By accepting the Purchase Order ("PO"), Seller agrees to the following terms and conditions ("T&Cs"). Seller's acceptance of the PO shall be conclusively affirmed by any one of the following: (a) Seller's acknowledgment of the PO; (b) Seller's shipment of Goods; (c) Seller's performance of services; or (d) Seller's acceptance of payment. "Goods" is defined as the materials, products or services to be purchased or to be supplied as set forth in the PO. "Seller" is defined as the party supplying Goods to SI-BONE.
The PO and these T&Cs constitute the entire agreement of the parties with respect to the purchase of the Goods. Conflicting, differing or additional terms contained in any other document (including but not limited to agreements, quotations, order acceptances, confirmations, or invoices) are hereby rejected and shall have no effect unless expressly agreed to in a writing signed by an authorized SI-BONE representative.
Title and all risk of loss shall remain with the Seller until the Goods are delivered to the location designated by SI-BONE. Passing of title and risk of loss shall not affect SI-BONE's right to reject the Goods.
Unless otherwise stated in the PO, SI-BONE will pay Seller within 45 days of the date of delivery, the date of acceptance, or the date SI-BONE received an invoice, whichever is later. Seller will pay all freight, insurance and other shipping expenses and all sales, use and other applicable taxes, duties and similar charges that are assessed against the Goods.
Time is of the essence. Failure to deliver on the date specified in the PO shall be considered a material breach and shall entitle SI-BONE to any or all of the following: (a) cancel the order without penalty to SI-BONE; (b) refuse to accept any subsequent delivery of the Goods; (c) recover from Seller any and all costs reasonably incurred by SI-BONE in obtaining substitute Goods from another source, including but not limited to the difference in the price of the Goods; and/or (d) recover from Seller any and all pre-payments and any and all damages relating to Seller's failure to deliver the Goods on time. Whenever any event delays or threatens to delay timely performance, Seller will immediately notify SI-BONE in writing and furnish all relevant details. Such notice will not constitute a waiver of Seller's delivery time obligations.
Within a reasonable time of delivery and inspection, SI-BONE shall have the right to reject Goods delivered by Seller that do not meet with SI-BONE's approval, including but not limited to those Goods that are not of the quality, not in the quantity, or that are unfit for the purpose for which SI-BONE requires them or fail to conform to any specifications provided by SI-BONE. Seller shall not deviate from any specifications or requirements provided by SI-BONE and Seller agrees to notify SI- BONE in advance of any changes, alterations, deviations or modifications to any Goods, provided, however, that such notification, even if provided prior to delivery of any Goods, shall not limit any rights or remedies of SI-BONE under these T&Cs and applicable law, including the right to reject any non-conforming Goods. In such case and without any waiver of any other right SI-BONE may have, SI-BONE shall have the right to recover from Seller (a) any and all pre-payments, (b) any and all costs reasonably incurred in obtaining substitute Goods from another seller, including but not limited to the difference in the price of the goods, and (c) any and all damages relating to Seller's failure to deliver acceptable Goods. The making of any prior payments shall not prejudice SI-BONE's right to reject. SI-BONE may, at its sole discretion, reject any partial shipment. Acceptance by SI-BONE of any partial shipment of an order will not constitute SI-BONE's acceptance of the entire order, absent SI-BONE's written acceptance of such entire order. Rejected Goods and Goods that may be supplied in excess of any quantities ordered herein will be held at Seller's sole risk and expense, and such Goods may be returned to Seller at Seller's sole expense. In addition to SI-BONE's other rights, SI-BONE may charge Seller, and Seller shall pay promptly, all expenses of unpacking, examining, re-packing and re-shipping any such Goods. In the event of the performance of any services or the delivery of any Goods that contain any defect or nonconformity that is not apparent upon examination, all of the remedies provided for hereunder shall be available to SI- BONE. Nothing contained in the PO or these T&Cs shall relieve the Seller in any way from its obligation of testing, inspection, and quality control in full accordance with all industry standards applicable to all Goods and services ordered hereunder.
At any time prior to acceptance, SI-BONE may cancel or reschedule all or part of an order for any or no reason upon written notice to Seller. Seller shall cease work in progress on cancelled orders immediately upon receiving a cancellation notice. In the event of cancellation by SI-BONE for cause, SI-BONE shall not be liable to Seller for any amount, and Seller shall be liable to SI- BONE for any and all damages sustained by reason of the default or failure that gave rise to the cancellation. In the case of cancellations by SI-BONE without cause, SI- BONE shall make reasonable payment for the following: (a) work completed, at full unit price; (b) work in progress, at reasonable cost of completed operations on notice date; and (c) raw materials and purchased parts, at cost to Seller. Any partial or completed work or materials that are paid for by SI-BONE shall, at SI-BONE's option, become the property of SI-BONE. To mitigate SI-BONE's costs under such circumstances, at the request of SI-BONE, Seller shall use reasonable efforts to sell completed Goods, raw materials and purchased parts to other parties, and any payments received as a result shall be offset against and reduce the amount owed by SI-BONE.
Unless otherwise specified, Seller will pack all goods in accordance with good commercial practice and insure safe arrival of goods at SI-BONE. An itemized packing list specifying the shipment contents and the PO Number (PO#) must accompany each shipment.
Seller acknowledges that the PO, T&Cs, and all supporting documentation, including but not limited to the identity of the items, design, specifications, price and quantity, are considered SI-BONE's confidential and propriety information. Seller agrees to keep this information strictly confidential and not use or disclose it at any time.
Seller warrants that all Goods will (a) be new and free from defects in workmanship, material, and manufacture, (b) comply with the requirements of the PO, including any drawings or specifications incorporated herein or samples furnished by Seller, (c) where design is not SI-BONE's responsibility, be free from defects in design, (d) be of merchantable quality and be fit for the purpose intended by SI-BONE, (e) be appropriately contained, packaged, marked, and labeled; and (f) be manufactured by Seller or procured by Seller directly from either the manufacturer or the manufacturer's distributor of record. Seller further warrants that all Goods furnished hereunder (i) will be safe and appropriate for the purpose or purposes for which such Goods of that kind are normally used, and (ii) will be free from any liens, encumbrances or claim of any third party, including any claims of infringement or violation of any patents, copyrights, trade secrets, licenses or other property rights of any third party. The foregoing warranties are in addition to all other warranties, whether expressed or implied, and shall survive any delivery, inspection, acceptance or payment by SI-BONE. All warranties run to the benefit of SI-BONE and its customers. SI-BONE's approval of Seller's material or design, or changes thereof, will not relieve Seller of any warranties. In addition, Goods furnished hereunder will be subject to all written and oral express warranties made by Seller's agents, and to all warranties provided for by the California Commercial Code.
No right or obligation, including the right to receive payments due, may be assigned by Seller without the prior written consent of SI-BONE, and any purported assignment without such consent will be void. SI-BONE may assign its rights at any time.
Advertising. Seller shall not use SI-BONE's name or refer to SI-BONE directly or indirectly in any advertisement or presentation, sales literature, list of Seller's clients, or news release, or release to any publication without SI-BONE's prior written approval.
Seller (the "Indemnifying Party") agrees to indemnify and hold SI-BONE and its affiliates, officers, directors, agents and employees ("Indemnitees") harmless from and against all actions, liabilities, losses, damages, claims and demands whatsoever, including, but not limited to, attorney fees and other expenses ("Claims") that are brought or threatened against the Indemnitees that are related to the Indemnifying Party's (a) violation of any law or regulation, (b) breach of any term or condition of the PO or these T&Cs, or (c) negligence, recklessness or willful misconduct. The duty to indemnify will not apply to the extent that any Claim arises from the negligence, recklessness, or willful misconduct of an Indemnitee. Seller further agrees to indemnify and hold Indemnitees harmless for any and all Claims alleging that the Goods infringe, misappropriate or violate any United States or international patent, copyright, trade secret or any other third party proprietary or intellectual property right. SI-BONE agrees that Seller has the right to defend, or at its option to settle any such Claim, and Seller agrees, at its own expense to defend, or at its option to settle any such Claim, suit or proceeding brought against SI-BONE on the issue of such infringement, misappropriation or violation of any trade secret or other proprietary right, provided that SI-BONE shall retain the right to procure its own additional counsel, at SI-BONE's expense, to advise SI-BONE and further defend its interests and that no settlement shall occur without SI-BONE's written consent. SI- BONE shall notify Seller promptly of any such claim and shall reasonably cooperate with Seller at Seller's expense in the defense thereof.
IN NO EVENT SHALL SI-BONE BE LIABLE TO SELLER FOR SPECIAL, INCIDENTAL, CONSEQUENTIAL, OR INDIRECT DAMAGES ARISING FROM OR RELATING TO THIS AGREEMENT (WHETHER IN CONTRACT, TORT, NEGLIGENCE, STRICT LIABILITY, BY STATUTE OR OTHERWISE). THESE LIMITATIONS SHALL APPLY EVEN IF SUCH PARTY HAS BEEN ADVISED OR IS AWARE OF THE POSSIBILITY OF SUCH DAMAGES.
Seller represents and warrants that Seller has insurance in amounts of not less than $1,000,000 per occurrence and $3,000,000 in the aggregate for workers' compensation, comprehensive general liability, professional services liability and products liability coverage insuring Seller's liability and that of Seller's employees, agents and subcontractors arising out of and in connection with providing the Goods.
Seller warrants that it will comply at Seller's own expense with all applicable federal, state, and local laws and regulations and industry guidelines. Seller represents and warrants that it has in effect all licenses, permits and government authorizations necessary to provide the Goods.
If any provision of these T&Cs is declared invalid, illegal, or unenforceable, such provision will be severed and all remaining provisions will continue in full force and effect. No failure or delay to exercise any right, power or privilege hereunder will operate as a waiver thereof, and no single or partial exercise thereof will preclude any other or further exercise thereof or the exercise of any right, power or privilege hereunder. These T&Cs will be governed by and constructed in accordance with the laws of the State of California without regard to the conflicts of the law principles thereof. The rights and obligations of the parties which by their nature survive termination or completion of the PO and/or these T&Cs, include, but are not limited to, those set forth herein in the paragraphs entitled "Warranty," "Advertising," "Liability Limitation," "Indemnification," and "Confidentiality," which shall remain in full force and effect.


