text:
#8M: 50% of public positions held by women, but without decision-making power
Even though women in public positions are more conspicuous, few are publicly known by first and last names, nor are their achievements known.
Por lalupanicaragua 8 marzo, 2021 15 septiembre, 2021 123
Although the 50/50 law means more women occupy public positions, they do not have decision-making power in Daniel Ortega's regime. Illustration Luis González/La Lupa
The regime of Daniel Ortega and Rosario Murillo established by law «gender equity» in Nicaragua. With Law 50-50, which reformed the Law of Municipalities or Law 40, women began to gain spaces in the mayoralties of Nicaragua, but in exchange for having a "designated, clientelist and partisan" presence in public office, affirms the sociologist and feminist.
The reform, approved on March 8, 2012, established the so-called policy of distributing 50-50 positions of public election, that is, half men and half women. The application in the municipal governments, in some way, contributed to equalize the gender composition of the authorities in the Municipal Councils, although this does not mean that women were given real power.
«They are women who are only there, because they were put in place by the government party and who are more than anything like a mask, they are symbolic women who serve to mask and give the face that here there is parity in the participation of women and to hide or wanting to show a supposed democratic will on the part of the Government," says Montenegro.
Even though women in public positions are more conspicuous, few are publicly known by first and last names, nor are their achievements known. They do not provide interviews, and the reports from the ministries they lead are communicated by the spokeswoman for the Sandinista regime, Rosario Murillo, who, along with Daniel Ortega, has been accused of moving them like chess pieces.
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Thirteen years have passed since the approval of the Law on Equal Rights and Opportunities – Law 50/50 -. However, the long-awaited gender equality in all areas; political, social and economic continues "an outstanding debt with women", although for some organizations, the "situation has worsened".
Although theoretically the participation of women was expanded, those who occupy a position in the Municipal Councils are still subordinate to the male leadership in those spaces and are not in the «capacity to decide.»
The sociologist believes that the regime tries to exhibit a «supposed parity» of gender, which in reality «lacks institutional support, political credibility or authority.»
"It is rather a strategy of disaggregation of the public patriarchy, by means of which women are not prevented from entering the state public space, but where control and the best positions are held by men," explains Montenegro.
Women who hold public office «enter in a subordinate way,» says the sociologist.
«In the end, they are all subordinate, because the only power that is obeyed, one has absolute obedience, is that of Daniel Ortega and his wife, in two dishes that is,» says Montenegro.
The teacher, sociologist and feminist activist who directs La Corriente, María Teresa Blandón, clarifies that the approval of legislation that favors gender parity "is not a favor" of a government, but is "the object of long feminist struggles and demands because the work of women is recognized".
It points out that –because of the context in which Law 50/50 is applied– "it is just a mirage, which means that the regime does not lie when saying that these years the participation of women has significantly increased, but it is not like that. in making decisions».
Men control the power
The study "Without a Republic and without citizenship. Political participation of women in Nicaragua in the legal and political context of 2014", from the Center for Constitutional Rights, revealed that the implementation of Law 50-50 has not changed the "condition of gender subordination, although the number has changed. correlation in favor of women".
In the findings, which were recorded from interviews and focus groups, the study, which was led by Montenegro, highlights that women have «little margin for decision-making» in political spaces and, evidently, control continues to be in the same way. firmly in the hands of men.
"At the local level, these women have neither autonomy nor representation, nor the ability to decide anything, because they are completely subordinate (…) let's no longer talk about participation as deputies in the National Assembly, which is absolutely useless, because no one there decide, who decides is Rosario and Daniel Ortega. Everything is pure appearance", emphasizes Montenegro.
At the level of municipalities and State institutions, some women who have held important positions have finally been relegated and forced to obey the dictatorial couple with submission.
Aminta Granera: From strong woman to formal figure
On September 5, 2006, Aminta Elena Granera Sacasa was appointed director of the National Police, in the last stage of the Government of Enrique Bolaños.
Her appointment generated great expectations, since she received a totally delegitimized institution and it is assumed that she would end police corruption, as well as guarantee professionalism within the police ranks.
The police chief became a respected person in Nicaragua, to the point that she, in the polls, led the list of public figures with a favorable opinion ahead of Ortega and Murillo himself.
In 2007, with the arrival of Daniel Ortega to power, the first police commissioner submitted to the authoritarianism and arbitrariness of the regime. During the inauguration, Ortega swore in the head of the National Police and reminded her of the institution's Sandinista roots.
Granera Sacasa, little by little, was stripped of its authority and performed only public relations functions. Some police sources began to claim that she held a position of adornment.
In 2011, Ortega extended Granera Sacasa as head of the National Police and ratified it again in 2016, despite the fact that the decision was not legal. Some security analysts saw that the intention was to wear down any presidential pretense of this woman.
Granera Sacasa bowed to Ortega's decisions and remained silent in the face of events that the entire society repudiated, such as the El Carrizo massacre (2011), the brutal attacks and robberies of the #OcupaINSS protests (2013) and the Jagüitas massacre (2015), to name a few.
After she assumed the third term of her management in that institution, the public activities in which she participated were easily counted. Behind the police chief was always the male figure of Commissioner General Róger Ramírez Guzmán, who it is said was the one who exercised the real command within the police structure.
Ortega prepared the way for his father-in-law Francisco Díaz, sending several deputy directors of the Police to retirement, including Ramírez Guzmán.
Granera Sacasa gradually lost control of the Police, the openness that she had with the population and the media. She no longer appeared at any public activity, and after 2015 her absence was more noticeable.
Also: Marta María Blandón: «Women matter only when they are at the service of the dictatorship in power»
In April 2018, she was silent and did not comment on the massacre carried out by the regime against the population.
Díaz was the one who appeared in public justifying the murders through appearances at the face of the official media.
One of the last public appearances of Granera at the head of the Nicaraguan Police, occurred on April 23, 2018, when she participated in the funeral service of the police Juana Francisca Aguilar Cano, who died during the protests against Ortega.
At the end of April 2018, it transpired that Granera Sacasa resigned from her position, while the country was in full turmoil and immersed in an unprecedented crisis.
On August 23 of that same year, through a presidential agreement published in La Gaceta, it was announced that Granera Sacasa had "concluded her career in the National Police" and her retirement was confirmed.
In September of that year, Díaz assumed the leadership of the public institution. A position that she in practice held long before.
Reyna Rueda: Fidel Moreno, the voice in the Mayor's Office of Managua
The study conducted by Montenegro revealed that "putting and removing" officials in a whimsical way and without giving any kind of explanations, going over the government bodies of the municipalities, discourages the participation of women.
Although in the last elections of 2017, women reached more than 40% participation in the 153 municipalities of the country, their contribution to decision-making remains limited, as in the case of the current mayor of Managua, Reyna Juanita Rueda Alvarado.
It is said that he is a man of confidence of the spokeswoman of the regime, Rosario Murillo, completely overshadowing the figure of Reyna Rueda.
Rueda who began to have an outstanding voice when she served as secretary of the Managua Municipal Council in the previous administration, since she assumed her new position as mayor since January 4, 2018, now she limits herself to making tours of the markets and only has protagonist in the sessions of the Mayor's Office, when he reads the agenda and moderates the interventions.
While, Moreno is the only one authorized to give the reports, which is the responsibility of the mayor by law. He is the figure in the Mayor's Office that reports on catastrophes, floods, announces winter plans and agreements with different agencies.
When journalist Daysi Torres took office on July 7, 2009, replacing the dead Alexis Argüello, the story was the same that Rueda is repeating now.
Moreno, considered the "de facto mayor", has been the main voice within the commune ever since.
The curse of the Women's Ministry: 13 women have paraded as headlines
The Ministry of Women, formerly called the Nicaraguan Institute for Women (INIM) that was created in 1987, is an institution that remains in constant instability, since Daniel Ortega came to power, through which more than 10 directors have passed.
Emilia Torres, was the first director of INIM, for a few months, at the beginning of Ortega's mandate in January 2007, but she was removed from her position in March, under the pretext that she passed to the Ministry of Culture.
That same year, at least three women held that position at INIM, including Rita Fletes (R.I.P), who was there until November and was replaced by Claudia Cerda López, who held the director's chair until 2008.
Later, Lilia María Alfaro took office, until March 2009, when she was replaced by Perla López Miranda, who was there until March 2010.
At the Institute, which was supposed to ensure gender equality in the State, the changes continued to be active. Gustavo Porras' sister-in-law, Isabel Green Casaya, assumed the leadership of INIM until 2013, when the institution was renamed and Arlen Patricia Vargas Padilla was appointed minister.
The changes continued and on December 17, 2015, Vargas Padilla was replaced by Martha Erica Martínez González, who was removed from the position after one month and two days after being assigned, and in her place was replaced by Ángela Yadira Meza Vargas in 2016.
The last woman to assume the position of that unit was Jessica Yaoska Padilla Leiva, appointed on May 7, 2019.
This ministry, in theory, is responsible for formulating, promoting, coordinating, executing and evaluating government policies, plans, programs, and projects that guarantee the "participation of women in the process of economic, social, cultural and political development of the country». But in practice there are no results.
«They are not real, they have no hold, they have no impact, practically (the Ministry) is a shell and is demolished, what there are, employees who in the end are supernumerary, I do not think they do absolutely anything more than proselytism and activism in favor of the Government", criticizes Montenegro.
The sociologist affirms that women in reality are nothing more than «objects that can be manipulated by the lady with the hand of the rings», which is the one who in practice manages the «bureaucratic changes within the institutions».
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«They are irrelevant, they are interchangeable, they are disposable, they pass without shame or glory, because there is no merit, there is no representation, and there is no capacity in terms of deciding, they have been chosen», argues Montenegro.
Greater presence, little known
An exhaustive review of La Lupa shows that the presence of women in public office is significant. Both deputies and mayors or vice mayors and ministers exceed 40% of representation.
Although it is described as «an insufficient measure» for a public policy specialist who spoke with La Lupa on condition of anonymity for fear of repression against critical voices in Nicaragua, she points out that «on paper it is progress.»
"It does not level the political playing field specifically, because you can have 50 women and 50 men legislators, you can have 50 women mayors and 50 men mayors in the case of municipalities, however, that is not enough to say that women are making decisions. or that they have real power to make decisions, «he says.
These increases in political participation, although numerically they show improvements, for the specialist in public policies point out that they are actually positions that «are subordinate to the decisions of the ruling party … because parallel authorities are imposed on them by the centralization of power that even their functions are canceled ".
The Top Ten of the Global Gender Gap
Law 50/50 sought – according to what has been proposed since its approval in 2008 – to guarantee equitable participation for women, especially in popularly elected positions and appointments. Therefore, months before the municipal elections of 2012, it brought a reform to the Municipalities Law and the Electoral Law, which forced the political parties to reform their proposals for candidacies.
After these changes, which brought about a considerable increase in the participation of women, at least quantitatively, Nicaragua began to rank in the renowned report of the World Economic Forum (WUF, for its acronym in English) – The Global Gender Gap Report 2013 – which ranked the country, for the first time, in the exclusive Top Ten, after ranking 90 in 2007.
«Nicaragua continues to be the most advanced country in the region in terms of gender equality, ranking tenth in the world index,» says the 2013 document when it ranked tenth. And a year later it rose 5 positions.
The 2013 report ranked 136 countries "according to their ability to close the gender gap in four key areas: health and survival; educational achievements; political participation and economic equality ".
For Blandón, these evaluations, where only purely quantitative aspects of women's participation are taken into account, «cannot show the true meaning of strengthening gender equity.»
The public policy specialist also points out that this type of ranking «does not measure the quality of life of these women, nor the decision-making capacity that they are given in those positions that they measure by numbers.»
A mere numerical data
However, from the regime, year after year the "participation of women" in public positions is celebrated even though it is Murillo who concentrates the information and power, and the rest of the civil servants go into the background, and appear only at parties popular or minor acts, according to the official media.
The data reveal that in the 16 ministries the presence of women in senior positions is 46.6%, that is, 14 women hold positions as ministers and vice ministers. In five of these ministries; Women, Health, Family, Environment and Natural Resources, women who held positions as ministers or vice ministers were removed – in at least three cases – before they had completed one or two years in office. And it is well known that the portfolios they manage are those that are traditionally assigned to women.
In the case of the National Assembly, the situation is quite similar, in few occasions the voice of the deputies or alternates is heard, and that 46.4% of the seats are held by women in the national, departmental, regional and regional councils. of the Central American Parliament, in the case of the proprietors, while in the case of the alternate deputies it rises to 47.32%.
