text:
Development of PEG-sheddable pH-sensitive liposomes for cytoplasmic drug delivery to pancreatic cancer
Kanamala, Manju
Degree Name: PhD
Degree Grantor: The University of Auckland
Background: Conventional chemotherapy is still the main stay treatment for cancer, but its efficacy is limited by its nonspecific drug distribution and lack of selectivity. Compared to small molecular anticancer drugs, liposomes have many advantages including high drug loading, prolonged circulation time and enhanced tumor accumulation via the enhanced permeation and retention (EPR) effect. To further improve their specificity, the design of liposomes has been refined to exploit the three main features of tumor microenvironment, i.e. low extracellular pH, 'leaky' vasculature and hypoxia. Because of their abilities to undergo acid triggered destabilization, PEGylated pH-sensitive liposomes (pPSL) have been investigated as an effective drug carrier to confer preferential pH-sensitive tumor-targeted drug delivery. However, PEGylation, required for long circulation, also brings with it the 'PEG dilemma', which sterically hinders cellular uptake and subsequent endosomal escape at the target. As a result, drug activity is inevitably reduced after PEG modification. To achieve successful drug delivery for effective treatment, crucial issues associated with the PEG dilemma must be addressed. Aim: The overall aim of this thesis is to investigate a dual pH-responsive strategy, which involves the design and development of a pSL modified with cleavable PEGylation to overcome the PEG dilemma. Gemcitabine, a first-line chemotherapeutic drug for pancreatic cancer, is used as the drug model, and long circulation, intracellular delivery, endosome escape and tumor biodistribution abilities of the drug-loaded liposomes are systemically investigated. Methods: First two pH-cleavable PEG polymers containing acid labile hydrazone bonds between long PEG chains (PEG2000) and lipid anchors, (CHEMS in Chapters 3 and 4 and DPPE in Chapter 5) were designed and synthesized. The polymer synthesis was carried out via the reductive amination of Schiff's base between the aromatic benzaldehyde group of PEG (PEGB) and amino group of hydrazide activated CHEMS / DPPE to form PEGB-Hz-CHEMS and PEGBHz- DPPE respectively. The structural characterization was performed by nuclear magnetic resonance spectroscopy (1H NMR) and mass spectrometric techniques. An isocratic highperformance liquid chromatographic (HPLC) method was developed to facilitate the characterisation of PEGB-Hz-CHEMS modified pPSL (CL-pPSL1). The composition of the mobile phase was optimised by a multiple linear regression model. Due to the lack of UVchromophore in the structure of DPPE, fluorescence spectroscopy was used for characterization and the development of PEGB-Hz-DPPE polymer modified liposomes (CL-pPSL2). An optimised pH-sensitive liposome system comprised of DOPE, DSPC, CHEMS and cholesterol (at a molar ratio of 4:2:2:2) with enhanced stability and pH-responsiveness was used based on our previous research. Thereafter, the cleavable PEG polymers were utilised to modify the surface of the pH-sensitive liposome membrane (pSL) using a post insertion technique with the aim of enhancing the intracellular delivery of the liposomes. The insertion efficiencies of the two cleavable polymers into liposomes at various concentrations (equivalent to 3, 5, and 10 mol% to lipids) were systematically investigated using the HPLC-UV method for CL-pPSL1 (see Chapter 3) and the Nile Red spectrometric method for CL-pPSL2 (see Chapter 5). Furthermore, the PEG conformation of the polymers (brush or mushroom) on the surface of the liposomes was determined and optimised to estimate their long-circulation property (see Chapter 3). Conventional pPSL coated with DSPE-PEG2000 were used as the control for both CL-pPSL (see Chapters 4 and 5). To increase gemcitabine loading (DL) and entrapment efficiency (EE), a small volume incubation method was used for drug loading. In vitro cell uptake and the endosomal escape abilities of the dual fluorescent labelled CL-pPSL in comparison to pPSL were observed using confocal laser scanning microscopy (CLSM). An investigation of the pathways of endosome escape was performed by the live cell imaging of lysotracker red labelled cells incubated with CL-pPSL2 and pPSL using CLSM (see Chapter 5). The HPLC method was used to measure the intracellular drug concentrations (Ci) of Mia PaCa- 2 cells following their exposure to free drug, pPSL and CL-pPSL1 for 2 h. The cytotoxicity of gemcitabine-loaded CL-pPSL1 and CL-pPSL2 was investigated in Mia PaCa-2 pancreatic cell lines using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. IC50 values were compared with pPSL and the free drug solution. The pharmacokinetics of CLpPSL1 and CL-pPSL2 with respect to pPSL and the free drug solution was studied in Sprague Dawley (SD) rats. With some successful tumor growth in animal models, Mia PaCa-2 pancreatic tumor-bearing CD-1 nude mice were used to investigate the biodistribution (n = 3) of CL-pPSL in comparison with pPSL and the free drug solution. Results and discussion: The PEGB-Hz-CHEMS conjugate was synthesized with a yield of 90% and the structure was confirmed by 1H NMR and mass spectrometry. An HPLC method for the simultaneous analysis of PEGB and PEGB-Hz-CHEMS was established using a multiple linear regression model. Retention times for both the analytes were found to be functions of mobile phase composition as represented by regression equations. The established HPLC method provided rapid analysis for both analytes in 15 min and was validated to be highly reproducible and reliable. Using this simultaneous HPLC assay, the pH-sensitive PEG detachment rate of PEGB-Hz-CHEMS was determined as 50% at pH 6.5, and 80% at pH 5.5 in 1 h, while it was found to be relatively stable at pH 7.4 with a half-life of 24 h. The stabilityindicating HPLC assay also revealed that at acidic pH, two degradation products, PEGB-HZ and PEGB were formed via the cleavage of the hydrazide and the hydrazone bond respectively. The presence of the hydrazide bond was found to enhance the pH-sensitivity of the polymer without affecting its stability at pH 7.4 (discussed in Chapter 3). Liposomes consisting of DOPE, DSPC, CHEMS and cholesterol (4:2:2:2) with desirable sizes (100-120 nm) were obtained. This formulation was then post-inserted with PEGB-Hz-CHEMS for CL-pPSL1 and DSPE-PEG2000 for pPSL using a post-insertion technique. The maximum insertion efficiency of the PEGB-Hz-CHEMS into the liposomes was achieved by incubating with a polymer solution equivalent to 5 mol% to total lipids for 24 h at 4 0C. The grafting densities of PEGB-Hz-CHEMS on the liposomes was determined as 1.7 mol% by HPLC, achieving the 'mushroom' conformation on the liposomal surface, which is essential for their long circulation in vivo. Chapter 4 discusses the development and complete characterisation of CL-pPSL1 compared to pPSL1. Drug-loaded polymer-coated liposomes with an average size of 135-140 nm showed accelerated pH-triggered drug release at endosomal pH 5.0 compared to pPSL. Nevertheless, the results of the endosome escape study on Mia PaCa-2 cells suggested that the PEGylation of pPSL significantly decreased their endosome escape, with CL-pPSL1 achieving substantially enhanced calcein release to cytosol compared to pPSL. This correlated with cell uptake results, where CL-pPSL1 showed a 2-fold enhanced intracellular concentration compared to pPSL (P < 0.01). MTT cytotoxicity assays revealed that gemcitabine containing CL-pPSL1 showed a significantly higher cell killing effect compared to that of pPSL (52.4 nM vs 79.5 nM, P ≤ 0.05). In SD rats, the plasma pharmacokinetics study revealed that the clearance of both pPSL and CL-pPSL1 were 7 times slower compared to free gemcitabine, indicating their better long circulation abilities. However, at 12 h post intravenous injection, the gemcitabine-loaded CLpPSL1 resulted in a 2.5 times lower plasma concentration and 1.7 times lower AUC than pPSL, and simultaneously a 3-times higher liver accumulation compared to pPSL. This could be due to the poor insertion efficiency of the PEGB-Hz-CHEMS polymer, resulting in a lower degree of PEGylation (1.7% vs 5% of pPSL), leading to their more rapid clearance by the host reticuloendothelial system. The reduced insertion efficiency into the liposomes was due to the shorter lipid chain of the CHEMS, and therefore a lower critical micellar concentration of the polymer, which facilitated the majority of the polymer to exist as micelles. To overcome the issues encountered with the CL-pPSL1 polymer, we synthesized a second pHsensitive PEG polymer, PEGB-Hz-DPPE, by replacing the lipid anchor CHEMS with DPPE, a phospholipid (see Chapter 5). PEGB-Hz-DPPE was synthesized and confirmed by 1H NMR spectroscopy. pH-dependent degradation studies of polymeric micelles using DLS showed that, after 2 h of incubation, polymeric micelles at pH 5.0 displayed a rapid increase in particle size compared with pH 7.4. By monitoring the color of the supernatant post incubation of the liposomes with Nile Red labelled micelles, the insertion efficiency of polymeric micelles of PEGB-Hz-DPPE into the liposomes was found to be > 95%. In addition, CL-pPSL2 showed a rapid pH-triggered gemcitabine release compared to pPSL. In Mia PaCa-2 cells, the CL-pPSL2 showed rapid cellular uptake and endosome escape abilities, compared to pPSL. Interestingly, live cell imaging results clearly showed a fusion mechanism of endosome escape for CL-pPSL, and that CL-pPSL2 could rapidly escape into cytoplasm compared to pPSL. The plasma pharmacokinetics study revealed that free gemcitabine cleared 7-times faster compared with both CL-pPSL2 and pPSL. No significant difference in Vd, CL or the terminal T1/2 was observed between CL-pPSL2 and pPSL, indicating that cleavable PEGylation did not influenced the long circulation of CL-pPSL2. Because of its dual pHresponsiveness, increased cell uptake, rapid endosome escape and higher intracellular drug delivery abilities, CL-pPSL2 showed higher accumulation in tumors compared to pPSL (1.5- times) and the free drug solution (6-times), suggesting its potential for improved therapeutic efficacy. Conclusion: Dual pH-responsive liposomal tumor targeting successfully improved the cytotoxicity of gemcitabine in cancer cells by enhancing intracellular cytoplasmic delivery, due to its rapid pH-sensitive PEG detachment and endosomal escape abilities. Furthermore, the drug-loaded CL-pPSL2 was able to improve the tumor distribution of gemcitabine without compromising its stealth properties. In fact, for the first time, a dual pH-responsive strategy was reported with long circulation and pH-responsive tumor targeting abilities. However, future anti-tumor studies are still required to confirm if the enhanced tumor targeting abilities of these cleavable liposomes can result in greater therapeutic potential.
Name: whole.pdf
Doctoral Theses [6155]


