text:
Q: How to write a SourceControl Add-in for VS Express edition As you all know Visual Studio Express edition do not support Source Control Integration and Add in
As it is obvious there is a feature which allows VS tointegrate with any kind of source control. So I'm using VS express for myself (in home, and for my presonal Project and want to use a source control for my projects) So what should I Do
Currently I'm using SVN and by Command Prompt using svn, but I want to create an Add-In for VS Express edition which works with VS Express.
Any help will Appriciate.

Update : An example for doing this is to write an application which run beside of VS and by refactoring find the Items and make them capable to work with a sourcecontrol inside of VS express
your solution may be completely different

A: As Sam said, you can't write an Add-on.  In my opinion, the best add-in for the full Visual Studio is AnkhSVN and they have not been able to create one either.
So I would recommend looking at Tortoise SVN instead.  It is a complete, mature and Free GUI SVN client, implemented as a Windows Explorer extension.  If you can't integrate into Visual Studio Express, this is the next best thing.

Microsoft's Dan Fernandez from the Visual Studio team does discuss on his blog how TestDriven.NET managed to work around the restrictions in the Express Editions.
I recommend against trying this for practical and ethical reasons, but the information is out there, so this answer would not be complete without it.

A: I don't think you can as the express editions don't support Add-ins.  See this question for some more details


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FanDuel Surges To The Front Of The Michigan Online Sportsbook Pack In First Full Month
FanDuel, BetMGM, and DraftKings each did well in February in terms of betting handle in Michigan, although only one turned a profit.
When Michigan online sportsbooks first opened and released the first 10 days' worth of numbers last month, it appeared there were a Big Four of operators.
Now, with February's release, it's more like a Big Three Plus One, as FanDuel Online Sportsbook, BetMGM Sportsbook, and DraftKings Sportsbook pulled away from Barstool Sportsbook in terms of total handle for the month.
FanDuel paced the field with over $87.2 million in bets, BetMGM came in a strong second with $75.7 million, and DraftKings took the show with $73 million.
Barstool — which some touted as not only big competition to the above, but perhaps the once and future king of Michigan sportsbooks — brought in "only" $40.3 million in handle.
After those four sportsbooks, the pickings started getting relatively slim, with PointsBet Sportsbook booking just shy of $7 million in action, FOX Bet Sportsbook $5.8 million, Caesars Sportsbook $5.6 million, BetRivers Sportsbook $3.6 million, Twin Spires $1.9 million, WynnBET Sportsbook $1.4 million, Golden Nugget Sportsbook $498,000, and Four Winds bringing a little over $12,000 to the table.
Overall, total handle for the month was a robust $301.9 million.
BetMGM books a profit
Of course, handle is one thing, but gross betting receipts are another, and the sportsbooks totaled a little over $9.4 million in that regard, for a flimsy hold of 3%. Part of the reason for this may be related to the Tampa Bay Buccaneers' upset of the Kansas City Chiefs in the Super Bowl, which featured University of Michigan alum Tom Brady leading the Bucs to victory.
Even worse for the sportsbooks: Once promotional money is taken into account, the adjusted gross betting receipts for the month took a turn to the red, with the sportsbooks taking a collective $10.8 million bath.
Individually, the most profitable sportsbook for the month of February, after promotional money, was BetMGM, with a relatively healthy $2.4 million profit.
After that? Not pretty, with William Hill being the only other book to post a profit, and it was a paltry $16,651 adjusted.
Overall, the online sportsbooks paid a meager $142,239.58 in taxes, not quite the budget panacea many had hoped for. Alas, Brady isn't playing in March Madness — but the top-seeded University of Michigan is.
A long road
The first full month of online sports betting came on the heels of a wildly successful late January launch that saw the online sportsbooks handle over $115 million in bets in a 10-day span, with over $13 million in revenue, for a strong 11.5% hold.
Of course, it had been a long road to that point, with years of legislative action culminating in late 2019 when Gov. Gretchen Whitmer signed a comprehensive sports betting and casino bill into law.
Over the course of the next 13 months, the MGCB, working in conjunction with operators, suppliers, and the legislative framework, put the finishing touches on the Michigan gaming product.
In November, the final legislative hurdle was leapt when the Joint Committee on Administrative Rules waived through the rules and regulations MGCB had put into place, paving the way for the dawn of online sports betting and casino play.
And then on Jan. 22 at noon, 10 (now 12) sportsbooks launched in Michigan, beginning probably the most-watched race in the American online sportsbook battles since New Jersey launched in 2018. Why? Because of the same start time for all the sportsbooks. In short: There are no excuses for laggards in the space; all the operators started at the same time under the same set of rules.

redpajama_set_name: RedPajamaCommonCrawl


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Thomas Cadell (1742–1802), often referred to as Thomas Cadell the elder, was a successful 18th-century English bookseller who published works by some of the most famous writers of the 18th century.

The business was continued by his son, Thomas Cadell (1773–1836), often referred to as Thomas Cadell the younger,  who went into business with William Davies as Cadell & Davies until Davies death in 1819. Cadell continued in business until his own death in 1836.

History
Thomas Cadell was born in Bristol to William and Mary Cadell and baptized on 12 November 1742. On 7 March 1758, Cadell's father apprenticed him for a fee of £105 to London bookseller and publisher Andrew Millar. Cadell became Millar's partner in April 1765, having just finished his seven-year apprenticeship, and took over the business with the help of Millar's assistant, Robert Lawless, upon Millar's death in 1768. Now a successful bookseller, Cadell married the daughter of Reverend Thomas Jones on 1 April 1769.

Cadell ran his business out of 141 Strand for over 25 years, sometimes partnering with William Strahan and later Andrew Strahan. He published works by notable authors, whom he paid well. For example, Cadell and Strahan published Edward Gibbon's Decline and Fall of the Roman Empire (1776–88), Henry Mackenzie's The Man of Feeling (1771) and the poetry of Robert Burns. Cadell wrote to Gibbon in 1787: "I had rather risk my fortune with a few such Authors as Mr Gibbon, Dr Robertson, D Hume … than be the publisher of a hundred insipid publications". He also published works by the jurist William Blackstone, the philosopher David Hume, the author and critic Samuel Johnson, the philosopher and economist Adam Smith, the novelist Tobias Smollett, the novelist Frances Burney, the historian Catharine Macaulay, and the moralist Hannah More. He also published the novels of Charlotte Smith until her works became too radical, refusing to publish Desmond in 1792.

Cadell had a strong relationship with Samuel Johnson. Cadell was part of the group of booksellers who convinced the famous critic to write Lives of the Most Eminent English Poets (1779–81). He also published Johnson's political tracts of the 1770s and, together with Strahan, his A Journey to the Western Islands of Scotland (1775). After Johnson died, Cadell published Hester Thrale Piozzi's Letters and Anecdotes about Johnson.

Cadell was well liked by other booksellers and he helped establish the booksellers' dining club which met each month at the Shakespeare tavern in Wych Street. Together, they prosecuted infringements on their copyrights from Scottish and Irish printers.

In January 1786, Cadell's wife died. The couple had two children. His daughter married Dr. Charles Lucas Eldridge, chaplain to George III. His son, Thomas Cadell the younger, took over the family business when his father retired in 1793.

After his retirement, Cadell served on the boards of several philanthropic institutions, such as the Foundling Hospital. In March 1798, he was elected alderman of Walbrook and served as sheriff from 1800 to 1801. He was also master of the Stationers' Company from 1798 to 1799 and stock-keeper in 1800.

Cadell died at his home on 27 December 1802 from an asthma attack.

Notes

Bibliography
Dille, Catherine. "Thomas Cadell, the elder (1742-1802)". Oxford Dictionary of National Biography. Oxford University Press. January 2008. Retrieved 16 February 2009.

External links

 "www.millar-project.ed.ac.uk." University of Edinburgh.

English booksellers
Publishers (people) from London
1742 births
1802 deaths

redpajama_set_name: RedPajamaWikipedia


The Schlegel family's "White Oak Ranch" is a popular wedding venue near Dallas - Ft. Worth located in Pilot Point, TX.
"a perfect mix of rustic and elegance, White Oaks Ranch is an ideal venue for your wedding."
This wedding couple's album begins as they arrive to kick off their luxury destination wedding in Dallas with a casual welcome party for their British and American guests.
The bride is originally from the United Kingdom and fell in love with her fiancee from Highland Park.
When planning their wedding, she decided to make Dallas the destination for her nuptials and invite her friends from London to see "Why everything is BIGGER and better in Texas."
Just north of Dallas, the location includes "The Pavilion" considered to be a spectacular property consisting of 450 acres previously part of John Wayne's family's ranch collection.
If you are into Fashion, check out Krystal Schlegel's personal style blog to see more pictures around the property.
A mainstay of getting married at White Oaks Ranch is having your ceremony under the 500+-years-old oak tree.
Nothing says "I had a destination wedding in Dallas" quite like a gorgeous Texas sunset paired with a massive tree canopy with paper lanterns and some chairs in a field.
Location: 7900 Farm to Market 455 E, Pilot Point, TX 76258.


Today we inspected a home in Goodrich Michigan and located a large maternal colony roosting in the attic. It's important we get rid of the bats before maternity season or we will be waiting until August. Above is an entry point into the attic. Things to look for while locating the entry point of a bats is to look for the dark staining. Staining is caused from the dirt and oils of the bat fur going in and out of the hole. An exclusion device can be installed to evict the bats from the attic and keep them from returning.
Large Pile of bat guano in the attic.
Once we evict the bats from the attic we have to clean out the bat guano for health risk concerns. If the fungi and bacteria in the bat feces becomes airborne the tenants are at risk of lung infection diseases like histoplasmosis. A full attic restoration is requested to get this attic back to its proper state.
I have bats in my family room attic. There is no access to the attic, but an outside gable vent. There is a fireplace were bats can be hiding. They have entered the house twice from that area. Could you possibly evaluate and tell us what we need to do to get rid of the bats and clean up the area. My mom lives in Swartz Creek ,Michigan. She has serious health issues. Please call me at (810) 553-2054 or (810) 635-0436.