In the case of the positions of mayors and vice-mayors, women obtained in 2017 -after the questioned municipal elections- a participation of 44.4% in the position of mayors, that is, 68 of the 153 positions were held by women.
In the last three years, five of the 153 municipalities have undergone changes: one due to the death of a Sandinista mayor; another for the dispossession carried out by the regime and three related to resignations due to alleged health or retirement problems. These situations led to a quantitative increase of 2% in the participation of women in the position of mayor or vice mayor.
«Woman is relegated»
In 2007, Ruth Selma Herrera, a researcher on water and sanitation issues, assumed the executive presidency of the Nicaraguan Company of Aqueducts and Sewers (Enacal), but she was in office until April 8, 2010.
Herrera argues that the «system» reduces the good performance that a woman can have in a management or Ministry position. The former executive president of Enacal believes that Law 50-50 is part of the «political propaganda» promoted by the regime.
"Neither this Government, nor that of (Enrique) Bolaños, nor that of (Arnoldo) Alemán, nor that of Doña Violeta (Barrios de Chamorro), nor that of (Anastasio) Somoza, have done anything to really claim that recognition respectful, real. It has always been handled, even with this Government, as a political propaganda to throw the story at the national level, and at the international level, like that here women are given the opportunity ", Herrera mentions.
The former executive president of Enacal, considers that the legislation that the regime presumes so much, was approved by «pure formality», because if they put a woman in a position and do not listen to her proposals, they do not respect and support her, the appointment becomes » A big lie».
«I believe that here there are many women who have been figurines in the institutions and that in the end others are behind the decisions, not only in the Mayor's Office of Managua, in a lot of institutions and it depends on whether one wants to be,» he says.
Herrera resigned after considering that it was the opportune moment. "I did what I think I had to do and I quit when I felt I had to quit. I have to make my voice heard or if I do not resign from the position, you cannot be in a position because they put you there, to earn the money and to say that there are women, and here women, sometimes, disrespect themselves when they accept to be puppets of any government that appoints them, they do not let them decide and then they put an advisor", he questions.
According to Montenegro, the numerical presence of women within a «patriarchal, authoritarian regime does not modify it or make it democratic.»
"Gender parity loses all meaning when the regime lacks legitimacy of origin, legitimacy of the process and legitimacy of the result, because the lack of independence of the powers prevents compliance with the responsibility of accountability between the powers of the State and the citizenship and absolute power is exercised as a form of domination", Esteem Montenegro.
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Lattice Biologics, Ltd. - 607852 - 08/27/2020
WARNING LETTER
Lattice Biologics, Ltd. MARCS-CMS 607852 — August 27, 2020
CBER 20-06
Guy Cook
Recipient Title
Lattice Biologics, Ltd.
512 E Madison Avenue
News@latticebiologics.com
Issuing Office:
Office of Compliance and Biologics Quality
This is to advise you that the United States Food and Drug Administration (FDA) and the Federal Trade Commission (FTC) have reviewed your website at www.latticebiologics.com, most recently in August 2020. We also recently reviewed your social media websites at www.youtube.com/watch?v=jyH85f9K-fk and www.twitter.com/latticebio. The FDA has learned that you market or distribute an amniotic fluid product (sometimes referred to as AmnioBoost) in the United States to mitigate, prevent, treat, diagnose, or cure Severe Acute Respiratory Syndrome (SARS) or Acute Respiratory Distress Syndrome (ARDS) related to Coronavirus Disease 2019 (COVID-19)1 in people.
Based on our review, this product is an unapproved new drug under section 505 of the Federal Food, Drug, and Cosmetic Act (FD&C Act), 21 U.S.C. § 355. Furthermore, this product is a misbranded drug under section 502 of the FD&C Act, 21 U.S.C. § 352. The introduction or delivery for introduction of this product into interstate commerce is prohibited under sections 301(a) and (d) of the FD&C Act, 21 U.S.C. § 331(a) and (d).
Your product is also a biological product under section 351 of the Public Health Service Act (PHS Act), 42 U.S.C. § 262. In order to lawfully market a drug that is also a biological product, a valid biologics license application (BLA) must be in effect under the PHS Act. 42 U.S.C. § 262(a). Such licenses are issued only after a demonstration that the product is safe, pure, and potent. While in the development stage, such products may be distributed for clinical use in humans only if the sponsor has an investigational new drug application (IND) in effect as specified by FDA regulations. 21 U.S.C. § 355(i); 42 U.S.C. § 262(a)(3); 21 C.F.R. 601.21; 21 C.F.R. Part 312. Your amniotic fluid product is not the subject of an approved BLA nor is there an IND in effect for your product.
There is currently a global outbreak of respiratory disease caused by a novel coronavirus that has been named "severe acute respiratory syndrome coronavirus 2" (SARS-CoV-2). The disease caused by the virus has been named "Coronavirus Disease 2019" (COVID-19). On January 31, 2020, the Department of Health and Human Services (HHS) issued a declaration of a public health emergency related to COVID-19 and mobilized the Operating Divisions of HHS2. In addition, on March 13, 2020, the President declared a national emergency in response to COVID-193. Therefore, FDA is taking urgent measures to protect consumers from certain products that, without licensure, approval, or authorization by FDA, claim to mitigate, prevent, treat, diagnose, or cure COVID-19 in people. As described below, you market a product that is intended to mitigate, prevent, treat, diagnose, or cure SARS or ARDS related to COVID-19 in people. We request that you take immediate action to cease marketing such unlicensed, unapproved, and unauthorized products for the mitigation, prevention, treatment, diagnosis, or cure of SARS or ARDS related to COVID-19.
Some examples of the claims on your website and social media websites that establish the intended use of your product include the following. Additionally, the second example misleadingly represents it as safe and effective for the treatment or prevention of COVID-19.
A YouTube video, titled "Stem Cells For COVID-19 . . . Lattice Biologics CEO injects himself with 1 million stem cells to test safety and efficacy," through which you market your amniotic fluid product." [from an April 2, 2020 YouTube video on your social media website www.youtube.com/watch?v=jyH85f9K-fk]
The YouTube video marketing your amniotic fluid product, in which you state that you "hop[e] that the stem cells can go in and repair [severe lung damage] . . . even if you are at the hospital . . . you have this lung damage this is a reasonable treatment to try and repair that . . ." [from an April 2, 2020 YouTube video on your social media website www.youtube.com/watch?v=jyH85f9K-fk]
Your representations that you are currently recruiting patients with "a laboratory confirmed infection with COVID-19 and evidence of lung involvement requiring supplemental oxygen or mechanical ventilation" to be administered "~ 5 million [stem cells] on the first day of enrollment and will receive another ~ 5 million stem cells on the second day of enrollment." [from your website www.latticebiologics.com/amnioboost-for-covid-19-clinical-study-recruitment/]
"NOW RECRUITING: Covid19 Patients for Free Clinical Trial. Lattice Biologics has begun enrolling patients in its Phase 1 clinical trial to address safety and efficacy of its novel stem cell technology." [from a March 20, 2020 tweet on your social media website www.twitter.com/latticebio]
"The Company . . . has decided to conduct the trial in Butte, Montana, and larger metropolitan areas as patients become available. The trial will not be conducted in hospitals, but rather in respiratory therapist offices . . . To date, the Company continues to enroll patients in Montana and is in negotiations with contract research organizations (CROs) to facilitate patient recruitment. Additional studies are expected to take place outside the U.S.; however, there are multiple companies and competitive trials underway for COVID-19, and patient recruitment is expected to be a significant hurdle to timeliness of studies." [from your May 11, 2020 "Lattice Biologics Update" found at https://www.businesswire.com/news/home/20200511005301/en/Lattice-Biologics-Update]
You should take immediate action to correct any violations of the FD&C Act, the PHS Act, and FDA's implementing regulations. This letter is not meant to be an all-inclusive list of violations that exist in connection with your product or operations4. It is your responsibility to ensure that you and your products fully comply with the law.
We advise you to review your website, social media websites, product labels, and other labeling and promotional materials to ensure that you are not misleadingly representing your product as safe and effective for a COVID-19-related use for which it has not been licensed by FDA and that you do not make claims that misbrand the product in violation of the FD&C Act. Within 48 hours, please send an email to COVID-19-Task-Force-CBER@fda.hhs.gov describing the specific steps you have taken to correct these violations. Include an explanation of each step being taken to prevent the recurrence of violations, as well as copies of related documentation. Failure to immediately correct the violations cited in this letter may result in legal action, including, without limitation, seizure and injunction.
FDA is advising consumers not to purchase or use certain products that have not been licensed, approved, cleared, or authorized by FDA and that are being misleadingly represented as safe and/or effective for the treatment or prevention of COVID-19. Your firm will be added to a published list on FDA's website of firms and websites that have received warning letters from FDA concerning the marketing or distribution of COVID-19 related products in violation of the FD&C Act5. This list can be found at http://www.fda.gov/consumers/health-fraud-scams/fraudulent-coronavirus-disease-covid-19-products. Once you have taken corrective actions to cease the marketing of your unlicensed, unapproved, and unauthorized product for the mitigation, prevention, treatment, diagnosis, or cure of COVID-19, and such actions have been confirmed by the FDA, the published list will be updated to indicate that your firm has taken appropriate corrective action.
If you cannot complete corrective action within 48 hours, state the reason for the delay and the time within which you will complete the corrections. If you believe that your product is not in violation of the FD&C Act, include your reasoning and any supporting information for our consideration.
If you are not located in the United States, please note that products that appear to be misbranded or unapproved new drugs are subject to detention and refusal of admission if they are offered for importation into the United States. We may advise the appropriate regulatory officials in the country from which you operate that FDA considers your product(s) referenced above to be unapproved and misbranded products that cannot be legally marketed to consumers in the United States.
Please direct any inquiries to FDA at COVID-19-Task-Force-CBER@fda.hhs.gov.
In addition, it is unlawful under the FTC Act, 15 U.S.C. 41 et seq., to advertise that a product can prevent, treat, or cure human disease unless you possess competent and reliable scientific evidence, including, when appropriate, well-controlled human clinical studies, substantiating that the claims are true at the time they are made. For COVID-19, no such study is currently known to exist for the product identified above. Thus, any coronavirus-related prevention or treatment claims regarding such product are not supported by competent and reliable scientific evidence. You must immediately cease making all such claims. Violations of the FTC Act may result in legal action seeking a Federal District Court injunction and an order may require that you pay back money to consumers. Within 48 hours, please send an email to Richard Cleland, Assistant Director of the FTC's Division of Advertising Practices, via electronic mail at rcleland@ftc.gov describing the specific actions you have taken to address the FTC's concerns. If you have any questions regarding compliance with the FTC Act, please contact Mr. Cleland at 202-326-3088 .
/S/
Mary A. Malarkey
Center for Biologics Evaluation and Research
Serena Viswanathan
Acting Associate Director
Division of Advertising Practices
1. As explained in a later paragraph, there is currently an outbreak of a respiratory disease named "Coronavirus Disease 2019" (COVID-19).
2. Secretary of Health and Human Services Alex M Azar, Determination that a Public Health Emergency Exists. Jan. 31, 2020. (Accessible at https://www.phe.gov/emergency/news/healthactions/phe/Pages/2019-nCoV.aspx). The declaration was renewed for another 90 days twice. The most recent renewal went into effect on July 25, 2020. Secretary of Health and Human Services Alex M. Azar II, Renewal of Determination that a Public Health Emergency Exists. July 23, 2020. (Accessible at https://www.phe.gov/emergency/news/healthactions/phe/Pages/covid19-23June2020.aspx).
3. President Donald J. Trump, Proclamation on Declaring a National Emergency Concerning the Novel Coronavirus Disease (COVID-19). Mar. 13, 2020. (Accessible at https://www.whitehouse.gov/presidential-actions/proclamation-declaring-national-emergency-concerning-novel-coronavirus-disease-covid-19-outbreak/).
4. For example, you also market your amniotic fluid product for intravenous administration to treat such diseases or conditions as Parkinson's disease, multiple sclerosis, and rheumatoid arthritis. [www.youtube.com/watch?v=jyH85f9K-fk]. Although these claims are not the focus of this letter, please be advised that you must have an approved BLA to lawfully market your amniotic fluid product for such indications, or you must have an IND in effect to distribute your product for such clinical uses.
5. We note this Warning Letter also concerns the marketing of a COVID-19 related product in violation of the PHS Act.
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Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis.
Myrianthopoulos, V., Gaboriaud-Kolar, N., Tallant, C., Hall, M.L., Grigoriou, S., Brownlee, P.M., Fedorov, O., Rogers, C., Heidenreich, D., Wanior, M., Drosos, N., Mexia, N., Savitsky, P., Bagratuni, T., Kastritis, E., Terpos, E., Filippakopoulos, P., Muller, S., Skaltsounis, A.L., Downs, J.A., Knapp, S., Mikros, E.
Bromodomains (BRDs) are epigenetic interaction domains currently recognized as emerging drug targets for development of anticancer or anti-inflammatory agents. In this study, development of a selective ligand of the fifth BRD of polybromo protein-1 (PB1(5)) related to switch/sucrose nonfermenting (SWI/SNF) chromatin remodeling complexes is presented. A compound collection was evaluated by consensus virtual screening and a hit was identified. The biophysical study of protein-ligand interactions was performed using X-ray crystallography and isothermal titration calorimetry. Collective data supported the hypothesis that affinity improvement could be achieved by enhancing interactions of the complex with the solvent. The derived SAR along with free energy calculations and a consensus hydration analysis using WaterMap and SZmap algorithms guided rational design of a set of novel analogues. The most potent analogue demonstrated high affinity of 3.3 μM and an excellent selectivity profile, thus comprising a promising lead for the development of chemical probes targeting PB1(5).
Department of Pharmacy, University of Athens , Panepistimiopolis Zografou, GR-15771 Athens, Greece.


