It is important to attend regular routine dental check-up as any potential problems could be identified early and appropriate action can be taken. Tooth decay can, if left untreated, cause the total loss of a tooth within a year. For this reason it is important that you attend every 6 months.
Our Dentists will check your teeth for cavities and broken fillings or crowns. Dental decay may appear as a hole or sometimes as a dark shadow underneath the surface of the enamel. The dentist will then check the gums and your general oral hygiene to ensure there are no problems there. S/he may use a special probe to test the depth of the pockets around your teeth in order to detect gum disease early. Finally the soft tissues are checked for ulcerations or other lesions. The dentist may also check the jaws and associated muscles. The dentist may then take X-rays (radiographs) if necessary. These show any hidden decay between the teeth and the level of the bone which may indicate periodontal disease.
What is involved in your dental check-up?
> Head and neck - Your dentist will look for any problems on the exterior surface of your head and neck, as well as feel for any swelling or tenderness (which are signs of an infection or disease) in your lymph nodes and salivary glands in your neck area. We will also examine your temporomandibular joint to determine if it is working properly.
> Soft tissue - The soft tissues of your mouth include the tongue, inside of the lips and cheeks, and the floor and roof of the mouth. We will examine these areas for spots, lesions, cuts, swellings, or growths that could indicate an oral health problem. Your dentist will also inspect the back of your throat and tonsil area.
> Gum tissue - We will examine your gums and supporting structures of the teeth. Your dentist will look for signs of gum disease, which include red or puffy gum tissue and tissue that easily bleeds when gently poked. If your dentist determines you have gum disease, he or she might send you to a periodontist.
> Occlusion - We will check how well your upper and lower teeth come together. Your dentist might simply look at how your teeth meet, or he or she might take wax impressions of your teeth if a more careful exam of "your bite" is necessary.
> Clinical examination of teeth - We will check for signs of tooth decay by examining the surface of every tooth. He or she will likely poke your teeth with a dental instrument, called an explorer, to look for cavities. (Decayed enamel feels softer when poked compared to healthy enamel.) Your dentist will also check for any problems with fillings, braces, bridges, dentures, crowns, or other restorations.
> X-rays - We will take X-rays to look for signs of tooth decay, as well as for gum disease and other oral health problems.


This document lists the design goals and requirements that specifications would need to address in order to standardize various aspects of widgets. A Widget is an interactive single purpose application for displaying and/or updating local data or data on the Web, packaged in a way to allow a single download and installation on a user's machine or mobile device. Typical examples of widgets include clocks, CPU gauges, sticky notes, battery-life indicators, games, and widgets that make use of Web services, like weather forecasters, news readers, e-mail checkers, photo albums and currency converters.
This specifications is out of date. Please see the the latest Editor's Draft of this document in the W3C's CVS repository.
This document reflects three years of gathering and refining requirements for the Widget family of specifications. The requirements were gathered by extensive consultation with W3C members and the public, via the Working Group's mailing lists (WAF archive, WebApps archive). The Working Group's goal is to make sure that vendor's requirements for Widgets are complete and have been effectively captured. The Widget family of specifications has set out to address as many requirements as possible (particularly the ones marked with the keywords must and should).
A widget is an interactive single purpose application for displaying and/or updating local data or data on the Web, packaged in a way to allow a single download and installation on a user's machine or mobile device. A widget may run as a stand-alone application (meaning it can run outside of a Web browser), and it is envisioned that the kind of widgets being standardized by this effort will one day be embedded into Web documents. In this document, the runtime environment in which a widget is run is referred to as a widget user agent. Note that running widgets may be the specific purpose of a widget user agent, or it may be a mode of operation of a more generic user agent (e.g. a Web browser). A widget running on a widget user agent is referred to as an instantiated widget. Prior to instantiation, a widget exists as a widget package. For more information and definitions related to widgets, see the Widget Landscape document.
