text:
Q: Bouncycastle and PKCS #1 v2.1, Signing with RSASSA-PSS & Encrypting with AES CBC with RSAES-OAEP After countless hours spent with this library I still can't get it work.
I want to send smime messages with the bouncy castle library, signed with the RSASSA-PSS, encrypted with AES, where the key transport should be RSAES-OAEP, all P1#v2.1
Signer first, this is how it's created:
SMIMESignedGenerator gen = new SMIMESignedGenerator();
            SignerInfoGenerator signer
            = new JcaSimpleSignerInfoGeneratorBuilder()
            .setProvider("BC")
            .build("SHA256withRSAAndMGF1", pk.getPrivateKey(), pk.getCertificate()
            );
gen.addSignerInfoGenerator(signer);
        gen.addCertificates(certStore);
        MimeMultipart mmp = gen.generate(message);

So now when it should be signed, encrypting and using OAEP padding:
    OutputEncryptor enc = new BcCMSContentEncryptorBuilder(CMSAlgorithm.AES192_CBC).build();
        SMIMEEnvelopedGenerator gen = new SMIMEEnvelopedGenerator();

        for (X509Certificate nCert : certs) {
                RecipientInfoGenerator keyTransportRecipient =
                new JceKeyTransRecipientInfoGenerator(nCert).setProvider("BC").
setAlgorithmMapping(PKCSObjectIdentifiers.rsaEncryption, "RSA/ECB/OAEPWithSHA256AndMGF1Padding");
                gen.addRecipientInfoGenerator(keyTransportRecipient);
        }
                MimeBodyPart encryptedMimeBodyPart = gen.generate(message, enc);

I could not find the proper setAlgorithmMapping() description, so I did try following combinations:
.setAlgorithmMapping(PKCSObjectIdentifiers.rsaEncryption, "RSA/NONE/PKCS1Padding");
.setAlgorithmMapping(PKCSObjectIdentifiers.rsaEncryption, "RSA/ECB/OAEPWithSHA256AndMGF1Padding");
.setAlgorithmMapping(PKCSObjectIdentifiers.id_RSAES_OAEP, "RSA/ECB/OAEPWithSHA56AndMGF1Padding");

btw, can anyone please explain, what exactly this pattern means here -  "RSA/ECB/OAEPWithSHA256AndMGF1Padding"?
Am I right if the first param is the public key algorithm, second "ECB" is I suppose ECB AES mode? (I tried CBC mode also, but got no such algorithm exception, tried NONE also) And the last ("OAEPWithSHA56AndMGF1Padding") is apparently OAEP p1#v2.1, which I actually want.
So, at this point messages should be signed & encrypted.
When I check my mailbox now (with Thunderbird), it says: "Thunderbird cannot decrypt this message", "The sender encrypted this message to you using one of your digital certificates, however Thunderbird was not able to find this certificate and corresponding private key."
But, when I was signing with old signer
build("SHA256withRSAEncryption", pk.getPrivateKey(), pk.getCertificate()

and used the old key transpport scheme, which was
setProvider("BC").setAlgorithmMapping(PKCSObjectIdentifiers.rsaEncryption, "RSA/NONE/PKCS1Padding");

everything worked fine. So apparently my self-signed x509 certificate is not the problem here, please correct me if I'm whong here.
I also tested it with Outlook (2013)
Old scheme (SHA256withRSAEncryption signing + PKCS1Padding key transport) -> Everything is fine.
New scheme (SHA256withRSAAndMGF1 signing + RSA/ECB/OAEPWithSHA256AndMGF1Padding) -> "Your Digital ID name cannot be found by the underlying security system" Error.
At this point I have no idea what's is actually wrong.
This is how I create certificate with openssl:
openssl req -new -x509 -nodes -sha256 -days 365 -newkey rsa:2048 -out certificate.cer -keyout private.key -sigopt rsa_padding_mode:pss -sigopt rsa_pss_saltlen:32 -passin pass:mypass -utf8 -config _openssl.cfg -extensions v3_req
openssl pkcs12 -export -out certificate.pfx -name "testname" -inkey private.key -in certificate.cer

A: Giving an AlgorithmIdentifier for RSA-OAEP to the OutputEncryptor is the wrong way. It will (at least for me) result in an error like this:
 ... no such algorithm: 1.2.840.113549.1.1.7 for provider BC

If you want to use AES and RSA-OAEP then you have to assign AES to the OutputEncryptor (who is responsible for symmetric encryption)
and RSA-OAEP to the RecipientInfoGenerator (who is responsible for key encryption respectively asymmetric encryption).
Here is the code:
(The definition of the OAEPParameterSpec was already correctly explained in a previous post here).
// Note that at JcaAlgorithmParametersConverter is available since BC 1.50.
JcaAlgorithmParametersConverter paramsConverter = new JcaAlgorithmParametersConverter();
OAEPParameterSpec oaepParameters = new OAEPParameterSpec("SHA-256", "MGF1", new MGF1ParameterSpec(
        "SHA-256"), PSource.PSpecified.DEFAULT);
AlgorithmIdentifier idRsaOaep = paramsConverter.getAlgorithmIdentifier(PKCSObjectIdentifiers.id_RSAES_OAEP, oaepParameters);

SMIMEEnvelopedGenerator encryptor = new SMIMEEnvelopedGenerator();

// Assign OAEPParameterSpec and an instance of X509Certificate to the RecipientInfoGenerator.
// prov is an instance of BouncyCastleProvider.
encryptor.addRecipientInfoGenerator(new JceKeyTransRecipientInfoGenerator(certificate, idRsaOaep)
        .setProvider(prov));

// Use an OutputEncryptor with AES.
OutputEncryptor outputEncryptor = new JceCMSContentEncryptorBuilder(CMSAlgorithm.AES128_CBC)
        .setProvider(prov)
        .build();

// Do encryption (were plaintextMsg is a MimeMessage instance).
MimeBodyPart payload = encryptor.generate(plaintextMsg, outputEncryptor);

A: I think I solved your problem. At least in my case it's working.
For the AlgorithmIdentifier for PKCSObjectIdentifiers.id_RSAES_OAEP I added the following lines of code:
pubilc AlgorithmIdentifier getAlgo() {

        JcaAlgorithmParametersConverter paramsConverter = new JcaAlgorithmParametersConverter();
        OAEPParameterSpec oaepSpec = new OAEPParameterSpec("SHA-256", "MGF1", new MGF1ParameterSpec("SHA-256"), new PSource.PSpecified(new byte[]{1, 2, 3, 4, 5}));
    return paramsConverter.getAlgorithmIdentifier(PKCSObjectIdentifiers.id_RSAES_OAEP, oaepSpec);
}

With this parameterized AlgorithmIdentifier you can now encrypt you message:
AlgorithmIdentifier algo = getAlgo();
    SMIMEEnvelopedGenerator encrypter = new SMIMEEnvelopedGenerator();
    RecipientInfoGenerator keyTransportRecipient =
                            new JceKeyTransRecipientInfoGenerator(cert).setProvider("BC").setAlgorithmMapping(PKCSObjectIdentifiers.id_RSAES_OAEP, "RSA/ECB/OAEPWithSHA256AndMGF1Padding");

encrypter.generate(bodyPart, new JceCMSContentEncryptorBuilder(algo).setProvider("BC").build());                            encrypter.addRecipientInfoGenerator(keyTransportRecipient);

Did you have any success on the signing issue? In my case, Outlook says the signature is not valid.

A: The problem I think is that most S/MIME clients do not support
RSASSA-PSS. The only tool (besides BC) I found that supports verifying
S/MIME RSASSA-PSS signatures is a recent version of openssl.
According to the openssl documentation, this requires openssl >= 1.1.0.
openssl cms -verify -in email.eml -CAfile root.pem
This only works with the openssl cms command and not with the openssl
smime command.

redpajama_set_name: RedPajamaStackExchange


"What happens to people on diets in the long run?" Mann asked. "Would they have been better off to not go on a diet at all? We decided to dig up and analyze every study that followed people on diets for two to five years. We concluded most of them would have been better off not going on the diet at all. Their weight would be pretty much the same, and their bodies would not suffer the wear and tear from losing weight and gaining it all back."


