text:
The Promising Future of Stem Cell-Based Therapy for Kidney Diseases
Chee-Yin Wong, Faculty of Medicine and Health Sciences, University Tunku Abdul Rahman
Kidney disease is a prevalent global health problem. Stem cells are an attractive candidate as a form of regenerative medicine for kidney diseases. There have been increasing scientific evidences demonstrating the roles of stem cells in minimising damage while improving the function of kidney.
Kidney disease is a prevalent global health problem. According to the World Health Organization, as many as five to ten million people die annually from kidney diseases worldwide. Chronic kidney disease (CKD) is projected to be the fifth leading cause of death worldwide by 2040.
To date, the current available drugs or treatments can only delay the progression of the kidney disease yet cannot reverse the progression into the end-stage kidney disease. There has been no significant breakthrough in the medical treatment of kidney diseases. The current therapeutic choices to prolong the lifespan of patients with end-stage kidney disease are limited to kidney replacement therapies, such as dialysis and organ transplantation. Due to the high medical cost involved in dialysis therapy, it is is not an ideal solution because it fails to restore or substitute all kidney functions while also compromising the patients' quality of life. Meanwhile, the severe shortage of organ donors and the risk of potential organ rejection limit the practice of kidney transplantations. Therefore, researchers should consider focusing on exploring innovative therapies that can improve the quality of life for people living with kidney illnesses.
Stem cells are cells that can self-renew and can transform into a variety of cell types. Moreover, stem cells can be easily expanded in vitro. Stem cells have been widely studied under in vitro, in vivo and clinical trial settings to treat many diseases including cardiac, neurological, vascular, immunological, and kidney diseases. This form of intervention can pave the way as the next regenerative medicine for human diseases.
Embryonic stem cells (ESCs) are pluripotent cells with unlimited differentiation potentials whereby one ESC can transform into a whole body cell type, including kidney cells. With the unique power of this type of cell, several research groups have demonstrated that mouse ESCs can integrate into kidney compartments suggesting the potential value of stem cells for kidney repair. To bring this idea further, researchers are working on generating the whole kidney structure from ESCs, termed as organoids.
However, despite its clinical potentials, the use of ESCs for regenerative medicine is compounded by the risks of tumour formation and the ethical concerns on the source of ESCs in the first place. ESCs are primarily made from cells found in a human blastula, one of the earliest stages of human life. There are views that destroying a blastula for its cells is akin to destroying an unborn child.
Induced pluripotent stem cells
Induced pluripotent stem cells (iPSCs) share many regenerative properties as ESCs. This was a breakthrough finding that became a landmark in stem cell research. The development of iPSCsbased therapies could overcome the specific issues related to the use of ESCs, such as ethical concerns due to the cells' source and the risks of cell rejection by the recipient patient. The potential of iPSCs in kidney regeneration have been explored, including establishing unique methods to stimulate human iPSCs to differentiate into kidney cells or three-dimensional structures of the kidney.
Mesenchymal stem cells
Mesenchymal stem cells (MSCs) were first found in bone marrow. Over the years, researchers have found that MSCs can be isolated from various organs or tissues. These stem cells have been demonstrated on their ability to differentiate into three lineages such as ectoderm, mesoderm and endoderm.
In the field of kidney disease, MSCs are among the most efficient type of cell population for activating regeneration in a damaged kidney. MSCs have demonstrated their ability to transform into renal components cell in vitro. When MSCs were injected into an animal with kidney disease, results showed that it can reduce further kidney damage. MSCs have three unique properties that enhance its potential in regenerative medicine. Firstly, MSCs have homing effect whereby after MSCs are injected into the body of an animal, the cells can migrate to the injury site. Secondly, MSCs have immunomodulation ability to decrease the inflammation at injury site which can reduce further damage. Thirdly, MSCs do not trigger immune response when transplanted to the recipient, which eliminates the risk of cell rejection by the recipient.
From commercial point of view, MSCs are a good cellular candidate to use under commercial setting because MSCs can be easily obtained from various organs or tissues and then grown into hundred- or thousand-times therapeutic dosage, and can be transplanted between individual humans i.e., allogeneically. Based on these many positive points, MSCs have become the main choice of stem cell in human translation research for regenerative medicine purposes.
Clinical trials of stem cells for kidney disease
Until March 2021, there are more than 40 clinical trials involving the use of stem cell-based therapy (mainly MSC) in the treatment of kidney diseases, either on-going or completed, registered in the U.S. National Library of Medicine.
The first few trials using MSCs from different tissue sources (bone marrow, adipose, umbilical cord, etc.), either autologously or allogeneically, suggested that these cells can be given safely to humans. In one study, few patients who had a high risk of post-operative AKI, underwent cardiac surgery, while concurrently received allogeneic MSCs. The patients had a shorter hospital stay and did not need readmission. In addition, this study concluded that the MSC infusion was safe and well-tolerated.
There are many human trials that use MSCs to treat CKD. A few pilot studies, assessing the safety and clinical feasibility of administration of MSCs for patients with CKD, reported that the cells were safe and did not result in any adverse effects. At the same time, improvement in kidney function was observed.
Currently, many clinical trials are still on-going and will provide more insights into and possibly further support these achievements with cellbased therapy for kidney diseases.
Stem cell-derived extracellular vesicles
Other from stem cells-based therapy, researchers are exploring the usage of stem cell-derived extracellular vesicles. Extracellular vesicles (EVs) are small membrane vesicles secreted by various cells and found in most body fluids. The benefits of using EVs, as demonstrated by the researchers, are preventing tissue injury, reducing inflammation, inhibiting programmed cell death, and inducing cell cycle re-entry of resident cells, leading to cell proliferation, tissue self-repair and regeneration.
There are several advantages of using stem cell-derived EVs in clinical applications including avoiding most of the safety issues associated with stem cell treatment, i.e. cellular contamination with oncogenic cells and tumorigenicity. Furthermore, EVs offer a wide variety of possible modifications to the carrier molecules for the purpose of improving the distribution and desired effects.
Several studies show that intravenous MSC-derived EVs reduce cell damage and programmed cell death in the kidneys while enhancing the proliferation of the renal cells, resulting in improved kidney function. When EVs were administered in animal models with AKI and CKD, the animals experienced a reduction in kidney injury suggesting that the risks of cellular rejection is remarkably decreased.
Research on exploring stem cell-based therapies for kidney regeneration has shown promising results from in vitro and in vivo studies, and a well-accepted safety profile from early-phased human clinical trials. However, it will take some time before stem cell-based therapies become more significant proof of clinical efficacy for kidney diseases. Follow-up data from longer term is crucial to understand the potential long terms side effects of stem cell therapies on kidney diseases, especially to address the concerns on the use of live stem cells. More research can be done to evaluate EVs as a possible alternative to live stem cells especially as stem cells-derived EVs that can mimic its parental cells' effects in protecting the kidneys. A great future in the field of regenerative medicine is in store for stem cell therapy especially with regards to kidney regeneration.
1. Luyckx, V.A., M. Tonelli, and J.W. Stanifer, The global burden of kidney disease and the sustainable development goals. Bull World Health Organ, 2018. 96(6): p. 414-422D.
2. Luyckx, V.A., et al., Sustainable Development Goals relevant to kidney health: an update on progress. Nat Rev Nephrol, 2021. 17(1): p. 15-32.
3. Liyanage, T., et al., Worldwide access to treatment for end-stage kidney disease: a systematic review. Lancet, 2015. 385(9981): p. 1975-82.
4. Vanholder, R., et al., Cost of renal replacement: how to help as many as possible while keeping expenses reasonable? Nephrol Dial Transplant, 2016. 31(8): p. 1251-61.
5. Saidi, R.F. and S.K. Hejazii Kenari, Challenges of organ shortage for transplantation: solutions and opportunities. Int J Organ Transplant Med, 2014. 5(3): p. 87-96.
6. Wong, C.Y., Current advances of stem cell-based therapy for kidney diseases. World J Stem Cells, 2021. 13(7): p. 914-933.
7. Rodríguez-Fuentes, D.E., et al., Mesenchymal Stem Cells Current Clinical Applications: A Systematic Review. Arch Med Res, 2021. 52(1): p. 93-101.
8. Geuens, T., C.A. van Blitterswijk, and V.L.S. LaPointe, Overcoming kidney organoid challenges for regenerative medicine. NPJ Regen Med, 2020. 5: p. 8.
9. Araoka, T., et al., Efficient and rapid induction of human iPSCs/ESCs into nephrogenic intermediate mesoderm using small molecule-based differentiation methods. PLoS One, 2014. 9(1): p. e84881.
10. Taguchi, A., et al., Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. Cell Stem Cell, 2014. 14(1): p. 53-67.
11. Ullah, I., R.B. Subbarao, and G.J. Rho, Human mesenchymal stem cells - current trends and future prospective. Biosci Rep, 2015. 35(2).
12. Rota, C., M. Morigi, and B. Imberti, Stem Cell Therapies in Kidney Diseases: Progress and Challenges. Int J Mol Sci, 2019. 20(11).
13. Westenfelder, C. and F.E. Togel, Protective actions of administered mesenchymal stem cells in acute kidney injury: relevance to clinical trials. Kidney Int Suppl (2011), 2011. 1(3): p. 103-106.
14. Makhlough, A., et al., Bone marrow-mesenchymal stromal cell infusion in patients with chronic kidney disease: A safety study with 18 months of follow-up. Cytotherapy, 2018. 20(5): p. 660-669.
15. Villanueva, S., et al., Adipose tissue-derived mesenchymal stromal cells for treating chronic kidney disease: A pilot study assessing safety and clinical feasibility. Kidney Res Clin Pract, 2019. 38(2): p. 176-185.
16. Tang, T.T., et al., Extracellular Vesicles: Opportunities and Challenges for the Treatment of Renal Diseases. Front Physiol, 2019. 10: p. 226.
17. Biancone, L., et al., Therapeutic potential of mesenchymal stem cell-derived microvesicles. Nephrol Dial Transplant, 2012. 27(8): p. 3037-42.
18. Vizoso, F.J., et al., Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine. Int J Mol Sci, 2017. 18(9).
19. Park, K.S., et al., Enhancement of therapeutic potential of mesenchymal stem cell-derived extracellular vesicles. Stem Cell Res Ther, 2019. 10(1): p. 288.
20. Grange, C., et al., Stem Cell-Derived Extracellular Vesicles and Kidney Regeneration. Cells, 2019. 8(10).
21. Wu, X., et al., Micro-vesicles derived from human Wharton's Jelly mesenchymal stromal cells mitigate renal ischemia-reperfusion injury in rats after cardiac death renal transplantation. J Cell Biochem, 2018. 119(2): p. 1879-1888.
--Issue 45--
Wong Chee Yin is affiliated with University Tunku Abdul Rahman, Malaysia. With his vast experience of 20 years in stem cells research, he has published many related articles covering from lab-based to clinical translation studies.


