There's a lot happening at the moment….if you happen to pop in this week you might see a costume fitting for the film I'm costuming "Only the Young Die Good". Here are some pics from previous fittings – I love costuming and it turns out, it's much easier when you have a vintage clothing shop to play with. Click on each image to see in full.
How beautifully do they go with Circa's new webdesign? Sue from Red Pepper Graphics has redone both the blog and webshop design – if you're reading this by email subscription, I recommend that you click here to see what I'm talking about. Thanks Sue – I love it!
This Thursday I'm giving a talk on vintage clothing at St Kilda library – it's booked out but if you'd like to go, there are still places available in next month's talk at Ashburton Library. That will be my last library talk for the year, although there are still spots available at my talk at Circa on how to accessorise an outfit vintage style. I'm also available for talks if you'd like to book me, I can talk about many aspects of fashion, fabrics and history.
On Thursday, Leonard Joel's are auctioning a vintage clothing collection from Sandy Bizy's Sydney shop – you can see the catalogue here. I was fortunate enough to go inspect it all recently and can confirm that there are some lovely fashions, in particular, I love this green two piece 1960s ensemble: fitted dress with sheer cape. Yum!
Speaking of Leonard Joel's, assisting me as I went through Sandy's collection was Claudia, my latest work experience student. Circa is now available for work experience for high school or tertiary students, by arrangement – if you're interested, please let me know and we can talk dates. You'll basically be my assistant for the week and help me in all my duties, including retail, admin, webshop and displays as well as anything else that happens: Claudia also came on a field trip as we visited a clock repairer, who was restoring Circa's 1910 mantle clock.
This year Circa is again supporting Miss PinUp Australia – last weekend I went to Hobart for the Tasmanian final and popped in to the amazing Museum of Old and New Art: blog posts on both will be coming soon, as will a contest to win tickets to the Way We Wear Fair in Williamstown next month. There's never enough hours in the day!
Also coming up, Rock 'n' Roll Shindig, at the Whitehorse Club on November 26th, featuring Phil Haley and his Comments – I saw them play last year at Wintersun and they put on a great show. Joining them are Out for the Count, a ten piece swing band so there's something for everyone who likes to dance. Tickets are selling out quickly – book here.
Last, but not least – this Sunday Walk-in Wardrobe are hosting a fashion fundraiser to raise funds for the Clown Doctors: a mini market of vintage clothes, accessories and footwear. Sunday October 30th 11-2pm at Boda Haircutters, 103 Greville Street Prahran. More information available at Facebook.


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Is Donald Trump killing his hotel business?
Trump Tower in the heart of Manhattan, New York Credit: Getty
Hugh Morris, Travel writer
20 May 2016 • 2:46pm
Hugh Morris
It's becoming increasingly difficult to remember that Donald Trump was in fact of woman born in the 1940s and has since enjoyed a full life of love, laughter and gainful employment, and wasn't, as some seem to presume, sent to us in 69-year-old, savannah-haired form by Kang and Kodos to bring the planet Earth to its knees.
The point is that Trump is more than the political sawn-off that 2015/16 has shown him to be. He is a property magnate and owner of a hotel and golf course empire that stretches around the world, from Chicago to County Clare, New York to Waikiki, with Rio, Vancouver and Washington all in the pipeline.
However, it looks like his drive to become leader of the free world is doing his hospitality operation more harm than good.
Donald Trump Hotels Golf resorts
According to a survey of more than 2,000 Americans by travel website Skift, more than half (56.9 per cent) said they were less likely to stay in one of Trump's hotels thanks to his presidential campaign.
On the flip side, nearly a quarter (23.4 per cent) said they were more likely to stay in one of his hotels because of his xenophobic, misogynistic crusade. The remainder were unaware he even had any hotels – not even the flagship Trump Tower in New York, which our reviewer gave a rating of 9/10 and said offers "no half measures".
Best hotels in the world
The poll found that women were more likely than men to avoid his establishments, which include the 24-carot gold-gilded Trump Hotel Las Vegas, and men more likely than women to have an increased desire to stay the night.
This is not the first suggestion that Trump hotels might face a struggle filling their rooms now that Trump has his eyes on the White House.
After he called for a blanket ban on Muslims entering the US, it was reported that Khlalaf Al Habtoor, a self-made billionaire whose UAE-based conglomerate built Dubai's airport, renounced his backing of Trump.
Indeed Lucy Lawless, the actress who played Xena Warrior Princess, said at the same time that she used to stay in Trump hotels but would "never again" and called for other to join her boycott.
In February this year, Bloomberg reported that a variety of Trump's ventures around the world were unsuccessfully weathering a range of storms, from disappointing returns, unhappy business partners, and unpopular branding.
Trump Tower Las Vegas Credit: Getty
Closer to home, Trump's reputation in Scotland, Aberdeenshire, to be precise, where the magnate built a controversial golf course is pretty much at rock bottom. Alex Salmond said of Trump: "What we were promised was billions of dollars and thousands of jobs. [Trump is] not in the sane spectrum."
Trump's rise to infamy has also prompted Lastminute.com, the travel booking website, to offer refunds to any guests who book a room in a hotel, but then discovers that the Republican in also staying there at the same time.
A photo posted by Trump Hotel Chicago (@trumpchicago) on Apr 19, 2016 at 7:54pm PDT
"Our primary goal is to ensure that our customers have the option of a quick exit to more tranquil Trump-free surroundings if they wish so," a spokesperson said.
A poll taken by Telegraph Travel found that 50 per cent of readers would not wish to stay in the same building as the man. Almost a third said they would - but as long as he picked up the bill.
Donald Trump - in numbers
That Trump has plans to open five properties in Muslim-majority countries, including Dubai, Bali and Azerbaijan, does not necessarily bode well for business, if he maintains a position not entirely favourable to Muslims.
It remains to be seen whether Trump's hotel business will collapse in on itself whether he wins or loses the presidential race, but with a good six months to go before the election, we can bet he'll say plenty of offensive things that may well tip the scale.
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Internal Revenue Code (IRC) section 401(a)(17) and IRS guidance issued under that Code section provide limits on the amount of compensation that may be considered under a tax-qualified plan for purposes of determining monthly benefits under the plan and contributions made to the plan.
For 2019, the compensation limit is $280,000. For 2018, the limit was $275,000.


My Way is a 95 foot motor yacht built by Admiral in 1994. She has had a refit in 2009 and again in 2014 to keep her elegant and luxurious for her guests. Twin 2300 hp MTU engines afford her a cruising speed of 23 knots and an impressive top end speed of 32. With her home port of Athens, she offers her guests luxury charters in the amazing waters of Greece and Turkey.
Four cabins offer comfortable accommodations for as many as eight guests. Her full beam master cabin offers a queen bed, desk/vanity, and en-suite facilities. The V.I.P. cabin features a queen bed, settees, and en-suite. Additionally there are two cabins each with two twin beds and en-suite facilities.
Her main salon features an exceptionally long couch for a yacht of this size with built in coffee occasional tables, along with two coffee tables and a bar. Al fresco dining is offered on both the aft deck and on the sun deck. Up on the bow there is a couch facing forward giving guests a remarkable view.
Watersports offered by My Way include a Cosmonautica tender with 50 hp engine, water skis, jet ski, tube, snorkeling gear, and rendezvous diving.
Please contact one of our yacht charter professionals to learn more about the motor yacht My Way.


