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Roundtable on Sustainability From The Maldives to the World
Roundtable on Sustainability From The Maldives to the World As we figure out how our future world will look like, it is important that we do not lose a sense of perspective, in reference to the all-important 2030 Sustainable Development…
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From ESG to Sustainable Finance in Eurasia: Discussions at the St. Petersburg International Economic (SPIEF 2021)
From ESG to Sustainable Finance in Eurasia: Discussions at the St. Petersburg International Economic (SPIEF 2021) The Introduction of the ESG Taxonomy and Promotion of the Sustainable Development Goals in Russia and the Eurasian Economic…
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Uzbekistan and Europe Consolidate their Cooperation
Uzbekistan and Europe Consolidate their Cooperation On 9 April 2021, Uzbekistan became a beneficiary Special Incentive Arrangement for Sustainable Development and Good Governance (GSP+). The benefit of GSP+ is the removal of tariffs on…
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QazVac Vaccine Symbolizes Kazakhstan's Scientific Potential
QazVac Vaccine Symbolizes Kazakhstan's Scientific Potential On 26 April, Kazakhstan started rolling out its homegrown COVID-19 vaccine, QazVac. The start of this campaign fulfils President Tokayev's commitment to develop a Kazakh vaccine. QazVac…
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The Ring of European Friends extended to Central Asia
The Ring of European Friends extended to Central Asia On 29 April in Brussels, an event was held that few people have heard of, but it was nevertheless of enormous significance: within the European Parliament, the EU-Uzbekistan Friendship…
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Handover of the Peace Column to the International Club ICAA in the Foreign Ministry of the Federal Republic of Germany
Handover of the Peace Column to the International Club ICAA in the Foreign Ministry of the Federal Republic of Germany Handover of the Peace Column by the artist Ulrike Bolenz to the International Club ICAA in the Foreign Ministry of the Federal…
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Sheba signs 'breakthrough' deal to give diabetic care in UAE
Sheba signs 'breakthrough' deal to give diabetic care in UAE Sheba signs 'breakthrough' deal to give diabetic care in UAE The service will be provided by Sheba's Institute of Endocrinology unit, headed by Dr.Amir Tirosh,…
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AIBC Summit to Premiere in Dubai in Corona Response
AIBC Summit to Premiere in Dubai in Corona Response Due to the Corona pandemic Malta based SiGMA group already twice had to reschedule its flagship event AIBC Summit which then was scheduled to take place late April. It had to be rescheduled…
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5th CC Forum Held in Dubai
5th CC Forum Held in Dubai The 5th iteration of the CC forum "Global Investment in Sustainable Development" was held in-person in Dubai on March 31 and April 1, 2021. CC Forum has grown, in a very short time, into a leading platform where…
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Vietnam – opportunity, admiration and acclaim
Vietnam – Opportunity, Admiration and Acclaim World leaders, heads of international organizations and regional bodies congratulated and acknowledged the election of the leaders of the State and the Communist Party of Vietnam (CPV) announced…
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Diplomatic World Interview with Deputy Minister of Foreign Affairs and Director for EU Affairs H.E. Faruk Kaymakcı
Oman Celebrates 51st National Day of the Renaissance
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Don't just take our word for it, see it for yourself.
Browse through our portfolio to check out previous projects that we had been involved in.
This project utilizes a contemporary interior design concept, whereby sleek surfaces, crisp furnishings, and cutting-edge art are the key elements. These elements are combined with modern furniture which balance warmth and minimalism, thus providing a fresh and dazzling effect to the overall aesthetic.
On the other hand, timber paneling produces outstanding results, especially when used as walls for the living room. It provides a reliable, secure, and comfortable ambience to the space.
The living room should be a place where you can relax and entertain, regardless of its size.
Contrary to common belief, a small living room can be inviting and comfortable too. You simply have to choose the right colour, scale, and weight that can maximize the light and space. This will make the area look more spacious and roomier than it actually is.
With the right furnishings, you can transform your living room from a cramped and claustrophobic space into one that feels cozy and visually-pleasing.
Contemporary interior design emphasizes simplicity and cleanliness. The layout usually focuses on maximizing the usage of space through well-placed and detailed designs.
Therefore, if you want to include a piece of storage furniture but are concerned that it might spoil the overall aesthetic and balance, then a clean and uncomplicated line storage furniture is a recommended addition.
Using movie posters as decorations is a simple yet effective way to relive the Hollywood magic in your living area. It also gives a fun touch to your décor. You may want to consider investing in a home theater system as well to emulate a movie-theatre experience.
At Ataz Haus, we believe that every season has its own benefits yet can have different effects on your mood. Therefore, you can consider decorating your home with beautiful wallpapers that reflect your favourite season as this can ensure that you are always in a good mood.
One of the most commonly used materials – both in architecture and interior design – is wood. If wood is used in the right manner, it can completely transform a space to a whole new level.
Colourful furniture can be utilized to add life and warmth to a space. This simple addition adds comfort and just the right splash of colour to brighten up an area effectively.
After living in Shanghai for seven years, this cosmopolitan couple faced the daunting task of re-homing their belongings into a much smaller mansionette in Singapore.
They owned an eclectic collection of art and furniture, which they wanted to tastefully blend into a contemporary setting.
As one of our most unusual projects, we spent extra effort coordinating the design, material selection and construction with the client while they were still overseas.
When designing a home, additional storage areas are often overlooked for more exciting features. However, this seemingly unimportant attribute can make or break your quality of living once the home is completed. Having storage areas prevents your home from being messy and cluttered, thus ruining the ambience of the space. That is why when Ataz Haus designs a home, storage and your quality of life is always taken into consideration.
Not only can built-in storage spaces blend in with the walls, they can also double as decorative features. Nevertheless, it is highly satisfying to see your stuff disappearing behind smooth doors or slotted into perfectly-designed storage spaces.
If you're looking for a material theme that exhibits both vibrance and warmth, the classic combination of light wood and white is always a failproof choice. But what about accent colours? This post looks at two homes that pair their wood-heavy interiors with pastel accents to create a comfortable springtime ambience.
Combining a wooden accent with a pastel colour scheme will create a cozy and warm atmosphere. Besides that, the concept also makes your residence look modern without being overcomplicated.
Love staying in a luxurious hotel? Rather than staying in one, design your home to resemble a 5-star hotel instead! Ataz Haus creates the same vibe and atmosphere that attracts you to stay in a hotel, creating an ambience that is welcoming and relaxing which allows homeowners to feel devoid of any worries.
Arabian-themed design concepts are often found in Muslim homes and institutions. This style of interior design is known for adding a luxurious and elegant appeal to the overall aesthetics.
Arabian-inspired design concepts typically feature Islamic motifs, mosaic artwork, and inscriptions of the Arabic calligraphy. Other common elements also include polestar art, pottery, woodcraft, and luxurious materials such as ivory, marble, etc.
By using colours based on nature, you are able to create a welcoming and comfortable environment in your living space without sacrificing modern elegance. For example, to make sure that a room does not look too dark, choose to use light-coloured wooden floors.
Furthermore, colour combinations comprising of turquoise brown, cream, and brown-orange brown are the rage nowadays. This is because brown can also be paired well with gray and both these colours give off a cold and neutral feel, which is very popular in modern design concepts.
There's just something chic and cool about a home that features white and wood as its main theme. Sure, it is a simple idea but one that really speaks volume! White lends an airy feel that opens up your space while wood gives it an overall elegant and homely touch.
One advantage that the white-and-wood design concept offers is that it instantly brightens up your home, making the space look more spacious than it really is. Opt for lighter shades of wood – like the ones in the images – to give the space a modern look. Complement the concept with minimalistic furnishing for a simple yet elegant finish.
The false ceiling – equipped with hidden light fixtures – used in the living room gives this space a contemporary look that befits a modern home. The backlit TV feature wall acts as a central focal point for the space, immediately drawing visual attention with its grandeur appearance.
Dark and earthy tones are also utilised to create a warm and cosy ambience throughout the home. The colourful posters add a vibrant pop of colour without going over the top.
The living room is the main space that guests see when they step into a home, therefore it should be designed to impress. The off-white shades give this living room a bright and welcoming ambience. The living room also features minimal furniture and furnishings to make the space appear bigger and more spacious.
As for the bedrooms, earthy tones like brown and gray are used abundantly to create a cosy environment which promotes rest and relaxation. The elaborate paintings provide the perfect finishing touches to complete the modern-concept bedrooms.
Gone are the days of cubicles and enclosed spaces in the workplace. For this office space, wood finishing is used generously to give off a friendly and approachable vibe. The elaborate feature wall adds visual appeal to the entire space. Brown and black are colours which are often associated with subtlety, therefore they are used as the main colour schemes to promote a calm and relaxed environment to work in.
EcoParadise is a sports therapy treatment centre which has been in operations in Singapore for more than 10 years. Their newest outlet, situated near Aljunied MRT station features a Modern Muji theme, a tribute to the centre's Japanese origins. Moreover, the design also focuses on incorporating natural elements to create a soothing and zen ambience. Modern furniture and decor were also added to create a young vibe that will appeal to the younger crowd.
At Ataz Haus, we believe that a home is more than just a living space; every home has its own story to tell and we are the authors that help to tell the story with our design concepts.


