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Project acronym 2shRNA
Project 2shRNA branched nanobinders as promising therapeutic tools for combined cancer therapy
Researcher (PI) Modesto Orozco López
Host Institution (HI) FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
Call Details
Summary This project aims to optimize and validate a promising therapeutic tool for combined cancer therapy, 2shRNA, in an ex vivo model system. Combined therapies are of great significance nowadays, due to their key role in fighting, for instances, resistance processes during cancer treatment. Nonetheless, the drug combinations approved to date face several problems, such as cooperative toxicity effects, lack of efficiency and poor bioavailability. We have designed and synthesized 2shRNA, a new bifunctional RNA tool that can simultaneously attack two therapeutic targets involved in drug resistance pathways, and that can additionally bind other molecules such as peptide carriers or fluorophores, to improve delivery and efficacy. The 2shRNA nanostructure displayed low toxicity and excellent anti-proliferative properties in resistant HER2+ breast cancer cell lines. The present proposal is aimed at optimizing and validating this novel and promising RNA tool by combining state-of-the-art bioinformatics design and cycles of chemical refinement with biological evaluation in PDx-derived primary cell cultures and biodistribution studies in PDx mouse models. The proposed strategy presents a novel therapeutic approach with great potential to circumvent drug resistance in breast cancer, which is a major health challenge for our society. The ability of our biostable RNA tool to administer two drugs in a single dose could improve the quality of life of the patients, as fewer doses might be needed to stall disease progression.
This project aims to optimize and validate a promising therapeutic tool for combined cancer therapy, 2shRNA, in an ex vivo model system. Combined therapies are of great significance nowadays, due to their key role in fighting, for instances, resistance processes during cancer treatment. Nonetheless, the drug combinations approved to date face several problems, such as cooperative toxicity effects, lack of efficiency and poor bioavailability. We have designed and synthesized 2shRNA, a new bifunctional RNA tool that can simultaneously attack two therapeutic targets involved in drug resistance pathways, and that can additionally bind other molecules such as peptide carriers or fluorophores, to improve delivery and efficacy. The 2shRNA nanostructure displayed low toxicity and excellent anti-proliferative properties in resistant HER2+ breast cancer cell lines. The present proposal is aimed at optimizing and validating this novel and promising RNA tool by combining state-of-the-art bioinformatics design and cycles of chemical refinement with biological evaluation in PDx-derived primary cell cultures and biodistribution studies in PDx mouse models. The proposed strategy presents a novel therapeutic approach with great potential to circumvent drug resistance in breast cancer, which is a major health challenge for our society. The ability of our biostable RNA tool to administer two drugs in a single dose could improve the quality of life of the patients, as fewer doses might be needed to stall disease progression.
Project acronym 3D-COUNT
Project 3D-Integrated single photon detector
Researcher (PI) Fabio SCIARRINO
Host Institution (HI) UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Summary Photonics, in recognition of its strategic significance and pervasiveness throughout many industrial sectors, has been identified as one of the Key Enabling Technologies for Europe. Photonics in combination with quantum information science has great potential to facilitate, transform and innovate future technologies for the better. The Proof of Concept (PoC) project intends to contribute to this by developing and testing a communication platform prototype, comprised of single photon detectors, which are efficiently coupled to single mode fibers using an innovative laser written device. This enables the integration of single photon detectors on innovative glass waveguides. These glass integrated photonic circuits offer excellent specifics for on-chip quantum optics implementations in terms of scattering losses, offering flexibility of the waveguide geometry and ensuring high coupling efficiency with optical fibers. The device developed and tested in the PoC, directly addresses a market need for an integrated and efficient on-chip communication systems. Current available systems have limitations involving high costs, complex production, and inefficient coupling of detectors to optical fibers. The proposed platform will offer 1.) a simplified production process, 2.) high optical fiber coupling efficiency 3.) improved performance levels, 4.) high cost efficiency, and 5.) compactness. Such systems can be applied in a wide range of communication and non-communication applications, such as free-space optical communication, quantum communication, quantum cryptography, DNA sequencing, single molecule detection and material analysis. Moreover, the future commercialisation of quantum computing is expected to create a vast demand for these communication systems. In addition to the technology PoC, the project carries out IPR strategy considerations through patenting actions, determines the market potential, seeks market feedback, and plans for post-PoC commercialisation paths.
Photonics, in recognition of its strategic significance and pervasiveness throughout many industrial sectors, has been identified as one of the Key Enabling Technologies for Europe. Photonics in combination with quantum information science has great potential to facilitate, transform and innovate future technologies for the better. The Proof of Concept (PoC) project intends to contribute to this by developing and testing a communication platform prototype, comprised of single photon detectors, which are efficiently coupled to single mode fibers using an innovative laser written device. This enables the integration of single photon detectors on innovative glass waveguides. These glass integrated photonic circuits offer excellent specifics for on-chip quantum optics implementations in terms of scattering losses, offering flexibility of the waveguide geometry and ensuring high coupling efficiency with optical fibers. The device developed and tested in the PoC, directly addresses a market need for an integrated and efficient on-chip communication systems. Current available systems have limitations involving high costs, complex production, and inefficient coupling of detectors to optical fibers. The proposed platform will offer 1.) a simplified production process, 2.) high optical fiber coupling efficiency 3.) improved performance levels, 4.) high cost efficiency, and 5.) compactness. Such systems can be applied in a wide range of communication and non-communication applications, such as free-space optical communication, quantum communication, quantum cryptography, DNA sequencing, single molecule detection and material analysis. Moreover, the future commercialisation of quantum computing is expected to create a vast demand for these communication systems. In addition to the technology PoC, the project carries out IPR strategy considerations through patenting actions, determines the market potential, seeks market feedback, and plans for post-PoC commercialisation paths.
Project acronym 3D-FABRIC
Project 3D Flow Analysis in Bijels Reconfigured for Interfacial Catalysis
Researcher (PI) Martin F. HAASE
Host Institution (HI) UNIVERSITEIT UTRECHT
Summary The objective of this proposal is to determine the unknown criteria for convective cross-flow in bicontinuous interfacially jammed emulsion gels (bijels). Based on this, we will answer the question: Can continuously operated interfacial catalysis be realized in bijel cross-flow reactors? Demonstrating this potential will introduce a broadly applicable chemical technology, replacing wasteful chemical processes that require organic solvents. We will achieve our objective in three steps: (a) Control over bijel structure and properties. Bijels will be formed with a selection of functional inorganic colloidal particles. Nanoparticle surface modifications will be developed and extensively characterized. General principles for the parameters determining bijel structures and properties will be established based on confocal and electron microscopy characterization. These principles will enable unprecedented control over bijel formation and will allow for designing desired properties. (b) Convective flow in bijels. The mechanical strength of bijels will be tailored and measured. With mechanically robust bijels, the influence of size and organization of oil/water channels on convective mass transfer in bijels will be investigated. To this end, a bijel mass transfer apparatus fabricated by 3d-printing of bijel fibers and soft photolithography will be introduced. In conjunction with the following objective, the analysis of convective flows in bijels will facilitate a thorough description of their structure/function relationships. (c) Biphasic chemical reactions in STrIPS bijel cross-flow reactors. First, continuous extraction in bijels will be realized. Next, conditions to carry out continuously-operated, phase transfer catalysis of well-known model reactions in bijels will be determined. Both processes will be characterized in-situ and in 3-dimensions by confocal microscopy of fluorescent phase transfer reactions in transparent bijels.
The objective of this proposal is to determine the unknown criteria for convective cross-flow in bicontinuous interfacially jammed emulsion gels (bijels). Based on this, we will answer the question: Can continuously operated interfacial catalysis be realized in bijel cross-flow reactors? Demonstrating this potential will introduce a broadly applicable chemical technology, replacing wasteful chemical processes that require organic solvents. We will achieve our objective in three steps: (a) Control over bijel structure and properties. Bijels will be formed with a selection of functional inorganic colloidal particles. Nanoparticle surface modifications will be developed and extensively characterized. General principles for the parameters determining bijel structures and properties will be established based on confocal and electron microscopy characterization. These principles will enable unprecedented control over bijel formation and will allow for designing desired properties. (b) Convective flow in bijels. The mechanical strength of bijels will be tailored and measured. With mechanically robust bijels, the influence of size and organization of oil/water channels on convective mass transfer in bijels will be investigated. To this end, a bijel mass transfer apparatus fabricated by 3d-printing of bijel fibers and soft photolithography will be introduced. In conjunction with the following objective, the analysis of convective flows in bijels will facilitate a thorough description of their structure/function relationships. (c) Biphasic chemical reactions in STrIPS bijel cross-flow reactors. First, continuous extraction in bijels will be realized. Next, conditions to carry out continuously-operated, phase transfer catalysis of well-known model reactions in bijels will be determined. Both processes will be characterized in-situ and in 3-dimensions by confocal microscopy of fluorescent phase transfer reactions in transparent bijels.