text:
'use strict';

var validator = require('validator');
var React = require('react');
var ReactBootstrap = require('react-bootstrap');
var Grid = ReactBootstrap.Grid;
var Row = ReactBootstrap.Row;
var Col = ReactBootstrap.Col;
var Panel = ReactBootstrap.Panel;
var Alert = ReactBootstrap.Alert;
var Button = ReactBootstrap.Button;
var Input = ReactBootstrap.Input;
var DropdownButton = ReactBootstrap.DropdownButton;
var MenuItem = ReactBootstrap.MenuItem;

var DeskPageFrameActions = require('../../action/desk/DeskPageFrameActions.js');
var AceEditor = require('../element/AceEditor.js');
var WizardVariantName = require('../wizard/WizardVariantName.js');
var FormPropsComponentEditorActions = require('../../action/form/FormPropsComponentEditorActions.js');
var FormPropsComponentEditorStore = require('../../store/form/FormPropsComponentEditorStore.js');

var FormPropsComponentEditor = React.createClass({

    _handleCreateVariantName: function (e) {
        e.stopPropagation();
        e.preventDefault();
        FormPropsComponentEditorActions.startWizardSaveVariant({
            propsScript: this.getPropsScript()
        });
    },

    getInitialState: function () {
        return {
            wizard: FormPropsComponentEditorStore.initialModel.wizard,
            propsScript: this.props.propsScript
        };
    },

    componentWillReceiveProps: function(nextProps) {
        this.setState({
            propsScript: nextProps.propsScript
        });
    },

    onModelChange: function (model) {
        this.setState(model);
    },

    componentDidMount: function () {
        this.unsubscribe = FormPropsComponentEditorStore.listen(this.onModelChange);
    },

    componentWillUnmount: function () {
        this.unsubscribe();

    },

    render: function(){

        var editorElement = null;
        var toolBarElement = null;

        if (this.state.wizard === 'SaveVariant') {

            toolBarElement = (
                <Row style={{marginBottom: '3px'}}>
                    <Col xs={12}>

                    </Col>
                </Row>
            );
            editorElement = (
                <WizardVariantName
                    componentName={this.props.componentName}
                    selectedUmyId={this.props.selectedUmyId}
                    style={this.props.editorStyle}
                    propsScript={this.state.propsScript} />
            );

        } else {
            toolBarElement = (
                <Row style={{marginBottom: '3px'}}>
                    <Col xs={12}>

                                        <button className="btn btn-default btn-xs dropdown-toggle" type="button"
                                                id="dropdownMenu" data-toggle="dropdown" aria-expanded="true">

                                        </button>

                                                    Save as new variant for component

                                        {/*{todo - variant name}*/}

                    </Col>
                </Row>
            );
            editorElement = (
                <AceEditor ref='editor'
                           sourceName='componentPropsScript'
                           style={this.props.editorStyle}
                           sourceCode={this.state.propsScript}/>
            );
        }
        return (
            <Grid style={this.props.style} fluent={true}>
                {toolBarElement}
                <Row>
                    <Col xs={12}>
                        {editorElement}
                    </Col>
                </Row>
            </Grid>
        );

    },

    getPropsScript: function(){
        return this.refs.editor.getSourceCode();
    }

});

module.exports = FormPropsComponentEditor;

redpajama_set_name: RedPajamaGithub


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For many of us, in spite of the fact that we enjoy our jobs, if we could work less we would choose to do so. Why? Because the other parts of our lives are so much better. Unfortunately, we all need money to survive, so that means we have to go out and graft. However, have you ever stopped to consider the ways in which you can do less with your life and still enjoy it? This article aims to take a closer look at some strategies.
Why strive to work less in the first place?
It seems a little backwards to decide to work less, doesn't it? Most of the time we try to maximise our earnings, because that means we can afford houses, and holidays and nice cars. We can drink better wine, wear nicer clothes, perhaps even pay someone to come and do our cleaning. But becoming better off financially, often leaves us time poor. Why work to earn more and more money, if you then have to outsource your chores, and you have less time to enjoy it. If you spend the two weeks' holiday you've worked hard to pay for, asleep on a lounger, isn't that a little bit of a waste of money?
If this is how you measure success, then fair enough. Many people are praised for earning lots of money, and becoming celebrities in certain circles. But for others of us, doing the washing up, digging up weeds, listening to the washing machine thrum, these are all moments that ground us deeply in our reality and remind us to be grateful for what we have and who we are.
Earning more means being busy, and if this is not for you, here's some way to rein in abundance and live within your means. You can do less, and have less, and still be happy.
What can you live on? How much income do you realistically need? Once you know that, work within your budget. How much helps you feel comfortable and fulfilled? Understanding exactly the amount is useful, as it means all your money-related decisions can reflect this.
Which of your expenses don't you need?
If you go through your bank records periodically, you're bound to find payments that are a waste of time. We all pick subscriptions and standing orders up for things we rarely use. Cut out the expensive gym membership if you never go. If you feel you need to exercise, switch to exercising in the park, jogging around the streets, or walking in the countryside. It's free and it's better for you! Get rid of the house phone if you only use mobiles. Do you really need that box delivered every month? Cut back, and cut out.
For many of us, spending money on ourselves helps to validate our feelings. We comfort buy, the way some people comfort eat. This may manifest itself by hours spent on auction sites, or you may be someone who spends a fortune in bookshops. If you know why you're spending money, now is the time to do something about it. Who needs a wardrobe of clothes you never wear? Are you feeling lonely? Or sad? Do you lack a purpose in life? Far better to identify the reasons you do what you do, and change your habits. You could save a fortune and be far happier to boot!
If you spend a lot of money on other people, it may be because you are trying to impress them or show them you care. The thing is, you can be generous in other ways, it doesn't have to be financial. Thoughtful gestures mean so much more. Spend time with people. Help them out with their own chores. Make cards, gifts, cakes or puddings. Hugs cost nothing and they genuinely boost your mood, so give it a try.
Try decluttering. It's something that many people are having a go at currently, so there are lots of books and articles you can read. There's a whole psychology around the fact that we feel better if we have less clutter, and that once we realise life isn't about having stuff, we're able to let go of it. A decluttered environment is said to leave you feeling free, without stress. You have more room in your life for relaxation, you have more money, or at least less debt. If you're up for decluttering you can either try and sell your items – there might be a lot of work involved, or cut your losses and take them to a charity shop.
Hand in hand with having less stuff, is consuming less. Once you've decluttered, you don't want to buy it all back again. Consider the resources you buy and how much you waste. Food, clothes, furniture, toys, books, games, newspapers, toiletries. Focus on what you have. Enjoy it. Be content.
Consider your workload, and your other commitments. Is your to-do list too long? How much of it can you drop or say no to? It doesn't have to be all at once, but ideally it's time to lose some of the things that clog up your energy and your time. Make more time, to do less.
If you let it, social media and the things you do online, can rule your life. Cut back. Even if you cannot let go completely, have periods of time where you are not connected. Enjoy the silence.
Once you have fewer distractions, you can spend more time either with people you love, or doing the things you love. Cut things out from your life, to make room for the things you truly love.
It sounds straightforward, but of course it really isn't. The aim is to do and have less but enjoy life more, and you have to keep trying, and keep peeling back the layers of your life, until eventually, what you have left is the most beautiful, the most essential.