text:
Rakitha Malewana is a Sri Lankan young scientist and youth activist. He was awarded the Nalanda Puthra award in 2015 from his alma mater Nalanda College, Colombo and received a presidential medal for innovation and social work from the government of Democratic Socialist Republic of Sri Lanka. In 2016, he was awarded the prestigious Queen's Young Leaders Award by the Royal Commonwealth Society as an honor to his social work on behalf of the HIV positive community. He is one of the youngest honorees of Forbes 30 under 30 Asia 2017.

Achievements

Malewana does his medical research in collaboration with University of Colombo, Medical Research Institute Sri Lanka, National Science Foundation of Sri Lanka, Ministry of Health and Government Analyst's Department Sri Lanka.

He won a gold medal at the International Science Research Olympiad 2015 held in Jakarta, Indonesia in year 2015  and the same year he won another gold medal at the International Environment Sustainability Olympiad 2015, held in The Netherlands becoming the first Sri Lankan to win an Olympiad gold medal at an international competition.

His research on development of novel drug to kill leukemic cells won a bronze medal at the International Science Projects Olympiad 2014 held in Jakarta, Indonesia selected to represent Sri Lanka at the Intel International Science and Engineering Fair (Intel ISEF) which is one of the most prestigious science and engineering events in the world calendar for high school students.

In 2013, he became the national winner of Sri Lanka Science and Engineering Fair (SLSEF) for the second consecutive year for his preliminary study on developing an ayurvedic drug to treat thrombocytopenia and he represented his work at the Intel ISEF 2013 held in Arizona, USA.

Activism

Malewana first started working with HIV/AIDS positive people in 2011 when he visited slum areas to teach sciences to the children of people living with HIV. In 2012, he founded ideanerd Sri Lanka, which encourages school children to get involved in science research and promote an innovation culture. So far, it has helped more than 50,000 students all over the country. In 2015, Rakitha co-founded United Youth Consortium to raise awareness of sexual and reproductive health issues and provide support and counseling to families living with HIV. His movements include fighting with the government to bring justice to HIV positive children who were banned to attend local schools. He is also an advocate for health disparities in developing countries. Malewana collaborate his social work with National STD/AIDS Control Programme Sri Lanka and UNAIDS Sri Lanka.

For his grassroot activism, he was awarded the prestigious Queen's Young Leaders Award in 2016. The Queen's Young Leaders Award is designed to inspire and nurture the talent of exceptional young people from all over the Commonwealth and they can create and lead others towards securing positive changes in communities. The award was presented by her majesty the queen Elizabeth II at the Buckingham Palace.

References

External links
 Sri Lanka fielded three young scientists to participate Intel International Science and Engineering Fair 2014
 President felicitates Sri Lankan students participated in Intel Science and Engineering Fair
 President felicitates winners of Intel ISEF 2014
 Nalanda Student Finds A Remedy For Leukemia From Green Tea
 Nalanda College student invented a cure for AIDS
  International Environment & Sustainability Project Olympiad
 Gifted with a flair for science and doing country proud
 ලංකාවේ සිසුවකු ඒඩ්ස්වලට ඔෟෂධයක් හදලා උපහාර දක්වන්න බි්‍රතාන්‍ය අගමැතිගෙන් ලන්ඩනයට කැඳවීමක්
 ඒඩ්ස් වෙනුවෙන් ඖෂධයක් නිපදවු නාලන්ද සිසුවාට බ්‍රිතාන්‍ය අගමැතිගෙන් ආරාධනා
 නෙත් එෆ්.එම් කලබල පැංචා ඒඩ්ස් වලට ඖෂධයක් සොයාගනී!
 කැමරන්ගෙන් ආරාධනා ලත් ලාංකික සිසුවාට තවත් රන් පදක්කමක්
 THE ARTY SMARTY PRODIGY

Sri Lankan Buddhists
Sri Lankan scientists
Alumni of Nalanda College, Colombo
Sinhalese activists
Living people
Year of birth missing (living people)

redpajama_set_name: RedPajamaWikipedia


The Bay Area Council Committee on Water & Climate Resilience brings together the region's largest employers and water agencies to provide policy guidance and perspective on issues involving climate resilience, including water supply reliability, extreme storm events, and sea level rise.
The California Resilience Challenge is a statewide effort, led by businesses and a diverse range of partners, to build local climate resilience and support a shared vision for a resilient California in the face of increasing climate threats. The Challenge is seeking submissions for diverse and replicable climate change resilience projects from across California. The projects will reflect California's diverse geography and showcase leadership in climate change adaptation, with a focus on increasing resilience to droughts, floods, extreme heat, and wildfires. Visit the California Resilience Challenge website.
Following years of advocacy by the Bay Area Council and its partners, the US Army Corps of Engineers announced it would provide full funding for the South Bay Shoreline project. The $177 million project includes the construction of four miles of new levees along the Santa Clara County shoreline, and the restoration of 3,000 acres of wetland habitat, making it the largest wetland restoration project outside of the Florida Everglades. According to a 2015 report from the Bay Area Council Economic Institute, Santa Clara County is the region's most economically vulnerable county to extreme-storm related flooding.
The California Commission approved $485 million in voter-approved bond funding for the Santa Clara Valley Water District's Pacheco Reservoir Project, a new 319-foot-tall dam Santa Clara County, and $459 million for the Contra Costa Water District to raise Los Vaqueros reservoir by 55 feet. Combined, the two projects would add a total of 255,000 acre-feet of new water for Bay Area residents and businesses. An acre-foot is roughly equal to the amount of water an average household uses in one year. The Sites Reservoir, another project the Council supported, received $816 million. The Council's Water Committee had identified all three projects as top priority for regional water security.
Over 5 million Californians get their drinking water from investor-owned water utilities regulated by the California Public Utilities Commission (CPUC). Those utilities rely on private investment to maintain their systems. In exchange, the utilities provide investors a return on their money. The CPUC decides the rate of return, and last month proposed lowering the rate of return that private water utilities could provide to the lowest level in the nation. That could have dried up this important source of investment and jeopardized their ability to ensure the health, safety, and reliability of their systems. The Bay Area Council stepped in, assembled a coalition of other regional business groups, and in public testimony urged the CPUC to make sure California's investor-owned water utilities remained nationally competitive. On Thursday (March 22), the CPUC unanimously voted to maintain a competitive rate of return that allow utilities to raise the capital they need to keep investing.
SB 231 (Hertzberg) amends the Proposition 218 Omnibus Implementation Act to clarify that stormwater management is a sewer service. Why does that matter? Proposition 218 put restrictions on how local governments can fund programs, but carved out flexibility for water, sewer, and garbage programs to make sure these critical services didn't get held hostage by politics. SB 231 clarifies that managing stormwater runoff is a key function of a sewer service, which will allow cities across California to more easily capture and clean stormwater to augment local water supplies and protect our rivers and beaches from untreated stormwater runoff. The PACIFIC INSTITUTE ESTIMATES that capturing storm water in Los Angeles and the Bay Area could together yield 630,000 acre-feet per year in new freshwater — more than Los Angeles' annual water use. Capturing that water, rather than let it continue rushing out to sea, will be essential for preparing California for climate change.
In 2014, California took the historic step of passing the Sustainable Groundwater Management Act (SGMA), becoming the last state in the West to regulate groundwater pumping. However, the SGMA will be phased in over many years, and since its passage more than 3,100 wells in California have gone dry. SB 252 (Dodd) increases transparency about new well drilling applications in critically overdrawn groundwater basins.
California doesn't suffer from a lack of water data, but from a lack of useful water data. Information about hydrology, flows, water quality, water rights and fish abundance are stored in myriad government databases, nearly impossible to compare and contrast. By locating existing state and federal water data on an open and transparent water data platform, water agencies and farmers will more easily be able to transfer water to where its needed most. AB 1755 requires the Department of Water Resources to create such a platform. The bill passed with overwhelming bipartisan majorities in both houses, and was signed into law by Governor Brown.
Measure AA was approved by over 70 percent of Bay Area voters on June 7, becoming the first fully regional ballot measure to be considered (and approved) by voters in all nine counties. Measure AA established a $12 parcel tax on all Bay Area parcels, and will raise $500 million over 20 years to fund wetland restoration, flood protection and pollution prevention projects along the San Francisco Bay. Climate change and 160 years of development are undermining the San Francisco Bay's ecosystem, and threatening the region's coastal residents and infrastructure. A 2015 study estimated the Bay Area is today vulnerable to over $10 billion in damages in the event of an extreme storm event, and will become more vulnerable as sea levels rise.
10/15/12 Commonwealth Club: TEAR DOWN THAT DAM?


