Secure networking provider PureVPN and their customer base were the target of an attack over the weekend that hinged upon a critical zero-day vulnerability in client management WHMCS's product versions 5.2.7 and 5.1.9 which was disclosed last week, for which exploits have already been distributed in the wild.
"The vulnerability allows an attacker, who has valid login to the installed product, to craft a SQL Injection Attack via a specific URL query parameter against any product page that updates database information," WHMCS stated in a security bulletin.
The vulnerability allowed the attackers to send a faux email to PureVPN's clients stating the company was ceasing operations due to legal entanglements, and that all of the company's customer private data was surrendered to authorities.
"This morning some of our users have received a fake email and we are putting this blog post as a clarification. We are NOT closing down nor do we have outstanding legal issues of any sort. We have neither been contacted by any authorities nor do we store our user's personal data to share with anyone," said Uzair Gadit, Co-founder, in a blog post.
"Our VPN service is functioning 100% fine and there is no interruption whatsoever. While we are investigating the cause of the email, we reemphasize that, as we do not store any of our users credit card nor PayPal information in our on-site databases, there has been no compromise in our users billing information… We are able to confirm that the breach is limited to a subset of registered users Email IDs and names," and update stated.
"In wake of the hack attempt we have been continuously testing our systems for any further possible security lapses. It been more than 36 hours now since the incident and we want to reassure our valued users that all systems including the Client area, Billing Systems, Support center as well as all the systems of the VPN service including the VPN servers are functioning 100% well," a third update stated.
No reports have been made of their being other victims of a similar exploit, and a patch for the vulnerability can be found here.


It's November and I'm posting a pumpkin recipe.
Firstly, November. Who let that happen people? I demand an answer. Because I'm almost certain that the last thing I remember was tumbling through July and landing with an almighty crash at the end of August. I've only just recovered from the shock of realising that we were half way through the year when – I mean really.
I'm posting a pumpkin recipe and it's almost Christmas.
(In some parts of America, I'm sure this would be sacrilege).
I cooked and ate a pumpkin recipe.
It's no secret in many of my dining circles that orange vegetables and I don't get along. Â And by "don't get along", I really mean, "really quite despise each other".
My roast dinners of past are usually characterised by a double serving of peas. No carrot. No sweet potato. Certainly not any pumpkin.
But then, a couple of years ago, I got to thinking about this little prejudice of mine. Â I was eating an eggplant and mushroom something (who knows what it was) and recalling a time when neither of the two were permitted to so much as touch my plate, let alone cross my palate. And I decided it was time to try harder.
I winced through kumera chips (too sweet, oddly orange).
I nibbled on carrot crudite (too sweet, blunt crunch, oddly orange).
I speared a sole cube of thyme-flecked roast pumpkin from a salad (too sweet, mushy, oddly orange).
And then thought of giving up.
But I didn't, and many a carrot-flecked bowl of fried rice later, I'm getting there.  Whilst I'm not quite up to reveling in the delicious golden sweetness of honey roasted carrots (far too sweet, far too orange), I will eat a couple of carrot sticks where the celery is all gone, and I'll try that strange, bright, sugary, starchy mess that is parading itself as a potato and something-orange mash next to my otherwise properly coloured meal.
More than that, I've finally tried making the infamous pumpkin scone. (For a non-pumpkin scone, check this recipe out).
And (horror of horrors) liking them.
There's also the added bonus of not having to rub a whole heap of butter into a whole heap of flour. Which is my most disliked step in scone making.
Apart from having to touch and eat pumpkin. Of course.
1. Sift the self raising flour and spices into a bowl.
2. Add the remaining ingredients and mix briefly to combine.
3. Once a dough starts to form, pat it out into a round about 3-4cm thick and cut out rounds.
4. Place the rounds in a baking tin so that they are touching each other. Â This will help the scones to rise. Brush the tops with milk to help them become golden.
5. Bank in a 200C oven for 15 minutes. Â You can check to see if they're cooked by tapping them – they will feel firm and the sound will be more of a "dok dok" than a "thud dud". Â (I have no idea if anyone understood that last instruction, but I'm going to cross my fingers and hope for the best).
yums! (: that sound awesome! never had pumpkin scones before! im sure they are yummy!
I've heard about this orange prejudice of yours! And although I'm not entirely anti-orange, I do share issues of not being entirely chummy with sweet potato or pumpkin either…but we are learning to live with each other.
Scones are a all-season food so doesn't matter what you put in them!
And yayyyy, now you can venture more into the world of orange yes yes?
Lovely scones, Shez! Orange is the colour!
Pumpkin and sweet potato are my faves! You're strange for not liking them =p Haha these scones do sound oh so lovely though! 2 certain websites keep showing pumpkin recipes which makes me want to do something with pumpkin other than roasting or mashing it.
I had to laugh as I read this. I don't have orange veggie hate to the extent that you do; but ever since I was eight I have firmly believed that the only proper use for pumpkins is in pumpkin scones!


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Food/Beverages/Tobacco
Tilray's stock surges after deal that extends lock up of shares held by largest shareholder
Published: June 10, 2019 6:55 a.m. ET
Shares of Tilray Inc. TLRY, +2.03% shot up 8.2% in premarket trade Monday, after the Canada-based cannabis company announced an agreement that extends the lock up, and provide for the orderly sale, of the 75 million shares, or 77% of the Tilray shares outstanding, held by its largest shareholder, Privateer Holdings. Inc. Under terms of the letter of intent, Privateer will merge with a wholly-owned subsidiary of Tilray, with Privateer stockholders receiving newly issued Tilray shares equal to the number of Tilray shares currently held by Privateer. Once the merger is completed, all Tilray shares held by Privateer will be cancelled. The Tilray shares distributed in the merger will be subject to a lock-up agreement that allows for the sale of shares "only under certain circumstances" over a two-year period. "During the first year following the closing of the merger, shares will be released only pursuant to marketed offerings and/or block trades to institutional investors or via stock sales to strategic investors, all of which would be arranged at the sole discretion of Tilray," Tilray said in a statement. "The remaining shares will be subject to a staggered release over the course of the second year following closing." Tilray's stock has tumbled 44.6% over the past three months through Friday, while the S&P 500 SPX, +0.02% has gained 4.8%.
TLRY
Tilray Inc. Cl 2 U.S.: Nasdaq: TLRY

redpajama_set_name: RedPajamaCommonCrawl


text:
, född 10 maj 1995 i Chiba prefektur, är en japansk fotbollsspelare.

Asakawa började sin karriär 2018 i YSCC Yokohama. Han spelade 32 ligamatcher för klubben. 2020 flyttade han till Roasso Kumamoto.

Källor

Japanska fotbollsspelare
Spelare i YSCC Yokohama
Spelare i Roasso Kumamoto
Födda 1995
Levande personer
Män
Personer från Chiba prefektur