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Dart's SOLO brand congratulates 2020 recipient of college football's premier community service award
Dart and our SOLO brand congratulate University of New Mexico offensive lineman Teton Saltes on his selection as the 2020 recipient of The Wuerffel Trophy – college football's premier award for community service.
New Grant Program to Protect Marine & Inland Waterways
Marinas and local governments across the US and Canada can stop litter from entering coastal and inland waterways and reduce marine debris thanks to a new grant program sponsored by Dart Container Corporation and UltraTech International, Inc. Dart will provide up to $100,000 in grants for the purchase and installation of UltraTech's patented Ultra-Drain Guard stormwater management products, which prevent litter, oil and sediment from entering waterways via storm drains.
Dart Container Supports Medical Community with PPE Production, Donations
Mason, MI – Dart Container, a major manufacturer of food & beverage packaging, is marshaling its expertise, equipment and people to help fill the dire need for personal protective equipment by health professionals battling the coronavirus.
Leola Facility Donates Materials for Face Shield Production
Leola, PA – Dart Container Corporation is taking raw materials usually used to make clear plastic cups and donating them to the production of much-needed personal protective equipment for the medical community.
Dart Container Identified as Essential Critical Infrastructure for COVID-19 Pandemic
Mason, MI - The US Department of Homeland Security has identified the food & beverage packaging industry as "essential critical infrastructure" during the COVID-19 pandemic. Therefore, all Dart facilities remain open at this time.
Dart congratulates 2019 recipient of college football's premier community service award
Dart congratulates Western Michigan University quarterback Jon Wassink on his selection as the 2019 recipient of The Wuerffel Trophy—college football's premier award for community service.
Dart Container unveils onsite health center for Horse Cave employees
HORSE CAVE, KY, June 27, 2019 – Representatives from Dart Container cut the ribbon on a new onsite health center today to increase access to primary care for employees and their families. Dart employs nearly 1,500 people at the Horse Cave facility. The health center—called MyCare Wellness Center—is available only to Dart Container employees and their dependents age 2 and above who are covered by a company medical plan. It will be open to patients beginning July 9.
Dart offers a video sneak peek at its new Mason Campus Technical Innovation Center
Mason, Michigan – Take a sneak peek at Dart's new technical innovation center! Slated to open this spring, the 260,000 square-foot facility will house Dart's Research and Development and Engineering teams under one roof to enhance customer engagement and expand the company's new product development and prototyping capabilities. This will be the first time the teams, which are currently in separate facilities, will work in a space specifically designed to facilitate innovation, collaboration and design.
Dart Congratulates 2018 Wuerffel Trophy Recipient Drue Tranquill
MASON, MI – Dart Container Corporation congratulates University of Notre Dame linebacker Drue Tranquill on his selection as the 2018 recipient of The Wuerffel Trophy – college football's premier award for community service.
Iconic Anthora™ Cup Featured on NYC's 2018 Bike Map
NYC Pays Homage to the Original NYC Coffee Cup May 23, 2018, New York City, NY – The original Anthora™ cup – the on-the-go coffee cup that came to symbolize New York's active lifestyle – is now beckoning bicycles to hit NYC's streets, bike lanes and trails. The paper cup The New York Times once called "perhaps the most successful cup in history" is making a special appearance on the cover of the New York City Department of Transportation 2018 NYC Bike Map.
Dart Congratulates 2017 Wuerffel Trophy Recipient Courtney Love
MASON, MI – Dart Container Corporation congratulates University of Kentucky linebacker Courtney Love on his selection as the 2017 recipient of The Wuerffel Trophy – college football's premier award for community service.
Three finalists named for college football's Wuerffel Trophy
MASON, MI – The Wuerffel Trophy – college football's premier award for community service – this week announced the three finalists for the 2017 award, which is sponsored by Dart Container Corporation's Solo brand of products for the second straight year.
Dart Donates Product to Hurricane Harvey Relief Efforts and Prepares for Hurricane Irma
Mason, Mich. – Dart Container Corporation's ongoing in-kind donation relationship with the American Red Cross has ensured a steady supply of cups for ongoing Hurricane Harvey disaster relief efforts.
Dart Container sponsors college football's Wuerffel Trophy to support service, academics
(Mason, MI) With the arrival of the college football season, Dart Container Corporation's Solo brand of products is proud to sponsor the Wuerffel Trophy and support the award's focus on community service and academic success along with athletic achievement.
Dart investing $40 million and adding 136 jobs in Mid-Michigan
(Mason, MI) - Dart Container Corporation in Mason, MI, is continuing recent campus expansion that has included the addition of a new corporate office facility and warehouse. The latest $40 million investment includes construction of a new technical and innovation center and expanded machine manufacturing operation.
Dart Recognized by AF&PA for Sustainability Initiative
Dart Container was recognized with the Leadership in Sustainability Award – Paper Recovery for Recycling.
Dart Container Opens Free, Foam Recycling Drop-Off in Thomaston
(Thomaston, GA) – Facility accepts used foam cups, foam egg cartons, foam packaging from electronics and much more
Healthcare improvement alliance recognizes Dart as superior supplier
(Charlotte, NC) - Dart has demonstrated our commitment to setting the Industry Standard of Excellence by earning the Supplier Legacy Award from Premier Inc., a healthcare performance improvement alliance based in Charlotte, North Carolina.
Dart Container Opens Free Foam Recycling Drop-Off in Chicago
Dart Container Corporation today announced the opening of a new foam drop-off center in Chicago. The center – which is publicly accessible 24 hours a day, seven days a week and is completely free of charge.
Dart Container Volunteers In Annual Great LA River Clean-Up
On Saturday, April 16, employees, friends and family from Dart Container's Corona facility joined thousands of volunteers in cleaning-up litter and debris from the Los Angeles River as part of the 27th Annual Great LA River Clean-Up, hosted by the Friends of the LA River (FoLAR).
Foam Recycling Coalition to offer polystyrene recycling grants
There has been an ongoing, heated debate over whether Styrofoam can be fully recycled. More than 100 municipalities say it can't be, while The Restaurant Action Alliance, Dart Container Corp., and many other municipalities say it can. At the least, there is very limited infrastructure to process this material. FRC is trying to change that.
2015 Anacostia Watershed Litter Survey
In October and November 2014, Environmental Resources Planning, LLC conducted a comprehensive litter survey of the Anacostia Watershed, which encompassed certain portions of the District of Columbia (DC) as well as Montgomery and Prince George's Counties in Maryland. The purpose of this survey was to gauge the amount and composition of litter along roadways and in non-roadway sites in and/or adjacent to waterways identified by Anacostia Watershed Society as indicator streams.
2015 Celebration of Regional Growth Awards - Dart Container Corporation
Dart thanks the Lansing Regional Chamber of Commerce for recognizing our continued commitment and growth in mid-Michigan!
UC Davis' Green Move-In Recycling Drive Tradition Continues for Sixth Year
Recently, the University of California, Davis, partnered with Dart Container Corporation for a foam packaging recycling drive. Often mistakenly referred to as Styrofoam, a trademark of Dow, the material is widely used to package many items that students bring to school including televisions and other electronics. The effort resulted in half a truckload being collected. The event was the school's sixth annual recycling drive and took place as freshmen students moved in for the school year.
New York State Supreme Court Overturns City's Ban on Foam
The New York State Supreme Court today overturned Sanitation Commissioner Kathryn Garcia's decision to ban foam foodservice items, clearing the way for the City to embrace a recycling program that would cover 100 percent of polystyrene products and generate new revenue for the City.
Dart Container Returns to Great American River Clean Up For Eighth Year of Foam Cup and Foam Packaging Recycling
For the eighth consecutive year, Dart Container is bringing foam (often mistakenly referred to as "Styrofoam," a registered trademark of Dow Chemical) recycling, education and volunteer efforts to the Great American River Clean Up. Last year, over 1,500 volunteers removed more than 21,000 pounds of trash and debris.
NYC provides businesses a foam grace period and hardship waiver
Good News in NYC! NYC has announced a "grace period" lasting from July 1, 2015 until January 1, 2016 during which they will NOT issue fines or penalties for business that use foam foodservice containers. Also, nonprofits and small businesses (not part of a chain) with less than $500,000 in revenue per year may apply for hardship exemptions from the Department of Small Business Services (SBS) if they can prove that the purchase of alternative products not composed of EPS would create undue financial hardship.
Solo/Dart Enterprise Announces New Name: Dart Products Europe Ltd.
Dart's European facilities previously operated under the names Dart Products Limited in Cradley Heath, West Midlands; and Solo Cup Europe Limited in Huntingdon, Cambridgeshire.
Dart Container Volunteers To Cleanup Los Angeles River
For sixth year, Dart employees joined thousands for the Great Los Angeles River CleanUp
Dart Container Files Lawsuit Against the NYC Foam Ban
(New York, NY) – Dart Container Corporation joined with the Restaurant Action Alliance NYC, members of the recycling industry, and the City's restaurant owners today in filing a lawsuit seeking to overturn the City's ban on foam foodservice items. Mayor Bill de Blasio, the New York City Department of Sanitation, and DSNY Commissioner Kathryn Garcia are named as respondents in the petition, which was filed against the Commissioner's erroneous determination that foam cannot be recycled. The determination flagrantly violated Local Law 142 as well as sound environmental and economic policy and plain common sense.
City businesses take fight against polystyrene foam container ban to court
A coalition including the Restaurant Action Alliance and Dart Container Corp. contends the ban Mayor de Blasio wants to start July 1 is illegal because the law requires the city to recycle such products, but Sanitation Commissioner Kathryn Garcia ruled arbitrarily that soft foam containers cannot be recycled.
Styrofoam proponents call NYC ban a 'sham'
Styrofoam proponents filed a lawsuit claiming that Mayor de Blasio's ban of their product is a "sham" — and that he only went through with it to keep his campaign promises and not because it can't be recycled.
Dart Container continues its commitment to keeping Michigan's highways clean
For the fifth consecutive year, Dart is participating in Michigan's Adopt-A-Highway program Mason, Michigan – Dart Container has announced that through their participation in Michigan's Adopt-A-Highway program, enough litter to fill 64 trash bags has been cleaned from Michigan's Highway 127. Dart volunteers, including employees, friends, and family donated their time to this very important cause.
The Foam Fight
The future of polystyrene recycling looks great! Check out the latest article on the current state of polystyrene recycling from Scrap Magazine.
New York City Chooses Landfilling Over Recycling
Despite acknowledging foam and #6 rigid plastics can be successfully collected curbside, the City turned down an offer to recycle tons of foam #6.
2014 Keep Georgia Beautiful Award Winners Celebrated
Atlanta, GA – More than 200 Georgians attended the 36th Annual Keep Georgia Beautiful Awards Luncheon on Friday, December 12 at the Marriott Century Center. The annual program honors individuals and organizations working to improve Georgia's environment.
Dart Employees Help Keep Georgia Beautiful With Recycling Drive
Conyers, Georgia (November 15, 2014) — America Recycles Day celebrates plastic, paper and foam recycling, but also more unique recycling like textiles and shoes. In honor of the holiday, Dart Container employees in Conyers, GA partnered with Keep Georgia Beautiful to help recycle shoes for men, women and children around the world.
Dart Container Remains Committed To Keep Our Rivers Clean
SACRAMENTO, CA – For the seventh consecutive year, with the help of Dart Container's Lodi manufacturing facility employees, friends and family, volunteers collected 21,000 pounds of litter from the American River Parkway during the Annual Great American River Clean Up.
Dart Cup Ltd./Solo Cup Canada Inc. Now Marketing Under a New Name: Dart Canada
Toronto, Ont. — Canada's leading manufacturer of single-use foodservice packaging has unified its activities and facilities (Dart Cup Ltd. in Campbellford and Solo Cup Canada Inc. in Toronto and Mississauga) under one name: Dart Canada.
Dart Container Corporation Moves Forward With Record Expansion
Dart Container is finishing construction on two new buildings that are part of the Mason company's largest local expansion. After more than 50 years of business in Mason, it's a change the company was ready for. "It obviously helps to have the space you need for the employees that are required for this operation," said Executive Vice President of Manufacturing at Dart, Dan Calkins.
Plastic Recycling, Inc. (PRI) announced today the launch of a new EPS recycling facility in Indianapolis, IN
Indianapolis, IN — Plastic Recycling, Inc. (PRI) announced today the launch of a new recycling facility in Indianapolis, IN dedicated specifically to the recycling of post-consumer foam cups, foam take-out containers and other used polystyrene materials collected through curbside pick-up programs across the country.
Dart Container Continues Commitment to Environment, Participates in 25th Annual Great LA River Cleanup
Dozens of Dart Container employees participated over the weekend in the 25th Annual Great LA River Cleanup event, hosted by the Friends of the LA River (FoLAR), donating volunteers as well as foam recycling education for the sixth year.
Dart Container Corporation Continues Commitment to Keeping Michigan's Highways Clean