text:
Yohei Okuyama (; * 28. Oktober 1999 in der Präfektur Okayama) ist ein japanischer Fußballspieler.

Karriere
Yohei Okuyama erlernte das Fußballspielen in der Jugendmannschaft des Hannan University Club sowie in der Universitätsmannschaft der Hannan-Universität. Seinen ersten Profivertrag unterschrieb er am 2. Februar 2022 bei Iwate Grulla Morioka. Der Verein aus Morioka, einer Stadt in der Präfektur Iwate, spielte in der zweiten japanischen Liga. Sein Zweitligadebüt gab Yohei Okuyama am 27. Februar 2022 (2. Spieltag) im Auswärtsspiel gegen den FC Machida Zelvia. Hier wurde er in der 74. Minute für den Brasilianer Brenner eingewechselt. Machida Zelvia gewann das Spiel durch ein Elfmetertor von Taiki Hirato mit 1:0. Am Ende der Saison 2022 belegte er mit Iwate Grulla Morioka den letzten Tabellenplatz und musste in die dritte Liga absteigen. In seiner ersten Profisaison bestritt er 32 Zweitligaspiele. Nach dem Abstieg wechselte er im Januar 2023 zum Zweitligisten FC Machida Zelvia.

Weblinks

Einzelnachweise

Fußballspieler (Iwate Grulla Morioka)
Fußballspieler (FC Machida Zelvia)
Japaner
Geboren 1999
Mann


