text:
Physician Associate/Assistant Impacts on Cancer Diagnosis in Primary Care: A Systematic Review
Jessica Sheringham, Angelos Kassianos, Ruth Plackett, Anwar Khan, and 2 more
https://doi.org/10.21203/rs.3.rs-142055/v1
posted 15 Jan, 2021
You are reading this latest preprint version
Background: Symptom recognition and timely referral in primary care are crucial for the early diagnosis of cancer. Physician assistants or associates (PAs) have been introduced in 15 healthcare systems across the world, with numbers increasing to address primary care physician shortages. Little is known about their impact on suspected cancer recognition and referral.
This review sought to summarise findings from international observational studies on PAs' competence and performance on processes concerned with the quality of recognition and referral of suspected cancer in primary care.
Method: A rapid systematic review of international peer-reviewed literature was performed (PROSPERO reference: CRD42019154114). Searches were undertaken on OVID, EMBASE, Web of Science, and CINAHL databases (2009-2019). Studies were eligible if they reported on PA skills, processes and outcomes relevant to suspected cancer recognition and referral. Title and abstract screening was followed by full paper review and data extraction. synthesis of qualitative and quantitative findings was undertaken on three themes: deployment, competence, and performance. Preliminary findings were discussed with an expert advisory group to inform interpretation.
Results: From 876 references, 15 eligible papers were identified, of which 13 were from the USA. Seven studies reported on general clinical processes in primary care that would support cancer diagnosis, most commonly ordering of diagnostic tests (n=6) and referrals to specialists (n=4). Fewer papers reported on consultation processes, such as examinations or history taking (n=3) Six papers considered PAs' competence and performance on cancer screening. PAs performed similarly to primary care physicians on rates of diagnostic tests ordered, referrals and patient outcomes (satisfaction, malpractice, emergency visits). No studies reported on the timeliness of cancer diagnosis.
Conclusion: This review of peer-reviewed literature combined with advisory group interpretation suggests the introduction of PAs into primary care may maintain the quality of referrals and diagnostic tests needed to support cancer diagnosis. It also highlights the lack of research on several aspects of PAs' roles, including outcomes of the diagnostic process.
Health Economics & Outcomes Research
early diagnosis of cancer
or general practice.
In health systems such as the UK, most patients with cancer first present to primary care.1 The role of primary care is twofold: first, to conduct investigations in primary care and second, to arrange referrals and tests conducted in secondary care.2 Research to date has focused on primary care physicians but primary care is changing, with greater input from a range of professionals, such as physician assistants (PAs).3–5
PAs have recently been introduced in the UK as physician associates. Training involves an intense 2-year Masters programme, which covers similar content to medicine (e.g. anatomy, physiology, pharmacology) and provides exposure to clinical environments, including primary care. Masters graduates that pass the national Faculty of Physician Associate exams are then permitted to work as PAs throughout the UK national health service (NHS). Their role is described as complementary to doctors and involves taking medical histories, managing and diagnosing illnesses.6(7) PAs in the UK are not currently regulated but following a consultation in 2019 there are plans to introduce it.7 Responsibilities should also expand when the regulatory framework in England aligns with that of other countries.8 This will enable them to perform other tasks central to cancer recognition and referral, e.g. ordering x-rays, for which they are trained but not allowed to do under current regulations. Numbers on PAs in England are expected to rise significantly following recent health service reforms4 which include funding for employment of 'additional roles' such as physician associates in newly established primary care networks from 2020/2021.9
PAs have been working in the USA (as physician assistants) for over 50 years, and 20–30% work in primary care.10 They have been introduced in several other countries11 Although PAs' roles vary both within and between health systems, there are opportunities to learn from international experience about the impact of PAs on the quality of cancer referral and recognition in primary care.
It is not clear whether the expansion of PA roles poses a threat or opportunity for the quality of cancer diagnostics in primary care. A systematic review of the international evidence on the role of PAs published in 2013 reported that the quality of evidence was weak with few studies comparing performance with other professionals.12 This review, however, was undertaken over seven years ago, and since, the volume of studies on PA performance has grown. There have been no systematic reviews examining the impact of PAs on cancer diagnosis.
This rapid review aimed to summarise findings from observational studies reporting on the PAs' performance and competence on processes to support recognition and referral of suspected cancer in primary care. Specifically, it sought to answer the following research questions:
Which tasks relevant to cancer diagnosis in primary care conducted by PAs have been examined in studies conducted in high income country settings?
To what extent do these studies indicate whether PAs have the knowledge and skills to support cancer diagnosis in primary care?
Informed by research question 1, how does PA performance compare with performance of other clinical professionals on processes (for example investigation, history taking, referral) and outcomes of care relevant to cancer diagnosis?
Through discussion with experts in primary care, cancer diagnosis and the physician associate profession, we sought to contextualise the findings to primary care in England.
The review was registered with PROSPERO (reference: CRD42019154114) and followed PRISMA guidelines.13 It sought to provide timely findings in order to inform the rollout of changes in primary care in England. Therefore, streamlined methods were used which sought to maximise robustness but provide timely findings. These steps included searching only peer reviewed literature in one language; limiting double screening; focusing only on key elements of quality appraisal tools for appraisal; and integrating a knowledge translation approach into the review.14
Searches for peer-reviewed papers were undertaken on the following databases: OVID, EMBASE, Web of Science, and CINAHL. The search was conducted in November 2019 with database alerts set up to identify relevant literature published since that date. The search strategy was adapted from Skrobanski et al to include terms related to PAs' potential role in the diagnostic process, informed by the NHS description of typical PA tasks in England (i.e. taking medical histories from patients, performing physical examinations, diagnosing illnesses, performing diagnostic procedures, analysing test results) plus additional duties that PAs may be permitted to undertake once regulation is in place such as ordering x-rays.6 15 (Supplementary data) Searching was limited to publications in English since 2009. While physician associates were first introduced in England before 2009, this later date was selected because access to diagnostic tools has changed considerably over the last ten years.
Additional eligible studies were sought by hand-searching reference lists of included studies, consultation with experts and screening of citation alerts since searches were carried out.
Inclusion criteria – piloted by two researchers on a sample of abstracts – are described in Table 1.
Review eligibility criteria, highlighting changes made following piloting
Physician associates (PAs) or assistants working in primary care in any high-income country.
CHANGE: The search terms initially included a range of terms for primary care settings. When articles were retrieved, several potentially relevant ones were missing. The search was amended to remove primary care terms. Instead a paper's relevance to primary care in the UK was assessed on all retrieved records, where possible at abstract screening or otherwise at full text review.
Intervention/ Exposure:
Actions taken by PAs for patients with any symptom(s) that might be cancer
CHANGE: Although initially planned, the search was not limited to papers with mention of possible cancer symptoms. In practice almost any symptom may be a sign of cancer so it was not feasible to turn this criterion into specific search terms. However, it was possible to exclude papers on abstract screening or full-text review where the symptom or aims of the study was clearly not relevant to cancer diagnosis, e.g. screening for domestic violence, care for multimorbidity.
Comparator:
Any other clinical professional
CHANGE: Following the advice of an expert advisor we included studies where PA data were aggregated with nurse practitioners but excluded studies were PA data were aggregated with other professionals. This was in recognition of the fact that, in many settings, nurse practitioner and PA roles may overlap.
Quality of symptom recognition and referral where cancer might be suspected
This comprised PA skills, confidence, performance, deployment (activities or decisions undertaken to reach a diagnosis, such as history taking, symptom recognition, referral or investigation, triage and cancer screening referral), satisfaction with care, and adherence to guidance/best practice.
Excluded: Chronic disease management, non-cancer screening or primary prevention.
Peer-reviewed papers
Study design: Primary research - qualitative or quantitative
- Editorials, letters or narrative reviews
- Systematic reviews though these were first searched for eligible references.
