>> What Product Should SKN Complex Develop Next?
I pay $2000 spotters fee for a unique idea I end up creating.
SKN Complex is doing really well thanks to your support! That's means I'm in a position to develop another product under the brand SKN Complex.
I'm currently conducting my own market research and looking at products all over the world for inspiration but I need your help.
Who better to ask for ideas than my customers and supporters?
I'd love to see an eye cream included in this range.I was contemplating cosmetic procedures before my sample of timeless arrived, so thank you thank you thank you SKN, not only have you saved me the expense but more importantly, precious time as well. I can achieve the rejuvenation I was looking for without having to drive for hours several times to a clinic, I don't have to leave home at all. I now look forward to the clock ticking by another brand new day means I get to use timeless again.
Good eye cream for sensitive skin/eyes?I'm lonikog for a good eye cream for a low price. I've read many good reviews about the yes to carrots one but that is a little high price wise for me. Though if it's actually that good then I'll buy it. But I would rather get something that is effective and good for sensitive skin/eyes for under 10 bucks.
Thanks for the feedback, its always great to hear customers liking our products. An eye cream is definitely in the pipeline for later this year and I'll be looking for people to test it for me, if your interested.
yes vikki, a good @ home facial for mature skin and younger. with lots of deep cleansing/ moisture, collagen stimulating, products.. also i have sparse eyebrows, does a eyebrow serum actually work? and also good eye cream, with a lifting ingredient?i would love to test many things, but age pension hard to do that, if just 1ar ok? thank you patricia hale.
I would love to see a really good hand cream that works, as you know when you get older your hands age and no matter how hard I try I can never find a good hand cream that not only helps dry hands but one that helps to tighten the skin on the hands. I think this would be a great product to work on. I have tried some of your products and they do work, so PLEASE try and work on the hand cream.
Thanks Maryanne. I'm with you on the hand cream its the part of my own body that really shows my age.
I have seen many cover up bruise,scar birthmark products,but I suffer a lot from broken capillaries especially on my upper cheast & some on arms & face.only laser treatment seems th be the answer,which is too expensive.The cover up products I have seen are noticableb on the skin.Iam embarrassed as I always get ask what is it that's on my chest.Tried Bio oil & spent on many products to no avail..Could you possibly look into something for this.
That is actually a tough one but I know that there are a lot of people who do suffer from the same thing so definitely one to put on the list for more investigation. I'd be interested to know what sort of products you have used, what sort of worked and what didn't.
I'd love to see a tinted moisturizer, with a reasonably high SPF, that actual smells pretty nice. Every day, I put on Sunscreen, then tinted moisturizer, then some sort of perfume, if you combined these, that would be so much easier and very convenient.
There is some tight regulations around the use of SPF factor ratings. If the products primary function is as a sunscreen then the product must be registered with the TGA (Theraputic Goods Administration) as a therapeutic good. To go through this process can be expensive and time consuming. But if the sunscreen is not the primary function of the product but its primary function is to moisturize or cover as in a foundation, then it doesn't need to be TGA approved. It will be classed as a cosmetic and can only show an SPF factor of 15, even if the product does have a certified higher SPF. Have you tried the tinted moisturizer from the Cancer Council, I'm sure what they smell like but I do agree with you that many do have that distinct sunscreen smell.
Always looking for people to try samples of products in early development so will definitely put you on the list.
I would like to see a slimmer, tiny head epilator for the face.
I have heard of a Foundation that comes out white and then it adjusts to your skin colour once on.Im not too sure of the name of the brand but i know its not available in Australia and i think a product like that would be great and exciting to try.I saw it been talked about in US beauty forums.Also would love to see a product that helps women grow back eyebrows quickly, like a serum or oil developed to help with sparse or over plucked eyebrows.
I know of one product that goes on white and then adjusts to your skin called Almay?? I have no idea how it works so will track it down and purchase it. Its interesting you mentioned eyebrows, our product Uberlash Eyelash Serum can be used on eyebrows as well so may be give it a go. But keep an eye out on our website as a product specifically for the eyebrows is already in the pipeline just not sure yet when it will be available.
this sounds interesting too thank you patricia [trish].
Many people suffer from allergies.
Create cream without perfume or coloring to minimize the risk of skin irritations and allergies.
Since the 70's-80's I have not seen a peel-off mask.I'm sure Revlon did one but didn,t last possibly because of the chemicals needed to set quickly and peeloff.I loved it used it alot more than current ones which are an extra to your cleansing routine in time and trying to get them off your face.I also agree with the Aged Care Nurse.An excoriation cream.The aged population is a bigger market than it ever has been before with specific needs.
I am always looking for a proper blackhead removal cream. I get them around my nose and they are realy deep in my pores. My nose also has lots of them and white heads. Ive tried lots of products with no joy.I have oily skin and am not sure if that makes any differance.
I'll put you on the list of testers Maureen.
Keep popping back to our website as you in the next few months you may just see an eyebrow serum product appear.
I AGREE WITH MAUREEN, RE: OVER PLUCKED EYEBROWS. YES I WOULD BE HAPPY TO TEST FOR YOU TOO, VIKKI, FOR MATURE SKIN. THANKS.
Products for Senistive Skin that Reduces Redness of skin.
All body allrounder to treat your body all over for reducing deposits of fatty skin.
A Nourushing product that can smooth your skin and feel refreshed and clean and healthy your skin to get all the toxins and deadskin away and make u feel ready and fresh 2 go again.
Maybe even a Body Butter Skin cream make your skin nice and soft and smelling refreshed again.
Your exfoliator is an interesting one and one that I have actually been working on. Up to now however I just haven't been able to get it right but I'll keep trying.
Oooooh Laina, that's an awesome idea. I second everything you've said. .
i am hoping that someone will bring back bed Sheet sets that have a bottom fitted sheet and a top sheet that has fitted corners at the bottom end…they used to be out when i was young but i have been unable to find them anywhere..
I have been using a facial cream from the USA that is an am/pm one called Hydroxatone. It is great and plumps out the fine lines around the eyes and other areas. My skin always looks fresh and I have noticed a big difference with lines around my eyes. People often comment on my skin and the clearness of it, although I do wear estee lauder foundation, but the cream compliments it beautifully as it is a nice rich one.
hi this is very interting to me tooo thank you vikki and joanne… trish hale would love this.
I know that every female out there goes through this if not once but twice but hundreds of times females have regrowth problems and either dont have the time to go and get the roots re done or they cant afford it. I dont know if there is but there diffenately is the need for a product that if you were getting ready togo out you notice that your roots needed doing. You dont have the time or the product to re do your roots. You whip out this product and either dust or cromb it through your hair and in minutes your hair is just like youve had you roots done at the hairdressers without having to leave the house.
i agree with robbie.. wqoul;d such a hairproduct, be available or can be made up? lots of us, can't afford hairdresse's prices.. thanks patricia hale great idea.
I have sensitive skin and roecesa, too. I started using Strivectin for fine lines and while it's too soon to see a difference, it hasn't aggravated my skin. I also use Aveda's Night Nutrients and Tourmaline Eye Creme (I've been using the eye creme for a little while now and can see a difference in the darkness under my eyes and the fine lines I'm starting to see).
Someone has already mentioned a cream to tighten the skin on hands and I think that is a great idea, but in addition I would like a fade cream that REALLY works to cover age spots on hands, lower arms, chest, and face. I'm 58 and fortunately don't have as much a problem with wrinkles as I do age spots. I already mentioned the idea of a fade cream for hands on your survey. My hands betray my age away and I'm very conscious of the age spots that seem to multiply every day!!
I would love to see an affordable cellulite cream that works.
l would like to find something that helps with cellulite, being a older woman cellulite is a problem as l still like to wear shorts.
I would love to see a cream to treat spider veins! I am only 20 and already I have large and clearly visible spider veins covering my legs! I know you can get saline solution injections at the doctors but I know mine will just continue to pop up in new places. They occur so quickly.
I have been a sufferer of chloasma(hormonal pigmentation) for about 10yrs after a doctor in the UK changed my pill and I went in the sun while on holiday. I have tried all sorts of products to try and lighten my pigment but it has never budged. I am currently using a cream from the dermalogist which includes hydraquinoe but as an ex beauty therapist I know it's not good for my skin long term. If you could develop a miracle cream to lighten my pigment on my forehead I would be forever greatful. I would Happily trial products for you.
I would like a cream for my hands that makes it look young and beautiful. I'm 44 and have very dry hands. This will be great and all woman would love it I know.
I,would also love to try a facial makep like max factors pancake makeup!!! mum, used to use it and she looked good @ 80yrs. With great coverage. i would love to try a product, like this, and see, if better than, mineral makeup, and usual liquid makeup. If you can, i would love to try it out for you as well, as eye creams, firming, uplifting product .. i have started using the restore, revive, youth cream, only 2 days yet, but feels nice thank you.. Vikki .. regards Patricia [trish] Hale.
Someone once made the comment that my face 'came alive' when I applied lipstick. I am fair skinned & freckle faced, so I do agree with that comment. But lipsticks don't stay put, & those that do, feel like they are powder coated. Yuk. I definitely would buy a product that actually dyes the skin on my lips. I know I can have my lips in-filled via tattoo, but oooh ouch! Short of having a good feed of Mulberries I know of no other way to do this. It wouldn't have to be a permanent dye, but one that would stay put for a week or so would be bonzaa!! I think this is an A-1 idea that many ladies would love.
I USE AVON MAGIX FACE PERFECTOR. IT'S A LIGHT, AS AIR, GEL-POWDER, THAT GIVES A NATURAL, FLAWLESS LOOK, KEEPING SHINE AWAY.C AN BE USED WITH, OR WITHOUT MAKEUP, DEPENDS, ON YOURSELF. IT FEELS, VERY LIGHT ON YOUR FACE.. VIKKI, HAVE YOU A SIMILAR PRODUCT? OR WOULD BE INTERESTED IN MAKING SIMILAR, PRODUCT?….. ALSO I HAVE CURLY, FRIZZY HAIR, SO I USE, ADVANCE TECHNIQUES, DAMAGE REPAIR, OVERNIGHT ELIXER. I JUST PUT A LITTLE IN MY HAIR @ NIGHT COMB THROUGH, AND IN AM ,FRIZZES HAVE GONE AND CURLS APPEAR. NOT EXPENSIVE EITHER. HOPE THIS HELPS YOU HUGSS PATRICIA [TRISH] HALE.
When we talk about creating new products, why not turn back the years? I am Bulgarian and I live in Australia. In Bulgaria I have an old book with different recipes. This book is 60-70 years. Some recipes for creams are very good.
I'd like to see something for the eyebrows. My eyebrows are somewhat asymmetrical and I have trouble getting my eyebrows waxed in the same shape.. I am tempted to shave them off, regrow them and then have them waxed in a more symmetrical shape. Something that would be useful could be something that stimulates eyebrow hair growth for women who want to renew or their eyebrows – maybe a peptide?
The other thing is maybe some sort of emergency fix stick on eyebrow for women who need to cope with asymmetrical or hairless eyebrows in the mean time?
A kit for getting the right eyebrow shape?
Another product I would be really keen to see come out is an eyedrop that clarifies and brightens the eyes. One that helps the eye white look whiter, and perhaps gives a healthier look to the coloured part of the eye. Maybe it could be moisturising and protecting? We do spend a lot of time in front of computers/UV….?
I am a natural redhead and have no colour in my eyebrows or lashes. I have had them dyed professionally and tried home kits. None seem to do a good job. I'm still left with patchy colour that doesn't stand out like mascara does. I woul like to see a mascara and eyebrow powder that gives the colour you want and gradually dyes the eyebrows and lashes slowly over time. If you created them i would be up for testing them. Cheers Jenny.
I would really love a cream to lighten or to make freckles disappear.I have had freckles all my life and nothing seems to do anything to make them go away.Im open to anything as long as it safe!