Bringing routine to some of the repetitive tasks of our everyday lives does have the advantage of simplifying them and, in time, allowing us to perform them on auto-pilot. However, it also has the disadvantage of making the task mundane and ordinary which can lead to us becoming stressed through boredom. Try breaking some of your everyday routines, even on a temporary basis. Examples may include altering your route to work, sitting on a different chair in your living room or trying something different for breakfast. You may find that even a small change can reduce your risk of mundane stress and bring on an energy boost.


The coins of Bhutan have a unique character unmatched by most currency. Add a pop of sterling to frame the copper coin and you have a conversation piece that will go with every outfit in your closet.
Click the button below to add the Bhutanese Copper Coin and Sterling Silver Necklace to your wish list.


Terms and conditions: Terms and conditions at the Focus Trust reflect those found nationally.
Pensions: The Focus Trust contributes to Teachers' Pensions and Local Government pensions in the same way and with the same level of contribution as local authorities.
Employer Relations: The Focus Trust has a Trade Union agreement which recognises the teacher and support staff unions. This is further supported by an ongoing and productive relationship with key trade union officials.
Equality of opportunity: The Focus-Trust is an equal opportunity employer, dedicated to a policy of non-discrimination in employment on any basis including age, gender, race, colour, nationality, ethnic origin, disability, gender, religion, age, marital status, sexual orientation and/or medical condition.
Links with Focus Education: Focus-Trust has strong links with Focus Education and staff members benefit from all their latest publications, training and consultancy.
All the academies within the Trust are willing partners who have actively chosen to join the Focus-Trust and there is a very high degree of consensus, cooperation and commitment from within the group. Each of the academies within the Trust is autonomous and has their own distinctive ethos which meets the need of their community.
From the outset, a half termly Leaders' Forum (attended by Principals and their Deputies) has met. The purpose of the Leaders Forum is to deal swiftly with operational issues and focus mainly on pedagogical/educational issues. This has enabled a great deal of sharing of best practice from within the academies. Staff benefit from the opportunity to link across a wider community of diverse academies.
All of the above forums have enabled staff at all levels to benefit from enhanced professional development and mutual support.
The Trust runs its own programme for the induction of newly qualified teachers. Focus-Trust now offer a school-based Primary PG Teacher Training programme here in the North West in conjunction with Cumbria University.


Hey y'all! I'm SO excited to finally be part of the forum! I've been a huge CW fan for five years now, and I've been trying to join the forum for a long time. My favorite album/DVD is Believe, which may or may not have something to do with the fact that it was the first one I saw. I completely adore all the current girls, but Mairead N and Lisa L will always be my faves.
Welcome to the forum, Rachel! Did you see Máiréad Nesbitt's show with the Scariff School students last December? It was just outside of what I presume is your zip code. You're also really close to Evermore Park, which is awesome (besides the amazing costumes and buildings, former Celtic Woman members did the soundtrack for it).


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First look at the new Perry Mason HBO show
ALSO: Meet Karen and Barry Mason: wholesome American porno merchants
The first teaser for HBO's upcoming Perry Mason TV series has been revealed. The show is based on the book series written by Erle Stanley Gardner. Gardner wrote 82 Perry Mason books, many were adapted into episodes of the Perry Mason TV show.
New streaming service Peacock is set to launch in the US. It is NBC trying out it's own branded streamer, but with strong cable TV ties the network will be creating a deep link between cable TV and this new service. When it launches, Peacock will only be available to Comcast Xfinity cable subscribers. Later in the year, from July 15, the service will go wider with Peacock opened up to everyone (everyone in the US, that is). There will be three versions available to subscribe to:
A free, ad-supported version.
Peacock Premium with ads for $5 a month. This will have everything the free version has, but with a much deeper library of older TV shows and movies.
Peacock Premium without ads. This is what it says on the tin.
The Xfinity preview of Peacock won't launch with much new content, but instead concentrate a vast library of titles including episodes of 30 Rock, Parks and Recreation, and Frasier (The Office won't be available till later). The new titles coming in this preview period are mostly kid-friendly animated series, such as new episodes of Curious George and all-new series Where's Waldo? and Cleopatra in Space. Peacock Premium, the paid version of Peacock with bonus features such as exclusive next-day access to currently airing shows, will also feature episodes of currently airing series such as Law & Order: SVU, Blindspot, and Chicago P.D. To Xfinity customers, Peacock Premium is free; when Peacock debuts to the general public in July, it will cost $4.99 a month with ads and $9.99 with no ads.
Read more about the launch: Polygon
[Of course, if there are any Comcast subscribers reading this who can help me out with a login, please drop me a line by replying to this email.]
The Eddy is a new Netflix series from Whiplash / La La Land director Damien Chazelle. It's a musical drama set in the jazz world of modern-day Paris and stars Andre Holland. I'm keen to check this out when it debuts on May 8.
There's an interesting-sounding doco landing on Netflix next week. Circus of Books is about Karen and Barry Mason, a straight, mainstream couple. They sent their kids to a religious school and never talked about work with friends and family. What was that work? For 35 years they ran the gay porn shop Circus of Books and were the biggest distributors of LGBT porn in America. The doco also delves into why Karen acted so negatively when one of her three kids came out.
Interesting stuff. You can see it on Netflix from April 22.
Censorship on Disney+: Exposed like Daryl Hannah's bottom
Disney plans radical changes!

redpajama_set_name: RedPajamaCommonCrawl


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Home Stocks MannKind Corporation Names Hakan Edstrom New CEO
MannKind Corporation Names Hakan Edstrom New CEO
Vikas Shukla
MannKind Corporation shares plunged as much as 3.78% to $5.54 on Monday after the company announced that its founder Alfred Mann has stepped down from the position of CEO. The company board has appointed Hakan Edstrom as its new CEO, effective immediately. Mr Mann will become executive chairman. He will remain engaged with the biopharmaceutical company in business matters, including financing and development of its future therapies.
Edstrom has been with MannKind since 2001
Hakam Edstrom joined MannKind in 2001 as its president and chief operating officer. Even after assuming the role of CEO, he will continue to act as president. Before joining MannKind, Edstrom worked with Bausch & Lomb. Hakam Edstrom said in a statement that he was "honored to succeed Al." His appointment comes at a time when MannKind is gearing up to launch its first drug Afrezza in the first quarter this year.
The USFDA approved Afrezza in June last year. In August, MannKind reached a worldwide licensing agreement with Sanofi to market Afrezza. Under the terms of the deal, MannKind received $150 million upfront payment from its French partner, and stands to receive up to $775 million in various milestone payments linked to manufacturing, regulatory and sales milestone. Last week, the company received $50 million from Sanofi in the first milestone payment.
MannKind to present at JPMorgan Conference on Jan.14
The Valencia-based company will also get a share of profits from the sales of Afrezza. MannKind's diabetes treatment uses its proprietary Technosphere formulation technology. The company looks to develop other therapies enabled by the Technosphere platform. Success of Afrezza will be key to MannKind's future. Analysts estimate that the drug could generate more than $3.65 billion in annual sales by 2025. But Afrezza will likely cost more than the traditional insulin injections, which could hamper its sales.
On Wednesday, January 14, the company will present at the JPMorgan Healthcare Conference in San Francisco. At the event, MannKind is expected to provide further details on Afrezza launch.
Updated on Sep 27, 2020, 5:58 pm
Afrezza
Alfred Mann
MannKind
http://vikshukla.com
Vikas Shukla has a strong interest in business, finance, and technology. He writes regularly on these topics. - He can be contacted by email at [email protected]
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The Ho Chi Minh City People's Committee recently commissioned the transport department to introduce the new bus route.
A new luxury bus service running from Tan Son Nhat International Airport to Vung Tau will launch this month, VnExpress reports. The bus will operate from 12am to 11pm every day, with a schedule consistent with flight times.
The new bus will be equipped with Wi-fi and air conditioning. Assistance regarding flight booking, check-in and luggage will also be provided, according to the news source. Ticket prices, with insurance included, are expected to be VND180,000 per person. The service will be available to both local and foreign passengers.
Saigon authorities are hoping that the new bus service will help alleviate the chaos at the airport often created by private transport businesses, especially with the New Year holiday and Tet approaching.
The new service will also act as a pilot phase for a larger proposal. If the operation goes smoothly, the transport department will propose adding more routes from the airport to different cities and provinces.


