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Re3gistry
Re3ference platform
Reusing INSPIRE
INSPIRE Reference Validator and Interoperability Testing
INSPIRE Reference Validator - How to develop tests for the new common INSPIRE validator
Video: How to develop tests for the new common INSPIRE validator
Lorena HERNANDEZ
What is this video about?
After a period of testing at JRC and with interested validation experts, version 1.0 of the common INSPIRE validator was released and presented in a workshop during the 2017 INSPIRE Conference. The current version of the validator covers tests forÑ
the INSPIRE TGs on metadata (v1.3),
download services (Atom and WFS) and
Annex I data themes.
In order to arrive at a complete INSPIRE test framework, additional tests need to be developed, e.g. for the new version (2.0) of the metadata TGs, view services, Annex II+III themes and other download service options (SOS, WCS). Also, some Member States or thematic communities may want to add their own tests on top of the existing ones.
A webinar took place on Monday, 3rd of July 2017 to inform stakeholders about the current status of the validator and to introduce the steps necessary for developing additional tests to be added into the INSPIRE test framework.
If you would like to try out the validator and provide your feedback, please feel free to contact us at are3na@jrc.ec.europa.eu and visit the INSPIRE Validation GitHub repository (https://github.com/inspire-eu-validat...)
The supporting slides are available here.
The INSPIRE Directive (http://inspire.ec.europa.eu/) entered into force in 2007, establishing an infrastructure for spatial information. Given the generic nature of the Directive, Implementing Rules that must be adopted by the Member States together with Technical Guidelines that help Member States to comply with these Implementing Rules have been developed. To help implementers of INSPIRE to test conformance, the European Commission has decided to develop one single Test Framework to overcome discrepancies in conformance testing across Member States. This common validator will help to overcome the drawback of having incompatible test results over different test frameworks from country to country by standardising the testing process. Furthermore, it will also help implementers of INSPIRE to test conformance and develop solutions which are validated as INSPIRE compliant using a single, official and common validation process. This will result in an optimisation of efforts when it comes to the development of INSPIRE compliant geolocation solutions.
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I was alerted to this call to action by Travis Rummel of Felt Soul Media. Check out his post on The Wire. My request - Make your voice heard on the issue of mining law reform. Time is short (10/31). Click on this link for more information - I CAN HELP. My thoughts - Watersheds are directly affected by mining. Keep in mind that all the material that comes out of pits like the ones shown has to go somewhere. What does the mining industry track record for resource protection look like? What is the real economic benefit picture? Are pits in the earth due to extraction "needs" really the best thing for the planet? For us? We're talking long term impacts on a mother nature level. Ain't no gettin' the mountain back....or the river. I ask - Do something unusual, call your Representative and tell them to vote for HR2262, the Hardrock Mining and Reclamation Act of 2007 or you can find your Representative's contact information and send them an email HERE. My opinion - The Mining Law Act of 1872 is arguably the worst case of corporate welfare in our nation's history. If it's after hours you can still call your reps D.C. office and leave a message, TELL THEM TO VOTE YES ON HR2262.
Bottom - The Grasberg Mine in Indonesia is the current #1 open pit mine for total mineralization value in the world. The Pebble deposit looks to be larger in total value and will soon surpass Grasberg in total mineralization value. Pretty $cary.


Our theme at OneCamp this year is "MORE". In Job 36:26, it says "God is great, we do not know Him, and the number of His years is unsearchable." Basically it translates to, God is big, you don't know Him as well as you think you do, and you're never going to figure Him. You'll never get all there is to understand from God. So that is what we are centering OneCamp on this summer.
Our worship at OneCamp 2019 will be led by a collection of talented worship leaders from all across our Network.
Attached are a few details we feel you will find helpful to make your students camp experience the best it can be. Please read over them carefully and if you have any questions, please do not hesitate to ask!
Identity in Christ - "Who am I?" "Who gets to decide who I am?" "Is it genetic or up to me?" "What am I supposed to do with my life?" These are the basic questions of life. Identity in Christ helps build a foundation for answering them.
Hearing God's Voice- We believe God is speaking to all of us, but it can be hard to figure out when and how God speaks to us. This is an opportunity to learn how to identify the voice of God in our lives and tools to use to encounter God in new ways.
Old Testament in Light of Jesus- In reading the Old Testament through the lens of Jesus, we see through unveiled eyes the true beauty in the ancient texts. We find Jesus within stories of the Bible that can be frustrating, confusing, and challenging.
Calming Storms- We all have our breaking points. As stressful situations build in our lives, we can choose to crumble or soar. It's easier to fade into darkness and separate ourselves into deeper loneliness. Instead of relief and escape, we sometimes find brick walls, mounting waves, more emotional pain, and helplessness. This is not God's plan for us. There is always a way out, and God has not left you or abandoned you. You were created to thrive, not drown.
Worship 101 The Who, What, When,Why, & Where- Learn what it means to worship and discover that we become the most genuine and unique versions of ourselves as we worship.
Abundant Thought Life- God cares about your thoughts, worries, and the things stressing you out and He loves you more than you can possibly imagine. Come learn how Jesus gives you power and authority to silence lies and negative thoughts in order to believe truth in your mind. He wants to set you free so you can have an abundant thought life filled with more love, hope, healing, peace, and joy.
Living on Mission- Do you feel called to be a missionary but you're under 18 so you can't move out of the country? Do you wonder how you're supposed to apply Jesus teachings in a world that doesn't work by the same rules? Living on Mission will help you address these issues and more.
Please leave cell phones at home. Any cell phone brought to camp will be taken up by cabin leaders and returned at the end of the week. Phones are available at Mobley Hall anytime for free calls home. Parents may reach their children by calling 770-786-6926 (Emergencies only, please!!!) We do this because we desire our students to have a week that is set apart and we know that cell phones can be a huge distraction. Thank you for your understanding.
Male campers must stay on the male side of the camp and females on the female side of camp. Male campers are never allowed in female cabins, and vice versa.
At worship, campers sit by gender-boys on left, girls on right!
All clothing must be modest. Girls – please bring a modest one-piece or tankini (midsection must be covered when arms are raised) swimsuits, only. Shorts should be modest in length. Tops should not have spaghetti straps, razor back, or be halter style and should cover your stomach - no bare midriffs. Swimsuits are not allowed to be worn in the dining hall. Pajama pants should NOT be worn outside of the cabin. Boys – shorts should be modest in length. Shoes must be worn at all times…except in the pool and in bed! Tennis shoes are encouraged to prevent falls! PLEASE use your best judgment in packing for camp. Camp counselors will ask campers to change into appropriate clothing if necessary.
The buses are $30 for round trip transportation this year. You must reserve a spot and pay for transportation prior to June 15. This year you will have the option to ride the bus to camp ($15) and then the option to ride the bus back to RiverStone ($15).
Plan to arrive at the camp between 3-4 p.m. on Sunday, June 30th. Please do not arrive any earlier or later. Camp closes at 11:30 a.m. on Friday, July 5th, and campers will NOT be allowed to leave early. Parents should arrive before 11:30 a.m. on July 5th if camper is not riding the bus home.
**Rising college students may drive to camp but they are to leave car keys with their cabin leaders upon arrival to camp. No other students may drive to camp.
Take I-75 South to I-20 East. Go east on I-20 to Exit #93.
All check-in will be done at Riverstone Church prior boarding the buses.
Report all medical conditions or issues with the nurse at RiverStone during check-in. This will give us a chance to meet you and discuss any questions we may have.
Please be sure to bring a copy of your insurance card with you and turn it in at check-in at RiverStone.
A completed Medical Release MUST be on file prior to loading the bus.
Upon arrival to camp (between 3 and 4 PM), you will be given directions to the Dining Hall to check-in.
Report all medical conditions or issues with the nurse. This will give us a chance to meet you and discuss any questions we may have.
A completed Medical Release must be received in order to attend camp.
Please bring a copy of your insurance card with you and turn it in at check-in in the Dining Hall.
Each evening we schedule awesome activities such as a color rave, dance party and pool party! As we get closer to Camp, we will send out information regarding special items to bring like clothes to get messy in, white clothing for the color rave or special themed items.
Don't forget to bring necessary equipment (guitars, tennis racquets, etc.) for the Leisure Groups you signed up for. Photographers … you may bring your camera but you will be responsible for it during camp. **We try to honor all leisure group requests, but some groups may be full, and we will assign you to a similar group if possible. Leisure groups cannot be changed at camp!!
You may want to bring extra spending money for snacks and beverages available during free time. Our "Resource Center" is returning this year, in which CD's, books, journals, t-shirts, track bags, etc. will be available for sale.
Parents are invited to attend our evening worship services. We will let you know our worship schedule as we get closer to Camp.
Follow us leading up to camp…and parents keep on following us once your student is at camp! We will use the hashtag #onecamp2019 !!!
Registered nurses will be at camp. They will dispense all medications, treat illnesses and camp emergencies. Over-the-counter medications that will be available in the infirmary are Aspirin, Tylenol, Motrin, Aleve, Claritin, Benadryl, Neosporin, Kaopectate.
Our morning teaching time this year will be led by David Eldridge, Pastor of Stonebridge Church. David is a brilliant speaker, and we are thankful for his willingness to invest in our students.
"Morning Thing" is our game time together each morning. Get your game faces on and be ready for lots of fun!
Teaching Impact Groups are topically based groups where students can choose what they want to hear about that day. Each of the teaching impact groups is centered on our theme and designed to help us live the life God is calling us to live. There are 8 teaching impact groups students self-select when signing up for OneCamp. Each is designed with a focus on helping students see how they can more effectively pursue God's mission in each arena of their lives.
We understand that camp may be difficult for parents and students to pay for, so we strive to help as much as we are able to. If you are in need of help, please apply for financial assistance as soon as possible. We have instituted a payment plan option for registering your student this year. Each church is also handling their own scholarships so please contact your network church. If you are not connected to one of our network churches please visit www.1camp.org and click the Camp Info, Financial Aid tab.
All remaining balances for camp are due by Friday, June 22nd. Camp fees are not refundable after camp begins!
We're here to hear you!


