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Republican Bill Weld on His Plans to Stop 'Insecure Bully' Donald Trump From Making It to the 2020 General Election
By Alexandra Hutzler On 3/26/19 at 3:54 PM EDT
Former Massachusetts Governor William Weld speaks to the media at the latest installment of Politics & Eggs at the Bedford Village Inn in Bedford, NH on Feb. 15, 2019. The Politics & Eggs series is a forum for presidential candidates, political leaders, and other political analysts and commentators as they visit New Hampshire, home of the nation's first presidential primary. Weld, the former two-term governor of Massachusetts, said Friday he is launching a presidential exploratory committee, taking a formal step to become the first Republican to directly challenge President Trump in the 2020 GOP primary. Suzanne Kreiter/The Boston Globe via Getty Images
U.S. Donald Trump 2020 Election Trump
Bill Weld has always felt like he could "start Monday" as president of the United States, but he never thought it was truly necessary to turn the fantasy into a reality. That is until Donald Trump came along.
"Most of the people I know are extremely upset about the idea of six more years of Trump—including me," Weld told Newsweek. "I just think it would be terrible for the country."
The 73-year-old former governor of Massachusetts is the first Republican to form an exploratory committee for a presidential run, posing a potential threat to Trump's otherwise clear path to the party's nomination and possible re-election. In his official announcement last month, Weld said he believed that the nation was in serious trouble and that he could not "sit quietly on the sidelines any longer."
Weld intends to make a final decision in April on whether to launch a campaign, and, if he chooses to move forward, he will "run as hard as I can." After all, he's not afraid of a schoolyard bully like Trump, he said.
"Once you've been head of the criminal division of the Justice Department, you're not really scared of anybody," he said. "You know, 'Sticks and stones may break my bones, but names will never hurt me.'"
While he may not be a nationally recognized politician, Weld is a steady figure in the GOP establishment. He began his decades-long career in conservative politics serving as a U.S. attorney for Massachusetts during the Ronald Reagan administration, and he worked his way up to lead the criminal division at the Department of Justice.
He then spent six years as governor of Massachusetts, where he built a reputation for being fiscally conservative and socially liberal. In 2016, Weld was the Libertarian Party's nominee for vice president, sharing the ticket with Gary Johnson.
Still, he undeniably faces an uphill battle against a party that is hooked on Trump. According to Gallup, the president has earned a 90 percent approval rating among Republicans since mid-February. In fact, since taking office in January 2017, Trump has rarely fallen below 80 percent approval among his conservative base.
Plus, the Republican National Committee issued a nonbinding resolution last month declaring the party's undivided support for the president heading into 2020. The committee bluntly added that any challenges to Trump's nomination are bound to go "absolutely nowhere."
But Weld takes a certain amount of pride in being starkly different from the president. He supports action on climate change, extending employment-based immigration visas, and global trade pacts like the Trans-Pacific Partnership (an agreement Trump quickly abandoned in 2017).
Speaking before the release of a summary of special counsel Robert Mueller's report, which found no collusion between Russia and the president's campaign, Weld said he was confident that Trump would continue to face legal troubles that may cloud his ability to run a re-election campaign.
"Take whatever stats you want for the president's current popularity—that's a photograph in time, but six months is forever in national politics," Weld said. "All of the Justice Department's shoes have not yet dropped. The talk about impeachment has not run its course. I think it's very unlikely that the picture will look the same in six months as it does now."
Weld spoke to Newsweek about his possible 2020 run, his thoughts on Trump and what he would do differently if elected president.
When did you first start thinking about challenging Donald Trump in a Republican primary?
We know a lot more about how Donald Trump would act in office now than we did two years ago. I wouldn't have had this idea the day after the election. Most of all, it's a degree of spleen being displayed in the White House. He just can't get enough of demonizing people and attacking people, even individuals. I am one of those people who thinks the essence of democracy is that the individual shall not be thrust in a corner. Well, that's always his first reaction, to thrust the individual in a corner.
What are Trump's biggest vulnerabilities among his Republican base that you believe you can capitalize on?
The sounds that were dog whistles during the campaign, now they're bullhorns. He really does act like a bully, and bullies are generally insecure. I think he's insecure. I said during the '16 campaign that I had questions about whether he was sufficiently stable to be the chief executive officer of the United States, and I haven't seen anything to make me see fit to change that opinion.
You served as the head of the criminal division at the Justice Department in the Reagan administration. How do you feel about Robert Mueller's handling of the Russia investigation, and what do you make of the president's attacks on his own agency?
Bob is very thorough, very professional. He never hot dogs anything, and he's behaved that way in his current position, just as he did in the Justice Department both in my office and then for 12 years as head of the FBI. He's the consummate professional, and, again, sorry to be so negative, but Donald J. Trump is the opposite of a consummate professional. He's a braggart, he's a phony, he's a fake. So there's quite a contrast between the two men. [Laughs.]
As governor, you supported environmental regulations and gun control. Do you plan on making those policies a focus of your platform?
The president's claim that climate change is a hoax is ludicrous. The science is not really debatable. If I won the job, I would put us back in the Paris [climate] accords immediately and cause the country to adopt 2050 CO2 standards that are consonant with what other industrialized countries have done. I think the president just doesn't understand that our mountains and streams and rivers and valleys, they are our cathedrals. We don't have the historical monuments that Europe has, but we have natural monuments, and we better damn well take care of them or they're going to disappear.
In the 1990s, you nearly became the U.S. ambassador to Mexico. Do you agree with Trump's calls for a border wall and his stance on immigration?
No, absolutely not. Almost any state governor will tell you that without in-migration of a workforce through Mexico...we can't populate the agriculture industry or the construction industry in the western part of the United States. I think what we need is a more robust guest-worker program, such as [the one] Canada has. People come in, they work for a few months, and they go back to deal with their families.
Mr. Trump and others who are anti-immigrant—in fact, anti-foreigner all along the line—they have made up this straw man, this boogeyman of "Oh, 11 million illegal aliens demanding immediate citizenship." Most of those people don't want to be citizens; they just overstayed their visa because we kick them out too quick. We need to extend those work visas.
These ideas seem almost progressive in conservative politics today. Do you think the Republican Party has gone off the rails during the Trump presidency?
Yes, I sure do. It doesn't look like the party of Lincoln. You know, I like to think that I belong to the party of Lincoln and the party of Teddy Roosevelt and the party of Ronald Reagan and the party of Dwight Eisenhower. That's the party I registered for when I was 18 years old.
Another thing that is going to sound progressive, but really isn't, is that I think we should have as many people as possible vote in this country. I think we need a new means of voting, and we should take a good look at mobile voting—don't laugh, it means you can vote on your cellphone. You'd have to put in adequate security measures, like a copy of your passport or driver's license on file. Whatever security guarantees are necessary.
I don't really see an argument against having many more people vote. I don't think that if people are too discouraged to vote that that's a good thing. And I'm afraid a lot of people are too discouraged or disgusted to vote. Not good for the Republican Party, not good for the polity.
Would you support getting rid of the Electoral College?
I'm not so sure about that one.
If Trump were to win the Republican Party's nomination, would you encourage Americans to vote Democrat during the general election?
Well, I would not endorse Mr. Trump, let's put it that way.
What further damage do you think Trump can do if elected for another four years?
I think he's not really in favor of democracy, he's in favor of autocracy. He's expressed admiration for President Kim [Jong Un] of North Korea because "what a strong kid he is, he killed his uncle, he killed his brother, that's strength." [Rodrigo] Duterte in the Philippines personally kills people suspected of trafficking in narcotics; he holds the gun and shoots them. [Vladimir] Putin in Russia, whatever else you may think of him, he's certainly an autocrat—and I think most Americans probably don't think a lot of good things about him, but I know one who does and that's Donald Trump, who just melts when he's around Putin.
Andy McCabe, the guy who was number two at the FBI, he kind of had it right when he said that Mr. Trump may not be a Russian asset, meaning an agent, but he might as well be.
This interview has been edited and condensed for length and clarity.
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2017 – astronauts set foot on Mars.
20 years later colonisation has begun, mining is in full swing, and the goals of scientific research are becoming muddied with profit and survival.
Competing factions are growing stronger, and the engineers and scientists of the United Nations Space Co-ordination Agency are finding that even they are not immune from the petty politics of the red planet.
Outpost Mars is a roleplaying game set on this newly-settled planet. Players take the roles of scientists, engineers and explorers going about their business of investigating Martian phenomenon and avoiding death or serious injury while doing so.
The real story focus, however, is on the player characters and their motivations. Trapped on Mars, working in isolation with the other player characters in the team, games will pick up on and revolve around a character's personal interactions with his team-members. On their rivalries, secrets, hidden agendas, lies and on their mutual interests. There are factions and social organizations on Mars with their own agendas and plans. From the ESA to NASA, the Red Legion to the Rovers. A player must, during character generation, ally his character with one of these group and choose a faction that reflects his goal. If the character wants to keep Mars pure and unspoilt then he can ally with the terrorist group called the Red Legion.
The choice a player makes about his character's allies and personal agendas is perhaps the most important part of the character creation process. His ally group will provide the character with objectives to achieve, special information, tasks that need accomplishing, rivals to watch out for - indeed an entire agenda. Of course, the character's choice of ally group needs also to colour and support his background, his personality and his skills. A law-abiding engineer will not want to associate with the destructively criminal Red Legion, for example. Beautifully illustrated with NASA commissioned art-work.


