text:
A Worse Slaughter
Blair makes much of 'humanitarian values' but sells arms to Indonesia which are used against East Timor.
The indictment of Milosevic is good news. The crimes he and his gang have committed make him a first class war criminal. However, try as he may, he has yet to approach the record set by the Indonesian dictator Suharto.
According to a study commissioned by the Australian Parliament, "at least" 200,000 East Timorese have died as a direct result of the Indonesian invasion and occupation. That is a third of the population or, proportionally, more people than were killed by Pol Pot in Cambodia.
When I travelled through the Matabean mountains of East Timor, beneath endless silhouettes of black crosses etched against the sky, I failed to meet a single family that grieved for fewer than five immediate members.
Now the slaughter that began with the invasion 23 years ago has returned. In the tumultuous aftermath of Suharto's forced resignation last year, the new regime headed by his stooge, BJ Habibie, offered the East Timorese a vote on autonomy within Indonesia or independence. What Habibie failed to spell out was that real power remained with the army that Suharto built as a force for colonial expansion and domestic oppression and which has devoted itself to destroying the prospect of a free vote set by the UN for August 8.
While the army chief, General Wiranto, gives bogus public support to the "peace process", there is abundant evidence that his officers train, arm and pay death squads to murder and intimidate anyone associated with the independence movement. "Just as it seemed the next generation might not be born in tears," wrote a friend from the capital, Dili, "hope is being snatched away from us." And the Blair government, those noted fighters for "humanitarian values" and against "repressive governments" are up to their necks in it.
Britain is the biggest supplier of weapons to the Indonesian military. Everything from surface to air missiles, to anti-riot vehicles and cluster bombs, comes from Britain. In 1997, the joint East Timorese Nobel peace prize winner, Bishop Carlos Belo, came to London to appeal to Tony Blair and Robin Cook. "Please do not sustain any longer a conflict which without these [arms] sales could never have been pursued in the first place, nor for so long," he begged.
Their response was to secretly approve 64 new arms shipments to the Indonesian army, using "commercial confidentiality" to justify ministers' refusal to answer MPs' questions. In March, just as the media's attention was concentrated on Kosovo, the government released, without warning, its long delayed annual report for 1998 on arms sales. Although hiding more than it reveals, the report confirms that Labour approved 92 arms contracts to Indonesia up to last December. These include the weapons prized by the Kopassus special forces, which led the invasion of East Timor and are behind the campaign of terror aimed at destroying the referendum.
On April 29 Robin Cook routinely denounced the iniquities of "the Milosevic war machine", as 16 Hawk fighter-bombers were secretly delivered to the Indonesian military by British Aerospace. Others will soon be on their way. These were originally approved by the Tories. Last January, the late Derek Fatchett, then foreign office minister, told me: "The legal advice that we had was that we had no power to revoke the [Hawks'] licences..." Two months later, the annual report acknowledged the government's power to revoke licences on page 20.
Armed with the same missiles and cluster bombs currently being used to great effect against civilians in Serbia and Kosovo, Hawk aircraft are ideally suited for the mountain passes of East Timor. The foreign office refrain is that the Indonesians would never dare betray their solemn "assurances" and use "our equipment" in their illegal colony. The British taxpayer might object; the Hawks, after all, are virtually gifts under an export credit system designed for tyrants without the readies. Alas, an outspoken member of Labour's opposition front bench gave the game away on May 11 1994, when he told parliament, "Hawk aircraft have been observed on bombing runs in East Timor in most years since 1984." His name is also Robin Cook.
Mark Higson, the former foreign office official commended by the Scott inquiry into the arms-for-Iraq scandal, described "a culture of lying" pervading Britain's foreign policy establishment. "Like so much of the lethal equipment we sold the Indonesians," he told me, "the Hawks were destined for East Timor. Everybody [at the foreign office] knew that."
The Blair government is frightened of public opinion on this issue. The tens of thousands of people who have phoned television companies and written to their MPs over the years should now insist that the government stop, forthwith, the shipment of every bomber and gun and bullet to its monstrous clients, and that the prime minister and his foreign secretary demand that the East Timorese people and their leader, Xanana Gusmao, are set free, and that Suharto joins Milosevic in the dock. If Blair and Cook continue as accessories, history will indict them, too.
AUSTRALIA BECKONS A WAR WITH CHINA Australia is sleep-walking into a confrontation with China. Wars can happen suddenly in an atmosphere of mistrust and provocation, especially if a minor power, like Australia, abandons its independence for an "alliance" with an unstable superpower.
The Peter Hains beware... While his more senior colleagues in Whitehall and Washington understandably fall silent on the mounting deaths in Iraq, the Foreign Office minister Peter Hain has become a strangely aggressive voice in promoting the failed and lethal embargo.
"We dropped a few civilians", said Sgt Eric Schrumpf of the US Marines "We had a great day," said Sgt Eric Schrumpf of the US Marines last Saturday. "We killed a lot of people."


A look at key concept and production vehicles introduced at the 2013 Los Angeles Auto Show this week.
Anders Warming, the head of Mini design, introduced the 2014 Cooper, with an enlarged bulldog nose, larger footprint and enhanced luggage and cargo area. Dipping into parent BMW's technology bin, the third-generation Mini Cooper hardtop will offer an optional heads-up display, camera-based active cruise control, collision and pedestrian warning systems, a rearview camera, LED highlights as well as parking and high-beam assistance features.
It was no accident Chevrolet showcased the all-new, mid-sized Colorado pickup truck at the Los Angeles Auto Show. Chevy, reentering the shrinking segment after a brief hiatus, hopes to poach the mostly young, male consumers that favor the Toyota Tacoma. The so-called lifestyle truck will be aimed at surfers and families that spend a lot of time outdoors, especially in L.A., the biggest single market for mid-sized pickups.
Hyundai's decadelong campaign to engineer a fuel cell vehicle pays off next spring with the launch of the hydrogen-powered Tucson crossover. The Tucson will be available as a lease-only vehicle in southern California for $2,999 down and $499 per month for 36 months -- and that includes fuel, regardless of how much hydrogen the lessee uses. The fuel cell Tucson is a coup for Hyundai as it arrives before similar vehicles from General Motors, Ford, Chrysler Group and other major automakers. The Tucson's fuel cell stack, power electronics and other hydrogen-specific parts were all developed in-house.
Scott Keogh, president of Audi of America, introduced the new Audi A3 sedan, left, and high-performance Audi S3. Audi's revamped and expanded A3 lineup will begin an 18 month-long North American rollout this spring with the sedan. A hybrid, diesel variant, convertible, and the high-performance S3 will follow. The Sportback e-tron hybrid, powered by gasoline and electricity, is due in early 2015.
The F-type has helped boost Jaguar sales.
The Ford Edge crossover is due for its first major makeover and will borrow heavily from this concept that sports styling themes from the latest Fusion, Escape and Explorer. Designed to be sold in more markets worldwide, notably China, Ford hints the mid-sized crossover will be loaded with new gear such as obstacle detection, active grille shutters for better aerodynamics and fuel economy, automatic assisted parking and stop-start technology. It is expected to go on sale in early 2015.
Kia Motors' march up the luxury ladder continues with the K900 rear-wheel drive sedan based on the same platform that spawned the Hyundai Genesis and Equus. Kia's new flagship reaches U.S. showrooms in the first quarter of 2014 with an entry price of around $50,000 for models equipped with a base 3.8-liter, V-6 engine. Well-equipped models powered by the Hyundai Motor Group's 5.0-liter V-8 engine will top out in the mid-$60,000s, Kia executives say. Three years of complimentary maintenance will also be standard on the K900.
Porsche is poised to add a second crossover to its lineup when the compact Macan goes on sale in the spring. U.S. sales of the Macan are projected to total more than 10,000 in 2014 and top 16,000 in 2015, IHS Automotive estimates, resulting in Porsche becoming an SUV company that also engineers and markets revered sports cars. With a broad range of Macan variants planned -- a four-cylinder and diesel option among them -- the German carmaker's annual global sales will be on track to top the 200,000 mark for the first time.Pricing will start at $49,900, plus $995 destination, for the Macan S.
Subaru is readying a longer, roomier and sportier looking WRX sedan to separate the high-performance car from its sibling -- the compact Impreza. The 2015 WRX features a new 268-hp, 2.0-liter direct-injection turbo boxer engine and a six-speed manual transmission. A continuously variable automatic transmission will be optional. It sits on a modified Impreza platform but features an all-new body. It goes on sale March 15 in the United States and will be offered only as a sedan; the five-door hatchback has been dropped.
Honda's successor to the FCX Clarity hydrogen fuel cell vehicle will have a range of 300 miles and its fuel cell stack -- 33 percent smaller than the FCX' stack -- will be housed entirely in the engine compartment. The mid-sized FCEV Concept previews a 2015 production vehicle, which will feature "significant gains in real-world performance, cost reduction, efficiency [and] packaging," Honda said. The five-passenger vehicle, Honda said, will boast a refueling time of about three minutes. The current FCX Clarity has a range of 240 miles.


Kerns are Irish light Infantry made up of freemen armed with small hand weapons. Relying on agility rather than armour these light axemen can provide an unexpected challenge to their more heavily armoured opponents. Many Kerns seek an escape from poverty by fighting as mercenaries.


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Q: Hot to get the value from the form to the php as it was incremented and decremented I wanted to get the incremented and decremented number and print it out to the php.
This is my code:

Quantity:

<button id = "decrement" onclick="decrement()">
         </button>

       <form action="" method ="get">
            <input id="quantity" type="number" name="quant" value="0" min="0">
        </form>

<button id = "increment" onclick="increment()"></button>

        <?php
        $qty = $_GET['quant'];
        echo $qty;
        ?>

Thank you so much in advance!