"Thank you for my light shade, it is lovely. I will be back for more. "
Equinox outdoor lighting by Endon is perfect for lighting up walk ways or garden paths. Finished in stainless steel it not only looks great but is practical at the same time.


If you've got an interest in the structure and mechanics of materials – and you're ready to help tackle the geotechnical problems posed by large-scale construction – our MSc Civil Engineering with Geotechnical Engineering degree course is for you.
On this course, you'll expand on your knowledge and experience of the core disciplines of civil engineering and develop the analytical and technical skills - such as ground investigations and soil structure testing - needed to solve geotechnical problems.
When you graduate, you'll be ready to take on ambitious roles in your career – whether that's in the civil engineering and geotechnical engineering industries, or in the related fields of mining and petroleum and environmental consultancy.


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Scientific Design > 1-Science News > Life sciences > Life Sciences August 2022
September 7, 2022 September 4, 2022 scientist
Articles on cloning, DNA nanomotors, totipotent cells, black bear serum's effects
Cloning two seemingly healthy baby beagle puppies
Korean company ToolGen has for the first time combined CRISPR-Cas9 technology and cloning to produce two seemingly healthy baby beagle puppies. The technology could also contribute to the safeguarding and conservation of biodiversity, by applying it to species threatened with extinction.
First electric nanomotors made from DNA
Researchers have developed the world's first electric nanomotors made from DNA. Specific strands added to a solution result in self-assembled structures that can be activated by an electrical charge that drives a rotor arm.
Transform cells into totipotent stem cells
A new cocktail of drugs makes it possible to transform the cells which are exposed to it into totipotent stem cells, at the level of the transcriptome, the epigenome and the metabolome, They can differentiate into any cell in the body, which makes it possible to circumvent the need for sperm and eggs to develop an organism.
New "synthetic embryos"
Scientists grew "synthetic embryos" from mice cells without using sperm, eggs, or a womb. they were 95 percent similar to normal mouse embryos and had grown a placenta and the beginnings of a spine and brain, a digestive tract, a beating heart. However, these are not "real" embryos able to grow to term when they were put in a mouse uterus.
Black bear serum to cure human muscles
Exposure of human muscle cells to the serum produced by black bears during hibernation would not only prevent the atrophy of these tissues but would also promote an increase in their mass. A particular factor blocks the destruction mechanism at the origin of muscle degradation, which normally occurs when these are not used for a prolonged period.
– Life sciences articles

redpajama_set_name: RedPajamaCommonCrawl


How about an adventure into the deep sea. The online Under the Sea slot machine is your gateway to that experience. It has rewarding standard play icons. The wild and scatter offer outstanding benefits. With as much as fifteen free spins and a reward that is eight times your investment, could there be a better deal? Add to that a 400 coin worth jackpot and two precious bonus features.
The default configuration includes thirty pay lines. You could pick all thirty lines and place one two cent coin on each. That accumulates to sixty cents in one round. On the higher end, the coin is valued at $1. Therefore, activating all lines at that denomination equals to a mere $30 on one spin. It makes the game affordable and convenient.
Blonde lady – get five of them on your reels and you are credited with 400 coins. One less and you still earn 200 coins to your account.
Green Fish – this is the second most precious one among them all with a gift of 300 coins for five of the icons.
Yellow fish – get five of these yellow earners and you are given 200 coins to gamble.
Try the popular Double Diamond slot machine with jackpot.
The wild. The wild is the pearl. It rewards with several multipliers sometimes as much as eight times your bet.
The scatter. Stated as the scatter icon, the ship is responsible for ferrying you free spins. Apart from extra turns, it also grants the player a 2x multiplier for their wins.
Treasure Chest. Get three of these, and you are welcomed to another game. In the new section, you get to pick treasures which are then credited to your account balance.
If you are more of a mobile gadgets guy than the desktop or you just need a little more flexibility, Betsoft has you covered. They have designed a mobile compatible version for this game. Compared to the original desktop intended model, you cannot tell the difference except the obvious one. That the screen sizes have changed.
Like the parent model, the mobile derivative gives the Under the Sea slot no download & registration needed option to play. As long as you are connected to the internet, you can begin to play instantly. Both Apple and Android supported devices are eligible to play the game. The software has been redesigned for compatibility and adaptability.
A straightforward and fast way to play is what characterizes the slot game. Think of it as the easiest yet most fascinating adventure into the deep ocean. The first step is to pick your coin size. Whether you prefer the minimal two cents denomination or higher to $1, all are available. After you decide on what bet you will apply on each line, you are at liberty to add as many coins to the selected lines. However, only five coins are allowed per line.
The function of the auto play button is to ease the entire preparatory process. Therefore, instead of going through the above steps, you just click the button. The pop-up window lets you configure your setup, and that will be used until you decide to change it. If you choose to aim for the jackpot, then select the maximum bet button.
The lowest number of free spins offered is eight which is given in exchange for three ship symbols. Five ships reward fifteen turns. Apart from just free spins, two ships on the reels regardless of their placement rewards with a doubling of your bet. Thus, you get a double offer of extra turns and a 2x multiplier.
The Pearl. This feature is allowable through the wild symbol. For just one pearl, your wins are doubled. Two pearls quadruple your earning while three make sure you have eight times what you staked in the round.
The Treasure Pick. To access the treasure game, you must have three treasure chests. Once you are in, you just pick a chest, and it reveals your prize.
The Jackpot Priz. The jackpot is non-progressive. That would be a setback were the reward from it not as good. Winning the award here means you earn yourself 400 coins. That is no small amount compared to what other non-progressives offer. Plus, you get to play Under the Sea for free with no download and registration.