Mason, Michigan — Dart Container announced the collection of 72 bags of litter this weekend, that have been cleaned from the Michigan highway with the help of nearly 25 employees, friends and family as part of the company's fourth annual participation in the Michigan's Adopt-A-Highway program.
Dart Container to Invest $14 Million in Plant City Expansion
Plant City, FL — Dart Container Corporation, the world's largest manufacturer of foam cups, has announced plans to expand its existing presence in eastern Hillsborough County with the construction of a 400,000 square foot warehouse in Plant City. Dart is investing $14 million in the project, and up to two dozen new jobs are expected to result from the expansion.
Dart Container Recognized for Community Impact
Mason, MI — Dart's commitment to Mid-Michigan was recently recognized on both local and national fronts. Dart joined the likes of Apple Inc., Amazon.com, Inc., Oberto Brands and other large companies recognized by Trade and Industry Development Magazine for bringing jobs to local areas. The Mason Chamber of Commerce also saluted Dart Container for their efforts in the community.
Community Celebrates Renewable Energy Project That Will Transform Municipal Landfills to Usable Energy Benefiting Residents
Leola, PA — Dart Container today was joined by city and community leaders for a ribbon cutting ceremony to celebrate Dart's landfill gas to energy cogeneration project. The initiative enables Dart to use gas recovered from Lanchester and Conestoga municipal landfills as a source of renewable energy to produce electricity, boiler fuel and steam.
Dart Container to invest $47 million, create 325 jobs in Mid-Michigan
Lansing, MI — The Michigan Economic Development Corporation today announced Michigan Strategic Fund approval of a $3 million Michigan Business Development Program performance-based grant for the expansion of Dart Container Corporation's operations in Mason. The expansion will generate up to $47 million in new private investment and add a projected 325 new jobs.
Highland Park City Leaders Announce Foam Recycling Success
Highland Park, Illinois — Highland Park city leaders today were joined by local partners to announce the results of community foam collection efforts. Since the program launched in 2011, the Highland Park community has dropped off foam products at the city's collection site resulting in over 4,417 pounds of foam collected and recycled.
Product Donation Helps Red Cross Relief Efforts
Dart Container Corporation is pleased that its 2012 donation of five million disposable cups to the American Red Cross is supporting disaster services such as the Hurricane Sandy relief efforts. DCC announced its second five-year product donation commitment to the ARC in January. "The free foam cups we provide not only help to lower the Red Cross's operational costs, but, most importantly, allow Red Cross staff and volunteers to efficiently provide cold and hot beverages to disaster victims and blood donors," said Jim Lammers, DCC's Executive Vice President of Administration and General Counsel.
Computers, Not Candy: The Geek Group Donates 100 laptops to High School Students
Grand Rapids, Michigan — On Halloween, as part of The Geek Group's (TGG) 'Computers, not Candy' program, TGG donated 100 re-purposed laptops to economically disadvantaged students enrolled in the Grand Rapids Area Pre-college Engineering Program/Engineering and Biomedical School. These students specifically enrolled in the program because of their passion for Science, Technology, Engineering and Math (STEM), making them perfect candidates for the laptops.
Dart Container Returns to Great American River Clean Up with Fifth Year of Foam Cup and Foam Packaging Recycling
Sacramento, Calif. — For the fifth consecutive year, Dart Container is bringing foam recycling (often mistakenly referred to as "Styrofoam", a registered trademark of Dow Chemical), education, and volunteer efforts to the Great American River Clean Up. Last year, over 2,200 volunteers removed more than 15,000 pounds of trash and debris in just three hours.
Dart Container Honored for Operational Excellence
Mason, Michigan — The Premier healthcare alliance has named Dart Container as a winner of the seventh annual Performance Award, which recognizes the efforts of contracted suppliers to meet and exceed operational expectations. In selecting recipients, performance data is collected and scored over four successive calendar quarters.
Dart Container Closes on Acquisition of Solo Cup Company
Mason, Michigan — Dart Container has completed its acquisition of Solo Cup Company, headquartered in Lake Forest, IL. Solo, which is now part of the Dart Container organization, manufactures quality single-use foodservice products. Dart expects to continue offering products under the Solo brand — including the iconic red Solo cup.
U.S. Foodservice Container Company Acquires Brazil Production Facility
Pindamonhangaba, Sao Paulo — Michigan-based Dart Container Corporation, the world's largest manufacturer of foam cups, has acquired Brasbar Disposable Packaging Ltd., a manufacturer of single use foam foodservice products. Brasbar, which has approximately 100 employees, is located in Pindamonhangaba, in the state of Sao Paulo midway between Rio de Janeiro and the city of Sao Paulo.
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How to Prevent Machine Learning Models from Failing in Practice?
By Kavita Ganesan / AI Project Management / April 2, 2021 June 22, 2021
Have you seen machine learning solutions fall flat in practice?
Well, I have. Several times. I get occasional panic calls from teams about their 98% accurate models generating questionable predictions once released to actual users.
Did they build a bad model? Maybe.
But the real issue is that the majority of these teams skipped a step.
And that step is testing. Not just any type of testing, but post-development testing (PDT).
What is Post-Development Testing (PDT)?
Post-development testing in the context of machine learning is an experimentation period where you take a model from development and test it on real data, and often with real users. And this happens before model deployment.
Post-development testing happens after model development and before full model deployment
Why is PDT Important?
PDT is important for two primary reasons. First, for ensuring that the model is working as expected in practice (model success). And next, to verify if the model is serving the needs of the business (business success).
Model Success
Let's first talk about model success. When models go from development to production (i.e., practice), there's often a natural degradation in performance. However, if the performance discrepancy is too wide, then it's no longer a natural degradation. It's a problem that needs to be addressed.
Let's say you're dealing with a fraud detection model. In development, say its accuracy is at 97%. But when you put the model to test on real data, you see that the model is making all sorts of mistakes and is only performing at about 50% accuracy. From a business standpoint, this performance is unacceptable.
There can be many reasons for a wide discrepancy between development performance (DevPerform) and production performance (ProdPerform). Perhaps there are many missing values, which the model does not expect. Or the real data comes from a different distribution than the training data. It could also be that the model has memorized exact patterns from the data it was shown. And when it sees a new unfamiliar pattern from the real world, it doesn't recognize it and makes an incorrect prediction. In technical terms, this problem is known as overfitting.
Such problems can be discovered during PDT. Instead of assuming that the model is going to work out-of-the-box, PDT allows you to validate this. And if it's not working as expected you still have a chance to fix it before it's released more widely.
A machine learning model exists to serve a business purpose. Whether it's to automate a workflow, improve productivity or reduce human errors—there is a purpose. Making progress towards this purpose is what business success is about.
The experimentation period during PDT allows you to verify that your business objectives are also being met. Even if it's not a hundred percent there yet, PDT gives you a chance to see if things are moving in the right direction from a business objective perspective.
Let's say the fraud detection model discussed earlier was meant to make customer support agents more productive. But it isn't—even after all model issues have been fixed.
Perhaps the user interface is problematic. Or, the network latency is preventing agents from consuming the results in a timely fashion. All of this can impact your decision whether to pour money and resources into operationalizing the model or not.
Getting Started With Post Development Testing
If you've never considered PDT in your AI initiatives, here are four tips for getting started:
#1: Test early
Don't wait for a perfect model. As long as the DevPerform is reasonable, you can put models to the test and start real-world evaluation. If you wait too long, you risk discovering issues that can set you back weeks and months. For example, say your development team has made the wrong assumptions about the input data. If this happens, no matter how perfect the model is, it would still require significant rework.
#2: Use the right ProdPerform metrics
Although your development team may have development metrics established, what you'd use in a production setting can be completely different.
For example, when it comes to a product recommendation problem, you may use precision and recall to assess DevPerform. But the same metric may not be applicable in a production setting due to the dynamic nature of the recommendations.
Example of dynamic book recommendations on Amazon
So, what can you do?
One option is to track click-throughs in production to see if users are engaging with the recommendations.
A click can be an implicit way of assessing relevance. Alternatively, if your budget allows for it, you can also conduct a user study. With this, you would recruit users to rate the recommendations on a rating scale. Say you assign a scale of 1-5, where the higher the rating, the more relevant the recommendation. This turns a subjective human assessment into something quantifiable.
You can get super creative with how you evaluate your ProdPerform. But always remember, part of it should be something you can track with time and spot deterioration.
#3: Use multi-faceted evaluation
PDT is not just to assess model performance. It's also a time to evaluate the relevant business metrics.
Ensure that the right business metrics are established and being tracked alongside metrics used for ProdPerform. If you don't see model issues, are your business metrics moving in the right direction? If not, this is the time to figure out why and resolve underlying issues. Or decide if you should go back to the drawing board.
#4: Iterate and re-evaluate
As problems are discovered during PDT, you need to fix the underlying problems and re-evaluate until a certain level of accuracy, business metrics improvement, or user satisfaction is reached. Once you've reached a point of diminishing returns, or when you feel that the results are good enough for practical use, then it's time for full deployment.
Have you tried PDT?
Looking back at your AI initiatives, have you paid close attention to post-development testing? Did it help? If not, is there something you or your team would've done differently prior to deployment? Let me know below.
Recommended Reading For You:
3 Mistakes Leaders Can Avoid When Buying AI Solutions
How to Develop Production Ready NLP Solutions
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Kavita Ganesan
Kavita Ganesan is an AI strategist, consultant, and the founder of Opinosis Analytics. She has over a decade of experience in helping Fortune 500 companies and smaller organizations around the world get results from AI initiatives and bring their AI vision to life. Learn more about Kavita here.
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The electric utility industry is changing rapidly. The U.S. Energy Information Administration (EIA) said its most recent data shows about 17,000 MW of coal generation capacity was retired between January 2017 and June 2018-about 6,300 MW in 2017, and about 10,650 MW in the first six months of 2018.
While there is increased conservation throughout most sectors, the use of electricity in the United States is at an all-time high. The loss of the coal fired generating stations and the retirement of some of our nuclear plants is putting the burden of electrical production on the rapidly expanding renewable markets (primarily wind and solar), and gas fired simple and combined cycle plants. This is not surprising.
Modern combined cycle plants are hovering around 60% efficiency as opposed to 35% average efficiency for coal plants. Combined cycle plants requires 80% fewer workers per MW to sustain their operation, substantially reducing their operating cost. Gas prices are very low, and using natural gas for electrical generation produces approximately 65% to 85% less carbon dioxide per MW of generation than coal. It is easy to see why coal fired plants are being rapidly replaced by other, cheaper, cleaner sources in the United States.
The increased dependency on gas fired combined cycle plants is rapidly changing how they are operated. Ten years ago the average combined cycle plant was started and stopped several times a week to cover peak generation periods. The baseload generation was relegated to the coal and nuclear plants. As the coal and nuclear plants are being phased-out, combined cycle plants are increasingly being put into baseload operation.
Operators that once routinely started and shutdown their plants are now sitting on continuously running (baseload) units. I was recently in a combined cycle plant that had operators, due to shift schedules, holidays, etc. that had not seen or experienced a start-up or shutdown in over 5 years. How does an operator maintain proficiency of plant operation under these conditions?
The only answer to this is simulation. The combined cycle industry has been slow to adopt simulation for their training needs because of minimal manpower and the relatively high cost of a simulator making it cost prohibitive to them. However, as the industry moves to more baseload combined cycle plants, simulation becomes cost effective.
SimGenics has cost effective solutions that include high fidelity, real-time simulators that identically match the plant and we also have a number of generic, non plant-specific simulators that can be effectively used to teach cause and effect and fundamentals.
We have substantially reduced the cost of high fidelity simulators with our SimuPact simulation development tools. SimuPact is the latest, arguably the best simulation development tool on the market today. If there is interest in finding out more about SimuPact, or any of our product lines please contact us.