As argued by the Widget Landscape document, there is currently no formally standardized way to author, package, digitally sign or internationalize a widget package for distribution and deployment on the Web. In the widget space, although many successful widget user agents are now on the market, widgets built for one widget user agent are generally not able to run on any other widget user agent. This document, along with the Widget family of specifications, attempt to address the interoperability issues.
To be clear, this specification describes the requirements for installable/desktop or mobile widgets (akin to Apple's Dashboard, Opera Widgets, Opera Mobile Widgets. or Yahoo!'s Konfabulator Widgets). This document does not address the requirements of "web widgets", such as iGoogle Gadgets or Windows Live Gadgets, which are being specified by the Open Ajax Alliance's IDE Working Group. Please see the Widget Landscape document for a discussion on the differences between widgets and Web widgets.
Note: Only normative statements marked with the keywords MUST and SHOULD are required to be standardized by the Widget family of specifications. The Working Group will publish an informative Working Group Note at the end of the standardization process listing any requirements that were not formally addressed by the Widget family of specifications.
This section lists the design goals that the Working Group recommends a conforming specification adopt when attempting to standardize the various standardizable aspects of widgets identified in the Widget Landscape document. The requirements are directly motivated by the following design goals. The design goals are listed in alphabetical order.
A conforming specification needs to consider the development practices currently used by widget developers and promote relevant industry best-practice, such as MWBP and MWABP .
A conforming specification needs to deal with cases where an end-user acquires a widget package over HTTP or via some other non HTTP-based (offline) means, such as a local file system, Bluetooth or a Multimedia Message Service. In addition, a conforming specification needs to provide a means by which widgets can be updated when a new or different version of a widget becomes available. It must be possible to perform updates from online and offline sources.
This section enumerates the requirements that a conforming specification would need to address to standardize widgets. These requirements are directly motivated by the design goals and are based on an iterative process of feedback from the public, discussions with various vendors, and a survey of market-leading widget user agents Widget Landscape .
To provide a formal means for an author to denote that a widget package conforms to a W3C endorsed specification when a widget package is served over HTTP . In addition, the media type could potentially be used in conjunction with an auto-discovery mechanism, such as Atom Auto-Discovery , to facilitate deployment of a widget package.
A conforming specification MUST recommend a packaging format that supports both uncompressed data and OPTIONAL data compression. A conforming specification SHOULD also recommend at least one royalty-free default compression/decompression algorithm that is compatible with market-leading widget user agents and implementations of the packaging format on mobile devices.
To provide authors with a practical set of metadata elements that describe various aspects of the widget that may be used in various contexts. An example of reuse of metadata could include the ability to combine the widget metadata with GRDDL to produce RDF metadata descriptions about a widget.
Note: There are other WG's working on this requirement such as the Ubiquitous Web Applications Working Group (UWA-WG), and the Open Mobile Alliance (OMA) Device Capabilities Working Group, and Open Mobile Terminal Platform's BONDI initiative.
A conforming specification SHOULD specify a means that allows authors to open IRI s in an appropriate scheme handler (e.g, using the default Web Browser to open HTTP URIs).
Multipurpose Internet Mail Extensions (MIME) Part Two: media types, N. Freed and N. Borenstein, November 1996. Available at http://www.ietf.org/rfc/rfc2046.txt.
FIPS PUB 186-2. Digital Signature Standard (DSS). U.S. Department of Commerce/National Institute of Standards and Technology.
The Unicode Standard, The Unicode Consortium, Version 5.


Home > Books > Stone the Crows is COMING SOON!
Stone the Crows is COMING SOON!
I am delighted to announce that Stone the Crows by TA Moore, the second book in the Wolf Winter series, will be published by Dreamspinner Press in May. I'll let you guys know when pre-orders are available, but for now I'm just chuffed it won't be long now!


Residents are enchanted by tall lush trees and stunning original Victorian architecture. Originally farmland, Cedar Park was built between 1850 and 1910 as a Center City suburb connected by horsecars and trolleys.