All identified studies underwent title/abstract and full-text screening. For title and abstract screening, a researcher independently reviewed abstracts of all studies against the inclusion criteria described above. All studies identified for inclusion underwent full-text screening. To expedite the review process, multiple reviewers split the screening between them and double screened a proportion (≥ 10%). Discrepancies were resolved by discussion between both reviewers and the PI.
Data extraction and quality appraisal
Data extraction and quality appraisal were undertaken concurrently and split across three reviewers with a proportion (10%) dual-extracted by a fourth researcher for quality assurance. A data extraction form was first piloted then used by four reviewers to extract data on during full text screening on the research question/purpose, study design, setting (clinical and geographical), sample size, sample characteristics, outcomes measured, analysis methods, results and authors' conclusions. Appraisal focused on selected measures of methodological quality and relevance. For methodological quality, researchers considered risk of selection bias based on study descriptions of sampling strategy and response rates; and measurement bias from risks of social desirability or unvalidated measures. Studies with a high risk of bias were still described qualitatively but excluded from synthesis of quantitative results. For relevance, studies were appraised in terms of relevance to (a) UK primary care and (b) cancer diagnosis.
Included studies were narratively synthesised into themes guided by the research questions:
PA deployment on tasks to support cancer diagnosis reported in the literature
PA competence and skills
PA performance
Quantitative and qualitative data were combined in the narrative synthesis. Quantitative findings for key outcomes were summarised from studies which compared PA with primary care physician performance and risk of bias was not high.
Consultation and knowledge translation
An expert advisory group was convened for the project: comprising physician associates with experience of working in the UK, GPs, medical educators with PA education programmes and researchers in early diagnosis of cancer. Consultation took place with the group, firstly to identify and include any relevant literature that had not emerged from the database search, and secondly to contribute towards the interpretation and policy and research implications of the results. Themes discussed with the group focused on barriers or opportunities to maximising the contribution of PAs in England and to surface other important perceptions of PA performance and competence not identified in the literature.
Description of included papers
The search retrieved 873 unique records, plus three through citation alerts, of which 49 papers were included for full paper review. After excluding those not meeting inclusion criteria, 14 studies from 15 papers remained in the dataset, of which thirteen were from the USA (Fig. 1). Six of the US-based studies were national. All the other studies were state-wide or regional. Ten studies pertained to primary care settings and five included both primary and secondary care. (Table 2)
Description of included studies
Study objective
Sitesa)
Design (data collection)
Task or outcome
Risk of biasb)
1. Blaes et al, 2019
Determine primary care providers' screening practices for women at high risk of breast cancer, & examine differences in practices and knowledge of recommendations across providers
Cross-sectional (survey)
2. Boone et al, 2016
Understand what may limit adherence to new screening policies
3. Brock et al, 2017
Compare rates of malpractice reports and adverse actions for physicians, physician assistants (PAs), and nurse practitioners (NPs).
Secondary & primary care
Longitudinal (claims)
Diagnosis (delay or failure to diagnose)
4. Burrows et al, 2020
Explore PA role integration in the Ontario healthcare system through an in-depth analysis of setting and role descriptions, described outcomes, and healthcare provider perceptions
Case study (interviews, documentary analysis)
Referrals to other physicians
5. Drennan et al 2015
Compare outcomes and costs of same-day requested consultations by PAs with those of GPs
South, East, & South West
Longitudinal (medical records)
6. Feeley et al, 2009
Explore how colorectal cancer screening is approached in primary care.
Qualitative (focus groups)
7. Hughes et al, 2015
Compare use of diagnostic tests by NPs and PAs and PCPs
8. Johnson et al, 2019
Determine whether Advanced Practice Providers (APPs) provided the same quality care as physicians in a variety of settings
Quasi-experimental (online vignettes)
History taking, physical examination, diagnostic tests ordered, making a diagnosis
9. Kepka D et al 2014
Evaluate the relationship between type of medical provider seen in the past 12 months and receipt of cancer screening
Medium /low
10. Kurtzman et al, 2017
Compare the quality of care and practice patterns of NPs, PAs, and primary care physicians in health centres.
Longitudinal (repeated cross- sectional surveys)
Reconsultation
11. Laird et al, 2020
1) describe and compare Texas NP & PA knowledge and use of screening guidelines for colorectal cancer (2) compare recommendations for referral for genetic counselling for colorectal or endometrial cancer
12. Liu et al 2017
What impact NPs and PAs have on utilization in a setting where physician-supervised NPs and PAs provide face-to-face primary care
Quasi-experimental (medical records)
Diagnostic tests ordered
ED visits
13. Mafi et al, 2016
Compare APCs and physicians in providing inefficient or low-value care [radiography (for URIs and back pain), computed tomography or magnetic resonance imaging (for headache and back pain), and referrals to other physicians]
14. Martin et al 2019
Compare health care providers' breast cancer screening practices for average-risk women at the ages of 40–44 and 45–49 years and
15. Tang et al 2016
Clinician factors are associated with prostate-specific antigen (PSA) screening in older veterans with limited life expectancy
Cross-sectional (medical records)
Low/medium
a) Sites: n/a stated where data were collected from individual providers and analysis was not available or applicable at site level.
b) High, medium or low. Detailed assessment of bias and other considerations of quality and relevance are given in Supplementary data.
Study design & source of data
Thirteen studies were quantitative comprising cross-sectional (n = 6, surveys or medical records studies) and longitudinal designs (n = 7, repeated cross-sectional surveys, quasi-experimental studies and medical record cohort studies). Three studies used data from national surveys of professionals (the National Ambulatory Medical Care Survey and the National Hospital Ambulatory Medical Care Survey (NHAMCS))16 17 or patients (the National Health Interview Survey (NHIS) with Cancer Control Supplement data on screening and HPV vaccination).18 Bespoke surveys were developed by adapting existing surveys, or creating new instruments, including clinical vignettes, where there was little detail about survey construction or instrument validation. 19 20Records were obtained from national US health care records systems - Veteran Affairs,21 MediCare fee-for-service claims22, National Practitioner Data Bank claims.23. In two studies regional or state-wide records data were used from Kaiser Permanente's electronic medical records in Georgia24 and, patient records held by local, general practice systems in England.25 There were two qualitative studies, one of which collected data via focus groups, the other used case studies and collected data through interviews and document analysis.
All studies included consideration of PAs' competence and performance in relation to other primary care professionals, most commonly primary care physicians. The definition of primary care physicians varied. In the USA, primary care physicians included general practice, family practice, and internal medicine,22 and general practice, family medicine, internal medicine, and/or obstetrics/ gynaecology.18, whilst in England, primary care physicians were general practitioners only.25 In five studies, PA and advanced nurse practitioner (NP) data were aggregated in the paper's main analysis. 16 18 22 24 26 In two studies disaggregated data were available in supplementary data or secondary analyses. 16 22
Sample sizes in surveys were between 5020 27 and 489118 with response rates ranging from 7.7%20 27 to over 80%.17 In studies using medical records the smallest sample was 2086.25 In the largest study there were over 800,000 patient records but only 7% of patients received care from PAs.21 Of the qualitative studies, Feeley et al conducted focus groups with physicians (n = 56), NP/PAs (n = 47), and patients (n = 103) on colorectal screening.26 Burrows obtained interview data from 24 PAs, and those that worked with them (17 physicians, 2 medical residents, 2 registered nurses, and 1 family health team administrator) but there was no information on the documentary sources they used.28
Quality and risk of bias
Four quantitative studies had a high risk of bias due to low, unreported or biased response rates. In another quantitative study it was not possible to disaggregate NP from PA performance. These studies were excluded from the quantitative summary of study findings. Further reporting of bias and other quality/relevance concerns limiting the applicability of the study findings to this review are in the Appendix. We also consider the variable relevance of studies to the context of UK primary care in 2020 in Box 1 and the discussion.
1. PA deployment on tasks to support cancer diagnosis
Seven studies reported on general clinical processes in primary care that would support cancer diagnosis. (Table 2) Most commonly, studies reported on ordering of diagnostic tests (n = 6).16 17 19 22 24 25 Four studies considered referral to other physicians.16 17 24 28 Two studies reported on physical examinations. 19 17 Only Johnson et al reported on history taking.19 Two studies explicitly linked care delivery with quality, by examining ordering of guideline-discordant tests or unnecessary referrals 16 or by scoring performance on clinical vignettes.19 Seven studies reported on tasks related to cancer screening, specifically breast, (n = 3)18 20 27, colorectal (n = 3) 29,26 18) cervical (n = 2) 30 18, prostate (n = 1),21 and endometrial cancer (n = 1).29 (Table 2)
2. PA competence and skills
