text:
The home of the Lonsdale Battalion 1914-1918
For events that took place elsewhere in the Great War, see The Great War:23 December.
Lonsdale Battalion events that took place on 23 December.
1914[edit]
Lt-Col. Machell to Lord Lonsdale: "Your magnificent present of cigars has arrived and they have been distributed. Being in boxes of 25 this was easy, and there is great excitement about it. Thank you once more for all the kind things you have done. Our Xmas card has turned out rather a poor affair. The wretch said he could not use the good photo you sent because it was not toned & substituted this bad one! ... Grand weather for work now. I hope by next Xmas the Battalion will have made a good name, & that you will never regret all that you have done for us – we will do our best." [1]
Arrangements are made for C Company to travel from Kendal to Carlisle.
"Lady Valda Machell has collected from kind friends over 1200 pairs of wool mittens which have been made as Xmas presents to the Lonsdale Battalion. These mittens have been issued to Companies today – should be distributed to Officers, N.C. Officers & men forthwith." [2]
Battalion is relieved by the 17th Highland Light Infantry and proceeds to Bouzincourt.[3]
"First week in trenches, only six casualties, one, Nicholson (of Carlisle), since died. The 51st Division, to which we were attached, especially thanked Rycroft for the way the 11th Borders had played up." [4] – Lt-Col. P.W. Machell [5]
Battalion situated at Puchevillers involved in training under Company arrangements.[6]
Battalion situated in the front line; all quiet, however, 2nd Lieut. W. McKinlay is wounded.[7]
2nd Manchester Regiment relieve the Lonsdales; relief completes at 11pm. Battalion proceeds to Winnipeg and entrains for Trois Tours, then marches to 'Siege Camp,' all present in camp by 5am on 24 December.[7]
References / notes[edit]
Material from Timeline/Chronology of the Lonsdale Battalion (September 1914 - May 1915) are sourced from the DLONS/L/13/13 Lowther Estate Archives. Entries from this timeline are reproduced here with kind permission of Jim Lowther and are not available under the license of this site. Please do not publish these extracts on other publicly visible media without prior permission from the copyright holder.
↑ Record No. DLONS/L/13/13/279
↑ Record No. DLONS/L/13/13/?
↑ 11th Battalion War Diary, November to December 1915
↑ Not meant in the sense to misbehave or aggrandise, but rather more appropriately and positively how they engaged themselves in their actions.
↑ Record of the XIth (Service) Battalion (Lonsdale) - In France
↑ 11th Battalion War Diary, December 1916
↑ 7.0 7.1 11th Battalion War Diary, December 1917
Retrieved from "https://thelonsdalebattalion.co.uk/w/index.php?title=23_December&oldid=40673"
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Biography 2018-2019 | Emerson String Quartet | Kirshbaum Associates Inc.
Other North American highlights include subsequent performances of Shostakovich and The Black Monk: A Russian Fantasy, the new theatrical production co-created by the acclaimed theater director James Glossman and the Quartet's violinist, Philip Setzer. The music/theater hybrid, co-commissioned by the Great Lakes Chamber Music Festival, Princeton University and Tanglewood Music Festival, has been presented at the Ravinia Music Festival, Wolf Trap, and in Seoul, South Korea. In spring 2019, the quartet will reprise this work at Stony Brook University and the Orange County Performing Arts Center. In a bold intersection of chamber music and theater starring David Strathairn/Len Cariou andJay O. Sanders/Sean Astin with the Emerson String Quartet,the audiences witness the trials of Dmitri Shostakovich's 40-year obsessive quest to create an opera based on Anton Chekhov's mystical tale: The Black Monk.


This great 'Morning Kickstarter' Smoothie can be incorporated into anyones lifestyle whether you are vegetarian or not. The reason the title includes 'vegetarian,' is for someone who has recently made the change. Becoming vegetarian, you can find yourself baffled on what to eat and you may not enjoy the idea of actually having to eat loads of raw fruit and vegetables.
So this smoothie is a great way to give you a whole hoist of natural vitamins and minerals without having to physically eat so many pieces of fruit! It tastes great and provides a great energising and recovering boost!
It is also a great way to get yourself to drink quite a bit of water, which is always good!
The smoothie's ingredients consist of various fruits and vegetables and Future Life's High Protein Smart Food which gives it a bit more flavour if you like that. Have the drink first thing in the morning or straight after a workout and feel free to add or replace any ingredients as you see fit. You can adjust the liquids to your preference.
*The smoothie can be made vegan also by replacing the future life powder with something like Hemp protein powder.
Measure out and put all the ingredients in a blender and Blend away!
Its that easy and simple, now enjoy the nutritious smoothie full of natural vitamins and minerals which will boost your energy levels!


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Home / Employees / Patrick Wellein, M.C.E., P.E., HCI-R/C
Patrick Wellein, M.C.E., P.E., HCI-R/CCivil Engineer
C.E. Civil Engineering, Structural Focus, Johns Hopkins University
S. Civil Engineering, Structural Focus, University of Maryland, College Park
S. Engineering Transfer, Anne Arundel Community College
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CertainTeed Master Shingle Applicator
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Evidence Technician, Trident Engineering Associates, Inc., Annapolis, Maryland
Commercial / Residential Roofing Foreman, W & K Contractors Inc., Linthicum, MD
Commercial / Residential Roofing Laborer, W & K Contractors Inc., Linthicum, MD
AWARDS AND HONORS:
Dean's List, University of Maryland, College Park, (2012, 2013, 2014)
Invitation for Valedictorian, Anne Arundel Community College (2012)
Dean's List, Anne Arundel Community College (2010, 2011, 2012)
3 Year High School Graduation, North County High School (2009)
Honor Roll, North County High School (2007, 2008, 2009, 2010)
American Society of Civil Engineers (ASCE)
Structural Engineering Institute (SEI)
Trident Engineering Associates, Inc.
2010 Industrial Drive
Carlisle Branch Office
1000 Newville Road
©2019 Trident Engineering. All Rights Reserved.
Michael Smith, CFI, CFEI, CVFI
M. Aaron Carr, M.S.M.E.

redpajama_set_name: RedPajamaCommonCrawl


text:
[//]: # (title: ReSharper Platform Plugin Template)

<!-- Copyright 2000-2022 JetBrains s.r.o. and other contributors. Use of this source code is governed by the Apache 2.0 license that can be found in the LICENSE file. -->

Creating new ReSharper and Rider plugin projects is performed using the dedicated `dotnet new` template.
The generator creates all the necessary project files based on a few template inputs.

<procedure title="Create ReSharper & Rider Plugins" id="create-ide-plugin">

Launch the <control>New Project</control> wizard via the <menupath>File | New | Project...</menupath> action and provide the following information:
1. Download the [plugin template]() from the GitHub Release section.
2. Install the plugin template by calling:
```
dotnet new --install JetBrains.ReSharper.SamplePlugin.*.nupkg
```
3. Unpack the template with your preferred plugin name:
```
dotnet new resharper-rider-plugin --name MyPlugin
```
> If your plugin should only target ReSharper, you can pass the `--resharper-only` switch.
>
{type="note"}

> If you plan to use GitHub Actions as your continuous integration/deployment (CI/CD) environment, you can pass the `--github-actions` switch.
>
{type="note"}

</procedure>

### Components of the Template-Generated Plugin

When extracting the template using `MyPlugin` as a name, it will create the following directory content:

```text
MyPlugin
├── .github
│   └── wrapper
│       ├── CI.yml
│       └── Deploy.yml
├── .run
│   ├── rdgen (Unix).run.xml
│   ├── rdgen (Windows).run.xml
│   ├── rdgen.run.xml
│   ├── Rider (Unix).run.xml
│   ├── Rider (Windows).run.xml
│   ├── Rider - Frontend (Unix).run.xml
│   ├── Rider - Frontend (Windows).run.xml
│   ├── Rider.run.xml
│   └── VisualStudio.run.xml
├── gradle
│   └── wrapper
│       ├── gradle-wrapper.jar
│       └── gradle-wrapper.properties
├── protocol
│   ├── src/main/kotlin/model/rider
│   └── build.gradle
├── src
│   ├── dotnet
│   │   ├── ReSharperPlugin.MyPlugin
│   │   │   ├── IMyPluginZone.cs
│   │   │   ├── ReSharperPlugin.MyPlugin.csproj
│   │   │   └── ReSharperPlugin.MyPlugin.Rider.csproj
│   │   ├── ReSharperPlugin.MyPlugin.Tests
│   │   │   ├── ReSharperPlugin.MyPlugin.Tests.csproj
│   │   │   ├── TestEnvironment.cs
│   │   │   └── test
│   │   │       └── data
│   │   │           └── nuget.config
│   │   ├── Directory.Build.props
│   │   └── Plugin.props
│   └── rider/main
│       ├── kotlin/com/jetbrains/rider/plugins/myplugin
│       └── resources
│           └── META-INF
│               └── plugin.xml
├── tools
│   ├── nuget.exe
│   └── vswhere.exe
├── .gitattributes
├── .gitignore
├── CHANGELOG.md
├── README.md
├── ReSharperPlugin.MyPlugin.sln
├── build.gradle
├── buildPlugin.ps1
├── gradle.properties
├── gradlew
├── gradlew.bat
├── publishPlugin.ps1
├── runVisualStudio.ps1
├── settings.gradle
└── settings.ps1
```

