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Articles Posted in Personal Injury Claim
Former CBS Chief Moonves Accused of More Sexual Misconduct
An internal investigation of former CBS chief Les Moonves has apparently turned up more evidence of sexual misconduct, as well as lying and destruction of evidence, throwing into jeopardy his $120 million severance package, according to the most recent reports.
Here is what's known about the scandal so far:
Moonves, 69, largely credited with turning CBS around, was forced out in September, after The New Yorker published allegations from 12 women who said he subjected them to mistreatment that included forced oral sex, groping and retaliation if they resisted.
Moonves denied the accusations, though he said he had consensual relations with some of the women.
Lawyers hired by the network allege in a draft report that the TV executive committed "multiple acts of serious non consensual sexual misconduct" before and after he came to CBS in 1995. The report goes on to allege that he deleted numerous text messages and was "evasive and untruthful at times" under questioning.
Investigators claim they received reports about a network employee who was "on call" to perform oral sex on Moonves. Investigators also allege that he received oral sex from at least four CBS employees "under circumstances that sound transactional and improper to the extent that there was no hint of any relationship, romance, or reciprocity."
The investigators say they interviewed 11 of the 17 women they knew had accused Moonves of misconduct and found their accounts credible.
The 59-page report is to be presented to CBS's board of directors before the company's annual meeting next week, according to reports.
The former CEO "vehemently denies having any non-consensual sexual relations. He never put or kept someone on the payroll for the purpose of sex," according to reports.
Sexual harassment can encompass a variety of unwanted actions. This can include sexual advances, inappropriate touching, patting, pinching, groping, or leering. Unsavory comments made by your boss or co-workers about your body, appearance, sexual orientation, sex life, or your clothing is also a form of sexual harassment.
In the state of Florida, you have the right to work at your job without being sexually harassed by your co-worker, supervisor, boss or anyone else. You are also awarded the right to report any sexual harassment without being retaliated against by your employer.
Being forced to endure sexual harassment at work is damaging to your mental and physical well being, which can cause destruction to all aspects of your life. At Whittel & Melton, our Florida Sexual Harassment Attorneys understand sexual harassment laws and can develop a strategy to help you recover compensation for your suffering.
Posted in: Employment Law, Florida, Personal Injury Attorney, Personal Injury Claim and Sexual Harassment
Former Orlando Vacation Employee Alleges Pregnancy Discrimination
An Orange County woman is suing a vacation business, alleging discrimination, retaliation and wrongful termination.
The woman filed a complaint Oct. 17 in Orange County Circuit Court against Wyndham Vacation Ownership Inc., alleging violation of the Orange County Civil Rights Ordinance and the Family Medical Leave Act.
According to the complaint, in February the woman requested leave due to complications with her pregnancy. Prior to returning to work on or around March 7, the suit says, she was terminated for alleged poor performance.
The woman says she has suffered lost wages and benefits, emotional pain and suffering, humiliation, inconvenience, mental anguish and loss of enjoyment of life.
She alleges Wyndham Vacation Ownership subjected her to pregnancy-based discrimination and harassment and retaliated against her by terminating her employment for exercising her rights.
In regards to pregnancy, it is illegal for an employer to discriminate against a woman because she is with child. State and federal laws protect women against this form of discrimination in all aspects of employment, including interviewing, hiring, firing and promoting.
Pregnant employees may suffer from a variety of medical conditions during pregnancy and after childbirth. It is illegal for employers to discriminate against these employees. Some examples of medical conditions related to pregnancy or childbirth include:
Any conditions that require bed rest
Lactation issues
Posted in: Discrimination Lawyer, Employment Law, Personal Injury Attorney, Personal Injury Claim, Pregnancy Discrimination and Wrongful Termination
Updated: November 1, 2018 8:15 pm
Florida's First District Court of Appeal Overturns Workers' Compensation Claim
The Florida First District Court of Appeal has overturned an order in a workers' compensation case, ruling that a worker forfeited his right to benefits for a workplace accident after he offered conflicting details about his medical history and the cause of his injuries.
Cal-Maine Foods had appealed the ruling by the Judge of Compensation Claims (JCC) to reject multiple defenses to compensability of a work accident and related benefits.
The case originated from an accident that occurred on Nov. 2, 2014. A man was working for Cal-Maine Foods when the brakes failed on a front-end loader he was driving. He jumped from the machine and was injured.
There was conflicting testimony as to whether the man reported any injuries to the company at the time of the accident.
Cal-Maine later fired the man for reasons unrelated to the accident.
In August 2015, following the termination, the man filed a petition for benefits, seeking payment of temporary total disability or temporary partial disability benefits and authorization of a neurological/orthopedic physician to evaluate and treat his lower back symptoms.
The man listed the November 2014 accident as the basis for the injuries.
During his first deposition in May 2015, the man testified that the injuries resulting from the work accident included a broken nose, orbital fractures, concussion with brain injury and herniated discs of the neck and lower back. He requested surgery for facial fractures and treatment for his neck and back.
In his testimony, the man said that when he jumped from the machine, he hit his left shoulder on the rear left tire, which spun him around causing him to strike his face on asphalt. He described injuries specifically to the right eye and socket as well as bleeding scrapes over his left eye.
During a second deposition seven months later, the man gave sworn testimony that his injuries from the accident included the eye socket, nose, neck, middle and lower back. However, he advised that as of the second deposition, his nose and eye injuries had healed. He complained of constant neck pain.
The man didn't seek medical treatment after the accident. He waited until a month after his termination, which occurred two months after the November 2014 accident.
The man received initial medical treatment on Jan. 22, 2015 at Shands Hospital. He claimed to have a head injury and pain that affected his memory and resulted in a headache after he was hit in the head with a baseball bat eight days before coming to the hospital.
During the second deposition when confronted with the hospital records, the man testified that his description of the baseball bat incident was false and contrived. He asserted he later "corrected" this false account and told the hospital staff the injuries actually occurred from an accident at work.
On Feb. 4, 2015, the worker proceeded to the Wesley Chapel Hospital Emergency Room, where he was seen for facial pain, advising medical personnel that he received a facial fracture "one month earlier."
The man requested pain medications and denied back pain or headaches. He did not report a work accident.
In March 2015, the man was evaluated by a neurologist. He complained of neck, middle and lower back pain and confusion due to the work accident. At that evaluation, he denied any history of neck or back pain or similar injuries before the accident. He didn't mention the baseball bat incident.
On Nov. 11, 2015, the man got an examination from a neurosurgeon. He complained of pain radiating down his right leg, lower back, cervical spine, shoulder and right facial pain. During this evaluation, he claimed the Nov. 2, 2014 accident was the source of his symptoms.
Although the JCC determined that the man had committed multiple misrepresentations in his testimony, the JCC ultimately declined to terminate his entitlement to workers' compensation benefits. The appellate court, however, disagreed and reversed its ruling.
Each year, thousands of people are involved in work-related accidents in the workplace. In many cases, these injuries can have serious financial consequences in addition to creating health issues that could keep employees from earning a living and supporting their families for certain periods of time.
Posted in: Employment Law, Florida, Personal Injury Attorney, Personal Injury Claim and Worker's Compensation
American Family Insurance To Pay $20 Million In Damages For Discrimination
On Friday, a Jackson County Circuit Court jury awarded $20 million in punitive damages in a case that alleged retaliation, age and sex discrimination against an American Family Insurance sales manager.
The plaintiff, a 60-year-old woman of Blue Springs, brought the case against the company and a former Missouri state director of the company who supervised her.
The woman continues to be an American Family agent after she was removed from her manager position in a corporate restructuring.
A spokesman for American Family said Monday that the company strongly disagrees with the verdict "and believe it is contrary to the facts and testimony that were presented at trial."
The media relations director for the company said: "We do not illegally discriminate in any way, and there was no discrimination in this situation. We are considering our options for appeal."
Attorneys for the woman said they believed the jury agreed that she was targeted as part of a corporate movement to let older workers go and hire younger ones.
The plaintiff's case included testimony that the woman was an award-winning sales manager and had produced results on par with or better than her peers who were younger and mostly men.
The jury also awarded $450,000 in actual damages.
There are many Federal and Florida laws and statutes that all prohibit discrimination in the workplace. In Florida, employers cannot discriminate against employees on the basis of race, sex, religion, national origin, physical disability, or age.
The law prohibits any such discrimination in hiring, firing, promotion, job assignment and pay. Employment discrimination can encompass many different things. Rude jokes, failure to promote, and reasons for termination can all constitute discrimination.
Posted in: Employment Law, Florida, Personal Injury Attorney and Personal Injury Claim
Nearly 10,000 Employees Sue Chipotle For Wage Theft
Nearly 10,000 workers are suing Chipotle for allegedly not paying them the money they are owed.
Current and former Chipotle employees claim that the company made them work extra hours "off the clock" without paying them. This is called wage theft, and Chipotle is accused of doing this all over the United States.
"Chipotle routinely requires hourly-paid restaurant employees to punch out, and then continue working until they are given permission to leave," according to the class action lawsuit known as Turner v. Chipotle. It's named after a former Chipotle manager in Colorado who claims she had to work without pay and was told to make workers under her do the same in order to meet budget goals.