There are also various other ways of paying (by the minute, or by pre-paying certain amounts in advance) and there are discounts for Nerja residents if their cars are taxed in Nerja (so expats with foreign registered cars, or people with cars registered in other towns don't get the discount).
could not agree more . just got back dont mind paying but there prices are way too high.
We don't drive to Nerja anymore. We have an apartment right next to the entrance to this car park, and we used to stay in Nerja for approx 3-4 months at a time.
Parking is often impossible now on the streets around there, and the car park is far too expensive for the duration of our stay.
Pity, but they have priced us out of Nerja now, unfortunately.


As the pioneer in using Peltier technology for thermal ovens, Memmert now enters new dimensions with their brand new HPP1400. With an interior volume of almost 1400 litres, the constant climate chamber is the largest available device of its kind without using energy-intensive compressors and conventional heating elements.
Based on its outstanding precise homogenous temperature stability and the quiet operation, the new XXL climate chamber is perfectly tuned for stability tests according to ICH, GMP or the IFSCC regulations, amongst others.
Even when fully loaded, the temperature and humidity remain stable and evenly distributed in the entire chamber. Despite the large volume, recovery and response time for heating and cooling to set temperatures are pleasantly fast.
Active humidity control, minimised water consumption.
The new Memmert HPP1400 is working within a temperature range to +60°C. Equipped with a digitally controlled active humidification and dehumidification from 10% to 80% rH, water consumption is noticeably reduced. Needless to say, all parameters (temperature and humidity) are logged, in compliance with FDA regulations.


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Wat Phrathat Doi Suthep (in lingua thai: วัดพระธาตุดอยสุเทพ) è un tempio del Buddhismo Theravada nella Provincia di Chiang Mai, in Thailandia del Nord. Il tempio è spesso indicato come "Doi Suthep" anche se questo è in realtà il nome della montagna su cui è situato. Si trova a 15 km dalla città di Chiang Mai ed è un luogo sacro per molti thailandesi. Dal tempio è possibile ammirare una spettacolare vista su Chiang Mai, è quindi una popolare meta turistica.

Altri progetti

Collegamenti esterni

doi suthep

redpajama_set_name: RedPajamaWikipedia


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The Internet Society is a non-profit organization that has considerable influence, predominately in standards, public policy, and education. At their 20th anniversary annual meeting in Geneva, The Internet Society added a new award.
Congratulations to the 2012 inductees into the Internet Hall of Fame!
Take a few moments and visit the Hall of Fame Website. The nominations are very impressive with the incredible impact they have had on the Internet, its development and growth.
Pioneers Circle
Recognizing individuals who were instrumental in the early design and development of the Internet: Paul Baran, Vint Cerf, Danny Cohen, Steve Crocker, Donald Davies, Elizabeth Feinler, Charles Herzfeld, Robert Kahn, Peter Kirstein, Leonard Kleinrock, John Klensin, Jon Postel, Louis Pouzin, and Lawrence Roberts.
Recognizing individuals who made outstanding technological, commercial, or policy advances and helped to expand the Internet's reach: Mitchell Baker, Tim Berners-Lee, Robert Cailliau, Van Jacobson, Lawrence Landweber, Paul Mockapetris, Craig Newmark, Raymond Tomlinson, Linus Torvalds, and Philip Zimmermann.
Global Connectors
Recognizing individuals from around the world who have made significant contributions to the global growth and use of the Internet: Randy Bush, Kilnam Chon, Al Gore, Nancy Hafkin, Geoff Huston, Brewster Kahle, Daniel Karrenberg, Toru Takahashi, and Tan Tin Wee.☺
Hot Tip: Save Your Computer from Power Surges
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La Querciona, detta anche Quercia gigante, è un albero monumentale situato in località Baratti-Populonia nel comune di Piombino.
Si tratta di un esemplare di roverella (Quercus pubescens). Ha una circonferenza del tronco di 4,45 m ed è alto 30 m.

Storia
È iscritto nella lista degli alberi monumentali della Toscana e nel 2007 ha ricevuto il Premio Touring Club, riconoscimento indetto dai consoli TCI della Toscana per gli alberi monumentali.

Note

Collegamenti esterni

Alberi monumentali della Toscana
Piombino
Querce monumentali


text:
Mohamed Mazhar Abdel Rahman (born 11 November 1976) is an Egyptian former professional footballer who played for AS Monaco and the Egypt national football team

International goals

References

External links

1976 births
Living people
Egyptian footballers
Egypt international footballers
Egyptian expatriate footballers
Al Mokawloon Al Arab SC players
Al Masry SC players
AS Monaco FC players
LB Châteauroux players
Jiangsu F.C. players
Ligue 1 players
Expatriate footballers in France
Expatriate footballers in China
China League One players
Association football forwards


In CCI, alongside co-counselling, we have Here and Now Groups: I have been going to these groups for 20 years, both inside and outside the CCI network, and continue to be enthusiastic about how the situation provides me with the opportunity to be surprised, to get to know myself, to relate instead of switching off, and to connect with myself and others authentically and in unexpected ways.
Stay in the here and now, to stay present, and notice your thoughts and feelings.
Try to avoid talking about 'there and then'.
This is an exploratory group with no fixed agenda: allow space for the unexpected.
Experience a group of equals where there is no leader to show you what to do: the group is peer-led.
It's not a discussion space for ideas about the world or about other people, it's about "what is": it's about "being".
Group meetings have a beginning and an end time, plus time for a break, but other than that have no structure, so as to allow an open space for the participants to use as they wish: there is no set task or division of roles.
The experience is both interpersonal and intra-personal. This means that there is an element of relating to others in the group, so it is inter-active, but it also provides an opportunity for internal reflection, about how you are, in any one moment.
At times there may be silence in the group broken only when someone feels moved to speak.
Here and now groups are different to but complementary to co-counselling. At the CCI network residential events (there are about 12 per year in the UK which you may optionally attend) we primarily do workshops that are straightforward co-counselling, which follow the basic method that we have been using for decades, and that you can learn by doing the course advertised on this site. However, alongside this, we often have at least a couple of workshop spaces at each residential dedicated to the Here and Now Group structure.
I also put on Here and Now groups in Leeds.
and you are responsible for your own wellbeing. The group is not suitable for people who are very emotionally fragile or disturbed, nor for anyone whose life is in chaos. It should be fine for you as long as you welcome the opportunity to reflect on how you are in the present moment, and can tolerate the fact that we won't know what will be said. Whilst it may help you if you have had some experience of group-work, this is not essential.