Project acronym 3D-JOINT
Project 3D Bioprinting of JOINT Replacements
Researcher (PI) Johannes Jos Malda
Host Institution (HI) UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Summary The world has a significant medical challenge in repairing injured or diseased joints. Joint degeneration and its related pain is a major socio-economic burden that will increase over the next decade and is currently addressed by implanting a metal prosthesis. For the long term, the ideal solution to joint injury is to successfully regenerate rather than replace the damaged cartilage with synthetic implants. Recent advances in key technologies are now bringing this "holy grail" within reach; regenerative approaches, based on cell therapy, are already clinically available albeit only for smaller focal cartilage defects. One of these key technologies is three-dimensional (3D) bio-printing, which provides a greatly controlled placement and organization of living constructs through the layer-by-layer deposition of materials and cells. These tissue constructs can be applied as tissue models for research and screening. However, the lack of biomechanical properties of these tissue constructs has hampered their application to the regeneration of damaged, degenerated or diseased tissue. Having established a cartilage-focussed research laboratory in the University Medical Center Utrecht, I have addressed this biomechanical limitation of hydrogels through the use of hydrogel composites. Specifically, I have pioneered a 3D bio-printing technology that combines accurately printed small diameter thermoplast filaments with cell invasive hydrogels to form strong fibre-reinforced constructs. This, in combination with bioreactor technology, is the key to the generation of larger, complex tissue constructs with cartilage-like biomechanical resilience. With 3D-JOINT I will use my in-depth bio-printing and bioreactor knowledge and experience to develop a multi-phasic 3D-printed biological replacement of the joint.
The world has a significant medical challenge in repairing injured or diseased joints. Joint degeneration and its related pain is a major socio-economic burden that will increase over the next decade and is currently addressed by implanting a metal prosthesis. For the long term, the ideal solution to joint injury is to successfully regenerate rather than replace the damaged cartilage with synthetic implants. Recent advances in key technologies are now bringing this "holy grail" within reach; regenerative approaches, based on cell therapy, are already clinically available albeit only for smaller focal cartilage defects. One of these key technologies is three-dimensional (3D) bio-printing, which provides a greatly controlled placement and organization of living constructs through the layer-by-layer deposition of materials and cells. These tissue constructs can be applied as tissue models for research and screening. However, the lack of biomechanical properties of these tissue constructs has hampered their application to the regeneration of damaged, degenerated or diseased tissue. Having established a cartilage-focussed research laboratory in the University Medical Center Utrecht, I have addressed this biomechanical limitation of hydrogels through the use of hydrogel composites. Specifically, I have pioneered a 3D bio-printing technology that combines accurately printed small diameter thermoplast filaments with cell invasive hydrogels to form strong fibre-reinforced constructs. This, in combination with bioreactor technology, is the key to the generation of larger, complex tissue constructs with cartilage-like biomechanical resilience. With 3D-JOINT I will use my in-depth bio-printing and bioreactor knowledge and experience to develop a multi-phasic 3D-printed biological replacement of the joint.
Project acronym 3D-nanoMorph
Project Label-free 3D morphological nanoscopy for studying sub-cellular dynamics in live cancer cells with high spatio-temporal resolution
Researcher (PI) Krishna AGARWAL
Host Institution (HI) UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET
Summary Label-free optical nanoscopy, free from photobleaching and photochemical toxicity of fluorescence labels and yielding 3D morphological resolution of <50 nm, is the future of live cell imaging. 3D-nanoMorph breaks the diffraction barrier and shifts the paradigm in label-free nanoscopy, providing isotropic 3D resolution of <50 nm. To achieve this, 3D-nanoMorph performs non-linear inverse scattering for the first time in nanoscopy and decodes scattering between sub-cellular structures (organelles). 3D-nanoMorph innovatively devises complementary roles of light measurement system and computational nanoscopy algorithm. A novel illumination system and a novel light collection system together enable measurement of only the most relevant intensity component and create a fresh perspective about label-free measurements. A new computational nanoscopy approach employs non-linear inverse scattering. Harnessing non-linear inverse scattering for resolution enhancement in nanoscopy opens new possibilities in label-free 3D nanoscopy. I will apply 3D-nanoMorph to study organelle degradation (autophagy) in live cancer cells over extended duration with high spatial and temporal resolution, presently limited by the lack of high-resolution label-free 3D morphological nanoscopy. Successful 3D mapping of nanoscale biological process of autophagy will open new avenues for cancer treatment and showcase 3D-nanoMorph for wider applications. My cross-disciplinary expertise of 14 years spanning inverse problems, electromagnetism, optical microscopy, integrated optics and live cell nanoscopy paves path for successful implementation of 3D-nanoMorph.
Label-free optical nanoscopy, free from photobleaching and photochemical toxicity of fluorescence labels and yielding 3D morphological resolution of <50 nm, is the future of live cell imaging. 3D-nanoMorph breaks the diffraction barrier and shifts the paradigm in label-free nanoscopy, providing isotropic 3D resolution of <50 nm. To achieve this, 3D-nanoMorph performs non-linear inverse scattering for the first time in nanoscopy and decodes scattering between sub-cellular structures (organelles). 3D-nanoMorph innovatively devises complementary roles of light measurement system and computational nanoscopy algorithm. A novel illumination system and a novel light collection system together enable measurement of only the most relevant intensity component and create a fresh perspective about label-free measurements. A new computational nanoscopy approach employs non-linear inverse scattering. Harnessing non-linear inverse scattering for resolution enhancement in nanoscopy opens new possibilities in label-free 3D nanoscopy. I will apply 3D-nanoMorph to study organelle degradation (autophagy) in live cancer cells over extended duration with high spatial and temporal resolution, presently limited by the lack of high-resolution label-free 3D morphological nanoscopy. Successful 3D mapping of nanoscale biological process of autophagy will open new avenues for cancer treatment and showcase 3D-nanoMorph for wider applications. My cross-disciplinary expertise of 14 years spanning inverse problems, electromagnetism, optical microscopy, integrated optics and live cell nanoscopy paves path for successful implementation of 3D-nanoMorph.
Project acronym 3D-QUEST
Project 3D-Quantum Integrated Optical Simulation
Summary "Quantum information was born from the merging of classical information and quantum physics. Its main objective consists of understanding the quantum nature of information and learning how to process it by using physical systems which operate by following quantum mechanics laws. Quantum simulation is a fundamental instrument to investigate phenomena of quantum systems dynamics, such as quantum transport, particle localizations and energy transfer, quantum-to-classical transition, and even quantum improved computation, all tasks that are hard to simulate with classical approaches. Within this framework integrated photonic circuits have a strong potential to realize quantum information processing by optical systems. The aim of 3D-QUEST is to develop and implement quantum simulation by exploiting 3-dimensional integrated photonic circuits. 3D-QUEST is structured to demonstrate the potential of linear optics to implement a computational power beyond the one of a classical computer. Such ""hard-to-simulate"" scenario is disclosed when multiphoton-multimode platforms are realized. The 3D-QUEST research program will focus on three tasks of growing difficulty. A-1. To simulate bosonic-fermionic dynamics with integrated optical systems acting on 2 photon entangled states. A-2. To pave the way towards hard-to-simulate, scalable quantum linear optical circuits by investigating m-port interferometers acting on n-photon states with n>2. A-3. To exploit 3-dimensional integrated structures for the observation of new quantum optical phenomena and for the quantum simulation of more complex scenarios. 3D-QUEST will exploit the potential of the femtosecond laser writing integrated waveguides. This technique will be adopted to realize 3-dimensional capabilities and high flexibility, bringing in this way the optical quantum simulation in to new regime."
"Quantum information was born from the merging of classical information and quantum physics. Its main objective consists of understanding the quantum nature of information and learning how to process it by using physical systems which operate by following quantum mechanics laws. Quantum simulation is a fundamental instrument to investigate phenomena of quantum systems dynamics, such as quantum transport, particle localizations and energy transfer, quantum-to-classical transition, and even quantum improved computation, all tasks that are hard to simulate with classical approaches. Within this framework integrated photonic circuits have a strong potential to realize quantum information processing by optical systems. The aim of 3D-QUEST is to develop and implement quantum simulation by exploiting 3-dimensional integrated photonic circuits. 3D-QUEST is structured to demonstrate the potential of linear optics to implement a computational power beyond the one of a classical computer. Such ""hard-to-simulate"" scenario is disclosed when multiphoton-multimode platforms are realized. The 3D-QUEST research program will focus on three tasks of growing difficulty. A-1. To simulate bosonic-fermionic dynamics with integrated optical systems acting on 2 photon entangled states. A-2. To pave the way towards hard-to-simulate, scalable quantum linear optical circuits by investigating m-port interferometers acting on n-photon states with n>2. A-3. To exploit 3-dimensional integrated structures for the observation of new quantum optical phenomena and for the quantum simulation of more complex scenarios. 3D-QUEST will exploit the potential of the femtosecond laser writing integrated waveguides. This technique will be adopted to realize 3-dimensional capabilities and high flexibility, bringing in this way the optical quantum simulation in to new regime."