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Provisional-ballot results are expected in Middlesex County
Updated: Apr. 02, 2019, 5:39 a.m. | Published: Nov. 14, 2008, 12:35 p.m.
By Diane C. Walsh
Middlesex County election officials are expected today to release the results from 6,474 provisional ballots cast in last week's election to help decid e council races in Metuchen, Milltown and Sayreville.
For the past 10 days workers at board of election workers have been researching the eligibility of the ballots. Provisional ballots are used when there is a question over whether a voter is registered when he or she goes to the polls.Jim Vokral, administrator of the county board of elections, said usually 30 to 40 percent of the provisionals are voided because the research finds they are not eligible voters.
There were 341 provisional ballots in Sayreville, where just 200 votes separated the winners and the losers. Vokral said 70 provisional ballots were cast in Metuchen, where the margin of victory is only 25 votes. Similarly, in Milltown there are 37 provisional ballots and only a 20-vote difference between the second, third and fourth place candidates for two seats.
Vokral expects to complete the count of provisionals by noon and County Clerk Elaine Flynn will announce the results.

redpajama_set_name: RedPajamaCommonCrawl


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text:
Din Tai Fung: Meet some of the people willing to wait hours in line for dumplings
By Sarah Fritsche on May 11, 2016 at 12:34 PM
Photo: Sarah Fritsche
Image 1of/9
Security guards and mall staff supervise the crowds gathering for Din Tai Fung's grand opening.
The front of the line for Din Tai Fung.
The line extended back hundreds of feet.
The end of the line. Mind you, this wasn't the line to be seated, this was the line to leave your name and number to be texted at a later point.
Dumpling makers hard at work trying to keep up with demand.
Dumpling production is showcased at the entrance of Din Tai Fung, giving hungry diners a peek at what is in store (once they're able to get a seat).
The first batch of lucky diners to get into Din Tai Fung. The people in this first seating began lining up a little after 9 a.m.
Another angle of the dining room and bar area.
The back dining room at Din Tai Fung.
Din Tai Fung: Long lines mark opening day of the popular dumpling palace
Be excited: the opening for Din Tai Fung is getting very, very close [UPDATE]
Din Tai Fung confirms its first Bay Area restaurant
Our coverage of the Bay Area's very first outpost of Taiwanese dumpling chain Din Tai Fung continues.
As promised, the lines for Tuesday's grand opening in Santa Clara's Westfield Valley Fair were epic.
On-hand to oversee the opening were members of Din Tai Fung's Southern California contingent, including Frank Yang — son of Bingyi Yang, who started Din Tai Fung in Taiwan back in the late 1950s — and his son, Albert Yang (see video below). Over the past fifty-plus years, the company has evolved from its early days as a peanut oil retailer to one of the most beloved dumpling houses in the world, so it's no surprise that people were willing to wait for hours to get a taste of xiao long bao.
On Tuesday, Inside Scoop talked to some of the folks who came out for opening day:
"This is my favorite restaurant in the world," said Angie Hicks. The Los Gatos resident, who often travels to Taipei — home of the original Din Tai Fung — was the tenth person in line when she arrived at the mall at 9:15 a.m. on Tuesday. According to Hicks, by 10 a.m., there were about 300-400 people waiting in line.
Once seated, Hicks ordered the pork dumplings and fried rice with pork chop — two of her favorite dishes — as well as the sesame dumplings for dessert. Hicks said she planned to take her leftovers back to her office since her colleagues hadn't been able to join her. (Hopefully they appreciated her efforts.)
Jin Yeo, who works in Santa Clara, said that she decided to come to the opening after seeing that someone had posted on Facebook that the restaurant was finally opening. Originally from Korea, where Din Tai Fung also has several locations, she said that yesterday was the first time she'd ever tried to eat at the chain. Why wait until now? The lines in Korea were too long, she said.
Originally from Taiwan, Charles, who preferred not to give his last name, said he was at the grand opening because his son, who was in school, had asked him to wait in line. He arrived around 10:30 to put his name in, and at around 1 p.m., when we spoke with Charles, he estimated that by the time his son was out of school, they would only have about another half-hour to wait. When asked about the long wait times, Charles thought it was fine, especially since it was the restaurant's first day. He even went so far as to describe it as fun. (Charles truly must have the patience of a saint.)
Don't expect the crowds to go away anytime soon. According to the Din Tai Fung team, expect the waits to continue to be between three to five hours for the next month.
Here are a few tips to keep in mind if you decide to brave the crowds. And, once again, if you do go, let us know about your experience in the comments below.
Din Tai Fung at Westfield Valley Fair, 2855 Stevens Creek Blvd., Space 1259, Santa Clara. (408) 248-1688. dintaifungusa.com


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Music > Vinyl > Primal Scream - Chaosmosis (Vinyl LP)
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Primal Scream - Chaosmosis
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Primal Scream Chaosmosis on LP
Formed in 1984 by Jesus & Mary Chain drummer Bobby Gillespie, Primal Scream released a pair of albums - Sonic Flower Groove (1987) and Primal Scream (1989) - before the group's landmark opus Screamadelica took home the first-ever Mercury Music Prize in 1991 and profoundly shaped the UK's pop musical landscape for more than a decade with its hallucinatory blend of dance, dub, techno, acid house and rock. Seven albums and almost 25 years later the band returns with Chaosmosis, their first since 2013's More Light. Recorded in London, New York and Stockholm, and written/produced by Gillespie and Andrew Innes, Chaosmosis is the freshest sounding album the band have ever made. The exhilarating first single, "Where The Light Gets In" features a duet with Sky Ferreira. Other guests include Haim on backing vocals and Rachel Zeffira from Cat's Eyes.
1. Trippin' on Your Love
2. (Feeling Like A) Demon Again
3. I Can Change
4. 100% or Nothing
5. Private Wars
6. Where the Light Gets In
7. When the Blackout Meets the Fallout
8. Carnival of Fools
9. Golden Rope
10. Autumn in Paradise