A: Here's something I put together. It's a very minimal example, but should help you get started. Added comments so it should help you understand how the code is working.
<?php
  // gets the value submitted by the form
  $number = isset($_POST['txtNumber']) ? $_POST['txtNumber'] : 0;
?>

<form action="" method="POST">
  <input type="number" id="txtNumber" name="txtNumber" min="0" value="<?php echo $number; ?>">
  <button id="btnIncrease">+</button>
  <button id="btnDecrease">-</button>
</form>

<?php
  echo 'The number is currently ' . $number;
?>

redpajama_set_name: RedPajamaStackExchange


text:
Fox and Friends First
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Watters' World : FOXNEWSW : November 24, 2018 8:00pm-9:00pm PST
"the new york times," the last spot, the very bottom, the worst president ever in the minds of the experts, drum roll please, is, yes, donald j. trump. >> bottom line is donald trump is dangerous and toxic for this country. he's dangerous and toxic every time he tweets about his nuclear button being bigger -- i mean, come on. this is someone who is not stable, and i've been saying it from the beginning, and i will continue to say it until somebody looks into his mental stability. >> okay, i hear you. >> that is where we are. >> he is a terrorist sympathizer. >> is that guy on twitter? that's a fox news host. that guy railing against the media, that's a fox news host. that's not the president. jesse: there's a difference between negative news, as we saw, and fake news -- we know all the instances of fake news because we watched the president hand out the fake news awards. but with that said, tommy, 92% of this coverage of the president has been negative, yet his approval ratings in the high 40s. what do you account for that? >> well, i mean, the media hates donald trump. we all know
"the new york times," the last spot, the very bottom, the worst president ever in the minds of the experts, drum roll please, is, yes, donald j. trump. >> bottom line is donald trump is dangerous and toxic for this country. he's dangerous and toxic every time he tweets about his nuclear button being bigger -- i mean, come on. this is someone who is not stable, and i've been saying it from the beginning, and i will continue to say it until somebody looks into his mental...
Justice With Judge Jeanine : FOXNEWSW : November 24, 2018 9:00pm-10:00pm PST
janeen making justice number one and liar and leakers and liberals number one on "new york times" bees sellers list we have a great show on deck for you ann coulter michelle, and a steve just to name a few of the great guests joining me live tonight. plus, you won't want to miss my special trip to the museum of the bible, exploring the world of --o fashion, art, and food in the bible. but first my open. ♪ this week, hillary clinton said that europe should no longer offer rough peage and support to migrants say what no more refuge and support for migrant the woman has been out in woods too long. her latest flip-flop from the left generic open border globalist, sanctuary let them all in policy, is a stunning reversal. she even breaks with her pal, barack obama, who said this about the caravan coming to the united states. >> 2018, they're telling you that the the threat to america is a bunch of poor refugees of thousand miles away. >> now, barack, i don't have time to talk to you through this. but you're wrong. thousands of miles away, they're here. in a matter of weeks, from central am
janeen making justice number one and liar and leakers and liberals number one on "new york times" bees sellers list we have a great show on deck for you ann coulter michelle, and a steve just to name a few of the great guests joining me live tonight. plus, you won't want to miss my special trip to the museum of the bible, exploring the world of --o fashion, art, and food in the bible. but first my open. ♪ this week, hillary clinton said that europe should no longer offer rough...
Life, Liberty & Levin : FOXNEWSW : November 18, 2018 7:00pm-8:01pm PST
york news paper prinked printed a fake pt at proclamation, he ordered his generals to arrest the journalists. woodrow wilson set up an intelligence operation again the media, and obama after reporters, trump has not done that. >> he has an affect psychologically on the journalists, he conveys idea he has no respect for him, he has contempt they have violated their journallive -- journalistic ethical. you remember obama went after ap reporters and james rosen at fox, he said in a campaign trail, you should debate sean hannity, i think he said you will tear him up, if trump said, you would tear somebody up, for them, something about trump, his speech, mannerism, appear answer, is not just journalists he is an a4 affront to their -- >> could it be his existent because he fights back and calls them out by name. saying fake news that is the enemy of the people. >> i think so. sources -- we know a lot of cases it did not happen, a person writes a creative story and calls it journalism, then they hide behind a facade, it is like a chain, in weakest link destroys it it they have not doe
york news paper prinked printed a fake pt at proclamation, he ordered his generals to arrest the journalists. woodrow wilson set up an intelligence operation again the media, and obama after reporters, trump has not done that. >> he has an affect psychologically on the journalists, he conveys idea he has no respect for him, he has contempt they have violated their journallive -- journalistic ethical. you remember obama went after ap reporters and james rosen at fox, he said in a campaign...
Tucker Carlson Tonight : FOXNEWSW : November 2, 2018 9:00pm-10:00pm PDT
america than fear of god. there's more fear of "the new york times" editorial page than fear of god. and even you're an atheist, you can acknowledge the truth of that. and when you bust that fear, it's over. they wish that the fear will work. that's why they gather around your table and scream at you, because the previous tactic didn't work, so they keep upping it. but at a given point it won't work and that's the hope, that the american people understand there's a vicious cycle taking place on the part not of liberals but of leftists. in our film, he says, as a liberal, as a democrat, as an american, as a jew, i far more fear the left than the right. >> tucker: so how long does this last? >> i think there's a simple thing we could do. i think we're all guilty of doing it. i watch your show and listen to your show religiously. and you guys do it. and i think it's unconscious. and we all do it, where you go, look, here are my thoughts on immigration. and then you stop and go, hispanics are great people. i work with many hispanic people. i have no ill will. and then you go ahead and t
america than fear of god. there's more fear of "the new york times" editorial page than fear of god. and even you're an atheist, you can acknowledge the truth of that. and when you bust that fear, it's over. they wish that the fear will work. that's why they gather around your table and scream at you, because the previous tactic didn't work, so they keep upping it. but at a given point it won't work and that's the hope, that the american people understand there's a vicious cycle...
Tucker Carlson Tonight : FOXNEWSW : November 1, 2018 5:00pm-6:00pm PDT
writes for "the new york times" on the other at princeton which is an ivy league college in new jersey. both have impressive credentials and both are considered deep thinkers by most of the other people in this country who think of themselves as intellectuals. watch as they explained what they have learned since the 2016 election. >> what i did wrong in 2016 as i overestimated white people. i didn't think white people would put him in office. >> i'm not willing to let white voters off the hook. i think there are a large number, i would say the majority of white americans in this country who are not just democrats but people of conscience, who are good americans. i believe that they need to move from saying, well, i don't like his tweets but the economy is doing okay. they need to move from there to reality which is that we have a white nationalist president with a threat to american democracy. >> tucker: now there was a time not so long ago when language like this was considered textbook race hatred even by liberal democrats. you weren't allowed to blame entire races of people for anyt
writes for "the new york times" on the other at princeton which is an ivy league college in new jersey. both have impressive credentials and both are considered deep thinkers by most of the other people in this country who think of themselves as intellectuals. watch as they explained what they have learned since the 2016 election. >> what i did wrong in 2016 as i overestimated white people. i didn't think white people would put him in office. >> i'm not willing to let...
gillibrand from new york was a buddy buddy with the guy who wants to remove the border between the united states in mexico. so there is -- not just an activist community, but within the left of this nation, my own party, i hate to say -- who want open borders. that feeds into this issue, not only did and how do we take care of them, but ultimately, where they to vote for? there is a play there that i think one could argue, this is a political play, this is about boats. i think it is there to have the concern and that fear. >> tucker: if i hear one more on cable news cry racism when somebody tries to have and honest conversation, i'm getting rid of my television. thank you very much. great to see you. the florida recount continues tonight. democrats are battling to change the results by any means necessary. that will not surprise you. of the details might, though. we will have them after the break. ♪ when heartburn hits... fight back fast with tums smoothies. it starts dissolving the instant it touches your tongue... and neutralizes stomach acid at the source. ♪ tum tum tum tum.
gillibrand from new york was a buddy buddy with the guy who wants to remove the border between the united states in mexico. so there is -- not just an activist community, but within the left of this nation, my own party, i hate to say -- who want open borders. that feeds into this issue, not only did and how do we take care of them, but ultimately, where they to vote for? there is a play there that i think one could argue, this is a political play, this is about boats. i think it is there to...
Fox and Friends First : FOXNEWSW : November 14, 2018 1:00am-2:00am PST
, waking up on "fox and friends first" on wednesday morning, actually one in new york city and they say we may get snow tomorrow. i think texas already did. thank you for starting your day with us. let's begin in florida where that ballot drama is heating up. voting machines in palm beach county overheating forcing the restart of 175,000 early votes. a judge giving them an extra 5 days to tally the ballots. griff jenkins at the broward county office of elections where they say they will meet tomorrow's recount deadline. do you think they will make it? >> reporter: i think they will make it and let me tell you, broward county elections staff is and giving up. they are still at it. let me show you the scene. they counted 199,70015,000 total ballots, separating some mail ins, a little complicated but they believe they will get it done yesterday. the supervisor doctor brenda snipes said as much when she took to the mike's. listen. >> we won't miss the deadline. we won't miss it. all the emphasis, all the focus is on me but i have a great staff that takes on any task and their job is to get
, waking up on "fox and friends first" on wednesday morning, actually one in new york city and they say we may get snow tomorrow. i think texas already did. thank you for starting your day with us. let's begin in florida where that ballot drama is heating up. voting machines in palm beach county overheating forcing the restart of 175,000 early votes. a judge giving them an extra 5 days to tally the ballots. griff jenkins at the broward county office of elections where they say they...
Tucker Carlson Tonight : FOXNEWSW : November 14, 2018 9:00pm-10:00pm PST
gillibrand from new york was a buddy buddy with the guy who wants to remove the border between the united states in mexico. there is an element within this country, not just an activist community but within the left of this nation, my own party, i hate to say, who want open borders. that of course then feeds into this issue, not only how do we take care of them, but ultimately, who are they going to vote for? there is a play there that i think one could argue, this is a political play, this is abouty votes. i think it is there to have the concern and that fear. >> tucker: if i hear one more moron on cable news cry racism when somebody tries to have an honest conversation, i'm getting rid of my television. i mean that. ing can't handle it. bryan dean wright, thank you very much.uc great to see you. the florida recount continues tonight. democrats are battling to change the results by any meansec necessary. that will not surprise you. the details might, though. we will have them after the break. ♪ . we just upload our logo, and if we have any questions, customer service is there to