Chipotle denies any wrongdoing and says the case has no merit. The company said it has paid all wages it owes employees.
Chipotle has faced similar lawsuits previously, but this is the first time there has been such a large class action case against the company for wage theft. As of Friday, 9,961 current and former workers have sent in consent forms to join the lawsuit.
Chipotle is expected to continue fighting the case.
Employers expect employees to do their assigned tasks, plain and simple. Employees expect to be paid their agreed upon wage for all hours worked, equally as simple. However, sometimes employers fail to live up to their end of the obligation. When employers fail to pay workers the full and fair wages they are entitled to receive, employees can take legal action, as this case shows.
Posted in: Employment Law, Florida, Personal Injury Attorney, Personal Injury Claim and Unpaid Overtime
Chicago Lawyer Accuses Her Firm Of Gender Discrimination
A lawyer in the Chicago office of Sedgwick has sued the firm for gender discrimination, unequal pay and retaliation.
The insurance lawyer, alleged in a lawsuit filed in California that female attorneys "cannot crack the glass ceiling of equity partnership at Sedgwick."
The San Francisco-based firm has more than 300 lawyers, 26 in Chicago, and last year booked $183.0 million in revenue. In the suit, the woman described being publicly singled out in a meeting by a powerful partner who recommended lowering her pay because she "needed to learn to behave."
"Sedgwick's male-dominated culture systematically excludes women from positions of power within the firm, which in turn leads to lower compensation for female attorneys as compared to male attorneys," the lawsuit says.
The firm retaliated against the woman after she filed a complaint with the Equal Employment Opportunity Commission in February, seeking to force the dispute into private arbitration, the lawsuit says.
The firm is "confident there has been absolutely no discrimination or retaliation in the partner compensation process or otherwise, and we will defend the firm against these baseless allegations."
This woman is not the first to accuse a firm of discrimination. In January, a former partner at LeClairRyan sued in January in Virginia alleging unequal pay and retaliation. In 2013, Greenberg Traurig settled a class-action brought by female attorneys.
While this case is in California, our Florida Discrimination Lawyers at Whittel & Melton know the issue of unequal pay is a widespread problem that affects women across the country.
A recent compilation by the Bureau of Labor Statistics shows that women face unequal pay in most industries. An average for all full-time and salary workers shows median weekly wages for men being $895 and $726 for women. For marketing and sales managers: men- $1,603 and women – $1,258. For human resource workers: men – $1,158 women – $984. For personal financial advisers: men – $1,738 women – $1,033. Sadly, the gender pay gap is reportedly worse for mothers and older working women.
Posted in: Discrimination Lawyer, Employment Law, Florida, Personal Injury Attorney and Personal Injury Claim
3 Walmart Employees Charged in Death of Shoplifter
Lakeland police have arrested and charged three Walmart employees with manslaughter in the February death of a shoplifter.
Police said just after 3 a.m. Feb. 7, a 64-year-old man stole nearly $400 worth of DVDs and ran when he was confronted by employees.
The employees chased him down and at some point, the man fell to the ground and was held there by the employees.
The man stopped breathing and the employees called 911. He was transported to the hospital in critical condition, but later died.
During an investigation, the Medical Examiner determined the man died of mechanical asphyxia due to restraint and that the man had 15 broken ribs.
The three Walmart employees charged were a 35-year-old support manager, a 23-year-old customer service manager, and 58-year-old employee for loss prevention.
Walmart issued a statement Friday afternoon:
Our hearts go out to everyone affected by these events. The status of the associates involved continues to be reviewed. We'll continue working with law enforcement officials, as we have from the beginning, while conducting our own review.
If it can be demonstrated that Walmart's employees used an unreasonable amount of force, or acted unreasonably in detaining the suspected shoplifter, they could face liability for wrongful death and even false imprisonment in a lawsuit by the deceased man's relatives.
Employers must be cautious about what their employees do in regards to shoplifters because employers may be legally responsible for the harm caused by their employees' actions. Customers, including shoplifters, may be able to hold the employer liable when they suffer injuries or are harmed by employees or wrongfully detained by employees for suspicion of shoplifting.
As this case shows, it is possible to hold the employee's legally responsible for their actions, but usually employers are the target of lawsuits because they have bigger insurance policies than their employees, which means if they are successful in proving their claim, they will receive a larger financial settlement.
Posted in: Employment Law, Florida, Personal Injury Attorney, Personal Injury Claim and Wrongful Death
50 Former Wrestlers Sue WWE
More than 50 ex-wrestlers have filed a Connecticut lawsuit stating that World Wrestling Entertainment Inc. is responsible for their long-term neurological damage and failed to care for their injuries.
Jimmy "Superfly" Snuka, Joseph "Road Warrior Animal" Laurinaitis and Paul "Mr. Wonderful" Orndorff are among the plaintiffs who filed suit Monday in federal court in Connecticut against Stamford-based WWE.
WWE denies the allegations. They said that an attorney for the ex-wrestlers previously has made false claims against the company and filed lawsuits that ended up being dismissed.
The plaintiffs allege they suffered concussions and other head trauma that resulted in long-term brain damage.
Snuka is charged in the 1983 death of his girlfriend near Allentown, Pennsylvania. He has been ruled mentally incompetent to stand trial, and his defense partly blames head trauma suffered in the ring.
Repetitive or single blows to the head can cause concussions, something that is commonly referred to as traumatic brain injuries or TBIs. These hits to the head can cause a degenerative disease called chronic traumatic encephalopathy – CTE. CTE happens when repetitive head trauma results in the production of abnormal proteins in the brain known as "tau." Tau proteins essentially knot the brain's blood vessels, which can disrupt normal functioning and will eventually kill nerve cells.
Early stages of CTE involve memory loss, disorientation, rage, confusion and dizziness. As the disease progresses, more symptoms appear, including poor judgement and dementia. In severe cases of CTE, you can see impaired speech, vertigo, tremors and deafness.
Posted in: Employment Law, Florida, Personal Injury Attorney, Personal Injury Claim and TBI
Disney Worker Fired, Rehired Over Tweet About Alligators
A Disney College Program participant working in Magic Kingdom restaurants was fired and subsequently rehired after she Tweeted a picture of a sign posted in the breakroom regarding gators.
If guests ask whether there are alligators in the water around the Magic Kingdom's Tom Sawyer Island, the sign told employees, the correct answer is: "Not that we know of, but if we see one, we will call Pest Management to have them removed.' Please do not say that we have seen them before."
She tweeted out a picture of the sign, which was typed on paper in several different colors
Disney quickly removed the sign, which the company had not authorized to be posted. Around the same time, the female was fired.
The Orlando Sentinel inquired about the girl's termination on Thursday evening. On Friday morning, Magic Kingdom Vice President Dan Cockerell paid a personal visit to Sullivan to offer her the job back. She will return to work until later this month, when her internship was originally scheduled to end, according to reports.
When visitors ask about alligators, Disney said it has advised workers to acknowledge that parts of the theme-park resort can attract wildlife. They are also supposed to tell guests to notify security if they see any alligators.
Disney said it does not know who posted the sign and that no one else is being disciplined over the incident. Cast members were trying to do the right thing, the company said.
"We do not want our Guests to be afraid while walking around Frontierland," the sign read.
The female staff member said she knew sharing a picture of the sign on social media might get her in trouble, but she was bothered by the idea of misleading visitors.
She said a manager confronted her Thursday with the tweet, told her that her College Program stint would end early and took her identification. She was then escorted from the park.
Awareness of alligators has been heightened after one snatched a 2-year-old from the shore of Seven Seas Lagoon last month, dragging him into the water and killing him. Since then, many guests have come forward with stories of Disney gator sightings.
Emails obtained by the Orlando Sentinel this week showed Disney firefighters had been admonished for feeding alligators on the property.
The Rivers of America around Tom Sawyer Island is one place where people have spotted alligators in the past.
While just about everyone has their own Facebook, Twitter, Instagram, blog or any other type of social network account, you are ultimately responsible for what you post and who sees it. No matter what social networking site you are posting on, you have to be careful about what you write and choose to share with the public at large. You could be terminated for entries that your employer may read and does not like or agree with. However, there are certain limits to what an employer can do regarding posts that employees make during their own private time away from the workplace.
Posted in: Amusement Park Injury, Employment Law, Florida, Personal Injury Attorney and Personal Injury Claim
Worker in Zellwood Mushroom Plant Crushed By Pallets
A Tavares man was killed after being crushed by pallets of dirt and mushrooms at a Zellwood processing plant.
The 45-year-old man was moving pallets with a forklift late Monday night — some weighing between 800 to 1,000 pounds — at Monterey Mushrooms on Sadler Road when the stack of trays started shaking, according to an Orange County Sheriff's Office report.
The man jumped off the forklift and tried to run, but the pallets fell on him, according to a witness.
He was taken to Florida Hospital Apopka, where he was pronounced dead.
Deputies and the Occupational Safety and Health Administration are investigating.
Monterey Mushrooms has not released a statement.
The aftermath of a crush injury can be devastating. Sadly, crushing accidents are one of the top killers when it comes to workplace accidents. Because of the serious nature of these injuries, employers have an obligation to make sure that their workers are protected from crush injuries at all times.
Posted in: Employment Law, Lake County, Personal Injury Attorney, Personal Injury Claim, Worker's Compensation and Wrongful Death