text:
Overall, these results suggest that blockade of astrocytic glutam
Overall, these results suggest that blockade of astrocytic glutamate uptake in the PFC is sufficient see more to produce anhedonia, a core symptom of depression. Neuropsychopharmacology (2012) 37, 2467-2475; doi:10.1038/npp.2012.105; published online 27 June 2012″
"Nicotinic acetylcholine receptors (nAChRs) regulate sensitization to stimulant drugs such as d-amphetamine and cocaine.
The current study determined if nAChRs modulate the induction and/or expression of behavioral sensitization to high methylphenidate doses.
In experiment 1, rats received saline or mecamylamine (3 mg/kg, sc), followed by saline or methylphenidate (5.6
or 10 mg/kg, sc) during 10 daily sessions; the effect of methylphenidate (1-17 mg/kg, sc) alone was determined 14 days later. In experiment 2, rats received saline or dihydro-beta-erythroidine (DH beta E; 3 mg/kg, sc), followed by saline or 5.6 mg/kg of methylphenidate. In experiment 3, rats received saline or methylphenidate (5.6 or 10 mg/kg, sc) alone for 10 days; the Silmitasertib in vitro effect of acute mecamylamine (3 mg/kg, sc) on the response to methylphenidate (1-17 mg/kg, sc) was determined 14 days later. Locomotor activity, sniffing, rearing,
grooming, and stereotypy ratings were dependent measures.
Methylphenidate produced dose-dependent increases in locomotor activity, sniffing, and stereotypy on day 1 and these effects were enhanced on day 10, indicative of sensitization. Mecamylamine attenuated methylphenidate-induced stereotypy only on day 1, but reduced locomotor activity, sniffing, rearing, and stereotypy on day 10 and during the methylphenidate challenge phase; similar results were obtained with DH beta E. However, acute mecamylamine did not alter the effects of the methylphenidate challenge following the induction of sensitization
to methylphenidate alone.
Although nAChRs do not appear to regulate the expression of methylphenidate-induced behavioral sensitization, check details inhibition of high-affinity beta 2 subunit nAChRs attenuates the induction of behavioral sensitization to high doses of methylphenidate."
"Composed of 35 amino acids, O3 is the smallest characterized protein encoded by vaccinia virus (VACV) and is an integral component of the entry-fusion complex (EFC). O3 is conserved with 100% identity in all orthopoxviruses except for monkeypox viruses, whose O3 homologs have 2 to 3 amino acid substitutions. Since O3 is part of the EFC, high conservation could suggest an immutable requirement for interaction with multiple proteins. Chordopoxviruses of other genera also encode small proteins with a characteristic predicted N-terminal alpha-helical hydrophobic domain followed by basic amino acids and proline in the same relative genome location as that of VACV O3.
Tests combined MK-801 or the non-competitive nicotinic acetylchol
Tests combined MK-801 or the non-competitive nicotinic acetylcholine receptor antagonist, mecamylamine with either nicotine or saline. Experiment 2b had sucrose delivered on saline sessions and no sucrose on intermixed nicotine sessions followed by MK-801 antagonism tests of the saline CS.
MK-801 and phencyclidine dose-dependently attenuated the CR in Experiment 1. Ro-25,6981
https://www.selleckchem.com/products/jph203.html enhanced the CR, but did not substitute for nicotine. Other ligands showed inconsistent effects. In Experiment 2a, MK-801 pretreatment reduced goal-tracking when given before nicotine and saline test sessions; mecamylamine pretreatment had no effect. In Experiment 2b, MK-801 dose-dependently attenuated the saline-evoked CR.
Combined, the results suggest that MK-801 blocks discriminated goal-tracking by virtue of state-changing properties."
"In this analysis of national polling data, the authors conclude that political candidates who favor cuts in Medicare to reduce the federal budget deficit could face negative electoral
consequences. Two recent government reports show substantial short-term improvements in the financial outlook for Medicare and in the federal budget deficit.(1),(2) However, these forecasts also suggest the need for further action brought about by a worsening of the financial situation after 2015 as the number of Medicare recipients increases from 52 million to 73 million in the decade following.(1)-(3) This EPZ5676 nmr issue is likely to receive considerable attention in the upcoming debate about the federal budget deficit and the national debt. As we reported in the Journal in 2011, there has been little public support for major policy changes aimed …"
"This study was undertaken to determine the presence of aflatoxin M1 (AFM1) in animal milk. In addition, exposure of infants to aflatoxin M1 (AFM1) and lactating mothers to aflatoxin B1 (AFB1) was examined using AFM1 in
breast milk as a biomarker for exposure to AFB1. In total, 100 samples of fresh animal milk and fermented milk (buttermilk) and 80 samples of human breast milk were collected during the period 20112012. An enzyme-linked immunosorbent assay (ELISA) was used for the analysis of milk samples. AFM1 was detected in all animal fresh and OSI-027 concentration fermented milk samples. The concentrations of AFM1 in 70 samples of fresh and fermented milk were higher than the maximum tolerance limit accepted by the European Union and the United States of 50 ng/kg. In human milk samples the average concentration of AFM1 was higher than the maximum tolerance limit accepted by the European Union and the United States of 25 ng/kg. Logistic regression analysis failed to show a correlation between AFM1 and type and amount of dairy consumption, vegetables, fruits, and meat. However, an association between AFM1 and cereal consumption was detected. This study is the first to report on the occurrence of AFM1 in milk consumed by the Jordanian population.
Present data suggest that the generation of sharp wave-ripple (SW
Present data suggest that the generation of sharp wave-ripple (SWRs) requires a complex
interaction between the various components of the hippocampal network with the important involvement of GABA(A) receptor (GABA(A)R)-mediated transmission. The positive modulators of GABA(A)Rs zolpidem and diazepam differ in their selectivity for the various subtypes of GABA(A)Rs. Only zolpidem preferentially binds to alpha 1-containing receptors whereas diazepam, but not zolpidem, also activates alpha 5-GABA(A)Rs. FG-4592 solubility dmso In this study using an in vitro model of SWRs we examined the hypothesis that the two drugs distinctly affect the various characteristics of SWRs. Remarkably, the two drugs displayed opposite effects on the ripple oscillation. Zolpidem enhanced whereas diazepam suppressed ripples. Furthermore diazepam, but not zolpidem, produced a temporal dissociation between ripples and sharp waves. Both drugs suppressed the generation of SWRs in the form of sequences of multiple events (i.e. clusters). It was also observed that
at low concentrations both drugs increased the rate of initiation of episodes of SWR. At high concentration zolpidem but not diazepam continued to increase the rate of episodes of SWRs. We propose that an accurate yet dynamic balance between excitation and inhibition in specific sites of the hippocampal network distinctly regulates the generation of basic features of SWRs such as ripples and sequential LY2874455 DihydrotestosteroneDHT activation of the neuronal assemblies
which have particular functional roles. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved."
"Objective: Most studies of anastomotic technique have been underpowered to detect subtle differences in survival. We analyzed the United Network for Organ Sharing database for trends in use and outcomes after either bicaval or traditional (biatrial) anastomoses for heart implantation.
Methods: Review of United Network for Organ Sharing data identified 20,999 recipients of heart transplants from 1997 to 2007. Patients were stratified based on the technique of atrial anastomosis: standard biatrial (atrial group, n = 11,919, 59.3%), bicaval (caval group, n = 7661, 38.1%), or total orthotopic (total group, n = 519, 2.6%).
Results: The use of the bicaval anastomosis is increasing, but many transplantations continue to use a biatrial anastomosis (1997, 0.2% vs 97.6%; 2007, 62.0% vs 34.7%; P < .0001). Atrial group patients required permanent pacemaker implantation more often (odds ratio, 2.6; 95% confidence interval, 2.2-3.1). Caval group patients had a significant advantage in 30-day mortality (odds ratio, 0.83; 95% confidence interval, 0.75-0.93), and Cox regression analysis confirmed the decreased long-term survival in the atrial group (hazard ratio, 1.11; 95% confidence interval, 1.04-1.19).
(C) 2012 Elsevier B V All rights reserved "
"Parasites like
(C) 2012 Elsevier B.V. All rights reserved."
"Parasites like malaria and Toxoplasma possess a vestigial plastid homologous to the chloroplasts of plants. The plastid (known as the apicoplast) is non-photosynthetic but retains many hallmarks of its ancestry including a circular genome that it synthesises proteins from and a suite of biosynthetic
pathways of cyanobacterial origin. In this review, the discovery of the apicoplast and its integration, function and purpose are explored. New insights into the apicoplast fatty acid biosynthesis pathway and some novel roles of the apicoplast in vaccine development are reviewed."
"To investigate the epidemical characteristics and genotype distributions of bovine rotavirus (BRV) in China, 195 fecal samples were collected from calves with diarrhea in China. Fecal samples were detected for rotavirus A antigen using ELISA. The positive samples were screened for VP7 and VP4 by RT-PCR. G serotyping
and P genotyping Tanespimycin manufacturer were conducted on 53 VP7 IACS-10759 order and VP4 positive samples using RT-PCR. The results showed that 82 samples were found positive for BRV. 752 bp, 660 bp and 285 bp bands were amplified for G-typing. 478 bp, 375 bp and 361 bp bands were amplified for P-typing. The G6 and G10 serotypes were 29(54.7%) and 8 (15.1%) in positive samples for VP7. P[5] and P[11] genotypes were 28 (52.8%) and 10 (18.9%) in the positive samples for VP4. The main combinations of BRV G serotype and P genotype were G6P[5] (28.3%), Erastin G6P[5]P[1] (5.7%), GlOP[5] (5.7%) and GlOG6P[5] (5.7%), respectively. Other combinations (including untypable) of G serotype and P genotype were 54.6%. The dominant G serotype and P genotype were G6 and P[5] respectively. The predominant combination of G and P serotypes was G6P[5]. This has significance for establishing the preventive measures against
diarrhea caused by group A rotaviruses in cattle. (C) 2013 Elsevier B.V. All rights reserved."
"In the current study, primers described previously and modified versions of these primers were evaluated for amplification of full-length gag genes from different equine infectious anemia virus (EIAV) strains from several countries, including the USA, Germany and Japan. Each strain was inoculated into a primary horse leukocyte culture, and the full-length gag gene was amplified by reverse transcription polymerase chain reaction. Each amplified gag gene was cloned into a plasmid vector for sequencing, and the detectable copy numbers of target DNA were determined. Use of a mixture of two forward primers and one reverse primer in the polymerase chain reaction enabled the amplification of all EIAV strains used in this study. However, further study is required to confirm these primers as universal for all EIAV strains. The nucleotide sequence of gag is considered highly conserved, as evidenced by the use of gag-encoded capsid proteins as a common antigen for the detection of EIAV in serological tests.
Variants selleckchem of CISH are associated with susceptibility
to diseases caused by diverse infectious pathogens, suggesting that negative regulators of cytokine signaling have a role in immunity against various infectious diseases. The overall risk of one of these infectious diseases was increased by at least 18% among persons carrying the variant CISH alleles."
"A 57-year-old woman presents to an outpatient clinic for evaluation of hypertension. She has no history or symptoms of cardiovascular disease and reports having gained 15 kg over the past 30 years. Her blood pressure is 155/95 mm Hg, her weight 86 kg, her height 165 cm, her body-mass index (BMI, the weight in kilograms divided by the square of the height in meters)
31, and her waist circumference 98 cm. Her serum triglyceride level is 175 mg per deciliter (2.0 mmol per liter), high-density lipoprotein cholesterol 42 mg per deciliter (1.1 mmol per liter), low-density lipoprotein cholesterol 110 mg per deciliter (2.8 mmol per liter), and glucose 85 mg per deciliter (4.7 mmol per liter). Her clinical profile is thus consistent with the metabolic syndrome. 1 She is a nonsmoker, is sedentary, and eats a diet that is high in white bread, processed meats, and snacks and drinks containing sugars and sodium and is low in fruits and vegetables. She is interested in adopting a healthier lifestyle."
"Background BIBW2992 Variation in and irreversibility of platelet inhibition with clopiclogrel has led to controversy about its optimum dose and timing of administration in patients with acute coronary syndromes. We compared Bcl-w ticagrelor, a more potent reversible P2Y12 inhibitor with clopiclogrel in such patients.
Methods At randomisation, an invasive strategy was planned for 13408 (72.0%) of 18624 patients hospitalised for acute coronary syndromes (with or without ST elevation). in a double-blind, double-dummy study, patients were randomly assigned
in a one-to-one ratio to ticagrelor and placebo (180 mg loading dose followed by 90 mg twice a day), or to clopidogrel and placebo (300-600 mg loading dose or continuation with maintenance dose followed by 75 mg per day) for 6-12 months. All patients were given aspirin. The primary composite endpoint was cardiovascular death, myocardial infarction, or stroke. Analyses were by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT00391872.
Findings 6732 patients were assigned to ticagrelor and 6676 to clopidogrel. The primary composite endpoint occurred in fewer patients in the ticagrelor group than in the clopiclogrel group (569 [event rate at 360 days 9.0%] vs 668 [10.7%], hazard ratio 0.84, 95% CI 0.75-0.94; p=0.0025). There was no difference between clopiclogrel and ticagrelor groups in the rates of total major bleeding (691 [11.6%] vs 689 [11.5%], 0.99 [0.89-1.10]; p=0.