redpajama_set_name: RedPajamaWikipedia


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Cash My Guns: Prices and Trends in Gun Collecting
Selling your guns can be a hard decision. Maybe you're looking to upgrade your gun collection. Perhaps you're looking to retire or hoping for some extra cash. Perhaps you've inherited a valuable gun or gun collection and don't have an interest in the genre or enough storage space on hand. There are countless reasons why people decide to cash their guns, and the option is especially appealing given the current uptrend in vintage gun prices and the unprecedented popularity of the classic firearms market as a whole.
A Serial Number 10 Belgian Military Trials FN High-Power Pistol blew away its high estimate in August 2022 and sold for $44,063 with Rock Island Auction Company.
Why should I Cash my Guns?
Nearly all gun genres are in hot demand right now, with gun prices going up across the board. Fine arms collecting has seen ever-increasing interest at auctions and local gun shows, and online gun collecting communities and popular YouTube channels have introduced a whole new generation of shooters and arms enthusiasts to the pursuit. That means thousands of new customers every year who are willing to pay to enter the market, and recent prices at Rock Island Auction Company reflect this enthusiasm.
For vintage and collectible firearms, consigning with Rock Island Auction Company is the best way to sell guns.
Saying this is the perfect time to cash your guns is an understatement. While some modern gun values have increased, even more dramatic upswings are evident in the antique and vintage guns genres at Rock Island Auction Company. From Civil War guns, Wild West six-shooters, and military arms from the two world wars, classic guns are enjoying their highest prices to date, and knowing when to sell is just as important as choosing where to sell when it comes to getting the most cash for your guns.
"Is now a good time to cash my guns?" With Rock Island Auction Company continuing to realize record gun prices, the answer is most definitely yes.
Where should I Cash my Guns?
When looking to cash your guns, there are numerous options to consider. While pawn shops might offer fast cash compared to an auction, they have a clear conflict of interest with the seller in that they're in business to buy your gun at the lowest possible price. Gun stores follow a similar model and usually only offer a fraction of the true gun value to a seller. There are numerous ways to sell a gun online today, but the average prices realized vary significantly from site to site, and this is often related to the size and quality of their buying audience. At Rock Island Auction Company, you're partnering with a business that wants the highest possible price for your gun.
Rock Island Auction consistently brings in the most money for gun consigners, particularly for classics like the Colt Single Action Army.
When it comes to getting the most cash for your firearms, Rock Island Auction Company has a proven record of success. The guns are cataloged before each auction, beautifully photographed, and marketed widely across online and traditional channels, reaching tens of thousands of potential bidders around the world. This gives gun sellers the widest reach in the industry and translates to record gun sales year after year. The truth is in the numbers.
"What's the best way to cash my guns?" Rock Island Auction Company strives to sell your guns for the highest price possible. As the #1 firearms auction house since 2003, RIAC has a global clientele willing to pay top dollar for the right gun.
Is Now the Time to Cash my Guns?
The first step to cashing your guns with Rock Island Auction Company is reaching out for a free evaluation. Ballpark gun values can sometimes be determined over the phone, while other times a visual inspection is required.
RIAC's May 2022 Premier Auction brought in an astounding $28,225,850, with numerous guns achieving sales prices higher than their value estimates.
Recent sales data can also be found in our free gun catalogs, which provide a comprehensive guide to prices and trends in recent vintage firearms. When considering gun value by year at Rock Island Auction Company, we've analyzed sales data from our past auctions to provide gun cosigners a snapshot of the current market and a demonstration of how gun prices have been rising across multiple genres. To maintain consistency and accuracy, the graphs presented below have excluded multi-gun lots, rare prototypes, engraved and presentation pieces, and other extremely scarce and atypical examples. The buyer's premium is included in the sales price (15% during the periods analyzed), as this accurately reflects what a collector paid to own each firearm.
The average vintage Hi Power pistol value continued to trend upward in 2020 and 2021 at Rock Island Auction Company.
M1911 Prices and Values by Year
In recent years, classic military pistols like the Luger and the Mauser C96 have seen tremendous gains in value, and the M1911 is no exception. The M1911 pistol is a collecting genre onto itself, a gun that instantly evokes a century of American military history, and its steady rise in value should come as no surprise. As already stated, each dataset included in this article has intentionally omitted rare variations, and in the case of the M1911 pistol that means excluding manufacturers like Singer and North American arms.
The Average M1911 value by year at Rock Island Auction Company since 2015.
From 2015 to 2018, the average M1911 pistol price at Rock Island Auction Company hovered just over $4,000 before experiencing a dramatic upswing in 2019 and 2020. The momentum continued into 2021, a record year for RIAC and any consignors looking to cash their guns, and the demand for John Browning's iconic pistol shows no sign of slowing in 2022.
A U.S. Remington-Rand Model 1911A1 National Match pistol sold for $6,463 in May, 2022 at Rock Island Company.
M1 Garand Prices and Values by Year
It's hard to argue that any genre of gun collecting has experienced faster growth than vintage military arms. The BAR, the SVT40, and the Winchester Model 1897 combat shotgun are just a few examples of military guns that have seen their values sharply rise in recent years. Even the lesser revered Mosin Nagant has seen an impressive price increase of late. As the definitive WW2 American rifle, the M1 Garand often tops the gun collecting wish list. Going back through 11 years of M1 Garand prices at Rock Island Auction Company presents a clear look at the growth in value the WW2 infantry rifle has enjoyed.
The average M1 Garand value by year at Rock Island Auction Company since 2010.
Like the values observed in many popular gun genres, M1 Garand prices continue to trend upward at Rock Island Auction Company. The M1 Garand broke the $2,000 price barrier in 2012, then marched steadily higher in 2014 and 2015 before skyrocketing over the next six years. From 2010 to 2021, the M1 Garand more than doubled its value, and demand for this classic WW2 rifle shows no sign of slowing. Even though the rarest M1 Garands were excluded from the data, similar trends are observed throughout the genre.
World War II U.S. Springfield M1 Garand rifle sold for $3,819 with Rock Island Auction in May.
Colt M16A1 Prices and Values by Year
Who doesn't love a machine gun? Rock Island Auction Company's customers can't get enough of classic heavy hitters like the M60, the MP40, or the ultra-rare FG42. One of the most recognizable machine guns in history is the Colt M16, the successor to the Armalite AR-15.
The remarkable prices the M16 achieves at Rock Island Auction Company perhaps are influenced by how frequently the storied rifle has been depicted in film, television, and video games over the last few decades and their greater availability Rock Island Auction. Popular Guntubers like Garand Thumb and Hickok45 also contribute to the desire to own this rapid-fire Cold War classic.
The average Colt M16A1 value by year at Rock Island Auction Company since 2017.
The M16A1 rifle experienced a similar growth trend to the previous two examples, steadily climbing in value in 2018 at Rock Island Auction Company before gaining mightily in 2019, 2020, and 2021. Rising 64% in four years would be an impressive statistic for any gun, especially when the average price increase is a whopping $17,230.
A Colt M16A1 Rifle, Class III/NFA fully transferable machine gun so for $55,813 in RIAC's August Premier Auction, demonstrating the continued strength of U.S. military arms and the machine gun genre.
Whitney Wolverine Prices and Values by Year (nickel-plated with original box)
Another perennial hit with gun collectors, the Whitney Wolverine is an Atomic Age pistol with one of the most unique looking gun aesthetics of its era. Robert Hillberg's Wolverine is an example that demonstrates a gun doesn't need to be an antique, a military arm, or a rare Colt or Winchester to turn heads in the gun collecting community.
While all Whitney Wolverines manufactured between 1955 and 1962 are popular, the most desirable are the limited number to receive a nickel-plated finish. The graph below compares the average value by year that nickel-plated Whitney Wolverines achieved at Rock Island Auction Company. All examples included their original box and were in fine condition or higher.
The average nickel-plated Whitney Wolverine price (with original box) at Rock Island Auction Company since 2017.
The average price for a nickel-plated Whitney Wolverine at RIAC not only follows a similar trend to the other graphs presented so far, it provides an even more dramatic example of the booming firearms market. From 2017 to 2019 the Whitney Wolverine saw a 22% increase in value, then shot past the $3,000 barrier in 2020 before rocketing to an astronomical $5,031.50 in 2021. A worthy showing for gun inventor Robert Hillberg out-of-this-world design.
In August of 2022, a Whitney Arms Company Wolverine sold for $7,050.
Colt Python Prices and Values by Year
The Colt Python's popularity isn't surprising to most collectors. Pythons and other snake guns are handmade Colt revolvers that have been out of production for years and carry a reputation for quality, accuracy, and precision craftsmanship. Any gun that earns the title "The Rolls-Royce of Colt revolvers," is going to be a perennial hit with shooters and arms collectors, and the Colt Python prices and values realized at Rock Island Auction Company continue to bear this out.
The average Colt Python price at Rock Island Auction Company since 2014.
After a notable rise in 2015, the average Colt Python price at Rock Island Auction Company inched upward over the next three years before achieving a tremendous $2,939.39 in 2018. Though the Python saw a slight decline in 2019, this popular big iron revolver rallied back in 2020 and shattered all expectations in 2021 with an astounding $3,547.32. High-value Pythons such as the Colt Python Elite and early-year production models reflect a similar price trend, as does Colt's entire roster of deadly serpents, including the Diamondback, Cobra, Anaconda, King Cobra, Viper, and the extremely collectible Colt Boa.
With an estimated 200 manufactured, the California Combat Python is one of the rarest snake gun models. This example achieved a mindblowing $70,500 with Rock Island Auction Company in May, 2022.
How Can I Cash my Guns?
Once you consign with Rock Island Auction Company, your guns are shipped to our state-of-the-art facility, inventoried, photographed, marketed, and sold in one of our industry-leading firearms auctions. Getting cash for your guns has never been easier, and there's never been a better time to act.
An early production Colt large frame "Express Model" Lightning slide action rifle nearly tripled its high estimate with Rock Island Auction Company to bring in an outstanding $94,000.
Whether a single gun or a large gun collection, RIAC has an impressive record of success, an expanding list of gun collecting clientele, and a world-class production team that will ensure you receive the highest possible value for your gun.
An outstanding Rizzini sidelock double barrel ejector shotgun sold for $246,750 in Rock Island Auction Company's August 2022 Premier Firearms Auction.
Call Rock Island Auction Company at 1-800-238-8022.
Email Rock Island Auction Company at guns@rockislandauction.com.
Fill out a firearms consignment request by clicking here.
Contact us with your questions today. We can't wait to hear from you!
Restricting Gun Rights Won't Prevent Tragedy
Yukon Cornelius, Air Rifles, and Berettas – The Best Christmas Movie Guns


Limo in Vancouver has established and maintains security procedures to protect the confidentiality, security and integrity of your personal information.
The most important personal data that we take from our customers are your name, phone number, pick up address, ride dates and times, and credit card information. This data is required by Limo in Vancouver to perform the rides and charge our customers.
At Limo Vancouver, discretion is as much a part of our business as getting our customers from point A to point B on-time, safely, and comfortably. We value our customer's privacy and recognize the trust our customers place with us.


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If you love music and education, then Bach to Rock would be a perfect place for you to start your career.
Posted by Willy Franzen on September 7, 2011. Jobs updated daily.
Bethesda - Rock Band and Ensemble Coach
Advanced Piano Instructor - Private/Semi-Private Instruction
Fairfax, VA View
Rock Band and Ensemble Coach
Mc Lean, VA View
Music Teacher for Early Childhood Classes
Guitar Instructor - Private/Semi-Private & Group Lessons
Herndon, VA View
Vocal Instructor- Private/Semi-Private Lessons
Music Instructor - Rock Band and Ensemble Coach
Gaithersburg, MD View
Piano Music Instructor
Bristow, VA View
Bethesda - Assistant Director
Music School Assistant Manager
I started playing the drums in 5th grade. I started with a snare drum, but soon after I got a drum set that filled my entire bedroom. At about the same time I started taking private lessons, and I had a teacher who seem like the coolest guy in the world to my 11 year old self. After taking the summer off from lessons, I came back to my first lesson to find a new teacher sitting in the drum room. I was heartbroken. I never liked the new teacher, and my excitement for playing the drums never returned. I could have been a rockstar if only I had taken my lessons at Bach to Rock. They are "the Music School for students of all ages." They're based in Bethesda, MD, and they have a growing number of locations across Maryland and Virginia. They're also an Inc 5000 company that has seen an even 1,000% growth in their revenue over the past three years.
Bach to Work
Even though the recording industry seems to be struggling with how technology has fundamentally changed their business, music is as hot as ever. The Bach to Rock Method is all about engaging people who love music and keeping them excited about improving their talents. (I love that Bach to Rock's name says so much so simply.) Last year Bach to Rock generated $3.3 million in revenue, and I expect that number to keep increasing. They've adopted a franchising model, so there's a very clear path to future growth. If you want to be part of that growth, then you'll want to take a look at Bach to Rock's Jobs page. It includes listings for all of their locations, which include Bethesda, MD; Gaithersburg, MD; Herndon, VA; Leesburg, VA; McLean, VA; and Chantilly, VA. Most of the positions are for Music Specialists (Voice, Piano, Violin, Viola, Cello, Guitar, Bass, Drums, Early Childhood, Saxophone, Clarinet, Flute, Obo, and Bassoon), but they also have some Administrative Assistant and Audio Engineer/Composer positions. There's nothing at Corporate right now, but I'm sure there will be more positions as they continue to grow.
B2RMusic.com
Jobs at Bach to Rock
About Bach to Rock
Bach to Rock Faculty
Bach to Rock News
Did you play an instrument growing up?
We've identified Bach to Rock as having career opportunities in the following categories:


June 17-21, 2019 Full-Day Camp: EV3 ULTIMATE ROBOTICS – ages 8-13.
EV3 Ultimate Robotics main goal is to give campers the basic knowledge of the EV3 mechanics. Campers will learn how the pressure on a surface influences the movements of their robots, what friction is and how to use it to their advantage. This camp was created specifically for inquisitive children! They learn how to build robots with walking mechanism, convert rotational motion into translational motion, increase force with levers, gear and belt drives, work with motion and tilt sensors. And, of course, they will be able to breathe life into their robots using fascinating programs.