text:
Dave Venable
Global and Cyber Security
Dave Venable is a former intelligence officer with the National Security Agency, with extensive experience in Computer Network Exploitation, Information Operations, and Digital Network Intelligence, and cryptography. He has also taught about these subjects while serving as adjunct faculty at the National Cryptologic School.
David has developed and managed several U.S. national-level projects in support of global anti-terrorism operations and the Global War on Terror, in addition to providing security consulting to Global 500 companies. David has also authored several cyber security articles, he regularly teaches classes on information security, and he has received numerous awards from the US Air Force, the National Security Agency, and the European Academy of Diplomacy.
David is a cyber security fellow with Strategikon, a European think tank focused on global security, and serves on the Cyber Security Advisory Board of Southern Methodist University. David is the Vice President of Cyber Security at Masergy Communications where he is responsible for protecting a global network infrastructure, as well as advising multinational companies about protecting their vital digital assets.


text:
CDC makes 'urgent' call to rein in opioid prescriptions
John Fauber and Crocker Stephenson
After more than 165,000 overdose deaths and a quadrupling of narcotic painkiller prescriptions in the last 15 years, the U.S. Centers for Disease Control and Prevention issued a new guideline Tuesday designed as an "urgent response" to rein in the prescribing of opioids for chronic pain.
"We know of no other medication routinely used for a nonfatal condition that kills so frequently," CDC Director Tom Frieden said.
More than 40 Americans die each day from prescription opioid overdoses, he said.
"We must act now," Frieden said. "Overprescribing opioid, largely for chronic pain, is a key driver of America's drug-overdose epidemic."
Since the CDC does not regulate medicine, the new guideline is not binding, but it encourages physicians and patients to talk and make informed decisions while strongly discouraging the use of opioids as a first choice for chronic pain.
The action comes on the same day that the Milwaukee County medical examiner's office released data showing that a record high 255 people died of drug overdoses in 2015, an increase of 53% from 2012.
These are deaths from exposure to a multitude of drugs, often combined, and not merely the focus of the CDC guidelines: narcotic painkillers. Nonetheless, more than half the deaths — 178 — involved prescription drugs, including alprazolam, diazepam, hydrocodone and morphine.
Heroin overdoses —109 — approached nearly half of all drug deaths.
Fentanyl, which is used to put patients under for surgery and to alleviate pain, killed 30, an increase of 500% from 2012. The county has seen a rash of fentanyl deaths since the first of the year.
The youngest to die of a drug overdose in Milwaukee County was 2 and the oldest was 72. The average age was 42.7.
Three key principles
The CDC guideline was published Tuesday in JAMA. It includes 12 recommendations based on three principles that are key to improving patient care:
■ Non-opioids are preferred for chronic pain outside active cancer, palliative and end-of-life care.
■ When opioids are used, the lowest possible dose should be prescribed.
■ Doctors should exercise caution when prescribing and monitor all patients closely.
"The guidelines are a very big deal...mainly because the medical community holds CDC in high regard and takes its recommendations seriously," said Andrew Kolodny, an addiction specialist and longtime critic of the opioid industry and the federal government's failure to curtail the use of opioids.
In Journal Sentinel/MedPage Today investigations pain experts have criticized another key federal agency, the Food and Drug Administration, for its cozy relationship with the opioid industry and its ongoing approval of new narcotic painkillers despite a growing number of overdose deaths and booming prescriptions.
In an emailed statement, FDA spokeswoman Sarah Peddicord said the agency supports the CDC guideline "as another important step forward in the federal effort to address this urgent public health crisis."
Under new commissioner Rob Califf, she said, the agency is re-evaluating its approach and policies regarding opioids.
She added, "We are deeply concerned about the growing epidemic of opioid abuse, addiction. ...There is no one cause of this public health crisis and there will not be one action, or institution, that will solve it."
The Journal Sentinel/MedPage investigations also showed that behind the surge in prescribing was a network of pain organizations, doctors and researchers that pushed for expanded use of the drugs while taking in millions of dollars from the companies that made them. One of those groups was the University of Wisconsin Pain & Policy Studies Group.
Doctor-driven epidemic
In a teleconference, Frieden said the opioid epidemic is doctor driven and can be reversed by doctors. Primary care doctors write about half those prescriptions.
Frieden acknowledged that doctors are under pressure to prescribe painkillers for fear of getting a bad review on Yelp or being criticized for not meeting expectations for taking chronic pain seriously. A whole generation of doctors went through medical school being told that prescribing opioids would not lead to addiction, he said.
He said that treating chronic pain is an art and science, but with opioids the risks are addiction and death and the benefits are transient and unproven.
Even for acute pain, such as after returning home from minor surgery, three days of painkillers usually is sufficient and more than seven days is rarely needed, he said.
In a study accompanying the guideline, researchers found that 42% of people who had a tooth extracted filled an opioid prescription within seven days. Among patients age 14 to 17 years it was 61%.
"This common dental procedure may represent an important area of excessive opioid prescribing in the United States," the researchers wrote.
Another study looked at four low-risk surgical procedures: carpal tunnel release, laparoscopic gallbladder removal, hernia repair or knee arthroscopy. Within seven days, 80% of the patients filled a prescription for an opioid.
The average dose increased over time for all procedures, including an 18% increase for patients undergoing knee arthroscopy.
"Further research should assess the contribution of postoperative opioid prescribing practices to the epidemic of prescription opioid-related abuse," the researchers wrote.