text:
When in 2009 I published a book called The Real Global Warming Disaster it provoked contrasting responses from two members of the royal family. Prince Charles, protesting that he was 'bemused' by my views on climate change, struck me off his Christmas card list, where I had been for 25 years since we became environmental allies back in the 1980s. I was, however, startled and delighted to have a long, thoughtful and sympathetic letter about the book from Prince Philip, whom I had met only once, and which, inter alia, led me to be far from surprised when he last year made headlines for having dismissed wind turbines as 'absolutely useless'. Back in the 1960s, now to my shame, I once wrote a far from kindly profile of Prince Philip in Private Eye. Over the decades since, like many others, I have come to have ever more admiration for him, not least since he represents those values of robust masculine common sense which in the post-war years when I grew up were taken for granted, but which in our public life are today little more than a memory, Last year one newspaper marked his 90th birthday by publishing a list of his 'notorious gaffes'. Since then I have met several people who, like me, went through that list ticking off every one of his supposedly embarrassing comments with a nod of amused approval. How fortunate we are to have had such a man at the centre of our national life for 65 years.
One of the best-kept secrets of British journalism, because it is scarcely in the interests of newspapers to report it, is the alarming speed at which their readership has been collapsing. When the monthly circulation figures appear, my first instinct is always to look at those for the two newspapers with which I have been most associated — the Sunday Telegraph now down to 458,487, having lost 9 per cent of its sales in the past year (seven years ago it was three quarters of a million), the Daily Telegraph down to 581,249 (when once it stood at over a million). But even these losses pale beside those of many other titles — the Financial Times in the past year has lost nearly 14 per cent, the Observer 15 per cent, the Guardian 16 per cent, the Mail on Sunday 21 per cent, the Sunday Express 22 per cent, the Independent on Sunday 30 per cent and the Sunday Mirror nearly 40 per cent. Admittedly there are special factors here, such as the fleeting boost given to Sunday tabloids by the News of the World's closure, but the general impression that newspapers are a dying industry is unmistakable. Different reasons might be given for this, some more trenchant than others, but certainly these losses are not being made up by any corresponding gain in revenue from
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London Paris New York those who now read their newspapers online. It seemed quixotic of the New York Times to headhunt the BBC's directorgeneral Mark Thompson as its new chief executive on the grounds that he had helped to build the BBC's website into one of the world's most-read. One doubts whether chucking millions of licence payers' pounds at the BBC website is a trick the paper could afford to repeat.
What the New York Times also clearly hadn't registered about the BBC is that, under Mr Thompson's direction, its journalism has become more than ever a national embarrassment. It's not just that on a whole range of issues, from climate change to the economy, it has become so childishly biased (when has its journalists' obsession with 'wicked bankers' and 'cuts' allowed them to tell us that the government now borrows a record £4 billion a week to finance its spending deficit?). Any vestige of professional standards has gone out of the window. So blinkered have they become that they have lately completely missed by far the most important story of the moment: the debate raging in Germany as that country finally loses patience with the idea that it should be expected any longer to bail out the doomed euro. We may recall economics editor Stephanie Flanders some time back pouring scorn on all those predicting that the euro would 'crash and burn', as she proclaimed its future was 'secure'. When its collapse dominates the front pages this autumn, will she even notice?
In our record-breakingly wet summer, I have seen fewer butterflies than I can remember in all the 68 years I have been observing these stunningly colourful insects. But on a hot afternoon this week I was delighted to see 20 peacocks and small tortoiseshells on just one buddleia in our Somerset orchard, all having suddenly emerged in perfect condition. Long gone may be those clouds of butterflies familiar in my youth, but such miraculous powers of survival can still give us cause for astonished pleasure.
Christopher Booker is a columnist for the Sunday Telegraph.
the spectator | 25 august 2012 | www.spectator.co.uk
Spectator125x59mm.indd 1


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Wayne Richard Presley (born March 23, 1965) is an American former professional ice hockey right winger who played 12 seasons in the National Hockey League from 1984–85 until 1995–96.

Biography
Presley was born in Dearborn, Michigan and raised in Taylor, Michigan. As a youth, he played in the 1978 Quebec International Pee-Wee Hockey Tournament with a minor ice hockey team from Detroit.

Presley was drafted 39th by the Chicago Black Hawks in the 1983 NHL Entry Draft. His best statistical season was the 1986–87 NHL season, when he scored 32 goals and 61 points. He also scored five shorthanded goals in consecutive years, 1993–94 and 1994–95. He played 684 career NHL games, scoring 155 goals and 147 assists for 302 points.

Presley also represented the United States at the 1987 Canada Cup.

Career statistics

Regular season and playoffs

International

References

External links

1965 births
Living people
American men's ice hockey right wingers
Buffalo Sabres players
Chicago Blackhawks draft picks
Chicago Blackhawks players
Ice hockey players from Michigan
Kitchener Rangers players
New York Rangers players
People from Taylor, Michigan
San Jose Sharks players
Sault Ste. Marie Greyhounds players
Sportspeople from Dearborn, Michigan
Sportspeople from Wheaton, Illinois
Toronto Maple Leafs players

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Hello. I try to download the driver P1102w in the hp website. It is "hp_LJP1100_P1560_P1600_Full_Solution-v20120831-50157036_SMO1". However after I download and unzip, it appears nothing after 100% unzip success. Usually shouldn't the installation process begins? But it didnt: Please help me to check if the driver is outdated. Thanks.
Double click HpSetup.exe and the setup will begin.
Thanks. The problem solved! Finally I discover it is the window's own problem. I install zip programme the exe can be extracted finally.


The fund requested will be used to set a location in about two countries in Africa and one in U.S.A. The investor would have a company share of 50%.
Our company deals with development of websites, creation of computer software and new computer generations. In this project, we will be offering web services (Web development) as well as software and hardware services (creation of computer software and creation of new computer generations). We will be designing Websites as well as maintaining them for our customers. We will also be creating computer software and new generations of computers and laptops for people around the world.
We are already registered as a privately-held limited liability company in the Republic of Ghana.
We are targeting the international market because that is where our products will be selling well and we will also get profit on that. To find out more about our products and services, please refer to the file attached.
After closed calculations and verification, we concluded that we can make $2151.09 within a month therefore $280409.73 within a year at a good level of productivity.
We have not been able to make much so far because we do not have enough funds to launch the business but with a good help, we would like to start this project on the 10th of August, 2012. For that we need $300000.00 to start up the business and so far we have none invested.
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text:
Home / news / Despite US sanctions, Moscow and Ankara affirm the continuation of their military cooperation
Despite US sanctions, Moscow and Ankara affirm the continuation of their military cooperation
Russian Foreign Minister Sergey Lavrov said that the Russian-Turkish military cooperation will continue despite US sanctions, while his Turkish counterpart, Mevlüt Çavuşo العلاقاتlu, confirmed that relations with Moscow are not a substitute for its relationship with NATO, Europe and America.
At a press conference with his Turkish counterpart, after their talks in the Russian city of Sochi, Lavrov stressed that the relations between Moscow and Ankara are based on the common interests of the two countries. "We affirmed our common determination to develop our technical and military cooperation," he added.
The Russian minister affirmed that President Vladimir Putin appreciates Turkey's determination to "continue cooperation in this field despite the illegal pressures on Washington."
For his part, Turkish Foreign Minister Mevlut Cavusoglu said that Turkey's relations with Russia are not an alternative to its relations with NATO, Europe or the United States.
Cavusoglu stressed that Ankara attaches great importance to these relations, stressing that the sanctions imposed on Turkey will not push it to abandon its positions.
The United States imposed sanctions on Turkey over its purchase of the Russian "S-400" missile defense system (S-400), and the European Union's preparation of punitive measures due to Turkey's dispute with Greece and Cyprus over rights in the Mediterranean waters.
Washington prohibited granting any arms export permits to the Turkish government administration to purchase weapons, and the head of this administration and other officials were prevented from entering the US.
Turkish President Recep Tayyip Erdogan condemned these sanctions, saying that they "infringe" on the "sovereignty" of his country.
In the same context, Lavrov said that Russia and Turkey have agreed to continue joint work to normalize the situation in Libya.
Lavrov clarified that the two sides agreed to continue fully contributing to the normalization of the situation in Libya through comprehensive dialogue between all the main political forces in Libya.
The Turkish Foreign Minister also stressed that no one can ask Turkey to leave Libya, because there is an agreement between Ankara and the legitimate authorities in Libya.
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5 trends that will define America during the year 2021


text:
ACCESS formed in 2018 as an evolution from AUSCCER: the Australian Centre for Cultural Environmental Research. ACCESS builds on AUSCCER's tradition of research excellence and innovation, as well as its commitment to collegial and collaborative research practices. AUSCCER was founded in 2009 around human geographers' culturally-inflected work on socio-environmental relations. ARC Laureate and Future Fellowship funding from lead researchers Prof Lesley Head and Prof Chris Gibson, combined with UOW support, saw AUSCCER attain the status of a UOW Research Strength. Since then, growing from a series of externally funded research projects (including a groundbreaking longitudinal study of household sustainability practices led by Prof Gordon Waitt), the Centre had grown, attracting talented new staff and a growing cohort of top quality HDR students. Bound by a collective interest in critical and generative research for progressive social and environmental change, qualitative methodologies and a valuing of diverse knowledges, the group's research interests have expanded. Reflecting this expansion in size and in the scope of research, the group entered a new chapter; renamed in 2018 as ACCESS—Australian Centre for Culture, Environment, Society and Space—under the Directorship of Prof Pauline McGuirk.
One thought on "About ACCESS"
shanthni balu on May 20, 2014 at 1:16 am said:
I would like to get details of pursuing PHD at your university


text:
package com.vaadin.elements.common.js;

import java.util.List;

import com.google.gwt.core.client.JavaScriptObject;

/**
 * Class with static utilities for @JsType
 *
 * TODO: revisit when JsInterop supports static or default methods in @JsType
 * interfaces
 *
 */
public abstract class JS {

    private static final String NAMESPACE_VAADIN = "vaadin.elements";
    public static final String NAMESPACE_API = NAMESPACE_VAADIN + "._api";
    public static final String NAMESPACE_GRID = NAMESPACE_VAADIN + ".grid";

    @SuppressWarnings("unchecked")
    public static <T> T createJsObject() {
        return (T) JavaScriptObject.createObject();
    }

    @SuppressWarnings("unchecked")
    public static <T> T createJsArray() {
        return (T) JavaScriptObject.createArray();
    }

    public static <T> JSArray<T> createArray() {
        return createJsArray();
    }

    /**
     * Box a native JS array in a Java List. It does not have any performance
     * penalty because we directly change the native array of super ArrayList
     * implementation.
     */
    public static native <T> List<T> asList(JavaScriptObject o)
    /*-{
        var l = @java.util.ArrayList::new()();
        l.@java.util.ArrayList::array = o;
        return l;
    }-*/;

    public static native boolean isPrimitiveType(Object dataItem)
    /*-{
        return Object(dataItem) !== dataItem;
    }-*/;