Iraq's first parliamentary elections since the defeat of ISIS were supposed to herald a return of stability to the country after 15 years of practically incessant war since the US invasion of 2003. But turn-out in the May 12 poll was at a mere 44%—a record low since 2003. And candidates were openly aligned with foreign powers playing for influence in Iraq. Incumbent Prime Minister Haidar al-Abadi's Nasr (Victory) coalition, backed by the US, Saudi Arabia and Turkey, appears to be squeaking past more populist tickets seen to be in the sway of Iran. These include the State of Law coalition of current vice president and former prime minister Nouri al-Maliki, who darkly warned that the results could be "rigged through electronic devices" as the returns started to come in. The ruling Dawa Party split into rival coalitions as Abadi and Maliki fell out, and a special law was passed in parliament allowing one party to run in competing lists. A third list, Fatah—headed by Hadi al-Amiri, leader of the Badr Brigades paramilitary militia—is considered solidly pro-Tehran. But the surprise so far is the strong showing of the Sairoon (Marchers) bloc, led by Shi'iite cleric Moqtada al-Sadr in an unlikely alliance with the Iraqi Communist Party. Independent of outside powers, Sadr played to resentment against the cronyism and corruption endemic to both factions of Dawa.


A PCEngine emulator for your GP2X.
One of several excellent emulators running on the GP2X. Brilliant work!
simply amazing! runs fast at default speed, i thought there was a bug, but it turns out it was the rom, sound is very important and sooo sweet!! thank you.
Great work, this is definitely one of the best emulators for gp2x.
rondo of blood is great!
Hi, anyone noticed the washed screen?! Franxis and god_hell resolved it in mame and it's a lot better! Please fix it! It's just a couple of line about lcd timing freq!
This emu is amazing it runs full speed and sound is great, the pc engine has some incredible classics which are cool.