text:
Michael J. McCord
Under Secretary of Defense (Comptroller)/Chief Financial Officer
The Honorable Mike McCord was sworn in as the Under Secretary of Defense (Comptroller)/Chief Financial Officer on June 1, 2021. He is the first person to be confirmed twice for this position.
Immediately prior to his confirmation he served as the Director, Civil-Military Programs at the Stennis Center for Public Service, as an adjunct researcher at the Institute for Defense Analyses, and as a member of the Board of Trustees of the Aerospace Corporation. In 2017, he was appointed to the congressionally mandated Commission on the National Defense Strategy for the United States, which released its report Providing for the Common Defense in November 2018.
From January 2009 through January 2017 he served at the U.S. Department of Defense as the Under Secretary of Defense (Comptroller)/Chief Financial Officer and before that as the Principal Deputy Under Secretary of Defense (Comptroller). He was nominated by President Obama and confirmed by the U.S. Senate for each of these positions. In these roles he advised Secretaries of Defense Bob Gates, Leon Panetta, Chuck Hagel and Ash Carter on all budgetary and financial matters and was responsible for development and execution of annual defense budgets in excess of $550 billion.
Prior to his service at the Department of Defense, Mr. McCord served for 24 years in the legislative branch, including 21 years as a Professional Staff Member on the Senate Armed Services Committee (SASC) for former Senators and Chairmen Sam Nunn and Carl Levin. As a member of the Senate staff his primary focus was on budget, fiscal policy, and military readiness and installation issues. Mr. McCord also served on the staff of the House Budget Committee as an analyst on defense and veterans programs, and as a cost analyst at the Congressional Budget Office.
Mr. McCord has a B.A. with honors in Economics from the Ohio State University and a Master of Arts in Public Policy from the University of Pennsylvania, and is a Fellow of the National Academy of Public Administration.
All Biographies