Have an interesting computer question or tip to share? Post your hardware or OS related issues here.
Chrome or Fire Fox How Do You Roll?
Do any of those "speed up your compute" programs work?
On or Off? Do You Turn Off Your Computer at Night?
Have you ever used Linux?
Need webcam Chicony DC-5132 driver?


If a loved one has to go into a care home in Northamptonshire, it can be an emotionally draining time for the family. We have set out some basic information on this page to help you out. We also advise on funding for care fees and whether your relative should actually be self-funding their care.


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Yemeni people won't accept Imamate, colonial schemes to return, says Defense Minister
Minister of Defense (Lt Gen) Mohammed Ali al-Maqdashi said " the national battle has been imposed by the insurgent Houthi militia in an attempt to bring history back that our great Yemeni peoples rejected and will never allow the Imamate and colonial schemes to come back".
His statement came as he chaired a meeting on Saturday brought together command of the joint forces of the armed forces.
General al-Maqdashi urged joining efforts and resources to counter Iran-backed Houthi militia coup and go on establishing the federal state. He said" The ongoing battle has been fought jointly by the Yemeni people and armed forces requires to unify all Yemenis and devote resources to achieve the major goals that include reinstate the legitimate authority and institutions and establishing the new federal Yemeni state"
The meeting aimed to discuss the combat operations in different battlefields.
The Minister of Defense voiced appreciation for the brethren in the Kingdom of Saudi Arabia and Command of the Joint Forces in the Saudi-led Arab Coalition for their support to the legitimate Yemeni government and people.

redpajama_set_name: RedPajamaCommonCrawl


Aleana's Bridal is your Bridal Shop near Fort Lee, Bergen County, NJ.
The sounds of wedding bells are just around the corner and you feel a bit of pressure to look your best on the day of the wedding. Finding the right gown instantly eliminates this pressure.
That is what we pride ourselves on here at Aleana's Bridal. We offer a great personal service to our Fort Lee customers to guide you step by step to select from a wide collection or to create the most wonderful custom gown for that special day.
Choosing the perfect gown is almost as important as choosing the right partner.
Are you tired of going into store after store and falling in love with parts of a dress, but always finding that it isn't exactly what you want? Do you find yourself obsessing over the color, but hating the silhouette, or loving the top, but hating the skirt?
We invite Mother of the Bride and Mother of the Groom to experience a couture gown making as well. If your moms are tired of shopping around and still could not find a dress that fits, we can help. We make sure that every woman leaves the store satisfied.
With a library of fabrics and colors to choose from, the possibilities for our mother of the bride and special occasion gowns are endless. We can perfectly match the bridal party color scheme if you prefer or we can create something completely unique and different.
As the second most important woman at the wedding, our one of a kind designs will make you feel like royalty.


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Navigation / GPS**, Heated Leather Seats**, Bluetooth**, USB Port / Input**, New Tires**, Accident Free Carfax History Report**, Up To Date Services**, Backup Camera, Premium Sound Package. Clean CARFAX.


Sibel Pensel - Deutsche Gesellschaft für Flöte e.V.
Sibel Pensel, ambassador of the French flute throughout the world, has just been decorated by the "Société d'Encouragement au Progrès" (which honors Nobel Prize winners, successful researchers and artists) on October 2016 at the "Ecole Militaire" in Paris.
She gives master classes and concerts in many countries such as Turkey, Russia, China, Corea, Japan, the United States, Brasilia, Ecuador and Europe. She recorded several CDs with the "Le chant de Linos" label.
She is invited as jury member for both Superior Conservatories' selections and "International Nicolet Flute Competition" in China, the International Biwako Flute Competition in Japan, the Terras de la Salette in Portugal, and the Varna in Bulgaria.
President of the French association "A travers la flute", she organizes flute festivals, and the renowned "International Flute Competition Maxence Larrieu".
Professor at the National Conservatory of Nice and the Bachelor's Degree, Sibel Pensel receives young talents of all nationalities.


It's not about how to fabricate it, it's about how to deliver long-lasting design.
Starting with your performance expectations, our commitment is that failure is not an option. We seek first to understand, then rapidly select and design from our own textile portfolio as well as from thermal materials available worldwide. As the authority on high temperature flexible materials, you can count on us to deliver more value than you first expect.
We don't just fabricate it. We understand it, we model it, we build it, and we show you how to install it, all with unrivaled speed and value.
Starting with our Technical Sales Team, we provide solution support and in-house design expertise for your thermal energy management challenges. Backed by our manufacturing and finishing versatility, along with our technical skillsets, we serve as a "one stop," time- and money-saving resource for our clients.
So whether you need a ready-made product from our catalog or a custom-made solution from our design and engineering team, our capabilities have you covered.
Precision fit means premium performance.
Our removable cover systems are designed to the shape and contour of your equipment. Excessive thermal energy losses are avoided with our 3-D cover designs that produce a tailored fit without gaps and hot spots.
Decades of experience deliver industrial sealing solutions for almost any high temperature application. From abrasion to chemical attack, let our years of experience and in-house custom textiles produce and deliver the best solution for your application.
From process to oven curtains to personnel protection, we manage the heat.
Combining mixed media of high temperature materials delivers best-in-class heat shields for thermal performance and durability.
While many fabricators produce only passive thermal insulation jackets, we take it to the next level with active heat trace cable enabled removable covers. From freeze protection to start-up and process control, we can maintain desired temperature set-points for nearly any industrial piping, pump, or storage vessel.
Your blanket is only as good as its installation system.
We select from a broad array of attachment and install hardware to survive the installation environment. Custom designed and fabricated installation hardware is common place in what we do to give you the best solution.
We'd love to discuss your company's thermal-related challenges and needs.