* The <path>gradlew</path> and <path>gradlew.bat</path> files to bootstrap running Gradle on Windows, macOS, and Linux. These will also automatically install the required [Amazon Corretto 11 SDK](https://docs.aws.amazon.com/corretto/latest/corretto-11-ug/downloads-list.html) into the <path>build/gradle-jvm</path> directory.
* The <path>build.gradle</path> file to build and deploy the plugin for ReSharper and Rider.
> See the IntelliJ SDK help for more information about [Gradle-Related Plugin Components](https://plugins.jetbrains.com/docs/intellij/gradle-prerequisites.html#components-of-a-wizard-generated-gradle-intellij-platform-plugin).
* The <path>buildPlugin.ps1</path> and <path>publishPlugin.ps1</path> files to build and deploy only the ReSharper plugin.
* The <path>gradle.properties</path>, <path>settings.ps1</path>, <path>plugin.xml</path>, and <path>Plugin.props</path> files, containing information about plugin metadata (id, description, authors), dependency versions (ReSharper/ Rider SDK), and paths to solution and project files.
* The [Run/debug configurations](https://www.jetbrains.com/help/rider/Run_Debug_Configuration.html) for Rider/IntelliJ IDEA (<path>.run</path> directory) and the <path>runVisualStudio.ps1</path> for PowerShell (`--resharper-only` template extraction) to launch the plugin in an experimental instance of Rider or Visual Studio with ReSharper.
* The <path>src/dotnet</path> directory with basic project files for ReSharper and Rider including a test project. The <path>Directory.Build.props</path> defines all common NuGet references for both.
* The <path>README.md</path> and <path>CHANGELOG.md</path> files for documentation about the plugin. The first section of the <path>CHANGELOG.md</path> is automatically included in the plugin metadata. The <path>README.md</path> has predefined [Shields.IO](https://shields.io/) badges with `RIDER_PLUGIN_ID` and `RESHARPER_PLUGIN_ID` as placeholders that can be updated after the first deployment.
* The <path>.github/workflow</path> directory (requires `--github-actions` during template extraction) with predefined workflows for a continuous build (including `Build` and `Test`) and a deployment build.

redpajama_set_name: RedPajamaGithub


I guess always was a clown..at age 12 ...I worked in a small one ring open air circus...After the army I was playing drums and tour with different bands.
At one point I was off the road for awhile I started putting together my first clown character. It made it as a regular on a morning Kiddie TV show called THE OLD REBEL SHOW.
While on that show one morning a clown who was doing the advance for the Blue unit of RBBB was on the show to promote the coming Circus, I think his name was Troy Straight and he invited me to the show and introduced me to Mark Anthony...It would a few years later that I would run into Mark in Orlando doing a magic convention and selling his foam carvings.
He had been fired from the show over a $5.00 pay dispute with Irvin Feld..And was living at Marty and Wayne Scott's home in Howie in the Hills..he invited me to come out for a visit .
To visit Mr. Piccard's myspace page please click the title of this post.
From the A&E special UNDER THE BIG TOP, a look at some of contemporary American circus clowning's leading lights being interviewed about their craft.
We have Jason T. Stewart (Whiteface) as well as 2007 Felix B. Adler Award winners Barry Lubin (Auguste) and Tom Dougherty (Character) with a brief cameo by fellow 2007 winner Greg DeSanto and appearances by Mitch Freddes, Alan Ware and Bryan Fulton.
Dan "Sylvester the Jester" Battagline, A Real Live Cartoon, with more great clown gags per second than 100 circuses.
For more on Sylvester the Jester please click on the title of this post.
Kinko Sunberry performing his comedy contortion act at the Grotto Circus in Toledo, OH "back in the day".
A publicity photo of Earl Shipley. I don't recognize the woman but the photo looks to have been taken towards the end of Earl's long career, when he was doing advance work for Ringling in the 50s.
Left to right Al Florenze, Billy Price, Slivers Johnson, Guby Deko, Jimmy Davidson, Gil Corbin, Rube Simmons, Herb Taylor.
Ed Wynn performs a teeterboard gag with members of the Ringling Bros. and Barnum & Bailey Circus Clown Alley.
Look for Michael "Coco" Poliakovs, "Prince Paul" Alpert, Duane "Uncle Soapy" Thorpe, Gene Lewis and Albert "Flo" White (in his final Ringling season) as the nurse.