text:
King's People
Dr Daniel Orrells
Reader of Ancient Literature & its Reception, Head of Department of Classics
daniel.orrells@kcl.ac.uk
I studied Classics at undergraduate and postgraduate levels at the University of Cambridge. I taught at the University of Warwick for eleven years, including two years as a Humboldt Fellow at the Humboldt University in Berlin. I joined King's College London in 2015.
My research focuses on the history of the interpretation of classical literature. More specifically, I examine the literary, scholarly and cultural receptions of Greek and Latin literature from the Renaissance to the beginning of the twentieth century. My research specialisms can be grouped under the following headings:
Classical literature and literary/critical theory
Modern European literature and classical antiquity
History of gender and sexuality and the ancient world
Classics and Postcolonial literature and theory
Classics and Aesthetics
I have supervised a range of MA and PhD students on classical literature and classical reception studies. I would be very happy to hear from potential students interested in Greek literature and literary/critical theory and the reception of Greek and Roman literature and modern intellectual and literary history.
Expertise and public engagement
I have given public lectures at museums and schools.
Richard Marsh, Popular Fiction and Literary Culture, 1890-1915: Rereading the Fin de Siècle, co-edited with Victoria Margree and Minna Vuohelainen (Manchester University Press, 2018)
The Mudimbe Reader, co-edited with Pierre-Philippe Fraiture (University of Virginia Press, 2016)
Sex: Antiquity and Its Legacy (Oxford University Press USA, 2015)
African Athena: New Agendas, co-edited with Gurminder K. Bhambra and Tessa Roynon (Oxford University Press, 2011)
Classical Culture and Modern Masculinity (Oxford University Press, 2011)
Based in:
Enlightenment Studies
Queer@King's
Hellenic Studies


text:
Q: C# snippet starting up directly environment variables window is not working on Windows 10 I've been using the following piece of code to directly open the Environment variables screen with a single button click:
private void OpenEnvVariables()
{
    Process p = new Process();
    p.StartInfo.WorkingDirectory = @"C:\Windows\System32";
    p.StartInfo.FileName = "rundll32.exe";
    p.StartInfo.Arguments = "sysdm.cpl,EditEnvironmentVariables";
    p.StartInfo.Verb = "runas";
    p.StartInfo.WindowStyle = System.Diagnostics.ProcessWindowStyle.Hidden;
    p.Start();
}

It was working just fine up until the moment I ran my tooling application on Windows 10. And now it does nothing.
Run can still handle sysdm.cpl but it seems that I cannot pass correctly the arguments.
Any help would be appreciated.

A: Update This was auto-resolved somehow, perhaps a Windows Update. It is now working fine.

redpajama_set_name: RedPajamaStackExchange


Clayton and Keeley are my good friends and a married couple whom I admire greatly. Both are working models and actors based in New York City, who also happen to be Christians. It is an incredible privilege to know such strong followers of Christ who take seriously their mission to be God's salt and light in the entertainment industry.
If you missed Part 1 of their interview, be sure to read that here. This is Part 2, where they share with me how they practically minister to their cast and crew on set, how God is moving in Hollywood, and their advice to aspiring Christian actors.
Part 1 >> Read Interview Here.
Part 3 >> Read Interview Here.
MS: Have you kept up with the career of rapper Lecrae at all?
CJ; Lecrae actually just did a film with one of our friends.
KM: Have you heard of the film "Believe Me"?
KM: We know all the guys who made it.
We talk about that. What you create is important and there is a standard in that, but most of our actual ministry is the people that we are working with in the shows.
KM: Our heart is for our cast. And not necessarily for our audience. And Christian theater is more for the audience and you are trying to get a message across. We went to the premiere [of "Believe Me"] and all the actors came to the New York premiere. It's probably the smallest project they have ever worked on. One of them is in Glee, one of them plays the older brother in Unbroken. And they said, "This is the most life-changing, best project I've ever worked on." It was 17 days long.
CJ: You know it was low budget?
MS: It didn't look low budget at all.
CJ: It was well done and it was work. They were working long hours and long shoots.
MS: I had a small viewing at my house. I was excited because I thought people are going to think this is like Saved, the Mandy Moore movie. I said, "No, it looks different." It was good.
CJ: The main actor said, "This is the best film experience that I've ever been a part of." And it was after he had worked with Angelina Jolie.
KM: How incredible is that? There's so much power in that because that is where the change in Hollywood is going to happen. It's going to happen through believers being on set and just loving people.
Like the whole thing with Shia Labeouf. That producer [David Ayer] is a well-known believer in the industry and he obviously has a heart for the people are in his films.
CJ: People see "Fury" and all I hear about Fury is [the use of] the 'F' Word.
KM: We think that's the way that change is going to happen in the entertainment community. And it is. That is happening. People are coming to know Christ. You just have to be very careful about how you publicize it. We have to be careful, even with stuff like this.
For instance, Clayton has written a blog, a director saw it and didn't want to cast him in something because he is a Christian. And so, I've had to tell people, 'Please don't use my whole name in things because people look me up." It's just so interesting with being a Christian. You have to be wise about how you do it.
CJ: There are a lot of Christians in the industry. There are a lot of Christians in theater in New York and in Hollywood. But you have to be wise about how you express that because, like anything, you can get pigeonholed into a certain thing. Christian or not–especially for actors–certain actors get pigeonholed, like Sandra Bullock doing RomComs for years until she forced her way out of that into more substantial roles. Or Matthew McConaughey. It's hard to not get labeled. As an actor, you have to do as much as you can to keep your options open.
MS: I just think of Bieber and the Jonas Brothers. People overemphasize that they are Christians and then they have all this unnecessary pressure. Beside the fact that they were just kids; they didn't know who they were yet. They weren't established in their values. I always pray for them. It's hard they have all this pressure. You are going to want to break out of that.
KM: It's scary for an actor because when you [are vocal about your faith], the Christian community want to make you their superstar and spokesperson. That's not what I came here to do, to be the world's spokesperson on this.
CJ: Certain actors, like Kirk Cameron has done that and he does Christian films that only Christians watch.
KM: But other people would not cast him.
KM: Like Liam Neeson, if you pay close attention, he's a believer. Once you know that and you see the roles that he picks, you can realize it. He's a part of a lot of redemptive films.
KM: And I think that's how Jesus came. Jesus did not come in this overt way where he was lording it, he did not come like a king. He came and he traveled from town to town and he got to know people and he told them stories and told them who he was. If Jesus wanted to, he could have just descended from heaven and said something from a cloud to everyone. But he chose to come as a servant. I think that's the best way to change something or to see renewal in something, is to have the mentality of "I'm a servant." I'm not going to come in with bells ringing and whistles blowing and announce to the world that "I'm here to do this, to save this industry." I think it scares them.
MS: It comes across as superior.
KM: Even if your heart isn't that way, that's how it comes across. As believers, sometimes we have a hard time understanding that because we know that what we believe is true but to other people it comes across as an agenda.
CJ: Everyone has an agenda.
KM: Everyone in Hollywood has an agenda. Every movie has an agenda.
CJ: Every movie has an agenda, it's just if your agenda is in vogue or not in vogue. I think there's a negative connotation with having an agenda.
KM: Look at the Oscar nominations from this year, a lot of them have to do with social rights issues, whether it's gay rights or civil rights–everything is pretty much about the underdogs of society right now. That's just a theme. And Christians are not seen as the underdogs still, even though in a lot of ways, we really are. We are really persecuted.
MS: What would you say to an aspiring actor who does not have as supportive a community as you do? What would you do to encourage them to keep going with their craft?
KM: That makes me really sad because I've met a lot of actors who have said "The church I grew up in or the family or the school, they just think I'm doing the worst thing." Everyone in my life is always so supportive of what I did: my church, my Christian school and they still are.
A big thing I like to talk about is that God has created us with purpose, and the passions that he has placed in us are with purpose. If you feel deeply that this is something that you love to do then there's a reason that God put that in you. He wants to use you. Everything is redemptive. Nothing is secular, everything is sacred. I think a big lie that the enemy lets the Christian community believe is that there are no Christians in New York, there are no Christians in the entertainment industry, there are no Christian actors, and that is just not true. I came here to New York–I've never known so many Christians in the industry as I have here. And I grew up in Texas, which has a thriving community. God is doing really cool things there.
A lot of people don't pursue their career out of fear of what their parents or community will say. But I remember when all the Miley Cyrus stuff was happening how the Christian community was like, "This is what's wrong with entertainment and the world" and all this kind of stuff.
I said my prayer is that parents in the Christian community who have little girls who love to sing would see that and go, "I hope that my daughter goes into that industry because Miley Cyrus needs friends. She needs community and she needs accountability. I'm going to raise my daughter in the right way and I'm going to pray over her life and her faith that the Lord will raise her up and that she will have success in that arena." That's the thing with a lot of those child stars that just don't know. And they don't have this community around them that has true wisdom.
We should see those things and not want to run away from it but run towards it. Those people are hurting and they are in pain. That is why people do stupid things. It's because of sin and pain and hurt. The reason that the Lord has not just called us to be Christian but to be followers of him and be his disciples is to go into those dark places. We need more workers in the field. It's a growing industry. And Clayton and I really think that God is doing something really cool.
CJ: I would also tell [aspiring actors] to be excellent, to seek excellence because that will, like we talked about with service, earn you respect and options. A lot of acting is being in the right place at the right time. We can trust that the Lord's hand is in that. Acting is not something where you can work hard and you are excellent, the reward is guaranteed. It's not something that you can work really hard and put in extra hours and automatically get a promotion. It requires a lot of faith. But regardless of success, which shouldn't be your desire anyway, if you are excellent and if you are serving the industry, you will have respect from Christians and non-Christians.


From the looks of the targets you made the gun-human-weather-bullet system accurate also. Lee December 3, 2010, 6:33 pm Well written article and well illustrates the quality, in terms of accuracy, of what can be had for a relatively modest cost.... Thanks to the current popularity of exceptionally accurate 6.5s such as the 6.5-.284 and 6.5 Creedmoor in long-range competitive shooting, things are a bit different today. You can definitely get really good 6.5mm barrels from any "name" barrel maker, and there are plenty of bullets developed for accuracy.
The Ruger SP101 .357 Magnum, top, is a handy, lightweight defensive handgun, while the GP100, lower, is a dandy all-around packing and hunting gun.
Thanks to the current popularity of exceptionally accurate 6.5s such as the 6.5-.284 and 6.5 Creedmoor in long-range competitive shooting, things are a bit different today. You can definitely get really good 6.5mm barrels from any "name" barrel maker, and there are plenty of bullets developed for accuracy.
Police radar guns are one of the main tools that police officers use to issue speeding tickets. Here we generally focus on the best radar detectors, but by learning more about how police radar operates and is used, we'll have a better understanding of the big picture and what we can do to defeat it.