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Latest Syrian armed forces News
Car-bomb attack in northern Syria kills 3 Turkish soldiers
ANKARA, Turkey (AP) — A car bombing has killed three Turkish soldiers in a Turkish-controlled area in northern Syria, Turkey's Defense Ministry said. The ministry said the attack occurred late on Thursday as the soldiers were carrying out road checks in northern Syria, in an area that is under the control...
Turkey says 4 of its soldiers killed in northeast Syria
Jan. 9, 2020 6:30 AM EST
ISTANBUL (AP) — Turkey's defense ministry says four Turkish soldiers have been killed in northeastern Syria. The ministry said the soldiers were killed in a car bombing attack Wednesday while they were conducting road checks. The Turkish military death toll stands at 20 since October, when Turkey launched...
Russia's Putin visits Syria to meet Assad, a key Iran ally
DAMASCUS, Syria (AP) — Russian President Vladimir Putin traveled to Damascus on Tuesday for a meeting with President Bashar Assad, a rare visit that comes amid soaring tensions between Iran and United States following the U.S. drone strike that killed a top Iranian general. While the official statements...
Iranian general transformed Syria's war in Assad's favor
BEIRUT (AP) — When Syrian President Bashar Assad made a rare visit to Tehran last year, the powerful Revolutionary Guard commander Qassem Soleimani was there to greet him, along with Iran's supreme leader and president. Iran's foreign minister wasn't, and he resigned in protest at being excluded from talks...
Iran vows revenge for US attack that killed powerful general
Jan. 3, 2020 10:07 PM EST
BAGHDAD (AP) — Iran promised to seek revenge for a U.S. airstrike near Baghdad's airport that killed the mastermind of its interventions across the Middle East, and the U.S. said Friday that it was sending thousands more troops to the region as tensions soared in the wake of the targeted killing. The...
UN council to hear latest on offensive in Syria's Idlib
UNITED NATIONS (AP) — The U.N. Security Council is going to receive a closed briefing on the ongoing offensive in the last rebel stronghold in Syria at the request of France and the United Kingdom. Vietnam's U.N. Ambassador Dang Dinh Quy, the council president for January, told a news conference...
Shelling hit school killing 6 in rebel-held Syrian village
BEIRUT (AP) — Syrian government forces shelled a rebel-held village in the country's northwest on Wednesday, hitting a school and killing at least six people, opposition activists said. The attack in Idlib province, the last rebel stronghold Syria, was part of an ongoing offensive in which Syrian troops...
BAGHDAD (AP) — An Iranian-backed Iraqi militia vowed Monday to retaliate for U.S. military strikes in Iraq and Syria that killed 25 of its fighters and wounded dozens, raising concerns of new attacks that could threaten American interests in the region. The U.S. attack — the largest targeting an...
Dec. 30, 2019 2:23 AM EST
WASHINGTON (AP) — President Donald Trump starts the new year knee-deep in daunting foreign policy challenges at the same time he'll have to deal with a likely impeachment trial in the Senate and the demands of a reelection campaign. American troops are still engaged in America's longest war in...
WASHINGTON (AP) — The U.S. carried out military strikes in Iraq and Syria targeting an Iranian-backed Iraqi militia blamed for a rocket attack that killed an American contractor, Defense Secretary Mark Esper said Sunday. Secretary of State Mike Pompeo said the strikes send the message that the U.S. will...
Pottsville News
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Badges and Tabs
Information about the Combat Medical Badge
I. DESCRIPTION: An oxidized silver badge 1 inch in height and 1 ½ inches in width, consisting of a stretcher crossed by a caduceus surmounted at top by a Greek cross, all on and over an elliptical oak wreath. Stars are added to indicate subsequent awards; one star at top for the second award, one star at top and one at bottom for the third award, one star at top and one at each side for the fourth award.
II. SYMBOLISM: The Medical Corps insignia of branch, modified by the addition of a Greek cross suggesting the Geneva Convention between the wings and the entwined serpents, signifies the recipient's skills and expertise. It is superimposed upon a stretcher alluding to medical field service. The oak symbolizes steadfastness, strength and loyalty.
III. AWARD ELIGIBILITY: Awarded to members of the Army Medical Department, Naval Medical Department, Air Force Medical Service or Special Forces Medical Sergeant who are in the grade of Colonel or below while assigned or attached to a medical unit of company or smaller size organic to an infantry/special forces unit during any period the unit was engaged in active ground combat subsequent to 6 December 1941. Only one award is authorized for service in Vietnam, Laos, the Dominican Republic, Korea (subsequent to 4 January 1969), El Salvador, Grenada, Panama, Southwest Asia and Somalia, regardless of whether an individual has served in one or more of these areas. Specific eligibility requirements by geographic area are listed in Army Regulation 600-8-22.
IV. DATE APPROVED: The Combat Medical Badge was approved on 29 January 1945. In February 1951, the proposal to designate the badge as a one-time award was rescinded and it was approved for subsequent award during specified periods. The addition of stars to indicate subsequent awards was also approved.
V. SUBDUED BADGES: Subdued badges are authorized in metal and cloth. The metal badge is black. The cloth badge has an olive green base cloth with the stretcher, caduceus, cross, wreath and stars embroidered in black.
VI. MINIATURE BADGES: A dress miniature badge, 19/32 inch in height is authorized.
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River Towns
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The Town of Parmele was established primarily as the junction point for two railroad systems which later became part of the Seaboard Coast Line system. After many proposals of where to place the junction point, it was decided to place it in the vicinity of what is now Parmele. The name Parmele was derived as a result of the Parmele-Eccleston Lumber Company, which located itself in the area around 1890 when the railroad branch line to Greenville was completed. Mr. E. A. Parmele of New York constructed the large steam mill in an area known for its trees. In 1892, another branch line extended to Washington from Parmele, making it a flourishing railroad junction city in its day. It was previously known as "Junction". At one time during the 1890's, Parmele had up to 11 passenger trains, as well as several freight trains, passing through daily.
The Town of Parmele was officially incorporated on February 14, 1893. The first mayor of the town was William Powell, who served from 1893 until 1906. The three initial commissioners were: David S. Powell, R. F. Gaines, and G. J. Cherry. The town also had a constable, which at times were referred to as a chief of police or policeman. This position also served as tax collector at most times. Mayor Lula Council was the first African American female mayor of Parmele and served from 2003 to 2015. The current mayor, Jerry M. McCrary, has served since 2015 as approximately the 15th mayor in succession.
The current town hall building was constructed in 1971 at a total cost of $2,785 by James Pitt, who was the first African-American man elected to a Martin County town's governing board in modern times. Pitt later became the town's mayor in January 1974 until 1981. The other half of the town hall building has housed the Parmele Post Office since it was built.
Parmele had its greatest population growth in 1940 by reaching a high of 417. At the time Parmele was incorporated in 1893, the population is believed to have been the same as current times, a little less than 300. The population of Parmele based on the 2010 Census was 278.