Karen and I attended the Brisbane Powerhouse last night to watch the musical What Rhymes With Cars And Girls? When people think musicals they might imagine scores of extra and massive production values. This musical had two performers on stage backed up by a band of three musicians telling a love story in an intimately sized theatre. Based on the album of the same name by Tim Rodgers (You Am I), playwright Aidan Fennessy has written a story that sparkles with witty wordplay and telling insight. Never more powerful though than when it echoes the struggles and dreams only too familiar to audiences. I loved it, and the two performers Johhny Carr and Sophie Rose at the centre of telling it.
Produced by Eyeball Media Enterprises Scenestr. is an online national magazine with local offices around Australia. With over twenty years of publishing history they've excelled at moving into the digital realm but they remain at heart from the streets. They still publish magazines in print for Perth, Adelaide, Sydney and Brisbane every month. If you're into music they're a great read but they do cover all of the arts including festivals, stand-up comics, fashion, theatre and film. It is the last two where I've been fortunate enough to do some coverage of which I'm very grateful.


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Clairevoyant (2021)
A yoga-practicing, chai latte drinking, incense burning rich girl hires a camera crew to document her journey to enlightenment as she attempts to attain nirvana and shed her ego. She embarks on a path of self-discovery – confronting her past, her painful present, and the oxymoronic Los Angeles spiritual scene as well as worldwide theology at large.
Director: Arthur De Larroche, Micaela Wittman
Quality: web
Download Download Download Download Download Download Magnet-URL EnglishWEB 720p Download Torrent EnglishWEB 720p Download Magnet-URL EnglishWEB 1080p Download Torrent EnglishWEB 1080p Download Download Download
Love Me, Love Me Not (2020)
Yuna and Akari are two high school girls with very different views on love: Yuna dreams about romance through rose-coloured glasses, while Akari is down-to-earth and practical. Meanwhile, high school…
Genre: Animation, Comedy, Drama, Romance, Upcoming
Somebody Up There Likes Me (2013)
Thirty-five years in the life of Max, his best friend Sal and a woman they both adore, Lyla. The trio stumble through mandatory but seemingly unfulfilling entanglements, at weddings, funerals,…
Sex After Kids (2013)
A disparate variety of couples from all walks of life strive to maintain active sex lives despite the notable distraction of having kids.
Nussa (2021)
Planning to impress his father who is coming home after being abroad for a year, Nussa the smart 9-year-old kid participates in his school's science competition. But when he receives…
Nerd (2019)
Blood Dolls (1999)
Virgil, an eccentric freak billionaire, spends his days being a "biological inventor." The "blood dolls," his newest creation, aid him in getting revenge on those who betrayed him.
Back to the Future Part III (1990)
The final installment of the Back to the Future trilogy finds Marty digging the trusty DeLorean out of a mineshaft and looking for Doc in the Wild West of 1885….
Genre: Adventure, Comedy, Science Fiction
Populaire (2012)
Set in 1958, Populaire focuses on Rose Pamphyle, who lives with her widowed father and is destined to marry a son of the local mechanic. Rose travels out of town…
Country: Belgium, France
BluRayHD
Pitch Perfect 3 (2017)
After the highs of winning the world championships, the Bellas find themselves split apart and discovering there aren't job prospects for making music with your mouth. But when they get…
9 Stacks (2021)
In a world where scamming is becoming the new normal, Randy gets caught up in a business fraud transaction. Now he's questioning whether he should do the right thing and…
Church People (2021)
America's youth pastor, Guy Sides, is stuck in the mega church marketing machine, and wants to find his passion again. Surrounded by sincere – but zany – church leadership, is…
I Got the Hook Up 2 (2019)
After best friends Black and Blue's restaurant is shut down, Black needs to find some cash — fast. He thinks his luck has turned when Blue's son, Fatboy, and his…


Congratulations! You did it. And it wasn't easy.
You recently stopped drinking. And you're ready to take on life with a sober mindset. But remaining sober is challenging when you're surrounded by alcohol.
You still want to go out and have fun. But you don't want the temptation pulling you in. You need ideas for sober activities that allow you to have a good time without drinking.
Luckily, you're on the right page. Stay tuned and keep reading to learn 7 fun things to do sober!
Going to a local theater to watch a movie or play is the perfect way to get your mind off of drinking. Watching a film or performance captivates your mind. And for that brief hour or so you become consumed in another world.
Think about what kind of movie you're in the mood for and see what's playing. And if you're worried about not having a friend to join you, then don't worry. You don't need the company to enjoy a good storyline.
It is absolutely acceptable to hit up the theater alone. It's a good way to enjoy some peace and quiet. And you'll have alone time while not actually being alone. You'll be surrounded by other moviegoers.
Attend a local sports game. Even if your hometown doesn't have a team in the NFL or NBA, it doesn't mean that there aren't small local leagues. See what smaller leagues play near you and purchase some tickets! It's also an excellent way to give back to the community.
If there are any colleges in your area, then look into their sports schedule to see what sports teams they have and when they play. These tickets are fairly cheap and they're just as exciting.
Not only should you consider attending your favorite sports game, but you should consider playing as well. If there are local sports leagues in your area, then sign yourself up! They would be happy to have you and you're sure to make a few new friends.
You might even find an adult sports league catered specifically to people who aren't recently sober. Do some research and see what you can find in your area. Playing a favorite sport gets your mind in the game and out of drinking.
If sports aren't your thing, then revisit an old hobby of yours. Maybe you once enjoyed painting or kayaking. Remember what used to make you happy, and read this blog for more info.
What do sober people do for fun? Enjoy nature! Talk a walk outside and breathe in the fresh air.
You can always hike down a nature walk trail. Nature trails are great for spotting wildlife in your own backyard. And if you'd rather not walk, then grab your bike or skates and cruise down the trail.
But don't limit yourself to nature trails. You can always observe and appreciate nature by simply stepping outside your door. Place a chair outside and watch the birds fly by and squirrels chase one another around a tree.
Nature is an amazing cure for just about anything. And if you're feeling down, then it's a great way to get into a better state of mind. It's nice to take a minute here and there to just relax and breathe.
Plan a day to visit a theme park! Theme parks offer you the thrills you love all while remaining sober. Now, this is how to have fun sober.
You'll be so focused on what ride to hop on next that you'll forget all about drinking. And don't feel discouraged if you don't have an amusement park near you. Arcades, game spots, haunted houses, laser tag, and more are all great ways to get in a good thrill.
Pick up some friends and head out on this mini vacation!
If you still really want to plan a day at an amusement park but don't have one around, then plan a road trip! Or, plan a road trip just because. You don't need a specific destination in mind. Just get in the car and drive. Enjoy the new scenery around you. And don't forget to stop and get out of the car to enjoy different cultures.
You should consider any type of traveling. Book yourself a flight to see relatives in another state. Or board a cruise ship for a week-long getaway.
Sober activities don't always involve physical activity. Schedule a day at the spa for a fun yet relaxing break. Go alone for some individual time.
Or plan a date with friends or your partner. If saving money is a priority, have friends over at your place for tea and pedicures! You can also try face masks and manicures, too.
Bring out the cucumbers! Have fun and get creative. And don't hesitate to ask your friends for some spa day suggestions as everyone might have their own spa preferences.
If you're not sure how to have fun sober, then you must try these sober activities. They're all a good way to take your mind off of drinking. And they can all be done alone or with friends.
For more on how to create a healthy lifestyle, head over to our blog for these great tips!


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July 23, 2011 / 11:13 AM
Video shows Beyonce, Jay-Z as cute couple
LOS ANGELES, July 23 (UPI) -- A new video shows some private moments among hip-hop stars Beyonce, Jay-Z and Kanye West during their recent recording stint in Australia.
The Los Angeles Times said the video is only 10 minutes long but gives fans a rare look at Jay-Z and Beyonce acting like a typical couple enjoying a quiet and fairly romantic dinner.
The video is a mini-documentary on the making of "Watch the Throne," a joint West and Jay-Z project. The action takes place at a Down Under estate that served as their headquarters.
In another slightly more offbeat scene, West presents Jay-Z with a large ring that is used to affix sealing wax to letters, much like European nobles used to sign their documents and dispatches centuries ago.
The Times said Beyonce is seen showing her man how the emblem on the ring is dipped in hot wax to form a seal, an apparently rare example of the interaction between two people who have kept their relationship largely hidden from their fans.
Music // 1 day ago
'Encanto' soundtrack tops U.S. album chart
Jan. 15 (UPI) -- The soundtrack to the animated movie "Encanto" is the No. 1 album in the United States.
Music // 2 days ago
Aespa's 'Black Mamba' music video passes 200M views on YouTube
Jan. 14 (UPI) -- K-pop stars Aespa had a first music video, "Black Mamba," reach 200 million views on YouTube.
CNCO teases 'new era' with 'Party, Humo y Alcohol' single
Jan. 14 (UPI) -- Latino boy band CNCO released a single and music video for the new song "Party, Humo y Alcohol."
FKA twigs releases 'Caprisongs' mixtape, 'Ride the Dragon' music video
Jan. 14 (UPI) -- FKA twigs released the mixtape "Caprisongs" and a playful video for the song "Ride the Dragon."
GOT7's BamBam shares 'Slow Mo' music video teaser
Jan. 13 (UPI) -- K-pop star BamBam released a preview of his video for "Slow Mo," a single from his EP "B."
Maren Morris to release third album 'Humble Quest' on March 25
Jan. 13 (UPI) -- Maren Morris announced on Thursday that she will be releasing her third studio album titled "Humble Quest" on March 25.
Lionel Richie to be honored with the Gershwin Prize for Popular Song
Jan. 13 (UPI) -- Lionel Richie is set to be honored with the Gershwin Prize for Popular Song from the Library of Congress.
Adele takes the stage in music video for 'Oh My God'
Jan. 12 (UPI) -- Adele released on Wednesday her new music video for "Oh My God," which appears on her latest album titled "30."
Mamamoo's Wheein shares 'Whee' highlight medley
Jan. 11 (UPI) -- K-pop star Wheein shared clips of "Profound" and five other songs from her solo EP "Whee."
The Weeknd fights his older self in 'Gasoline' music video
Jan. 11 (UPI) -- The Weeknd released a music video for "Gasoline," a song from his new album "Dawn FM."
Celine Dion cancels remaining dates on North American concert tour
Final episode of 'Watters' World' airs on Fox News Channel
Comic actress Tiffany Haddish arrested for alleged DUI
Kelly Rizzo remembers late husband Bob Saget as 'most incredible man on Earth'
Leslie Grace shares first photo of her in 'Batgirl' suit