West of University City, Cedar Park is located between Larchwood & Kingsessing Avenues and 46th Street to 52nd Street. Gentrification began in the early 2000s do to U-City redevelopment, and you can imagine that a large student population has migrated into the area. However, many original and culturally diverse residents still hold the land and these gorgeous sizable homes with festive porches.
Although primarily residential, the area's vibrant, artistic, and cultural influences have fostered an array of gatherings, events, and businesses. Dock Street Brewey and Restaurant is a notable place to visit, transformed from an old firehouse.
If you're looking for homes with character, look no further. Inside and out, you will find true gems featuring inlay hardwood floors, stained glass, formal seating areas, and yards with plenty of greenery. The area is known for its creatively decorated front porches, and it's a real treat viewing the various home personalities as you stroll down the block.


Isn't pride a sin? I think so. Anyway, I take great pride in keeping my 12 year old Honda Accord in working condition. I'm gonna drive that POS until the wheels fall off. Except for a ton of dings and a few quarks, it's actually in good shape. As long as it gets me where I'm going, I'm happy.
A few days ago, my headlight burned out. Ugh. I replaced them once before (I told you, I've had this car for a long, long time) so I figured, "no problem". I went to Advanced Auto, got the right bulb, and scooted home...again proud of myself for only spending $8.
I get home, pop open the hood, move the radiator overflow tank out of the way and get to work. First off, the cap/gasket-like ring is jammed. After a half hour, I get out the serious tools: screwdriver and hammer. That's right...it's wrecking time! Even after bloodying myself, the gasket won't budge. Ok, time to call in the big guns: Lockjaw Pliers! I locked on to the old socket and just started yanking. Yeehaww!
bulb out. Seemingly, nothing is irreparably broken. I bust out the shiny replacement bulb...ugh...not fitting. (I even consulted my owners manual...the shame.) After triple checking the part number and trying every way from Sunday to get this guy in, I give up. 1.5 hours expended--still a pidittle.
At the end of my rope, the following day, I plead mercy with Advanced Auto, "...anything you can think of?" There's a pause on the other end, "Well, sir, I hate to insult your intelligence but perhaps are you attempting to replace the high beam instead of the low beam?" Crap. I'm an idiot. I sheepishly thank him for the advice--knowing for sure that's the issue.
On the way home, I buy a second low beam (don't want to do this again for a while) and a high beam bulb to replace the one I mistakenly murdered with the Lockjaws. Sure enough, the high beam bulb drops right into the hole. All told, it takes me 5 minutes (tops) to replace three bulbs.
Moral of the story: always make sure you're working with the right beam when replacing headlights!
Props to Advanced Auto...thanks for helping me through my bonehead move. BTW, I really like this store--only auto store I'll visit. They came out to the parking lot to test and replace my wife's car battery for her--no extra charge. Nice.


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Big Picture, January 2018
Portland Fossil Fuel Ordinance Ruled Constitutional
by Oregon PeaceWorks • January 7, 2018 • 0 Comments
January 4, 2017 (Salem, OR) — Today, the Oregon Court of Appeals reversed, in large part, a Land Use Board of Appeals (LUBA) decision that invalidated Portland's landmark Fossil Fuel Terminal Zoning Amendments, passed unanimously in December 2016. The Court ruled that Portland did not violate the Dormant Commerce Clause of the U.S. Constitution. The Court's decision opens the door for local governments to continue to take meaningful action to combat climate change.
Last August, the Portland City Council unanimously voted to appeal LUBA's decision, which stuck down the city's ordinance. A coalition of organizations represented by the Crag Law Center, including Oregon Physicians for Social Responsibility, Center for Sustainable Economy, Columbia Riverkeeper, and Audubon Society of Portland, intervened to support the city's defense of the fossil fuel ordinance.
The Court of Appeals also reversed LUBA's ruling that the ordinance violated Statewide Planning Goal 12, which governs transportation planning. The Court concluded that the ordinance does not impact transportation facilities or the flow of goods and services in the local and regional economy. The Court sustained LUBA's ruling that Portland violated Goal 2 of Oregon's statewide planning goals. The City of Portland can cure this defect through additional procedure and reinstate the Fossil Fuel Terminal Zoning Amendments.
