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Arts102111
Wartime love, escape propel immersive Remembrance
By Michael Fox | October 21, 2011
To those who swore they'd seen enough Holocaust-themed films to last a lifetime: Rescind your vow, just this once.
The German drama "Remembrance" ("Die verlorene Zeit") is that good. It's better than good, in fact. It's unforgettable.
Anna Justice's fact-based saga relates a tale of escape from war-torn Poland nearly as incredible as Agnieszka Holland's jaw-dropping "Europa Europa" did two decades ago. At the same time, "Remembrance" cuts between the past and the present (circa 1976) with far greater emotional force than the recent "Sarah's Key" mustered.
The epic German drama "Remembrance" tells of lovers bound by war and reunited by happenstance. photo/cornith films
The generator of all that power is a pressure-cooker love affair portrayed with such urgency, immediacy and intensity that it makes every screen romance you've seen in the last 10 years look like a foolish game of charades.
In other words, "Remembrance" is the whole package. This is the rare film that's epic in scale and reach, yet effortlessly capable of touching every viewer.
"Remembrance" receives its North American premiere Tuesday, Oct. 25 in the Berlin & Beyond Film Festival at the Castro Theatre, in a co-presentation with the San Francisco Jewish Film Festival and the honorary consul of Poland. The film is preceded by Werner Biedermann's seven-minute short "Laula," an artful ode to his relatives who perished in the Holocaust.
The other Jewish-related film in the festival, "100 Years of Hollywood: The Carl Laemmle Story," plays at 2:30 p.m. Wednesday, Oct. 26, also at the Castro.
"Remembrance" begins in a gray concentration camp in Poland in 1944, where German Jew Hannah Silberstein (Alice Dwyer) scrubs floors in the bakery and tries to be invisible. That's the best survival strategy, she's learned, and her mastery of it is a big reason she makes it through the war.
I'm not giving anything away, for we're immediately, and jarringly, shown her comfortable life in Brooklyn. Now Hannah Levine (Dagmar Manzel), she's picking up a tablecloth from her neighborhood cleaners for a party that night when she's stunned to overhear a television interview with a middle-age Polish ex-partisan.
Her world thrown off its axis, Hannah spends the evening ricocheting between frantic action and distracted reverie, to her husband's puzzlement and frustration.
Tomasz Limanowski, the gentle non-Jew Hannah glimpsed on TV, is the other reason she's alive. He was a fellow prisoner and they were secret lovers — which may sound impossible but is presented in an utterly convincing manner. (Bribery, along with Nazi efficiency and fear, kept the camps running, apparently.)
A plan has been concocted to spring Tomasz from the camp with a roll of film exposing Nazi abuses. In an impulsive and breathtaking act of courage and devotion, he takes Hannah with him.
Pam Katz's smart script deals with familiar Holocaust themes — trust and betrayal, Polish anti-Semitism, memory and regret, the unwillingness of survivors to discuss the past — pithily and succinctly. We're told very little but we see everything, in a glance, a gesture or one of the director's powerfully elegant compositions.
The film purposely throws us into the middle of situations, forcing us to make snap judgments along with Hannah and Tomasz. This approach also has the effect of ratcheting the tension during their flight, a significant accomplishment given that we know their lucky fate at the outset.
The upshot is that it's impossible to be a passive viewer of "Remembrance." Fortunately, Justice ("Max Minsky and Me") and Katz are diligent about rewarding our emotional commitment.
They have crafted a Holocaust saga that hits unusual and unexpected notes, and they've imbued a cross-cultural love story with historical insight and depth. From beginning to end, from top to bottom, "Remembrance" is an immersive, intelligent and altogether satisfying experience.
See it, then go ahead and make a new promise.
"Remembrance" screens at 6 p.m. Tuesday, Oct. 25 at the Castro Theatre in San Francisco. In German and English with English subtitles. (Not rated, 105 minutes)
Michael Fox is a longtime film journalist and critic, and a member of the San Francisco Film Critics Circle. He is the curator and host of the CinemaLit film series at the Mechanics' Institute and teaches documentary classes at the Osher Lifelong Learning Institute programs at U.C. Berkeley and S.F. State. In 2015, the San Francisco Film Society added Fox to Essential SF, its ongoing compendium of the Bay Area film community's most vital figures and institutions.
San Mateo man escaped from Auschwitz — his story is on film
TV drama reopens debate about Germans war guilt
In WWII, they were 'Invisibles,' but the film is something to be seen
From Generation to Generation: Familial memories become contemporary art in CJM exhibit


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Developmental Team
Gass Shines in Doubleheader versus Southern Wesleyan
Southern Wesleyan (11-15, 4-6) 1 0 2 2 0 0 0 5 7 2
Belmont Abbey (13-15, 3-5) 0 3 0 0 0 1 0 4 11 1
Southern Wesleyan (10-15, 3-6) 0 1 5 0 1 1 8 9 0
Belmont Abbey (13-14, 3-4) 0 0 0 0 0 0 0 5 3
2B: Delaney Byers; Megan New; Amber Belk
2B: Delaney Byers; Lexi Thompson
HR: Lydia Clanton
2B: Claire Doyle
BELMONT, N.C. -- Freshman Hailey Gass had five hits in seven at-bats Saturday, highlighting Belmont Abbey's performance in a Conference Carolinas doubleheader against Southern Wesleyan on Saturday. The Warriors won both games, however, taking the first 8-0 in six innings before rallying for a 5-4 win in the nightcap.
Belmont Abbey falls to 13-15 overall and 3-5 in league play, while Southern Wesleyan advances to 11-15, 4-6.
Gass had a pair of singles for her fourth multi-hit game of the season.
Claire Doyle doubled and Melissa Neyhouse and Payton Whitley each had hits.
Southern Wesleyan plated a run in the second before adding five in the third, primarily on the strength of a three-run homer.
Single runs in the fifth and sixth ended the game early.
Starter Annabeth Watkins (7-7) took the loss, allowing four runs on five hits over two innings.
Delanie Laudenbacher (4-6) pitched a complete-game shutout for the Warriors. She walked four and struck out four.
Gass went 3-for-4 with an RBI, recording at least two hits for the fifth time this year.
Peyton Wilson and Brianna Embler registered two hits each for the Crusaders, who totaled 11 in the contest.
Southern Wesleyan struck for a sacrifice fly in the first, but The Abbey answered with a three-run second. Three straight singles with one out, the last by Alexis Rogers, tied the score at 1. After another single loaded the bases, Doyle flied out to right before Gass reached on an infield hit.
But the Warriors delivered a pair of two-run doubles, one in the third to tie the game and another in the fourth to move back in front.
The Abbey tried to rally, putting runners on the corners with one out in the sixth. Neyhouse drove in a run on a flyball to left, but the tying run was left at second by an outstanding play on a comebacker to Ashton Martin.
Belmont Abbey starter Ivorie Maltby struck out seven, but allowed five runs (three earned) in 5.1 innings. She falls to 4-6 with the loss.
Martin evened her record at 6-6 with the win, while Emma Collins pitched the seventh for her second save.
Belmont Abbey continues Conference Carolinas play on Tuesday when it travels to Mount Olive.
Sat, 04/27 | Softball vs. No. 2 seed King L, 7-1 (Final) RC | BX
Fri, 04/26 | Softball vs. No. 6 seed Southern Wesleyan L, 4-2 (Final) RC | BX
Fri, 04/26 | Softball vs. No. 2 seed King W, 5-2 (Final) RC | BX
Mon, 04/22 | Softball at Young Harris (Cancelled)

redpajama_set_name: RedPajamaCommonCrawl


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Retroacta van de Burgerlijke Stand zijn de registers waarin de kerkelijke bevolkingsadministratie tot aan de invoering van de burgerlijke stand werd bijgehouden. In België spreekt men van "parochieregister" of "Registre paroissial" en in het Duits kortweg "Kirchenbuch". Nederlandse genealogen duiden ze aan met DTB-registers (doop-, trouw- en begraafregisters).

Geschiedenis
Het Concilie van Trente verplichtte op 11 november 1563 de parochiepriesters om doop- en huwelijksregisters aan te maken, wat in feite neerkwam op de veralgemening van bestaande maar disparate praktijken. In Bourgondië zijn parochieregisters bewaard die teruggaan tot 1334. De oudste reeks voor België is het huwelijks- en verlovingsregister van de Brusselse Sint-Michielsparochie, begonnen in 1482. Later werden ook overlijdens-/begrafenisregisters gemaakt, hoewel daarvoor geen bindende voorschriften bestonden. Het oudste begrafenisregister van de Sint-Michielsparochie in Leuven, destijds de hoofdstad van het oude Hertogdom Brabant, start in 1540. Ook de protestantse kerken zijn tot bevolkingsregistratie overgegaan. Het oudste doopboek van Nederland begint in 1564 (Amsterdam), het oudste trouwregister zelfs al in 1542 (Deventer).