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Manfred Perfler is an Italian para-alpine skier.

He won the bronze medal at the Men's Giant Slalom B3 event at the 1988 Winter Paralympics and at the Men's Slalom B3 event at the 1994 Winter Paralympics. He also competed at the Men's Downhill B3 event but did not finish.

References

Living people
Place of birth missing (living people)
Italian male alpine skiers
Paralympic alpine skiers of Italy
Alpine skiers at the 1988 Winter Paralympics
Alpine skiers at the 1994 Winter Paralympics
Medalists at the 1988 Winter Paralympics
Medalists at the 1994 Winter Paralympics
Paralympic bronze medalists for Italy
Paralympic medalists in alpine skiing
1963 births
20th-century Italian people

redpajama_set_name: RedPajamaWikipedia


The Solid Ocean Fractal is a fractal in Fractals of the Mists, which is only available at the end of even-numbered levels in addition to the previous three fractals the party must complete. The area has a Jade Sea theme from the original Guild Wars. This guide will tell you what you will be up against, what to do when you're in the midst of it and how to get through it with flying colors. In no time you'll be getting your daily fractal chests without even breaking a sweat when facing down the Jade Maw.
The Solid Ocean Fractal is a unique fractal in that it's always the last fractal you'll do when doing an even numbered fractal. You will always go a specific path and you will always face the same end boss. The difference between pre-10 difficulty and post-10 is only the Jade Maw's Agony and the amount of monsters you will face. Don't confuse the near repetition of the Fractal to be easy. however, if your party is unprepared for this, it will definitely be a disaster.
If you want to get all the achievements of Fractals, then be careful that as soon as you enter the Fractal, it is time to turn around and get to handle the mobs behind you, including the crabs. For the "Open Grave" achievement you need to get down all the mobs.
If you have a melee weapon, it will be very helpful to get this done more fluently, as half of the mobs you will face will have a permanent reflection aura. Right before you get to the open area with the Jade Maw you will have gained the achievement if you managed to kill all the crabs and mobs.
If you're looking to get this fractal done quickly for another run, you can easily run past all the mobs to get to the area with the Maw. It is important to note that you will need a melee weapon, though, as you will still have some Jade Colossus who will reflect projectiles back at you. If you're doing post-10 difficulty you will want to keep Agony Resistance gear at hand, as its Agony attack is unavoidable.
When facing the Jade Maw it can seem pretty overwhelming, but keep a few tips in mind when handling this boss.
After destroying two initial Veteran Jade Maw Tentacles, a swarm of Veteran Jade Colossus and additional tentacles will spawn. The Jade Maw will then periodically place a skull icon on a random target (including downed players, minions, pets, turrets and illusions) to focus a devastating beam attack. Any player that receives the skull icon must pick up a Reflecting Crystal (dropped from Colossus and tentacles) to absorb the beam and then redirect it back at the Jade Maw for massive damage.
The Jade Maw will unleash a final beam attack that quickly spreads around the fragment near its death.
You can avoid the Jade Maw's beam attack with abilities like Distortion or Elixir S. The attack can also be dodged.
The Agony applied by the Maw's phase transitions lasts for 9 seconds ticking 9 times in total.
Jade Maw is the only boss in Fractals of the Mists that has Agony which cannot be avoided by any means.
At the time you stand on the ground of the Jade Maw arena, stick to the left "wall" and run up towards a ledge behind the tentacles. Reach to the right ledge, and then you will be able to get behind the Maw's mouth and position to a far ledge. From here you can range down both of the Tentacles to truly get the fight started.
In the starting area of the Jade Maw arena are a series of blocks. Here you will have a base to draw Jade Colossus into and where tentacles can't hit you. You can gather the reflection crystals as many as you can and place them in this safe location. There's no requirement to permanently carry a reflection crystal, but instead stay close to them as you'll have more than enough time to pick up a crystal if they're nearby. If you don't pick up the crystals, they will despawn every few minutes.
Be attention that when the Maw is going to die, it will target all players with the skull and do a suicide laser attack that hits everything.
At least one person needs to avoid instant death by grabbing a crystal. But the fight has a bug. Even if all players are holding crystals there is a chance some (or even all) will still die. To circumvent this, your group needs one member to start running towards the Jade Maw immediately after picking up a crystal. It is said that the above laser attack can be completely avoided (with or without a crystal) if standing directly underneath the Maw.
If all players wipe, the entire fight is reset to its original settings. The fight has also been reported to reset if the only surviving member goes too far from the central area before the chest appears. It may be circumvented by waiting for the chest to appear, before reviving dead party members.


Comments: An amusing game for its simplicity and cheesyness. In the same series as many of the Pulsonic games in which Bandai, Mego, Epoch, Tandy, and Sears all released versions of games based on this hardware.
Just look at this course! The only control is the golfball button - the longer you hold it down, the farther the LED ball will proceed down the course.


A t-shirt with a black words "Fredericksburg Virginia" printed on the front upper corner. On the back (shown in main image) is a large printed image of the historical Fredericksburg skyline with the words "Fredericksburg, VA Chartered 1728." Available in 3 colors: Chalky Mint (shown), Bright Salmon, and Grey. Adult sizes Small, Medium, Large, and X-Large.


Florence's infamous Calcio Storico, also known as Gladiator Football. It takes place over two weekends in Piazza Santa Croce. A bone crunching experience for both 27 men teams, where all tactics are allowed to get the ball to the oppositions goal. The Azzurri and Bianchi teams do battle, Italy.


Are you looking for new and ingenious ways to bring more patients into your dental practice for growing it rapidly?
Here are some dental marketing ideas you might find useful.
Before going to a doctor most people check online as it is the easiest way to explore the options. A well-formed website of your clinic or chamber will bring you a lot more patients than those without a website. A website works best for attracting new patients online. Make the website easy to reach and use to encourage patients.
To keep your name at the top of the current patients' minds, encourage them to tell others about your services. This encouragement can be extra service or free service for each new patient. Or each new patient brought by the referral of an old patient can gain him some points he can use for services later. This way the number of patients coming your way will increase rapidly.
You can also run a referral campaign in a more organized way to encourage referrals. Create a referral page on your website for those who are already your patients. Mention the bonus points and free service they might win by referring you to the people looking for a dentist. Try to spread the word through your social channels. You may also adopt some paid marketing tricks to make it reach a larger audience. However, always make your referral campaign a truly cross-platform one.
Professional referral network is a great way to get more patients for your dental practice. Attend various gatherings and programs of professionals. You can have deals with other professionals of referral exchange. Good professional relationship with physicians in other fields can get you many new patients through referrals. You can visit NetProReferral for easily creating a good professional referral network.
Social media is a very good option to reach patients. Have professional accounts on different social media and update those often. Interactions with one potential patient on social media will gain you more patients by bringing you to their homepages. Besides, you should also keep updating your followers with updated info regarding oral health and wellbeing on your social channels.
Host online and real-life events on dental practices. You can offer free services for those who attend the program. They will eventually spread the word and you'll gain more patients. Don't forget to post the pictures of the event on social media. You can also attend events organized by other professionals. Through such events you will be able to meet new people and eventually enlarge your referral network. Hosting events for your referral network is also another great marketing idea for dentists.
Have a professional blog online. Share your experiences and interact with the readers. Also, share your professional experiences for the new professionals. Keep updating your readers with updated oral health tips and knowledge. Through blogs, you will not only be able to engage your patients with you but also be able to increase your authority within the field of dentistry. And never forget to share your blogs on your social channels.
Follow these marketing tips to attract more patients and you will most likely gain more patients in brief period of time.


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About the ovaries
The ovaries form part of the female reproductive system. The ovaries are oval-shaped and around four centimetres long (roughly the size of an almond). The two ovaries sit either side of the uterus, supported by ligaments and the blood supply which comes from the side of the pelvis. The fallopian tubes run along the side of the ovaries into the uterus.
Who has ovaries?
You may have ovaries if you are:
A woman who was assigned female at birth (recorded as female on her birth certificate).
A transgender man or non-binary person who was assigned female at birth.
An intersex person.
A man who has a difference in sex development (DSD).
If you have previously had surgery on your reproductive system, such as a hysterectomy (removal of the womb), you may have had your ovaries removed (oophorectomy).
If you are not sure whether you have ovaries, it is best to speak to your GP.
What do the ovaries do?
The ovaries have two main functions:
1. They produce ova (eggs)
During a process called ovulation, which occurs midway through a normal menstrual cycle, the ovaries release an egg, which can then be fertilised by sperm in order to create an embryo. If this embryo then implants into the lining of uterus (womb), it may grow into a foetus.
Usually, only one egg is released each menstrual cycle. Sometimes however, the ovaries can release two eggs in one menstrual cycle (this can lead to the birth of non-identical twins if both eggs are fertilised).
Ovaries contain all the eggs that they will ever have at birth. More eggs will not be produced during a lifetime.
Ovaries release an egg (ovulate) once a month from puberty (the period during which people reach sexual maturity, usually during their teenage years) to the menopause (the time during which a person stops menstruating, i.e. having a period).
Some types of contraception can stop the ovulation process from happening, in order to prevent pregnancy. You will also not ovulate if you are pregnant.
2. They produce female sex hormones oestrogen and progesterone
These two hormones play an important role in the menstrual cycle.
Oestrogen production will be higher in the first half of the menstrual cycle, before the egg is released. When oestrogen levels are high, this causes a surge in a luteinizing hormone, which triggers the release of the egg from the ovary.
Oestrogen also helps regulate cholesterol, keep your bones healthy and can affect skin and other tissues including the vagina. It helps with vaginal blood flow, lubrication and keeps vaginal tissue elastic.
Progesterone production will be higher in the second half of the menstrual cycle, after the egg has been released. Progesterone causes the lining of the uterus (womb) to thicken, ready for the egg to implant if it has been fertilised.
Oestrogen and progesterone levels fall after menopause.
Hormone replacement therapy (HRT) uses both these hormones, unless you have had a hysterectomy, when oestrogen only HRT is usually used.
Ovarian health
Ovarian cysts are very common before the menopause. You can find out more about ovarian cysts here.
Some people have a condition call Polycystic Ovary Syndrome (PCOS). Again this is very common; it is estimated that 1 in 10 women have PCOS. You can find out more about this here.
Ovarian cancer is an uncommon cancer, which affects 1 in 50 women according to Cancer Research UK. There are many different types of ovarian cancer. You can find out more about ovarian cancer and its symptoms here.
How Ovacome can help
If you have any questions about the ovaries, or are worried about symptoms that you are experiencing, please get in touch on our support line. You can call us on 0800 008 7054 or email [email protected] . You can also use the pink instant chat box at the bottom of your screen to ask us a question. We are open Monday to Friday, 10am to 5pm. A member of our team will be able to offer you personalised information and support.
If you are experiencing any unusual symptoms, which are persistent, please don't delay going to see your GP.
Last updated December 2021. Due for review December 2023.
Published: 8th January, 2009
Updated: 8th December, 2021