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Title of the Mix
This is the introductory text of this mix, which, before listing the songs (below), offers a few facts about them, such as the sad truth that the Free Design (track 3) had only one moderate hit, "Kites are Fun" (#33 on Billboard's Adult Contemporary charts, and #114 on the pop charts), or the happy fact that there are three Monty Python-affiliated songs here, one (8) from Monty Python's Contractual Obligation Album (itself a "meta" title), another (20) from Monty Python Live! At City Center, and yet another (24) from the Original Broadway Cast of Spamalot. These sentences might also point out that since all "Python" tunes feature different performers, the three songs do not violate the mix-maker's unwritten rule of never including two songs performed by the same artist. However, the rather dull nature of this observation renders it unlikely for inclusion here. Of perhaps greater interest might be the information that the Beatles' (16) publishing company was "Northern Songs Ltd.," and that George Harrison wrote this one. Or that, while not actually the shortest song in the universe (12), the track by that name appears on Sandra Boynton's book-and-CD combo Rhinoceros Tap.
Update, March 2019: since we're no longer allowed to post mp3s via an interface, I have mostly recreated this mix on Spotify. (It is nearly all of the original mix plus several additional tracks — most of which are mentioned in the paragraph [scroll down!] acknowledging omissions.) Here's the new version, followed by the original track listing.
Original track listing below:
1) Title of the Song DA VINCI'S NOTEBOOK (2000) 4:27
2) Gotta Sing High KENNY WHITE (2010) 4:47
3) 2002 – A Hit Song THE FREE DESIGN (1969) 2:43
4) Hit Song DJ FORMAT featuring ABDOMINAL (2003) 4:45
5) Overnight Sensation RASPBERRIES (1974) 5:37
6) Top Forty MOSE ALLISON (1987) 4:23
7) A Happy Song MICHAEL FLANDERS & DONALD SWANN (1959) 2:01
8) One of Those Songs THE KING'S SINGERS (1980) 2:20
9) The Hut-sut Song THE MERRY MACS (1941) 2:35
10) Happy Working Song AMY ADAMS (2007) 2:10
11) The Shortest Song in the Universe ADAM BRYANT & MICHAEL FORD (1996) 0:47
12) Bass Man JOHNNY CYMBAL (1963) 2:32
13) Who Put the Bomp (in the Bomp, Bomp, Bomp)? BARRY MANN (1961) 2:47
14) Number Three THEY MIGHT BE GIANTS (1986) 1:28
15) Only a Northern Song THE BEATLES (1969) 3:25
16) Look What They've Done to My Song, Ma MELANIE (1971) 4:03
17) The Folk Song Army TOM LEHRER (1965) 2:12
18) How to Write Ultimate Protest Songs CITIZEN FISH (1990) 2:54
19) Protest Song NEIL INNES (1975) 4:10
20) A Road Song FOUNTAINS OF WAYNE (2011) 3:04
21) Fountains of Wayne Hotline ROBBIE FULKS (2005) 5:29
22) Velvet Underground JONATHAN RICHMAN (1992) 3:29
23) The Song That Goes Like This CHRISTOPHER SIEBER, TODD ELLISON & SARA RAMIREZ (2005) 2:54
24) Atheists Don't Have No Songs STEVE MARTIN & THE STEEP CANYON RANGERS (2011) 3:51
It's highly unlikely that any omitted "meta" songs would be mentioned here, in this concluding paragraph, because that would deprive the listener of the fun of pointing out the mix's inexplicable failure to include the Axis of Awesome's "How to Write a Love Song," Simon & Garfunkel's "Song for the Asking," Howard Jones' "New Song," Elton John's "Your Song," the Four Tops' "It's the Same Old Song," or Sammy Davis Jr. and Dean Martin's "Sam's Song," to name but a few. It's much more probable that these words would indicate that "Number Three" (15) appeared on They Might Be Giants, They Might Be Giants' first album (also known as the pink album), or that "A Happy Song" (7) is one of three "Songs for Our Time" on At the Drop of a Hat.
Underlined text, indicating that posts below might be of interest:
First and most relevant post (4 Sept. 2010)
The second (13 Sept. 2010), third (23 June 2013), and fourth (10 May 2014) posts — all less explicitly relevant than the first one.
March 31, 2015 · Filed under Metafiction, Mixes, Music


This unique elective is designed to develop camper's leadership, communication and teamwork skills. Campers will face challenges as a whole group and in smaller teams as they take on challenges such as fire building, bouldering, shelter building and raft building. Our outdoor pursuit activities and team challenges promote teamwork, cooperation and independent thinking.
Campers will face challenges to test their ability to problem solve, work together and communicate. The team challenges are engaging to test campers to their limits. The challenges give campers the opportunity to develop their leadership skills by helping to lead the group.
Learn to master the art of archery from our instructors. Learn the basics of how to hold the bow and 'knock' your arrow. Take part in different archery challenges to test your skills.
A highlight of the week! Get the chance to test yourself on the high ropes course and jump off the zipline!
A chance to get into the woods and learn to build a shelter! Work together and put your survival skills to the test.
Work on your climbing skills on our bouldering wall. Develop different climbing techniques to help you progress and develop your climbing skills.
Learn different techniques in fire-building. Learn the difference between building a teepee fire and a log cabin fire. A great survival skill to have!


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With almost 100 5-celebrity evaluations, this lying loveseat is touted for its comfort and ease, durability, look and easy set up. In addition to soft, but encouraging cushions, it provides a gliding system, so you can put your feet up and rock and roll (although, not at the same time.) Upholstered with extremely-durable bonded leather-based, this reclining loveseat will resist tears, releases and stainswhich is a great factor, because it also includes a storage compartment system (where one can hide your snacks, of course) along with a two-cup owner. Regardless of whether youre deciding set for a Netflix binge or watching football with your team, this reclining loveseat provides the durability and comfort without breaking the bank.
This sofa is praised for unique design and luxury. Its striking pazazz-arm sofa with seats offers you maximum room for stretching out and relaxing in your living space. So generally the contemporary sofa chaise increases the beauty of this established. The set also includes pillow top arms padded back again and chairs for optimum comfort. The sofa also includes a corner-obstructed wood frame that provides the sofa enough toughness. The sofa measures 89 in . wide by 62 in . thorough x 4 in . in height which makes it ideal for moderate dimension rooms. You may need to do small putting together eg from the thighs.
Whilst the rear of this couch hints at the Chesterfield, using its rows of tufting, a tux couch has cleaner, much more angular lines. It is stated to have been the bellwether of more contemporary designs within the 20's. While some say this couch design took its title from Tuxedo Park in Ny, it's also considered called after the classic extravagant mens suit. You can determine a tuxedo sofa by its hands that are identical height because the back. The tufting on the back of the couch and its rectangular outline will also be traditional qualities. Soft cushions include comfort for this high-equipped style. Also, as the sofa over from Upcountry is padded in leather, this popular style is often completed in textiles of all kinds, such as the really trendy velvet.
You cannot talk about this sofa with out talking about its impressive design, durability, and comfort. If you ever needed an appropriate seat, then move fast and obtain yourself Coaster Samuel Collection Cream Leather Sofa. You'll like it. This 3 seater sofa has clean outlines and great soft cushions. The cushions are affixed to the chair and at the back. It is made from leather and that is a certain wager that it is durable. It also features tufted back again and seats that certainly adds to its remarkable appear. More to the point, it features a springtime base that provides the necessary comfort and durability. Its wooden body makes it really durable. The long and the short of it is that this sofa is remarkable in every aspect. You may or may not agree with this. But the only way you can appreciate this is to find and try it.
This group of RTA couches is available in different furniture smoothness. A number of them include bonded leather-based, linen, corduroy, bed linen texture, polyester. All you need is to find the right tapestry in importance for the balanced requirements. Accessible supplies provide an simple-to-clean element. A attribute that implies its adaptability to face up to food and drinks. The extravagant chair and back cushions election in support of a cutting-advantage appear. The sq . shaped arm that begins just over them enhances the elegance. You will find the conveniences and soft styles that hit your entry.
If the Chesterfield is the elegant man amongst sofas, the Cabriole may be the grandes dame. Noted for its uncovered wood and elegant legs, reminiscent of the Louis XV time period, the cabriole also offers a unique silhouette. It was also a well-liked shape in the function of Rossana 2 Piece Coffee Table Set producer Thomas Chippendale. Usually, the back is one continuous item with out cushions and it has a stylish curving line. This particular cabriole version consists of gems in the tufts for added glamour. It's a couch design that can be as simple or opulent as you wish. Upholstered with a luxury materials like purple velvet produces a significantly various style sensation than whether it had been upholstered inside a more moderate, textural neutral. The main feeling of elegance derives from its overall shape and lithe legs meaning it'll always give a refined atmosphere to a room.