    /**
     * Promote a plain JSO to a GWT java class.
     */
    public static native <T> T promoteTo(Object o, Class<?> clz)
    /*-{
        var p = @java.lang.Class::getPrototypeForClass(*)(clz);
        if (o.__proto__ && o.__proto__ !== p) {
            o.__proto__ = p;
            o.__reassignPending = true;
        }
        return o;
    }-*/;

    /**
     * Loop over an object properties and call customized setters which are present in its prototype.
     * Useful after promoting a JSO to Java and make old values effective.
     */
    public static native void reassignProperties(Object o)
    /*-{
        if (o.__reassignPending) {
            delete o.__reassignPending;
            var p = o.__proto__;
            for (var i in o) if (o.hasOwnProperty(i) && p.hasOwnProperty(i)) {
                var v = o[i];
                delete o[i];
                o[i] = v;
            }
        }
    }-*/;

    public static native boolean isUndefinedOrNull(Object o)
    /*-{
      return o === undefined || o === null;
    }-*/;

    public static native boolean isObject(Object o)
    /*-{
      return typeof o === "object" && o !== null;
    }-*/;

    public static native JavaScriptObject getError(String msg)
    /*-{
        return new Error(msg || '');
    }-*/;

    public static native JavaScriptObject getUndefined()
    /*-{
        return undefined;
    }-*/;
}

redpajama_set_name: RedPajamaGithub


Oklahoma Attorney General Scott Pruitt may be a climate change denier, but that alone won't derail his nomination to lead the Environmental Protection Agency. So when confirmation hearings for President-elect Donald Trump's controversial pick begin on January 18, you can expect to hear a lot about mercury. It's part of a larger strategy by Senate Democrats to frame his nomination as the culmination of a cynical, years-long attack on science and reason whose purpose was to protect the interests of the fossil fuel industry—and his own.
Opposing mercury pollution is a no-brainer. Its harms include serious damage to the nervous, pulmonary, digestive, and immune systems and developmental brain defects. In 2011, after years of study, the EPA limited how much mercury oil-fired and coal-fired power plants can emit. The agency's Mercury and Toxic Air Standards (MATS) will save thousands of lives and prevent an estimated 11,000 premature births a year. Great, right? Not according to Pruitt, who joined more than 20 states in suing to block the rule—an appeal that was ultimately declined by the Supreme Court last summer, leaving the rule in place.
For Senator Tom Carper of Delaware, the Democrats' ranking member on the Senate Environment and Public Works (EPW) Committee, mercury is a great example of why Pruitt should not head the EPA.
"Scott Pruitt's views are so far out of the mainstream that confirming him as the head of the EPA would be a mistake," Carper told the New Republic. To vet Pruitt's extreme views, he and committee Chairman John Barrasso, a Republican from Wyoming, have discussed holding longer-than-usual hearings for the nominee—one to two days as opposed to the half-day that is customary for cabinet-level appointments. Carper is also planning on bringing in an outside expert panel to focus, in part, on mercury.
For Senate Democrats, who insist the confirmation is not a foregone conclusion, the hearings are a chance to show that Pruitt is a prosecutor with an inherent conflict of interest with the EPA's mission to defend human health and the environment. According to Senator Brian Schatz of Hawaii, Pruitt would be a "historical outlier" among both Republican and Democrat EPA administrators, who would shred rather than faithfully administer the Clean Air and Clean Water Acts.
Democrats could frame a Senate vote for Pruitt as a vote for corrupt special interests and against science.
Pruitt has sued the EPA fourteen times, with at least eight active lawsuits against the agency, and has deep financial ties to fossil fuel companies that would win big if the suits were ruled in their favor. Democrats could frame a Senate vote for Pruitt as a vote for corrupt special interests and against science.
Republicans say the claim is nonsense. Senator Shelley Moore Capito, a Republican from West Virginia, pointed to mercury as an example of why Pruitt is "an ideal candidate to look at the real-world consequences of the agency's regulatory actions." Capito portrayed MATS as an illegal, Congress-bypassing rule that cost crucial jobs in her state, part of what she claimed was an intentional effort by President Barack Obama to undermine the coal industry.
Carper compared the notion to hiring the mastermind behind Russian cyber-attacks against the U.S. to head U.S. cyber-security.
Still, it's clear Senate Democrats cannot confine themselves to mercury's harms alone. Instead, they must show a gaping chasm between Pruitt's motives and the EPA's mandate, which rests on the idea that when enough scientific evidence of a harm exists, the federal government must act quickly to avert it, economic costs and regulatory hassles for fossil fuel interests aside.
To do so, Senate Democrats will attempt to trace a trail of "dark money" between energy companies and Pruitt as he waged legal war on Obama's EPA.
In a letter sent in December, five committee Democrats and Senator Bernie Sanders grilled Pruitt on his connection to Oklahoma oil and gas giant Devon Energy, whose talking points Pruitt parroted in a letter to the EPA. This revelation was part of a 2014 New York Times investigation that found links between Republican attorneys general and energy companies, which gave $16 million to their campaigns. The senators also demanded that Pruitt reveal all the anonymous donors behind the Rule of Law Defense Fund, a 501(c)(4) group he helped create and is linked to the Republican Attorneys General Association. Supported by Freedom Partners, which funds causes championed by the Koch brothers, the Fund has worked to combat various Democratic initiatives, from instituting overtime laws to implementing the EPA's Clean Power Plan.
In another letter, Carper questioned Pruitt about his ties to two super PACs funded by fossil fuel interests that, at the time of his EPA nomination, were staffed by key personnel from his 2014 reelection campaign.
"We should not have a fossil fuel puppet in the office directing the EPA," said Senator Jeff Merkley, a Democrat from Oregon.
Pruitt has since stepped down as chairman of the Rule of Law Defense Fund and closed down the PACs, presumably to address these concerns, but Senate Democrats will likely pursue these ties—particularly since a new secretive PAC was recently created to protect Pruitt's appointment from "anti-business, anti-environmental extremists," E&E News and Politico reported.
"The question of the financial entanglements between Mr. Pruitt and the fossil fuel industry is a very critical element of exploring the conflict of interest that his candidacy likely represents," said Democratic Senator Sheldon Whitehouse of Rhode Island, who is on the committee.
Democratic senators also said they will be questioning Pruitt on his beliefs on human-caused climate change. Pruitt has been widely described as a climate change denier, partly based on an op-ed he co-wrote with Alabama Attorney General Lester Strange in which he described the science of climate change as "far from settled" and the subject of "debate." Former Florida Governor Jeb Bush, defending him from the charge, wrote that Pruitt "supports a robust discussion" about climate change.
"If you are to head up the agency that is sworn to head up the effort to reduce morbidity and protect human welfare, there is no responsible action other than taking strong steps to control climate change at its source," Holt added.
Instead, Pruitt joined 26 states in challenging the EPA's greenhouse gas–cutting Clean Power Plan, which is the United States's main (and potentially only) way to reach its goals outlined by the 2015 Paris Climate Agreement. Trump has promised to destroy the plan, which is currently held up in courts.
Seen through this lens, climate change is a hysteria-fueled excuse for federal government overreach that threatens good fossil fuel jobs based on a global conspiracy of climate scientists—an unlikely message that has been extremely powerful.
Only a handful of Senate Republicans have strayed from this public position. During a 2015 debate over the Keystone XL pipeline, climate hawk Schatz introduced an amendment declaring that humans contributed significantly to climate change. Every Democrat voted yay, along with just five Republicans, three of whom remain in the Senate: Susan Collins of Maine, Lamar Alexander of Tennessee, and Lindsey Graham of South Carolina.
To block Pruitt's nomination, the Democrats need to find four votes from Republicans, since Democratic Senator Joe Manchin, up for reelection in the coal state of West Virginia in 2018, has announced he's for Pruitt. Collins, Alexander, and Graham have not publicly stated how they will vote. So Senate Democrats, while targeting Pruitt's views on climate change, are not staking the vote on that alone.


yippee! i love lmnop! go download the newest copy today. lots of goodies galore just in time for the holidays! their gift guide was filled with must haves as were their selection of adorable swimwear - makes me wish it was summer again already!
i loved the animal index at the start to use as placeholders on a bookshelf! so cute and i bet they would be so easy to make at home as well.
so take a quick break from the kids and go take a stroll through lmnop and let me know what you loved about the issue. what's your fave gift item shown?


Flags used in Fishing, often called "Capture Flags" are the glad rags of fishing. Raise a capture flag on your boat and it is a public announcement of your catch. Using our Sundot Marine Flags denotes the species of fish you catch (or catch and release) and signals success to other boats, anglers and even spectators in the harbor.