This session was moderated by Martin Bwalya, Co-chair, Global Alliance for Climate-Smart Agriculture (GACSA), who opened by stating livelihoods are important, policymakers cannot afford to ignore land and "we cannot fight nature" when it comes to agriculture.
Martin Frick, Director, Climate Energy and Tenure Division, FAO, said "COP 21 is the most adaptation focused COP we have ever had." He noted that virtually all Intended Nationally Determined Contributions (INDCs) mention agriculture or food security in one way or another, a fact he called "heartening." He highlighted that if policymakers don't act now there could be a reduction in crop yields of 18% in Sub-Saharan Africa by 2030.
Frank Rijsberman, CEO, CGIAR, emphasized the need for win-win solutions for adaptation and mitigation and highlighted a recently launched initiative on soil carbon as a good example since soil carbon helps agriculture and also reduces greenhouse gases (GHGs). He stated that there is a desperate need for dynamic agricultural practices and for more innovation and research to achieve this.
Anette Friis, Knowledge Action Group (KAG), GACSA, highlighted the work of the KAG and said stakeholders determine its focus, for instance on providing the knowledge that policy makers need to make decisions.
Discussion ensued on inter alia: the role of climate-smart agriculture and technology; priority setting for the technical working groups of GACSA; the role of youth in GACSA and its inclusive nature; strengthening local farmer associations and including them in GACSA; availability of resources to support climate-smart agriculture; and building capacity of smallholder farmers to co-create solutions with scientists.
Isabelle Coche, Vice-President Strategy, Emerging Ag Inc.
This session focused on innovation in climate-smart agriculture and was opened by Michael Hailu, Director, CTA. He lamented agriculture is not featured prominently within the COP 21 negotiations, but said more than 60% of countries do include agriculture in their INDCs which is promising. The challenge, he said, is to determine what kind of innovations will contribute to creating and scaling up climate resilient agriculture in Africa.
James Kinyangi, Regional Program Leader, CCAFS, said agriculture in Africa must be wholly transformed. When proposing an agricultural solution to climate change, he said, it is essential to be wary of the concomitant deforestation that comes with bringing new land into production. As a risky business, he said, agriculture presents tremendous challenges to the hundreds of millions of smallholder farmers in Africa. He noted that different organizations advocate for conflicting approaches, for example, the UN Development Programme prefers an agro-ecological approach compared with the UN Environment Programme which has advocated for an ecosystem based approach.
Aida Diongue Niang, Director, National Agency for Civil Aviation and Meteorology, Senegal, focused her remarks on the close linkage between agricultural productivity and weather. In Senegal, she said, although agriculture employs 60% of people the country has a very short rainy season. She displayed charts demonstrating wide inter-annual variation in rainfall in Senegal between 2013-2015 and noted the difficulty this creates for farmers. To solve this, she discussed the implementation of seasonal weather forecasts at the local scale that provide information about the best crops to be sown. In addition she showcased a "now-casting" system that informs farmers of imminent weather events by text message and suggests precautions to be taken with regards to livestock and crops.
Delali Kofi Nutuskpo, Representative, Council for Scientific and Industrial Research, discussed the need for more stakeholder participation in agricultural policymaking in order to target investments, focusing on the case of Ghana. He said that decentralized systems are crucial in that they help allocate responsibilities based on priorities at each level in the system, be it local, regional or national.
Achiba Gargule, CEO, Agency for Rangelands, Information and Development, began by noting the importance of livestock to farmers and underscored drought is the most pervasive hazard for livestock production in East Africa. He discussed index insurance, which is an alternative to traditional insurance in that it provides security if rains don't come. When a drought hits a pastoralist area, he said, the first thing farmers do is to sell livestock immediately, driving everything to the market. Index insurance reduces this type of "distressed selling" by 36%, he said, and also reduces the likelihood that families will eat less during a drought.
Oladimeji Oladele, Professor of Agricultural Extension, North-West University, presented on the importance of developing "agroweather tools" using the case of a pilot project in Ethiopia and Kenya. Such tools, he said, are based on a decision support system that combines historical data with geo-reference data to predict the distribution, intensity and availability of rainfall. Because the rate of phone subscription is rising, he said, information is released by SMS text messaging and is both prescriptive and advisory, telling farmers the actions to take during 10 day forecast periods. He noted that the project naturally incorporates sellers of agricultural inputs because it represents a new means for them to market their products in a targeted way that provides positive results to farmers.
Isabelle Coche, Vice-President Strategy, Emerging Ag Inc., said the private sector can bring knowledge, solutions, tools and technologies but that it is limited when governments do not have strong regulatory frameworks to help match supply of solutions with demand.
Bernard Rey, Director General for International Cooperation and Development, EC, recognized the need for more investment in agriculture to feed the world and said there is a need to address risk and that public goods must be safeguarded when scaling up investment. He highlighted four major objectives to pursue, including: eliminating malnutrition, making agriculture an engine of livelihood growth, empowering farmers to manage their landscapes and ecosystems, and building resilience to food crises among farming communities.
This session was moderated by Muawia Shaddad, President, HoA-REC, and focused on climate-smart agriculture, integrated land use and low carbon development in the Horn of Africa countries.
Almaz Tadesse, Deputy Director, Social and Ecological Sustainability Partnership Programme, HoA-REC, presented the Integrated Land-use and Development Plan for the Gambella Region of Ethiopia that is focused on an area with high bio-cultural diversity. She noted that there are two primary interventions, namely the creation of the Plan itself and also a biodiversity management programme. She said the approach they are taking will focus on bottom-up planning by stakeholders rather than top-down planning for them.
Adane Kebede, Climate Change Programme Coordinator, HoA-REC, presented on the landscape approach and climate-smart agricultural practices in the Gambella EcoHub and Central Rift Valley. He noted that projects are operating in six landscapes in countries throughout the Horn of Africa. He stated they are taking a multi-level and multi-sectoral approach, engaging stakeholders and promoting ecosystem based integrated development and climate-smart agriculture. He highlighted that the Gambella EcoHub is a learning and demonstration site for sustainable agriculture practices and value chains of production that can go hand in hand with conservation efforts.
Haile Fisseha, General Manager, Addis Ababa City Administration, Ethiopia, presented on Addis Ababa's waste management and light rail systems. He explained the plans to transform an open landfill in Addis Ababa into a science park and to utilize landfill waste in a waste-to-energy facility that will open in late 2015 and that can generate 50 gigawatts of energy to meet one-third of the city's energy demand. He also outlined the city's light rail transit system that is already operational and noted plans to enhance the road network.
Chukwumerije Okereke, Professor, University of Reading, emphasized the need for Africa to "retool its understanding of what has to happen" with regards to development and to develop the agricultural sector, which is one of Africa's comparative advantages, by mobilizing the youth and the skills available. He highlighted that adaptation is a global issue as livelihood loss and environmental degradation can lead to migration. He outlined that the role of debt is not mentioned in the negotiations at COP 21 and noted that due to debt-repayment obligations "Africa is not receiving but giving aid to the West." He argued that the lack of an overarching mechanism for dealing with capacity building in the UNFCCC is a "major blind spot." He also highlighted that if international property rights are not clearly addressed then the implementation of climate-smart agriculture could perpetuate colonialism and tie African countries to multinational corporations based in the North.
Fitsumbrhan Tsegaye, Sustainable Energy Programme, HoA-REC, highlighted that the waste management program in Addis Ababa is a flagship program that helps Ethiopia towards green development and noted that Addis Ababa has applied to be a part of the 100 Resilient Cities Challenge.
Discussions ensued on: whether Ethiopia, with its plan to cut 20% of emissions by 2030 primarily using its own financing, is the best example for Africa; and how African countries can leverage knowledge from each other.
This session presented the details of three programmes in Ethiopia, Rwanda and The Gambia designed to strengthen meteorological capacity, observing networks, early warning systems and data and information management.
Tom Owiyo, ClimDev-Africa Special Fund, AfDB, opened the session noting the three programmes are innovative because they were developed in close consultation with the countries themselves. Climate information services, he said, is an area that governments do not typically prioritize in their budgets. He underscored that the programmes have been able to improve significantly on traditional modeling that provides data at a resolution of only 50 kilometers and can now reach resolutions at detail of up to 1 kilometer. It is important, he said, to convince governments to invest in climate data networks that go beyond serving the aviation sector and reach out to smallholder farmers and the energy sector.
Pa Ousman Jarju, Minister of Environment, Climate Change, Forestry, Water and Wildlife, The Gambia, said data at the global level, such as that disseminated by the IPCC, is important, but there is need to downscale to regional and local level data. Traditionally, meteorological data is collected every three hours, but now, he said, the government can provide up-to-date and accurate information to end users on-demand. He underscored that Africa is a continent that depends almost 80% on agriculture for livelihoods. Thus, he said, information on both weather and market conditions is crucial. Farmers, he said, must be able to know when to grow, what to grow and in which areas.
Ato Teshome, Director, National Meteorological Agency, Ethiopia, emphasized the role of partnerships in going beyond national budgets to improve: human capacity, database systems and technology in meteorological data networks. He said Ethiopia currently has only 147 automatic weather stations and that the country must somehow scale up to 700. He noted the challenges of scanning and digitizing historical meteorological data and improving regional meteorological centers. He highlighted successes made in partnership with ClimDev-Africa including access to new datasets, improved capacity for data digitization and improved capacity at branch meteorological offices.
Alpha Jallow, Department of Water Resources, The Gambia, discussed an early warning project in his country that uses 10 automatic weather stations in combination with human observations to provide data for a variety of end users. He emphasized that accurate data is important but useless if it is not in an accessible format.
Faustin Munyazikwiye, UNFCCC Focal Point, Rwanda, presented about the Technical Support Programme to Rwanda on climate and hydrology, a Programme in collaboration with UNECA. The Programme's ultimate objective is to provide investment and technical support to improve the hydrological observation and data management systems in Rwanda. The Programme helped to develop a baseline climate vulnerability index, he said.
Andre Kamga Foamouhoue, Project Manager, ACMAD, said ACMAD is focused on ensuring climate information for adaptation is high quality. ACMAD organizes regional climate outlook forums in the African sub regions, he said, to support discussions on future investments in climate services in Africa. During a brief discussion, participants hailed Clim-Dev Africa as the common thread running through all three of the featured programs.