Project acronym 3DNANOMECH
Project Three-dimensional molecular resolution mapping of soft matter-liquid interfaces
Researcher (PI) Ricardo Garcia
Host Institution (HI) AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Summary Optical, electron and probe microscopes are enabling tools for discoveries and knowledge generation in nanoscale sicence and technology. High resolution –nanoscale or molecular-, noninvasive and label-free imaging of three-dimensional soft matter-liquid interfaces has not been achieved by any microscopy method. Force microscopy (AFM) is considered the second most relevant advance in materials science since 1960. Despite its impressive range of applications, the technique has some key limitations. Force microscopy has not three dimensional depth. What lies above or in the subsurface is not readily characterized. 3DNanoMech proposes to design, build and operate a high speed force-based method for the three-dimensional characterization soft matter-liquid interfaces (3D AFM). The microscope will combine a detection method based on force perturbations, adaptive algorithms, high speed piezo actuators and quantitative-oriented multifrequency approaches. The development of the microscope cannot be separated from its applications: imaging the error-free DNA repair and to understand the relationship existing between the nanomechanical properties and the malignancy of cancer cells. Those problems encompass the different spatial –molecular-nano-mesoscopic- and time –milli to seconds- scales of the instrument. In short, 3DNanoMech aims to image, map and measure with picoNewton, millisecond and angstrom resolution soft matter surfaces and interfaces in liquid. The long-term vision of 3DNanoMech is to replace models or computer animations of bimolecular-liquid interfaces by real time, molecular resolution maps of properties and processes.
Optical, electron and probe microscopes are enabling tools for discoveries and knowledge generation in nanoscale sicence and technology. High resolution –nanoscale or molecular-, noninvasive and label-free imaging of three-dimensional soft matter-liquid interfaces has not been achieved by any microscopy method. Force microscopy (AFM) is considered the second most relevant advance in materials science since 1960. Despite its impressive range of applications, the technique has some key limitations. Force microscopy has not three dimensional depth. What lies above or in the subsurface is not readily characterized. 3DNanoMech proposes to design, build and operate a high speed force-based method for the three-dimensional characterization soft matter-liquid interfaces (3D AFM). The microscope will combine a detection method based on force perturbations, adaptive algorithms, high speed piezo actuators and quantitative-oriented multifrequency approaches. The development of the microscope cannot be separated from its applications: imaging the error-free DNA repair and to understand the relationship existing between the nanomechanical properties and the malignancy of cancer cells. Those problems encompass the different spatial –molecular-nano-mesoscopic- and time –milli to seconds- scales of the instrument. In short, 3DNanoMech aims to image, map and measure with picoNewton, millisecond and angstrom resolution soft matter surfaces and interfaces in liquid. The long-term vision of 3DNanoMech is to replace models or computer animations of bimolecular-liquid interfaces by real time, molecular resolution maps of properties and processes.
Project acronym 3DScavengers
Project Three-dimensional nanoscale design for the all-in-one solution to environmental multisource energy scavenging
Researcher (PI) Ana Isabel BORRAS MARTOS
Summary Imagine a technology for powering your smart devices by recovering energy from lights in your office, the random movements of your body while reading these lines or from small changes in temperature when you breathe or go out for a walk. This very technology will provide energy for wireless sensor networks monitoring the air in your city or the structural stability of buildings and large constructions remotely and sustainably, avoiding battery recharging or even replacing them. These are the challenges in micro energy harvesting from (local) ambient sources. Kinetic, thermal and solar energies are ubiquitous at our surroundings under diverse forms, but their relatively low intensity and intermittent availability limit their potential recovery by microscale devices. These restrictions call for multi-source energy harvesters working under two principles: 1) combining different single-source harvesters in one device, or 2) using multifunctional materials capable of simultaneously converting various energy sources into electricity. In 1), efficiency per unit volume can decrease compared to the individual counterparts; in 2), materials as semiconductors, polymeric and oxide ferroelectrics and hybrid perovskites may act as multisource harvesters but huge advances are required to optimize their functionalities and sustainable fabrication at large scale. I propose to fill the gap between these approaches offering an all-in-one solution to multisource energy scavenging, based on the nanoscale design of multifunctional three-dimensional materials. The demonstration of an industrially scalable one-reactor plasma/vacuum method will be crucial to integrate hybrid-scavenging components and to provide 3DScavengers materials with tailored microstructure-enhanced performance. My ultimate goal is to build nanoarchitectures for simultaneous and enhanced individual scavenging applying photovoltaic, piezo- and pyro-electric effects, minimizing the environmental cost of their synthesis
Imagine a technology for powering your smart devices by recovering energy from lights in your office, the random movements of your body while reading these lines or from small changes in temperature when you breathe or go out for a walk. This very technology will provide energy for wireless sensor networks monitoring the air in your city or the structural stability of buildings and large constructions remotely and sustainably, avoiding battery recharging or even replacing them. These are the challenges in micro energy harvesting from (local) ambient sources. Kinetic, thermal and solar energies are ubiquitous at our surroundings under diverse forms, but their relatively low intensity and intermittent availability limit their potential recovery by microscale devices. These restrictions call for multi-source energy harvesters working under two principles: 1) combining different single-source harvesters in one device, or 2) using multifunctional materials capable of simultaneously converting various energy sources into electricity. In 1), efficiency per unit volume can decrease compared to the individual counterparts; in 2), materials as semiconductors, polymeric and oxide ferroelectrics and hybrid perovskites may act as multisource harvesters but huge advances are required to optimize their functionalities and sustainable fabrication at large scale. I propose to fill the gap between these approaches offering an all-in-one solution to multisource energy scavenging, based on the nanoscale design of multifunctional three-dimensional materials. The demonstration of an industrially scalable one-reactor plasma/vacuum method will be crucial to integrate hybrid-scavenging components and to provide 3DScavengers materials with tailored microstructure-enhanced performance. My ultimate goal is to build nanoarchitectures for simultaneous and enhanced individual scavenging applying photovoltaic, piezo- and pyro-electric effects, minimizing the environmental cost of their synthesis
Project acronym 3DSPIN
Project 3-Dimensional Maps of the Spinning Nucleon
Researcher (PI) Alessandro Bacchetta
Host Institution (HI) UNIVERSITA DEGLI STUDI DI PAVIA
Summary How does the inside of the proton look like? What generates its spin?
3DSPIN will deliver essential information to answer these questions at the frontier of subnuclear physics. At present, we have detailed maps of the distribution of quarks and gluons in the nucleon in 1D (as a function of their momentum in a single direction). We also know that quark spins account for only about 1/3 of the spin of the nucleon. 3DSPIN will lead the way into a new stage of nucleon mapping, explore the distribution of quarks in full 3D momentum space and obtain unprecedented information on orbital angular momentum. Goals 1. extract from experimental data the 3D distribution of quarks (in momentum space), as described by Transverse-Momentum Distributions (TMDs); 2. obtain from TMDs information on quark Orbital Angular Momentum (OAM). Methodology 3DSPIN will implement state-of-the-art fitting procedures to analyze relevant experimental data and extract quark TMDs, similarly to global fits of standard parton distribution functions. Information about quark angular momentum will be obtained through assumptions based on theoretical considerations. The next five years represent an ideal time window to accomplish our goals, thanks to the wealth of expected data from deep-inelastic scattering experiments (COMPASS, Jefferson Lab), hadronic colliders (Fermilab, BNL, LHC), and electron-positron colliders (BELLE, BABAR). The PI has a strong reputation in this field. The group will operate in partnership with the Italian National Institute of Nuclear Physics and in close interaction with leading experts and experimental collaborations worldwide. Impact Mapping the 3D structure of chemical compounds has revolutionized chemistry. Similarly, mapping the 3D structure of the nucleon will have a deep impact on our understanding of the fundamental constituents of matter. We will open new perspectives on the dynamics of quarks and gluons and sharpen our view of high-energy processes involving nucleons.
How does the inside of the proton look like? What generates its spin?