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Diversity, Equity, and Inclusion /
Diversity Highlights /
Current page: Diversity Highlights
Taking Deliberate Steps to Combat Racism in the Classroom
November Diversity Highlights
Future Doctors Society
The VTCSOM Office of Diversity, Equity, and Inclusion, in collaboration with the Virginia Tech College Access Collaborative, hosted more than 40 underrepresented minority high school members of the Future Doctors Society from various high schools in Northern Virginia in November. The students had the opportunity to engage with various departments at VTC and learn about what makes us unique. Not only did they get to ask medical students all about their experience getting into medical school, but they also received a presentation from the admissions department to provide guidance on what they can begin doing while in high school to prepare for applying to medical school. Afternoon activities included a handwashing activity where the students learned the importance of proper handwashing using glow lotion and blacklights, a medical school tour, as well as a vital sign activity. Students were provided the gift of a stethoscope and sphygmomanometer kit and practiced taking blood pressures. The students were all interested in the healthcare field and remained engaged during the visit to VTCSOM.
VirTual Safe Zone Training
LGBTQ+ Resource Center
November 1 - December 11
VirTual Safe Zone 101 is an online 5-week intensive course with weekly readings, writings, and a live discussion lab. This course aims to:
introduce participants to contemporary introductory information regarding gender, sexual, and romantic minorities;
contextualize this new/refreshed knowledge with some of the complexity and nuanced characteristics of these elements;
provide the opportunity to engage in introspective or reflective thinking;
engage individuals in discussion with one another regarding their own understanding, feelings, and experiences with the course content;
and encourage active allyship during and after the course has ended.
Three Options Available:
Fridays at 9am with Jes Davis
Fridays at 10am with Ocqua Murrell
Fridays at 1 pm with Lamar Walker
Diversity and Inclusion Notes
The Virginia Tech Carilion School of Medicine has been awarded the 2021 Health Professions Heed Award from Insight into Diversity magazine - for the fourth consecutive year!
As part of our commitment to building an inclusive environment that values every member, the Diversity, Equity, and Inclusion team will be hosting a Riverside Chat series for applicants who are members of groups that are underrepresented in medicine. These chats serve as an informal venue for applicants to ask questions about the school, life as a medical student, and life as a resident of the Roanoke Valley. For more information or to assist with the monthly chats, contact Karyna Nevarez.
Karyna had this to say about the first Riverside Chat that took place last week: "We had an excellent response from prospective students. They were all very engaged and had great questions such as the diverse population in our city, engagement opportunities for them to connect with the diverse community, resources for our diverse students, and our city offerings in diverse culture. Looking forward to the November edition of the series."
Did you know that you can find events related to diversity, equity, and inclusion at VTCSOM all in one place? Events are continuously being added to the Diversity, Equity, and Inclusion calendar, which can be found on our website.
Holidays and celebrations in the month of November:
National Native American Heritage Month
National Family Caregivers Month
1: All Saints' Day
1-2: Dia de los Muertos
2: All Souls' Day
4: Diwali
5-6 (sundown to sundown): Birth of Báb, a Bahá'í holiday
6-7 (sundown to sundown): Birth of Bahá'u'lláh, the founder of the Bahá'í religion
11: Veterans Day
19: International Men's Day
20: Transgender Day of Remembrance
21: Feast of Christ the King
25: Thanksgiving
26: Native American Heritage Day
November 28-December 6: Hanukkah
November 28-January 6: Nativity Fast
November 28-December 24: Advent
October Diversity Highlights
InclusiveVTCSOM Task Force Update
Dean Learman presents the updates from each of the Task Force working groups during this town hall held on October 13.
Natalia Sutherland
Natalia Sutherland, a fourth-year student at VTCSOM, envisions a future in medicine close to her Hispanic roots. Her mother's side of the family is from Puerto Rico, and Sutherland speaks fluent Spanish. A pivotal moment of her young life occurred when she heard her mother, who was teaching English as a second language, explaining to Spanish-speaking students how to go to a doctor and what to say to get the care they needed. Read Natalia's story.
National Hispanic Heritage Month, celebrated September 15 to October 15, provides an opportunity to recognize contributions to Latinx communities locally, regionally, and nationally. This year 6 Virginians were honored for their work at an event held at the Capitol with Senators Kaine and Warner, including our own faculty member, Elda Stanco Downey, PhD. Dr. Downey was recognized for the impact of her work including her roles teaching in the classroom and collaborating on DEI initiatives at VTCSOM.
Other holidays and celebrations in the month of October:
National Disability Employment Awareness Month
Global Diversity Awareness Month
1: Native American Women's Equal Pay Day
4: St. Francis Day, feast day for St. Francis of Assisi, the patron saint of animals and the environment
6-14: Navaratri, Hindu festival celebrating the triumph of good over evil
10: World Mental Health Day
11: National Coming Out Day (US)
11: Thanksgiving (Canada)
11: National Indigenous Peoples Day
18-19: (sundown to sundown): Eid Milad un-Nabi/Mawlid Al-Nabi (Sunni Islamic holiday commemorating the birthday of the prophet Muhammad)
20: Sikh Holy Day (celebration of Sri Guru Granth Sahib)
20: International Pronouns Day
23: Milad un-Nabi (Shia Islamic holiday commemorating the birthday of the prophet Muhammad)
29: Latinx Women's Equal Pay Day
31: All Hallows' Eve (Halloween)
31: Reformation Day (Protestant Christian religious holiday)
October 31-November 1 (sundown to sundown): Samhain, a Gaelic festival marking the end of the harvest season and the beginning of winter or the "darker half" of the year.
September Diversity Highlights
The History of Race and the Ethical Future of Public Health presentation by Dr. Sylvester Johnson. Details and the recording of the presentation are available.
Virginia Tech Carilion School of Medicine is proud to be a sponsor of "Race, Health, and Future Humans: Lessons from the Legacy of Henrietta Lacks" to be held at Roanoke College on Thursday, September 23.
Critical Race Theory (CRT) Academic Symposium: What is or is not CRT?
Commonwealth Ballroom B
Squires at Virginia Tech
The 2021 VA Pride Scholarship is now accepting applications. Light up your future with this amazing opportunity. VTCSOM medical students are eligible to apply for this scholarship. Applications will be evaluated on how the applicant says they will apply their education to advancing LGBTQ equality. Deadline to apply is September 10, 2021.
Virginia Tech hosts Inclusive VT Week Speaker Series:
September 7: Dr. Lisa Nunn will present Fostering College Belonging: Practical strategies for fostering student success by strengthening students' sense of belonging, with a focus on first-generation college students.
September 9: Presentation by Dr. Fred Bonner II, author of Square Pegs and Round Holes: Alternative Approaches to Diverse College Student Development Theory.
September 10: Dr. Margaret Price will present Creating an Inclusive and Accessible Campus.
Holidays and celebrations in the month of September:
Hispanic Heritage Month is observed from September 15 to October 15
4-11: Paryushana Parva
6: Labor Day
6-8: (sundown to sundown): Rosh Hashanah
10: Ganesh Chaturthi
11: Ethiopian New Year
15-16: (sundown to sundown): Yom Kippur
18: International Equal Pay Day
20-27: Sukkot
22: Ostara Mabon
24: Native American Day
27: Elevation of the Life-Giving Cross (Holy Cross)
27: Meskel
27-29: (sundown to sundown): Shemini Atzeret
28-29: (sundown to sundown): Simchat Torah
29: Michaelmas
August Diversity Highlights
Virginia Tech Carilion School of Medicine is proud to be a sponsor of the Second Annual Black Father Festival at Westside Elementary in Roanoke, to be held August 22, 2021. Dean Learman will also be speaking at that event.
Kory Cablay, Class of 2022, and Sarah Yosief, Class of 2023, are both scholarship recipients at the Virginia Tech Carilion School of Medicine. They sat down to discuss why they want to become physicians and how the scholarships have helped them along in their journeys. Cablay received the VTC Diversity Excellence in Medicine Scholarship Fund, which was established by Drs. Frank and Jennifer Clark to support underrepresented students. Yosief received the Caroline Osborne Memorial Scholarship, which was established to honor the memory of Caroline Osborne, who was a member of the school's Charter Class.
Registration is now open for Virginia Tech's annual Diversity Summit to be held August 11. The event will feature short, asynchronous sessions available all day. There will be live components on a by-invitation basis including the keynote speaker, Claude Steele, whose lecture will be livestreamed from 9-10:15 a.m.
Holidays and celebrations in the month of August:
6: Feast of the Transfiguration
10: Hijri (Islamic New Year)
13: Black Women's Equal Pay Day
17: Marcus Garvey Day
18-19: Ashura (sundown to sundown)
22: Obon
22: Hungry Ghost Festival
26: Women's Equality Day
29-30: Krishna Janmashtami
July Diversity Highlights
VTCSOM Mentoring Communities - call for faculty mentors:
The VTCSOM offices of Student Affairs and Diversity, Equity, & Inclusion are leading the school's transition from our current Physician Thought Leader Communities to Mentoring Communities. Mentoring Communities are faculty-led student communities that provide an administrative structure through which students can experience individualized advising and mentoring that fosters personal and professional growth, some within a specific identity group. If you'd like to be considered for mentorship, please fill out this quick survey.
Yes I want to be a community mentor
VirTual Safe Zone 101 Training
Register today for Summer 2: June 28th - July 30th
Meets Fridays at 11am with Jes Davis
Meets Fridays at 1pm with Alison Sibol
Meets Fridays at 2pm with Dr. Jess Wescott
Meets Thursdays at 2pm with Robby Specht
VirTual Safe Zone 101 is an online 5-week intensive course with weekly readings, writings, and a live discussion lab. The curriculum is meant to assist with the development of content knowledge.
The course curriculum delivers basic information to begin your development of content knowledge.
The readings are meant to help deepen your scope of the topic.
The discussion board reflective writings provide the opportunity to explore your thoughts, feelings, and questions.
The live discussions engage you in conversation with one another and allow for questions to be proffered to the group.
VirTual Trans Safe Zone 101 Training
Meets Thursdays at 3pm with Gerlyn Murrell
VirTual Trans Safe Zone 101 is an online five-week course addressing transgender identities and issues. This course aims to
introduce participants to contemporary introductory information regarding gender minorities;
and encourage active allyship during and after the course has ended
Please note: VirTual Safe Zone is a prerequisite and must be completed before this course can be taken.
June Diversity Highlights
Microaggressions and Microinterventions
On June 17th at 10 a.m., Dr. Derald Wing Sue will be addressing issues related to microaggressions and micro-interventions that respond to the U.S. socio-cultural and political climate. His knowledge and expertise about microaggression theory have been widely acknowledged and integrated into the U.S. mainstream public discourse as well as within the academy. During this event, Dr. Sue will share how his experiences, research, and scholarship can be disseminated and utilized at a place like Virginia Tech. To learn more and register please follow this link
Arizona State University is hosting a conference on Cultivating Black and Native Futures in Education from June 17-19.
June is:
LGBTQ+ Pride Month
Immigrant Heritage Month
Holidays and celebrations in the month of June:
3: Corpus Christi
11: Feast of the Most Sacred Heart
14: Flag Day
19: Juneteenth (observed June 18)
20: Father's Day
21: Litha (Midsummer)
27: LGBTQ+ Pride Day
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Global Accessibility Awareness Day: our commitment to accessibility , redirect
In honor of Global Accessibility Awareness Day, we take this opportunity to share what the Virginia Tech Carilion School of Medicine has done to advance accessibility in its digital environment, and share tips on how you can improve accessibility in your own sphere of influence.
May Diversity Highlights
View Event Video
May Highlights
On Tuesday, May 11, Dr. Nina Ha, Director of Virginia Tech's Asian Cultural Engagement Center will facilitate the May Diversity Lunch and Learn to discuss a presentation by Dr. Simona C. Kwon: Asian Americans and Health Equity: Dismantling Stereotypes.
May is:
Older Americans Month
Holidays and celebrations in the month of May:
2: Orthodox Easter
5: Cinco de Mayo
6: National Day of Prayer
9: Laylat al-Qadri
12-13: Eid al-Fitr (sundown to sundown)
16-18: Shavuot (sundown to sundown)
17: International Day Against Homophobia, Transphobia, and Biphobia
21: World Day for Cultural Diversity for Dialogue and Development
26: Vesak/Visakha Puja
31: Memorial Day
Register today for Summer 1: May 17th - June 18th
Meets Fridays at 2pm with Dr. Jess Westcott
Meets Fridays at 3pm with Jes Davis
Meets Thursdays at 1pm with Alison Sibol
April Diversity Highlights
1. 9th Annual Faculty Women of Color in the Academy National Conference April 9
2. #VTUnfinished Conversation on April 5 at 11:30 a.m. President Tim Sands will be joined by Menah Pratt-Clarke, vice president for Strategic Affairs and Diversity, Guru Ghosh, vice president for Outreach and International Affairs, Jessica Nguyen, president of the Asian American Student Union, Silas Cassinelli, assistant professor in the Department of English, and Nina Ha, director of the Asian Cultural Engagement Center. The event will be livestreamed on this page and on the InclusiveVT YouTube channel.
On April 21 at 9am, the basic science education department is hosting Neurodiversity panel discussion: Different perspectives of autism with five panelists, and moderated by department chair Renee LeClair.
Stanford's Teaching LGBTQ+ Health course: a faculty development course for health professions educators.
This curriculum is designed for faculty members and health professions educators at Stanford Medicine and beyond. The course goals are to improve your knowledge, teaching skills, and attitudes pertaining to the provision of health care to LGBTQ+ patients. View the course trailer.
#StopAAPIHate
As educators, it is our responsibility to resist false narratives that fuel xenophobic crimes and to decolonize thinking that props up model minority and orientalist stereotypes. As educators, it is our responsibility--collectively and individually--to reflect, read, learn, and act toward justice, and to understand the intersections of identities that shape our lived experiences.
Learn more about the #StopAAPIHate initiative.
#StopAAPIHate: Resisting Xenophobia and Showing Support for Asian Pacific Islander Desi Americans (APIDA). Click image to download resource guide
March is Women's History Month
In honor of Women's History Month, we are highlighting the documentary PICTURE A SCIENTIST.
PICTURE A SCIENTIST is a documentary film chronicling the groundswell of researchers who are writing a new chapter for women scientists. A biologist, a chemist and a geologist lead viewers on a journey deep into their own experiences in the sciences, overcoming brutal harassment, institutional discrimination, and years of subtle slights to revolutionize the culture of science. From cramped laboratories to spectacular field sites, we also encounter scientific luminaries who provide new perspectives on how to make science itself more diverse, equitable, and open to all.
VTCSOM celebrates Black History Month 2021 , article
Events hosted by Virginia Tech Carilion School of Medicine and Fralin Biomedical Research Institute in honor of black history month include
February 4: #VTCUnfinished: Black Maternal Health
February 15: FBRI Virtual Seminar: Forward - Why We Cannot Not Go Back to Where We Were
February 23-25: Black Men in White Coats - documentary and discussion
Progress Notes | February 2021
The next #VTCUnfinished event will be held virtually on Thursday, February 4 from 6 to 7 p.m. Titled "Black Maternal Health," this session seeks to provide space to discuss how implicit racial and gender biases can change health care outcomes, what disparities currently exist, and how to begin dismantling health injustice. By disseminating best practices to address critical issues in Black maternal health from different sectors including research, care, policy, and culture; we can frame health equity and reproductive justice for Black Women.
The event is hosted by the VTC Chapter of the Student National Medical Association, the VTC Refugee in Medicine Association, the VTC Group on Women in Medicine and Science, and the VTC Obstetrics & Gynecology Interest Group. Registration required.
Virginia Tech Carilion School of Medicine has obtained a number of licenses for interested parties to view the documentary Black Men in White Coats on their own devices from February 23 - 25. It will also be shown in the Auditorium (M203) on February 25 at 3 p.m. A discussion will follow both live and on Zoom. Registration for online or in-person participation is required.
Progress Notes | January 2021
Registration is open for Virginia Tech's Advancing Diversity Virtual Gathering on Jan. 12, 2021.
Online diversity pathways and inclusive pedagogy spring courses.
There are new courses on the TLOS professional development network for diversity and inclusion. In addition, new SafeZone courses are available for the spring.
The Breakthrough Inclusive Action Tool Kit is available for anyone ready to become an agent of change in the academy! Although it is written for students and faculty in STEM fields, the content is adaptable to any academic unit. This excellent resource was produced in collaboration with Science Friday and the Howard Hughes Medical Institute Tangled Bank Studios.
Progress Notes | December 2020
Registration is open for Virginia Tech's Advancing Diversity Virtual Gathering on January 12, 2021.
Do you have aging relatives? Will they need your support to age well?
Our recent Lunch and Learn focused on relevant information about what caring for an aging relative entails and why you and your loved ones should prepare. This session was full of great information and resources.
Progress Notes | November 2020
Last month's Lunch and Learn featured a discussion about inclusive language and terminology and was led by Charlotte Baker with the Department of Population Health Sciences at Virginia Tech. The graphic from her presentation is an excellent visual of the difference between the terms "equality" and "equity."
View the slides
Diversity, Equity, and Inclusion at VTCSOM


Bathtub party. Hmmm. That sounds interesting.
Could be, but it is 4* here this morning and not into moving around much.
Shhhhhhhhhh, you'll wake up the Motorsports Racing World.
34 * and clouds coming in, with mid 40's for a hi.
34* cloudy and on the fringe of the snow line.
I don't know what's so good about it.
The main roads are in good shape according to my son, who has already been out on them.


text:
module Projects
  class GitlabProjectsImportService
    include Gitlab::Utils::StrongMemoize
    include Gitlab::TemplateHelper

    attr_reader :current_user, :params

    def initialize(user, import_params, override_params = nil)
      @current_user, @params, @override_params = user, import_params.dup, override_params
    end

    def execute
      prepare_template_environment(template_file)

      prepare_import_params

      ::Projects::CreateService.new(current_user, params).execute
    end

    private

    def overwrite_project?
      overwrite? && project_with_same_full_path?
    end

    def project_with_same_full_path?
      Project.find_by_full_path(project_path).present?
    end