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A View to Improving AMD and Vision Loss
| By Aaron Hudson, PhD, SCIEX
Credit: David Travis, Unsplash
Complete the form below and we will email you a PDF version of "A View to Improving AMD and Vision Loss"
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the US, but its disease mechanisms remain poorly understood and for many, treatment is suboptimal.1,2,3 However, new scientific approaches such as metabolomics and proteomics are shedding light on the causes of AMD and other eye diseases.3,4,5 These powerful modern methods are also revealing novel biomarkers that are leading to the development of new diagnostic, monitoring and predictive tools, as well as potential treatment options.6,7,8 These methods rely on advanced technologies that are constantly being improved, such as mass spectrometry (MS).
Investigating AMD disease mechanisms
As the name suggests, AMD is a disease that affects older people. It progressively destroys the macula, the part of the retina responsible for sharp, central vision (see Figure 1). Without central visual acuity, people are unable to perceive facial expressions, read, drive, and use a computer. The underlying causes of AMD are still not well understood, and as the main risk factor – aging – is not modifiable, research continues to investigate its disease mechanisms and how they can be targeted. There is no cure for AMD, but management options include drugs injected into the eye, lasers, photodynamic therapy and sometimes, even surgery.
Figure 1: Age-related degeneration of the macula results in the loss of central vision and visual acuity. Credit: Lei Zhou, Singapore Eye Research Institute.
The standard treatment for wet AMD (wAMD), a rarer but more severe form of the disease than dry AMD, is a drug that targets vascular endothelial growth factor (VEGF). This disrupts VEGF function in the formation of new blood vessels, which in wAMD, leak blood and fluid into the macula. However, reports of some patients still exhibiting vascular bleeding or leakage despite anti-VEGF treatment suggest that other disease mechanisms are at play, ones without VEGF involvement.3,9 Indeed, it has been postulated that AMD is a manifestation of a systemic disease.10
To better elucidate the mechanisms involved in age-related eye diseases, Professor Hannu Uusitalo of Tampere University, Finland, investigated the proteomes of healthy individuals of various ages without eye disease. With Dr Lei Zhou, Head of the Ocular Proteomics Platform at the Singapore Eye Research Institute (SERI), Singapore, he examined the proteomic profiles of tear samples, using advanced liquid chromatography mass spectrometry (LC-MS) technologies. The LC-MS scans were performed using SWATH Acquisition, an untargeted data-independent way to comprehensively detect all the proteins and peptides present in each tiny sample.5,8 Proteins related to inflammation, immune response, and cell death were found at different quantities depending on the person's age, which suggested that in healthy aging, cell growth and survival decreases while immune response and inflammation increase. These proteins could also help us better understand various age-related eye diseases.5
Identifying potential AMD biomarkers and treatments
Another researcher using LC-MS to investigate eye disease with Dr Lei Zhou is Professor Gemmy Cheung of the Duke-NUS Medical School at National University of Singapore (NUS), and Head of the Medical Retina Department of the Singapore National Eye Center (SNEC). With colleagues at NUS, SNEC, the Ocular Proteomics Platform at SERI, the Agency for Science, Technology and Research (A*STAR) Singapore, and the University of Colorado, USA, she is examining the metabolic profiles of serum samples obtained from wAMD patients. These LC-MS experiments were also performed using SWATH Acquisition, the label-free data-independent method for comprehensively detecting all the metabolites present in these complex samples.4,8
The comparison of serum metabolomes between wAMD patients and healthy individuals revealed that the patients had higher levels of certain molecules than the healthy controls, including glycerophospholipids, amino acids, and omega fatty acids.4 Another metabolomic comparison of sera from wAMD patients, this time between anti-VEGF drug responders and suboptimal responders, identified metabolites that differed between the two groups. Once again, the glycerophospholipid metabolic pathway was implicated as higher levels were observed in the suboptimal responders than in the responders. In particular, lysophosphatidylcholine may accumulate in the serum of suboptimal responders and thus interfere with vascular modeling and induce oxidative stress, resulting in a poor response to anti-VEGF medicines.3 These and other findings are forming the foundation for the development of a new clinical test, which will use LC-MS to detect and characterize metabolomic biomarkers for predicting which patients are likely to respond to anti-VEGF treatment.
LC-MS with SWATH Acquisition is also being used to measure the proteomes of individuals with wAMD. The study of vitreous proteomes led to the elucidation of a new pathway that contributes to the wAMD disease mechanism and excludes VEGF involvement. Unraveling this pathway identified further molecules and resulted in the discovery of a novel and potent anti-angiogenic factor. The active portion of this protein was isolated and synthesized into an investigational drug, which is being assessed in preclinical studies. Preliminary results indicate that this new experimental therapy may successfully treat wAMD, either as an alternative or in combination with anti-VEGF agents.
Proteomic biomarkers to predict treatment response in dry eye disease
MS-based proteomic studies have also been useful in the study of other ocular surface diseases, such as dry eye disease (DED) and glaucoma.5,7 In the healthy eye, the complex, extracellular fluid, commonly known as tears, is secreted from multiple sources, and serves to bathe the surface of the eye, to deliver and remove nutrients and metabolic products, to improve the retinal image, and contributes to the mechanical, antimicrobial and anti-inflammatory defense of the eye surface. In DED, the homeostatic functional unit of the lacrimal glands, one of the tear-fluid sources, is dysfunctional, resulting in an immune-based multifactorial disease of the ocular surface.11
Treatment for DED primarily involves artificial tears but in more severe disease, topical steroids, such as flourometholone (FML), or other anti-inflammatory drugs, such as polyvinyl alcohol (PA) are used.11 LC-MS based proteomic analysis of tears from DED patients undergoing treatment with either FML or PA revealed protein biomarkers that could be used to predict which patients would respond best to management with FML instead of PA. Further, potential biomarkers were also identified that may in conjunction with clinical signs provide a more accurate way of predicting whether a patient's disease severity would be moderate or severe.11
Tear proteome guides glaucoma patient stratification
DED can also occur with other eye diseases, particularly glaucoma. Although generally known as a disease of older age, glaucoma is also a leading cause of blindness in children, and the second leading cause of blindness in the world.12,13 Although there is no cure, there are drugs that can delay the glaucomatous deterioration of the eye, often by lowering the intraocular pressure – a common characteristic of glaucoma.7 Eye drops are the most common administration route, but prolonged use of topical glaucoma medication may induce the signs and symptoms of DED.
When this happens, switching patients from a medication containing preservative to a preservative-free drug can diminish adverse reactions.7 A study of the tear proteomes from glaucoma patients identified biomarkers that could potentially be used to detect which patients with glaucoma and concomitant DED would not respond to a switch to preservative-free medication, would have moderate improvement in symptoms in response to a switch, or would benefit the most from the medication switch.7
These are just a few of the ways in which metabolomics and proteomics studies using LC-MS with SWATH Acquisition are illuminating the disease mechanisms of eye diseases and how best to ensure that the right treatments are provided at the right time for the right patients. This is precision medicine, and you do not get precision medicine without the sensitive and precise quantification of molecules.6
Dr Aaron Hudson, PhD, is vice president, global marketing and strategy, at SCIEX, a Danaher operating company and a global leader in the sensitive and precise quantification of molecules.
1. Age-related macular degeneration (AMD) data and statistics. US National Institutes of Health (NIH) National Eye Institute. https://www.nei.nih.gov/learn-about-eye-health/resources-for-health-educators/eye-health-data-and-statistics/age-related-macular-degeneration-amd-data-and-statistics. Updated July 2019. Accessed March 2021.
2. Aged-related macular degeneration: facts & figures. BrightFocus Foundation. https://www.brightfocus.org/macular/article/age-related-macular-facts-figures. Published January 5, 2019. Accessed March 2021.
3. Gao Y, Teo YCK, Beuerman RW, et al. A serum metabolomics study of patients with nAMD in response to anti-VEGF therapy. Sci Rep. 2020; 10: 1341. doi:10.1038/s41598-020-58346-3
4. Chen G, Walmsley S, Cheung GCM, et al. Customized consensus spectral library building for untargeted quantitative metabolomics analysis with data independent acquisition mass spectrometry and MetaboDIA workflow. Anal Chem. 2017; 89: 4897–4906. doi:10.1021/acs.analchem.6b05006
5. Nättinen J, Jylhä A, Aapola U, et al. Age‑associated changes in human tear proteome. Clin Proteom. 2019; 16: 11. doi:10.1186/s12014-019-9233-5
6. Hagan S, Martin E, Enríquez-de-Salamanca A. Tear fluid biomarkers in ocular and systemic disease: Potential use for predictive, preventive and personalised medicine. EPMA J. 2016; 7: 15. doi:10.1186/s13167-016-0065-3
7. Nättinen J, Jylhä A, Aapola U, et al. Patient stratification in clinical glaucoma trials using the individual tear proteome. Sci. Rep. 2018; 8: Article 12038. doi:10.1038/s41598-018-30369-x
8. Jylhä A, Nättinen J, Aapola U, et al. Comparison of iTRAQ and SWATH in a clinical study with multiple time points. Clin Proteom. 2018; 15: 24. doi:10.1186/s12014-018-9201-5
9. Dugel PU, Koh A, Ogura Y, et al. HAWK and HARRIER: phase 3, multicenter, randomized, double-masked trials of brolucizumab for neovascular age-related macular degeneration. Ophthalmology. 2020; 127: 72–84. doi:10.1016/j.ophtha.2019.04.017
10. Cheung CM, Wong TY. Is age-related macular degeneration a manifestation of systemic disease? New prospects for early intervention and treatment. J Intern Med. 2014; 276: 140–53. doi:10.1111/joim.12227
11. Nättinen J, Jylhä A, Aapola U, et al. Topical fluorometholone treatment and desiccating stress change inflammatory protein expression in tears. Ocul Surf. 2018; 16: 84–92. doi:10.1016/j.jtos.2017.09.003
12. Personal story: Hannah Eckstein. Glaucoma Research Foundation. https://www.glaucoma.org/personalstories/personal-story-hannah-eckstein.php. Published 2019. Accessed March 2021.
13. Glaucoma: The silent thief of sight. University of Utah Health. https://healthcare.utah.edu/healthfeed/postings/2017/01/glaucoma.php. Published January 2017. Accessed March 2021.
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Q: Trying to delete specific items from a list within a list within a dictionary. (Python2) My data structures are as follows:
def cross(A, B):
    return [a+b for a in A for b in B]