text:
Small Wars by Sadie Jones
The conflict becomes a war in which, "…there was no truth. It was a nothing, laughable Mickey Mouse conflict; it was a sinister time of terror and repression. The British were misguided and ignorant; the Cypriots were lethargic and foolish. The Cypriots loved the British; the Cypriots hated the British. The British were torturers; the British were decent and honourable. EOKA were terrorists; EOKA were heroes."
John R. Guthrie
Small Wars: A Novel
by Sadie Jones
Harper, 384 pp.
CLR [rating:4.5]
A British Soldier and His Family in War-torn Cyprus
Major Hal Treherne and wife Clara share the spotlight in novelist Sadie Jones's well-told tale, Small Wars. Major Treherne, a 1946 Sandhurst graduate, is a rising star in Her Majesty's Army. He is idealistic and determined to be, like his father and grandfather before him, an honorable soldier and a credit to the armed forces and the nation. In 1955 he reports in for duty with British Forces on Cyprus near the village of Episkopi on the island's southern coast. The small town of Limassol is adjacent to the base.
Clara follows by ship with their twin nineteen-month old daughters, Meg and Lottie. Through novelist Jones's eyes, we see Major Treherne as a soldier/father/husband who loves Clara and the children. Clara encounters austere circumstances for herself and the twins including being generally unable to communicate with the locals and residing in miserably substandard off-base housing. With admirable British resilience, she makes the most of her difficulties, happy for the family to be together again.
Cyprus, because of its location, has a long and colorful history, one that is often written in blood. The island is 200 by 100 miles, slightly larger than half the size of Connecticut, and is shaped like a pollywog sprouting legs. Its Eastern Mediterranean locale is in close proximity to Turkey, Syria, Lebanon, Egypt, and Greece. Significantly for British interests, it stands on the approach to the strategically important Suez Canal and thus to the oil-rich Middle East in general.
Cyprus's larger community is of Greek descent. There is also a smaller demographic of Turkish Cypriots, remnants of the once far-ranging Ottoman Empire.
The Greek Cypriots wanted union with Greece, "enosis." The Brits reneged on a promise to consent. Members of the Greek community organized EOKA (a Greek acronym for National Organisation of Cypriot Fighters). In 1955 they began a brutal campaign of terror that lasted well into 1956 against the British.
The miniscule war quickly became, "…a thing driving itself with no absolutes to unravel. Places that are fought over will always be fought over…and there will never be an end to it, and each conflict is just adding to the heap of conflicts that no one can remember starting and no one will ever, finish."
Terrorism, the weapon of the weak against the mighty, is seen to be similar in its manifestations no matter the locale or the cause: pipe bombs, random shootings and more ensue. Inevitably, as Treherne's commanding officer Colonel Burroughs notes, in the retaliation by British forces in Limassol, "Some of the men had been understandably overzealous." Such overzealousness is, of course, a part of the terrorist's goal; it helps them in recruiting locals.
Major Treherne's initiation into combat occurrs when he leads a search and destroy mission into the island's interior to capture or kill the terrorist Pappas. Cyprus's beaches are idyllic, the interior terrain mountainous. The peaks and valleys of the interior are not as imposing as those of, say, Afghanistan, yet they can be equally barren and forbidding. Treherne's orderly, Kirby, aptly characterized the terrain they searched as follows, "Who'd be prepared to die for this?…It's just rocks.'" Major Treherne realizes the landscape is, "…enormous, foreign to all of them, and daunting. That to their enemy it was home and friendly as a pasture." The encounter with Pappas and his men culminates in a fierce and brutal encounter in a remote mountain redoubt.
The furor becomes so intense that Hal insists that Clara and the children move to ostensibly safer quarters in the city of Nicosia; "…practically Paris compared to Limassol."
The separation proves stressful for Clara. Her distress intensified by the fact that she is, quite unintentionally, four months pregnant. Her loneliness is assuaged in some degree by developing a friend and supporter in the person of Gracie Bundle, another "stiff upper lip " army wife and the mother of four young boys. Yet even in cosmopolitan Nicosia, far from the sound of the bugle's call, neither Gracie nor Clara find safety from the uncertainties and dangers of their "Small War."
Over the final seventy or so pages of this story, novelist Jones continues to build suspense as she deftly knits together a surprising resolution for Major Hal Treherne and his family. Subsequent decisions and actions by Major Treherne in dealing with his, his family's and his command's circumstances are dismaying—but well told and provocative. The yet unvoiced buzz phrase, Post Traumatic Stress Disorder, aptly summarizes his state of mind.
Jones plots her story with exceptional skill, effectively breathing life into her characters. Her prose is spare, fluid, and provides a sense of verity as she artfully demonstrates the impact of Cyprus's, "Small War," on the Treherne family and others.
Small Wars gives the thoughtful reader something to carry away, to consider, after the book is finally closed. With its constant threat of terrorist incidents, the uncertainty and the emotional toll of the conflict, this novel possesses a remarkable contemporary resonance. It is unlikely for any reader to leave Small Wars without giving some thought to our men and women in uniform in Middle East locations such as Afghanistan.
This work of literary fiction is also notable for its psychological depth and characterizations. The shortcomings of Small Wars are quibbles. Jones has the archaic and impedimentary habit of abbreviating military units with initial letters and blanks, e.g. R_____ A_____. This breaks the flow of the read because it's difficult not to stop and attempt to decipher the blanks. She refers to the plane that evacuates Clara Treherne as, "Not a (twin-engine) Valetta after all, but a twin-engine Hastings." The Hastings is a four-engine late 1940s work-horse designed for troop transport, innovative for that era and a machine of which the British were justifiably proud.
Sadie Jones resides in London with her husband and two sons. Her debut novel, The Outcast was published to wide critical acclaim in 2008. It received both the British Costa Award for a first novel and was also nominated for the coveted Orange Prize. In the United States it was a finalist in the Los Angeles Times Book Prize for First Fiction. One can reasonably expect similar high regard for Small Wars.
John R. Guthrie is a former Marine infantry rifleman. He later studied medicine and became the commanding officer of a U.S. Navy Reserve Shock Surgical Group. He practiced family medicine in the Smoky Mountain foothills of Appalachia. His fiction, poetry, and nonfiction has been published widely. He is the editor and publisher of the monthly webzine "The Chickasaw Plum: Politics and the Arts Online." Tianjin Grand Bridge
Related Topics:Cyprus, Sadie Jones
John R. Guthrie is a former Marine infantry rifleman. He later studied medicine and became the commanding officer of a U.S. Navy Reserve Shock Surgical Group. He practiced family medicine in the Smoky Mountain foothills of Appalachia. His fiction, poetry, and nonfiction has been published widely. He is the editor and publisher of the monthly webzine "The Chickasaw Plum: Politics and the Arts Online." Tianjin Grand Bridge
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text:
Part II Information Statement
Under Part II of the Freedom of Information Act 1982, the Judicial College of Victoria is required to publish an information statement on its operations. The statement provides information on what we do, the kinds of documents we hold, and how a person can request access.
View Information Statement
Judicial College of Victoria
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Telephone: 61 3 9032 0555
info@judicialcollege.vic.edu.au
The Judicial College of Victoria acknowledges the Traditional Owners of the land across Victoria. We pay our respects to their Elders, past, present and future.
© 2019 Judicial College of Victoria