    # rubocop: disable CodeReuse/ActiveRecord
    def current_namespace
      strong_memoize(:current_namespace) do
        Namespace.find_by(id: params[:namespace_id]) || current_user.namespace
      end
    end
    # rubocop: enable CodeReuse/ActiveRecord

    def project_path
      "#{current_namespace.full_path}/#{params[:path]}"
    end

    def overwrite?
      strong_memoize(:overwrite) do
        params.delete(:overwrite)
      end
    end

    def template_file
      strong_memoize(:template_file) do
        params.delete(:file)
      end
    end

    def prepare_import_params
      data = {}
      data[:override_params] = @override_params if @override_params

      if overwrite_project?
        data[:original_path] = params[:path]
        params[:path] += "-#{tmp_filename}"
      end

      if template_file
        params[:import_type] = 'gitlab_project'
      end

      params[:import_data] = { data: data } if data.present?
    end
  end
end

Projects::GitlabProjectsImportService.prepend_if_ee('EE::Projects::GitlabProjectsImportService')

redpajama_set_name: RedPajamaGithub


text:
The Never and the Ever! "The School for Good and Evil's" Sofia Wylie and Sophia Anne Caruso Talk Netflix Fantasy Adventure
Sofia Wylie is Agatha and Sophia Anne Caruso is Sophie in the new Netflix fantasy-adventure "The School for Good and Evil." Both must choose sides as they are swept away to a magical school that teaches students how to be heroes and villains.
I spoke with the actors to talk about their characters, and the film's message.
Inside the Magical World of Netflix's "The School for Good and Evil"
Does the author Soman Chainani like director Paul Feig's adaptation of his novel "The School for Good and Evil?" And why did Feig jumped from comedies ("Bridesmaids," "The Heat") to direct the fantasy-adventure for Netflix? Take a look at our interview from this morning's NBC Palm Springs.
Timothy Granaderos Talks About Horror Films, Being Filipino, and "Devil's Workshop"
Timothy Granaderos takes you behind the scenes of his new horror flick "Devil's Workshop."
Hamish Linklater, Samantha Sloyan Reveal "Midnight Mass" Secrets
"Midnight Mass" is currently at the top of the Netflix charts. The seven-episode series from Mike Flanagan ("Doctor Sleep," "The Haunting of Hill House") has Hamish Linklater as the mysterious Father Paul and Samantha Sloyan as the self-proclaimed servant of God. "Midnight Mass" is now out and you should binge-watch the series.
Religion and the Supernatural: Kate Siegel and Zach Gilford Talk to Manny the Movie Guy About "Midnight Mass"
Religion and the supernatural. Kate Siegel (Erin) and Zach Gilford (Riley) take us behind-the-scenes of Netflix's "Midnight Mass."
Manny the Movie Guy Reviews "Dear Evan Hansen" and Netflix's "Midnight Mass"
Only at the movies, the big screen version of the Tony-winning musical "Dear Evan Hansen" sings its way to the theaters. And over on Netflix, the new 7-episode series "Midnight Mass" from Mike Flanagan ("The Haunting of Hill House," "The Haunting of Bly Manor," "Doctor Sleep"). Which one is my pick of the week? Take […]
Manny The Movie Guy Reviews "The Eyes of Tammy Faye," "Chicago Party Aunt," "Nightbooks," "Everybody's Talking About Jamie"
From a movie about Tammy Faye Bakker to a musical about a boy who dreams of being a drag queen, it's a busy weekend in Hollywood. Take a look at what I think about "The Eyes of Tammy Faye," "Chicago Party Aunt," "Nightbooks," and "Everybody's Talking About Jamie." To see my complete interviews, click here.
Secrets of "The Djinn" – How Limited Resources Sparked Creativity
Set in 1989, "The Djinn" tells the tale of a mute boy who accidentally opens the portals of evil. Writers/directors David Charbonier and Justin Powell created a scary yet heartfelt movie about growing up with a "Home Alone" and "The Little Mermaid" twists. You know why they created their main character mute? So, they didn't […]