De praktijk was weerbarstiger dan de wetgeving. Vooral in kleinere parochies kwam de registratie pas in de 17e eeuw op gang. In de Spaanse Nederlanden was het Eeuwig Edict van 1611 een belangrijke stap in de veralgemening van de registratiepraktijk.

In kleinere gemeentes werden de verschillende soorten registers soms in één fysiek boek samengevoegd.

Bij de invoering van de burgerlijke stand moesten de kerken hun registers bij de overheid inleveren. Zij dienden als basis voor de nieuwe registers van de burgerlijke stand. Dit betekende echter niet het einde van de kerkelijke administratie. Ook na de invoering van de Burgerlijke Stand bleven de kerken hun dopen en dergelijke registreren, maar deze werden niet meer gebruikt ten behoeve van de bevolkingsboekhouding.

Voor de Nederlandse situatie heeft de toenmalige directeur van het Centraal Bureau voor Genealogie, Wijnaendts van Resandt, in het zogenaamde Repertorium DTB per afzonderlijke plaats beschreven welke registers bewaard zijn gebleven.

Doopboeken
In de doopboeken staat meestal de voornaam van de dopeling, de doopdatum en de naam van de vader en de moeder. Vaak worden ook de namen van de peter en meter vermeld (in niet rooms-katholieke registers aangeduid als getuigen). Als het kind een vondeling was of als de ouders niet gehuwd waren is dit vaak vermeld in de akte.

De informatie in een doopboek kan echter sterk verschillen, zowel per plaats als per tijd. In het algemeen geven latere registers meer informatie, zoals de geboortedatum. Het noemen van de getuigen was bij protestantse kerken in Nederland gebruikelijker in het westen dan in het oosten en noorden.

Trouwboeken
In een trouwboek staan meestal de datum van ondertrouw en/of van het huwelijk en/of de datum van attestatie om elders te trouwen, de huwelijksafkondigingen en de voor- en familienaam (en/of patroniem) van de huwelijkspartners. Bij attestaties wordt meestal aangegeven waar het huwelijk zal plaatsvinden. Ook wordt dikwijls aangegeven of de huwelijkspartners al dan niet eerder gehuwd waren geweest. Vaak is ook de plaats van waar zij afkomstig zijn vermeld. Ondertrouwen werden ingeschreven in het huwelijksregister. Vanaf de 18e eeuw werden soms ook de namen van de huwelijksgetuigen en van de ouders van de bruid en bruidegom vermeld. Huwelijken die in de kerk werden gesloten staan vermeld in de kerkelijke trouwboeken. Daarnaast werden de huwelijken die gesloten werden voor de schepenen in afzonderlijke trouwboeken geregistreerd.

Begraafboeken
In een begraafboek staat in het algemeen de naam van de overledene en datum van de begrafenis. Bij de kinderen kan de naam van de ouders staan. Bij volwassenen is vaak de naam van de partner vermeld, vooral als de overledene een vrouw is. Ook wordt in sommige gevallen de plaats van het graf in de kerk genoemd.

Gaardersregisters
De gaardersregisters bevatten de informatie over de belasting (impost) die moest worden afgedragen bij het sluiten van een huwelijk en bij het begraven. Vaak werden de namen ook vermeld als de belasting nihil was. De huwelijksregisters bevatten de namen van de huwelijkspartners, de huwelijksdatum en/of de registratiedatum, de hoogte van de belasting en soms ook aanvullende gegevens, zoals burgerlijke staat en geboorteplaats. De begraafregisters bevatten de namen van de overledenen, de hoogte van de belasting, de begraafdatum en/of de registratiedatum en soms ook leeftijden en/of adres van de overledenen.

Besnijdenisregisters
Hoewel feitelijk geen doop, worden Joodse besnijdenisregisters ook tot de DTB gerekend.

Externe link
Belgische parochieregisters on-line (Algemeen Rijksarchief)

Genealogie
Historische bron

redpajama_set_name: RedPajamaWikipedia


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Charles Edward Daniels (1884-1967)
Charles Edward Daniels
Fitzroy, Victoria
Mrs C Daniels
Professional soldier
"Charles Edward Daniels (1884-1967)," Wyndham History, accessed January 20, 2021, http://www.wyndhamhistory.net.au/items/show/2155.
Daniels, Charles Edward
No.92 Charles Edward Daniels
Charles Edward Daniels was born in Fitzroy, Victoria on 1 December 1884.
At the time of his enlistment at Maribyrnong on 18 August 1914, he had served as a professional soldier for more than three and a half years. Despite this service, he was still required to go through the attestation process to be accepted as a volunteer in the fledgling AIF.
It's not known what his rank was or with which unit he served prior to enlisting, but he was made a Gunner and assigned to the 1st Australian Field Artillery Brigade. There is a note on one set of attestation papers that the 'soldier's address' was the Royal Military College at Duntroon, perhaps suggesting that he was being trained as an officer before the outbreak of the war.
His next of kin was his mother, Mrs C Daniels who was living at South Yarra.
He left Australia on 18 October 1914 in the first of many convoys to leave our shores that were to deliver soldiers to war zones in the Middle East and Europe. He was aboard the HMAT Argyllshire – one of 38 Australian and 10 New Zealand troopships that gathered in Albany in Western Australia to begin their dangerous voyage to Egypt. They carried 30,000 troops and thousands more horses.
The war was never very far away. Within days of leaving Albany, the soldiers heard of the famous victory by HMAS Sydney against the German light cruiser Emden, that was forced aground in the Cocos Keeling Islands. Its danger can be assessed by its tally of victims. Since the war began in early August 1914, the Emden had captured or sunk 21 allied vessels.
The convoy reached Egypt in early December 1914. Their time between their arrival in Egypt and their departure for Lemnos - an island group in the North Aegean Sea that was to serve as a staging post for the landings at Gallipoli - was spent largely in training.
The story about the role of artillery in the early days of the landings is confusing. Individual guns were unloaded on the second day of the assault, but were then reloaded back onto ships. The 18 pounders (which relates to the size of the shell they fired) were deployed singly because of the lack of suitable firing positions. At a later stage, a battery of howitzers was brought ashore to support the infantry.
By the time that Charles Daniels was on the beach, he had already been promoted to Bombardier – a non-commissioned rank equivalent to a Lance-Corporal in other army units. Unfortunately, there is no record of what Bombardier Daniels experienced in the Dardanelles. He and his unit would have been in support of many of the largely inconclusive and costly assaults that took place between 25 April and when most of the allied forces were evacuated just prior to Christmas 1915.
By the time his unit arrived back in Egypt on December 22 1915, Charles had been promoted to Sergeant.
The 'labelling' of artillery units at this juncture of the war was confusing. It would appear that Charles was transferred to '54 Battery', which was part of the 14th Field Artillery Brigade.
He was promoted to Battery Sergeant Major in May 1916. Just over a month later, he and his men found themselves on the move once again – this time, to Marseilles on the southern coast of France and then onto the Western Front where they formed part of the Australian 5th Division.
Tracking the events of artillery units during World War I presents a greater challenge than that of their infantry counterparts. Battery Sergeant Major Daniels personal record isn't particularly illuminating either.
We have made the presumption that the battery maintained its links with the 5th Division and as a consequence, Charles and his men would have been involved in some of the bloodiest battles of the war. In 1916, at Fromelles in the Somme…in 1917, the German retreat to the Hindenburg Line and the battle of Bullecourt in France, and in Belgium between September and November, the battles of Menin Road, Polygon Wood and two assaults on Passchendaele.
In 1918, the 5th Division was active largely in France, participating in numerous large-scale actions including Villers-Bretonneux and battles of the Hindenburg Line that virtually spelt the end of German resistance following the failure of their Spring Offensive earlier in the year.
What we do know is that Battery Sergeant Major Charles Edward Daniels' leadership qualities had not gone unnoticed. On 8 March 1918, he was awarded the Meritorious Service Medal. The citation reads: "Throughout the period 22nd September 1917 to 25th February 1918, this Warrant Officer has been conspicuous by the thoroughly efficient manner in which he has performed his duties. During the operations east of Ypres, September-October 1917, owing to casualties on several occasions, he has been called upon to replace an Officer and this he has done with credit. His devotion to duty and meritorious service is worthy of recognition."
Charles left the frontline before the Armistice in November 1918. Given that he had served since the first Australians left our shores in October 1914, he was granted an early return to Melbourne arriving back on 23 November. He stayed in the Army until May 1919. For his service, he received the 1914/15 Star, the British War Medal and the Victory Medal.
He applied for the Anzac Commemorative Medallion designed to recognise the service of all surviving Gallipoli veterans. The medallion features on one side Simpson and his donkey – one of the most enduring symbols of World War I – and on its reverse, a map of Australia and New Zealand superimposed on the Southern Cross.
Sadly, he passed away in Sydney in June 1967 aged 82 just prior to the medals being issued.
1914/15 Star Medal
NAA: B2455 DANIELS C E
History of Australian artillery units
https://rslvirtualwarmemorial.org.au/explore/units/232
War diary https://www.awm.gov.au/collection/RCDIG1014850/