Dedicating to the research and innovation in magnetics and power supply & providing the world-class customer with the optimal system solution.
Advanced manufacturing equipment, flexible production process, and TPM facilitates enterprise development.
Have the leading-edge technology to strengthen the core competence of sustaining operation, enterprise transformation and technology upgrading.
Advanced corporate culture is the most important guarantee for the sustainable development.
? 2013 COPYRIGHT Shenzhen JingQuanHua Electronics Co., Ltd.


text:
Q: Adyen web service access with .Net I am trying to implement Adyen recurring payment to my web application (C# .Net 4) but being relatively new to web services I am not sure I am doing it the right way.
In short the payment provider exposes a WSDL url for that purpose (https://pal-test.adyen.com/pal/Recurring.wsdl) and I added it in Visual Studio 2010 as a Service Reference (i.e. Add Service Reference > Advanced > Add Web Reference)
I then went on and created a test page, to make sure the connection was operational (see code below) and retrieve the details of a test subscription that I created previously. However I am getting an exception when executing the 'listRecurringDetails' action with the error message is 'Object reference not set to an instance of an object." and I cannot figure where I am going wrong.
Any feedback would be welcome.

#

public partial class Store_ServiceTest : System.Web.UI.Page
{
    protected void Page_Load(object sender, EventArgs e)
    {
        Recurring proxy = new Recurring();
        ICredentials usrCreds = new NetworkCredential("[username]", "[password]");
        proxy.Credentials = usrCreds;

        try
        {
            RecurringDetailsRequest thisUserDetail = new RecurringDetailsRequest();
            thisUserDetail.merchantAccount = "[some reference]";
            thisUserDetail.shopperReference = "[some reference]";
            thisUserDetail.recurring.contract = "RECURRING";

            RecurringDetailsResult recContractDetails = proxy.listRecurringDetails(thisUserDetail);
            string createDate = recContractDetails.creationDate.ToString();
        }
        catch (Exception ex)
        {
            string err = ex.Message;
        }
        finally
        {
            proxy.Dispose();
        }
    }
}

Call Stack

App_Web_4h0noljo.dll!Store_ServiceTest.Page_Load(object sender, System.EventArgs e) Line 38    C#

Output window

A first chance exception of type 'System.Threading.ThreadAbortException' occurred in mscorlib.dll
An exception of type 'System.Threading.ThreadAbortException' occurred in mscorlib.dll but was not handled in user code
A first chance exception of type 'System.NullReferenceException' occurred in App_Web_4h0noljo.dll
The thread '' (0x15d0) has exited with code 0 (0x0).

A: Your code looks good. The key is to add the Recurring service as a
Service Reference instead of as a Web Reference. It should work if the
app configuration file contains:
<system.serviceModel>
 <bindings>
     <basicHttpBinding>
         <binding name="AdyenHttpBinding">
           <security mode="Transport">
             <message clientCredentialType="UserName"/>
             <transport clientCredentialType="Basic" realm="Adyen PAL Service Authentication"> <!--Adyen PAL Service Authentication-->
               <extendedProtectionPolicy policyEnforcement="Never"/>
             </transport>
           </security>
         </binding>
     </basicHttpBinding>
 </bindings>
 <client>
   <endpoint address="https://pal-test.adyen.com/pal/servlet/soap/Payment" binding="basicHttpBinding" bindingConfiguration="AdyenHttpBinding" contract="Adyen.Payment.PaymentPortType" name="PaymentHttpPort"/>
   <endpoint address="https://pal-test.adyen.com/pal/servlet/soap/Recurring" binding="basicHttpBinding" bindingConfiguration="AdyenHttpBinding" contract="Adyen.Recurring.RecurringPortType" name="RecurringHttpPort"/>
 </client>
</system.serviceModel>

Kind Regards,
Sander Rasker (Adyen)

redpajama_set_name: RedPajamaStackExchange


text:
Sweden Stage
Ok, so the rating above might have given away my review here, but if there is one perfect festival act, it has to be the Quireboys. Sure, only lead singer Spike and guitarist Guy Griffin remains from the original line-up, but this line-up sure knows how to handle good time rock 'n' roll in the vein of The Rolling Stones and The Faces. Besides, guitar player Paul Guerin has been with the band for 11 years now, so he almost counts as an original member. Well, he's very important for the Quireboys' sound, at least. I can't think of a better way to start the festival than grooving along with Spike and his band in the evening sun with a beer in my hand. The band kicked off their set with a newie, "Too Much Of A Good Thing" from their 2013 Beautiful Curse album. It might not be one of their most recognizable songs, but the groove and swing is impossible to not surrender to – the Quireboys had won by the first chord. When that one went straight into "There She Goes Again" from their debut album A Bit Of What You Fancy (1990), nothing could stop this well oiled (sic!) groove machine from kicking our butts big time. "This Is Rock 'n' Roll", the title track from their 2001 comeback album, has turned into a "modern" Quireboys classic and by the looks of the audience, everybody owns that album. "Mona Lisa Smiled" might be something of a ballad-type of song on their album Homewreckers & Heartbreakers from 2008, but live it turns into a groove monster deluxe and the striking melody makes us sing along with big smiles on our faces – what a fantastic song it is, easily one of their best and no Quireboys-gig is complete without it. "Whippin' Boy" is a slow blues track, but it doesn't set anything at halt at all, we groove along with the band on this darker piece and I wouldn't want to be without it. "I Don't Love You Anymore" is probably the Quireboys biggest hit ever. The 1990 ballad was all over the place back when, but it has nothing to do what so ever with all the Bon Jovi / Europe type of power ballads that was around then – this is a ROCK ballad and boy, Spike & co. even manage to make a ballad swing. Do I have to mention that we all sang our throats sore? The Bob Rock produced Bittersweet And Twisted from 1993 might have a reputation for being the band's big flop, but in reality, the album was about to follow up a masterpiece and that can only go one way. It's an overlooked album that deserved a better destiny and therefore it's great that the guys at least play one song off that record. Tonight's choice was "Tramps And Thieves" and it worked like a charm – killer track. But it would be a lie to try to say anything else than it's the songs from the debut that goes down the best, especially the hits. "Hey You" lifts the roof off Sweden Rock, of course. Yes, I know it's an outdoor festival, but you get the idea – if there ever was a party track, that has to be it. A happy surprise is that the following song "Beautiful Curse" almost gets the same treatment from the crowd. I'm starting to believe that the newer Quireboys-records has found a home at many fans' houses. "Sweet Mary Anne" is written for the stage and when the song burst into action after a slow intro, the whole crowd goes wild. "I Love This Dirty Town", also from Homewreckers & Heartbreakers, has a heavy groove that really should work like a charm live, but for some reason it doesn't kick as much ass as I had thought. But that didn't matter because the ending with the band's trademark "7 O'Clock" and encore "Sex Party" made sure that we left the gig completely rocked and well. The only mistake might have been "I Love This Dirty Town" and if I was to decide, I would have them playing "Misled" instead. "Misled" is a gem and should never be left out of the set. Also, part of me like the fact that the Quireboys rocked us at a pretty early hour (they went on 9 pm), but the truth is, I can't think of a better headline act for the first half-day. D.A.D. held that spot, but in my book, that's where the Quireboys belong. Well, it's a matter of opinion and no matter what, the Quireboys were awesome tonight and it's easy to get infected by Spike and the guys honesty and love for playing rock 'n' roll. Don't miss them if they play in a town near you.
4Sound Stage
You wanna talk contrasts? Well, here's one: I went directly from the Quireboys happy and groovy party rock to watch Evergrey play. "Happy" is not the way I'd like to describe Evergrey's metal and frankly, this is not my kind of hard rock at all. But for some reason, I really like Evergrey and I have done so since I got the fantastic Recreation Day (2003) album from a friend many years ago. Now, Evergrey's career has been somewhat up and down since that album and even though no album has been bad, some of them has left me underwhelmed. But with Torn from 2008, the band was back in action again and 2011's Glorious Collision put them back as a big name – at least for me. Last year's fantastic Hymns For The Broken proved that Evergrey are still a big force to be reckoned with and I had looked forward to watching them play songs from that album. When the band opened with the first single of the new album, the brilliant "King Of Errors", I could hear that something was wrong. Not with the guys on stage, but the sound wasn't very good at all. It sounded cramped and the drums sounded like cookie boxes. Too bad on such a killer tune, but I knew (hoped!) that the sound guy would make everything alright. The second song, "Leave It All Behind Us", unfortunately the only song from Glorious Collision this night, also suffered from bad sound and it actually took a while to hear which song it was. Two newies, "The Fire" and "Black Undertow" followed and finally, the sound was getting back on track. If the sound was bad, it sure wasn't anything the affected the crowd as they were right there from go. It was also great to state that the new songs played this night, went down really well. "Blinded" from Recreation Day was great to hear and also "The Masterplan" (In Search Of Truth, 2001) and now the sound problems had been fixed and "A New Dawn" and "Wake A Change" gushed all over us and with the improved sound, these newies really came across well. The atmospheric (if that isn't a word, it is now…) instrumental "When The Walls Go Down" serves more like an intermission or an intro for the big and bombastic "Recreation Day" and that really hit home. The fantastic "Broken Wings" (Torn) and the almost as fantastic "A Touch Of Blessing" (The Inner Circle, 2004) gives an almost epic atmosphere to the night and when they end the whole thing with the grand ballad-like tune "The Grand Collapse", epic is the only word I can think of. Too bad about the bad sound in the beginning because otherwise, Evergrey made a great performance and the light show can't be described as anything other than impressive. The last time I saw them live, at Getaway Rock in 2012 (or was it 2011?) it was in broad daylight and Evergrey played a very good gig, but their epic sound and songs together with the big light show puts the band in the first division as a live act. It's time for the world to discover this band now. God knows they deserve it.
Jon Wilmenius
Photo: Hanna Henrikson