Besides the Parmele-Eccleston Lumber Company, another sawmill was established in the town shortly after incorporation. The North State Lumber Company was established in 1895. Both lumber mills ceased operations between 1900 and 1910. However, during the time both mills were open, they carried a strong mercantile business through one or more commissaries located in Parmele at the time. In 1896, there were at least 10 general mercantile stores in Parmele. In 1899, the town also had several churches, the Odd Fellows Lodge, Temperance Club, a school house, and Dr. L. C. Ricks, a town doctor. In the early 1900's, there were also two hotels in Parmele: the Powell House and the Johnson House. These hotels primarily catered to railroad employees who required a lay over between their runs. A well-known lunchroom run by J.T. Stokes was also located near the railroad station for a number of years in the earlier part of the century. A devastating fire devastated the town on April 1, 1904 by destroying a large part of the business area along the railroad tracks. Parmele was also home to a bank for a number of years around the late 1910's and early 1920's. The J.C. Wynne Chevrolet Dealership was located in Parmele, as well, for a number of years before being relocated to nearby Bethel. Other businesses over the years included Lark Tillery Shoe Repair, Smith's Service Station, Jesse Laughinghouse Grocery, Will Carson's Filling Station, Johnnie Person's Place, Lizzie Perkins Club, Tom Clay's Club, and the continued beauty shop known as Maggie's Homeside Hair Trends and Diane's Beauty of Charm.
The first electricity lines in Martin County were said to have been installed in Parmele around the turn of the twentieth century. The early electricity current generated equipment in one of the lumber plants as well as some of the plant official's homes. By a special election on March 5, 1935, the entire town was furnished electric current by the Virginia Electric & Power Company.
The first brick school building in Martin County was built in Parmele around 1914 called the Parmele Training School. Its original name was the Parmele Industrial Institute, a private institution which was founded in 1912 by beloved professor William Claudius Chance, who was born in Parmele. The school was built using both Phelps-Stokes and Rosenwald funds in 1914 by the county board of education who assumed supervision of the former school. For several years, the Parmele Training School was the only school providing high school-level education to African American youth in the upper part of Martin County. This school was consolidated with East End High School in Robersonville in 1955 due to a fire. The first school in Parmele in the early 1900's was the Higgs Roanoke Seminary. Prior to 1912, W. C. Chance started the Higgs Industrial School. In 1910, Dr. Booker T. Washington visited Parmele.
Parmele has continued to be characterized as "God-Fearing" and "serious" about worship. Over the years, the town has been hope to 12 places of worship, which included the former congregations of The Northern and Southern Methodist Churches, The Parmele Presbyterian Church, Parmele Holiness Church (established before 1912), Jenkins Chapel Primitive Baptist Church, Glorious Hope United Holy Church, New Hope Fellowship Tabernacle Holiness Apostolic Faith Church; and the current places of worship which include Ridley's Chapel/Olive Branch Baptist Church (began as Ridley's Chapel in 1897 and changed to Olive Branch in 1993), Pegamos Pentecostal Church (now known as Soul Saving Station), Christian Chapel Holy Church of Power, Roberson Chapel Word of Life Ministries (formerly Roberson Chapel Church of Christ, Disciples of Christ), and True Heart Holiness.
Parmele is home to the Country music group "Parmalee". The band formed in Parmele in 2001 comprised of brothers Matt and Scott Thomas, their cousin Barry Knox, and their best friend Josh McSwain. They rehearsed in a little cement block barn in Parmele off North Main Street before moving onto the biggest stages in Country music. The band has many singles that have made it to the Top 40 on Billboard's Country Airplay chart.
While the commercial life of Parmele may have changed over the years, the town still continues to thrive. In recent years, revitalization has been a focus of town officials. In July 2018, the town received a $1.1 Million grant for a new and improved sewer system. In 2019, the town is building a new maintenance facility. Parmele is truly, "The Small Town That Makes a Difference!" For additional information: Visit Martin County and Town of Parmele.
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Calgary Public Library Turns a New Page with Cisco IP Communications
North America's sixth largest municipal library system improves customer service while reducing costs
CALGARY - November 16, 2005 - Canada's second largest public library system is improving customer service, reducing costs and positioning itself for future growth by adopting Cisco ® Internet Protocol (IP) Communications. The Calgary Public Library recently moved to an integrated voice, video and data network from Cisco Systems ® to link its 18 libraries across the city.
The end-to-end Cisco network was installed by NexInnovations, a Cisco Gold Certified Partner, and features wireless connectivity at all libraries. It supports 350 Cisco IP phones, 20 wireless Cisco IP phones, 350 Cisco Unity TM voicemail seats and Cisco IP Interactive Voice Response (IP IVR). The IP-based communications systems also allows the library to take advantage of the Alberta SuperNet -- a broadband network connecting facilities in 429 communities across the province - to connect the libraries and drive further savings.
"The Cisco IP Communications system will make a big difference to how we can service our customers," says Scott Stanley, information technology manager at the Calgary Public Library. "Something as simple as transferring calls between branches is a real bonus. Instead of telling our customers to hang up and call another number, we can now simply transfer them to the correct branch or department."
According to the Library, the Cisco IP Communications system is enabling a series of new services including online directories, four-digit dialing and branch-to-branch call transfer. Wireless IP phones will soon allow library staff to answer customer calls while performing their ongoing activities, a feature that will improve employee productivity and increase customer service. The integrated network is also lowering its total cost of ownership by eliminating redundant infrastructure, centralizing administration and simplifying maintenance.
"By migrating to a single, fully integrated, highly-secure communications infrastructure the Calgary Public Library is emerging as a 'best practice' for municipal library systems across North America," says Michel Houde, vice-president, national public sector at Cisco Systems Canada. "This is a great example of how municipal organizations across Alberta can take full advantage of Alberta SuperNet to save taxpayers money, enable new services and improve their organizational efficiency."
Wendy Lucas, Senior VP, Sales and Integrated Solutions, NexInnovations, explains the motivation behind the migration: "The Cisco IP Communications solution was attractive to the Library because it is fully redundant, standards-based and XML (extensible mark-up language) compliant. The system will be able to integrate with the new integrated library inventory tracking and customer database system, Dynix Horizon. This will help enable the library to develop an innovative self-service application that will be available from the browser of the Cisco IP phones."
Managing Growth, Reducing Costs
Over the past several years, the Calgary library system has grown exponentially, making it the second largest public library system in Canada and the sixth largest municipal library system in North America. The legacy phone systems, which included a 20-year-old private branch exchange in the central office and a mix of Centrex systems located in branch offices, was cumbersome to manage.
The Library was looking for a system that would help them control costs, provide the best service levels possible and future proof their communications. "We had to make a change, but we wanted to make a wise choice. One that would allow us to grow, leverage new applications and increase productivity while saving on costs," said Stanley.