3DSPIN will deliver essential information to answer these questions at the frontier of subnuclear physics. At present, we have detailed maps of the distribution of quarks and gluons in the nucleon in 1D (as a function of their momentum in a single direction). We also know that quark spins account for only about 1/3 of the spin of the nucleon. 3DSPIN will lead the way into a new stage of nucleon mapping, explore the distribution of quarks in full 3D momentum space and obtain unprecedented information on orbital angular momentum. Goals 1. extract from experimental data the 3D distribution of quarks (in momentum space), as described by Transverse-Momentum Distributions (TMDs); 2. obtain from TMDs information on quark Orbital Angular Momentum (OAM). Methodology 3DSPIN will implement state-of-the-art fitting procedures to analyze relevant experimental data and extract quark TMDs, similarly to global fits of standard parton distribution functions. Information about quark angular momentum will be obtained through assumptions based on theoretical considerations. The next five years represent an ideal time window to accomplish our goals, thanks to the wealth of expected data from deep-inelastic scattering experiments (COMPASS, Jefferson Lab), hadronic colliders (Fermilab, BNL, LHC), and electron-positron colliders (BELLE, BABAR). The PI has a strong reputation in this field. The group will operate in partnership with the Italian National Institute of Nuclear Physics and in close interaction with leading experts and experimental collaborations worldwide. Impact Mapping the 3D structure of chemical compounds has revolutionized chemistry. Similarly, mapping the 3D structure of the nucleon will have a deep impact on our understanding of the fundamental constituents of matter. We will open new perspectives on the dynamics of quarks and gluons and sharpen our view of high-energy processes involving nucleons.
Project acronym 3MC
Project 3D Model Catalysts to explore new routes to sustainable fuels
Researcher (PI) Petra Elisabeth De jongh
Summary Currently fuels, plastics, and drugs are predominantly manufactured from oil. A transition towards renewable resources critically depends on new catalysts, for instance to convert small molecules (such as solar or biomass derived hydrogen, carbon monoxide, water and carbon dioxide) into more complex ones (such as oxygenates, containing oxygen atoms in their structure). Catalyst development now often depends on trial and error rather than rational design, as the heterogeneity of these composite systems hampers detailed understanding of the role of each of the components. I propose 3D model catalysts as a novel enabling tool to overcome this problem. Their well-defined nature allows unprecedented precision in the variation of structural parameters (morphology, spatial distribution) of the individual components, while at the same time they mimic real catalysts closely enough to allow testing under industrially relevant conditions. Using this approach I will address fundamental questions, such as: * What are the mechanisms (structural, electronic, chemical) by which non-metal promoters influence the functionality of copper-based catalysts? * Which nanoalloys can be formed, how does their composition influence the surface active sites and catalytic functionality under reaction conditions? * Which size and interface effects occur, and how can we use them to tune the actitivity and selectivity towards desired products? Our 3D model catalysts will be assembled from ordered mesoporous silica and carbon support materials and Cu-based promoted and bimetallic nanoparticles. The combination with high resolution characterization and testing under realistic conditions allows detailed insight into the role of the different components; critical for the rational design of novel catalysts for a future more sustainable production of chemicals and fuels from renewable resources.
Currently fuels, plastics, and drugs are predominantly manufactured from oil. A transition towards renewable resources critically depends on new catalysts, for instance to convert small molecules (such as solar or biomass derived hydrogen, carbon monoxide, water and carbon dioxide) into more complex ones (such as oxygenates, containing oxygen atoms in their structure). Catalyst development now often depends on trial and error rather than rational design, as the heterogeneity of these composite systems hampers detailed understanding of the role of each of the components. I propose 3D model catalysts as a novel enabling tool to overcome this problem. Their well-defined nature allows unprecedented precision in the variation of structural parameters (morphology, spatial distribution) of the individual components, while at the same time they mimic real catalysts closely enough to allow testing under industrially relevant conditions. Using this approach I will address fundamental questions, such as: * What are the mechanisms (structural, electronic, chemical) by which non-metal promoters influence the functionality of copper-based catalysts? * Which nanoalloys can be formed, how does their composition influence the surface active sites and catalytic functionality under reaction conditions? * Which size and interface effects occur, and how can we use them to tune the actitivity and selectivity towards desired products? Our 3D model catalysts will be assembled from ordered mesoporous silica and carbon support materials and Cu-based promoted and bimetallic nanoparticles. The combination with high resolution characterization and testing under realistic conditions allows detailed insight into the role of the different components; critical for the rational design of novel catalysts for a future more sustainable production of chemicals and fuels from renewable resources.


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Dec132019NOCOMMENTS
Ed on ITV's The Opening Show tomorrow!
I thought I would let you know that my son Ed will be on ITV Racing's The Opening Show on ITV4 from 9.30am tomorrow morning, to talk about his incredible season in pony racing both in the UK and Ireland.
We're all so proud of him and if you happen to have a quiet morning planned, hopefully you might be able to tune in!
Sandown success for Oriental Cross
A facile winner on her latest outing at Southwell in November, Oriental Cross made light of a 9lbs hike in the weights and the rise in class when scoring at Sandown Park yesterday under Alan Johns.
The six year old daughter of Cape Cross won a bumper as a four year old, but she is a big, strong mare and she has clearly done well for another summer at grass, this latest win coming off a career-high mark of 115.
Though it was a gruelling finish at the end of two and a half miles in heavy ground, she had travelled sweetly through the contest and I am confident there is a good bit of improvement left to come from her. There are a few possible races for her in early-mid January and we'll make a plan once her new mark is published on Tuesday. Congratulations to her owners John Durston and Nigel Harris!
Timely Gift doubles up at Market Rasen
Fresh from a confidence-boosting win at Plumpton three weeks ago, Timely Gift recorded a third career success from his 12 starts to date when winning at Market Rasen yesterday, though he needed to dig very deep to get the better of the runner-up in the shadows of the post.
He once again travelled nicely through the contest and looked the likelier winner at the last, but the runner-up rallied to regain the lead inside the final furlong and Alan had to be at his strongest to get Timely Gift's head in front on the line.
I am delighted for his owners, who have had to be very patient (he missed all of 2018 through injury) and have now been rewarded with two wins. Given the narrow margin of victory once again, I would imagine he will only get a 2-3lbs rise from the handicapper, so there is every reason to think he can make a very bold bid for the hat-trick next time. However, we may look to give him a little break first, with a view to returning to the racecourse in the spring.
We have a busy day ahead, with four runners up at Sedgefield, including Alltimegold, who will bid for a fifth win of the season in the opening handicap hurdle. We also have two 'Bells' runners at Exeter for owners Steve and Mick – good luck to all concerned!
Norwegian Woods off the mark
I couldn't be happier with how the horses have been going in recent weeks and Norwegian Woods became our 35th winner of the season when winning at Southwell yesterday under Alan Johns.
The six year old had fallen at Hereford on his previous outing, but had travelled well through the race before tiring that day and dropped back to 2m4f yesterday, he came right away from the field after the last to score by eight lengths for owners David & Susan Luke and The Lucky Strats!
Longer-term, he is very much one that will be seen to best effect over fences and I wouldn't rule out sending him chasing in the coming weeks, but we are likely to give him another run over hurdles first and hopefully this success will be the first of many.
Adherence scores again at Taunton
A winner at Taunton on his first start for us in March, Adherence retained his unbeaten record at the track when scoring over fences there yesterday under an excellent ride from Alan Johns.
Held up in rear, he was at the back of the seven-strong pack still in contention turning for home, but made good headway on entering the straight. He had the leader in his sights after the second-last and hit the front before the final fence, coming clear to win by over three lengths.
He has a few options for the remainder of the month, but the one that stands out, providing it doesn't come too quickly, is a 2m7f, 0-105 novice handicap chase back at Taunton on Thursday 12th December. Congratulations to his owners The Bill & Ben Partnership!
Barntown impresses at Lingfield Park
A new recruit to the yard earlier this year, Barntown has looked a nice horse in his work at home and would have most likely made a winning handicap debut at Lingfield Park last week, only to fall at the last. However, just a week later, he made amends in fine style back at the same course yesterday, winning a class 3 handicap hurdle under Alan Johns.
Held up in last, he once again travelled very strongly through the race and had the leader in his sights from the third last, with the rest well behind. Alan bided his time, but joined the eventual runner-up at the second last and picked up really well to come clear by just over two lengths.
A good-looking five year old with an excellent pedigree (his two half-brothers both have Racing Post Ratings in the 140s and have gained black-type this year), he looks a very progressive individual and I am looking forward to running him again in the coming weeks, as he looks the type to pick up a nice handicap in due course. Congratulations to his owners, The Pant Wilkin Partnership!
Timely Gift scores at Plumpton
Runner-up on his previous outing, Timely Gift went one better at Plumpton yesterday under Alan Johns, recording the second win of his career to date.
Travelling well throughout, he was sent to the front at the second-last and kept on resolutely to score narrowly. The margin of victory means the handicapper is unlikely to give him more than a couple of pounds and having shown improved form for the step up in trip, I am confident Timely Gift can make a very bold bid to follow up next time. Well done to his owners Carl, JJ, Chris, Mike, John and Hugh!
Oriental Cross wins in style!
On her second run back from a summer break, Oriental Cross recorded a career-best effort when scoring at Southwell yesterday under Alan Johns.
The form of her win at Newcastle in the spring had worked out well and we were confident she had come on for her recent reappearance, but with heavy ground an unknown it was still a pleasant surprise to see her travel so well through the race, finding plenty up the home straight to win very comfortably.