text:
Two wanted persons arrested in Tirana for fining a citizen with € 21,000
By Oculus News Monday, January 13, 2020 Crime
Tirana police have arrested two people, well known for Albanian and Italian justice after they asked with pressures and intimidations 21,000 euros from a person.
The two dangerous persons have been arrested; both of them have been using two names, and both of whom were previously convicted.
Police notification:
Police operation "MEETING" is finalized.
The Operation by Police Commissariat Nr. 2, in cooperation with the Special Operational Task Force of the Tirana Local Police Directorate.
They have placed a fine of 21,000 euros on a citizen and left a meeting to receive the money, but they were arrested by the police.
A 43-year-old man was arrested with the security measure "Home Arrest", a person suspected of criminal activity in Italy, as well as a 37-year-old man wanted by the Tirana Police Commissariat Nr. 2.
Crime Investigation Specialists at Police Station no. 2, after receiving information that two citizens had placed a fine to a citizen and left a meeting to receive the money, have organized the work and in cooperation with the Special Operations Task Force in Tirana DVP, using proactive methods, organized and finalized the police operation codenamed "MEETING".
As a result of the operation, near the Aviation Field, it was possible to block the vehicle which was driven by two suspected N.F. alias A.T., 37, resident in Durres, declared wanted by Police Station no. 2 and E. L. alias G. G., 43, a resident of Tirana, wanted in Italy after the Milan Court issued an arrest warrant for the criminal offenses "Criminal cooperation for drug trafficking"..]
At the moment of detention of the vehicle by the police, equipped with phenolines and police sirens, these citizens gave other generals to the Police services, but after being escorted to the Police premises and after the verifications carried out it turned out that both of them were announced wanted...
Two wanted persons arrested in Tirana for fining a citizen with € 21,000 Monday, January 13, 2020 Rating: 5

redpajama_set_name: RedPajamaCommonCrawl


text:
Published: 0513 GMT October 10, 2019
Thousands of terrorists may escape from jail as Turkey attacks northern Syria
Fears are growing that thousands of Daesh terrorists may escape from Syrian jails, as Kurdish prison guards are reportedly leaving their posts to gear up for fighting back the Turkish military that has started an operation against Kurds in northern Syria.
US officials on Wednesday confirmed to CNN that some militants from the US-allied Syrian Democratic Forces (SDF) had already left their posts at various jails holding Daesh prisoners and headed north before the Turkish offensive began, presstv.ir reported.
The US Defense Department Inspector General had also warned in June that Daesh had established "resurgent cells" in Syria.
Hundreds of Daesh prisoners continue to be held in makeshift prisons close to the Turkish border, according to US defense officials.
The CNN report said that officials have long warned of the vulnerability of the "pop-up prisons" housing some 11,000 to 12,000 Daesh militants captured on the battlefield, 2,000 of whom are foreigners not from Iraq or Syria.
Amid growing concerns over the escape of those prisoners, the US president said Wednesday some of the most dangerous Daesh inmates had been moved to "other areas where it's secure."
Hours after Donald Trump's announcement, a US defense official confirmed to ABC News that the US military has taken custody of two "high value individuals" - from the SDF. The two are said to be the British Daesh "Beatles" terrorists notorious for videotaping beheading of captives by the Takfiri group.
"They are being held in US military custody pursuant to the law of war. They have been moved out of Syria and are in a secure location."
In an interview with PBS News Hour, US Secretary of State Mike Pompeo acknowledged that there are Daesh "remnants" in Syria.
"We have taken down the caliphate," he said, using the term to describe Daesh's territorial presence. "There are ISIS remnants that remain," Pompeo added, using another acronym for the militant group.
The Kurdish-led force that controls northeastern Syria said a Turkish airstrike on Wednesday hit a prison holding detained Daesh militants.
"One of the prisons that Daesh detainees (are) held in was struck by a Turkish airstrike," the SDF said in a tweet, without giving further details.
According to a statement by the Turkish Defense Ministry, the country's military has so far hit 181 positions of the People's Protection Units (YPG) -- the SDF's backbone -- in northern Syria.
The Turkish incursion officially started earlier on Wednesday after the US president gave his Turkish counterpart Recep Tayyip Erdogan the green light to proceed with his long-planned move against Kurdish fighters.
In his PBS interview, Pompeo denied that the US had given a de facto go-ahead to Erdogan. "Well, that's just false. The United States didn't give Turkey a green light."
Donald Trump's decision to "betray" his country's Kurdish allies has provoked a backlash from Republican allies.
Infuriated with Trump for approving Turkey's offensive, Sens. Lindsey Graham, R-S.C. and Chris Van Hollen, D-Md. are turning to sanctions legislation.
Hours after Turkey began its incursion into Syria, the pair released the outline for a wide-ranging Turkey sanctions bill targeting Ankara's defense and energy sectors as well as top Turkish officials, including President Erdogan. The sanctions would expire when Turkey ends its incursion into northeastern Syria.
"While the administration refuses to act against Turkey, I expect strong bipartisan support," Graham wrote while releasing the sanctions bill outline on Twitter.
Kurdish-led SDF militants move children of Daesh terrorists to own camp in northern Syria: Report
US firm Blackwater training Daesh terrorists in Iraq, eyeing Syria: report
France won't take back Daesh terrorists, their families captured in Syria: Interior minister
Turkey captures four Daesh suspects near border with Syria
Daesh terrorists executing local residents in Syria's Dayr al-Zawr, top UN official warns
Daesh terrorists kill 60 US-backed SDF militants in Syria's Dayr al-Zawr
Most heavy arms pulled out of planned Syria buffer zone
US, allies set up more Syria posts, risking standoff with Turkey
Anadolu: Turkey detains 143 people over suspected Daesh links


Where to begin with India?! I had been wanting to go to India for a very long time, and finally we booked our trip (me and my boyfriend) for December. We visited Delhi, Agra, Taj Mahal, Jaipur and Varanasi.
We flew with Finnair and the vegan meal was bean balls, sweetcorn, rice and salad, which was ok but the best bit was the fruit smoothie. The snack was a hummus sandwich, which again was ok nothing special.
We booked a tour with Yolo India Tours and they were very good, they were quick in replying to emails. The choice of hotels were good in Agra, but not amazing in Delhi, Jaipur or Varanasi.
We visited a Hindu temple, where we got to visit the kitchens and help make roti.
We visited Delhi and there are people, cars/motorbikes/tuk tuks and animals everywhere. The noise and population is something I will remember for a long time!
We saw the Red Fort, Jama Masjid, Chandni Chowk (market area), Ghandhi's memorial, India Gate, Presidential Palace, Agrasen ki Baoli (step well used in Bollywood films). In the market area we saw men having their breads trimmed and even getting their ears cleaned with tweezers!!!
To eat vegan in India should be easy because the country is generally vegetarian, but they cook a lot in ghee (clarified butter). Although there is a change to cooking in oil because ghee is more expensive. We basically ate the same food for lunch and dinner, and sometimes breakfast! We ate chickpea curry (chana), vegetable curry, spinach curry (saag), potato curry (aloo gobi), lentil curry (dal) and roti/chapati. Be careful that naan bread normally contains butter and/or yoghurt, and paneer means cheese. In all the food photos it will be a combination of these curries and bread.
We took the train very early in the morning to Agra, it took less than two hours from Delhi or Agra. The train culture is big in India, so it was a definite must for me go on at least one train. We did get a vegan breakfast on the train, it contained bean/sweetcorn deep fried fingers, four (!) chips, peas, bread, jam and butter (!), tea. The food was not amazing.
We went to the Agra Fort, and was pleasantly surprised at how nice it was. Then we had sunset at Taj Mahal, which was beautiful. The next day we also had the sunrise at Taj Mahal and that was worth it. Be careful about people selling fraud tickets outside, we had some English man come up to us saying that the queue was too long and he was selling the tickets for 50% off-not true!
We also had food at our guides house, his wife made us potato curry, lentil curry and roti.
Fatehpur Sikri is an abandoned city near Agra and was worth going to, along with the Jama Masjid mosque. Although in the mosque some man tried to hit my head with a stick because it will bring me good luck! There are also cute goats outside!
On the way to Jaipur we drove to Chand Baori, a stepwell.
In Jaipur we saw the Amer Fort (we did not take the elephants to the fort) and inside there is a Mirror Palace and it is stunning.
We also saw Hawa Mahal (we had to cross the street to take the photos which was incredibly scary)!
We saw the solar observatory and City Palace. We also saw how carpets are hand made and block printing.
This place is crazy! We started in Sarnath, where Buddha gave his first sermon. While here many school children wanted photos with us because we are westerns, this has happened many times during this trip where people stop us and ask for photos. Not going to lie it felt great!
Then it was time for the Ganges, we did a sunset and sunrise boat tour. The views are amazing from the boat, we saw many people washing themselves and their clothes in the Ganges, and even someone swimming! We saw the different ghats, and the Manikarnika Ghat where they burn bodies. At night time we saw an Aarti ceremony.