text:
Sony BMG has pissed off Texas
State of Texas is suing Sony BMG over the rootkits.
The state sued Sony BMG Music Entertainment on Monday under its new anti-spyware law, saying anti-piracy technology the company slipped into music CDs leaves computers vulnerable to hackers.
The lawsuit is over the so-called XCP technology that Sony had added to more than 50 CDs to restrict to three the number of times a single disc could be copied.
(Thanks Lior)

redpajama_set_name: RedPajamaCommonCrawl


text:
TV – Series
TV Movie Movies
Back in Louisiana for Christmas, Noelle Collins (Mitchell) has big plans to resurrect the town's live nativity, a beloved tradition that her late mother used to put on. Things become…
Genre: Romance, TV Movie
Kill Me Twice
A woman stages her own suicide but still lives in fear of her abusive ex-boyfriend tracking her down and stealing the son he never knew he had.
Genre: Drama, Thriller, TV Movie
Eve is a Christmas movie fanatic and dreams of having a movie-perfect Christmas with a movie-perfect boyfriend. On Christmas Eve, when Eve and her cynical sister Lacy make wishes to…
Genre: Fantasy, Romance, TV Movie
Corey Calvin lives in a ski village where she works at her late father's local antique shop, having sidelined her her big city dreams of becoming a theater director. When…
Genre: Drama, TV Movie
Two rival musicians, Lindsay and Wes who perform in a dueling piano show, suddenly find themselves without a gig on Christmas Eve and decide to road trip to their neighboring…
Single mom Abbey takes a leap of faith to pursue her passion for interior design. When she gets hired to decorate the estate of local businessman Nick, Abbey must complete…
Christmas Cupcakes
When their family bakery may have to close its doors right before Christmas, rival sisters Kim and Gina must team up in a national baking competition to win the grand…
Jenna and Charlie found love in Ireland but their dreams drove them apart. Five years later, they reunite and Jenna has to decide where her heart belongs—back home or in…
A family on a camping trip to Big Rock National Park, about 20 miles from where Fallen Kingdom has ended, take part in the first major confrontation between dinosaurs and…
Genre: Action, Adventure, Science Fiction, TV Movie
Two years after the events of "Change Your Mind", Steven (now 16 years old) and his friends are ready to enjoy the rest of their lives peacefully. However, all of…
Genre: Adventure, Animation, Comedy, Family, Music, TV Movie
ZIM discovers his almighty leaders never had any intention of coming to Earth and he loses confidence in himself for the first time in his life, which is the big…
Country: South Korea, USA
Genre: Animation, Comedy, Family, Science Fiction, TV Movie
Rocko's Modern Life: Static Cling
After 20 years in space, Rocko returns to a technologically advanced O-Town and makes it his mission to get his favorite show back on the air.
Genre: Animation, Comedy, TV Movie
Aziz Ansari: Right Now
Genre: Comedy, Documentary, TV Movie
A Scottish chaplain embarks on an epic journey through space. Based on Michel Faber's 'The Book Of Strange New Things'.
Genre: Drama, Science Fiction, TV Movie
A cute college professor teaching "Who Dunnit" fiction gets involved in the police investigation of the theft of a mega dollar research plant, the death of a student, disappearance of…
Genre: Crime, Mystery, TV Movie
Paris, Wine & Romance
Isabella is the ambitious new owner of her family's Oregon winery whose dream of becoming world-renowned takes a big step forward when she enters a prestigious wine competition in Paris….
Love in the Sun
When successful dating app creator Alana hesitantly gets engaged, she returns to her hometown in Florida to deliver the news to her dad. Upon returning home, she crosses paths with…
Sailing Into Love
A biology teacher's crusade to save a nearby island from development leads to unexpected romance with the handsome and mysterious young sea captain who is new to the seaside town…
Chronicle Mysteries: Vines that Bind
Alex and 2 colleagues investigate a 1 year old, suspicious CO2 death at a vineyard, of the founder. His 2 sons inherited his 60% share. But a newly found, unsigned…
Deadwood: The Movie
Follow the 10-year reunion of the Deadwood camp to celebrate South Dakota's statehood. Former rivalries are reignited, alliances are tested and old wounds are reopened, as all are left to…
Genre: TV Movie, Western
Busy chocolatier Charlotte has left her boyfriend James at the altar three times and now she needs to prove to him that she really does want to marry him. Things…
Love Takes Flight
Dr. Lizzie Beauman (DeLoach) is a single mother and hospital administrator determined to improve the hospital's conditions while also caring for her young daughter, Quinn. Lizzie is very type-A; organized…
Season for Love
When a talented chef returns to her Texas hometown, she winds up entering the town's famous BBQ cook off and gets more than she bargained for when the surprise judge…
Genre: Drama, Romance, TV Movie
Who's Watching Oliver
Who's watching Oliver tells the story of a mentally unstable loner lost in a life forced upon him. By night Oliver aimlessly wanders the streets and bars on what can…
Country: Thailand, USA
Genre: Horror, TV Movie
True Love Blooms
Spring is in full bloom when urban gardener Vicki fights to save her community garden from a handsome real estate developer. Both are caught off guard when it's not just…
Bottled with Love
After being stood up, Abbey gets inspired to open her heart in a letter, put it in a bottle and toss it out to sea. Months later, a man fishing…
Love to the Rescue
Two single parents come head to head when their kids want to adopt the same dog. Agreeing to co-foster, free-spirited Kate and type-A Eric must work together to find the…
Small town bookstore owner Jamie Vaughn learns that hers and other struggling local businesses face closure by a powerful Portland property developer, led by architect and former flame Sawyer O'Dell….
Ken Jeong: You Complete Me, Ho
In his first-ever stand-up special, Ken Jeong shares hilarious stories from his Hollywood career — and reveals how "The Hangover" saved his life.
Genre: Comedy, TV Movie
Ray Romano: Right Here, Around the Corner
Ray Romano cut his stand-up teeth at the Comedy Cellar in New York. Now, in his first comedy special in 23 years, he returns to where it all began.
The story of several friends in New York City facing financial poverty, homophobia, AIDS, and, of course, rent.
Genre: Drama, Music, TV Movie
The Night Stalker
Wisecracking reporter Carl Kolchak investigates a string of gruesome murders in Las Vegas. It seems that each victim has been bitten in the neck and drained of all their blood….
Genre: Horror, Mystery, Thriller, TV Movie
Agatha and the Truth of Murder
In 1926, with her personal life in tatters and her writing in crisis, a young Agatha Christie decides to solve a real-life murder.
Genre: Mystery, TV Movie
A Midnight Kiss
With only one week to prepare, Lisa Patterson and her family of party planners are given the biggest job in their company's history: a New Year's Eve party for tech…
MARS: Inside SpaceX
The inside story of SpaceX's plan to get humanity to Mars, providing an unprecedented glimpse into one of the world's most revolutionary companies. A behind-the-scenes journey with Elon Musk and…
Genre: Documentary, History, TV Movie
Brexit: The Uncivil War
Political strategist Dominic Cummings leads a popular but controversial campaign to convince British voters to leave the European Union from 2015 up until the present day.
Genre: Drama, History, TV Movie
Northern Lights of Christmas
Zoey Hathaway has been working towards her lifelong goal of being a pilot for years, but everything is thrown off-course when she unexpectedly inherits a reindeer farm, along with the…
A Gingerbread Romance
With Christmas just weeks away, the architecture firm Taylor works for enters her in a contest in which the teams will design and build life-sized gingerbread houses. After the contest,…
Small Town Christmas
Author Nell Phillips' first book has become a surprise best-seller of the Christmas season. Nell's last stop on a nationwide book tour takes her to the town of Springdale, the…
A Christmas for the Books
Lifestyle guru and romance expert, Joanna Moret, has developed a fool-proof strategy for ending holiday loneliness and it's all detailed in her best-selling book, The Love Audit. After appearing on…
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The exact cause of the polycystic ovarian syndrome is unknown. However, several factors including genetics have been implicated to play a role in the development of PCOS. Women with a family history of polycystic ovarian syndrome are at a higher risk of developing this condition. Researchers have also found an association between excessive insulin production and the development of PCOS. The insulin hormone regulates the blood sugar levels and any disorder affecting the insulin mechanism may result in excessive insulin secretion, which triggers androgen secretion from the ovaries. Low grade inflammation, in response to ingestion of certain foods, may lead to the release of substances that may cause insulin resistance and cholesterol accumulation in the blood vessels or atherosclerosis. Clinical studies have demonstrated the presence of low grade inflammation in women with PCOS. Excessive exposure to the male hormone in fetal period may disrupt the function of normal gene and increase the risk of insulin resistance and low grade inflammation.
The treatment of polycystic ovarian syndrome is based on the symptoms and individual concerns such as infertility, irregular menstrual cycle, acne or obesity. Both medications and surgical treatment can be used for the management of PCOS. Infertility may be treated by fertility therapy with ovulation-inducing drugs. Clomiphene citrate, an oral anti-estrogen, may be prescribed to the patients. In some patients, the doctor may add metformin to clomiphene help induce ovulation. In patients not responding to clomiphene and metformin, gonadotropins, namely, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) can be administered by injection.