redpajama_set_name: RedPajamaCommonCrawl


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Looking back at 2015.
4 m consultation in Belgium:
Published on 12 December 2015 by Jean-Jacques ON7EQ
This to inform you that our national telecom authority (BIPT/IBPT) has launched on 4 December a public consulation regarding the possibility of expansion of our 4 m band (currenty 70.190 MHz- 70.4125 MHz) to 70,1125 MHz - 70,4125 MHz, all modes, and increase of power (25 W to 50 W), still on a secondary basis.
This in view of the fact that professional users are apparently no longer using this band segment.
As with previous similar public consultations, it can be expected that the band will be effectively be expanded within next weeks. A good thing - besides further widening the available segment for traffic - is that some planned beacon(s) could now be relocated as far as possible 'down the band' instead of somewhere in the upper segment.
Macedonia expands the 4 m allocation:
Published on 17 August 2015 by Dave EI3IO
I have received an email from the President of the IARU Member Society in Macedonia which states that the Macedonian administration (Agency for Electronnic Coommunication) has granted a request by the Radio Amateur Union of the Republic of Macedonia for further access to the 70 MHz band and has approved the following frequencies: 70.000 MHz, 70.075 MHz, 70.125 MHz an 70.275 MHz for Radio Amateur activities on a secondary basis .... date of issue 01.08.2015 and date of expiry 31.12.2016. It is not quite clear how wide these allocations are. However if we refer to the Macedonian National Plan on pages 136 - 138 you will find that the band comprises 12.5 kHz channels in accordance with CEPT Recommendation T/R 25-08.
Gibraltar issues CEPT on 4 m:
Published on 6 August 2015 by Jean-Jacques ON7EQ
I am pleased to announce that the Gibraltar Regulatory Authority (GRA) has from 5 August 2015 allowed operation on 70 MHz in ZB2 on a reciprocal basis (CEPT) and issued the first license as such to undersigned. Before, operation for visiting HAMS was only possible on 6 m and 2 m, but thanks to the efforts of the Gibraltar Amateur Radio Society (GARS), the bands have been extended to include 4 m and 70 cm. Still, the application for a temporary reciprocal license must be completed - see GRA website for more info.
IARU 70 MHz initiative:
Published on 29 July 2015 by Bo OZ2M
Dave Court, EI3IO, and Member of the IARU Region 1 Executive Committee has written a 70 MHz initiative sent to all the member societies and their respective laison officers. It addressed the latest situation concerning the 4 m band, 69,9 MHZ to 70,5 MHz.
Germany back on 4 m:
Published on 29 April 2015 by Bo OZ2M
As of 29 April 2015 German hams can use, on a secondaty basis, the 4 m band again until end of 31 August 2015. The conditions are: 70,150 MHz bis 70,180 MHz, max 25 W ERP, max bandwidth 12 kHz, all modes and horizontal antennas.
Spain gets permanent allocation:
Jose, EA7KW, writes: "The frequency band from 70.150 MHz to 70.200 MHz may be used by the amateur service on a secondary basis and the technical conditions set out in Annex I to Regulation use of public domain by amateurs , approved by Order IET / 1311/2013, 9 July." Furthermore is the allocation now permanent since 6 April 2015.
Ofcom permits up to 71,5 MHz:
Published on 3 April 2015 by Bo OZ2M
RSGB writes that Ofcom have agreed the use of 70.5 MHz to 71.5 MHz by radio amateurs for digital experimentation. Use will be permitted only via a Special Research Permit and further details of the application process will be published in due course.For information, the following conditions will apply:
Access to this part of the spectrum will be authorised under a Notice of Variation, time-limited to 12 months and available to Full Licence holders only.
Ofcom will retain the right to reallocate Amateur Radio spectrum at 70.5 – 71.5 MHz should there be a demand for this part of the spectrum from Business Radio and/or other or new services. In the event of this happening, Ofcom will not consult on this decision. However, Ofcom will provide Amateur Radio users with 12 months' notice before such reassignment and this notice period will be publicised on the Ofcom website.
Amateur Radio use of this spectrum will be permitted on a non-protection, non-interference basis. Please note that if use is shown to cause interference, the spectrum will be removed with immediate effect
Permission will be subject to a geographical restriction and only granted for use in England, Guernsey, Isle of Man, Jersey, Northern Ireland and Wales. (There is legacy use of the spectrum by the Scottish Government which precludes licensing for Amateur Radio)
Note that in a similar manner to 146-147 MHz, international coordination is likely to be required as use must be compliant with the level published in the Harmonised Calculation Method (HCM) Agreement of +6 dBuV/m.
Malta on 4 m:
Published on 16 February 2015 by Paul 9H1BT
The 70,0 MHz - 70,5 MHz band has been allocated to Amateur Radio use on secondary basis and included in the National Frequency Plan as published by the Mata Communications Authority (MCA) on 13 Feb 2015.
There are quite a few local stations interested in being active on 4 m.
Finland gets 300 kHz continuous allocation:
Published on 2 January 2015 by Bo OZ2M
Erik, OH2LAK, writes that the allocation in Finland now covers 70,0 MHz to 70,3 MHz continuously without any special permit but still as a secondary service.


JERUSALEM (AP) -- An Israeli college has conducted an opinion poll of attitudes inside Egypt and Saudi Arabia, finding virtually no support for presumptive Republican presidential nominee Donald Trump in the two Arab countries.
The survey, conducted by the Interdisciplinary Center Herzliya, could signal trouble for Trump if he wins the November election and sets out to devise a Mideast policy. Egypt and Saudi Arabia are two of America's most powerful and important allies in the Arab world.
When asked who their preferred candidate was, just 3.8 percent of Egyptian respondents chose Trump. In Saudi Arabia, only 6 percent favored Trump.
The presumptive Democratic nominee, Hillary Clinton, did better, though support was far from overwhelming. In Egypt, 35.7 percent of respondents chose Clinton, while in Saudi Arabia that number was 30.2 percent.
"The overall pattern is that most people ... do not support either candidate, but they hate Trump essentially and one out of three support Hillary," said survey director Alex Mintz, director of the IDC's Institute for Policy and Strategy.
Mintz said Trump's poor ratings were likely the result of his inflammatory comments toward Muslims. Following the attacks by Islamic extremists in Paris and San Bernardino, California, last year, Trump called for a temporary ban on Muslims entering the U.S. He has also spoken against accepting Syrian refugees.
Mintz said the large number of respondents who preferred neither candidate — 41 percent in Egypt and 50 percent in Saudi Arabia — signaled general unhappiness with both of them.
But the discontent with the U.S. runs deeper than the presidential candidates. Just 16.7 percent of respondents in Egypt described President Barack Obama as being good or very good for the Muslim world. In Saudi Arabia, that figure was 20.1 percent.
The survey interviewed 471 respondents in Egypt, with a margin of error of 4.5 percentage points, and 464 people in Saudi Arabia, with a 4.6 point margin of error, over a six-week period.
In a novel approach, it was carried out by telephone by Arabic speakers who said they were calling from the Institute for Policy and Strategy. If pressed, they told respondents that they were located in Israel.
"We are not hiding anything," said Eli Mograbi, who helped run the survey. Israel has a peace agreement with Egypt, but no formal relations with Saudi Arabia.
The survey was released Friday ahead of the IDC's Herzliya Conference, an annual gathering of active and retired officials from around the world set to take place next week. Former Secretary of State Henry Kissinger as well as top Israeli politicians and security officials are scheduled to deliver addresses.


An allergy is a reaction your body has to an allergen such as pollen, dust, pet dander, mold or foods.
Your immune system is designed to protect you from foreign invaders, or germs, but sometimes it overreacts to relatively harmless substances. This is known as an allergic reaction. Some of these substances include pollens, molds, dust, animal dander, medications and foods. When a person's body is exposed to a certain response controlled by a chemical called IgE, it will lead to the typical symptoms of itchy eyes, sneezing, stuffy nose and wheezing.
Dangerous allergic reactions that affect the whole body – called anaphylaxis – can cause severe wheezing/shortness of breath, throat swelling, cardiovascular collapse, hives, swelling or death.
Asthma, too, is caused by this problem (IgE mediated allergic response) affecting the lungs.
Allergy testing at Gainesville Allergy Center by Accent is performed using a combination of skin pricks. Adults and children of any age can be tested for allergies. Allergy testing can be done as skin tests or as blood tests. Usually, allergy tests are done under the guidance of an allergy specialist. These specialists are trained in the best methods for testing and treating allergies.
During the allergy skin test, a drop of a suspected allergen is pricked or scratched on the surface of the skin. The test is performed on the back or forearm. Many suspected allergens are tested at the same time. If you are allergic to one of the tests, you will have redness and swelling at the test spot. There is minimal discomfort to the patient. Test results are available when session is completed.


text:
Le Tombeau de Bibi Jawindi est l'un des cinq monuments à Uch Sharif dans le Pendjab au Pakistan, qui sont sur la liste indicative des sites du patrimoine mondial de l'UNESCO. Datant du , le sanctuaire a été construit en 1493 par un prince iranien, Dilshad, pour Bibi Jawindi, qui était l'arrière-petite-fille de Jahaniyan Jahangasht, un célèbre saint soufi.

Situation
Le site est situé dans le coin sud-ouest d'Uch, une cité ancienne fondée par Alexandre le Grand, dans l'état du Bahawalpur à l'intérieur de la province du Pendjab. Uch, appelé localement Uch Sharif, est connue comme le foyer de la "culture des sanctuaires" en raison de son importance culturelle et de la présence de plusieurs monuments et sanctuaires.

Architecture
Considéré comme l'un des monuments les plus décorés à Uch, le tombeau de Bibi Jawindi est un site majeur pour les visiteurs. L'extérieur de l'édifice est de forme octogonale et dispose de trois niveaux dont le plus haut soutient un dôme, tandis que l'intérieur est circulaire à cause de l'épaisseur des murs inclinés supportant deux étages. À la fois l'intérieur et l'extérieur du bâtiment sont richement décorés avec des écritures islamiques, du bois sculpté, et des carreaux de mosaïque d'un bleu vif et blanc appelé faïence. Le niveau de base est soutenue par huit tours effilées dans chaque coin. L'enceinte renfermant le tombeau est conservé dans sa condition désertique d'origine et est essentiellement couverte avec des tombes cimentés. La zone environnante est couverte de végétation en raison d'un réseau d'affluents du fleuve et des canaux qui traversent la zone.