Four studies across three surveys examined practitioners' knowledge, opinions and understanding of national guideline recommendations on cancer screening.20 27 30 These studies found that, in common with nurse practitioners, PAs were more likely to recommend breast screening than physicians and both PAs and NPs had knowledge gaps on risk-stratified screening and referral for genetic counselling in adults at increased risk for colorectal cancer. All these studies, however, had a high risk of bias due to very low response rates.
In Johnson et al's study of performance on history taking, examinations and diagnostic workup, clinicians' responses to two clinical vignettes were scored according to their alignment with national evidence-based and system-specific recommendations. While no overall difference in PA/NP and physician performance was found, there was a lack of detail on the vignette construction and validation and it was not possible to disaggregate NP and PA performance.19
Burrows et al's qualitative study in Ontario compared physicians' perceptions of with PAs' XX in family medicine with perceptions from inpatient, outpatient and emergency settings.28. It found experienced PAs were often valued as experts, for example: "other consulting services [such as specialist diagnostics] …started to prefer getting consults from the PA because of the PA's understanding of the precise information that the consulting service requires".28
3. PA performance as measured by processes and patient outcomes
Table 3 summarises quantitative findings in studies with medium or low risk of bias that compared processes and outcomes of care between PAs and primary care physicians. There were no reported differences between PAs and primary care physicians in diagnostic test ordering (3/4 analyses), referrals (3/3 analyses) or screening practices (1/1 analysis). Where differences in care processes were found (1/8 analyses), it was not possible to conclude these differences indicated better or worse quality of care. While PAs had similar rates of guideline-discordant care (PSA screening rates for older veterans with limited life expectancy) to physicians, all practitioners had higher rates than physician trainees.21
Findings from studies comparing PA performance with primary care physicians
Study: analysis
Main finding: PA performance vs primary care physicians
Patient cohort seen by PAs vs primary care physicians
Covariates included in adjusted analyses
Drennan et al, 2015 25: Diagnostic tests (no specific ones specified)
↔ No significant difference
Rate ratio 1.08 (0.89–1.30)
- Younger
- From different geographical areas
- Healthier/lower healthcare use
Age, acuity of presenting problem, sex, practice attendances in the previous 3 months, no. problems, chronic disease registers, socioeconomic deprivation
Hughes et al, 2015 22: Imaging
↑ Higher use
Adjusted OR 1.34 (1.27–1.42) a)
- higher % female
- higher % of white ethnicity
- Healthier
Patient age group, sex, race, state, urban, comorbidity.
Kurtzman et al, 2017 17: Imaging
Adjusted OR 1.14 (0.84–1.54)
Similar (age, gender, ethnicity, payer source) to PCPs.
Age, sex, race, ethnicity, payer, metro status, region, reason for visit, health centre type, education, year.
Mafi et al, 2016 16
- Radiography (in 'low value' cases) b)
10.2 in PCP vs 11.4 in PAs (alone), p = 0.71 and 9.5% in PAs (shared) p = 0.75
Patient age, sex, race or ethnicity, comorbidity, symptom acuity, insurance status, urban location, geographic region, year
- CT or MRI (in 'low value' cases)
6.0 in PCP vs 9.9 in PAs (alone), p = 0.3 and 6.8% in PAs (shared) p = 0.69
Drennan et al., 2015: 25
Rate ratio 0.95 9(0.63–1.43) p = 0.80
Age, acuity of presenting problem, sex, # practice attendances in the previous 3 months, # problems, # chronic disease registers, socioeconomic deprivation
Kurtzman et al, 2017 17
PAs saw similar patient profile (age, gender, ethnicity, payer source) to PCPs.
Mafi et al, 2016 16: Situations in which referral considered to be low value
8.2 in PCP vs 5.9 in PAs (alone), p = 0.52 and 8.6% in PAs (shared) p = 0.86
Patient age, sex, race or ethnicity, comorbidity, symptom acuity, insurance status, urban location, geographic region, and year
Tang et al, 2016 21: PSA screening rates for patients with limited life expectancy
↔ No significant difference c)
Screening offered in 41.3% of cases by PAs vs 41.5% by PCPs
Patient age, race, marital status, income, education, clinician clustering
Brock et al, 2017 23: Malpractice reports per 1,000 clinicians d): diagnosis related claims comprise diagnosis failure or delay in diagnosis
↓ Lower payments
Physician median payments ranged from 1.3 to 2.3 times higher than PAs or NPs
No data but differences in breadth of patient acuity proposed as possible explanation for findings.
Drennan et al., 201525:
- Re-consultation within 14 days for the same or a linked problem
- Patient Satisfaction e)
Adjusted rate ratio 1.24 (0.86–1.79), p = 0.25
↔ No significant difference e)
Kurtzman et al, 2017 17: Re-consultation
Adjusted odds ratio 0.77(.52-1.13)
Age, sex, race, ethnicity, payer, metro status, region, reason for visit, health center type, education, year.
a) Hughes:. In the main analysis, nurse practitioner and PA data were aggregated as APC. In sensitivity analyses: NPs ordered less imaging than PAs (OR, 0.59 [0.53-0.66]); APCs ordered less imaging than PCPs for acute respiratory tract infection (OR, 0.68 [0.51-0.90]); Differences were greater for radiography than non-radiography imaging
b) Mafi: Findings were presented for both hospital and office based primary care settings. 89.9% of the data reflected visits to clinicians in office-based physician practices (data from the NAMC), so these figures are presented. Disaggregated data from supplementary data are presented here. Alone reflects visits to PAs where they saw the patient without a physician; shared reflects consultations where a physician was alongside.
c) Tang: Men whose clinician was a physician trainee had substantially lower PSA screening rates than those with an attending physician, nurse practitioner, or physician assistant
d) Brock: Diagnosis malpractice claims, while higher for physicians, comprise a greater proportion of PA than physician claims (53% vs 32%). This result may be partially explained by the presence of surgeons and anaesthesiologists in the physician group, or it may signal where PAs and NPs might be most at risk for error.
e) Drennan: other findings comprised: consultation duration was longer for PAs than GPs but costs per consultation were lower.
Three studies reported patient outcomes. These comprised re-consultation rates in primary care,17 25, satisfaction and malpractice claims,23 with a brief breakdown of claims due to diagnostic failure or delays in diagnosis,23 but no studies reported on the timeliness of cancer diagnosis (e.g. stage, survival). There were no reported differences in general patient outcomes (satisfaction, re-consultation rates). While PAs had fewer malpractice payments than physicians, a greater proportion were related to diagnosis. As noted by the authors, it may signal that PAs might be at greater risk of diagnostic error but could also be explained by the presence in the physician group of surgeons and anaesthesiologists -who had malpractice claims related to surgical outcomes.23
Where it was reported, the profile of patients seen by PAs differed from that seen by primary care physicians in all but one study.
BOX 1. Applicability of review findings to current UK context
Preliminary review findings were presented remotely to the advisory group with comparisons between UK and US contexts (table) to stimulate discussion.
Introduced in 1960s.
Introduced 2003. 1st UK graduates in 2007.31
# of PAs in primary care
Approx: 60,000.11 12
In England: 359 (March 2020), up from 25 in 2015.32
Regulation & powers
• Subject to statutory regulation
• Can prescribe & order ionising radiation.
• Regulation planned, not yet in place7
• Not yet licensed to prescribe or order ionising radiation.
Healthcare system context
• Variable spend within & between states5
• 76% of Americans have access
• Co-payment & costs increasing33
Professionals: two models
• Physicians only (family medicine, general internal medicine, general paediatrics)
• Multidisciplinary team of nurses, nurse practitioners, PAs, OB/GYNs, psychiatrists, psychologists, and social workers.
• Spend determined nationally
• Access almost universal
• Free at point of delivery
• Until 2020: typically comprised general practitioners, practice nurses.
• From 2020 in England: primary care networks include district nurses, PAs, physiotherapists, pharmacists, social prescribers, paramedics, podiatrists, geriatricians, social care & voluntary sector.34
• Acute and growing shortage of primary care physicians common to both.
Roles in cancer recognition & care
• Advice on screening eligibility, organising referrals for and delivering screening tests.
• Guidance varies at national, professional and state levels.20
• Screening lies outside of primary care except for delivery of cervical screening.
• National guidance for suspected cancer referrals.35
• Similar skills/knowledge: cancer risks, 'red-flag' symptoms, physical examinations.
• Similar pre-qualifying training: ~2 years intensive core curriculum + national exam.36
Themes from advisory group discussion to support interpretation of findings comprised:
Implications of 'new' workforce:
- PAs in the UK are a young profession. Most PAs entering primary care have little prior clinical experience so will need intensive support. However, freshly graduated, young PAs are often very ready to learn.
- Many new graduates – not just PAs - feel unprepared for General Practice and initially need close clinical supervision. The 'learning curve' in competence may be observed for other professions too.
- Lack of regulation is recognised as a significant barrier to recruiting PAs into primary care. Lack of prescribing rights noted as a particular barrier.
- Some PAs experienced few barriers to their own practice but noted attitudinal barriers from other staff.
- Regulation may influence standing with doctors & open discussion about prescribing rights.
Other US/UK contextual differences:
- The US healthcare system is fragmented between and within states and providers. Variation in PA performance in the UK, therefore may be less variable than in the USA.