There is an option at Ffos Las next Friday where she could go under a penalty, but I doubt the handicapper will be overly severe and we will most likely give her a little longer before her next run. Congratulations to her owners John Durston and Nigel Harris!
Oct112019NOCOMMENTS
Vincent victorious on Exeter return
A dual winner over fences late last year, Cap St Vincent had been off since finishing third in his bid for a chasing hat-trick at Sandown Park last December, but he made light of the 10-month absence with an authoritative win on his seasonal bow at Exeter yesterday.
Alan Johns saved ground on the inside and the pair travelled strongly throughout. In what was an incident-packed race, they did well to avoid one that fell in front of them at the fourth-last, keeping on resolutely up the straight to score comfortably.
That was the first time he had gone beyond two miles since joining us and it does present more opportunities for him going forwards. We won't be in a rush, but will look for something early next month and will perhaps look to step him up in grade off a low weight. Congratulations to his owners Brian and Wayne Jones!
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Starting a business can be stressful and challenging. It requires your full attention and energy to implement. It all starts with an idea, an observation that there is a problem and the belief that you have a new solution or a better one to it.
We would be walking you through five basic steps to consider when you are starting your business.
Researching and finding about your new venture. You can learn a whole lot from a few hours of surfing the Internet and Googling. Do your homework properly and you'll be better off. It is a very necessary step to determine the viability of your business idea. In this process you must be honest with yourself, has your idea already been done before, now can you do it better or would you be offering it cheaper than your competition? Always ask yourself the hard questions and get feedback from associates and mentors.
The key to success is finding the needs that your business venture can fill, that you want to fill and that will produce enough income to build a profitable business. When going into a new business, you make sure that this is the business you are passionate about. To minimize your risk for loss, never assume there is a market. Talk to real potential prospects (who aren't family and friends) to find out if what you plan on selling is something they'd be interested in buying and if the answer is yes, what would they pay for the product.
Anyone who is serious about his or her startup must write a business plan and even though you may cringe at the thought of it, it can be very rewarding. First of all, write your ideas out, make notes on the products and services you would render. Describe the product, how you're planning to market and sell it; what is your pricing model; who is your competition and what is your expertise.
For you to be able to know your product, it comprises of two things basically: first is what is it made of and the second is what are the features and benefits?
In the aspect of what is it made of? You would need to know the components in every detail, what parts you have and also what tools do you need to purchase.
In the aspect of features and benefits, you need to understand everything about your service as it relates to your target audience. How do you deliver it? Is your price competitive? What makes your product unique? When you are done with this phase, you can then understand whom your customer is and how to communicate with your target market.
For starting a business you would need to plan your financials properly. If you want to raise funds it has to be more detailed and if you are going to startup the business by yourself or with a partner and you might be able to get away with a simpler set of projections.
These few steps would serve as an aid in starting your own business.


No good deed goes unpunished. The world has its share of heroic people who will risk their own lives to keep other people safe, but they don't always get parades and trophies for their good deeds.
In the name of bureaucracy, procedure, or just pure selfishness, some people get dragged through hell for trying to help others. Sometimes it's out of jealousy, sometimes it's for profit, and sometimes there's a whole system in place designed to keep people from being extraordinary. Whatever the reason, the way these good people were treated will make your blood boil.
Oliver Sipple wasn't a Secret Service agent or a bodyguard—he was just a bystander in a crowd. He'd come out to see Gerald Ford, never expecting for a moment that he'd end up saving the president's life.
But when a woman in the crowd pulled out a revolver and fired at President Ford, Sipple was the one who stopped her. He grabbed the assassin's arm, knocked the gun out of her hands, and saved Ford's life.
The media went into a frenzy. Sipple begged them not to put his name in the news, but it was too perfect a story to leave out of the papers. They reported everything that they could find about him.
Pretty soon, though, the papers were running out of new angles on the story. So when word got out that Sipple had been spotted in gay bars, they outed him on the front page.
It was actually Harvey Milk who leaked the story. He thought that outing Sipple would improve the public's image of homosexuals, but Sipple went through hell because of it. His family didn't know he was gay until they read it in the paper. When they found out, they ostracized him.
As his reward for his heroism, Sipple was left lonely and rejected by his family. He spiraled into depression and died an alcoholic at the young age of 47.
Tomas Lopez was on duty at Hallandale Beach, Florida, when someone rushed over to his post. A man had swum out too far, Lopez was told, and the victim was drowning. As any lifeguard would, Lopez rushed over and got the man to shore with the help of some other beachgoers. There, they gave the man CPR, called the paramedics, and saved his life.
When Lopez handed in the incident report, he was fired instead of being heralded as a hero. The drowning man, his company informed him, was "out of the protected area" and a clearly visible sign said that anyone who swam there did so at his own risk. According to company policy, anyone drowning outside the designated area was to be left to die.
Lopez's coworkers were infuriated. Six other lifeguards stood up for him, telling the company and the media that they would have done the exact same thing and that Lopez deserved an apology. So the company fired them, too.
Veronica Cherwinski had already lost one friend to heroin, and she was about to lose another. Her neighbor was lying on her couch, passed out from an overdose, and going through all the same symptoms Cherwinski had seen. She wasn't willing to lose another friend. So she called 911 and waited with the woman until rescue workers arrived.
Cherwinski's call saved her friend's life. But instead of thanking her, the officer who responded decided to bust her for drugs, too. He searched her home for heroin, arrested her on possession, and threw her in jail.
The arrest was illegal. The state had a law giving immunity from drug charges to anyone trying to save someone from an overdose. But the police sergeant defended his officer.
According to the sergeant, he tells his men that, when in doubt, they should "make the arrest and let the situation play out." The judge and the court-ordered defense lawyer didn't care enough to look into whether Cherwinski was protected.
The reporters at The Providence Journal decided to take up Cherwinski's cause. When the law wouldn't lift a finger to protect her, they proved that she couldn't be charged and got her released.
By then, though, it was too late. Cherwinski's drug tolerance had dropped in prison and nobody made any effort to help her change her lifestyle. Shortly after getting out, she injected again. Unaware that she couldn't handle the same doses anymore, she overdosed and died.
Arnold Abbott was working with two Christian ministers to feed the homeless outside of a Fort Lauderdale park when the police showed up. For feeding the homeless near a park, they told the 90-year-old man as they slapped handcuffs on him, he was going to be hit with a $500 fine and 60 days in jail.
Leon Walls's rampage started on the streets. Walls, a homeless man who was out of his mind, walked up to a group of men he'd never met and stabbed one on the street. Then he ran as fast as he could into a nearby Target.
The stabbed man and two of his friends rushed after Walls, trying to stop him before he could hurt anyone else. But by the time they found him, he was already holding a 16-year-old girl at knifepoint.
They tried to talk him down. But when Walls started stabbing the girl in the ribs, they jumped into action. One tackled Walls from behind while the girl's mother pulled her to safety and the other men took him down. The girl survived. But if those three men hadn't been there, she would have died.
Instead of praising them, though, Target sued them. In what may be a move to limit their liability, Target has declared that the men who stopped Walls are responsible for his actions because they chased him into the store.
Michael and Channel Keeley were arrested for doing the right thing. They had just learned that the tenants who were renting their home had been busted for meth possession. So the Keeleys went to the property to clean it up and put it back on the market. While there, they found that their ruined house had eight bags of meth hidden inside the walls.
The officer then arrested the couple for "tampering with evidence" because, apparently, finding evidence and immediately handing it over to the police is a form of tampering. They threw the couple in jail and threatened to send their nine-year-old son to child services.
After it became a media circus, the police dropped the charges. But the couple spent two days in prison, had to pay $5,000 each to post bail, and saw their son become traumatized by an officer of the law before that happened—all because they tried to do the right thing.
At 83, Beatrice Weisman was recovering from a serious stroke in Maryland General Hospital when she suffered a heart attack. The medical staff jumped into action. Without wasting a second, they used CPR and a defibrillator to get her heart back to normal and save her life. For a brief moment, they thought they were heroes—until Weisman's son sued them.
The hospital didn't realize that Weisman's husband had signed legal papers saying that his wife should be allowed to die if her heart failed. Beatrice and her husband had put advanced directives in place before any of this happened.
However, in their rush to save her life, the hospital staff didn't think to check if anyone had signed a legal form to let the patient die in such a case. The document was at the top of her chart.
Philosophically speaking, it's a tricky moral problem with no clear answer. Beatrice's end-of-life wishes were unintentionally disregarded by good people who saved her life. But her quality of life is not that of a healthy person. And this is not what she wanted. Absent a lawsuit, the hospital and the good people who saved her life also do not have to pay for her continuing cost of care. Without enough money, what would happen to Beatrice?