Polar Seal Heated Tops provide warmth at the touch of a button. Superlight, smart heated tops for men and women, designed for sports and comfort in adventure. POLAR SEAL heated smart tops bring you heat at the touch of a button.
It's super easy to turn on the Polar Seal with their shock resistant and waterproof buttons. They can be turned on with bare hands or even with gloves to reduce the hassle of taking off your gloves to turn it on.
There are two heating zones that are strategically placed on your back to give you maximum heat. They can be separately activated or activated at the same time depending on how much heat you want.
One of the best things about this top is that the buttons are water resistant, meaning that it's prepped for outdoor wear and sporting. It also means it's perfectly machine washable and it will lost a long time.
These heated tops have been tested for people who snowboard and ski everyday and the feedback was amazing. With bulky gloves on, you can still easily activate the heated top without having to remove your gloves.
Sometimes if its warm enough you may not even need a jacket with this top. Turn on the heat and feel like you have a jacket on. It's great for those who are a little more agile and want to ride light.
What other heated shirts are there?
We've found a few on amazon that definitely do the same thing at a slightly cheaper price. The quality may or may not be there depending on the brand you choose, but definitely check the ratings.
There's also a lot of other cool heated things, like gloves and vests that really go along well with these. These seem to be no-name brands, but could work if you're looking to save a few bucks.
But do they make a cold version???
Google "Arctic Cool." They pop up in my Facebook newsfeed a couple of times every week.
I need this in cooling male underwear/ athletic boxer version. I'd be your best customer. I'd need more than one pair per day probably.
I am unaffiliated with the company, but I live in Duluth and hear people rave about these.
What's the power draw? What size power bank do I need to last eight hours on one charge? Is that at low/high power?
It seems a bit heavy to run in with the power bank? Is it light weight material? Can it be just thrown in the washer?
I work construction. Is this rugged enough to stand up to everyday hard wear? I see a market there.
Could I get one with air conditioning please?
These look amazing! Would you market with other heating zone placements? The ability to discretely wear a lower-belly heating pad would be AMAZING for cramps and related conditions.
do you had gloves that heat on demand?
It says here that they are $129. When you click on the link that says BUY IT NOW, it takes you to a page that says they are $179. Talk about Bait and Switch.


Looking to remove background from your favorite picture? FotoEnchanter is a great source for picture masking or removing background services. Our graphic artists can remove background on picture, images, logos, and other photos leaving you with an isolated image with a transparent or white background, a great photo masking service.
Creating clipping mask in illustrator is one of the most tedious jobs you would ever encounter whether you're a graphic artist, a webmaster, newspaper columnist or just the average Joe messing with Photoshop or Illustrator. Anybody who has tried clipping images or photos with Adobe Photoshop or Adobe Illustrator knows the painstaking job of clipping the edges of an image, carefully isolating the focus image from its background. and takes a lot of time and getting used to to really make a good clipped image.
Now you dont have to do all the hardwork yourself, we at FotoEnchanter.Com will work wonders by doing the hard work for you so you can focus on other more important tasks at hand. The idea of FotoEnchanter.Com is to provide top quality clipping mask service delivered to you fast.
Masking pictures or clipping pictures is quick and easy with FotoEnchanter.Com. Just send the photograph you need masked and our highly experienced artists will do the rest, we mask pictures from the image and isolate them onto a transparent or white backgournd.
"We serve Professional Clipping Path photo edting & Masking photo editing services for everyone at not just cheapest prices but also fastest at delivering services"
This 'Clipping Path & Masking' service can also be found in our High-end Retouching Services .


This class focuses on socialization and is designed to teach your puppy basics including Sit, Here, & Loose Leash Walking. This dog training class also covers problemsolving ideas for potty training, chewing, teething, crate training, digging and more.
Helping owners to communicate with their pet by training the basics: Sit, Here, Loose Leash Walking, Leave it, & Give. This class also addresses challenges such as jumping, barking and digging.
Review learned behaviors, add commands for Wait, Place, and Down, practice commands with added distraction, gain reliability.
Daily drop off: where your dog will get the same opportunity to experience healthy pack relations while working on problems of your desire at a rate of $60.00 per day.
Week-long session: where your dog will get time away from home as well as the same opportunities as the daily drop offs at a rate of $200.00 per week.
at its commencement, will be your first opportunity to visit and give us an hour. You can expect your dog has learned how to use you for guidance while hunting for cover. When approaching cover, he/she has learned how to use smell verses sight to locate game; which will help develop that natural pointing desire. Your dog has been shot over and has been given the opportunity to discover their natural retrieve. Lastly, your dog has started to gain understanding and its position in a pack environment.
This stage in training elevates what we expect from your Pointing Dog. At this level, we expect your dog to go with us, come to us, and to stand still. It takes four weeks to establish the nonverbal points of contact. At commencement, you are again invited to spend an hour and see the progress. You can expect that your dog moves off lead with you in heel position; while hunting, your dog will go left with you when you go left; will go right with you when you go right, and will come back to you when you are idle. Your dog will have also learned a second point of contact which indicates to him/her to stop anywhere at any time.
This final 4-week stage in training is taking the foundation back to the field. You can expect at the end of your dog's time here he/she will be ready to hunt. Your dog will have been taught all areas of which he/she needs to respect during a hunt. He/she will make a great companion in the home along with the field, will be happier, and will seem to have matured years.
This stage in training elevates what we expect from your Retrieving Dog. At this level, we will focus on your dog's natural retrieve. Because a Flushing/Retrieving dog's natural tendency is to retrieve, they naturally want to flush. We will not discourage this behavior, but we will isolate it to fit our method of "train to retrieve" not "force" breaking. The train to retrieve method is about encouraging the natural instinct to pick up a bird with a strict form of obedience. With this method, your dog will be taught heel, sit, and here. Once these three commands are mastered we will move onto teaching your dog to hold under control. Your dog will learn that once an object is established in his/her mouth they must hold it until asked for it (which will always be from the sit/heel position). Your dog will be asked to hold a multitude of items from a paint roller, to dummies, to frozen birds; while walking under control with whatever they have been given until we ask for it. Once your dog is confident in "holding" we will add our first pressure to encourage your dog to reach out and grab for the objects. When this is done properly very little stimulation is required. Once your dog starts to grasp for objects from our hand we will transfer the object to the ground and add distance. At this point we add the command "Fetch".