gillibrand from new york was a buddy buddy with the guy who wants to remove the border between the united states in mexico. there is an element within this country, not just an activist community but within the left of this nation, my own party, i hate to say, who want open borders. that of course then feeds into this issue, not only how do we take care of them, but ultimately, who are they going to vote for? there is a play there that i think one could argue, this is a political play, this is...
new york city. jillian: will show go on? we are live in manhattan. rob: would you eat turkey flavored ice cream? jillian: no. this is turning heads this morning, "fox and friends first" starts right now. ♪ ♪ thank you for being a friend ♪ travel down the road and back again ♪ your heart is true ♪ jillian: todd likes this song. rob: your golden girls music selection. jillian: the macy's thanksgiving day parade is set to kick off, happy thanksgiving, you are watching "fox and friends first" on thursday morning. heather: thank you for starting the day with us. are you having turkey trouble? carley: we will answer your questions. todd: she is an official person. send us an email if you can post on all our social media pages, we can get you the answers you need in time. carley: a fox news alert, new plan could force migrant caravan members to stay in mexico until there asylum cases are processed. rob: the president fires back at those trying to halt his agenda. >> reporter: the new plan is called remain in mexico. asylum-seekers will now have to prove a reasonable fear o
new york city. jillian: will show go on? we are live in manhattan. rob: would you eat turkey flavored ice cream? jillian: no. this is turning heads this morning, "fox and friends first" starts right now. ♪ ♪ thank you for being a friend ♪ travel down the road and back again ♪ your heart is true ♪ jillian: todd likes this song. rob: your golden girls music selection. jillian: the macy's thanksgiving day parade is set to kick off, happy thanksgiving, you are watching...
The Greg Gutfeld Show : FOXNEWSW : November 3, 2018 7:00pm-8:00pm PDT
specifically. kat: yeah, me and john stossel. larry sharp fort new york. exactly one will from the crowd just now. larry sharp. you know, i will vote but i don't know what will happen. i know mike i will not win which is makes elections not stressful for me ultimately. greg: it's true. i live in new york and i know anyone i bought for will not w win. kat: i don't leave the house often and i will leave the house to vote but i don't know why but i will. i think it will come down to enthusiasm. democrats are enthusiastic and paul so they're more enthusiastic a public and voters so republican voters need to get more enthusiastic. i know it's boring. i know you have to wait in line. there's not even a roller coaster at the end of it. and you have to leave your apartment and you don't get to buy or drink anything which is the only reason i leave my apartment and only sometimes. greg: usually you have it delivered. kat: i've used post made four times a day. greg: you are a sad person. last word to you, tyrus. tyrus: thanks. look, historically when president comes then the other side get t
specifically. kat: yeah, me and john stossel. larry sharp fort new york. exactly one will from the crowd just now. larry sharp. you know, i will vote but i don't know what will happen. i know mike i will not win which is makes elections not stressful for me ultimately. greg: it's true. i live in new york and i know anyone i bought for will not w win. kat: i don't leave the house often and i will leave the house to vote but i don't know why but i will. i think it will come down to enthusiasm....
new york, and virginia pays more but why would they need to pay that much in taxpayer dollars to the richest man in the world for the privilege of having the company moved to new york? >> i came on because the state representative there, cortez, made a statement and made comments basically saying that she didn't want to take amazon's jobs in new york because perhaps it wasn't going to be unionized double, et cetera. and you agreed with cortez in this situation. >> tucker: no, i wasn't -- i'm sitting right here and i can tell you what i agreed with. i'm never ashamed of that. i thought it was a fair point. why is new york which is crumbling, and i may be there tonight, but the city is falling apart, that smells on the subway brakes. why would they be sending money to the richest man in the world? why wouldn't it be used to fix the subway? i'm confused. >> i typically, rarely if ever agree with the socialist and certainly don't in this situation, on many levels. i think what happened here and we can all recall that amazon had an open bed across the country in which all these states cou
new york, and virginia pays more but why would they need to pay that much in taxpayer dollars to the richest man in the world for the privilege of having the company moved to new york? >> i came on because the state representative there, cortez, made a statement and made comments basically saying that she didn't want to take amazon's jobs in new york because perhaps it wasn't going to be unionized double, et cetera. and you agreed with cortez in this situation. >> tucker: no, i...
. "fox and friends first" starts right now. a rainy start to the day in new york city. we expect some snow flurries. we talk to janice dean later in the second hour of "fox and friends first". thank you for starting your day with us. let's start with the opposite of what is going on here, fox news alert, one of several wildfires terry to california is the deadliest in state history and new fires are threatening more communities. claudia cowan has a look at the hardest hit areas in paradise, california. >> reporter: the most distractive wildfire in california history on track to be the state's deadliest. apocalyptic scenes like this from the camp fire is grews search the smoking ruins in paradise, california, finding more bodies with 200 still reported missing. >> we had an engine crew discover a body. >> two friends are missing. what out of gary and one up paradise. i hope it is not one of the body counts. >> reporter: from the ground and the air, 8000 firefighters battling 3 large fires in northern and southern california. and an area larger than the city of san diego. this will dest
. "fox and friends first" starts right now. a rainy start to the day in new york city. we expect some snow flurries. we talk to janice dean later in the second hour of "fox and friends first". thank you for starting your day with us. let's start with the opposite of what is going on here, fox news alert, one of several wildfires terry to california is the deadliest in state history and new fires are threatening more communities. claudia cowan has a look at the hardest hit...
FOX & Friends : FOXNEWSW : November 22, 2018 3:00am-6:00am PST
. >> millions of people lining the streets of new york city for the macy's thanksgiving day parade. >> e. as the nypd steps up security. >> nypd says some of its dogs can now pick up the scent of explosives from hundreds of feet away. >> speak with american heroes sacrificing their thanksgiving with their families, planning on shipping 300,000 pounds of turkey around the world. who says you can't go home ♪ who says you can't go back ♪ all around the world ♪ as a as a matter of fact. ♪ only one place that i want to go. rachel: you are here, happy thanksgiving, everybody. ed: griff is in the studio. griff: i have new york city hair which has become a thing. maybe my favorite thing in the entire world along with the thanksgiving ed henry ensemble. it was ed henry that taught me to wear a pocket square. we have a thanksgiving time pocket square. i feel like a million bucks. rachel: they taught us when we were at the store spent a significant amount of time how to match the tie. it can't be too matchy matchy. look at this. that's what they told us. and, you know, they taught us roughi
. >> millions of people lining the streets of new york city for the macy's thanksgiving day parade. >> e. as the nypd steps up security. >> nypd says some of its dogs can now pick up the scent of explosives from hundreds of feet away. >> speak with american heroes sacrificing their thanksgiving with their families, planning on shipping 300,000 pounds of turkey around the world. who says you can't go home ♪ who says you can't go back ♪ all around the world ♪ as a as...
. rachel: there is my kids and i we were all in new york city because i'm working and we went to a diner. we didn't talk politics because there is not enough room for us at one table. my son said i know there is a turkey dinner on the menu but can i have a burger? i'm like sure you are in a new york city diner. we were in two booths and i was taking care of my little ones who dropped a pie on the floor and stepped on it. steve: dropped a pie. >> not a lot of politics just handling kids. griff: go back to another shot. this is the jenkins clan trying to brave the coldest possible day in the history of of the country on macy day parade. we braved it. we went in and had a great thanksgiving dinner nearby. there is my girls right there. steve: that's frisco's i see the fox news. how much are they paying you? it was cold out there. this a great shot though. this is the forced smile like hurry up, take the photo and feed me. steve: that's great. let us know how you spent your thanksgiving. send us pictures "fox & picture friends@foxnews.com. steve: we know how the president celebrated yesterda
. rachel: there is my kids and i we were all in new york city because i'm working and we went to a diner. we didn't talk politics because there is not enough room for us at one table. my son said i know there is a turkey dinner on the menu but can i have a burger? i'm like sure you are in a new york city diner. we were in two booths and i was taking care of my little ones who dropped a pie on the floor and stepped on it. steve: dropped a pie. >> not a lot of politics just handling kids....
The Journal Editorial Report : FOXNEWSW : November 18, 2018 12:00pm-1:00pm PST
debate in 2020. paul: thanks, kate, amazon's announcements of headquarters in new york and virginia drawing backlash as taxpayers and local officials find out how much they are paying for the deal. alright, i brought in ensure max protein... ...to give you the protein you need with less of the sugar you don't. [grunting noise] i'll take that. 30 grams of protein and 1 gram of sugar. ensure max protein. in two great flavors. that skills like teamwork, attention to detail, and customer service are critical to business success. like the ones we teach here, every day. andshould happen everydred five hundred years, right?cess. fact is, there have been twenty-six in the last decade. allstate is adapting. with drones to assess home damage sooner. and if a flying object damages your car, you can snap a photo and get your claim processed in hours, not days. plus, allstate can pay your claim in minutes. now that you know the truth... are you in good hands? paul: in a much anticipated announcement amazon said this week that it plans to open two new headquarters in the dc suburbs of arlington,
debate in 2020. paul: thanks, kate, amazon's announcements of headquarters in new york and virginia drawing backlash as taxpayers and local officials find out how much they are paying for the deal. alright, i brought in ensure max protein... ...to give you the protein you need with less of the sugar you don't. [grunting noise] i'll take that. 30 grams of protein and 1 gram of sugar. ensure max protein. in two great flavors. that skills like teamwork, attention to detail, and customer service...
MediaBuzz : FOXNEWSW : November 19, 2018 12:00am-1:00am PST
facebook by the "new york times." today is the day you're going to get motivated... get stronger... get closer. start listening today to the world's largest selection of audiobooks on audible. and now, get more. for just $14.95 a month, you'll get a credit a month good for any audiobook, plus two audible originals exclusive titles you can't find anywhere else. if you don't like a book, you can exchange it any time, no questions asked. automatically roll your credits over to the next month if you don't use them. with the free audible app, you can listen anytime, and anywhere. plus for the first time ever, you'll get access to exclusive fitness programs a $95 value free with membership. start a 30-day trial today and your first audiobook is free. cancel anytime and your books are yours to keep forever. audible. the most inspiring minds. the most compelling stories. text "listen16" to 500500 to start your free trial today. howie: facebook has been telling us for a long time that it's going to do better. mark zuckerberg and his deputy sheryl sandberg spent years minimizing it's problems the