Jerry Dammers of the legendary Specials. So proud of this one, to meet someone responsible for so much that I loved as a kid is the true privilege of this job. His music and politics were wonderfully intertwined in a way that made both stronger and the shoot I hope reflected this love and respect. A lovely addition to the experience was a shout from Supersize Art who created the Gangsters 7" replica that makes this image work so well, framing Jerry behind. Morgan Howell's art is astonishing and well worth hanging in your own home. Such a find.


text:
HomeNewsMediaFootballChina
Shinai lands exclusive Women's World Cup digital rights in China
China's players celebrate their 3-2 victory over South Korea in the 2022 AFC Women's Asian Cup final (by Thananuwat Srirasant/Getty Images)
Shinai, the company that operates sports streaming platform iQiyi Sports, has acquired exclusive digital media rights in China to the 2023 Fifa Women's World Cup.
The agreement with world football's governing body is Shinai's first for a Fifa competition. Shinai will provide all 64 matches in the mainland of China, with exclusive free-to-air broadcast rights to the Women's World Cup still available for the region.
2023 Fifa Women's World Cup
Chinese trading card company Daka adds Belgium football team to portfolio
Venue switch mooted for Australia's Women's World Cup opener
Australia's opening match at this year's Women's World Cup, which it will co-host with New Zealand, is set to move from Allianz Stadium to Accor Stadium to ensure a higher attendance for the fixture. A
Fifa Women's World Cup passes 500,000 ticket sales, with 1.5m the target
More than 500,000 tickets have been sold for this year's Fifa Women's World Cup in Australia and New Zealand, leaving organisers with just under one million to go to reach a previously-stated target


Virtual reality creators' community Kaleidoscope has announced the winning projects of its 2016 Kaleidoscope World Tour Awards. Showcasing the best in VR film, art and immersive experiences, the World Tour traveled to numerous major cities around the globe, including Paris, London, Stockholm, Berlin, Amsterdam, Pangyo, Tokyo and Melbourne. The show was produced in association with WIRED and powered by Wevr Transport.
The Grand Prize for excellence in cinematic VR went to Mike Tucker's Tana Pura. Additional awards went to James George & Jonathan Minard's Clouds (Best Documentary), Pierre Friquet's Jet Lag (Best Live Action Experience), Tyle Hurd's Old Friend (Best Animated Experience), Balthazar Auxietre's La Peri: A Prelude (Best Interactive Experience), and Notes on Blindness by Arnaud Colinart, Amaury La Burthe, Peter Middleton & James Spinney (Best Experimental Experience).
The winners were selected by an international committee and will receive over $50,000 worth of donated products, services and software from sponsors Wevr, Nokia, G-Technology, SubPac, Unity, Skullcandy, Samsung, Nvidia and SideFX.
With more than 4,000 attendees, the Kaleidoscope World Tour unearthed some surprising insights about the nascent VR entertainment industry. "The movement is global, it's growing faster than anyone thinks, and the most interesting work is being produced by independent artists," said Kaleidoscope co-founder René Pinnell. Audiences had the opportunity to enjoy the full lineup of experiences on Gear VR equipment supplied by Samsung, as well as the Oculus Rift and HTC Vive VR headsets. In addition, experiences were exhibited using the newly launched Wevr Transport, ensuring beautiful playback and a seamless user experience.