text:
Mini ReviewOpen Access
DDHD domain-containing lipases: Targets for the treatment of rare diseases
Pradeep Kumar Yadav1,2 and Ram Rajasekharan1,2*
1Lipidomic Centre, Department of Lipid Science, CSIR-Central Food Technological Research Institute (CFTRI), Mysore 570020, Karnataka, India
2Academy of Scientific & Innovative Research, CSIR-CFTRI, Mysore, India
The DDHD domain-containing lipases belong to the intracellular phospholipase A1 (iPLA1) family. Phospholipases have been implicated in the regulation of lipid metabolism, intracellular membrane trafficking, and signaling. In addition, phospholipases have been linked to the development of rare and neurodegenerative diseases. The rare and neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease have been focused on phospholipase A2. But there is a scarcity of literature on the role of PLA1 in rare and neurodegenerative diseases. Recently, in humans, mutation in DDHD1 and DDHD2 (iPLA1 members) has been identified as a cause of specific types of hereditary spastic paraplegia (HSP) termed as SPG28 and SPG54, respectively. Ddl1 (DDHD domain-containing lipase 1), a yeast homolog of human DDHD1/2, hydrolyzes cardiolipin (CL), phosphatidylethanolamine, and phosphatidylglycerol. Ddl1 has an important role in the mitochondrial phospholipids remodeling. Defects in phospholipids remodeling and mitochondrial functions have been implicated in the development of the Barth syndrome, HSPs, and other neurodegenerative disorders. Mutations in DDHD1 and DDHD2 produce DDL1-defective yeast strain like phenotypes (mitochondrial dysfunction and defects in lipid metabolism).
Therefore, the DDL1-defective yeast could be a good model system to understand hereditary spastic paraplegia.
DDHD domain
The DDHD domain was first identified as a long stretch of amino acids in the central part of the Nir/rdgB (N-terminal domain-interacting receptor/Drosophila retinal degeneration B) proteins1. This domain possesses four conserved amino acid residues (DDHD), which may play an important role in forming a metal-binding site. The name DDHD domain is based on these four conserved amino acid residues. This domain is also found in the C-terminal region of the phosphatidic acid (PA)-preferring phospholipase A1 (PA-PLA1)1. The recently identified lipid-metabolizing enzyme family, named as intracellular phospholipase A1(iPLA1) family also possesses the DDHD domain-containing proteins. It has been predicted that the DDHD domain may play a role in the phospholipid metabolism, organelle biogenesis, membrane trafficking, and signaling1. In humans, there are three iPLA1family members namely PA-PLA1/DDHD1, KIAA0725p/DDHD2 and p125/Sec23IP. The iPLA1 family members have also been reported in yeasts, nematodes, and plants2. The first iPLA1 member, PA-PLA1, was identified by Higgs and Glomset3. The DDHD14and DDHD25 have hydrolase activities, while the lipase activity of p125 is yet to be demonstrated. A study of the substrate specificity of the purified rat DDHD2 provides new insights into the enzymatic nature of the human DDHD26. The human DDHD1 and DDHD2 are the PA preferring lipases and play an important role in the intracellular membrane trafficking. PA has diverse functions in biological systems. It is a precursor for the biosynthesis of polar and non-polar lipids. It has structural functions in the biological membranes7. It has also been reported that PA has an important role in the lipid signaling8. Like iPLA1 family members, the DDHD domain is also conserved in some phosphatidylinositol transfer proteins9,10. Inoue et al. have shown that the DDHD domain is crucial for the PLA1 activity as well as in phosphatidylinositol phosphate (PIP) binding and oligomerization4. PIPs play crucial parts in the membrane trafficking11,12.
Role of phospholipases in rare diseases
Phospholipids are an important constituent of biological membranes. Several studies13-19 have shown that phospholipases play an important role in rare and neurodegenerative diseases. Phospholipases are enzymes that hydrolyze the phospholipids. Phospholipases have been implicated in the processes like regulation of lipid transport and metabolism, intracellular membrane trafficking, and vesicular transport13. Phospholipases are categorized in A, B, C and D groups according to their site of action. Most of the studies related to disease conditions have been focused on phospholipase A2 (PLA2)13-16. As different types of PLA2 have been identified in the central nervous system (CNS); therefore, the role of PLA2s in rare and neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease have been widely studied14-19. But the knowledge regarding the roles of different types of PLA2 is sketchy because of the complexity of the brain which possesses different types of cells. On the other hand, there is a scarcity of reports on the role of PLA1 in rare and neurodegenerative diseases. Recently, in humans, mutations in DDHD1 and DDHD2 (iPLA1 members) have been identified as a cause of specific types of hereditary spastic paraplegia termed as SPG2820 and SPG5421,22, respectively. Hereditary spastic paraplegia (HSP, also known as Strumpell-Lorrain disease) is a heterogeneous group of genetic neurodegenerative disorders, and these disorders are mainly characterized by slowly progressive spasticity (contraction) and weakness of the lower limbs. Many types of HSP have been discovered and are numbered according to the order of their discovery [spastic paraplegia (SPG) 1-72]. Affected individuals are clinically grouped according to the absence (uncomplicated or pure HSP) or presence (complicated or complex HSP) of additional phenotypes23,24. By modes of inheritance, HSPs are grouped as autosomal dominant, autosomal recessive, and X-linked recessive HSPs23,24.
DDHD domain-containing lipase in Saccharomyces cerevisiae
We25 have characterized an unannotated Saccharomyces cerevisiae open reading frame, YOR022C as a Ddl1 (DDHD domain-containing lipase 1). Pairwise sequence alignment showed that yeast Ddl1 has ~33% and ~34% similarities with human DDHD1 and DDHD2, respectively. The Ddl1 is a novel mitochondrial phospholipase of the iPLA1 family (Figure 1) that hydrolyzes important mitochondrial phospholipids, and it has roles in cardiolipin (CL), phosphatidylethanolamine (PE), and phosphatidylglycerol (PG) remodeling. The deletion of the DDL1 gene caused an increase in molecular species with saturated fatty acids while DDL1 overexpression caused an increase in the molecular species with unsaturated fatty acids. In addition, we have shown that Ddl1 has roles in CL degradation. Our findings showed that Ddl1 is a CL-preferring lipase; therefore deletion of the DDL1 gene caused an increase in the CL content while overexpression of the DDL1 gene caused a decrease in the cellular CL content. Also, the CL degradation was affected in the DDL1 deleted cells (monolysocardiolipin to dilysocardiolipin conversion was affected by the deletion of the DDL1 gene), leading to the CL accumulation. On the other hand, the DDL1 overexpression increased the CL degradation leading to reduced CL content. Therefore, optimal regulation and activity of Ddl1 are required for the proper CL metabolism. As CL is the signature phospholipid species of the mitochondria; misregulation of Ddl1 causes mitochondrial dysfunction in yeast25.
Figure 1: Ddl1 and its homologs.
A schematic diagram of the DDHD domain-containing lipase and multiple sequence alignment of two conserved regions: the lipase motif (GXSXG) and DDHD domain. A list of homologs of the iPLA1 family is available on the UniProtKB database. An analysis of the sequences in the PROSITE database showed that the lipase motif is present inside the PROSITE domain PS00120 consensus sequence [LIV]-{KG}-[LIVFY]-[LIVMST]-G-[HYWV]-S-{YAG}-G-[GSTAC]. In some family members, the lipase consensus sequence (GXSXG) was replaced by the SXSXG sequence. In Ddl1, the lipase motif spanned from the 499th to 503rd amino acids, while the DDHD domain spanned from the 519th to 700th amino acids.
Role of mitochondria in rare diseases
The mitochondria are vital organelles of the cell. Important metabolic reactions and the regulation of some signaling cascades occur in the mitochondria26. The mitochondria are sites of synthesis of major non-bilayer-forming phospholipids PE and CL27,28. CL and PE play an important role in the mitochondrial fusion29. CL is required for the proper mitochondrial inner membrane potential Δψ and in protein import into the mitochondria30. CL and mitochondrial PE have overlapping functions, and they can compensate for the loss of the other31. Defective mitochondrial phospholipids remodeling has been identified as a major cause of Barth syndrome32,33. We25 have proposed that CL is remodeled through a deacylation-transacylation cycle, in which the acyl specificity of CL is achieved by extensive remodeling through PLA1 (Ddl1), PLA2 (Cld1), and transacylase (Taz1) activities. A deacylation (by Ddl1)-reacylation (by CoA-dependent acyltransferase, Ale1) cycle was proposed for the PE and PG remodeling in yeast (Figure 2).
Figure 2: A schematic model of the proposed roles of the DDL1 gene in yeast
We propose that Ddl1 plays an important role in phosphatidylethanolamine (PE), phosphatidylglycerol (PG) and cardiolipin (CL) remodeling; as well as CL degradation. Ddl1 overexpression enhances the degradation of the mitochondrial membrane lipids, causing mitochondrial dysfunction in yeast. MLPE, monolysophosphatidylethanolamine; MLPG, monolysophosphatidylglycerol; MLCL, monolysocardiolipin; DLCL, dilysocardiolipin; and LPL, lysophospholipid.
It has been shown that human DDHD1 is partially localized to the mitochondria20,34 and mutations in DDHD1 gene produce mitochondrial dysfunction and defects in lipid metabolism. The DDHD2 protein has been reported to locate in cis-Golgi and endoplasmic reticulum (ER)-Golgi intermediate compartment, besides role of DDHD2 in the membrane trafficking and vesicle fusion has been proposed4. Defects in the intracellular membrane trafficking, mitochondrial morphology and functions, and lipid metabolism are key pathophysiological features of HSPs20,35. The neurodegenerative disorders, such as Alzheimer's disease, and Huntington's disease have also been associated with the defects in the intracellular membrane trafficking, mitochondrial morphology, and functions36. Alteration in the mitochondrial-membrane lipid composition has already been shown to cause mitochondrial dysfunction which in turn triggers secondary cellular dysfunctions37-39. The increased reactive oxygen species (ROS) production was observed in SPG28 and SPG49 cells, and it was hypothesized that the increased ROS production could cause neurodegeneration40.
A Recent study has linked alterations in CL profile to an early development of the age-related neurodegenerative disorders such as Alzheimer's disease41. Human HSD10 is a multifunctional enzyme which is found in the brain and cerebral spinal fluid and has been associated with the mitochondrial disease. In Alzheimer's disease patients, the HSD10 expression was found elevated42. Recently, a study showed that the HSD10 protein has CL-specific phospholipase C-like enzyme activity43.
Cures and future perspectives
In humans, many rare genetic diseases are associated with mutations in poorly characterized genes. Determination of biochemical functions of these genes is critical for understanding and formulating potential cures for these rare genetic diseases. The probable implication of cardiolipin and mitochondria in the pathophysiology of neurodegenerative disorders could help in the development of therapeutic strategies focused on the mitochondrial morphology and functions.
Polyunsaturated fatty acids (PUFAs) are enriched in the phospholipids of CNS membranes44. Metabolism of PUFA is strictly controlled by PLA2 and acyltransferases through "deacylation-reacylation cycle" which is an energy-dependent process involving coenzyme A (CoA) and ATP45-47. We25 have shown that Ddl1 (PLA1), the yeast homolog of human DDHD1 and DDHD2 proteins, plays an important role in the mitochondrial phospholipids remodeling. Therefore, it will be interesting to study the role of DDHD1 and DDHD2 proteins in phospholipids remodeling.
There are several synthetic and phytochemical based inhibitors of PLA2 available and which could be used for the treatment of neurological disorders48. Ginkgo biloba and Centella asiatica extracts have been used for the treatment of neurological disorders in the cell culture and animal model systems49,50. The neurological disorders wherein the PLA2 expression is elevated, PLA2inhibitors could be used for the treatment. Likewise, identification of PLA1 inhibitors would provide a base for the innovative development of therapeutic strategies focused on the PLA1 activities.
Cardiolipin is always at the risk of oxidation as it is localized to the inner mitochondrial membrane. When cardiolipin becomes oxidized, it induces apoptosis and could trigger diseases such as Alzheimer's and Parkinson's. Researchers have suggested that HSD10 protein has CL-specific phospholipase C-like enzyme activity, and it prevents neurodegeneration by removing oxidized cardiolipin43. In humans, mutations in the DDHD1 and DDHD2 genes cause specific types of hereditary spastic paraplegia, and the yeast DDL1-defective strain exhibits the similar phenotypes of hereditary spastic paraplegia (mitochondrial dysfunction and defects in lipid metabolism). Yeast Ddl1 prefers CL as substrates. It has also been shown that DDHD1 is partially localized to the mitochondria20,34. Therefore, it will be interesting to explore the role of DDHD1 in CL metabolism. In addition, the DDL1-defective yeast strain could be a suitable model system to understand hereditary spastic paraplegia.
This study was supported by the Council of Scientific and Industrial Research (CSIR), New Delhi, under the 12th five-year plan project LIPIC. P.K.Y. was supported by a fellowship from CSIR, New Delhi. The corresponding author is a recipient of the JC Bose national fellowship. The authors declare that they have no conflicts of interest.
Lev S. The role of the Nir/rdgB protein family in membrane trafficking and cytoskeleton remodeling. Exp Cell Res. 2004; 297: 1-10.
Tani K, Kogure T, Inoue H. The intracellular phospholipase A1 protein family. Biomol Concepts. 2012; 3: 471-478.
Higgs HN, Glomset JA. Identification of a phosphatidic acid-preferring phospholipase A1 from bovine brain and testis. Proc Natl Acad Sci U S A. 1994; 91: 9574-9578.
Inoue H, Baba T, Sato S, Ohtsuki R, Takemori A, Watanabe T, et al. Roles of SAM and DDHD domains in mammalian intracellular phospholipase A1 KIAA0725p. Biochim Biophys Acta. 2012; 1823: 930-939.
Inloes JM, Hsu KL. The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase. Proc Natl Acad Sci U S A. 2014; 111: 14924-14929.
Araki M, Ohshima N, Aso C, Konishi A, Obinata H, Tatei K, et al. Enzymatic characterization of recombinant rat DDHD2: a soluble diacylglycerol lipase. J Biochem. 2016.
Kooijman EE, Chupin V, de Kruijff B, Burger KN. Modulation of membrane curvature by phosphatidic acid and lysophosphatidic acid. Traffic 2003; 4: 162-174.
Wang X, Devaiah SP, Zhang W, Welti, R. Signaling functions of phosphatidic acid. Prog Lipid Res. 2006; 45: 250-278.
Cockcroft S, Carvou N. Biochemical and biological functions of class I phosphatidylinositol transfer proteins. Biochim Biophys Acta. 2007; 1771: 677-691.
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View/Download pdf
Article Notes
DDHD-domain
Phospholipids remodeling
DDL1
Cardiolipin
Hereditary spastic paraplegia
*Correspondence:
Prof. Ram Rajasekharan
Central Food Technological Research Institute,
Council of Scientific and Industrial Research,
Mysore, Karnataka, India – 570020,
Tel.:+91-821-2517760; Fax: +91-821-2516308; Email: ram@cftri.com
Copyright: ©2016 Rajasekharan R. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License.
Citation: Yadav PK, Rajasekharan R. DDHD domain-containing lipases: Targets for the treatment of rare diseases. J Rare Dis Res & Treatment. (2016) 1(2): 34-38


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2017 MTV RE:DEFINE WEBSITE
ARRESTED MOTION TOP PICKS FOR MTV RE:DEFINE
On behalf of Arrested Motion, editor Khôi Nguyễn gave us his top picks for this year's MTV RE:DEFINE. View and bid on all of the art on Paddle8 through 11:30PM CST April 8th, 2016.
1. Rob Pruitt - Love & Mercy, 2016 - Pruitt's work is often fun, colorful, and playful as he mines and exposes contemporary pop culture. While one of his well-known shaped hearts, this work is also one of his more understated and subdued ones, as it is a monochrome black heart.
2. John Houck - Untitled #195.01, #195.02, 2016 - An instantly recognizable work by Houck, who performs architectural interventions on his works, which explore photography and perception. The bold colored work is simultaneously attractive and conceptually rigorous.
3. Simon de Pury - Le Nombril du Monde, 2009 - The first work of art I have seen available by the Work of Art: The Next Great Artist star and mentor. Usually on the other side, evaluating and judging works to be sold, the iconic auctioneer and art world personality puts himself up for critique as he presents an illustrative piece on navel gazing.
4. Helmut Lang - Untitled, 2015 - Highly acclaimed and admired as a clothing designer, Lang is now a full-time artist on the roster of the esteemed Sperone Westwater gallery. His tall and slender sculptures have the look, feel, and organic sense one would expect from the talented and respected Austrian.
5. Marc Quinn - We Share Our Chemistry With the Stars (XX200), 2016 - art collectors continually strive to have their collections reflect their values, concerns, and personality. One that manifests their discerning eye. What better way to accomplish that than to have a piece that literally is of your eye?