"We're thrilled. Today's decision affirms that Portland and other communities can implement innovative protections to counter threats to human health and safety from dangerous fossil fuel infrastructure, " stated Regna Merritt of Oregon Physicians for Social Responsibility.
"As we feel the effects of climate change, from forest fires to ice storms, the City of Portland and its grassroots climate activists are leading the way on solutions," said Mia Reback lead organizer for 350PDX. "Today's decision allows Portland to continue its internationally recognized work to stop fossil fuels, reduce greenhouse gases, and ensure a justice based transition to 100% renewable energy."
"The Court's decision confirms the City's ability to stand up for the health, safety, and environment of its residents by restricting dangerous developments such as new oil train terminals," said Dan Serres, Conservation Director of Columbia Riverkeeper.
"Today's decision to uphold the landmark policy to restrict Fossil Fuel development is a huge win for the City, its residents and anyone concerned about ensuring that local jurisdictions are able to maintain the ability to protect their communities and fight climate change," said Bob Sallinger, Conservation Director for Portland Audubon. "It is disappointing that the Portland Business Alliance would join Big Oil in trying to reverse critically important efforts to protect our local environment."
"This is an important signal to other local governments that they can protect their residents from the many dangers of the fossil fuel industry," said Nicholas Caleb, the Staff Attorney at the Center for Sustainable Economy. "Many other municipal governments were waiting on this decision to follow Portland's lead and continue to fight together for a healthy climate system and truly sustainable economy."
"We are encouraged by the Court's rejection of the fossil fuel industry's effort to defeat local action to protect our climate and communities from the dangers of fossil fuels," said Maura Fahey, Staff Attorney at Crag Law Center. "Right now, it is up to local communities to stand up for our future and to push back against the fossil fuel industry."
Read the opinion here – http://www.publications.ojd.state.or.us/docs/A165618.pdf
Oregon Physicians for Social Responsibility, Portland Audubon Society, Columbia Riverkeeper, and Center for Sustainable Economy are represented in this case by Crag Law Center, a nonprofit public interest environmental law organization.
Bob Sallinger, Audubon Society of Portland, 503.380.9728, bsallinger@audubonportland.org
Nicholas Caleb, Center for Sustainable Economy, 541.891.6761, nick.caleb@sustainable-economy.org
Mia Reback, 350PDX, 310.717.7966, mia@350pdx.org
Dan Serres, Columbia Riverkeeper, 503.890.2441, dan@columbiariverkeeper.org
Regna Merritt, Oregon Physicians for Social Responsibility, 971.235.7643, regna@oregonpsr.org
Maura Fahey, Crag Law Center, 503.525.2722, maura@crag.org
Tags: Center for Sustainable Economy Columbia Riverkeeper Crag Law Center Land Use Board of Appeals (LUBA) Oregon Court of Appeals Oregon Physicians for Social Responsibility Portland Audubon Society
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Sue Day
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England National Rugby Union
Sue Day became RFU Chief Financial Officer and a member of the RFU Board in April 2018. In October 2019, that role changed to Chief Operating and Financial Officer.
Sue is responsible for finance, legal and governance, technology, people, strategy and Twickenham Stadium, reporting to CEO Bill Sweeney.
She is a qualified chartered accounted with over 20 years' experience in a variety of roles at KPMG, most recently as Deal Advisory Partner. Having been appointed partner in 2015, she worked as lead partner on a number of high profile mergers, acquisitions and corporate finance transactions before joining the RFU.
A former England rugby captain and prolific try scorer, Sue was also President of Wasps FC from 2013-18 following a distinguished 14-year playing career with the club. She was capped 59 times for England, winning three Grand Slams, and also captained the England Sevens team and coached the developmental team.
She is a founding trustee of the Women's Sports Trust, and has been a rugby commentator for Sky Sports and World Rugby. Sue was awarded an MBE in 2020 for services to gender equality in sport.