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MUSIC PLAYLISTS TO CHECK OUT ON SPOTIFY THIS APRIL
by REEF OMAR April 12, 2018
Are you ready for a month full of music phenomenon? There are three different musical talents heading to Malaysia in April 2018. So whether the plan is to dance to the beat of famed DJ, Zedd; expressing some love for pop/alternative band OneRepublic; or rock on to the sound of legendary German-born metal band, Helloween, Spotify has got you covered!
No matter the genre, Spotify has curated playlists from the most diverse set of musicians you can think of.
Here are some playlists to complement your music experience this April:
● Zedd Asia Club Tour, 6 April at KL Live
If our love's insanity, then Zedd is our Clarity (Hey, if you can catch the drift, you're truly a Zedd fan). Moreover, his collaboration with America's golden girl Hailee Steinfeld on Starving blew us away. And who can resist dancing to Get Low (with Liam Payne) and The Middle?
If you missed the tour, not to worry - check out the This Is: Zedd playlist for a collection of his most popular tracks.
● OneRepublic Live in Malaysia, 25 April at Merdeka Stadium
Did you know that frontman Ryan Tedder is a songwriting guru, having written songs for famous singers like Beyonce, Ellie Goulding and ballad superstar Adele?
While fan-favorite songs like Apologize and Stop and Stare catapulted OneRepublic to stardom, I Lived introduced fans to a similar yet monumental piece of music by the band. The song represented an empowering message as the band dedicated the song to the then 15-year-old Bryan Warnecke who live with cystic fibrosis.
In anticipation of their concert, have a listen to This Is: OneRepublic playlist.
● Helloween Reunites for Soundvalley Festival, 28 April at MAEPS Serdang (Indoor)
The metal band has been around for three decades! The band was formed in 1984 and one of its band member, Kai Hansen is (arguably) the man responsible for forming the band and earned his moniker as 'father of power metal'.
You can expect hit songs such as I Want Out, Forever and One and Ride the Sky at the concert later this month. For a full-blown playlist of Helloween's best songs, check out This Is: Helloween.
April is turning out to be a month filled with musical geniuses visiting our country. We hope you enjoy the diverse playlists and keep streaming on Spotify. Remember, without music, life would B-Flat!
#REEFISM #REEFISMTERRITORY #SPOTIFY
HIBURAN MUZIK


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In Photos: Treasure Island Music Festival 2013
Ted Maider
October 21, 2013 | 2:45pm ET
Winter is setting in over the Bay Area, as exhibited at this year's Treasure Island Music Festival. Now in its sixth year, the late autumn festival has since become the staple finale for the West Coast's outdoor offerings, but this year was quite a way to go out with a magnum set of headliners (Atoms for Peace, Beck) and a stockpile of solid opening acts (Animal Collective, James Blake, Japandroids). Unfortunately, with the temperatures dropping rapidly each day of the festival, less prepared fans left early and missed some of the weekend's top talent, proving once again that Californians don't like to think about winter.
Icy winds be damned, however, the sets wound up being both captivating and surreal; from Atoms for Peace's foggy Saturday experience to the chilled sweat Japandroids singer Brian King managed to work up. It was all worth surviving, even if it means we'll be dealing with pneumonia come Halloween. Grab a blanket and relive the weekend with a cup of hot Joe below.
Antwon
Robert DeLong
Sleigh Bells
STRFKR
Treasure Island Music Festival


.10 carat Genuine Diamond Super Techno Hip Hop Watch. Real Diamonds around the bezel totaling .10 Carats. The Case is IP Gold plated for a long lasting gold shine. The unique custom rubber band adds extra style and dimension to your diamond watch. Looks amazing when worn on your wrist. Order your Super Techno Diamond Hip Hop Watch today!


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Review: Blade of the Immortal (無限の住人)
Posted by ranpha on 4th April 2009
Posted in: anime review.	Tagged: Blade of the Immortal (無限の住人).	3 comments
Our main male protagonist is still kicking ass even when his brain is busted.
At first, I planned to watch an older but immensely popular anime series that was aired last century (title withheld to create the air of suspense), but the last subbed episode of Blade of the Immortal comes out and I know right away that I have to watch it. Then midway of watching that anime, Tytania (a series I heard people say is similar to Legend of Galactic Heroes) also finished being subbed. Therefore, I will watch these two anime first before I start watching this mysterious anime title after them. Blade of the Immortal is a 2008 anime; therefore it will compete with Wolf and Spice for Anime of the Year 2008 title.
Manji, a samurai that is immortal because of a certain encounter, is enlisted by a damsel-in-distress who wants to take revenge for the death of her parents. The not-so-dynamic duo then embarks into a journey to find the killers of her parents so that Manji can hack them to death.
The 13 episodes covers only maybe one-third of the manga storyline (which I read), in a slightly watered-down version. While the story itself is very good, its presentation is not exactly outstanding and surprisingly ordinary (the presentation in the manga version is better IMO). The presentation become worse as the series progressed, and the premature ending mercifully puts an end to this. Nevertheless, this anime has a good pacing, although I think it may have slowed slightly towards the end too.
Character developments are also done well, but I can help but think that this aspect could have become much better if the series has more episodes (The lack of episodes is probably the only weakness this anime has). It (character developments) revolves around the two main protagonists this time around, but I know the other characters will also have their own upgrades when the story develops further as it is in the manga. There are no strong characters in this anime though, because in essence Blade of the Immortal (manga or anime) is strongly story-driven instead of being powered by immense characters the way titles like Urusei Yatsura did.
The ending is decent and paved the way for a second season that I will definitely watch. Although I have not heard any news about a new season yet, unlike Nodame Cantabile series that will have a third season later this year.
Our hero also like to put women in their place in this chauvinistic Japan.
Character designs in this anime is excellent (a trademark of this series really), with diverse types of characters. Almost all the important characters are imported from the manga very well. This anime is more seinen-like like Nodame Cantabile is, although I have issues with the hair colors of some of the characters. Definitely a positive point for this anime.
Voice acting in this anime is also great, with Manji the main male protagonist being outstanding. Others have done a decent job too, although it will be hard for me to judge based on low airtime that some characters has. Also a positive point of this anime.
The OST in this anime is great, with some nice insert songs too. The OP theme is also decent but not so for the ED theme. Another positive point of this anime.
The animation in this anime is fluid even in fast-paced scenes. The choreography in this samurai series is excellent and more down-to-earth compared to similar series like Rurouni Kenshin or Samurai Deeper Kyo that put a lot of emphasis on overelaborate techniques. The director has done well except for the presentation issues I have mentioned in the story section.
8 out of 10. I am looking forward for a possible second season of this excellent series. Still, Wolf and Spice's reign as the holder of Anime of the Year 2008 title continues. Tytania is the next anime that will be reviewed in this blog later.
Some of the sick and sadistic things that happened in this anime.
← Review: Speed Grapher (スピードグラファー)
Review: Tytania (タイタニア) →
3 comments on "Review: Blade of the Immortal (無限の住人)"
nike total 90 on 22nd September 2011 at 5:17 pm said:
It seems you have done quite an research to write this post. Thanks for sharing the valuable information.
Watch Anime Online on 21st January 2010 at 5:48 pm said:
Thanks for the review
Watch Anime Online on 18th August 2009 at 2:30 am said:
Hey, this is really cool. Thanks!!


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Q: Unable to replace the content in String Builder I am having two string builders in which one holds the complete data and the other holds the data that should be replaced but I am unable to replace the content.
This is the code i have written
StringBuilder sb1 = new StringBuilder();
StringBuilder sb2 = new StringBuilder();

sb1.AppendLine("1111111111");
sb1.AppendLine("555555555");
sb1.AppendLine("666666660");
sb1.AppendLine("6666666601");
sb1.AppendLine("6666666602");
sb1.AppendLine("6666666603");
sb1.AppendLine("888888888");
sb1.AppendLine("99999999");
sb1.AppendLine("555555555");
sb1.AppendLine("666666661");
sb1.AppendLine("666666662");
sb1.AppendLine("666666663");
sb1.AppendLine("666666664");
sb1.AppendLine("888888888");
sb1.AppendLine("99999999");

sb2.AppendLine("6666666601");
sb2.AppendLine("666666661");

sb1 = sb1.Replace(sb2.ToString().TrimEnd(charRemove), "");
sb1 = sb1.Replace(sb2.ToString(), ""); // this also i tried

I would like to remove sb2 content

A: You mustn't use StringBuilder for sb2.
To make it short, you are telling .NET to replace 6666666601666666661 in sb1.
Try:
List<string> list2 = new List<string>();
list2.Append("6666666601")
list2.Append("666666661")

foreach (var str in list2)
{
    sb1.Replace(str + "\r\n", ""); // the \r\n are because you used `AppendLine`
}

(and I'm not even sure you want to use a StringBuilder for sb1. StringBuilder is used to "compose" strings, not to "collect" them)
Note that this is still wrong wrong wrong!
You would be much better to begin the sb1 with an empty line, like this:
sb1.AppendLine("");

so that you can Replace like this:
sb1.Replace("\r\n" + str + "\r\n", "\r\n"); // the \r\n are because you used `AppendLine`

in this way, 99 won't mach 1999, because 1999 will be \r\n1999\r\n while 99 will be \r\n99\r\n (we are adding a blank line at the beginning of the StringBuilder so that even the first element is preceeded by a \r\n. We are replaceing with \r\n because we are matching TWO \r\n, one before and one later, but one of the two must be preserved.)
I'll add that perhaps you simply exchanged StringBuilder for a collection of strings, and perhaps you wanted to do this:
List<string> str1 = new List<string>();
str1.Add("555555555");
str1.Add("666666660");
str1.Add("6666666601");
str1.Add("666666661");

List<string> str2 = new List<string>();
str2.Add("6666666601");
str2.Add("666666661");

str1.RemoveAll(p => str2.Contains(p));

A: The string held in sb1 does not contain the string "6666666601666666661", so there is nothing to replace.
If you are trying to replace all instances of the two strings "6666666601" and "666666661" that exist in the string held in sb1, you should replace each at a time.
string str1 = sb1.ToString();
str1 = str1.Replace("6666666601");
str1 = str1.Replace("666666661");

redpajama_set_name: RedPajamaStackExchange


I give time and money to my kids, because it makes me feel good inside especially when I see these students walking tall now when they have had mr labels since early in school."one of the greatest pleasures in life is doing something great when others says you can't and proving them wrong!
some folks question my teaching ability...I love to prove these jerks wrong!