Thubten Chodron ist eine amerikanische Nonne aus der Tradition des tibetischen Buddhismus.
Anger plagues all of us on a personal, national, and international level. Yet, we see people, such as the Dalai Lama, who have faced circumstances far worse than many of us have faced - including exile, persecution, and the loss of many loved ones - but who do not burn with rage or seek revenge. How do they do it? In her talk Ven. Thubten Chodron presents a variety of Buddhist methods for subduing and preventing anger, not by changing what is happening, but by framing it differently. No matter what our religion, learning to work with our anger is effective for everyone seeking personal happiness as well as world peace.


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Mortgage customers with Metro Bank with either a Residential or a Buy to Let mortgage have the option of overpaying on top of their usual monthly payments. By making use of this they could save a considerable amount of interest and may also help to repay their mortgage earlier.
For our Residential mortgage customers they can overpay by 20% a year and up to 10% for our Buy to Let customers. The amount they can overpay each year without incurring any early repayment charges is determined on the initial amount borrowed and then subsequently on what their mortgage balance is each time they switch to a new rate.
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text:
Arthur Lewis
Singer, composer, and pianist from Queens, and a founding member of hip-hop improv comedy group Freestyle Love Supreme. I write indie soul songs, and delight in spontaneous melody and open space.
Singer, composer, and pianist from Queens. I write indie soul songs and delight in spontaneous melody and open space.
There's a certain type of ennui tht can overtake you
Last night at Stevie, te other night with Prince, even last year with dangelo
There's a certain kind of musician I think who needs to write music, not because they need to write, but because they need to hear it. It's self medication, not through process, but through product.
I listen to my heroes and I want them to be more than just the people they are. I want them to be the cure. And when they're not, when they are human imperfect aging versions of themselves, when they seem to be focused on answering their own musical questions instead of mine, it sends me spinning.
That shit where they echoed his riffs at the end of knocks me off my feet.
View comments.
I'm also a developer
I specialize in building tools for musicians. For the past couple years, I've been part of the team at Soundfly, a new kind of music school for today's musician.
Join my email list to find out when I'm playing a show near you.
© 2019 Arthur Lewis
If We Were


Magic: the Gathering is a collectible card game created by Richard Garfield. In Magic, you play the role of a planeswalker who fights other planeswalkers for glory, knowledge, and conquest. Your deck of cards represents all the weapons in your arsenal. It contains the spells you know and the creatures you can summon to fight for you.Card Name: Arlinn Kord // Arlinn, Embraced by the MoonCost: 2RGColor: Multi-ColorCard Type: PlaneswalkerPower/Toughness: 3Card Text: (+1): Until end of turn, up to one target creature gets +2/+2 and gains vigilance and haste. 0: Put a 2/2 green Wolf creature token onto the battlefield. Transform Arlinn Kord. // (+1): Creatures you control get +1/+1 and gain trample until end of turn. (-1): Arlinn, Embraced by the Moon deals 3 damage to target creature or player. Transform Arlinn, Embraced by the Moon. (-6): You get an emblem with "Creatures you control have haste and 'T: This creature deals damage equal to its power to target creature or player.'"


If you or your family members have been issued a Danish passport since February, it may include a vital mistake that makes it invalid for international travel.
Thousands of Danes have been issued invalid passports without obligatory fingerprints, Local Government Denmark (Kommunernes Landsforening - KL) said on Friday.
Passports issued in 44 of Denmark's 98 municipalities after the date of February 2nd are missing biometric fingerprints due to an error made by private company Scantech, KL said.
A total of 10,947 of the flawed passports were issued nationwide.
Those affected by the mistake will be contacted by their municipality but anyone planning to travel in the near future was urged to immediately contact the municipality's citizen services department (Borgerservice).
"The mistake is deeply regrettable as it is a requirement that citizens' passports include a chip with fingerprints. If the affected citizens are due to travel abroad in the near future, they can contact the municipality's citizen services centre for more information on what to do," KL said in a statement.
KL said that the Danish National Police (Rigspolitiet) discovered the mistake and informed the affect municipalities.
Scantech blamed the error on a software update and the company said it would cover the costs of a new passport.
A company spokesman said that despite the passports not including the necessary fingerprints, some Danes may have already successfully travelled with them.
"You can imagine that there have been citizens who have travelled with these passports and never realized that something was wrong. But that doesn't change the fact that the passports should be correct and therefore anyone affected should get a new passport," Henrik Kromann told broadcaster DR.
Without the fingerprints however, travellers do face the possibility of being denied legal entry at their destination.
Denmark has had biometric passports since 2012 that require the fingerprints.


Creek Cruises offers excitement and entertainment of a vastly different kind for the Dubai Visitors. Aboard our traditional Arabic Dhow you can set out on a pleasure trip down the creek that will be a special way to admire the city's skyline and more importantly cherish the precious moments with your dear ones.
We are guest-centric with our 'Excellence' department looking after every detail including information, itinerary and continuing to check them on a periodic basis.


Cooking is certainly enjoyable. It is also one component that lots of people need to learn because we always deal with food each day. We please us with this particular good cooking skills we impress our partners with great dinners you need to prepare to reside in to make sure we maintain a healthy diet plan indeed, cooking is really a factor you need to learn and also you want to make it happen good.
Everyone has their very own practices with the cooking which will make our cooking easy and simple , touring. The higher we prepare the higher putting them to use we uncover. If you are trying to find many putting them to use to improve your list, listed here are some which you might find helpful.
* If you want to organize ahead of time and store food in freezers, ensure to understand what your meals are dangerous towards the freezer. Don't freeze steamed eggs, because you can get the egg-whites to obtain watery. Freezing might also result in the mayonnaise to part ways and milk to curdle.
* Freezing may also be not friendly to cooked taters, since it will darken them making an unattractive texture. To keep the color of sliced taters, place them cold water until they are prepared to prepare. This will usually increase its crispiness if you are planning to fry them. You may even whiten them by putting a few drops of lemon during boiling.
* To improve the flavour of stewed chicken, let it stay at home its broth until it cools lower before performing into chunks.
* If you are barbequing, brush the grate with oil or spray with vegetable cooking spray to prevent the bbq from sticking. When fire flares up during barbequing, sprinkle somewhat water inside the flames. Make certain and to remove the bbq before the fire will burn the whites in the meat. To lessen overbrowning from the bbq, you'll be able to make use of the sauce only 20 minutes before it's done.
* You'll be able to drop lettuce leaves within your soups, gravies as well as other dishes to get rid of the extra oil. You will see the oil will easily cling to the leaves to be able to easily get rid of them.
* When baking cookies, you should make similar shapes and sizes to be able to put them in even rows and they'll heat evenly. Large spaces one of the cookies can cause them to burn. Don't also leave cookies inside the hot baking sheet after they are cooked as this continuously prepare or may copy.
There are many putting them to use that individuals can definitely learn once we spend time with the cooking. They don't only make our cooking easy, it is also very useful to preserve the nutrients, the color and texture combined with the flavor within our food. Knowing some putting them to use helps as well us a great learn the ability of cooking.