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APBA1 Bos taurus
APBA1 Canis lupus familiaris
apba1a Danio rerio
APBA1 Gallus gallus
Apba1 Mus musculus
APBA1 Pan troglodytes
Apba1 Rattus norvegicus
apba1 Xenopus (Silurana) tropicalis
Homology information is based on Homologene.
Homologues
NCBI Gene
NCBI SNP
iHOP resource
Disease relevance of APBA1
Psychiatry related information on APBA1
High impact information on APBA1
Chemical compound and disease context of APBA1
Biological context of APBA1
Anatomical context of APBA1
Associations of APBA1 with chemical compounds
Physical interactions of APBA1
Regulatory relationships of APBA1
Other interactions of APBA1
Analytical, diagnostic and therapeutic context of APBA1
Gene Review:
APBA1 - amyloid beta (A4) precursor protein...
Synonyms: Adapter protein X11alpha, Amyloid beta A4 precursor protein-binding family A member 1, D9S411E, LIN10, MINT1, ...
Rosowsky, A. et al., Bécamel, C. et al., Okamoto, M. et al., Almas, K. et al., Li, N. et al., et al.
Miller, McLoughlin, Lau, Tennant, Rogelj, Tanahashi, Tabira, Witt, Ramji, Gibb, Dunavent, Flood, Barnes, Russo, Faraonio, Minopoli, De Candia, De Renzis, Zambrano, Almas, Skaug, Ahmad,
Sporadic serrated adenomas had significantly more frequent methylation of MINT1 (48%, 10 of 22) and MINT2 (71%, 15 of 21) than tubular adenomas (9%, 3 of 34, P = 0.001; and 18%, 6 of 34, P = 0.0001), respectively [1].
A single isolate from a patient with fatal typhoid fever had a unique X11 profile, while four of six isolates from patients with severe typhoid fever had the X1 pattern [2].
Palatal erythema in patients using Listerine Cool Mint PocketPaks Oral Care Strips: case reports [3].
Corsodyl, Alprox, Oral-B advantage, Florosept, Sensodyne, Aquafresh Mint, Betadine and Emoform mouthrinses were used while 50% aqueous extract of miswak (Salvadora persica) was used against Streptococcus faecalis, Streptococcus pyogenis, Streptococcus mutans, Candida albicans, Staphylococcus aureus and Staphylococcus epidermidis [4].
Three cell systems (MINT1/2/3) derived from a melanotic neuroectodermal tumor of infancy (MNTI) arising in the mandible of a 1-month-old newborn boy have been established, and their cytological natures have been characterized [5].
X11 alpha and X11 beta are two neuronal adaptor proteins that interact with the Alzheimer's disease amyloid precursor protein (APP) [6].
Mutations in genes encoding components of the highly conserved MALS/CASK/Mint-1 complex cause presynaptic defects [7].
The X11 proteins, Abeta production and Alzheimer's disease [8].
The same CD2 antibodies that were mitogenic in the presence of PMA (9.6, X11, VIT13), but not the nonreactive ones, were also able to induce T cell proliferation via the so-called alternative pathway of T cell activation, i.e., when added pairwise in certain combinations to T cells in the absence of PMA [9].
Methylation of p16 and hMLH1 promoters was determined by methylation-specific polymerase chain reaction (PCR), whereas methylation at MINT 1, 2, 12, and 31 loci was assessed by bisulfite PCR [10].
These proteins include several synaptic multidomain proteins containing one or several PDZ domains (PSD95 and the proteins of the tripartite complex Veli3-CASK-Mint1), proteins of the actin/spectrin cytoskeleton and signalling proteins [11].
Bacteria in dental plaque were decreased by exposure to Listerine, Cool Mint Listerine, and povidone iodine for 30 seconds [12].
Facilitation of stress-induced phosphorylation of beta-amyloid precursor protein family members by X11-like/Mint2 protein [13].
This latter effect was associated with a reduced Mint binding affinity in one mutant, implying a potential mechanism for the observed alteration in release kinetics [14].
Dense methylation of the 5' CpG island of DAP kinase and MINT1 was well correlated with loss of gene expression [15].
Hippocampal slice electrophysiology uncovered a decline in spontaneous neurotransmitter release, lowered synaptic strength, and enhanced paired-pulse facilitation in Mint-deficient mice, suggesting a decreased presynaptic release probability [16].
Here we describe additional barriers to clonal expansion (Mint) intermediate between M1 and M2, revealed by abrogation of tumor-suppressor gene (TSG) pathways by individual human papillomavirus type 16 (HPV16) proteins [17].
Mint 1 and 2 are proteins that bind to munc18-1, an essential component of the synaptic vesicle fusion machinery, and are detectably expressed only in neurons [Okamoto and Südhof, J. Biol. Chem. 272, 31459-31464 (1997)] [18].
Mint 3 is ubiquitously expressed in all tissues, with lowest levels in brain and testis whereas mint 1 and 2 appear to be brain-specific [18].
This proteolytic activity was not affected by soybean trypsin inhibitor but was strongly inhibited by the tBP esters of GMCHA, APAA, and APBA, their effects roughly paralleling their inhibitions of the growth of HeLa cells [19].
Follow-up appointments suggest an allergic contact focal erythema caused by prolonged contact with the irritant, in this case due to use of Listerine Cool Mint PocketPaks Oral Care Strips [3].
The phosphotyrosine binding domain of the neuronal protein X11alpha/mint-1 binds to the C-terminus of amyloid precursor protein (APP) and inhibits catabolism to beta-amyloid (Abeta), but the mechanism of this effect is unclear [20].
Similar chemistry starting from methyl D,L-2-amino-4-(diethoxyphosphinyl)butanoic acid and methyl N delta-(benzyloxycarbonyl)-L-ornithinate yielded D,L-2-[(5-deaza-5,6,7,8-tetrahydropteroyl)amino]-4-phosphonobut ano ic acid (5-dH4Pte-APBA) and N alpha-(5-deaza-5,6,7,8-tetrahydropteroyl)-L-ornithine (5-dH4PteOrn), respectively [21].
In contrast, Orn and APBA analogues obeyed competitive inhibition kinetics and were more potent, with Ki values as low as 30 nM [21].
Maalox MS Cool Mint and ES Gaviscon were the least palatable [22].
The mature protein consists of 71 amino acid residues arranged in six 12- or 13-mer repeats with a consensus sequence consisting of Cys-Thr-X3-Ser-X5-X6-Cys-X8-X9-Ala-X11-Thr-X1 3, where X3 and X11 tend to be charged residues, X5 tends to be Thr or Ser, X6 to be Asn or Asp, X9 to be Asn or Lys and X13 to be Ala in the 13-mers [23].
X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains [6].
We have found that the X11 PI domain binds a YENPTY motif in the intracellular domain of (beta)APP that is strikingly similar to the NPXY motifs that bind the Shc and IRS-1 PI/PTB domains [24].
We conclude that Munc18a acts through direct and indirect interactions with X11 proteins and powerfully regulates APP metabolism and Abeta secretion [25].
XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms [26].
The small size of the APP cytodomain and the overlapping of its regions involved in the binding of Fe65 and X11 suggest the existence of competitive mechanisms regulating the binding of the various ligands to this cytosolic domain [27].
Methylation of MINT1 and MINT31 also correlated with poor prognoses (P = 0.058 and 0.041), whereas methylation of p14ARF correlated with a good prognosis (P = 0.021) [15].
Unlike other members of the X11 protein family, X11L2 mRNA was expressed in various tissues [28].
Coimmunoprecipitation experiments showed that 5-HT(2C) receptors interact with PSD95 and the Veli3-CASK-Mint1 complex in vivo [11].
Using site-directed mutagenesis, we have identified a crucial residue within the PI domain involved in X11 and FE65 binding to (beta)APP [24].
CIMP status was investigated by examining the methylation status of MINT1, MINT2, MINT12, MINT25 and MINT31. p53 mutation status was examined by PCR-single strand conformation polymorphism and promoter methylation status was examined by methylation-specific PCR [29].
A double-blinded, 3-period, 6-sequence crossover study was conducted evaluating the antiplaque effect of the novel 0.07% high bioavailable, alcohol-free CPC rinse versus a positive control (Listerine Cool Mint containing essential oils) and a negative control (placebo CPC rinse) [30].
The hearing aids used were the NHS BE19 and the Lavis X11 [31].
Frequent CpG island methylation in serrated adenomas of the colorectum. Park, S.J., Rashid, A., Lee, J.H., Kim, S.G., Hamilton, S.R., Wu, T.T. Am. J. Pathol. (2003) [Pubmed]
Increasing genetic diversity of Salmonella enterica serovar typhi isolates from papua new guinea over the period from 1992 to 1999. Thong, K.L., Goh, Y.L., Yasin, R.M., Lau, M.G., Passey, M., Winston, G., Yoannes, M., Pang, T., Reeder, J.C. J. Clin. Microbiol. (2002) [Pubmed]
Palatal erythema in patients using Listerine Cool Mint PocketPaks Oral Care Strips: case reports. Pham, C.L., Wood, A.J., Lambert, M.B., Carpenter, W. Journal of dentistry for children (Chicago, Ill.) (2005) [Pubmed]
An in vitro antimicrobial comparison of miswak extract with commercially available non-alcohol mouthrinses. Almas, K., Skaug, N., Ahmad, I. International journal of dental hygiene. (2005) [Pubmed]
Establishment and characterization of new cell lines derived from melanotic neuroectodermal tumor of infancy arising in the mandible. Metwaly, H., Cheng, J., Maruyama, S., Ohshiro, K., Suzuki, I., Hoshina, Y., Saku, T. Pathol. Int. (2005) [Pubmed]
X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains. Lau, K.F., McLoughlin, D.M., Standen, C., Miller, C.C. Mol. Cell. Neurosci. (2000) [Pubmed]
Synaptic transmission regulated by a presynaptic MALS/Liprin-alpha protein complex. Olsen, O., Moore, K.A., Nicoll, R.A., Bredt, D.S. Curr. Opin. Cell Biol. (2006) [Pubmed]
The X11 proteins, Abeta production and Alzheimer's disease. Miller, C.C., McLoughlin, D.M., Lau, K.F., Tennant, M.E., Rogelj, B. Trends Neurosci. (2006) [Pubmed]
T cell stimulation via the erythrocyte receptor. Synergism between monoclonal antibodies and phorbol myristate acetate without changes of free cytoplasmic Ca++ levels. Holter, W., Fischer, G.F., Majdic, O., Stockinger, H., Knapp, W. J. Exp. Med. (1986) [Pubmed]
CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability. Hawkins, N., Norrie, M., Cheong, K., Mokany, E., Ku, S.L., Meagher, A., O'Connor, T., Ward, R. Gastroenterology (2002) [Pubmed]
Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach. Bécamel, C., Alonso, G., Galéotti, N., Demey, E., Jouin, P., Ullmer, C., Dumuis, A., Bockaert, J., Marin, P. EMBO J. (2002) [Pubmed]
Bactericidal effects of mouth rinses on oral bacteria. Kasuga, Y., Ikenoya, H., Okuda, K. Bull. Tokyo Dent. Coll. (1997) [Pubmed]
Facilitation of stress-induced phosphorylation of beta-amyloid precursor protein family members by X11-like/Mint2 protein. Taru, H., Suzuki, T. J. Biol. Chem. (2004) [Pubmed]
Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions. Ciufo, L.F., Barclay, J.W., Burgoyne, R.D., Morgan, A. Mol. Biol. Cell (2005) [Pubmed]
Aberrant methylation of multiple genes and clinicopathological features in oral squamous cell carcinoma. Ogi, K., Toyota, M., Ohe-Toyota, M., Tanaka, N., Noguchi, M., Sonoda, T., Kohama, G., Tokino, T. Clin. Cancer Res. (2002) [Pubmed]
Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family. Ho, A., Morishita, W., Atasoy, D., Liu, X., Tabuchi, K., Hammer, R.E., Malenka, R.C., S??dhof, T.C. J. Neurosci. (2006) [Pubmed]
Control of replicative life span in human cells: barriers to clonal expansion intermediate between M1 senescence and M2 crisis. Bond, J.A., Haughton, M.F., Rowson, J.M., Smith, P.J., Gire, V., Wynford-Thomas, D., Wyllie, F.S. Mol. Cell. Biol. (1999) [Pubmed]
Mint 3: a ubiquitous mint isoform that does not bind to munc18-1 or -2. Okamoto, M., Südhof, T.C. Eur. J. Cell Biol. (1998) [Pubmed]
Inhibition of growth of HeLa cells by new synthetic protease inhibitors. Mori, S., Kozaki, Y., Kato, M., Tendo, A., Kikawa, Y., Sekine, H., Muramatu, M. J. Biochem. (1984) [Pubmed]
X11alpha impairs gamma- but not beta-cleavage of amyloid precursor protein. King, G.D., Cherian, K., Turner, R.S. J. Neurochem. (2004) [Pubmed]
Side chain modified 5-deazafolate and 5-deazatetrahydrofolate analogues as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: synthesis and in vitro biological evaluation. Rosowsky, A., Forsch, R.A., Reich, V.E., Freisheim, J.H., Moran, R.G. J. Med. Chem. (1992) [Pubmed]
Comparative palatability of 22 liquid antacids. Temple, M.E., Nahata, M.C. Aliment. Pharmacol. Ther. (2000) [Pubmed]
Enhancement of insect antifreeze protein activity by solutes of low molecular mass. Li, N., Andorfer, C.A., Duman, J.G. J. Exp. Biol. (1998) [Pubmed]
The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein. Borg, J.P., Ooi, J., Levy, E., Margolis, B. Mol. Cell. Biol. (1996) [Pubmed]
Synergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolism. Ho, C.S., Marinescu, V., Steinhilb, M.L., Gaut, J.R., Turner, R.S., Stuenkel, E.L. J. Biol. Chem. (2002) [Pubmed]
XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms. Sumioka, A., Imoto, S., Martins, R.N., Kirino, Y., Suzuki, T. Biochem. J. (2003) [Pubmed]
Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor protein. Russo, T., Faraonio, R., Minopoli, G., De Candia, P., De Renzis, S., Zambrano, N. FEBS Lett. (1998) [Pubmed]
X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein. Tanahashi, H., Tabira, T. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
Frequent epigenetic inactivation of RIZ1 by promoter hypermethylation in human gastric carcinoma. Oshimo, Y., Oue, N., Mitani, Y., Nakayama, H., Kitadai, Y., Yoshida, K., Chayama, K., Yasui, W. Int. J. Cancer (2004) [Pubmed]
Antibacterial and antiplaque effects of a novel, alcohol-free oral rinse with cetylpyridinium chloride. Witt, J., Ramji, N., Gibb, R., Dunavent, J., Flood, J., Barnes, J. The journal of contemporary dental practice [electronic resource]. (2005) [Pubmed]
Insertion gain measurements using two low-powered analogue hearing aids. Norman, M., James, P. British journal of audiology. (2000) [Pubmed]