text:
Residents and Fellows 33
Teamwork Training 16
Narrative/Storytelling 2
Never Events 2
Public Reporting 1
Duty Hour Limitation 15
Fatigue and Sleep Deprivation 11
Administration Errors 2
Ordering/Prescribing Errors 3
Outpatient Surgery 1
Cardiothoracic Surgery 1
Department of Defense (DOD) 1
The collapse of sensemaking in organizations: the Mann Gulch disaster. Get Citation
Weick KE. Adm Sci Q. 1993;38:628-652.
This article is a review and analysis of the Mann Gulch fire disaster, an event made famous in Norman Maclean's award–winning book, Young Men and Fire (1992). Using the story of a firefighter who improvised a response to a fire by setting a back-fire while the rest of his crew panicked and ultimately perished, Weick examines the disintegration of role structure and sensemaking within an organization. He discusses sources of resilience that make groups less vulnerable, including improvisation, virtual role systems, the attitude of wisdom, and norms of respectful interaction. The purpose is to understand why organizations unravel and how they become more resilient. The organizational literature is reviewed to demonstrate a need for reexamination of successful group structures. Weick's work influenced many others who have written about improving safety, particularly in teams that work in fast-moving and ambiguous clinical settings.
Error reduction and performance improvement in the emergency department through formal teamwork training: evaluation results of the MedTeams project. Get Citation
Morey JC, Simon R, Jay GD, et al. Health Serv Res. 2002;37:1553-1581.
Using crew resource management (CRM), behavioral principles developed in aviation, this study reports on applying similar teamwork training in hospital emergency departments. After developing and implementing a modified training curriculum, investigators measured its effectiveness by addressing three outcomes: team behaviors, attitudes and opinions, and emergency department performance. The prospective study used physician-nurse teams for training and observation of a broadly defined range of clinical errors. Authors concluded that teamwork training based on CRM led to successful improvements in specific teamwork behaviors, reduced clinical errors, and enhanced staff attitudes toward teamwork.
Teaching smart people to learn. Get Citation
Argyris C. Harv Bus Rev. May/June 1991;99-109.
Argyris, a Harvard Business School professor, theorizes that companies and organizations must learn in order to continually improve and succeed, but that most professionals do not know how to learn. Using examples from the business consulting world, Argyris describes the tendency for highly successful and highly motivated professionals to employ "defensive reasoning" in problem solving. As individuals, they effectively analyze and problem solve within the organization but become defensive when asked to reflect critically on their own performance or behavior. He states that people can be taught to recognize the faulty reasoning they use when they design and implement their actions and to develop a deeper understanding of their role within the organization.
Patient safety: what about the patient? Get Citation
Vincent CA, Coulter A. Qual Saf Health Care. 2002;11:76-80.
In this perspective, Vincent and Coulter highlight the need for increased patient involvement in the patient safety movement. The authors emphasize that neither the patient's role in preventing errors nor the impact of these errors on patients and their families has been adequately addressed. The authors outline the patient's role in increasing diagnostic accuracy, determining appropriate treatment, choosing experienced providers, ensuring effective treatment and disease management, and monitoring adverse events. In addition, the authors explain that psychological injury from medical errors must be acknowledged and dealt with appropriately, including honest disclosure, apology, continued support, and plans for preventing future events.
Forgive and Remember: Managing Medical Failure. 2nd ed.
Bosk CL. Chicago, IL: University of Chicago Press; 2003. ISBN: 0226066789.
In this seminal study, Bosk, a medical sociologist at the University of Pennsylvania, spent a year observing the surgical residents and faculty at an unnamed hospital, in the process exploring the balance between autonomy and oversight in medical training, how physicians deal with their errors, and the nature of accountability in the medical profession. This edition, published more than two decades after Forgive and Remember was first published, includes a new prologue, epilogue, and list of appendices. The book is informative for both lay readers and clinicians.
A Tale of Two Stories: Contrasting Views of Patient Safety.
Cook RI, Woods DD, Miller C. Chicago, IL: National Patient Safety Foundation; 1998.
A report from a workshop, this document is a well-written look at the differences between "first stories" and "second stories" describing major errors. First stories are the easy one-person or one-cause accounts and reactions to critical incidents. "So-and-so forgot to check the patient's allergy history." Or "How could they have ignored the alarm and so many other red flags?" Even now, with some penetration of the concepts of systems thinking, it is still easy to fall back on the familiar and easy explanation of human error, missing key opportunities to fix underlying problems with processes of care or the way care is organized. Identifying such problems, however, requires the far richer "second stories" about such critical incidents, and these stories do not emerge without hard work. The authors have done this hard work for many publicized medical errors, drawing on follow-up newspaper articles and other investigative documents, often in far more obscure places than headlining first stories. Even readers familiar with root cause analysis will likely find value in many of the case studies. And, for those not familiar with such accident investigation techniques, the report provides a very readable introduction to their importance and a resource for further references.
Medical Problem Solving: An Analysis of Clinical Reasoning.
Elstein AS. Boston, MA: Harvard University Press; 1978.
Clinical reasoning lies at the heart of formulating diagnoses and selecting treatments. The results of these medical decisions determine a substantial portion of the dollars spent on health care. Considering the fundamental importance of clinical reasoning, the topic has received surprisingly little systematic study. Even with the widespread interest in medical error and patient safety in recent years, diagnostic errors and other errors in clinical reasoning have received little attention. This classic collection of empiric studies on clinical reasoning in action thus remains highly relevant more than 25 years after its original publication. One finding of particular relevance for those interested in patient safety and quality improvement is that competence may be problem specific; thus, there is no generic approach to clinical problem solving that, when followed, ensures excellent, or even competent, performance in a variety of domains within a field. The authors also provide an excellent overview of theoretic models relevant to the study of clinical reasoning.
Out of the Crisis.
Deming WE. Cambridge, MA: The MIT Press; 2000.
Deming believes that American companies need to transform their method of management to engage and compete successfully. In Out of the Crisis, originally published in 1986, Deming presents his classic theory based on his 14 Points for Management. Deming provides a distinct emphasis on the role of leadership to generate the change required for American business to remain vital. His thoughts on how to change management thinking in order to achieve success have been applied to the health care quality movement.
Systems errors versus physicians' errors: finding the balance in medical education. Get Citation
Casarett D, Helms C. Acad Med. 1999;74:19-22.
The movement to systems thinking as a mechanism to reduce errors poses unique challenges in academic medical centers. This article illustrates the need to balance the systems approach to error prevention with the valuable educational opportunities for training physicians when personal errors occur. Discussion suggests that if physicians rely on searching only for systems solutions, the important process of modifying future behaviors will be lost. The authors offer a number of solutions, which include active efforts by training programs to foster optimal learning environments and avoid reinforcement of blame, fear, and inadequacy. Role modeling, an essential part of every teaching hospital, must not only support disclosure of error but also demonstrate the importance of personal responsibility. This article is a useful reminder to educators in their efforts to train physicians for the future.
Changes in the diagnostic process during 40 years of clinicopathologic conferences. Get Citation
Feinstein AR, Niebyl JR. Arch Intern Med. 1971;128:774-780.
This study reports and analyzes findings of traditional clinicopathologic conferences (CPC) from Massachusetts General Hospital. By comparing the distribution of topics and the accuracy in making correct diagnoses over several decades, the authors explore one of the oldest forms of reasoning. The cases reviewed were classified both by clinical topic and error type to better understand the trends and patterns seen in diagnostic failures. The authors discuss the teaching role employed by CPC and the potential for computers to play an integral role in the diagnostic reasoning process.
Internal Bleeding: The Truth Behind America's Terrifying Epidemic of Medical Mistakes. Updated edition.
Wachter R, Shojania K. New York, NY: Rugged Land; 2005. ISBN: 1590710738.
Wachter and Shojania adapted many of the cases they previously published in the academic literature, some cases previously described in the lay literature (eg, the Duke transplant mix-up and the death of Betsy Lehman at Dana-Farber Cancer Institute), and other cases never previously reported to provide a dramatic account of medical errors and the field of patient safety. Dr. Lucian Leape wrote that Internal Bleeding "shows how cognitive psychology and human factors engineering provide the way out by shifting attention from blaming individuals to fixing faulty systems." The book, now in its fourth printing, continues to be a popular choice for anyone with an interest in patient safety.
Educational levels of hospital nurses and surgical patient mortality. Get Citation
Aiken LH, Clarke SP, Cheung RB, Sloane DM, Silber JH. JAMA. 2003;290:1617-1623.
This study examines the relationship between nursing educational levels and patient outcomes using cross-sectional analyses of outcomes data. Investigators studied more than 230,000 general, orthopedic, and vascular surgery patients discharged from 168 Pennsylvania hospitals. Results showed lower mortality rates in hospitals with higher levels of nursing education after adjustment for patient and hospital characteristics, as well as nursing factors. The authors suggest greater emphasis on nursing education, nursing workforce planning, and adequate financing to support these efforts nationally with the ultimate goal of improving patient care.
Advances in Patient Safety: From Research to Implementation.
Rockville, MD: Agency for Healthcare Research and Quality; February 2005. AHRQ Publication Nos. 050021 (1-4).
With 4 volumes and 140 articles (all of which are freely available through the link below), this expansive collection of literature illustrates the progress made since the 1999 Institute of Medicine's report, To Err is Human: Building a Safer Health System. The efforts represent a successful collaboration between the Agency for Healthcare Research and Quality and the Department of Defense-Health Affairs in meeting the challenge of improving patient safety knowledge, research, and implementation.
Five years after 'To Err is Human': what have we learned? Get Citation
Leape LL, Berwick DM. JAMA. 2005;293:2384-2390.
Two of the leaders in the patient safety movement, Lucian Leape and Donald Berwick, share their perspectives on the progress made since the Institute of Medicine's (IOM) release of To Err is Human. They summarize the shifts in thinking that have occurred, from blaming individual physicians towards targeting systems as a method to improve both quality and safety. Discussion includes the evolution of error prevention strategies, the role of interested stakeholders in the safety movement, and the impact of implementing best practices. Barriers to ongoing progress are also shared, including the increasing complexity of health care, a tradition of autonomy in care, and the current financial incentive systems. The authors provide a vision for the next five years with expectations for rapid change in adoption of electronic medical records, teamwork training, and full disclosure to patients. While they applaud several efforts and initiatives, such as the growth of AHRQ-funded research, the authors call for a rededication of providers and policymakers to the cause of patient safety, promoted by increased funding, better alignment of incentives, and the setting of ambitious but achievable safety targets.
Fixing healthcare from the inside, today. Get Citation
Spear SJ. Harv Bus Rev. September 2005;83:78-91.
This commentary provides a broad overview of the issues facing health care systems in their efforts to promote quality and safety. The author discusses pervasive cultural barriers and process limitations that contribute to errors, while providing a series of anecdotes to demonstrate how easy and frequent these events can occur. Approaches for improvement that draw from the experiences of non-health care organizations, such as Toyota, are included. The strength of the commentary lies in the compelling stories shared and the perspectives offered to foster change.
An objective methodology for task analysis and workload assessment in anesthesia providers. Get Citation
Weinger MB, Herndon OW, Zornow MH, Paulus MP, Gaba DM, Dallen LT. Anesthesiology. 1994;80:77-92.
This study developed techniques to allow objective description of task characteristics, workload, and vigilance in operating room settings. Using three measurement strategies, the investigators studied two cohorts of anesthesia providers, including a more experienced group with less attending supervision and a less experienced group with more attending supervision. The authors report on the different patterns observed in the two groups and discuss how these techniques provide useful information for future investigation and educational training requirements. Their study represents one of the first to apply human factors research techniques to a clinical anesthesia environment.
Simulation study of rested versus sleep-deprived anesthesiologists. Get Citation
Howard SK, Gaba DM, Smith BE, et al. Anesthesiology. 2003;98:1345-1355.
This study of anesthesiology residents demonstrated that fatigue negatively impairs psychomotor functioning and mood but not measures of clinical performance. Investigators examined, scored, and analyzed the observed behaviors of 12 residents in differing states of prior sleep. The findings support the notion that fatigue can lead to errors as a result of impaired cognitive abilities even if the more difficult to measure clinical performance outcomes were less affected. These findings are the first from a comprehensive simulation study addressing the effects of provider fatigue.
Simulation based teamwork training for emergency department staff: does it improve clinical team performance when added to an existing didactic teamwork curriculum? Get Citation
Shapiro MJ, Morey JC, Small SD, et al. Qual Saf Health Care. 2004;13:417-421.
This study determined that, while high-fidelity medical simulation offers an attractive mechanism for supplementing traditional didactic teamwork training, clear benefit from the added approach is not clear. Investigators combined didactic programs previously described with an intervention focused on putting participants through a series of simulated clinical scenarios. Behaviors of the two groups were rated by outside expert observers using a validated scoring scale. The actual participants did rate the simulation exercises as useful, suggesting a potential role for simulation as an educational method.
Incidence, patterns, and prevention of wrong-site surgery. Get Citation
Kwaan MR, Studdert DM, Zinner MJ, Gawande AA. Arch Surg. 2006;141:353-358.
This AHRQ-supported study analyzed information from nearly 3 million operations between 1985 and 2004, discovering a rate of 1 in 112,994 cases of wrong-site surgery. Investigators further evaluated cases with available medical records, all of which were among the malpractice claims. In doing so, they noted that the Joint Commission's Universal Protocol might have prevented only 62% of the cases reviewed. At the rates reported, the authors suggest that the average large hospital may be involved in such an event every 5 to 10 years, a rate 10 times less frequent than retained foreign bodies. They also point out that while wrong-site surgery is a devastating and unacceptable outcome, current efforts to implement protocols may not prevent every event and may, in turn, create inefficiency in related processes. The authors offer a series of recommendations for a model site-verification protocol. The American College of Surgeons offers a fact sheet on correct-site surgery geared toward patient education.
Learning from mistakes: factors that influence how students and residents learn from medical errors. Get Citation
Fischer MA, Mazor KM, Baril J, Alper E, DeMarco D, Pugnaire M. J Gen Intern Med. 2006;21:419-423.
Investigators conducted and analyzed nearly 60 structured interviews with medical trainees and categorized the factors that influenced their learning from errors. These factors were grouped as topic areas, which included awareness of error, factors influencing learner response (eg, personality, hidden curriculum), types of responses reported (eg, emotional, cognitive), and formal teaching. The authors discuss recommendations and specific educational methods that may promote improved learning from errors for trainees. A past study discussed one of these methods, Morbidity and Mortality Conferences, as a place to discuss medical errors with an educational focus.


The OHSU Comprehensive Epilepsy Center offers a two-year training in adult epilepsy, including a first year in the epilepsy fellowship accredited by the Accreditation Council for Graduate Medical Education and a second year of advanced epilepsy training.
Fellows have the chance to work with eight adult epileptology faculty at OHSU and partners at the Epilepsy Center of Excellence at the Portland VA Medical Center. Successful completion of the ACGME-accredited component prepares the fellow to become certified in epilepsy by the American Board of Psychiatry and Neurology. Fellowship includes substantial training in pediatric EEG, or electroencephalogram, reading and epilepsy management, and elective time is provided. It also includes clinical or basic science research components.
The program faculty includes faculty from neurosurgery, neuroradiology, neuropsychology, nurse practitioners and nursing.
We have filled our 2019 position. We are accepting applications on an ongoing basis for one position that will begin July 1, 2020.