In this study, SILAC quantitative proteomics
was used to
was used to identify differentially externalized proteins in the conditioned media from the mammary fibroblasts CB-839 with or without intact T beta RII. Over 1000 proteins were identified and their relative differential levels were quantified. Immunoassays were used to further validate identification and quantification of the proteomic results. Differential expression was detected for various extracellular proteins, including proteases and their inhibitors, growth factors, cytokines, and extracellular matrix proteins. CXCL10, a cytokine found to be up-regulated in the T beta RII knockout mammary fibroblasts, is shown to directly stimulate breast tumor cell proliferation and migration Overall, this
study revealed hundreds of specific extracellular protein changes modulated by deletion of T beta RII in mammary fibroblasts, which may play important roles in the tumor microenvironment. These results warrant further investigation into the effects of inhibiting the TGF-beta signaling pathway in fibroblasts because systemic inhibition of TGF-beta signaling pathways is being considered as a potential cancer therapy."
"Background: Current Canadian and international guidelines suggest patients with transient ischemic attack (TIA) or nondisabling stroke and ipsilateral internal carotid artery stenosis of 50% to 99% should be offered carotid endarterectomy (CEA) <= 2 weeks of the incident TIA or stroke. The objective of the study was to identify whether these goals are being met and the factors that https://www.selleckchem.com/products/sch-900776.html most influence wait times.
Patients who underwent CEA at the Ottawa Hospital for symptomatic carotid artery stenosis from 2008 to 2010 were identified. Time intervals based on the dates of initial symptoms, referral to and visit with a vascular surgeon, the decision to operate, and the date of surgery were recorded for each patient. The influence of various factors on wait times was explored, including age, sex, type of index event, referring physician, science distance from the surgical center, degree of stenosis, and surgeon assigned.
Results: Of the 117 patients who underwent CEA, 92 (78.6%) were symptomatic. The median time from onset of symptoms to surgery for all patients was 79 days (interquartile range [IQR], 34-161). The shortest wait times were observed in stroke patients (49 [IQR, 27-81] days) and inpatient referrals (66 [IQR, 25-103] days). Only 7 of the 92 symptomatic patients (8%) received care within the recommended 2 weeks. The median surgical wait time for all patients was 14 days (IQR, 8-25 days). In the multivariable analysis, significant predictors of longer wait times included retinal TIA (P = .003), outpatient referrals (P = .004), and distance from the center (P = .008). Patients who presented to the emergency department had the shortest delays in seeing a vascular surgeon and subsequently undergoing CEA (P < .0001).
Five-year EFS for infants was 36, 38, and 43%, respectively
Five-year EFS for infants was 36, 38, and 43%, respectively. DihydrotestosteroneDHT Seminal randomized studies led to a number of important findings. Stronger post-induction intensification improved outcome for both SR and HR patients. With improved systemic therapy, additional intrathecal (IT) methotrexate effectively replaced cranial radiation. For SR patients receiving three-drug induction, iso-toxic substitution of dexamethasone for prednisone improved EFS. Pegylated asparaginase safely and effectively replaced native asparaginase. Thus, rational therapy modifications yielded better outcomes for both SR and HR patients. These trials provide the platforms for current Children's
Oncology Group trials. Leukemia (2010) 24, 285-297; doi: 10.1038/leu.2009.262; published online 17 December 2009″
"Background: The use of valproic acid in the first trimester of pregnancy is associated with an increased risk of spina bifida, but data on the risks of other congenital malformations are
limited.
Methods: We first combined data from eight published cohort studies (1565 Selleck E7080 pregnancies in which the women were exposed to valproic acid, among which 118 major malformations were observed) and identified 14 malformations that were significantly more common among the offspring of women who had received valproic acid during the first trimester. We then assessed the associations between use of valproic acid during the first trimester and these 14 malformations by performing
a case-control study with the use of the European Surveillance of Congenital Anomalies (EUROCAT) antiepileptic-study database, which is derived from population-based congenital-anomaly registries. Registrations (i.e., pregnancy outcomes with malformations included in EUROCAT) with any of these 14 malformations were compared with two control groups, one consisting of infants with malformations PD0332991 research buy not previously linked to valproic acid use (control group 1), and one consisting of infants with chromosomal abnormalities (control group 2). The data set included 98,075 live births, stillbirths, or terminations with malformations among 3.8 million births in 14 European countries from 1995 through 2005.
Results: Exposure to valproic acid monotherapy was recorded for a total of 180 registrations, with 122 registrations in the case group, 45 in control group 1, and 13 in control group 2. As compared with no use of an antiepileptic drug during the first trimester (control group 1), use of valproic acid monotherapy was associated with significantly increased risks for 6 of the 14 malformations under consideration; the adjusted odds ratios were as follows: spina bifida, 12.7 (95% confidence interval [CI], 7.7 to 20.7); atrial septal defect, 2.5 (95% CI, 1.4 to 4.
"Background: Approximately 70% of persons who have an out-
"Background: Approximately 70% of persons who have an out-of-hospital cardiac arrest have underlying acute myocardial infarction or pulmonary embolism. Therefore, thrombolysis during cardiopulmonary resuscitation may improve survival.
Methods: In a double-blind, multicenter trial, we randomly assigned Tideglusib adult patients with witnessed out-of-hospital cardiac arrest to receive tenecteplase or placebo during cardiopulmonary resuscitation. Adjunctive heparin
or aspirin was not used. The primary end point was 30-day survival; the secondary end points were hospital admission, return of spontaneous circulation, 24-hour survival, survival to hospital discharge, and neurologic outcome.
Results: After blinded review of data from the first 443 patients, the data and safety https://www.selleckchem.com/products/ly2874455.html monitoring board recommended discontinuation of enrollment of asystolic patients because of low survival, and the protocol was amended. Subsequently, the trial was terminated prematurely for futility after enrolling a total of 1050 patients. Tenecteplase was administered to 525 patients and placebo to 525 patients; the two treatment groups had similar clinical profiles. We did not detect any significant differences between tenecteplase
and placebo in the primary end point of 30-day survival (14.7% vs. 17.0%; P=0.36; relative risk, 0.87; 95% confidence interval, 0.65 to 1.15) or in the secondary end points of hospital admission (53.5% vs. 55.0%, P=0.67), return of spontaneous circulation (55.0% vs. 54.6%, P=0.96), 24-hour survival (30.6% vs. 33.3%, P=0.39), survival to hospital discharge (15.1% vs. 17.5%, P=0.33), or neurologic outcome (P=0.69). There were more intracranial hemorrhages in the tenecteplase group.
Conclusions: When tenecteplase was used without adjunctive antithrombotic therapy during advanced life support for out-of-hospital cardiac arrest, we did not detect an improvement in outcome, in comparison with placebo. (ClinicalTrials.gov number, NCT00157261.)."
"Background: In men with chronic prostatitis-chronic pelvic pain
syndrome, treatment with alpha-adrenergic receptor blockers early in the course of the disorder learn more has been reported to be effective in some, but not all, relatively small randomized trials.
Methods: We conducted a multicenter, randomized, double-blind, placebo-controlled trial to evaluate the efficacy of alfuzosin, an alpha-adrenergic receptor blocker, in reducing symptoms in men with chronic prostatitis-chronic pelvic pain syndrome. Participation in the study required diagnosis of the condition within the preceding 2 years and no previous treatment with an alpha-adrenergic receptor blocker. Men were randomly assigned to treatment for 12 weeks with either 10 mg of alfuzosin per day or placebo.
Intertypic recombination with other
Intertypic recombination with other MDV3100 order serotypes was observed. This is the first report of the complete genome of EV80 in China."
"Plasmodesmata
(PD) are plasma membrane-lined cytoplasmic channels that cross the cell wall and establish symplasmic continuity between neighboring cells in plants. Recently, a wide range of cellular RNAs (including mRNAs and small RNAs (sRNAs)) have been reported to move from cell to cell through PD trafficking pathways. sRNAs are key molecules that function in transcriptional and post-transcriptional RNA silencing, which is a gene expression regulatory mechanism that is conserved among eukaryotes and is important for protection against invading nucleic acids (such as viruses and transposons) and for developmental and physiological regulation. One of the most intriguing aspects of RNA GSK1120212 silencing is that it can function either cell autonomously or non-cell autonomously in post-transcriptional RNA silencing pathways. Although the mechanisms underlying cell-to-cell trafficking of RNA and RNA silencing signals are not fully understood, the movement of specific RNAs seems to play a critical role in cell-to-cell and long-distance regulation of gene expression, thereby coordinating growth and developmental processes, gene silencing, and stress responses. In this review, we summarize the current knowledge
regarding cell-to-cell trafficking of RNA molecules (including small RNAs), and we discuss potential molecular mechanisms of cell-to-cell trafficking that are mediated by complex networks."
"To date, a number of bacteriophages (phages) infecting Acinetobacter species have been reported and characterized. However, Acinetobacter phages which infect A. soli have not been investigated yet. Here, we report the complete genome sequence of Acinetobacter phage phiAC-1, which belongs to the Myoviridae, infecting Acinetobacter soli strain KZ-1."
"Inulin is a carbohydrate composed of linear chains of beta-2, 1-linked D-fructofuranose molecules terminated by a glucose residue through a sucrose-type linkage
at the reducing end. Jerusalem artichoke (JA) is one of the most interesting materials among unconventional and renewable raw materials, with levels of inulin reaching 50-80% of dry matter. Inulin or inulin-rich materials can be actively hydrolyzed by microbial inulinases click here to produce glucose and fructose syrups that can be used in bioprocesses. In this study, several microbial strains were isolated and their ability to inulinase biosynthesis was evaluated. The novel yeast strain Talf1, identified as Zygosaccharomyces bailii, was the best inulinase producer, attaining 8.67 U/ml of inulinase activity when JA juice was used as the inducer substrate. Z. bailii strain Talf1 and/or its enzymatic crude extract were further applied for bioethanol production and biodesulfurization (BDS) processes, using inulin and JA juice as carbon source.
Conclusion: Stress cardiac tomography performed 5 years after cor
Conclusion: Stress cardiac tomography performed 5 years after coronary artery bypass grafting is useful to characterize the risk of cardiac events
and its temporal variation. Parametric survival model estimates the predicted time to risk and the level of risk at specific time intervals after coronary artery bypass grafting."
"A 44- learn more year-old businessman with a history of hypertension presents for evaluation with a report of being under stress at work and home, which has led to ""unsatisfactory"" sleep. Although there is some despondency, screening for depression is negative. His blood pressure is 158/ 98 mm Hg. Laboratory results include a mean corpuscular volume of 102 fl ( normal range, 80 to 100), an alanine aminotransferase level of 60 U per liter ( normal range, 7 to 41), an aspartate aminotransferase level of 45 U per liter ( normal range, 12 to 38), and a gamma-glutamyltransferase level of 110 U per liter ( normal range, 9 to 58). His physician asks about alcohol consumption, and the patient admits that
perhaps he drinks ""more than he should,"" since he often wakes up with a hangover and arrives late to work. After weekend golf outings, he comes home intoxicated, leading to arguments with his wife and embarrassment in front of his children. He has been quietly wondering about the need to cut down or stop drinking and wants some advice. His physician P5091 mw discusses medication or a referral to an alcohol clinic for further evaluation. Naltrexone is proposed as a treatment option."
"Objective: The implantation MG-132 of a composite graft
is the treatment of choice for patients with aortic root disease if the valve cannot be preserved and the patient is not a suitable candidate for a Ross procedure. Several years ago, the Shelhigh NR-2000C ( Shelhigh, Inc, Millburn, NJ) was introduced in Europe. Being a totally biologic conduit and considering the lack of homografts, the graft seemed an ideal conduit for patients with destructive endocarditis, as well as for older patients who were not suitable candidates for oral anticoagulation.
Methods: From 2001 until 2006, the Shelhigh NR-2000C stentless valved conduit was implanted in 115 patients for various aortic root pathologies. The conduit consists of a bovine pericardial straight graft with an incorporated porcine stentless valve. Aortic root repair was performed during standard cardiopulmonary bypass and mild hypothermia in the majority of patients. Deep hypothermic circulatory arrest combined with selective antegrade cerebral perfusion was used when the repair extended into the arch.
Results: Seven patients with uncomplicated early outcome presented with unexpected sudden disastrous findings at the level of the aortic root, although 1-year follow-up computed tomographic scans were normal. Four of these patients underwent emergency operations because of desintegration of the graft, along with rupture of the aortic root.