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Start Over You searched for: Collections Medicine in the Americas, 1610-1920 ✖Remove constraint Collections: Medicine in the Americas, 1610-1920 Subjects Physicians ✖Remove constraint Subjects: Physicians Genre Eulogies ✖Remove constraint Genre: Eulogies
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1. Addresses commemorative of James L. Cabell: delivered at the University of Virginia, July 1, 1890
Charlottesville, Va. : Chronicle & C.M. Brand, 1890
Cabell, J. L. (James Lawrence), 1813-1889.
2. Memoir of George McClellan, M.D: a lecture introductory to the course of the theory and practice of physic in the Medical Department of Pennsylvania College, for the session of 1847-48
Darrach, William, 1796-1865
Philadelphia : King & Baird, printers, 1847
McClellan, George, 1796-1847.
3. A discourse commemorative of the late Professor T.D. Mütter, M.D., LL.D: being the introductory lecture to the course of anatomy in the Jefferson Medical College of Philadelphia, delivered October 14, 1859
Pancoast, Joseph, 1805-1882
Philadelphia : Joseph M. Wilson, 1859
Mütter, Thomas D. (Thomas Dent), 1811-1859.
4. Memorial of Prof. Charles Hooker, M.D: the inaugural address of Leonard J. Sanford, M.D., as professor of anatomy and physiology in Yale College, delivered, September 17th, 1863
Sanford, Leonard J. (Leonard Jacob), 1833-1896
New Haven : Thomas H. Pease, 1863
Hooker, Charles, 1799-1863.
5. An eulogy on Dr. Godman: being an introductory lecture, delivered November 1, 1830
Sewall, Thomas, 1786 or 1787-1845
Washington : Wm. Greer, Printer, 1830
Godman, John D. (John Davidson), 1794-1830.
6. Obituary: died in Boston, March 27, 1834, at the residence of his father, Dr. Jackson, James Jackson, Jr. M.D. aged twentyfour
[United States? : s.n., 1834?]
Jackson, James, 1810-1834.
7. Eulogy on James Macdonald, M.D: delivered before the New-York Medical and Surgical Society
Swett, John A. (John Appleton), 1808-1854
New York : D. Fanshaw, printer, 1849
Macdonald, James, 1803-1849.
8. Eulogy on Richard Sharp Kissam A.M., M.D: read before the New York Academy of Medicine, December 3d, 1862
Gardner, Augustus K. (Augustus Kinsley), 1821-1876
New York : C.A. Alvord, printer, 1863
Kissam, Richard S. (Richard Sharp), 1806-1861.
9. Biographical notice of the late J. Greely Stevenson, M.D
[Boston? : D. Clapp, Jr., printer, 1835?]
Stevenson, J. G. (Jonathan Greely), 1799-1835.
10. A memorial of the late Robley Dunglison, M.D: one of the vice-presidents of the Pennsylvania Institution for the Instruction of the Blind : prepared in compliance with a resolution of the board of managers
Peale, Franklin, 1795-1870, author
Philadelphia : Collins, printer, 1869
Dunglison, Robley, 1798-1869.
11. In memory of Dr. Samuel G. Armor: born January 29, 1819, died October 27, 1885
Cleveland, Ohio : Clark-Britton Print. Co., 1886
Armor, Samuel G. (Samuel Glasgow), 1819-1885.
12. In memoriam, Francis Asbury Ashford, M.D: born September 19, 1841, died May 19, 1883
Washington Obstetrical and Gynaecological Society, author.
Washington, D.C. : Gibson Brothers, printers, 1883
Ashford, Francis Asbury, 1841-1883.
13. Memoir of Henry Jacob Bigelow
Holmes, Oliver Wendell, 1809-1894, author
Cambridge : John Wilson and Son, 1891
Bigelow, Henry Jacob, 1818-1890.
14. Proceedings of the special meeting of the Medical and Chirurgical Faculty of Maryland in relation to the death of Dr. Riggin Buckler: held September 5th, 1884
Medical and Chirurgical Faculty of the State of Maryland, author.
Baltimore : Journal Publishing Company Print., 1884
Buckler, Riggin, 1831-1884.
15. In memoriam
Chicago : Press of Shea Smith & Co., [1894?]
Earle, Charles Warrington, 1845-1893.
16. Serving our generation: a discourse commemorative of the life work of John D. Ford : delivered in the First Baptist Church, Winona, Minnesota, Sabbath, November 3d, 1867
Stone, Geo. M. (George M.), author
Winona : Green & Gile, printers, 1867
Ford, John D. (John Deming), 1816-1867.
17. In memoriam, James Crowdhill Hall, M.D: born January 10, 1805, died June 7, 1880
Children's Hospital (Washington, D.C.), author.
Hospitals, Pediatric
Hall, James Crowdhill, 1805-1880.
18. Eulogy delivered before the New York State Medical Association on Prof. Frank Hastings Hamilton, M.D., LL. D: New York, November, 1886
Leale, Charles A. (Charles Augustus), 1842-1932, author
Concord, N.H. : Republican Press Association, 1887
Hamilton, Frank Hastings, 1813-1886.
19. Biographical memoir of Hugh L. Hodge, M.D., LL.D: prepared at the request of the Philadelphia County Medical Society and read before the society, April 22, 1874
Goodell, William, 1829-1894, author
Hodge, Hugh L. (Hugh Lenox), 1796-1873.
20. The late Alden March, M.D: a paper read at a meeting of the Elmira Academy of Medicine on the evening of August 3d, 1869
Wey, William C., 1829-1897, author
[Elmira, N.Y.] : [publisher not identified], [1869?]
March, Alden, 1795-1869.
21. The life and character of Alden March, M.D: an address delivered before the Albany County Medical Society, at its annual meeting, Nov. 9, 1869
Babcock, James L. (James Leonard), 1825-1881, author
Albany : Weed, Parsons and Company, printers, 1871
22. Eulogy on the late Valentine Mott, M.D., LL. D
Post, Alfred C. (Alfred Charles), 1806-1886, author
New York : Messrs. Baillière Brothers, 1866
Mott, Valentine, 1785-1865.
23. Memoir of Dr. James Moultrie: late professor of physiology in the Medical College of the State of South Carolina, and member of the Medical Society of South Carolina : being the report of a committee of the Medical Society, specially charged with the duty of preparing it
Wragg, William T., 1807-1885, author
Medical Society of South Carolina, author.
Charleston, S.C. : William G. Mazyck, printer, 1869
Moultrie, James, Jr., 1793-1869.
24. Proceedings of the second joint meeting: held at Columbia College, Monday evening, March 27, 1893, in memory of Professor John Strong Newberry
Scientific Alliance of New York, author.
New York : Press of L.S. Foster, 1893
Newberry, J. S. (John Strong), 1822-1892.
25. Address of Prof. N.R. Smith before the Medical and Chirurgical Faculty of Maryland
Smith, N. R. (Nathan Ryno), 1797-1877, author
Baltimore : Printed by Kelly, Piet & Co., 1870
O'Donovan, John H., 1802-1869.
26. Scripture and hymns used at the funeral of Deacon Samuel C. Paine, M.D., April 4, 1888: also, sermon preached at the memorial service, in the Congregational Church, Oxford, Mass., April 8th, 1888
Dean, William N. T., author
Worcester : Press of Chas. Hamilton, 1888
Paine, Samuel C. (Samuel Chandler), 1807-1888.
27. Memoir of the late William C. Roberts, M.D: vice-president of the New York Academy of Medicine, etc
Smith, Gouverneur M. (Gouverneur Mather), author
New York : Anson D.F. Randolph & Company, 1874
Roberts, William C. (William Currie), 1810-1873.
28. Tribute to the late James Marion Sims, M.D., LL. D
Baldwin, W. O. (William Owen), 1818-1886, author
Montgomery, Ala. : W.D. Brown & Co., 1884
Sims, J. Marion (James Marion), 1813-1883.
29. Illustrious brother Anthony Eugene Stocker, M.D., 33°: born in Philadelphia, Pa. March 5th, 1819, died at Philadelphia, Pa. May 23d, 1897
Kendrick, George W., Jr., author
[Philadelphia?] : [publisher not identified], [1897?]
Stocker, Anthony Eugene, 1819-1897.
30. A memorial of Dr. James Vanderpool: of Newark, New Jersey, who died at Yokohama, Japan, January 14, 1876, in the thirty-fifth year of his age, while on a voyage around the world
Newark, New Jersey : Printed by Ward & Tichenor, December 1876
Vanderpool, James, 1841-1876.
31. History of the memorial fountain: erected to the memory of Roderick Adams White, M.D. by his wife Elizabeth Hungerford White and the dedicatory service, Sept. 6, 1892
Hartford, Conn. : Press of the Case, Lockwood & Brainard Company, 1893
Anniversaries and Special Events
White, Roderick Adams, 1809-1887.
32. Sermon preached by Rev. Edmund B. Willson: at the North Church, Salem, Sunday, March 5, 1893
Willson, E. B. (Edmund Burke), 1820-1895., author
Salem, Mass. : Printed by Salem Press Publishing and Printing Co., [1893?]
Wheatland, Henry, 1812-1893.
33. The good physician, Dr. Joseph O. West: born in Barnstead, N.H., June 21, 1823, died in Princeton, Mass., January 28, 1887
Boston : Blair & Hallett, printers, 1887
West, Joseph O., 1823-1887.
34. Memorial of Dr. A.M. Wilder
San Francisco Medical Benevolent Society, author.
[San Francisco?] : [publisher not identified], [1886?]
Wilder, A. M. (Abraham M.), 1840-1886.
35. Tribute to the memory of the late Caspar Wistar, M.D: professor of anatomy, &c. in the University of Pennsylvania, president of the American Philosophical Society for the Promotion of Useful Knowledge, &c
Hosack, David, 1769-1835
New-York : Printed by C.S. Van Winkle, printer to the University, no. 101, Greenwich-Street, 1818
Wistar, Caspar, 1761-1818.
36. An eulogy on the character of John Warren, M.D. president of the Massachusetts Medical Society, professor of anatomy and surgery in Harvard University, A.A.S. &c. &c
Jackson, James, 1777-1867
Boston : Printed by C. Stebbins, 1815
Warren, John, 1753-1815.
37. An eulogium upon Benjamin Rush, M.D., professor of the institutes and practice of medicine and of clinical practice in the University of Pennsylvania: who departed this life April 19, 1813, in the sixty-ninth year of his age : written at the request of the Medical Society of South Carolina, and delivered before them and others, in the Circular Church of Charleston, on the 10th of June, 1813, and published at their request
Ramsay, David, 1749-1815
Philadelphia : Published by Bradford and Inskeep ; and Inskeep and Bradford, New York ; James Maxwell, printer, 1813
Rush, Benjamin, 1746-1813.
38. An eulogium in honor of the late Dr. William Cullen, professor of the practice of physic in the University of Edinburgh: delivered before the College of Physicians of Philadelphia, on the 9th of July, agreeably to their vote of the 4th of May, 1790
Rush, Benjamin, 1746-1813
Philadelphia : Printed by Thomas Dobson, bookseller at the stone house in Second Street, MDCCXC [1790]
Cullen, William, 1710-1790.
39. An eulogium in commemoration of Doctor Caspar Wistar, late president of the American Philosophical Society held at Philadelphia for Promoting Useful Knowledge: delivered before the Society, pursuant to their appointment, in the German Lutheran Church in Fourth Street, in the city of Philadelphia, on the 11th day of March,1818
Tilghman, William, 1756-1827
Philadelphia : Published by E. Earle ..., 1818
Anatomists
40. Eulogium upon the life, professional labors and public services of Joseph Mather Smith, M.D: delivered before the New York Academy of Medicine, Wednesday evening, Feb. 6, 1867
Roberts, William C. (William Currie), 1810-1873, author
New York : Anson D.F. Randolph, 1867
Smith, Joseph Mather, 1789-1866.
41. Eulogy upon the life and character of Hiram Augustus Edmonds, M.D., sup't of the Lydius St. Mission Sabbath School: delivered before the teachers and friends of the mission on Wednesday evening, April 29, 1857
Willard, Sylvester David, 1825-1865
Albany, N.Y. : J. Munsell, 1857
Edmonds, Hiram Augustus, 1824-1857.
42. Biographical memoir of Thomas Spencer, M.D., professor of the theory and practice of medicine, &c: read before the Medical Society of the State of New-York, February 2d, 1858
Albany : Van Benthuysen, printer, 1858
Spencer, Thomas, 1793-1857.
43. Biographical memoir of Casper Van Wie Burton, M.D., of Lansingburgh
Troy, N.Y. : Troy Daily Times Print, 1861
Burton, Casper Van Wie, 1810-1860.
44. An obituary notice of Thomas T. Hewson, M. D: late president of the Philadelphia College of Physicians
Bache, Franklin, 1792-1864
Philadelphia : Geddes, 1850
Hewson, Thomas Tickell, 1773-1848.
45. Eulogium on Doctor William Shippen: delivered before the College of Physicians of Philadelphia, March, 1809
Wistar, Caspar, 1761-1818
Philadelphia : Published by Thomas Dobson and Son, at the Stone House, no. 41, South Second Street ; William Fry, printer, 1818
Shippen, William, 1736?-1808.
46. A sermon, preached at the Church in Brattle Square, Boston, on the Lord's day after the decease of John Warren, M.D. Hersey Professor of Anatomy and Surgery in the University at Cambridge, president of the Massachusetts Medical Society, corr. member of the Lond. Medical Society &c. &c. &c. who died IV. April, MDCCCXV. aged LXII
McKean, Joseph, 1776-1818
Boston : Printed by John Eliot, 1815
47. An oration occasioned by the death of John Warren, M.D. past Grand Master: delivered in the Grand Lodge of Massachusetts, at a quarterly meeting, in Boston, June 12, 1815 ; in presence of the supreme executive of the commonwealth, the president of the Senate, the speaker of the House of Representatives, the judges, the corporation and instructors of Harvard University ; the officers of the American Academy of Arts and Sciences ; of the Massachusetts Medical Society ; and of the Humane Society ; the clergy, selectmen, &c