Moving through your life alone. You start to get bitter at the milestones you've missed and the chances you'll never have. You see the graying of your hair and the years piling on like rust eating at the hull of a decommissioned ship and you realize that your opportunity for young love is already past. Even if you got it together and got in the game you'd just have a shot at middle aged love... A guy can be turned into a brave hero, caring gentleman and gallant chevalier, he can make you feel like a princess, thanks to skilfully expressed, sincere compliment. In order to give your special someone a good compliment you need to understand that men and women like different types of �praise�.
The kind of shyness that is implied when we're sitting close together and you want to say something that is bare and honest, but you can't quite bring yourself to look me in the eye when you say it. Maybe your gaze is dropping a bit, but your body doesn't shy away from me. If we're sitting really close, maybe your head seeks towards my shoulder or chest.
A guy can be turned into a brave hero, caring gentleman and gallant chevalier, he can make you feel like a princess, thanks to skilfully expressed, sincere compliment. In order to give your special someone a good compliment you need to understand that men and women like different types of �praise�.


As we embark on our XTime Expediton 2018, we will be hunting for treasures to bring back for our XTime Family. Once we return from our exploration, we will auction off these treasures so that proceeds will be donated to our XTime Family Club.
In a few more days, our view of the world will change. We will see places we've never dreamed of, and people and cultures that we've never imagined. So, gear up and mark your calendars, the countdown has begun.
This all started in May of 2016 in the Sin city Las Vegas. We were having Dinner at Emie Pawiks house and all of a sudden somebody said "Where and when is the next reunion?" I thought, well, next one should be an adventure instead of just eating and drinking. So, I shouted "How about Alaska Cruise in 2017 and European Cruise in 2018?!!!". Well, it looks like it stuck to everybody's mind. Then lots of our friends started to message me asking for it. Well then I asked, "Why not a big reunion where everybody will have fun and memories. Let's go for a European Tour and a Mediterranean cruise?". Then the rest is history. I do not know why I end up being the Tour organizer, planner, guide, accountant and everything!
Recommended Cruise Activities For The Young And The Restless.
Note that these activities must be approached with an open heart, open mind, and open eyes... but not necessarily with an open wallet. There's a lot of activities and entertainment that are free, and all you'll have to do is to show up. It is much more fun to go in groups, and have someone to share the laughter with so that someday when you grow old you will have someone to swap stories with.
1. The Piazza which has a daily entertainment before dinner time.
2. The Movies Under the Stars which comes with free pizza and popcorn.
3. For the dancerous kind who wants to dance the night away, there's a superb disco at the Skywalker's NightClub.
4. The Lotus Spa Fitness center is a good way to expend excess energy.
5. If exercising is not enough, there's always the pool and the sports courts.
Imagine playing on the green while surrounded by a beautiful blue ocean. Whether you're a dabbler or a devoted disciple of the game, our nine-hole miniature putting course will put your finer golfing skills to the test. After you play a round, step inside to try your hand at our golf simulator, which recreates some of the world's greatest golf courses like St. Andrews and Pebble Beach.
JUST FOR KIDS 8-12 YEARS OLD.
JUST FOR TEENS 13-17 YEARS OLD.
Recommended Cruise Activies For The Young At Heart and the Restful.
1. Princess Theater which has a daily evening show around 8 PM. it's a nice go to entertainment after dinner.
2. The Piano Bar which is open daily until midnight, is a nice go to entertainment right after the evening shows.
3. For those who love to do some light dancing, there are also some nightclubs with live music entertainment.
4. There is also some entertainment going on daily at The Piazza usually before dinner time.
5. The afternoon tea around 3 or 4 PM is not to be missed, it's a good way to meet new people.


Dining out in this city can sometimes require serious hoop-jumping. Parking. Concrete. Construction – oh, the construction. We've selected a few places where you'll find a slightly more, shall we say, holistic experience. Some of these gems require a drive (or a ferry) and some are right under your nose. Either way, you'll feel a lot less like you're lunching in a battle zone once you get there.
High above the glittering city sits this West Van specialty. Spectacular salmon, all-local ingredients and dishes paired with the best of B.C. wines accompany the finest views of any restaurant in the area. 2229 Folkestone Way, West Van., (604) 926-3212.
Sometimes we forget there's a world outside the downtown core, but there is. Floating atop the city in Queen Elizabeth Park, Seasons serves distinctive regional West Coast cuisine in a glass-encased room with a seriously green view. Try the weekend brunches, but be sure to make a reservation. Queen Elizabeth Park, West 33rd Ave. and Main Street, (604)-874-8008.
Sitting serenely on The Heights in North Burnaby, overlooking Deer Lake, The Pear Tree focuses on Continental cuisine made with the freshest local ingredients and has won Vancouver Magazine's Best of the Suburbs every year for the past decade. It's also been rated in Zagat's top ten. Try the olive-oil-poached sablefish. 4120 East Hastings St., Burnaby, (604) 299-2772.
For this one you'll need to catch a ferry. It's a rustic Bowen Island gem with an ivy-covered outdoor patio, perfect for an escape from the city. Authentic Tuscan cuisine with perhaps the best wood-fired pizza in all of Vancouver. 451 Bowen Trunk Road, Bowen Island, (604) 947-0550.


Adjustable-Rate Mortgage (ARM) – Loan with an interest rate adjusted according to movements in the financial market. Many offer lower-than-market initial interest rates that rise only gradually for the first few years.
Annual Percentage Rate (APR) – Annual cost of credit over the life of a loan including interest, service charges, points, loan fees, mortgage insurance and other items.
Appraisal – Unbiased, professional opinion of a property's value based on its style and appearance, construction quality, usefulness and the value of comparable properties.
Assessment – Tax levied on a property or a value placed on the worth of a property by a taxing authority.
Assumption – Transaction allowing a buyer to assume responsibility for an existing loan instead of getting a new loan.
Broker (Real Estate) – Person who receives a commission or fee for bringing buyer and seller together and assisting in the negotiation of contracts between them. A license is required in most states.
Building Code – Local regulations controlling design, construction and materials used in construction. Building Codes are based on safety and health standards.
Buy-down – Subsidy, usually paid by a builder or developer, to reduce the monthly payments on a mortgage loan.
Buyer's Agent – A real estate agent who represents only the buyer in a real estate transaction.
Callback – Request by a homeowner for a builder to handle a service request.
Cap – Limit to the amount an interest rate or monthly payment can increase for an adjustable-rate loan either during an adjustment period or over the life of the loan.
Certificate of Occupancy – Document from an official agency stating the property meets the requirements of local codes, ordinances and regulations.
Chain of Title – History of all documents transferring title to a parcel of real property, starting with the earliest existing document and ending with the most recent.
Change Order – Homebuyer's written authorization to add, delete or change an item specified in a contract.
Closing Costs – Charges paid at settlement for obtaining a mortgage loan and transferring a real estate title.
Commission – Agent's fee for negotiating a real estate or loan transaction, often expressed as the percentage of the sales price or mortgage amount.
Conditions, Covenants and Restrictions (CC and RS) – Standards that define how a property may be used and the protections the developer makes for the benefit of all owners in a subdivision.
Contingency – Condition that must be met before a contract is binding.
Convertibility – Ability to change a loan from an adjustable rate schedule to a fixed-rate schedule.
Deed – Legal document representing property ownership.
Default – When a borrower fails to make the required payments of a mortgage contract.
Density – The number of homes built on a particular acre of land. Allowable densities are determined by local jurisdictions.
Debt-To-Income Ratio – Long-term debt expenses as a percentage of monthly income; used by lenders to qualify borrowers for mortgage loans.
Due-on-Sale – Clause in a mortgage contract requiring the borrower to pay the entire outstanding balance upon sale or transfer of the property.
Earnest Money – Sum paid to the seller to show that a potential purchaser is serious about buying.
Easement – Right-of-way granted to a person or company authorizing access to the owner's land. For example, a utility company may be granted easement to install pipes or wires. An owner may voluntarily grant an easement or can be ordered to grant one by a local jurisdiction.
Equity – Difference between the value of a home and what is owed on it.
Escrow – Handling of funds or documents by a third party on behalf of the buyer and/or seller.
Escrow Amount – Amount set up by a lender into which periodic, usually monthly, payments for taxes, hazard insurance, assessments and mortgage insurance premiums are made. Funds are held in trust by the lender who pays the sums as they become due.
Fair Market Value – Price at which property is transferred between willing buyer and willing seller, each of whom has reasonable knowledge of all pertinent facts and neither being under compulsion to buy or sell.
Federal Housing Administration (FHA) – Federal agency that insures mortgages with lower down payment requirements than conventional loans.
Fixed-Rate Mortgage – Mortgage with an interest rate that remains constant over the life of the loan.
Hazard Insurance – Protection against damage caused by fire, wind storms or other common hazards. Many lenders require borrowers to carry it in an amount at least to the mortgage.
HVAC – Common building industry abbreviation for heating, ventilation and air conditioning systems.
Index – Interest rate or adjustment standard that determines the changes in monthly payments for an adjustable-rate loan.
Infrastructure – Public facilities and services needed to support residential development, including highways, bridges, schools and sewer and water systems.
Inspection – Examination of work completed on a structure to determine compliance with building code and other code requirements.
Joint Tenancy – Form of ownership in which the tenants own a property equally. If one dies, the other automatically inherits the entire property.
Loan Origination Fee – Lender will charge a fee for the cost of processing the loan, usually calculated as a percentage of the loan amount.
Loan-To-Value-Ratio – Relationship between the amount of a home loan and the total value of a property.
Lock-In Rate – Commitment from a lender to make a loan at a pre-set interest rate at some future date, usually for not more than 90 days. A fee may be charged to "lock-in" a rate.
Mortgage Commitment – Formal written communication by a lender agreeing to make a mortgage loan on a specific property, specifying the loan amount, length of time and conditions.
Mortgage Origination Fee – Charge for the work involved in preparing and servicing a mortgage application.
Permit – Document issued by a local government agency allowing construction work to be performed in conformance with local codes. Work may not commence until permits have been obtained, and each permit issuing agency must inspect the work at certain specified points during construction.
PITI – Principal, interest, taxes and insurance: the four major components of monthly housing payments.
Point – One-time charge assessed by the lender at closing to increase the interest yield on a mortgage loan.
Pre-settlement Walk-Through – Final inspection of house prior to closing, conducted by builder and buyer.
Principal – Amount borrowed, excluding interest and other charges.
Recording Fee – Charge for recording the transfer of a property, paid to a city, county or other appropriate branch of government.
Specifications – Contractual document describing in detail the work to be performed; method of construction; standards of workmanship; quality, type and manufacturer of materials and equipment for a particular project.
Tenancy in Common – Form of ownership in which the tenants own separate but equal parts. To inherit the property, a surviving tenant would either have to be mentioned in the will or, in the absence of a will, be eligible through state inheritance laws.
Title – Evidence, usually in the form of a certificate or deed, of a person's legal right to ownership of a property.
Veterans Administration (VA) – Federal agency that insures mortgage loans with very liberal down payment requirements for honorably discharged veterans and their surviving spouses.