- US patients have greater power to 'shop around' than in the UK which affects the clinician-patient power dynamic. Also, patients' perceptions of PAs may be different to GPs which may also result in a different dynamic of PA-patient consultations. This is unexplored in the review.
This review of peer-reviewed literature combined with advisory group interpretation suggests the introduction of PAs into primary care may maintain the quality of referrals and diagnostic tests needed to support cancer diagnosis. It also highlights the lack of research on several aspects of PAs' roles, including outcomes of the diagnostic process.
This review, the first of its kind to focus on cancer diagnosis, provides timely insights into the contribution of PAs in an important sphere of activity at a time of rapid expansion of the physician associate profession in England. It also addresses some of the limitations of the last major systematic review in 2013 examining the contribution of PAs to primary care, which reported the quality of evidence was weak with few studies comparing performance with other professionals.12 There are important limitations, however.
Most (13/15) studies came from USA, which limit the transferability of findings to other healthcare systems. In particular, in the US the role of primary care professionals in cancer diagnosis may be different; they are not always required for referral to specialists but they are often central in organising cancer screening (a task led by cancer screening hubs in England). Studies undertaken in other countries (Netherlands, Israel, Germany) were identified but excluded because PAs were not deployed in primary care settings. However, eligible studies from the UK and Canada – where access to specialist care is normally via a family physician37 - provided corroborative and complementary insights to those from USA. Moreover, US-based studies have relevance internationally for two other key reasons. Firstly, the drivers for the introduction of PAs have been experienced globally, i.e. shortages in primary care providers amid increasing patient demand, and shifts to multidisciplinary models of primary care teams to provide care.3 Secondly, they give some indications of how PAs that are regulated and integrated into the healthcare system might perform on processes such as ordering of ionizing radiation that are not currently permitted in the UK.
None of the studies sought specifically to investigate the impact of PAs on cancer diagnosis. Some excluded cases with 'red flag' symptoms which might exclude cases where cancer was suspected. However, red-flag symptoms are present in only a minority of cancer diagnoses, and UK guidance specifically recommends investigation of a wide range of symptoms.35 Five studies presented only aggregated data for NPs and PAs. Numbers of PAs may be smaller than NPs, so there is a risk that findings are driven by NPs rather than PAs. This aggregation, therefore, may miss important differences in care. Where sub-analyses had disaggregated data, PAs data was often more similar to primary care physicians than NPs. To inform workforce decisions, in future studies PA and NP performance needs to be reported separately.
Most studies considered PAs' impact from the perspective of other clinical professionals only; views of patients and non-clinical practice staff were absent from 12/15 studies. As others have reported, patients are open to seeing PAs and experience with them is largely positive when the role is explained.3839 Studies so far have focused on preferences and degree of satisfaction with PAs. As Box 1 comments indicate, given the potential difference in status and duration of training, patients may develop a different relationship, and communicate in different ways with PAs than with primary care physicians.
The streamlining of review methods did result in findings within a relatively short period of time that could be shared to influence practice (e.g. with preceptorship scheme in North London). Streamlining review methods may have resulted in missing relevant papers, particularly due to narrowness of the search (restricted to English paper and since 2009). However, a systematic review conducted in 2013, identified major gaps in the literature at this point so extending the search to find papers published earlier than 2009 would be unlikely to yield further insights.
Our principal finding – that in most studies PAs performed similarly to physicians – is largely in line with findings from other studies.12 In the UK a suite of studies examining the impact of PAs in primary care at micro, meso and macro levels in 2014 reported PAs were acceptable, effective and efficient in complementing the work of GPs.32 25 40 At this time, however, there were just 25 PAs working in primary care, with around half trained outside of the UK, which may limit the transferability of this study to a context where most PAs have been trained in the UK and their presence is the norm, not the exception. As others have noted, this finding does not mean that PAs and physicians deliver equivalent care in general. Indeed, in common with other studies, the profile of patients seen by PAs often differed from those of primary care physicians, and generally seemed to be healthier.40 The findings may indicate, however, that there are circumstances in which the additional clinical acumen amongst primary care physicians gained by more training and experience may not be required.41
In common with the wider literature, this review also highlighted that PAs' deployment varied between (and within) settings. 32; 2842 Limits on their role, due to lack of regulation and prescribing rights, is understood as a significant barrier in the UK.43 However, aside from regulation, there are other barriers to delegation. In particular, there is evidence of some resistance and hostility from other health care professionals where there is perceived role overlap or competition for training opportunities.42 This resistance appears to lessen when there is greater understanding of the role.43 For PA skills to be utilised appropriately, the whole primary care team need to be clear about and accept the role of PAs in their setting. This role clarity is also required by non-clinicians also to ensure that patients are triaged to the most appropriate clinician.4445 Role clarity does not mean uniformity; evidence from our review and advisory group stakeholders (Box 1) suggested that the flexibility and adaptiveness of the PA role in general can enable PAs to develop in different ways as required by their particular healthcare system.
Conclusions and implications for research, policy and practice
This review suggests that the expansion of PAs working in primary care may maintain the quality of care needed to support cancer diagnosis. This is important, given concerns that PAs might provide poorer quality of care.16192428 It is also important to guide deployment of PAs in contexts like the UK, where, following regulation, their roles could be expanded to cover tasks like ordering of ionizing radiation. The review also highlights important gaps in the evidence base, particularly how primary care workforce changes may impact on the timeliness of cancer diagnosis. For research to explore the impact of new professions on the timeliness of diagnosis, amendments research and monitoring are needed to collect data on consultations with a range of professionals other than physicians.
Although we discovered no adverse outcomes from the introduction of PAs, it is clear that PAs need to be actively integrated into their working environments. Integration of PAs may require strategies for the whole practice. For example, support for clinical supervisors could enable them to maximise safe delegation to PAs. Support to primary care leaders could promote PAs' integration into wider team, through clarifying respective clinical roles.
The context of primary care has altered significantly since the studies in this review were conducted. International guidance on the role of primary care in cancer acknowledges the planned structural shift away from a model of the lone practitioner, but provides no insight into the potential role of PAs.3 In addition, routes to cancer diagnosis have been affected in unforeseen ways by the Covid pandemic. These include, but are not limited to, patients' reluctance to consult primary care when they experience possible cancer symptoms, a switch to remote instead of face-to-face consultations which may decrease clinicians' capacity to spot subtle symptoms, and a delay in diagnostics referrals due to lockdown backlogs and decreased capacity in order to maintain social distancing.46 Further studies should examine the impact of emerging professions such as PAs on timely cancer diagnosis in this new context of primary care.
Ethics approval and consent to participate: not applicable, ethical approval was not required for this study
Consent for publication: not applicable
Availability of data and materials: all data are to be found in the publications references in the article
Competing interests: The authors declare that they have no competing interests
Funding: This paper presents independent research commissioned and funded by the National Institute for Health Research (NIHR) Policy Research Programme, conducted through the Policy Research Unit in Cancer Awareness, Screening and Early Diagnosis, PR-PRU-1217-21601. The views expressed are those of the author(s) and not necessarily those of the NIHR, the Department of Health and Social Care or its arms length bodies, or other Government Departments.
JS was supported by the National Institute for Health Research (NIHR) Applied Research Collaboration North Thames at Bart's Health NHS Trust (NIHR ARC North Thames). The views expressed in this article are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health and Social Care.
The funders had no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
Authors' contributions:
the idea for this study was conceived by JS
development of the protocol was undertaken by AKa, AKi, JS.
paper screening, data extraction and quality appraisal was undertaken by AKa, AKi, MC.
JS produced the initial draft with methods drafted by AKa, AKi
The advisory group provided comments on main findings.