digits = '123456789'
rows = 'ABCDEFGHI'
cols = digits
squares = cross(rows, cols)
unitlist = ([cross(rows, c) for c in cols] +
            [cross(r, cols) for r in rows] +
            [cross(rs, cs) for rs in ('ABC', 'DEF', 'GHI') for cs in ('123', '456', '789')])
units = dict((s, [u for u in unitlist if s in u]) for s in squares)
peers = dict((s, set(sum(units[s],[]))-set([s])) for s in squares)

This causes units to output
{'A1': [['A1','A2','A3','A4','A5','A6','A7','A8','A9'],
        ['A1','B1','C1','D1','E1','F1','G1','H1','I1'],
        ['A1','A2','A3','B1','B2','B3','C1','C2','C3']],
 'A2': [['A1','A2','A3','A4','A5','A6','A7','A8','A9'],
        ['A2','B2','C2','D2','E2','F2','G2','H2','I2'],
        ['A1','A2','A3','B1','B2','B3','C1','C2','C3']],
 'A3': [[etc.]]}

I want to be able to create a copy of units, but to not have the KEY be a string inside one of its own lists. So I want 'A1' removed from the first 3 lists. 'A2' removed from the next 3 lists, etc.
I can import copy and do units2 = copy.deepcopy(units) then units2['A1'][0].remove('A1') to do it one list at a time. So that led me to try making a loop to do it all at once.
for s in squares: #assign s to 'A1' then 'A2', etc.
    for x in range(3): #
        units2[s][x].remove(s)

I would think that this would do it flawlessly by running
units2['A1'][0].remove('A1')
units2['A1'][1].remove('A1')
units2['A1'][2].remove('A1')
units2['A2'][0].remove('A2')
# etc.

Unfortunately, after running this loop, I end up with:
units2 = {'B8': [[], [], []],
          'H1': [[], [], []],
          'C7': [[], [], []],
          'B3': [[], [], []],
          # etc.
          }

So somehow, this loop is deleting all of the data inside of the lists instead of just the current [s] in the current [x] list.
I have tried structuring the list in different ways and even made 81 versions of
for x in range(3):
    units2['A1'][x].remove('A1')
for x in range(3):
    units2['A2'][x].remove('A2')
for x in range(3):
    units2['A3'][x].remove('A3')

But I still end up with empty lists as all of my dictionary values.
*What I'm trying to do is build a sudoku solver to then use to generate sudokus for a game in PyGame. I plan on using the lists in units2 to check and see if only 1 cell in any given list is still eligible for a specific number. If that is the case, I know that that cell must have that number as its value because it is the only one in the column, row, or 9x9 block that can legally hold it based on the rules.

A: Using nested list comprehension change units to be:
units = dict((s, [[e for e in u if s != e]
                        for u in unitlist if s in u]) for s in squares)

A: If you look at what is happening here and step back for a moment, the answer becomes obvious.
You are no doubt aware what causes this:
In [1]: a = [1,2,3]
In [2]: b = a
In [3]: a.remove(2)
In [4]: print(a)
[1, 3]

In [5]: print(b)
[1, 3]

That's why you have copy.deepcopy. But when you look at what's happening, if you use Occam's Razor, the obvious answer is that you have multiple references to the same list, and when you delete from another list that ends out emptying all of the lists in your structure. Here's an easy way to check that:
import collections
import pprint

counter = collections.Counter()
for s in squares:
    for x in range(3):
        counter[id(units2[s][x])] += 1

pprint.pprint(counter)

Which outputs (unsurprisingly):
Counter({140502086261512: 9,
         140502086288328: 9,
         140502086261256: 9,
         140502086287688: 9,
         140502086288008: 9,
         # and so on...
         })

Obviously your ids will be different, but the counts will all be 9.
You also could've used pdb or pudb to inspect the variables as you looped through.
If you replace units2 with units you'll get the same counts. So the real question here is why doesn't copy.deepcopy behave the way you thought it did? And why do you have multiple copies of the same list in your list of lists?
Let's try a few experiments:
list_of_lists = [[1,1,1],
                 [2,2,2],
                 [3,3,3],
                 ]
deepcopy_of_lists = copy.deepcopy(list_of_lists)
print(id(list_of_lists))
print(id(deepcopy_of_lists))

I would expect two different id's here, and indeed they are. But what about their contents?
print(id(list_of_lists[0]))
print(id(deepcopy_of_lists[0]))

Yep. Those are different. What if we put these in a dictionary?
dict_of_list_of_lists = {'list_of_lists': list_of_lists}
deepcopy_of_dict = copy.deepcopy(dict_of_list_of_lists)
print(id(dict_of_list_of_lists['list_of_lists'][0]))
print(id(deepcopy_of_dict['list_of_lists'][0]))

We still get different ids. Everything seems to be behaving as expected so obviously we're missing something. Oh, yes - we're comparing between our copied lists and our original lists.

If you replace units2 with units you'll get the same counts.

There is a hint. Also, if you read the deepcopy documentation:

Two problems often exist with deep copy operations that don't exist with shallow copy operations:

*

*Recursive objects (compound objects that, directly or indirectly, contain a reference to themselves) may cause a recursive loop.

*Because deep copy copies everything it may copy too much, e.g., administrative data structures that should be shared even between copies.