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Karl Thiele (* 16. Oktober 1867 in Hannover; † 6. September 1940 ebenda) war ein deutscher Tischlermeister und Wassersportler. Er gründete "vermutlich den ersten Kanu-Club Deutschlands überhaupt" und gilt als Ideen-"Vater des Maschsees".

Leben
Karl Thiele wurde als Sohn eines Tischlers geboren, absolvierte selbst eine Tischlerlehre und schloss mit dem Meistertitel ab. Im selben Jahr begann er – "besessen" vom Wassersport – mit dem Bootsbau aus Brettern der Tischlerei seines Vaters.

Mit gerade einmal 16 Jahren gründete Thiele gemeinsam mit sechs Freunden am 29. November 1883 den Sportverein Hannoverscher Canoe-Club. Doch es kam zu Schwierigkeiten mit den orthodox-strengen Ruderern – 1885 wurde der Club umbenannt in Hannoverscher Ruderverein Triton.

1903 hatte Thiele erstmals die Idee zum Bau eines Sees in der Aegidienmasch, gründete 1904 die "Maschsee-Kommission".

Aus diesem Verein heraus gründete Karl Thiele den heutigen Hannoverschen Kanu-Club von 1921 (HKC) mit Sitz im Glocksee-Viertel, nahe dem Lokal Justus Garten am Zusammenfluss der Leine und der Ihme.

Karl Thiele saß 17 Jahre im Vorstand des HKC, war 5 Jahre Erster Vorsitzender und wurde 1935 zum Ehrenmitglied ernannt. Doch schon zuvor hatte das Bürgervorsteherkollegium noch 1932, in der Weimarer Republik, den Bau des Maschsees beschlossen, als Thiele mehr als ein Vierteljahrhundert nach seiner ersten Idee den Beginn der Bauarbeiten erleben konnte: Am 21. März 1934, dem durch die Nationalsozialisten so genannten "Tag der nationalen Arbeitsschlacht", begann der Bau, anfangs mit nur 100 Arbeitslosen, später mit mehr als 1.650 Menschen.

Thiele leitete zeitweilig auch die Kanu-Riege des Hannoverschen Ruder-Clubs von 1880 (HRC), der ehedem ebenfalls an der Glocksee beheimatet war (in der Glockseestraße) und 1936 seinen Sitz an den Maschsee verlegte.

Weitere Ehrungen
 1940 wurde Karl Thiele mit der Goldenen Nadel des Deutschen Ruderverbands ausgezeichnet.
 Um 1936 entstand beim Bau des Maschsees ein Weg vom (heutigen) Rudolf-von-Bennigsen-Ufer in der Südstadt bis nach Waldhausen; dieser Weg wurde laut dem Adressbuch der Stadt Hannover von 1958 im Jahr 1957 als Karl-Thiele-Weg benannt.
 Auf dem Gelände des HRC am Karl-Thiele-Weg 20 wurde ein Karl-Thiele-Gedenkstein aufgestellt.

Literatur
 Lothar Wieser (Redaktion): Sport in Hannover. Von der Stadtgründung bis heute, hrsg. vom Niedersächsischen Institut für Sportgeschichte, Hoya e.V., Wissenschaftlicher Beirat, Hoya:  Niedersächsisches Institut für Sportgeschichte, 1991, ISBN 3-923478-56-9, S. 252
 Dirk Böttcher: THIELE, Karl. In: Dirk Böttcher, Klaus Mlynek, Waldemar R. Röhrbein, Hugo Thielen: Hannoversches Biographisches Lexikon. Von den Anfängen bis in die Gegenwart. Schlütersche, Hannover 2002, ISBN 3-87706-706-9, S. 358.
 Dirk Böttcher: Thiele, Karl. In: Klaus Mlynek, Waldemar R. Röhrbein (Hrsg.) u. a.: Stadtlexikon Hannover. Von den Anfängen bis in die Gegenwart. Schlütersche, Hannover 2009, ISBN 978-3-89993-662-9, S. 621f.

Einzelnachweise

Kanus
Sportgeschichte (Deutschland)
Sport (Hannover)
Kanute (Deutschland)
Person (Hannover)
Schiffbauer
Deutscher
Geboren 1867
Gestorben 1940
Mann

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text:
O ataque ao engenho Tracunhaém, também conhecido como tragédia de Tracunhaém ou chacina de Tracunhaém foi um ataque de índios potiguaras dirigido ao Engenho Tracunhaém, próximo a Goiana, Pernambuco, ocorrido em 1574. Neste ataque, toda a população colonizadora da região foi dizimada.

Contextualização
Depois do descobrimento do Brasil pelos portugueses, nas terras ainda por serem ocupadas, transitavam piratas e corsários, traficantes de pau-brasil. Estes traficantes eram, na sua maioria, franceses, que, logo, estabeleceram, com os índios, uma relação de escambo: em troca da extração do pau-brasil, os índios recebiam objetos considerados sem valor pelos franceses, como espelhos, pentes, tesouras, dentre outros.

Para explorar as terras, a Coroa portuguesa dividiu o país em capitanias hereditárias, porções de terra administradas por um só dono, que tinha poder sobre tudo que acontecia dentro desta. Em 1534, D. João III doou a capitania de Itamaracá a Pedro Lopes de Sousa. As suas terras iam desde a foz do rio Santa Cruz (hoje rio Igaraçu) em Pernambuco, até próximo ao rio Paraíba, que, nessa época, chamava-se São Domingos. A administração da capitania coube a Francisco Braga, que rivalizava com Duarte Coelho. Francisco Braga, no entanto, levou a capitania à falência. Foi substituído por João Gonçalves, que desenvolveu engenhos e fundou a Vila Conceição.

A Tragédia de Tracunhaém

Um mameluco chega até a Aldeia dos Potiguares - região onde hoje é a Paraíba - e lá é muito bem recebido por todos, inclusive pelo Chefe que comandava a Tributo: o índio Iniguaçu. Uma das filhas deste chave, a índia Lábios de Mel, foi autorizada a casar-se com o mameluco que ali chegara, porém deveria cumprir a ordem de permanecer na tribo.
Desobedecendo a ordem do Chefe Indígena Iniguaçu, o mameluco foge levando consigo a índia Lábios de Mel - filha do Chefe. Após este ato de desobediência, Iniguaçu ordena que seus filhos homens saiam à procura da sua irmã. Durante a viagem de busca, estes irmãos precisam parar para repousar, achando abrigo, então, no Engenho pertencente ao português Diogo Dias - próximo ao Rio Tracunhaém. Enquanto durava o pernoite, os irmãos de Lábios de Mel tiveram contato com alguns franceses, os quais relataram que o proprietário do Engenho, o Senhor Diogo Dias, estava sob posse da índia e não a devolveria. Munidos desta informação, os irmãos retornam à sua tribo e reúnem consigo 2.000 (dois mil) indígenas e partem para tomar - forçadamente - a sua irmã que fora levada.
Chegando ao engenho, os indígenas, estrategicamente, esconderam-se de modo que não se poderia aferir que o número de homens era tão elevado. Ao avistar apenas alguns indígenas, os guardiões do engenho partiram para luta; após isso, de maneira surpreendente, os indíos que estavam escondidos surgiram - revelando sua grandiosidade numérica - e atacaram, mediante surpresa, os portugueses. Deste ataque, ninguém da família de Diogo Dias escapou com vida. No massacre foram mortos familiares, trabalhadores do engenho, guardiões das terras e também escravos. Estima-se que nesta noite os Potiguares matem 614 pessoas, num episódio que hoje é conhecido por: Tragédia de Tracunhaém.