All authors commented on drafts of the manuscript and agreed the decision to submit for publication.
We wish to thank the following for their valuable input into the design and conduct of this study and interpretation of the findings: Georgia Black, Janina Iwaszko, Jane Perry, Sandra Nicholson, Justine Strand de Oliveira, Richard Roope, Charlotte Scott-Wilson and Willie Hamilton & members of the Physician Associates preceptor scheme in North East London.
We also wish to thank Dr Matea Deliu for a review of the policy context leading up the introduction of physician associates in the UK.
Sheringham J, Georghiou T, Chitnis X, et al. Comparing primary and secondary healthcare use between diagnostic routes before a diagnosis of colorectal cancer: Cohort study using linked data Br J Cancer 2014 doi: doi: 10.1038/bjc.2014.424
Swann R, McPhail S, Witt J, et al. Diagnosing cancer in primary care: results from the National Cancer Diagnosis Audit. Brit J Gen Pract 2018;68(666):e63-e72. doi: 10.3399/bjgp17X694169
Banks I, Weller D, Ungan M, et al. ECCO Essential Requirements for Quality Cancer Care: Primary care. Crit Rev Oncol Hemat 2019;142:187–99. doi: https://doi.org/10.1016/j.critrevonc.2019.07.007
NHS England. NHS Long Term Plan 2019 [updated 21 August 2019; cited 2020 8 June 2020]. Available from: https://www.longtermplan.nhs.uk/.
Jabbarpour YG, A; Jetty, A; Coffman, M; et al, A Investing in Primary Care: A State-Level Analysis: Patient-Centered Primary Care Collaborative, 2019. Available from: https://www.pcpcc.org/resource/investing-primary-care-state-level-analysis. Accessed 25 August 2020.
NHS Careers. Roles in the medical associate professions. 2020. Website. Available from: https://www.healthcareers.nhs.uk/explore-roles/medical-associate-professions/roles-medical-associate-professions. Accessed 15 December 2020.
General Medical Council. GMC to regulate two new associates roles, 2019. Available from: https://www.gmc-uk.org/news/news-archive/gmc-to-regulate-two-new-associates-roles---pas-and-aas. Accessed 25 August 2020.
Faculty of Physician Associates. The Department of Health consultation on the regulation of Medical Associate Professionals (MAPs) 2017 [Available from: http://www.fparcp.co.uk/about-fpa/news/the-department-of-health-consultation accessed 23/7/2018 2018.
Primary Care Strategy and NHS Contracts Group and Systems Transformation Group. Network Contract Directed Enhanced Service: Additional Roles Reimbursement Scheme Guidance: NHS England and NHS Improvement, 2019. Available from: https://www.england.nhs.uk/wp-content/uploads/2019/12/network-contract-des-additional-roles-reimbursement-scheme-guidance-december2019.pdf. Accessed 25 August 2020
National Commission on Certification of Physician Assistants I. 2019 Statistical Profile of Certified Physician Assistants: An Annual Report of the National Commission on Certification of Physician Assistants. 2020. Available from: http://www.nccpa.net/research Accessed 25 August 2020
Cawley J, Hooker R. Determinants of the physician assistant/associate concept in global health systems. International Journal of Healthcare 2018;4(1):50–60. doi: https://doi.org/10.5430/ijh.v4n1p50
Halter M, Drennan V, Chattopadhyay K, et al. The contribution of Physician Assistants in primary care: a systematic review. BMC Health Serv Res 2013;13(1):223. doi: 10.1186/1472-6963-13-223
Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 2009;339:b2535. doi: 10.1136/bmj.b2535
Tricco AC, Antony J, Zarin W, et al. A scoping review of rapid review methods. BMC Med 2015;13(1):224. doi: 10.1186/s12916-015-0465-6
Skrobanski H, Ream E, Poole K, et al. Understanding primary care nurses' contribution to cancer early diagnosis: A systematic review. Eur J Oncol Nurs 2019;41:149–64. doi: 10.1016/j.ejon.2019.06.007
Mafi JN, Wee CC, Davis RB, et al. Comparing Use of Low-Value Health Care Services Among U.S. Advanced Practice Clinicians and Physicians. Ann Intern Med 2016;165(4):237–44. doi: 10.7326/M15-2152
Kurtzman ET, Barnow BS. A Comparison of Nurse Practitioners, Physician Assistants, and Primary Care Physicians' Patterns of Practice and Quality of Care in Health Centers. Med Care 2017;55(6):615–22. doi: 10.1097/mlr.0000000000000689
Kepka D, Smith A, Zeruto C, et al. Is provider type associated with cancer screening and prevention: advanced practice registered nurses, physician assistants, and physicians. BMC Cancer 2014;14(1):233. doi: 10.1186/1471-2407-14-233
Johnson D, Ouenes O, Letson D, et al. A Direct Comparison of the Clinical Practice Patterns of Advanced Practice Providers and Doctors. Am J Med 2019;132(11):e778-e85. doi: https://doi.org/10.1016/j.amjmed.2019.05.004
Martin K, Vogel RI, Nagler RH, et al. Mammography Screening Practices in Average-Risk Women Aged 40–49 Years in Primary Care: A Comparison of Physician and Nonphysician Providers in Minnesota. J Womens Health 2020;29(1):91–99. doi: 10.1089/jwh.2018.7436
Tang VL, Shi Y, Fung K, et al. Clinician Factors Associated With Prostate-Specific Antigen Screening in Older Veterans With Limited Life Expectancy. JAMA Intern Med 2016;176(5):654–61. doi: 10.1001/jamainternmed.2016.0695 [published Online First: 2016/04/05]
Hughes DR, Jiang M, Duszak R, Jr. A comparison of diagnostic imaging ordering patterns between advanced practice clinicians and primary care physicians following office-based evaluation and management visits. JAMA Intern Med 2015;175(1):101–7. doi: 10.1001/jamainternmed.2014.6349 [published Online First: 2014/11/25]
Brock DM, Nicholson JG, Hooker RS. Physician Assistant and Nurse Practitioner Malpractice Trends. Med Care Res Rev 2017;74(5):613–24. doi: 10.1177/1077558716659022 [published Online First: 2016/07/28]
Liu H, Robbins M, Mehrotra A, et al. The Impact of Using Mid-level Providers in Face-to-Face Primary Care on Health Care Utilization. Med Care 2017;55(1):12–18. doi: 10.1097/mlr.0000000000000590 [published Online First: 2016/07/02]
Drennan VM, Halter M, Joly L, et al. Physician associates and GPs in primary care: a comparison. Brit J Gen Pract 2015;65(634):e344-50. doi: 10.3399/bjgp15X684877
Feeley TH, Cooper J, Foels T, et al. Efficacy expectations for colorectal cancer screening in primary care: identifying barriers and facilitators for patients and clinicians. Health Communication 2009;24(4):304–15. doi: 10.1080/10410230902889241
Blaes A, Vogel RI, Nagler RH, et al. Breast Cancer Screening Practices for High-Risk Women: A Cross-Sectional Survey of Primary Care Providers. J Womens Health (Larchmt) 2019 doi: 10.1089/jwh.2018.7463 [published Online First: 2019/08/23]
Burrows KE, Abelson J, Miller PA, et al. Understanding health professional role integration in complex adaptive systems: a multiple-case study of physician assistants in Ontario, Canada. BMC Health Serv Res 2020;20(1):365. doi: 10.1186/s12913-020-05087-8
Laird SA, Raudonis BM. Colorectal Cancer Screening Practices Among Texas Nurse Practitioners and Physician Assistants. Gastroenterol Nurs 2020;43(2):156–63. doi: 10.1097/sga.0000000000000414 [published Online First: 2020/04/07]
Boone E, Lewis L, Karp M. Discontent and Confusion: Primary Care Providers' Opinions and Understanding of Current Cervical Cancer Screening Recommendations. J Womens Health (15409996) 2016;25(3):255–62. doi: 10.1089/jwh.2015.5326
Aiello M, Roberts KA. Development of the United Kingdom physician associate profession. JAAPA-J AM ACAD PHYS 2017;30(4):1–8. doi: 10.1097/01.Jaa.0000513357.68395.12
Drennan V HM, Brearley S, Carneiro W, Gabe J, Gage H, et al. Investigating the contribution of physician assistants to primary care in England: A mixed methods study. Health Serv Deliv Res 2014;16(2) doi: https://doi.org/10.3310/hsdr02160
The Lancet. Prioritising primary care in the USA. Lancet 2019;394(10195):273. doi: 10.1016/S0140-6736(19)31678-2
NHS England. Interim People Plan 2019 [updated 6 June 2019; cited 2020 8 June 2020]. Available from: https://www.longtermplan.nhs.uk/publication/interim-nhs-people-plan/ accessed 8 June 2020 2020.
National Institute for Health and Clinical Excellence. Suspected cancer: recognition and referral 2015 [updated June 2015]. Available from: nice.org.uk/guidance/ng12. accessed 21 July 2015.
Mittman DE, Cawley JF, Fenn WH. Physician assistants in the United States. BMJ 2002;325(7362):485–87. doi: 10.1136/bmj.325.7362.485
Hutchison B, Levesque JF, Strumpf E, et al. Primary health care in Canada: systems in motion. Milbank Q 2011;89(2):256–88. doi: 10.1111/j.1468-0009.2011.00628.x [published Online First: 2011/06/17]
Dill M, Pankow S, Erikson C, et al. Survey Shows Consumers Open To A Greater Role For Physician Assistants And Nurse Practitioners. Health Aff 2013;32(6):1135–42. doi: 10.1377/hlthaff.2012.1150
Halter M, Drennan VM, Joly LM, et al. Patients' experiences of consultations with physician associates in primary care in England: A qualitative study. Health Expect 2017;20(5):1011–19. doi: 10.1111/hex.12542
de Lusignan S, McGovern AP, Tahir MA, et al. Physician Associate and General Practitioner Consultations: A Comparative Observational Video Study. PLoS One 2016;11(8):e0160902. doi: 10.1371/journal.pone.0160902 [published Online First: 2016/08/26]
Rich E. Advanced Practice Clinicians and Physicians in Primary Care: Still More Questions than Answers. Ann Intern Med 2016;165(4):290–91. doi: 10.7326/m16-1326 %m 27322738
Nelson PA, Bradley F, Martindale AM, et al. Skill-mix change in general practice: a qualitative comparison of three 'new' non-medical roles in English primary care. Brit J Gen Pract 2019;69(684):e489-e98. doi: 10.3399/bjgp19X704117 [published Online First: 2019/06/05]
Szeto DMC, Till DA, McKimm PJ. Integrating physician associates into the health workforce: barriers and facilitators. Brit J Hospital Med 2019;80(1):12–17. doi: 10.12968/hmed.2019.80.1.12
Andersen RS, Aarhus R. Reconfiguring diagnostic work in Danish general practice; regulation, triage and the secretaries as diagnostician. Anthropol Med 2019;26(2):213–27.
Andersen RS, Vedsted P. Juggling efficiency. An ethnographic study exploring healthcare seeking practices and institutional logics in Danish primary care settings. Soc Sci Med 2015;128:239–45.
Hamilton W. Cancer diagnostic delay in the COVID-19 era: what happens next? Lancet Oncol 2020;21(8):1000–02. doi: 10.1016/S1470-2045(20)30391-0
SupplementarydataDecember2020.docx
Editorial decision: Major revision
Reviews received at journal
Reviewers agreed at journal