text:
Q: Can no longer use CTRL+Left/Right in Bash Terminal I usually use CTRL+Left and CTRL+Right to navigate between words on the command-line. I switched my laptop on this morning and can no longer do that. Instead, the CTRL+Left input code gets printed in the terminal.
Ie: Here's my output when I try to navigate with CTRL+Left:
~ $ test test ;5D;5D;5D

Curiously, I can still use CTRL+Left/Right just fine in VIM.

A: Posting this an answer for visibility, as it's better than the current answer - however the real author is @corygross who wrote it as a comment above.
Cause when you have a ~/.inputrc Ubuntu doesn't source the global /etc/inputrc
Solution: manually source /etc/inputrc in your personal ~/.inputrc
set completion-ignore-case On

$include /etc/inputrc

This is much better than re-adding all the individual bits of Ubuntu's defaults back to your personal /etc/inputrc.

A: Open ~/.inputrc file and add the following lines:
# mappings for Ctrl-left-arrow and Ctrl-right-arrow for word moving
"\e[1;5C": forward-word
"\e[1;5D": backward-word

Close and reopen shell.Now you should be able to use those keys.
Reasons for this behavior ? Not quite certain. For some reason or the other your bash stopped reading /etc/inputrc file, but it should be reading the one in your home folder

redpajama_set_name: RedPajamaStackExchange


Chief Growth Officers. They're springing up all over the place aren't they. From Coca-Cola and Mondelez down. What a great new job. Or is a great new job title. CMO's are disappearing and in their place we're seeing CGO's. Because it's all about growth now isn't it. Being agile and speeding up growth is what's important….
Be brave. It's OK to be disliked.
"It's OK to be disliked? I can't afford to be disliked." We're all involved in helping businesses strive to become successful whilst those businesses (hopefully) help people make informed choices about what they do and don't allow into their lives. Because that's where we're at now. We need permission to play a part in people's lives….


PINNUO specialize in air suspension industry since 2003. We helped people fix their air suspension by replace it with a new one in our workshop. It will cost about $400-800 per strut, some customers ask if we can only replace the damaged part instead of whole air strut.
To make it possible, we try many times and finally found a way to repair air suspension shock and save money. We need a special machine that can shrink the steel rings and lock the rubber bladder and new rubber bladder and steel rings and etc.
Now we had developed the special machine and a series of replace parts for air suspension shock absorber. With these device, you can repair an air suspension shock easily and only cost $10-30.
Founder & CEO of PINNUO air suspension Co.,Ltd.
Experienced international sales, she is good at customers service and negotiation.
Photo processing and website design.


Nineteen students were treated on campus by Cal Fire/Riverside County firefighters for exposure to the irritant, which was fired after the crowd refused orders to break up, Riverside County Sheriff's Deputy Robyn Flores said.
There were no students hospitalized at the time she spoke, around 2:30 p.m. No arrests were reported, but deputies were still on the scene, she added.
The students were being treated on campus by Cal Fire/Riverside County firefighters. Pepper balls are designed to be non-lethal. They release an irritating powder chemical and are normally fired at the ground to break them and set off the chemicals.
It was the second incident of the day that drew law enforcement to Landmark Middle School. Earlier Tuesday, deputies were called to the school when there was a report of a shooting on the campus.
After a check of the grounds and classrooms, deputies declared an all-clear around 11:30 a.m.
This story is developing, check back later for more details.


