {jsonObject.Test2}"));

        Console.ReadKey();
    }
}

A: You can also use First:
dynamic stuff = JsonConvert.DeserializeObject(File.ReadAllText(@"C:\.json"));
foreach (var i in stuff)
{
   List<string> projectList = new List<string> { (string)i.First.t1, (string)i.First.t2, (string)i.First.t3, (string)i.First.t4, (string)i.First.t5};
   foreach (var x in projectList)
   {
      Debug.WriteLine(x.ToString());
   }
}

A: Create a model/dto class with properties match with JSON and do the serialize/deserialize based on your request so that your data will be parsed correctly.

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