Where your future is our #1 commitment!!!
Zenith: Culminating point, the strongest or most successful period of time.
(Ze-nith) - ˈzēniTH: Culminating point, the strongest or most successful period of time. To be at the "Zenith" of your career means you are working at your highest potential on every level.


text:
Tidningsbud är anställda för att dela ut tidningar och liknande utskick.

Tidningsbud i Sverige
I Sverige är tidningsbud ett deltidsyrke för ca 13 000 anställda tidningsbud, som delar ut morgontidningar samt adresserade och oadresserade utskick och försändelser, mellan ett- och sjutiden på morgonen. Ett mindre antal halv- och heltidsanställningar finns. Tidningsbuden är anställda i olika tidningsdistributionsföretag fördelade över landet. Av dessa tidningsbud är cirka 8 000 fot-/cykelbud och cirka 5 000 bilburna.
Varje morgon distribuerar tidningsbuden cirka 3 miljoner exemplar tidningar, varav cirka 2 300 000 exemplar i tätort och 725 000 i landsbygd. Det utgår statligt samdistributionsstöd och presstöd på ca 600 miljoner kronor per år för att både mindre och större tidningar ska delas ut i hela riket, genom ett system av samdistribution.

Arbetsgivare
Morgontidningarnas och tidningsdistributionsföretagens centrala arbetsgivar- och branschorganisation heter Tidningsutgivarna. På deras medlemslista finns alla svenska morgon- och kvällstidningar, flera gratistidningar, nyhets- och bildbyråer, tryckerier, tidningsdistributionsföretag, annonsförsäljningsbolag, några tv- och radiostationer samt förlag.