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The evening sun in Hanover. Photo: DPA.
From a freezing January to a mild February - one expert suggests winter is already over in Germany.
Meteorologist Björn Alexander told broadcaster N-tv on Friday that he predicted an early end to Germany's cold snap.
According to the weatherman, winter in Germany is over (for now). Unusually mild temperatures are expected this coming February, possibly up to 3C higher than average.
While Alexander admits he cannot be 100 percent certain - such is the margin of error in weather predictions - his forecasts are backed up both by American colleagues and Germany's national weather service. An Atlantic depression is set to displace a block of high pressure, leading to milder temperatures and an end to the ice.
This comes after one of the coldest Januaries in the last 30 years. In fact, the average temperature for the month was 1.7C colder than the norm. The effect was especially pronounced in areas of southern Germany such as Bavaria, which recorded a spine-tingling -26C .
And while Germany may be used to difficult weather conditions, that didn't stop the River Danube from icing over in various places. In Nuremberg, its main canal even saw river traffic partially suspended, causing difficulties for shipping companies.
That looks set to end this weekend, however. Alexander predicts temperatures between -4C and up to 10C some western areas for Saturday, while Sunday will be between 2C and 9C across the country. Still, east Bavaria is still expected to be frosty at around -1C.
There are no guarantees, though. Märzwinter is the term used to denote a cold patch which often sweeps Central Europe in March or even April. So don't pack away your snow boots just yet.


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TechCrunch: WhatsApp reveals six previously undisclosed vulnerabilities on new security site
September 3, 2020 / Last updated : September 3, 2020 ResearchBuzz Security & Legal Issues
TechCrunch: WhatsApp reveals six previously undisclosed vulnerabilities on new security site. "Facebook-owned WhatsApp has revealed six previously undisclosed vulnerabilities, which the company has now fixed. The vulnerabilities are being reported on a dedicated security advisory website that will serve as the new resource providing a comprehensive list of WhatsApp security updates and associated Common Vulnerabilities and Exposures (CVE)."
privacysecurityWhatsApp
Baltimore Fishbowl: Maryland Historical Society to relaunch as Maryland Center for History and Culture, open new exhibits


The damper on the side of the flywheel adjusts the airflow in and out of the flywheel on each stroke. On a higher setting, like 10, more air is allowed into the flywheel and will need to be pushed out on each stroke. On a lower setting, less air is exchanged on each stroke. The "best" damper setting—for you!—is a matter of personal preference and what gets you the best results. This may vary with the distance you're rowing and your preferred stroke rate.
First things first: the damper adjusts the airflow, but to accurately compare indoor rowers, you'll want to View Drag Factor. Drag factor is a much better comparison between machines that have different air flows due to things such as dust in the flywheel or elevation. Think of damper and drag as your gearing. The flywheel is a moving wheel, just like on a bicycle. A high damper and drag is like the big chain ring on a bicycle. It requires a lot of effort to get the wheel moving from a stopped position. In comparison, at a lower damper and drag, the flywheel spins more freely, especially on the first few strokes.
On a bicycle, a high gearing will feel slow and sluggish to start. It is difficult to get the pedals at a high revolutions per minute until the wheel is spinning. This style of cycling takes a lot of muscle. Few cyclists would opt for the hardest gear for an entire race—which is why a damper setting of 10 is rarely (if ever) recommended. In contrast, a cyclist on a lower gearing will be able to get the flywheel moving more quickly at the start. Some athletes find it easier to maintain a higher strokes per minute at a lower damper, similar to a higher cadence (rpm) on a bicycle.
In either case, the Concept2 Performance Monitor takes into account your choice of damper and drag into calculating your speed. There is no advantage of one damper over the other for all athletes in all workouts. We recommend experimenting with different workouts to see what works best for you. See what works for the Olympians we interviewed!
We recommend experimenting with different drag factors before race day. Try rowing one minute of work followed by one minute of rest, changing the damper from one to ten on each work segment. Start each work minute from a stopped flywheel and maintain a constant spm. (We aim for 26 or 28 spm.) What feels different, if anything? Does the output change?
Good technique prevails; the Performance Monitor rewards effective rowing at any damper setting and any stroke rate.
A higher damper (and drag) is difficult to sustain with effective technique; use strategically for sprints or short workouts.
High damper and drag settings may lead to injury, since greater force is required to remove the "tank" of air from the flywheel each stroke—especially on the first strokes.
Rowing is cardiovascular; lower damper settings best mimic the sport.
Very low damper settings (like 1) require the athlete to be very quick and light at the catch.
A damper setting of 3-5 is recommended because it provides a comfortable platform for the start and an effective "gearing" for most workouts. A damper setting of 3 is most appropriate for longer workouts. A damper setting of 5 is most appropriate for shorter workouts.
A determined young nurse is preparing to row for 24 hours straight to raise money for the @RCHMelbourne… t.co/dwepKY4MB4 @7NewsMelbourne about 1 week 6 days ago.
Posted by Concept2 1 week 1 day ago.
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Instructions: Pour the contents of this bottle into a 75 cl (US 25 fl oz) bottle. Fill 3/4 full with vodka and shake until the sugar has dissolved. Top up the bottle and shake until the contents have fully blended.
Brandy Mild French is a very popular brandy. Drink neat or mixed with cola or orange juice.
Elderflower Spirits is a spiced elderflower spirit. Drink neat or in tea and coffee.
Gran Vodka is a spiced vodka with the distinct flavour of spruce leaf. Mix with tonic, grapefruit,Schweppe´s Russian etc.
English Gin is a spiced liquor with the distinct flavour of juniper. Mix with tonic, grapefruit, Schweppes© Russian, etc. or try a Dry Martini by mixing Dry Gin with Vermouth.


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Personalities | Slayer | Eighties | Rock
The most extreme of the major thrash metal bands, lyrically and sonically, Tom Araya (bass, vocals), Kerry King and Jeff Hanneman (both guitar) and Dave Lombardo (drums) rejoice in album titles such as Show No Mercy (1984) and 1987's breakthrough Reign In Blood replete with a song about Nazi butcher 'Dr' Mengele. 1994's US Top 10 Divine Intervention was a return to the high-decibel speedcore at which they excel, after a flirtation with slightly more mainstream metal.
Styles & Forms | Eighties | Rock
Personalities | Sly & Robbie | Eighties | Rock