facebook by the "new york times." today is the day you're going to get motivated... get stronger... get closer. start listening today to the world's largest selection of audiobooks on audible. and now, get more. for just $14.95 a month, you'll get a credit a month good for any audiobook, plus two audible originals exclusive titles you can't find anywhere else. if you don't like a book, you can exchange it any time, no questions asked. automatically roll your credits over to the next...
: the purple on that. >> we have cold air coming in from canada. not as cold as yesterday in new york but it is setting the stage for another winter storm that will affect the central us over the next couple days. the past 24 hours a quick clipper system moving across the midwest and great lakes moving eastward and the next big system will originate from the west. that is where we will see light snow activity across the midwest and great lakes but then we are dealing with several systems moving into the west. they need the rain fall. it will be a lot of rain so flash flooding will be a concern and a lot of snowpack in nevada, several feet of snow and we could see potential for several inches of rain along the coast but that is the storm system that will move into the central us bringing a mix of snow, freezing rain, sleet and severe weather and that will move eastward on saturday to the east coast, too warm for snow on the east coast but we will see snow across the northern plains and the midwest. we will keep you up to date. over to you. rob: fox news getting an exclusive look at potenti
: the purple on that. >> we have cold air coming in from canada. not as cold as yesterday in new york but it is setting the stage for another winter storm that will affect the central us over the next couple days. the past 24 hours a quick clipper system moving across the midwest and great lakes moving eastward and the next big system will originate from the west. that is where we will see light snow activity across the midwest and great lakes but then we are dealing with several systems...
The Ingraham Angle : FOXNEWSW : November 5, 2018 11:00pm-12:00am PST
has happened -- two years ago -- every day every newspaper. "new york times," washington post. anonymous intelligence sources confirming that trump collidedat with oudin. -- putin. nothing happened. it was made up. w hillary clinton collided with russia. hillary clintonia rigged the election. [ cheering ] >> they got the message. these rallies i have to tell you they are the envy of official washington. there isn't a single elected official in either party who can do what this is tonight. [ cheering ] >> other than donald trump. no one. and they are jealous. this is not supposed to h. you people are supposed to love them not trump. so guess what? they want to get in on it. bill and hillary clinton and their national stadium tour. talking about and have you seen obama. he has been stumping down in florida. he is drawing crowds of 2,000 people. joe biden can't fill a phone booth because he is looking for something to punch out. this is incredible. and you know -- a little history when i first started watching the campaign, i watched the president and his family come down the esc
has happened -- two years ago -- every day every newspaper. "new york times," washington post. anonymous intelligence sources confirming that trump collidedat with oudin. -- putin. nothing happened. it was made up. w hillary clinton collided with russia. hillary clintonia rigged the election. [ cheering ] >> they got the message. these rallies i have to tell you they are the envy of official washington. there isn't a single elected official in either party who can do what this...
MediaBuzz : FOXNEWSW : November 18, 2018 8:00am-9:00am PST
. an investigation of facebook by the "new york times." there's little rest for a single dad, and back pain made it hard to sleep and get up on time. then i found aleve pm. the only one to combine a safe sleep aid, plus the 12 hour pain relieving strength of aleve. i'm back. aleve pm for a better am. if you're waiting patiently for a liver transplant, it could cost you your life. it's time to get out of line with upmc. at upmc, living-donor transplants put you first. so you don't die waiting. upmc does more living-donor liver transplants than any other center in the nation. find out more and get out of line today. howie: facebook has been telling us for a long time that it's going to do better. mark zuckerberg and his deputy sheryl sandberg spent years minimizing it's problems then tomorrow reluctantly promised to do better. >> personally i think the idea the fake news on facebook which it's a very small amount of the content, influenced the election in any way i think is a pretty crazy idea. >> we didn't take a broad enough view of our responsibility and that was a big mistake and it
. an investigation of facebook by the "new york times." there's little rest for a single dad, and back pain made it hard to sleep and get up on time. then i found aleve pm. the only one to combine a safe sleep aid, plus the 12 hour pain relieving strength of aleve. i'm back. aleve pm for a better am. if you're waiting patiently for a liver transplant, it could cost you your life. it's time to get out of line with upmc. at upmc, living-donor transplants put you first. so you don't die...
announcements of headquarters in new york and virginia drawing backlash as taxpayers and local officials find out how much they are paying for the deal. doug, doug! douglas! we're running dangerously low on beans. people love your beans, doug. they love 'em. doooooooooug! you want to go sell some tacos? progressive knows small business makes big demands. doug, where do we get a replacement chili pepper bulb? so we'll design the insurance solution that fits your business. it's a very niche bulb. it's a specialty bulb. vojimmy (shouting): james!as been jimmy's longest. he's survived record rain and a supplier that went belly up. so while he's proud to have helped put a roof over the heads of hundreds of families, he's most proud of the one he's kept over his own. brand vo: get the most out of your money, whether you're using quickbooks smart invoicing to get paid twice as fast or automatically tracking your mileage. smarter business tools for the world's hardest workers. quickbooks. backing you. paul: in a much anticipated announcement amazon said this week that it plans to open two new headqua
announcements of headquarters in new york and virginia drawing backlash as taxpayers and local officials find out how much they are paying for the deal. doug, doug! douglas! we're running dangerously low on beans. people love your beans, doug. they love 'em. doooooooooug! you want to go sell some tacos? progressive knows small business makes big demands. doug, where do we get a replacement chili pepper bulb? so we'll design the insurance solution that fits your business. it's a very niche...
Shepard Smith Reporting : FOXNEWSW : November 29, 2018 12:00pm-1:01pm PST
dana perino. here's shep. >> shepard: it's noon on the west coast, 3:00 in new york where president trump's former personal lawyer and fixer has pleaded guilty again. michael cohen admits he lied to congress about plans saying he was trying to stick to the candidate's political message. the president calls him a liar and weak. the president calling off his meeting with vladimir putin. and stormy daniels said she never wanted to sue president trump but her lawyer did it anyway. reporting begins now. our reporting begins with president trump's normer attorney and fixer michael cohen admitting he lied to congress about contacts he had with the kremlin, about building a trump tower in moscow and he misled the lawmakers about how much president trump was involved. michael cohen pleaded guilty this morning federal court in manhattan. the plea was part of a deal with the special counsel robert mueller in exchange for cohen's cooperation in the russian investigation. according to new records, cohen now admits that he was in talks with the russia president vladimir putin's right-hand man and
dana perino. here's shep. >> shepard: it's noon on the west coast, 3:00 in new york where president trump's former personal lawyer and fixer has pleaded guilty again. michael cohen admits he lied to congress about plans saying he was trying to stick to the candidate's political message. the president calls him a liar and weak. the president calling off his meeting with vladimir putin. and stormy daniels said she never wanted to sue president trump but her lawyer did it anyway. reporting...
middleman and letting chuck schumer speak directly for him. new york senators steal this from the people of florida. a final moment today, senator nelson and governor scott are both going to allegedly appear for the senate class photo. governor scott is in dc for orientation. if both show up for the same class photo for the new senate class it will be an interesting time. jillian: that will be interesting. rob: i look forward to that. jillian: key leaders up for grabs on capitol hill, all eyes on the house republican leadership race. kevin mccarthy is favored to stay on as minority leader despite a challenge from jim jordan. the house speaker vote won't come until later this month. nancy pelosi fighting to hold off a rebellion from incoming lawmakers hoping for a fresh face and commitment to end bipartisan gridlock. the 78-year-old pelosi was speaker of the house from 2007 into 2011. the senate votes today, major changes are not expected. incoming democratic lawmakers could pose a major roadblock for house leadership urging the party to take a hard left. california are in c committeewoma
middleman and letting chuck schumer speak directly for him. new york senators steal this from the people of florida. a final moment today, senator nelson and governor scott are both going to allegedly appear for the senate class photo. governor scott is in dc for orientation. if both show up for the same class photo for the new senate class it will be an interesting time. jillian: that will be interesting. rob: i look forward to that. jillian: key leaders up for grabs on capitol hill, all eyes...
not confirmed or denied the charges exist at a report by the new york times reveals paul manafort has been giving donald trump's legal team on the road mueller russia probe. jillian: the most famous christmas tree in the world getting lit tonight. the rockefeller center tree in new york city is a 72 foot norway spruce topped with a 9 foot star made of 3 million crystals. in dc the president and first lady will take part in the 96th annual christmas tree lighting ceremony near the white house. always gets you in the festive mood if you are not already. rob: pretty fair weather for this. >> we may get some snowflakes in new york city this morning when i am outside doing the weather. it is cold outside right now, windchill, feels even colder than that. it is feeling like wintertime across the eastern third of the country. the past 24 hours, see those snowflakes across portions of the great lakes and the northeast, we could get in on that action later this morning and a big snowstorm, snowflakes are in the air. looking across the west, our next system, several systems moving to the west c
not confirmed or denied the charges exist at a report by the new york times reveals paul manafort has been giving donald trump's legal team on the road mueller russia probe. jillian: the most famous christmas tree in the world getting lit tonight. the rockefeller center tree in new york city is a 72 foot norway spruce topped with a 9 foot star made of 3 million crystals. in dc the president and first lady will take part in the 96th annual christmas tree lighting ceremony near the white house....