redpajama_set_name: RedPajamaCommonCrawl


text:
Three One Zero Teases 'ADR2FT'
Last month Three One Zero revealed that its upcoming first-person survival title, ADR1FT, wouldn't be making its 2015 release window. That was, however, for a good reason; ADR1FT has been 'hand selected' by Oculus VR to feature as part of the launch line-up for the Oculus Rift virtual reality (VR) head-mounted display (HMD) in Q1 2016. There's still a while before VR fans will get to dive into this space story, then, but it appears that the developer is already starting to plan a possible sequel, ADR2FT.
That is according to Three One Zero's Adam Orth, who recently posted an image of a white board bearing the name, as seen below. This could be a brainstorming session for a possible sequel, though it could just as well be a joke on Orth's part. ADR1FT, meanwhile, will be releasing on PC first but is also expected to arrive on PlayStation 4 with support for the PlayStation VR HMD later down the line. Support for the HTC Vive on the PC version is also still thought to be on the way.
ADR1FT is a visually stunning experience in which players are cast as an astronaut that survives a horrific accident on a space station, leaving him stranded and fighting to survive. Players will make their way through the remains of the facility and occasionally out into space itself, finding air canisters to refuel on and more.
VRFocus will continue to follow ADR1FT and the potential ADR2FT, reporting back with the latest updates from Three One Zero.
The post Three One Zero Teases 'ADR2FT' appeared first on VRFocus.
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The surface veneers are made and baked on the top of the glass form.
Two sheets are cut to the shape of the earring veneer: a textured sheet that will become the back, through which I have cut a small slit so the clip-on back can slip through, and a plain sheet that will be sandwiched in the middle, the same thickness as the metal back of the clip-on, with a cutout window that is the shape of the back of the clip-on so that it sits embedded smoothly. Slip the clip-on back through the textured sheet, rotate into proper orientation and set into the cutout on the second sheet. Gently press the two sheets together.
Scratch the surfaces that meet together, on the inside, with a needle tool, apply liquid clay (thin layer), edge with a thin strip of black to give a nice finish, apply your signature, rebake, and you're done, with the clips nicely embedded in the back.
Tomorrow, two finished pairs of earrings to go with their respective necklaces.


How well do you understand patents, the opportunities they create, and the risks that patents can create for your consulting practice?
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Mtg: Technology Trends for Magnetic Storage: What is the Future?
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Sample scripts for configuring Terminal Server settings.
Sample scripts for monitoring Terminal Service performance.
Sample scripts for retrieving information about Terminal Server configuration settings.
Sample scripts for creating, modifying, and deleting Terminal Server user accounts.


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text:
Contemporary China Centre Seminars
Contemporary China Centre University of Westminster
2014 Autumn Semester Seminars
All seminars take place in The Westminster Forum, Fifth Floor, University of Westminster, Wells Street, London W1T
Dr Joanne Smith Finley
'Controlling Terra Nullius: Truth and Consequences of the 'National Partner Assistance Programme' in Xinjiang, China.'
Wednesday 29 October, 5-7pm
Joanne Smith Finley is Senior Lecturer in Chinese Studies in the School of Modern Languages at Newcastle University. Her monograph The Art of Symbolic Resistance: Uyghur Identities and Uyghur-Han Relations in Contemporary Xinjiang (Brill) was published in 2013. She is also co-editor of Situating the Uyghurs between China and Central Asia (Ashgate, 2007).
Dr Heather Inwood
'Contemporary Chinese Literature as Participatory Culture: Viral Verse and Transmedia Worlds'
Wednesday 12 November, 6-8pm
This talk explores the digital transformation of literary practices underway in China by focusing on case studies from contemporary Chinese poetry and popular fiction. Since the 1990s, the rapid growth of the Chinese internet has helped make literature the tenth most popular online activity, ushering in an age of mass participation in the creation and evaluation of literature. This talk considers the implications of participatory literary production for the definition and status of Chinese literature.
Heather Inwood is Lecturer in Chinese Cultural Studies and Undergraduate Programme Director for Chinese Studies at the University of Manchester. Her book, Verse Going Viral: China's New Media Scenes, explores the fate of modern Chinese poetry an age of the internet and consumer culture and was published by the University of Washington Press in 2014.
Guo Xiaolu, in discussion with Professor Chris Berry
'Beyond Identities – Artists as Avatars of Narrative Force'
Xiaolu Guo is a British/Chinese novelist, essayist, filmmaker and poet. As one of Granta's Best of Young British Novelists, Xiaolu has published several novels and short story collections by Random House UK/USA. She has also directed a number of feature films and documentary essays. Her first feature, How Is Your Fish Today, a hybrid of documentary and fiction, was selected at the 2005 Sundance Film Festival and received Grand Jury Prize at the International Women's Film Festival in Pairs. Her second feature She, A Chinese, a homage to Godard's La Chinoise, received the Golden Leopard Award at Locarno Film Festival. Late At Night: Voices of Ordinary Madness is her most recent essay film, selected for the London Film Festival and the National Gallery of Art in Washington DC in 2014.
Please note that non-University of Westminster attendees for any of the following seminars should register with Helena Scott at h.scott@westminster.ac.uk
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text:
Cato At Liberty
Our Enemies or Our Allies?
By Malou Innocent
The New York Times reports that congressional investigators have found mounting evidence that "American taxpayers have inadvertently created a network of warlords across Afghanistan who are making millions of dollars escorting NATO convoys and operating outside the control of either the Afghan government or the American and NATO militaries."
The Financial Times broke this story back in March. But their most startling discovery was that after nearly a decade at war in Afghanistan, Washington still has no clue as to who its true enemies (and allies) are.
Many Americans would be surprised to learn that some prominent Afghan officials are in fact saboteurs of America's presumptuous and dangerously quixotic nation‐building endeavor, instituting policies that feed the insurgency's momentum in order to get more economic assistance from the coalition. America's Ambassador to Kabul, Karl W. Eikenberry, said as much last November. Eikenberry warned (of course, to no avail), that Afghan President Hamid Karzai, "continues to shun responsibility for any sovereign burden…He and much of his circle do not want the U.S. to leave and are only too happy to see us invest further." [Emphasis added]
Karzai knows very well that once the conflict ends, his open aid spigot will dry up. Indeed, Karzai has become notorious for replacing and undercutting people in his government who become too well‐liked and "clean," fearing these officials will become more popular than himself. Such double‐gaming leads us to Karzai's younger half brother, Ahmed Wali Karzai.
He consolidates his power base by acting as the powerful chairman of Kandahar's provincial council, as well as relying on a mafia‐like network of militias, many of whom demand bribes from security companies that benefit from U.S. contracts. The rise of these militia fiefdoms have profited handsomely with foreign taxpayer dollars. "You have about 30 oligarchs who have built little empires with ISAF money," Carl Forsberg, a researcher at the Institute for the Study of War, told the Financial Times. "We are ultimately creating a shadow government."
Lamenting America's strategic paradox, Congressman John F. Tierney (D‑MA), chair of the U.S. House National Security and Foreign Affairs Subcommittee said recently: "In this case, the U.S. appears to be inadvertently fueling the very warlordism and corruption that we are pressing President Karzai to curtail."
U.S. officials say perceptions that power in Kandahar is concentrated in the hands of the Karzai family's ethnic Pashtun Popalzai tribe fuel support for the insurgency. According to a Pentagon assessment released April 28, Afghan public perceptions of Karzai's anti‐corruption efforts are "decidedly negative" and extend to international forces and the international community. U.S. defense officials also find that the "exploitative behavior" of some Afghan officials contributes to the insurgency's success.
For far too long, U.S. officials and analysts have concentrated their focus on Pakistan. As regional expert Steve Coll notes, "If you think about it, the United States is essentially waging a proxy war against its own ally. The Taliban are a proxy of the government of Pakistan. We are an ally of the government of Pakistan. We are fighting the Taliban."
But government officials in Kabul also fit into this equation; unfortunately, this is a government that Washington still endeavors to support.
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text:
Der Mountain View Corridor ist eine im Ausbau befindliche Straße im Norden des US-Bundesstaates Utah. Sie führt entlang der westlichen Peripherie vom Salt Lake County und von Süden nach Nordwesten des Utah County. Bis auf ihre letzten vier Meilen an den südlichen Enden sind Mountain View Corridor und Utah State Route 85 (SR-85) gemeinsam geführt. Zuständig für den gesamten Mountain View Corridor ist das Utah Department of Transportation (UDOT).