She sustained broken ribs and collapsed lungs from the efforts to save her life. When she was released from the hospital a few months later, she was bedridden and hooked up to a feeding tube and catheters. Her family paid out of pocket for 24/7 care and intensive physical therapy.
As a result, Beatrice is now able to live at home, eat meals, and go to church on Sundays. But she still needs 24-hour-a-day care and has dementia that leaves her frightened and confused. Her son says that Beatrice is suffering and that she wonders why she is still alive.
Ryan Snodgrass was working as a rafting guide in Clear Creek, Colorado, when he spotted a 13-year-old girl struggling to keep her head above the water. She'd been swimming for more than 30 minutes since her raft capsized, and the whole town was looking for her. Snodgrass, though, was the first to spot her, and he didn't want to waste one more second before saving her.
Snodgrass jumped in the water, grabbed hold of her, and saved her life. Then he let Sheriff Don Krueger know that he could call off the rescue team. The girl was safe.
When the story got out to the press, Krueger agreed to drop the charges—but only if he still got to look good. The only way he would drop the charges, he told Snodgrass, was if Snodgrass publicly apologized and told the world that Krueger was in the right.
So Snodgrass had to release a statement saying that he was sorry he'd saved a young girl's life. If he hadn't, he would have been thrown into jail.
In New York City, Dr. Pavel Yutsis was running tests on a patient who thought she might have a vitamin B12 deficiency when he found something troubling. There were signs that she might have HIV, he told her, and he wanted to run tests to find out for sure.
Dr. Yutsis was worried enough about her health that he ran the test anyway. When she came in for another checkup, he broke the news that she was HIV-positive. The diagnosis gave her time to get help. But instead of thanking him, she sued him for running the tests without permission.
Stories like these don't just affect one person. They can change the way a whole culture behaves. That's certainly what happened in China after a man named Peng Yu was sued for helping an old woman who'd fallen down.
Peng Yu saw Xu Shoulan fall as she was getting off a bus. He rushed over to help her, took her to the hospital, and handed her the money he had in his pocket to help pay her bills. But instead of thanking him, Xu Shoulan sued him, claiming he'd pushed her.
There was no evidence against Peng Yu. In fact, there were several witnesses who testified that he wasn't anywhere near Xu Shoulan when she fell. The judge, however, ruled that "no one would in good conscience help someone unless they felt guilty" and forced him to pay her the equivalent of $6,076.
It didn't just affect Peng Yu. Afterward, people across China were too terrified to help anyone who got hurt because there was a legal precedent that let injured people sue the people who helped them.
One of the worst stories came in 2011. A two-year-old girl was run over by a car while 18 people watched. But nobody moved a muscle to help her. Terrified that they'd be sued like Peng Yu, all 18 people walked away and left the child to die.
Surprisingly, sometimes it goes the other way. Read about amazingly good deeds done by bad people on 10 Amazingly Good Acts Performed By Bad People and 10 Surprising Good Deeds From History's Greatest Villains.


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Asheville is a city tucked away near the mountains of North Carolina. One of the attractions of the area is the Biltmore House, a large historic home available for touring. The home is beautifully decorated with trees and lights during the Christmas season and offers wine tours in the spring and summer. When you explore the grounds of the Biltmore House, you will be transported back in history as you tour untouched decorations and amenities have been left as they were when the home was first built.
The area is known for its unique restaurants and chefs. There are several festivals in Asheville that feature live music, dancing and even more food. Beer is also served at the festivals, and you can enjoy Asheville's vibrant nightlife and craft beers at local bars. There are numerous food tours throughout the city. BBQ is one of the things that the area is known for.
Nature lovers who move to Asheville will be enchanted by the natural forest beauty and rugged mountains. The Blue Ridge Parkway is located near the city. This is a road that stretches over 400 miles through the mountains. While on the parkway, you will see the beautiful colonial-era homes as well as the details of the towering rock formations. There are walking and sightseeing tours in Asheville that give you an up close look at the churches, historical buildings and businesses. Some of the tours are by bus while others are by trolley, making it easier to get on and off at some of the stops, such as the Thomas Wolfe Memorial. Other attractions include the Grovewood Gallery and Basilica of Saint Lawrence, the only Roman Catholic basilica in Western North Carolina.
When you contact our Asheville moving company, you will receive the best customer care possible. Allied Van Lines will help you with your packing and can even provide some of the materials that you need, such as boxes and tape. We can also provide temporary storage of your belongings, a service not offered by all moving companies in Asheville. Call today for a free quote.


This weekend in Berlin saw the last days of the festival of lights, as well as the last glorious days of Indian summer. All the usual weekend traditions were in place. People were sitting outdoors having brunch in the almost 20 degree weather for one last time. I had a leisurely stroll through the organic market on Kollwitz Platz. In the evening on Saturday the streets were packed on Unter den Linden as crowds of Berliners and tourists alike took advantage of the penultimate night of Berlin's most historic monuments illuminated with a beautiful display of lighting. Weekends in Berlin are always something special but this one seemed especially memorable as people flocked to the streets for one last bask in the almost summer like weather. This could especially be seen on Sunday with the masses of people at the flea market and outdoor Bearpit Karaoke at Mauerpark. Although no one is looking forward to the long grey months of winter ahead there is one more reason to rejoice coming up in one week. Next Sunday on the 28th of October the entire city of Berlin will celebrate the 775th birthday of the sister city of Berlin, Colln.
Although there were settlements in the area around what is now Museum Island and the Nikolai Quarter at least a hundred years earlier, the first mention we have of the city comes from a church document dating back to 1237. In 1307 the two cities came together and formed the city of Berlin. This will be the third times the city celebrates its founding. First in 1937 the Nazi celebrated the 700th anniversary of Berlin and then in 1987 the then still divided city celebrated its 750th birthday. All around the historic heart of Berlin info booths have been set up and labeled "Traces of the middle ages" (Spuren des Mittelalters). Directly across from the Berliner Dome on Schlossplatz (Palace Square) since August a map of Berlin has been created with 7 meter high multicolored pins sticking out of the ground marking the path of migration of various immigrant groups who have come through the city over the centuries. The best is yet to come however as the real celebration is on Sunday the 28th. In the best Berlin tradition the whole area will turn into a huge street party .
They have planned breathtaking fire shows including live music as well as the German theater group Titanick scheduled to put on an elaborate performance. Berlin is already a unique city in that drinking in public is allowed and next weekend is sure to be a cacophony of culture delights and boisterous merry making. In the words of Tom Mueller in the Smithsonian, Berlin is "a city still finding its identity and is a place of almost impossible contradictions: fixated with the past yet still impatiently pursuing the future, impoverished yet artistically rich, a former capital of dictatorship and repression that has become a homeland of social freedom." On Sunday the 28th Berlin will celebrate all her many facets. I hope to see you there.


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Brad Clark, vice president and head of Engine and Transmission Manufacturing FCA North America announces FCA's investment of $400 million to convert the ITP II plant into an engine assembly plant while also changing the name to Kokomo Engine Plant on March 5.
Tim_Bath
Attendees watch a video overview of the plant and what it will look like. The plant is currently being used for storage of transmissions only while the old equipment is being removed.
Photos by Tim Bath | Kokomo Tribune/
Mayor Tyler Moore, Gov. Eric Holcomb and COO of FCA NA Mark Stewart talk about the engine and the Jeep Rubicon that it is in.
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FCA leaders offer details on $400M revamping of transmission plant
Carson Gerber Kokomo Tribune
Carson Gerber
Say goodbye to Indiana Transmission Plant II. Say hello to the Kokomo Engine Plant.
That's what a crowd did Thursday afternoon inside the 600,000-square-foot facility on north Ind. 931, where leaders with Fiat Chrysler Automobiles publicly confirmed that the now-idle plant will begin making the Global Medium Engine Turbo 4 (GMET4).
The move marks a $400 million investment in the facility that will retain about 1,000 jobs and add nearly 200 more, bringing the total FCA employment in Indiana to over 8,300.
Now, the facility will be the source of all U.S. production of the engine, which is currently being built in Termoli, Italy. Production is expected to begin in the second quarter of 2021.
Brad Clark, vice president and head of engine and transmission manufacturing for FCA North America, said the plant had made nearly 4 million transmissions from 2003 to 2018, when the company began to shutter the facility. It sat idle for the last few months.
Mark Stewart, chief operating officer for FCA North America, said the plant served a long life building transmissions, but the company is now repurposing it for the next generation of engines. The facility will be called the Kokomo Engine Plant.
That engine is currently an option in the Jeep Wrangler and Cherokee, one of the company's most iconic brands. A 2020 Wrangler was on display inside the facility, its hood popped open showing off the GMET4 inside.
Stewart said that engine is one of FCA's most fuel efficient, but still offers 270 horsepower and 295 pounds of torque, along with low emissions.