Bartlett, Josiah, 1759-1820
Boston : Printed by C. Stebbins, for Russell, Cutler & Co., 1815
48. Eulogy on the life and character of Theodric Romeyn Beck, M.D., LL. D: delivered before the Medical Society of the State of New-York
Hamilton, Frank Hastings, 1813-1886
Albany : Printed by C. Van Benthuysen, 1856
Beck, Theodric Romeyn, 1791-1855.
49. Biographical sketch of Amariah Brigham, M.D: late superintendent of the New York State Lunatic Asylum, Utica, N.Y
Hunt, E. K. (Ebenezer Kingsbury), 1810-1889
Utica, N.Y. : McClure, 1858
Brigham, Amariah, 1798-1849.
50. An eulogium on William P. Dewees, M.D: delivered before the medical students of the University of Pennsylvania, November 5, 1842
Hodge, Hugh L. (Hugh Lenox), 1796-1873
Philadelphia : Merrihew & Thompson, printers, 1842
Dewees, William P. (William Potts), 1768-1841.
51. A tribute to the memory of Jacob Dyckman, M.D., late health commissioner of the city of New-York, &c: being a discourse pronounced by his friend, Henry William Ducachet, M.D., on Monday, January 6th, 1823, by order of the Medico-Chirurgical Society of New-York, and published by their request
Ducachet, Henry William, 1796-1865
New-York : Printed by T. and J. Swords, 1823
Dyckman, Jacob, 1788-1822.
52. Corona fúnebre del Sr. Dn. Pedro Escobedo, ó sea, Colección completa de todas las producciones literariare, publicadas con motivo de su muerte
[Mexico?] : Imprenta Lito. de Cumplido, [1844?]
Escobedo, Pedro, 1798-1844.
53. The beloved physician: a sermon occasioned by the death of Joseph Warren Fearing, M.D. : preached in the Beneficient Congregational Church, Providence, December 7th, 1862
Clapp, A. Huntington (Alexander Huntington), 1818-1899
Providence : Knowles, Anthony & Co., printers, 1862
Fearing, Joseph Warren, 1800-1862.
Luke, Saint.
54. Proceedings of the general meeting of the medical profession in relation to the deaths of Charles Frick, M.D. and Berwick B. Smith, M.D: held Thursday, March 29th, 1860
Baltimore : Printed by John Murphy, 1860
Frick, Charles, 1823-1860.
Smith, Berwick B.
55. Eulogium, commemorative of Jason O'B. Lawrance, M.D: delivered at the request of his class
Jackson, Samuel, 1787-1872
Philadelphia : Printed by William Fry, 1824
Lawrance, J. O'B. (Jason O'Brien), 1791-1823.
56. An address on the life and professional character of Samuel A. Latta, M.D
Wright, M. B. (Marmaduke Burr), 1803-1879
[Cincinnati? : s.n., 1852?]
Latta, S. A. (Samuel Arminius), 1804-1852.
57. Eulogy on the life and character of the Hon. Samuel Latham Mitchill, M.D: delivered at the request of the New-York City and County Medical Society, in the Superior Court Room, City Hall, October 15th, 1831
Pascalis Ouviere, Felix, 1762-1833
New-York : American Argus Press, 1831
Mitchill, Samuel L. (Samuel Latham), 1764-1831.
58. The benefactors of the Medical School of Harvard University: with a biographical sketch of the late Dr. George Parkman : an introductory lecture, delivered at the Massachusetts Medical College, November 7, 1850
Holmes, Oliver Wendell, 1809-1894
Boston : Ticknor, Reed, and Fields, 1850
Parkman, George, 1790-1849.
Harvard Medical School.
59. Eulogy on the late James M. Pendleton, M.D: delivered by appointment of the New-York City and County Medical Society, in the hall of Columbia College, February 9th, 1832
Bedford, Gunning S., 1806-1870
New-York : John Watt, printer, 1832
Pendleton, James Murison, 1796-1832.
60. An address, occasioned by the death of Nathan Smith, M.D., first lecturer in the Medical School of Maine at Bowdoin College : delivered by appointment of the Faculty of Medicine, March 26, 1829
Allen, William, 1784-1868
Brunswick [Me.] : G. Griffin, printer, 1829
Smith, Nathan, 1762-1829.
61. The beloved physician: a sermon occasioned by the death of the Rev. Austin H. Wright, M.D. : preached to the families of the Nestorian Mission at Oroomiah, Persia, Feb. 8th, 1865
Perkins, Justin, 1805-1869
New York : Edward O. Jenkins, printer, 1865
Religious Missions
Wright, Austin H. (Austin Hazen), 1811-1865.
62. A biographical memoir on the late John Revere, M.D
Mott, Valentine, 1785-1865
New York : Joseph H. Jennings ..., 1847
Revere, John, 1787-1847.
63. Eulogy on Samuel McClellan, M.D: prepared by order of the Medical Society of the State of New-York, and read at the Annual Meeting in Albany, February 3, 1857
Blatchford, Thomas W. (Thomas Windeatt), 1794-1866
Albany : C. Van Benthuysen, 1857
McClellan, Samuel, 1787-1855.
64. Biographical notice of the late John Ruan, M. D: read (by appointment) before the College of Physicians of Philadelphia
Bond, Henry, 1790-1859
Philadelphia : W. F. Geddes, 1845
Ruan, John, 1771-1845.
65. A memoir of the life and character of James B. Rogers, M.D., professor of chemistry in the University of Pennsylvania
Carson, Joseph, 1808-1876
Philadelphia : T. K. & P. G. Collins, 1852
Rogers, James B., 1803-1852.
66. Eulogy on the death of John Doane Wells, M.D: late professor in the Berkshire Medical Institution, delivered before the Faculty and Medical Class, September, 1830
Childs, Henry H. (Henry Halsey), 1783-1868
Pittsfield : P. Allen & Son, [1830]
Wells, John Doane, 1799-1830.
67. Memoir of John W. Francis, jun
[New York : s.n., 1855]
Francis, John W. (John Ward), 1832-1855.
68. Biographical memoir of William Draper Brincklé, M. D: as read, on invitation, before the Pennsylvania Horticultural Society, March 24th, 1863
Gardette, Emile B. (Emile Blaise) 1803-1887
Philadelphia : C. Sherman, Son & Co., 1863
Brincklé, William Draper, 1798-1862.
69. Eulogy on John W. Francis: delivered before the New York Medico-Chirurgical College, March 7, 1861
New York : Published by order of the College, 1861
Francis, John W. (John Wakefield), 1789-1861.
70. A discourse delivered in the First Church, Dorchester, on the Sunday succeeding the funeral of Robert Thaxter M.D
Hall, Nathaniel, 1805-1875
Boston : E. Clapp, 1852
Thaxter, Robert, 1776-1852.
71. Memoir of Moreton Stillé, M. D: read before the College of Physicians of Philadelphia, April 2, 1858
Hollingsworth, Samuel L.
Stillé, Moreton,
72. An address delivered at the funeral of John Gorham, M.D: on the 31st day of March, 1829, by the appointment of the Boston Medical Association, and published at their request
Boston : Boston Daily Advertiser, 1829
Gorham, John, 1783-1829.
73. An address at the funeral of Eli Ives, M.D: October 10th, 1861
Dutton, Samuel W. S. (Samuel William Southmayd), 1814-1866
New Haven : Printed by Thomas J. Stafford, 1861
Ives, Eli, 1779-1861.
74. Funeral oration: delivered before the citizens of Boston assembled at the Old South Church, Nov. XVII. at the burial of Gaspar Spurzheim
Follen, Charles, 1796-1840
Boston : Marsh, Capen & Lyon, 1832
Spurzheim, J. G. (Johann Gaspar), 1776-1832.
75. A discourse commemorative of Nathaniel Chapman, M.D: delivered before the trustees, the medical faculty, and students of the University of Pennsylvania
Philadelphia : T.K. and P.G. Collins ..., 1854
Chapman, Nathaniel, 1780-1853.
76. An address on the life and character of Robert M. Porter, M.D., late professor of anatomy in the University of Nashville: delivered at Nashville, Nov. 8, 1856
Lindsley, John Berrien, 1822-1897
Nashville, Tenn. : Printed by E. Vallette, 1856
Porter, Robert M. (Robert Massengill), 1818-1856.
77. An address on the life and character of Robert M. Porter: delivered at Nashville, Nov. 8, 1856
78. Memoir of John A. Swett, M.D
McCready, B. W. (Benjamin William), 1813-1892
New York : D. Appleton & Co., 1855
Swett, John A. (John Appleton), 1808-1854.
79. A comprehensive minute, commemorative of Philip Syng Physick, M.D., emeritus professor of anatomy and surgery in the University of Pennsylvania
Meredith, William M. (William Morris), 1799-1873
Philadelphia : [s.n.], 1838
Physick, Philip Syng, 1768-1837.
80. A biographical notice of Daniel Drake, M.D., of Cincinnati: prepared by appointment of the College of Physicians of Philadelphia
Meigs, Charles D. (Charles Delucena), 1792-1869
Philadelphia : Lippincott, Grambo & Co., 1853
Drake, Daniel, 1785-1852.
81. Eulogy on the late John W. Francis, M.D., LL.D: being a discourse on his life and character delivered before the New York Academy of Medicine, May 29, 1861
New York : S.S. & W. Wood, 1861
82. Memorial of Dr. William Wesselhöft: to which is added his last address to the Homoeopathic Association
Boston : N.C. Peabody, 1859
Wesselhöft, William, 1794-1858.
83. A sermon preached at Seekonk, Mass., March 12th, 1825: occasioned by the death of Alva Carpenter, son of Deacon Elihu Carpenter, of Seekonk, who departed this life at Mobile, Alabama, November 30th, 1824, in the 27th year of his age
Pierce, Willard, 1790-1860
Providence : Barnum, Field & Co., printers, 1825
Carpenter, Alva, 1798-1824.
84. Eulogium on the late Wright Post, M.D: delivered in the chapel of Columbia College, at the request of the Medical Society of the City and County of New York, on Wednesday, October 8, 1828
Smith, John Augustine, 1782-1865
New York : C.S. Francis, 1828
Post, Wright, 1766-1828.
85. A discourse, commemorative of the life and religious experience of the late David S.C.H. Smith, M.D., of Providence, R.I., formerly of Sutton, Mass: delivered in the Congregational Church, Sutton, April 24, 1859
Lyman, George, Rev
Worcester [Mass.] : Printed by Edward R. Fiske, 1859
Smith, David S. C. H. (David Solon Chase Hall), 1795-1859.
86. An eulogium on Caspar Wistar, M.D., professor of anatomy
Caldwell, Charles, 1772-1853
Philadelphia: : Published by Thomas Dobson and Son ..., 1818
87. An eulogium to the memory of Dr. Samuel Cooper: delivered, by appointment, before the Philadelphia Medical Society, on the fourth day of March, 1799
Philadelphia : Printed by Henry Tuckniss, for Mathew Carey ..., 1799
Cooper, Samuel, 1772-1798.
88. Extract from An eulogium on William Shippen, M.D
Philadelphia : Printed for the publisher, 1818
89. A discourse, delivered at the First Church in Boston, 19th April, A.D. 1795, the Lord's-Day after the interment of Nathaniel W. Appleton, M.D
Clarke, John, 1755-1798
Boston : Printed by Samuel Hall, 1796
Appleton, Nathaniel Walker, 1755-1795.
90. Elegiac poem, on the death of Dr. Benjamin Rush: professor of the institutes and practice of medicine and of clinical practice in the University of Pennsylvania ; who fell a victim to the prevailing typhus fever, on the 19th of April, 1813
Philadelphia : Published by Anthony Finley, southeast corner of Chesnut and Fourth streets ; William Fry, printer, 1813
91. In memoriam William Pepper
Osler, William, Sir, 1849-1919, author
[Philadelphia?] : [publisher not identified], [1899]
Pepper, William, 1843-1898.
92. A memorial of William W. Wellington, M.D., of Cambridge: read before the Cambridge Medical Improvement Society, 28th December, 1896
Wyman, Morrill, 1812-1903, author
[Watertown, Mass.?] : [publisher not identified], 1897
Wellington, William W. (William Williamson), 1814-1896.
93. Huxley and his work
Gill, Theodore, 1837-1914
Washington : G.P.O., 1896
Anatomy, Comparative
Huxley, Thomas Henry, 1825-1895.
94. Dr. Francis Boott
Gray, Asa, 1810-1888, author
[New Haven?] : [publisher not identified], [1864?]
Boott, Francis,
95. Eulogium on Valentine Mott, M.D., LL. D
Bedford, Gunning S., 1806-1870, author
[New York?] : [publisher not identified], [1866?]
96. Necrology
Dickson, Samuel Henry, 1798-1872, author
97. Memorial address: Prof. David S. Conant, M.D. : delivered to the graduating class, in the Medical Department of the University of Vermont
Crosby, A. B. (Alpheus Benning), 1832-1877
Burlington : Times Book and Job Office, 1866
Conant, David S. (David Sloan), 1825-1865.
98. Obituary
[United States : s.n., 1877?]
Freer, J. W. (Joseph Warren), 1816-1877.
99. Necrological: the late Surgeon-General Crane, U.S. Army
Brown, Harvey E. (Harvey Ellicott), 1840-1889
[New Orleans : s.n., 1883?]
Crane, Charles Henry, 1825-1883.
100. Memorials of Dr. Calvin Ellis, M.D
Ellis, Calvin, 1826-1883.
Medicine in the Americas, 1610-1920✖[remove]125
Physicians✖[remove]125
Philadelphia21
Massachusetts13
Faculty, Medical7
Caldwell, Charles, 1772-18533
Willard, Sylvester David, 1825-18653
Gardner, Augustus K. (Augustus Kinsley), 1821-18762
Jackson, James, 1777-18672
Jackson, Samuel, 1787-18722
Memoir of Samuel D. Gross, M.D., LL.D., D.C.L., emeritus professor of surgery in the Jefferson Medical College of Philadelphia2
A biographical memoir on the late John Revere, M.D1
A biographical notice of Daniel Drake, M.D., of Cincinnati: prepared by appointment of the College of Physicians of Philadelphia1
A biographical sketch of the late Middleton Goldsmith, M.D., LL. D1
A comprehensive minute, commemorative of Philip Syng Physick, M.D., emeritus professor of anatomy and surgery in the University of Pennsylvania1
Text125
Eulogies✖[remove]125
Addresses6
Sermons2
Public domain125