Minimizing tau in adult mice reins in toxin-induced seizures, report scientists led by Timothy Miller, Washington University in St. Louis, Missouri, in collaboration with David Holtzman and John Cirrito. The results, outlined in the July 31 Journal of Neuroscience, suggest that reducing tau could benefit people with tau-related disorders marked by hyperactivity, such Alzheimer's disease (AD), wrote the authors. The study moves the field a critical step closer to tau therapy, commented Lars Ittner, University of New South Wales, Sydney, who was not involved in the study.
Mounting evidence suggests that tau plays a key role in neuronal hyperexcitability. For example, knocking out the protein protects mice against epilepsy-like activity (see ARF related news and ARF related news). Halving the amount of normal tau also protects hAPP mouse neurons against overexcitation brought on by Aβ (see ARF related news story), and tau seems to mediate Aβ's excitotoxicity at the synapse (see ARF related news story on Ittner et al., 2010). However, since these genetic models lack tau from birth, researchers wondered if compensatory mechanisms during development explained the protection from seizures. Would silencing tau in adult mice have the same effects?
To address this, first author Sarah DeVos and colleagues delivered anti-sense oligonucleotides (ASOs) developed by Isis Pharmaceuticals, Carlsbad, California, directly to the central nervous system (CNS) to knock down tau expression in adult wild-type mice. One month of treatment docked expression of endogenous tau mRNA and protein by more than 80 percent. The work was a collaboration with Isis.
The treated mice behaved as usual, with normal cognition and motor behavior. However, the oligonucleotides diminished seizures that were induced by intraperitoneal pentylenetetrazole (PTZ) or picrotoxin delivered directly to the hippocampus. These poisons evoke focal and global seizures, respectively. The strength of the seizures strongly correlated with levels of tau, such that less tau meant lower spike frequencies and weaker seizures. Mice with the least tau also took the longest time to reach maximum seizures induced by PTZ. Interestingly, the association between seizures and tau persisted in mice not treated with an ASO, suggesting that even just higher basal levels of the protein predispose neurons to hyperexcitability. This hints that levels of tau could predict susceptibility to seizures in people, suggested Miller.
"These important findings strongly support our view that reducing tau is a potentially viable therapeutic strategy, not only for AD but also for related tauopathies and other disorders associated with aberrant neuronal network activity," said Lennart Mucke, Gladstone Institute of Neurological Disease, San Francisco, California. Mucke said that although ASOs could be developed into a human therapy in principle, a small molecule approach would be easier to administer long-term to elderly people. Miller's group recently reported that an ASO against mutant superoxide dismutase 1, which causes a rare form of amyotrophic lateral sclerosis, appeared safe when delivered directly to the CNS through intrathecal infusion in a Phase 1 trial (see Miller et al., 2013). Mucke and others are searching for small molecule compounds that can suppress tau, and anti-tau immunotherapy is an active area of research (see ARF related series).
Ittner said more research should be done to examine tau's relationship to hyperexcitability in AD mouse models and other animal models of disease. Universal knockdown could be harder to achieve in larger brains, he pointed out, which means the strategy may not work well in humans. Miller next plans to look at PSAPP mice and strains that express human tau.
The implications of these results extend beyond therapies to the basic biology of tau, suggested David Sanders, also at WashU, who was not involved in this study. Sanders works in the lab of Marc Diamond, who studies propagation of tau among cells in the brain. Given that a tight correlation exists between tau levels and seizures on a short time scale, he doubts the association could be due to tau's known intraneuronal function of stabilizing microtubules. "The findings suggest to me that tau, possibly an extracellular form, plays a role in neuronal signaling," he said. "I suspect that in upcoming years additional functions will be attributed to tau that might explain this correlation between seizure severity and tau levels."
Scharfman HE. "Untangling" Alzheimer's disease and epilepsy. Epilepsy Curr. 2012 Sep;12(5):178-83. PubMed.
Götz J, Ittner A, Ittner LM. Tau-targeted treatment strategies in Alzheimer's disease. Br J Pharmacol. 2011 Nov 1; PubMed.


The purpose of this article is analyzing the impacts of climate change on red pepper yield in Korea, with employing a panel data regression model. Our results show that there is a negative impacts of high temperature and precipitation amount on red pepper yields. Especially high temperature and rainfall in July cause serious damage to red pepper yield. According to the reduction schedule on greenhouse gas emission(RCP 8.5 scenario.), red pepper yield would be 25.4% lower than it is, for reasons of high temperature and rainfall damages by the end of 21st century.
Cho, J. H., Cho, D. R., 1992, Determinant Factors for Demand and Supply for Apples, Pears, and Oranges, Korea Rural Economic Institute.
Desai, P., 1986, Weather and Grain Yields in the Soviet Union, International Food Policy Research Institute, Research Report 54.
Francisco, E. M., Guise, J. W. B., 1988, A Note on Establishing Yield-Rainfall Relationships, Elsevier Science Publishers B. V.
Intergovernmental Panel on Climate Change(IPCC), 2007, Fourth Assessment Report (AR4).
Kim, C. G., Jeong, H. K., 2010, Weather Impacts on Rice Production in Korea, Korean Journal of Agricultural Management and Policy, 37(4), 621-642.
Kwon, O. S., Kim, C. G., 2009, Climate Change and Rice Productivity: Nonparametric and Semiparametric Analysis, Korean Journal of Agricultural Economics, 49(4), 45-64.
Kwon, O. S., Lee, H. J., Roh, J. S., 2010, The Impacts of Agricultural R&D Expenditures on Food Self- Sufficiency, Korean Journal of Agricultural Economics, 51(2), 109-125.
National Institute of Meteorological Research, 2011, Future global climate change estimates calculated, Climate Research Division, Press Release(2011.6.27).
Pope, A. C., Earl, O. H., 1982, The Effects of Technological Progress and Weather on Corn Belt Crop Yields, CARD Report 113T.