Hey Blizzard Watch, it's hammer time! At the beginning of each new expansion, Protection Paladins face the decision of how to get the cap and be ready to raid with our guilds in the most expeditious way possible. For pretty much every prior expansion, the best advice told us to put away our shield, speak softly, and carry a big stick.
I'm a bit of a contrarian myself, and fortunately Protection leveling has some inherent benefits in Legion.
Changes are coming to our beloved Tankadin. Old spells are going away, new spells are coming, and some spells, like Avenging Wrath, are coming back. Leveling as Protection gives you plenty of practice working through your new rotation until it becomes second nature. By the time you start into dungeons and raids, you'll be able to concentrate on whatever terrible thing the boss is about to do while your rotation is on auto-pilot. It will also give you opportunities to adjust to the new longer cooldowns on our emergency buttons.
Playing as Protection gives you access to both Rebuke and Avenger's Shield's interrupt. Throw in a couple of Grand Crusader procs, and you can lock down caster mobs limiting the damage they can do to you.
The death penalty in World of Warcraft hints at our most valuable resource while leveling. Running back to your body, resurrecting, and healing back up costs precious time. As every Goblin will be quick to remind you, "Time is money, friend." You are far less likely to die in the field as Protection than you are as Retribution. With the loss of Selfless Healer, Ret Paladins no longer have a way to get an instant Flash of Light. Ifthey get low on health, they have to stop attacking to cast a heal. As Protection, Light of the Protector is instant cast and we even have an Artifact Trait that buffs it.
A tangent to the whole not dying thing is having little fear pulling a rare (silver dragon) mob. All the rares I've encountered in Legion are multi-tap which encourages other players to jump in and help you kill it, but they want someone else to get the party started. Rares have some nice drops and many of the items I found that grant Artifact Power came from killing them.
I spent my early WoW career, from patch 1.9 through Cataclysm, on the PVP server Altar of Storms. While leveling in each expansion, when enemy players saw me in Protection spec, often they would choose to not engage me. Most other classes see us as time-consuming to kill. They often use unflattering insectoid metaphors, but this is mainly born of frustration.
If you find yourself on a PVP server, another option is to party up and party on, excellent, with a cross-realm friend from a PVE server to level.
Pulling an entire camp and using AOE to take it down is the quintessential Tankadin leveling plan going back to the days of the "Porcupine" spec fueled by Holy Shield, Reckoning, Redoubt, Retribution Aura, and a Shield Spike for good measure. We get Retribution Aura back in Legion, and I'm a fan of Last Defender talent — tailor made for that old "CC = Continuous Consecration" gameplay.
For any previous expansion, Ret's Lightning McQueen speed more than made up for Protection's perks, nice as they are. This time around, however, we also have to consider the Artifact.
You need to level up your Artifact with its associated Traits and Relics. If you aren't familiar with how the Artifact works with dual spec, please check out this column by a handsome Dwarf I know. You'll have both the Protection Artifact, Truthguard, and the Retribution Artifact, Ashbringer, for the lion's share of your leveling, but consider which one you'll get first. I'm not sure about the other zones, but both in Stormheim and again in Highmountain, I found quests that awarded Relics. If you get these quests before level 102, you will only have one Artifact and you only get the Relics for the Artifact you have, regardless of your spec when you turn the quest in. Once you have two Artifacts, you get the Relic for the currently equipped one. Had I taken Ashbringer first, I would have gotten Ret Relics from those early quests. Since I took Truthguard first, I got the Prot Relics and one of them was a nice boost to my soloing, and another was for the best Artifact Trait in the game.
The next question becomes how to divvy up your precious Artifact Power. Each Artifact has separate Artifact Power, so there are a couple of different paths you could take.
Truthguard with Artifact Power: Level as Protection with Truthguard and spend your Artifact Power on Truthguard. You won't need to play catch up as you approach max level.
Ashbringer with no Artifact Power: Level as Ret with Ashbringer but spend most of your Artifact Power on your Truthguard. Again, you won't need to play catch up, but the Artifact Power isn't helping as you level.
Ashbringer with Artifact Power: Level as Ret with Ashbringer and spend most of your Artifact Power on Ashbringer with the plan you'll catch up your Truthguard at or near max level.
Ret with a maxed out Ashbringer should do more DPS and by extension kill stuff faster than Prot with a maxed Truthguard. If that's not a true statement, then something is wrong with the class balance, but we have no intention of maxing out our Ashbringers, pretty as they are — at least not right away. We want to dump most of our Artifact Power into leveling up our Truthguard.
When you reach raids, there will only be two tanks and the boss is only going to hit one at a time (for the most encounters). Either you can take the hits and not run your healers out of mana or you can't. On the flip side, there are many other DPS in the raid. If you're a little light on DPS, a dedicated DPS player can help make that up. If you are a little light on surviving pretty much all the raid will be doing is looking through your pockets for loose change.
But Ashbringer isn't the only Artifact that can boost your DPS: several Traits for Truthguard do so as well. Our DPS traits increase DPS by a flat 1% when you open them. Righteous Crusader increases Shield of the Righteous' damage and Truthguard's Light increases all your Holy damage (and really, what do we do that isn't Holy damage).
I decided to do a little test, Mythbusters style. I engaged a bunch of normal mobs in my Protection spec using Truthguard with two Relics and two ranks in one Trait. I then went back over the same area as Ret with my Ashbringer that had no Relics and 0 Artifact Power.
Though it represents a subjective measure and may represent a preexisting bias, I will say I enjoyed my time as Prot more than Ret. Ret felt disjointed, like something was missing, and didn't flow as well as Prot did.
My objective metric was Time to Kill (TTK). I picked a place in Stormheim with a good mix of caster and melee mobs and made sure to pull only single mobs. I didn't want to round them up and Consecrate because I thought that might skew the test in Prot's favor. I did the test as soon as I got both Artifacts to see the least amount of Artifact Power I would have gotten for Truthguard. I killed 25 mobs as Protection and 25 as Retribution. I made sure each group of 25 contained the same number of mobs (7 casters, 7 melee, 7 elementals, and 4 bears — because I agro all bears). I only counted time spent in combat.
I went into the test with the full expectation that Ret would kill stuff faster. The only question in my mind was to quantify how much slower I'd be as Protection and then weigh the ancillary benefits of Protection against the time delta for Retribution.
But as Lee Courso might say: not so fast, my friend.
My sample size was small, but this indicates to me that your Artifact Traits play a large role in how well your spec performs.
For a final test, I engaged an elite quest mob named Stonefang. The results speak for themselves. I killed him easily as Protection in about 90 seconds. As Retribution, not only did I die on my first attempt: it took over two minutes on my second. As Prot, I could eat the Resonating Plate attacks easier. As Ret, I had to kite more often and several times I had to stop attacking to heal up.
The addition of the Artifact makes Prot a competitive leveler to Ret. Given the other perks that Prot gives you, for me, it is a easy choice.
Will you go Ret, Prot, or Holy to level? What other questions are burning in your mind as Legion's launch date draws ever nearer?


text:
Q: Why use exec to read from another file instead of importing it? This is my first post on stack overflow so excuse me in case this is a naive. I have two files, file1.py and file2.py.
file1.py just has an array(lets name it foo), which i want to include in file2. So far, I have been doing this simply by importing like this (in file2):
from file1 import foo

I stumbled upon another way to do this using exec(), but I am not sure why this would be better/faster/more efficient.
def readFromFile():
    data = dict()
    with open("file1.py") as file:
        exec(file.read(), data)
    return data['foo']

So here are my two questions:
1) Why would someone prefer the second way?
2) why is foo stored in the data dictionary but not in locals() of readFromFile

A: 1): You usually wouldn't prefer the exec way, but for local imports (in the same directory) there is not too much difference
2): Because the second argument data in exec(file.read(), data) specifies to put everything into the data dict.


SAN FRANCISCO – November 17, 2017 – Toss the confetti and sound the party horns! Videogame publisher and developer Mastiff today announced the unveiling of a brand-new website and trailer for their upcoming video game, Party Planet, a fun-packed compilation of 30 party games, which is scheduled to be released on the Nintendo Switch™ system on December 12, allowing players of all ages and skill levels to game together this holiday season.
Visit www.partyplanetgame.com to watch the new Party Planet trailer!
For the latest news, sales, giveaways, and more, please sign up to receive the all-new Mastiff Newsletter. Join in on the conversation and come party with Mastiff by following them on Twitter, Instagram and Pinterest, and by liking them on Facebook.
Review Requests: Review copies of Party Planet are now available. To request your review copy and for future communication, please use the media contact information below.