9 out of 10 based on 991 ratings. 4,287 user reviews.
Web viewLab Activity: Periodicity of Properties of the Elements on Microsoft Excel. Background. The periodic table is an arrangement of elements based on atomic number. The modern Periodic Table was developed in 1913 by Henry Moseley. He used X-rays to identify the atomic number of each element.


text:
Q: Видеоплеер на основании урока в NetBeans Создал видеоплеер на основании видеоурока. Код:
import java.awt.BorderLayout;
import java.awt.Component;
import java.awt.Container;
import java.awt.Dimension;
import java.awt.Toolkit;
import java.awt.event.ActionEvent;
import java.awt.event.ActionListener;
import java.io.File;
import java.io.FileNotFoundException;
import javax.media.ControllerListener;
import javax.media.Manager;
import javax.media.*;

public class VideoPlayer extends javax.swing.JFrame implements  ActionListener, ControllerListener {
    File file;
    Player player;
    Component controlcom;
    Container con;

public VideoPlayer() {
    initComponents();
}

private void initComponents() {

    filechooser = new javax.swing.JFileChooser();
    jMenuBar1 = new javax.swing.JMenuBar();
    jMenu1 = new javax.swing.JMenu();
    jMenuItem1 = new javax.swing.JMenuItem();
    jMenuItem2 = new javax.swing.JMenuItem();

    setDefaultCloseOperation(javax.swing.WindowConstants.EXIT_ON_CLOSE);
    setPreferredSize(new java.awt.Dimension(800, 600));
    addWindowListener(new java.awt.event.WindowAdapter() {
        public void windowOpened(java.awt.event.WindowEvent evt) {
            formWindowOpened(evt);
        }
    });

    jMenu1.setText("Файл");

    jMenuItem1.setText("Відкрити");
    jMenuItem1.addActionListener(new java.awt.event.ActionListener() {
        public void actionPerformed(java.awt.event.ActionEvent evt) {
            jMenuItem1ActionPerformed(evt);
        }
    });
    jMenu1.add(jMenuItem1);

    jMenuItem2.setText("Вихід");
    jMenuItem2.addActionListener(new java.awt.event.ActionListener() {
        public void actionPerformed(java.awt.event.ActionEvent evt) {
            jMenuItem2ActionPerformed(evt);
        }
    });
    jMenu1.add(jMenuItem2);

    jMenuBar1.add(jMenu1);

    setJMenuBar(jMenuBar1);

    javax.swing.GroupLayout layout = new javax.swing.GroupLayout(getContentPane());
    getContentPane().setLayout(layout);
    layout.setHorizontalGroup(
        layout.createParallelGroup(javax.swing.GroupLayout.Alignment.LEADING)
        .addGap(0, 745, Short.MAX_VALUE)
    );
    layout.setVerticalGroup(
        layout.createParallelGroup(javax.swing.GroupLayout.Alignment.LEADING)
        .addGap(0, 350, Short.MAX_VALUE)
    );

    pack();
}

private void jMenuItem2ActionPerformed(java.awt.event.ActionEvent evt) {
    new Start().setVisible(true);

}

private void jMenuItem1ActionPerformed(java.awt.event.ActionEvent evt) {
    try{getFile();
    createFile();}
    catch(Exception e){}

}

private void formWindowOpened(java.awt.event.WindowEvent evt) {
     Dimension sSize = Toolkit.getDefaultToolkit ().getScreenSize ();
    setSize (sSize);
    setResizable(false);
}
public static void main(String args[]) {

    java.awt.EventQueue.invokeLater(new Runnable() {
        public void run() {
            new VideoPlayer().setVisible(true);
        }
    });
}

private javax.swing.JFileChooser filechooser;
private javax.swing.JMenu jMenu1;
private javax.swing.JMenuBar jMenuBar1;
private javax.swing.JMenuItem jMenuItem1;
private javax.swing.JMenuItem jMenuItem2;

public void controllerUpdate(ControllerEvent ce) {
    try {
        con = getContentPane();
        if (ce instanceof RealizeCompleteEvent) {
        Component visualcomponent = player.getVisualComponent();

        if(visualcomponent!= null) {
            con.add(visualcomponent,BorderLayout.CENTER);}
            controlcom = player.getControlPanelComponent();}
            if(controlcom!=null){
                con.add(controlcom,BorderLayout.SOUTH);
            }
                con.doLayout();
            } catch(Exception e){}
        }

private void getFile() throws FileNotFoundException {
   filechooser.showOpenDialog(this);

    file = filechooser.getSelectedFile();
    if(file.exists()){
    throw new FileNotFoundException();}
}

private void createFile() {
 try{player = Manager.createRealizedPlayer(file.toURL());
 player.addControllerListener(this);
 player.realize();}
 catch(Exception e){}
}

@Override
public void actionPerformed(ActionEvent e) {
    throw new UnsupportedOperationException("Not supported yet."); //To change body of generated methods, choose Tools | Templates.
}
}

В конечном итоге файл не открывается ни MPEG, как на видео, ни как-либо ещё.
Ошибка

Unable to handle format: MPEG, 1280x720, FrameRate=29.9, Length=1382400

redpajama_set_name: RedPajamaStackExchange


text:
Another project from 2nd year Algorithms & Data Structures. Here is the readme that was included with it:

everything's very straightforward and set up through the Makefile..

just run "make", then try giving the different programs different inputs or outputs

there's a testing suite I wrote on the sub-folder called "testing".