The deepcopy() function avoids these problems by:

*

*keeping a "memo" dictionary of objects already copied during the current copying pass; and

*letting user-defined classes override the copying operation or the set of components copied.

deepcopy pays attention to objects that it has already seen.
mylist = [1,2,3]
list_of_mylist = [mylist, mylist, mylist]
deepcopy_of_mylist = copy.deepcopy(list_of_mylist)

print(id(deepcopy_of_mylist[0]))
print(id(deepcopy_of_mylist[1]))

Voilá! We have our culprit!
In your original dictionary units you have multiple copies to the same lists in different keys. An that's because of this line:
units = dict((s, [u for u in unitlist if s in u]) for s in squares)

This section in particular:
[u for u in unitlist if s in u]

You are repeating references to lists from unitlist throughout your dictionary. Luckily this is a trivial fix:
[u[:] for u in unitlist if s in u]

Will make a copy of that list each time, and the rest of your code will work just fine.
import pprint
import copy
import pprint

def cross(A, B):
        return [a+b for a in A for b in B]

digits = '123456789'
rows = 'ABCDEFGHI'
cols = digits
squares = cross(rows, cols)
unitlist = ([cross(rows, c) for c in cols] +
                        [cross(r, cols) for r in rows] +
                        [cross(rs, cs) for rs in ('ABC', 'DEF', 'GHI') for cs in ('123', '456', '789')])

units = dict((s, [u[:] for u in unitlist if s in u]) for s in squares)
peers = dict((s, set(sum(units[s],[]))-set([s])) for s in squares)

units2 = copy.deepcopy(units)
for s in squares: #assign s to 'A1' then 'A2', etc.
    for x in range(3): #
        units2[s][x].remove(s)

pprint.pprint(units2)

Outputs:
{'A1': [['B1', 'C1', 'D1', 'E1', 'F1', 'G1', 'H1', 'I1'],
        ['A2', 'A3', 'A4', 'A5', 'A6', 'A7', 'A8', 'A9'],
        ['A2', 'A3', 'B1', 'B2', 'B3', 'C1', 'C2', 'C3']],
 'A2': [['B2', 'C2', 'D2', 'E2', 'F2', 'G2', 'H2', 'I2'],
        ['A1', 'A3', 'A4', 'A5', 'A6', 'A7', 'A8', 'A9'],
        ['A1', 'A3', 'B1', 'B2', 'B3', 'C1', 'C2', 'C3']],
 'A3': [['B3', 'C3', 'D3', 'E3', 'F3', 'G3', 'H3', 'I3'],
        ['A1', 'A2', 'A4', 'A5', 'A6', 'A7', 'A8', 'A9'],
        ['A1', 'A2', 'B1', 'B2', 'B3', 'C1', 'C2', 'C3']],
 # and so on and so forth
 }

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I'm not sure what Ubuntu add printer feature wants to do when installing drivers but when I tried to add my Epson printer it didn't work. Most probably it tries to install the same driver as I tried above and it stuck on error: Unmet dependencies. Try 'apt-get -f install' with no packages (or specify a solution).
Let's install driver using dpkg. Download epson-printer-utility_1.0.0-1lsb3.2_amd64.deb from http://download.ebz.epson.net/dsc/search/01/search/searchModule (just search sx130).
Selecting previously unselected package epson-printer-utility.
Package lsb is not installed.


African American jazz composer Billy Strayhorn, who often collaborated with Duke Ellington and created an oeuvre that's shaped the history of American music, inspired David Roussève's new work, Halfway to Dawn. With a movement style integrating jazz, modern, and social dance, Roussève and his company give choreographic form to Strayhorn's music, as well as to his life in 1940s-'60s Harlem as a gay man and civil rights activist. An abstract work that incorporates video-projected text and art, Halfway to Dawn lifts Strayhorn's life into public consciousness through a theatrical dance performance that engages the heart. The performance is followed by a post-show Q&A.


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'We're both targets': Turbo prepares for Mbye centre switch
Dan Walsh NRL.com Reporter
Mon 8 Jul 2019, 04:27 PM
Tom Trbojevic says he is as much a defensive target as prospective centre opponent Moses Mbye as the pair look increasingly likely to square off with less than 20 games out wide between them.
NRL.com understands Mbye has trained at left centre in each of Queensland's field sessions ahead of Wednesday's decider, with Michael Morgan on restricted duties due to concussion protocols and a shift back to his old utility role increasingly on the cards.
Mbye has played his last two Wests Tigers games at centre, making for nine in total in what is regarded as the game's toughest defensive position across seven years of first grade.
By the same token, Morgan has started just the three Origins at centre in his career, while Trbojevic's stunning hat-trick in Perth came in his 10th outing at centre having played almost all his NRL career at fullback for Manly.
It was Mal Meninga who first returned the Sea Eagles star to centre for Australia at the 2017 World Cup, and in acknowledging the defensive pressure of the role Trbojevic expects both teams to look for points down his right edge.
"I think [Mbye] has played a bit of centre the last few weeks as well, but no it's not his first position either and he's going through the same transition as me and we're in similar spots," Trbojevic told NRL.com.
Maroons utility Moses Mbye. ©Scott Davis/NRL Photos
"We could target him, but they can also target me like that so it goes both ways. Those split-second decisions at centre, they can be the biggest in the game, so there is pressure in that sense.
"Obviously defence is the focus and that's what I work on the most going in there.
"Having such great players around me, especially Friz [Tyson Frizell] and Fergo [Blake Ferguson], that helps the most and makes my job easier."
NSW hooker Damien Cook meanwhile expects Mbye to handle the new role with aplomb, believing centre to be the Queenslander's best position when they played together at the Bulldogs.
"I played with Moses at Canterbury for a few years and I honestly believe that centre was always going to be his best position," Cook said.
"He played really well as a half at the Dogs and now he's been a fullback at the Tigers so he's obviously very versatile.
"He's a very strong ball-runner and he's got ball skills as well. He's strong through the body and I did always wonder if given the one-on-one chances you can get out in the centres, if he would go well given a run out wide there.
"But I think his ball-playing at times has kept him in the halves and those playmaker roles so I guess we'll see how he goes."
Turbo-charged Tom reflects on Origin hat-trick
Such is Trbojevic's own form on the Origin stage, Brad Fittler declared he simply had to get him into his game two 17 somewhere with James Tedesco occupying the No.1 jersey.
In turn Trbojevic was given a licence to roam in-field from right centre as a second fullback, the result being three tries all scored through the middle in the Blues' 38-6 romp.
The 22-year-old is more than happy to play wherever needed in representative teams, and says there are parts of Tedesco's game that just can't be learned.
"It's hard to pick up that freakish ability to be honest with you," Trbojevic said.
"At times you just sit back and admire him. The way he beats defenders, he's very gifted and I don't know if it can be replicated.
"You want to be the best player you can be. I play fullback and I want to be the best fullback, but right now Teddy's there and he's the best player in the game so I'm happy to work around him."
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Show up with the confirmation of the accreditation as well as an identity document for both accredited persons.
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Panel Discussion on Oregon Oysters
Oysters on ice. | Courtesy from Shuck Portland
In the early 1900s, the Oregon coast boasted vast wild oyster populations. A major resource for the state, the once abundant populations of wild oysters became victim to over-harvesting. Recently, few efforts to rebuild the state's native oyster...
Rally Against Offshore Drilling
February 6, 2018, Salem
Stop Offshore Drilling. | Photo courtesy of Surfrider Foundation
The Department of Interior announced plans on Jan. 4 to dramatically expand offshore drilling in U.S waters. The plan targets over 90% of all federal waters for new oil and gas lease sales including the Atlantic, Pacific,...
Offshore Drilling Public Meeting
Oil rigs and whale spout off the coast of California. | Photo by Al Seib (LA Times)
The Department of Interior announced plans on Jan. 4 to dramatically expand offshore drilling in U.S waters. The Trump Administration is targeting over 90% of all federal waters for new oil and gas lease...
February 6, 2018, Gold Beach
King tide, a preview of sea level rise, at Arizona Beach, near Gold Beach.\Photo by Leslie Suva.
Ryan Sandler, a meteorologist with the National Oceanic and Atmospheric Administration (NOAA) will discuss "Climate Change and the Pacific Northwest" at 2 p.m. at Southwestern Oregon Community...
King Tide Wrap-Up Party
February 5, 2018, Coos Bay
King Tide swamps railroad tracks in Coos Bay.\Photo by Robert More.
We're celebrating the conclusion of the 2017-2018 King Tide Project with a party on Monday, Feb. 5, beginning at 6 p.m. at the 7 Devils Brewing Co. in Coos Bay. We'll furnish the finger food—drinks and meals available no...
Talk on Ocean Acidification
February 1, 2018, Newport
Dr. George Waldbusser at work in the field.
Marine scientist George Waldbusser will address the crucial question of how ocean acidification caused by climate change will affect Oregon's coastal habitats when he speaks on "Ocean Acidification and Estuaries: Connections between Land and Sea,...
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Yaquina Head lighthouse, near Newport, uses energy--let's keep it clean.\Photo by Justin Knott.
Lincoln County residents who are interested in making a constructive effort to combat climate change are invited to learn about an ambitious state legislative bill proposed for the upcoming state...
Science Pub Features Pyrosomes
January 28, 2018, Coos Bay
Over the past year, you may have seen some odd gelatinous tubes (some compare them to icycles) washing up on local beaches. Many CoastWatchers have reported large numbers on their miles. These creatures are known as pyrosomes, and have never before been seen in such concentrations in...
Geologist Nick Cohn sampling the wind at South Beach.
We're celebrating the conclusion of the 2017-2018 King Tide Project with a party at the Rogue Brewery's South Beach location (2320 S.E. Marine Science Dr. in Newport). We'll furnish the finger food—drinks and meals available no host...
January 15, 2018, Cannon Beach
Aspiring coastal scientist Dylan Anderson.
We're celebrating the conclusion of the 2017-2018 King Tide Project on the north coast with a party at the Public Coast Brewery (264 3rd St.) in Cannon Beach. The event is free and open to all. We'll furnish the finger food—drinks and meals...