According to Stanley, the system's performance and reliability are excellent. The Library's staff now is comfortable with the user-friendly system, is self-sufficient in terms of management and can resolve issues quickly and easily.
About the Calgary Library
With over 31 million customer interactions each year, the Calgary Public Library is one of the largest library systems in North America. It is also one of the most efficient, circulating materials for 22 percent less cost than the next most efficient major library system. Founded in 1911, the Calgary Public Library now features 18 branches serving over 900,000 Calgarians. Visit www.calgarypubliclibrary.com
About Cisco IP Communications
Cisco IP Communications is a comprehensive system of enterprise-class solutions including IP telephony, unified communications, rich media communications, including audio, web and videoconferencing, IP video broadcasting and customer contact solutions that take advantage of customers' existing Cisco IP infrastructure to deliver new converged applications. More information about Cisco IP Communications is available at: www.cisco.com/go/ipc.
About Cisco Systems
Cisco Systems, Inc. (NASDAQ: CSCO), the worldwide leader in networking for the Internet, this year celebrates 20 years of commitment to technology innovation, industry leadership and corporate social responsibility. Cisco Systems Canada Co., a wholly owned subsidiary of Cisco Systems, Inc., has offices across Canada dedicated to customer support, sales and service. In addition, Cisco has a significant research and development centre in Ottawa, Ontario. Information on Cisco can be found at http://www.cisco.com/ca. For ongoing news, please go to http://newsroom.cisco.com/canada/.
About NexInnovations Inc.
For over 25 years, NexInnovations has been providing technology consulting, infrastructure, deployment and support expertise to organizations across Canada. More than 3,000 business and government organizations, both local and national, rely on NexInnovations to help them plan, supply, integrate and support their IT systems from small custom orders to large complex projects. With approximately 1,200 employees in 30 office locations nationwide, NexInnovations ranks as one of Canada's largest privately held information technology companies. For more information about NexInnovations, please visit www.nexinnovations.com.
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Recent experimental research showing that the anesthetic and club drug ketamine can relieve depression quickly has intrigued a number of major pharmaceutical companies.
Recent experimental research showing that the anesthetic and club drug ketamine can relieve depression quickly has intrigued a number of major pharmaceutical companies. Depression, it goes without saying, affects huge numbers and a fundamentally new and effective pharmaceutical approach to treating the disorder hasn't emerged in decades.
The enthusiasm for ketamine is such that physicians, often working out of small clinics, have already started prescribing low doses of the generic anesthetic off-label for fast relief of le cafard—and drug companies are contemplating whether to get into the act by creating new drugs based on ketamine's biochemistry (Read part 1 and part 2).
A Johnson & Johnson subsidiary in Europe has gone as far as midstage clinical trials for a ketamine nasal spray. The trial there uses a slightly altered version of ketamine (esketamine, the "s" isomer for techies), which omits part of the molecule and leaves the most pharmacologically active portion in place, enabling less of the compound to be administered. "You can get away with a 30 to 40 percent lower dose," says Husseini Manji who leads neuroscience research at Johnson & Johnson.
The U.S. Food and Drug Administration has put Johnson & Johnson's version of esketamine on a fast track for approval, although, even if all goes well, patients may still have to wait a years to get a script. Esketamine, already used as an anesthetic in Europe, is not the only idea on the table. Ketamine appears to work (details still coming in from labs) by blocking a docking site, or receptor, on a neuron—in this case a spot where the essential signaling molecule glutamate attaches. The blockade triggers a complex chemical cascade that ends up restoring an impaired neuron's ability to communicate with other brain cells.
If that process is multiplied over millions of neurons in two critical brain regions—the hippocampus and the prefrontal cortex—drugmakers hope the blues will lift like a cloud. Johnson & Johnson is working on other projects that tap into ketamine research—one of which is looking at a wholly new drug that targets selected portions of this glutamate receptor in the hope of fine-tuning the antidepressant effects further. Other large pharmas, including AstraZeneca and Roche, are pursuing similar strategies.
If a formal FDA imprimatur is forthcoming, the issue of off-label prescribing may persist. One issue, which must be resolved through clinical trials rather than trial and error at ketamine clinics, is whether a spray works as well as intravenous infusions. The generic non-isomer form of ketamine is already used off-label as a nasal spray and not all reviews are positive. "It helped but not as much as the infusion," says Dennis Hartman, a patient with depression who sought help from ketamine-prescribing physicians, one of whom provided a spray.
A ketamine-like drug, if approved, will inevitably be more expensive than the generic anesthetic deployed in upstart depression clinics. Esketamine or one of its FDA-sanctioned cousins will probably be covered via a health insurance plan, but insurers' love of low-cost generics may mean that consideration could still be given to covering plain-vanilla ketamine, even if it hasn't run the clinical-trial gantlet. In fact, Carlos Zarate, a leading ketamine researcher who works at the National Institute of Mental Health, has even fielded calls from insurers wanting to know more about the generic drug to determine whether to put it on their formularies.
It is also still unclear whether the medical establishment, with a helping hand from law enforcement, may have to come to terms with what might be described as off–off-label prescribing—the depressed patient without insurance who learns about the possibility of a mood-altering quick fix and engages in the unsupervised self administration of Special K purchased in a club or on the street.
Hartman knows someone who went this route. "This personal friend received a ketamine infusion [from a physician]," Hartman says. "He achieved very strong relief, very similar to mine. After he relapsed, he went and sought this illegal form and he did not get the same effect." If Johnson & Johnson's esketamine trials result in a salable drug, the company has plans to safeguard it from those who want to divert it for recreational use.
What to do about ketamine is a question being posed everywhere, not just stateside. A New Zealand government official issued a report in July that instructed health boards throughout the country to scrutinize off-label prescribing more closely after a complaint lodged against a ketamine-supplying physician.
Inevitably, the grassroots appeal of an old drug with a new use that might provide hope for the deeply depressed is starting to generate its own social networks. As many as 20 physicians involved in prescribing ketamine interact on the Linked-In group called Ketamine for Psychiatry. Hartman is involved with setting up a new Web site, The Ketamine Advocacy Network, to foster activism among patients—another echo of medical marijuana's legacy.
The desperation to find new antidepressants means that ketamine will remain an object of fascination for mental health professionals and their patients. In the next five years, regulators and physicians are going to have to figure out how, if at all, the drug fits into the psychiatrist's pharmacopoeia. In the meantime, doctors and patients are increasingly adopting their own home-grown solutions.