Regionala arbetsgivare
Pressens Morgontjänst KB (Premo) - Solna
Tidningsbärna KB (TB) - Malmö
Västsvensk Tidningsdistribution KB - Göteborg
Prolog Tidningsdistribution - Västmanland, Eskilstuna, Flen, Katrineholm,Strängnäs och Södertälje
UNT Distribution - större delen av Uppland
NA Distribution - Närke
Svensk Morgondistribution KB - Norrlandskusten från Gävle upp till Sundsvall och Dalarna

Rikstäckande arbetsgivare
Tidningstjänst AB (TAB), Stockholm (både i egen regi och som säljare av olika administrativa tjänster till olika lokala distributionsbolag)

Fackförbund
Tidningsbuden företräds fackligt av Transportarbetareförbundet, som har förhandlingsrätten för tidningsbudens kollektivavtal. Avtalet bygger på månadslön.

Källor
Tidningsutgivarna
Svenska Transportarbetareförbundet

Vidare läsning

Yrken inom media
Tidningar

redpajama_set_name: RedPajamaWikipedia


What is Erosive pustular dermatosis of the scalp (EPDS)?
Erosive pustular dermatosis of the scalp is a relatively uncommon condition and is more likely to affect older individuals than younger.
The cause is not known but it is thought that trauma or injury plays an important role in development of the condition. Patients with a history of extensive sun damage or history of other trauma to the scalp seen to be more likely to develop this condition.
Individuals with the condition often develop crusted erosions on the scalp some of which have pus. The crusts can sometimes be lifted from the scalp to reveal the erosions.
A scalp biopsy can confirm the suspected diagnosis and help rule out other conditions that can look very similar.
What is the treatment for EPDS?
Treatment of erosive pustular dermatosis of the scalp is generally easy.
Topical steroids & topical calcineurin inhibitor drugs (tacrolimus and pimecrolimus) are generally very helpful.


text:
Q: How to generate and ordered, subsetted dataframe that is X elements long or less I have a large data frame (df). I would like to produce df2 from here. df2 must fill these criteria:
1) Sub setted by value in one of the columns.
2) df2 must have a length of 20 elements or less.
3) df2 must be ordered by increasing value
My attempts:
A <- floor(runif(100, min = 1, max = 100))
B <- floor(runif(100, min = 1, max = 100))
as.data.frame(cbind(A, B)) -> df

head(df[which(df$A < 50),], n = 20) -> df2

This works okay but I'd like the output to be 20 elements long or less.
head(df[which(df$A < 50),], n < 20) -> df2

<=/=</<

All result in 'n' not being found.
order(head(df[which(df$A < 20),], decreasing = False)) -> df2

Kind of works but produces a list rather than a data frame. Also when I try my output is not increasing.
Any help would be appreciated.

A: Was trying to do it in one-liner in base R but it was becoming really ugly so here is a two step solution
temp <- df[head(which(df$A < 50), 20), ]
temp[order(temp$A), ]

#    A  B
#4   4 24
#35  7 49
#13  9 16
#39 10 44
#1  12 41
#26 14  8
#14 15 11
#11 16 92
#31 17 17
#20 19 95
#2  20 78
#6  30 94
#16 33 66
#12 34 70
#25 35 21
#9  41 69
#15 41 28
#18 43 37
#5  48 58
#22 49 24

However, with dplyr you can do it in one chain operation
library(dplyr)
df %>%
  filter(A < 50) %>%
  slice(1:20) %>%
  arrange(A)

You can change the value 50 and 20 based on your preference.
data
set.seed(2345)
A <- floor(runif(100, min = 1, max = 100))
B <- floor(runif(100, min = 1, max = 100))
as.data.frame(cbind(A, B)) -> df