florida much warmer than we had in new york city. millions brave in the coldest macy's thanksgiving day parade ever. rob: the temperature reached 21 ° during that parade. adam class joins us, it was 21 and windy which makes it feel worse and it will continue. >> reporter: 21, wednesday. as far as thursday thanksgiving forecast it did get to 28 ° at 7:00 pm last night which knocked it out of the top 3 so it turned out not to be like the recordbreaker. it was really cold and is still really cold this morning as we talk about once again temperatures when the colors match my suit that is when you know it is getting cold. 80 ° in new york city, 4 , feels like temperatures in boston, a little farther in land and get into the negatives. it is rigid out there. the middle of the country not as bad. it will continue to be for black friday, temperatures running up to 50 ° in kansas city, closer to freezing in chicago. the story besides the cold temperatures continues to be on the western side of the country. it is so dry throughout california, too much rain and precipitation. some of this
florida much warmer than we had in new york city. millions brave in the coldest macy's thanksgiving day parade ever. rob: the temperature reached 21 ° during that parade. adam class joins us, it was 21 and windy which makes it feel worse and it will continue. >> reporter: 21, wednesday. as far as thursday thanksgiving forecast it did get to 28 ° at 7:00 pm last night which knocked it out of the top 3 so it turned out not to be like the recordbreaker. it was really cold and is still...
The Story With Martha MacCallum : FOXNEWSW : November 2, 2018 4:00pm-5:00pm PDT
cuban-americans there and a lot of folks who fled new york and new jersey for the sunshine state so it's a very interesting mix of florida voters. and it's making for quite a race between maria salazar and donna show layla. that's coming up next. ♪ ♪ ♪ a peaceful night sleep without only imagine... frequent heartburn waking him up. now that dream is a reality. nexium 24hr stops acid before it starts for all-day, all-night protection. can you imagine 24 hours without heartburn? billions of problems. dry mouth? parched mouth? cotton mouth? there's a therabreath for you. therabreath oral rinse and lozenges. help relieve dry mouth using natural enzymes to soothe and moisturize. so you can... breathe easy, there's therabreath at walmart. i am a techie dad.n. i believe the best technology should feel effortless. like magic. at comcast, it's my job to develop, apps and tools that simplify your experience. my name is mike, i'm in product development at comcast. we're working to make things simple, easy and awesome. ♪ >> president trump: hundreds of thousands of children born to ille
cuban-americans there and a lot of folks who fled new york and new jersey for the sunshine state so it's a very interesting mix of florida voters. and it's making for quite a race between maria salazar and donna show layla. that's coming up next. ♪ ♪ ♪ a peaceful night sleep without only imagine... frequent heartburn waking him up. now that dream is a reality. nexium 24hr stops acid before it starts for all-day, all-night protection. can you imagine 24 hours without heartburn? billions...
Special Report With Bret Baier : FOXNEWSW : November 29, 2018 3:00pm-4:00pm PST
as many of us were caught off guard when michael cohen pled guilty in a new york court room to lying to congress about a trump real estate project in russia. the president lambasted him today before leaving for argentina calling him weak and he's lying. while the president has been traveling, reaction to cohen's surprise plea agreement has been growing. there's a lot of talk about what cohen's agreement to work with a special counsel could now mean for the president and his famil family. catherine herridge is here with a closer look at the plea deal and the legal implications but we begin with chief white house correspondent john roberts who is in buenos aires tonight ahead of the president's arrival to the g20 summit. >> i have rarely been to one of the international summits with the news of the summit has not been overshadowed by some unrelated bombshell. it has happened with past presidents and it has happened with almost every international trip president trump has been on. argentina is no different. >> heading to the helicopter this morning on a ten hour flight, president trump
as many of us were caught off guard when michael cohen pled guilty in a new york court room to lying to congress about a trump real estate project in russia. the president lambasted him today before leaving for argentina calling him weak and he's lying. while the president has been traveling, reaction to cohen's surprise plea agreement has been growing. there's a lot of talk about what cohen's agreement to work with a special counsel could now mean for the president and his famil family....
The Next Revolution With Steve Hilton : FOXNEWSW : November 4, 2018 9:00pm-10:00pm PST
good night from new york. we are live from new york with a fired up crowd. are you ready? [applause] they are not making it up. they really are fired up. this election is so important we have so many fantastic guests. we barely know what to do with them all. good evening all. welcome to the next revolution. i'm steve hilton. this is the home of positive populism. positive populism is all about you the american people and how to make your life better. we will debate what's at stake in this election. the economy, jobs and your income. immigration and control america's borders. a new congress that backs the trump agenda or one that blocks it. will we see another victory for the forgotten men and women or will it be the revenge of the elites. so, let's get on with it. our audience will be taking part throughout the show. if you want to take part please follow us. we have guests after every break. you cannot miss a minute of tonight special show. first up, two of your favorite next revolution fox news contributor lisa booth. [applause] where is lisa. former bernie sanders. [inaudible] an
good night from new york. we are live from new york with a fired up crowd. are you ready? [applause] they are not making it up. they really are fired up. this election is so important we have so many fantastic guests. we barely know what to do with them all. good evening all. welcome to the next revolution. i'm steve hilton. this is the home of positive populism. positive populism is all about you the american people and how to make your life better. we will debate what's at stake in this...
prosecute hillary clinton and former fbi director james comey last spring. according to the new york times former white house counsel warned the president he had no authority to issue the order, even suggesting it could get him impeached. the report coming to light as house republicans prepared to hear testimony about the doj investigation into alleged wrongdoing by the clinton foundation scheduled for december 5th. >> donald trump officially answering robert mueller's questions about russian election meddling, a major milestone in special counsel investigation that could soon reach its end. jillian: more on where the investigation goes from here. >> reporter: it is up to robert mueller and as they say in washington those that know aren't talking about his intentions. that possibly word team mueller could go from here. and disclose the report to congress, answers with other respondents. and this kind of combination thereof. despite the white house's frustration this probe will continue until it reachedes a national end putting the brakes on it. the president remains unchanging on this. >>
prosecute hillary clinton and former fbi director james comey last spring. according to the new york times former white house counsel warned the president he had no authority to issue the order, even suggesting it could get him impeached. the report coming to light as house republicans prepared to hear testimony about the doj investigation into alleged wrongdoing by the clinton foundation scheduled for december 5th. >> donald trump officially answering robert mueller's questions about...
Hannity : FOXNEWSW : November 21, 2018 6:00pm-7:00pm PST
"new york times" reported that back in the spring president trump told white house counsel he wanted the justice department to prosecute james comey and hillary clinton. even though the d.a.g. did not file charges, democrats and the media wasted no time making this out to be a major story. take a look. >> this is what happens in a authoritarian countries, the president orders, the president, the leader, orders the investigation and prosecution of his political enemies. >> it's prime a fash evidence of abuse of power. >> this is a scandal, 15 on a 1 to 10 level. >> this is absolutely off the dharts. -- off the charts. donald trump is running his office like the head of a banana republic. >> if i had to channel richard nixon, i think he'd tell this president he's going too far. this is the sort of stuff, banana republic, this is what an autocrat does. >> i read the articles of impeachment against richard nixon. you should read article 2, how similar to what trump has done here. >> so what did president trump do here? last time i checked, comey and clinton aren't being prosecuted. this
"new york times" reported that back in the spring president trump told white house counsel he wanted the justice department to prosecute james comey and hillary clinton. even though the d.a.g. did not file charges, democrats and the media wasted no time making this out to be a major story. take a look. >> this is what happens in a authoritarian countries, the president orders, the president, the leader, orders the investigation and prosecution of his political enemies. >>...
public. jillian: matt whitaker spending the day in new york city, this morning he will speak to the joint terrorism task force and discuss national security efforts. after that, email distribution center at jfk national airport and remark on ways to combat the nation's deadly opioid crisis. rob: forecasted rain for today will help end the camp fire in northern california but the rain also means a big risk of flooding and mudslides, the weather shift coming, 82 people now confirmed dead, 700 unaccounted for, new video shows brave pilots risking their lives to the south in the rules the fire using helicopters rescue 3 people and their dogs trapped in smoke. interior demonstrator ryan think you blames environmental groups by stopping forest management from doing the jobs properly, saying they would rather burn down the entire forest then cut a single tree. jillian: thanksgiving travel off to a good start with few light delays and cancellations, 20,000 commercial flights in the us every day, 4000 flights have been delayed in just 200 flights canceled since tuesday. rob: if you are heade
public. jillian: matt whitaker spending the day in new york city, this morning he will speak to the joint terrorism task force and discuss national security efforts. after that, email distribution center at jfk national airport and remark on ways to combat the nation's deadly opioid crisis. rob: forecasted rain for today will help end the camp fire in northern california but the rain also means a big risk of flooding and mudslides, the weather shift coming, 82 people now confirmed dead, 700...
The Next Revolution With Steve Hilton : FOXNEWSW : November 18, 2018 6:00pm-7:00pm PST
that anonymous "new york times" op-ed i remember everybody's reaction was he is doing the people's work but they aren't because the people elected president trump to be the president's policies move forward and he runs the white house on a day-to-day basis so i found that op-ed to be offensive but there are people surrounding the president or in leadership positions that don't share the viewpoints. >> when you try to get yourself elected to the people of michigan this is what i offer if i have to get steve hilton elected in michigan you may not agree with me maybe you are a democrat so when people say he lost five seats in texas but the president went to bat for you but they are still voting for the candidate as a person i think it's more instinct. people say he was a democrat that he is doing things that he believes in others are going by doctrine. he said i believe this so come aboard and follow me if you cannot let me know others say i will follow you and they said will do you want me to do they say i don't get this guy. i will study the ship a lot of competent people that did n
that anonymous "new york times" op-ed i remember everybody's reaction was he is doing the people's work but they aren't because the people elected president trump to be the president's policies move forward and he runs the white house on a day-to-day basis so i found that op-ed to be offensive but there are people surrounding the president or in leadership positions that don't share the viewpoints. >> when you try to get yourself elected to the people of michigan this is what i...
Hannity : FOXNEWSW : November 28, 2018 10:00pm-11:00pm PST