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text:
Nspire
NBTC'14
NspireTV
Nspire Innovation Network is Canada's largest student-run non-profit organization in the business and technology space.
To connect innovative youth leaders with industry professionals and entrepreneurs for personal and professional development.
To empower youth with the skills and knowledge that will enable them to distinguish themselves as innovative leaders.
To inspire youth with the confidence to take on challenges and opportunities they would never have thought possible.
At Nspire Our Mantra Is
Disrupting Mindsets
Enabling Action
To foster Canada's next generation of innovative CEOs, Founders and Leaders in the business and technology space.
To connect youth leaders with industry professionals and entrepreneurs, to empower them with skills and knowledge enabling them to be distinguished as innovative leaders, and to inspire in them the confidence to take on challenges and opportunities.
Nspire originated from the visionary eagerness of University students who wanted to bridge the gap between business and technology.
Nspire originated from the visionary eagerness of University students who wanted to bridge the gap between business and technology through the creation of the National Business and Technology Conference (NBTC) in 2001. Today, Nspire's flame is fueled by brilliant and passionate student leaders, which have made Nspire a key component in building that bridge. Nspire breathes solely to connect, empower and inspire its members into a future of personal success. Its vision is to foster Canada's next generation of innovative CEO's, founders and leaders in the business and technology space.
Ever since its humble beginnings, Nspire has brought together its members with some of the most innovative business leaders, such as Sean O'Dea, Founder of Second Cup, Sean Wise, industry advisor to CBC's hit show Dragon's Den, and Anthony Lacavera, Chairman and CEO of Globalive Communications Corp. From then on, the organization has introduced various new initiatives such as the Entrepreneurship Competition in 2007, which lead students to start companies such as Dreamcube Technologies and Shape Collage Inc.
In 2009, after many successful years with NBTC, and the creation of new initiatives, Nspire was created as the organization that would unify all these endeavors under one brand.
Nspire is always seeking new ways to keep its flame ignited. It aims to deliver value to its members by launching new initiatives and programs to further aid the young Canadian innovation community.
NspireTV (NTV) brings you insights on today's market in business and technology. Latest trends and insightful topics will be discussed by industry professionals for global amplification of innovation.
The National Business and Technology Conference (NBTC) is an annual conference that connects young leaders, industry professionals, and companies across North America to learn from and inspire each other.
Discovery Series (DS) is a monthly speaker and networking event series where successful professionals share their stories and experiences with young leaders. DS is currently available at the following Ontario campuses: University of Toronto, Western University, University of Waterloo, and Wilfrid Laurier University.
Here's a sneak peek at our recent and upcoming events.
We are a dynamic group of young leaders with a unified passion for business & technology. We hustle to achieve our vision and mission.
Nspire Strategic
NBTC
Nteract
Sisun Lee
Department: Nspire Strategic
Sisun is a curious 4th year Systems Design Engineering student at the University of Waterloo that is always trying out new things to find his passion. After two years in Nanotechnology Engineering, he switched out and worked in various new fields, including roles at AMD (software dev), Facebook (data analysis), Deloitte (consulting), and Zynga (mobile product management). He is mostly excited about motivating ideas, building teams of highly passionate people, and working together to turn them into realities. This year, he will be joining Nspire to lead the online platform expansion with a team of rockstars. Look out for big updates from Nspire this year!
Grew up in: Seoul > GTA
Can't give up: Polyphasic sleep
Excited by: Change. "Change is not your enemy. It's your opportunity".
Stephanie Yiu
Department: Design and Graphics
Graphic Design graduate from OCAD University, freelance graphic designer, home-baker, coffee-lover, swimmer, and...
Grew up in: Toronto & Hong Kong.
Can't give up: Watching animal clips and wearing glasses.
Excited by: Traveling and my best friend's dachshund, Limo.
Darin Kutob
Department: Discovery Series UofT
Darin is a first year student at the University of Toronto doing Engineering, Track One. Originally from Jordan, Darin was lucky enough to live and experience both cities, Amman and Toronto. Darin is passionate about business and entrepreneurship, a passion that grew when she started accompanying her father to their family business at a very young age. She also enjoys a variety of activities including volleyball, swimming and networking with people. She is super excited to be a part of the Nspire team and looks forward to meeting you!
Grew up in: Jordan
Can't give up: Chocolate
Excited by: Challenges
Alice Han
Department: Campus Ambassador
Alice has an inclination to find out all things to which she doesn't know the answers to. She is attaining a degree in digital communications and a minor in professional writing. In her spare time, she likes to travel to Central Asia to expand her horizons and meet accomplished people her own age. Her biggest lesson learned from that is: we all start somewhere small before we grow into anything big. Just work smartly and give everything 120%!
Grew up in: China & Vancouver
Can't give up: Turkish tea, decaf coffee, and any cuisine that's really spicy.
Excited by: the thought of travelling & scuba diving
Fiorella Martinez
VP Branding and Graphics
Fiorella is a 4th year Advertising Design student at OCAD University and she just finished an internship as an Art Director with Sid Lee. She is passionate and obsessive about problem solving and design and its power to transform people. She scavenges and rummages the world around her for inspiration. As an emerging designer, she became interested in Nspire because it was an ideal environment to learn more about how business can compliment her work and to develop her leadership skills. Fiorella has a keen interest and understanding on branding, which she hopes will help Nspire reach a whole new level of awesomeness.
Grew up in: El Salvador
Can't give up: My Bamboo Wacom tablet and Pizza
Excited by: Pretty things and new ideas
Shriyah Sadana
Campus Ambassador for York University
My name is Shriyah Sadana and I am going into my second year of studies at the Schulich School of Business. Ever since I was a child, I have been extremely passionate about dancing so I love to dance in my spare time! I love people and networking and am looking forward to a fantastic year!
Grew up in: Literally all over the place! I came to Canada in 2001 when I was seven years old and have lived in Toronto, Brampton, Mississauga. I currently reside in Oakville.
Can't give up: On my family. My family's dreams and aspirations are mine and I have always tried to work at my best to make them proud.
Excited by: Everything and anything! People do fun things to be happy but I do them to be happier!
Chanakya Sinha
I am a third year student completing a specialist in Economics and a minor in Mathematics at the University of Toronto, Mississauga Campus. I have a combined interest in the automotive and finance industry. I enjoy meeting new people and discussing their perspective on different views, Innovative ideas and opinions on current affairs. If you ever need me I will be around at the UTM campus, so come up and say hi, i am sure i can amaze you.
Grew up in: The Land of Oil...Abu Dhabi, UAE
Can't give up: Bloomberg and Game Of Thrones!!
Excited by: Meeting new people!!
Alykhan Kanji
Vice President of Web Development
Department: Web Development
Alykhan Kanji is an undergraduate student at the University of Waterloo, pursuing a Bachelor's Degree in Software Engineering. As the Vice President of Web Development, he is responsible for the development of the Nspire, Discovery Series, and NBTC websites. He has a passion for software development and entrepreneurship as a member of the VeloCity program in Waterloo. His experience with web and mobile application development is a strong asset to the team.
Grew up in: Brampton, ON
Can't give up: Tools of the trade
Excited by: Gorgeous looking food
Cameron Arksey
Brand Consultant
I'm a creative professional through and through. Western University alumnus and currently Creative Director at WARPAINT Media Inc., the creative services agency. I don't think very many people start out thinking they are going to be entrepreneurs per se - or at least I didn't. It's about just knowing and feeling that you need to forge your own path and create something of your very own. Learning the term "entrepreneur" and figuring out how to turn that innate drive into a business comes later. I discovered that to be creative is to substantiate your existence in this world and I aim to help others make their mark on the world with cutting edge design and the most modern of development.
Grew up in:
Can't give up:
Excited by:
Youssef Ibrahim
Youssef is currently a third year Chemical Engineering student at the University of Toronto. He highly enjoys building connections, organizing events and improving himself. Youssef is currently the Director of Operations at the You're Next Career Network, as well as the third year Class Representative at Chem Club. Recently, he joined Nspire as a Campus Ambassador and he is excited to be part of the team!
Grew up in: The land of the Pharaohs- Egypt
Can't give up: Family
Excited by: New adventures
Ribhu Rampersad
Campus Ambassador - UTSG
Ribhu is a 3rd Year Chemical Engineering student passionate about optimizing operational processes by combining attributes of the business, technology and engineering industries. His strengths lie in creating meaningful connections to build networks that are beneficial to all parties involved. He is motivated by a desire for continuous growth, whether it be personal or organizational, and is looking forward to executing his role to assist in the expansion of Nspire's network and exposure.
Grew up in: Trinidad & Tobago
Can't give up: Trinidadian food and music
Excited by: Achievement
Vernon Tam
Campus Ambassador - Waterloo
Vernon is a first year student at the University of Waterloo and he is currently studying Accounting and Financial Management. When he's not on the basketball court, watching the Food Network or catching up on Suits, you can find him working away on his latest endeavour. He is always eager to learn and try new things from academic/professional challenges to Try-It-Night hip hop class. During his senior year, he worked on Student Council as the External Affairs Officer, competed in Anaheim, California representing DECA Ontario and worked at a summer camp teaching kids basketball. Vernon is an optimistic and hardworking individual who is always ready to commit his efforts towards his team.
Grew up in: Markham, Ontario
Can't give up: Basketball (my 1 true love)
Excited by: Random Acts of Kindness
Rebecca Luo
Rebecca Luo is a second year student in BMOS at the University of Western Ontario. She has been working in the area of fundraising, sponsorship, finance and business development since her first year of high school for various non-profits, charities, and most recently, contributing to an Investors Group client base at an existing $60 million in assets under management. Rebecca's past experiences start from humble beginnings, closing her first sponsorship deal for a whopping $20 Swiss Chalet gift card, to earning the Highest Number of Credit Card Gifts secured for the Richard Ivey School of Business Annual Fund. Rebecca is also a national member of the Canadian junior kungfu team, and a national multiple gold-medalist. She has been a choreographer and performer for various Chinese arts and culture festivals, having been invited by the CEO of GE Canada to perform at the Shanghai World Expo Launch and meeting the Toronto Counsel General of China. Rebecca is often regarded by her colleagues and managers as someone who is "results-oriented", "diligent" and "extremely hard-working". Funnily enough, to contrast this hard-set attitude, Rebecca is a self-admitted "girly girl" who loves the fashion and beauty industry, having worked as a professional makeup artist (during high school) backstage and at SEARS Canada as the youngest Beauty Advsor in the department. Her favourite animal is a dog for their widely known unconditional love and undying loyalty.
Grew up in: Mississauga, Ontario
Can't give up: Spending time with loved ones
Excited by: All things glamorous - cosmetics, fashion, accessories
Massimo Gordillo
Hey there, I'm Massimo. I rather enjoy fair competition in any medium, be it soccer or chess. I'm currently studying Industrial Engineering at the University of Toronto and I'm a big fan of optimization and system design. I like the idea of contributing to big things and wanting the best for others, I always try to promote the things I enjoy to other people. I can't stand musical theatre but I do enjoy participating in it. I also don't like cake.
Grew up in: Toronto, Ontario
Can't give up: Music, it is my drive and my love.
Excited by: Ingenius engineering and inteligent design.
Harsh Patel
Ryerson Ambassador
Hi, my name is Harsh. I'm in my third year at Ryerson. I'm from Markham, went to Bur Oak Secondary School. I participate in DECA and I have the position of Director of Promotions for the student group I am in at Ryerson. I like to play some recreational basketball or mostly every sport. I'm really outgoing so don't be shy for a handshake and have a good sense of humor.
Grew up in: I grew up in Scarborough. I lived near STC and went to woburn for year before I moved to Markham.
Can't give up: I can't give up my passion for games. Also, I can't give up my dreams.
Excited by: The most excitement I ever had was when I stepped into Disney when I was little. Regardless the fact, that there are so many people there, there's people in costumes dancing, singing this "good morning song" to you as you enter. As you're about to leave Mickey comes onto the stage. It was pretty exciting.
Julie Nguyen
Department: Discovery Series Waterloo/Laurier
Hey there! My name's Julie Nguyen, and i'm currently a second year student at the University of Waterloo. I'm studying two of the most bizarre subjects combined- Biotechnology and Chartered Accountancy. But trust me, I don't think I will be doing accounting for cells. I have a very diversified set of interests and I take pleasure in facilitating others' developments. I founded a non profit organization known as the Sparks Youth Enrichment Group, I am a Shad Valley 2011 Alumni, I interned for Impact Entrepreneurial Group as a Marketing Developer, and assisted with some research in Nutritional Sciences at the University of Toronto. I love event planning and on top of that Innovation, design technology, education and health are just some of the things that fascinate me. I am a strong believer in continual learning and love meeting new people. Let's talk sometime!
Grew up in: Toronto, ON
Can't give up: My phone
Excited by: Meeting new people with similar interests and those who know how to have a good time :)
Karolina Deoniziak