Most of the testing is done with 2 programs:
	-> testing/script.sh:

	A shell script which generates a type of
	input, feeds it to the algorithm, and
	feeds the clusters into the R-program to
	export it to PDF.
	Try editing it before executing it.

	-> ./test_all:

	A C program which performs a group of
	specific tests on the programs.

redpajama_set_name: RedPajamaGithub


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text:
Q: OverflowError exception not detected in python This is my following program
try:
    class __Euler3__:
    n = 600851475143
    primeFactors = []

    for i in range(2,n):
        if (n%i ==0):
            primeFactors.append(i)
            n = n/i
            i = i -1 #reset i
            print primeFactors

except OverflowError as e:
       print "the error is" , e

but for some reason the Overflowerror mechanism is not able to catch this exception
I am using python 2.7

A: OverflowError is raised when you can't represent the number because it's too big.  That doesn't happen with python integers (as they seamlessly turn into long when they get too big, and in python3 all integers are long i.e. arbitrary precision.).
Quoting straight from the documentation (with some emphasis added):

Raised when the result of an arithmetic operation is too large to be represented. This cannot occur for long integers (which would rather raise MemoryError than give up) and for most operations with plain integers, which return a long integer instead. Because of the lack of standardization of floating point exception handling in C, most floating point operations also aren't checked.

A: As mgilson pointed out, no OverflowError is raised. In future, if you want to check whether the code exits silently or works, you can use try/except/else:
try:
    foo()
    baz()
except:
    print "error"
else:
    print "no error!"

A: According to this thread http://www.velocityreviews.com/forums/t701480-for-loop-range-result-has-too-many-items.html ,  range() can raise an overflow error depending on your system.  Running this code on my 32 bit system with python 2.7. I get "OverflowError('range() result has too many items',)"


We are all proud to be Americans and want to celebrate the July 4th holiday. But as you celebrate, be aware that the police will be watching you as leave the firework show. If your Independence Day plans include alcohol, make sure you don't get behind the wheel of a car, truck, boat, motorcycle, or any other kind of motor vehicle. Law enforcement will be on the lookout for drunk drivers to keep our roadways safe.
A DWI is a serious crime in Collin County that could result in jail time, fines, and a suspension of driving privileges, which could have a huge impact on your family obligations and employment situation. With so much at stake, it is important to involve an attorney as soon as possible after an arrest.
Remember, even buzzed driving is drunk driving, and is not worth the risk to yourself and to others. We hope you don't have to call us, but if your Fourth of July involves a DWI arrest, know that we are here to help. Widely respected and trusted throughout Collin County for DWI defense, you can count on us to defend your driving privileges and help you get back on track.
At Rosenthal & Wadas, we are dedicated to helping people resolve their sensitive legal issues, get through challenging times and move forward into a brighter future. To discuss your case and best defense options for proceeding, call us to set up a free consultation at 972-369-0577.
‹ What Is an Administrative License Revocation (ALR) Hearing?


text:
Grimm State of Mind
The October half-term is as always wet and grey, but for a group of teenagers thrown together on a drama project, it's a time to discover who they are, and find a way to take their next steps in a world filled with uncertainty. Each have their own 'backstories' and motivation and like the characters they play, must find a way of letting go and moving on. It's Wednesday already and the performance will take place on Friday evening. Dylan's mum is in hospital and he's only doing this because she wants him to. Doris has been given a week respite by her newly appointed social worker, and Damon has only joined in the project to work off the cost of replacing the plate glass he smashed at the theatre. Patricia and Delius are as usual palmed off anywhere that is handy for their parents. Somehow they must pull together to form the 'Hansel and Gretel' company and create the best performance yet for their director Anthony. There is a deeper and more mysterious narrative played out on stage. Obsessions and tragedy, both unseen and unspoken, and the 'Magic of Theatre' grips the very heart of the production. The startling similarities of protagonists and Director are interwoven in this narrative delight. What is happening to the Towns of Stoke-On-Trent? How are Anthony's obsessions affecting the real world. Who are the unseen? And will the characters on stage resolve their own inner conflicts. The curtain calls....What wonder lurks behind?
Buy 'Grimm State of Mind' at Amazon