Veja mais
 História da Paraíba
 Capitania de Itamaracá

Ligações externas

História de Goiana


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text:
Hunting February 28, 2022
South Africa releases endangered animals for shooting – to help the poor
From Magazin "Der Spiegel": 02/26/2022
The South African government allows hunting of endangered species – including black rhinos, which are classified as critically endangered. The proceeds will go to impoverished villages.
South Africa has cleared a number of endangered species for shooting.
"A total of 10 black rhinos and 150 elephants can be hunted," said the country's Ministry of Forests and Environment.
Some leopards will also be shot under certain circumstances.
Proceeds from the sale of hunting licenses go to impoverished rural communities in the hunting areas.
Black rhinos are listed as critically endangered by the International Union for Conservation of Nature.
The number of animals in the wild had recently doubled from an all-time low three decades ago to more than 5,000.
The ministry said the quota allocated was based on population estimates "which are currently trending upwards."
In 2014-2017, black rhino poaching had increased dramatically.
On average, 1,000 animals per year were illegally killed during this period. However, the problem could be contained.
Last year, 451 black rhinos were illegally killed.
The official hunting quota for elephants has been set in accordance with international laws on trade in endangered species, the ministry said.
The elephant population is growing (!!!) and 150 animals is less than 0.3 percent.
According to the ministry, hunting of leopards is limited to animals over the age of seven (!!!) and only in regions where the populations are "stable or increasing".
https://www.spiegel.de/panorama/umstrittene-grosswildjagd-suedafrika-gibt-seltene-tiere-zum-abschuss-frei-a-f934924f-4524-4d83-9a3d-498c846bbf23
And I mean…If a hunter buys such a license, can the animal stay alive?
No! because the hunter wants something for his money, namely satisfying the desire to end a life.
This is blood money.
There has never been a worse excuse to legitimize hunting and poaching.
This is an excuse to bring rich big game hunters into the country.
Any Saudi prince or son of American politicians will take great pleasure in pulling the trigger.
Or can the old king of Spain do it again…
What a disgusting perversion…
Nobody has lost anything in the habitats of these animals.
Rhinos defend their calves should someone get too close to their habitat.
Elephants and leopards too, by the way.
Because humans don't respect their habitats and rob them, the simplest "solution" always comes up: shoot them down.
Shame on South Africa!
The goal must be for Africa to benefit from its biodiversity and intact nature without destroying it.
And quite frankly now: if a country like South Africa isn't even able to help these impoverished regions without shooting down these endangered animals, then something suspicious is afoot
28/2/22 – More Ukraine Links.
The Munich Philharmonic is now Russian free!!


Prairie Mining confirmed that it would consider taking legal action against the Polish government over resistance to its coal development plans.
'Praire's notification calls for prompt negotiations with the government to amicably resolve the dispute, and indicates Prairie's right to submit the dispute to international arbitration in the event the dispute is not resolved amicably,' Prairie said.
Dual-listed Prairie Mining said it had requested a suspension of trading of its shares on the Australian Securities Exchange pending a significant announcement.
Prairie Mining confirmed that it was still talking to Jastrzębska Społka Węglowa concerning a possible deal related to its Polish coal projects.
Prairie Mining said a quality analysis had indicated its Jan Karski Mine in Poland was a 'globally significant' semi-soft coking coal deposit.
Beaufort Securities today reaffirms its buy investment rating on Prairie Mining Ltd (LON:PDZ) and set its price target at 90p.


text:
The call to the tech companies is part of an "action plan" on fake news | Joel Saget/AFP via Getty Images
EU to ask Facebook, Twitter, Google for monthly 'fake news' reports
The call to the tech companies is part of an 'action plan' on fake news.
By	Laurens Cerulus
12/4/18, 3:27 PM CET
The European Commission is planning to ask social media platforms including Facebook, Twitter and Google for monthly reports on Russian disinformation campaigns ahead of the European election next May, two EU officials told POLITICO.
The call to the tech companies is part of an "action plan" on fake news, expected to be presented Wednesday.
Facebook and others will be asked to provide reports from January to May, one official said. The information would be compiled by the European Commission, which is also planning to publish these reports to create awareness among European voters on how foreign actors try to influence their vote.
Wednesday's action plan would single out Russia as a repeated offender using systematic, large-scale disinformation campaigns.
The tech companies' reports would include figures on how they label political adverts as well as how many bot accounts and fake accounts they identify and disable.
Companies that have signed up to the EU's Code of Practice on Disinformation would be asked for monthly reporting. So far, individual companies that have signed up include Google, Facebook, Twitter and Mozilla.
The Commission's action plan would include a request for more funding for disinformation agencies in Europe, including the EU's own StratCom unit in the External Action Service, and the creation of a "rapid alert system" to notify national authorities if the country is under a sustained attack of fake news.
Facebook confirms Sandberg directed staff to research Soros' financial activity
Cristiano Lima
Global lawmakers turn up heat on Facebook
Laurens Cerulus
lcerulus@politico.eu
Twitter suspends account of Poland-backed French far-right website
France Libre 24 suspended for violating social media site's spam policy.


[JRASERVER-8943] WYSIWYG / Rich Text Editor - Create and track feature requests for Atlassian products.
We're pleased to announce that the new rich text editor will be available in the upcoming release of JIRA Server 7.2.
We are still working on providing a great, modern text editor for JIRA Cloud with a consistent user interface across all of Atlassian Cloud, including Confluence Cloud, Bitbucket Cloud, and HipChat. We will continue to provide updates on this issue when we are farther along on bringing the new text editor to JIRA Cloud.
Now that JIRA supports wiki markup, it would be nice if there is a WYSIWYG/Rich Text editor for JIRA (similar to the one in Confluence).
JRASERVER-30423 Allow "auto-generated" links to cross JIRA instances.
JRASERVER-8175 WIKI markup doesn't let me over-ride text formatting.


text:
Q: What am I doing wrong in Orientrom? I am using module orientorm which i downloaded from github (https://github.com/mav-im/orientorm)
and I also add come lines of code in ./lib/index.js after line No. 23
this.Scehma = require('./dbSchema');
this.Model = require('./model');
this.Query = require('./query');

So that I can use other modules. I search on google for help. But I can not find any content about ur module.
Here is my code
orientorm = require('orientorm'),
orntSchema = orientorm.Scehma;

var UserScehma = new orntSchema({
  created: {
    type: Date,
    default: Date.now
  },
  title: {
    type: String,
    required: true,
    trim: true
  },
  content: {
    type: String,
    required: true,
    trim: true
  },
  user: {
    type: orntSchema.Types.Link,
    ref: 'User'
  }
});

orientorm.Model('UserScehma', UserScehma);