Karolina is a third year business of administration student at Wilfrid Laurier University. She is an innovative, creative, and technology driven individual always seeking to be inspired by likeminded people. From organizing a flag football team to planning a leadership and business conference, you will always find her looking for opportunities to bring people together. She has a passion for marketing and often criticizes different brands on trending websites like Fastcompany or AllThingsD. When she is not planning her next ventures in life she is making music on her violin, is immersed in photography and taking pictures, or practicing her baking skills. She is most looking forward to integrating different marketing efforts across campuses and executing her visions with her role at Nspire.
Grew up in: Kitchener
Can't give up: Nikon D3100
Excited by: FOOD!
Michael Pawly
Being a second year Biomedical Sciences student at the University of Ottawa, my aim is to gain knowledge from inside the classroom, just as much as outside it. Having grown up in three different continents, I realized how competitive the world is, and have learnt to enjoy life to the fullest while pushing myself in everything I do. As the son of a successful entrepreneur, I've always had a deep passion for business and social entrepreneurship, finding an innovative way to help people around the world. I am also a devoted soccer and NBA fan, with a music addiction. "You come into the world with nothing, and the purpose of your life is to make something out of nothing." -Henry Louis Mencken
Can't give up: Champions League and NBA playoffs
Excited by: New experiences
Annie Zhang
Department: Discovery Series Western
Annie is a second year student at the University of Western Ontario. She is currently specializing in Economics, Politics and Philosophy with prospects of entering the Richard Ivey School of Business in the upcoming year. Originally a die-hard figure skating addict and later turned passionate musician, she pursued numerous performance and leadership roles in the athletics and performing arts such as being a member of the Canadian Wind Orchestra and competing at the Canadian Synchronized Skating Championships. She is passionate about strategy, challenging traditional norms and problem solving. Striving for a career in strategic consulting, she hopes to constantly create unique solutions to problems and propose changes to flawed systems. In the past summer, she worked as a social media marketer for a career management company called Magnify Your Marketability. In her free time, she enjoys obsessively watching figure skating videos, music jams, being active, being in nature, and absorbing knowledge.
Grew up in: A little too many suburbs.
Can't give up: Night Jogs
Excited by: Going on random adventures. After all, the sky's the limit.
Sofia Remtulla
Sofia is a curious and adventurous second year Commerce student at Queen's University. She always strives to take on new challenges and engage herself in new opportunities. Plans for Sofia's future are still vague so she aims to make the most out of the present by filling her time with activities such as Yoga and Bollywood dance as well as involving herself in leadership roles with AIESEC Queen's and the Queen's Commerce Corporate Challenge Conference. These activities foster her diverse skill set by providing her with the means to work in different teams and tackle new projects. Travel is very important to Sofia, as she realizes that there are so many people to meet and so many things to learn about other cultures. Her most recent endeavor was teaching in a slum in India to less fortunate students. Sofia believes that the key to success lies in networking and meeting the right people so don't be afraid to strike up a conversation!
Grew up in: my own little corner of the universe, over the moon most likely
Can't give up: Friends and family
Excited by: Anything chocolate
Elizabeth de Roode
Growing up, Elizabeth always loved math, science and people. Pursuing her passion for optimization of these three has led her to the Chemical Engineering Department at the University of Toronto. Taking a leap of faith to discover the power in her potential, she is new to the Nspire team this year. She is excited to create a significant impact by providing lasting, relevant value to the participants of her Discovery Series events. If you didn't catch Elizabeth during F!rosh week as a purple Head Leedur, you can see her in the March shows of Skule Nite, dancing, singing and acting!
Grew up in: Muskoka
Can't give up: Animals
Excited by: Learning new things!
Arshdeep Sidhu
Department: National Business and Technology Conference
Arshdeep is a third year student at the Richard Ivey School of Business. Aside from Nspire, he oversees the student operations for a non-profit called OneProsper International. His interests lie in disruptive technology, entrepreneurship and sustainability. When he's not madly typing away on his laptop, you'll find him catching up on the latest episode of Suits, at the basketball court, or out for a long run.
Grew up in: Brampton
Can't give up: Daily Elon Musk updates
Excited by: Young people proving old frameworks wrong
Erika Tsang
Erika Tsang is a second year Global Economics student at the University of Western Ontario. She is passionate about branding, strategy and sustainability and likes to integrate these interests into everything she commits to. Erika is keen on bringing people together for one cause and adding value to the event experience. From organizing charitable fundraisers to teaching karate camps to volunteering for fashion shows, you will find her working on a project with a team of passionate, like-minded people. When she is not running around campus with Starbucks Passion Tea Lemonade in hand, she is an avid foodie and treks around the city looking for hidden gems, such as rustic cafes or fusion restaurants. She hopes to travel around the world one day to try as many delicacies as possible, and attend New York Fashion Week.
Grew up in: North York, Thornhill, Richmond Hill - all over GTA
Can't give up: Wine and cheese - my favourite nights are where I can watch my favourite shows and enjoy a plate of Brie and Iberico cheese
Excited by: indie concerts and music festivals
Sucheta Shankar
VP of Marketing and Communications
Sucheta started talking at six months and put together complete sentences by nine months, albeit simplistic ones. She believes in the power of communication and its ability to make exciting things happen. She is currently a postgraduate advertising copywriting student at Humber and previously completed her undergraduate bachelor's degree at Queen's University. Her passion lies in creating great advertising work which is effective and appealing. Currently, she juggles her time between writing for Arbitrage Magazine, creating pages upon pages of speculative advertising campaigns for school and working as a freelance writer.
Grew up in: a one season (summer) destination
Can't give up: Lists
Excited by: minimalist design and clever advertising campaigns
Mantas Matelis
Lead Web Developer
Department: Nteract
Mantas is a first year student at the University of Waterloo and Wilfrid Laurier University, pursuing a Bachelors in Computer Science and Bachelors in Business Administration. Computers have always been his passion and he is looking to use these skills to better youth in business through Nteract. Feel free to connect!
Excited by: Complex systems.
Soha Yasrebi
Soha is a fourth year Electrical Engineering student pursuing a business minor at University of Toronto. She has completed internships at AMD and Deloitte in the past year and is ready for her next big step! Soha is fluent in French, loves meeting new people and is fascinated by different cultures. She's all about new experiences like jumping from the sky and loves to dance, play tennis, travel and go shopping (of course)!
Grew up in: 10,000 km away, IRAN
Can't give up: Combination of movies, popcorn and coke
Excited by: Making new friends
Jonah Hetherington
VP Finance
Jonah is a 2nd year Economics student at the University of Western Ontario with the hopes of earning an HBA from the Ivey Business School. After finishing first year studying Financial Modelling and Computer Science, he realized his passion was and has been finance all along, which has driven almost every extra-curricular involvement he's been a part of. From being an active member of Western Investment Club and Capital Markets; visiting top finance firms in New York City to an internship at Integral Wealth Securities, a national boutique investment firm, Jonah's extensive finance experience has culminated in the VP Finance role with Nspire. He is a true believer that money does indeed bring happiness, so long as you don't spend it on yourself. He wishes to achieve that by creating as much value for business and technology students through Nspire. Outside of the financial world, Jonah is a brother of the Phi Gamma Delta fraternity, where he won the annual Airbands dance competition with his pledge class. He is also a slam poet and national ranking sport karate fighter. He is always willing to meet new people, especially those that don't take everything in life too seriously.
Grew up in: Born in Hong Kong / Raised in Ottawa
Can't give up: Dairy products, especially milk
Excited by: The ideas that come to you in the shower
Ian King
Nteract Program Manager
Graduating from McGill University with a BA in Philosophy and English Literature, Ian went directly into the summer 2013 cohort of Bitmaker Labs' nine week, Full Stack Web Development program. Deeply interested in the intersection of art and technology, as applied through entrepreneurship, Ian has led initiatives with the Impact Entrepreneurship Group and the Canadian Undergraduate Technology Conference Foundation. Moreover, as a student politician at McGill, he chaired his own integrative research conference and organized numerous fundraisers for the Montreal Children's Hospital. Having competed in Startup Weekends in both Montreal and Toronto, Ian works efficiently in Design and Frontend Development roles; nonetheless, his Bitmaker Labs training has made him well-versed in Ruby on Rails as well. A religious conference attendee at events like SociaLIGHT, CUTC, and NBTC, Ian views his recent passion for hackathons as a pragmatic extension of his growing interest in technology. He is looking forward to leveraging his leadership experience in event planning, along with his growing capacities as a web developer, to direct the Nteract team in the exploration of several online projects to expand Nspire's global reach. Before him the horizon is uncertain and, yet, all he can see are possibilities – he warmly welcomes what the future may bring.
Grew up in: Brampton, Ontario (a.k.a. btown)
Can't give up: Sports, Spirituality, Poetry, Philosophy, or Entrepreneurship
Excited by: The future of publishing on the web and how that will affect print media. He is also deeply excited by the future of online education and how that will influence the direction of the currently entrenched education system.
Matthew Magdales
Co-Managing Director
4th year Laurier biz student. VC-in-training.
Can't give up: Twitter.
Excited by: Passionate people.
Singyu Chan
Singyu is a first year iBBA student at York University's Schulich School of Business. The word "connect" defines him best because he is indefinitely seen interacting and communicating with other individuals. His passion truly lies within the effective use of his interpersonal abilities in order to create value and desirable outcomes. Singyu is also described to be an individual that is devoted to community involvement. Throughout high school, he has contributed to the community by serving pivotal roles in various organizations. In addition, he has accrued significant work experiences as an intern at a tech startup company and also at a more established firm known as BMW. Singyu aspires to secure a CPA designation shortly after graduation to pursue a career in the field of accounting. At Nspire, Singyu is anxious to challenge obstacles with optimism and reach unprecedented heights.
Can't give up: Nutella & Family.
Excited by: Connecting with others.
Daniela Trivanovic
Producer/Host
Department: NspireTV
I am currently in my second year at the University of Toronto Mississauga, pursuing my Bachelor of Commerce Degree. After finishing my first year, I have decided to specialize in Marketing, with a major in Economics. As an active member of the Undergraduate Commerce Society at UTM, I assist in producing and hosting "CommerceTV", raising awareness of events and opportunities within the school. When the business cloths are put away, I continue to fuel my passion for dance as part of a Serbian Folk Dancing group. For over 15 years, I have participated in competitions, helped instruct youth, travelled around the world, and am still going strong! I love to travelling, exporting the great things this city has to offer, and meeting new people to share these experiences with!
Grew up in: Toronto
Can't give up: Food, dance and exploring the city
Excited by: People
Angela Wong
Hi everyone, I'm Angela. I'll be completing the BBA program at Wilfrid Laurier University in the next year with a specialization in Marketing. I'm fascinated by how easily things can change, but more importantly, by how even the littlest things can make the biggest difference. That being said, I think Attitude makes all the difference. I see the world as a sea of opportunities, and I live my life like a captain steering a ship through uncharted territory. A little scared, yes, but mostly thrilled and with insatiable curiosity! And if I had a motto, it'd be to "Nspire, or be Nspired"... See what I did there? ;)
Grew up in: a music video for a 90's pop song
Can't give up: music, smiling, laughing, tears of joy... and any other telltale signs of happiness :)
Excited by: good eats, people with passion, and learning new things!
Jitesh Vyas
VP External Affairs
I'm a second year student at Western University and I'm loving the business and technology space. Through working in this space, I've learned to strategize my thought process and sharpen my decision-making ability; both of which are essential in life. Beyond that, I've discovered my entrepreneurial qualities, like being fascinated by complex problems, and obsessed with solving them. My side interests include management theory, basketball and staying up to date on tech news. I'm available any hour of the day for substantial conversations, or if work needs to get done - that's my promise!
Grew up in: My own world.
Can't give up: Blogging. (I tried, but couldn't)
Excited by: LeBron James and Sachin Tendulkar
Be part of our rockstar team!
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We would like to extend our appreciation to our prominent media partners who continue to feature our initiatives, events, and competitions.
Arbitrage Magazine
Nspire's NBTC'13: Intersection of Inspiration and Passion
Entrepreneurship: Create Your Own Opportunities, Get Where You Want to Be
TalentEgg On Site: NBTC 2013 And The Women In Entrepreneurship Panel
Interview: Bridgit, Winner of the NBTC Entrepreneurship Competition
NBTC | Interview with the Winners of the Capital One Consulting Competition
Canadian Female Founders on Why They Were Destined to be Entrepreneurs
The National Business and Technology Conference 2012
The Keys to a Strong Personal Brand
Student Business and Technology Conference in Toronto Next Month
Design. Charity. Life.
Where Canada's Business and Technology Students Connect and Compete: NBTC 2013
Nspire Discovery Series - The Team That Works
C4 Sustainability Challenge
Ideas Ignite at Entrepreneurship Weekend Event
National Business and Technology Conference
Duo sounds note of caution
Calling All Aspiring Entrepreneurs – Compete for a $25,000 Valued Prize at NBTC
The Iron Warrior
C4 Challenge
Atrium Media Group
24 Hour Startup - What can you create in 24 hours?
What is Nspire
Nspire in the Media
© 2013 Nspire Innovation Network.