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Absinthe: A Revival of Long-Lost Spirits in New York
Here we met Will Elliott, bar director of Maison Premiere and Sauvage, who over the last six years has guided Maison to be crowned number 20 in The World's 50 Best Bars awards.
Abbie Moulton
María Chu
Take Take a stroll along Williamsburg's bustling Bedford Avenue and you're likely to find your way to the unassuming, quietly elegant Maison Premiere. With its faded-green exterior and pre-prohibition decor, it's a place which is truly transportive in time. The Parisian-esque cocktail den and oyster bar is dipped in New Orleans style - a nod to a more glamorous era of decadence and mischief when absinthe flowed as the bohemian's drink of choice. Inside, a horseshoe-shaped bar and classic absinthe fountain pay homage to the bar's Deep South roots, while outside a twinkling, lush garden provides an oasis that whisks you a million miles from the concrete, metropolitan reality.
A short ramble from Maison Premiere in nearby Greenpoint is sister restaurant, Sauvage. A new addition to the family, this younger sibling is somewhat more wild, with an adventurous menu and more rustic feel. On the night we visited, we approached to find a gorgeous, model figure leaning willow-like against the exterior wall, dragging louchely on her cigarette. We briefly wondered if she'd been hired to stand there to give the place an air of fashion... But on stepping through the door, we realised the crowd inside were equally handsome.
Here we met Will Elliott, bar director of Maison Premiere and Sauvage, who over the last six years has guided Maison to be crowned number 20 in The World's 50 Best Bars awards, as well as picking up the prestigious James Beard Award for Outstanding Bar Program. With a penchant for old and rare liqueurs, and a dress-sense as sharp as his palate, Will is undoubtedly one of New York's most captivating hosts. We sipped a cocktail and settled in to talk absinthe, Arizona and Hermès ties...
How did you begin your journey into spirits and cocktails?
It's a funny road! I could trace it back to being a kid; my parents didn't drink but they kept Pernod for cooking. The first time I remember smelling it - an intense smell which reminded me of jelly beans and liquorice - I guess it opened up my palate to accepting really brave flavours. From then I learnt to enjoy challenging flavours. I started bartending at a young age at a seasonal restaurant off Maine. It wasn't fancy but I spent a good few years there. I was able to do a lot of tasting and take my palate on an adventure - I became fascinated by grappa. I'd spend the other half of my years in Tucson, Arizona where I played music, so I bartended as a way of supporting myself.
You've had a huge year of winning awards and opening a second restaurant. How have you kept up with everything?
Well, it's exhausting! To state the obvious, if you're in it for the winning of awards you're never going to have the energy to keep up with the bigger picture. Maintaining some sort of ongoing rhythm and having a direction, that's important. It's daunting, sometimes it's really humbling; it can be all kind of things. But having a clear, focused direction is key.
Sauvage must feel like a new baby in the family. How do you make sure both bars have their own personality?
Maison started as an oyster and cocktail bar; it has a delicate and ethereal sort of dining. With Sauvage, it's a little lustier with a bigger style of plating and more rustic dishes. The drinks are also more delicate; a lot of the things we make at Sauvage use high-elevation herbal liquors from the French and Swiss Alps - flavourful and indicative of place and time.
You use a lot of rare liquors in that menu, tell us about those?
We make some classics like a really great martini or collins, but the ingredients and spirits make them different. A lot of the things that make these interpretations unique are really kind of nerdy choices in what bottles we're using. I guess a lot of it comes down to sourcing and finding unusual things. Because I think that you can make ordinary cocktails taste rather extraordinary if you just change the tiniest little ingredient.
We can't talk to you without mentioning absinthe. You're credited with its revival in New York...
Yeah, I should mention my good friend Maxwell who was the opening bar manager back at the beginning of Maison. We went through several years of trying to taste as much as we could, as crazy as that sounds…
Those must have been a fun few years!
It is a really beautiful spirit that speaks to terroir just like wine, it's interlocked with wine in a geographic sense. You add five parts water to one part absinthe so you heavily dilute it down to the same alcohol content as a glass of wine. You're sipping it in the same way, it's aromatic, you smell it, you're probably swirling it in the glass. It contradicts all the novelty that surrounds it and reminds you of a more historic context, it reminds you that actually it was started very medicinally. I'm a sucker for history and for a story and absinthe has one of the most amazing lineages over the course of two hundred, three hundred years. I love it.
You even have an absinthe fountain at Maison.
America has a long history of absinthe production that predates prohibition - there are even local styles of absinthe in American cities. New Orleans for us was a huge inspiration. The Old Absinthe House down there is a highly historic bar; every walk of humanity from pirates to presidents have been through that bar and it continues to stay open to this day which is pretty cool. The fountain we have is an exact replica of theirs - it's a spiritual centrepiece.
You're known for your snappy dress sense - rumour has it you have quite a tie collection?! Where do they come from?
I get a kick out of the crossover of fashion and food industries and I'm drawn to the aesthetics. The neckties started unintentionally and now I have two hundred of them. Brooklyn has so many awesome thrift stores, such as Beacon's Closet and Buffalo Exchange. I'm a sucker for Hermès ties so can find all of the good stuff pretty easily and it's usually on the way to work or something.
Will Elliott's Insider Guide to New York
How do you spend a day off?
A bike ride and daytime drinking; The Nomad is great during the day. There's an amazing beer bar called the Spuyten Duyvil where the bar staff love to make you try all the things. There's also Diner, which reminds me of eating at St John Bread & Wine in London due to the sincerity of the food.
What's the best way to explore the city?
Self-guided, unplanned walks around town. Upper Manhattan architecture in super interesting and a weekend walk there is relaxing.
Where do you go for a relaxed dinner?
There's a little Vietnamese place on the border of Ridgewood and Bushwick called Bunker. It started by a couple of very qualified wine buffs, but they're also like skater kids, running the space out of an old garage. It's not quite as sketchy as it sounds! There's a lot of amazing techniques and they serve some of those most flavourful, delicious and crave-able food in the city.
Girl Going Places: Maame Adjei


She knew of no other way to get the message to him but to sneak inside the tomb and leave it there. A red rose would signal it was definitely from her. Waiting for the dark of night, she crept her way in and quietly placed the note on the first soldier, a stone statue, laying on the ground. She never remembered it being knocked over, and oddly, there was not a crack in it. It was as if it had carefully laid itself down on the floor, but stones can't move on their own, she reminded herself.
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text:
Bank BSU or Bank BSU Cooperative is a Swiss regional bank located in  Uster, canton of Zurich. It was founded in 1836 as a savings bank of the district Uster and in 1892 it was registered using the name Sparkasse des Bezirkes Uster as a cooperative. Since 2012 the bank uses its current name.

In 2001 was opened a branch office in Dübendorf and in 2008 at Volketswil.

Services
The focus of BSU is on
 retail banking
 mortgage lending
 private banking
 banking for small and medium enterprises, etc.
It employs about 40 people and the balance sheet total was 977 million CHF in 2015.

Bank BSU is an independent regional bank of the RBA holding company.

References
Article contains translated text from Bank BSU on the German Wikipedia retrieved on 7 March 2017.

External links
Homepage in German

Banks of Switzerland
Banks established in 1836
Swiss companies established in 1836
Companies based in the canton of Zürich