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Home News Briefs Bonnefield Financial gets top marks for responsible investing
Bonnefield Financial gets top marks for responsible investing
Bonnefield Financial, a private equity firm that specializes in investing in Canadian farmland, has earned an "A" rating from the United Nations-supported Principles for Responsible Investment (UN-PRI). UN-PRI is a global network of investors that work together to put six principles for responsible investment into practice. Toronto-based Bonnefield became a signatory in December 2014. Early last year, the firm closed its third fund, Bonnefield Canadian Farmland LP III, at $261 million.
Bonnefield Financial Earns High Marks for Responsible Investing
TORONTO, ONTARIO — (Marketwired) — 10/01/15 — Bonnefield Financial is pleased to announce it has earned an "A" rating from the United Nations-supported Principles for Responsible Investment (UN-PRI) for its overarching approach to responsible investment.
In December 2014, Bonnefield became the first farmland investment management company in Canada to become a signatory to UN-PRI, a network of global investors committed to working together to put principles of responsible investing into practice. Signatories follow a set of six principles that protect the environment, benefit society, and promote sound governance through integrity and transparent reporting.
As part of their commitment, signatories agree to an annual assessment of these principles. Bonnefield earned a mark of A for the overarching approach module, scoring exceptionally high for its responsible investing policies (including policies for managing conflicts of interest), roles and responsibilities, performance management and rewards, independent promotion of responsible investing and dialogue with public policy makers. (Across 924 companies, the median score was B.)
Bonnefield's goal is to protect the integrity of "farmland for farming" by working with local Canadian farm operators to help them grow, reduce debt and diversify their assets, while promoting sound farming practices. Bonnefield's approach to social responsibility and its assessment can be found on its website.
About UNPRI
The United Nations-supported Principles for Responsible Investment (PRI) Initiative is an international network of investors working together to put the six principles for responsible investment into practice. Its goal is to understand the implications of Environmental, Social and Governance issues (ESG) for investors and support signatories to incorporate these issues into their investment decision making and ownership practices. In implementing the principles, signatories contribute to the development of a more sustainable global financial system. Visit www.unpri.org.
About Bonnefield
Bonnefield is Canada's only national farmland investment management and property management company with more than $328 million under management. To date Bonnefield's partnerships have secured approximately 48,000 acres of farmland for farmers located in British Columbia, Alberta, Saskatchewan, Manitoba, Ontario, New Brunswick and Nova Scotia.
Bonnefield's goal is to protect the integrity of "farmland for farming" while increasing its long-term value for investors.
Bonnefield Financial is headquartered in Toronto, Canada with offices in Ottawa.
Bonnefield Financial
Lisa Courtney Lloyd
lclloyd@bonnefield.com
www.bonnefield.com
@Bonnefield
Firms and Funds
Main Street Capital recaps Nebraska Veterinary Services and Heritage Animal Health
Longford Capital amasses over $434m for third fund


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Automotive Production Development Programme: Phase 2 Now Gazetted
We're thrilled to let you know that the long-awaited Automotive Production Development Programme Phase 2 (APDP2) regulations were published in the Government Gazette dated 11 February 2021. The APDP2 regulations were originally expected to have come into effect on 1 January 2021, however, they were delayed for implementation effective from 1 July 2021. Minister Patel signed the APDP2 Regulations on 4 February 2021 allowing for the regulations to be published in last week's gazette.
The published regulations did not include any of the information documents that accompany the regulations. These are expected to be released shortly. The operational detail lies in these documents. We will update you on developments in this regard as soon as the information becomes available.
B-BBEE compliance requirements remain unchanged from the draft regulations. However, the gazetted regulations do not provide clarification in respect of the exact B-BBEE compliance levels, despite assertions in the press of Level 6 for 2022 and Level 4 for 2023. We expect the Minister will clarify these details in due course, particularly with regards to the time-frames for implementation of minimum compliance levels.
The major changes and differences from the draft APDP2 Regulations published for comment in July 2020 are:
Motorcycles have been removed from the regulations in their entirety and all reference to rebate item 317.01 has been removed.