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Also, ESPN this season ranked Seattle first among NFL teams in player suspensions for use of performance enhancing or other drugs. But it also doesn't mean the Eagles reached for players out of necessity. It's different when you actually see something awful, such as a football player punching a young woman.
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"I was scared to death. The rest, including almost 40 with connections to the state of Alabama, are left to wonder about their football futures. The defense, which struggled to stop the Bills run game, was called out by coach Todd Bowles during practice this week..
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London's Lord Mayor has come clean and announced his intention to stand as a Member of Parliament. Commentators have jumped on Boris Johnson's announcement as evidence that he covets the Prime Minister's crown, hardly a startling revelation. Cameron knows that Johnson would like his job one day which makes him far less dangerous to the PM than others close to him who clumsily mask that ambition. David Cameron's cool-headed response to Boris' declaration was to express delight at having his star player on the pitch. Cameron is no fool.


text:
In the sequel of `Sherlock Holmes` this time, Prof...
In the sequel of `Sherlock Holmes` this time, Professor James Moriarty (Jared Harris) is the most dangerous enemy. Moriarty is not the kind of person who is hesitant to remove the lives of many people in order to achieve his goals. Explosions in Strassbourg are one of the results of Prof. Moriarty's creation.
Holmes was nosy when his friend, Dr. Watson (Jude Law) was getting married, because the marriage would automatically make Holmes lose his partner in investigating the case.
A gypsy woman, Madam Sinza Heron (Naomi Repace), helped Holmes the adventure this time. There was also the Holmes brother, Mycroft Holmes (Stephen Fry) who came to be an accomplice of the detective this time.
Arguably, the visual effect of 'A Game of Shadow' is more stable than its predecessor. A few slow-movement scenes later find in the cease-fire. Colors are displayed also feels right.
Farce as those made by Holmes and several other characters in the film guaranteed to invite laughter. The chemistry between Robert Downey Jr. and Jude Law is not be doubted anymore. Since in the first film, the two men were able to captivate the audience and not be missed.
Chess compete between Holmes and Prof. Moriarty became the ultimate point. They both described the mind wanders respectively. Do you intrigued with the acting of the detective? The film 'Sherlock Holmes: A Game of Shadow' can be an alternative entertainment at this weekend.
What can we conclude of "A Game of Shadow"?
The chess competition showed mind wanders.
The visual effect of the movie is testable.
The movie is terribly out of standard.
The actors did not perform well.
The movie is worth watching.
Y. Yuli.Widya
Berdasarkan kalimat "The film 'Sherlock Holmes: A Game of Shadows' can be an alternative entertainment at this weekend" yang terdapat pada kalimat terakhir di paragraf terakhir, dapat diketahui bahwa film ini dapat menjadi alternatif hiburan di akhir pekan dan patut ditonton sehingga pilihan jawaban (E) adalah yang paling tepat. Pilihan jawaban (A) salah karena yang dimaksud sebagai mind wanders adalah Sherlock Holmes dan James Moriarty, bukan kompetisi ala 'bermain catur' yang mereka lakukan, (B), (C) dan (D) salah karena bertentangan dengan apa yang tersurat di dalam teks.
2012 film 2012 is Roland Emmerich's film which uses the Mayan calendar and other end-of-days prophecies for their doomsday scenario. It images the world coming to an end in 2012. 2012 film brings of...
My family of three went to see an early screening of the new Disney movie, "Brave" yesterday, so I thought I would write a quick "mommy" review of the movie. Disney definitely breaks the standard "Di...
The Character of Alice in TIm Burton's " Alice in Wonderland" was that
My family of three went to see an early screening of the new Disney movie, "Brave" yesterday, so I thought I would write a quick mommy" review of the movie. Disney definitely breaks the standard "Dis...
In the sequel of 'Sherlock Holmes' this time, Professor James Moriarty (Jared Harris) is the most dangerous enemy. Moriarty is not the kind of person who is hesitant to remove the life of many people ...