text:
The North Carolina boy's chin, "is not, fortunately, have been' sacked the deputy faces only misdemeanor charges in the case, bodyslam
to connectVideoFox News Flash, important news, Dec. 18
Fox News Flash, important news, for the Feb. 18, here. Check out what to click on Foxnews.com
A former North Carolina sheriff's deputy– who was fired from the department after a surveillance video allegedly showed him in violently and slamming an 11-year-old pupil of a secondary school, to the floor two more times, and then, dragging the boy down the hall, was arrested Tuesday on misdemeanor charges, officials said.
Warren, of Durham, who is a resource officer at Vance County Middle School, located about 45 km north-west of the city of Raleigh, north carolina, was charged with assault on a child under the age of 12, misdemeanor child abuse, and the non-fulfilment of obligations, the county prosecutor's office said. He has been placed on paid administrative leave amid an investigation into an incident reported on Thursday. Monday, the Vance County Sheriff Curtis Brame said, without letting go of the resource officer's name, and that he was no longer employed by the sheriff's office. Durham, was being held on a $10,000 bond.
THE VIDEO ALLEGEDLY SHOWS, NORTH CAROLINA'S ALTERNATE BODY-SLAMMING STUDENT-REPORT
John Miles, the grandfather of the child and the child of a pastor, said he was "quite disappointed in the law" on misdemeanor charges and claimed to be his grandson, who had a sling on his arm following the incident.
"I'm still standing today, and will you forgive this man for the loss of my grandson. I'm not happy with the misdemeanor charges," Miles told the Raleigh News & Observer. "One bad apple don't spoil the whole police force. The Sheriff Brame has done a great job on this one."
"My grandson said to me last night, 'Grandpa, what did I do to deserve this?' I said to my grandson 'You've got nothing done," he said in an interview with the Raleigh, north carolina's WTVD-TV.
In this undated department photograph shows a former Vance County sheriff's deputy, and Warren Durham. Durham faces three misdemeanor charges after allegedly beating an 11-year-old student on the floor twice, before dragging him down the hallway.
Speaking at a press conference on Tuesday, the public prosecutor's office, Mike Waters, said: "it is by the grace of God," the student, whose identity has not been released – they are not to suffer a serious injury of his office to pursue felony charges, Raleigh News & Observer reported.
"I don't think there is any sort of training or something like that, that would cause a person to act like that to an 11-year-old," Waters said. Did the child received a serious injury, we'd have a different conversation."
The State Bureau of Investigation launched a probe on Thursday after the Vance County school district, filed a complaint with the murder of an 11-year-old boy by an officer of the law," the newspaper reported. A security camera at the school, in Henderson, N. C., captured the alleged abuse.
The video, recorded on Thursday and released to local news outlets Friday, appears to be an officer of the management of a student wearing a red sweater, down a hallway of the school. It was not clear to the muted video of what was said between the officer and the student. As the video shows, the officer will not lift the student up and slam him head down into the ground. He takes the child for a second time, and threw it on the ground, before finally dragging a student by the shirt in the direction of the camera before the clip ends.
Waters said the child suffered bruising but was not hospitalized. The student reportedly did not suffer a fractured nose, broken teeth, and fractures or concussions. Under North Carolina state law, the crime of injury is defined as those that "create a risk of death, disfigurement, coma, or extreme pain."
CLICK HERE TO SEE THE ALL-NEW FOXBUSINESS.COM
Durham had worked with the department for two years and had no previous convictions or sanctions are concerned, Raleigh's WRAL-TV reported. He could face up to 90 days in jail if convicted, Waters said.
The school district will be sent via e-mail, in a statement to the Observer saying:
"We are deeply troubled by the actions that took place. School and district officials are working closely together and in close co-operation with the local authorities on this matter, in accordance with school board policies and regulations. The safety and security of our students is and will continue to be of the utmost importance to our district."
The district attorney's office, the office of the research, there was a second incident between the Head and the other a student at the school.
The Seattle area is suspected of DUI crashed into the clothing store to the left a toddler seriously injured, 10 others hurt, authorities said
California man, 40, taken into the cold-case murder — a 1-year-after-father-was approved after almost 20 years in prison
Texas man, 18, was shot at the high-school basketball game has died
to connectVideoFox News Flash, important news, Jan. 19 Fox News Flash-main news, Jan. 19 are right here. Check out what to click on Foxnews.com An 18-year-old, who was admitted to the hospital after being shot at a high school basketball game in...
Drexel University professor strip club is purchased with research grant funds will trigger a theft arrest
to connectVideoFox News Flash, important news, Jan. 19 Fox News Flash-main news, Jan. 19 are right here. Check out what to click on Foxnews.com As a former Drexel University, the department chair, and is facing criminal charges after an audit found...
Anthony Todt, the father is accused of killing a family in Florida, according to the father of the plot to kill a mother: report
to connectVideoOfficials attach the four bodies were discovered in a Florida home, the appeal of the accused on deaths Detectives in Orlando, Fla., say a suspect is in custody, and this was an isolated incident and that all affected parties are...
to connectVideoFox News Flash, important news, Jan. 19 Fox News Flash-main news, Jan. 19 are right here. Check out what to click on FoxNews.com Defense attorneys for the man accused of the murder of 20-year-old University of Iowa student, Mollie...
A Man facing execution for a Florida girl's murder, is not guilty, accomplice claims: report
to connectVideoFox News Flash, important news, Jan. 19 Fox News Flash-main news, Jan. 19 are right here. Check out what to click on FoxNews.com The two men were convicted of stabbing to death a 14-year-old girl in Florida has more than 35 years ago...
The Ex-Marine charged in murder of 16-year-old Californian girl, is called the 'online predator'
to connectVideoFox News Flash, important news, Jan. 19 Fox News Flash-main news, Jan. 19 are right here. Check out what to click on Foxnews.com A California man, who had served in the Navy, is charged with murder in the October slaying of a 16-year...
California-a woman has been found dead of a 'significant trauma' to 4 days after the friend is found hanging in the tree in the public sector
to connectVideoFox News Flash, important news, Jan. 19 Fox News Flash-main news, Jan. 19 are right here. Check out what to click on Foxnews.com The body of a California woman who had been dead "for some time", was discovered in her home...
Delbert Africa, of Philadelphia, MOVE members of a group linked to cop's death to be released after a 42-year old
to connectVideoFox News Flash, important news, Jan. 19 Fox News Flash-main news, Jan. 19 are right here. Check out what to click on Foxnews.com Delbert Orr Africa, and is a member of the radical Philadelphia group MOVE, was reported to have been...
The Baltimore state's attorney blasts police union as 'political rhetoric' after video shows man attacking officer
to connectVideoFox News Flash, important news, Jan. 19 Fox News Flash-main news, Jan. 19 are right here. Check out what to click on Foxnews.com The Baltimore state's attorney, Marilyn Mosby, took aim at the city's police union on...
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Proud to be with Ashton, after conquering the PDC tour maps: "I'm going to have my dreams to chase'
The bride would like the guests to pay the entrance fee ahead of time to get in on the exclusive vip guest list and skip the line, a cousin, said
Rashford, due to stress fracture in back, probably for months on end
Babylon had the jitters prior to a second one back for Ajax
'Miljoenenbod's PERFORMANCE at the Liverpool target denied'
Van Dyke will help the leader of Liverpool past arch-rival Manchester United
Cory Booker is not ready to confirmation in the Dems' presidential primary
Trump, climate activist Greta Thunberg of the routes set on the World Economic Forum conference in Davos
Kim Kardashian to debut "Justice Project," the trailer explains the passion for the reform of the legal system
Katharine McPhee and David Foster, poke fun at by their prenup, "You are already at 50 per cent'
With the protests against the pension reforms to keep the French tradition
Pardew starts with ADO, and with the major thuiszege to hekkensluiter his side
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Supporters create fund-raiser for Texas boy with epilepsy, uncontrollable,
7 things your OB-GYN will not tell you
More and more hospital admissions and deaths from overdose of opioids
The day of the diet: What role can diet play in type 2 diabetes?
The whole of the day, Bad for your brain, and also for your work
Bull's-eye is a nasty disease: – how do you get performance?
The Fit mom of 30, suffering from 3 heart attacks in one week: 'An enormous shock'
How to Prevent Hair Loss
Resident gives nursing home in the Netherlands on average a 7.8
'Maagverkleiningoperatie helps better to maintain weight loss'
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'Smoking can DNA harm to more than thirty years'


This entry was posted in Art and tagged 2012 blurb memories on December 23, 2012 by Mario.
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Serving Michigan's Jackson, Lenawee, Livingston, Macomb, and Washtenaw Counties
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AIA Huron Valley Guide to Architecture
Contact AIA Huron Valley
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Lecture: Mark Jarzombek
Auditorium, Art + Architecture Building, University of Michigan
Mark Jarzombek, Professor of the History and Theory of Architecture, is the Interim Dean of MIT's School of Architecture and Planning. Jarzombek works on a wide range of historical topics from the 12th century to the modern era with a particular focus on nineteenth and twentieth century aesthetics, and the history and theory of architecture.
He is one of the country's leading advocates for global history and has published several books and articles on that topic, including the ground-breaking textbook entitled A Global History of Architecture (Wiley Press, 2006) with co-author Vikram Prakash and with the noted illustrator Francis D.K. Ching. He is the sole author of Architecture of First Societies: A Global Perspective (Wiley Press, 2013), which is a sensitive synthesis of first society architecture through time and includes custom-made drawings, maps and photographs. The book builds on the latest research in archeological and anthropological knowledge while at the same time challenging some of their received perspectives.
This lecture is free and open to the public.
© AIA Huron Valley


Are you looking for a leash, which will be comfortable for your hands? This very comfortable walking dog leash for Boxer is what you need. It is lightweight and features soft padded nappa handle. It is comfortable for both you and your pet and includes a durable metal snap hook, which guarantees years of dependable use.
Leash is made of heavy-duty nylon webbing that can endure over 3,000 lbs of pressure. The heavy duty nylon webbing makes sure that your dog is secure.
You won't feel rubbing of the handle because it has soft Nappa felt.
This leash gives you a strong handle on your pet and enough room to your pet to have a quiet walk. If your doggie has an intention to do things he is not allowed to do or he wants to get to the place where he is forbidden to be, just pull the leash and your Boxer will understand that his behavior is improper.
Nickel hardware is rust and corrosion resistant. The hook can be secured in multiple places for utmost care. The metal snap hook is convenient to put in the collar and strong to hold your dog.