But I got this error...
.\lib\model\
    this.$__.strictMode = schema.builtOpts && schema.builtOpts.strict;
                                ^
TypeError: Cannot read property 'builtOpts' of undefined
    at Orientorm.Doc (D:\orientrom_app_prec_1\node_modules\orientorm\lib\model\Document.js:35:33)
    at Orientorm.Model (D:\orientrom_app_prec_1\node_modules\orientorm\lib\model\index.js:13:7)
    at Object.<anonymous> (D:\orientrom_app_prec_1\app.js:27:11)
    at Module._compile (module.js:456:26)
    at Object.Module._extensions..js (module.js:474:10)
    at Module.load (module.js:356:32)
    at Function.Module._load (module.js:312:12)
    at Function.Module.runMain (module.js:497:10)
    at startup (node.js:119:16)
    at node.js:906:3

redpajama_set_name: RedPajamaStackExchange


Discuss your case with an Irvine divorce mediation attorney! Call (714) 706-3992.
If going to court is the usual route couples take, why pursue a cooperative divorce? What are the benefits? These are questions our staff members hear all the time at Center for Mediated Divorce (CMD). At CMD, we are committed to helping you understand the advantages of a cooperative divorce, while also providing you with the support you need to make the right decision for you and your family. Our Irvine divorce mediators encourage cooperative divorce when one or both parties prefers to have his or her own attorney. The Cooperative Divorce Group is a group of select Orange County attorneys who are very experienced and skilled at guiding clients to cooperative settlements and other divorce solutions. The clients and their respective attorneys meet together and cooperatively deal with each issue and craft a negotiated agreement.
You can communicate with your spouse without igniting a war.
It's focused on the solution, not the problems.
The emphasis is placed on coming up with constructive settlement negotiations.
It's more affordable and won't be dragged out in court.
The process is informal and flexible.
You are more committed to abiding by a plan that you helped to create.
You are in the driver's seat making the decisions about your family, not a judge.
It allows couples to have a civil and respectful post-divorce relationship.
We genuinely believe that a cooperative divorce can benefit everyone involved. If you would like to avoid a costly, high-conflict divorce, we encourage you to contact our legal team at (714) 706-3992 and discuss divorce alternatives!
We believe it is possible to emerge from a divorce with your privacy and dignity still intact. CMD is prepared to put over two decades of legal experience to work for you today!
If you would like to explore whether cooperative divorce is the right option for you, feel free to schedule a case evaluation.
Is Cooperative Divorce Right For You?
"She got me everything I asked for so that I could ..."
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A wonderful nervine, great for uplifting the mood and alleviating depression, rose also has antispasmodic, aphrodisiac and sedative qualities, as well as being anti-inflammatory. Rose helps regulate menstruation as well as stimulate the digestion.
Use rose topically or internally to calm inflammation. Rose has a cooling effect on the body, making it great for any irritation that involves heat and redness- think rashes, itching, sunburns, bug bites, etc. Great for sore throats, burns, and general pain, rose-infused honey, rose glycerite, rose tincture, and rose salve, can provide effective pain relief. Rose relaxes and soothes the liver, rather than stimulating it. This is very useful when faced with hepatitis.
Roses are associated with Aphrodite, Adonis and Eros.
Rosewater is a protective agent worn on clothes.
Rose petals can be added to charms against the evil eye.
White roses worn at weddings will bring happiness and security to the couple.
Roses are used traditionally in love spells. It is great in incense and potpourri. Thorns can be used to mark wax figures.


text:
Sixième Sens Collection by Cartier
Posted By Sandra Bauknecht On June 24, 2021 @ 2:47 pm In All,Celebrities,Jewelry,Objects of Desire | Comments Disabled
The new SIXIÈME SENS COLLECTION by CARTIER illustrates the soulfulness particular to high jewelry, an expression of art with the power to move like no other.
With a stylised feline interpretation, organic textures and shards of coloured light, shimmering gems electrify while stones in flavoursome hues of ripe fruits summon up scents of distant paradises.
Using trompe-l'œil and graphic patterns, optical illusions and the power of evocation, compositions play with earthly gravity in radiant transfigurations of reality. Quivering in the light, jewels come to life upon contact with the skin.
Accomplished actress, singer and musician, Golshifteh Farahani, is the ambassador of this amazing high jewelry collection. This multi-hyphenate creative moves with ease between arthouse films and Hollywood productions, spanning the course of her 20-year career. She has made her mark on the red carpet, where she is known for her style and elegance.
PHAAN RING
How do you add to the beauty of an 8.20 carat ruby? How do you enhance that which is already exceptional? Behind the architecture of this ring is a tiered construction that allows a 4.01 carat rose-cut diamond to be inserted directly below the magnificent stone that sits at the top. When the light hits the diamond after first passing through the ruby, its rich red hue is intensified.
The structure integrates groups of triangular diamonds while maintaining the ring's airy appearance. Along with tiny ruby balls, diamonds surround the central stone, arranged with subtle openings to allow them to catch the light, illuminating the ruby.
MERIDE NECKLACE
The purity of the motif is also its strength. The stones appear to multiply ad infinitum an optical illusion that is made all the more striking by the relief of the piece as each element is mounted at a different level. Movement, rhythm, and all spatial and temporal references are lost in a precious mosaic of gemstones. The blurring of perspective is complemented by a play of materials and light between mirror-polished metal and graphic black onyx.
As always with Cartier, particular attention has been paid to the back of the piece, which reveals the exact reverse of the front.
PIXELAGE NECKLACE
This necklace conjures up the familiar image of the panther, so dear to Cartier, borrowing both its markings and symbolic power. A stylised play on the feline's coat has been part of Cartier's artistic bestiary since 1914. Faithful to the original stylisation, here, motifs make up the panther's spots. Polished onyxes evoke the marbling of the fur, while white, yellow and orange diamonds represent the thickness of the pelt, with its golden reflections highlighted by three captivating golden topazes for a total of 27.34 carats.
Attention to the volume and articulation of the sides allows the construction to respect the vertical geometry of the collar, while preserving its flexibility.
PARHELIA RING
At its centre lies a 21.51-carat sapphire cabochon, with an intense blue hue which seems to glow from within. Around it, five parentheses of radiant diamonds and emeralds reflect the light, fanning out like the surface of a lake. Black lacquer creates shadow effects to reinforce the impression of movement, supported by the original width of the ring, which spans three fingers, with slightly mobile tips.
As an ultimate refinement, the motif can be detached and worn as a brooch.
Created at the very beginning of the 20th century, this combination of sapphires and emeralds, named the «peacock motif» by Louis Cartier, is part of the Maison's emblematic colour palette.
ALAXOA NECKLACE
The captivating texture and chromatic intensity of this necklace belie the rigorous and precise approach of its inception.
After selecting the emeralds according to their colour and diameter, artisan jewellers carefully considered harmony, symmetry and correct placement in the composition, before assembling using the threading technique—an expertise rooted in the Maison's savoir- faire which consists of threading the stones on a wire to form strands and fringes. Finally, the strands are linked together by tiny metal bridges, maintaining a fan shape while allowing the fringes to remain mobile.
SHARKARA NECKLACE
With a balance of straight lines and curves, the design of this piece highlights its ample and generous volume. Considered as a whole, the necklace evokes an organic shape, ripe with succulent berries.
Elaborating a colour palette as such requires total gemological mastery, while the discreet tourmaline settings and attention to detail—right down to the shape of the garnets cut to reflect curves of the piece— reveal the workshop's expertise.
CORUSCANT NECKLACE
A vibrant testament to the enchanting power of diamonds, this necklace features six different cuts—kite, octagonal, emerald, triangle, baguette and brilliant— certified D IF and E IF, each of which reflects light from a unique angle. Characterised by rigorous geometry, the necklace is entirely structured by an interplay of lines, with three stones—a kite of 3.00 carats, an octagon of 1.62 carats, and an emerald of 1.54 carats—emerging from brilliant interlacing to catch the eye.
The chain resembles a tight braid of gemstones, creating a path of light leading to the trio of diamonds. On the outside, brilliant-cut diamonds appear to slip underneath the inclination of the baguette- cut diamonds, radiating from the top thanks to the graphical effect of motif repetition.
Photos: © Cartier
URL to article: https://www.sandrascloset.com/sixieme-sens-collection-by-cartier/