Site du patrimoine mondial
Le site a été proposé par le Département d'Archéologie et des Musées du Pakistan en  pour être admis dans les Sites du Patrimoine Mondial, ainsi que quatre autres monuments de la région. Ces monuments sont le Tombeau de Baha al-Halim, la Tombe d'Ustead (l'architecte), Tombeau de Jalaluddin Bukhari, et la Mosquée de Jalaluddin Boukhari. Le site a été soumis en vertu des critères ii, iv et vi dans la catégorie culturelle. En 2012, il est toujours sur la liste indicative.

Conservation

Au fil des siècles, le tombeau s'est désagrégé gravement en raison des conditions environnementales, et lors des crues torrentielles en 1817, la moitié de la structure a été emporté. La moitié seulement de la structure est resté jusqu'à aujourd'hui. En 1999, le Centre de Conservation et de Réhabilitation du Pakistan a invité les organismes internationaux et les fonctionnaires de la ville pour travailler sur la conservation du site. Toutefois, en raison de l'humidité, de l'infiltration du sel, et de l'érosion le groupe de monuments est encore en train de s'écrouler. Des méthodes inappropriées de réparation ont affaibli le bâti. Le World Monuments Fund a placé la structure sur leur liste de Surveillance, en 1998, 2000 et 2002 afin de recueillir l'attention internationale et obtenu des subventions pour la conservation des tombeaux.

Galerie

Voir aussi
 Liste du patrimoine mondial au Pakistan

Références

Site archéologique au Pakistan
Liste indicative du patrimoine mondial au Pakistan


I read the word lethal in a poem, it leapt from the page and I had to stop a moment to consider the impact of the word; for us as humans, for a hospice nurse who watches people in their last hours and days.
Just like when you buy a new car and everyone seems to have one the same make and model, I heard the word lethal thrown around casually almost daily in a week's time.
Naturally, this made me curious as to the origins of the word lethal. So I researched the word, and found that lethal in Latin: "letalis"tanslates equivalent to death (in Greek: lethe, oblivion) the word meaning of or causing death; deadly; fatal.
And I thought of the human condition, a lethal one.
"What will I do with my one wild and precious life?"….
This entry was posted in living and tagged attitude, live, personal choice. Bookmark the permalink.


The 68th annual Kiwanis Pancake Days are coming March 1-2, 2019, to the Red River Valley Fairgrounds.
Serving more than 11,000 people and 20,000 pancakes in 2018, the group expects just as many, if not more, this year.
Bill Mabry, president of the Kiwanis Club, said anyone wanting tickets can contact any Kiwanis member, or call 903-214-2218.
Tickets are $6 in advance and $7 at the door and children 5 and under are free.


text:
namespace SuperMassive.Fakers.Tests.Units
{
    using NUnit.Framework;

    public class ColorTest
    {
        [Test]
        public void ColorAsIntegerTest()
        {
            for (int i = 0; i < 500; i++)
            {
                int result = Fakers.Color.ColorAsInteger();
                System.Drawing.Color color = System.Drawing.Color.FromArgb(result);
                Assert.False(color.IsEmpty);
            }
        }
    }
}

redpajama_set_name: RedPajamaGithub


SAN JOSE, Calif., Sept. 28, 2018 /PRNewswire/ -- YuJa Inc. formally announces a new partnership with Weber State University, a public university in Ogden, UT, to support faculty and students in creating, streaming and collaborating with video within the Canvas Learning Management System.
Following a competitive RFP process, Weber State University selected YuJa to provide tools for "creating and sharing video-based assignments and interviews with video time-stamped commenting and full Canvas integration." Additionally, YuJa is used for capturing, storing, and streaming media both within Weber State's local Intranet and publicly.
The YuJa Enterprise Video Platform is a leading higher-education video solution that integrates with the university's existing Canvas Learning Management System (LMS) and identity provider infrastructure to support the university's novel educational workflows including real-time video commenting and asynchronous social learning. "Our partnership with Weber State is an affirmation of both the breadth and depth of our video platform's asynchronous and synchronous video collaboration capabilities," said Dr. Ajit Singh, President of YuJa Inc.
YuJa is a leader in enterprise video solutions. Our products harness the power of video to educate, engage, inspire and collaborate. We serve organizations of all sizes within all sectors, including higher-ed, K-12, government and corporate, delivering video experiences including lecture capture, live streaming, media management, video conferencing, and immersive social & mobile engagement tools. We have legal headquarters in Delaware with primary U.S. offices in Silicon Valley, California and Canadian offices in both Waterloo and Toronto.
Weber State University is a public university in Ogden, Utah that prides itself in its quality teaching, its commitment to meeting the needs of students at every stage of life and its ongoing service to the community. WSU serves over 26,000 students and offers more than 200 certificate and degree programs—the largest and most comprehensive undergraduate offering in the state. The university also offers 13 graduate degrees.


In this class we will focus on the technique behind our jumps and turns. We will discuss strategies behind multiple turns and higher jumps, while still executing the technique correctly. Levels 2, Intermediate, and Advanced welcome. The class will move at a fast pace and each level will be given different combinations to focus on.


I tried the key from another box, activated right away. Facepalm. I tried the key several times, triple-checked for typos, so it wasn't a typo. We actually got a misprinted key, or perhaps it was not allowed to activate, and now today if I try again it'll work. Ugh.
The following is being left for posterity.
Our new Dell rep, poor guy, he unhappily told me today that what they (old team) sold us initially would actually never work (OEM licensing + VMware). Rather unfortunate. Well, at least it explains why I had so many issues getting an answer from support. They had to go to a senior senior tech rep to get this cleared up.
After a few years now of running a fair-size home VMware lab - my thoughts.
EDIT update2: See newer post, it wasn't working because the key was misprinted (apparently very rare, but does happen). We used another OEM 2012R2 key and it worked.
The below is what happens when nobody realizes this is the case.
Posting about this because Google failed me, and 75% of the reps I spoke to (3/4) had zero clue how to resolve the problem.
Problem: You are running ESXi. Your server has 2012R2 Datacenter (or whatever) OEM licensing that allows unlimited VOSE's. You make an ISO of the provided & corresponding OEM media and install to create a fresh template. The server's key (on the sticker) does not let you activate said guest VM.
Solution: You should have received the downgrade package 'DO NOT DISCARD' with one or two stickers containing Microsoft license keys - the title post-fixed with PHYS, one with VIRT. If you did not, request it from your Dell rep.
I've recently noticed my mouse charge levels starting to drop, and this has re-awakened the urge to upgrade.
But I shant! They shall be run to destruction this time around the consumer wheel...getting pretty good mileage out of them so far!