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Patent Allowance Extends BioCryst's Protection of Berotralstat for HAE
by David Melamed, PhD
The U.S. Patent and Trademark Office (USPTO) issued a new allowance for a patent submitted by BioCryst Pharmaceuticals for berotralstat (BCX7353), an investigational therapy to treat hereditary angioedema (HAE).
The USPTO issued a notice of allowance to BioCryst, indicating future approval. Once approved, the new "composition of matter" patent will extend BioCryst's protection over the active ingredient in berotralstat in the U.S. through October 2039.
"The extension of U.S. patent protection for berotralstat, through 2039, adds significant value to BioCryst," Jon Stonehouse, CEO of BioCryst, said in a press release. "We look forward to the U.S. approval and launch of oral, once-daily berotralstat later this year."
HAE is a rare genetic disease characterized by swelling attacks underneath the skin. These attacks are caused by excess production of a molecule called bradykinin, which is known to cause inflammation.
Berotralstat is a small molecule designed to block plasma kallikrein, a metabolic precursor to bradykinin. It is thought that blocking plasma kallikrein leads to a reduction of bradykinin levels in HAE patients.
The treatment has shown positive results in two clinical trials evaluating its safety and effectiveness in patients with type 1 or type 2 HAE, including the APeX-2 Phase 3 trial (NCT03485911) and the APeX-S Phase 2/3 trial (NCT03472040).
A total of 121 HAE patients were enrolled in the APeX-2 trial, in which participants received either a low dose (110 mg) or a high dose (150 mg) of berotralstat, or a placebo.
Results showed that both doses reduced HAE attacks in patients over a 24 week period by 30% (low dose) and 44% (high dose) compared to the placebo.
The study also suggested that attack severity may be reduced by berotralstat, as the monthly rate use of on-demand medication to treat attacks was reduced by 46.3% in the low dose group and 53.6% in the high dose group.
In the APeX-S trial, the majority of patients taking berotralstat did not experience swelling attacks during the first six months of the study.
The treatment was safe and well-tolerated in patients in both trials.
These positive clinical trial results led BioCryst to submit applications for the approval of berotralstat to regulatory agencies in the U.S., European Union, and Japan.
In the U.S., BioCryst submitted a new drug application, which is under review by the U.S. Food and Drug Administration. The application has a Prescription Drug User Fee Act action date of Dec. 3, meaning that a decision will be made by that date.
In Europe, the Committee for Medicinal Products for Human Use is reviewing berotralstat and is expected to make a decision before April 2021. The Japanese Pharmaceuticals and Medical Devices Agency also is reviewing an application for berotralstat, with a decision expected in the second half of this year.
David Melamed, PhD
David earned a PhD in Biological Sciences from Columbia University in New York, NY, where he studied how Drosophila ovarian adult stem cells respond to cell signaling pathway manipulations. This work helped to redefine the organizational principles underlying adult stem cell growth models. He is currently a Science Writer, as part of the BioNews Services writing team.
Patricia Silva, PhD
Patrícia holds her PhD in Medical Microbiology and Infectious Diseases from the Leiden University Medical Center in Leiden, The Netherlands. She has studied Applied Biology at Universidade do Minho and was a postdoctoral research fellow at Instituto de Medicina Molecular in Lisbon, Portugal. Her work has been focused on molecular genetic traits of infectious agents such as viruses and parasites.
Tagged BCX7353, berotralstat, BioCryst, FDA, notice of allowance, patent, USPTO.
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ENO Drip Strips. Not much can ruin a good hang, but the rain sure can dampen the mood.
Keep those annoying drips at bay with ENO Drip Strips. Acting as mini barriers to redirect rogue water streams away from your hammock, the Drip Strip attaches to any ENO Hammock Suspension System with a simple place and clip.
Combined with an ENO Rain Tarp, they will keep your hammock dry and your spirits high. Eagles Nest Outfitters.


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The Coral Room, London: putting the class in co-working
PUBLISHED:	 17:17, Tuesday, 6 March 2018 | UPDATED:	 11:43, Thursday, 2 May 2019
By Tom Hayward
News Correspondent
If you imagined a co-working space, you would be forgiven for picturing openplan areas of red brick, exposed chrome ducting and upcycled furniture, inhabited by plaid-clad millennials hunched over Mac- Books and drawing boards.
But in The Bloomsbury Club, in the heart of central London, is The Coral Room – an eye-catching cocktail bar that is aiming to exploit a niche in the market and bring a touch of class to the traditional notion of shared office space.
In what is a burgeoning and fiercely competitive self-employed market, getting a lead on your competitors can make all the difference. So, what better way to impress a client or win a pitch than taking them to one of the capital's most exclusive co-working-friendly venues?
"The Coral Room is unique because of the sense of luxury we provide. Our high levels of service would certainly be one of our unique selling points compared with the traditional co-working space model," sales and marketing manager Joshua Craddock tells Modern Work in the art deco-inspired bar.
This is a fancy co-working space
"The Coral Room is already frequently used by freelance workers, entrepreneurs and local businesses for small meetings already. It's a market we're actively targeting and currently we have about 100 visitors every day who use our venue for various work-related purposes.
"During the day, the space is largely used by local businesspeople; then in the evening, with a slick cocktail bar, the world's most extensive English sparkling wine offering and occasional live music sets, The Coral Room comes into its own.
"The interior design is world-class, the environment is impressive, and the location is easily accessible, which makes it a great place to impress or win clients.
"We're trying to do something different and the venue is perfectly conducive to a work/ play daytime/night-time dynamic. You don't have to be a member; you can just come in, and we find that openness brings us a lot of success.
"This is definitely an audience we are keen to continue to attract and, whilst the bar isn't anti-suits like some other venues, everyone is welcome to enjoy our luxury setting and five-star service."
This is a fancy place in Bloomsbury
Designed by the Martin Brudnizki Design Studio – the inspiration behind The Beekman Hotel in New York and Scarfes Bar in London – the venue is striking, with sleek furniture and impressive chandeliers dominating a room of coral walls and polished parquet flooring.
Despite its grandeur, The Coral Room places emphasis on supporting local entrepreneurs and last year commissioned local artist Luke Edward Hall to produce a series of works that add a homely feel.
"The space is unique and exclusive, yet sociable. There is an abundance of power sockets, complimentary Wi-fi, attentive service and plenty of luxury desk space," Craddock continues.
The venue has only been operating since November and due to its unique model, is operating a trial and error approach which has, thus far, seen its audience and reach increase at a rapid rate.
At present, this space is used solely for work, but as The Coral Room identifies its users and their needs, they are keen to host events and become involved in the wider self-employed community.
"Having opened in November 2017 we're new, so it's hard to identify challenges at this stage, but we will officially launch into the London scene in April, which is really exciting."
It was recently described by The Telegraph (Luxury) as "an impressive, genuinely beautiful room, that is simultaneously reminiscent of 1920s decadence and Miami art deco".
But as has been The Coral Room's mantra since its inception: "Come and see for yourself."
Will tech help or hinder freelancing?


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This infographic provides tips on how to look for a job in Canada.
Some strategies for looking for a job in Canada include networking, conducting information interviews, using social media and volunteering.
You can also find more tips on finding work in our Tips for Finding Work Before you Arrive article.
What career strategies should I consider? – Tips and advice on career planning and job search as a newcomer in Ontario. From Settlement.Org.
Job Bank - A resource with job listings, labour market information and tips for job seekers. From the Government of Canada.


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Investcorp acquires North American water meter assets of Schlumberger
Investcorp today announced that it has acquired, through an affiliate, substantially all of the North American water meter assets of Schlumberger.
NEW YORK, Nov. 12, 2001 — Investcorp today announced that it has acquired, through an affiliate, substantially all of the North American water meter assets of Schlumberger.
The transaction involves the equity ownership and continuing leadership of the senior management of Schlumberger's North American water business. The new company will be called Neptune Technology Group.
Founded in 1886 as Thomson Meter Company, and in 1892 renamed as the Neptune Meter Company, Neptune Technology Group is a leader in the North American water works industry. Through its network of direct sales personnel and distributors, the company provides water utilities with a comprehensive product offering of water meters and advanced meter reading systems. Neptune is headquartered in Tallassee, Alabama, where it also operates its principal manufacturing facility.
In a related transaction announced today, an affiliate of Investcorp also acquired a one-third interest in DAP Technologies, Ltd. from Schlumberger Canada Limited. DAP is a designer and manufacturer of rugged handheld computers for use in applications such as utility meter reading, as well as a variety of industrial field related uses. In addition, Investcorp received an option from certain other stockholders of DAP to purchase an additional one-third interest in DAP Technologies. The interest in DAP will be owned by a subsidiary of Neptune Technology Group Inc.
About Neptune Technology Group Inc.
Neptune offers metering products and meter reading systems to water utilities throughout North America. The market sectors in which the company participates are residential, commercial and industrial water metering, and meter reading systems.
About Investcorp
Investcorp is a global investment group with offices in New York, London and Bahrain. Since 1982, it has completed transactions in North America and Western Europe, with a total value of approximately $19 billion. Additional information may be found at http://www.Investcorp.com.
Malaysian water utility cuts non-revenue water by one-third with remote monitoring