A sincere thanks to Dr. Jean for taking the time to talk about hyperthyroidism in cats with us.
You can listen to the recorded version here: Feline Hyperthyroidism Interview with Dr. Jean Hofve or just click play below.
Jenny: Hello Floppycats subscribers. Today, we're talking with Dr. Jean Hofve about feline hyperthyroidism. And Dr. Jean is a holistic vet and she runs Little Big Cat which is her website, it's LittleBigCat.com. And she also has several books that she sells on the site and also on Amazon so I'll link to those in the written description of this recording. Dr. Jean, thank you so much for letting us bug you again.
Dr. Jean: Oh, my pleasure.
Jenny: So today, feline hypothyroidism, can you kind of tell us what it is?
Dr. Jean: Well, the thyroid gland – in cats it's actually a pair of glands – they sit on either side of the windpipe at the base of the throat. And the thyroid is kind of the master gland of the body in a lot of ways, and what it does, mainly, is it controls the basal metabolic rate. Well, what does that mean? That is just the speed at which your cat's body functions. It's kind of like a thermostat. So if you turn the thermostat down, which would be hypothyroidism which is common in dogs, they basically get sluggish and they gain weight and that sort of thing. Cats get the opposite, hyperthyroidism, so you're cranking the thermostat up and it makes them digest food faster. So sometimes you have vomiting and diarrhea because things are just going completely bonkers through there. They become a little more active, not all cats but it increases the heart rate, it increases hyper behavior. A lot of times they'll start howling at night. And they eat like a son of a gun but they will lose weight because they're burning calories at a faster rate because that thermostat's been turned up.
Jenny: Okay. So at what age do cats typically acquire hyperthyroidism?
Dr. Jean: Usually they're older. I think the youngest I've heard is seven years, but it's usually 9, 10, 11 years of age. It's an older kitty disease.
Dr. Jean: Yeah, that's a really great one because I hear this from my friends all the time that my cat has started going bonkers at night. So the increased appetite, most of them eat more. They will lose weight anyways, and sometimes they lose weight pretty dramatically pretty quickly. So you get this anxiety or hyper kind of behavior, including the howling at night. Because they're going through calories and body water so fast, they're thirsty. So they drink a lot, they pee a lot, so everything is turned up, and vomiting and diarrhea. Now, the most difficult thing about the disease is that not all cats will have the symptoms. Some cats get sluggish. Some cats get lethargic or they eat less. But usually in 80% of cases you'll have some of the signs of that turned up thermostat kind of behavior.
Jenny: Okay. Because I'm thinking urine output with an older cat, I'm always thinking kidney but it definitely could be a hyperthyroid thing too.
Dr. Jean: It could and often they go together. Older cats, they get old and their functions start to decline. One thing that's real tricky about thyroid disease is because it does increase blood pressure and heart rate, that actually increases the blood flow to the kidneys. So if you have kidneys that are kind of marginal or starting to go, the function is starting to really decline, being hyperthyroid can actually mask that so the cat will act normal longer than it would have otherwise. So when we talk about treatment, there are some real serious implications about treating that. But there are a lot of things that can cause the drink a lot, pee a lot syndrome – kidneys was the most common, but diabetes, thyroid disease, liver disease, a whole bunch of things can cause that. So if you have a cat who suddenly increases drinking and urine output, you really want to have your vet do some blood work. And in a cat over seven or eight years of age, all the veterinary labs have a test panel that include thyroid. Always get the thyroid checked if you're doing blood work on an older cat. That's just simple and you may be able to catch things in the early stages where damage has not really been done.
Jenny: Okay. So the only test that you can do is a blood test to figure out?
Dr. Jean: That's the first screening test. There are some other tests that can confirm. There are radioactive CAT scans or bone scans, or you can shoot radioactivity in. That's got iodine and iodine collects in the thyroid so you can actually see on the scan results, you can see the thyroid. That maybe an indicator for some cats because one thing about the thyroid is you can have thyroid tissue kind of scattered all over the place. In the embryo, when the thyroid gland kind of starts to form, it has to migrate up to where it's going to be at the base of the throat. Well, sometimes thyroid cells get shed along the way and you can have no signs of an enlarged thyroid or anything, but there will be a thyroid nodule in the chest where you can't see it or feel it or anything. That can be a real problem for these guys when you're trying to treat them.
Jenny: Wow, yeah. I didn't know about that. Wow. That makes it very complicated.
Dr. Jean: Yeah. I had one kitty who had actually had her thyroid glands removed and the surgeon originally put this cat on thyroid supplementation because there's often thyroid tissue somewhere else. That is almost never necessary. But this person felt that she wanted to keep the cat on that medication. Well, the cat became hyperthyroid again and it turned out that she had a massive thyroid tumor in her chest. So it was really shocking. I mean, the thing was a couple inches across. This is a strange disease and it's something that you really want to stay on top of if you've got it going on.
Jenny: Wow. That is fascinating. I didn't share this with you but I was hyperthyroid for eight years. So, I know a lot about hyperthyroidism in humans. But, wow, that's fascinating.
Dr. Jean: It's like living on a caffeine drip, isn't it?
Jenny: Yeah. Yes, and it is a beast to manage. Okay, so what are some of the causes of hyperthyroidism in kitties?
Dr. Jean: Well, did you know that steel cans are lined with plastic? It turns out stainless steel isn't stainless, and it will rust. And what causes it to rest? Water. Oh brilliant. Okay, so if you buy a stainless steel, BPA free water bottle, or aluminum one and you think there's no plastic in this, they're all lined with plastic, every one of them. And so cat food cans are lined with plastic and BPA is found in the plastic in a lot of foods. A few foods have taken it out. A few foods have substituted a different kind of plastic that's probably even worse. But the thing about BPA, it is an endocrine disruptor. Endocrine means the hormones like thyroid hormone or insulin or those kinds of hormones that run around in the body and do many important things. That can be disrupted by these chemicals. So that's a thought. Another idea that has been tested and shown to have some merit is fire retardant chemicals. They're called PBDEs (Polybrominated diphenyl ethers) and I'm not going to even try to tell you what that is. It's interesting that thyroid disease was first documented, first found at UC Davis near Sacramento, California. And it was a few years after California started mandating the addition of fire retardant chemicals through things like carpet, furniture, clothing, baby toys and things like that. And so when these fire retardants all of a sudden became extremely common and everything was saturated in them, all of a sudden now our cats are getting this weird disease. So, there is some thought that that's part of what's going on. And the thing about the PBDEs is they're kind of ubiquitous in the carpet and the furniture. So they're present in dust. Well, cats like to sleep on warm things like stereos and TVs where dust collects, static collects, and then they groom it off and they are ingesting these chemicals, and they're walking across your fire retardant carpet and licking it off their feet and it's being taken up by the dust mites and they're grooming those off. So that's a very good thought, and the other thing about PBDEs is they are also found in food. A lot of cat foods have been tested and the two ingredients that are fish and chicken byproducts, well, those are also the flavors of foods that are the most implicated with possibly the lining, possibly with the ingredients. I think what we can say for sure is that there are many factors and probably no one thing that does it. But if you have a cat that's susceptible and their thyroid function may be a little bit off, their regulation is a little bit off and they're more susceptible to develop these diseases, you start getting one or two or three of these triggers and they're going to develop the disease. It's become so rampant. It's not yet half of older cats, but I think it's close to a third of older cats you can kind of bet that they're going to develop this disease.
Jenny: I'm just going to knock on wood that it doesn't happen to my two little guys.
Dr. Jean: Yeah. I had a cat that did develop it. It was 20 something years ago. She was born and raised in California. Is that the problem? She didn't eat that much fish, I didn't feed her fish. She got homemade food, but at some point in her life, she did get a lot of Fancy Feast. So is that what it was or was it the can liners, now they've all changed? It used to be when the first study came out about the BPA in the plastic, the most common can liners were the white ones. Well, that's not true anymore and it can be in any of them. Some of the white ones are fine now, and some of the silver ones are worse. It's very difficult. It's very difficult to figure out.
Jenny: Another reason why I need to switch my guys to raw.
Dr. Jean: Exactly, or homemade. Every day I find out something new about the food supply and the Roundup in the food. Every day I find new evidence as to why you really have to make your own cat food. And I know that's not practical for a lot of people so we've got to deal the hand we've been dealt. We've got to play those cards, so we do the best we can.
Jenny: Right. Well, so once you've got a hyperthyroid kitty, what are your treatment options?
Dr. Jean: Well, it used to be, back when I started practicing, there were only two. There's a drug called Methimazole and that binds up the iodine and prevents the thyroid from making active thyroid hormone or surgery to remove the thyroid. The surgery is a little tricky and there can be some pretty serious complications. It's not that difficult of a surgery but there are other glands involved and you're operating in an area that has a lot of really important things like your carotid arteries and your veins and your nerves and things. But then a number of years ago, it's probably been close to 20 years now, I'm dating myself, but now you can have your cat irradiated with radioactive iodine. Iodine collects in the thyroid and the radioactivity destroys thyroid tissue. The advantage of that is it destroys the thyroid tissue wherever in the body it is. So even if you do have one of those oddball interstolastic tumors, the iodine will get that too. The downside, it's kind of expensive. It can be anywhere from $1000 to $2000. A cat has to be hospitalized because for a number of days, through a week or so, its pee and poo are radioactive and they are a walking, brewing biohazard. And the government does not let you have one of those in your house so they have to be hospitalized. That is a definitive treatment. It works really, really well. It's almost the ideal treatment except for the whole radioactive thing. And some cats don't really do well away from home that long. These are little old cats, they're old cats and they're fragile. And there is a distinct problem as we talked about a little earlier about the kidney and thyroid disease if you have both, if your cat has both. You may not know about kidney disease. But if you suddenly shut off the thyroid hormone, that kidney disease is going to become overt very, very fast. And it is recommended use the drug to bring the thyroid levels down to normal first so you know that your cat's kidneys are okay on that lower amount of thyroid circulating in the body and that it's not going to go into catastrophic kidney failure the next day which happened in a number of cases early on.
Dr. Jean: You remove the thyroid hormone completely and all of a sudden the cat is thrown into severe kidney failure just overnight because you're massively reducing the blood flow to the kidneys and kidneys, they don't like that. There's a newer treatment. It's made by Hill's Prescription Diet and it's called YD. It's an iodine deficient diet. Now Hill's likes to say oh just feed YD and only feed YD because animal products tend to have a lot of iodine in them so this, their dry food, is pretty much a vegetarian food which is not great for cats. But if that food is fed exclusively, Hill's claims that the thyroid levels will come down to normal within a few weeks. Now here's the problem. Most of us have more than one cat, right. If you have one hyperthyroid cat, you cannot feed this diet to the other cats in the house. It will hurt them because it is so deficient in iodine, way below the known minimum healthy concentration of iodine. So it's tricky to feed if you've got multiple cats. For animals that you don't want to do any of the other treatments, it's an option. But there are problems with it. It's a terrible food in terms of nutrition. It's got soy and corn in it which are both genetically modified. So now you have a roundup factory in your cat's gut.
Jenny: Well, and as someone who has hyperthyroid, my thirst was out of control. Having a kidney cat or any older cat and dry food, ugh, that doesn't make any sense to me.
Dr. Jean: Yeah. Dry food is terrible for cats anyway and it's especially terrible for older cats. And older cats really need more and better protein. They do better on a higher quality protein because old cats tend to lose weight no matter what is going whether they have kidney or any other disease. They just tend to get skinny when they get older. So you really want to make sure you're feeding a very high quality food. Well this ain't it. But I was just reading a case on the veterinarian boards. A100 year old lady couldn't kill her cat and didn't have $1000 or $1500 laying around to do the iodine. So it was very limited what she could do. So the diet might be a good choice for someone in that situation. I just don't have a good feeling about it and none of the experts are recommending it. It's something to try if you're kind of stuck. With the drug, it is a pill but it can be made into a gel that you apply to the inside of the cat's ear every day and that works pretty well. The problem with the drug is that cats tend to develop an allergy to it and when they do that then you can't use it anymore and now you're left with very little or no way of options. It's complicated. Life is getting so complicated. Have you noticed that, Jenny?
Jenny: Yes. And the gel thing too, I remember a few years back, Methimazole is what I took. So a few years back, one of my readers contacted me and said had her cat has hyperthyroidism and I asked her what they were doing and she said, oh, I apply the gel. And I said, gel? I was like do you wear gloves or something? Is that not transported to you, you're going to hurt your thyroid?
Dr. Jean: Yeah, it sure is. So either you have to wash your hands immediately or usually the vet will give you a bunch of rubber gloves and you just cut off the tips and stick it on your finger and use that to rub it in. But yes, you will become hyperthyroid if you apply that every day to your cat and you don't protect yourself.
Jenny: And the other cats. Yes.
Dr. Jean: That's a good point, and it's also through any other topical hormone like topical testosterone, topical estrogen, topical progesterone that people use for themselves and then pet the cat or the dog. You put it on, and then you put lotion on, and then the dog licks it off. And now all of a sudden your spade dog comes in to eat. Hormones are not something to treat lightly. Just a little teeny tiny bit can really mess you up.
Dr. Jean: You put it on your upper arm, then your cat sleeps next to you and it's like oh my goodness. Life is complicated.
Jenny: So more on the radioactive iodine, a few years back, the Cat Writer's Association sent out an email about a company, I think it was in Chicago. I interviewed them on the site but I haven't looked at it for a few years. They were selling a cleanup kit for radioactive iodine because I guess there were some vets that were letting the cat go home the same day or the next day. So that should be a warning sign, right, if the vet's willing to let you take the cat home the next day?
Dr. Jean: I think so. Now, I haven't looked at the protocol lately but it used to be the cat had to stay in the hospital for two or three weeks. They've done it down to five or seven days, but I think they still need to stay in the hospital. It is radioactive waste and it has to be treated. You can't just send that out into the community.
Jenny: Right. That was one of my problems as a human with that risk factor. So to avoid radioactive iodine exposure in the home, as far as you know it's like a seven day period?
Dr. Jean: Yeah, I believe that's what it is. I could look into it or you could. Radiocat is the name of the company that has kind of made a career out of doing that. They have centers all over the place. In any big city, you probably have a facility there.
Jenny: Okay. In a human, the radioactive iodine usually kills enough and then you end up having to take a thyroid supplement for the rest of your life. But cats don't need that?
Dr. Jean: Usually, they do not need thyroid supplementation. Weird. I don't know why. But usually they don't. It should never be prescribed just without thinking about it for long-term because the body will make up for that somehow. Cats are really interesting animals and they have ways of dealing with things that are just beyond comprehension sometimes. But it's very, very rare for a cat to me that would supplementation even if you destroy the glands. I don't know why.
Jenny: Yes, that is very curious but nice at the same time.
Dr. Jean: Yeah because you're trading one pill for another pill and while Methimazole is really well absorbed through the gel through the ear, the same is not true of the thyroid hormones. Now you have a pill that you have to give. Let me just say this because it's just triggered a thought not exactly on topic but a compounding pharmacy will put anything into a gel that you ask it to do. However, they do not guarantee whether the drug will be absorbed by that gel. For example, Amitriptyline which is an anti-depressant and it's used for anxiety and aggression, and compounding pharmacies will put Amitriptyline in a gel for you. It is not absorbed at all through that route. So you are paying for something that is not going to work. But they will not tell you it's not going to work. So you've got to make sure your vet has researched it and understands that they're going to put a steroid or some other kind of thing into a gel, make sure that they have done the studies that show that it's actually absorbed that way. Hormones tend to be absorbed pretty well through that route because it's a natural substance. But it's not always the case. So if your cat or your dog has to be on some kind of medication and you think, oh, hey we could put it in a gel. Well, you can, but whether it's going to work or not is a whole different topic.
Jenny: Yeah. Interesting. Okay. Well, I guess we sort of covered this a little bit but I figured I'd just ask it again, are there any ways to lessen the chance of a cat developing it?
Dr. Jean: Well, possibly. I mean, dust a lot, make sure if you've got carpets and furniture with fire retardants in them, think about getting a hardwood floor or really keep your dust low so that your cat's not ingesting that kind of stuff. I would stay away from foods that contain fish and byproducts just because those particular ingredients have been associated with more thyroid disease than other ingredients, and they do contain higher levels of BPAs than other, rather the PBDEs, the fire retardants. This stuff is ubiquitous in the environment but the ocean is really a wonderful sponge for soaking up pollution and there's a lot of it floating around there for the fish to eat. And if you're not going to home make food, I do recommend canned food. But maybe you can find a manufacturer, they change all the time so you're going to want to call, ask them if they've taken BPA out of their cans and if they have make sure they haven't put BPB or BPF or BP any other kind of thing in there instead. It's real tricky. I would say feed a homemade diet as much as possible. Go organic if you can. It's kind of a disease as just hanging around on planet earth for long enough some of these kitties. And there's not a whole lot of prevention that you can do. But if you can do the diet and keep things – if you know that the BPA is a problem and you know that the fire retardants are a problem, try and get rid of them as much as you can in your house.
Jenny: Okay. Well that is all that I had for today unless you had something else that I should have brought up that I didn't.
Dr. Jean: No, I don't have any brilliant ideas but it's a tough disease. It's not fatal. Oh, yes, we do have something else we have to talk about. We have to talk about the heart.
Jenny: Yes. I'm laughing because I'm three years into remission so it's not as obvious in my head anymore. Yes.
Dr. Jean: Yes, well because thyroid hormone increases the heart rate. In kitties, that's not a good thing. The heart is a muscle and if you exercise a muscle you get big musclebound muscles and in cats you can get heart failure with that. It's a particular type of heart disease called hypertrophic cardiomyopathy. The heart is in a sack and for some reason in these kitties the sack doesn't expand as well or for some reason the muscle grows inward. So you've got a fairly normal sized heart but the walls have gotten thicker. Well that means that the chambers have gotten smaller and eventually the blood can actually clot right in the heart and when the heart pumps, it'll fly out and cause a serious thrombus. Usually that happens where the aorta splits to go down the hind legs. It's incredibly painful. It's called a saddle thrombus. And if your cat throws one, he's going to scream bloody murder and they're going to drop in the hind end like they've been shot. They're completely paralyzed in the hind end. It is possible for them to recover but usually if the heart is that bad and you have that kind of thing, that's usually fatal. You could get embolizer go elsewhere but we don't see that as much. You have to treat this because they look fine, they're eating good, they really feel pretty good because there on caffeine all the time and they feel pretty awesome. So you might think, well, I guess I won't do much of anything about it. Well, if you don't do anything about it, the cat's going to die a really, really horrible death. So you don't want to do that either.
Jenny: Right. Do they get a goiter?
Dr. Jean: In cats, it is a benign thyroid tumor. And because it's benign, that means the cells are pretty normal which means they're pumping out a lot of thyroid hormone. So yeah. There has not been a link to vaccinations elucidated except for in dogs. Most hypothyroid in dogs probably is related to vaccine induced antibodies attacking the thyroid. So we don't know, and cats don't over vaccinate. That's going to save your kidneys, that's going to save a whole lot of other… So just in general, the best diet you can and the minimal vaccines, once your cat is an adult, rabies is required by law almost everywhere. But nothing else is really necessary. So they don't need annual boosters or even every three years or even every five years. The kitten vaccinations are so effective, they're essentially set for life. So don't keep doing that.
Jenny: Okay. It's always something I have a little fight with my vet with and I say I'm not budging so are we done?
Dr. Jean: Yeah. You've got to do rabies. That's required by law. If you choose not to – I had a client who is also a really good friend and she had a cat named Spike and he was the cat from you know where, a very hot place. And I even went and did a house call and tried and still couldn't get near him. So he didn't get his rabies vaccine. A couple of weeks later he shredded the brother in law or the neighbor's brother in law or something and she got cited for not having him vaccinated. And I wrote a letter to the judge on her behalf. I said your honor, I would be happy to give you this shot and you go do it because this cat cannot be vaccinated. Okay, case dismissed. And most likely, cats that have had the first few rabies vaccines, they're probably also protected. But because it's a public health hazard and it will kill you, the law does take very dim view of not keeping up with those vaccines.
Jenny: Alright. Well thank you very, very much for the hyperthyroidism talk. I've totally forgotten about the heart rate thing and that heart failure thing would be a horrible way to lose your cat.
Dr. Jean: We talked about the increased heart rate but then I forgot to explain why that's a problem.
Jenny: Yes. Yes. It's so crucial.
Dr. Jean: We got it.
Jenny: Yeah. Thank you very, very much and please continue to let me know about your new projects and that sort of thing so that I can share them on Floppycats.
Dr. Jean: Okay, will do.
Jenny: I know everybody loves hearing from you.
Dr. Jean: Well, thanks. It's so much fun to work with you. I really enjoy it.
Thank you so much, Dr. Jean & Jenny! I had no idea about any of THIS information about Feline Hypothyroidism! But, now I do! As always, your interviews with Dr. Jean are insightful and helpful and full of great information to learn more about our beloved feline's overall health and risks to their health.
=) "sugarbunny" because of easter around the corner?
great article jenny! it seems to be just like with us.. nothing is safe anymore. it's beyond frustrating. i had a cat with hyperthyroidism and i had to give him medicine every day. i actually went the wholistic way, i didn't buy prescription stuff. it helped a lot. i think now about all the containers that cat food comes in now and that pisses me off that they do that. they need to start putting them in glass then, like they do baby food. grrr it makes me mad. at least now i'm better informed so thanks again to you and dr jean.
=)….i think awareness is key…i don't have the energy or mental interest in worrying about every little thing, but the more i am aware, the more i can hopefully prevent or limit exposure to.