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Home » Gardening » Treating diseases and pests » Xylella fastidiosa, the olive tree killer
Xylella fastidiosa, the olive tree killer
Botanical name – Xylella fastidiosa
Common name – Olive quick decline syndrome (OQDS), Pierce's disease
Family – Xanthomonadaceae
Sub-species – fastidiosa, multiplex, pauca and sandyi
Type – Bacterial disease
Symptoms – leaf scorch, chlorosis, stunting, twig desiccation
Until recent times, Xylella fastidiosa wasn't mentioned very often, but nowadays it's become a major topic on the field. Discover all you'll need to know about this disease: where it comes from, how to prevent it, and knowing how to identify its symptoms.
What is Xylella fastidiosa ?
It is a bacteria native to North America. It has spread to Europa and has acclimatized around the Mediterranean. Initially, only a few outbreaks appeared in small areas, but Xylella fastidiosa has now reached epidemic proportions and is decimating orchards in Corsica and Southern Italy, in the historical olive-growing region of Puglia.
This bacteria is extremely difficult to contain because it can live on over 600 different plant species crossing over 80 botanical plant families. Among these host plants, you'll find:
fruit trees (olive tree, grape, orange tree, peach tree, coffee tree, cherry tree, etc.);
oak, maple and many other trees;
and even a series of smaller ornamental plants such as oleander and medick, for instance.
How does an infection occur?
Xylella fastidiosa attacks the plant's xylem. This layer in every stem, branch and trunk is in charge of ferrying raw sap up to the branches: water and minerals.
As it develops in this thin layer, the bacteria clogs the sap vessels up: nutrients can't make it to the top of the plant. In short order, the plant starts wilting and eventually dies.
Recognizing the symptoms
What makes Xylella fastidiosa particularly dangerous is that it is difficult to correctly identify the symptoms that are specific to this disease.
Indeed, the range of symptoms that this bacteria causes is very similar to symptoms of other diseases – even simply deficiencies in the soil. Additionally, some plants are asymptomatic, meaning they don't display any sign of infection even as contamination is underway. And of course, as they suffer from lacking nutrients or other diseases, some plants might technically display symptoms that seem due to this bacteria, but they're not infected at all.
In this situation, it's difficult to write up a list of accurate symptoms for Xylella fastidiosa. Nonetheless, depending on the plant, you can encounter:
leaf scorch, as if burned;
twigs and smaller branches drying out;
stunted growth;
yellowing and/or reddening of leaves;
leaf cholorosis (a phenomena normally linked to iron deficiency).
How does this disease spread?
Based on current knowledge, three modes of spreading stand out:
clearly the cause for the first infections was the importing, reproduction and planting of infected plants. This is one of the main factors explaining the spread.
In Europe, plant movement is restricted through a pan-European ordinance with reference 2020/1201. In France, a law dated from October 19th, 2020 transforms this ordinance into common law.
Sap-sucking insects also are vectors and spread the disease. Since they feed on the plant's xylem, as well, they also carry the bacteria with them. The contaminated area widens as they also move away.
Although not all insects have yet been identified, among the likely culprits are the many leafhoppers. The meadow froghopper (or spittlebug, Philaenus spumariushas) also been proven to transmit Xylella fastidiosa between plants throughout Europe.
Lastly, one means of infection isn't very often though of: gardening tools. They're also a route for many diseases to spread, typically such as fire blight, botrytis and phytophthora. This olive-tree killing disease also spreads through tools. Whenever you prune a branch, snip a stem or saw a trunk, bacteria latch on to the cutting blade. From there, they're ready to contaminate other plants if you're not careful.
How to treat against Xylella fastidiosa ?
Sad to say – as of today, there is no way to treat this disease. The only thing you can do is try to prevent its spread. There are quite a few steps you can take to do this. Nonetheless, if ever you notice one or more infected plants, laws and regulations recommend pulling out and destroying the entire plant. Also, if this happens, you should start observing other plants to see if they might be infected as well, checking out for early symptoms.
Preventing the disease from infecting olive trees
As we've mentioned, although sap-sucking insects are prime factors in spreading Xylella fastidiosa, our own garden tools are just as guilty. That's why it's crucial to disinfect all your tools every time you use them – even just as you're switching from one plant to the next, too! This is particularly true of cutting tools: secateurs, pruners, loppers, saws, chainsaws, tree saws…). Even more so if you live in a region where the bacteria has been located already.
To learn more, read:
Olive tree: the Mediterranean comes to the garden
Olive trees, even in the North!
Credits for images shared to Nature & Garden (all edits by Gaspard Lorthiois):
Leaf and stems dying by Fabien Piednoir under © CC BY-SA 4.0
Scorched leaf by jellyfishww under © CC BY-NC 4.0
Suffering already by Carolina P. under Pixabay license
Olive tree orchard, still safe from xylella by Rosalyn & Gaspard Lorthiois, own work
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Join the San Francisco community in welcoming 2015 with spiritual empowerment at Master Sha's Soul Healing Center on New Year's Eve.
Detracting from the norm of high caliber parties, while detoxing from holiday stresses, spiritually-conscious individuals are looking to close the year by connecting at the soul and heart level, and bringing in 2015 fully empowered for the rebirth of a new year. The Master Sha's Soul Healing Center is supporting the San Francisco community with a New Year's Eve program designed to help individuals experience a more reflective start to the new year by connecting soul to soul and heart to heart with each other and all of humanity – regardless of religious affiliation. Master Sha's Soul Healing Center is open to everyone on December 31st to provide many opportunities to offer their love, forgiveness, compassion and light to the world. Master Sha's Soul Healing Center is located at 1549 California Street, San Francisco, CA 94109. To register for upcoming events, visit http://www.lovepeaceharmonycentersf.com or call 415-971-7373.
World renowned Soul Healer Dr. and Master Zhi Gang Sha has Soul Healing Centers around the world to help individuals live healthier, more connected, more enlightened lives on a community level, while Master Sha connects to audiences on an international level. Master Sha's Centers seek to empower individuals to heal and transform every aspect of their life and to transform the world. "I have the power to heal myself. You have the power to heal yourself. Together, we have the power to heal the world," says Dr. and Master Sha.
Dr. and Master Sha has personally trained and selected Master Marilyn Smith, Master Peggy Werner, Master Robert Feda, Master Shu Chin Hsu and Master Shunya Barton as his Worldwide Representatives to lead and serve the San Francisco community. During this holiday season, Master Sha's Soul Healing Center welcomes everyone to experience the unconditional love, forgiveness, compassion and light available through events, blessings, meditations, teachings and support.
Join thousands of spiritually-guided beings for Dr. and Master Sha's annual New Year's Eve Blessing teleconference which is expected to bring together people from more than 50 countries. Dr. and Master Sha's extraordinarily uplifting one-hour spiritual ceremony is the perfect way finish the last few hours of 2014. During Dr. and Master Sha's New Year's Eve Blessings teleconference, he will lead individuals to chant to create love, peace and harmony and will bestow soul blessings to humanity, all souls, all animals, Mother Earth and all universes.
This sacred and secret practice is very ancient and practiced only by the highest level spiritual beings. Those in attendance will burn "yuan bao" (special sacred paper) to offer gratitude for all the blessings received in 2014.
Bring your favorite dish, snacks or beverages to share with others at this community gather. Please only bring non-alcoholic beverages.
Experience a truly uplifting and transformational meditation based on the teachings of Dr. and Master Sha, which guides individuals to transform any aspect of life for 2015. The Divine and Source share this guidance through Divine and Tao Channel Master Mirva to aid in individuals' physical and spiritual journeys for 2015 and for the Soul Light Era.
Please register for services in advance by calling 415-971-7373.
Master Sha's Soul Healing Center in San Francisco is honored to serve the community and to personally guide individuals in developing their soul healing abilities, opening their spiritual channels, and advancing on their soul's journey. These special holiday and new year programs are in addition to the Center's regular services and programs.
An international bestselling author, Master Sha is author of ten books in the Soul Power Series published by Simon & Schuster (Atria Imprint), with each book reaching the New York Times bestselling list and four of them reaching #1. Master Sha's Soul Healing Miracles book published in 2013 by BenBella was instant bestseller on USA Today and Wall Street Journal. His newest book, Soul Mind Body Science System was published November, 2014, landing on Amazon bestseller lists within weeks.
Dr. and Master Zhi Gang Sha's Soul Healing Miracles™ Chanting Channel fosters a soul healing community to learn and use chanting and soul songs for personal, spiritual, mental and soul development, 24/7. For more information about Dr. and Master Zhi Gang Sha, visit http://www.DrSha.com.