Botrydium granulatum (Linnaeus) Greville Drawdown zone, Pitsford Water SSSI, Northamptonshire, UK.
Huxley, R. & Pentecost, A. (2002). Order Oedogoniales. In: The Freshwater Algal Flora of the British Isles. An identification guide to freshwater and terrestrial algae. (John, D.M., Whitton, B.A. & Brook, A.J. Eds), pp. 409-432. Cambridge: Cambridge University Press.
Johnson, L.R. (2011). Phylum Xanthophyta (Tribophyta) (Yellow-green algae). Orders Botrydiales, Mischococcales, Rhizochloridales, Tribonematales. In: The freshwater algal flora of the British Isles. An identification guide to freshwater and terrestrial algae. Second edition. (John, D.M., Whitton, B.A. & Brook, A.J. Eds), pp. 318-335. Cambridge: Cambridge University Press.
Zarina, A., Masud-ul-Hasan & Shameel, M. (2005). Taxonomic study of Vaucheriophyta Shameel from certain areas of the Punjab and NWFP, Pakistan. Int. J. Phycol. Phycochem. 1(2): 159-166.
Accesses: This record has been accessed by users 6695 times since it was created.
Gil-Rodriguez, M.C., Losada-Lima, A. & Moro Abad, L. (2003). Botrydium granulatum ( Linnaeus) Greville, primera cita del género en las islas Canarias. Algas Número especial 23-24: .
Janet, C. (1918). Sur le Botrydium granulatum??. : .
Mercer, E.I., London, R.A., Kent, I.S.A. & Taylor, A.J. (1974). Sterols, sterol esters and fatty acids of Botrydium granulatum, Tribonema aequale and Monodus subterraneus. Phytochemistry 13: 845-852.
Mitchell, M.E. (1969). A note on Botrydium Granulatum (L.) Grev. in Ireland. The Irish Naturalists' Journal 16: 245.
Moewus, F. (1940). Über die Sexualität von Botrydium granulatum. Biol. Zentral. 60: 484-498.
Randhawa, M.S. (1940). A note on a club shaped variety of Botrydium granulatum (L.) Grev. var. clavaeformis var. nov. Proceedings of the Indian Academy of Sciences, Section B 11: 222-224.
Rosenberg, M. (1930). Die geschlechtliche Fortpflanzung von Botrydium granulatum Grev.. Österr. Bot. Zeit. 79: 289-296.
Tell, G. (1970). Contribucion al conocimiento de las algas del Suelo Bonaerense I. Botrydium granulatum y B. tuberosum. Darwiniana 16: 139-143.