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Home > Vape Gear Reviews > Atomizers > Vision Vivi NOVA v2.5 Tank System – A Perfect Holiday Gift!
Yesterday I received a new tank from our buddies at MyVaporStore and I've been using it non-stop, loving every minute of it. In fact, I am enjoying it so much that I decided to forego the usual 1-week review time so that I can bring this new tank to your attention with enough time left to pick up some of these great tanks for yourself and for every Vaper on your Holiday Gift Giving List.
The Vision NOVA holds at least 3.5ml of eLiquid. For most people this is enough for all-day vaping and if used with a long-lasting battery such as the new ZMAX, a Lambo, Provari, VTube, or even the Bolt and the new Telescope, you won't have to concern yourself with running out of power or eJuice from the moment you wake up to the moment you go to sleep.
The Tank is comprised of a 510-drip tip and four threaded pieces that makes it extremely easy to assemble, clean, and fill. When fastened together it provides a secure lock. The STV Nova is easy to fill and features a replaceable atomizer head. When the atomizer head burns out, simply unscrew one of the end caps and the atomizer head and replace with a new atomizer head.
The heads produce excellent flavor, vapor and throat hit. To fill it, simply remove the end cap and fill to your desired level. No special syringe is needed. As always, avoid getting liquid into the center tube. The STV Nova system can be disassembled easily for cleaning. Each STV Nova Tank System includes three atomizer heads with long wicks. The wicks can be trimmed down to your desired length.
510 Threaded: Compatible with Joye Ego Series batteries, MVari, the BOLT and ZMAX.
Although I've only used it for about 10 hours (of actual use) I can attest to this beautiful tank being extremely well built, leak proof, easy to fill and easy to disassemble and put back together. There isn't a word of exaggeration in the above information from MyVaporStore.
The colors are as gorgeous as the colors Apple uses with their colorful iPods. The finish on the metal outer sleeve feels like a rubberized paint job but I can't really tell. It feels…right. The size is perfect for a full size ZMAX and even the shorter ProVari mini and anything in-between.
They are packaged in the same type of packaging as other ViVi NOVA's so it would make a great little boxed gift all wrapped up in holiday wrapping paper.
With a price of $13.99, which includes a couple of extra atty heads (one is already attached to the tank, two more are set in the box) it's a perfect 'price point' as a stocking stuffer or straight up gift under the tree.
The Vision NOVA STV v2.5 comes in Black, Red, Blue (my fav) and Silver. If you're looking for an affordable gift that is certain to delight, head over to MyVaporStore and get your order in while it's still available. I have a feeling these things are going to sell like crazy so pick up one for yourself too.