Mindful awareness works by enabling you to pay closer attention to what is happening within you—your thoughts, feelings, and emotions—so you can better understand what is happening to you. The Mindful Child extends the vast benefits of mindfulness training to children from four to eighteen years old with age-appropriate exercises, songs, games, and fables that Susan Kaiser Greenland has developed over more than a decade of teaching mindful awareness to kids. These fun and friendly techniques build kids' inner and outer awareness and attention, which positively affects their academic performance as well as their social and emotional skills, such as making friends, being compassionate and kind to others, and playing sports, while also providing tools to manage stress and to overcome specific challenges like insomnia, overeating, ADHD, hyper-perfectionism, anxiety, and chronic pain. When children take a few moments before responding to stressful situations, they allow their own healthy inner compasses to click in and guide them to become more thoughtful, resilient, and empathetic. The step-by-step process of mental training presented in The Mindful Child provides tools from which all children—and all families—will benefit.


text:
Az Abbey Road Studios az EMI 1931 novemberében megnyílt londoni hangstúdiója, ami olyan zenészek révén vált világhírűvé, mint a The Beatles, Cliff Richard, Al Stewart, a Pink Floyd és a Shadows. A stúdió a St John's Wood-i Abbey Roadon található, Westminsterben.

A stúdió története

Az 1831-ben épült György-korabeli lakóházat a Gramophone Company 1931-ben vásárolta meg, és stúdiókat alakított ki benne. A szomszédos ház szintén a stúdió tulajdona, ahol az épp ott dolgozó zenészek szállhatnak meg. Az 1900-as évek közepén Sir Malcolm Sargent karmester gyakran használta a stúdiót, amitől csak egy saroknyira lakott.

A Gramophone Company később egyesült a Columbia Graphophone Companyvel, létrehozva ezzel az EMI-t. A stúdió hivatalos neve 1970-ig csupán EMI Studios volt, ekkor vette fel az Abbey Road nevet.

A 2. stúdió 1958-ban vált a rockzene egyik központjává: Cliff Richard és The Drifters nevű zenekara (később Cliff Richard and The Shadows) ekkor vette fel Move It című dalát, az első európai rock and roll-kislemezt. Ugyancsak itt dolgozott a Beatles; az 1960-as évek közepéig Cliff Richarddal és a Shadows-zal szinte a stúdió kizárólagos tulajdonosaivá váltak. A két zenekar között barátságos küzdelem folyt a stúdióidőért.

A Beatles a későbbiekben rengeteg új felvételi technikát dolgozott ki, kiterjesztve ezzel az akkori könnyűzene határait. Az új effektek közé tartozott a flanging, a visszafelé felvett zene, az automatikus duplázás (ADT) és a feedback (visszacsatolás).

Az itt dolgozó zenekarok közül kétségkívül a Beatles a leghíresebb. 1962 és 1970 között szinte minden dalukat itt vették fel. 1969-es albumukat a stúdió előtti utcáról nevezték el (a stúdiót pedig 1970-ben az albumról). A borítón látható képet Iain MacMillan készítette 1969. augusztus 8-án. A stúdió előtti gyalogátkelőhely hamarosan a Beatles-rajongók zarándokhelyévé vált. Gyakran firkálják össze a stúdió kerítését, az utcanévtáblákat pedig rendszeresen ellopják.

Szintén itt alkotott a Pink Floyd egészen az 1970-es évek közepéig. Itt vették fel a The Piper at the Gates of Dawn (1967), az A Saucerful of Secrets (1968), a Music from the Film More (1969), az Ummagumma (1969), az Atom Heart Mother (1970), a Meddle (1971), a The Dark Side of the Moon (1972-1973) és a Wish You Were Here (1975) című albumokat. Következő itteni munkájuk a Delicate Sound of Thunder (1988) című koncertalbum keverése és a The Division Bell (1994) néhány rájátszása volt. David Gilmour 2006-ban megjelent On an Island című albumának néhány dala is itt készült. Syd Barrett két 1970-es szólóalbumának (The Madcap Laughs, Barrett) munkálatai is itt folytak.