Dare, desire, quiver. These three words written on the front of the Opéra Bastille make it clear that modernity is now a statement of the institution. Founded in 1713, the Opéra National de Paris' dance school keeps evolving in terms of techniques and practice, renewing itself while keeping its tradition. These values are dear to Merlet, the shoemaker and shoe licensee of Opéra National de Paris, who makes the pretty shoes that will seduce dance-loving young ladies! Created and designed in a small workshop of France's Limousin region which was established in 1974, Opéra National de Paris shoes make their debut on Sarenza to bring a graceful and timeless touch to women's feet.
Do you love Opéra national de Paris as much as we do?


text:
Helen V. Milner
Princeton University - Woodrow Wilson School of Public and International Affairs
Princeton University - Department of Political Science
Professor of Politics and International Affairs
Corwin Hall
Which Devil in Development? A Randomized Study of Citizen Actions Supporting Foreign Aid in Uganda
Helen V. Milner, Daniel L. Nielson and Michael Findley
Princeton University - Woodrow Wilson School of Public and International Affairs, Brigham Young University and Brigham Young University - Department of Political Science
foreign aid, development, international institutions, multilateralism, clientelism
Foreign Direct Investment and Institutional Diversity in Trade Agreements: Credibility, Commitment, and Economic Flows in the Developing World, 1971-2007
Forthcoming in World Politics vol.66 no.1 (January 2014), Revised APSA 2011 Annual Meetings Paper
Number of pages: 44 Posted: 28 Mar 2011 Last Revised: 06 Jul 2013
Tim Buthe and Helen V. Milner
Technische Universität München (TUM) - School of Governance - Hochschule für Politik and Princeton University - Woodrow Wilson School of Public and International Affairs
foreign direct investment, trade agreements, GATT, WTO, international institutions, credibility, commitments, governance, PTAs
The Interaction of International and Domestic Institutions: Preferential Trade Agreements, Democracy, and Foreign Direct Investment
APSA 2012 Annual Meeting Paper
foreign direct investment, institutions institutional interaction, trade agreements, PTAs, democracy, MNCs, political risk, credible commitment
Economic and Cultural Sources of Preferences for Globalization in Egypt
APSA 2013 Annual Meeting Paper, American Political Science Association 2013 Annual Meeting
Amaney Jamal and Helen V. Milner
Princeton University - Department of Political Science and Princeton University - Woodrow Wilson School of Public and International Affairs
public opinion, globalization, Islam, Egypt
The Choice for Multilateralism: Foreign Aid and American Foreign Policy
Number of pages: 39 Posted: 01 Aug 2011 Last Revised: 03 Aug 2011
Helen V. Milner and Dustin H. Tingley
Princeton University - Woodrow Wilson School of Public and International Affairs and Harvard University - Department of Government
International Political Economy Society 2010 Annual Meeting
Helen V. Milner and Dustin Tingley
Princeton University - Woodrow Wilson School of Public and International Affairs and Princeton University - Department of Political Science
multilateralism, foreign policy, foreign aid, principal-agent
The Political Economy of Inward FDI: Opposition to Chinese Mergers & Acquisitions
Chinese Journal of International Politics, vol. 8, no.1, p. 27-57, 2015
Number of pages: 45 Posted: 20 Aug 2014 Last Revised: 15 Feb 2015
Dustin H. Tingley, Christopher Xu, Adam S. Chilton and Helen V. Milner
Harvard University - Department of Government, Princeton University, University of Chicago - Law School and Princeton University - Woodrow Wilson School of Public and International Affairs
The Economic and Political Influences on Different Dimensions of United States Immigration Policy
immigration policy, United States, political economy, public opinion, Congress
Public Opinion and Foreign Aid: A Review Essay
International Interactions, Volume 39, Number 3, Forthcoming
foreign aid, public opinion, international relations, international cooperation
Who Supports Global Economic Engagement? The Sources of Preferences in American Foreign Economic Policy
International Organization, 2010
foreign aid, trade, congress, policy substitution, domestic politics, President
International Systems and Domestic Politics: Linking Complex Theories with Empirical Models in International Relations
Stephen Chaudoin, Xun Pang and Helen V. Milner
University of Illinois at Urbana-Champaign, Princeton University and Princeton University - Woodrow Wilson School of Public and International Affairs
Reciprocity and Public Opposition to Foreign Direct Investment
British Journal of Political Science, Forthcoming, University of Chicago Coase-Sandor Institute for Law & Economics Research Paper No. 808
Number of pages: 64 Posted: 07 Jun 2017 Last Revised: 15 Sep 2017
Adam S. Chilton, Helen V. Milner and Dustin H. Tingley
University of Chicago - Law School, Princeton University - Woodrow Wilson School of Public and International Affairs and Harvard University - Department of Government
International Political Economy; Foreign Direct Investment; Mergers & Acquisitions; Reciprocity; Public Opinion; Survey Experiments
The Global Spread of the Internet: The Role of International Diffusion Pressures in Technology Adoption
Presented at the 2nd Conference on Interdependence, Diffusion, and Sovereignty, UCLA, California, March 2003
internet, diffusion, domestic policy, leadership
Democracy and Trade Policy in Developing Countries: Particularism and Domestic Politics with a Case Study of India
Helen V. Milner and Bumba Mukherjee
Princeton University - Woodrow Wilson School of Public and International Affairs and Pennsylvania State University
trade policy, liberalization, international trade, particularism, protectionism, India, labor mobility, median voter
The Center Still Holds: The Potential for Liberal Internationalism Survives
International Security, Forthcoming
Stephen Chaudoin, Helen V. Milner and Dustin Tingley
University of Illinois at Urbana-Champaign, Princeton University - Woodrow Wilson School of Public and International Affairs and Princeton University - Department of Political Science
liberal internationalism, bipartisanship, Congress, roll call voting
Trade Policy, Economic Interests and Party Politics in a Developing Country: The Political Economy of CAFTA
International Studies Quarterly, Forthcoming
Raymond Hicks, Helen V. Milner and Dustin H. Tingley
Princeton University - Woodrow Wilson School of Public and International Affairs, Princeton University - Woodrow Wilson School of Public and International Affairs and Harvard University - Department of Government
CAFTA, Costa Rica, trade policy, political economy, trade liberalization, regionalism, referendum, public opinion
The Political Economy of U.S. Foreign Aid: American Legislators and the Domestic Politics of Aid
Economics and Politics, Forthcoming
foreign aid, domestic politics, Stolper-Samuelson, Congress
Economics & Politics, Vol. 22, Issue 2, pp. 200-232, July 2010
File name: ecpo.pdf
Presidential Influence Versus Congressional Control in Action (Chapter 4)
Number of pages: 79 Posted: 29 Nov 2012 Last Revised: 29 Apr 2013
President, Congress, Foreign Policy, Two Presidencies, National Security
Democracy and the Skill-Bias in Trade Policy in Developing Countries
trade policy, trade liberalization, median voter, skill bias
Democracy, Veto Players and the Depth of Regional Integration
World Economy, Vol. 31, Issue 1, pp. 67-96, January 2008
Edward D. Mansfield, Helen V. Milner and Jon C. Pevehouse
affiliation not provided to SSRN, Princeton University - Woodrow Wilson School of Public and International Affairs and affiliation not provided to SSRN
File name: twec.pdf
Taxation Without Representation? Experimental Evidence from Ghana and Uganda on Citizen Action Toward Taxes, Oil, and Aid
World Bank Policy Research Working Paper No. 8137
Brandon de la Cuesta, Helen V. Milner, Daniel L. Nielson and Stephen Knack
Princeton University - Department of Political Science, Princeton University - Woodrow Wilson School of Public and International Affairs, Brigham Young University and World Bank - Development Research Group (DECRG)
Public Finance Decentralization and Poverty Reduction, Macro-Fiscal Policy, Public Sector Economics, Global Environment, Economic Adjustment and Lending, Non Governmental Organizations, Taxation & Subsidies, Economics and Institutions, Public Sector Management and Reform
The Charmed Life of Superstar Exporters: Survey Evidence on Firms and Trade Policy
Journal of Politics: 10. DOI: 10.1086/687207
Posted: 30 Nov 2017 Last Revised: 12 Dec 2017
Iain Osgood, Dustin H. Tingley, Thomas Bernauer, In Song Kim, Helen V. Milner and Gabriele Spilker
Harvard University, Harvard University - Department of Government, ETH Zurich, Massachusetts Institute of Technology, Princeton University - Woodrow Wilson School of Public and International Affairs and ETH Zurich - Center for Comparative and International Studies
firms, trade, preferences, firm heterogeneity, lobbying
Democratization and Economic Globalization
Annual Review of Political Science, Vol. 12, June 2009
democratic transition, trade liberalization and openess, capital accoutn and financial liberation, Stolper-Samuelson theorem, skill premium
Annual Review of Political Science, Vol. 12, pp. 163-181, 2009


text:
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/**
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interface StreamInterface
{
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     * Is validate transport in system
     *
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     */
    public static function isTransport($transport);

    /**
     * Get all allowed wrappers in system
     *
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    public static function getWrappers();

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     * Is wrapper allowed in system
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    public static function isWrapper($wrapper);

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     * Get full path file, included all paths
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}

redpajama_set_name: RedPajamaGithub


text:
Die Echten Hirsche (Cervini) sind eine Tribus der Hirsche (Cervidae). Die derzeit rund 40 Arten dieser Gruppe leben größtenteils in Eurasien, ein geringerer Teil auch in Nordamerika. Am bekanntesten davon sind der Rothirsch und der Damhirsch.

Merkmale
Sie sind charakterisiert durch eine "plesiometacarpale" Zehenstellung (das heißt, dass nur die proximalen (am Fuß anliegenden) Teile der verkleinerten 2. und 5. Zehen vorhanden sind). Dieses Merkmal teilen sie mit den Muntjakhirschen, die ihre nächsten Verwandten darstellen, von denen sie sich aber durch das größere, verzweigtere Geweih deutlich unterscheiden.