Geschichte
Bevor 2010 der Bau des Mountain View Corridor begann, hatten andere Straßen die Bezeichnung "Utah State Route 85". Von 1960 bis 1977 war die ehemalige Nummer 85 die eines State Highways vom Südosten des Box Elder County, nahe der Interstate 15, nordöstlich bei Brigham City bis an die Staatsgrenze vor Franklin. Zuvor trug die Nummer 85 zwischen 1945 und 1953 ein Highway in der Südhälfte des Box Elder Countys, der von der damaligen SR‑41, der heutigen SR‑13, bis zur damaligen SR‑154 in Riverside führte.

Verlauf
Der Mountain View Corridor ist eine im Abstand von ein bis zwei Meilen parallel verlaufende Ausfallstraße westlich des Bangerter Highway (SR-154), gebaut um dem Bedarf der wachsenden Städte im Salt Lake County gerecht zu werden. Er beginnt an der SR-73 in Saratoga Springs und verläuft als SR-85 nach Norden bis zur Kreuzung mit der 2100 North, die im Osten zur Interstate 15 und nach Lehi führt.

Von der Kreuzung der 2100 North wird der Mountain View Corridor weiter nach Norden durch Camp Williams im Salt Lake County verlaufen, westlich der Redwood Road (SR-68). Nördlich von Camp Williams wird er nordwestlich bis zum Porter Rockwell Boulevard in Bluffdale führen. Der Porter Rockwell Boulevard wird eine nicht-autobahnähnliche Zubringerstraße des Mountain View Corridor nach Osten werden, um die Redwood Road (SR-68) etwa auf Höhe der 16000 South anzubinden. Diese wird vorerst die südlichste Anbindung des Mountain View Corridor sein, bis weitere Abschnitte im Süden fertiggestellt sein werden.

Von Porter Rockwell Boulevard wird er weiter nach Nordwesten bis zur 13400 South bei etwa der 4800 West in Riverton und weiter nördlich bis zur 12600 South führen. Von der 12600 South wird er wieder nach nordwestlich verlaufen und den Daybreak Parkway etwa an der 11700 South überqueren. Daybreak – ein Stadtteil von South Jordan am Old Bingham Highway queren, etwa an der 10200 South in West Jordan und verläuft weiter nach Nordosten bis zur 9000 South, unmittelbar westlich der 5400 West.

Von der 9000 South führt er nach Norden, über der 8200 South, bis zur 7800 South, wo er nordwestlich zur 7000 South bei der 6400 West abbiegt. Von der 7000 South geht es nach Norden über die 6200 South zur 5400 South (SR-173). Von der 5400 South wird er wieder nach Nordosten abbiegen, bis zur 4100 South, wo er West Valley City erreicht und etwa an der 5700 West und wieder Richtung Norden zur 3500 South (SR-171) führt und weiter zur Kreuzung mit der SR-201.

Von SR-201 wird er weiter nach Norden bis zur California Avenue in Salt Lake City führen und wieder nordwestlich verlaufen, bevor er an die Interstate 80 Salt Lake City International Airport, nahe der 6100 West in Salt Lake City, ein paar Meilen westlich des Flughafens Salt Lake City International Airport führt.

Ausbau

Planung

In der Jahresmitte des Jahres 2010 diskutierten die Planer im Utah County die zukünftigen einer westlich gelegenen autobahnähnlichen Straße im Utah County zwischen Lehi und Santaquin, entlang der SR-68 und des Utah Lake. Es wurde vermutet, dass dies Teil des Mountain View Corridor Projekts werden würde.

Die Pläne sehen den Ausbau in drei Abschnitten vor. Nach der endgültigen Fertigstellung wird die Autostraße fünf Fahrspuren in jeder Richtung haben, darunter eine mautpflichtige Fahrspur für hohe Belegung High-Occupancy Toll lane (HOT). Einige Abschnitte werden auch zweispurige Straßen auf beiden Seiten der Autostraße umfassen.

Maut für unterbesetzte Fahrzeuge auf der Überholspur
HOT-Fahrspuren gibt es bereits in Utah und einigen anderen Staaten der USA. Die Bedingung ihrer Benutzung ist nicht wie bei HOV-Fahrspuren eine Mindestmenge an Personen im Fahrzeug, sondern die elektronisch abgerechnete Maut zu entrichten und das Maut-Abrechnungsgerät im Fahrzeug zu betreiben, wobei vollbesetzte Fahrzeuge von der Maut ausgenommen werden, aber die Maut eine Möglichkeit eröffnet, die reservierte Fahrbahn für Alleinfahrer gegen Entgelt mitzubenutzen und zugunsten der restlichen Fahrspuren besser auszulasten. Dagegen sind Express toll lanes (ETL) grundsätzlich mautpflichtig.

Bauabschnitt 1: Aus Kostengründen zuerst nur Außengassen

In der ersten Phase werden für jeden Abschnitt der gesamten Länge des Mountain View Corridor entweder die parallelen Zubringer ("Außengassen" oder "Frontage Roads") als zwei getrennte Einbahnstraßen gebaut, jedoch nicht alle auf einmal. Der erste Bauabschnitt wird in den verschiedenen Straßenabschnitten fertiggestellt werden, je nach Bedarf und Finanzierung. Die beiden Zubringer der Autostraße werden in jede Richtung für diese Abschnitte zuerst gebaut. Bei jedem zukünftigen Verkehrsknotenpunkt verlaufen die Fahrbahnen bis zu den Kanten der Vorfahrtsstraße so, dass sie die zukünftigen Rampen der Anschlussstellen werden, wodurch zwei seitlich gelegenen Kreuzungen in Form einer Split Intersection entstehen. In diesen Abschnitten befinden sich zwei Einbahnstraßen auf beiden Seiten der geplanten Autostraße, die später die Frontage Roads sein werden. An jedem künftig ausgebauten Knotenpunkt werden die Anschlussstellen ins Straßennetz nach texanischem Vorbild auf die Frontage Road führen, die die Rampen der Anschlussstelle ersetzen und parallel zur Autostraße verlaufen und diese mit anbinden. Damit werden aus den höhengleichen Split Intersections Autobahnanschlussstellen in Form einer Raute.