text:
THE RATIONALE USE OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS) (ILORIN METROPOLIS AS A CASE STUDY)
Nonsteroidal anti-inflammatory drugs (NSAIDs) are medications used to relieve pain, fever and inflammation and they include a large group of anti-inflammatory agents that work by inhibiting the production of prostaglandins. Nonsteroidal anti-inflammatory drugs (NSAIDs) also represent diverse group of drug with analgesic property and most frequently prescribed drug globally. They represent the first choice of drug with well demonstrated efficiency for the pain management primarily musculoskeletal disorder and osteoarthritis to treat mild to moderate pain. Although its serious toxicity related to Gastro intestinal tract its choice in this category of its choice (Gul and Ayub, 2014).
There is overwhelming evidence linking chronic nonselective NSAID (including aspirin) use to a variety of Gastrointestinal (GI) tract injuries. Age is a significant risk factor for NSAID-induced GI events; indeed, patients above 75 years of age carry the highest risk and are similar in this respect to patients with a history of peptic ulcer (Beradi and Welage, 2005)
People desire to take responsibility for their own health care management. Many do so via self‑medication. Self‑medication is defined as the use of over‑the‑counter (OTC) drugs without consulting a professional health care practitioner. Self‑medication involves acquiring medication without a prescription, resubmitting an old prescription to procure medication, sharing medications with others, or utilizing a medication that is already available in the residence. Several governmental organizations developed policies to encourage self‑care for minor illnesses, reclassifying many drugs as nonprescription medications instead of prescription‑only medications, allowing the drugs to be administered by patients without a prescription. (Saeed et al, 2015) and could also be described as Medication that is taken on patient's own initiative or on advice of a pharmacist or lay person(Neha et al, 2013)
The terms 'misuse' and 'abuse' are often used interchangeably, but they have precise meanings in this context. Misuse is defined as using an OTC product for a legitimate medical reason but in higher doses or for a longer period than recommended. Abuse is the nonmedical use of OTC drugs(Gul and Ayub, 2015)
HISTORIC PERSPECTIVE OF NSAIDS
Aspirin and NSAIDs have a storied history in the treatment of pain and rheumatic diseases. In the 4th century B.C., Hippocrates detailed the use of powder made from the bark and leaves of the willow tree (Salixspp.) for headache, pain, and fever. Ancient Egyptians and Assyrians also used a willow extract to relieve the pain and erythema of inflamed joints( Apebum, 2002)
In 1828, Johann Buchner at the University of Munich extracted and purified salicin from willow, and three decades later, Charles Gerhardt succeeded in synthesizing a "buffered" form of salicylate to reduce dyspepsia, acetylsalicylic acid. This synthetic compound, containing no willow derivatives, was marketed by Felix Hoffmann of the Bayer company in 1899 as aspirin. The U.S. Food and Drug Administration (FDA) approved aspirin for the primary and secondary prevention of cardiovascular disease, and the secondary prevention of stroke and transient ischemic attacks, in 1988.
Additional NSAIDs were developed, such as phenylbutazone in 1949, indomethacin in 1963, and ibuprofen in 1969; however, the mechanism of action of these NSAIDs was unknown. In 1972, John R. Vane demonstrated that aspirin blocks the synthesis of a proinflammatory cytokine, prostaglandin E, for which he was granted the Nobel Prize in 1982 (Vane, 1971)
Prostaglandin synthase (COX), the enzyme inhibited by aspirin, which converts arachidonic acid to prostaglandins, was discovered in 1989, and was found to have two isoforms, COX-1 and COX-2; this discovery paved the way for the development of COX-2 selective inhibitors, which were hypothesized and later proven to have reduced GI toxicity.Babberdia,1999, Goldstain, 2001) .The first COX-2 selective inhibitor, celecoxib (Celebrex), approved by the FDA in 1998 based upon the results of five clinical trials involving more than 5000 patients with degenerative or rheumatoid arthritis, showed comparable analgesia and efficacy to nonselective NSAIDs and placebo with fewer clinical and endoscopic gastroduodenal ulcers.(Emery, 1999; silverstainn et al, 2000;Denson et al 1999; and Bonberdier et al 2000)
Two other COX-2 selective inhibitors, valdecoxib and rofecoxib, were subsequently approved; however, in the wake of concerns of an increased risk of thromboembolic events, and with valdecoxib an additional risk of Stevens–Johnson syndrome, both were withdrawn from the U.S. market in 2005(Bresalier et al, 2005; Solomon et al 2005). Celecoxib remains available for the treatment of pain associated with degenerative joint disease and rheumatoid arthritis, but as of April 2005 carries a "black box" warning alerting consumers to the increased cardiovascular risk associated with this medication.
Over the last few years, professional organizations, including the American College of Rheumatology, the American Pain Society (Emery et al 1999) , and the European League Against Rheumatism (Silverstein et al, 2000), have published treatment guidelines to assist clinicians in achieving effective pain management. Safety is a core concern in all these guidelines, especially for chronic conditions, such as OA, that require long-term treatment. Hence, there is a consensus among recommendations that paracetamol (acetaminophen) should be the first-line analgesic agent due to its favorable side effect and safety profile, despite several meta-analyses having shown that it is less effective in pain relief than anti-inflammatory drugs (Scarpignato et al, 2015).
Concerns have been raised regarding the safety of nonsteroidal antiinflammatory drugs (NSAIDs), which havebeen linked to increased cardiovascular morbidity. This association was first established in large clinical trials investigating the effect of selective cyclooxygenase-2 (COX-2) inhibitors on preventing gastrointestinal ulcers and gastrointestinal polyps. Later, these results have been confirmed in several large-scale observational studies(FitzGerald, 2003).
Pharmacists are usually the custodian of drugs and are charged with the responsibilities of delivering safe and efficacious medicines to the public (Owusu-Ansah, 2009) . In developing countries, traders perceive drugs as items of trade. In Nigeria, a country where the ratio of pharmacist to non-pharmacist in an urban environment and commercial centre, like Lagos is approximately 1:3, NSAIDs are sold or ingested without the required level of caution. These unregistered drug outlets, usually manned by traders, are located virtually in every street of urban centers in Nigeria.
Evaluation of drug use revealed that there was a great deal of drug misuse ranging from sub – therapeutic dosing, wrong indication and irrational combination of drugs, even in high doses (Awofisayo et al, 2008)
One of the conditions that necessitate the use of NSAIDs is pain. Pain is an unpleasant, subjective sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage.
Greater understanding of pain mechanisms and growing appreciation for pain control have, however, caused rheumatologists to consider new approaches in pain management.. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs). Both selective and nonselective cyclooxygenase (COX) inhibitors have antipyretic, anti-inflammatory and analgesic effects and are widely used in treating many painful conditions, including rheumatic diseases. NSAIDs are effective and widely available in over-the-counter formulations and in prescription products. Examples include ibuprofen, naproxen, diclofenac, and celecoxib. NSAIDs are frequently used without considering the relative contraindications since most NSAIDs are sold over the counter. Conventional NSAIDs are associated with gastrointestinal (GI) side effects. Estimates of the number of deaths from NSAID-related gastrointestinal bleeding vary widely and figures of approx. 3500 to 16.500 per year are quoted for the US in a recent FDA report. Both conventional NSAIDs and COX-2 inhibitors are associated with increased cardiovascular risk. NSAIDs may increase blood pressure, particularly in hypertensive patients. Of all NSAIDs, naproxen seems to pose the least cardiovascular risk, although naproxen is associated with the same risk for myocardial infarction as other NSAIDs. Contrary to some clinical assumptions, gastrointestinal risk is present at first dose with a non-selective NSAID, and co-therapy with a proton pump inhibitor (PPI) does not guarantee complete protection(Well et al, 2006)
Pain could be classified into two main groups: NOCICEPTIVE PAIN and NEUROPATHIC PAIN
THE NOCICEPTIVE PAIN
Nociceptive (acute) pain is either somatic (arising from skin, bone, joint, muscle, or connective tissue) or visceral (arising from internal organs such as the large intestine or pancreas).
Stimulation of free nerve endings known as nociceptors is the first step leading to the sensation of pain. These receptors are found in both somatic and visceral structures and are activated by mechanical, thermal, and chemical impulses. Release of bradykinins, K+, prostaglandins, histamine, leukotrienes, serotonin, and substance P may sensitize and/or activate nociceptors. Receptor activation leads to action potentials that are transmitted along afferent nerve fibers to the spinal cord.
Action potentials continue from the site of noxious stimuli to the dorsal horn of the spinal cord and then ascend to higher centers. The thalamus acts as a relay station and passes the impulses to central structures where pain is processed further.
The body modulates pain through several processes. The endogenous opiate system consists of neurotransmitters (e.g., enkephalins, dynorphins, and beta-endorphins) and receptors that are found throughout the central nervous system (CNS). Endogenous opioids bind to opioid receptors and inhibit the transmission of pain impulses.
The CNS also contains a descending system for control of pain transmission. This system originates in the brain and can inhibit synaptic pain transmission at the dorsal horn. Important neurotransmitters here include endogenous opioids, serotonin, norepinephrine, gama-aminobutyric acid (GABA), and neurotensin.
Neuropathic (chronic) pain is sustained by abnormal processing of sensory input by the peripheral or central nervous system. There are a large number of neuropathic pain syndromes that are often difficult to treat (e.g., low back pain, diabetic neuropathy, postherpetic neuralgia, cancer-related pain, spinal cord injury). Nerve damage or persistent stimulation may cause pain circuits to produce spontaneous nerve stimulation, autonomic neuronal pain stimulation, and a progressive increase in discharge of dorsal horn neurons.
The inflammatory process is the response to an injurious stimulus. It can be evoked by a wide variety of noxious agents (e.g., infections, antibodies, or physical injuries). The ability to mount an inflammatory response is essential for survival in the face of environmental pathogens and injury; in some situations and diseases, the inflammatory response may be exaggerated and sustained without apparent benefit and even with severe adverse consequences. No matter what the initiating stimulus, the classic inflammatory response includes calor (warmth), dolor (pain), rubor (redness), and tumor (swelling).
Inflammatory responses occur in three distinct temporal phases, each apparently mediated by different mechanisms:
(1) An acute phase characterized by transient local vasodilation and increased capillary permeability;
(2) A delayed, subacute phase characterized by infiltration of leukocytes and phagocytic cells; and
(3) A chronic proliferative phase, in which tissue degeneration and fibrosis occur.
Many mechanisms are involved in the promotion and resolution of the inflammatory process. Although earlier studies emphasized the promotion of migration of cells out of the microvasculature, recent work has focused on adhesive interactions, including the E-, P-, and L-selectins, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and leukocyte integrins, in the adhesion of leukocytes and platelets to endothelium at sites of inflammation.
Activated endothelial cells play a key role in "targeting" circulating cells to inflammatory sites. Expression of the adhesion molecules varies among cell types involved in the inflammatory response. Cell adhesion occurs by recognition of cell-surface glycoproteins and carbohydrates on circulating cells due to the augmented expression of adhesion molecules on resident cells. Thus, endothelial activation results in leukocyte adhesion as the leukocytes recognize newly expressed L-selectin and P-selectin; other important interactions include those of endothelial-expressed E-selectin with sialylated Lewis X and other glycoproteins on the leukocyte surface and endothelial ICAM-1 with leukocyte integrins. It has been proposed that some, but not all, NSAIDs may interfere with adhesion by inhibiting expression or activity of certain of these cell-adhesion molecules . Novel classes of antiinflammatory drugs directed against cell-adhesion molecules are under active development but have not yet entered the clinical arena.