Stress is ignored so much in our life and sometimes it seems normal to be stressed out. Stress to me is an everyday affair if you think of the events that upsetting to you or your loved ones and even your animal friends. All people and animals friends can discover each day what we are generating from our energy fields or spiritual signatures. The bottom line is that just about everything that is not a common factor with each individual becomes stress from our environment.
Western civilization really got off to a wrong start by adopting the idea from Descartes for many years since he taught that the body is here and the mind is there, and one does not affect the other. We know that is a mistake now since everything the mind does affect the body. Studies have shown a very high measurement of stress in the years shortly before the development of cancer. Just a few years ago a major story on stress indicated researchers who were quoted as saying, "It is as if the immune cells themselves were expressing grief." The human body is such an intricate piece of work that it is necessary for it to operate as a wheel of balance: just like the web of life and circle of life ( Hoop of Life). Studies were done on dental students before an exam and the white blood cells of the stressed subjects had significantly reduced function to fight infections.
We know that stress is intimately involved with higher stomach acid levels (ulcers), higher adrenaline levels (hypertension and heart disease, faster heartbeat), reduced hormone function, and now it is said to accelerate wrinkles in the face (faster aging). You still want to be stressed out; let's not worry so much about things that we cannot alter in our family or walk through life.
Oriental or other medicine teaches the same concepts. Each organ/meridian system is connected to a particular emotion. Pathological emotions can lead to pathology in the organ/median system. Heart – joy (excess or lack of), Liver – anger or depression, Gallbladder – rage (hence the term, green with envy, green bile), Lungs and large intestine – grief, Kidney and bladder – fear.
Some other versions or theories on how this all works is that every cell in the body is in one way or another connected to the nervous system (The great circle of balance). For our immune cells then they are thought to be a direct extension of the nervous system. Although there's no fixed wiring to the brain, immune cells carry receptors on them identical to receptors in the brain. Body cells all have nerve endings adjacent to them etc. Stress can alter the output of the nerves causing aberrations in the information they give to target cells. Every cell in the human body has an electrical charge across the cell. This is why the researchers said that it seemed that the cells were communicating with each other. I think that we can meditate and move our energy fields to communicate with our cells thus diverting diseases from our bodies.
(1). Never feel irrational guilt. When you've done something to cause guilt, deal with it appropriately. But if you haven't done anything wrong and still feel guilty, you need to change the way you are looking at the situation.
(2). Never blame others (it provokes irrational guilt in them).
There is only one thing that we take to our grave – our body. Think it does anyone any good to take negative thoughts about another person or ourselves to the grave? No. What will help the other person is unconditional forgiveness and love. And of course, that is exactly what we need for complete inner healing. Stress cannot compete with love.
There is an old saying: As I think, I am. If you really think of this; then it is true to form or accurate. When we hold emotions and feelings in then they get held in a particular area of the body, affecting the local nervous system and causing deterioration. (Stress). Physical as well as emotional trauma and scars can be held in by the body for years. What you are harboring in your subconscious mind can also affect what diseases you have in your physical body. Arthritis, rigidity in the body, is seen as inflexibility in the personality of the individual. This has said to be a proven fact. Cancer, a disease that eats out the body, also very often represents something that is eating out the mind. Something eating out the mind must eventually take a toll on the human body since the body and mind are one. Scientific studies have studied this and confirm it.
I cannot at this time list all the research showing how the mind and body are intertwined or list all the ways our lives are affected by mind, body or spirit. One human does not exist well without the other and each is dependent on the other. I would encourage meditation, and if spiritual, prayer, or any technique that will help an individual quiet the overactive mind. It is up to us to learn from our diseases we have, what it is trying to tell us, and when we have learned then we don't need it anymore since it has done damage on our lives and most of the people around us. (Stress). Unconditional love and forgiveness, letting go of the past, living in the present, and moving toward the future, as taught by masters of old, is the best advice anyone can take at heart.
Bilberry: Helps prevent destruction, mutation, and premature death of cells throughout the body.
Gingko Bilbao: Helps to aid in proper brain function and good circulation.
Milk Thistle: Cleanses and protect the liver, and has antioxidant properties. (Most effective if taken in capsule form).
Catnip: An effective anti-stress herb that also causes drowsiness.
Chamomile: A gentle relaxant. It is a good nerve tonic, soothing to the digestive tract, and a pleasant sleep aid. (Caution: Do not use this herb on an ongoing basis and avoid it completely if you are allergic to ragweed).
Hops: Helps to ease nervousness, restlessness, and stress. It also decreases the desire for alcohol.
Passionflower: Is calming and is a potent addition to any anti-stress formula.
St John's Wort: Is good for depression and nerve pain.
Skullcap: Is good for nervous disorders. It also relieves headaches and aids sleep.
Valerian: Keeps the nervous system from being overwhelmed. It also is a powerful sleep aid when taken at bedtime and helps to ease stress related headaches.
This information is for educational purposes only. It is by no way intended to treat, diagnose, or cure any type of disease or ailments. When taking alternative medicine, herbs, or supplements always consult your health care provider or physician before using them.
May we all always strive to walk in the spirit; respecting the Creator and thanking Mother Earth for giving us our bountiful supplies of medicinal herbs.


text:
45 is an Unlucky Number
With the exception of Kat Myrman'sTwittering tales once a week, I am not a fan of reblogging the work of others. I especially resist material that mentions the Travesty in Chief currently disguising himself as a member of the human race. (NOTE: "himself" is used here as correct with a deferential nod to the political correctness people. Anybody want to demand inclusion in the trainwreck to which "he" belongs)?
This Ode points out the warts that surface as temporary occupants of the house in the swamp interpret their role while exercising great power. It might even encourage some to look back in history and see how people, like us, reacted at the time and tried to cope with an imperfect system. Those were different times, unlike now when people, like us, are apathetic and willing to accept all kinds of public indecencies; physical, ethical, and moral.
If history can be viewed as a pendulum swinging from one extreme to another, I think the arc of that swing has become wider over time. I look at the turbulent '60s when people were involved on both sides of efforts to end a war and bring down a corrupt leader. Now, with a younger crowd living in the basements of parents from that same generation, we have no involvement to end many wars and bring down a leadership that defines corruption.
Where did we (the people) go?
Ode to Presidents Day
On this winter day, we honor the presidents,
All of the Oval Office's residents.
All 45 of them, each one a man
Who held the highest office in the land.
We pay homage today to the best and the worst,
Georges 41 and 43, as well as George the First.
Honest Abe Lincoln, who could not lie.
William Henry Harrison, who after one month would die.
Hoover, who was haunted by the Depression.
Truman, who left a lasting impression.
Obama, noted for his eloquence.
Coolidge, remembered for his silence.
Ike, whose wartime exploits made him shine.
Nixon, whose coverup led him to resign.
We remember the Adamses, father and son,
And the writings and deeds of T. Jefferson.
Andrew Johnson and Clinton were impeached,
But the final verdict was favorable to each.
FDR, who steered us through World War II.
Jack Kennedy, whom we hardly knew.
Gerald Ford, oft lampooned on Saturday Night Live.
Jimmy Carter, the oldest "ex" still alive.
They and the others all did their best.
But the current occupant does not pass that test.
He tweets and he golfs while his family earns.
He won't let us see his tax returns.
He shut down the country over a wall,
His hands and his brain are freakishly small.
Let's hope that one of the Democrats' picks
Will be elected next year to become 46.
Origiinal post at https://exjournalistsunite.wordpress.com/2019/02/18/ode-to-presidents-day/#like-26317
Follow their website for different views on the current National Emergency that is POTUS.
Tags: not a book review
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Apologies to My Muse


Republican presidential candidate Donald Trump sued the registrar of voters in Clark County, Nevada, over a polling place in Las Vegas that had been allowed to remain open late last week to accommodate people who were lined up to vote.
Trump and Democrat Hillary Clinton are in a close contest for Nevada's six electoral votes in Tuesday's election after a long and contentious campaign. Nevada is one of several states that permits early voting and Las Vegas is viewed as a base of support for Clinton.
Nevada state law says voters who are in line at 8 p.m., when the polls close, must be allowed to cast their ballots.
Trump's lawsuit, filed in a Nevada state court on Monday, said election officials violated state law because they allowed people to join the line after 8 p.m. at a polling location at a Latino market.
Trump, who said last month that he might not accept the outcome of the national election if he thinks it is unfair, asked in the lawsuit that the ballots from the Latino market be kept separate from other votes, pending any legal challenges to the state's results.
"We have to keep the system honest," Trump, a New York businessman and reality TV personality who has never previously run for political office, said on Fox News.
Clark County spokesman Dan Kulin said the lawsuit asks the county to preserve records, "which is already required by law for us to do that." Representatives for the Clinton campaign could not be reached immediately for comment on the lawsuit.