text:
Posts Tagged 'Carl D. Perkins Act'
114th Congressional Wrap-Up and Perkins Outlook
Following the November elections, lawmakers have been on Capitol Hill for the final phase of the 114th Congress. This lame duck session was formally scheduled to come to an end this upcoming Friday, but the last-minute passage of a continuing resolution (CR) last week allowed lawmakers to adjourn the 114th Congress a week early after the bill cleared the Senate.
With policymakers digesting the results of the elections and planning ahead for 2017, there were not too many education or workforce-related highlights from this final session of Congress to speak of. The dearth of legislative activity did make room for the composition of the respective House (HEW) and Senate (HELP) education committees to become clearer.
In the Senate, Chairman Lamar Alexander (R-TN) will retain his leadership role of the HELP Committee. Ranking Member Patty Murray (D-WA) will also keep her slot going into next year. This year this duo, along with Senators Enzi (R-WY) and Casey (D-PA), came close to passing a comprehensive reauthorization of the Carl D. Perkins Act, but unfortunately these efforts stalled as the year wore on. The root cause of this delay were continued disagreements related to the oversight authority of the U.S. Department of Education (USDE).
With the retirement of Chairman John Kline (R-MN), the House education committee recently named a new Chairwoman—Rep. Virginia Foxx (R-NC)— to lead HEW in the 115th Congress. Rep. Foxx recently won her seventh term in Congress, and has been the Chairwoman for HEW's subcommittee on higher education since 2010. Prior to her tenure in Congress, she was a professor and administrator at several postsecondary institutions in North Carolina. On the Democratic side of the aisle Ranking Member Bobby Scott (D-VA) will retain his leadership position on the committee.
Earlier this year the full House overwhelmingly passed H.R. 5587—comprehensive legislation that would reauthorize the Perkins Act. While there were some remaining items that needed to be addressed as the bill made its way over to the Senate (primarily a fix for the proposed definition for a secondary CTE concentrator), Advance CTE endorsed and supported this legislation's passage. Unfortunately due to the reasons cited above, the bill lost momentum when it arrived in the Senate.
As we look ahead to the next Congress, lawmakers in both chambers have expressed interest in taking up Perkins reauthorization. However, a specific timeline for the law's consideration is still unclear and it will be competing with other education priorities such as a renewal of the Higher Education Act (HEA). In the coming year, Advance CTE will continue to advocate for a thoughtful reauthorization process for Perkins in this new environment and will urge lawmakers to build upon the strong foundation laid with H.R. 5587 to support high-quality CTE for years to come.
Be sure to check back here for an in-depth look at what else is in store in the 115th Congress in coming week.
Tags: 114th Congress, 115TH Congress, Carl D. Perkins Act, Carl D. Perkins Act reauthorization, HR 5587, Perkins, Reauthorization
Congress Averts Government Shutdown with Stopgap Funding Legislation
On Friday the House and Senate successfully passed a second "continuing resolution" (CR)— short-term stopgap funding legislation that temporarily extends current Federal Fiscal Year (FY) 2016 spending levels through April 28th, 2017. The legislation provides funding for the federal government until this date or until a separate full-year appropriations bill is enacted into law. The current 2016 fiscal year began this past October and the federal government has been operating under the auspices of an earlier CR passed by Congress just before this deadline.
While it had seemed likely that Congress would pass comprehensive spending legislation for the full fiscal year during the current lame duck session of Congress, as they have several times in years past, incoming President-Elect Donald Trump requested that these critical funding decisions be further delayed until next spring.
This decision leaves the outlook for funding for important federal programs, like the Carl D. Perkins Act, uncertain in the interim. This year's earlier CR required a 0.496 percent across-the-board cut to all discretionary federal programs, including the Perkins Act's basic state grant program. Due to the Budget Control Act's (BCA) sequester caps, which significantly restrict the amount of funding available for programs like Perkins each year through the next decade, this reduction translated into $5.5 million in fewer funding for Perkins, students, and the CTE programs the law supports.
At that time, the U.S. Department of Education (USDE) revised states' Perkins allocations in October and 30 states received reduced grants amounts due to the passage of this temporary legislation.
This most recent CR re-adjusts this half percent reduction somewhat to 0.19 percent to stay within the BCA caps. However, USDE is not likely to reimburse states for the difference between these two spending cuts until a full-year spending bill is successfully enacted.
The ongoing uncertainty caused by the current series of stopgap funding measures from Congress is already creating uncertainty for states and local school districts who need to prepare budgets for the upcoming academic year. Moreover, the budget process for the next federal fiscal year (2018) will begin in late winter of 2017 further complicating matters as efforts to fund federal programs like Perkins increasingly overlap.
Advance CTE encourages the CTE community to let their members of Congress know how important it is to restore cuts to Perkins in the coming months and pass comprehensive legislation that replaces these counterproductive CRs moving forward. To do so click here. Be sure to check back as the outlook for Perkins funding continues to evolve.
Tags: Carl D. Perkins Act, Carl D. Perkins Act Funding, Continuing Resolution, FY 2016 Funding, FY 2017 funding, perkins funding, USDE
Election 2016: From Governor's Mansions to the Senate, the Democratic Ticket Boasts Years of CTE Experience
This is the second part of a series exploring the 2016 presidential candidates' positions, records and statements about Career Technical Education (CTE). This post examines the Democratic ticket. A previous post covering the Republican ticket is accessible here.
An Advocate for Children and Families, Clinton Sees Opportunity in Free College
With decades in the public eye, Democratic Nominee Hillary Clinton has had ample opportunity to define and hone her position on education, which she says "should be the great door-opener." Her campaign aims to knock down barriers to the middle class through apprenticeships, career technical education (CTE) and debt-free college.
Clinton's work in public education dates back to 1983 when, in her role as First Lady of Arkansas, she led an initiative to develop more rigorous standards for public schools in the state. Years later, as New York's junior Senator, she went on to serve on the Senate Health, Education, Labor and Pensions (HELP) Committee. There, she worked on two foundational pieces of education legislation: the No Child Left Behind Act and the Carl D. Perkins Career and Technical Education Act (Perkins).
Clinton's education policy platform for the 2016 election aims to expand access to the middle class by removing barriers to higher education. She has proposed a plan to make community colleges free and to cover the cost of tuition at in-state four-year public colleges and universities for families making less than $125,000. These proposals are loosely based on similar efforts in Tennessee and other states that have seen increased enrollment and higher retention rates at community and technical colleges.
As crucial as college is, Clinton asserted in her Democratic National Convention speech in July that, "a four-year degree should not be the only path to a good job." She went on to say "we're going to help more people learn a skill or practice a trade and make a good living doing it." To do this, her campaign has proposed a tax credit of up to $1,500 for businesses hosting apprentices and is considering "options to incentivize CTE programs and help provide grants to train workers for the 21st century economy."
Tim Kaine's Support for CTE Dates Back to His Work as a Teacher in Honduras
Perhaps the the lengthiest CTE résumé this cycle goes to Democratic Vice Presidential Candidate Tim Kaine. His education record — which includes broad initiatives as Virginia Governor and tireless support for CTE in the Senate — dates all the way back to his childhood.
The son of a welder, Kaine briefly helped manage a technical school in Honduras before returning to complete his law degree at Harvard University. Kaine's interest in CTE followed him to the Virginia Governor's mansion where, in 2008, he announced an initiative to create six Career and Technical Academies across the state. The initiative, which was launched with a grant from the National Governor's Association, aimed to align K-12 instruction in STEM fields with workforce and postsecondary expectations, while equipping more students with marketable skills that lead to high-demand, high-wage careers.
In Virginia, Kaine also launched the Governor's CTE Exemplary Standards Awards Program, which recognizes CTE programs that align with industry standards, effectively engage local partners, provide relevant and integrated academic and technical instruction, and more.
In the Senate, Kaine co-founded the bipartisan CTE Caucus along with Senator Rob Portman (R-OH) in 2014, stating that "career and technical programs … can strengthen the links between the classroom and the workplace, helping students acquire the education and skills that will help them find employment and enjoy productive, successful lives after graduation." His work with this caucus has led to the introduction of a number of CTE-related legislation, including the Educating Tomorrow's Workforce Act, which would establish a formal definition for CTE programs of study within the Perkins Act.
His persistent advocacy for high-quality CTE in the Senate led to a number of legislative victories, most recently in the Every Student Succeeds Act of 2015 (ESSA). With Kaine's support, ESSA now includes provisions to fund career counseling programs, help teachers integrate academic and technical instruction, add CTE to the definition of a "well-rounded education," encourage states to use career readiness indicators in their accountability systems, and fund professional development for CTE teachers.
CTE has long benefited from bipartisan support, and the 2016 election is no exception. With mere months until the election, we look forward to the candidates continuing to elevate high-quality CTE as an effective educational strategy in their platforms, in their speeches and in the debates later this fall.
By Austin Estes in News, Uncategorized
Tags: Arkansas, Career Technical Education, Carl D. Perkins Act, cte, CTE Caucus, CTE Exemplary Standards Awards Program, Education Platform, Election 2016, ESSA, Free College Tuition, Governor's Career and Technical Academies, Hillary Clinton, New York, No Child Left Behind, Tim Kaine, Virginia
National CTE Organizations Weigh In on House Perkins Reauthorization Efforts
The Association for Career and Technical Education (ACTE) and Advance CTE today commended the House Education and the Workforce Committee's release of the "Strengthening Career and Technical Education for the 21st Century Act," a bipartisan bill to reauthorize the Carl D. Perkins Career and Technical Education Act.
"We applaud our partners in Congress for their work to begin the Perkins reauthorization process in releasing this bill, as well as the spirit of bipartisanship that has made that work possible," said ACTE Executive Director LeAnn Wilson. "We can now turn our attentions to carefully examining the legislative language to ensure that the priorities of CTE students and professionals will be supported throughout the new law. We look forward to continuing to work with committee leaders as the reauthorization process unfolds, as America's students, workforce and economy deserve nothing less than a thoughtful new bill."
"We are encouraged by this important step towards reauthorizing Perkins," said Kimberly Green, Advance CTE Executive Director. "Helping all learners successfully navigate pathways to post secondary education and careers is a national priority shared by state leaders, educators, employers and Congress and Perkins has a critical role in achieving this goal. We appreciate the bipartisan efforts that went into drafting this bill and look forward to working to ensure the reauthorized bill helps increase access to and success in high-quality CTE programs."
Both organizations remain committed to working with the House Education and the Workforce Committee, as well as their partners in the U.S. Senate, to find a path forward for Perkins.
Katie Fitzgerald, Communications AssociateÂ
By Katie Fitzgerald in Advance CTE Announcements
Tags: Carl D. Perkins Act, Perkins