redpajama_set_name: RedPajamaStackExchange


text:
Stephen Colbert Net Worth: How Did Colbert Become Deaf?
Elvira L. Jones
In this post, we will explore some fascinating details about the life of the famous comedian Stephen Colbert, including his early life, career, and relationship status, as well as his family and net worth.
Therefore, continue reading till you reach the end to obtain any additional information. Let's get started.
Who is Stephen Colbert?
Stephen Colbert is a Washington, D.C.-based American comedian, writer, producer, actor, and television host. Colbert first became interested in improvisational theatre while studying acting at Northwestern University, where he also met Second City director Del Close.
Colbert made his professional stage debut at Second City Chicago as Steve Carell's replacement while hanging out with Paul Dinello and Amy Sedaris. They worked together on the comic sketch program Exit 57.
He wrote and performed on the short-lived Dana Carvey Show before joining Sedaris and Dinello in Strangers with Candy once more. In the latter, he became well-known for playing Chuck Noblet, a secret gay history teacher.
Nine Primetime Emmy Awards, two Grammy Awards, and three Peabody Awards have all been given to Colbert. I Am America (And So Can You!) by Stephen Colbert topped The New York Times Best Sellers list in 2007. Colbert was listed among Time's 100 Most Influential People in 2006 and 2012.
Stephen Colbert Early Life
Colbert was born in Washington, D.C., the youngest of eleven children, to a Catholic family. He grew up on James Island, a Charleston, South Carolina neighborhood. He spent his early years in Bethesda, Maryland.
Colbert's siblings are James III, Edward, Mary, William, Margo, Thomas, Jay, Elizabeth, Paul, Peter, and Stephen, in descending order of age. His father, immunologist James William Colbert Jr., was dean of the medical school at Yale University, Saint Louis University.
If you want to know about James William Colbert Jr., let us know in the comment section.
Subsequently, the Medical University of South Carolina served as the institution's first vice president of academic affairs in 1969. Stephen's mother, Lorna Elizabeth Colbert (née Tuck), was a homemaker.
On September 11, 1974, Colbert was ten years old when his father and two elder brothers, Peter and Paul, were killed in the crash of Eastern Air Lines Flight 212 attempting to land in Charlotte, North Carolina. They were on their way to Canterbury School in New Milford, Connecticut, to enroll the two boys.
Lorna Colbert, who also ran the carriage house as a bed and breakfast, relocated the family from James Island to the George Chisolm House in downtown Charleston.
More to Read: What is PnB Rock Net Worth? What Caused PnB Rock's Death?
Colbert struggled with the transition and found it challenging to make friends in his new neighborhood. Later, Colbert remembers feeling disinterested and not believing that other students' concerns were essential at the time. He has discussed how it has changed his perspective on suffering and despair.
He began to appreciate science fiction and fantasy literature, notably J. R. R. Tolkien, of whom he remains a tremendous fan. During his adolescence, he also developed a strong interest in fantasy role-playing games, particularly Dungeons & Dragons. This curiosity was later regarded as his initial introduction to acting and improvisation.
Stephen Colbert Career
When Colbert enrolled in some free improvisation lessons in 1988, he started his career.
In 1995, he moved to New York from Second City to work on the television comedy series "Exit 57" with Dinello and Sedaris. Despite receiving positive reviews, the series only had 12 episodes.
Along with Steve Carell, Robert Smigel, and Dino Stamatopoulos, he worked as a writer and cast member on "The Dana Carvey Show" in 1996. However, the series was terminated because the humor was offensive.
For Comic Central, Colbert collaborated on the new comedy series Strangers with Candy with Sedaris, Dinello, and others. Its 32 episodes, known as cult shows, were broadcast between 1999 and 2000.
His satire targeted President Bush and the media at the White House Correspondents' Association Dinner in 2006, where he performed as the main attraction. He silenced the audience with his performance but became viral online.
In 2007, he published the political satire-filled book I Am America (And So Can You! ), with only a minor contribution from his writing team.
What is Stephen Colbert's Net Worth?
Stephen Colbert is an American comedian, writer, actor, author, and talk show host. According to CelebrityNetworth.com, His net worth is now estimated to be $75 million.
After hosting "The Colbert Report" on Comedy Central from 2005 until 2014, Stephen Colbert became the presenter of "The Late Show with Stephen Colbert" on CBS, which he began hosting in 2015.
Kim Kardashian Net Worth 2022: What Religion Does Kim Kardashian Follow?
Lisa Marie Presley Net Worth 2022: Lisa Marie's Financial Problems!
Stephen Colbert's Other Projects
Outside of television, Colbert has a variety of interests. He played at the WHCA Dinner in 2006. He satirized the Bush Administration and the White House Press Corps in character from "The Colbert Report," and a video of his performance went viral, with "The Colbert Report" viewership increasing 37% in the week following the event.
Colbert has appeared on "Curb Your Enthusiasm," "Spin City," and "Law & Order: Criminal Intent," as well as in "Bewitched." He has also voiced characters on "The Venture Bros.," "Crank Yankers," "American Dad!" and "The Simpsons."
Colbert collaborated with Sedaris and Dinello on the satirical novel Wigfield.
How Did Colbert Become Deaf?
This individual, who is 56 years old, is deaf in his right ear. The presenter of "The Late Show" stated that he had lost his hearing as a child when doctors attempted to remove a tumor from his head.
He had a prosperous career, but his true calling was to work as a marine biologist. Unfortunately, the damage to his ear prevented him from being able to scuba dive when he was younger.
Who is the Wife of Stephen Colbert?
Since 1993, Colbert has been married to Evelyn "Evie" McGee-Colbert. Madeleine, Peter, and John are their three children. The family currently resides in Montclair, New Jersey.
He considers himself a Democrat and a committed Roman Catholic. He is also a Universal Life Church Monastery ordained minister.
Do you want to know more about Stephen Colbert's wife, Evelyn McGee, let us know in the comment section.
Will Stephen Colbert Ever Stop Hosting?
Stephen Colbert, the reigning late-night king, will remain on The Late Show until the 2020 election and beyond. CBS has extended the comedian's contract to keep him a host of The Late Show with Stephen Colbert through August 2023.
Why is Stephen Colbert's Show Coming to an End?
Stephen is exhibiting symptoms of a COVID relapse. He will remain isolated for a few more days out of concern for his employees, guests, and audience. No further episodes of The Late Show will be taped until further notice.
Stephen Colbert Wears What Kind of Suits?
Colbert can compete with other late-night opponents like Jimmy Fallon by wearing bespoke clothes because they fit him much better and make him appear younger. These specialized outfits have also helped Stephen Colbert shed his "funny guy" tag by convincing viewers to take the show more seriously.

redpajama_set_name: RedPajamaCommonCrawl


text:
Wolfgang Arendt (né le  à Herzberg (Elster), Allemagne) est un mathématicien allemand, professeur de mathématiques à l'université d'Ulm. Ses travaux portent sur l'analyse fonctionnelle et les équations d'évolution.

Formation et carrière

Wolfgang Arendt a fait ses études de mathématiques et physiques à l'Université libre de Berlin (1968-1975), l'Université de Nice Sophia Antipolis et à l'Université Eberhard Karl de Tübingen. Il a obtenu son doctorat, dirigé par Helmut H. Schaefer, en 1979 à l'université de Tübingen (Über das Spektrum regulärer Operatoren). De 1980 à 1981, il poursuit ses recherches (Post-doc) à l'Université de Californie à Berkeley sous la direction de Tosio Kato, puis obtient sont habilitation universitaire en 1984 à l'université de Tübingen (Generators of positive semigroups and resolvent positive operators). De 1987 à 1995, il est professeur à l'Université de Franche-Comté. Depuis 1995, Wolfgang Arendt est professeur à l'Université d'Ulm où il est directeur de l'Institut d'Analyse Appliquée.

Recherche et enseignement

Wolfgang Arendt s'est spécialisé dans les méthodes d'analyse fonctionnelle pour les équations aux dérivées partielles. Plus particulièrement,
il travaille sur les semi-groupes fortement continus. Ses articles de recherche les plus cités traitent de l'interaction entre les semi-groupes fortement continus et la transformation de Laplace à valeurs vectorielles, les treillis de Banach et l'analyse harmonique. L'un de ses résultats les plus célèbres est le .

Arendt a dirigé plus de 25 thèses et a publié plus de 100 articles scientifiques. Parmi ses responsabilités éditoriales, il est rédacteur en chef du Journal of Evolution Equations.

Avec ses collègues de Tübingen et Karlsruhe, il a fondé le groupe de travail TULKA (TübingenULmKArlsruhe) , qui est une collaboration inter-universitaire de plusieurs équipes d'analyse fonctionnelle.
De plus, il est membre fondateur du séminaire international annuelle ISEM sur les équations d'évolution.

Bibliographie

  Wolfgang Arendt, Annette Grabosch, Günther Greiner, Ulrich Moustakas, Rainer Nagel et Ulf Schlotterbeck, One-Parameter Semigroups of Positive Operators, Springer-Verlag, Berlin 1986
  Wolfgang Arendt, Charles J. K. Batty, Matthias Hieber et Frank Neubrander, Vector-valued Laplace transforms and Cauchy problems, Monographs in Mathematics, 96. Birkhäuser Verlag, Basel 2001

Liens externes

  Site web de Wolfgang Arendt
  Liste de publications de Wolfgang Arendt

Références

Mathématicien allemand du XXe siècle
Mathématicien allemand du XXIe siècle
Professeur à l'université d'Ulm
Enseignant à l'université de Franche-Comté
Naissance en mars 1950
Naissance à Herzberg (Elster)


The last round in the rush process before KTP begins handing out bids! Rushees will be interviewed individually by our active members. Interviewees will be asked to answer questions about themselves along with what they are passionate about. Interviewees will then be given 2-3 logic story problems to solve within an allotted time. Finally, interviewees will be asked about their interest in Kappa Theta Pi as well as what they can gain and contrbute from and to Kappa Theta Pi.
© 2018 Kappa Theta Pi Alpha Chapter. All Rights Reserved.