Outdoor Adventure is a camping shop that provides for all different levels of recreational activities, whether its dog walking, hiking or skiing. We aim to provide for every outdoor need. At Outdoor Adventure we aim to train our staff so that they can answer any question you may have in store or online. Check out our About Us page to find out more about Outdoor Adventure.


text:
How to Submit a Guest Column
Submitting a Guest Column
Oregon Political News
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Join the annual Roe v. Wade Memorial Rally in Portland
By In the news
In: Abortion
Oregon Right To Life
Portland, OR—Tomorrow (Sunday, January 17, 2016), in Pioneer Courthouse Square, thousands of Oregonians from around the state will be convening to commemorate the 58 million lives lost to legalized abortion since 1973.
The rally begins at 2:30pm. Following the rally, the attendees will march through downtown Portland, aided by police escort. This year's featured speaker is Lila Rose, president of Live Action, a national pro-life group that has carried out many undercover investigations of Planned Parenthood.
Live Action exposed an employee of the now-closed Clackamas Planned Parenthood teaching BDSM to a girl who gave her age as 15. Additionally, David Daleidan of the Center for Medical Progress, who went undercover for two years in the "fetal parts" industry, got his start working for Ms. Rose at Live Action.
Following the rally and march through Portland, students will attend Oregon Right to Life's second annual youth rally, where Ms. Rose will be speaking again.
Please click here for an event flyer or here to see the event on Facebook
2015 Roe v. Wade Memorial Rally in Portland, OR
Hundreds rally in Beaverton to call for defunding Planned Parenthood
Oliver North, Michael Reagan speaking at March 14 Oregon rally
Conservative rally in Portland draws over 1,500
What's Tina Kotek afraid Oregon will learn about Planned Parenthood?
Subscribe to Oregon Catalyst's mailing list to get regular updates
Oregon Catalyst
Follow The Oregon Catalyst


Catchable-size trout are scheduled to be stocked this week into the following waters.
Fresno - Avocado Lake, Kings River (below Pine Flat Reservoir), San Joaquin River (below Friant Dam), Woodward Park Lake.
Sacramento - Elk Grove Park Pond, Gibson Ranch County Park pond, Granite Park pond, Hagan Park pond, Mather Lake, Howe Park pond, Southside Park pond, William Land Park pond, Willow Hill Reservoir.


text:
The Darkness release official video for new single 'Heart Explodes'
The Darkness have announced they are set to play their forthcoming jaw-dropping quasi-sci-fi concept album Easter Is Cancelled in full, alongside a set of their very greatest hits, on their upcoming headline tour. To mark the announcement the band have released a new video for latest single 'Heart Explodes', taken from Easter Is Cancelled out October 4th via Cooking Vinyl.
The 'Heart Explodes' video captures the band on their recent stadium-sized outdoor tour as personally invited special guests and main support for fellow Suffolk-based musician Ed Sheeran with footage shot both onstage as well as featuring some intimate backstage hijinks.
Looking forward to the forthcoming headline tour frontman Justin Hawkins says, "Uncertain times call for the grandest of gestures. The Darkness are entirely pleased to announce that we will encircle the world with the wings of inclusivity, by performing our new magnum opus, Easter is Cancelled, in full, at ludicrous volume, FOR YOUR EARS AND MINDS! Come with us people - let's fly to a future worth living in..."
Easter Is Cancelled is the band's most exciting and diverse record to date, a mini-rock opera examining the role of the musician in the barbarous culture of the world today. At the heart of the tale is love, loss and heartbreak, where redemption is ultimately found in the brotherhood of band friendship and the power of the guitar.
'Heart Explodes' finds The Darkness baring all in a multitude of heartfelt emotions, while previous single 'Rock And Roll Deserves To Die' saw the band hailing the death of rock and roll in an epic five-minute masterpiece featuring monumental riffs, thunderous bass and almighty drums, alongside some beautifully delicate touches from the band.
As the band's breakthrough 2003 smash hit 'I Believe In A Thing Called Love' surpasses over 100 million streams on Spotify, it's fitting the band now come to release their latest defining album Easter Is Cancelled, which includes material that has been over 16 years in the making, one such track being 'Live 'Till I Die'.
Guitarist Dan Hawkins explains, "That song has been around since before Permission To Land. We played it at really early gigs. We tried recording it for every album, but it never worked. The difference is that Rufus plays on it."
Easter Is Cancelled will be released digitally and in full technicolour physical glory as a standard CD, digipak CD with bonus tracks, gatefold LP, limited edition colour vinyl gatefold LP, Picture Disc and Cassette. The album is available to pre-order now from the band's Official Store with special signed copies and exclusive album bundle offers. The preorder link is: https://thedarkness.lnk.to/EICPR
The Darkness will be spreading their Easter Is Cancelled message across the land with the full UK and Ireland headline tour this winter and will play 18 dates starting in November 2019. These shows promise to be incredibly special, reflecting the grand scope and vision of the album, alongside the finest hits from the band's spectacular canon. Tickets are available here.
THE DARKNESS 'EASTER IS CANCELLED' 2019 TOUR
26th – Belfast, Limelight
27th – Dublin, Academy
29th – Nottingham, Rock City
1st – Birmingham, O2 Academy
2nd – Leicester, O2 Academy
3rd – Southend, Cliffs Pavilion
5th – Norwich, UEA
6th – Cambridge, Corn Exchange
7th – Bath, Pavilions
9th – Portsmouth, Pyramids
10th – Brighton, Dome
11th – Watford, Colosseum
13th – Manchester Academy
14th – Newcastle, O2 Academy
15th – Glasgow, O2 Academy
17th – York, Barbican
18th – Liverpool, O2 Academy
20th – London, Roundhouse
Wilful Publicity
39a Orford Road, Walthamstow, London, E17 9NL.
tel: +44 (0)208 257 6128.
info@wilfulpublicity.co.uk


This section examines some of the various bits of equipment, vehicles and boats used by British Special Forces and elite troops.
Night vision goggles, thermal imagers, leatherman tools, laser target designators etc.
WMIK Land Rovers, All-Terrain Vehicles, Pinzgauer Trucks and the new SAS longe range patrol vehicle.
A look at the helicopters and fixed-wing aircraft which support the Special Forces.
Featuring inflatable raiding craft, RIBS, hovercrafts and offshore raiding craft and other vessels used by UKSF and the Royal Marines.
Read our article on personal kit carried by the Paras.


Two starred PW Select reviews in one month!
In which I announce to the world what's going on with some of the books I've been privileged to edit, some for publishers, some for individual authors. Here's where I remind myself, and anyone else who happens to be looking, what a wonderful job I have.
(Late-breaking news: I woke up New Year's Day to see that Little Known Facts made British blogger booksaremyfavoriteandbest's Top Ten Books for 2013. Way to go Christine!) I'm thrilled to see Christine Sneed's�Little Known Facts�named in Flavorwire's�15 Best Book Covers of 2013. The cover designer is Natalie Slocum. I'd like to encourage every author who plans to self-publish to take cover design�as seriously as editing. Well, almost.
I'm very pleased to see David Vann's Goat Mountain—the third novel I've copyedited for this masterful writer—listed in the San Francisco Chronicle's 100 Recommended Books of 2013�as well as in�the millions.com's Great Second-Half 2013 Book Preview.�I like this review�in the Washington Post, too.
This beautiful photo, of a World War II bomber pilot who was later lobotomized by the US government, comes from the Facebook page—a rich source of poignant glimpses into military history—of journalist and author Louise Esola, a tireless advocate for veterans whose stories might otherwise be forgotten. I'll be beginning work on her book American Boys: The True Story of the Lost 74 of the Vietnam War�in late January.
Elizabeth Gilbert's�Signature of All Things�finished out the year with a bang. After reaching No. 2 on the New York Times best seller list and being named Amazon's Best Book of the Month for October, it made�New York Times critic Janet Maslin's list of her ten favorite books of 2013�(both fiction and nonfiction), Goodreads Best Historical Fiction list, Barnes & Noble's Best New Fiction Books of 2013, No. 4 on Amazon's Best Books of the Year: Literature and Fiction, and�Time magazine's�"Best of Culture 2013." I'm sure I've missed some. . . .
Mitch Albom's First Phone Call from Heaven�hit the ground running, at No. 1 on the New York Times best seller list its first week out.
I spent my early childhood on the Navajo reservation, and I've read all of Tony Hillerman's novels, so working on Anne Hillerman's convincing Leaphorn and Chee sequel meant a lot to me. I even made it out to the book launch party in Santa Fe—a great excuse to revisit the reservation. So I was super pleased to see�Spider Woman's Daughter�at No. 10 on the New York Times�best seller list soon after I got back home—the same week that The Signature of All Things was at No. 4. Things don't get much better than that!