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Kate Middleton Pregnant! This Time It's True, Palace Announces
Keith Girard December 3, 2012 BREAKING NEWS
Kate Middleton, whose pregnancy was announced almost every other week by gossip tabloids during her 18 month marriage to Prince William, really is pregnant this time, the Royal Palace has announced.
The Palace was forced to make the announcement a little sooner than expected because the Duchess of Cambridge was admitted to the hospital earlier in the week because of severe morning sickness. She is in the "early stages of her pregnancy," the palace said.
She is staying at the King Edward VII Hospital in Central London and will remain in the hospital under watch for at least the next several days, according to Buckingham Palace. Kate and William were married in April 2011. This is their first child together and comes about eight months later than Prince Diana's pregnancy with Prince William.
The child, even if it is a girl, will automatically become third in line for the throne behind William and his father Prince Charles, assuming Elizabeth II still reigns as Queen. Prince Harry will become fourth in line.
The couple said they are "delighted with the news," according to a statement on their website. "Their Royal Highnesses The Duke and Duchess of Cambridge are very pleased to announce that The Duchess of Cambridge is expecting a baby," the statement said.
Middleton's condition has a formal name; it's known as Hyperemesis Gravidarum, or acute morning sicknss. It can be dangerous because it causes pregnant women to lose weight, and Kate is notoriously thin.
Only last Friday, Middleton participated in field hockey game at her former school, St. Andrew's in Pangbourne, according to London's Daily Mail.
entertainmentgossip newsGreat Britain Royal FamilyKate MiddletonKate Middleton pregnantPalace pregnancy announcementprince william
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Positivism, Evolution Theory, Physiological Materialism, Spirituality Of The Mind, Evolution Theory Materialistic, And Therefore False, Validity Of À-Priori Notions, Origin Of À-Priori Notions, Refutation Of Sensualistic Ethics, Philosophy And The Supernatural, The Evolution Of Human Souls.Robert Lewis Dabney was perhaps the greatest of the 19th century Southern Presbyterian theologians. "He wrote ably on theology, politics, government, education, culture, and history." Yet he considered two of his books on philosophy to be in his own opinion his most worthwhile contributions.
In relation to the more famous Scottish names associated with Common Sense, Dabney followed Thomas Reid most closely. With his greatest energies Dabney plied his philosophical skills in reducing to absurdity the sensational philosophies of Berkeley, Condillac, Hobbes, Locke, James Mill, J.S. Mill, and Spencer. Evidence of his eclecticism and objectivity is seen in his many correctives offered to fellow Scottish Realist, Sir William Hamilton. Dabney's criticisms of his fellow Realists and refinements to the philosophical system he utilized so fully make him an interesting and profitable study for contemporary philosophers and apologists. This would be particularly true of those apologists who share Dabney's commitment to Reformed or Calvinistic theology. Dabney is proof that regardless of our nuanced differences in apologetics, we can learn much from the older theology and philosophy.
In the end, it may be that the greatest value in reprinting Dabney's "philosophic philippic" will be found in his evaluation of the evolution theory and its logical fallacies.
From the preface by C. N. Willborn.


Now me and my girlfriend G have arrived in Levanto a bit north of cinque terra. We live in the middle of the village of Levanto and just behind the "big" square which I think is called piazza Cavor if I've got it right. Still learning.
So we have gotten our apartment, made a quick visit to around the closest area and bough breakfast for tomorrow and some red wine and Apperol spritz. It's a real cosy little town.
We went out for dinner and had gnocchi and lobster and saffran. Good but not a favorite and some white wine from the area. After that we went to a bar and had a glass of red and some snacks where we spent most of the night just talking and looking at all the people passing by. It's a lot of Italians and not so many other tourists here which made me a bit surprised. So far so good.


On June 8, a Jacksonville, Florida, man stole cash from a Walmart register and then tried to steal a truck at knife point before the truck owner pointed a handgun at the man. The man fled to a nearby Starbucks parking lot, where he again attempted a carjacking—only to be confronted by another armed civilian. Police finally arrived to find the man barricaded inside a Supercuts bathroom, where he was eventually arrested.


Do you want your project to be completed on time and on budget? Of course you do. However, it's more complicated than you may think. Every project is unique and there are countless variables that come into play. When estimates are well thought out and dependencies are known, a realistic schedule and team can be put in place. Once the project starts, a project manager should have a methodology for tracking their project burn rate. In short, burn rate is the rate at which the project is spending its original budget. The team's performance for a given week or a delivery sprint will drive any adjustments the project manager needs to make to keep the project on track. These decisions will not only impact the success of the project, but they also drive business-level decisions, such as hiring, resourcing adjustments and employee mentoring. In this project insights article, we'll evaluate some of the common factors that are necessary to effectively track a project's burn and how these decisions can not only impact an individual project, but also business-level decisions.
With over 5 years of mobile app design and development experience, we leverage historical data to more accurately estimate the work that goes into each project. Not only do we analyze the time that past projects needed for design, development, and QA, but we also look at trends we are seeing in particular client projects. As a start to the process, each product feature is categorized and given a level of confidence. Whenever we have low confidence in an estimate for a feature, our first question is, "how can we increase our confidence?" This typically means that we need to review assumptions with our clients and dig deeper into the feature. The higher the confidence, the better chance we have for staying within budget and shipping on time. If we are unable to increase our confidence level, a load factor would be added to the estimate to pad the time needed.
We also use load factors for each category when estimating the work for a particular product release. As an example, a load factor percentage is applied to development estimates as developers need to also attend meetings and need time to fix bugs related to the feature work. Another example is that we use a percentage of development time to estimate the total QA time needed for a product release. There's an average we use based on the norm for past projects, but as we continue to release updates for our clients, we can track the historical data from previous releases to more accurately estimate future releases.
Are any team members taking vacation time and is it built into the schedule?
Was there padding added at the end of the schedule in case our estimates are off?
Did we analyze which features are most risky and prioritize them higher?
What's needed to drive the on-time delivery of any dependencies?
Will requirements be available before feature work is started?
Is QA involved early on to review requirements and build out test cases?
Whether a project is a fixed bid project or a time & materials project, a project manager still needs to evaluate their team's performance vs. criteria set from estimates. Since we typically plan work in 2-week sprints, a team's velocity can be tracked for each sprint, but also analyzed on a week to week basis. Let's use one simple example that can take us down various paths and impact the overall burn of a project.
One specific developer is estimated to complete 7 points of work in a two-week sprint (with 7 points equaling 7 ideal days or 56 hours). In this example, there is a load factor of 25%, meaning that there are still 3 days (24 hours) remaining for a 2-week (80 hour) sprint. This load factor accounts for meetings and bug fix time needed throughout the two-week sprint. Let's walk through some examples and the resulting decisions a project manager would make.
Scenario 1: A developer explains that they are struggling with a feature and will be 3 days (24 hours) late with it.
Result: The project manager needs to identify these issues as soon as possible in standup meetings to make sure the developer is getting the support they need. The project manager also needs to add 3 days (24 hours) to future projections as we are now 3 days (24 hours) over our original estimates.
Scenario 2: The developer is out sick for 5 days.
Result: The project manager adds 5 days (40 hours) to our forecast in later weeks as that time needs to be made up (which could also mean adding support from a new developer onto the project).
Scenario 3: The developer finishes 7 days of work in 4 days.
Result: The project manager can remove 3 days (24 hours) from future projections as we saved 3 days (24 hours) from our original estimates.
Scenario 4: There is a feature with really low confidence because the team is waiting for a SDK from a third party provider. Once the team gets the SDK and is able to analyze it, they find that it's going to take 2 weeks longer than the original estimate.
Result: The project manager would discuss the new findings with the client product owner and determine if lower priority scope would be cut from the release or if the schedule would be extended.
The list goes on and on, but you can see how the knowledge learned during a project's daily standup meeting and throughout a sprint will impact the adjustments a project manager will make to their project's projections. These projections impact the ability to ship on time and within budget. It's one thing if we end up over budget at the end of the project. It's way worse if we are over budget and it's a complete surprise at the end of a project. First, our clients will be upset. Secondly, our teams are often unhappy because the project manager didn't accurately predict the additional work needed, which results in a team working long hours before the end of the project. In this case, the project manager probably didn't provide support or add resources when needed. The project manager most likely also didn't communicate that the project was tracking behind schedule and didn't ask the client if the schedule could be adjusted. Lastly, these mistakes not only lead to team member burn out, but they also impact revenue projections for the business, which in turn can impact factors such as future hiring.
There are various tools that can be used to track a project burn, but at POSSIBLE Mobile, we found that it would be most effective to develop our own. Matt Mills, a Program Manager at POSSIBLE Mobile, created a homegrown burn report tool, which all project managers can use to track their project burn on a weekly basis. Schedules are built out after the completion of the estimation phase and then added into the burn report as a starting point for the project. The schedule outlines all estimated hours each team member will use throughout the given weeks for the project and it also takes into account variables such as planned vacation time. The burn report tool is used in conjunction with our time tracking software and it provides project managers a means to track the current project burn (hours and cost), projections (hours and cost we are trending to be under or over budget), and manage change request adjustments (hours and cost). Project managers can also document why adjustments are being made to projections and therefore adjust the forecast for upcoming hours in the schedule. The summary of these findings provides our company with a financial overview for every project and helps us understand our revenue projections. Summarized data is also pulled out of the reporting and added into a weekly report that is given to our clients along with overall status updates for each project.
Whether you have a homegrown tool or track a project's burn with specific software, project managers need to continually evaluate their projects to make the necessary adjustments. If analyzing the project burn isn't done accurately, everyone feels the pain.
Stay tuned for the next two project insights in the series. The fifth article in the series will cover steps to successfully shipping a mobile app or connected device. The last article in the series will cover the benefits of teams holding retrospectives, which help to determine what the team did well in the project versus areas that need improvement.