Systematik
Folgende Gattungen und Arten werden unterschieden:
 Tribus Cervini Goldfuss, 1820
 Gattung Axishirsche oder Fleckenhirsche (Axis C. H. Smith, 1827)
 Axishirsch oder Chital (Axis axis (Erxleben, 1777))
 Axis porcinus-Gruppe
 Hinterindischer Schweinshirsch (Axis annamiticus (Heude, 1888))
 Calamian-Hirsch oder Calamian-Schweinshirsch (Axis calamianensis (Heude, 1888))
 Bawean-Hirsch oder Bawean-Schweinshirsch (Axis kuhlii (Temminck, 1836))
 Schweinshirsch (Axis porcinus (Zimmermann, 1780))
 Gattung Damhirsche (Dama Frisch, 1775)
 Damhirsch (Dama dama (Linnaeus, 1758))
 Mesopotamien-Damhirsch (Dama mesopotamica (Brooke, 1875))
 Gattung Elaphurus Milne-Edwards, 1866
 Davidshirsch (Elaphurus davidianus Milne-Edwards, 1866)
Gattung Zackenhirsche (Rucervus Hodgson, 1838)
 Hochland-Barasingha (Rucervus branderi Pocock, 1943)
 Tiefland-Barasingha (Rucervus duvaucelii (Cuvier, 1823))
 Assam-Barasingha (Rucervus ranjitsinhi (Groves, 1983))
 † Schomburgk-Hirsch (Rucervus schomburgki (Blyth, 1863))
 Gattung Leierhirsche (Panolia Gray, 1843)
 Manipur-Leierhirsch (Panolia eldii (McClelland, 1842); auch Rucervus eldii)
 Thailand-Leierhirsch (Panolia siamensis (Lydekker, 1915); auch Rucervus siamensis)
 Myanmar-Leierhirsch oder Burma-Leierhirsch (Panolia thamin (Thomas, 1918); auch Rucervus thamin)
 Gattung Edelhirsche oder Rothirsche (Cervus Linnaeus, 1758)
 Weißlippenhirsch (Cervus albirostris Przewalski, 1883; auch Przewalskium albirostris)
 Cervus elaphus-Gruppe (westliche Rothirsche)
 Korsischer Rothirsch oder Tyrrhenischer Rothirsch (Cervus corsicanus Erxleben, 1777)
 Rothirsch oder Westeuropäischer Rothirsch (Cervus elaphus Linnaeus, 1758)
 China-Rothirsch (Cervus hanglu Wagner, 1844)
 Kaukasushirsch oder Kaukasusmaral (Cervus maral Gray, 1850)
 Osteuropäischer Rothirsch (Cervus pannoniensis Banwell, 1997)
 Cervus canadensis-Gruppe (östliche Rothirsche und Wapitis)
 Alashan-Wapiti (Cervus alashanicus Bobrinskii & Flerov, 1935)
 Wapiti (Cervus canadensis Erxleben, 1777)
 Szetschuan-Hirsch (Cervus macneilli Lydekker, 1909)
 Tibetischer Rothirsch oder Schou (Cervus wallichii Cuvier, 1823)
 Isubrahirsch (Cervus xanthopygus Milne-Edwards, 1867)
 Cervus nippon-Gruppe (Sikahirsche)
 Nordhonshu-Sikahirsch (Cervus aplodontus (Heude, 1884))
 Dybowski-Hirsch (Cervus hortulorum Swinhoe, 1864)
 Sikahirsch oder Japanischer Sikahirsch (Cervus nippon Temminck, 1838)
 Vietnamesischer Sikahirsch (Cervus pseudaxis Gervais, 1841)
 Tsushima-Hirsch (Cervus pulchellus Imaizumi, 1970)
 Sichuan-Sikahirsch (Cervus sichuanicus Guo, Chen & Wang, 1978)
 Taiwan-Sikahirsch (Cervus taiouanus Blyth, 1860)
 Cervus unicolor-Gruppe (Sambarhirsche)
 Prinz-Alfred-Hirsch (Cervus alfredi Sclater, 1870; auch Rusa alfredi)
 Mindoro-Sambar (Cervus barandanus (Heude, 1888); auch Rusa barandana)
 Sumatra-Sambar (Cervus equinus G. Cuvier, 1823; auch Rusa equina)
 Philippinenhirsch (Cervus mariannus Desmarest, 1822; auch Rusa marianna)
 Mindanao-Sambar (Cervus nigellus (Hollister, 1913); auch Rusa nigella)
 Mähnenhirsch (Cervus timorensis de Blainville, 1822; auch Rusa timorensis)
 Sambar (Cervus unicolor Kerr, 1792; auch Rusa unicolor)

Die Systematik der Echten Hirsche ist komplex. Die Gattungen Elaphorus, Rucervus und Rusa wurden ursprünglich in einer gemeinsamen Gattung, den Edelhirschen (Cervus) zusammengefasst. Aufgrund von Untersuchungen der Verwandtschaft zwischen den Edelhirschen und Vertretern anderer Hirschgattungen, die vor allem von B. C. Emerson und M. L. Tate im Jahr 1993 vorgestellt wurden, wurde die Gattung als paraphyletisch erkannt. Den Analysen zufolge waren die Sambarhirsche (Rusa) dichter mit den Damhirschen (Dama) und den Axishirschen (Axis) als mit anderen Edelhirschen verwandt. Der Rothirsch und der Sikahirsch sollten wiederum eine gemeinsame Klade mit dem Davidshirsch bilden.     Dem Rechnung tragend, wurden diese Verwandtschaftsgruppe in die vier Gattungen Cervus, Elaphorus, Rucervus und Rusa aufgeteilt. Spätere Untersuchungen ergaben jedoch, dass die Gattung Rucervus in ihrer damaligen Definition ebenfalls paraphyletisch ist und einerseits mit den Axishirschen verbunden ist (Barasinghas), andererseits den Edelhirschen nahesteht (Leierhirsche). Demzufolge wurde letztere als Gattung Panolia abgespalten. Die Sambarhirsche wiederum erwiesen sich als tiefer in die Edelhirsche eingebettet als anfangs angenommen. Gleiches gilt für den Weißlippenhirsch, der häufig noch mit der eigenständigen Gattung Przewalskium ausgehalten wird. Auch hier zeigen genetische Daten, dass die Art tief in der Gattung Cervus verankert ist, wodurch sowohl Rusa als auch Przewalskium nun zu den Edelhirschen gezählt werden. Alternativ besteht der Vorschlag, dass der gesamte Verwandtschaftskomplex mit Elaphurus und Panolia wieder zu Cervus zusammengeführt wird.

Genetische Untersuchungen haben auch dazu geführt, dass einige Unterarten des Rothirsches jetzt Artstatus erhalten. Rothirsche, Wapiti und die Hangule ordnete man alle als Cervus elaphus ein und unterstellte eine kontinuierliche Verbreitung von Eurasien bis nach Nordamerika. Als Beleg für diese These galt, dass diese Hirsche untereinander fruchtbaren Nachwuchs zeugen konnten. DNA-Untersuchungen an hunderten von Tieren haben zu einer anderen Arteinteilung geführt: Demnach bestehen mehrere größere Verwandtschaftsgruppen innerhalb der ehemaligen Art Cervus elaphus, die einerseits die westlichen Rothirsche (Cervus elaphus-Gruppe) mit einer Verbreitung in Europa, Nordafrika und Kleinasien, andererseits die östlichen Wapitis (Cervus canadensis-Gruppe) mit einer Verbreitung im östlichen Nordasien und Nordamerika umfassen. Letztere stehen zudem den Sikahirschen (Cervus nippon-Gruppe) näher. Aufgrund dessen wurde während einer Revision der Hirsche aus dem Jahr 2011 zahlreiche ehemalige Unterarten von Cervus elaphus in den Artstatus erhoben.

Literatur
 Colin Groves und Peter Grubb: Ungulate Taxonomy. Johns Hopkins University Press, 2011, S. 1–317 (S. S. 71–107)
 S. Mattioli: Family Cervidae (Deer). In: Don E. Wilson, Russell A. Mittermeier (Hrsg.): Handbook of the Mammals of the World. Volume 2: Hooved Mammals. Lynx Edicions, Barcelona 2011, ISBN 978-84-96553-77-4, S. 350–443
 Ronald M. Nowak: Walker's Mammals of the World. The Johns Hopkins University Press, Baltimore 1999, ISBN 0-8018-5789-9.
 Don E. Wilson, DeeAnn M. Reeder (Hrsg.): Mammal Species of the World. 3. Ausgabe. The Johns Hopkins University Press, Baltimore 2005, ISBN 0-8018-8221-4.

Weblinks

Einzelnachweise

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The classes are sorted by Convocation within the Diocese of Texas. Please check with individual mentors about class changes and enrollment information. Most groups run for an academic year with a September start date.


Loops are very important when programming, that is the way you can take full advantage of the speed of computers to solve different problems.
Computers are great at doing repetitive task, and they are fast too.
I can still remember when being a child I started coding with Basic (Yes the old Basic), and Do…While, Do…Until and For were some of the most important lessons learned, together with IF statement.
Now, that I use Linux and Mac OSX a lot, I take full advantage of For…Loop. Specially when working with a lot of files at a time.
In computer science a for loop is a programming language statement which allows code to be repeatedly executed. A for loop is classified as an iteration statement. Unlike many other kinds of loops, such as the while loop, the for loop is often distinguished by an explicit loop counter or loop variable. This allows the body of the for loop (the code that is being repeatedly executed) to know about the sequencing of each iteration. For loops are also typically used when the number of iterations is known before entering the loop. For loops are the shorthand way to make loops when the number of iterations is known, as a for loop can be written as a while loop. The name for loop comes from the English word for, which is used as the keyword in most programming languages to introduce a for loop. The loop body is executed "for" the given values of the loop variable, though this is more explicit in the ALGOL version of the statement, in which a list of possible values and/or increments can be specified.
In most computer programming languages, a while loop is a control flow statement that allows code to be executed repeatedly based on a given boolean condition. The while loop can be thought of as a repeating if statement.
With that understood, lets start with Bash for loop article.
Is instructing For to act and a predefined list of elements, with the for … in statement.
Watch these simple examples of each way.
The result will be the same in both cases, this is the output.
That will count with 5 to 5 steps.
One of the best uses for loop have in Bash is when you are working on files.
It will ask you how many prime numbers you want, and then will look for those prime numbers. It is using a For Loop, to divide a number between all numbers and find if it is only divisible between 1 and itself.
Sometimes you may want to break the loop before it actually finish executing, for example, you are looking for a condition to be met, you can check the status of a variable for that condition. Once the contidition is met, you can break the loop. Here is how.
With the use of if ... then you can insert a condition, and when it is true, the loop will be broken with the break statement.
continue # skip to the next value in "series"
As you can see they are similar. But with break you will completely stop the loop, and with continue you will stop the execution of the commands in the loop and jump to the next value in the series.
When using bash, the for loops are not always inserted in scripts, so you may find yourself using them directly in the command line. For this situations you need to use one liners.
When you are counting the times a command will be repeated (not very used in command line actually) you have one these syntax options.
Where n is the lower number and m the higher one, so if you want to say Hello 3 times.
Once again n is the lower number and m the higher, i++ is a counter, that is incrementing one by one. To do the same example as above.
In the parenthesis you have three parts, the first one is setting the initial value i=1, the second is comparing a condition, i<=3, and the last one is the counter i++.
You can do some pretty interesting things with this.
It will count the even numbers up to 30.
But the real reason to work with bash for loop in command line, and using one liners is to work with files.
Let's say you want to copy backup all pdf files.
Add a extension .bak to all .txt files.