Definitions which have been included that did not appear in the draft guidelines:
"Environmental levy": defined as the levy on tyres manufactured in South Africa under rebate item 152.00 in Section E of Part 3 of Schedule 1 to the Customs Act.
"Non-standard material(s)": defined as any imported component, and/or raw material or component other than the defined standard material used in the manufacture of any qualifying or eligible product.
"Semi-knock down": defined as a vehicle manufactured to an untrimmed painted body condition with no parts assembled to the body.
The definition of standard materials has been expanded to include a specification stipulated in Info Doc A, Note 4.4. The information documents have not been released and further detail on the contents of Note 4.4 cannot thus be provided as yet.
In Part B – General Provisions: Clause 3, "Applicability of the Regulations" has been added. This clarifies that any discrepancy or inconsistency between the regulations and the info documents, the regulations shall trump the info documents. This provides clarity with regards to the treatment of conflicts.
Eligible Products has been expanded to include manufacture of vehicle kits for assembly outside South Africa to qualify for the Production Incentive benefit. This is a totally new addition to the programme.
The sunset date for the Annual PI Factor for Component Manufacturers has been removed, which sees the alignment with the Annual PI Factor time-frame for assemblers.
The reduction by 20% of component PRC values has been removed. This is a deviation from the APDP Phase 1, where component PRCC values were reduced by 20%.
In the Transitional Notes, the Company Specific Percentage for VALA for Quarter 3 2021 will be determined and based upon Quarter 4 2020. Quarters 1 and 2 of 2020 are not included in the baseline calculation.
Should you have any queries or require assistance with the published APDP2 regulations, please contact Cova Advisory & Associates on 011 568 3350 or email us using the details below.
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All lymphoid cells are considered to be products of hematopoietic stem
Brandy HoltFebruary 13, 2017Phosphoinositide-Specific Phospholipase CGSK429286A, Rabbit Polyclonal to DCLK3.
All lymphoid cells are considered to be products of hematopoietic stem cells (HSCs); GSK429286A however it has been suggested but not proven that innate immune B-1 progenitor cells develop independently of HSCs in the fetal liver. in the development of this lineage. The immune layered model proposed GSK429286A by Herzenberg and Herzenberg in 1989 (1) predicted B-1 and B-2 lineage production through three waves of B lymphopoiesis arising from different precursors during development (2): According to this model the first wave gives rise exclusively to innate immune B cells in early embryonic life and may be derived from progenitor cells independent of hematopoietic stem cells (HSCs) challenging the stem-cell theory that all blood cells are products of HSCs. The second and third waves are comprised of HSCs and HSC-derived progenitors in the fetal liver neonatal bone marrow (BM) (the second wave) and adult BM (the third wave) respectively. Importantly AA4.1+CD19+B220lo-neg B-1 specific progenitors have been identified in the second wave (3). The second wave produces more B-1 cells than B-2 cells whereas the third wave displays an opposite skewing of B-cell differentiation (4-7). In fact the B-1 cell-producing abilities of HSCs and common lymphoid progenitor cells decline with advancing age (6) and in particular CD5+B-1a cells are not produced by adult HSCs when examined by single HSC transplantation assay (7). Although the second and third waves have been examined in detail it is unclear whether the first wave exists and contributes to innate immunity in postnatal life and whether the B-1 progenitor cells in wave 2 in the fetal liver are all HSC-derived or contain derivatives of the wave 1 HSC-independent embryonic progenitor cells. Murine B-1 cells are innate immune cells (distinguished from conventional B-2 cells by specific surface markers such as IgMhiIgDloCD11b+) residing in the peritoneal and pleural cavities. These cells produce stereotypic natural antibodies in a T cell-independent manner and execute important roles in the first line of defense against microbial infection (8 9 B-1 cells are segregated into CD5+B-1a and CD5?B-1b cells. Marginal zone (MZ) B cells named after the restricted localization of these cells in the splenic marginal zone are usually categorized as BM HSC-derived B-2 cells but share similar functions with B-1 cells