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Non-biological Complex Drugs (NBCDs) are medical compounds that cannot be defined as small molecular, fully identifiable drugs with active pharmaceutical ingredients. They are highly complex and cannot be defined as biologicals as they are not derived from living materials. NBCDs are synthetic complex compounds and they contain non-homomolecular, closely related molecular structures with often nanoparticular properties. This is, for instance, the case with the iron sucrose and its similars. But also with other drug products, e.g. polypeptides (glatiramoids), swelling polymers, liposomes as the NBCD class is growing. Hence and due to their complexity and specific composition mix, such colloidal iron carbohydrate drugs cannot be fully identified, characterized, quantitated and/or described by physiochemical means to define their pharmaceutical properties. Therefore, contradictory to the generic paradigm pathway, relying on a full pharmaceutical identity and sameness in vitro evaluation exercise, they need additional (biological, in vivo) evaluation with a reference product to assess comparability e.g. in tissue targeting in the body. This requires an appropriate, yet to be defined and be harmonized regulatory approach for these new class of medicinal products. The profile and the performance of NBCDs is defined by the multi-step manufacturing process, which is laborious, difficult to control and not disclosed by intellectual property. Minimal changes in for instance the starting materials or the process conditions might result in significant clinical differences affecting therapeutic effects or safety.

Clinical Data
Studies have shown differences in therapeutic and safety effects between originator NBCDs and approved similar, even though these compounds had shown high similarities in physicochemical character. The structures responsible for these therapeutic differences are unknown. The differences in efficiency and safety (in vivo profile) cannot be detected in in vitro testing, as it is impossible to isolate and fully characterize these compounds. Nor are there defined models for proper evaluation. Furthermore, it is unknown what to look for and what causes the differences, due to a lack of understanding of the exact composition. This calls for additional characterization in biological systems including clinical head-to-head analysis to define the extent of similarity and the place in therapy as therapeutic alternatives or interchangeable/substitutable medicinal products. Clear evidence for these observations comes from retrospective studies on iron sucrose and iron sucrose similars.

Approval challenges for iron sucrose similars
NBCDs have been approved according to the classical generic paradigm based on pharmaceutical equivalence and bioequivalence without realizing the nano-properties of these type of medicinal compounds. Therefore, these compounds were seen as therapeutically equivalent. As mentioned above such an approach is not valid for follow-on versions of NBCDs. The classical generic approach disregards the complexity of NBCD compounds (pharmaceutical and biodistribution aspects) as they cannot be fully characterized in vitro, which is a prerequisite for the generic approach to predict pharmaceutical (quality) equivalence. The reason is the complexity and the non-homologous composition of these synthetic large molecular products. Even slight differences in manufacturing might result in therapeutic or safety differences not to be attributed to a known or defined component.

The existing and defined biosimilar pathway, taking into consideration the complexity of biologics and its follow-on products, is neither applicable for NBCDs and its similars. Since NBCDs are by definition not biologicals but are rather synthetic. However, basic principles can be used for an NBCD similar evaluation. Since the NBCD follow-on versions are not identical but only similar to the originator product, they are never the same as it is with generic small molecule products. NBCDs and their similars containing nanoparticulate can also be referred to as nanosimilars (see figure 1). A stepwise quality, non-clinical and clinical approach is suggested for market approval of NBCD nanosimilars and to show comparability. There is a lack of non-clinical models to test such products like e.g. the rodent approach addressed by EMA in their reference paper for the NBCDs iron sucrose and its similars. Recently, the hatching egg model was used as an alternative model to study time-dependent iron concentrations in heart and liver avian tissues for various intravenous iron complexes applied in equimolar doses. Such models need in-depth evaluation and validation to demonstrate robustness and to further define potential use in an evaluation and comparison testing. When evaluated similar enough, the challenge then still is to define to either use them as a therapeutic alternative or as an equivalent product and if at the end the follow-on version can substitute the reference product or can be interchanged which also needs head-to-head comparisons in patients to prove therapeutic equivalence and comparable safety.

Both the European Medicines Agency (EMA) and the US Food and Drug Administration (US FDA) have drafted reference papers and guidance's for the industry for several types of NBCDs, e.g. for iron nanoparticles products. Also regulatory science initiatives have addressed lacking investigations. For the comparability exercise the question stays to evaluate the totality of evidence for enough similarity of such test drugs with the reference product to conclude of the extent of comparability and its impact on use. Currently, the FDA follows a case-by-case approach for the evaluation of NBCD follow-on products, which is iterative, adaptive and flexible but also more general. The EMA on the other hand is supporting a class-related approach including non-clinical testing. A harmonized approach is, however, still missing.

References

Drugs

redpajama_set_name: RedPajamaWikipedia


text:
Asked: May 24, 20202020-05-24T19:21:16+00:00 2020-05-24T19:21:16+00:00In: Information Technology, Telecommunications
What is the difference between CSMA/CA and CSMA/CD?
Multiple Access protocols are the protocols used for the transmission of data between sender and receiver on Data Link Layer. These protocols are used when there is no dedicated link between sender and receiver, and Multiple Access Protocols decrease the collision and avoid crosstalk in these situations. Two of the protocols used as Multiple Access Protocols are CSMA/CA and CSMA/CD.
difference betweennetworking
Davies Level 1
2020-05-28T14:12:34+00:00Added an answer on May 28, 2020 at
CSMA (Carrier Sense Multiple Access) as the name suggests it is the protocol used to avoid collision by sensing the medium first before sending any data to the receiver.
Difference between CSMA/CA and CSMA/CD
CSMA/CD, carrier sense multiple access/collision detection, is performed at the media access control, MAC, layer. The collision is detected in CSMA/CD is through broadcast sensing. When the collision is detected, the transmission is stopped. Then the jamming signal is sent by the stations, upon which station wait for a random time and then transmits again. CSMA/CD is effective after the collision is detected. CSMA/CD is mostly used in wired networks. As it only detects the collision, so it only reduces the recovery time. In CSMA/CD, the data frame is set to resend after the collision is detected in the network. It is used in 802.3 standards. CSMA/CD is more efficient then CSMA, as it also has the collision detection feature.
CSMA/CA
CSMA/CA, carrier sense multiple access/collision avoidance, is also the network protocol used for carrier transmission and performed at the MAC layer. But unlike CSMA/CD, which only can detect the collision and after detection resends the packets, CSMA/CA has the ability to avoid the collisions. This is why CSMA/CA is effective before the collision occurs, as it can avoid the incoming collision.
CSMA/CA is mostly used in wireless networks. Due to its detection of the collision before the occurrence, CSMA/CA can minimize the possibility of collision. Unlike CSMA/CD, it first sends the intent for data transmission, and after a reply from the receiver, it starts the data transmission. It is used in 802.11 standards. It is mostly similar to CSMA.


Re: st: box and whisker plot with proportional box size?
Subject Re: st: box and whisker plot with proportional box size?
While this seems like a useful option, it can rapidly result in illegible graphs and crowded axis labels in the presence of groups of widely differing sizes. JMP does it, and I keep the option turned off by default.
If you want to give an idea of the amount of data in each group, then superimposing this as text on the graph might be more efficient.
What always seemed to me to be a better idea was giving some sort of display of the actual data points with a boxplot superimposed, or a little to one side, as you can do with Nick Cox's -stripplot-. This shows more and, of course, gives a good impression of the density of data behind each boxplot.
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Discussion in 'Education news' started by stonerose, Feb 8, 2019.
Have just read on TES site that there has been a trebling of 'refusal to teach' ballots in schools and it has become the second most common cause for concern among teachers. What a surprise - not.
Would like to hear Tessers' views on this.
A trebling? Well yes, that's strictly correct but a very misleading way of expressing the number of ballots. There were 3 in 2015 rising to 8 in 2017 and 14 in 2018.
TES don't say so, but surely it's only secondary teachers who put this as their second biggest concern? Seems unlikely that primary, where the majority of the profession teach, feel that way.
Pay and workload are serious but long term issues. Teachers deal with them, and plan to escape with greater or lesser success. Violently disruptive pupils cause intense immediate stress and can turn an effective days work into very little as well as affecting the education of very large numbers of other children, and of course triggering management into your classroom who may suggest that it's all the teacher's fault.
Mrs P left a job four years ago because the stress of dealing with a small group of inadequately supported poorly support 8 year olds.
I agree with @Rott Weiler that at the moment it is a very small sample size and not necessarily indicative of the size of the problem.
bevdex, stonerose, agathamorse and 1 other person like this.


Posted by Kathy S on December 14, 2015. Brought to you by yahoolocal.
Great place to stop in after a night of bowling, game of softball, or a couple hours of wallyball. Decent selection of beers at good prices and live club keno.
Posted by Bowling_Guru on December 20, 2014. Brought to you by yahoolocal.
Total Sports can be found at Production Dr 40501. The following is offered: Bars & Pubs. The entry is present with us since Sep 8, 2010 and was last updated on Nov 14, 2013. In Harrison Township there are 5 other Bars & Pubs. An overview can be found here.


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