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Division of Chemical Information Sponsors Spring 2015
The American Chemical Society Division of Chemical Information is very fortunate to receive generous financial support from our sponsors. Their support allows us to maintain the high quality of the Division's programming and to promote communication between members at social functions at the ACS spring 2015 National Meeting in Denver, CO, and to support other divisional activities during the year, including scholarships to graduate students in chemical Information.
The Division gratefully acknowledges contributions from the following sponsors:
Gold: ACS Publications
Silver:
Bio-Rad Laboratories
Bronze: Journal of Chemical Information and Modeling
Journal of Cheminformatics (Springer)
Contributors: AAAS/Science
Thieme Chemistry
Opportunities are available to sponsor Division of Chemical Information events, speakers, and material. Our sponsors are acknowledged on the CINF web site, in the Chemical Information Bulletin, on printed meeting materials, and at any events for which we use your contribution. For more information please review the sponsorship brochure at http://www.acscinf.org/PDF/CINF_Sponsorship_Brochure.pdf. Please feel free to contact me if you would like more information about supporting CINF.
Chair, Fundraising Committee
Email: sponsorship@acscinf.org
The ACS CINF Division is a non-profit tax-exempt organization with taxpayer ID no. 52-6054220.
PerkinElmer News
PerkinElmer is excited to be a part of the 249th American Chemical Society (ACS) Meeting, from March 22-26 in Denver, Colorado! Scientists who design and synthesize compounds and measure and analyze their chemical and biological properties are an integral part of making our world a healthier and safer place. The informatics division of PerkinElmer has a host of products that help scientists easily record data in an electronic lab notebook, analyze and visualize their data in Spotfire, draw chemical reactions, analyze data with statistics, collaborate with colleagues in the cloud, and work with outside collaborators like CROs. We are looking forward to showcasing our new products at our booth #1106, as well as during a talk. Our talk is "Mining Electronic Lab Notebooks for Synthetic Needles", presented by Josh Bishop, Ph.D., on Sunday March, 22, 2015 from 11:20 AM - 11:45 AM in Room 110 Convention Center.
Here are a few of the products that PerkinElmer will be showcasing:
ChemDraw + SciFinder
This year, ChemDraw celebrates its 30th anniversary! It is the drawing tool of choice for chemists and biologists to help create publication-ready drawings for use in electronic lab notebooks, databases and publications. Now you can search the SciFinder database directly from ChemDraw without worrying about cutting and pasting. As well as the desktop version we will also be showcasing ChemDraw for iPad and the new JavaScript sketcher ChemDraw Direct.
Collaborating in the Cloud--Elements
Come by booth #1106 to preview Elements - our cloud-based collaboration platform. Join us as we demonstrate how to plan and capture experiments, draw chemical reactions with ChemDraw, upload images, organize data and share research with colleagues. Check out a preview video here.
Spotfire for Scientists
Come and see how the TIBCO Spotfire data visualization and analysis platform (example pictured above) can help you achieve insights faster. Spotfire is a dynamic, collaborative tool that assimilates data such as chemical structures, text, numbers, images, chemical properties and biological assays from multiple sources. It empowers scientists to perform complex analyses and create easy-to-use visual dashboards. Josh Bishop, Ph.D. will present a talk about optimizing reaction conditions by using ENotebook-based screening tools, followed by queries of results with Spotfire, Datalytix and Lead Discovery on Sunday, March, 22, 2015 from 11:20 AM - 11:45 AM at Room 110 - Colorado Convention Center
PerkinElmer E-Notebook
Come by our booth # 1106 to see how our E-Notebook has helped chemists and biologists, across multiple industries. Learn how to quickly record experiments, draw chemical reactions with ChemDraw, upload documents, integrate with Microsoft Office, protect intellectual property, organize data, and share research with colleagues or external collaborators such as CROs.
Text mining for chemistry and the CHEMDNER track
A recently published supplement of Journal of Cheminformatics (http://bit.ly/CHEMDNER) describes the outcome of the first community challenge task on chemical natural language processing, carried out as part of the BioCreative initiative (www.biocreative.org). The supplement contains an overview of the results obtained for indexing articles with chemical compounds and identifying automatically the exact mentions of chemicals in the text. The methods, resources and features used as well as details on the manually labeled text corpus used are described in this supplement. Thirteen systems description articles out of the 27 participating teams provide additional characteristics on the cutting-edge methodology used for recognizing chemical entities in text, as well as further improvements over the initially implemented strategies.
ChemTexts: First articles published
The first textbook journal worldwide recently published the first articles. All articles are free to access in 2015 and 2016. ChemTexts (http://bit.ly/chemtexts) imparts contemporary knowledge in all subdivisions of chemistry to students at an exceptionally high didactic level. ChemTexts can be used by students for learning, by lecturers for teaching, or by researchers and professionals as a recap of essential knowledge. On the pedagogical level, the journal primarily supports bachelor and master programs, but material at higher level is also considered. Typically, each text consists of a self-consistent treatment of a topic which could be part of a textbook. Beyond informative illustrations, the texts may also include supplementary material such as animated presentations or videos.
Chemistry@Springer: LinkedIn group welcomed 2000th member
This group was started in January 2012 (http://bit.ly/SpringerChem) and now has grown beyond a membership of 2000 scientists and professionals. Members can talk to Springer chemistry editors and to other members about their work and find out everything they want to know about scientific publishing. In addition, the group provides information about conferences, latest publications and everything else of interest about chemistry at Springer.
OnChemistry: re-launched blog for Chemistry Central
Springer's platform for open access content in chemistry has recently relaunched its blog (http://bit.ly/OnChemistry). The OnChemistry blog showcases the high-quality and thought-provoking open access research published across Springer's chemistry portfolio. As well as writing about the published research, the blog is also a place to read about open access developments, conferences, awards and highlights from the field. Most of the posts are written by staff, but readers also hear from Chemistry Central Editorial Board Members and a variety of guest bloggers.
Steffen Pauly, Editorial Director Chemistry
ORCID iD: http://orcid.org/0000-0001-9768-9315
New look for chemistry journals SYNTHESIS and SYNLETT
The international chemistry journals SYNTHESIS and SYNLETT, published by Thieme Publishing Group, feature a brand new design. Both journals appear with a new cover design and a more reader-friendly, clear layout.
The new design updates the look of SYNTHESIS and SYNLETT, making them visually more appealing. Both the printed journals and the online versions feature color-coded sections to help readers find articles and topics of interest even more quickly. The tables of contents include larger graphical abstracts which are repeated at the beginning of the respective articles. Graphics and tables within the articles are highlighted more clearly. Both journals also receive modern covers with new and distinctive title logos. Each issue highlights one scientific article with an associated graphic on the cover.
"We want to deliver our content in a better, more consistent and easy-to-navigate way to improve the reading experience for our users," says Susanne Haak, Managing Editor of the Thieme Chemistry journals. "With the redesign we are also taking into account that nowadays most of our subscribers prefer reading our journals electronically. The new layout greatly improves online readability, for example through a header with the journal logo at the top of each article for better orientation."
The first printed issues of SYNTHESIS and SYNLETT to feature the new design were published in January 2015.
SYNTHESIS and SYNLETT, both published in English, report the latest scientific developments in synthetic chemistry. The articles are selected, reviewed, and edited by an internationally renowned editorial board to guarantee chemists access to the latest research insights in their respective fields. The subscription journals are published semimonthly in printed and electronic format by Thieme Publishing Group. Articles and primary data can be accessed online at http://www.thieme-connect.de/ejournals, most of them prior to print publication. For more information and how to register for an institutional trial access visit: www.thieme.com/chemistry-journals.
About Thieme
Thieme Publishing Group is a medical and scientific publishing house employing more than 900 staff and maintaining offices in seven cities, including New York, Delhi, Rio and Stuttgart. Founded in 1886, the Thieme name has become synonymous with high quality and excellence in online and print publishing. Thieme publishes 150 peer-reviewed journals and more than 450 new books annually. The company also has a rapidly growing array of web-based products in medicine and science. Popular online products include Thieme E-Journals and the Thieme Electronic Book Library, which are accessible via www.thieme-connect.com, Thieme's platform for electronic products.
‹ In Memory of Paul von Ragué Schleyer up Technical Program ›


Home » Free » What makes you happy?
Sometimes life just seems to move forward relentlessly and we don't take the time to stop and reflect on our different feelings and emotions in different situations.
What makes you happy? Do you ever stop to think about it? Could you make a list of 10 things that make you smile, laugh or feel really good? Can you make more opportunity for these things in your life?
That's a lot of questions, but I really think that we tend to move through life without enough appreciation of the things that make us tick and feel good.
I set myself this challenge today and tried to think outside the box and really see what makes me tick. I will share just a few things of what I came up with. Even making this list made me smile, so that was my little bit of positivity for today.
People I love. Family is precious and good friends are to be treasured.
Dogs. I always seemed to have a good affinity with dogs and they give me a feeling of warmth and happiness.
Colors. I feel happy when surrounded by lovely strong colors; like sunrises, autumn leaves, patchwork quilts, colorful clothes, glorious paints etc.
Texture. I am not a great shopper for clothes, but when I do go into a clothes shop I absolutely can't resist touching and feeling anything that is soft and fluffy. My hands take on a life of their own.
Music. Particularly music from long ago that evokes memories. Be it the jazz or big-band music that my Dad loves to the music of the 1970's when I had my first experiences of popular music, to country and light classical.
Learning something new. Taking on a challenge is great!
Seeing other people's accomplishments. There are lots of stories and videos out there about people beating the odds, achieving personal goals and successes for themselves and others. These stories are often very emotional and most of us get a good feeling from seeing another person's achievements and successes, particularly if they come from a background where they had to overcome obstacles to reach their goals. I love a trier and believe that we are all more able than we think we are at times.
Traveling and seeing new places.
Reading. Particularly mysteries and "Who done its".
Taking photographs of the birds in my garden.
There is lots more, but I'll be mindful of your time!
What would be on your list of things that make you feel good? If you would like to share, I would love to hear.