such as rapid production of IgM antibodies against bacterial pathogens in a T cell-independent manner. There is evidence that a portion of MZ B cells is also of embryonic or fetal origin (10-12). We have recently reported that yolk sac (YS) GSK429286A and para-aortic-splanchnopleura (P-Sp) hemogenic endothelial cells (HECs) harvested before the first emergence of HSC give rise to transplantable functional B-1a B-1b and MZ B cells in vitro and thus have provided supportive evidence for the first wave of B cells (13). However because we isolated and cultured YS/P-Sp cells in vitro to allow them to differentiate into B-1 progenitor cells whether YS/P-Sp-derived B progenitor cells seed the fetal liver in vivo and contribute to the B-1 progenitor cell pool or mature B-1 or MZ B cells in postnatal life has never been established. In other words to address the question whether the first wave of B lymphopoiesis is present in vivo or not we have to confirm the existence of HSC-independent B-1 progenitor cells in the fetal liver. The fetal liver is an organ dependent upon hematopoietic stem/progenitor cell seeding from different hematopoietic tissues. It is an established concept that erythro-myeloid progenitors (EMPs) derived from embryonic day (E) 8.5-E10 YSs Rabbit Polyclonal to DCLK3. seed the fetal liver to support homeostatic hematopoiesis in the GSK429286A embryo whereas HSCs that emerge in the aorta-gonado-mesonephros (AGM) region seed the fetal liver at E11 and provide hematopoietic support later in development (14 15 However it is unknown whether the YS/P-Sp HEC-derived B-1 lymphoid progenitors seed the fetal liver. Because the B-1 progenitor cell pool in the fetal liver is considered to be an HSC derivative and because HSCs exist in the fetal liver concomitant with B-1 progenitor cells it has been impossible to prove the existence of HSC-independent B lymphopoiesis in the fetal liver. To specifically address this question we have used a unique mouse model devoid of HSC but known to possess.


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Sign up for Medicare Part B no later than eight months after you leave your job or you could be hit with lifetime penalties.
QI signed up for Medicare Part A when I turned 65, but I didn't enroll in Part B because I was still working and had health insurance from my employer. But now I'm 68, and I plan to retire later this year. What do I need to do to enroll in Medicare Part B, and when do I need to do it?
Many people who are still working just sign up for Medicare Part A at 65 (because it's free) and delay signing up for Part B while they're covered by their employer's insurance. But you must sign up for Medicare Part B no later than eight months after you leave your job and lose that coverage, or else you could get hit with a lifetime penalty and a gap in coverage.
You can't sign up online because your employer needs to provide proof that until now you had coverage at work. You can submit the paperwork by mail or in person at your local Social Security office. You will need to fill out the following forms: CMS-40B Application for Enrollment in Medicare Part B and, because you worked past 65, CMS-L564 Request for Employment Information, to be filled out by your employer. If you've had more than one job with health coverage since you turned 65, you'll need each employer to fill out a separate form.
It will probably take the Social Security Administration a while to process the paperwork. Tatiana Fassieux, California Health Advocates board chair, recommends mailing your application or making an appointment with Social Security at least two months before you retire to ensure that your Part B coverage begins the first month you're officially retired. The Social Security office can also give you a letter of eligibility or enrollment so you can start looking for a medigap policy, and for a Medicare Part D prescription plan or a Medicare Advantage plan, she says.
Keep in mind that only health insurance from a current employer counts as eligible coverage for delaying Medicare sign-up. If you have retiree health coverage or if you continue your employer's coverage through COBRA, you'll still need to sign up for Medicare Part B within eight months of leaving your job, says Medicare advocate Sue Greeno, of the Center for Medicare Advocacy.
You can get help with the process from your local State Health Insurance Assistance Program (see the SHIP resource page for links to your state contacts). Also see the Center for Medicare Advocacy's Eligibility & Enrollment information and the Medicare Rights Center's Special Enrollment Period fact sheet.