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The Demilitarized Zone between North and South Korea which hugs the 38th parallel is a place which former President Bill Clinton called the "most dangerous place on Earth." Created as a part of armistice negotiations in 1953, the two-kilometer wide DMZ is a stern reminder that North and South Korea are still technically at war and that the United States paid a heavy price to protect South Korea during the "Forgotten War" from 1950 until 1953.
In spite of all of this, there is one place where tourists can visit the DMZ and enter North Korea by crossing the Military Demarcation Line between North and South Korea: the UN-controlled Panmunjom complex, set up inside of the Joint Security Area. Straddling the 38th Parallel, this is the only chance most people will ever get to see North Korea from the free world.
I joined a USO-sponsored tour to the JSA five days after North Korea conducted their most recent missile launch (February, 2016) and present you this photo essay about the experience. USO runs the best tours and I highly recommend booking with them several weeks in advance if you are looking for a day trip during your next stay in Seoul. You can click here for more information.
After meeting our tour group a few minutes before 7:00AM at USO HQ, Camp Kim, in downtown Seoul, we hopped on a bus began the 90 minute bus ride to Camp Bonifas, located just inside the South Korean side of the DMZ. We were quickly asked to sign some paperwork that said we were entering an active war zone and were putting our lives at risk by continuing on the tour. After handing in those papers, our tour continued on a long stretch of highway towards the DMZ.
As we approached the checkpoint to enter the United Nations-controlled segment of the border, or bus swerved back and forth to avoid several barricades as raindrops slid down the bus windows. Once the bus came to a stop at a border checkpoint, an American soldier, Private Kennedy, boarded the bus and checked all of our passports before we could proceed to Camp Bonifas and UN Central Command inside of the DMZ. He would be our tour guide for the rest of the trip.
After we arrived at Camp Bonifas inside of the DMZ, Private Kennedy ushered the tour group into an auditorium to deliver a briefing about what we were going to see on today's tour. Aside from simple instructions about what to do and what not to do on the border (pointing, gesturing, taunting, and yelling were strictly prohibited), we were informed that because of escalated tensions on the border we would be unable to visit Dorason Observatory, a location which provides one of the best views of North Korea from South Korea.
We boarded our bus and began one of the most interesting rides of my life, down a narrow road towards our next location: Panmunjom, the famous blue buildings which straddle the 38th parallel and are in both North and South Korea. We were prohibited from taking photos on this stretch of the tour, but the wildlife and scenery inside the DMZ were out of this world.
White cranes, massive buzzards, and other rare birds were numerous in the rice paddies and barren hills and parched landscape which set between North and South Korea. The restricted nature of the DMZ has, ironically, turned it into one of the most ecologically diverse places on earth. Along with the wildlife, barbed wire fences, mine fields, and military outposts sat on top of various hills as clouds and mist obscured the distant landscape. Rice paddies and rusting vehicles were also visible off in the distance.
After a short briefing, Private Kennedy informed us that the Korean soldiers were real and we were not to touch them or get within six inches of them. He then let us know that anyone who stood to the soldier's right was in South Korea and anyone who stood to the soldier's left was in North Korea, just past the 38th parallel. The picture that follows was taken from the North Korean side and shows the 38th parallel in the middle. The sand is North Korea and the gravel is South Korea.
Inside of the conference room, a soldier stands at the ready with his back to North Korea, preventing any tourists from either being abducted or choosing to defect to the Communist North.
Outside, things were just as tense but in a more visible way. A North Korean soldier appeared several moments after our group re-emerged from the conference rooms. As we positioned our cameras, he played a game with us, ducking in front of and behind the pillars on the North Korean border facility. He kept a vigilant watch during this act.
His appearance stood in stark contrast to the South Korean guards on our side of the border. The imposing concrete facade of the North Korean side provided a backdrop which perfectly illustrates the differences which keep Korea divided to this day.
Our tour then continued to some other spots inside of the JSA. We stopped by JSA tower to take in another stunning view of North Korea from a military observation point very near the location of the famous axe murders and the Bridge of No Return. As the weather began to clear, more of North Korea's bare hills were visible, but we could not see the famous flagpole bearing a 600 pound North Korean flag. Because the North cleared out all trees to prevent defections several years ago, it is very easy to see where the border lies in the distance. The clouds were eerily representative of the mysterious nature of North Korea to the outside world.
The Bridge of No Return was a location where POWs chose between the North and South following the armistice and where several prisoner exchanges have taken place since 1953. President Clinton visited the bridge and attempted to walk on it, resulting in its subsequent closure to tourist groups.
North Korea beckons across the Bridge of No Return.
The Bridge of no return is seen in the last part of the photo, with North Korea in the background. The foreground is part of a footpath to our outlook point.
After a few more minutes on the bus and a stop at the JSA gift shop, our tour with Pvt. Kennedy was over and we were on our way out of the DMZ to stop at one of the famed infiltration tunnels leading from North to South Korea. I could not take any photos there because of the nature of that tour, but some Korean soldiers left their helmets on a table during our lunch break to close out the tour.
As an American with an interest in the Korean War and military history, the DMZ was always one of my top travel goals when I moved to Japan several years ago. I am very happy I got to visit during a time with such high tension and recommend everyone visit before the DMZ is either closed to tourists or ceases to exist. This is truly the last vestige of the Cold War left on earth.
All of us have favorite places on the planet. My hometown is a nostalgic place. Philadelphia and Tokyo always hold a special place in my heart because I studied in both of those cities. With travel and historical knowledge, I have come to love places like Macau, Rangoon, and Hong Kong.
One place I had visited and liked, but not loved, was Seoul, South Korea. I had been there several times but never had the one experience for which everyone lusts when they go to a new place while traveling. Whether it is meeting new friends, having an amazing meal, or just having a great night out on the town, we need an experience to solidify our love for a city when we travel. During my most recent trip to Seoul, I had that experience.
During our second night out in the city, my friend and I decided that we would head out in the early darkness to take some photography of the masses in famous spots like Hongdae and Myongdong. Our accommodation was located right in the heart of Hongdae, so we headed out to do some people watching as the sun began to set on this balmy June evening. People of all ages were out and about chatting, playing, and enjoying the evening.
From there, were off into the Hongdae night, not knowing what to expect nor what waited for us.
For those of you who have never been to the Hongdae area, it is quite a happening place at night. Situated next to Hongik University, lots of young Seoulites, Westerners, and tourists pack the area for some of the best nightlife in all of Asia. Nightclubs, bars, restaurants, and a lively street music scene make this quite the happening place.
Further down the main street, shops are filled with patrons as the streets teem with people heading to their destination for the evening. The glistening lights, talking masses, and smell of grilling food make for a unique atmosphere.
As we approached the famous jaywalking intersection– where Koreans and visitors alike disregard crosswalks and cross at will– an interesting tune came to our ears. A younger man was singing in English and in Korean so we approached the growing crowd to have a listen. Sure enough, he knew how to handle a crowd. His band filled the evening with some great scores and kept the Korean crowd engaged and excited in between each one of his songs. Then, suddenly, he stopped singing and called my friend and I into the middle of the circle. He wanted to talk to us and translate for the Korean onlookers. After a while he asked us about from where we had come.
When I responded that I was from Pennsylvania, things got very interesting. As it turns out, he went to high school at a place called Lower Dauphin, about 40 minutes north of my hometown. They were in the same athletic conference as my hometown high school so we had an instant connection. As he explained to the Korean crowd how close our hometowns were, he decided to sing us a tribute song, wishing us well on our journey and travel in Korea. These types of moments when you travel are what make you never forget a place. Please watch some of the video as he took my phone and sang for us and then got the Korean crowd involved, chanting the chorus and wishing us well for the remainder of our stay in Seoul.
As soon as he struck his first chord, the crowd came alive and sang along with him, much to my delight. He sang and they chanted with him in a booming voice. The energy continued to build as they sang for three minutes to wish us well on our journey.
Certain nights or events in our life create opinions and strong feelings for people, places, or things. This song and the openness of the Korean people certainly changed my opinions surrounding Seoul. This was the night I fell in love with Seoul. I need to come back again to truly develop an appreciation and understanding of the city and its complexities.
I have only ever felt this way about one other city in Asia, Tokyo, and I have been living in Japan and making frequent trips to Tokyo for the last two years.