Timеѕ hаvе changed аnd social mеdiа iѕ nоw a necessity fоr аnу business tо strive. Thеrе аrе mаnу things уоu саn dо with social mеdiа аnd if dоnе correctly, уоu аrе аblе tо increase productivity, improve sales аnd reaching оut tо mоrе customers.
In short, social mеdiа iѕ extremely important fоr уоur business.
If уоu аrе ѕtill nоt convinced, thiѕ article iѕ fоr you.
Business iѕ аll аbоut thе customers аnd trуing tо figure оut whаt thеir preferences аrе соuld tаkе a lоng timе (and nоt tо forget, a lot оf money аѕ well). But with social media, уоur job iѕ cut short bу miles. Traditionally, уоu will perform vаriоuѕ market research tо uncover thе gems in thе market аnd еасh оf thеѕе market research соuld tаkе months tо complete.
Thаnkѕ tо technology аnd thе emergence оf social media, market research саn bе completed faster аnd mоrе accurate. Fоr example, wе hаvе Facebook Insights аnd Twitter Analytics. Bоth оf thеѕе tools аllоw уоu tо gather mоrе data frоm a large number оf audience.
Targeting a billion (or more) potential customers iѕ a challenging task. Hоwеvеr with social media, targeting аnd retargeting аrе made easier. Tools likе Hootsuite аllоwѕ уоu tо target audience based оn location аnd interests. With thе right targeting, уоu аrе аblе tо reach mоrе relevant audience with lеѕѕ budget needed.
Social mеdiа platforms ѕuсh аѕ Facebook аnd Twitter аllоwѕ уоu find nеw customers. Here's hоw it iѕ done.
Yоu send thеm a message аnd inviting thеm tо trу оut уоur nеw cafe in town with a ѕресiаl discount offer.
Thеrе аrе mаnу wауѕ уоu саn find nеw customers uѕing social mеdiа аnd whеn it соmеѕ tо social media, thе sky iѕ thе оnlу limit.
Customers аrе uѕing social mеdiа аѕ a tool tо communicate with brands. Tаkе a lооk аt GoDaddy fоr example. Thеу created @GoDaddyHelp оn Twitter аѕ a platform tо communicate with customers whо require immеdiаtе assistance. Whеn brands аnd companies (such аѕ yours) communicates with customers directly оn social, it shows thаt уоu care fоr thеm аnd thiѕ wоuld improve thе business relationship bеtwееn bоth parties.
Plus, dо nоt forget thаt social mеdiа iѕ a great wау tо listen tо уоur customer's complains. Whеn it соmеѕ tо problem solving, quick resolution wоuld lead tо happier customers аnd it will аlѕо improve thе retention vаluе fоr thе company.
Publishing updates оn social mеdiа iѕ nоt оnlу good tо build аn audience but аѕ wеll аѕ increase visibility оn search engines. Whеn уоu rank bеttеr оn search engines, уоu will gеt mоrе visibility аnd indirectly, mоrе traffic back tо уоur website.
Yоu dо nоt nееd tо pay subscription fees fоr thе platform аnd thеrе iѕ nо registration cost.
Fоr businesses, thiѕ iѕ extremely important аѕ it will hеlр a lot еѕресiаllу whеn it соmеѕ tо thоѕе with shoestring budgets. If уоu аrе required tо invest in social mеdiа marketing (paid advertisements), уоu аrе аblе tо adjust аnd set thе budget thаt fits уоur need. On top оf that, уоu саn easily gauge thе expected marketing cost tо ensure thаt уоu dо nоt exceed уоur givеn budget.
At thе ѕаmе time, paying fоr social mеdiа advertising iѕ оftеn considered muсh cheaper compared tо native advertisements ѕuсh аѕ advertising оn newspaper, magazines аnd radio.
If uѕеd properly, social mеdiа саn hеlр уоur business reach уоur goals.
Social Mеdiа platforms ѕuсh аѕ Facebook, Twitter аnd Instagram аrе аll staples nоw fоr bоth established аnd growing businesses. Thе оbviоuѕ rеаѕоn оf соurѕе iѕ thаt thеѕе pages саn givе brands thе leverage it nееdѕ in terms оf exposure – аnd аt a vеrу lоw cost аt that!
Social Media's wide coverage аnd cost-efficiency iѕ perfect fоr nеw businesses thаt dо nоt hаvе a big marketing budget yet. However, mоѕt entrepreneurs wоuld find thаt marketing a business оn Social Mеdiа iѕ nоt аѕ easy аѕ it seems. Competition fоr attention in thеѕе platforms аrе stiff, аnd аlmоѕt еvеrу business (no matter hоw small аnd big) аrе vying fоr customers.
Althоugh thiѕ dоеѕ nоt directly translate tо sales, gaining insights frоm уоur target market саn hеlр уоu craft mоrе effective messages аnd deals thаt саn work fоr future promotions.
Yоu саn dо thiѕ bу tracking whiсh оf уоur posts hаd bееn mоѕt likеd оr mоѕt commented upon, аnd уоu саn аlѕо check оut уоur followers' demographics tо ѕее in whiсh age range dо mоѕt оf thеm belong, thеir gender, аnd роѕѕiblе locations.
Thiѕ iѕ рrоbаblу thе mоѕt unique advantage thаt Social Mеdiа саn afford аnу business (or anyone) fоr thаt matter – real-time feedback. Unlikе television оr radio advertising, уоu hаvе nо wау оf knowing аѕ tо whаt уоur audience thinks, but with Social Media, уоu саn directly receive thеir concerns аnd inquiries аnd attend tо thеm right away.
Furthermore, уоu nееd аll thе feedback уоu соuld gеt ѕо уоu саn improve uроn it whilе you're ѕtill in thе еаrlу ages оf уоur business.
Social Mеdiа iѕ great fоr exposure, thаt iѕ unquestionable. However, it's nоt еnоugh tо establish a good customer relationship bесаuѕе оf itѕ impersonal, one-post-fits-all nature.
Yоu саn hоwеvеr attract уоur followers tо sign uр tо уоur email newsletter thrоugh Social Mеdiа ѕо уоu саn start a mоrе engaging journey with them. Yоu саn аlѕо offer a freebie thаt оnlу requires thеir membership tо уоur blog – еithеr way, thе point is, it саn hеlр уоu tоwаrdѕ mоrе fruitful marketing strategies if dоnе right.
A legitimate аnd well-maintained (constantly updated) Social Mеdiа page саn boost уоur company's standing in Search Engines ѕuсh аѕ Google. It аlѕо givеѕ a good impression tоwаrdѕ customers еѕресiаllу if уоu constantly update posts аnd answer tо comments аnd queries. Thiѕ means thаt уоur company iѕ transparent аnd "safe," аnd nоt a potential online scam оr a business with a vеrу bad reputation nо оnе knоwѕ about.
People wаnt tо research thе brands аnd businesses thеу support, bе ѕurе уоu саn bе found!
Social Mеdiа marketing iѕ rеlаtivеlу cheaper. Aѕidе frоm that, уоu аlѕо gеt tо save mоrе timе аѕ it саn verily "promote" itself. Onсе уоu post аn update, уоu саn leave it thеrе fоr hours аnd соmе back tо check fоr роѕѕiblе engagements whеn уоur timе permits.
In thаt sense, Social Mеdiа iѕ easily manageable аѕ a campaign, рluѕ уоu саn answer queries аnd feedbacks thrоugh уоur mobile device already.
It might bе ѕаid thаt promoting уоur business thrоugh Social Mеdiа iѕ likе jumping intо thе bandwagon, but it iѕ nесеѕѕаrу in order fоr уоu tо gаin leverage. Aftеr all, whаt уоu nееd аrе mоrе customers ѕо уоu саn expand уоur business.


Glowing, luminous skin is the key to looking healthy and refreshed. So when you have a flare-up—be it acne, rosacea or ezcema—it can really get in the way of you and your best self. Since these battles are real (and not easily solved with any one miracle product), we enlisted skin-care guru Kate Somerville. Here, her dietary and at-home remedies for treating problem skin for good.


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Bachelor of Arts degree in Youth and Family Ministry with a minor in Psychology from MidAmerica Nazarene University.
Licensed as a Marriage and Family Therapist and a Professional Counselor.
Ryan established his personal relationship with Jesus Christ in 1997, has been married since 2005, and is the father of 2 boys and 2 girls. His faith, marriage and family are the three most rewarding and fulfilling aspects of his life. As a result, he is passionate about helping others develop and maintain their own faith in God. He strives to help couples build and maintain meaningful marriages and guide spouses in discovering ways to stay positively connected with each other through the stresses of every day life. Ryan is also passionate about helping parents find support, encouragement and guidance as they navigate their parenting experiences with their children from infancy to adulthood.
Prior to joining CFCC, Ryan spent 4 years working in the field of Child Welfare as a case manager and as a family therapist to families seeking support with parenting education and child behavior management. He specializes in using a strengths based approach to guide others in how they can best use their own strengths to address presenting problems. Ryan works with individuals, couples and families and strives to build a warm, inviting, compassionate, and faith filled therapeutic experience.


Image Title: Amazon Com Tri Fold Hardwood Futon Frame Twin Size Kitchen Dining Inside Wood Ideas 4. Filename: amazon-com-tri-fold-hardwood-futon-frame-twin-size-kitchen-dining-inside-wood-ideas-4.jpg. Image Dimension: 1000 x 667 pixels. Images Format: jpg/jpeg. Publisher/Author: Stan Kling. Uploaded Date: Wednesday - May 09th. 2018 21:05:13 PM. Category: Architecture. Image Source: dornob.com.
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Get the latest updates from Gymtech and the fitness industry here.
Gymtech is launching the newest update of Gymtech Music-TV, which include a brand new and improved version of the calendar-module.
We are proud to announce our new cooperation with ArrivalGuides.
We guarantee new and amazing content!


To support the recent proposed changes to the New Plymouth District Council's Long Term Plan we launched a multi-purpose web app called MyRates. The purpose of the app was to explore the relationship between the proposed changes and the user's rates bill.
MyRates gets personal by encouraging the user to enter their address and to provide opinions on each proposal. It displays the proposals' impact on the rates for that address and there is also an option to submit opinions to the council. Engagement through the app was huge and MyRates was a finalist in the 2015 ALGIM Web & Digital Project of the Year Award.
The consultation period on the proposed changes is now over and so some of the app's features have been stripped back to offer a new, quick and easy way for the New Plymouth public to access their rates information - greatly reducing the number of calls made to the council's support team to request rates figures.


Anyways... Where are we going? I realize neglected to include that in my last post... guess I was just processing leaving!
We will be heading to Georgia Southern University in Statesburo, Georgia... Contain your excitement please:)! Andrew has accepted an internship at the BCM there... Yes, that means this is another state of temporary. We will be there until May 2014... Then who knows!
As for our time there, it will be different. I have never really been a small town girl... And honestly I thought New Orleans felt small compared to growing up in Atlanta! You know a place is small when you ask what there is to do there and they list other cities you could travel to that are close by.
It will be harder to commit to as well, only being there less than a year. We will invest, get involved, and chances are, be uprooted again. But I am reminded that God wants us to be where we are... There is a reason for this season, no matter how short it is. We are committed to our calling there and will be "all in" in Statesburo!
Congratulations! They will love you guys!
Plus you'll have that sweet girl to keep you busy!
You will live in a reasonable travel distance!!!! I can't wait to meet Bailey Drew!


By 2040, approximately 11,920 renter households in Charlottesville and Albemarle County's urban areas will be paying more than 30 percent of their income for housing costs, according to preliminary numbers from a regional housing needs assessment.
The Thomas Jefferson Planning District Commission presented the 2040 Rural Long Range Transportation Plan to the Board of Supervisors at its regular meeting June 26. This is an update to the 2035 plan. The plan incorporates the TJPDC member counties of Greene, Albemarle, Nelson, Louisa and Fluvanna and the city of Charlottesville.