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Provide comfort for the family of Katherine Guidry with a meaningful gesture of sympathy.
Funeral Services will be held Saturday, February 9, 2019 at 2:00 P.M. in the Duhon Funeral Home Chapel in Rayne for Katherine M. "Kathy" Guidry, 80, who passed away on Wednesday, February 6, 2019 at 7:36 A.M. at Southwind Nursing Home in Crowley.
Deacon Dennis Lacroix, from St. Joseph Catholic Church will be officiating for the services. Burial will be held in St. Joseph Catholic Church old Cemetery in Rayne at a later date.
The family has requested the visitation to be held on Saturday at 9:00 A.M. until time of services all in the Funeral Home Chapel in Rayne. A Rosary will be recited on Saturday at 1:30 P.M.
Survivors include two sons, Donald Wold, Jr. of Lake Charles, Troy and wife, Stacie Guidry of Cypress, TX; one sister, Betty Morgan Thevis of Rayne; one brother, Weldon Joseph Morgan of Port Barre; five grandchildren, Bryan Wold, Santana Wold, Bailey Rosas, Madison Guidry and Peyton Guidry; three great-grandchildren.
Ms. Guidry was preceded in death by parents, Archie and Amanda Dupont Morgan; one son, Scott Anthony Guidry; one sister, Melba Morgan Mizell; three brothers, Milton "Sonny" Morgan, Edmund Leroy Morgan, and James "Jimmy" Morgan.
Katherine's family would like to thank the staff of Southwind Healthcare and Rehabilitation for the loving care of Katherine Guidry.
You may view the obituary, sign the guest registry and express condolences online to Ms. Guidry's family at www.duhonfuneralhome.com.
Billy, Patsy, Richard and Cecelia Morgan purchased flowers for the family of Katherine Guidry.


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