text:
Somebody Say...
By Mark Jordan
FEBRUARY 9, 1998: More than anything, Joseph Shabalala remembers the voices. They are the voices from his old dreams, the voices of children singing a new style of music, one that blends the traditional South African music of his youth with the sweet melodies of American gospel, the music of his adopted religion, Christianity.
They are the voices that have manifested in Ladysmith Black Mambazo, the group Shabalala formed 34 years ago to give his dream shape. They are the voices that, though he hasn't heard them in more than three decades, still touch almost every aspect of his life.
Though its roots reach deep into African cultural history, the specific style of a cappella music Shabalala and Ladysmith perform, called isicathamiya or "township jive," dates back to the 19th century, when South African blacks, even then subjugated to the white minority, were forced to work in the country's diamond mines. Living far from home in work camps, the miners had only one day off a week, Sunday. So, Saturday nights became the night to socialize and let loose. The spirited vocal music that grew out of the Saturday-night parties was accompanied by choreographed dancing that was sometimes so aggressive the wooden floors of the workers' huts would crack under the pounding.
"When the people sang and danced to the music, the neighbors complained to the guards at the camp," Shabalala says. "So the dancers developed this style of dancing lightly on their toes called cothoza mfana. It means 'tiptoeing.'"
The new, powerful mix of singing and dancing soon spread back to the townships, and groups specializing in isicathamiya sprung up everywhere. These groups also developed a tradition of "facing off" in competitions which inspired community pride in one's local isicathamiya group.
As a teenager in the '50s, Shabalala became entranced by isicathamiya and joined one such group called the Blacks. Shabalala quickly realized he had a gift for music – "Initially I thought that I was brilliant," he told Ebony in 1996, "but now I know it was God." – and soon became the Blacks' leader and chief composer. The group was very popular and won many competitions, but, Shabalala says now, he was never content with the music they were making.
Then in 1964, Shabalala began experiencing the series of dreams that would inspire his new sound. Shabalala tried to teach the sound in his dreams to the Blacks, but "it was very hard for them to learn, so I formed a new group."
Drawing on friends and family members, Shabalala formed Ladysmith Black Mambazo in '64. (Today, the group includes Russel Mthembu, Inos Phungula, Jabulani Dubazana, Shabalala's cousins Abednego and Albert Mazibuko, and his brothers Jockey, Sibongiseni, Thamsanqa, and Thulani Shabalala.)
The group quickly became one of the most renowned isicathamiya groups around, winning contests all across the country. (The word mambazo means "ax," a reference to the group's ability to cut down the competition; Ladysmith refers to the town most of the members hail from.)
Despite their popularity with South African blacks, Ladysmith remained a local folk group; it never occurred to anyone in South Africa at that time that you could make money by recording black music.
That all changed, however, in 1970. A radio engineer made a recording of Ladysmith performing Nomathemba, Shabalala's first composition, on a live radio broadcast. Almost immediately the song became a sensation.
"The radio stations were getting calls to play that song over and over until they said, 'No, we need a record from these guys.' We didn't know anything about records," Shabalala says.
Over the next 15 years, Ladysmith become one of the most successful groups in South Africa (perhaps the first black success), recording 25 albums during that span. But outside of South Africa, a country that because of its racist government policies was a political and cultural pariah in the international community, Ladysmith was scarcely known at all.
Then in 1985, the Vulindella ("he who opened the gate") came. American singer/songwriter Paul Simon, coming off his career nadir with the disappointingly received One Trick Pony and Hearts and Bones, came to South Africa inspired by a bootleg tape of South African music. One of the first groups he contacted there was Ladysmith.
The sessions that came out of Simon's trip to South Africa became the ground-breaking album Graceland. Featuring, Ladysmith on two tracks – "Homeless" and "Diamonds On The Soles Of Her Shoes" – the album turned the group into into an international smash, allowing them to tour all across the world.
Though an unqualified artistic and commercial success, the Graceland project also brought a firestorm of controversy and criticism upon both Simon and Shabalala.
At the time of the recording sessions, almost every country on Earth was observing a strict cultural and commercial boycott of South Africa as a protest against apartheid, a boycott that Simon had to break in order to work with Shabalala and Ladysmith.
Meanwhile, activists in the anti-apartheid movement attacked Shaba-lala for not using his greater international exposure as a political platform.
"I am a musician," Shabalala says. "Paul Simon is a musician; he's not a politician. He was just trying to take something beautiful and take it somewhere else. Politicians have nothing to do with beauty."
Well, maybe not, but they know it when they hear it. One of Ladysmith's biggest fans is South African president Nelson Mandela. The group accompanied Mandela, at his request, to Sweden in December 1993 when the then-African National Congress leader went to accept the Nobel Peace Prize he shared with then-South African president F.W. de Klerk. And they were at his side again, scarcely six months later, when Mandela was inaugurated president of South Africa.
"[Mandela] loves Black Mambazo," Shabalala says. "According to him we're supposed to be everywhere. Whenever he shows up at a public occasion he asks 'Where is Ladysmith Black Mambazo?' And when they tell them 'No, they're not here; they're on tour.' He goes, 'Oh, no. We have to have Ladysmith Black Mambazo.'"
Today, Ladysmith is as popular as ever and, in many ways, more important than ever. During the days of apartheid, isicathamiya was an important source of hope for the oppressed blacks of South Africa and a way for them to retain their cultural identity. Now, with a newfound sense of self-determination, the spirit of tradition represented by isicathamiya has become essential so that the country's young people don't lose their way in a society that puts no limits upon them.
This is why Shabalala has become a teacher, working to pass on the largely unwritten art that he has worked on his whole life. He is an associate professor of ethnomusicology at the University of Natal and dreams of opening an academy of African music and culture. He also regularly goes out into the schools to teach younger children.
"Now everything is beautiful, Shabalala says. "Since we have this freedom, people realize they have the time and freedom to teach their children African traditions. … But this [music] is not just for Africans or Zulu people. It's not just for Ladysmith people. This is something for everyone."
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text:
Gustav Neumann, né le  à Rathenow et mort le  à Eberswalde, est un géographe et enseignant prussien.

Biographie
Neumann est le fils d'un enseignant et étudie à l'école des professeurs de Marienbourg de 1849 à 1852. Il occupe ensuite temporairement des postes d'enseignant à Riesenburg, Tauroggen, Strasbourg-en-Prusse-Occidentale, Berlin et Anklam. À partir de 1857, il travaille comme enseignant à Neustadt-Eberswalde. En plus de quelques petits traités d'histoire locale, il écrit des ouvrages de référence sur la géographie de l'Allemagne et un manuel de géographie.

Travaux
 Geographie des Preußischen Staates (1866–1869)
 Das Deutsche Reich in geographischer, statistischer und topographischer Beziehung. Zwei Bände. Berlin 1874
 Band 1 (2. Auflage der Geographie des Preußischen Staates), G. F. O. Müller, Berlin 1874
 Band 2, G. F. O. Müller, Berlin 1874
 Schul-Geographie. G. W. F. Müller, Berlin 1881.
 Geographisches Lexikon des Deutschen Reiches: mit Ravensteins Spezialatlas von Deutschland, vielen Stadtplänen, statistischen Karten, Tabellen und mehreren hundert Abbildungen deutscher Staaten- und Städtewappen. Bibliographisches Institut, Leipzig 1883 (1413 Seiten).

Références

Bibliographie
 : Lexikon der Pädagogik. Bibliographisches Institut, Leipzig 1884, S. 307.

Liens externes

Géographe prussien
Naissance en mars 1832
Naissance à Rathenow
Naissance dans la province de Brandebourg
Décès en juillet 1885
Décès à Eberswalde
Décès dans la province de Brandebourg
Décès à 53 ans


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text:
Home Larry Nance Jr. Luke Walton Calls Larry Nance Jr. 'Most Impactful Player' In Win Over 76ers
Luke Walton Calls Larry Nance Jr. 'Most Impactful Player' In Win Over 76ers
Metta World Peace Reflects On Winning A Championship With The Lakers
The losing streak has finally come to an end. The Los Angeles Lakers were able to snap their eight-game skid with a much-needed win over the Philadelphia 76ers on Friday night with Larry Nance Jr. helping guide them to victory on the road.
— Get 15% off everything in the Lakers Nation Store right now by using the promo code 'Lakers' —
Although he finished with only four points, the second-year forward's impact was felt all over the floor. Head coach Luke Walton praised the Wyoming product for his performance following the win over the 76ers, via the Lakers Twitter account:
Luke Walton on @Larrydn22: "He was probably our most impactful player out there tonight."
— Los Angeles Lakers (@Lakers) December 17, 2016
The first win in nine games for the Lakers was anything but pretty. After taking a 13-point lead into the halftime, Los Angeles seemed to be in complete control. The Lakers got some solid efforts from D'Angelo Russell and Julius Randle in the first half but struggled to maintain the lead in the final two quarters in Philadelphia.
Nance, however, was solid throughout the game doing all the little things which he does so well these days. The 23-year-old finished the game with 11 rebounds, two blocks, an assist and a steal in 34 minutes off the bench.
Nance may not light the scoreboard on a nightly basis, but his impact is felt every single game with his ability to do a lot of different things on the floor. His versatility has been extremely valuable to this team and will continue to be part of the backbone of this squad, and his activity on the defensive end has been invaluable.
With the long losing streak now over, the Lakers will try to take some momentum in Saturday's game against the defending NBA champion Cleveland Cavaliers.
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Lakers Injury News: Ivica Zubac Will Undergo MRI After Inconclusive X-Rays On Finger
While the Los Angeles Lakers came away with an impressive blowout win over the Golden State Warriors on Christmas Day, Oracle Arena has been something…
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Lakers Draft News: Australian PG Dante Exum Declares For Draft
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text:
function generate(args::Dict)
  file_type = args["<generator>"]
  file_name = args["<name>"]
  file_params = args["<field>"]

  generate(file_type, file_name, file_params...)
end

function generate(file_type, file_name, file_params...)

  if file_type == "init"
    touch("$(pwd())/config/initializers/$file_name.jl")
    return
  end

  if file_type == "task"
    file_abs_path = "$(pwd())/lib/tasks/$file_name.jl"

    template_file = generate_file_template("src", "function", file_name, file_params)

    open(file_abs_path, "w") do file
      write(file, template_file)
    end

    return
  end

  parent_folders = [
    "src",
    "test"
  ]

  for parent_folder in parent_folders
    suffix = ( parent_folder == "test" ) ? "_test" : ""
    file_rel_path = "$(pluralize(file_type))/$file_name$suffix.jl"
    file_abs_path = "$(pwd())/$parent_folder/$file_rel_path"

    if isfile(file_abs_path)
      answer = user_input("Do you want to overwrite $file_rel_path? [y/n] ");
      if strip(lowercase(answer)) != "y" ; continue ; end
    end

    nested_path, parsed_file_name = contains(file_name, "/") ?
      rsplit(file_name, "/"; limit=2) : ("", file_name)

    parsed_file_name = String(parsed_file_name)

    current_nested_path = ""
    for nested_ancestor in split(nested_path, "/")
      current_nested_path = "$current_nested_path/$nested_ancestor"
      folder_path = "$(pwd())/$parent_folder/$(pluralize(file_type))$current_nested_path"

      if isdir(folder_path) ; continue ; end
      mkdir(folder_path)
    end

    template_file = generate_file_template(parent_folder, file_type, parsed_file_name, file_params)

    open(file_abs_path, "w") do file
      write(file, template_file)
    end
  end

end


When you buy a Firmadoor® Roll-Up door, you're buying the best in value at an affordable price. A Firmadoor garage door will enhance your home without breaking the budget. Each door is custom made to suit your home and comes with a range of features that deliver affordable strength and durability.