Zwischen dem Old Bingham Highway und dem Porter Rockwell Boulevard sowie zur 2100 North werden quer zum Mountain View Corridor verlaufende Zubringer gebaut. Im gesamten ersten Bauabschnitt werden nur die angebundenen Frontage Roads der geplanten Straße errichtet.

Bauabschnitt 2: Ausbau wie in Texas

Im zweiten Bauabschnitt wird erst die eigentliche Autostraße errichtet, sobald Bedarf und Finanzierung vorhanden sind. Durch den Bau der Frontage Roads wird in einer für Utah erstmaligen Art und Weise im ersten Bauabschnitt der Platz in der Mitte der Fahrbahnen reserviert, auf dem später die Brücken mit den Zubringern und die eigentlichen Autobahntrassen errichtet werden sollen. Auch wenn sie wie geplant gebaut werden würden, so käme es während des zweiten Ausbauabschnitts nur zu minimalen Behinderungen des Verkehrs.

Bauabschnitt 3: Mehr Spuren und eine mautpflichtige wie in Kalifornien

Der dritte Ausbauschritt sieht vor, die Autostraße von zwei auf fünf Spuren in jede Richtung zu erweitern, wobei eine dieser Spuren als HOT-Spur – eine mautpflichtige HOV-Fahrspur – reserviert werden wird, die wiederum nach Bedarf und Finanzierung errichtet werden wird.

Baufortschritt
Die Umweltverträglichkeitserklärung für die Autobahn wurde im November 2008 erstellt, die Finanzierung der Autobahn blieb das größte Hindernis. Frühere Vorschläge beinhalteten die Erhöhung der staatlichen Kraftstoffsteuer oder die Erhebung einer Maut auf die neue Straße in einer öffentlich-privaten Partnerschaft, was ein sehr umstrittenes Thema war. Letztendlich entschied die Regierung von Utah, den Bau des Freeways von zukünftigen Steuereinnahmen abhängig zu machen. Der erste Bauabschnitt begann Mitte 2010 und wurde am 15. Dezember 2012 fertiggestellt.

Der Bau des Zubringers, der entlang der 2100 North ins Straßennetz von Lehi führt und die eventuelle Anbindung der Interstate 15 startete Ende 2010. Dieser Zubringer, der zunächst nur bis zur Redwood Road (SR-68) führte, wurde am 24. September 2011 eröffnet. Im zweiten Bauabschnitt wird dieser nach Westen verlängert werden.

In Herriman wurden zwischen dem Rosecrest Drive und der 12600 South zwei Frontage Roads gebaut, die am 2. Juni 2012 für den Verkehr freigegeben wurden. Eine weitere sieben Meilen lange Frontage Road ist fast fertig und wird voraussichtlich am 13. Oktober 2012 geöffnet sein. Diese zusätzlichen Teile werden die vom Porter Rockwell Boulevard in Bluffdale nach Norden bis zum Old Bingham Highway in West Jordanien befahrbare Verlängerung sein. Es wird erwartet, dass Ende 2012 noch weitere sechs Kilometer von der Straße in Richtung Norden fertiggestellt werden. Bis zum Ende des Jahres 2012 werden im ersten Bauabschnitt insgesamt 15 Meilen Frontage Roads, die sich vom Porter Rockwell Boulevard im Norden bis zur 5400 South in West Valley City erstrecken, sowie die damit verbundenen Rad- und Fußwege eröffnet sein.  Im Jahr 2016 wurde die 5400 South (SR-173) angebunden und der Bau wurde in nördlicher Richtung fortgesetzt.

Während das UDOT für den Rest des gesamten Projekts keinen spezifischen Zeitplan vorlegte, wird davon ausgegangen, dass es bis 2030 vollständig abgeschlossen sein wird.

Derzeitiger Ausbau

Der erste Bauabschnitt des Mountain View Corridor ist vollständig abgeschlossen. Die Abschnitte wurden für den Verkehr in zweispurigen getrennten Richtungsfahrbahnen mit höhengleichen und ampelgeregelten Split Intersections gebaut, die später ausgebaut werden können, freigegeben. Die Fahrbahn, die derzeit gebaut wird, erstreckt sich von der Redwood Road (SR-68) bis zur 4100 South. Der Abschnitt zwischen 5400 South und 4100 South wurde am 18. November 2017 um 15:00 Uhr mit einer öffentlichen Feier und einer Rede des Bürgermeisters von West Valley City eröffnet. Der Mountain View Corridor wird voraussichtlich bis  2021 zur SR-201 fertiggestellt sein. Wann die Anbindung zur Interstate 80 fertig sein wird, ist offen.

Liste der Anschlussstellen
In der folgenden Tabelle sind die Anschlussstellen des Mountain View Corridor bei vollem Ausbau aufgeführt.

Weblinks
 Das Mountain View Corridor Projekt beim UDOT
 Mountain View Corridor Phased Implementation Plan

Einzelnachweise

85
Bauwerk im Salt Lake County
Bauwerk im Utah County
Utah State Route 085


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The Toon Crier
Newcastle United Links: St. James' Park, Alan Pardew and Bojan Krkic Edition
By Jim McMeachin Nov 11, 2011, 3:12pm GMT
Share All sharing options for: Newcastle United Links: St. James' Park, Alan Pardew and Bojan Krkic Edition
Hey-- he looks like that one guy from Big Bang Theory!
The sun has risen another day on the Geordie Nation, and despite some people's best efforts it is hard not to be excited that the Mags are still sitting in third place in the Premier League on 25 points from 11 matches. In the links today, we will begin the process of putting the St. James' Park Debacle to bed and moving forward towards Manchester City and England's version of THUNDERDOME™. Undefeated gladiators meet on the pitch with it all to play for. Two clubs enter, one club leave. Well, unless they draw. That, however, is a lot less fun and doesn't really remind me of a great 80's movie.
Putting SDA to bed. (The new name for St. James' Park, not the church)
James Lawton: Newcastle fans: deal with it. That's modern football for you - News & Comment - Football - The Independent
Submitted without comment.
Fans still simmer over stadium name change - Local News - Shields Gazette
Brick fan condemns Sports Direct Arena bid - Chronicle News - News - ChronicleLive
WeeJohn1977 said: "Renaming the stadium makes perfect business sense. But Newcastle United is not a Business to the fans, and there lies the great problem. St James' Park is not just a name, but a source of great pride to the people, representing the history and passion at the very heart of the Geordie nation."
I believe that this is my preferred read on the fan reaction to the name change. We all know what we know and understand the reality behind the current economic climate. I think that the Chronicle has really put together the most responsible reaction here.
Back To Squad News
How Alan Pardew won over a sceptical squad - NUFC Latest News - Newcastle United - ChronicleLive
In a separate article that didn't have much substance so I didn't end up linking it, a poll of fans on the Chronicle shows that 94% now believe that Alan Pardew was the correct hire following Chris Hughton's sacking. That there is a hell of an approval rating.
Steven Taylor: NUFC now completely united - NUFC Latest News - Newcastle United - ChronicleLive
The dressing room is still united. It seems that this prolonged undefeated run at the beginning of the season has left the press a little at a loss as far as ideas regarding Newcastle United. No one really knows what to do with us, and so we have a united locker room, great team spirit, or will plummet down the table sooner rather than later. Speaking personally, I'm not sad to read re-hashed ideas over and over if it means we keep flying high in the league.
Shola Ameobi and Leon Best may play at City - NUFC Latest News - Newcastle United - ChronicleLive
Adding to the possibility that Yohan Cabaye will be ready, there is a double striker boost as well. Moving from a potential source of nervousness regarding fitness to a more normal area is good. City is still going to be an uphill slog, but I'll feel a little better with Best/Ba at the top.
'Sammy's a better player than me' – Shola - Black & White - Jarrow and Hebburn Gazette
The Ameobi brothers really like to talk about each other. This time it's Shola's turn to heap praise on his little brother.
Magpies chase Roma forward | Football News | Transfer Rumours | Sports News
I'm seeing reports linking us to a move for Bojan Krkic of Roma. Bojan was perhaps the absolute hottest young prospect in the world a couple of years back. . . He is only 21, is now more of a striker/winger hybrid (much like almost every other player linked with or purchased by Newcastle United lately) and has loads of potential. In other words, he is exactly the kind of player (in a vacuum) that we would acquire. The problem, however, is the transfer structure that is currently in place between FC Barcelona and AS Roma. The deal with all of it's twists and return purchase clauses and such ends up being worth a healthy £40m total. . . which means unless there is some kind of amazing deal made on our end, this one is a non-starter... but it is a fairly nice thought.
Is Fabio Capello Ignoring The Northeast?
Is the North East really hard done by when it come to the England squad? - NUFC News - NUFC - JournalLive


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