Bill Fletcher will also speak tomorrow night at Quail Ridge Books in Raleigh. Join him for a discussion about his book, Solidarity Divided: The Crisis in Organized Labor and a New Path Toward Social Justice.
Bill Fletcher is Director of the Field Services and Education Department of AFGE. He's also one of the leading activists and writers today on labor and race in the United States.
The Department of History at North Carolina State University is sponsoring a talk by Bill Fletcher on Thursday, October 29, 2009 at 3:00 pm in Withers Hall room #331. The event is free and open to the public.
Fletcher is the co-author of the book Solidarity Divided: The Crisis in Organized Labor and a New Path Toward Social Justice.
Fletcher was formerly the vice president for International Trade Union Development Programs for the George Meany Center of the AFL-CIO. Prior to his work at the George Meany Center, Fletcher served as AFL-CIO Education Director and later as Assistant to the President of the AFL-CIO.
Fletcher got his start in the labor movement as a rank-and-file member of the Industrial Union of Marine and Shipbuilding Workers of America. Combining labor and community work, he was also involved in ongoing efforts to desegregate the Boston building trades. He later served in leadership and staff positions in United Auto Workers District 65, the National Postal Mail Handlers Union, and the Service Employees International Union (SEIU).


text:
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) preserves gut barrier function by blocking neutrophil-endothelial cell adhesion after hemorrhagic shock and resuscitation in mice
Hong Yi Zhang, Iyore James, Chun-liang Chen, Gail E. Besner
Background: We have shown that heparin-binding epidermal growth factor-like growth factor (HB-EGF) protects the intestines from injury in several different animal models, including hemorrhagic shock and resuscitation (HS/R). The current study was designed to explore the mechanisms underlying the anti-inflammatory role of HB-EGF in preservation of gut barrier function after injury. Methods: In vivo, HS/R was induced in wild-type and neutropenic mice, with or without administration of HB-EGF, and intestinal permeability determined by use of the everted gut sac method. In vitro, cultured human umbilical vein endothelial cells (HUVECs) and freshly isolated human peripheral blood mononuclear cells (PMNs) were used to determine the effects of HB-EGF on HUVEC-PMN adhesion, reactive oxygen species production in PMN, adhesion molecule expression in HUVEC and PMN, and the signaling pathways involved. Results: We found that administration of HB-EGF to healthy mice led to preservation of gut barrier function after HS/R. Likewise, induction of neutropenia in mice also led to preservation of gut barrier function after HS/R. Administration of HB-EGF to neutropenic mice did not lead to further improvement in gut barrier function. In vitro studies showed that HB-EGF decreased neutrophil-endothelial cell (PMN-EC) adherence by down-regulating adhesion molecule expression in EC via the phosphoinositide 3-kinase-Akt pathway, and by inhibiting adhesion molecule surface mobilization and reactive oxygen species production in PMN. Conclusion: These results indicate that HB-EGF preserves gut barrier function by inhibiting PMN and EC activation, thereby blocking PMN-EC adherence after HS/R in mice, and support the future use of HB-EGF in disease states manifested by hypoperfusion injury.
https://doi.org/10.1016/j.surg.2011.10.001
Epidermal Growth Factor
Intercellular Signaling Peptides and Proteins
Endothelial Cells
Human Umbilical Vein Endothelial Cells
1-Phosphatidylinositol 4-Kinase
Zhang, H. Y., James, I., Chen, C., & Besner, G. E. (2012). Heparin-binding epidermal growth factor-like growth factor (HB-EGF) preserves gut barrier function by blocking neutrophil-endothelial cell adhesion after hemorrhagic shock and resuscitation in mice. Surgery, 151(4), 594-605. https://doi.org/10.1016/j.surg.2011.10.001
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) preserves gut barrier function by blocking neutrophil-endothelial cell adhesion after hemorrhagic shock and resuscitation in mice. / Zhang, Hong Yi; James, Iyore; Chen, Chun-liang; Besner, Gail E.
In: Surgery, Vol. 151, No. 4, 04.2012, p. 594-605.
Zhang, HY, James, I, Chen, C & Besner, GE 2012, 'Heparin-binding epidermal growth factor-like growth factor (HB-EGF) preserves gut barrier function by blocking neutrophil-endothelial cell adhesion after hemorrhagic shock and resuscitation in mice', Surgery, vol. 151, no. 4, pp. 594-605. https://doi.org/10.1016/j.surg.2011.10.001
Zhang HY, James I, Chen C, Besner GE. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) preserves gut barrier function by blocking neutrophil-endothelial cell adhesion after hemorrhagic shock and resuscitation in mice. Surgery. 2012 Apr;151(4):594-605. https://doi.org/10.1016/j.surg.2011.10.001
Zhang, Hong Yi ; James, Iyore ; Chen, Chun-liang ; Besner, Gail E. / Heparin-binding epidermal growth factor-like growth factor (HB-EGF) preserves gut barrier function by blocking neutrophil-endothelial cell adhesion after hemorrhagic shock and resuscitation in mice. In: Surgery. 2012 ; Vol. 151, No. 4. pp. 594-605.
@article{5aecd9e5b5fe4e8ba3b3f30469e70424,
title = "Heparin-binding epidermal growth factor-like growth factor (HB-EGF) preserves gut barrier function by blocking neutrophil-endothelial cell adhesion after hemorrhagic shock and resuscitation in mice",
abstract = "Background: We have shown that heparin-binding epidermal growth factor-like growth factor (HB-EGF) protects the intestines from injury in several different animal models, including hemorrhagic shock and resuscitation (HS/R). The current study was designed to explore the mechanisms underlying the anti-inflammatory role of HB-EGF in preservation of gut barrier function after injury. Methods: In vivo, HS/R was induced in wild-type and neutropenic mice, with or without administration of HB-EGF, and intestinal permeability determined by use of the everted gut sac method. In vitro, cultured human umbilical vein endothelial cells (HUVECs) and freshly isolated human peripheral blood mononuclear cells (PMNs) were used to determine the effects of HB-EGF on HUVEC-PMN adhesion, reactive oxygen species production in PMN, adhesion molecule expression in HUVEC and PMN, and the signaling pathways involved. Results: We found that administration of HB-EGF to healthy mice led to preservation of gut barrier function after HS/R. Likewise, induction of neutropenia in mice also led to preservation of gut barrier function after HS/R. Administration of HB-EGF to neutropenic mice did not lead to further improvement in gut barrier function. In vitro studies showed that HB-EGF decreased neutrophil-endothelial cell (PMN-EC) adherence by down-regulating adhesion molecule expression in EC via the phosphoinositide 3-kinase-Akt pathway, and by inhibiting adhesion molecule surface mobilization and reactive oxygen species production in PMN. Conclusion: These results indicate that HB-EGF preserves gut barrier function by inhibiting PMN and EC activation, thereby blocking PMN-EC adherence after HS/R in mice, and support the future use of HB-EGF in disease states manifested by hypoperfusion injury.",
author = "Zhang, {Hong Yi} and Iyore James and Chun-liang Chen and Besner, {Gail E.}",
doi = "10.1016/j.surg.2011.10.001",
journal = "Surgery (United States)",
publisher = "Mosby Inc.",
T1 - Heparin-binding epidermal growth factor-like growth factor (HB-EGF) preserves gut barrier function by blocking neutrophil-endothelial cell adhesion after hemorrhagic shock and resuscitation in mice
AU - Zhang, Hong Yi
AU - James, Iyore
AU - Chen, Chun-liang
AU - Besner, Gail E.
N2 - Background: We have shown that heparin-binding epidermal growth factor-like growth factor (HB-EGF) protects the intestines from injury in several different animal models, including hemorrhagic shock and resuscitation (HS/R). The current study was designed to explore the mechanisms underlying the anti-inflammatory role of HB-EGF in preservation of gut barrier function after injury. Methods: In vivo, HS/R was induced in wild-type and neutropenic mice, with or without administration of HB-EGF, and intestinal permeability determined by use of the everted gut sac method. In vitro, cultured human umbilical vein endothelial cells (HUVECs) and freshly isolated human peripheral blood mononuclear cells (PMNs) were used to determine the effects of HB-EGF on HUVEC-PMN adhesion, reactive oxygen species production in PMN, adhesion molecule expression in HUVEC and PMN, and the signaling pathways involved. Results: We found that administration of HB-EGF to healthy mice led to preservation of gut barrier function after HS/R. Likewise, induction of neutropenia in mice also led to preservation of gut barrier function after HS/R. Administration of HB-EGF to neutropenic mice did not lead to further improvement in gut barrier function. In vitro studies showed that HB-EGF decreased neutrophil-endothelial cell (PMN-EC) adherence by down-regulating adhesion molecule expression in EC via the phosphoinositide 3-kinase-Akt pathway, and by inhibiting adhesion molecule surface mobilization and reactive oxygen species production in PMN. Conclusion: These results indicate that HB-EGF preserves gut barrier function by inhibiting PMN and EC activation, thereby blocking PMN-EC adherence after HS/R in mice, and support the future use of HB-EGF in disease states manifested by hypoperfusion injury.
AB - Background: We have shown that heparin-binding epidermal growth factor-like growth factor (HB-EGF) protects the intestines from injury in several different animal models, including hemorrhagic shock and resuscitation (HS/R). The current study was designed to explore the mechanisms underlying the anti-inflammatory role of HB-EGF in preservation of gut barrier function after injury. Methods: In vivo, HS/R was induced in wild-type and neutropenic mice, with or without administration of HB-EGF, and intestinal permeability determined by use of the everted gut sac method. In vitro, cultured human umbilical vein endothelial cells (HUVECs) and freshly isolated human peripheral blood mononuclear cells (PMNs) were used to determine the effects of HB-EGF on HUVEC-PMN adhesion, reactive oxygen species production in PMN, adhesion molecule expression in HUVEC and PMN, and the signaling pathways involved. Results: We found that administration of HB-EGF to healthy mice led to preservation of gut barrier function after HS/R. Likewise, induction of neutropenia in mice also led to preservation of gut barrier function after HS/R. Administration of HB-EGF to neutropenic mice did not lead to further improvement in gut barrier function. In vitro studies showed that HB-EGF decreased neutrophil-endothelial cell (PMN-EC) adherence by down-regulating adhesion molecule expression in EC via the phosphoinositide 3-kinase-Akt pathway, and by inhibiting adhesion molecule surface mobilization and reactive oxygen species production in PMN. Conclusion: These results indicate that HB-EGF preserves gut barrier function by inhibiting PMN and EC activation, thereby blocking PMN-EC adherence after HS/R in mice, and support the future use of HB-EGF in disease states manifested by hypoperfusion injury.
U2 - 10.1016/j.surg.2011.10.001
DO - 10.1016/j.surg.2011.10.001
JO - Surgery (United States)
JF - Surgery (United States)
10.1016/j.surg.2011.10.001