Your Time Investment Are Justified By the Fee Earnings Govt Naukri specifically preferred essentially the most: There are websites and intermediaries who can level the novice borrower in the fitting path. An important entrepreneur knows to grab an advantage when it is introduced.
Selling products as an affiliate is another choice when working from home. You can sell magnificence merchandise for several corporations by organising a assessment website. You evaluate and recommend sure products and give your visitors a link to go to the product owner's website to purchase the product. When a sale is completed, you will obtain a commission. You'll not have to stock products or do any packing and shipping. You may as well promote your critiques to different entrepreneurs. Promoting info on the Web is a very profitable method to work at home.
An efficient therapy for respiratory ailments. Body cleans itself of toxins and waste. Stimulates the immunity system within the body. Radiates the skin tone. Increases flexibility in the body. Expands the blood vessels which improve circulation. Relaxes muscular tissues and joints It may be the most stress-free part of the day, and is like having your personal spa at dwelling. But steam showers should not be utilized by individuals with cardiovascular illnesses, or excessive BP. Small children and pregnant women also needs to keep from it. Take some primary precautions like Do not take shower instantly after an intense exercise. Drink lots of water earlier than taking a steam bath to avoid dehydration. Don't use steam bathtub for greater than twenty minutes. Avoid utilizing steam room for those who see open wounds. An important factor to remember is that the steam that comes from the unit needs an outlet.
– Wait productively. There isn't any strategy to keep away from waiting in airports, especially nowadays. But you can keep away from losing that point. Bring work with you. If that's not attainable, convey these skilled journals you are behind on to read. Keep a provide of note cards in your briefcase and write some personal notes to purchasers, colleagues or buddies. Learn a novel–somewhat escapism is a good stress-reducer. Strike up conversations with your fellow passengers, however hold the tone constructive. This is usually a nice opportunity for networking, so don't dwell on the unfavorable elements of the state of affairs. You should definitely pass out business playing cards when applicable. If you're going to make calls on your cellular phone, step away from the crowd so you do not distract others together with your half of a telephone conversation.
Electronic mail has change into part of our everyday interaction. You ship a fast note out to pals, just be sure you ship reminders about meetings and even communicate with people who are thousands of miles away. And though email has change into the norm, that doesn't mean we are able to overlook in regards to the power it has with generating leads for new customers. But if you are going to use electronic mail effectively, you'll must transcend your everyday email habits. Here are some methods you can go from a easy email to generating extra leads on your company.
It is also very convenient to make and order custom prints. By the web, ordering and designing your supplies can easily be finished. Simply log on to the corporate web site and place your orders ? it's that easy. Additionally, most of the online printing corporations provide free venture quotes that will just remember to don't print what you do not need.
Similarly with this business you won't need to work in the nine to five jobs, that can break any innovative soul easily. The character of this work is which you can begin working with little funding, just few belongings you would possibly begin to work in direction of your fortune quite easily too. This may be your starting point but discovering your share in the pot of gold continues to be achievable too.


text:
Synnerby församling var en församling i Skara stift och i Skara kommun. Församlingen uppgick 2006 i Ardala församling.

Administrativ historik
Församlingen har medeltida ursprung.

Församlingen var före 1545 i pastorat med Sankt Pers församling som moderförsamling. Från 1545 till 1551 annexförsamling i pastoratet Synnerby och Skallmeja. Från 1551 till 1962 annexförsamling i pastoratet Synnerby, Skallmeja och Gerum som före 1575 även omfattade Skånings-Åsaka församling. Från 1962 till 1992 moderförsamling i pastoratet Synnerby, Skallmeja, Västra Gerum, Marum och Vinköl. Från 1992 till 2002 annexförsamling i pastoratet Synnerby, Skallmeja, Vinköl och Marum-Gerum. Församlingen ingick mellan 2002 och 2006 i Skara pastorat och uppgick 2006 i Ardala församling.

Kyrkor
 Skallmeja kyrka

Se även
Skallmeja socken

Källor

Historiska församlingar i Skara stift

Indelningar i Skara kommun


Toronto, ON – The Canadian Hockey League today announced that Brandon Saad of the Saginaw Spirit is the CHL Player of the Week for the week ending October 23. Saad scored six goals and added four assists for 10 points in three games with a plus-minus rating of plus-2.
Saad led the Spirit to three straight road wins beginning last Thursday night where he recorded his first career five-point game as part of a 5-2 win over the Brampton Battalion. In the win Saad scored a career-best four goals including a natural hat-trick and added one assist as first star of the game. On Saturday night he earned second star honours scoring a goal as part of a 9-1 win over the Peterborough Petes before claiming first star honours on Sunday night closing out his week with a goal and a career-best three assists for four points in a 7-6 win over the Oshawa Generals.
Saad, who will celebrate his 19th birthday on October 27, is from Gibsonia, Pennsylvania. The second year forward was selected 43rd overall in the 2011 NHL Entry Draft by the Chicago Blackhawks and played two NHL games this season before returning to the Spirit where he has recorded 13 points in five games.
Also considered for the award this week was Danick Gauthier of the Saint John Sea Dogs and Brendan Gallagher of the Vancouver Giants. Gauthier scored six goals in three games while Gallagher picked up seven points in three games scoring three goals and four assists.


Jens Figal is responsibly for the strategical and further development of the product portfolio with the solutions in the areas of mobile, location-based services and cloud.
With his team he works on the product Deep MapTM and in the areas of Research and innovation for solutions to questions in the spatial context.
He was previously employed at Deutsche Telekom AG within the unit Products & Innovation and worked on the development and launch of mobile solutions for enterprise customers and internationally active telco services.
Jens Figal is a media and communication scientist and enthusiastic by the diversity about human-computer interaction.
Timothy Ellersiek is one of the core developers of Openrouteservice (ORS) – a free to use route planning service purely based on Openstreetmap data. ORS is developed by the Heidelberg Institute for Geoinformation Technology (HeiGIT) funded by the Klaus Tschira Stiftung. The API offers all different kinds of profiles and options providing the user with a highly customizable environment to plan routes all over the globe.
HeiGIT is directed by Prof. Alexander Zipf.
President of the Association for Geoinformatics, GeoIT and Navigation e.V.


Zhai Dongsheng and Fu Zhiguang are authors contribute equally to this work.
Activated macrophages exhibiting diverse phenotypes and various functions contribute to the pathogenesis or amelioration of different diseases like cancer, inflammation, and infectious and autoimmune diseases. However, the mechanisms of macrophage polarization in inflamed joint and its effects on rheumatoid arthritis (RA) are still not clarified. This study is designed to explore the effects of cyclophilin A (CypA) on macrophage polarization and describe the underlying mechanisms. Collagen-induced arthritis (CIA) was employed to address the pro-arthritic effects of CypA. Flow cytometry was performed to investigate the populations of M1 and M2 macrophages in synovial tissues of the mice. Knockdown or overexpression of CypA macrophage cells was used to study the functions of CypA on macrophage polarization. Western blot was carried out to examine the potential signaling pathways. We found that CypA aggravated the severity of CIA in mice, as assessed by the increase of clinical score of inflammation, cartilage damage, and bone erosion. Moreover, the level of cytokines, such as IL-6, IL-1β, and IL-17, and the number of pro-inflammatory macrophages in synovial fluid were significantly elevated. In accordance with our observation, CypA dysregulation could actually influence the M1 macrophages polarization and pro-inflammatory cytokines production. Further mechanism study disclosed that CypA could regulate the transcriptional activity of NF-κB, the pivotal transcriptional factor regulating M1 polarization, dependent of its PPIase activity. Our findings provide evidence that PPIase CypA promoted macrophages polarization toward pro-inflammatory M1 phenotype via transcriptional activating NF-κB, thus leading to aggravated arthritis.


Life Is Strange is back with a prequel, Before The Storm. It hasn't disappointed fans, who are documenting the feels it gave them all over the Steam reviews.
I was a little worried about Before The Storm. I didn't think we needed a prequel, Chloe's new voice actor sounded a little off, and I was afraid that adding to the canon of the game would kind of ruin it. The good news is it seems pretty good! At least, reviews on Steam indicate that it's sad and gay.
You can check out more reviews for Life Is Strange: Before The Storm here, or read our ongoing "As Told By Steam Reviews" feature here.


A new brand of Colorado hunter is proliferating along the Front Range.
It was a book that convinced Bilich to learn to hunt. Michael Pollan's The Omnivore's Dilemma depicted the American meat production industry in such a disturbing way that the bike-commuter, gardener, and self-described liberal decided years ago to either become a strict vegetarian or become more a part of her own ecosystem. One hunter safety course, a high-powered rifle, and lots of target practice later, Bilich has killed—and she and her family have eaten the meat from—two deer and one elk.
What should the future of the 16th Street Mall look like?
To third- and fourth-generation Colorado hunters, the start-to-finish process of pulling a big-game license in the spring to field-dressing an elk in the fall might be commonplace. But to those who grew up thinking meat came in cellophane-wrapped packages from the refrigerated aisle at King Soopers, hunting is a new experience that represents the ultimate locavore pursuit—and it's a pastime that's undergoing a notable renewal.
The number of hunters in the United States jumped nine percent between 2006 and 2011, according to the U.S. Fish and Wildlife Service. Colorado's numbers show steady growth with a roughly five percent increase in big-game licenses since 2012. In Denver, there's been an almost 10 percent increase in the number of big-game permits issued to city residents in the past four years, according to data from Colorado Parks and Wildlife (CPW), the agency that manages the state's wildlife and hunting programs. Last year, the number of people attending the state's hunter education safety course jumped to 20,000 from an average of approximately 13,500 in years prior (in Colorado, hunters are required to pass this course once).
Hunters have long championed conservation, dating back to President Theodore Roosevelt, who helped establish the U.S. Forest Service and five national parks, including Colorado's Mesa Verde National Park. Famed 20th-century naturalist Aldo Leopold was an avid hunter; in his writings, Leopold reveres the hunter's ability to truly know a landscape and cautions about the impacts of civilization intruding on the wild.
Today, hunting is big business. According to a 2008 state-commissioned report, the economic impact in Colorado is estimated at around $1.8 billion when combined with fishing. Nonresidents pay hundreds of dollars for the chance to bag a Colorado buck, while residents pay nominal license fees, generally $34 for a deer and $49 for an elk. According to the nonprofit group Hunting Works for Colorado, big-game hunting alone generates roughly $763 million in annual economic benefits.
Although Severa does point to a successful hunt as an inexpensive way to eat hormone- and steroid-free meat at home ("If you pay for that high-quality meat at the store, it's going to cost you a fortune"), he says hunters more often venture into the woods for cultural and philosophical reasons, something more akin to the feelings of Aldo Leopold. That's what tempted 40-year-old Rob Fineberg, a second-year student at the University of Colorado School of Medicine, to don camouflage and practice his elk bugle.
This article appeared in the October 2016 issue of 5280.