Astronomers encounter a series of ethical dilemmas during their careers that need to be resolved correctly if the integrity of the field is to be preserved. These issues may arise while teaching, conducting research, or leading large, long-term projects or missions. The goal of this graduate seminar is to sharpen ethical reasoning, knowledge, awareness and commitment by providing a fundamental background in responsible conduct as a scientist. Among the topics covered: (1) Mentoring, (2) Data management, (3) Peer review, (4) Authorship, (5) Intellectual property, (6) Conflicts of interest and commitment, (7) Research misconduct, (8) Dual use technologies, and (9) Environmental and Cultural Impact.
Participants should expect weekly reading and writing assignments, such as the analysis and development of case studies, and plenty of opportunity for discussion.


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Home Science Samsung presented its new Galaxy S21 line: New design, no charger and...
Samsung presented its new Galaxy S21 line: New design, no charger and less expensive
After a year marked by the effects of the coronavirus pandemic, where the declines in smartphone sales were noticeable especially in top-of-the-line equipment, Samsung made its great presentation of the year with a great guide: make it clear that your next line Galaxy S21 It will not be a mere annual cosmetic renewal.
Broadly speaking, during the traditional Unpacked event, the South Korean company presented three models: the Galaxy S21, S21 More and the S21 Ultra.
Starting, these new smartphones have a design that will modify the back of the device. The cameras will be grouped in a new rather eye-catching module in the upper left corner.
Another change will be brewing in the two least expensive models, the S21 and the S21 Plus, since they will have a flat 2X Dynamic AMOLED screen, while the S21 Ultra will be the one that will maintain the curved display that had characterized this line. As for the screen, all models will be able to reach a refresh rate of 120HZ, although only the S21 Ultra has a QHD + resolution compared to the FULL HD + panels of its smaller brothers. And on the blessed inches, the S21 is 6.2, the Plus model comes in at 6.7, and the Ultra is set at 6.8.
Another change involves the new Exynos 2100 processor, presented this week by Samsung in the framework of CES 2021, although some areas of the world, such as the United States, will make use of Qualcomm's Snapdragon 888 processor in the basic model. Obviously all the architecture will also be built based on the new 5G technologies.
In terms of storage, say goodbye to microSD, since its slot was eliminated while the internal storage will have configurations between 128 and 512 GB.
The cameras also include improvements and coincidences with each other, such as recording video in 8K at 24 frames per second, although the Ultra model is the one that has the photographic variations that make it stand out from the other models. That includes a 108 megapixel main sensor, two telephoto lenses with optical zoom, and the following base features:
Galaxy S21 & S21 Plus: 12MP ultra wide angle lens | Telephoto: 64MP with 3X Hybrid Zoom | Wide Angle: 12MP Front: 10MP
Galaxy S21 Ultra: 108MP Ultra wide angle lens | 1: 10MP telephoto lens with 3X optical zoom | Telephoto 2: 10MP with 10x optical zoom | Wide Angle: 12MP | Front: 40MP
Before finishing, another striking change lies in the fact that these computers do not have a charger, so they follow the trend already imposed by Apple to eliminate these elements under the argument of reusing the cables that users already have in their homes. Do you need a new one? Well, they will have to buy it separately.
The batteries of the equipment, in that sense, range from 4,000 mAh in the basic model to 5,000 mAh in the Ultra model, the same that is also noted with the fact that it is the first Galaxy S model that is compatible with the S -Pen that until now had been in the Note models. Although this pencil is not included and must also be purchased separately.
The last eye-catching item is cost related, as the Galaxy S21 family will be less expensive. The S21 and S21 Plus will cost $ 800 and $ 1000 respectively, while the Ultra model will cost $ 1200. That is, each model will cost $ 200 less than the prices of its predecessors.
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Grain Legume Genetics Physiology Research: Pullman, WA
ARS Home » Pacific West Area » Pullman, Washington » Grain Legume Genetics Physiology Research » Research » Publications at this Location » Publication #218530
Title: Genotyping with Real-time PCR Reveals Recessive Epistasis Between Independent QTL Conferring Resistance to Common Bacterial Blight in Dry Bean
Vandemark, George
FOURIE, DIEDRE
Miklas, Phillip - Phil
Submitted to: Journal of Theoretical and Applied Genetics
Publication Acceptance Date: 5/5/2008
Citation: Vandemark, G.J., Fourie, D., Miklas, P.N. 2008. Genotyping with Real-time PCR Reveals Recessive Epistasis Between Independent QTL Conferring Resistance to Common Bacterial Blight in Dry Bean. Journal of Theoretical and Applied Genetics.117:513-522.
Interpretive Summary: Molecular markers are DNA sequences that can be useful for selecting plants with desired attributes for traits that are difficult to evaluate, such as disease resistance. However, many traits are not controlled by a single gene, but rather by an interaction between several genes, each of which may have different amounts of influence on trait expression. One of the most severe diseases of bean is a leaf and pod disease caused common bacterial blight (CBB). Up to 22 different genes have been implicated in the expression of resistance in bean to CBB. Historically, molecular markers associated with these resistance genes have only been able to determine if the gene of interest is present, but have not been able to distinguish plants with one copy of the gene from plants with two copies of the gene. Breeders need to be able to identify plants that have two copies of a gene of interest in order to assure that a variety produced from these plants uniformly expresses the trait. In addition, previously available molecular markers have not been useful for determining how different genes interact to confer resistance to CBB. Two important genes for resistance to CBB are referred to as BC420 and SU91. This paper describes the development of "real-time fluorescent PCR" assays that were used to determining whether plants have zero, one, or two copies of both BC420 and SU91 and to establish how these two genes interact to confer resistance to CBB. We observed the following relationships between these two genes: 1. Plants with no copies of SU91 are susceptible to CBB even if they have two copies of BC420; 2. Plants that have no copies of BC420 but at least one copy of SU91 express moderate disease resistance, and 3. The highest level of resistance occurs in plants that have at least one copy of both BC420 and SU91. These results indicate that bean breeders must pick plants that have copies of both of these genes in order to realize the highest levels of resistance possible. In addition, the PCR assay can be used to identify plants with desired gene combinations as seedlings. This will result in savings of thousands of dollars per breeding cycle in labor and facilities costs. These results will also make it possible to develop resistant varieties much faster than could be done using previously available molecular markers.
Technical Abstract: Resistance to common bacterial blight in common bean is a complex trait that is quantitatively inherited. Combining QTL is the current strategy for improving resistance in, but interactions among different QTL are unknown. We examined the interaction between two independent QTL present in dry bean breeding line XAN 159. The QTL were studied in a near isogenic population consisting of 120 BC6:F2 plants. Each BC6:F2 plant was evaluated for disease reaction at several time points after pathogen inoculation and the dominant SCAR markers linked with QTL on linkage groups B6 (BC420~QTL) and B8 (SU91~QTL) were interpreted as codominant markers using real time PCR assays. This enabled assignment of BC6F2 plants to all nine possible genotypes. Reaction to CBB in BC6:F2 plants was characterized by an epistatic interaction between BC420 and SU91 such that: i) the expression of BC420 was epistatically suppressed by a homozygous recessive su91//su91 genotype; ii) SU91//SU91 and SU91//su91 genotypes conditioned an intermediate disease reaction when homozygous recessive for bc420//bc420; and iii) the highest level of disease resistance was conferred by genotypes with at least a single copy of both QTL (BC420//-; SU91//-). Segregation for resistance among BC6F3 plants derived from BC6F2 plants that were heterozygous for both QTL did not deviate significantly from expected ratios of 9 resistant: 3 moderately resistant: 4 susceptible. This is consistent with a duplicate recessive epistatic model of inheritance between two loci. These results indicate breeders will realize greatest gains in resistance to CBB by selecting breeding materials that are fixed for both QTL. This is a first report of a qualitative digenic model of inheritance discerning an interaction between two QTL conditioning disease resistance in plants.


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Peggie is has been in the Orthodontics industry since 1992. Unfortunately, it takes about that long to become an expert at dealing with insurance companies. But we can't thank her enough for getting our patients the most out of their insurance plans. Peggie grew up in a family with nine kids. If that sounds like a lot wait till you hear this…she has 94 immediate family members. Peggie learned at an early age how to navigate sibling rivalry. Since Hough Orthodontics is a family business, those skills sometimes come in handy ?. Peggie spends her free time with her three grandkids, traveling to the beach and helping others.