By Tony Bacigalupo of New Work Cities.
I and my board are all working on being more strategic about choosing what we do, and who is doing it, but for now, we are still pushing ourselves out of a bit of a rut and I haven't quite found the traction I need.
Here's my main difficulties time-wise. Running this place and having a consistent voice on social media (ie: giving our programs the best marketing we can) is a FT effort.
But, getting out into the community to meet people would also be at least a 1/2 time effort, and we also need to look for funding which that in and of itself could easily be a FT job.
I don't know how to begin to tackle all of our needs, and stay engaged with the coworkers we do currently have.
It's no surprise that anyone getting into managing a space would come up against these sorts of issues, but it doesn't make the situation any more acceptable.
So how do you tackle a situation where everything seems important, yet there just aren't enough resources to go around?
If you find yourself in a similar situation, I suggest you look at each component and identify all the ways you can go about it in a more clever way.
Focus on human interactions over social media.
Social media can consume an unlimited amount of time and attention, competing with countless others all over earth in an arms race for who can be noisiest. I'm not a fan.
Don't play a game you can't win. Change the game. The beauty of coworking resides in the fact that it happens in real life, face-to-face.
So take a social media holiday for a day, or two days, or a week, and instead dedicate that time to just talking to real humans in your space or in other communities.
I remember distinctly one day I was mucking around for hours with MailChimp for a newsletter that was several days overdue, lamenting to myself, "how do I connect with the members and get them to actually show up and care?"… and as I was doing this, I was repelling members who wanted to come up and have a conversation with me. Because I was too busy trying to figure out how to connect with the members. DUH!
So I started practicing getting away from the screen and hanging out in the kitchen. Almost immediately I ended up having conversations with people, learning more about them, and doing a lot of good. One member wanted to organize a new group and had no idea she was empowered to do so within our space. That group was an awesome part of our community for a long time, but it only happened because I talked to her.
Integrate participation into the onboarding process.
When people join the space simply to rent workspace, you immediately have an uphill battle trying to get past their "I'm too busy" wall. Instead, shift the reason someone joins away from space and towards a more transformative program.
Talk to your members. Identify their interests and look for opportunities to encourage and empower them wherever possible. When those members start organizing activities in the space, do whatever you can to invite potential new members to participate.
When people start developing a relationship with your community first through a shared activity, like a happy hour, show and tell, work sprint, arts and crafts session, hackathon, or any of a number of other things, they'll understand right from the onset that what you're managing is something more than just a workspace.
Set aside time for admin things.
Everyone needs focus time to do the non-social things that make a business run. Wherever possible, set aside blocks of time to work on these sorts of things, and communicate that to your team and members, so they know to leave you alone during those times.
For an added bonus, invite others to join you! You can do group sessions where everyone who participates resolves to use the same block of time for focus work. This helps keep everyone in line and makes it easier to block out distractions.
If you have a team, you can rotate who's on Focus Time so others can cover any questions or issues that come up.
Balancing community building against operations is a constant effort, but with some basic healthy best practices, you should be able to make it work!


text:
Mars rover "Pasteur" received a device to search for Martian life
by space · May 25, 2018
The engineering teams of NASA and ESA have completed the assembly of the unique MOMA laboratory that will work aboard the European Pasteur rover and search for traces of extraterrestrial life on Mars, the Goddard Space Flight Center of NASA.
"The rover rover will allow us to obtain rock samples from a depth of up to two meters.In these ancient breeds of Mars can hide organic compounds and other traces of life that could exist on the red planet in the distant past," said Will Brinckerhoff, project manager MOMA from NASA.
In the spring of 2012, the European Space Agency and Roscosmos agreed to jointly implement the ExoMars program. The project consists of two parts – the probe Trace Gas Orbiter (TGO) and the rover, equipped with a number of Russian scientific instruments.
The first device was sent to Mars in March 2016 with the help of the Russian Proton rocket, and the second – sits on the surface of Mars with the help of a special landing system, created in the NGO them. Lavochkin. The mission of the rover is geological research and search for traces of life near the landing site, and the probe will study the traces of rare substances in the atmosphere of Mars and search for deposits of water ice.
Both the platform and the rover will be equipped with both European and Russian scientific instruments intended for geological and chemical research. One of such instruments will be a soil chemical analyzer, developed by a group of scientists from Moscow State University, Institute of International Relations and MISIS under the leadership of Oleg Korablev from the Space Research Institute of the Russian Academy of Sciences.
The MOMA laboratory, the largest scientific component of Pasteur equipped with several spectrometers and chromatographs, will play a similar role from the European and American sides. It was developed at the Institute for the Study of the Solar System in Göttingen (Germany), with the assistance of NASA and ESA.
The key part of this device is a miniature mass spectrometer with the help of which scientists hope for the first time to accurately study the chemical composition of the most ancient samples of Martian soil and understand what organic molecules are contained in it. To do this, Pasteur will heat the soil samples in a special "furnace" and fire them with a laser, forcing these substances to leave the ground and pass through a mass spectrometer.
Unlike all other chemical laboratories working on satellites and other rovers today, MOMA will be able to determine the direction in which the molecules passed through it are "twisted". This turns it into a real "life detector", since all molecules of amino acids in living organisms, as well as sugar, are turned only to the left or right side.
As the scientists hope, the two-meter-long Mars rover and MOMA will help to find not only potential traces of ancient life on Mars, but also "living" microbes that can hide a few meters below the surface where cosmic particles and solar ultraviolet do not penetrate, and where liquid water may be present.
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Peripheral arterial disease is a common condition in older adults involving poor arterial circulation in the legs leading to leg pain and debility. The body's own circulating blood vessel stem cells may help to improve circulation. This study will test whether treatment with the drug granulocyte macrophage colony stimulating factor (GM-CSF) will improve symptoms and signs of peripheral arterial disease over placebo after four weeks of therapy. As well this study will examine whether improvements in blood vessel function can be observed. Finally, we will measure blood vessel function and stem cell levels in order to determine whether they can help to predict whether patients wither peripheral arterial disease will suffer further cardiovascular complications.
Peripheral artery disease (PAD) affects more than 8 million Americans. Although exercise, smoking cessation, anti-platelet therapy, cilostazol, statins and revascularization are used to treat PAD, men and women with PAD have significantly greater functional impairment and fasterfunctional decline than those without PAD. Stem and progenitor cell (PC) therapy that promotes neoangiogenesis is an emerging treatment modality in PAD. Progenitor cells, particularly those of endothelial origin, are involved in vascular repair and regeneration. They originate primarily but not exclusively from the bone marrow, differentiate into endothelial and other vascular cells, and contribute to neovascularization during tissue repair by direct and paracrine mechanisms. Endogenous, pharmacologically-stimulated, and exogenous PCs contribute to re-endothelialization and neovascularization. Granulocyte colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) stimulate mobilization of hematopoietic and other PCs from the bone marrow.In the murine hind limb ischemia model, GM-CSF administered by injection or by plasmid transfer augments circulating levels of PCs, increases capillary density, and promotes arteriogenesis.GM-CSF also augments neo-endothelialization of denuded arteries, promotes proliferation, differentiation and survival of hematopoietic cells, monocytes and macrophages.
Exercise Tolerance Test (ETT) was conducted using the Gardner protocol. Participants exercised on a treadmill, starting at 2.0 mph. The intensity of exercise (speed) was increased in grade of 2% every 2 minutes. Participants were asked to exercise until symptom limitation and the time measured in seconds from the ETT was used for data analysis.
Claudication is pain, tired or weak feeling that occurs in the legs, usually during activity such as walking. The COT was measured as the time to onset of the participant's typical claudication as the maximum distance the patient could walk on the treadmill.
The WIQ quantifies walking difficulty on a 100-point scale, in which 0 indicates extreme difficulty and 100 indicates no difficulty with walking distance.
The WIQ quantifies walking difficulty on a 100-point scale, in which 0 indicates extreme difficulty and 100 indicates no difficulty with walking speed.
The WIQ quantifies walking difficulty on a 100-point scale, in which 0 indicates extreme difficulty and 100 indicates no difficulty with stair climbing elements.
The SF-36 is a standard quality of life instrument. The PCS represents the the physical burden on quality of life and is a summary of questions related to physical impact of a disease or condition (physical function, role physical, bodily pain, and general health). PCS is a summary measure derived from 8 scale score and the score ranges from 0-100; higher scores indicate better performance.
The SF-36 is a standard quality of life instrument. The MCS represents the the mental burden on quality of life and is a summary of questions related to mental impact of a disease or condition (mental function, role emotional, vitality, and mental health). MCS is a summary measure derived from 8 scale score and the score ranges from 0-100; higher scores indicate better performance.
The SF-36 is a standard quality of life instrument. The physical functioning represents limitations in physical activities because of health problems. Physical functioning is a summary measure derived from 8 scale scores and the score ranges from 0-100; higher scores indicate better performance.
160 males or post-menopausal females between 21 and 80 years of age. Female subjects must be (a) post-menopausal, (b) surgically sterile or (c) use adequate birth control and have a negative pregnancy test within 3 days prior to administration of study drug and should not be breastfeeding.
Clinically stable (at least 2 months) history of intermittent claudication with no change in symptom severity in the 2 months prior to screening.
On stable statin therapy for previous 3 months.
Peak Walking Time (PWT) between 1 and 12 minutes on a standardized Gardner treadmill protocol.
A Doppler-derived ankle-brachial index (ABI) of < 0.85 in the symptomatic limb after 10 minutes of rest at screening. For subjects with an ABI of >1.3 (non-compressible arteries) a Toe-Brachial Index (TBI) of < 0.70 must be obtained for subject qualification, or if ABI is > 0.85 to 1.0 , and a reduction of 20% in ABI measured within 1 minute of treadmill testing.
On appropriate and stable medical therapy for atherosclerosis for at least 2 months.
Diabetics with a dilated eye exam excluding proliferative retinopathy in the previous 12 months.
Recent or current active infections (treated with antibiotics).
Critical limb ischemia either chronic (category 3 and 4 of SVS classification) or acute ischemia manifested by rest pain, ulceration, or gangrene.
Lower extremity vascular surgery, angioplasty or lumbar sympathectomy within 3 months of enrollment.
Participation in a structured exercise treatment protocol within 3 months of enrollment.
Unstable angina, myocardial infarction, TIA, stroke or revascularization in the preceding 4 months.
Severe heart failure (Class III or IV), heart muscle disease or atrial fibrillation.
Limitation on exercise for symptoms other than intermittent claudication such as arthritis or dyspnea.
Uncontrolled diabetes mellitus (defined as HbA1c > 10.0).
Chronic renal disease (creatinine of >2.5 mg/dl) or hepatic disease (> 3 X elevations in AST and ALT).
Ophthalmologic conditions associated with a neo-vascular response.
Poole J, Mavromatis K, Binongo JN, Khan A, Li Q, Khayata M, Rocco E, Topel M, Zhang X, Brown C, Corriere MA, Murrow J, Sher S, Clement S, Ashraf K, Rashed A, Kabbany T, Neuman R, Morris A, Ali A, Hayek S, Oshinski J, Yoon YS, Waller EK, Quyyumi AA. Effect of progenitor cell mobilization with granulocyte-macrophage colony-stimulating factor in patients with peripheral artery disease: a randomized clinical trial. JAMA. 2013 Dec 25;310(24):2631-9. doi: 10.1001/jama.2013.282540.