"It's an amazing, amazing turbo-4 engine," he told the crowd. "It gives our customers the torque and the power that they love in our engine, and one that is super fuel efficient."
But the GMET4 will also play a pivotal part in expanding FCA's electric engine options, Stewart said, since a significant number of new technologies can be applied to it, making it relevant for future developments.
"It will play an important role in our plans to offer electric engine options across 30 nameplates that FCA will bring to markets around the world by 2022," he said.
The announcement and name change of the facility was attended by a horde of local and state officials, including Gov. Eric Holcomb.
Holcomb told the crowd that Indiana is grateful to FCA for choosing Kokomo to invest in the plant and bring new jobs to the state.
"To know that you chose to grow in Kokomo, it's a decision we'll never take for granted," he said. " ... You could have chosen anywhere, whether it was close to us or far away, and you chose to grow in Kokomo. We're extremely grateful.
"I'm a little biased, but I think it was the wisest decision you could have made," he added, getting a chuckle from the crowd.
Kokomo Mayor Tyler Moore also thanked the company for bringing production of the engine to the former transmission plant. He said the investment will be a boon for the area's economy.
"This is truly a great day not just for Fiat Chrysler, but for Kokomo and Howard County as a whole, but most especially for the local workforce that will benefit from this," he said. " ... The future success of Fiat Chrysler, like its past success, will continue to invigorate our economy and be felt by everyone."
The Kokomo Common Council helped attract the company's investment by approving a 10-year, step-down abatement, starting at 100% in the first year and lowering by 10% each subsequent year.
The local tax abatement joined a slew of other, state-level incentives offered to FCA, including incentives related to job training; performance-based tax credits hinged on whether the company hires Hoosiers; redevelopment credits meant to incentivize work on vacant property; and more.
Stewart said FCA was proud to work with local and state leaders to make the facility renovation work, and said the company felt good about investing in Kokomo.
"We're very excited – pun intended – to be an economic engine to help this community thrive and help the next generation and help all of us together as a family," he said.
But company and elected officials all agreed the investment was only possible because of the local workforce, which fought for the new engine line and proved they can make anything, and make it well.
Cindy Estrada, vice president and director of the FCA department for the United Auto Workers, said the local union membership was vital in the company's decision to invest in Kokomo.
"I've learned one thing in my time as vice president of the UAW, and that's one of the strongest memberships that we have, who fight for product and fight for workers' rights, is the Kokomo membership," she said " ... This wouldn't be possible without the quality they bring."
FCA Engine Vice President Clark agreed.
"Our employees have risen to every challenge that's been put in front of them, exceeding all expectations," he said. " ... This is a great day for Kokomo as we diversify our operations and bring additional opportunities to this region."
Carson Gerber can be reached at 765-854-6739, carson.gerber@kokomotribune.com or on Twitter @carsongerber1.
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Carson Gerber is a reporter for the Kokomo Tribune and can be reached at 765-854-6739, carson.gerber@kokomotribune.com or on Twitter @carsongerber1.
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5 minutes walk from Azabu-juban Station.
Unique sensitivity which weaves together the world view of both Japanese and western. Each and every season, we choose the best seasonal ingredients at the best timing.
Please make a reservation through website of Japan Finder!
※If you have special preference for food, please notify us upon reservation.
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Q: Node.js + Socket.io + Windows 10? Здраствуйте. Столкнулся впервые с node.js(установка и использование сокетов). Проблема в том,что при установке любого пакета типа npm install выдает одно и тоже предупреждение npm WARN notsup SKIPPING OPTIONAL DEPENDENCY: Unsupported platform for fsevents@1.1.2: wanted {"os":"darwin","arch":"any"} (current: {"os":"win32","arch":"x64"}). Понимаю что настройки системы не устраивают. Подскажите куда копать чтобы исправить. Или вся проблема в виндовсе в корне? Спасибо

A: Не поверите, но ничего делать не надо. Это опциональный пакет для работы со специфическими API  OS X. Он просто недоступен для Windows и это нормально (вот здесь есть похожий вопрос в гитхабе проекта).

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Movie Abyss Stephen Hawking and The Theory Of Everything
Stephen Hawking and The Theory Of Everything
Synopsis: Twenty years after A Brief History of Time flummoxed the world with its big numbers and black holes, its author, Stephen Hawking, concedes that the "ultimate theory" he'd believed to be imminent - which would conclusively explain the origins of life, the universe and everything - remains frustratingly elusive. Yet despite his failing health and the seeming impossibility of the task, Hawking is still devoted to his work; an extraordinary drive that's captured here in fleeting interview snippets and footage of the scientist sharing a microwave dinner with some fawning PhD students. Though the pop-science tutorials that dapple the first of this two-part biography are winningly perky, Hawking, alas, remains as tricky to fathom as his boggling quantum whatnots
Tagline: A mind-expanding view of the big picture
Production Companies: Discovery Channel Productions
A Brief History of Time
IMAX - Cosmic Voyage
Dating Fossils and Rocks
Der Lange Weg ans Licht
Death of an Angel
Examined Life
Hearts of Darkness: A Filmmaker's Apocalypse
The Ister
Mortal Thoughts


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The Explorer (Anomaly Quartet)
James Smythe has written scripts for a number of video games, and teaches creative writing in London. His previous novel was The Explorer.
"There have been teachers in space, senators, and the wealthy who buy tickets. But never has a journalist been launched over the atmosphere. Until Smythe's gripping novel." -- New York Post"The Explorer by James Smythe is quiet, dark book which focuses on the dark and quiet of space....It may not be a flashy...but it is a fascinating character study that could only exist in a science-fictional world." -- io9.com"Beautifully written, creepy as hell. The Explorer is as clever in its unravelling as it is breathlessly claustrophobic." -- Lauren Beukes, author of Zoo City"This is a remarkable book: a state-of-the-art spacecraft constructed from ideas, and propelled by a powerful story. Gripping, terrifying and audacious--an exploration in every sense of the word." -- Charles Yu, author of How to Live Safely in a Science Fictional Universe"Science fiction is best when it does what we least expect, when it transforms narrative into something you don't see coming....It's a trick not every writer can master, but Smythe makes a marvel of this world, and these characters, and makes this reader want the sequel now." -- Romantic Times BOOKclub (Top Pick!)"The Explorer is smart, scary and seductive. Like its protagonist, it explores the queasy strangeness of space-time, and puts the reader at the heart of a tale of watching and fearing that comes off like a collaboration between Hitchcock and Heinlein. Excellent stuff." -- Lloyd Shepherd, author of The English Monster"Dark, cold, claustrophobic, and oh so very scary. THE EXPLORER is literary science fiction at its blackest best." -- Adam Christopher, author of Empire State and Seven Wonders"The Explorer is essentially exemplary: a short, sharp shock of a story from an author who deserves to do as well for himself as he does by us. It's perfectly plotted, smartly characterised and rife with insight and excitement." -- Tor.com"A challenging and stimulating read." -- Booklist"A] mind-bending, heart-wrenching, avalanche of a reading experience... an oasis for readers thirsty to find an engaging book... books like this are the kind that create fans, and I'm proud to be one." -- SF Signal"The first person perspective and unpretentious prose style are enhanced by accomplished pacing." -- SFX (UK)"A brilliant book -- funny, desperate, desolate, sad, all in equal measure." -- Chuck Wendig"Unsettling." -- Daily Telegraph (London)"The Explorer has the dreamlike detachment of an Ishiguro novel.... reminiscent of a 1970s space movie, where the darkness of the void mirrors the darkness of the human soul." -- Financial Times"A wonderful examination of coping with loss, time and death." -- SFX"As if Philip K Dick and David Mitchell collaborated on an episode of The West Wing. Unsettling, gripping and hugely thought-provoking." -- FHM
Home » Books » Fiction & Literature » Science Fiction » General
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The Explorer Literature
The Explorer James Smythe
James Smythe Books


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Daily Freeman
Daily Freeman Homepage
Duncan D. Wilson
E B Gormley Funeral Home
WOODSTOCK-Duncan D. Wilson, 96, of Forest Dr. died Wednesday, September 29, 2021 at his residence. Born March 21, 1925 in Yonkers he was the son of the late Harry and Williamina Wilson. A veteran of World War II he served in the US Army and later was employed by IBM for many years. Active in the volunteer fire service he was a 64 year member of the Woodstock Fire Co. where he held every line office including Chief of the Woodstock Fire Co. He was the Ulster County Fire Coordinator, a member of the Ulster County Arson Task Force, the Ulster County Fire Advisory Board, past director of the Hudson Valley Fireman's Assoc., a member of FASNY, the UCVFA and a honorary member of the Saugerties Exempts Fireman's Association. Survivors include a son, Bruce (Cathleen) Wilson, seven grandchildren: Ryan, Heather, Natasha, John, JR, Vanessa, Rebekkah and a great grandchild, Dominque. He was predeceased by his children, Sheila Phelan and Robert Wilson and a brother, Harold Wilson and his first wife, Dolores and second, Faye. His Funeral Service will be held 11:00 AM Tuesday at the E.B. Gormley Funeral Home, 87 Main St., Phoenicia. Interment will follow with firematic honors in the Woodstock Cemetery. Friends will be received Monday 6-8:00 PM at the E. B. Gormley Funeral Home. You may share a special memory or condolence with the family at Duncan's Tribute Wall at GormleyFuneralHome.com.