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After Man's Death, Widow and Daughter Learn They Aren't Entitled to His Inheritance – Story of the Day
After her father's death, Julia rummaged through his office and discovered his will, which gave their house to someone named John. She and her mother were shocked. They called their lawyer, who introduced them to John, and they all found out the outrageous secret Julia's father had kept.
Julia rearranged some of the papers on her dad's office desk a few days after the funeral. She and her mother needed to pack some of his stuff and clean everything up. Her father always kept essential papers in his office, and Julia needed to locate them so her mom wouldn't have to worry about anything later on.
However, as she passed papers and envelopes from hand to hand, she saw something odd. One particular packet came from a local law firm in Fort Lauderdale, Florida. But they lived in Miami. It was only about an hour away, but Julia frowned. Something in her gut told her to open it and check things out.
She ripped the seal and discovered her father's will. She was shocked. As far as they knew, he hadn't had time to make one. He was healthy, and his heart attack had been sudden. Julia skimmed through the lengthy legal jargon until she reached a specific part, and her jaw dropped.
"Mom! Mom!"
"Jules, why are you yelling?" her mother appeared in the doorway and entered the office.
"Look!" Julie exclaimed again and raised the papers in her hands.
"Wait, let me put my glasses," her mother, Mrs. Moss, said as she put her reading glasses on and grabbed the papers. "Oh my."
"Mom, did you know about this?"
"No, honey. I had no idea. What does it say?" Mrs. Moss asked her daughter.
"It says the house and everything else goes to some man named John Serrano. Who is that?" Julia exclaimed, worried. She couldn't believe her father had left his wife with nothing.
"I don't know, Julia. This is so strange. Are you sure it's legit?" Mrs. Moss replied, looking up at her daughter with concern on her face.
"I don't know that either. But let's call the law firm," Julia said, trying to remain calm.
She googled the law firm and got their phone number. After asking around, they discovered her father's lawyer was a man named Isaac Abrams. They connected her to his private phone line, and he offered to meet with them the following day.
Julia and Mrs. Moss got in their car the following morning and made the trip to Fort Lauderdale, still not understanding why Mr. Moss had done something like this. During the drive to the lawyer's office, many things went through Julia's mind. Why Fort Lauderdale? Who was this John Serrano? Why didn't Mom know anything about him? What was her father hiding?
Luckily, they arrived soon enough and entered the law firm. They were escorted to Mr. Abrams' office and told to wait a few minutes. Finally, the lawyer appeared with another man in tow. Julia knew immediately that it had to be John.
He was around her age, or maybe a few years old than her. Her intuition told her that John had to be someone important. Her father did this for a specific reason but clearly couldn't bear to tell them.
"Mrs. Moss and Ms. Moss, I assume? It's delightful to meet you. I'm Isaac Abrams," the lawyer introduced himself, extending his hand to shake theirs. "And you might have guessed that this is John Serrano. The man whose name appears on Mr. Moss's will."
"Who are you? Why are you in the will?" Julia demanded. It didn't matter what her intuition said. She was still mad that her mother would be out on the streets because of this man.
"Who am I? Who are you?" John replied, frowning and almost getting angry.
"Please, everyone, calm down. Let's take a seat. This is a complicated matter. I was going to call you a few days later to give you time to mourn after the funeral, but you called me first, so here we are," Mr. Abrams began. "Your father kept a secret from you all."
"Your father?" John asked in a whisper and looked at Julia. She stared back at him with her brows down.
"Yes, he's my father," Julia replied.
"Mr. Moss was also John's father, Ms. Moss," Mr. Abrams revealed.
Julia's mouth dropped open. Her mother didn't know what to say, but she stared back and forth between John and Julia. John looked confused, and the lawyer spoke up again.
"Mr. Moss gave me the task of explaining this because he couldn't do it himself. A few years ago, he reconnected with John after finding him on social media, correct?" Mr. Abrams checked with John, who nodded. "Do you want to continue the story, John?"
"Well, I mean… there's not much to say. He and I started meeting a few times a month and stuff. But he never told me about you. I thought he didn't have any other kids. I guess he didn't tell you about me either, huh?" John said sheepishly.
"No, he didn't," Julia whispered. In her gut, she had known that John was probably family, but she couldn't understand why her father had kept such a secret.
"Well, as Mr. Moss told me, he was ashamed of his past. Apparently, he broke up with John's mother after discovering her pregnancy. Years later, he met Mrs. Moss and started a family with her. When he reconnected with John, he wanted to make up for all those years he wasn't a father to him and decided to give him everything," Mr. Abrams continued.
Julia and her mother nodded, although they were still flabbergasted. "I guess we should move out of the house as soon as possible," Mrs. Moss said, resigned.
"No, Mom. It's your house," Julia countered.
"Not according to those documents. Your father owned it before we got married. I don't know if I have any rights to it," the older woman continued.
Finally, John chimed in. "I have no desire to kick you out of your house. You can keep it. I don't need it. I don't want to move to Miami either. My job is here."
"Thank you," Julia said, breathing a huge sigh of relief. She was worried about her mother and where she would live, but John's attitude was a considerable weight off her shoulders.
They continued talking, and Mr. Abrams agreed to help them arrange everything. John also suggested splitting the money between all of them. "I didn't contact him for money or anything. I'm perfectly fine. I just wanted to get to know him," he explained.
They finished the meeting, and John gave Julia his phone number. "In case you ever need it," he said and left the building.
A few days later, all pertinent paperwork was arranged, and Julia thought she could forget about this whole ordeal. But she called John out of the blue and chatted with him. He was married and had two kids, while Julia had two cats.
They called each other at least once a week, and Julia invited him to meet the extended family. Soon enough, he became one of the most important people in her life, and she spoiled his children terribly.
In her heart, she was still mad at their father because they had missed years of knowing each other, but he was probably scared of what they would think. He was human, and errors are a part of life.
Everyone makes mistakes. We all blunder once in a while. The important thing is to learn from it and change for the better. Mr. Moss didn't get a chance to introduce John to his family, but he made it up to him as best he could.
A stranger can become an important part of your life. Julia and John eventually thought of each other as siblings, although they were not sure of each other at first.


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GSMA Announces Launch of Disaster Response Innovation Fund
GSMA Calls for Applications to Develop Services to Improve Communications for Humanitarian Crises
September 07, 2017 03:00 AM Eastern Daylight Time
LONDON--(BUSINESS WIRE)--The GSMA today announced the launch of its Disaster Response Innovation Fund to spur development of mobile technology solutions to assist and empower people and communities affected by humanitarian emergencies, and to strengthen disaster prevention, preparedness and response. The Fund is backed by the UK Department for International Development (DFID) and supported by the GSMA and its members.
"Mobile technology is a vital tool to help those impacted by natural disasters and other humanitarian emergencies," said John Giusti, the GSMA's Chief Regulatory Officer, GSMA. "In support of the United Nations Sustainable Development Goals, the GSMA has launched the Disaster Response Innovation Fund to extend the impact of mobile in helping build resilient infrastructure and making communities inclusive, safe, and sustainable."
In times of crisis and disaster, mobile networks facilitate critical communication between humanitarian agencies, affected populations and the international community. This has been evidenced in the aftermath of the 2015 Nepal earthquake, the ongoing displacement crisis in the Middle East and Europe, and many other recent events. The Disaster Response Innovation Fund will stimulate the development of mobile-based solutions that deliver a positive impact on people affected by disasters and crises, helping to reduce risk, save lives, ease suffering and promote recovery.
The Fund is open to applicants delivering impact in Sub-Saharan Africa, Asia Pacific, Latin America, the Middle East and/or North Africa. Applications must represent a collaboration consisting of two or more mobile network operators, NGOs, humanitarian agencies, emergency/environmental bodies and/or private sector companies. For instance, potential applications could include an Internet of Things solution for triggering early warning system alerts or an open-source mobile-based platform for sharing humanitarian information.
Funding of up to £300,000 per project is available and applicants should be either seed projects to test new products or services, or market validation projects to replicate proven products or services. Applications will be assessed through a two-stage application process: concept notes should be submitted between 7 September and 13 October 2017 and then selected applicants will be asked to submit a full proposal by 1 December 2017. The selection of projects to be funded will be finalised in late March 2018.
For detailed information and requirements please visit: www.gsma.com/mobilefordevelopment/programmes/disaster-response/innovation-fund.
About the GSMA
The GSMA represents the interests of mobile operators worldwide, uniting nearly 800 operators with more than 300 companies in the broader mobile ecosystem, including handset and device makers, software companies, equipment providers and internet companies, as well as organisations in adjacent industry sectors. The GSMA also produces industry-leading events such as Mobile World Congress, Mobile World Congress Shanghai, Mobile World Congress Americas and the Mobile 360 Series of conferences.
For more information, please visit the GSMA corporate website at www.gsma.com. Follow the GSMA on Twitter: @GSMA.
For the GSMA
Clare Fenny
CFenny@webershandwick.com
GSMA Press Office
pressoffice@gsma.com