surrounding the stolen podesta e-mails. just like the d.n.c. ones. many included the "new york times." they actually provided direct links to the leaked e-mails inside of their articles. they did what wikileaks did. similar situation, let's take you back. "hannity" history lesson. 1971 is the year. "new york times" published a top secretk federal report of the vietnam war, it's called "the pentagon papers." the report was stolen. given to "times" by federal employees. other news outlets subsequently published the papers. the supreme court upheld the media's right to publish the stolen "pentagon papers" in aa 1971me ruling 6-3 majority ruling. oh, well, they didn't steal or conspire to steal it. okay. it wasn't ruled wrong by the supreme court. there is the precedent. roger stone or the "new york times" or anyone else wanted to find out if there were smoking gun podesta e-mails in 2015, that says it is not a crime unless they steal it. they hack or they conspire to steal 2 it. nobody has even suggested that happened. this is important. with that said, according to leaked information s
surrounding the stolen podesta e-mails. just like the d.n.c. ones. many included the "new york times." they actually provided direct links to the leaked e-mails inside of their articles. they did what wikileaks did. similar situation, let's take you back. "hannity" history lesson. 1971 is the year. "new york times" published a top secretk federal report of the vietnam war, it's called "the pentagon papers." the report was stolen. given to...
Fox and Friends First : FOXNEWSW : November 9, 2018 2:00am-3:00am PST
ocasio-cortez running into new challenges because her salary hasn't kicked in yet, the new york democrat telling the new york times, quote, i have 3 months without a salary before i'm a member of congress, how do i get an apartment? ocasio-cortez bashing the system in a tweet claiming the country's of electoral system is not designed for working-class people. rob: standing in line for black friday. walmart is throwing a pre-thanksgiving party. jillian: tracy carrasco is here with what you need to know. >> reporter: black friday exactly two weeks away but the deals are starting early. walmart has a appreciably day on thanksgiving, starting at 4:00 pm until 6:00 pm they will be offering free cookies and coffee for shoppers and those sales start at 6:00 pm, you can start shopping on thanksgiving, forget spending time with your family, i guess. they have also got their online deals, black friday online deal starting earlier than ever on wednesday night at 10:00 pm, first time that has ever been done. lots of chances to shop if you're looking to take advantage of those sales. rob: the retaile
ocasio-cortez running into new challenges because her salary hasn't kicked in yet, the new york democrat telling the new york times, quote, i have 3 months without a salary before i'm a member of congress, how do i get an apartment? ocasio-cortez bashing the system in a tweet claiming the country's of electoral system is not designed for working-class people. rob: standing in line for black friday. walmart is throwing a pre-thanksgiving party. jillian: tracy carrasco is here with what you need...
America's News HQ : FOXNEWSW : November 3, 2018 1:00pm-3:00pm PDT
from our new york city newsroom. jacqui. reporter: the tree of life synagogue is closed, still a crime scene after that shooting claimed 11 lives one week ago shabat services drawn congregations. a vigil for victims at tree of life, beginning with a somber moment of silence followed by song and prayer. they were gathered for an area, on the street, cordoned off by police and cones. shabat was held at the nearby temple. 97-year-old rose malinger was buried on friday. her 61-year-old daughter was shot in the attack but survived. worshipers across the country leaning on each other for support. >> it's sad. it is, it shouldn't be not shocking but somehow these things don't seem to stop. >> every faith was here. everyone came together. everyone said, we don't want hate. we want love. we want peace. reporter: a memorial outside the synagogue grew this week, drawing local leaders, mourners and president trump and the first lady who also paid their respects by placing stones on star of david markers. at least four victims remain in the hospital. upmc said on friday the two most seriously
from our new york city newsroom. jacqui. reporter: the tree of life synagogue is closed, still a crime scene after that shooting claimed 11 lives one week ago shabat services drawn congregations. a vigil for victims at tree of life, beginning with a somber moment of silence followed by song and prayer. they were gathered for an area, on the street, cordoned off by police and cones. shabat was held at the nearby temple. 97-year-old rose malinger was buried on friday. her 61-year-old daughter...
for good because sean hannity is live from new york right now. >> sean: two things are never going to do in life, two shows. jeopardy, am great at home and i'll blow it at person. and i'm not doing your quiz show, ever! >> tucker: why? never say never. >> sean: whom i going to lose too? it wouldn't be fun. great show. >> tucker: [laughs] >> sean: welcome to "hannity." this is the biggest abuse of power, corruption scandal in modern u.s. history. throughout the hour we will break it all down. information i promise you will not get anywhere else. it is not as complicated as they are making it elsewhere. in other words, the mueller which hutch should put real fear in the heart of every law-abiding citizen. every american. doesn't matter where your politics are. there is no equal justice under the law. there is no equal application under the law. the blatant political bias around every turn. we are criminalizing political differences in america. my dangerous president is being set now and mueller, he's not only on a mission. he is on a crusade to destroy, delegitimize, the donald trump
for good because sean hannity is live from new york right now. >> sean: two things are never going to do in life, two shows. jeopardy, am great at home and i'll blow it at person. and i'm not doing your quiz show, ever! >> tucker: why? never say never. >> sean: whom i going to lose too? it wouldn't be fun. great show. >> tucker: [laughs] >> sean: welcome to "hannity." this is the biggest abuse of power, corruption scandal in modern u.s. history....
a little lower for the parade. that is what we are talking about in new york city. in the west the system moves in, the northwest, northern california, central california, quite a bit of rainfall and snow. this is a good news situation but we see the threat for mudslides. and very cold in the northeast. by the way thanksgiving. i'm putting you on the spot. >> can put us on the spotlight that. >> the news cycle is sometimes depressing. and a lot of gray skies, now is the time to be grateful and thankful. i wrote the top 10 things i most thankful for on foxnews.com, and if you write down what you're grateful for it makes you happy. i am happy for these big strong legs and arms that i can wrap my family around, thankful for you guys and my health. and i encourage you and everyone at home to write something. rob: a lot of people only think about what they don't have but not what they do have and that is a problem. thanks so much. jillian: i'm thankful for you. we love you. rob: florida officials certify election results today, finally coming two weeks after recount chaos in key races.
a little lower for the parade. that is what we are talking about in new york city. in the west the system moves in, the northwest, northern california, central california, quite a bit of rainfall and snow. this is a good news situation but we see the threat for mudslides. and very cold in the northeast. by the way thanksgiving. i'm putting you on the spot. >> can put us on the spotlight that. >> the news cycle is sometimes depressing. and a lot of gray skies, now is the time to be...
Fox and Friends Saturday : FOXNEWSW : November 3, 2018 3:00am-7:00am PDT
punching a man in a face over a parking spot happened outside his home in new york city. the president reacting to the president's arrest. >> i wish him luck. [laughter] katie: baldwin denies the allegations and is in court november 26th right after thanksgiving. the habitual hot head has regularly gotten into the law including scuffles with paparazzi and screaming matches with reporters. those are your headlines. ed: he said the democrats have spent almost two years to put the real president in jail they have been unsuccessful. the fake president from "saturday night live" will be going to jail. pete: they should do an snl skit on that. ed: chances of that are zero. pete: midterms three days away. next guest breaks down three races that could surprise everyone on november 6th. ed: jane fonda, see how hanoi jane is reaching back in history to yes, of course, take a swipe at president trump. ♪ when the roof caved in ♪ and the truth came out ♪ what do you look for when you trade? i want free access to research. yep, td ameritrade's got that. free access to every platform. yeah, tha
punching a man in a face over a parking spot happened outside his home in new york city. the president reacting to the president's arrest. >> i wish him luck. [laughter] katie: baldwin denies the allegations and is in court november 26th right after thanksgiving. the habitual hot head has regularly gotten into the law including scuffles with paparazzi and screaming matches with reporters. those are your headlines. ed: he said the democrats have spent almost two years to put the real...
Fox and Friends Sunday : FOXNEWSW : November 4, 2018 3:00am-7:00am PST
," voters set to render fresh verdict on trump. so, two things strike me, one, in the "new york times" headline, a nation in turmoil. is there division? sure. even the ap is saying we have a vibrant economy. that's a good deal number one. and number two, both of these talk about the same word to talk about the president. verdict. verdict for trump, as if it's sort of a criminal. pete: nice big and bold. you know why? because they have been putting him on trial since the beginning of his presidency. think about the context of that. they want the voters to religion der a verdict that the fake news media hasn't been able to render for them. they are hoping that this blue wave that's now blue ripple even a red wall will indict this president in the way they haven't been able to. katie: if you look at the word turmoil. it's so dramatic, right? i think this is indictment again of the media bubble with all due respect that new york and washington, d.c. live in. if you go outlines of these places and you talk to people as "fox & friends" talks to people in these diners for breakfast with frie
," voters set to render fresh verdict on trump. so, two things strike me, one, in the "new york times" headline, a nation in turmoil. is there division? sure. even the ap is saying we have a vibrant economy. that's a good deal number one. and number two, both of these talk about the same word to talk about the president. verdict. verdict for trump, as if it's sort of a criminal. pete: nice big and bold. you know why? because they have been putting him on trial since the beginning...
Your World With Neil Cavuto : FOXNEWSW : November 23, 2018 1:00pm-2:00pm PST
. more on the markets in a minute. we have fox team coverage with kristina partsinevelos in new york city with what folks are buying and connell mcshane on long island. kristina? >> charles, i don't know about you but it's crazy out here. the store opened at 5:00 p.m. and closed at 1:00 a.m. and reopened again. clearly a lot of people behind me. they're restocking the shelves. have to give them credit. you can see how things are going out. people wanted to get the deals. if we're talking about the numbers, what does the national retail federation say? they expect an increase in 4.3% year over year this november. expecting sales to be strong this enough this is a time where i'm asking viewers, to get your pen and paper for the best deal. according to adobe analytics, you want to buy sporting goods. a good time today on black friday. if you're looking at apparel or appliances, do that sunday. this is according to adobe analytics. cyber monday, known for the best deals on toys. and travel tuesday. tuesday is supposed to be the best for flights. so you're wondering, i'm at a best buy. what ki
. more on the markets in a minute. we have fox team coverage with kristina partsinevelos in new york city with what folks are buying and connell mcshane on long island. kristina? >> charles, i don't know about you but it's crazy out here. the store opened at 5:00 p.m. and closed at 1:00 a.m. and reopened again. clearly a lot of people behind me. they're restocking the shelves. have to give them credit. you can see how things are going out. people wanted to get the deals. if we're talking...