It is a good software engineering practice to clearly separate the domain from its views. This is a common practice which allows one to change the rendering or even the rendering framework without having to deal with the internal aspects of the model. Thus, we will begin by presenting a simple model for a todo list that contains todo items as shown by Figure 97.
Figure 97: A simple model with items and an item container.
ToDoItem Class. A todo item is characterized by a title, a due date and a status which indicates whether the item is done.
It has accessor methods for the instance variables title, due and done.
A word about initialize and new. Squeak/Pharo is the only Smalltalk dialect that performs automatic object initialization. This greatly simplifies the definition of classes. If you have defined an initialize method, it will be automatically called when you send the message new to your classes. In addition, the method initialize is defined in the class Object so you can (and are encouraged) to invoke potential initialize methods of your superclasses using super initialize in your own initialize method. If you want to write code that is portable between dialects, you should redefine the method new in all your root classes (subclasses of Object) as shown below and you should not invoke initialize via a super call in your root classes.
In this book we follow this convention and this is why we have not added super initialize in the methods ToDoItem>>initialize and ToDoList>>initialize.
ToDoList Class. We now create a class that will hold a list of todo items. The instance variables will contain a title and a list of items. In addition, we define a class variable Default that will refer to a singleton of our class.
You should next add the associated accessor methods title, title:, items and items:.
We define two methods to add and remove items.
Now we define the class-side method default that implements a lazy initialization of the singleton, initializes it with some examples and returns it. The class-side method reset will reset the singleton if necessary.
Finally, we define a method to add some todo items to our application so that we have some items to work with.
Now evaluate this method (by selecting the self initializeExamples text and selecting do it from the context menu). This will populate our model with some default todo items.
Now we are ready to define our seaside application using this model.


There may have been a sequel to the popular crossover, but we still can't get enough of the Dreamcast classic. Servbots, Wolverine, and all he other wacky comic and arcade selections were iconic pieces of our youth and integral to the fighting scene as a whole. No scrubs allowed, bro.


You should find Sierra/Pharaoh/save on your C: drive (or something very similar!) Create a folder in "save" called "download" (or any other name of choice) and then download the saved game to that folder.
In Pharaoh you will then find a family called "download"and can load the game from there.
Your download path will also differ if you bought it from GOG.com. if you don't know where the files are located you can always right click on the shortcut and select the properties option and you'll have access to the file path.
To use bizibilder's recommendation for creating another family to loading downloaded saved games, you need to create that family in Pharaoh.
If you want to download a scenario that is a .map file, it needs to go into the Maps folder (instead of into a family folder). Then you can select the mission from Custom Missions.


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Another Pooooost
Edit: (7/4/14) Screenshot added.
Something to do with ghosts... or not.
I have a Let's Play video up for the first time ever where I talk waaay too much and derp up some audio stuff. Jeremy told me to buy Broforce and because I can, I did. Here's our first adventures into Broforce. There are player built levels that we're going to tackle next. Hopefully they're multiplayer as well, if they are, I'll do another video of those.
Jeremy's voice is no longer a mystery.
There's a bit of in-joke lingo we use. I didn't initially intend to upload the video, and was just recording for the sake of recording it.
DT3 Stuff
For this, I'm currently coding some sort of turret that can detach itself from the wall and then fly around raining down a hellstorm of bombs.
There's quite a bit going on here that isn't apparent in the image.
Another Great Game
Is Shovel Knight which was just released shortly ago. I don't think I need to say much about it. It's on the WiiU, 3DS, and PC (+Steam). The link there is the game's official site, which has all the infos and a video.
You could also check out Brian's LP of it. Looks like he's doing that and Tobias. He'll be finishing Tobias, he has no choice really.
Chapter 18 is going along well, slowly because real life is being a needy female dog right now. Lots of new AI to code as well. Jerry and Claire get to face off against probably the toughest enemies in the trilogy. These guys are the bulk of the end-game combat. Maybe a video to showcase just a single group, maybe not. Probably not, it gives away surprises.
Posted by ZephyrBurst at 2:00 AM 1 comment:
I Feel Like I Need To Mention This
Have you heard about 'Tobias and the Dark Sceptres'? There's a link that I think you should follow in the previous sentence. This was shared to me by two people already. It's a game that was made in the span of 13 years, the video shown in the link 4 sentences ago will tell you all about it. I think you should have a go at this, I recently watched WhattayaBrian's first Let'sPlay video of the game and I'm getting some good vibes from it. It's an odd game, definitely made by someone who started it when they were young, with a few technical oddities. However, there's a certain charm about it that's really nifty and there's a lot of really cool little touches that show the creator really loved making it and put a lot of himself into it.
Brian's first LP video of it can be found by clicking anywhere on this entire sentence.
Enemy Support Units
I mentioned a long time ago that DT3 was going to have a group that all supported one another and mentioned a key unit in the group. That one being specifically a support unit that could heal/shield allies. This is no longer happening, but... it is happening. Instead I've repurposed that idea to be a bit more broad. In the later parts of the game, the protagonists are constantly facing off against a certain group, and within this group are various support units. Instead of having a single enemy type that can do everything and only support its squad, it can now support any ally within its faction. (Remember in the scan info, the icon that showed if it was a Mario or Zelda related enemy?)
Before this change, I was going to allow support bots to use their abilities on one another. With this more broad approach, I felt that would be a bad idea, and for science I tested it. It was rather disheartening to see a shielding bot being fully recovered by a healer when it was nearly down. Even worse though, was the healer being shielded. This constraint felt right after that.
The healers and shielders can only target a single unit at a time. Healers check all nearby units and prioritize both on the group's current HP% and a hidden value that all of that faction's enemies have. (Some of them are a hair bit more important than others.) At the time of typing this, they can heal up to 150HP/sec, but after doing more field tests, that may change. It tends to keep its target between it and the player, but it still has to be close to its target to heal.
The shielding bots can shield a single ally and make it completely invulnerable. It has no cooldown or overheat, so it's able to hold the shield indefiniately, however it has to be fairly close to its target to shield it. It isn't as active at playing 'keep-away' from the player as the healer.
There is one other type of support unit, but that one is a secret.
All support units have an auto-regeneration that (once again at the time of typing this) recover 15HP/sec.
Overexaggeration
After spending about 30 minutes trying to make an enemy that checks all of its allies HP% counts and tries to find the lowest one (which is easy), but may need to find the second or third next value, I remember that Game Maker has data structures and this could have been solved in seconds. Fuck me.
I know!
I drew a picture displaying my frustration with myself. Done in Photoshop for overkill.
DT Blog Post
Now that I've been reminded about posting a grackle video, here it is.
Map Headers
I got asked about those little window map headers that DT1 had and asked A LOT, by both the testers and all of you that played the DT3 demo if they would return.
The sentence above should tell you what happened. It wasn't till a fair ways in that I decided to put that in and you can imagine the crazy amount of maps as a backlog I suddenly had. At this point in the game, most of it was in the Gate levels as they take a large portion of the gameplay up to Chapter 16. For quite a few of the Gate and Nightmare Gate levels, I allowed the testers to add in the map quotes. They've had a big impact on the game and that seemed like a good way to let them put a bit of their voice in there.
Chapter 17 is done, so that leaves 3 more plot points to cover. Getting closer. The next level involves mountains, skies with stars, and snowballs. And some other things that have nothing to do with the rest of that.
It had some games that looked fun. That is all. Oh right, Splatoons looked really neat. I'll be following that one for awhile. I should fangasm over the Zelda trailer, but not much was shown and I don't think they'll be showing anything else during the rest of E3. I just need a little more than Link suddenly being chased down by some thingie, then turning around and going all Matrix on it with a wonky looking bow. It looks pretty at least, but I knew that would be the case.


text:
Q: Kendo NumericTextBox - prevent autocorrect when entering lower than Min value I have an ASP.NET project where I use a Kendo Numeric TextBox element. I've set a min value of 200 (in the example) and when the user enters a lower value, the input changes automatically to the min value.
Is there any way, or a property, that would enable me to avoid this and show the field in red or an error intead, rather than automatically correct to the min value?
This is my code:
@Html.Kendo()
    .NumericTextBoxFor(model => model.Example)
    .HtmlAttributes(new { style = "width: 80px;" })
    .Format("#")
    .Min(Model.MinValue)

EDIT:
I forgot to say that the min value came from a web service.

A: You can use something like this instead that will produce the same requirements you need
public class YourModel
{
   [IntegerValidator(MinValue = 200, MaxValue = int.MaxValue, ExcludeRange = true)]
   public int Example{get;set;}
}

to get more information about this idea, please check this link IntegerValidator
and you can use for example [Range(200,int.MaxValue)] for integer and [Range(200,double.MaxValue)] for double to specify only the min value
this will work with client side validation
and if you don't want to go with this idea, i think you can handle the client side event onchange for the control numerictextboxfor and you call for e.preventdefault(); and then you can handle the value as you want
hope this will help you


In Düsseldorf, queen Mathilde was awarded the "Honorary National German Sustainability Award" for her contributions to sustainable development and to humanitarian causes.
Others who received an award were musician Annie Lennox, scientist Jane Goodall and actor Marius Müller-Westernhage.
Mathilde started and ended the speech with a few phrases in German.
Wonderful look! What a dress! For the first time, the Queen wears the Wolfers tiara of the late Queen Fabiola in necklace. It's very beautiful.
Necklace and updo made a big impression with pretty gown.She looked beautiful.


text:
Public Art Comes to Life in Silverton
Silverton is a small town reinventing itself. This first-ring Cincinnati suburb has long been valued for its diversity, affordability, and small-town feel. So when Silverton village officials contacted ArtWorks about partnering with them to create the community's first public art, ArtWorks jumped at the chance.
The collaboration soon paid off.
In September 2018, ArtWorks and the village of Silverton unveiled All In This Story Together, a two-story mural at the intersection of Plainfield and Montgomery roads, serving as a gateway marker for this thriving community.
"When Silverton came to us, we could really see their vision," said Colleen Houston, ArtWorks chief programming officer. "We were excited to bring our public art expertise to partner with the residents to create something so reflective of the community's values and momentum."
The mural was designed by Cincinnati-based illustrator Erin Barker and created during the summer 2018 by ArtWorks Lead Teaching Artist Lizzy DuQuette and 5 Youth Apprentices, ages 14-21. This work represents the vibrancy and beauty of the Silverton community as shown through the colors of the mural, evoking strength and boldness, but also warmth and comfort.
Within the design, the three women figures (from the left) represent strength and resilience, ideas and growth, and creative expression. Together, these figures represent diversity and inclusivity, cooperation and togetherness, and growth through adversity. Silverton's urban forestry is shown through the linden leaves, acorn, and other foliage, while the half-circles in the bottom of the mural represent grapes, a nod to the village's history of wine making.
With the mural on the Women Writing for (a) Change building, the design includes poetic text chosen by the literary organization and through community engagement and input from community residents: "We are all in this story together" from the poem, "Tell Me, She Said," by poet and Professor Emerita of Appalachian State University Sally Atkins.
Since the mural's completion, the intersection of Plainfield and Reading has been thriving. This spring, HighGrain Brewery & Restaurant is set to open in the former municipal building and residents will be moving into a mixed-use development by The Miller-Valentine Group and Jeffrey R. Anderson Real Estate.
"Public art is part of the transformation for the village," said Tom Carroll, Silverton village manager. "Developing our master plan for Art in Public Spaces sets us up well, because extensive community input from a diverse slate of stakeholders. We have a great story here in Silverton about how public art and revitalization go hand in hand. We thank the ArtWorks team for collaborating with us to make our vision a reality."
Silverton is adding to its public art collection, commissioning a sculpture with the Kennedy Heights Art Center.
"At ArtWorks, nothing brings us more joy than to help spark creativity in a community that sees potential for public art to be a positive catalyst," Houston said. "We're honored to be part of that story for Silverton and that they trusted us to create the first piece of art in the village's master public art plan."
Thank you to the Carol Ann & Ralph V. Haile Jr./U.S. Bank Foundation for supporting ArtWorks as the 2018 Season Sponsor and to the nonprofit's ongoing funding support from ArtsWave, City of Cincinnati and Ohio Arts Council.
Call for Artists for Public Art Project
In partnership with the Kennedy Heights Art Center, the Village of Silverton invites artists to submit qualifications for a permanent piece of public art to be installed at Silverton Park. This project is the second piece of public art commissioned by the Village of Silverton and is the next step in implementing Silverton's Art in Public Places Master Plan. They are seeking artists to deliver visually bold and impactful artwork reflective of the Silverton community.
Submission Deadline: May 25, 2019
Learn more about this call for artists.
About ArtWorks
Since 1996, ArtWorks' has been transforming people and places through investments in creativity. The organization is a workforce development and job-training program where art is the vehicle that trains and employs local youth and professional talent to create art and community impact. ArtWorks has hired over 3,500 youth and 3,000 professional artists who have completed over 12,000 public and private art projects.
Photo by: Bergette Photography
Photo: J. Miles Wolf