In addition to the cell-adhesion molecules outlined above, the recruitment of inflammatory cells to sites of injury involves the concerted interactions of several types of soluble mediators. These include the complement factor C5a, platelet-activating factor, and the eicosanoid LTB4. All can act as chemotactic agonists. Several cytokines also play essential roles in orchestrating the inflammatory process, especially interleukin-1 (IL-1) and tumor necrosis factor (TNF) (Dempsey et al., 2003). IL-1 and TNF are considered principal mediators of the biological responses to bacterial lipopolysaccharide (LPS, also called endotoxin). They are secreted by monocytes and macrophages, adipocytes, and other cells. Working in concert with each other and various cytokines and growth factors (including IL-8 and granulocyte-macrophage colony-stimulating factor, they induce gene expression and protein synthesis in a variety of cells to mediate and promote inflammation.
IL-1 comprises two distinct polypeptides (IL-1a and IL-1b) that bind to the same cell-surface receptors and produce similar biological responses. Plasma IL-1 levels are increased in patients with active inflammation. IL-1 can bind to two types of receptors, an 80-kd IL-1 receptor type 1 and a 68-kd IL-1 receptor type 2, which are present on different cell types.
TNF, originally termed "cachectin" because of its ability to produce a wasting syndrome, is composed of two closely related proteins: mature TNF (TNF-a) and lymphotoxin (TNF-b), both of which are recognized by the same cell-surface receptors. There are two types of TNF receptors, a 75-kd type 1 receptor and a 55-kd type 2 receptor. IL-1 and TNF produce many of the same proinflammatory responses.
A naturally occurring IL-1 receptor antagonist (IL-1ra), competes with IL-1 for receptor binding, blocks IL-1 activity in vitro and in vivo, and in experimental animals can prevent death induced by administration of bacteria or LPS. IL-1ra often is found in high levels in patients with various infections or inflammatory conditions. Thus, the balance between IL-1 and IL-1ra may contribute to the extent of an inflammatory response. Preliminary studies suggest that the administration of IL-1ra (designated anakinra)¾by blocking IL-1 action on its receptor¾may be beneficial in rheumatoid arthritis and other inflammatory conditions(Louie et al., 2003; Olson and Stein, 2004).
Other cytokines and growth factors [e.g., IL-2, IL-6, IL-8, and granulocyte/macrophage colony stimulating factor (GM-CSF)] contribute to manifestations of the inflammatory response. The concentrations of many of these factors are increased in the synovia of patients with inflammatory arthritis. Certain relevant peptides, such as substance P, which promotes firing of pain fibers, also are elevated and act in concert with cytokines at the site of inflammation. Other cytokines and growth factors counter the effects and initiate resolution of inflammation. These include transforming growth factor-b1 (TGF-b1), which increases extracellular matrix formation and acts as an immunosuppressant, IL-10, which decreases cytokine and prostaglandin E2 formation by inhibiting monocytes, and interferon gamma, IFN-g, which possesses myelosuppressive activity and inhibits collagen synthesis and collagenase production by macrophages.
Histamine was one of the first identified mediators of the inflammatory process. Although several H1 histamine-receptor antagonists are available, they are useful only for the treatment of vascular events in the early transient phase of inflammation. Bradykinin and 5-hydroxytryptamine (serotonin, 5-HT) also may play a role in mediating inflammation, but their antagonists ameliorate only certain types of inflammatory response. Leukotriene (LT)-receptor antagonists (montelukast and zafirlukast) exert antiinflammatory actions and have been approved for the treatment of asthma. Another lipid autacoid, platelet-activating factor (PAF), has been implicated as an important mediator of inflammation; however, inhibitors of PAF synthesis and PAF-receptor antagonists have proven disappointing in the treatment of inflammation.
Intradermal, intravenous, or intra-arterial injections of small amounts of prostaglandins mimic many components of inflammation. Administration of prostaglandin E2 (PGE2) or prostacyclin (PGI2) causes erythema and an increase in local blood flow. Such effects may persist for up to 10 hours with PGE2 and include the capacity to counteract the vasoconstrictor effects of substances such as norepinephrine and angiotensin II, properties not generally shared by other inflammatory mediators. In contrast to their long-lasting effects on cutaneous vessels and superficial veins, prostaglandin-induced vasodilation in other vascular beds vanishes within a few minutes.
Although PGE1 and PGE2 (but not PGF2a) cause edema when injected into the hind paw of rats, it is not clear if they can increase vascular permeability in the postcapillary and collecting venules without the participation of other inflammatory mediators (e.g., bradykinin, histamine, and leukotriene C4 [LTC4]). Furthermore, PGE1 is not produced in significant quantities in humans in vivo, except under rare circumstances such as essential fatty acid deficiency. Unlike LTs, prostaglandins are unlikely to be involved in chemotactic responses, even though they may promote the migration of leukocytes into an inflamed area by increasing blood flow.
Rheumatoid Arthritis. Although the detailed pathogenesis of rheumatoid arthritis is largely unknown, it appears to be an autoimmune disease driven primarily by activated T cells, giving rise to T cell-derived cytokines, such as IL-1 and TNF-a. Activation of B cells and the humoral response also are evident, although most of the antibodies generated are IgGs of unknown specificity, apparently elicited by polyclonal activation of B cells rather than from a response to a specific antigen.
Many cytokines, including IL-1 and TNF-a, have been found in the rheumatoid synovium. Glucocorticoids interfere with the synthesis and actions of cytokines, such as IL-1 or TNF-a . Although some of the actions of these cytokines are accompanied by the release of prostaglandins and thromboxane A2 (TXA2), COX inhibitors appear to block only their pyrogenic effects. In addition, many of the actions of the prostaglandins are inhibitory to the immune response, including suppression of the function of helper T cells and B cells and inhibition of the production of IL-1. Thus, it has been suggested that COX-independent effects may contribute to the efficacy of NSAIDs in this setting. Besides an impact on adhesive interactions, salicylate and certain NSAIDs can directly inhibit the activation and function of neutrophils, perhaps by blockade of integrin-mediated neutrophil responses by inhibiting downstream Erk signaling.
The availability of a wide variety of drugs coupled with easy access and lack of effective regulatory control has led to problems associated with drug use like self-medication, drug misuse and drug abuse (Amoako et al 2003). Self medication: defined as the act of taking medicines or medical devices especially designed and labeled for use in the treatment of common health problems without the authority or prescription of a physician (Lawan et al, 2013). Drug abuse is the recurrent use of illegal drugs, or the misuse of prescription or over-the-counter drugs with negative consequences. Hence, drug misuse is an aspect of drug abuse. This practice cuts across all age groups, gender, educational backgrounds, marital status, employment and occupation. Pattern of drug misuse varies from place to place and it is known to be affected by socio-economic factors (Kehinde and Ogunnowo, 2013).
Self-medication is the act of taking medicines or medical devices especially designed and labeled for use in the treatment of common health problems without the authority or prescription of a physician and it is one of the rapidly growing areas of concern to medical professionals, government and the general public (Lawan et al, 2013).
There is overwhelming evidence linking chronic nonselective NSAID (including aspirin) use to a variety of Gastrointestinal (GI) tract injuries. Age is a significant risk factor for NSAID-induced GI events; indeed, patients above 75 years of age carry the highest risk and are similar in this respect to patients with a history of peptic ulcer (Berardi and Welage, 2005).
NSAIDs rank second to aminoglycosides as the most common cause of drug induced renal failure (ARF) and also known to cause acute interstitial nephritis with haematuria, proteinuria and flank pain (Welton, 1999).
In a study carried out in Ghana, about 40% of prescribed analgesics were NSAIDs and diclofenac was the most widely prescribed (Owusu-Ansah, 2009).
Aspirin remains the most commonly prescribed NSAIDs in cardiovascular diseases like hypertension and ischemic heart disease where it is used as antiplatelet agent(Aguw and Adibe, 2012).
Exposure of pregnant women to any type of NSAIDs during early pregnancy predispose them to spontaneous abortion (Li et al, 2003)
A high proportion of chronic urticarial patients experience symptom aggravation when exposed to aspirin and NSAIDs known as Aspirin-exacerbated cutaneous disease (Sánchez-Borges, 2013)
MECHANISM OF ACTION OF NSAIDs
Salicylic acid and salicylates, obtained from natural sources, have long been used as medicaments. Salicylic acid was chemically synthesized in 1860 and was used as an antiseptic, an antipyretic, and an antirheumatic. Almost 40 years later, aspirin was developed as a more palatable form of salicylate. Soon after, other drugs having similar actions to aspirin were discovered, and the group was termed the "aspirin-like drugs" (also now termed the nonsteroidal anti-inflammatory drugs [NSAIDs]). Twenty-five years ago, it was proposed that the mechanism of action of NSAIDs was through their inhibition of prostaglandin biosynthesis. Since then, there has been general acceptance of the concept that these drugs work by inhibition of the enzyme cyclo-oxygenase (COX), which we now know to have at least two distinct isoforms: the constitutive isoform, COX-1, and the inducible isoform, COX-2. COX-1 has clear physiologic functions. Its activation leads, for instance, to the production of prostacyclin, which when released by the endothelium is antithrombogenic and when released by the gastric mucosa is cytoprotective. COX-2, discovered 6 years ago, is induced by inflammatory stimuli and cytokines in migratory and other cells. It is therefore attractive to suggest that the anti-inflammatory actions of NSAIDs are due to inhibition of COX-2, whereas the unwanted side-effects, such as irritation of the stomach lining, are due to inhibition of COX-1. Drugs that have the highest COX-2 activity and a more favorable COX-2: COX-1 activity ratio will have a potent anti-inflammatory activity with fewer side-effects than drugs with a less favorable COX-2.(Vane and Botting, 1998)
All NSAIDs, including the subclass of selective COX-2 inhibitors, are antiinflammatory, analgesic, and antipyretic. NSAIDs are a chemically heterogeneous group of compounds, often chemically unrelated (although most of them are organic acids), which nevertheless share certain therapeutic actions and adverse effects. Aspirin also inhibits the COX enzymes but in a manner molecularly distinct from the competitive, reversible, active site inhibitors and is often distinguished from the NSAIDs (Brunton et al, 2008).
Aspirin covalently modifies COX-1 and COX-2, irreversibly inhibiting cyclooxygenase activity. This is an important distinction from all the NSAIDs because the duration of aspirin's effects is related to the turnover rate of cyclooxygenases in different target tissues. The duration of effect of nonaspirin NSAIDs, which competitively inhibit the active sites of the COX enzymes, relates more directly to the time course of drug disposition. The importance of enzyme turnover in relief from aspirin action is most notable in platelets, which, being anucleate, have a markedly limited capacity for protein synthesis. Thus, the consequences of inhibition of platelet COX-1 (COX-2 is expressed only in megakaryocytes) last for the lifetime of the platelet. Inhibition of platelet COX-1-dependent TXA2 formation therefore is cumulative with repeated doses of aspirin (at least as low as 30 mg/day) and takes roughly 8 to 12 days¾the platelet turnover time to recover once therapy has been stopped(Brunton et al, 2008).
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Dow Chemical chooses Jacobs to design expansion
PASADENA, Calif. (July 3) — Dow Chemical Co. has hired Jacobs Engineering Group Inc. to design the announced expansion to the firm's solution elastomer plant in Schkopau, Germany.
The project involves adding a third process train to the existing production facility. Jacobs said it will perform detailed engineering for the process unit's portion and managing the offsite interfaces.
The firm will do the detailed engineering entirely from its office in Mumbai, India, with management from its hydrocarbon center in Leiden, Netherlands. The project is scheduled for completion in 2008.
The companies didn't disclose the value of the contract.