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Center for Jewish Studies Welcomes Deena Aranoff as Director
For immediate release, January 28, 2016 The Richard S. Dinner Center for Jewish Studies (CJS) at the Graduate Theological Union is pleased to welcome Dr. Deena Aranoff as the Center's new director. Dr. Aranoff, who has worked with CJS and served on the GTU faculty since 2006, takes over the role from Dr. Naomi Seidman, who served as CJS director for the previous 16 years. Dr. Seidman will continue to work with CJS and its students as the Graduate Theological Union's Koret Professor of Jewish Literature. Dr. Aranoff, whose teaching specialties include rabbinic literature and medieval Jewish...
CJS | The Richard S. Dinner Center for Jewish StudiesDeena AranoffNaomi Seidman
(-) Remove WSR | Women's Studies in Religion filter WSR | Women's Studies in Religion
(-) Remove Deena Aranoff filter Deena Aranoff
(-) Remove WSR | Women's Studies in Religion filter WSR | Women's Studies in Religion


We ba3dein it's not only gonna be on Sunday that we all suddenly become Egyptians n respect Egypt... konna fein ba2eit el sana??
same idea of ppl. who only love eachother on Valentine's Day!! Lol... ironic, ain't it?
plz stop writing about egypt if u cant -only for 1 day- (10 min kaman) respect her .
3awny eb3at messages l kol el members 2olohom en kollo lazm y salute kol youm el sob7..


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Bulgarian railways offering narrow-gauge railway excursion on August 1
Written by The Sofia Globe staff on July 29, 2021 in Bulgaria - Comments Off on Bulgarian railways offering narrow-gauge railway excursion on August 1
To mark the 95th anniversary of the line, Bulgarian railways BDZ and the narrow-gauge railway fan NGO have organised an excursion on August 1 on the route from Septemvri station to the highest-altitude railway station on the Balkan Peninsula, Avramovo.
In a nod to the fact that such trains used to be mixed passenger and goods trains, this too will have a mixed composition.
The train will include a bistro coach, BDZ said.
The train will depart from Septemvri at 10.45am.
It will stop at Tsepina station, for passengers to visit the narrow-gauge railway museum. The train will then go on to Velingrad, Tsvetino station and Sveta Petka, where in the past steam locomotives would take on water.
The train will remain at Avramovo railway station for 90 minutes, for passengers to go for a walk or picnic.
On the return journey, the train will stop at the Stoyan Mitov station, opened in honour of the centenary of the law that provided for the construction of the narrow-gauge railway, and at Velingrad South station. The train will arrive at Septemvri at 6.35pm.
Return tickets cost 45 leva for one passenger with a reserved seat. Children up to the age of seven travel free, with documentary proof of age required when buying tickets. BDZ issued a reminder that children under the age of 10 must be accompanied by an adult.
Tickets can be bought at the ticket offices at Sofia, Plovdiv, Septemvri, Pazardzhik and Velingrad railway stations.
(Photo: BDZ)
Bulgarian railways offering narrow-gauge steam train trips on September 4, 5 and 6
Bulgarian railways offering steam train excursion on June 26
Tickets for Bulgarian railways' June steam train excursions go on sale
Bulgarian railways organising two more steam train trips in June


They talk in every article about capturing French style or Parisian allure, French beauty, and that certain je ne sais quoi. Well the secret about come to light now: there is no magic formula, it's all about personal style.
Sabina Socol has a playful French style. She loves vintage pieces and she styles them in a trendy yet timeless way.


The Stuttering Brain: Do bats stutter?
Does anyone have any currently available solutions to a hypersensitivity to background noise/ higher pitched voice/ sound?
Exceptional picture and article about the bats, Tom.
Great Bat picture! Looks like one of my former speech therapists.