text:
package id.franspratama.geol.core.dao;

import java.sql.ResultSet;
import java.sql.SQLException;
import java.util.List;

import org.springframework.beans.factory.annotation.Autowired;
import org.springframework.jdbc.core.JdbcTemplate;
import org.springframework.jdbc.core.RowMapper;
import org.springframework.stereotype.Repository;

@Repository("utilityRepository")
public class UtilityRepository {

	@Autowired
	JdbcTemplate jdbc;

	private static final String REGION_LIST_QUERY = "SELECT distinct region from availabilities_cluster";

	public List<String> getClusterRegion(){
		List<String> regionList = jdbc.query(REGION_LIST_QUERY,new RowMapper<String>(){

			@Override
			public String mapRow(ResultSet rs, int i) throws SQLException {
				return rs.getString("region");
			}
		});

		return regionList;
	}

}


text:
Autologous, Gene-Modified Hematopoietic Stem and Progenitor Cells Repopulate the Central Nervous System with Distinct Clonal Variants
Christopher W. Peterson, Jennifer E. Adair, Martin E. Wohlfahrt, Claire Deleage, Stefan Radtke, Blake Rust, Krystin K. Norman, Zachary K. Norgaard, Lauren E. Schefter, Gabriella M. Sghia-Hughes, Andrea Repetto, Audrey Baldessari, Robert D. Murnane, Jacob D. Estes, Hans Peter Kiem
Myeloid-differentiated hematopoietic stem cells (HSCs) have contributed to a number of novel treatment approaches for lysosomal storage diseases of the central nervous system (CNS), and may also be applied to patients infected with HIV. We quantified hematopoietic stem and progenitor cell (HSPC) trafficking to 20 tissues including lymph nodes, spleen, liver, gastrointestinal tract, CNS, and reproductive tissues. We observed efficient marking of multiple macrophage subsets, including CNS-associated myeloid cells, suggesting that HSPC-derived macrophages are a viable approach to target gene-modified cells to tissues. Gene-marked cells in the CNS were unique from gene-marked cells at any other physiological sites including peripheral blood. This novel finding suggests that these cells were derived from HSPCs, migrated to the brain, were compartmentalized, established myeloid progeny, and could be targeted for lifelong delivery of therapeutic molecules. Our findings have highly relevant implications for the development of novel therapies for genetic and infectious diseases of the CNS. Peterson, Adair, and colleagues investigated the trafficking and distribution of autologous hematopoietic stem cells and their progeny to an extensive array of tissues. Gene-marked macrophages were prominent, especially in lymphoid organs. Intriguingly, gene-marked myeloid cells in the CNS were unique from those at other sites. This observation holds great promise to therapeutically deliver disease-relevant transgenes to specific tissue sites.
Stem Cell Reports
https://doi.org/10.1016/j.stemcr.2019.05.016
cell trafficking
hematopoietic stem cells
10.1016/j.stemcr.2019.05.016
Dive into the research topics of 'Autologous, Gene-Modified Hematopoietic Stem and Progenitor Cells Repopulate the Central Nervous System with Distinct Clonal Variants'. Together they form a unique fingerprint.
Marking Chemical Compounds 100%
Hematopoietic Stem Cells Medicine & Life Sciences 72%
Central Nervous System Medicine & Life Sciences 54%
Macrophages Medicine & Life Sciences 25%
Molecule Chemical Compounds 25%
Myeloid Cells Medicine & Life Sciences 24%
Lysosomal Storage Diseases Medicine & Life Sciences 16%
Peterson, C. W., Adair, J. E., Wohlfahrt, M. E., Deleage, C., Radtke, S., Rust, B., Norman, K. K., Norgaard, Z. K., Schefter, L. E., Sghia-Hughes, G. M., Repetto, A., Baldessari, A., Murnane, R. D., Estes, J. D., & Kiem, H. P. (2019). Autologous, Gene-Modified Hematopoietic Stem and Progenitor Cells Repopulate the Central Nervous System with Distinct Clonal Variants. Stem Cell Reports, 13(1), 91-104. https://doi.org/10.1016/j.stemcr.2019.05.016
Autologous, Gene-Modified Hematopoietic Stem and Progenitor Cells Repopulate the Central Nervous System with Distinct Clonal Variants. / Peterson, Christopher W.; Adair, Jennifer E.; Wohlfahrt, Martin E.; Deleage, Claire; Radtke, Stefan; Rust, Blake; Norman, Krystin K.; Norgaard, Zachary K.; Schefter, Lauren E.; Sghia-Hughes, Gabriella M.; Repetto, Andrea; Baldessari, Audrey; Murnane, Robert D.; Estes, Jacob D.; Kiem, Hans Peter.
In: Stem Cell Reports, Vol. 13, No. 1, 09.07.2019, p. 91-104.
Peterson, CW, Adair, JE, Wohlfahrt, ME, Deleage, C, Radtke, S, Rust, B, Norman, KK, Norgaard, ZK, Schefter, LE, Sghia-Hughes, GM, Repetto, A, Baldessari, A, Murnane, RD, Estes, JD & Kiem, HP 2019, 'Autologous, Gene-Modified Hematopoietic Stem and Progenitor Cells Repopulate the Central Nervous System with Distinct Clonal Variants', Stem Cell Reports, vol. 13, no. 1, pp. 91-104. https://doi.org/10.1016/j.stemcr.2019.05.016
Peterson CW, Adair JE, Wohlfahrt ME, Deleage C, Radtke S, Rust B et al. Autologous, Gene-Modified Hematopoietic Stem and Progenitor Cells Repopulate the Central Nervous System with Distinct Clonal Variants. Stem Cell Reports. 2019 Jul 9;13(1):91-104. https://doi.org/10.1016/j.stemcr.2019.05.016
Peterson, Christopher W. ; Adair, Jennifer E. ; Wohlfahrt, Martin E. ; Deleage, Claire ; Radtke, Stefan ; Rust, Blake ; Norman, Krystin K. ; Norgaard, Zachary K. ; Schefter, Lauren E. ; Sghia-Hughes, Gabriella M. ; Repetto, Andrea ; Baldessari, Audrey ; Murnane, Robert D. ; Estes, Jacob D. ; Kiem, Hans Peter. / Autologous, Gene-Modified Hematopoietic Stem and Progenitor Cells Repopulate the Central Nervous System with Distinct Clonal Variants. In: Stem Cell Reports. 2019 ; Vol. 13, No. 1. pp. 91-104.
@article{0242b4d8dd344f7981517ef09457f2fa,
title = "Autologous, Gene-Modified Hematopoietic Stem and Progenitor Cells Repopulate the Central Nervous System with Distinct Clonal Variants",
abstract = "Myeloid-differentiated hematopoietic stem cells (HSCs) have contributed to a number of novel treatment approaches for lysosomal storage diseases of the central nervous system (CNS), and may also be applied to patients infected with HIV. We quantified hematopoietic stem and progenitor cell (HSPC) trafficking to 20 tissues including lymph nodes, spleen, liver, gastrointestinal tract, CNS, and reproductive tissues. We observed efficient marking of multiple macrophage subsets, including CNS-associated myeloid cells, suggesting that HSPC-derived macrophages are a viable approach to target gene-modified cells to tissues. Gene-marked cells in the CNS were unique from gene-marked cells at any other physiological sites including peripheral blood. This novel finding suggests that these cells were derived from HSPCs, migrated to the brain, were compartmentalized, established myeloid progeny, and could be targeted for lifelong delivery of therapeutic molecules. Our findings have highly relevant implications for the development of novel therapies for genetic and infectious diseases of the CNS. Peterson, Adair, and colleagues investigated the trafficking and distribution of autologous hematopoietic stem cells and their progeny to an extensive array of tissues. Gene-marked macrophages were prominent, especially in lymphoid organs. Intriguingly, gene-marked myeloid cells in the CNS were unique from those at other sites. This observation holds great promise to therapeutically deliver disease-relevant transgenes to specific tissue sites.",
keywords = "cell trafficking, central nervous system, hematopoietic stem cells, integration site analysis, macrophages, microglia",
author = "Peterson, {Christopher W.} and Adair, {Jennifer E.} and Wohlfahrt, {Martin E.} and Claire Deleage and Stefan Radtke and Blake Rust and Norman, {Krystin K.} and Norgaard, {Zachary K.} and Schefter, {Lauren E.} and Sghia-Hughes, {Gabriella M.} and Andrea Repetto and Audrey Baldessari and Murnane, {Robert D.} and Estes, {Jacob D.} and Kiem, {Hans Peter}",
note = "Funding Information: We thank Helen Crawford for preparing this manuscript; Veronica Nelson, Erica Curry, and Kelvin Sze for outstanding support in our pigtail macaque studies; Willi Obenza and Sowmya Reddy for processing of macaque samples; and Alexandra Ortiz, Nikki Klatt and Steve De Rosa for helpful advice regarding flow cytometry panels. This study was supported by grants from the NIH National Institute of Allergy and Infectious Diseases (U19 AI096111 and UM1 AI126623 to H.-P.K. and K.R.J.) and the National Heart, Lung, and Blood Institute (R01 HL116217 and U19 HL129902 to H.-P.K.), as well as funds from the Fred Hutchinson Cancer Research Center (to J.E.A.). This study was also supported by NIH P51 OD010425 and UW/FHCRC CFAR AI027757, and in part through the NIH/NCI Cancer Center Support Grant P30 CA015704. In addition, this project has been funded in part by the Oregon National Primate Research Center NIH grant award P51OD011092, and in part with Federal funds from the National Cancer Institute, NIH, under contract no. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. H.-P.K. is a Markey Molecular Medicine Investigator and received support as the inaugural recipient of the Jos{\'e} Carreras/E. Donnall Thomas Endowed Chair for Cancer Research and the Fred Hutch Endowed Chair for Cell and Gene Therapy. Funding Information: We thank Helen Crawford for preparing this manuscript; Veronica Nelson, Erica Curry, and Kelvin Sze for outstanding support in our pigtail macaque studies; Willi Obenza and Sowmya Reddy for processing of macaque samples; and Alexandra Ortiz, Nikki Klatt and Steve De Rosa for helpful advice regarding flow cytometry panels. This study was supported by grants from the NIH National Institute of Allergy and Infectious Diseases ( U19 AI096111 and UM1 AI126623 to H.-P.K. and K.R.J.) and the National Heart, Lung, and Blood Institute ( R01 HL116217 and U19 HL129902 to H.-P.K.), as well as funds from the Fred Hutchinson Cancer Research Center (to J.E.A.). This study was also supported by NIH P51 OD010425 and UW/FHCRC CFAR AI027757 , and in part through the NIH/NCI Cancer Center Support Grant P30 CA015704 . In addition, this project has been funded in part by the Oregon National Primate Research Center NIH grant award P51OD011092 , and in part with Federal funds from the National Cancer Institute, NIH, under contract no. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. H.-P.K. is a Markey Molecular Medicine Investigator and received support as the inaugural recipient of the Jos{\'e} Carreras/E. Donnall Thomas Endowed Chair for Cancer Research and the Fred Hutch Endowed Chair for Cell and Gene Therapy. Publisher Copyright: {\textcopyright} 2019 The Authors",
doi = "10.1016/j.stemcr.2019.05.016",
journal = "Stem Cell Reports",
publisher = "Cell Press",
T1 - Autologous, Gene-Modified Hematopoietic Stem and Progenitor Cells Repopulate the Central Nervous System with Distinct Clonal Variants
AU - Peterson, Christopher W.
AU - Adair, Jennifer E.
AU - Wohlfahrt, Martin E.
AU - Deleage, Claire
AU - Radtke, Stefan
AU - Rust, Blake
AU - Norman, Krystin K.
AU - Norgaard, Zachary K.
AU - Schefter, Lauren E.
AU - Sghia-Hughes, Gabriella M.
AU - Repetto, Andrea
AU - Baldessari, Audrey
AU - Murnane, Robert D.
AU - Estes, Jacob D.
AU - Kiem, Hans Peter
N1 - Funding Information: We thank Helen Crawford for preparing this manuscript; Veronica Nelson, Erica Curry, and Kelvin Sze for outstanding support in our pigtail macaque studies; Willi Obenza and Sowmya Reddy for processing of macaque samples; and Alexandra Ortiz, Nikki Klatt and Steve De Rosa for helpful advice regarding flow cytometry panels. This study was supported by grants from the NIH National Institute of Allergy and Infectious Diseases (U19 AI096111 and UM1 AI126623 to H.-P.K. and K.R.J.) and the National Heart, Lung, and Blood Institute (R01 HL116217 and U19 HL129902 to H.-P.K.), as well as funds from the Fred Hutchinson Cancer Research Center (to J.E.A.). This study was also supported by NIH P51 OD010425 and UW/FHCRC CFAR AI027757, and in part through the NIH/NCI Cancer Center Support Grant P30 CA015704. In addition, this project has been funded in part by the Oregon National Primate Research Center NIH grant award P51OD011092, and in part with Federal funds from the National Cancer Institute, NIH, under contract no. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. H.-P.K. is a Markey Molecular Medicine Investigator and received support as the inaugural recipient of the José Carreras/E. Donnall Thomas Endowed Chair for Cancer Research and the Fred Hutch Endowed Chair for Cell and Gene Therapy. Funding Information: We thank Helen Crawford for preparing this manuscript; Veronica Nelson, Erica Curry, and Kelvin Sze for outstanding support in our pigtail macaque studies; Willi Obenza and Sowmya Reddy for processing of macaque samples; and Alexandra Ortiz, Nikki Klatt and Steve De Rosa for helpful advice regarding flow cytometry panels. This study was supported by grants from the NIH National Institute of Allergy and Infectious Diseases ( U19 AI096111 and UM1 AI126623 to H.-P.K. and K.R.J.) and the National Heart, Lung, and Blood Institute ( R01 HL116217 and U19 HL129902 to H.-P.K.), as well as funds from the Fred Hutchinson Cancer Research Center (to J.E.A.). This study was also supported by NIH P51 OD010425 and UW/FHCRC CFAR AI027757 , and in part through the NIH/NCI Cancer Center Support Grant P30 CA015704 . In addition, this project has been funded in part by the Oregon National Primate Research Center NIH grant award P51OD011092 , and in part with Federal funds from the National Cancer Institute, NIH, under contract no. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. H.-P.K. is a Markey Molecular Medicine Investigator and received support as the inaugural recipient of the José Carreras/E. Donnall Thomas Endowed Chair for Cancer Research and the Fred Hutch Endowed Chair for Cell and Gene Therapy. Publisher Copyright: © 2019 The Authors
N2 - Myeloid-differentiated hematopoietic stem cells (HSCs) have contributed to a number of novel treatment approaches for lysosomal storage diseases of the central nervous system (CNS), and may also be applied to patients infected with HIV. We quantified hematopoietic stem and progenitor cell (HSPC) trafficking to 20 tissues including lymph nodes, spleen, liver, gastrointestinal tract, CNS, and reproductive tissues. We observed efficient marking of multiple macrophage subsets, including CNS-associated myeloid cells, suggesting that HSPC-derived macrophages are a viable approach to target gene-modified cells to tissues. Gene-marked cells in the CNS were unique from gene-marked cells at any other physiological sites including peripheral blood. This novel finding suggests that these cells were derived from HSPCs, migrated to the brain, were compartmentalized, established myeloid progeny, and could be targeted for lifelong delivery of therapeutic molecules. Our findings have highly relevant implications for the development of novel therapies for genetic and infectious diseases of the CNS. Peterson, Adair, and colleagues investigated the trafficking and distribution of autologous hematopoietic stem cells and their progeny to an extensive array of tissues. Gene-marked macrophages were prominent, especially in lymphoid organs. Intriguingly, gene-marked myeloid cells in the CNS were unique from those at other sites. This observation holds great promise to therapeutically deliver disease-relevant transgenes to specific tissue sites.
AB - Myeloid-differentiated hematopoietic stem cells (HSCs) have contributed to a number of novel treatment approaches for lysosomal storage diseases of the central nervous system (CNS), and may also be applied to patients infected with HIV. We quantified hematopoietic stem and progenitor cell (HSPC) trafficking to 20 tissues including lymph nodes, spleen, liver, gastrointestinal tract, CNS, and reproductive tissues. We observed efficient marking of multiple macrophage subsets, including CNS-associated myeloid cells, suggesting that HSPC-derived macrophages are a viable approach to target gene-modified cells to tissues. Gene-marked cells in the CNS were unique from gene-marked cells at any other physiological sites including peripheral blood. This novel finding suggests that these cells were derived from HSPCs, migrated to the brain, were compartmentalized, established myeloid progeny, and could be targeted for lifelong delivery of therapeutic molecules. Our findings have highly relevant implications for the development of novel therapies for genetic and infectious diseases of the CNS. Peterson, Adair, and colleagues investigated the trafficking and distribution of autologous hematopoietic stem cells and their progeny to an extensive array of tissues. Gene-marked macrophages were prominent, especially in lymphoid organs. Intriguingly, gene-marked myeloid cells in the CNS were unique from those at other sites. This observation holds great promise to therapeutically deliver disease-relevant transgenes to specific tissue sites.
KW - cell trafficking
KW - central nervous system
KW - hematopoietic stem cells
KW - integration site analysis
KW - macrophages
KW - microglia
U2 - 10.1016/j.stemcr.2019.05.016
DO - 10.1016/j.stemcr.2019.05.016
JO - Stem Cell Reports
JF - Stem Cell Reports