text:
Flash flooding in Wisconsin, Minnesota results in mudslides, washed out roads and water rescues
Pam Wright
Thu, 11 Aug 2016 18:29 UTC
© Wisconsin Department of Transportations
Flooded roadways in the town of Cream, Wisconsin.
Flash flooding in parts of Wisconsin and Minnesota washed out roads, caused mudslides and prompted several water rescues after more than seven inches of rain fell in some areas Thursday.
Motorists were stranded in the floods, and there were also reports of basement collapses in the Minnesota towns of Willmar and Olivia, according to the Associated Press.
"If you talk to the experienced, or old-timers here, nobody's ever seen it rain quite like this in that short of time," Willmar Public Works director Sean Christensen told the AP.
Willmar residents were asked to stay home Thursday due to the flooding, and because the city's wastewater treatment plant was overwhelmed, residents were asked to limit their water use until further notice, the AP also reported.
"I'm afraid people were praying for a little bit of rain too much and it all got here all of a sudden," Christensen told the AP.
In Gilmanton, Wisconsin, water rescues were performed after rising waters flooded homes along a creek, Bill Graul of WKBT-TV reported.
According to the National Weather Service, there were reports of mudslides and landslides near the border of Wisconsin and Minnesota, where floodwaters have undermined several roads. Floodwaters also washed out some bridges, and in northern Buffalo County, Wisconsin, highways 37 and 88 were closed.
Travel advisories have been issued by the NWS-La Crosse, particularly in Wabasha, Trempealeau, and Buffalo counties, where many rural roads were washed out.
States of emergency were declared in Buffalo and Trempealeau counties due to the flooding, the AP also said. In Independence, some homes and businesses were voluntarily evacuated as the water rose, the report added.
We've seen mudslides, tree damage near Wabasha & Elba. Please drive with caution. Here's Hwy 61 south of Lake City pic.twitter.com/ly1HpuElvp
— MnDOT District 6 (@mndotsoutheast) August 11, 2016
In Trempealeau County, Highway 93 dropped more than a foot in the northwestern part of the county after flooding washed out a culvert, NWS-La Crosse also reported.
© WisDOT
Culvert washout on WIS 88 (Buffalo County)
Culvert washout on WIS 88 (Buffalo County) north of County U, south of Gilmanton. Crews are out assessing damage. pic.twitter.com/GIhRJoXQXU
— WisDOT NW Region (@WisDOTnorthwest) August 11, 2016
In Minnesota, the Department of Transportation reported mudslides and tree damage near Wabasha and Elba.