Blood-Filled Spit on the Ore-Rich Ground. Country Music is a collaborative project, digital label and publishing platform by Daniel Iinatti and Anna Sagström dedicated to a reimagined club music of the land and the contemporary periphery through explorations in music and tempo with producers from all over all counties. Releasing music, hosting parties and distributing text, Country Music is an alloy of work, speed and materials for a duration of 8 minutes, 4 pages or an entire evening at a time.
Stamping on the metals of the festival site, Country Music presents a program with live performances by Oxhy, HAJ300 and Via App together with DJ sets by Gil, Iinatti and Why Be, together with a text performance.


Los Angeles (AFP) - Los Angeles Angels general manager Billy Eppler on Monday denied a report that two-way star Shohei Ohtani faced season-ending Tommy John surgery on his damaged elbow.
ESPN baseball commentator Pedro Gomez reported on Sunday that Ohtani was expected to undergo surgery on his elbow that could leave him sidelined until 2020.
However Angels GM Eppler swiftly played down the reports early Monday, telling the MLB Network that there had been no change in Ohtani's condition.
The Japanese star is currently out for three weeks after suffering sprained elbow ligaments, and the club is hopeful he may respond to platelet-rich plasma and stem cell therapy.
"There have been no changes in Ohtani's diagnosis and neither our physicians nor medical staff have recommended (Tommy John surgery) or said it's likely," Eppler said.
The Angels announced on Friday that Ohtani has a grade 2 sprain of the ulnar collateral ligament in his right elbow.
Ohtani's injury is a blow to the Angels, who are 37-29 as they attempt to stay in touch with the pace-setting Seattle Mariners and Houston Astros in the American League West division.
Pitchers suffering elbow injuries involving the UCL often require Tommy John surgery to repair the problem, leading to a lengthy rehabilitation.
Los Angeles Dodgers shortstop Corey Seager was ruled out for the entire season in April after undergoing surgery to repair damaged ligaments in his right elbow.


text:
Denial of Tenure Defended [on Norman Finkelstein]
FINKELSTEIN | DePaul chief upholds faculty panel's decision on controversial prof
by Dave Newbart
https://www.meforum.org/campus-watch/11793/denial-of-tenure-defended-on-norman-finkelstein
In his first interview since controversial Professor Norman Finkelstein was denied tenure in June, DePaul University President Dennis Holtschneider said Friday he was compelled to uphold the decision of a faculty committee that reviewed the case.
The seven members of the University Board on Promotion and Tenure -- which voted 4-3 against granting Finkelstein tenure in the political science department -- "were accused of being diverted or pressured by outside groups," Holtschneider said. "But as I read through everything they had done, it just wasn't the case. Faculty here come at it very independently. So I just thought, I have to support these folks. They made a very hard decision, and they've done it with great integrity, and it deserves to be approved."
Holtschneider said he wasn't surprised that students continue to protest the decision after summer break.
"You never really know, and the students were certainly saying they were still concerned," he said. "The students told us they were going to be here today, and that's their right."
Holtschneider made his brief remarks to a reporter after DePaul's convocation Friday kicking off the upcoming school year. DePaul Provost Helmut Epp also spoke of the "conspiracy theories" about Finkelstein's denial but emphasized that the faculty ultimately made the decision.
Earlier, as violin music played and a choir sang, nearly 300 faculty dressed in black robes and colorful regalia marched down tree-lined streets on DePaul's Lincoln Park campus. But marching alongside them were 30 protesters, wearing T-shirts saying, "We are all Professor Finkelstein." They later set up inside the convocation at St. Vincent de Paul Catholic Church and held protest signs near university banners. More than a dozen faculty also donned the pro-Finkelstein T-shirts under their robes.
Philosophy Professor Tina Chanter said she thinks Finkelstein's tenure was denied because of his pro-Palestinian writings and his views that some Holocaust survivors had exploited their suffering.
She said it was "absolutely outrageous" that Finkelstein was put on paid administrative leave and would not be allowed to teach a final year, as is standard when a professor is denied tenure. She said procedural violations took place in denying Finkelstein tenure.
Holtschneider said proper procedures were followed.
"This process was clean," he said. "The faculty took this very, very seriously."
Sources familiar with the situation said Finkelstein's supporters first sought the paid leave when he indicated earlier in the summer that he didn't want to return. But when he decided he wanted to come back, the university cited alleged confrontations between Finkelstein and an administrator and some faculty members who opposed his tenure bid as reasons not to allow him back.
Spokeswoman Denise Mattson would not say why Finkelstein was not allowed back. Finkelstein, who was not at the convocation, could not be reached for comment. His supporters say he plans to teach his canceled class in the public library near campus next Wednesday and then plans to try to enter his old office.
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and dressing them creatively in themed groups that have attracted visitors to the town for as many years.
Come and see more than 250 handmade scarecrows artfully placed throughout the town .
Find your old favourites and experience new creations!
Visit us on facebook to watch behind the scenes scarecrow creation!
Host Jon Montgomery agreed that Mahone Bay was Canada's loveliest little town as he and Festival Chair and Judge for Episode 8, Lara Carrigan watched the competitors start to arrive. Jet arrived first and hastily chose to compete in the Road Block, which required each team to use a BlackBerry Z10 with a photo of a hidden Scarecrow somewhere in town. To make matters more challenging the contestants had to run through the streets find the scarecrow pictured on their Blackberry and bring them back to the Gazebo on Main St. where they would build an exact replica of the scarecrow. Viewers laughed as the contestants sorted through piles and piles of clothing, straw, stuffing and props in order to create their new twin scarecrows. Jet soon lost his lead to Cory, and then Tim Jr., when he could not recreate his voluptuous gypsy woman. He joked and said, "Scarecrows: how many have I built? Zero. How many women have I helped get ready for a Saturday night? Different equation."
All of the scarecrows created by the contestants are on display during the festival.