The Land Concern Newsletter! Keep up with the Latest Happenings.
We are excited to share some updates with you on what we have been working on here at Land Concern! Read on for more information and other exciting news.
ESENCIA'S THE HILLTOP WINS 2018 GOLD NUGGET AWARD!
The Hilltop Club at Esencia was honored with the Best Recreational Facility Use award, wowing the judges with its exceptional blend of space, inclusiveness and recreational amenities. Visit our NEWS article to learn about our team's involvement and our efforts on such an exciting project.
Framed by Rancho Mission Viejo hillsides, lush park spaces and a stunning landscape, Azure is the perfect place for families to experience natural beauty. Land Concern had the opportunity to transform these courtyards to whole other level, adding a sense of vibrancy that echoes the spirit of the local community. Visit our PORTFOLIO to learn more about this project.
Land Concern's thoughtful design principals add sophisticated touches of nature and calming energy to Cobalt. It's here in these paired homes where young families have an opportunity to experience the best of everything. To read more about how we incorporated organic elements into outdoor living areas and relaxing retreats, visit our PORTFOLIO.
Through thoughtful site selection and space planning, Land Concern had the opportunity to employ modern landscape design with an emphasis on luxury. Visit our PORTFOLIO to learn more how we made these personal oases' stand out.
ANDY BOWDEN'S HIGHEST HONOR FROM ASLA!
Each year the American Society of Landscape Architects nominates members who have made exceptional contributions to the Landscape Architecture profession and society at large. Bowden's grasp of issues and clear expression of ideas has granted him one of ASLA's highest honors. To read more about Andy's astonishing achievement, visit our NEWS article. Congratulations, Andy!
Stretching across 4.9 acres of breathtaking surrounds, the Inn at the Mission is strategically planned to respond to San Juan Capistrano's historic roots. To read more about the newest 4-star retreat coming to Orange County, visit our PORTFOLIO.
BOUTIQUE HOTEL DEVELOPMENT ON THE BOARDS!
Land Concern recently teamed up with the industry's finest on a milestone development. For more information on this exciting new mixed-use development, visit the PORTFOLIO.
A leading landscape architecture firm in Southern California, Land Concern's award-winning approach continues to redefine and evolve the playing field for its residential, commercial and hospitality clients.
If you're interested in receiving periodic updates on what we are up to, featured projects, industry news and highlights, leave us your email. We'll stay in touch.


Even with the best oral health regime, over time as we get older our teeth are prone to normal wear and tear. Paradoxically, as people's general dental health improves, more people retain their natural teeth later in life, meaning dentists are seeing and treating more cases of tooth wear.
There are three principle causes of tooth wear: erosion, attrition and abrasion.
Erosion occurs when the strong enamel coating covering the teeth is broken down by acid from acidic foods and drinks, as well as due to certain medical conditions. Once the enamel is gone, the body cannot repair it, leaving the teeth darker in colour, sensitive and more prone to decay.
Attrition is frictional wear and tear caused by chewing and grinding the teeth. This can be a problem for people who eat a lot of hard food and roughage (vegetarians are particularly prone to this) as well as those who suffer from bruxism (grinding of the teeth). Most of us will experience some form of attrition as we get older.
Abrasion is a form of wear and tear caused by poor tooth brushing technique, and in those who use their teeth to bite things other than food – pens, clips or pins, or in place of a bottle opener, for example.
In most cases, tooth wear can be treated fairly simply and quickly, although if left untreated more extensive restorative treatment may be required.


Hello EC readers and followers. Today, i want to bring to you an alternative way to browse with Etisalat socialme using a premium account with Tweakware. Though many users on this blog Entclass.com has been flexing with the latest MTN BB10 Maxi but am going to show you how i browse, stream and download unlimitedly without tweakware disconnecting using Etisalat socialme. The downside of it is that its not that fast but i consider it ok. Never to worry, i will update you guys on how to speed up your browsing and downloading speed, so stay glued.
With a premium account with tweakware vpn you will access all servers and never worry for disconnections like Netify vpn that disconnects frequently and you wont have any limit using Tweakware vpn premium account.
I will make this tutorial simple and understanding.
First of all, you have to pay some cash for the premium tweakware account @ N500 monthly. If you don't have an account with them, kindly create one before payment - Click here to create an account with them. After creating an account with them, kindly check their payment page on how to pay - Click here for it.
After that, go back to the home page and select a server. Choose either United states or Netherlands, then tap on Connect. It should connect within 5 to 10secs.
Now lets do a simple maths. You paid N500 for monthly tweakware premium account and subscribed Socialme monthly plan of N500 which makes N1,000. No data capped. i.e you will browse, stream and download unlimitedly for good one month without thinking of data with just N1,000, isn't that cool? I know many of us here spend x10 of it monthly. So, enjoy this.
The speed is kinda throtted, not that fast in downloading but its stable. Free to stream and its unlimited. No data capped. I promise to help you guys on how to bypass the throttling and make the download fast.
That's what i'm currently using now as at April 2nd 2016.
Please, don't just read and go away, kindly click on the share button below.
Must i root my phone to be able to use the VPN apps on my android phone?
You don't actually need to root your phone.
Bro pls I need 2 confirm is bbmaxi working well on Android phones?
Is there an alternative method using Psiphon?


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Artifact of the Month
July 2016: D.B. Cooper Plane Ticket
Directors, Then and Now
Famous Cases & Criminals
Field Office Histories
Seal & Motto
Stories & Multimedia
Artifact of the Month
The July 2016 Artifact of the Month is the plane ticket hijacker D.B. Cooper bought under the name Dan Cooper for the flight to Seattle. (Click image to view high-res.)
On November 24, 1971, a man calling himself Dan Cooper approached the counter of Northwest Orient Airlines in Portland, Oregon and used cash to buy a one-way ticket on a flight to Seattle, Washington. During the flight, Cooper handed the flight attendant a note indicating he had a bomb in his briefcase and wanted her to sit with him. The flight attendant stat down, and Cooper showed her a mass of wires and red-colored sticks. Cooper told her to take his demands to the pilot—he wanted four parachutes and $200,000 in 20-dollar bills.
Upon landing in Seattle, Cooper released the passengers in exchange for the money and parachutes but made several crew members remain, including the pilot. The plane took off again, and Cooper demanded a course be set for Mexico City. However, somewhere between Seattle and Reno, Nevada, a little after 8 p.m., Cooper jumped out the back of the plane with the parachute and ransom money, disappearing forever.
The FBI became involved during the flight and opened what has now become one of the FBI's longest cold cases in FBI history—NORJAK, for Northwest hijacking—a case that led us to interview hundreds of people, track leads across the country, and scour the plane for forensic evidence. July 2016's Artifact of the Month is the plane ticket Cooper bought under the name Dan Cooper for the flight to Seattle.
Many theories abound, and perhaps we will never know what actually happened to D.B. Cooper after he jumped. The Seattle Field Office has redirected resources allocated to the D.B. Cooper case in order to focus on other investigative priorities. However, the case remains an intriguing mystery for law enforcement and amateur sleuths, and though we will no longer actively investigate the case, should specific physical evidence emerge, individuals with those materials are asked to contact their local FBI field office.
Learn more about the D.B. Cooper hijacking case.
Complete list of Artifacts of the Month


Mt. Ararat and Mt. Satulick are peaks located on the west side of Mt. Rainier at the edge of Indian Henry's Hunting Ground. From the Kautz Creek trail head, follow the trail northward to approximately 5230', ascend a gully to the south ridge of Ararat, and scramble to the summit. Descend back to the Kautz Creek trail and continue northward to Indian Henry's Hunting Ground. Turn south on the Wonderland Trail and descend to Devil's Dream camp. Follow a bearing to 214 degrees southwest toward Satulick and follow easiest terrain to the summit. Descend Satulick to the Wonderland Trail and descend 6 miles back to the Longmire-Paradise Road. A car shuttle is necessary to return to the Kautz Creek trail head and pick up the car(s) left there.


For increased flexibility, you can now allow a user to disable the GlobalProtect app without providing a comment, passcode, or ticket number. Starting in PAN-OS 7.1, you can configure the Allow User to Disable GlobalProtect App option from a GlobalProtect portal agent configuration. In earlier releases, this option was only available in the Windows registry and Mac global property list (plist). Settings defined in the GlobalProtect portal agent configuration take precedence over settings defined in the Windows registry or the Mac plist.