text:
package org.jetbrains.idea.maven.utils;

import com.intellij.application.options.PathMacrosImpl;
import com.intellij.ide.ApplicationInitializedListener;
import com.intellij.openapi.application.PathMacros;
import com.intellij.openapi.util.io.FileUtil;

public class MavenEnvironmentRegistrar implements ApplicationInitializedListener {
  @Override
  public void componentsInitialized() {
    registerPathVariable();
  }

  private static void registerPathVariable() {
    String repository = MavenUtil.resolveLocalRepository(null, null, null).getAbsolutePath();
    PathMacros macros = PathMacros.getInstance();

    for (String each : macros.getAllMacroNames()) {
      String path = macros.getValue(each);
      if (path != null && FileUtil.pathsEqual(repository, path)) {
        return;
      }
    }

    macros.setMacro(PathMacrosImpl.MAVEN_REPOSITORY, repository);
  }
}

redpajama_set_name: RedPajamaGithub


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text:
Q: call to another function in a dll causes access violation okay so I'm starting to realize that dll arn't the simplest of things to understand, I'm trying to make a dll which is VC6 compatible, I got some code working in VS2010 but in trying to work out how to get that code to work for a VC6 project I've found the following issue:
My call to the dll looks like this
MyDll::connect();

when i try and run a program which uses this function, it starts out fine but as soon as it gets to a function call i.e.
VOID connect()
{
hello();    //0xC0000005: access violation
}

VOID hello()
{
    int i = 1;
}

the disassembly looks like this:
->  00000000   ???
    00000001   ???
    00000002   ???
    00000003   ???
    00000004   ???
    00000005   ???
    00000006   ???
    00000007   ???
    00000008   ???
    00000009   ???
    etc...

A: you didn't exported the function .....a program is not permitted to access a function in a dll unless that function is registered as exported function.
to do that you should prototype it like this
to export a function inside a class this function should
1- be public member.
2- be a static member
class MyDll{
   public:
   static void connect();
}
//then redeclare it like this
#ifdef _cplusplus
extern "C"{
#endif
__declspec(dllexport) void  MyDll::connect(){
//TODO
}
#ifdef _cplusplus
}
#endif

do this for any class member function you want to export
this is an example
Creating a simple Dynamic Link Library example

redpajama_set_name: RedPajamaStackExchange