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Stan Eakin with his 1929 Pontiac Big Six coupe. "It chugs along. I'm pretty happy with it
HOT CAR: 1929 Pontiac Big Six
Stan Eakin kept the 1929 vehicle pretty much stock, right up to the wooden roof that he rebuilt himself.
Octavian Lacatusu
Aug. 11, 2016 5:00 a.m.
As we idle in our econoboxes, surrounded by crash barriers, air bags, air conditioning and power steering, it's hard to see what we take for granted when it comes to driving.
To get an idea of just how spoiled we are with standard automotive options today, we took a look at Sooke resident Stan Eakin's 1929 Pontiac Big Six coupe, a car he'd bought in boxed pieces for $6,000 nearly 20 years ago.
"A friend of mine asked me, do you want to restore an old car? I said, heck, everybody wants to restore an old car!'" Eakin laughed.
Eakin made the Pontiac his personal project: redoing the frame and rebuilding the car from the ground up to the same specs it had when it rolled off the assembly line from General Motors' plant in Oakland, Calif. more than 80 years ago.
He recalls the day when he got the car back home.
"I brought it home and said to my neighbour, 'I'll get it and work on it, but you have to come up and help me if I run into any trouble'," Eakin said.
Unlike other restorations, where modern components are added such as interior comforts and more powerful and reliable powertrains, Eakin kept his 1929 pretty much stock, right up to the wooden roof that he rebuilt himself.
The same continues under the car's folding hood, which contains Pontiac's "Big Six" 6-29 Series, a 3.3-litre (200 cubic-inch) flathead straight-six cylinder engine capable of a modest 60 horsepower.
Putting the power down is also from the era, a three-speed manual transmission with reverse gear. Keep in mind this is pre-synchromesh gears, unlike in modern manual gearboxes, meaning you'd have to be telepathic to know when to shift without grinding each gear into metal filings.
Still, the Pontiac Big Six was far from crude.
It came standard with a starter motor at a time when prospective car owners had their wrists broken by manual handcranking their engines. It was also smart and simple, bearing an odometer, horn, light switch (from very dull to very bright) and a clever "air conditioning" system that funneled cold air from under the car and into the cabin.
And the signal lights?
"There are none, you just had this," Eakin laughed, stretching out his arm as if signaling a left. Yup, you'd signal like a cyclist, as signal lights were neither mandatory or available in those days. Or seatbelts, for that matter.
Despite its flaws though, Eakin is pleased with the car.
"It chugs along, I'm pretty happy with it," he said.
The Pontiac is not Eakin's only toy. He plans to sell it and make way for his next project, a DeSoto sedan of the same era.
Fishers hook into large salmon
Fish biting well in Sooke waters


text:
HomeNewsDestrehanHealthy choices pay off for local woman
Healthy choices pay off for local woman
April 16, 2021 Monique Roth Destrehan, Featured, Health, Lifestyles, Profiles, St. Charles Parish
Kim Costandi said she is currently working out four to five days a week, and that her overall health has become her main goal.
Destrehan resident Kim Costandi was athletic and involved in sports year-round when she was growing up, but adult responsibilities and motherhood meant she had a hard time incorporating exercise into her weekly routine.
That is, until February of 2020.
"Exercise was not really my thing," she said. "I did do a bit of martial arts for a few years and managed to get to the rank of Decided 1st Degree Black Belt in Taekwondo, but that was about it."
Costandi first joined Anytime Fitness Destrehan in 2013 but had stopped going for years. She rejoined in February 2020.
"I hate that I got off track, but I'm not planning on going anywhere again," she said. "My goals when I rejoined were to start making time for me again and commit to getting back in shape. I've worked from home the last two and a half years and it hasn't been easy to stay active during the day. I also want to get healthy for my son – not only to set a good example, but to make sure I'm around to watch him grow up and have his own babies."
When Costandi rejoined the gym on Feb. 24, 2020, she became a participant of the center's FitFest and started small team training as a way to jumpstart being back at in the gym. Little did she know gyms would close due to the coronavirus pandemic just a few weeks after she rejoined.
"I think we all faced the same obstacle this year," she said. "The gym closing in March was a huge stumbling block. It would have been easy to settle into old ways, especially with virtual schooling and work occupying the day, but with the beautiful weather through most of the closure, bike rides and walks with the dog became daily rituals we all looked forward to."
Costandi said when Memorial Day 2020 rolled around and the gym offered an outdoor workout, she was so happy to be back in a fitness training atmosphere.
"I was excited to start working towards my 100 workout goal," she said. "It was great to get back in a more scheduled routine."
Costandi said she is currently working out four to five days a week, and that her overall health has become her main goal.
"For anyone just getting started or needing a little help or a reset, the best advice I can give is to keep going," she said. "I just want to be healthy. I'm in a good spot right now, but it's a never-ending journey."
St. Charles Parish Louisiana
Chance meeting leads to unique Life Skills program
Free Concert in the Park slated for Sunday
January 19, 2022 Ryan Arena Boys Basketball, Featured
In year one under head coach Troy Green, Destrehan learned his way of doing things on the basketball court. In year two, the Wildcats have made a leap. As Destrehan (18-4) prepares for a key […]
Quartet delivers familiar sound in a different package, in Luling for concert
January 13, 2022 Ryan Arena News
"Where Bach meets Bon Jovi" may seem like an odd fit, but for violist Ian Zanca and his fellow Dallas String Quartet musicians – and the millions who have enjoyed their performances – it strikes just the right note. […]
Sheriff's Report 1-6-2022
January 6, 2022 heraldguide Crime, Sheriffs Reports
Suspects are innocent until proved guilty in a court of law. Arrests • Adrian Hotard, 51, of 219 Bridge Road in Des Allemands, was arrested Dec. 17 and charged with domestic abuse battery with strangulation. […]
About Monique Roth	559 Articles
Roth has both her undergraduate and graduate degree in journalism, which she has utilized in the past as an instructor at Southeastern Louisiana University and a reporter at various newspapers and online publications. She grew up in LaPlace, where she currently resides with her husband and three daughters.


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Pippen III oþþe ōþre naman Pepin Scorta (fram þǣm 714. gēare ōþ þæt 768. gēar) ƿæs Francena Cyning fram þǣm 751. gēare ōþ þæt 768. and hē ƿæs se ǣrrsta Francena cyning þæs Carles hūses. His sunu and æftergenga ƿæs Carl Micela Francena Cyning, and his cynecynn is æfter þissum Carle genemned.
Man nīwanost wende þisne tramet on þǣre 03:53 tīde þæs 10 Þrimilcemōnaþ 2018.


This paper craft is a simple Origami Stellated Octahedron / Inflatable Star, created by Chrissy Pk.
I love this origami ornament, a lot of modular models that look similar to this one, take ages to make, this one is finished in a few minutes. It would look awesome as a Christmas star, or tree decoration!


In spite of the disparate uses, I would offer that the reading should be rip, rip.
When you eat potato chips, your teeth are ripping the chips apart; they are too brittle to resist even the incisors and canines.
When something is being scratched, a fraction of the surface is being ripped off.
When you rip something, it makes this discordant noise.
When electricity rips through the air, it crackles.
In all cases, バリバリ (baribari) describes a ripping sound while an object is being ripped (that is, is stripped of its cohesion).
In a somewhat more figurative sense, バリバリ (baribari) can be used to represent letting rip with an electric guitar while rocking and rolling.
This entry was posted in Onomatopoeia and tagged Japanese, Manga, Sound Effects. Bookmark the permalink.
Thanks i had no idea how to translate that onomatopoeia!