This notice describes how medical information about you may be usedand disclosed and how you can get access to this information.
All departments within the Proctor Health Care, Inc. organization.
All employees, staff and other organizational personnel.
Any healthcare professional authorized to enter information into your medical chart.
*A listing of Proctor Health Systems offices and Illinois Institute of Addiction Recovery satellite sites can be obtained from our Privacy Officer.
It is the policy of Proctor Health Care, Inc. to function as an Organized Health Care Arrangement (OHCA). All these entities, sites and locations follow the terms of this notice. In addition, these entities, sites and locations may share medical information with each other for treatment, payment or operations purposes as described in this notice.
We understand that medical information about you and your health is personal. We are committed to protecting medical information about you. We create a record of the care and services you receive at our organization. We need this record to provide you with quality care and to comply with certain legal requirements. This notice applies to all of the records of your care generated by the organization, whether made by organizational personnel or your personal doctor. Your personal doctor may have different policies or notices regarding the doctor's use and disclosure of your medical information created in the doctor's office or clinic.
The following categories describe different ways that we use and disclose medical information. For each category of uses or disclosures, we will explain what we mean and try to give some examples. Not every use or disclosure in a category will be listed. However, all of the ways we are permitted to use and disclose information will fall within one of the categories.
For Treatment – Our organization may use medical information about you to provide you with medical treatment or services. We may disclose medical information about you to doctors, nurses, technicians, medical students, or other organizational personnel who are involved in your care. For example, a doctor treating you for a broken leg may need to know if you have diabetes because diabetes may slow the healing process. In addition, the doctor may need to tell a dietitian if you have diabetes so that we can arrange for appropriate meals. Different departments of the organization also may share medical information about you in order to coordinate the different things you need, such as prescriptions, lab work and x-rays. We also may disclose medical information about you to people outside the organization who may be involved in your medical care after you leave our facility, such as family members, clergy or others we use to provide services that are part of your care.
For Payment – We may use and disclose medical information about you so that the treatment and services you receive at our organization may be billed to and payment may be collected from you, an insurance company or a third party. For example, we may need to give information about surgery you received at our organization to your health plan, so your health plan will pay us or reimburse you for the surgery. We may also tell your health plan about a treatment you are going to receive to obtain prior approval or to determine whether your plan will cover the treatment.
For Healthcare Operations – We may use and disclose medical information about you for organizational operations. These uses and disclosures are necessary to run the organization and make sure that all of our patients receive quality care. For example, we may use medical information to review our treatment and services and to evaluate the performance of our staff in caring for you. We may also combine medical information about many patients to decide what additional services the organization should offer, what services are not needed, and whether certain new treatments are effective. We may also disclose information to doctors, nurses, technicians, medical students, and other organizational personnel for review and learning purposes. We may also combine the medical information we have with medical information from other healthcare organizations to compare how we are doing and see where we can make improvements in the care and services we offer. We may remove information that identifies you from this set of medical information so others may use it to study health care and health care delivery without learning who the specific patients are.
Patient Satisfaction Surveys -We may use and disclose information to contact you either by mail or phone to obtain information regarding your satisfaction with the treatment or services you received at our facilities.
Appointment Reminders -We may use and disclose medical information to contact you as a reminder that you have an appointment for treatment or medical care at one of our facilities.
Treatment Alternatives -We may use and disclose medical information to tell you about or recommend possible treatment options or alternatives that may be of interest to you.
Hospital Directory – We may include certain limited information about you in the hospital directory while you are a patient at the hospital. This information may include your name,location in the hospital, your general condition (e.g., good, fair, etc.) and your religious affiliation. The directory information, except for your religious affiliation, may also be released to people who ask for you by name. Your religious affiliation may be given to a member of the clergy, such as a priest or rabbi, even if they don't ask for you by name. This is so your family, friends and clergy can visit you in the hospital and generally know how you are doing.
Individuals Involved in Your Care or Payment for Your Care -We may release medical information about you to a friend or family member who is involved in your medical care. We may also give information to someone who helps pay for your care. We may also tell your family or friends your condition and that you are in the hospital. In addition, we may disclose medical information about you to an entity assisting in a disaster relief effort so that your family can be notified about your conditions, status and location.
Research – Under certain circumstances, we may use and disclose medical information about you for research purposes. For example, a research project may involve comparing the health and recovery of all patients who received one medication to those who received another, for the same condition. All research projects, however are subject to a special approval process. This process evaluates a proposed research project and its use of medical information, trying to balance the research needs with the patients' need for privacy of their medical information. Before we use or disclose medical information for research, the project will have been approved through this research approval process, but we may, however, disclose medical information about you to people preparing to conduct a research project, for example, to help them look for patients with specific medical needs, so long as the medical information they review does not leave the organization. We will almost always ask for your specific permission if the researcher will have access to your name, address or other information that reveals who you are, or will be involved in your care at the hospital.
As Required by Law -We will disclose medical information about you when required to do so by federal, state or local law.
To Avert a Serious Threat to Health or Safety -We may use and disclose medical information about you when necessary to prevent a serious threat to your health and safety or the health and safety of the public or another person. Any disclosure, however, would only be to someone able to help prevent the threat.
Military and Veterans -If you are a member of the armed forces, we may release medical information about you as required by military command authorities. We may also release medical information about foreign military personnel to the appropriate foreign military authority.
to notify the appropriate government authority if we believe a patient has been a victim of abuse, neglect or domestic violence. We will only make this disclosure if you agree or when required or authorized by law.
Health Oversight Activities – We may disclose medical information to a health oversight agency for activities authorized by law. These oversight activities include, for example, audits, investigations, inspections, and licensure. These activities are necessary for the government to monitor the healthcare system, government programs, and compliance with civil rights laws.
in emergency circumstances when necessary to maintain safety and security of our personnel and patients.
Coroners, Medical Examiners and Funeral Directors – We may release medical information to a coroner or medical examiner. This may be necessary, for example, to identify a deceased person or determine the cause of death. We may also release medical information about patients of the hospital to funeral directors as necessary to carry out their duties.
National Security and Intelligence Activities – We may release medical information about you to authorized federal officials for intelligence, counterintelligence, and other national security activities authorized by law.
Protective Services for the President and Others – We may disclose medical information about you to authorized federal officials so they may provide protection to the President, other authorized persons or foreign heads of state or conduct special investigations.
Inmates – If you are an inmate of a correctional institution or under the custody of a law enforcement official, we may release medical information about you to the correctional institution or law enforcement official. This release would be necessary (1) for the institution to provide you with health care; (2) to protect your health and safety or the health and safety of others; or (3) for the safety and security of the correctional institution.
Federal and State Law – Federal and state laws require us to protect your medical information, and federal law requires us to describe to you how we handle that information. When state and federal privacy laws differ, and Illinois law is more protective of your information or provides you with greater access to your information, then state law will override federal law.
Right to Inspect and Copy – You have the right to inspect and to request a copy of information maintained in our records about you. This includes medical and billing records maintained and used by us to make decisions about your care. In certain situations, where providing access may be detrimental to your health, we are permitted by state and federal law to withhold access. To obtain or inspect a copy of your medical information, submit a written request to our Privacy Officer. We may charge a reasonable, cost-based fee to cover the expense of providing the copies.Most patients have full access to inspect and receive a copy of the full medical record. On rare occasions, we may deny a request to inspect and receive a copy of some information in the medical record. This may occur if, in the professional judgment of your physician, the information could cause a threat to you or others. In these cases, we may supply the information to an appropriate third party who may then release the information to the patient.If you are denied access to information, you may request a review of the denial. Another licensed health-care professional who was not involved in the original decision by us will independently review both the original request and denial. Contact our Privacy Officer for more information.
Denial of a Requested Amendment – If we deny your request for an amendment, we will give you a written explanation for the denial. If you still disagree with the explanation provided, you can submit your written disagreement to our Privacy Officer, or you can ask that your request for amendment and explanation of the denial be included in any future disclosure of the pertinent protected health information. If you submit a statement of disagreement, we may write a rebuttal to your statement of disagreement that will be included in your record.
To request this list or accounting of disclosures, you must submit your request in writing to our Privacy Officer. Your request must state a time period, which may not be longer than six years and may not include dates before April 14, 2003. The first list you request within a 12-month period will be free. For additional lists, we may charge you for the costs of providing the list. We will notify you of the cost involved and you may choose to withdraw or modify your request at that time before any costs are incurred.
Right to Request Restrictions – You have the right to request a restriction or limitation on the medical information we use or disclose about you for treatment, payment or health care operations. You also have the right to request a limit on the medical information we disclose about you to someone who is involved in your care or the payment for your care, like a family member or friend. For example, you could ask that we not use or disclose information about a surgery you had.To request restrictions, you must make your request in writing to our Privacy Officer. In your request, you must tell us (1) what information you want to limit; (2) whether you want to limit our use, disclosure or both; and (3) to whom you want the limits to apply, for example, disclosures to your spouse.We will carefully consider all requests. However, because of the integrated nature of our medical record, we are not generally able to honor most requests, nor are we legally required to do so.
Right to Request Confidential Communications – You have the right to request that we communicate with you about medical matters in a certain way or at a certain location. For example, you can ask that we only contact you at work or by mail.To request confidential communications, you must make your request in writing to our Privacy Officer. We will not ask you the reason for your request. We will accommodate all reasonable requests. Your request must specify how or where you wish to be contacted.If the request could result in our not being able to collect payment for services, we reserve the right to require you to provide additional information about how payment for services will be handled.
Authorization – Except as described above or specifically required or permitted by law, we will not use or disclose your medical information without a specific authorization from you. At times, we may ask you to provide a specific written permission to allow us to use or disclose medical information about you.
An authorization is your signed, written permission to release medical information. You may be asked to sign the same authorization form periodically as required by state or federal law.
An authorization may be revoked in writing at any time. Written revocation of authorization must be submitted to our Privacy Officer.
We reserve the right to change this notice. We reserve the right to make the revised or changed notice effective for medical information we already have about you as well as any information we receive in the future. When the notice is revised, we will post a copy of the current notice in the organization and it will also be available at our website, www.proctor.org. The notice will contain on the first page, within the title section, the effective date. In addition, each time you register at a facility or are admitted to the hospital for treatment or health care services as an inpatient or outpatient, we will offer you a copy of the current notice in effect.
We honor your right to file a concern or complaint. We would not, nor could we legally or ethically, take action against you for filing a concern or complaint. We reserve the right, however, to take necessary and appropriate action to maintain an environment that serves the best interest of our patients and providers.
Other uses and disclosures of medical information not covered by this notice or the laws that apply to us will be made only with your written permission. If you provide us permission to use or disclose medical information about you, you may revoke that permission, in writing, at any time. If you revoke your permission, we will no longer use and disclose medical information about you for the reasons covered by your written authorization. You understand that we are unable to take back any disclosures we have already made with your permission, and that we are required to retain our records of the care that we provided to you.


We are looking for service-oriented team players, with a great attitude and adaptability to a changing, dynamic environment.
We have a strong volunteer focus to assist the communities in which we do business.
We believe kstate CREDIT UNION is a special place, a place where we are committed to building lifelong relationships and serving our members' financial needs.
Join our growing team as a Flexible Full or Part-Time Member Service Specialists. Applicants must be confident, have an outgoing personality, detail-oriented, ability to multi-task, and can offer solutions to meet member needs. Teller experience is preferred, but not required.


We need volunteers to play around with our new cellphone platform for farmers who only have simple cellphones and no internet access - US-based cellphones only for this test (to save on costs).
What can we achieve with such a basic level of communication, and how can we explore different scenarios for its use?
How does the platform really work, and how can we build experience using it and explain it to the farmers when they start their training?
We need people with no previous experience, so that we can learn from you what it's like to sign up and join the community.
We will also welcome people who want to get more involved, answering questions and helping to improve the operation of the platform.


Being interested in the stock market, certain stocks specifically, I decided to follow ten different companies for a period of 91 days. These stocks include some of my own, some I am interested in, and some of the most active stocks during the week I began my project, September 1, 1973. They are listed in the New York Stock Exchange, the American Stock Exchange, and Unlisted Stocks.
To begin my investigation I recorded the closing price every day of each company, in order to show increases, decreases, and fluctuations. By doing this I was constantly aware of what stock I was making money on and what I needed to sell. Second, I decided on the number of shares I had purchased, some real, some imaginary, and a purchase date for each. The last day of my project was the selling day, November 30, 1973, and each profit or loss was recorded.
During the days I recorded closing prices, I did research on each company - its purpose, its goals, and its profits. The descriptions were taken from Standard and Poor's, August, 1973, and the general information from the annual report of each company for 1973.
I encountered several problems during my project. 1) Trying to record my over-the-counter stock, Overseas Inn, was sometimes a problem. Over-the-counter stocks were only listed about once a week due to lack of space. 2) One of my stocks listed as "Lucky Str." I had picked to compare with Liggett &Myers. I was planning to compare "Lucky Strike" cigarettes with Liggett & Myers brand. After gathering my information "Lucky Str." turned out to be "Lucky Stores", a food chain in California. 3) Because of the political unrest my stock was never consistent. Noticeable drops occurred during the Watergate hearings, when Vice-President Agnew resigned, and when Nixon made his talks on the energy crisis.
Overall I think the project was very successful, both money-wise and educationally. Although the information I gathered could be applied to any stock, the ten that I recorded were of special interest to me. I realize that the United States had many problems during the ninety days I chose. Any other time the market might have been better off. Instead of continuing the project, however, I chose to end it at the stated time. In a month, it may be prospering or still declining. The purpose was not to make a profit, but to illustrate how the stock market works.
Gladden, Beth, "A Look at Today's Stock Market" (1973). Honors Theses. 387.


When the State of Washington enacted its Craft Distillery legislation on July 1st, 2008, the concept for Batch 206 was born. The following information is a little bit about Batch 206 Distillery in Seattle, WA and information about its team!
Just as Seattle is known worldwide for innovation in design, science and technology, aerospace engineering, music, agriculture, architecture and coffee. As Seattleites, Batch 206 believe spirits conceived in Seattle by folks who live and work in the Seattle area have a good chance to capture the essence of this great city and should, like the aforementioned categories, resound worldwide.
Liberty Spirits Asia is the distributor and supplier for Batch 206 Distillery's Counter Gin, Batch 206 Vodka, Mad Mint Vodka, and See 7 Stars Moonshine in Singapore, Hong Kong, and Malaysia.