A Shadows Live at the Abbey Road című albumának borítója a Beatles-albumborító paródiája. A 2. stúdióban dolgozott még a The Hollies, Manfred Mann és a Gerry & The Pacemakers is.

A stúdióban dolgozó ismert producerek és hangmérnökök közé tartozik Sir George Martin, Geoff Emerick, Norman Smith, Ken Scott, Mike Stone, Alan Parsons, Phil McDonald, Richard Lush és az ADT feltalálója, Ken Townshend. A stúdió főhangmérnöke Chris "Vinyl" Blair volt, aki pályáját egyszerű magnókezelőként kezdte. Az évek során kitartó munkával a stúdió élére került. Karrierjének csúcspontja a Radiohead Kid A című albumáért kapott díj volt. Blair 2005. november 7-én halt meg.

Források

További információk
 Abbey Road Studios – Hivatalos oldal
 "Inside Abbey Road" - Virtuális interaktív séta sok információval a Google jóvoltából

Zenei stúdiók
London kulturális intézményei

redpajama_set_name: RedPajamaWikipedia


Winter is officially here, I think. I don't go by official dates, just months. So I'm here to share my Fall reading list, completed during September, October, and November. All books, except for a few written by my friends and some of the kids books I read, have been reviewed. You can read the reviews on my other blog, link in the sidebar.
I read a lot of books by my friend this month, and really enjoyed them.
A little kids book, the series is called Piggie and Elephant and everyone should read them. They are fun books.
One of Tolkien's books, which he wrote after one of his sons lost his toy dog. I love this book.
A true story. It was sometimes hard to read, because it showed the war through the eyes of a young girl.
Weird, but fun to read.
This had a very Roman feel to it, but I still ended up liking it. It is written by the Author of The False Prince, which I love.
One of Lemony Snicket's books for kids. A little creepy, but still good.
Another book by a friend. A fantasy. Which was amazing.
A Sherlock Holmes retelling of sorts. This series is wonderful, also Steampunk which is an added bonus.
A WWII story about three brothers who saved 1,200 Jews in Russia. The movie Defiance was based off their story.
Cinderella retelling by one of my favourite Authors.
This book. There are no words for how much I love this book.
Sequel to Vango...just as amazing.
A short book by one of my friends. It was enjoyable.
BABY JACE!!!!!!!!!! Baby Jace is adorable and heart breaking.
And that is my list. Smaller then I had intended, but I got to read some amazing books so that made up for it.
The King's Scrolls and Half-Blood! Two of my favorite books. Baby Jace is SO heartbreaking. And when Strune (you know, but spoilers), it was awful. Jaye is such an amazing author.
Wow! I wouldn't consider this a short list at all--more than I read, for sure!
Wow. I wouldn't consider that a short list, either. Impressive!
Well, I'm impressed!!! Sounds like you've gotten to do a ton of fun reading this Fall!
Nice list! I just read Vango because of your recommendation. I enjoyed it!
Every time I see "Red Rackham's Barnacles" it brings me back to The Big Fat Tintin Quiz... "That is in the movie! You've got one wrong. Now you've got to go cut off your quiff."


text:
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Happy Birthday, Albert Camus. Your life was a testament to courage. Your devotion to the cause of human rights continues to inspire us all. Thank you.
I like this quote, Rebecca. It made me think, do we, in fact, pursue that which first made us passionate, that which first made our heart open? What an interesting idea. I think there is a grain of truth to it.
I think there is too! In all the hustle and bustle of life, with all of the many expectations that are inherent in our social order, we somehow forget what makes our hearts joyful and our existence complete. Perhaps we think that to pursue our goals, that we are selfish. It is something to think on….
He was my literary hero, back in the day. I much preferred Camus to Sartre!
Thank you for those quotes. I think they capture the spiritual difference between the two.
I heard something on NPR about the rift between Camus and Sartre, and it seems to have related to loyalty to the Communist party. Sartre was convinced and Camus was skeptical. I'll go with the skeptic any day!
such a brilliant man! love the photo too!
He was indeed! Thank you so much for your heartwarming comments!!!
Thank you for this lovely tribute, dear Rebecca! He was a fine man indeed.


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NASAA: "Operation Cryptosweep" Announces 200 ICO Investigations Underway Now
August 29, 2018 @ 8:38 am By Cali Haan
200 active investigations into ICO (initial coin offering) fraud are presently being conducted across North America as part of "Operation Cryptosweep," the North American Securities Administrators Association (NASAA) announced yesterday.
Operation Cryptosweep, an investigative and enforcement action being coordinated by over 40 state and provincial regulators and law enforcement agencies across the US and Canada, began in May.
The NASAA says a total of 46 enforcement actions involving ICOs or cryptocurrency-related investment products have been initiated so far as part of the operation.
Over the past few years, initial coin offerings created much excitement as a way to generate fast capital and engage in speculative investing without having to fulfill the elaborate legal oligations of creating an IPO .
Possibly in order to skirt securities regulations, many ICO purveyors sold their investment products as "utility tokens" rather than securities, and claimed these tokens would one day give users access to important blockchain services.
Although most issuers insisted in public that the tokens were not securities, ICO "utility tokens" are typically moved onto dedicated exchanges for speculative trading as soon as possible.
Critics have questioned the idea of a "utility token" by arguing that it's absurd to ask customers to use an appreciable asset to purchase goods and services. "That's like buying products on Amazon using Amazon stock," said ICO critic and former Wall Street risk analyst Tone Vays.
Various researchers and pundits have claimed that between 67 and 81% of all ICOs have already failed. "Exit scams" are common, and scams reported on a daily basis in the global press.
In the early days of the investigation, the NASAA claimed it found over 30,000 online domains promoting cryptocurrency products, the vast majority of them new.
As of today, the Etherscan.io website shows that 114 000 Ethereum ERC 20 tokens (the most popular ICO format) have been created.
Ethereum was the first blockchain to popularize and enable the creation of ICO tokens. Several other platforms have since emerged that also offer the creation of ICOs.
Borg said that Operation Cryptosweep regulators have not only found instances of outright securities fraud, but, "are finding many other potential violations of state and provincial securities laws, including failure to properly register a product before it was offered to investors."
He emphasized the importance of compliance and responsibility among businesses interested in the new method of fundraise:
"While not every ICO or cryptocurrency-related investment is a fraud, it is important for individuals and firms selling these products to be mindful that they are not doing so in a vacuum; state and provincial laws or regulations may apply, especially securities laws. Sponsors of these products should seek the advice of knowledgeable legal counsel to ensure they do not run afoul of the law. Furthermore, a strong culture of compliance should be in place before, not after, these products are marketed to investors."
Borg also advised investors to be similarly circumspect:
"Be cautious when dealing with promoters who claim their ICO offering is exempt from securities registration but do not ask about your income, net worth or level of investing sophistication. Do your homework and contact your state or provincial securities regulator with any concerns before parting with your hard-earned money – afterwards may be too late."
When Operation Cryptosweep was announced in May, Tennessee Department of Commerce and Insurance Commissioner, Julie Mix McPeak, called cryptocurrency fraud, "a significant threat to Main Street investors in Tennessee."
https://www.crowdfundinsider.com/2018/05/133750-forty-north-american-regulators-cooperating-in-operation-cryptosweep-crackdown/
Joseph Rotunda, Director of the Enforcement Division of the Texas Securities Board and the Vice-Chair of the Enforcement Section for NASAA, said that, even in it's early stages, Operation Cryptosweep was confirming his suspicions:
"The market for cryptocurrency investments is saturated with widespread fraud."
See all Cryptosweep Actions below.
nasaa.org-Operation Cryptosweep
This entry was posted in Uncategorized and tagged joe borg, nasaa, operation cryptosweep. Bookmark the permalink.


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SOMETHING BORROWED | Advance Screening(s) Giveaway!
Texas, score passes to our advance screenings in Austin, Dallas, Houston & San Antonio!
By Dave Campbell | April 20, 2011
Smells Like Screen Spirit & Warner Bros. invite you
to RSVP for passes to our special advance screenings
on Monday, May 2, 2011 at 7:30 PM
in Austin, Dallas (Plano), Houston & San Antonio TX.
Synopsis: Rachel (Ginnifer Goodwin) is a talented attorney at a top New York law firm, a generous and loyal friend, and, unhappily, still single—as her engaged best friend Darcy (Kate Hudson) is constantly reminding her. But after celebrating her 30th birthday, perpetual good girl Rachel unexpectedly ends up in the arms of the guy she's had a crush on since law school, Dex (Colin Egglesfield)…who just happens to be Darcy's fiancé. As one thing leads to another in the frantic weeks leading up to Darcy's wedding, Rachel finds herself in an impossible situation, caught between her treasured friendship with Darcy and the love of her life. The romantic comedy "Something Borrowed" also stars John Krasinski as Ethan, Rachel's constant confidante and sometimes conscience, who is busy evading the affection of Darcy's hopelessly love-struck friend Claire (Ashley Williams) while harboring a secret crush of his own; and Steve Howey as the charming and irrepressible Marcus, whose designs on Rachel don't necessarily exclude any other woman who catches his eye.
Starring: Kate Hudson, Ginnifer Goodwin, John Krasinski, Colin Egglesfield, Steve Howey
Studio: Warner Bros.
Release Date: Friday, May 6, 2011
MPAA Rating: RATED PG-13 FOR SEXUAL CONTENT INCLUDING DIALOGUE AND SOME DRUG MATERIAL.
Screening Info: May 2, 2011 at 7:30 PM
AUSTIN RSVP
DALLAS (PLANO) RSVP
HOUSTON RSVP
SAN ANTONIO RSVP
Arrive early. Screenings are over-booked to ensure a full house and to compensate for "no shows." Tickets are not a guarantee of admission.
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