admit most judges usually vote in a partisan way? the media pounding the president over a new york times report that he wanted to order the justice department to prosecute hillary clinton and jim comey. >> >> these are huge banana republic type territory. >> a defining moment in history of the trump presidency. this is a demonstration of his unfitness to be president of the united states, abuse of presidential power, embrace of authoritarianism. >> does that sound like breaking news to you because it isn't, it shouldn't and because we know how the president feels about hillary and comey and we know hillary committed crimes. it is not even in dispute. >> given the president took no action has coverage on overboard. thunderous media condemnation for backing saudi arabia after his owns cia ordered the -- saver prince ordered the murder of jamal khashoggi. is he ignoring evidence the following past precedent in cooperating with a murderous regime? the next white house correspondents dinner, and offer, not a comedian because last year's train wreck. >> if a tree falls in the woods, how do we
admit most judges usually vote in a partisan way? the media pounding the president over a new york times report that he wanted to order the justice department to prosecute hillary clinton and jim comey. >> >> these are huge banana republic type territory. >> a defining moment in history of the trump presidency. this is a demonstration of his unfitness to be president of the united states, abuse of presidential power, embrace of authoritarianism. >> does that sound like...
The Ingraham Angle : FOXNEWSW : November 29, 2018 11:00pm-12:01am PST
case has already been -- the mueller case has already been reassigned to the new york judge who handled his original case. the sentencing range in this case in new york was with the southern district, 46 to 57 months. could be as high as 63 months. by consolidating these for sentencing, he has the potential to get probation. mueller is giving him a 5k1 for cooperation. they are consolidated for sentencing. the judge in the new york case in the southern district case will sentence together, there's a whole grouping concept in the guidelines at the end of the day can say your cooperation with mueller was so great, you are going all the way down to probation. his attorneys could argue for that anyway but when you have a 5k1 from the government, it's a huge thing. keep your eye on that. >> laura: we are working on booking him. we would prefer to interview him in studio or not jail. thank you. the left is quick to take the president as being anti-semitic. the most ridiculous thing ever, no evidence at all. but they have blinders on when it comes to some of the most violent elements o
case has already been -- the mueller case has already been reassigned to the new york judge who handled his original case. the sentencing range in this case in new york was with the southern district, 46 to 57 months. could be as high as 63 months. by consolidating these for sentencing, he has the potential to get probation. mueller is giving him a 5k1 for cooperation. they are consolidated for sentencing. the judge in the new york case in the southern district case will sentence together,...
york and hollywood, doing news reports because you guys are doing your job. and they are not getting combat pay. and jeff flake, like you said, it is a stunt. brian: he will say anything to make the president look bad on his way out. we did this 100 years ago, in 1916, always did this, when times of trouble you put your troops on the border. not be arresting people, supporting border patrol. allowing border patrol to do what they can do. pete: the secretary of defense in texas and yesterday on the program we told you how hundreds of migrants arriving in the tijuana area. close to 800 have arrived, they were set up so migrants waiting to apply for asylum or trying to figure out what they are doing in the new york times. if they get caught they will be deported. some of the images from wednesday where they are looking to the united states. ainsley: the razor wire forms large rails like an accordion. and the migrant workers, in the border patrol agent. >> the problem for tijuana, they are camped out in tijuana. scores of people in the shoulders, not hundreds and not thousands and they a
york and hollywood, doing news reports because you guys are doing your job. and they are not getting combat pay. and jeff flake, like you said, it is a stunt. brian: he will say anything to make the president look bad on his way out. we did this 100 years ago, in 1916, always did this, when times of trouble you put your troops on the border. not be arresting people, supporting border patrol. allowing border patrol to do what they can do. pete: the secretary of defense in texas and yesterday on...
Outnumbered : FOXNEWSW : November 5, 2018 9:00am-10:00am PST
because it's an ugly day in new york. it's cold, it's raining. we were supposed to do the show outside. and we aren't. >> melissa: we snuck inside. >> harris: weren't you with us for wind gate at the convention? our harris flipping up and you could see who had a weave. not that it was you. >> chris: in cleveland? and we went off the air? yeah. >> melissa: i was here, i was the one who stayed on camera where you went for shelter. anyway, good times. moving on, president trump hitting three battleground states today. ohio, indiana, and missouri, after campaigning in tennessee and georgia yesterday. here is the president. >> this election will decide whether we build on this extraordinary prosperity that we have created. did you see the numbers on friday? did you see that? [cheers and applause] was a relet the radical democrats take a giant wrecking ball to our economy and to our future. >> melissa: in the meantime, former president obama slamming president trump's policies while campaigning for democrats at the rallies in chicago and gary, indiana yesterday. >> america is at a crossroads
because it's an ugly day in new york. it's cold, it's raining. we were supposed to do the show outside. and we aren't. >> melissa: we snuck inside. >> harris: weren't you with us for wind gate at the convention? our harris flipping up and you could see who had a weave. not that it was you. >> chris: in cleveland? and we went off the air? yeah. >> melissa: i was here, i was the one who stayed on camera where you went for shelter. anyway, good times. moving on, president...
moscow. rudy giuliani telling the new york times the president's response to the special counsel aligned with cohen's plea deal. michael cohen pled guilty to a crime but despite lack of evidence against donald trump, he is the one being prosecuted in the court of public opinion, the president is. molly hemingway, senior editor for federalist says it is outrageous that accountability has become a partisan issue. >> here's the person, find me the crime, we look for crimes and determine what should be done. we have evidence of also to criminal things, criminal leaking of classified information against trump officials, lying to a court that are not worried about by people who think just keep digging we can finally get trump. so few people held accountable for lying to congress even in the russia story, christopher steele who built the entire russia dossier and almost a year ago, he lied to the fbi. and testimony, the guy hired by hillary clinton to set up the russia story, gave testimony at odds meaning one or both of them lied to congress, look at james clapper who line about spy on
moscow. rudy giuliani telling the new york times the president's response to the special counsel aligned with cohen's plea deal. michael cohen pled guilty to a crime but despite lack of evidence against donald trump, he is the one being prosecuted in the court of public opinion, the president is. molly hemingway, senior editor for federalist says it is outrageous that accountability has become a partisan issue. >> here's the person, find me the crime, we look for crimes and determine...
Outnumbered Overtime With Harris Faulkner : FOXNEWSW : November 29, 2018 10:00am-11:00am PST
michael cohen about this moscow real estate proposal that never went through. as cohen left a new york court this morning he did not stop to take reported questions about the apparent conflict. in the draft for congress in 2017, cohen said negotiations over the trump-moscow project ended in january of 2016. they told a new york court today it was, in fact, five months later in june of 2016. in the draft, cohen's of the discussion about traveling to moscow was limited and it was never raised with then-candidate trump. but cohen told the new york court the discussions were, in fact, more extensive. on capitol hill a short time ago, the chairman and the ranking member of the senate intelligence committee -- that committee matters because they got the testimony from cohen in the first place. they reacted to the plea. >> i'm not going to comment upon that commentary of this into a jewel made before our committee. we have kept that confidential. obviously, he was one of the witnesses that we always wanted to have come back. that need to goes that. >> i haven't seen the specific indictment or the p
michael cohen about this moscow real estate proposal that never went through. as cohen left a new york court this morning he did not stop to take reported questions about the apparent conflict. in the draft for congress in 2017, cohen said negotiations over the trump-moscow project ended in january of 2016. they told a new york court today it was, in fact, five months later in june of 2016. in the draft, cohen's of the discussion about traveling to moscow was limited and it was never raised...
Fox News @ Night With Shannon Bream : FOXNEWSW : November 21, 2018 12:00am-1:00am PST
russia investigation, the president's legal team, special counsel robert mueller. new york times report claims donald trump wanted the justice department to prosecute hillary clinton and former fbi director james comey, don began saying what the president did he did not ask him to do. kristin fisher calling new developments on the saudi saga but katherine herridge has the mueller probe. >> reporter: the president's legal team issued a brief statement confirming the president's written responses are with robert mueller. significantly the questions dealt with russian related topics, the firing of james comey as part of an obstruction investigation. it has been our position from the outset that much of what has been asked raised serious constitutional issues and was beyond the scope of a legitimate inquiry. rudy giuliani said this remains our position today, the president has nonetheless, unprecedented cooperation. the team emphasized they had 30 witnesses, 1.4 million pages of material and now the president's written responses. shortly before confirmation from the legal team the pr
russia investigation, the president's legal team, special counsel robert mueller. new york times report claims donald trump wanted the justice department to prosecute hillary clinton and former fbi director james comey, don began saying what the president did he did not ask him to do. kristin fisher calling new developments on the saudi saga but katherine herridge has the mueller probe. >> reporter: the president's legal team issued a brief statement confirming the president's written...
. democrats from ohio, new york, colorado, south carolina, victor congressional races, filled by promising to oppose nancy pelosi. she is confident she will be the next speaker of the house. >> it is clear i will not be voting for the current leader. i am supporting change. >> house republicans dealt with the challenge in their ranks last night. the current number 2 california representative, kevin mccarthy, easily beat the founder of the freedom caucus, jim jordan, to become the next house minority leader. congress is back in session, notorious lame-duck session and lawmakers have a lot of legislation to consider, related to healthcare, national security, the border wall, protections for the special counsel, top of the list the spending bill. lawmakers need to pass it by december 7th to keep some agencies like the balance of homeland security up and running. 's for nancy pelosi she will hold her weekly press conference later this morning. democrats are set to vote on speaker in a couple weeks. a fox news poll, democrats against nancy pelosi, democrats behind the letter, trying t
. democrats from ohio, new york, colorado, south carolina, victor congressional races, filled by promising to oppose nancy pelosi. she is confident she will be the next speaker of the house. >> it is clear i will not be voting for the current leader. i am supporting change. >> house republicans dealt with the challenge in their ranks last night. the current number 2 california representative, kevin mccarthy, easily beat the founder of the freedom caucus, jim jordan, to become the...