text:
Harold "Clayton" Bowser of Lynn died Sunday September 26, at the Hospice House of Lincoln.
Born in Weymouth, October 3, 1937, he was the son of the late Harold C. and Mary (Cassidy) Bowser.
Clayton was raised in Somerville He served in the Army during the Vietnam Era where he served 2 tours of duty. Following the war he moved to Washington D.C. and spent over 20 years selling fish directly off the boat. Upon his return to Massachusetts he worked as a Security Guard in Boston.
He was the brother of the late Richard Bowser and Joan Jackson. Uncle of Janice Ross of Salem and Jeffery Jackson of Boston. He is survived by two grandnephews: Paul McGrath and Ryan Ross, both of Salem and one grandniece, Ramina McGrath also of Salem; also survived by several cousins.
A Graveside Service will be held at the Lakeside Cemetery, North Ave., Wakefield on Saturday at 11AM. Relatives and friends are invited to attend. Arrangements by the McDonald Funeral Home, Wakefield.
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text:
Singing show tunes helps fight off dementia, Alzheimer's disease: study
By DAVID HARDING
Julie Andrews from 'The Sound of Music.' Researchers found singing along with show tunes helped seniors with dementia.
The hills are alive with the sound of music, which could help people with Alzheimer's stave off the effects of the debilitating disease.
A study by U.S. scientists has shown that the brain function of those suffering from dementia can be improved if they belt out their favorite show tunes.
Researchers working with elderly residents at an East Coast care home found in a four-month long study found that people who sang their favorite songs showed a marked improvement compared to those who just listened.
Among the songs sung during 50-minute sessions were hits from "The Wizard of Oz," "Oklahoma!" and "The Sound of Music."
The most improvement was among those sufferers with moderate to severe dementia.
A scene from the musical 'Oklahoma!' Seniors who participated in a show tunes sing-along showed improvement in their memory skills.
Jane Flinn, one of the scientists involved in the study who works at George Mason University in Virginia, concluded singing was beneficial.
"Even when people are in the fairly advanced stages of dementia, when it is so advanced they are in a secure ward, singing sessions were still helpful," she said.
"The message is: don't give up on these people. You need to be doing things that engage them, and singing is cheap, easy and engaging."
Amount the songs sung were "Somewhere Over the Rainbow," "The Sound of Music" and When You Wish Upon A Star," reported the Guardian.


1) Minutes of February 14 were reviewed and accepted.
working the issue of a new web statistics report.
digital camera.  Bob will lead exhibit but needs additional helpers.
session to get it operational.  Ben and Bob agreed to a Friday afternoon.
City (Ray Pecora) will help.
letters from the IRS will be scanned and added to our web site.
7) Julie Kasper will represent the City at our April 11 meeting.
Submitted on April 8, 2002 by Bob Ekman.