Published by the Daily Freeman from Oct. 2 to Oct. 5, 2021.
E. B. Gormley Funeral Home
87 Main Street P.O.Box 97, Phoenicia, NY
Sponsored by dailyfreeman.com.
How do you know Duncan D. Wilson? (Optional)


Mandas Disney Blog: Wordless Wednesday!
Ok so this is cheating a little ... but I'm stuck in work with no access to my photos for today!
So I thought I would share this awesome offer from DisneyStore.co.uk that everyone should know about!
Love it Manda!! Don't work too hard! Happy Leap Year/Day!
Ooo, I wish this coupon was good here in the states - would love to use it to order the Leap Day shirt. I've really enjoyed looking through your blog (LOVE the Christopher Walken/Pooh cartoon below!).
Love it, I guess that means I can't use it.. Bummer Thanks for sharing Manda. Have a Magical Day..
I'ma sucker for a DisneyStore.com coupon! Gets me every time.
I already have my online shopping cart filled and ready to go for a good deal like this one. I love the Disney Store.


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Black History Month: An Educator's Dilemma
Daniel Beaton
Prime Minister Theresa May held a reception at Downing Street to celebrate Black History Month.
Black History Month in the UK is often accused of being a clichéd exercise. While teachers on this side of the Atlantic are increasingly moving away from topics like US civil rights to those of black Tudors and the Bristol bus boycott, there are still lots of questions about how we conceptualise and deliver our black history in Britain.
Black History Month as taught in the UK has something of a branding problem. Like the activist movement Black Lives Matter, it really does not do what it says on the tin. Black History Month is billed as a celebration of past black contributions to British society, but one resource pack supplied by Reklaw Education includes posters of recent black movers and shakers. As one of my students objected, "this really doesn't seem about history." While we are in some sense always living in history, what we are doing with Black History Month is as much a PR campaign for black folks as it is history per se.
How necessary you think such a PR campaign is depends on your view on how conspicuous black success is within our culture. At any rate, if images of successful contemporary black Britons are to adorn our classrooms, Black British Pride Month or, as David Olusoga suggested in 2015, Black Heroes Month might be just as fitting a title.
Once one realises that Black History Month is as much an exercise in social recognition as it is a dispassionate reckoning with a once neglected history—and this it makes no bones about—then what counts as its appropriate subject matter becomes a highly contentious question. As Olusoga has pointed out, the establishment line of promoting black first timers has taken precedence over the history of exploitation under slavery and colonial rule. In so far as the white British population are invested in a notion of British pride, any reference to the uglier side of Britain's history will be met with resistance. That is one reason why this concept of group belonging is problematic.
Things become even more complicated when we acknowledge that some black people are also tired of their history being framed in relation to systems of exploitation. Educator Funmilola Stewart writes in the Guardian, "We should also be teaching about all the positive aspects of black history." Quite right. But this presents something of a challenge: if we want to segue our black history with our British history we will not necessarily find things as positive as we might hope and certainly not as unifying—notwithstanding the triumphs along the way.
David Olusoga hopes that young minds can grapple with Britain's place in a global network of slavery and empire. Perhaps I was fortunate in my teachers, but as a child in the 90s, I studied the transatlantic slave trade. It remains a non-statutory but popular key stage 3 topic but with so many electives and such scant time allocated to history on the school timetable, it could easily get ignored. GCSE history seems the optimal forum to tackle such complex questions in terms of student maturity, but history is only an optional GCSE, so many students would miss out.
Either way, while I would support a drive to make the study of slavery and empire a statutory year 9 topic, I understand why some people may not be entirely sold on delivering David Olusoga's big but somewhat depressing themes during a Black History Month also charged with the task of racial uplift.
As Olusoga states, "This year, the attack line has been that Black History Month and black history itself is divisive. The same government that officially supports Black History Month has warned schools not to teach what it characterises as 'victim narratives' that are supposedly 'harmful to British society.'"
To make history subservient to ideology—the ideology of a Conservative government—is a worrying proposition. Yet to some degree Black History Month is already in the ideology game. Therefore, questions as to what attitudes such history inculcates are very much already on the table. David Olusoga is not worried by the idea that Black History Month could encourage divisiveness, but is it really such a stretch? In an age of renewed identity politics, young minds seem quite capable of developing deep resentment toward British society and white people in general. In his part-autobiographical, part-historical book Natives, public intellectual and musician Akala describes how this kind of psychology evolves, as the author is exposed—alongside everyday racism—to a pan-African education rich in themes of slavery and empire. Things have hopefully improved since Akala's upbringing in 1980s Camden, but anger—whether ultimately justified in today's generation—seems very much a live option. The weighing of historic truth and social harmony is a delicate task.
So where do we go from here? A black history that tries to probe deeper into the past, while taking a break from the depressing features of anti-black racism, might reasonably look beyond British shores to Africa. As the cradle of the diaspora, Africa has a fascinating history that is increasingly garnering attention in the west. Mansa Musa of the Mali empire, the ruins of great Zimbabwe and the Dahomey Amazons are iconic and fascinating topics.
However, moving away from an exclusive focus on black British history would not be without challenges of its own. First, it makes black history overly broad and potentially unwieldy. Second, it invites powerful questions about conceptualisation and branding. Parcelling a broad history under a racial heading is problematic. Why don't we study white history? is a question asked not just by reactionary white adults: it is a question I encounter from multiracial cohorts of learners every October. And indeed, when white history is just history, this enforces a normativity in which white history is subtly coded as the default and preferred mode—a process that in leftist spaces might be referred to as centring whiteness.
The concepts of race we are using to classify chunks of history are largely of eighteenth-century contrivance and by packaging our history in this way we risk doubling down on these racial categories. Labelling pre-eighteenth-century African history as black history also invites a charge of anachronism. Such history is the history of people who today would be racialized as black and that's what people mean when they call African history black history, but racecraft would have been a foreign concept to much of medieval Africa.
Thrusting modern schemas and the modern baggage of race relations into the past can lead to confusion in the classroom, even when studying periods in which racial concepts were ascendant. Some students' simplified racial schemas lure them into the crudest us vs. them thinking on this topic, as evidenced by two recent student questions: Why would whites sell guns to African kingdoms if whites and blacks were enemies?; and Why would Africans sell their brothers into slavery to whites? A good teacher knows how to answer these questions, but they provide a taste of the binary thinking that black and white classifications encourage.
In so far as black is a racial category, black history really does begin with sustained white contact—with the development of plantation economies in the New World and of scientific racism. But this is also when white history began. White history and black history are two sides of the same coin. To conceive of slavery and colonialism and civil right as quintessentially black history, as many students do, is to miss the point that these struggles involved two sides.
The history of slavery and colonialism is no more distinctly black history than it is white history. However, to brand the history of racialised exploitation in the Age of Discovery black and white history will not do either. Such a bifurcation masks the complexity of race relations and attributes too much conformity of thought and action to both racial groups, glossing over finer-grained ethnic distinctions and excluding other racial groups, whose histories intersect with the expanding machinery of European imperialism.
So, while deft educators should not fear the delivery of a rounded exploration of slavery and empire within their classrooms, organising around this as the core idea of Black History Month is problematic. Personally, I would be tempted to label the big themes of New World slavery, the European scramble for Africa and the subsequent struggles of the diaspora as something more like the history of racial exploitation, resistance and reconciliation. That doesn't seem likely to replace Black History Month or cover all of Black History Month's bases, but so long as such a field of study is embedded in our broader history curriculum, alongside a history of the kingdoms and empires of sub-Saharan Africa, Black History Month would find itself increasingly without a rationale—and what an achievement that would be.
Black British
Daniel Beaton is the Critical Thinking Instructor for Humanist Global Charity.
ericbergerud
Voting for Biden is impossible for me – out of the question. Let's put aside Biden himself for a second. Biden's election would vindicate an attempted coup launched against Trump by the highest officials of the Obama administration, including the heads of more or less all of the American intelligence apparatus. All of the data that has come in on this matter in the last year and a half make the situation look more disturbing than ever. Second, you'd have to be nuts not to think that Biden's people were intentionally quiet during the urban chaos between May and September. They were watching Democratic mayors and governors more or less allow anarchy – including the shooting deaths of over 30 observers. When Biden started showing a drop in the polls in September, quiet descends outside of black hole in Portland. Third, the press has utterly abandoned any role of informing… Read more »


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