redpajama_set_name: RedPajamaCommonCrawl


You've picked one of the best times to visit, as London's Autumn Season kicks off with a rich programme of culture. Totally Thames festival is a highlight of the season – over the month and along the 42 miles of the Thames, there is a host of activities as we celebrate our much-loved river. From beach walks to river tours, there are loads of ways to learn about the gateway to our city.London has always prided itself on being a global sporting capital.
American football comes to the capital as the NFL holds its London Games Series at Wembley Stadium. Watch the Baltimore Ravens take on the Jacksonville Jaguars and the New Orleans Saints compete against the Miami Dolphins. Meanwhile, more than 700 venues open their doors and welcome visitors during Open House London, which marks 25 years. This is your chance to explore the unexplored and see inside some of London's amazing buildings – take a tour around City Hall and enjoy the views of the City and Tower Bridge. Have a great time in London!


The Center for Drug Discovery (CDD) at Northeastern University is dedicated to the discovery of novel medications and to the development of approaches and technologies aimed at improving the discovery of new therapeutic drugs. The CDD also incorporates a unique educational component to train new scientists in the multidisciplinary field of drug discovery.
Develop novel methodologies to improve drug discovery efficiency and success.
Discover new medications to satisfy important medical needs.
Train students and post-doctoral fellows in the art and science of drug discovery.
Collaborate extensively with the biotechnology and pharmaceutical industries and leading clinical centers for translational biomedicine.
The CDD houses over 60 scientists, including faculty researchers, pre- and postdoctoral fellows, and students, in well-equipped, state-of-the-art laboratories to conduct research in the fields of medicinal chemistry, chemical biology, molecular biology, cell biology, tissue culture biochemistry, behavioral studies, proteomics, metabolomics, in vitro characterization, in vivo profiling, chemical synthesis, biophysics, radiochemistry, and imaging.
The CDD consists of several major lab groups at Northeastern University, covering a range of research fields.
Professor Makriyannis, Director of the CDD, has more than thirty years' experience in the study of the endocannabinoid system.
The chemistry side of the Makriyannis labs are responsible for the design and synthesis of thousands of novel ligands for the CB1 and CB2 receptors.
The Makriyannis lab is at the forefront of research into the newly discovered endocannabinoid transport system, including designing the first inhibitors of fatty acid amide hydrolase (FAAH).
The Makriyannis lab has recently developed a unique controlled deactivation 'switch' for cannabinoid compounds, research which was featured by the American Chemical Society and the National Institute for Drug Abuse.
A novel approach for studying the structural features involved in the interaction of a ligand with its target protein.
Chemists in the Makriyannis labs are able to design and synthesize highly selective ligands, capable of interacting covalently with a function protein (GPCR, enzyme, transport).
The ligand-protein binding motif is obtained through the use of protein mutants in combination with proteomic methods for characterizing the amino acid residues involved in ligand attachment at the protein binding site.
The information obtained is used to model the drug-protein complex by computer modeling, and the results are used as a basis for the design and development of new medications.
The Booth lab's research focuses on drug candidate translation to treat neuropsychiatric and neurodegenerative disorders, including psychoses, drug addiction, ADHD, autism, and Parkinson's and Alzheimer's diseases.
In addition to their use by CDD scientists and affiliated faculty, the CDD has several state-of-the-art instruments available for academic and industrial use.
nano-LC-4000 QTrap (Applied Biosystems) with an ESI source: this state-of-the-art instrument is the only hybrid quadrupole linear ion trap available on the market and it is extremely sensitive for both protein identification and characterization and small molecule quantification (NEU members $35/hour; Non-NEU academic $60/hour, Industry price $120/hour).
TSQ Quantum Ultra Triple Quadrupole (Thermo Scientific) mass spectrometer with both ESI and APCI ion sources: complete with an Agilent 1100 front end, this instrument has the widest linear dynamic range and highest sensitivity of any triple quad currently on the market, demonstrating detection of our compounds down to the femtogram level (NEU member $30/hour; Non-NEU academic $50/hour; Industry price $100/hour).
MALDI Tof/Tof (Applied Biosystems) with an Optibeam off-axis laser: an ultra-high-performance mass spectrometer, capable of detecting whole proteins up to 120 kDa, or complex protein digests with high resolution and mass accuracy. The Optibeam on axis laser provides ten times greater sensitivity compared to the previous model, which aides in the detection of low abundance peptides (NEU member $35/hour; Non-NEU academic $60/hour; Industry price $120/hour).
700 MHz 4-channel NMR spectrometer: Capable of carrying out all modern one- and multi-dimensional NMR experiments including a suite of the TROSY version triple resonance experiments for 15N-, 13C- and 2H- triple labeled protein samples, with variable temperature multinuclear probes and gradient capabilities and operating both in solution and solid-state modes (NEU member $50/hour ($100/day, $250/weekend); Non-NEU academic $75/hour ($300/day, $750/weekend); Industry price $150/hour ($600/day, $1500/weekend)).
400 MHz 4-channel wide-bore Bruker NMR spectrometer: dedicated for solid-state NMR experiments and solution experiments, with a versatile multinuclear BBFO solution probe, this instrument is equipped with a wide-line probe and two specialized triple resonance HXY and HFX CP-MAS probes. It also runs the most advanced Rotational Echo Double Resonance (REDOR) and double REDOR experiments (NEU member $25/hour ($100/day, $200/weekend); Non-NEU academic $50/hour ($200/day, $500/weekend); Industry price $100/hour ($400/day, $1200/weekend)).
As part of its didactic component at Northeastern University, the CDD trains a number of graduate students in drug discovery and design.


Children's Hospital of Boston, Boston, MA 02115, U.S.A.Channing Laboratory, Boston, MA 02115, U.S.A.
Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital, Boston, MA 02115, U.S.A.
Channing Laboratory, Boston, MA 02115, U.S.A.
Among the antimicrobial proteins and peptides of humans is the cationic 55 kDa bactericidal/permeability-increasing protein (BPI), which possesses antibacterial, endotoxin-neutalizing and opsonic activity against Gram-negative bacteria. Although identified originally as an abundant constituent of neutrophil granules, we have recently identified functional expression of BPI by human mucosal epithelia. BPI expression was markedly up-regulated by exposure of epithelia to lipoxins, endogenous anti-inflammatory eicosanoids that are generated in vivo in the context of aspirin treatment (aspirin-triggered lipoxins). Epithelial BPI was found to be surface expressed and fully functional, as measured by antibacterial activity against Salmonella typhimurium as well as lipopolysaccharide (LPS; endotoxin)-neutralizing activity. These results suggest a role for BPI as an effector of epithelial antibacterial activity and as a modulator of epithelial responses to LPS. Both BPI and the lipoxins are currently the subject of intensive biopharmaceutical development, raising the possibility that therapeutic use of BPI or modulation of epithelial BPI expression may be a useful adjunctive therapy for conditions in which epithelial inflammation is associated with Gram-negative infections and/or endotoxin.
Abbreviations used: ATLa, 15-epi-16-(p-fluoro)-phenoxy-lipoxin A4; BPI, bactericidal/permeability-increasing protein; LBP, lipopolysaccharide-binding protein; LPS, lipopolysaccharide; LXA4, lipoxin A4; PLUNC, palate, lung and nasal epithelium clone; TLR, Toll-like receptor.