Enermax has really been upping their game with every iteration of PSU they release. Out of the unit's we have had on the test bench, each one has always incorporated improvements over the previous unit. Behold, Enermax's latest flagship entry the MaxTytan.
The MaxTytan is the new flagship range from Enermax ranging from 700 watts to 1250 watts. On the test bench we will be checking out the 1250-watt model, so our observations will be focused on it. The MaxTytan range of units all boast the coveted 80 Plus Titanium certification, which means they are guaranteed to have 90-94% efficiency at 10-100% load. The new MaxTytan lineup has been designed and built utilizing the very best components available and continues to build on past designs. Like previous units we have reviewed, the entire MaxTytan lineup boast 100% 105C Japanese electrolytic capacitors for improved stability and reliability.
Relying on past design success, Enermax has included its patented 140mm Twister Bearing fan. We had great results with this fan in the past, so it's reassuring to see it return in these new units. The MaxTytan still utilizes the company's familiar smart semi-fanless operation. Enermax has taken fan control a step further and has included its latest innovation dubbed the CoolerGenie. The CoolerGenie is a fan controller which connects directly to the motherboard, PSU, and 3 optional case fans. The unit has physical button for control, as well as a software component that allows the user to control fan profiles via a nice user interface.
The unit is fully modular, which is one small nit-pick we had on some early Enermax unit's, but this has all but been resolved. This unit is just packed to the brim with features and the great thing is that all of them are actually useful and impactful to the unit, operation and design. As such the MaxTytan also includes Enermax's Dust Free Rotation technology which allows the fan and unit to self-clean. Last but not least, the Enermax saw fit to include an active wattage meter on the back of the unit. While it may not be useful 100% of the time, it's really neat to be able to look behind your rig and know just how many watts your rig is pulling down.


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Joseph & Joseph + Bravura Architects Interiors Distillery Architects
Kentucky's oldest continually operating architectural firm
Kentucky Peerless Distilling Company
Kentucky Peerless Distillery
In this artisan distillery located in a restored 1912 tobacco warehouse, visitors can see where corn, barley and rye are delivered, milled, fermented and then processed through the custom-designed 26-ft. column still. Fourth- and fifth-generation descendants of Peerless' founder Henry Kraver, combine history and technology to bring back this esteemed brand.
The bourbon and rye are aged in another section of the building, then are dumped and bottled. The entire process, from grain to bottling, happens in this historic building.
550 S 4th Street, Louisville, KY 40202
Lexington, KY Office:
628 Winchester Rd, Ste 302, Lexington, KY 40505
© 2022 Joseph & Joseph Architects. All rights reserved.


The Steveston Cookie Company enjoyed providing delicious and beautiful decorated cookies to the Steveston community (and far beyond!) for ten years. Unfortunately we are not currently operational. Thank you for your interest.


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Karalio (Caralio) – polski herb szlachecki z nobilitacji.

Opis herbu
Na tarczy dzielonej w słup w polu prawym, czerwonym, lew wspięty, złoty, ukoronowany.

W polu lewym, błękitnym, feniks purpurowy, wyłaniający się z płomieni czerwonych, patrzący w słońce złote w prawym górnym rogu pola.

Klejnot: Pół lwa jak w godle.

Labry z prawej czerwone, podbite złotem, z lewej błękitne, podbite złotem.

Najwcześniejsze wzmianki
Nadany 29 kwietnia 1552 Janowi Jakubowi (Giovanni Giacobbe lub Giacomo) Caraglio z Werony. Caraglio pracował jako wyrzynacz gemm, uzyskał prawo do używania herbu jako znaku imiennego na swych wyrobach złotniczych.

Herbowni
Caralio – Caraglio – Karalio.

Przypisy

Bibliografia

Linki zewnętrzne

Herby z nobilitacji

redpajama_set_name: RedPajamaWikipedia


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T-Mobile Promises Nationwide 5G Network Coverage… Eventually
don't hold your breath
Image courtesy of Mike Mozart
5.2.17 12:26 PM EDT By Kate Cox@kcoxdc
don't hold your breath 5g t-mobile the future soon
Sure, your phone is kind of fast… but it could be faster. A lot faster. All of the big wireless carriers are super excited about the whole new network generation of fast, but there's a hitch: It doesn't exist yet. But that's not deterring T-Mobile, which is out there today promising to get you a nationwide 5G network while Verizon and AT&T are still pulling their metaphorical shoes on.
T-Mobile CEO John Legere and CTO Neville Ray made their promises today with a video and corporate blog post.
Legere began by singing the praises of the future — and, as he does, waving off and mocking the efforts of his competitors.
TL;DR Version
• T-Mobile's planning to start in 2019 and go nationwide in 2020…
• …because there won't even be a 5G standard until at least June 2018.
• …and by which point, everyone else will probably have caught up.
• Legere likes mocking Verizon and AT&T's limited trials, but they have reasons for what they're doing
"5G will be amazing, and we can't even imagine all the cool stuff it will bring, just like with our earlier network innovations," he said. "That's why truly mobile 5G has to be nationwide — period, the end."
Then, he mentioned AT&T's trial efforts, claiming to quote media that found AT&T's plan, "bull**it," "fake," and, "ruining 5G." He followed that up by mocking Verizon's statements that fixed 5G networks could be a reliable alternative for cable at home.
"Of course," he added, "that should be really fun to watch, because if there's anyone consumers hate more than the duopoly, it's probably big cable."
(He's not wrong: Consumers do, in fact, hate their cable companies.)
Legere then explained why he thinks AT&T and Verizon's high-frequency strategy sucks: "It's basically a series of hotspots," he said. "That's no solution for mobile 5G coverage!"
MORE: What the heck is 5G, anyway?
Ray echoed the sentiment in his blog post. "5G is going to be AMAZING — maybe the most transformative technology of our lifetime," he began. "Nationwide 5G coverage will drive endless possibilities, and yes, the future is kick-ass!"
Ray and Legere are alone in their enthusiasm for the 5G future. The wireless carriers and the FCC — both under former chair Tom Wheeler and also current chair Ajit Pai — are excited about the potential for pervasive, super-speedy networks.
But then Ray continues into a fact vs. fiction section that's a little misleading with its facts. Following Legere's lead, he bashes AT&T and Verizon's baby steps into 5G to date.
"Last week AT&T introduced #Fake5G," Ray says, "and tried to confuse consumers and distract from the fact that their network is losing to T-Mobile."
And on the other end, "Verizon is getting their ass kicked so bad in wireless they're banking on 'Fixed 5G' — wired broadband replacement one home at a time — to help them compete with the only companies people hate more than Verizon."
The first big problem with T-Mobile's promise is that there is no unified 5G standard yet. AT&T and Verizon are launching limited trials in certain hot-spots because they're still trying to work out what the best approach for their massive networks actually is — what works fastest, most reliably, at the least cost.
3GPP, the international consortium that hammers out and defines the technical details of mobile standards, is still working on 5G. In a February update, the group said that specifications for the first phase of 5G — the part where it actually has a logo and gets to be a real thing — will be ready in June 2018.
Ray acknowledges that, writing "As 5G standards are defined, chipsets are delivered, and equipment comes to market, we expect to be 3GPP certified and be able deploy 5G on clean spectrum … We'll expect all this to begin in 2019 and target 2020 for a full nationwide rollout."
This timeline, however, is almost certainly not unique to T-Mobile; most carriers are probably going to try to accomplish something similar, if 3GPP finalizes its specs when predicted.
Meanwhile, T-Mobile's repeated assertion that there is no "5G and not 5G spectrum" are true. You can build a next-generation network either at the low end or the high end of available radio frequencies that underpin all modern communications, or even some of the spectrum in between. Some of the chunks of spectrum the FCC has assigned to "advanced wireless technologies" are in the 600 MHz range that T-Mobile just bought a lot of, and some are in very high-frequency ranges previously considered unusable. Building a true national and international 5G network will require carriers to develop the ability to take advantage of all of it.
And while we're not usually in the business of defending Verizon from, well, anything, T-Mobile's implication that its competitor is foolish for trying to replace fixed broadband with 5G is a bit unfair. Millions of Americans still haven't been reached by decent — or any — home broadband. Running new wires to rural areas is expensive and logistically complicated; new wireless technologies may be the best hope for narrowing the digital divide, especially for folks who live in rural areas or on tribal lands.
So will it be exciting when T-Mobile does manage to develop and launch the first generation 5G network in 3 or 4 years? Sure! But by then it probably won't be as alone as its leadership claims to be.
Want more consumer news? Visit our parent organization, Consumer Reports, for the latest on scams, recalls, and other consumer issues.
5.2.17By Kate Cox@kcoxdc
AT&T To Start Using DirecTV Now To Test 5G Tech
what is this thing
What The Heck Is 5G Anyway, And Why Does It Matter?
the future is eventually
AT&T Will Test 5G Service In Texas This Year; Could Be Up To 100 Times Faster Than LTE
FCC Chair On 5G Future: "You Ain't Seen Nothin' Yet."
T-Mobile CEO Has No Idea What People Are Doing With 2 TB Of Mobile Data, Vows To Stop Them
Previous Students Claim For-Profit College Operator Deliberately Let Their School Fail
Next Is Wireless Charging Finally Coming To The iPhone?
Next Up: Is Wireless Charging Finally Coming To The iPhone?